Stem Cell Exhaustion

The table below contains sentences from PubMed articles, which describe the contribution of stem cell exhaustion in the development, or disordered physiology of, a disease.
The sentences are derived from predictions after applying a supervised machine learning approach.
The columns represent the matched concept from the UMLS Metathesaurus, the matched aging hallmark, the sentence and the PubMed identifier.
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Matched Disease Name	Matched Aging Hallmark	Sentence	PMID
Specialty Type - cancer	Stem Cell Exhaustion	A clinical and pharmacokinetic study of high-dose carboplatin, paclitaxel, granulocyte colony-stimulating factor, and peripheral blood stem cells in patients with unresectable or metastatic cancer.	7481867
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We suggest that blast cells from these patients may undergo differentiation similar to that of primitive stem cells that implies the existence of a new immunological variant of CML blast crisis, a primitive variant.	7482298
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	The results demonstrate that PNH involves the lymphoid as well as the myeloerythroid lineage, and therefore arises from a totipotent bone marrow stem cell.	7485098
Childhood Breast Carcinoma	Stem Cell Exhaustion	High-dose 90Y Mx-diethylenetriaminepentaacetic acid (DTPA)-BrE-3 and autologous hematopoietic stem cell support (AHSCS) for the treatment of advanced breast cancer: a phase I trial.	7493371
BCR gene	Stem Cell Exhaustion	The expression of the pluripotent stem cell antigen CD34 was evaluated at diagnosis in forty-five adult patients with de novo ALL.	7496352
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	R-verapamil caused a dose-dependent inhibition of AML blast proliferation in the presence of stem-cell factor, leukemia inhibitory factor, interleukin 4, interleukin 6, and interleukin 10 when these cytokines were tested both alone and in different combinations.	7497600
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Detection of minimal residual disease in a patient with acute myeloid leukemia and t(6;9) at the time of peripheral blood stem cell transplantation.	7502630
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 16-year-old Japanese woman with acute myelogenous leukemia (AML) and t(6;9) received peripheral blood stem cell transplantation (PBSCT).	7502630
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Combinations of stem cell factor with other hematopoietic growth factors enhance growth and sensitivity to cytosine arabinoside of blast progenitors in acute myelogenous leukemia.	7506123
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We report the effects of stem cell factor (SCF) on the growth and sensitivity to 1-beta-D-arabinofuranosylcytosine (Ara-C) of blast progenitors in acute myelogenous leukemia.	7506123
Concomitant Medication Submission Domain, Neoplasms, Myeloid Progenitor Cells	Stem Cell Exhaustion	Culture media (CM) incubated with the excised tumour tissues stimulated the colony formation of bone marrow myeloid progenitor cells in vitro.	7506922
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myelogenous leukemia (CML) is a clonal disorder of the hematopoietic stem cell characterized by the coexistence of Philadelphia-negative (Ph-) with Ph+ progenitors.	7509656
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	CML progenitor cells have been shown to be defective in adherence to marrow stroma.	7509656
Peripheral Blood Stem Cells, Malignant neoplasm of testis	Stem Cell Exhaustion	[Ultra high-dose chemotherapy with peripheral blood stem cell autotransplantation for refractory testicular cancer].	7510451
Neoplasms	Stem Cell Exhaustion	Double-cycle high-dose chemotherapy with peripheral blood stem cells and hematopoietic growth factor support in patients with advanced solid tumor.	7511042
Toxic effect	Stem Cell Exhaustion	It is important to determine whether peripheral blood stem cells and hematopoietic growth factors can diminish the hematopoietic toxicity of such a treatment.	7511042
Toxic effect	Stem Cell Exhaustion	With the use of peripheral stem cells and growth factors, high-dose chemotherapy could be given safely every 30 days with acceptable toxicity.	7511042
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	The myelodysplastic syndromes are a heterogeneous group of hematopoietic stem cell diseases in which both diagnosis and prognosis are determined by cellular morphologic criteria.	7511190
PAFAH1B1 wt Allele, DPM1 gene	Stem Cell Exhaustion	The data suggest that increased amounts of circulating stem/progenitor cells with c-kit receptor are found in MPDs and MDS.	7512174
Severe congenital neutropenia	Stem Cell Exhaustion	Increased cytokine levels and abnormal response of myeloid progenitor cells to granulocyte colony-stimulating factor in a case of severe congenital neutropenia.	7513137
Stem Cell Factor	Stem Cell Exhaustion	The CD34+ cells of both RA/RARS and RAEB/RAEB-t exhibited a similarity to the cells of normal individuals in their responsiveness to the addition of interleukin 6 (IL-6), IL-3 or stem cell factor (SCF).	7514249
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Growth analysis of marrow CD34-positive hematopoietic progenitor cells in patients with myelodysplastic syndromes.	7514249
Stem Cell Factor	Stem Cell Exhaustion	We demonstrated that MDS marrow hematopoietic progenitor cells reactive to GM-CSF or EPO were additionally stimulated with early-acting hematopoietic growth factors including IL-6, IL-3 and SCF in a fashion similar to those of normal individuals.	7514249
Lymphoma	Stem Cell Exhaustion	Sequential peripheral blood progenitor cell transplantation after mobilization with salvage chemotherapy and G-CSF in patients with resistant lymphoma.	7514355
Lymphoma, Non-Hodgkin, Familial, HD Term Type, Lymphoma	Stem Cell Exhaustion	We enrolled 18 patients affected by refractory or relapsed lymphoma (HD, NHL) in a two-step protocol that included salvage chemotherapy with mitoxantrone, carboplatinum, methylprednisolone, and cytosine arabinoside (MiCMA) plus G-CSF (5 micrograms/kg/day), peripheral blood progenitor cell (PBPC) collection, and subsequent transplantation after BUCY2 regimen.	7514355
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Evidence for nonclonal hematopoietic progenitor cell populations in bone marrow of patients with myelodysplastic syndromes.	7517721
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Clonality of marrow hematopoietic progenitor cells in myelodysplastic syndromes (MDS) was analyzed by X-chromosome inactivation pattern using polymerase chain reaction (PCR).	7517721
PAFAH1B1 wt Allele	Stem Cell Exhaustion	We conclude that nonclonal hematopoietic progenitor cells can persist in a substantial number of MDS patients.	7517721
Goiter	Stem Cell Exhaustion	In 2 goiters, the monoclonal nodules were shown to derive from different progenitor cells.	7517946
Blast Phase, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Transplantation of allogeneic peripheral blood stem cells after myeloablative treatment of a patient in blastic crisis of chronic myelocytic leukemia.	7518995
Blast Phase, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	A 48-year-old man in blastic crisis of chronic myelocytic leukemia received a transplant of allogeneic peripheral blood stem cells.	7518995
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Here, we studied the interactions between TNF alpha and the stem cell factor (SCF) receptor, c-kit, in normal CD34+ hematopoietic progenitors and their leukemic counterpart, ie, acute myeloid leukemic (AML) CD34+ cells coexpressing c-kit antigen.	7522632
Childhood Breast Carcinoma	Stem Cell Exhaustion	Release of peripheral blood progenitor cells during standard dose cyclophosphamide, epidoxorubicin, 5-fluorouracil regimen plus granulocyte colony stimulating factor for breast cancer therapy.	7522948
Neoplasms	Stem Cell Exhaustion	High dose chemotherapy with the support of peripheral blood progenitor cells (PBPC) is increasingly used in the treatment of solid tumors.	7522948
Childhood Breast Carcinoma	Stem Cell Exhaustion	Peripheral blood progenitor cells were studied by clonogenic assay of granulocyte macrophage colony-forming units (CFU-GM), megakaryocyte colony-forming unit (CFU-Meg) and erythrocyte burst-forming unit (BFU-E) and by flow cytometric analysis of CD34+ cells in 12 patients with early breast cancer throughout three cycles of CEF chemotherapy plus G-CSF.	7522948
Stem Cell Factor	Stem Cell Exhaustion	In order to understand better the meaning of such a biological heterogeneity, we examined the in vitro response of erythroid progenitors CFU-E (colony-forming unit-erythroid) and BFU-E (burst-forming unit-erythroid) to erythropoietin (Epo), interleukin-3 (IL-3) and stem cell factor (SCF) in a large series of 24 patients from 1 month to over 20 years of age.	7524624
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	The persistence of the affected T cells may be explained either by an inherently long life span after the disappearance of the PNH stem cell or by insidious production at a subclinical level by affected stem cell.	7524752
Childhood Malignant Solid Neoplasm	Stem Cell Exhaustion	Sequential changes in stem cell markers in peripheral blood and leukapheresis samples after injections of recombinant human granulocyte colony-stimulating factor in patients with urogenital malignant solid tumors: a preliminary study.	7526017
Malignant Neoplasms	Stem Cell Exhaustion	In order to evaluate the mobilization effect of recombinant human granulocyte colony-stimulating factor (rhG-CSF) on peripheral blood stem cells (PBSCs), rhG-CSF was given to patients with urogenital malignancy before chemotherapy.	7526017
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	In a search for a mechanism to explain the impaired growth of progenitor cells in patients with myelodysplastic syndromes (MDS), marrow CD34+ cells were purified up to 94.9% +/- 4.2% for normal individuals and 88.1% +/- 17.6% for MDS patients, using monoclonal antibodies and immunomagnetic microspheres (MDS CD34+ cells).	7528567
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Therefore, this study provides direct evidence for the lineage commitment of MDS CD34+ cells to nonerythroid with impaired differentiation and explains the mechanism of nil or low colony expression of MDS progenitor cells to erythroid lineage.	7528567
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	[Effect of recombinant human stem cell factor (rhSCF) on self-renewal of stem/progenitor cells of human acute myelogenous leukemia].	7528655
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Using serum-free culture system and liquid/semi-solid dual culture technique, we examined the effect of rhSCF on self-renewal of the stem/progenitor cells of human acute myelogenous leukemia (AML-CFU).	7528655
Bacterial Infections	Stem Cell Exhaustion	Cytokines and progenitor cells of granulocytopoiesis in peripheral blood of patients with bacterial infections.	7528729
Bacterial Infections	Stem Cell Exhaustion	The results indicate that the age-dependent myelopoietic response to acute bacterial infections is characterized by an inverse relationship between progenitor cells and G-CSF.	7528729
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Stem cell factor enhanced the colony growth in five out of six acute myeloblastic leukemia cases expressing the c-kit molecule.	7529077
Neoplasms	Stem Cell Exhaustion	Treatment approaches, using chemotherapeutic dose escalation and hematopoietic stem cell support have resulted in significant augmentation of tumor mass reduction such that complete remissions are effected in approximately 50% of patients.	7529259
Hematologic Neoplasms	Stem Cell Exhaustion	Peripheral blood progenitor cell transplantation in 118 patients with hematological malignancies: analysis of factors affecting the rate of engraftment.	7530133
Hematologic Neoplasms	Stem Cell Exhaustion	We retrospectively studied the factors affecting the rate of hematopoietic reconstitution (HR) in 118 patients with hematological malignancies who underwent peripheral blood progenitor cell (PBPC) transplantation at a single institution.	7530133
Myeloid Progenitor Cells	Stem Cell Exhaustion	Although in vitro marrow myeloid progenitor cell (CFU-GM) growth stimulated by G-CSF generally remained subnormal, in the majority of neutrophil responders significantly augmented incremental change (termed AIC) of CFU-GM numbers occurred after treatment, as did neutrophilic differentiation.	7531261
Small cell carcinoma of lung	Stem Cell Exhaustion	In an ongoing phase I-II trial, limited-disease small cell lung cancer patients received high-dose chemotherapy and autologous peripheral blood progenitor cell (PBPC) transplantation as part of an early intensification strategy after two cycles of induction chemotherapy.	7531368
Concomitant Medication Submission Domain	Stem Cell Exhaustion	A stem cell assay revealed that conditioned medium (CM) of MISK81-5 contained granulocyte colony-stimulating factor (G-CSF) or interleukin-6 activity.	7531680
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Sensitivities of AML blast stem cells to idarubicin and daunorubicin: a comparison with normal hematopoietic progenitors.	7533865
Acute lymphocytic leukemia	Stem Cell Exhaustion	Granulocyte-colony stimulating factor, granulocyte-macrophage colony stimulating factor, PIXY-321, stem cell factor, interleukin-3, and interleukin-7: receptor binding and effects on clonogenic proliferation in acute lymphoblastic leukemia.	7535143
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	To investigate the role of colony stimulating factors (CSFs) in the proliferation and differentiation of progenitor cells from myelodysplastic syndromes (MDS), marrow progenitor cells from 18 MDS patients were highly purified using CD34 monoclonal antibody and immunomagnetic microspheres (MDS CD34+ cells).	7535245
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Among the tested CSFs, such as rM-CSF, rG-CSF, rGM-CSF and rIL-3, a combination of the first three CSFs was the most effective stimulus for the proliferation of non-erythroid MDS progenitor cells.	7535245
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Therefore, in vivo administration of G-CSF combined with GM-CSF to MDS patients may be one of the most effective CSF combinations for proliferation of MDS progenitor cells to the non-erythroid lineage.	7535245
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	Thus, affected reticulocytes could be a reliable marker for the diagnosis of PNH and for the evaluation of erythropoiesis by PNH stem cell.	7536494
Acute Promyelocytic Leukemia, ATRICHIA WITH PAPULAR LESIONS	Stem Cell Exhaustion	The hierarchical level of stem cell involvement in acute promyelocytic leukemia (APL) characterized by the pathognomonic PML-RARA fusion gene is unknown.	7536493
Acute Promyelocytic Leukemia	Stem Cell Exhaustion	Highly purified primitive hematopoietic stem cells are PML-RARA negative and generate nonclonal progenitors in acute promyelocytic leukemia.	7536493
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Also, the present results showed that monocytic differentiation of blast cells in AMegL could be stimulated by IFN-gamma, supporting the multipotent stem or progenitor cell origin of the AMegL subtype of acute myelogenous leukaemia.	7536511
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Changes in erythroid progenitor cell and accessory cell compartments in patients with myelodysplastic syndromes during treatment with all-trans retinoic acid and haemopoietic growth factors.	7537524
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic peripheral blood progenitor cells mobilized by G-CSF (filgrastim) for a second transplant in a patient with acute myeloid leukemia in relapse.	7537999
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 25-year-old man with AML, who relapsed 21 months after his first allogeneic bone marrow transplant (BMT), underwent a second transplant with peripheral blood progenitor cells (PBPC) obtained from his HLA-identical sibling.	7537999
Anemia, Encephalitis, St. Louis, White blood cell count decreased	Stem Cell Exhaustion	Thus, IgG autoantibodies to primitive haematopoietic progenitor cells are demonstrated to be present in the sera of a significant proportion of active SLE patients with anaemia and leukocytopenia and to suppress the progenitor cell growth.	7539726
Neoplasms, Specialty Type - cancer, Hollings Cancer Center	Stem Cell Exhaustion	The conclusions are: 1) the combined type is generated from two sources; one is the intrahepatic double cancer (thoroughly separate type and a part of the collision type) and another is the stem cell origin with diverse phenotypes (intermingled type and a part of the collision tumor); and 2) AE1 was the most helpful marker to differentiate the CCC area from HCC, and other markers, e.g.	7539881
Multiple Myeloma	Stem Cell Exhaustion	Comparative study of peripheral blood progenitor cell collection in patients with multiple myeloma after single-dose cyclophosphamide combined with rhGM-CSF or rhG-CSF.	7540856
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Patients suffering from high-risk multiple myeloma (MM) were randomized to receive single high-dose cyclophosphamide followed by either rhGM-CSF or rhG-CSF in order to harvest circulating peripheral blood progenitor cells.	7540856
Toxic effect	Stem Cell Exhaustion	The safety of the procedure, the mobilization kinetics, the relative efficacy of rhGM-CSF and rhG-CSF to mobilize progenitor cells and their relative toxicity were studied.	7540856
Multiple Myeloma	Stem Cell Exhaustion	A multi-institutional study of purified CD34-selected peripheral blood progenitor cell (PBPC) transplantation was conducted in 37 patients with advanced multiple myeloma receiving myeloablative chemotherapy.	7540888
Multiple Myeloma	Stem Cell Exhaustion	Transplantation of CD34+ peripheral blood progenitor cells after high-dose chemotherapy for patients with advanced multiple myeloma.	7540888
AKAP13 wt Allele, Disease, MYELODYSPLASTIC SYNDROME, Myeloid Leukemia, Chronic, Blast Phase, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	High-density Thy-1 expression was found in 1 case of CML in lymphoid blast crisis, and low-density Thy-1 expression was identified on a portion of the leukemic cells in 2 cases of AML with myelodysplastic features, and 1 case of CML in myeloid blast crisis, suggesting a possible correlation between Thy-1 expression and certain instances of stem cell disorders such as CML and AML with dysplastic features.	7540889
leukemia, Acute leukemia	Stem Cell Exhaustion	In contrast, the dissociation of Thy-1 and CD34 expression in the majority of acute leukemias studied suggests that the development of these leukemias occurs at a later stage than the hematopoietic stem cell.	7540889
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Furthermore, rhTPO-induced proliferation of AML cells was augmented with the addition of interleukin-3 (IL-3), IL-6, stem cell factor, or granulocyte-macrophage colony-stimulating factor.	7541672
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Cytogenetically aberrant cells in the stem cell compartment (CD34+lin-) in acute myeloid leukemia.	7542497
PAFAH1B1 wt Allele, leukemia, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We investigated stem cell involvement in leukemia using fluorescence in situ hybridization (FISH), immunofluorescence labeling of hematopoietic subpopulations, and flow cytometric analysis/sorting to discriminate and quantify cytogenetically aberrant stem cells in 12 acute myeloid leukemia (AML) and three myelodysplastic (MDS) specimens.	7542497
leukemia	Stem Cell Exhaustion	Leukemia may be viewed as a clonal expansion of blast cells; however, the role of primitive cells and/or stem cells in disease etiology and progression is unclear.	7542497
Neoplasms	Stem Cell Exhaustion	Possible mechanisms include abnormal or deregulated gene expression, autocrine or paracrine effects or a stem cell origin of tumour.	7542980
Stem Cell Factor	Stem Cell Exhaustion	The combination of bFGF or a FGF and G-CSF, GM-CSF, interleukin-3, or stem cell factor (SCF) had a synergistic effect on blast-colony formation in three patients.	7543415
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Trisomy 4 in 'stem cell-like' leukemic cells of a patient with AML.	7543964
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The experiments point to the existence of leukemic stem cells in the CD34+/CD38- compartment in AML patients with trisomy 4.	7543964
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	CD34 positive progenitor cells were analyzed in the bone marrow aspirate from a patient with newly diagnosed AML FAB M4.	7543964
Adult chronic idiopathic neutropenia	Stem Cell Exhaustion	Distinct effect of G-CSF on the growth and differentiation of myeloid progenitor cells from chronic idiopathic neutropenia.	7544173
Cervical Intraepithelial Neoplasia	Stem Cell Exhaustion	We examined the effect of recombinant human granulocyte-colony stimulating factor (rhG-CSF) on the growth and maturation of the myeloid progenitor cells from a patient with CIN.	7544173
RPS19 gene, Stem Cell Factor	Stem Cell Exhaustion	To characterize the production of stem cell factor (SCF, the ligand for the c-kit receptor protein) and its regulation by inflammatory cytokines and glucocorticoids, primary marrow stromal fibroblasts were isolated from normal individuals and two patients with Diamond-Blackfan anemia.	7544739
PAFAH1B1 wt Allele, Stem Cell Factor, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Responsiveness to stem cell factor (SCF) of peripheral blood colony-forming cells from patients with myelodysplastic syndromes (MDS).	7544850
Graft-vs-Host Disease	Stem Cell Exhaustion	Allogeneic blood stem cell transplantation: peripheralization and yield of donor-derived primitive hematopoietic progenitor cells (CD34+ Thy-1dim) and lymphoid subsets, and possible predictors of engraftment and graft-versus-host disease.	7545476
Mastocytosis	Stem Cell Exhaustion	Expression of stem cell factor in cutaneous mastocytosis.	7547385
Skin lesion, Mastocytosis, Urticaria Pigmentosa	Stem Cell Exhaustion	In order to evaluate its possible role in human mastocytosis, skin lesions from 13 patients with urticaria pigmentosa and five patients with mastocytomas, and normal skin specimens from five healthy donors were studied by immunohistochemistry, using polyclonal and monoclonal (hkl-12) antibodies against stem cell factor, and a monoclonal antibody (YB5.B8) against its receptor, the c-kit proto-oncogene product.	7547385
Urticaria Pigmentosa, Benign Mastocytoma	Stem Cell Exhaustion	Mastocytomas and urticaria pigmentosa lesions thus exhibit different patterns of stem cell factor expression.	7547385
Palmar-plantar erythrodysesthesia syndrome	Stem Cell Exhaustion	Stem cell factor showed only weak growth-stimulatory effect on MHH225 cells but significantly inhibited chemotherapy-induced apoptosis in these cells.	7548328
Polycythemia Vera	Stem Cell Exhaustion	Circulating hematopoietic progenitor cells in polycythemia vera: the in vivo effect of hydroxyurea.	7548329
Therapy-Related Leukemia, Multiple Myeloma	Stem Cell Exhaustion	These findings indicate that the AMMoL was a therapy-related stem cell leukemia and was a clonal origin genetically different from multiple myeloma irrespective of plasma cell phenotype.	7549140
Sarcoma - category (morphologic abnormality)	Stem Cell Exhaustion	We considered that sarcoma cells might originate in SCC, representing its metaplastic differentiation, or that both SCC and sarcoma might originate in a pluripotent stem cell.	7551000
Neoplasms	Stem Cell Exhaustion	The former tumour was considered to be of T-cell lineage and the latter of lymphoid progenitor cell origin.	7551339
Bacterial Infections, Stem Cell Factor	Stem Cell Exhaustion	The present study is to evaluate, in addition to TNF-alpha and G-CSF, whether serum stem cell factor (SCF), interleukin-3 (IL-3) and granulocyte-macrophage-CSF (GM-CSF) levels to see if they were also elevated in patients with acute bacterial infection.	7553424
Multiple Myeloma	Stem Cell Exhaustion	[Peripheral blood stem cell transplantation for rapidly spreading myeloma].	7563608
Peripheral Stem Cell Transplantation, Multiple Myeloma	Stem Cell Exhaustion	We report a case of rapidly spreading myeloma of immature cell morphology treated by peripheral blood stem cell transplantation (PBSCT).	7563608
Myeloid	Stem Cell Exhaustion	The seeming paradox of detectability of mtDNA-4977 in hematologically normal individuals and its absence in clonal myeloid disorders is explained by varying selection against self-renewing stem cells harboring the common deletion.	7564514
Abnormality of mitochondrial metabolism	Stem Cell Exhaustion	Selection appears to be effective under circumstances of proliferative stress (eg among continuously proliferating stem cells in clonal hematopoiesis), whereas in normal steady-state hematopoiesis, affected stem cells persist because they are rarely recruited into cell cycle and can thus tolerate mitochondrial dysfunction.	7564514
Intravascular hemolysis, Venous Thrombosis, Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH), which is characterized by intravascular hemolysis and venous thrombosis, is an acquired clonal disorder associated with a somatic mutation in a totipotent hematopoietic stem cell.	7566002
Barretts Adenocarcinoma", Metaplasia	Stem Cell Exhaustion	This pancreatic parenchyma in Barrett's mucosa is most likely of metaplastic origin and could be derived from the transitional zone cells or from pluripotent stem cells in the esophageal mucosa or from metaplasia of mucus cells.	7573675
Respiration Disorders	Stem Cell Exhaustion	Regulation of histamine release from human bronchoalveolar lavage mast cells by stem cell factor in several respiratory diseases.	7573818
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We conclude that clonal karyotypic abnormalities are frequently found in the stem cell-like (CD34+/CD38-) and more mature (CD34+/CD38+) populations of patients with AML, irrespective of the phenotype of the bulk population of leukemic blasts and of the primary or secondary character of the leukemia.	7579382
S100A4 protein, human, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Evidence for malignant transformation in acute myeloid leukemia at the level of early hematopoietic stem cells by cytogenetic analysis of CD34+ subpopulations.	7579382
Anti-Dopamine-b-Hydroxylase Monoclonal Antibody-Saporin	Stem Cell Exhaustion	We report a 62-year-old man who developed DSAP in a widely and rapidly progressive manner within days of receiving total body radiation and high-dose induction chemotherapy as planned preparative therapy for an autologous peripheral blood stem cell transplant for relapsed high grade lymphoma.	7581104
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Peripheral blood stem cell collection in a patient with chronic myelogenous leukemia and a high circulating nucleated red cell fraction.	7592523
Peripheral Blood Stem Cells, Chronic myeloproliferative disorder	Stem Cell Exhaustion	A high level of circulating nucleated red blood cells (NRBC) in patients with chronic myeloproliferative syndromes could potentially complicate peripheral blood stem cell (PSC) collection.	7592523
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In acute non-lymphoblastic leukemia (ANLL) progenitor cells frequently display a certain degree of autonomous growth.	7596154
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	This case adds to the growing evidence that CML may be a disorder of the common stem cell from which T-, B- and myeloid progenitors originate.	7597876
Malignant Neoplasms	Stem Cell Exhaustion	Erythropoietin for mobilization of circulating progenitor cells in patients with previously treated relapsed malignancies.	7601251
Toxic effect, Chemosensitivity, Metastatic Neoplasm, Secondary malignant neoplasm of viscera	Stem Cell Exhaustion	High dose chemotherapy followed by autologous stem cell rescue (bone marrow or peripheral blood) is associated with significant response and possibly improved survival in chemosensitive patients with metastatic disease without visceral metastases though with significant toxicities and cost (median survival rate of 20 months).	7605906
Anemia, Malaria, Falciparum	Stem Cell Exhaustion	Recent studies demonstrated that MIP-1 alpha may also act as potent inhibitor of hemopoetic stem cell proliferation, which may be important in the development of prolonged anemia in patients suffering from Plasmodium falciparum malaria.	7606866
Mantle cell lymphoma	Stem Cell Exhaustion	The role of high-dose therapy and autologous hematopoietic stem cell transplantation for mantle cell lymphoma.	7612492
Medial collateral ligament	Stem Cell Exhaustion	This paper will evaluate patients with MCL receiving either induction therapy with an anthracycline or high-dose chemotherapy and autologous hematopoietic stem cell transplantation for relapsed disease.	7612492
Medial collateral ligament	Stem Cell Exhaustion	During the same time period, a different set of nine patients with recurrent MCL were referred for high-dose chemoradiotherapy and autologous stem cell rescue as salvage therapy.	7612492
Toxic effect	Stem Cell Exhaustion	This enhancement of toxicity is generally thought to reflect depletion of stem cells within the tissue concerned.	7619762
Invasive carcinoma of breast	Stem Cell Exhaustion	In the first case, a 43-year-old woman with Stage IV infiltrating ductal breast cancer presented to the hospital for a transplant of autologous peripheral blood stem cells.	7631411
Childhood Breast Carcinoma	Stem Cell Exhaustion	Prognostic factors for prolonged progression-free survival with high-dose chemotherapy with autologous stem-cell support for advanced breast cancer.	7636547
Toxic effect	Stem Cell Exhaustion	The present study reveals an inhibitory action of plasma on the toxicity of mafosfamide to normal haematopoietic progenitor cells.	7644349
HIV-Associated Lymphoproliferative Disorder	Stem Cell Exhaustion	It is concluded that EBV-associated lymphoproliferative disorders may be a complication, albeit a rare one, of intensive therapy with autologous stem cell support.	7655394
MCV - raised, PAFAH1B1 wt Allele	Stem Cell Exhaustion	Eight of our nine macrocytic patients who did not fulfill the FAB criteria for MDS had at least one of the alterations studied; this suggests that these patients might represent early phases of a stem cell disorder.	7669657
N-ras Genes	Stem Cell Exhaustion	The analyses used were: DNA-methylation at the calcitonin A gene 5'-area, NRAS point mutations at codons 12 and 13, in vitro colony formation of peripheral blood progenitor cells and cytogenetics of bone marrow cells.	7669657
Eosinophil count raised (finding)	Stem Cell Exhaustion	Early GM-CSF administration markedly increased the leucocyte nadir and produced two waves of leucocytosis: an early one, linked to marrow reserve release and presumably of no value to the patients; and a delayed one, due to marrow precursor and progenitor cell proliferation, in which the granulomonocytosis was associated with a marked eosinophilia.	7695978
Malignant Neoplasms	Stem Cell Exhaustion	A considerable number of patients with malignancies who are treated with high-dose therapy and hematopoietic stem cell transplantation subsequently relapse.	7703499
Specialty Type - cancer	Stem Cell Exhaustion	Analyses of peripheral blood stem cell (PBSC) harvests obtained from 49 cancer patients showed that the PBSC harvest contained precursors for antitumor effector cells.	7703499
Specialty Type - cancer	Stem Cell Exhaustion	We report the results of a functional and phenotypical characterization of PBSC obtained from six consecutive collections from 18 cancer patients receiving granulocyte-macrophage colony-stimulating factor (GM-CSF) for hematopoietic stem/progenitor cell mobilization.	7703499
Failure, B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1	Stem Cell Exhaustion	Allogeneic peripheral blood stem cell transplantation for treatment of induction failure in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia.	7718769
Acute lymphocytic leukemia, Primary Induction Failure, BCR gene	Stem Cell Exhaustion	We report a successful case of allogeneic peripheral blood stem cell transplantation (PBSCT) for the treatment of primary induction failure in acute lymphoblastic leukemia (ALL).	7718769
renal anemia	Stem Cell Exhaustion	Effects of monocyte-macrophage colony-stimulating factor (M-CSF) on in vitro erythropoiesis of marrow progenitor cells from patients with renal anemia.	7720833
renal anemia	Stem Cell Exhaustion	Together, these results suggest that M-CSF aggravates a previously existing decreased sensitivity of erythroid progenitor cells to Epo in some patients with renal anemia.	7720833
MLH1 protein, human, Crohn Disease, Brain Damage, Chronic	Stem Cell Exhaustion	In HNPCC patients aged < 49 years the mean stem cell mutation frequency was significantly lower than in the slightly younger group of patients with Crohn's disease (0.8 +/- 0.9 x 10(-4) vs 3.5 +/- 3.3 x 10(-4), P < 0.01), probably reflecting an increased mutation rate relating to chronic mucosal damage in Crohn's disease.	7734304
MLH1 protein, human, Cytogenetic Complete Response	Stem Cell Exhaustion	Although not statistically significant, the stem cell mutation frequency was slightly less in HNPCC patients > 50 years than in sporadic CRC cases (4.9 +/- 3.4 x 10(-4) vs 5.9 +/- 3.6 x 10(-4), P > 0.5).	7734304
Pterygium	Stem Cell Exhaustion	In recent years, it has been postulated that pterygium is due to hypofunction of limbal stem cells.	7747583
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	In this Phase II trial 14 patients with advanced myelodysplastic syndrome were treated with PTX (2,000 mg/day) and Cipro (1,000 mg/day) in order to determine tolerability and effect on peripheral blood cell counts, progenitor cell responsiveness to cytokines and circulating serum levels of interleukin-6 (IL6) and TNF.	7747704
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation after first remission induction treatment in multiple myeloma: a report of the French Registry on autologous transplantation in multiple myeloma.	7756641
Multiple Myeloma	Stem Cell Exhaustion	Eighteen French centers reported 133 autologous stem cell transplantations performed after first remission induction in multiple myeloma.	7756641
Specialty Type - cancer	Stem Cell Exhaustion	In 14 previously treated cancer patients, an average of 28.9 +/- 4.9 L of blood was processed per LVL (n = 35) to collect medians of 2.5 x 10(8) mononuclear cells per kg (range, 1.0-7.4), 14 x 10(4) CFU-GM per kg (0-208), 27 x 10(4) clonogenic progenitor cells per kg (0-370), and 2.8 x 10(6) CD34+ cells per kg (0-112.5).	7770900
Anemia, Megakaryocytopoiesis	Stem Cell Exhaustion	Since an excess of myeloblasts or an increase of CD34 positive progenitor cells was not seen, the disorders were designated as 'refractory anaemia' or with regard to the dysplastic megakaryopoiesis 'MDS, unclassifiable'.	7772518
Leukemia, Myelocytic, Acute, Acute Undifferentiated Leukemia	Stem Cell Exhaustion	Ecotropic virus integration site-1 gene preferentially expressed in post-myelodysplasia acute myeloid leukemia: possible association with GATA-1, GATA-2, and stem cell leukemia gene expression.	7780155
Acute Undifferentiated Leukemia	Stem Cell Exhaustion	EVI1 expression was accompanied by expression of GATA-1 and GATA-2, and often by stem cell leukemia (SCL) gene expression.	7780155
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Increased peripheral blood normal myeloid progenitor cells (CFU-GM) in chronic lymphocytic leukemia: a perspective for autologous peripheral blood stem cell transplantation.	7789468
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	In conclusion, our data indicate that intensification with peripheral blood stem cell support may be feasible in CLL, since progenitor cells of myeloid-monocytic series are markedly increased in the peripheral blood of these patients.	7789468
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	We assayed granulocyte-macrophage committed progenitor cells (CFU-GM) in the peripheral blood of 34 patients with chronic lymphocytic leukemia (CLL) and 12 normal individuals.	7789468
leukemia	Stem Cell Exhaustion	These findings suggest that trisomy 11 leukaemia is characterized by a stem/progenitor cell immunophenotype with poor response to standard chemotherapeutic regimens and an unfavourable prognosis.	7794746
Collagen Diseases, Hematological Disease	Stem Cell Exhaustion	There is an association between hematologic disorders caused by proliferation of bone marrow derived pluripotent stem cells and rheumatic disorders.	7799343
Multiple Myeloma	Stem Cell Exhaustion	These preclinical data provide evidence that retroviral-mediated gene transfer into human myeloma cells is feasible, and form part of the basis for current clinical studies of gene marking of bone marrow or peripheral blood progenitor cells before autologous stem cell transplantation in multiple myeloma.	7803277
Damage, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Previous work has shown that hydrocortisone (HC) protects AML blast stem cells from the lethal effects of cytosine arabinoside (ara-C) while retinoic acid (ATRA) increases ara-C sensitivity; further mechanisms of regulation of ara-C sensitivity might include increase or decrease in repair of sublethal damage.	7807996
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	High-dose chemotherapy, with or without radiotherapy, followed by autologous stem-cell rescue is used increasingly for the intensification of first remission in acute myeloblastic leukemia (AML).	7812012
PAFAH1B1 wt Allele	Stem Cell Exhaustion	We suggest that our patient with the MDS has a stem cell disorder affecting all myeloid cell lineages and that basophilia constitutes a part of the malignant process.	7813709
Hematologic Neoplasms, Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	We investigated the serum cytokine levels (G-CSF, GM-CSF, IL-1 beta, IL-3 and IL-6) using an ELISA in 14 patients with haematological malignancies undergoing peripheral blood progenitor cell transplantation (PBPCT).	7819082
Toxic effect	Stem Cell Exhaustion	Maximum-tolerated doses of ifosfamide, carboplatin, and etoposide given over 6 days followed by autologous stem-cell rescue: toxicity profile.	7844593
PAFAH1B1 wt Allele, Myeloid Cell Differentiation	Stem Cell Exhaustion	The clonal nature of MDS has been demonstrated by various techniques: the stem cell involved initially is capable of myeloid and lymphoid differentiation.	7845004
Intestinal Cancer	Stem Cell Exhaustion	Stem cell kinetics and intestinal cancer.	7847853
Carcinoma, Small Cell	Stem Cell Exhaustion	All of these small-cell carcinomas are presumed to arise from a hypothetical ductal stem cell that can undergo neuroendocrine, squamous, or glandular differentiation.	7848068
Carcinoma, Small Cell	Stem Cell Exhaustion	These neuroendocrine-type small-cell carcinomas were felt to arise from neuroendocrine stem cells that migrated to the salivary gland from the neural crest.	7848068
Multiple Myeloma	Stem Cell Exhaustion	The quick reduction of differentiated myeloma cells by VAD chemotherapy (vincristine, adriamycin, dexamethasone) causes, according to the investigation by Bell et al., the acceleration of the proliferation of myeloma stem cells.	7871966
Specialty Type - cancer	Stem Cell Exhaustion	These data suggest that IL-6 alone will not be clinically useful to mobilize blood progenitor cells in cancer patients.	7873372
Lymphoma	Stem Cell Exhaustion	In the present paper, we report two cases of normal pregnancy after high dose chemotherapy and autologous stem cell transplantation (ASCT) in two of the 72 women belonging to a group of 188 patients transplanted in our unit for advanced malignant lymphoma.	7892134
Guillain-Barre Syndrome, Childhood Breast Carcinoma	Stem Cell Exhaustion	We report the case of a 44-year-old female with stage IV breast cancer who developed GBS 2 days after receiving high dose chemotherapy with bone marrow and peripheral progenitor cell support, and granulocyte-macrophage colony stimulating factor (GM-CSF).	7900710
Multiple Myeloma	Stem Cell Exhaustion	Current myeloablative treatments supported by autologous BM or blood stem cells were useful to very few patients with multiple myeloma after the first year of chemotherapy.	7904486
Multiple Myeloma	Stem Cell Exhaustion	The utility of myeloablative therapy supported by autologous bone marrow (BM) or blood progenitor cells was assessed in 49 patients with multiple myeloma who had received at least 1 year of prior chemotherapy.	7904486
LINC01152 gene	Stem Cell Exhaustion	Our findings suggest that the majority of the CMPD in these patients originated from a relatively committed progenitor cell without the capacity to differentiate into T cells, and convincingly demonstrated heterogeneity of lineage involvement.	7911034
Hematologic Neoplasms	Stem Cell Exhaustion	Transplant of stem cells derived from a patient's own marrow or peripheral blood (autologous transplant) avoids the need for an HLA-matched donor, is associated with a less complicated and shorter hospital course than donor transplantation, and has been successful in the treatment of other haematological malignancies.	7911185
SLC16A1 wt Allele, Follicular thyroid carcinoma	Stem Cell Exhaustion	The morphologic findings suggest that a small number of MCTs arise from a common stem cell (possibly the ultimobranchial body) that may give rise to both MCT and follicular carcinoma.	7913660
Mastocytosis	Stem Cell Exhaustion	During a median follow-up period of 5.5 years, 10 patients with mastocytosis were re-examined with regard to clinical symptoms, urine histamine metabolites (U-MeImAA), bone marrow cells examined with chromosome analyses, and in vitro stem cell growth for CFU-GM.	7915453
Hodgkin Disease, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Forty patients with Hodgkin's disease (n = 9) and non-Hodgkin's lymphoma (n = 31) transplanted with unmobilized autologous peripheral blood stem cells or bone marrow stem cells received daily 6-hour infusions of IL-1 alpha (day 0 to day +13) at daily doses between 0.1 to 10 micrograms/m2/d; 7 patients received only 7 planned days of IL-1 alpha (day 0 through 6).	7915916
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Phase I trial of dacarbazine with cyclophosphamide, carmustine, etoposide, and autologous stem-cell transplantation in patients with lymphoma and multiple myeloma.	7916039
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	We investigated the feasibility of escalating doses of dacarbazine (DTIC) in combination with high-dose cyclophosphamide, carmustine, and etoposide (CBV) given with autologous stem-cell transplantation in 33 patients with relapsed or refractory lymphoma or multiple myeloma.	7916039
Central neuroblastoma, Malignant Childhood Neoplasm	Stem Cell Exhaustion	Neuroblastoma is an uncommon malignant neoplasm that derives from neural crest progenitor cells that normally give rise to the sympathetic nervous system.	7937266
Tay-Sachs Disease	Stem Cell Exhaustion	Through the targeted disruption of the mouse Hexa gene in embryonic stem cells, we have produced mice with biochemical and neuropathologic features of Tay-Sachs disease.	7937929
Pancreatic Ductal Adenocarcinoma	Stem Cell Exhaustion	[DNA ploidy of stem cells and prognosis of ductal adenocarcinoma of the pancreas].	7947631
Neoplasms	Stem Cell Exhaustion	The close relationship between functionally imperfect thyroid tissue and a neuroendocrine marker-secreting tumour seems to be concordant with the theory of the existence of a pluripotential stem cell capable of differentiating multidirectionally.	7957326
Tumor necrosis	Stem Cell Exhaustion	Supplementation of serum-free medium with recombinant cytokines, including stem cell factor, granulocyte-macrophage colony-stimulating factor (GM-CSF), and tumor necrosis factor (TNF)-alpha or with human placenta-conditioned medium (HPCM) matched the degree of inhibition of apoptosis induced by BMF in only 50% of cases.	7957711
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	To evaluate the radiosensitivity of self-renewing progenitor cells in acute myeloblastic leukemia (AML), we have compared the radiosensitivity of the cells grown either in methylcellulose alone for 7 days, or first in suspension culture for 7 days before being plated in methylcellulose.	7961022
MYELODYSPLASTIC SYNDROME, Cytopenia	Stem Cell Exhaustion	Myelodysplastic syndromes are a group of clonal hematopoietic stem cell disorders leading to peripheral cytopenias and a high probability of leukemic transformation.	7966085
Neoplasms	Stem Cell Exhaustion	It is thought that the Leydig elements in these tumors represent a reactive change rather than biphasic differentiation of a single stem cell capable of germinal and sex-cord cell development.	7967505
Cessation of life, Toxic effect, Comorbidity, Esophageal Neoplasms	Stem Cell Exhaustion	Conceivably, some further improvement in the results might occur from cytokines, stem cells, and brachytherapy (by decreasing deaths due to toxicity), but with so many causes of comorbidity it seems unlikely, for the foreseeable future, that the 5-year survival rate could be much improved by better treatment of esophageal cancer.	7977965
Thyroid Neoplasm	Stem Cell Exhaustion	Dual differentiation in thyroid neoplasms has been interpreted as indicative of a common stem cell origin.	7979902
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Restoration of normal polyclonal haemopoiesis in patients with chronic myeloid leukaemia autografted with Ph-negative peripheral stem cells.	7986732
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	In Genoa a programme has been initiated in which CML patients are autografted with Ph-negative peripheral stem cells.	7986732
Lymphoma, Non-Hodgkin, PAFAH1B1 wt Allele	Stem Cell Exhaustion	MDS is a potential complication of autologous bone marrow transplantation for non-Hodgkin's lymphoma; bone marrow stem-cell damage sustained before the transplant may be the most important risk factor.	7989927
Heart Block, Sinus bradycardia	Stem Cell Exhaustion	The onset of sinus bradycardia occurred at 15-513 (median 56) min and the onset of heart block ranged from 30 to 680 (median 234) min after starting the stem cell infusion.	7994256
Cardiac Arrhythmia	Stem Cell Exhaustion	Cardiac arrhythmia after infusion of cryopreserved stem cells.	7994256
Cardiac Arrhythmia	Stem Cell Exhaustion	Since some of these arrhythmias could be quite severe as assessed electrophysiologically, continuous cardiac monitoring should be considered during and after the infusion of cryopreserved stem cells.	7994256
Rhabdomyolysis	Stem Cell Exhaustion	Severe rhabdomyolysis as a complication of peripheral blood stem cell transplantation.	7994278
Ki-1+ Anaplastic Large Cell Lymphoma, Rhabdomyolysis	Stem Cell Exhaustion	We present a case of severe rhabdomyolysis developing after peripheral blood stem cell transplantation (PBSCT) in a 17-year-old woman with Ki-1 lymphoma.	7994278
Specialty Type - cancer	Stem Cell Exhaustion	Remarkably, the rate of stable aberrations, which reflects nonlethal damage in surviving stem cells, was only slightly higher among the cancer patients.	8016306
leukemia	Stem Cell Exhaustion	Assuming that the fraction of cytogenetically aberrant stem cells that survive radiotherapy contributes to the leukemogenic process, these data are then consistent with the epidemiological observations of comparable overall leukemia risks seen in these two irradiated populations.	8016306
Sellar ependymoma, interstitial	Stem Cell Exhaustion	A 62-year-old male patient with a cerebellar ependymoma showed a hypodiploid stem-cell line with clonal structural aberrations of both the long and short arms of chromosome 1, an interstitial deletion of 2q, trisomy 7, and monosomy for chromosomes 11, 13, and 16.	8019957
Polycythemia Vera, BCR gene	Stem Cell Exhaustion	The rare occurrence of ALL in polycythaemia rubra vera may indicate that in a minority of patients clonal expansion of an abnormal pluripotent haemopoietic stem cell is responsible for the polycythaemia rubra vera disease phenotype.	8027406
Leukemia, Myelocytic, Acute, Acute Undifferentiated Leukemia	Stem Cell Exhaustion	GATA-1, GATA-2, and stem cell leukemia gene expression in acute myeloid leukemia.	8035609
Leukemia, Myelocytic, Acute, Acute Undifferentiated Leukemia	Stem Cell Exhaustion	We have studied GATA-1, GATA-2, and stem cell leukemia (SCL) gene expression in 30 patients with acute myeloid leukemia (AML) by the reverse transcription-polymerase chain reaction assay.	8035609
Limbal stem cell deficiency, Aplastic Anemia	Stem Cell Exhaustion	Hence 69 cases of aplastic anemia were divided into three types: 10 cases of stem cell deficiency type, 30 cases of immuno-mediated type and 29 cases of androgen response type.	8043994
Aplastic Anemia	Stem Cell Exhaustion	Hemopoietic progenitor cells (BFU-E, CFU-E and CFU-GM) of 69 cases of aplastic anemia were cultured in vitro while the sensitivity of CFU-E and BFU-E to androgen was assayed.	8043994
Duodenal Adenoma, Adenomatous Polyposis Coli	Stem Cell Exhaustion	These results suggest that periampullary and duodenal adenomas in familial adenomatous polyposis arise from the neoplastic transformation of an undifferentiated stem cell that retains its ability for multidirectional differentiation.	8058711
Myeloid Stem Cell	Stem Cell Exhaustion	Bone marrow cellularity in myeloid stem cell disorders: impact of age correction.	8065157
PAFAH1B1 wt Allele, Myeloid Stem Cell, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The optimal cut-off value for definition of hypocellular AML and hypocellular MDS, and differences between MDS and other myeloid stem cell disorders in terms of BM cellularity have been discussed.	8065157
N-amyl-N-methylnitrosamine, Primary Myelofibrosis, Malignant Neoplasms	Stem Cell Exhaustion	Agnogenic myeloid metaplasia (AMN) with myelofibrosis is a clonal malignancy of the hematopoietic stem cell.	8141122
Myeloid Leukemia, Leukemia, Myelocytic, Acute, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	M195 is a murine monoclonal antibody that reacts with CD33, a 67-kD glycoprotein expressed on early myeloid progenitor cells and myeloid leukemia (acute myelogenous leukemia and chronic myelogenous leukemia) cells, but not normal stem cells.	8142644
Agenesis	Stem Cell Exhaustion	Failure of in vitro growth of haemopoietic progenitor cells in clonogenic assays confirmed the diagnosis of aplasia, and also confirmed that aplasia induced by this agent is not due to the presence of any humoral inhibitory factor, but to an intrinsic abnormality in the pluripotent stem cells.	8156314
Pituitary Neoplasms, Neoplasms	Stem Cell Exhaustion	The majority of human pituitary tumors have been shown to be monoclonal neoplasms, suggesting that 1 or more somatic mutations are involved in the clonal expansion of a single progenitor cell.	8157722
Neoplastic disease, Multiple Myeloma	Stem Cell Exhaustion	Multiple myeloma is a neoplastic disorder caused by the proliferation of a transformed B lymphoid progenitor cell that gives rise to a clone of immunoglobulin-secreting cells.	8163701
Stem Cell Factor	Stem Cell Exhaustion	In methylcellulose semisolid medium, the colony size and number of JKB-1 cells were increased by stem cell factor (SCF), or interleukin (IL)-3, or IL-7, but they were decreased by IL-6.	8172177
Device Cord	Stem Cell Exhaustion	The red cell-depleted fraction was shown to be enriched in progenitor cells and in cells secreting hematopoietic cytokines interleukin 3, granulocyte/macrophage colony-stimulating factor, and interleukin 6; a major source for cytokines was from cord T cells.	8183934
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A patient with acute myeloid leukaemia (AML) with an activating N-RAS oncogene mutation was studied in a haemopoietic clonogenic progenitor cell assay.	8199018
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Persistence of an activating N-RAS oncogene mutation in clonogenic progenitor cells from an acute myeloid leukaemia patient in remission.	8199018
Polycythemia Vera	Stem Cell Exhaustion	Polycythaemia vera is a clonal disorder of the haemopoietic stem cell causing a pathologic expansion of the erythroid and sometimes the megakaryocytic and myeloid elements.	8199036
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Thus cryopreservation does not appear to influence the activity of AML progenitor cells.	8199561
Childhood Breast Carcinoma, S100A4 protein, human	Stem Cell Exhaustion	A plausible biologic interpretation is that pregnancy increases the short-term risk of breast cancer by stimulating the growth of cells that have undergone the early stages of malignant transformation but that it confers long-term protection by inducing the differentiation of normal mammary stem cells that have the potential for neoplastic change.	8202106
Lymphoma, Non-Hodgkin, Familial, HD Term Type	Stem Cell Exhaustion	These results suggest that in this subset of four cases, both the NHL and HD components may have arisen from the same EBV-infected progenitor cell.	8279628
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Since the molecular defect in CML is thought to involve a pluripotent stem cell, the different effects of P210BCR-ABL and P190BCR-ABL in CML must reflect the somewhat wider spectrum of activity of the P190BCR-ABL.	8289491
Duodenal Cancer	Stem Cell Exhaustion	This case of tripartite duodenal carcinoma supports the theory of an origin from an intestinal pluripotential stem cell capable of differentiating into multiple cell types.	8293387
Neoplasms	Stem Cell Exhaustion	These findings suggest that the leiomyomatous tumor components arise from multipotent undifferentiated mesenchymal stem cells.	8307509
Osteosarcoma, Malignant Fibrous Histiocytoma, Sarcoma, Adult Leiomyosarcoma, Undifferentiated (Embryonal) Sarcoma	Stem Cell Exhaustion	The transformation to osteosarcoma and differentiated leiomyosarcoma demonstrates the potential for phenotypic changes in soft-tissue sarcomas and suggests that the malignant fibrous histiocytoma phenotype and more-differentiated sarcomas such as extraosseous osteosarcoma or leiomyosarcoma are related in a common pathway in differentiation from a primitive mesenchymal stem cell.	8311656
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation after first remission induction treatment in multiple myeloma.	8520502
Multiple Myeloma	Stem Cell Exhaustion	Eighteen French centers reported 133 autologous stem cell transplantations performed after first remission induction in multiple myeloma.	8520502
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation in multiple myeloma: results of the European Group for Bone Marrow Transplantation.	8520503
Multiple Myeloma	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation was used for treatment of 384 patients with multiple myeloma in 37 centers during the years 1986-1994.	8520503
Multiple Myeloma	Stem Cell Exhaustion	Mobilization of peripheral blood stem cells with chemotherapy and cytokines in multiple myeloma.	8520504
Multiple Myeloma	Stem Cell Exhaustion	High-dose therapy and autologous blood stem cell transplantation in multiple myeloma: preliminary results of a randomized trial involving 167 patients.	8520505
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Since 1986, we have treated young patients with aggressive multiple myeloma (MM) by high-dose chemotherapy (HDC) and total body irradiation (TBI) followed with autologous blood stem cell transplantation (ABSCT).	8520505
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The aim of the study was to evaluate the feasibility and the efficacy of high-dose chemoradiotherapy followed by autologous hematopoietic stem cell support with peripheral blood progenitor cells (PBPC) harvested after high-dose cyclophosphamide (HDCYC) treatment in patients with high-risk multiple myeloma (MM).	8520506
Multiple Myeloma	Stem Cell Exhaustion	Autologous blood progenitor cell transplantation in high-risk multiple myeloma.	8520506
melphalan/prednisone protocol	Stem Cell Exhaustion	These observations suggest that MP metabolites do not enter red cells at the stem cell level at the start of therapy.	8527282
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 31-year-old woman diagnosed with acute myelocytic leukemia received an allogeneic peripheral blood progenitor cell (PBPC) transplant one month after a previous bone marrow graft failed.	8527961
Acute leukemia	Stem Cell Exhaustion	The SR-1 monoclonal antibody (MoAb) recognizes an epitope of the c-kit receptor (KR), present on normal hemopoietic CD34+ stem cells as well as on blasts from patients with acute leukemia.	8528052
Malignant Neoplasms	Stem Cell Exhaustion	Our data suggest that two B-cell malignancies may have arisen from a single B-cell progenitor.	8531328
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	[Early relapse after peripheral blood stem cell transplantation in acute myelogenous leukemia with t(8;21)].	8531332
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We report a 3-year-old boy with acute myelogenous leukemia, who relapsed very early after peripheral blood stem cell transplantation (PBSCT).	8531332
Myeloid	Stem Cell Exhaustion	These megakaryocyte-like giant cells were positive for myeloperoxidase and CD34, but not GPIIIa and factor VIII, indicating that those were derived from myelogenous stem cells.	8531394
Adenoma, FAP protein, human, Hyperplasia	Stem Cell Exhaustion	This specialized cell hyperplasia occurred in the flat mucosa of FAP patients regardless of the presence or absence of adenomas and may represent a primary defect in the regulation of stem cell differentiation in the duodenum in FAP.	8532699
infectious - Entity Risk, Chemical injury	Stem Cell Exhaustion	In addition, the frequent coexistence of infectious, immunologic, or ischemic injury within the allograft suggests that reparative responses can stimulate intrahepatic stem cells to undergo hematopoietic differentiation.	8532704
conjunctiva	Stem Cell Exhaustion	Surgical management of ocular surface disorders using conjunctival and stem cell allografts.	8534667
Neutropenia, Neoplasms, Leukemia, Myelocytic, Acute, Childhood Lymphoblastic Lymphoma	Stem Cell Exhaustion	The scheduled intent-to-treat interim analysis included 115 patients (30%) with prolonged neutropenia after chemotherapy for acute myeloid leukemia, acute lymphoblastic leukemia/high-grade non-Hodgkin's lymphoma, or solid tumors undergoing autologous stem cell transplantation.	8534760
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	The cell surface phenotype of immunoregulatory lymphocytes in bone marrow (BM) and peripheral blood (PB) in myelodysplastic syndrome (MDS), a stem cell disorder, was analyzed.	8534761
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We conclude that this specific subtype of AML, relatively rare when strict criteria are applied, is associated with unique biologic and clinical features and that the high relapse rate associated with conventional therapy makes new treatment approaches involving stem cell transplantation or immunomodulation necessary.	8535217
Hemorrhage, Decreased platelet count	Stem Cell Exhaustion	We administered rhIL-6 to a 43 year old woman who developed marked resistant and prolonged thrombocytopenia with bleeding episodes following autologous peripheral blood stem cell transplantation (APBSCT).	8535229
Chondrosarcoma	Stem Cell Exhaustion	DNA-cytophotometry of the dedifferentiated chondrosarcoma showed an aneuploid stem cell line.	8542510
Stem Cell Factor	Stem Cell Exhaustion	IL-11 alone and combined with r-hu-IL-3, granulocyte-macrophage colony stimulating factor (GM-CSF) and stem cell factor (SCF, c-kit ligand).	8547068
Aplastic Anemia	Stem Cell Exhaustion	Adhesion molecule expression on CD34+ progenitor cells from normal and aplastic anaemia bone marrow.	8547121
Neoplasms	Stem Cell Exhaustion	A phase I trial of interleukin 3 (IL-3) pre-bone marrow harvest with granulocyte-macrophage colony-stimulating factor (GM-CSF) post-stem cell infusion in patients with solid tumors receiving high-dose combination chemotherapy.	8547862
Toxic effect	Stem Cell Exhaustion	While higher doses of IL-3 were associated with more toxicity, they did not appear to enhance the stem cell pool or speed engraftment later.	8547862
Toxic effect, Bone marrow hypocellularity	Stem Cell Exhaustion	The patient experienced no toxicity, had temporary committed progenitor cell engraftment but eventually died from bone marrow failure 1 year post-transplant.	8547872
Myelosuppression	Stem Cell Exhaustion	Serum levels of stem cell factor (SCF), interleukin (IL)-1 alpha, IL-6, IL-3, granulocyte-macrophage CSF (GM-CSF) and G-CSF were analyzed before chemotherapy and during the myelosuppressive stage and correlations between cytokine levels and myelosuppression severity were examined.	8551662
Stem Cell Factor	Stem Cell Exhaustion	We have used a sensitive bioassay to investigate production of granulocyte-colony stimulating factor (G-CSF), granulocyte-macrophage-colony stimulating factor (GM-CSF), interleukin (IL)-3, IL-6 and stem cell growth factor (SCF), by normal and AA stroma in long-term bone marrow culture (LTBMC).	8555053
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Haematological recovery was therefore assessed in 10 PBSC recipients with lymphoma or myeloma in whom monocytes and T cells were depleted by a median of 2.3 and 3.3 logs by CD34+ cell selection using the CEPRATE SC stem cell concentration system and compared with recovery in 59 recipients who received whole PBSC.	8555091
Stem Cell Factor	Stem Cell Exhaustion	Plasma levels of granulocyte-colony stimulating factor (G-CSF), granulocyte/monocyte-colony stimulating factor (GM-CSF), interleukin-6 (IL-6), stem cell factor (SCF) and macrophage-inhibition factor-alpha (MIP-1-alpha) during the transplant procedure were similar whether or not accessory cells were given.	8555091
Bone Marrow Neoplasms	Stem Cell Exhaustion	Patients with any history of histologic evidence of marrow tumor underwent autologous peripheral-blood stem-cell transplantation (PSCT), whereas others underwent autologous bone marrow transplantation (ABMT).	8558200
Tumor necrosis, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Tumour necrosis factor (TNF)-alpha exerts multiple effects on human acute myeloblastic leukaemia (AML) cells in vitro, including (1) synergistic stimulation of proliferation with interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF); (2) inhibition of granulocyte-CSF (G-CSF) and stem cell factor (SCF)-induced growth; (3) suppression of multiplication of clonogenic leukaemic cells; (4) induction of autocrine growth.	8562381
Multiple Myeloma	Stem Cell Exhaustion	Intermediate-dose melphalan (IDM) combined with G-CSF (filgrastim) is an effective and safe induction therapy for autologous stem cell transplantation in multiple myeloma.	8562409
Toxic effect	Stem Cell Exhaustion	The objective of the study was to reduce the toxicity of high-dose melphalan (140 mg/m2) (HDM) while maintaining its cytotoxic efficacy and secondly to ensure the possibility of collecting sufficient numbers of peripheral blood stem cells (PBSC) for transplantation.	8562409
Inflammatory Bowel Diseases	Stem Cell Exhaustion	Effect of c-kit ligand, stem cell factor, on mediator release by human intestinal mast cells isolated from patients with inflammatory bowel disease and controls.	8566835
Hodgkin Disease, HD Term Type, Relapsing course	Stem Cell Exhaustion	Relapsed or refractory Hodgkin's disease (HD) patients were treated with an intensive salvage regimen (MINE) prior to high-dose therapy (HDT) with hematopoietic stem cell support.	8573532
Neoplasms	Stem Cell Exhaustion	Although this pattern of S-phase cells in hyperdiploid MM, belonging to the diploid cell compartment, was observed in three out of four hyperploid cases and although the number of observations is small, S-phase cells may demonstrate an aspect of tumor cell kinetics in hyperploid MM, which has been debated for many years and which indicates the existence of a non-plasmocytic stem cell compartment that feeds the plasmocytoma.	8582241
Hematologic Neoplasms	Stem Cell Exhaustion	Autologous blood stem cell transplantation for haematological malignancy: treatment-related mortality of 2%.	8588769
Hematologic Neoplasms	Stem Cell Exhaustion	To assess the safety of high dose chemotherapy and autologous stem cell transplantation in haematological malignancy.	8588769
Hematologic Neoplasms	Stem Cell Exhaustion	Autologous blood stem cell transplantation to support high dose chemotherapy is a relatively safe procedure and its efficacy is currently being explored in a wide range of haematological malignancies.	8588769
Hodgkin Disease, Multiple Myeloma, Myeloid Leukemia, Chronic, Lymphoma, Non-Hodgkin, Hematologic Neoplasms, BCR gene, Leukemia, Myelocytic, Acute, Acute lymphocytic leukemia	Stem Cell Exhaustion	Forty-eight patients with haematological malignancy were given high dose chemotherapy followed by an infusion of previously cryopreserved autologous peripheral blood stem cells with (patients with acute myeloid leukaemia [AML]) or without (patients with acute lymphoblastic leukaemia [ALL], chronic myeloid leukaemia, non-Hodgkin's lymphoma, Hodgkin's disease and myeloma) autologous bone marrow.	8588769
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Peripheral blood progenitor cell harvesting in multiple myeloma and malignant lymphoma.	8590850
Hematologic Neoplasms	Stem Cell Exhaustion	Peripheral blood progenitor cells are being used increasingly as part of the treatment protocol for a variety of haematological malignancies.	8590850
Stem Cell Factor, PMF Regimen	Stem Cell Exhaustion	These results suggest that leukemic transformation of PMF occurs mainly at the level of myeloid stem cell, and that GM-CSF, IL-3, G-CSF and SCF are major growth factors for the blast cells in these cases.	8590852
Lymphoma, Non-Hodgkin, Familial, Lymphoproliferative Disorders	Stem Cell Exhaustion	The rare occurrence of lymphoproliferative disorder in the course of PV, may indicate that in a minority of patients, clonal expansion of an abnormal pluripotent haemopoetic stem cell could be responsible for both the PV and the NHL.	8590854
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), expression of the hematopoietic stem cell marker CD34 has been associated with a poorer prognosis.	8598230
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A stem cell phenotype is more commonly expressed on precursor cells from patients with MDS than from patients with AML.	8598230
Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Familial, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We have evaluated CD34+ cell positive selection from granulocyte-colony stimulating factor (G-CSF)-mobilized peripheral blood progenitor cells (PBPC) in 26 patients with either multiple myeloma (MM, n = 18) or follicular non-Hodgkin's lymphoma (NHL, n = 8).	8602984
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Feasibility of peripheral blood progenitor cell harvest and transplantation in patients with poor-risk myelodysplastic syndromes.	8602999
Aplastic Anemia	Stem Cell Exhaustion	We investigated the effects of granulocyte-macrophage colony-stimulating factor, interleukin-3, stem cell factor, interleukin-6, and granulocyte colony-stimulating factor (G-CSF) alone, and in combination, on the clonogenic potential of normal and aplastic anemia (AA) bone marrow mononuclear cells (BMMC and CD34+ cells.	8605332
Aplastic Anemia	Stem Cell Exhaustion	Aplastic anemia: evidence for dysfunctional bone marrow progenitor cells and the corrective effect of granulocyte colony-stimulating factor in vitro.	8605332
Specialty Type - cancer, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Expression of the multidrug resistance (MDR-1) gene product, P-glycoprotein (P-170), and the stem cell antigen, CD34, at diagnosis were determined using monoclonal antibodies (MoAbs) MRK-16 and 12.8 respectively, in 130 pediatric acute myeloid leukemia (AML) patients entered onto Childrens Cancer Group (CCG) study CCG-2891.	8609715
Hemoglobinopathies	Stem Cell Exhaustion	Lack of evidence of permanent engraftment after in utero fetal stem cell transplantation in congenital hemoglobinopathies.	8610414
Chimerism	Stem Cell Exhaustion	The use of fetal hematopoietic stem cells for in utero transplantation to create permanent hematochimerism represents a new concept in fetal therapy.	8610414
Chimerism	Stem Cell Exhaustion	Thus, the administration of fetal stem cells to fetal recipients after the 12th week of gestation did not result in permanent hematochimerism.	8610414
Childhood Breast Carcinoma	Stem Cell Exhaustion	High-dose cyclophosphamide, carboplatin, and etoposide with autologous stem cell rescue in patients with breast cancer.	8610643
Breast Carcinoma, Toxic effect	Stem Cell Exhaustion	This study was designed to establish the toxicity and response rates o observed with a combination of high-dose cyclophosphamide, carboplatin, and etoposide with stem cell rescue in patients with breast carcinoma.	8610643
Multiple Myeloma	Stem Cell Exhaustion	Peripheral blood progenitor cell collections in multiple myeloma: predictors and management of inadequate collections.	8611448
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Thirty-seven patients with previously treated multiple myeloma (MM) underwent peripheral blood progenitor cell (PBPC) collection following high-dose cyclophosphamide and GM-CSF or sequential IL-3 and GM-CSF.	8611448
Lymphoma, Non-Hodgkin, Familial, HD Term Type	Stem Cell Exhaustion	The actuarial incidence of MDS/AML plateaued at 2.1% +/- 0.8% at 9 years and was seen most often in older patients receiving autologous peripheral blood stem cells for HD or NHL.	8611687
Leukemia, Myelocytic, Acute, Acute leukemia	Stem Cell Exhaustion	To further address the role of IL-9 in the development of acute leukemia, we evaluated the proliferative response of three leukemic cell lines and 32 primary samples from acute myeloblastic leukemia (AML) patients to recombinant human (rh)-IL-9 alone and combined with rh-IL-3, granulocyte-macrophage CSF (GM-CSF), and stem cell factor ([SCF] c-kit ligand).	8611712
Leukemia, Myelocytic, Acute, BCR gene	Stem Cell Exhaustion	These findings suggest that the cell of origin of secondary AML and ALL with 11q23 rearrangement is an immature haemopoietic progenitor cell.	8616034
Chronic myeloproliferative disorder, Leukemia, Myelocytic, Acute, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Although t(7;11)(p15;p15) has been reported mainly in acute myelogenous leukemia (AML), it can be occasionally found in so-called stem cell diseases such as chronic myelogenous leukemia or chronic myeloproliferative disorders.	8616792
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Therefore, t(7;11)(p15;p15) might affect trilineage progenitors or stem cells as well as myeloid lineage cells, subsequently resulting in AML with T-MDS, as in our case reported here.	8616792
S100A4 protein, human	Stem Cell Exhaustion	This study associates trisomy 13 with malignant transformation of myeloid progenitor cells.	8618437
Multiple Myeloma	Stem Cell Exhaustion	High-dose therapy followed by autologous hematopoietic stem-cell infusion for patients with multiple myeloma.	8622058
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	To evaluate the outcome of patients with multiple myeloma (MM) who received high-dose therapy followed by autologous bone marrow (BM) or peripheral-blood stem-cell (PBSC) infusion.	8622058
Myeloproliferative disease, DPM1 gene	Stem Cell Exhaustion	In the present study, the ability of peripheral blood (PB) progenitor cells to form granulocyte-macrophage (GM) colonies spontaneously in methylcellulose was investigated in healthy controls and patients with myeloproliferative disorders (MPDs).	8628019
Tumor necrosis, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In contrast to spontaneous blast proliferation, in the presence of exogenous hematopoietic growth factors (granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, interleukin 3, tumor necrosis factor alpha, stem cell factor), IL1 inhibition caused either increased or decreased AML blast proliferation depending on the individual patient.	8632679
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	When AML blasts were cultured with stem cell factor plus granulocyte-macrophage colony-stimulating factor, IL1 inhibition significantly increased AML blast proliferation.	8632679
Lymphoma, Malignant Neoplasms	Stem Cell Exhaustion	The growth stimulatory effects of interleukin-3 (IL-3) on normal hematopoietic progenitor cells are well established, and clinical trials using IL-3 after bone marrow transplantation for various malignancies including lymphomas are frequently conducted.	8634414
Traumatic	Stem Cell Exhaustion	Stem cell transplants are fast evolving as an alternative to bone marrow transplants because they are less traumatic and easier to perform.	8635126
Labor (Childbirth)	Stem Cell Exhaustion	The procedure is less labor intensive insofar as it does not require separation and concentration of stem cells.	8635126
Stem Cell Factor, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This study examined the effects of recombinant human stem cell factor (SCF) alone or in combination with colony-stimulated factors (CSFs) on colony formation of leukemic progenitors obtained from 29 acute myeloid leukemia (AML) patients.	8637237
Tumor necrosis	Stem Cell Exhaustion	Co-incubation of M-07e with various cytokines and TPO showed additive proliferative effects for interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) and synergistic responses for stem cell factor (SCF), interferon (IFN)-alpha, and to a lesser extent for IFN-gamma and tumor necrosis factor (TNF)-alpha.	8637239
Rheumatoid Arthritis	Stem Cell Exhaustion	To examine the capacity of bone marrow progenitor cells to generate CD14+ cells, in order to assess the role of bone marrow in the pathogenesis of rheumatoid arthritis (RA).	8639181
Rheumatoid Arthritis	Stem Cell Exhaustion	The spontaneous generation of CD14+ cells from bone marrow CD14- progenitor cells was accelerated in RA patients compared with control patients.	8639181
Rheumatoid Arthritis	Stem Cell Exhaustion	These observations strongly support the hypothesis that the accelerated generation of CD14+ cells from bone marrow progenitor cells and the accelerated maturation of such CD14+ cells into HLA-DR+ cells play an important role in the pathogenesis of RA.	8639181
Neoplasms	Stem Cell Exhaustion	Archival tissue was immunohistochemically stained for the p53 tumor suppressor gene product, the inhibitor of apoptosis (bcl-2), the stem cell marker CD34, the cell adhesion molecules CD44H and CD44v6, and a marker of cellular proliferation (Ki-67).	8639294
Carcinoma of larynx	Stem Cell Exhaustion	This study also indicates that the stem cell marker CD34 is rarely expressed by laryngeal carcinoma cells.	8639294
THM gene, Rheumatoid Factor	Stem Cell Exhaustion	Evaluation included a medical and drug exposure history, a physical examination, a chest x-ray or computed tomography to rule out thymoma, lymphocyte immunophenotype studies, anti-nuclear antibody and rheumatoid factor determinations, marrow cytogenetics, and marrow progenitor cell cultures.	8639856
Breast Carcinoma	Stem Cell Exhaustion	One hundred seventy-eight invasive breast carcinomas (Stage 1 and 2, mean follow-up: 71 months) were immumostained for the presence of CD34, the human hematopoietic progenitor cell antigen also present in endothelium, and EA was quantitated within 5 adjacent 20X fields (0.74 mm2).	8640673
Myeloid-Lymphoid Leukemia Protein	Stem Cell Exhaustion	The presence of myeloid and lymphoid markers suggests the transformation of an early stem cell.	8642864
Embryonal Rhabdomyosarcoma, Sarcoma - category (morphologic abnormality)	Stem Cell Exhaustion	Reports of a similar translocation in an embryonal rhabdomyosarcoma (RMS) and in a dedifferentiated sarcoma with both rhabdomyosarcomatous and osteosarcomatous elements suggest that this translocation can arise in a primitive mesenchymal stem cell that can differentiate along at least these three pathways.	8646746
Multiple Myeloma	Stem Cell Exhaustion	The aims of the current study were to evaluate in patients with high-risk multiple myeloma (MM) the feasibility and usefulness of high-dose chemotherapy or chemoradiotherapy followed by hematopoietic stem-cell support with autologous peripheral-blood progenitor cells (PBPC) harvested after high-dose cyclophosphamide (HDCYC).	8648388
Multiple Myeloma	Stem Cell Exhaustion	Autologous peripheral-blood progenitor-cell support following high-dosechemotherapy or chemoradiotherapy in patients with high-risk multiple myeloma.	8648388
Acute heart failure	Stem Cell Exhaustion	One patient died of acute cardiac failure after reinfusion of PBPC; three patients did not respond after autologous blood progenitor cell transplantation (ABPCT), while the other 68 patients achieved either a complete response (CR; n = 32) or partial response (PR; n = 36).	8648388
Complex Karyotype, Failure	Stem Cell Exhaustion	CD34 stem-cell phenotype, poor performance status, and high cytogenetic complexity score were independent covariates of failure to achieve remission.	8648393
Cessation of life	Stem Cell Exhaustion	Very complex karotype combined with CD34 stem-cell phenotype to predict induction death in 67% of cases (P = .0003).	8648393
Colorectal Carcinoma	Stem Cell Exhaustion	We concluded that these characteristics of colorectal carcinomas may be related to their origin as multipotential endodermal stem cells.	8651858
Depression, CTCAE, Paroxysmal nocturnal hemoglobinuria, leukemia	Stem Cell Exhaustion	PNH exhibits an acquired stem cell disorder, a clonal expansion of affected cells, concomitant depression of normal hematopoiesis in bone marrow (BM), and, although infrequently, the development of leukemia.	8652806
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	We report here that CD34+ hematopoietic progenitor cells of PNH-BM yielded blood cells of three lineages with PNH phenotype alone when transplanted into sublethally irradiated severe combined immunedeficient mice.	8652806
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	This in vivo model defines the preferential hematopoiesis of pluripotent PNH progenitor cells, indicating the intrinsic growth abnormality of PNH clone.	8652806
Acute biphenotypic leukemia	Stem Cell Exhaustion	In contrast, all Ph+ BCP-ALLs and biphenotypic acute leukemias, which may represent the transformation of multipotent hemopoietic stem cells, had undergone VHDHJH recombination.	8652839
Pulmonary Infiltrate, Multiple Myeloma	Stem Cell Exhaustion	A 45-year-old male with multiple myeloma who underwent autologous peripheral stem cell transplantation subsequently developed bilateral pulmonary infiltrates.	8669193
Decreased platelet count	Stem Cell Exhaustion	Refractory thrombocytopenia due to anti-PLA1 antibodies following autologous peripheral blood stem cell transplantation: case report and review of literature.	8673043
Breast Carcinoma, Decreased platelet count	Stem Cell Exhaustion	A 43-year-old woman developed life-threatening refractory thrombocytopenia following autologous peripheral blood stem cell transplantation for metastatic breast carcinoma.	8673043
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Myelosuppressive chemotherapy to mobilize normal stem cells in chronic myeloid leukemia.	8673050
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Ten patients with Ph+ chronic myeloid leukemia (CML) were treated with idarubicin, cytarabine and etoposide followed by G-CSF to harvest Ph-negative progenitor cells.	8673050
Neoplasms, Metaplastic	Stem Cell Exhaustion	These cell types are resident in the normal prostate or appear in metaplastic lesions, and their presence in the macaque tumors is consistent with differentiation of a stem cell along multiple phenotypic pathways.	8685056
Hodgkin Disease, Multiple Myeloma, Myeloid Leukemia, Chronic, Lymphoma, Non-Hodgkin, Acute leukemia	Stem Cell Exhaustion	One hundred consecutive autologous stem cell transplants are reported: Non-Hodgkin's lymphoma 51 cases, Hodgkin's disease 27 cases, acute leukaemia 14 cases, multiple myeloma seven cases and chronic myeloid leukaemia one case.	8686009
Pancytopenia	Stem Cell Exhaustion	The patients transplanted with blood stem cells had significantly shorter duration of pancytopenia, and hospital stay, but their disease-free survival was not longer than that of a comparable group of bone marrow transplanted patients.	8686009
Neutropenia, Decreased platelet count	Stem Cell Exhaustion	Six patients were transplanted with purified CD34+ cells (selected by avidity column (Ceprate (R)), and had duration of thrombocytopenia and hospital stay similar to the patients transplanted with unmanipulated blood stem cells, but slightly longer duration of neutropenia.	8686009
Multiple Myeloma	Stem Cell Exhaustion	Autologous bone marrow and peripheral blood stem cell transplantation in multiple myeloma.	8689434
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	In a few cases with myelodysplastic syndrome, a multipotent stem cell disorder, trisomy 13 has also been reported.	8691571
Hematological Disease	Stem Cell Exhaustion	From these standpoints, there might be a possibility that trisomy 13 as a sole abnormality in hematologic disorders would be related to tumorigenesis in the levels of multipotent stem cells.	8691571
Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Syngeneic bone marrow transplantation without conditioning in a patient with paroxysmal nocturnal hemoglobinuria: in vivo evidence that the mutant stem cells have a survival advantage.	8695823
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	Thus, these studies contribute in vivo data in support of the hypothesis that PNH arises as a consequence of a pathological process that selects for hematopoietic stem cells that are GPI-AP-deficient.	8695823
Tumor necrosis, Leukemia, Myelocytic, Acute, leukemia	Stem Cell Exhaustion	IL1RA release from AML blasts was also increased by stem cell factor, tumour necrosis factor alpha (TNF alpha), granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor, whereas interleukin 3, interleukin 6, leukaemia inhibitory factor and granulocyte colony-stimulating factor did not significantly alter IL1RA release.	8698137
Acute lymphocytic leukemia	Stem Cell Exhaustion	[Successful syngeneic transplantation using G-CSF-stimulated peripheral hematopoietic progenitor cells combined with post-transplant administration of G-CSF in a patient with acute lymphatic leukemia].	8701254
Acute lymphocytic leukemia	Stem Cell Exhaustion	A 45-year-old male with acute lymphoblastic leukemia in first remission was successfully transplanted with G-CSF (filgrastim)-mobilized syngeneic PBPC (peripheral blood progenitor cells).	8701254
Fever	Stem Cell Exhaustion	Short-course intravenous antibiotics with oral quinolone prophylaxis in the treatment of neutropenic fever in autologous bone marrow or peripheral blood progenitor cell transplant recipients.	8701702
Fever	Stem Cell Exhaustion	The effectiveness of short-course intravenous antibiotics concurrent with prophylactic oral ciprofloxacin in the treatment of neutropenic fever was studied in 81 patients undergoing autologous bone marrow or peripheral blood progenitor cell transplantation (ABMT or PBPCT).	8701702
Aplastic Anemia	Stem Cell Exhaustion	To characterize the persistent abnormalities of hematopoiesis in aplastic anemia (AA) after immunosuppression with antilymphocyte globulin (ALG), we analyzed the quantity, phenotype, and growth properties of hematopoietic progenitor cells in 13 patients who received ALG treatment.	8701944
Stem Cell Factor	Stem Cell Exhaustion	The purified CD34+ cells were cultured for 14 days with various combinations of cytokines, including recombinant human macrophage colony-stimulating factor (rM-CSF), granulocyte-CSF (rG-CSF), granulocyte-macrophage-CSF (rGM-CSF), interleukin-3 (rIL-3), and stem cell factor (SCF; a ligand for c-kit) in serum-free medium.	8704190
MDF AttributeType - Number, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	The clonal growth of progenitor cells from myelodysplastic syndromes (MDS) can be subdivided into four growth patterns: (1) normal, (2) no growth or low plating efficiency, (3) low colony and high cluster number, and (4) normal or high colony number with a large number of clusters.	8704190
PAFAH1B1 wt Allele	Stem Cell Exhaustion	In a search for a role for cytokines in leukemic-type growth of MDS progenitor cells, marrow CD34+ cells were purified up to 94% for 8 normal individuals and 88% for 12 MDS patients, using monoclonal antibodies and immunomagnetic microspheres (MDS CD34+ cells).	8704190
PAFAH1B1 wt Allele, Stem Cell Factor	Stem Cell Exhaustion	SCF is present in either normal or MDS plasma at a level of nanograms per milliliter, and this physiologic concentration of SCF can stimulate progenitor cells.	8704190
Stem Cell Factor	Stem Cell Exhaustion	This means that progenitor cells are continuously exposed to stimulation by SCF in vivo and that MDS leukemic cells have a growth advantage over normal blast cells.	8704190
Hematologic Neoplasms	Stem Cell Exhaustion	Thirty-one patients (median age, 44 years) with advanced hematologic malignancies were given thiotepa 15 mg/kg, and cyclophosphamide 120 (n = 14) or 150 (n = 17) mg/kg followed by unfractionated peripheral blood stem cell transplants (PBSCT) from genotypically identical siblings (n = 28) or one antigen mismatched family donor (n = 3).	8704195
Acute GVH disease	Stem Cell Exhaustion	We conclude that cryopreserved umbilical cord blood from HLA-matched and mismatched unrelated donors is a sufficient source of transplantable hematopoietic stem cells with high probability of donor derived engraftment and low risk of refractory severe acute graft-versus-host disease.	8704232
Hematologic Neoplasms, Toxic effect	Stem Cell Exhaustion	We have investigated the toxicity of dose-escalation of BCNU, etoposide and melphalan ('BEM') chemotherapy with autologous stem cell transplantation in patients with haematological malignancies.	8704683
Hematologic Neoplasms	Stem Cell Exhaustion	Seventy-two patients with haematological malignancies were treated with BCNU (600 mg/m2, 450 mg/m2 or 300 mg/m2), etoposide 2 g/m2 and melphalan 140 mg/m2 followed by autologous bone marrow transplantation (ABMT), n = 51, or autologous peripheral blood progenitor cell transplantation (APBPCT), n = 21.	8704683
Thrombus	Stem Cell Exhaustion	Therefore, patients undergoing stem cell transplantation may be at prolonged risk of thrombotic and other complications.	8704697
Deficiency	Stem Cell Exhaustion	Further studies to determine the risk of prolonged deficiency based on stem cell source need to be performed.	8704697
Disease	Stem Cell Exhaustion	Several reports have suggested EpoR abnormalities in both types of stem cell disorders.	8709617
leukemia, Acute leukemia	Stem Cell Exhaustion	Biphenotypic acute leukaemias comprise a heterogeneous group of leukaemias involving pluripotent stem cells.	8709632
Hematologic Neoplasms	Stem Cell Exhaustion	Transplantation of allogeneic CD34+ peripheral blood stem cells (PBSC) in patients with advanced hematologic malignancy.	8722333
Pulmonary Complication	Stem Cell Exhaustion	Cardiopulmonary complications are a major cause of morbidity and mortality in patients undergoing high-dose therapy with stem cell transplant support.	8722355
Demyelinating Diseases	Stem Cell Exhaustion	In this study, the antigenic expression of CD34, a 110 kDa glycoprotein which is expressed on human haemopoietic progenitor cells and vascular endothelium, has been assessed in a variety of neuropathological conditions, including infectious and demyelinating disease.	8732185
Lymphoid neoplasm	Stem Cell Exhaustion	From April 1993 to September 1993, 15 patients with lymphoid or solid neoplasms underwent 16 non-cryopreserved peripheral stem cell transplantation courses using the ICE (ifosfamide, carboplatin, etoposide) program.	8733702
Hodgkin Disease	Stem Cell Exhaustion	A 29-year-old male was treated for recurrent Hodgkin's disease with autologous bone marrow and peripheral blood stem cell transplantation.	8733711
Lymphoma	Stem Cell Exhaustion	Autologous peripheral blood stem and progenitor cells transplantation as a valid treatment approach in recurrent, refractory lymphoma.	8744694
Multiple Myeloma	Stem Cell Exhaustion	Sequential high-dose treatment with peripheral blood progenitor cell transplantation in patients with multiple myeloma.	8747987
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	In June 1992, we started a dose-escalated cytotoxic therapy with peripheral blood progenitor cell (PBPC) transplantation in patients with chemosensitive multiple myeloma (MM).	8747987
Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	One patient received induction and consolidation treatment, and the protocol for peripheral blood stem cell transplantation.	8752996
Leukemia, Myelomonocytic, Chronic, Disease	Stem Cell Exhaustion	These findings suggest that some cases of infantile CMML are clonal disorders arising in a pluripotent stem cell that can also differentiate along the lymphoid cell lineage.	8756090
Corneal Opacity	Stem Cell Exhaustion	Limbal epithelial autograft Limbal epithelial autograft transplantation applied for reconstruction of palisades of Vogt to provide new stem cell source for injured limbus is a reasonable therapeutic method for treatment of vascularized corneal opacity caused by chemical burns.	8758381
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Factors for rapid and sustained hematopoietic reconstitution by circulating progenitor-cell transplantation in non-Hodgkin's lymphoma.	8765429
Lymphadenopathy, Sinus histiocytosis	Stem Cell Exhaustion	Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) is a disease of bone marrow stem cell origin which primarily affects lymph nodes.	8771474
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The effect of the mast cell growth factor (MGF), also known as stem cell factor, steel factor, and kit ligand, alone or in combination with other GFs on clonogenic blast cell growth in 23 patients with acute myeloblastic leukemia (AML) was investigated.	8774615
Nephroblastoma	Stem Cell Exhaustion	High dose consolidation with autologous stem cell rescue (ASCR) for nephroblastoma initially treated according to the SIOP 9/GPOH trial and study.	8776705
Neoplasms	Stem Cell Exhaustion	Both the low ratio of premortem versus initial PSA, which may reflect an increase of stem cell fraction, and the PSA doubling time after relapse, which seems similar to or shorter than that of untreated cases, will indicate an aggressive potential of hormone-refractory tumors.	8776967
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	CLL is also adequately fitted by a model with three mutations, and the mutation rates and the variation in the stem cell population numbers implied by the three-mutation model are more plausible than those of the two-mutation model.	8783438
Thalassemia, Common Variable Immunodeficiency, Panhypogammaglobulinemia	Stem Cell Exhaustion	The simultaneous presence of globin synthesis abnormalities and panhypogammaglobulinemia suggests that a common insult at the stem cell level could contribute to the development of CVID and acquired thalassemia.	8790601
Multiple Myeloma	Stem Cell Exhaustion	Factors influencing collection of peripheral blood stem cells in patients with multiple myeloma.	8807097
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	This study was performed to determine the factors influencing the collection of autologous peripheral blood stem cells (PBSC) in patients with multiple myeloma (MM) who had disease which had progressed after an initial response or who had refractory disease.	8807097
malignant disease	Stem Cell Exhaustion	Phase II study of high-dose busulfan, melphalan and thiotepa with autologous peripheral blood stem cell support in patients with malignant disease.	8807098
Toxic effect	Stem Cell Exhaustion	The purpose of this study was to determine the toxicities and potential effectiveness of high-dose busulfan, melphalan and thiotepa (Bu/Mel/TT) followed by autologous peripheral blood stem cell (PBSC) infusion in patients with a variety of diseases.	8807098
Acute GVH disease	Stem Cell Exhaustion	Severe acute graft-versus-host disease of conjunctivae after allogeneic blood progenitor cell infusion.	8807133
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	These findings suggest that the mechanisms causing mobilization of leukemic stem cells in untreated CML patients may affect their normal counterparts.	8822936
Specialty Type - cancer	Stem Cell Exhaustion	We investigated the ability of granulocyte colony-stimulating factor (G-CSF) to protect progenitor cells in the bone marrow of cancer patients from the toxic effects of subsequent treatments with chemotherapeutic agents.	8827017
Decreased platelet count	Stem Cell Exhaustion	The observation of more severe thrombocytopenia in patients treated with prechemotherapy G-CSF led us to conclude that the proliferation of progenitor cells was still increased 48 hours after the last dose of G-CSF and that the administration of chemotherapy at or within this time period actually worsens the toxic effects on bone marrow.	8827017
Hematologic Neoplasms, Toxic effect	Stem Cell Exhaustion	Phase I-II study of high-dose busulfan and cyclophosphamide followed by autologous peripheral blood stem cell transplantation for hematological malignancies: toxicities and hematopoietic recovery.	8831989
Hematologic Neoplasms, Toxic effect, Neoplasms	Stem Cell Exhaustion	In a phase I-II study, we evaluated toxicities, tolerability, pace of engraftment, and tumor responses to high-dose bulsulfan and cyclophosphamide followed by autologous peripheral blood stem cell transplantation in patients with hematological malignancies.	8831989
Hematologic Neoplasms	Stem Cell Exhaustion	We treated 51 patients with various hematological malignancies involving the bone marrow with busulfan (16 mg/kg) and cyclophosphamide (120 mg/kg) followed by reinfusion of autologous peripheral blood stem cells.	8831989
Neoplasms	Stem Cell Exhaustion	Recently, peripheral blood progenitor cell (PBPC) harvest have been preferred over autologous bone marrow (BM) harvests due to reduced engraftment time, ease of attainment, and presumptive reduction of occult tumor involvement.	8832002
Glioma	Stem Cell Exhaustion	High-dose BCNU and autologous progenitor cell transplantation given with intra-arterial cisplatinum and simultaneous radiotherapy in the treatment of high-grade gliomas: benefit for selected patients.	8832007
Porphyria, Erythropoietic, UROS gene	Stem Cell Exhaustion	Successful cord blood stem cell transplantation for congenital erythropoietic porphyria (Gunther's disease).	8832020
Rheumatoid Arthritis, Tumor necrosis	Stem Cell Exhaustion	Due to the elevated levels of hematopoietically active cytokines such as tumor necrosis factor (TNF) and granulocyte macrophage colony stimulating factor (GMCSF) in rheumatoid arthritis (RA) serum and synovium, the increased bone marrow activity in RA, and the effectiveness of GMCSF in mobilizing progenitor cell release from the bone marrow into the periphery, we hypothesized that hematopoietic progenitors are altered in the peripheral blood (PB) of patients with RA.	8832979
Rheumatoid Arthritis	Stem Cell Exhaustion	Flow cytometry assisted cell surface analysis was employed to compare the distribution of myeloid (CD34+CD33+), B lymphoid (CD34+CD10+), and erythroid (CD34+CD71+) committed progenitor cell subsets in the PB of healthy controls and patients with RA.	8832979
Rheumatoid Arthritis, Disease remission	Stem Cell Exhaustion	Only those patients with RA exhibiting clinically active disease (RA-A) demonstrated increases in myeloid and B lymphoid progenitor cell subsets.	8832979
Rheumatoid Arthritis, "Sjogrens Syndrome	Stem Cell Exhaustion	Distinct alterations in lineage committed progenitor cells exist in the peripheral blood of patients with rheumatoid arthritis and primary Sjogren's syndrome.	8832979
Multiple Myeloma	Stem Cell Exhaustion	Technetium-99m sestamibi scanning in multiple myeloma stem cell transplantation.	8833402
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We report the use of technetium-99m sestamibi (MIBI) in a patient with multiple myeloma (MM) undergoing peripheral blood stem cell (PBSC) transplantation.	8833402
Trichoepithelioma, Eccrine dermal cylindroma	Stem Cell Exhaustion	The occurrence of cylindroma and trichoepithelioma in a single nevoid plaque from a patient with Brooke-Spiegler syndrome implies an alteration in the stem cells of the folliculosebaceous-apocrine unit and could be characteristic of the disorder.	8835176
Amyloidosis	Stem Cell Exhaustion	Dose-intensive melphalan with blood stem cell support for the treatment of AL amyloidosis: one-year follow-up in five patients.	8839879
Amyloidosis	Stem Cell Exhaustion	Dose-intensive chemotherapy with intravenous melphalan and growth-factor-mobilized blood stem cell support is feasible therapy for patients with AL amyloidosis, even when there is clinical evidence of cardiac involvement.	8839879
Hairy Cell Leukemia, Lymphoproliferative Disorders	Stem Cell Exhaustion	Hairy cell leukemia is a rare chronic lymphoproliferative disorder originating probably in a pluripotent stem cell.	8843970
Hairy Cell Leukemia	Stem Cell Exhaustion	Taken together these data suggest a decreased activity of red cell antioxidant enzymes in hairy cell leukemia and support a pluripotent stem cell defect of these abnormalities.	8843970
Malignant tumor of colon	Stem Cell Exhaustion	[Chemohyperthermic peritoneal perfusion and high-dose chemotherapy followed by peripheral blood stem cell transplantation in advanced colon cancer--a case report].	8854810
Malignant neoplasm of cecum, Krukenberg Tumor	Stem Cell Exhaustion	A 49-year-old woman who suffered from caecal cancer in 1988 underwent chemohyperthermic peritoneal perfusion for peritoneal and ovarian metastases in 1990, and high dose chemotherapy (HDC) with peripheral blood stem cell transplantation (PBSCT) for lung metastases in 1995.	8854810
Malignant Neoplasms	Stem Cell Exhaustion	Between April 1988 and March 1994 a total of 23 patients with haematological or non-haematological malignancies received serial peripheral blood stem cell (PBSC) mobilization to attain sufficient harvest for PBSC transplant at our institution.	8857936
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In vivo mobilization of karyotypically normal peripheral blood progenitor cells in high-risk MDS, secondary or therapy-related acute myelogenous leukaemia.	8857949
Hematopoietic Neoplasms	Stem Cell Exhaustion	CD69 expression on primitive progenitor cells and hematopoietic malignancies.	8864178
Myeloid neoplasm	Stem Cell Exhaustion	To further characterize the distribution and understand the potential biological role of the molecule in normal and malignant hematopoiesis, we used a novel high affinity anti-CD69 mAb (UN6) and analyzed hematopoietic progenitor cells together with a panel of myeloid and lymphoid malignancies.	8864178
Pregnancy Complications, Infectious	Stem Cell Exhaustion	The objective of this study was to define the incidence, type and timing of early infectious complications, occurring within the first 30 days, in autologous bone marrow transplant (autoBMT) recipients over a 45-month period, and in addition to assess the effects of growth factors and primed peripheral blood progenitor cells on the rate of infectious complications.	8864433
Neutropenia, Septicemia, Infection, Mycoses	Stem Cell Exhaustion	The use of growth factors and primed peripheral blood progenitor cells was associated with a shorter duration of neutropenia; a decrease in the overall incidence of infections, particularly septicemia and fungal infections; a shorter length of stay in the hospital and a lower mortality rate in the first 30 days after transplantation.	8864433
Neutropenia, Communicable Diseases	Stem Cell Exhaustion	The critical factor associated with the occurrence of any early infection was the duration of neutropenia, which was significantly shortened by the use of growth factors and peripheral blood progenitor cells.	8864433
Lymphoma	Stem Cell Exhaustion	Granulocyte-macrophage colony-stimulating factor accelerates hematopoietic recovery after autologous bone marrow or peripheral blood progenitor cell transplantation and high-dose chemotherapy for lymphoma.	8864437
Lymphoma	Stem Cell Exhaustion	The use of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) as an adjunct to autologous bone marrow transplantation (ABMT) or peripheral blood progenitor cell (PBPC) transplantation was evaluated in 59 lymphoma patients.	8864437
Ewings sarcoma, Ewings sarcoma-primitive neuroectodermal tumor (PNET)	Stem Cell Exhaustion	High-dose melphalan +/- total body irradiation and autologous hematopoietic stem cell rescue for adult patients with Ewing's sarcoma or peripheral neuroectodermal tumor.	8864440
Ewings sarcoma	Stem Cell Exhaustion	The role of high-dose therapy and autologous stem cell transplantation (ASCT) in the treatment of patients with Ewing's sarcoma (EWS) remains uncertain.	8864440
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Allogeneic bone marrow and peripheral stem cell transplantation from a haplo-identical mother and CD34 positive selection for CML.	8864462
Keratopathy, Kidney Failure, Blepharoconjunctivitis, Keratoconus, Eczema, CTCAE	Stem Cell Exhaustion	The 40 kp in group B were threatened by severe ocular surface disorders (without severe limbal stem cell insufficiency) and by immune reactions (atopic keratopathy, keratoconus with severe endogenous eczema or chronic blepharokeratoconjunctivitis).	8871161
Toxic Epidermal Necrolysis, Burn injury	Stem Cell Exhaustion	In the 45 kp of group C resurfacing problems from severe limbal stem cell insufficiency and immune reactions were anticipated (severe burns, pseudopemphigoid or Lyell syndrome).	8871161
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myelogenous leukemia (CML) is a clonal disorder of the hematopoietic stem cell characterized by a chimeric BCR/ABL gene giving rise to a 210-kD fusion protein with dysregulated tyrosine kinase activity.	8874208
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Preincubation of CML and normal marrow with genistein (200 mumol/ L for 1 to 18 hours) induced a time-dependent suppression of progenitor cell growth, while sparing a substantial proportion of long-term culture-initiating cells (LTC-IC) from CML (range, 91% +/- 9% to 32% +/- 3%) and normal marrow (range, 85% +/- 8% to 38% +/- 9%).	8874208
Aggressive Systemic Mastocytosis	Stem Cell Exhaustion	The presence of membrane-bound stem cell factor on highly immature nonmetachromatic mast cells in the peripheral blood of a patient with aggressive systemic mastocytosis.	8876560
Stem Cell Factor	Stem Cell Exhaustion	The peripheral blood contained 1% to 3% nonmetachromatic mononuclear cells with eccentric nuclei that expressed the mast cell proteases, tryptase and carboxypeptidase A, along with c-kit, stem cell factor (SCF), and high-affinity IgE receptor (Fc epsilon RI), but not chymase.	8876560
Graft-vs-Host Disease	Stem Cell Exhaustion	In utero transplantation of stem cells is a therapy with remarkable advantages: (a) tolerance induction due to the immune immaturity of the host, (b) lack of graft-versus-host disease due to the immaturity of the donor, (c) ideal isolation of the fetus in the maternal uterus, and (d) an optimal environment for donor fetal cell development in the vicinity of host fetal cells and growth factors.	8876606
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Response of the blast stem cells of acute myeloblastic leukemia to G-CSF, GM-CSF, or the ligand for C-KIT, alone or in combination.	8878730
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Because the response of blast stem cells in culture to growth factors might influence the contribution of factor to clinical outcome, we studied 42 patients with AML or severe myelodysplasia.	8878730
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Eleven patients with advanced multiple myeloma (MM) received syngeneic marrow (n = 10) or peripheral blood stem cell (n = 1) transplants following cyclophosphamide (CY) and total body irradiation (TBI) (n = 8), busulfan (Bu) and CY (n = 1), Bu, CY and TBI (n = 1) or Bu, melphalan and thiotepa (n = 1).	8879613
Neoplasms	Stem Cell Exhaustion	One reason for relapse after high-dose tumor therapy with subsequent autologous stem cell transplantation is tumor cell contamination of the graft.	8879616
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The hemopoietic stem cell marker CD34 has been reported to be a useful predictor of treatment outcome in acute myeloid leukemia (AML).	8895688
Cytomegalovirus antigen assay	Stem Cell Exhaustion	Cytomegalovirus pp65 antigenemia after autologous marrow and peripheral blood stem cell transplantation.	8896489
Cytomegalovirus Infections	Stem Cell Exhaustion	In a prospective study, the cytomegalovirus (CMV) pp65 antigenemia assay was compared with detection of CMV by blood culture in 67 consecutive CMV-seropositive patients undergoing autologous marrow or peripheral blood stem cell transplantation.	8896489
Small cell carcinoma of lung	Stem Cell Exhaustion	High-dose chemo-radiotherapy cycles for LD small cell lung cancer patients using G-CSF and blood stem cells.	8899169
Carcinoma of lung	Stem Cell Exhaustion	Treatment intensification which includes high-dose induction improves survival of lung carcinoma patients treated by high-dose chemotherapy with hematopoietic progenitor cell rescue but does not prevent high rate of relapses.	8899171
Aplastic Anemia, Abscess	Stem Cell Exhaustion	Renal Salmonella enteritidis abscess in a patient with severe aplastic anemia after allogeneic stem cell transplantation.	8899201
Renal abscess, Aplastic Anemia	Stem Cell Exhaustion	We describe an unusual case of a renal abscess by Salmonella enteritidis in a 32-year-old man with severe aplastic anemia undergoing allogeneic stem cell transplantation.	8899201
Malignant Neoplasms	Stem Cell Exhaustion	One can hypothesize that different risk factors act on different stem cells and induce lymphoid malignancies belonging to different histologic sub-types.	8900420
Myeloid Stem Cell, Thrombocythemia, Essential	Stem Cell Exhaustion	Essential thrombocythemia (ET) is a clonal disorder of the myeloid stem cell that causes pathologic expansion of the megakaryocytic elements in the bone marrow, with a persistent increase in the platelet count.	8900853
Aleukemic mast cell leukemia, TTR gene	Stem Cell Exhaustion	A novel human leukaemic cell line, CTS, has a t(6;11) chromosomal translocation and characteristics of pluripotent stem cells.	8904886
Mixed phenotype acute leukemia, 11q23 Abnormality, TTR gene	Stem Cell Exhaustion	This CTS cell line may provide a useful tool in the study of the oncogenesis of mixed lineage leukaemia with 11q23 abnormalities and for the analysis of growth and differentiation of pluripotent stem cells.	8904886
Multiple Myeloma, Acute leukemia	Stem Cell Exhaustion	In a multivariate analysis the recovery of neutrophils was adversely associated with low numbers of nucleated cells infused (P < 0.13), bone marrow progenitor cell source, and diagnosis of multiple myeloma and acute leukemia (P < 0.001).	8905030
Neutropenia, Myelosuppression	Stem Cell Exhaustion	Administration of hematopoietic growth factors before high-dose chemotherapy (priming) may reduce myelosuppression directly, delaying the onset of neutropenia by expanding the mature neutrophil compartment, and shortening the duration of neutropenia by expanding progenitor cell mass.	8913281
Failure	Stem Cell Exhaustion	The failure of GM-CSF priming may be a result of its modest stimulation of hematopoiesis or the expansion of a committed progenitor cell population that is exquisitely sensitive to this regimen.	8913281
Stem Cell Factor, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We evaluated the effects of recombinant human flt3-L on proliferation, apoptosis, and Bcl-2 and Bax expression in primary AML cells and compared them with those of stem cell factor (SCF).	8916965
Lymphoma, Follicular, Failure, Toxic effect	Stem Cell Exhaustion	2-CDA is active in untreated follicular lymphomas, but time to treatment failure suggests no advantage compared with standard treatment and toxicity on haematopoietic stem cells appears to be more pronounced.	8922192
Acute Promyelocytic Leukemia	Stem Cell Exhaustion	Successful engraftment of sibling cord-blood stem cell transplantation in a child with acute promyelocytic leukemia.	8923791
Acute Promyelocytic Leukemia	Stem Cell Exhaustion	Cord blood stem cell transplantation (CBSCT) was performed on a patient with acute promyelocytic leukemia.	8923791
Mucoepidermoid Carcinoma, Thyroid Gland Mucoepidermoid Carcinoma, Carcinoma, Papillary, Thyroid carcinoma	Stem Cell Exhaustion	The diagnosis of this peculiar carcinoma of the thyroid exhibiting papillary and mucoepidermoid features together with undifferentiated (anaplastic) areas, reinforces the existence of a close relationship between papillary carcinoma and mucoepidermoid carcinoma, and supports the importance that ultimobranchial multipotential stem cells may have in the histogenesis of thyroid carcinomas.	8927569
Aplastic Anemia	Stem Cell Exhaustion	This study explores the hypothesis that acquired mutations of c-kit in the hematopoietic stem cell participate in the pathogenesis of aplastic anemia (AA).	8931956
Cytomegalovirus Infections	Stem Cell Exhaustion	Combined foscarnet -ganciclovir treatment for cytomegalovirus infections after allogeneic hemopoietic stem cell transplantation (Hsct).	8932810
Engraftment syndrome	Stem Cell Exhaustion	Clinical evidence for an engraftment syndrome associated with early and steep neutrophil recovery after autologous blood stem cell transplantation.	8932849
Specialty Type - cancer	Stem Cell Exhaustion	Seventy autologous peripheral blood stem cell transplants (APBSCT) performed in 61 cancer patients were retrospectively analyzed.	8932849
Hepatic necrosis	Stem Cell Exhaustion	We hypothesized that the HepPar1+ CK19+ progenitor cells are activated during human liver regeneration after massive hepatic necrosis and proliferate with the formation of so-called ductular hepatocytes or neocholangioles.	8941215
Hematologic Neoplasms	Stem Cell Exhaustion	Transplantation of allogeneic CD34+ peripheral blood stem cells in patients with advanced hematologic malignancy.	8943847
Hematologic Neoplasms	Stem Cell Exhaustion	Sixteen patients with advanced hematologic malignancies were transplanted with HLA-identical allogeneic peripheral blood stem cells (PBSCs) that were selected for CD34+ cells by an avidin-biotin immunoadsorption technique.	8943847
Specialty Type - cancer, Decreased platelet count	Stem Cell Exhaustion	Circulating thrombopoietin concentrations in thrombocytopenic patients, including cancer patients following chemotherapy, with or without peripheral blood progenitor cell transplantation.	8943898
Specialty Type - cancer	Stem Cell Exhaustion	In cancer patients receiving chemotherapy with (n = 12) or without (n = 6) peripheral blood progenitor cell transplantation, thrombopoietin concentrations varied inversely with platelet counts throughout the treatment period.	8943898
Disease, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Aplastic Anemia, Chronic myeloproliferative disorder	Stem Cell Exhaustion	Aplastic anemia, myelodysplastic syndromes (MDS) and chronic myeloproliferative diseases (MPD) are stem cell disorders.	8947580
Leptomeningeal Neoplasms	Stem Cell Exhaustion	The use of idarubicin during induction, the prognostic subclassification of patients, a careful control of dysmetabolic complications, the selection of the proper chemo-radioprevention for meningeal disease and perhaps the introduction of high-dose chemotherapy supported by autologous stem cell rescue appear to be the mainstay of further improvements.	8952158
Bone marrow hypocellularity	Stem Cell Exhaustion	Hematopoietic recovery after marrow failure was obtained following two consecutive courses of rh-G-CSF-mobilized peripheral blood stem cell infusions.	8952162
Primary graft failure	Stem Cell Exhaustion	Therefore we suggest that growth factor-stimulated peripheral blood should be considered as the first choice for allogeneic stem cells in order to avoid primary graft failure with donors over 50 years of age.	8952162
Graft failure	Stem Cell Exhaustion	No potential risk factors associated with graft failure, excluding recipient and donor age, were documented, whereas a relatively high number of progenitor cells were necessary to overcome the host-versus-graft barrier in our patient.	8952162
Multiple Myeloma	Stem Cell Exhaustion	High dose etoposide-based myeloablative therapy followed by autologous blood progenitor cell rescue in the treatment of multiple myeloma.	8952558
Multiple Myeloma	Stem Cell Exhaustion	A number of studies have demonstrated that high dose chemotherapy, with or without radiotherapy, with autologous marrow and/or peripheral blood progenitor cell support can result in improved overall and complete response rates in patients with multiple myeloma, and a minority of patients become long term survivors.	8952558
Hodgkin Disease, Lymphoma, Non-Hodgkin, Multiple Myeloma	Stem Cell Exhaustion	Based on their favorable experience with high dose etoposide-based regimens in patients with Hodgkin's disease and non-Hodgkin's lymphoma, the authors explored the use of these regimens prior to autologous progenitor cell rescue in patients with multiple myeloma.	8952558
Multiple Myeloma	Stem Cell Exhaustion	High dose etoposide-based myeloablative regimens followed by autologous blood progenitor cell rescue are relatively well tolerated and effective for the treatment of multiple myeloma, and a minority of patients become long term disease free survivors.	8952558
Malignant neoplasm of ovary	Stem Cell Exhaustion	A study of ovarian cancer patients treated with dose-intensive chemotherapy supported with peripheral blood progenitor cells mobilised by filgrastim and cyclophosphamide.	8956800
Malignant neoplasm of ovary	Stem Cell Exhaustion	We have shown that large numbers of haemopoietic progenitor cells are mobilised into the blood after filgrastim [granulocyte colony-stimulating factor (G-CSF)] alone and filgrastim following cyclophosphamide chemotherapy in previously untreated patients with ovarian cancer.	8956800
Malignant neoplasm of ovary	Stem Cell Exhaustion	We have also demonstrated that dose-intensive carboplatin and cyclophosphamide chemotherapy can be delivered safely to patients with ovarian cancer when supported by peripheral blood progenitor cells and filgrastim.	8956800
Chronic myeloproliferative disorder, Thrombocythemia, Essential	Stem Cell Exhaustion	Essential thrombocytosis (ET) is a clonal, chronic myeloproliferative disorder (MPD) originating from a multipotent stem cell.	8956864
Acute leukemia	Stem Cell Exhaustion	Cytogenetic and clinicobiological features of acute leukemia with stem cell phenotype: study of nine cases.	8956868
Malignant Neoplasms	Stem Cell Exhaustion	Predictive factors affecting mobilization and peripheral blood stem cell (PBSC) collection using single apheresis (SA) for rescuing patients after high-dose chemotherapy (HD.CHE) in various malignancies.	8971374
Hematologic Neoplasms, Neoplasms	Stem Cell Exhaustion	A consecutive series of 56 patients with hematologic malignancies and solid tumours had peripheral blood stem cells (PBSC) collected following mobilization with colony-stimulating factors (CSF) alone or after conventional chemotherapy (CHE) or high-dose cytoxan (HD.CY) followed by CSF.	8971374
Toxic effect	Stem Cell Exhaustion	We evaluated the efficacy, toxicity and feasibility of two cycles of high-dose chemotherapy (HDC), each supported with mobilized peripheral blood progenitor cells (PBPC).	8971377
Multiple Myeloma	Stem Cell Exhaustion	An economic evaluation of peripheral blood stem cell transplantation as an alternative to autologous bone marrow transplantation in multiple myeloma.	8971391
malignant disease	Stem Cell Exhaustion	Autologous peripheral blood stem cell transplantation (PBSCT) is increasingly being utilised as an alternative to autologous bone marrow transplantation (ABMT) in the treatment of malignant diseases.	8971391
Zygomycosis	Stem Cell Exhaustion	This is the first reported stem cell transplantation (SCT) in a patient with prior invasive mucormycosis.	8971393
Impaired T cell function	Stem Cell Exhaustion	Temporary corneal stem cell dysfunction after radiation therapy.	8976704
Impaired T cell function	Stem Cell Exhaustion	Corneal stem cell dysfunction is described, which recovered after the cessation of radiation.	8976704
Impaired T cell function	Stem Cell Exhaustion	Radiation therapy in this patient caused temporary stem cell dysfunction which resulted in conjunctivalisation in a part of the cornea.	8976704
Primary Myelofibrosis	Stem Cell Exhaustion	Differential expression of transforming growth factor-beta, basic fibroblast growth factor, and their receptors in CD34+ hematopoietic progenitor cells from patients with myelofibrosis and myeloid metaplasia.	8977245
Multiple Myeloma	Stem Cell Exhaustion	Allogeneic bone marrow transplantation versus autologous stem cell transplantation in multiple myeloma: a retrospective case-matched study from the European Group for Blood and Marrow Transplantation.	8977265
Multiple Myeloma	Stem Cell Exhaustion	A retrospective case-matched analysis was performed comparing 189 myeloma patients treated with allogeneic bone marrow transplantation (allo-BMT) with an equal number of patients who received autologous stem cell transplantation (ASCT).	8977265
Hair follicle structure	Stem Cell Exhaustion	In this study, we measured the levels of telomerase activity in dissected compartments of the human hair follicle: hair shaft, gland-containing fragment, upper intermediate fragment (where it is thought undifferentiated stem cells reside), lower intermediate fragment, and in the bulb-containing fragment (an area with high mitotic activity containing a more differentiated pool of keratinocytes).	8980299
Ocular surface disease	Stem Cell Exhaustion	First, to present a new classification of epithelial transplantation procedures for ocular surface disease; second, to present our experience with a keratolimbal allograft procedure for limbal stem cell deficiency; and third, to make recommendations for the indications and postoperative management of epithelial transplantation procedures.	8981714
Specialty Type - cancer	Stem Cell Exhaustion	Successful collection and transplantation of peripheral blood stem cells in cancer patients using large-volume leukaphereses.	8986864
leukemia	Stem Cell Exhaustion	Allogeneic transplantation for advanced leukemia: improved short-term outcome with blood stem cell grafts and tacrolimus.	8990368
Graft-vs-Host Disease	Stem Cell Exhaustion	We have evaluated the use of blood stem cell grafts for rapid hematopoietic recovery and tacrolimus (FK506) as GVHD prophylaxis to reduce early mortality after allogeneic transplantation.	8990368
leukemia	Stem Cell Exhaustion	These data suggest that the use of blood stem cell grafts and FK506 can reduce the early mortality after allogeneic transplantation for advanced leukemia.	8990368
Malignant Neoplasms	Stem Cell Exhaustion	Outpatient high-dose chemotherapy with autologous stem-cell rescue for hematologic and nonhematologic malignancies.	8996119
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	One explanation for this is that in older patients the acute myeloid leukaemia is more likely to have arisen from a pluripotent stem cell than from a lineage-restricted progenitor cell; the former has a high self-renewal capacity, an active drug-efflux pump, and high content of anti-apoptotic proteins, all of which contribute to chemoresistance.	8996433
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	[Cord blood stem cell transplantation for a patient with acute myelogenous leukemia (M1)].	8997124
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A five-year-old boy with acute myelogenous leukemia in relapse was treated by HLA-matched cord blood stem cell transplantation.	8997124
Peripheral Stem Cell Transplantation, Lymphoma, Non-Hodgkin, Leukemia, Myelocytic, Acute, Philadelphia chromosome positive chronic myelogenous leukemia	Stem Cell Exhaustion	Philadelphia chromosome-positive secondary acute myeloid leukemia following high-dose chemotherapy with peripheral blood progenitor cell support for relapsed low-grade non-Hodgkin's lymphoma.	9003159
Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Familial, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We report the case of a 47-year-old patient who developed acute myelogenous leukemia (AML) 18 months after receiving high-dose chemotherapy with peripheral blood progenitor cell support (PBPCT) for relapsed low-grade follicular non-Hodgkin's lymphoma (NHL).	9003159
Acute Undifferentiated Leukemia	Stem Cell Exhaustion	A child case of CD34+, CD33-, HLA-DR-, CD7+, CD56+ stem cell leukemia with thymic involvement.	9009257
Vena cava syndrome, Acute leukemia	Stem Cell Exhaustion	We report here a 7-year-old boy who developed stem cell acute leukemia with superior vena cava syndrome secondary to thymic involvement.	9009257
Acute Undifferentiated Leukemia	Stem Cell Exhaustion	Our results suggest that CD34+/HLA-DR-/CD7+/CD56+ stem cell leukemia may arise from transformation of a pluripotent precursor cell, which could differentiate to both myeloid and NK cell lineages.	9009257
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Peripheral blood stem cell transplantation for relapsed or refractory aggressive lymphoma in patients over 60 years of age.	9012928
Aggressive course	Stem Cell Exhaustion	We evaluated the feasibility of two cycles of salvage therapy followed by an autologous peripheral blood stem cell (PBSC) transplantation in 13 patients aged more than 60 years (median age: 62; range 61-72) suffering from relapsed (n = 10) or refractory (n = 3) aggressive NHL.	9012928
Tumor necrosis	Stem Cell Exhaustion	Interaction of 2-chlorodeoxyadenosine in combination either with interferons or recombinant human tumor necrosis factor alpha on myeloid progenitor cells in vitro.	9017167
Tumor necrosis, Leukemia, Myelocytic, Acute, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The objective of the present study was to investigate the interactions of 2-chlorodeoxyadenosine (2-CdA) with interferon alpha or gamma (IFN-alpha, IFN-gamma), as well as between 2-CdA and recombinant human tumor necrosis factor alpha (rhTNF-alpha), on the clonal growth of granulocyte-macrophage progenitor cells (CFU-GM) from patients with chronic myeloid leukemia (CML) and on clonogenic leukemia blasts (CFU-L) from acute myeloid leukemia (AML) patients.	9017167
Acute Undifferentiated Leukemia	Stem Cell Exhaustion	A diagnosis of stem cell leukemia was made.	9028157
Myeloid Leukemia, leukemia, Acute Undifferentiated Leukemia	Stem Cell Exhaustion	The leukemia was transformed to minimally differentiated myeloid leukemia from stem cell leukemia.	9028157
Fanconi Anemia	Stem Cell Exhaustion	Unrelated peripheral blood stem cell transplantation for Fanconi anemia.	9028563
Leukemia, Myelocytic, Acute, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Perturbation in the ability of bone marrow stroma from patients with acute myeloid leukemia but not chronic myeloid leukemia to support normal early hematopoietic progenitor cells.	9029183
Myeloid Leukemia	Stem Cell Exhaustion	Suppression of in vitro maintenance of non-promyelocytic myeloid leukemia clonogenic cells by all-trans retinoic acid: modulating effects of dihydroxylated vitamin D3, alpha interferon and 'stem cell factor'.	9029186
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	To identify the highest possible dose of cyclophosphamide (C) and etoposide (E) to be given with high-dose doxorubicin (D) and filgrastim (G-CSF) but without stem cell support in high-risk non-Hodgkin's lymphoma.	9037362
Toxic effect	Stem Cell Exhaustion	The toxicity was similar to that of standard autologous stem cell transplantation programs.	9037362
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Although the observed increases in growth rates of histologically normal brain cultures do not correlate with in vivo behavior, these findings corroborate the previously reported stem cell potential of invasive glioma cells.	9046311
Lymphoma, Multiple Myeloma, leukemia	Stem Cell Exhaustion	Outcome for patients with leukemia, multiple myeloma and lymphoma who relapse after high dose therapy and autologous stem cell support.	9049964
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Complete remission following donor PBSC after low-dose cytarabine chemotherapy for early relapse of acute myelogenous leukemia after allogeneic stem cell transplantation.	9051249
Lymphoproliferative Disorders	Stem Cell Exhaustion	Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit.	9053465
filgrastim	Stem Cell Exhaustion	To assess the clinical and economic benefit of low-dose (50 microg/m2) filgrastim after peripheral blood stem-cell transplantation (PBSCT) in a randomized, placebo-controlled double-blinded study.	9053465
Lymphoproliferative Disorders	Stem Cell Exhaustion	Thirty-eight patients with lymphoproliferative disorders were randomized to receive low-dose filgrastim (19 patients) or placebo (19 patients) beginning on the first day after stem-cell reinfusion and continuing until absolute neutrophil count (ANC) was greater than 0.5 x 10(9)/L.	9053465
Hodgkin Disease, Lymphoma, Non-Hodgkin, Lymphoma, Non-Hodgkin, Familial, HD Term Type, Childhood Breast Carcinoma, Neoplasms	Stem Cell Exhaustion	We analyzed the safety and effectiveness of high-dose etoposide (2 g/m2) followed by granulocyte colony-stimulating factor (G-CSF) as a peripheral-blood progenitor cell (PBPC) mobilization regimen and assessed extent of tumor reduction in patients with breast cancer, non-Hodgkin's lymphoma (NHL), and Hodgkin's disease (HD).	9053502
Hodgkin Disease, Lymphoma, Non-Hodgkin, Childhood Breast Carcinoma	Stem Cell Exhaustion	Mobilization of peripheral-blood progenitor cells with high-dose etoposide and granulocyte colony-stimulating factor in patients with breast cancer, non-Hodgkin's lymphoma, and Hodgkin's disease.	9053502
Lecithin Acyltransferase Deficiency	Stem Cell Exhaustion	We have established a mouse model for human LCAT deficiency by performing targeted disruption of the LCAT gene in mouse embryonic stem cells.	9054454
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Long-term haematological reconstitution following BEAM and autologous transplantation of circulating progenitor cells in non-Hodgkin's lymphoma.	9054673
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	We report on long-term haematological recovery and clinical outcome after high-dose chemotherapy supported by circulating progenitor cells (CPC) transplantation in non-Hodgkin's lymphoma (NHL) patients, and analyse the role of variables which might influence engraftment.	9054673
Choriocarcinoma	Stem Cell Exhaustion	Combination of high-dose chemotherapy, autologous bone marrow/peripheral blood stem cell transplantation, and thoracoscopic surgery in refractory nongestational choriocarcinoma of a 45XO/46XY female: a case report.	9062164
Histogenic Process	Stem Cell Exhaustion	So the authors favor the histogenesis from a pluripotent endocervical stem cell.	9065588
Stem Cell Factor, Tumor necrosis, beta Thalassemia	Stem Cell Exhaustion	The unstimulated and induced production of granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), IL-3, IL-6, stem cell factor (SCF), IL-1beta, tumour necrosis factor-alpha (TNF-alpha), TNF-beta, interferon-gamma (IFN-gamma) and transforming growth factor-beta (TGF-beta) was determined after culture of blood mononuclear cells from 22 patients with severe beta-thalassaemia in a regular transfusion programme, five non-regularly transfused patients with beta-thalassaemia intermedia and nine normal persons.	9067538
Malaria, Falciparum	Stem Cell Exhaustion	Levels of stem cell factor and interleukin-3 in serum in acute Plasmodium falciparum malaria.	9067661
Malaria, Falciparum, Stem Cell Factor	Stem Cell Exhaustion	The purpose of the present study was to measure serum concentrations of stem cell factor (SCF) and interleukin-3 (IL-3) in patients with acute Plasmodium falciparum malaria.	9067661
Multiple Organ Failure	Stem Cell Exhaustion	A second transplantation, using mobilized peripheral blood stem cells from the same donor, was tried but the patient died of progressive multiple organ failure before any evidence of engraftment.	9071840
Malignant neoplasm of ovary, Lymphoma, leukemia	Stem Cell Exhaustion	The plasma concentrations of erythropoietin (Ep), soluble transferrin receptors (sTfRs), iron, total iron binding capacity (TIBC) and ferritin were monitored in five leukaemia patients undergoing autologous bone marrow stem cell transplantation (BMSCT) and in 10 lymphoma and 21 ovarian cancer patients undergoing autologous peripheral blood SCT (PBSCT); 9/21 ovarian cancer patients received recombinant human G-CSF and Ep and six recombinant human GM-CSF and Ep following SCT.	9074420
Condylomata Acuminata	Stem Cell Exhaustion	Severe anal condylomata acuminata following high-dose chemotherapy and autologous hematopoietic stem cell transplantation: a case report.	9085629
Lymphoma, Follicular, Condylomata Acuminata	Stem Cell Exhaustion	We report the case of a 37 years old male patient who developed severe anal condylomata acuminata after high-dose chemotherapy and autologous hematopoietic stem cell transplantation for follicular non-Hodgkin's lymphoma.	9085629
Anal Condyloma Acuminatum	Stem Cell Exhaustion	The role of cellular immunodeficiency observed after high-dose chemotherapy and autologous hematopoietic stem cell transplantation as etiology of anal condylomata is discussed.	9085629
Histiocytic Disorders, Malignant	Stem Cell Exhaustion	We infused peripheral blood stem cells (PBSC) into 51 patients with various malignant disorders, after myeloablative conditioning.	9085735
Damage, Infiltration	Stem Cell Exhaustion	We conclude that marrow damage resulting from a combination of neoplastic infiltration, chemotherapy and TBI may result not only in low PBSC yields but also in an impaired capacity of the marrow microenvironment to support transplanted stem cells.	9085735
Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	Prolonged resolution of hemophagocytic lymphohistiocytosis following myeloablative chemotherapy and subsequent autologous peripheral blood stem cell transplantation.	9085745
Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	A 30-month-old boy with hemophagocytic lymphohistiocytosis (HLH) received an autologous peripheral blood stem cell transplant (PBSCT) following high-dose chemotherapy.	9085745
Neoplasms	Stem Cell Exhaustion	In three cases DNA-aneuploid stem cell lines were found only among the 4-part sections and were not detected when the whole tumor section was analysed.	9090959
Small cell carcinoma of lung	Stem Cell Exhaustion	Thirty patients (19 with LD, and 11 with ED SCLC) proceeded to VIC-E high-dose chemotherapy with autologous peripheral blood stem cell transplantation (PBSCT) at a cumulative dose of etoposide 1500 mg/m2, ifosfamide 12,000 mg/m2, carboplatin 750 mg/m2 and epirubicin 150 mg/m2 (VIC-E).	9093707
Corneal Diseases	Stem Cell Exhaustion	Cytologic evidence of corneal diseases with limbal stem cell deficiency.	9097795
Corneal Diseases, Keratitis	Stem Cell Exhaustion	To determine which human corneal diseases show similar abnormal corneal surfaces, characterized by conjunctival epithelial ingrowth (conjunctivalization), vascularization, and chronic keratitis (i.e., a constellation of signs termed limbal stem cell dysfunction [deficiency], which have been noted in experimental rabbit models).	9097795
Microorganism, Burn injury, Stevens-Johnson Syndrome	Stem Cell Exhaustion	Category 1 comprised 53 patients with a clear history showing limbal stem cell destruction by chemical/thermal burns, Stevens-Johnson syndrome, multiple surgeries and cryotherapies, contact lens wear, and severe microbial keratitis.	9097795
Keratopathy, Limbitis, Multiple Sulfatase Deficiency Disease, Stem cells, Aniridia, Idiopathic Neuropathy	Stem Cell Exhaustion	Patients in category 2 (n = 41), did not have such a history, but gradual loss of stem cell functions over time was disclosed and included diverse causes such as aniridia, multiple endocrine deficiencies, neurotrophic keratopathy, peripheral inflammatory keratopathy or limbitis, and idiopathy.	9097795
Aplastic Anemia	Stem Cell Exhaustion	To describe the suppressive effect of sera from patients with aplastic anemia (AA) on heamatopoietic progenitor cells and explore further the features of serum inhibitor, we first examined the inhibiting activity of the serum on the colony formation of burst-forming units of erythrocyte (BFU-E) and colony-forming units of granulocyte/macrophage (CFU-GM).	9100458
cell transformation	Stem Cell Exhaustion	It is expected that the mathematical methods developed here will also be useful for more general (N-stage) models of malignant transformation of stem cell populations undergoing growth or decline.	9111777
Leukemogenesis	Stem Cell Exhaustion	Leukemogenesis is modeled as transformation of target stem cells that initially grow rapidly in the embryo but plateau and then decline in postnatal childhood.	9111777
Aplastic Anemia, Primary graft failure	Stem Cell Exhaustion	Successful engraftment after primary graft failure in aplastic anemia using G-CSF mobilized peripheral stem cell transfusions.	9116616
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	These findings suggest that normal TRFs in a small number of CML patients at the time of diagnosis may have a significant amount of normal stem cells remaining.	9118038
Neutropenia, Toxic effect, Decreased platelet count	Stem Cell Exhaustion	These data indicate that dose-intensified chemotherapy may be delivered without bone marrow or peripheral stem cell support, with acceptable toxicity, and that, while G-CSF alone shortens days of neutropenia, the combination of the two cytokines shortens the time of thrombocytopenia and decreases the number of PLT transfusions.	9124202
Leukemia, Myelocytic, Acute, Lymphoid leukemia, Acute leukemia	Stem Cell Exhaustion	The t(4;12) abnormality is associated with unique characteristics of acute leukemia namely stem cell or secondary AML in adults, and B lymphoid leukemia in children.	9130613
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Haploidentical related umbilical cord blood stem cell transplant in a child with acute non-lymphocytic leukemia.	9134166
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Umbilical cord blood stem cells (UCBSC) were used to reconstitute hematopoiesis following myeloablative therapy in a 13-month-old infant with acute nonlymphocytic leukemia (ANLL):FAB-M5 who had failed to sustain a chemotherapeutic remission.	9134166
Megakaryocytopoiesis	Stem Cell Exhaustion	To elucidate the role of TPO in the reconstitution of megakaryopoiesis and platelet production after stem cell transplantation, we measured serum TPO levels in nine patients undergoing autologous peripheral blood stem cell transplantation (PBSCT) and in healthy volunteers.	9134167
Multiple Myeloma	Stem Cell Exhaustion	One patient with multiple myeloma received purified CD34+ peripheral blood stem cells.	9134167
Lymphoma	Stem Cell Exhaustion	Twenty patients with relapsed or refractory lymphoma were treated with busulfan (16 mg/kg) and cyclophosphamide (120 mg/kg) (BU/CY) followed by peripheral blood stem cell rescue in 19 patients or autologous bone marrow in one patient.	9134168
peripheral blood	Stem Cell Exhaustion	Peripheral blood myeloma plasma cells had the same composite phenotype, but expressed significantly lower levels of CD56 and Syndecan-1, and were detected in 75% (38/51) of patients at presentation, 92% (11/12) of patients in relapse, and 40% (4/10) of stem cell harvests.	9136941
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myeloid leukaemia (CML) is believed to represent a stem cell disorder involving all three cell lineages.	9136947
Malignant Glioma	Stem Cell Exhaustion	To determine: (1) the maximum tolerable dose (MTD) of thiotepa (TT) that can be administered with etoposide without stem cell support; (2) whether this regimen is active against recurrent malignant gliomas.	9137533
Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	High-dose therapy with peripheral blood progenitor cell transplantation in multiple myeloma.	9137792
Neoplasms, Granulocytic Sarcoma	Stem Cell Exhaustion	By definition, the extramedullary tumor could not be diagnosed as a granulocytic sarcoma or (differentiated) mastocytoma, but the possibility that a mast cell progenitor could be involved in the evolution of both tumors cannot be ruled out.	9140315
Acute Promyelocytic Leukemia	Stem Cell Exhaustion	The in vitro effects of all-trans-retinoic acid and hematopoietic growth factors on the clonal growth and self-renewal of blast stem cells in acute promyelocytic leukemia.	9150345
ATRICHIA WITH PAPULAR LESIONS	Stem Cell Exhaustion	We investigated the effects of ATRA and three myeloid growth factors, including G-CSF, on the growth of the leukemic stem cells of 10 APL patients.	9150345
Malignant neoplasm of urinary bladder, Osteitis Deformans	Stem Cell Exhaustion	CEA and cyokeratin staining demonstrated identical expression pattern in bladder cancer cells and Paget's cells, which suggested both neoplastic cells originated from one progenitor cell.	9155118
Anaplastic Lymphoma Post-Transplant Lymphoproliferative Disorder, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Allogeneic peripheral blood stem cell transplant for myelodysplasia after chemotherapy for post-transplant lymphoma in a cardiac transplant recipient at 10 years.	9156271
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	A 32-year-old male received an allogeneic peripheral blood stem cell transplant (alloPBSCT) for myelodysplasia from his one HLA-A antigen mismatched brother.	9156271
Specialty Type - cancer	Stem Cell Exhaustion	The mitotic rate of stem cells is a major determinant of cancer risk.	9160283
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Intensive sequential chemotherapy with repeated blood stem-cell support for untreated poor-prognosis non-Hodgkin's lymphoma.	9164178
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	To demonstrate the feasibility and efficacy of six ambulatory high-dose sequential chemotherapy courses that include three intensified cycles supported by stem-cell infusion in high-risk and high-intermediate-risk untreated non-Hodgkin's lymphoma (NHL) patients.	9164178
Childhood Breast Carcinoma	Stem Cell Exhaustion	High-dose chemotherapy with autologous hematopoietic stem-cell support for breast cancer in North America.	9164197
Childhood Breast Carcinoma	Stem Cell Exhaustion	To identify trends in high-dose therapy with autologous hematopoietic stem-cell support (autotransplants) for breast cancer (1989 to 1995).	9164197
PAFAH1B1 wt Allele	Stem Cell Exhaustion	The present data and results from a few other MDS-derived cell lines suggest that the transforming event in MDS seems to occur in an immature pluripotent progenitor cell.	9168445
Lymphoma, Hemolytic-Uremic Syndrome	Stem Cell Exhaustion	Hemolytic uremic syndrome following autologous peripheral blood stem cell transplantation in a patient with malignant lymphoma.	9169652
Hemolytic-Uremic Syndrome	Stem Cell Exhaustion	However, only a few cases of HUS following autologous peripheral blood stem cell transplantation (PBSCT) have been reported.	9169652
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	on day +22 after allogeneic peripheral blood stem cell transplantation for CML.	9169653
Multiple Myeloma	Stem Cell Exhaustion	The significance of light chain-restricted bone marrow plasma cells after peripheral blood stem cell transplantation for multiple myeloma.	9169660
Plasmacytosis	Stem Cell Exhaustion	We attempted to retrospectively determine, by morphologic assessment of plasma cell percentage, immunohistologic assessment of plasma cell light chain ratio (LCR), and correlation with clinical outcome, the prevalence and significance of plasmacytosis in the posttransplantation bone marrow biopsy specimens of 25 patients with MM who underwent autologous peripheral blood stem cell transplantation (PBSCT).	9169660
Multiple Myeloma	Stem Cell Exhaustion	Comparison of interferon tolerance after autologous bone marrow or peripheral blood stem cell transplants for myeloma patients who have responded to induction therapy.	9172806
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Mobilization of peripheral blood progenitor cells following CHOP treatment combined with delayed granulocyte colony-stimulating factor administration in patients with non-Hodgkin's lymphoma.	9172813
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin, Bone Marrow	Stem Cell Exhaustion	The kinetic change in peripheral blood progenitor cells (PBPC) during 3 to 6 cycles of standard CHOP regimen supported with human recombinant granulocyte colony-stimulating factor (rG-CSF) was investigated in three patients with newly diagnosed intermediate grade, diffuse large cell type, non-Hodgkin's lymphoma (NHL) without bone marrow invasion.	9172813
Malignant Neoplasms	Stem Cell Exhaustion	So far, the discussion concerning the pathogenesis of the simultaneous occurrence of these two malignancies has been speculative, opposing the theory of two separate malignant clones to the theory of a common stem cell malignancy.	9174549
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Apoptosis of hematopoietic progenitor cells is increased in myelodysplastic syndromes (MDS).	9177438
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In this article we present results from cytogenetic examinations of FACS-isolated stem cell subpopulations in eight patients (four AML and four MDS).	9180291
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	CD34+/CD117+/- stem cell subpopulations were examined in two patients with AML and three patients with MDS.	9180291
S100A4 protein, human	Stem Cell Exhaustion	Recent data of our group and others provide evidence that in AML malignant transformation may regularly occur at the level of stem cells.	9180291
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We conclude that in AML and MDS stem cells are the target of leukemogenic genetic defects.	9180291
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	These findings may be related to changing the natural course of CML, to therapy, or to the emergence of suppressed clones in a stem cell disorder.	9180306
Multiple Myeloma	Stem Cell Exhaustion	Sixty-three new untreated patients with multiple myeloma under the age of 70 years received C-VAMP induction treatment followed by high-dose intravenous melphalan (200 mg m(-2)) and autologous stem cell transplant, either with marrow [autologous bone marrow transplants (ABMT), n = 26] or with granulocyte colony-stimulating factor (G-CSF)-mobilized stem cells from the blood [peripheral blood stem cell transplants (PBSCT), n = 37].	9184187
Multiple Myeloma	Stem Cell Exhaustion	Comparison of marrow vs blood-derived stem cells for autografting in previously untreated multiple myeloma.	9184187
Peripheral Blood Stem Cells, Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Stem Cell Exhaustion	Treatment of mantle-cell lymphomas with the VAD +/- chlorambucil regimen with or without subsequent high-dose therapy and peripheral blood stem-cell transplantation.	9187441
Toxic effect	Stem Cell Exhaustion	Because of its low toxicity for haematopoetic stem-cells this form of chemotherapy is often undertaken before high-dose blood stem-cell transplantation.	9190299
S100A4 protein, human	Stem Cell Exhaustion	These results suggest that the malignant transformation in B-CLL may involve early hematopoietic stem cells and place a note of caution on future strategies using autologous stem cell transplantation.	9192749
Cessation of life, Multiple Organ Failure	Stem Cell Exhaustion	Treatment was generally well tolerated, with only 1 death from multiorgan failure before receiving stem cells.	9192777
Graft vs Leukemia Effect	Stem Cell Exhaustion	The immune-mediated graft-versus-leukemia effect is important to prevent relapse after allogeneic progenitor cell transplantation.	9192777
Childhood Breast Carcinoma	Stem Cell Exhaustion	Erythroid burst-forming units (BFU-E) predict hematopoietic recovery after peripheral blood progenitor cell transplantation in patients with advanced breast cancer.	9193751
Childhood Breast Carcinoma	Stem Cell Exhaustion	In 29 consecutive heavily pretreated stage IV breast cancer patients, we analyzed patient factors and in vitro characteristics of peripheral blood progenitor cell (PBPC) collections that might correlate with the speed of hematopoietic recovery after autologous transplantation.	9193751
Hemolysis (biological function)	Stem Cell Exhaustion	Early and fatal immune haemolysis after so-called 'minor' ABO-incompatible peripheral blood stem cell allotransplantation.	9193761
Acute Undifferentiated Leukemia	Stem Cell Exhaustion	Differential chemosensitivity of leukemic cells in the myeloid and lymphoid phases of stem cell leukemia (a case report).	9201294
Childhood Breast Carcinoma	Stem Cell Exhaustion	High-dose busulfan, melphalan, thiotepa and peripheral blood stem cell infusion for the treatment of metastatic breast cancer.	9208111
Childhood Breast Carcinoma	Stem Cell Exhaustion	The purpose of this study was to determine the outcome of patients with metastatic breast cancer treated with high-dose busulfan (Bu), melphalan (Mel) and thiotepa (TT) followed by peripheral blood stem cell (PBSC) infusion.	9208111
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	t(3;21) following peripheral blood stem cell transplantation in chronic phase chronic myeloid leukaemia.	9208122
Hematopoietic Neoplasms, Chromosome Aberrations	Stem Cell Exhaustion	Chromosomal abnormality inv(3)(q21q26) associated with multilineage hematopoietic progenitor cells in hematopoietic malignancies.	9209472
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Detection of trisomy 12 in CD34+ progenitor cells in a patient with B-cell chronic lymphocytic leukemia by fluorescence in situ hybridization.	9209642
Mantle cell lymphoma	Stem Cell Exhaustion	Sequential high-dose therapy and autologous stem cell transplantation for treatment of mantle cell lymphoma.	9209672
Neoplasms	Stem Cell Exhaustion	All patients underwent one to two cycles of Dexa-BEAM chemotherapy to reduce the tumor load and to mobilize peripheral blood progenitor cells (PBPC).	9209672
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	On the subject of acute myeloid leukemia (AML), there is little consensus about the target cell within the hematopoietic stem cell hierarchy that is susceptible to leukemic transformation, or about the mechanism that underlies the phenotypic, genotypic and clinical heterogeneity.	9212098
Leukemia, Myelocytic, Acute, diabetic, Immunologic Deficiency Syndromes	Stem Cell Exhaustion	Here we demonstrate that the cell capable of initiating human AML in non-obese diabetic mice with severe combined immunodeficiency disease (NOD/SCID mice) - termed the SCID leukemia-initiating cell, or SL-IC - possesses the differentiative and proliferative capacities and the potential for self-renewal expected of a leukemic stem cell.	9212098
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The SL-ICs from all subtypes of AML analyzed, regardless of the heterogeneity in maturation characteristics of the leukemic blasts, were exclusively CD34++ CD38-, similar to the cell-surface phenotype of normal SCID-repopulating cells, suggesting that normal primitive cells, rather than committed progenitor cells, are the target for leukemic transformation.	9212098
Toxic effect	Stem Cell Exhaustion	This study was designed to evaluate the efficacy and toxicity of the docetaxel/doxorubicin/cyclophosphamide combination both alone and as induction before high-dose chemotherapy, supplemented by autologous peripheral blood stem-cell transplantation.	9213324
Stem Cell Factor	Stem Cell Exhaustion	In methylcellulose cultures, flt3L stimulated formation of hematopoietic colonies only weakly, whereas it had an additive effect when combined with erythropoietin (Epo), stem cell factor (SCF), interleukin-3 (IL-3), interleukin-11 (IL-11), or granulocyte colony-stimulating factor (G-CSF).	9216732
Myeloproliferative disease, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	In patients with myeloproliferative disorders and myelodysplastic syndromes the demonstration of skewed X inactivation patterns in multiple haemopoietic lineages has been taken to indicate a stem cell origin for these groups of diseases.	9217198
BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 20	Stem Cell Exhaustion	Impact of obesity on allogeneic stem cell transplant patients: a matched case-controlled study.	9217595
BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 20, Malignant Neoplasms, Metabolic Diseases	Stem Cell Exhaustion	To determine the impact of obesity on survival after high-dose therapy followed by allogeneic stem cell transplant in adults and children with various malignancies as well as metabolic disorders.	9217595
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The expression of Thy-1 on leukemia cells from patients with AML may need to be considered in the development of methods of normal stem cell isolation from these patients.	9225063
Lymphoma	Stem Cell Exhaustion	Multiple cycles of aggressive chemotherapy prior to autologous peripheral stem cell transplantation for lymphoma.	9227818
Lymphoma	Stem Cell Exhaustion	To assess the efficacy and tolerability of this regimen alone and in combination with autologous stem cell transplantation (ASCT) in patients with relapsed or refractory lymphoma.	9227818
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Data from 225 multiple myeloma (MM) patients, undergoing peripheral stem cell (PBSC) mobilization with high-dose cyclophosphamide and hematopoietic growth factors, were analyzed for median CD34+ cell count and median time to post-transplant neutrophil (ANC > 500/microliters) and platelet (> 50,000/microliters) recovery according to age groups (20-49, 50-59 and > or = 60 years) and duration of prior therapy (< or = 12, 13-24, or > 24 months).	9232248
Kidney Failure, Chronic, Multiple Myeloma	Stem Cell Exhaustion	Peripheral blood stem cell transplantation in a multiple myeloma patient with end-stage renal failure.	9232259
Lymphoma	Stem Cell Exhaustion	Stem cell mobilization in resistant or relapsed lymphoma: superior yield of progenitor cells following a salvage regimen comprising ifosphamide, etoposide and epirubicin compared to intermediate-dose cyclophosphamide.	9233591
Lymphoma	Stem Cell Exhaustion	We analysed the factors influencing the efficacy of peripheral blood stem cell (PBSC) collection in patients with lymphoma.	9233591
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Several experimental and clinical findings support a role for autologous stem cell transplantation (ASCT) in CML.	9234574
Multiple Myeloma	Stem Cell Exhaustion	Eighteen extensively pre-treated patients (35-73 years, median 46) with relapsed multiple myeloma received salvage chemotherapy with 6 g/m2 cyclophosphamide, 800 mg/m2 carboplatin, and 1800 mg/m2 etoposide (CCV) as a 96-h continuous infusion followed by autologous peripheral blood stem cells.	9244413
Pneumonia	Stem Cell Exhaustion	BK papova virus pneumonia following hematopoietic stem cell transplantation.	9244421
Panniculitis	Stem Cell Exhaustion	Effective high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation in a patient with the aggressive form of cytophagic histiocytic panniculitis.	9244423
Neoplasms	Stem Cell Exhaustion	Metastatic primitive neuroectodermal tumour of the ovary: successful treatment with mega-dose chemotherapy followed by peripheral blood progenitor cell rescue.	9251739
Ovarian	Stem Cell Exhaustion	Mega-dose chemotherapy followed by progenitor cell rescue may provide optimal therapy for patients presenting with metastatic ovarian PNET.	9251739
Glycophorin A	Stem Cell Exhaustion	Assays of glycophorin-A (GPA) mutations in red blood cells were also performed to obtain a relative measurement of damage sustained by the erythroid stem cell population.	9254732
Childhood Breast Carcinoma	Stem Cell Exhaustion	Should soybean agglutinin purging be performed in breast cancer patients undergoing autologous stem cell transplantation?	9256903
Childhood Breast Carcinoma	Stem Cell Exhaustion	High-dose chemotherapy (HDC) followed by autologous stem cell transplantation (ASCT) has gained an increasing role in the treatment of high-risk Stage II-III and/or metastatic breast cancer patients.	9256903
Neoplasms	Stem Cell Exhaustion	Several investigators reported on a high rate of tumor cells contaminating the bone marrow and peripheral blood stem cell collection.	9256903
Neoplasms	Stem Cell Exhaustion	Nevertheless, the clinical implication of reinfusion of tumor cells with the stem cells to the relapse rate is still uncertain.	9256903
Secondary malignant neoplasm of lung	Stem Cell Exhaustion	We present a case in which a 50-year-old patient relapsed with multiple pulmonary metastases shortly after peripheral blood stem cell transplantation.	9257895
Neoplasms	Stem Cell Exhaustion	This may provide valuable insights into tumour cell biology and mechanisms by which stem cell mobilisation may alter this.	9257895
Stem Cell Factor	Stem Cell Exhaustion	Cells were cultured with TPO alone or combined with rh interleukin-3 (IL-3) or stem cell factor (SCF).	9260579
Rheumatoid Arthritis	Stem Cell Exhaustion	Based on the size of the colonies they formed, the macrophage colony forming cells detected in patients with RA probably corresponded to primitive hematopoietic progenitor cells, defined as high proliferative potential colony forming cells (HPP-CFC).	9263144
PAFAH1B1 wt Allele, Hematological Disease, Aplastic Anemia, Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Paroxysmal nocturnal haemoglobinuria (PNH), aplastic anaemia (AA) and myelodysplastic syndrome (MDS) are haemopoietic stem cell disorders.	9266937
Hematological Disease	Stem Cell Exhaustion	These results suggest that not only PIG-A, but also other genes including the GPA gene, are hypermutable in haemopoietic stem cell disorders, and that mutagenic pressure and/or gene instability can contribute to the pathogenesis of these disorders.	9266937
Refractory anemia with ringed sideroblasts, Myeloid-Lymphoid Leukemia Protein	Stem Cell Exhaustion	It may be hypothesized that an initial event which selects a clone of stem cells that retains the capacity to differentiate into myeloid and lymphoid line would manifest with the features of RARS in the myeloid line and with the sort of immunological abnormalities reported in this case.	9267163
Hereditary Breast and Ovarian Cancer Syndrome	Stem Cell Exhaustion	Collection of peripheral blood stem cells following administration of paclitaxel, cyclophosphamide, and filgrastim in patients with breast and ovarian cancer.	9267668
Hereditary Breast and Ovarian Cancer Syndrome, Toxic effect	Stem Cell Exhaustion	To determine the toxicities and efficacy of paclitaxel, cyclophosphamide (Cy), and recombinant human granulocyte-colony stimulating factor (filgrastim) administered for mobilization and collection of peripheral blood stem cells (PBSC) in patients with breast and ovarian cancer.	9267668
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myeloid leukemia is a clonal stem cell disorder associated with the Philadelphia (Ph) translocation [t(9;22) (q34;q11)].	9269756
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	AML with t(8;21) has a distinctive immunophenotype, characterized by expression of the myeloid and stem cell antigens CD13, CD15, CD34, and HLADr, and frequent expression of the B-cell antigen CD19 and the neural cell adhesion molecule CD56, a natural killer cell/stem cell antigen.	9269784
Childhood Breast Carcinoma	Stem Cell Exhaustion	High-dose chemotherapy with autologous hematopoietic stem-cell transplantation in breast cancer.	9272142
Childhood Breast Carcinoma	Stem Cell Exhaustion	Since 1981 we have conducted four studies of the treatment of metastatic and postoperative high-risk breast cancer with high-dose chemotherapy supported by autologous hematopoietic stem-cell transplantation (AHSCT).	9272142
Bone Marrow Suppression	Stem Cell Exhaustion	Peripheral blood stem-cell transplantation shortened the duration of bone marrow suppression more effectively than did bone marrow transplantation, thereby optimizing high-dose chemotherapy.	9272142
Rheumatoid Arthritis	Stem Cell Exhaustion	The current studies examined the influences of gold sodium thiomalate (GST) and bucillamine (BUC), two potent disease-modifying antirheumatic drugs (DMARDs), on the capacity of bone marrow progenitor cells to generate CD14(+) cells in patients with RA, in order to delineate their mechanisms of action.	9281388
leukemia	Stem Cell Exhaustion	These results suggest that: 1) in AML-TMDS patients, leukemia transformation occurs in a more undifferentiated pluripotent stem cell, leading to a dysplastic residual hemopoiesis besides the blast proliferation; 2) the incidence of TMDS in our group of patients did not influence the clinical outcome after treatment of the disease.	9283908
Childhood Breast Carcinoma	Stem Cell Exhaustion	Thirty breast cancer patients received injections of peripheral blood stem cells after the same high-dose chemotherapy.	9287240
Hyperparathyroidism, Primary	Stem Cell Exhaustion	Effect of successful parathyroidectomy on hematopoietic progenitor cells and parameters of red blood cells in patients with primary hyperparathyroidism.	9288576
Hyperparathyroidism	Stem Cell Exhaustion	Elevated levels of parathyroid hormone (PTH) in primary and secondary hyperparathyroidism inhibit hematopoiesis at the level of hematopoietic progenitor cells, mainly the burst forming units-erythroid (BFUe).	9288576
Parathyroid Adenoma	Stem Cell Exhaustion	Removal of parathyroid adenomas is associated with an increase in hematopoietic progenitor cells.	9288576
Hyperparathyroidism, Primary	Stem Cell Exhaustion	We examined the effect of parathyroidectomy (PTX) in 10 patients with histologically proven primary hyperparathyroidism on hematopoietic progenitor cells and several parameters of red blood cells before and at 5, 30 and 90 days after PTX.	9288576
Inflammation, Mastocytosis, Squamous metaplasia	Stem Cell Exhaustion	We propose that respiratory epithelium is the "native" epithelium of LNC and squamous metaplasia results from inflammation induced stem cell hyperplasia in respiratory epithelium, evidenced by co-expression of "simple" and "stratified-epithelial-type" CK in all cells of transitional-type pseudostratified epithelium, the early stage in metaplastic transformation.	9298101
Anemia	Stem Cell Exhaustion	Parvovirus B19 has a marked tropism for erythroid progenitor cells and this may lead to chronic anemia in predisposed individuals.	9299850
Hepatitis B	Stem Cell Exhaustion	Persistence of hepatic hepatitis B virus after serological clearance of HBsAg with autologous peripheral stem cell transplantation.	9301561
Hepatitis B	Stem Cell Exhaustion	Delayed clearance of hepatitis B surface antigen was previously reported in a 38 year old woman after high dose chemotherapy with autologous peripheral blood stem cell rescue.	9301561
Multiple Myeloma	Stem Cell Exhaustion	Peripheral blood progenitor cell transplantation in multiple myeloma following high-dose melphalan-based therapy.	9304704
Toxic effect, Multiple Myeloma	Stem Cell Exhaustion	The objective of our study was to evaluate the efficacy and toxicity of a high-dose melphalan-based therapy with or without total body irradiation (TBI) followed by peripheral blood progenitor cell (PBPC) transplantation in patients with multiple myeloma.	9304704
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	The present study revealed the duplication at the juxtamembrane and the first tyrosine kinase domains of FLT3 in seven of 92 (8%) patients with myelodysplastic syndrome (MDS) and AML with trilineage myelodysplasia (AML/TMDS), the diseases which may represent neoplastic changes of pluripotent stem cells.	9305595
leukemia	Stem Cell Exhaustion	FLT3 is a member of receptor tyrosine kinases expressed in leukemia cells, as well as in hematopoietic stem cells.	9305596
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Fifty-nine consecutive patients (median age 45, range 18-69) with acute myelogenous leukemia in first remission were enrolled on a study of high-dose cytarabine-mitoxantrone consolidation chemotherapy used as a method of in vivo purging for the purpose of autologous peripheral blood progenitor cell transplantation.	9305609
Cessation of life, Toxic effect	Stem Cell Exhaustion	Toxicity of autologous peripheral blood progenitor cell transplant included treatment-related death in two patients and grade III/IV organ toxicity in six.	9305609
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Transplantation of autologous peripheral blood progenitor cells procured after high-dose cytarabine-based consolidation chemotherapy for adults with acute myelogenous leukemia in first remission.	9305609
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The purpose of the study was to evaluate the feasibility and efficacy of high-dose cytarabine-anthracycline consolidation chemotherapy followed by autologous transplantation of chemotherapy/rHuG-CSF-mobilized peripheral blood progenitor cells for adult patients with acute myelogenous leukemia in first remission.	9305609
Toxic effect, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Our results demonstrate that autologous transplantation of chemotherapy-mobilized peripheral blood progenitor cells is feasible in an unselected population of adult patients with acute myelogenous leukemia in first remission producing improved leukemia-free survival with minimal toxicity.	9305609
Neoplasms, Multiple Myeloma	Stem Cell Exhaustion	Sequential analysis of bone marrow and peripheral blood after stem cell transplant for myeloma shows disparate tumor involvement.	9305613
Multiple Myeloma	Stem Cell Exhaustion	Increasingly, peripheral blood (PB) stem cell transplants (PBSCT) are being used along with chemotherapy and total body irradiation as treatment for multiple myeloma.	9305613
Neoplasms	Stem Cell Exhaustion	Therefore, one potential problem with PBSCT is contamination of the stem cell harvests with tumor cells.	9305613
Neoplasms	Stem Cell Exhaustion	In an attempt to identify and quantitate the residual tumor within sequential BM and PB samples of patients with MM following autologous PB stem cell transplants we have used a tumor-specific detection assay, allele-specific oligonucleotide-PCR (ASO-PCR).	9305613
Precursor cell lymphoblastic lymphoma	Stem Cell Exhaustion	[Double autologous peripheral blood stem cell transplantation (double APBSCT) for lymphoblastic lymphoma].	9311276
Pancytopenia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Since reduced marrow cellularity and prolonged pancytopenia following autologous bone marrow transplantation (ABMT) have been frequently observed in patients with acute myelogenous leukemia (AML) included in the AML10 GIMEMA/EORTC trial, the question was raised to what extent hematopoietic and microenvironmental progenitor cells were involved in these patients.	9313879
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	These studies show that conditions that support normal LTC-IC also allow a functionally analogous but rare AML progenitor cell type to be detected.	9326221
Disease, Paroxysmal nocturnal hemoglobinuria, Marrow Toxic Injury	Stem Cell Exhaustion	Thus, the comparative resistance to apoptosis supports the pathogenic implication of apoptosis in marrow injury of PNH and related stem cell disorders.	9326238
Adenocarcinoma	Stem Cell Exhaustion	PDNC and associated adenocarcinoma appear to be derived from the same cell of origin, which is most likely either a pluripotent epithelial stem cell or an adenocarcinoma precursor cell.	9326914
Adenocarcinoma, Colorectal Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Since it is unclear whether PDNC originates from neoplastic transformation of preexisting neuroectodermal cells, pluripotent epithelial stem cells, or adenocarcinoma precursor cells, we investigated the histogenesis of this type of cancer by performing genetic analyses on a series of colorectal tumors.	9326914
Neoplasms	Stem Cell Exhaustion	Telomerase is an RNA-containing enzyme associated with immortality in proliferating stem cells and many tumors.	9329458
Aggressive Non-Hodgkin Lymphoma, Failure	Stem Cell Exhaustion	High dose chemotherapy and stem cell rescue for aggressive non-Hodgkin's lymphoma: pattern of failure and implications for involved-field radiotherapy.	9336141
Aggressive Non-Hodgkin Lymphoma, Failure, Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	To evaluate the pattern of failure and outcome of patients with aggressive non-Hodgkin's lymphoma (NHL) undergoing high-dose chemotherapy (HDCT) and autologous stem cell rescue (SCR) with an emphasis on the role of adjuvant involved-field radiotherapy (IFRT).	9336141
Rheumatoid Arthritis	Stem Cell Exhaustion	A phase 1 study to address the safety and efficacy of granulocyte colony-stimulating factor for the mobilization of hematopoietic progenitor cells in active rheumatoid arthritis.	9336419
Rheumatoid Arthritis	Stem Cell Exhaustion	To examine the safety and efficacy of granulocyte colony-stimulating factor (G-CSF) alone for the mobilization of peripheral blood progenitor cells in patients with resistant active rheumatoid arthritis (RA).	9336419
Multiple Myeloma	Stem Cell Exhaustion	Stem cells should be collected before melphalan administration in patients with multiple myeloma who are candidates for possible blood cell transplantation.	9339752
Toxic effect	Stem Cell Exhaustion	Current efforts to improve therapeutic efficacy have concentrated on decreasing drug toxicity and increasing drug doses (e.g., high-dose chemotherapy with peripheral stem cell support).	9348573
Structure of subclavian artery, Pulmonary Aspergillosis	Stem Cell Exhaustion	Invasive pulmonary aspergillosis complicated by subclavian artery occlusion following allogeneic stem cell transplantation.	9352750
Structure of subclavian artery, Pulmonary Aspergillosis, Aplastic Anemia	Stem Cell Exhaustion	We describe an unusual case of invasive pulmonary aspergillosis (IPA) complicated by subclavian artery occlusion in a 32-year-old man with severe aplastic anemia, who underwent allogeneic stem cell transplantation.	9352750
PAFAH1B1 wt Allele	Stem Cell Exhaustion	The low treatment-related mortality rate of less than 10% supports the view that sufficient numbers of hematopoietic stem cells are present in patients with MDS to allow adequate repopulation after autologous stem-cell transplantation.	9354651
Childhood Breast Carcinoma	Stem Cell Exhaustion	A 54-year-old woman with metastatic breast cancer, but otherwise in good health, had just begun a fifth collection of hematopoietic peripheral blood progenitor cells by leukapheresis.	9354826
Neoplasms	Stem Cell Exhaustion	Peripheral blood stem cell (PBSC) collections have nearly completely replaced bone marrow stem cell (BMSC) harvests because of the perceived advantages of more rapid engraftment, less tumor contamination in the inoculum, and better survival after therapy.	9360784
Acute leukemia	Stem Cell Exhaustion	Six months later, the blasts were positive for CD7, CD34 and HLA-DR. On the basis of morphologic, biochemical and immunophenotypic features, the patient was diagnosed acute leukemia, probably arising at a primitive multipotential stem cell level.	9364871
Multiple Myeloma	Stem Cell Exhaustion	[Allogeneic peripheral blood stem cell transplantation for multiple myeloma].	9364872
Multiple Myeloma	Stem Cell Exhaustion	We report here with a 46-year-old man with refractory multiple myeloma receiving allogeneic peripheral blood stem cell transplantation from his HLA-matched brother.	9364872
Limbal stem cell deficiency, Corneal Stroma	Stem Cell Exhaustion	The lack of corneal epithelial phenotype even on an avascular corneal stroma supports the concept that conjunctival transdifferentiation does not occur in vivo, and indicates that additional limbal stem cell transplantation is needed for effective corneal surface reconstruction in patients with limbal deficiency.	9366664
T-Cell Lymphoma	Stem Cell Exhaustion	Subcutaneous T-cell lymphoma treated with systemic chemotherapy, autologous stem cell support, and limb amputation.	9366846
T-Cell Lymphoma	Stem Cell Exhaustion	We describe subcutaneous T-cell lymphoma in a 39-year-old man who was treated with systemic chemotherapy, autologous stem cell support, and amputation of the limb primarily involved with the lymphomatous infiltrate.	9366846
Hematologic Neoplasms	Stem Cell Exhaustion	A pilot study evaluating interleukin-2-activated hematopoietic stem cell transplantation for hematologic malignancies.	9368182
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Peripheral blood progenitor cell transplantation as an alternative to autologous marrow transplantation in the treatment of acute myeloid leukemia.	9368339
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Herein we report on the feasibility of mobilizing peripheral blood progenitor cells (PBPC) in a prospective study of the HOVON-SAKK Groups in 96 cases with newly diagnosed acute myeloid leukemia (AML).	9368339
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	In conclusion, our results show that high-dose chemotherapy and autologous stem cell transplantation is a safe procedure which should be considered for the front-line treatment of non-Hodgkin lymphoma patients with poor prognostic features.	9375759
Lymphoma cells	Stem Cell Exhaustion	BEAM chemotherapy and autologous haemopoietic progenitor cell transplantation as front-line therapy for high-risk patients with diffuse large cell lymphoma.	9375759
disease stage	Stem Cell Exhaustion	In two consecutive and unselected cohorts of diffuse large cell lymphoma (DLCL) patients with advanced stage disease (IIB or bulk or more) and aged < 60 years, we compared a standard (MACOP-B for 12 weeks, 60 patients) versus a high-dose chemotherapy programme (8 weeks of MACOP-B plus one or two cycles of intensification with mitoxanthrone, dexamethasone, high-dose Ara-C, and finally BEAM chemotherapy with autologous haemopoietic progenitor cell transplantation, 61 patients).	9375759
Childhood Breast Carcinoma	Stem Cell Exhaustion	Peripheral blood progenitor cell mobilization using stem cell factor in combination with filgrastim in breast cancer patients.	9376574
Childhood Breast Carcinoma, Stem Cell Factor	Stem Cell Exhaustion	The safety and optimal dose and schedule of stem cell factor (SCF) administered in combination with filgrastim for the mobilization of peripheral blood progenitor cells (PBPCs) was determined in 215 patients with high-risk breast cancer.	9376574
Malignant neoplasm of testis, Childhood Breast Carcinoma	Stem Cell Exhaustion	We investigated the effects of peripheral blood progenitor cell (PBPC) apheresis on the kinetics and level of platelet membrane antigen expression in 11 breast cancer and 13 testicular cancer patients.	9377070
Lesion of breast	Stem Cell Exhaustion	Improvements in treatment may involve the use of fine needle aspiration of breast lesion prior to surgery, primary CNS prophylaxis in high grade disseminated disease and high dose chemotherapy with marrow/stem cell rescue in relapsed cases.	9378471
Neoplasms	Stem Cell Exhaustion	The bcl-2 protein is therefore thought to play a role in maintaining the stem-cell population in the peripheral layers of the tumor nests from which proliferating cells can be recruited.	9379422
Kidney Failure, Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy and autologous peripheral blood stem cell transplantation in patients with multiple myeloma and renal insufficiency.	9383228
Chronic Kidney Insufficiency, Multiple Myeloma	Stem Cell Exhaustion	Six patients with multiple myeloma and chronic renal insufficiency (serum creatinine >3.0 mg/dl), including four on dialysis, received high-dose busulfan and cyclophosphamide (BUCY) followed by autologous peripheral stem cell transplantation.	9383228
Kidney Failure, Multiple Myeloma	Stem Cell Exhaustion	Our experience suggests that high-dose therapy with BUCY and autologous peripheral blood stem cell rescue is feasible in patients with multiple myeloma and renal failure.	9383228
Autosomal Recessive Osteopetrosis	Stem Cell Exhaustion	Transplantation of cord blood progenitor cells can promote bone resorption in autosomal recessive osteopetrosis.	9383237
Oliguria	Stem Cell Exhaustion	A larger volume decreases the concentration of osteoblast progenitor cells because of dilution of the bone-marrow sample with peripheral blood.	9384430
Lymphoma, Non-Hodgkin, Specialty Type - cancer	Stem Cell Exhaustion	High-dose chemotherapy and peripheral blood stem cell infusion in patients with non-Hodgkin's lymphoma: results of outpatient treatment in community cancer centers.	9384477
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin, Specialty Type - cancer	Stem Cell Exhaustion	The outcomes for patients with non-Hodgkin's lymphoma (NHL) treated with high-dose chemotherapy (HDC) and peripheral blood stem cell (PBSC) infusion by practicing oncologists in community cancer centers in the United States were determined.	9384477
Convulsions, Blindness, Cortical	Stem Cell Exhaustion	Reversible cortical blindness and convulsions with cyclosporin A toxicity in a patient undergoing allogeneic peripheral stem cell transplantation.	9384485
Follicle, Thyroid carcinoma	Stem Cell Exhaustion	Recent studies indicate that mixed carcinoma of the thyroid may be derived from common stem cells in posterior branchia capable of differentiating into both follicular and parafollicular tumor cells.	9388857
Hematologic Neoplasms	Stem Cell Exhaustion	Transplantation of filgrastim-mobilized peripheral blood stem cells from HLA-identical sibling or alternative family donors in patients with hematologic malignancies: a prospective comparison on clinical outcome, immune reconstitution, and hematopoietic chimerism.	9389688
Hematologic Neoplasms	Stem Cell Exhaustion	The clinical results, cellular immune reconstitution, and hematopoietic chimerism obtained after transplantation of recombinant human granulocyte colony-stimulating factor mobilized allogeneic peripheral blood stem cells (PBSCs) from genotypically human leukocyte antigen (HLA)-identical sibling (n = 36) or alternative family donors (n = 24) were prospectively compared in patients with hematologic malignancies.	9389688
Intestinal metaplasia	Stem Cell Exhaustion	In disease, the gastric stem cell can assume the capacity of the duodenal stem cell for divergent differentiation into either intestinal goblet cells (for example, as in intestinal metaplasia) or Brunner's gland cells (for example, as in pyloric gland/Brunner's gland metaplasia).	9389974
Specialty Type - cancer	Stem Cell Exhaustion	Telomerase activity is readily detected in most cancer biopsies, but not in premalignant lesions or in normal tissue samples with a few exceptions that include germ cells and hemopoietic stem cells.	9391085
Lymphoma	Stem Cell Exhaustion	The data obtained suggests a neoplastic transforming event in lymphoid stem cells, which preceded the subsequent differentiation process into either B or T lymphoma.	9395182
Peripheral Blood Stem Cells	Stem Cell Exhaustion	High dose chemotherapy, with carboplatine (200 mg/m2 x 4 days), etoposide (250 mg/m2 x 4 days) and cyclophosphamide (50 mg/kg x 2 days) was performed in combination with peripheral blood stem cell autotransplantation.	9396264
Neoplasms, Multiple Myeloma	Stem Cell Exhaustion	The possibility of reducing tumour cell contamination by cytotoxic drug courses prior to peripheral blood progenitor cell (PBPC) collection was evaluated in two consecutives groups of multiple myeloma (MM) patient candidates for autograft.	9401085
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Autologous peripheral blood stem cell transplantation for acute myelogenous leukemia.	9404921
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The safety and efficacy of myeloablative therapy followed by autologous peripheral blood stem cell transplantation (ABSCT) for acute myelogenous leukemia (AML) were evaluated in 60 patients.	9404921
Hematologic Neoplasms	Stem Cell Exhaustion	A prospective, randomized, open study comparing two doses of teicoplanin with no therapy administered at the time of insertion of a central venous catheter was performed in patients with hematological malignancies and in patients scheduled to undergo allogeneic or autologous stem cell transplantation.	9406362
PAFAH1B1 wt Allele, Chromosome Aberrations	Stem Cell Exhaustion	Moreover, our data suggest that MM and MDS may arise from a common stem cell, which may be characterized by a clonal cytogenetic abnormality.	9406577
Ewings sarcoma	Stem Cell Exhaustion	Comparison of Technetium-99m sestamibi and indium-111 octreotide imaging in a patient with Ewing's sarcoma before and after stem cell transplantation.	9406698
Ewings sarcoma	Stem Cell Exhaustion	We report the use of two novel nuclide agents, Technetium-99m (99Tc)sestamibi (MIBI) and indium-111 (In-111) octreotide, in comparison with conventional computed tomography (CT) imaging in a patient with metastatic Ewing's sarcoma (ES) before and after high dose chemotherapy with autologous peripheral stem cell transplantation (PSCT).	9406698
Hematological Disease	Stem Cell Exhaustion	The ultimate goal of human gene therapy in treating hematopoietic disorders is to insert a functional copy of the affected gene into self-renewing stem cells.	9406995
Polycythemia Vera, Myeloproliferative disease	Stem Cell Exhaustion	Polycythaemia vera (PV) is a myeloproliferative disorder characterized by haematopoietic progenitor cells being hypersensitive to cytokines such as erythropoietin, interleukin-3, stem cell factor and insulin-like growth factor 1, which results in an increased production of mature blood cells.	9414643
Polycythemia Vera	Stem Cell Exhaustion	No evidence for an altered mRNA expression or protein level of haematopoietic cell phosphatase in CD34+ bone marrow progenitor cells or mature peripheral blood cells in polycythaemia vera.	9414643
Experimental Organism Basal Cell Carcinoma	Stem Cell Exhaustion	Expression of stem cell factor in basal cell carcinoma.	9415229
Skin Basal Cell Carcinoma	Stem Cell Exhaustion	Stem cell factor (SCF) distribution in basal cell carcinomas (BCCs) was examined by immunohistochemistry.	9415229
Lymphoma, Polyarthritis, "Sjogrens Syndrome	Stem Cell Exhaustion	Remission of nonerosive polyarthritis associated with Sjogren's syndrome after autologous hematopoietic stem cell transplantation for lymphoma.	9415659
Rheumatoid Arthritis, Lymphoma, Non-Hodgkin, "Sjogrens Syndrome	Stem Cell Exhaustion	We describe a 50-year-old woman with seropositive rheumatoid arthritis and Sjogren's syndrome who underwent autologous blood stem cell transplantation after relapse of associated non-Hodgkin's lymphoma.	9415659
Gastric Small Cell Carcinoma, Secondary malignant neoplasm of bone	Stem Cell Exhaustion	[A case of complete remission of gastric endocrine cell carcinoma with multiple bone metastasis by combination chemotherapy and high-dose chemotherapy with autologous peripheral blood stem cell transplantation].	9422073
Spindle cell lipoma, Neoplasms, Angiomyofibroblastoma	Stem Cell Exhaustion	The male AMF-like tumor is a soft-tissue neoplasm of the male genital tract that shares clinicopathologic features and a proposed perivascular stem cell derivation with both the female angiomyofibroblastoma and spindle cell lipoma.	9422311
Cytomegalovirus Infections, Infant Acute Lymphoblastic Leukemia	Stem Cell Exhaustion	[Cord blood stem cell transplantation for infantile acute lymphoblastic leukemia after primary cytomegalovirus infection].	9423343
Infant Acute Lymphoblastic Leukemia	Stem Cell Exhaustion	We report a 1-year-old boy with infantile lymphoblastic leukemia in first complete remission who received a cord blood stem cell transplantation (CBSCT) from an HLA identical sibling.	9423343
Hyperactive behavior	Stem Cell Exhaustion	These changes may be the result of the previous hyperactivity of the non-irradiated bone marrow which could be a cause of stem cell compartment depletion.	9424757
Hypoplasia	Stem Cell Exhaustion	These results confirm experimental data concerning greater radiosensitivity and proliferative potential of CFU-F, forming compact colonies versus diffuse colony-forming CFU-F. Aplasia of the irradiated bone marrow and hypoplasia of the non-irradiated bone marrow 18-23 years after radiotherapy completion coexisted with normal circulating CFU-GM and granulocyte blood count suggesting a compensatory mechanism involving a mitotic amplification between the progenitor cell and the final differentiated cell.	9424757
BCR gene	Stem Cell Exhaustion	The effects of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3 and IL-6 on clonogenic growth of blast-cell progenitors from 19 immunologically defined CD10-positive B-lineage acute lymphoblastic leukemias (ALL) coexpressing (My+ALLs) or not (My-ALLs) myeloid antigens have been studied.	9426972
Hodgkin Disease, Adult Myelodysplastic Syndrome, Disease	Stem Cell Exhaustion	Hodgkin's disease coexisting with myelodysplastic syndrome prior to therapy: a case report and a review of the association of Hodgkin's disease with stem cell disorders.	9433381
Disease, HD Term Type	Stem Cell Exhaustion	Since these cases raise the possibility of a stem cell association with HD, we reviewed the literature for other stem cell disorders with similar association with HD prior to aggressive therapy.	9433381
Disease, PAFAH1B1 wt Allele	Stem Cell Exhaustion	Four cases of stem cell disorders other than MDS were reported.	9433381
Disease, HD Term Type	Stem Cell Exhaustion	The association between HD and stem cell disorders, although rare, may need to be investigated further.	9433381
Hematologic Neoplasms	Stem Cell Exhaustion	Allogeneic peripheral blood stem cell (PBSC) transplant has recently been introduced for the treatment of hematological malignancies.	9434821
Deficiency	Stem Cell Exhaustion	To describe a group of patients with limbal stem cell (SC) deficiency without prior diagnosis of a specific disease entity known to be causative of SC deficiency.	9436878
Deficiency	Stem Cell Exhaustion	Because the SC deficiency is the result of prior ocular surgery and long-term topical medications, we propose the term "iatrogenic limbal stem cell deficiency."	9436878
Multiple Myeloma	Stem Cell Exhaustion	Peripheral blood progenitor cell mobilisation in patients with multiple myeloma following oral idarubicin and dexamethasone (Z-Dex) induction therapy.	9436937
Multiple Myeloma	Stem Cell Exhaustion	Difficulties associated with current intensive induction regimens for multiple myeloma and uncertainty as to how to achieve optimal peripheral blood progenitor cell mobilisation (PBPC) prompted this study of an oral induction regimen, Z-Dex (oral idarubicin and dexamethasone) followed by PBPC mobilisation using four different regimens.	9436937
Deficiency	Stem Cell Exhaustion	To describe a group of patients with limbal stem cell (SC) deficiency without prior diagnosis of a specific disease entity known to be causative of SC deficiency.	9440165
Medial collateral ligament, Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Stem Cell Exhaustion	The role for high-dose therapy and autologous stem-cell transplantation in mantle-cell lymphoma (MCL) is unknown.	9440717
Specialty Type - cancer	Stem Cell Exhaustion	Here we report the results of a phase I clinical trial that tested the safety and efficacy of transfer of the human multiple drug resistance (MDR1, MDR) gene into hematopoietic stem cells and progenitors in bone marrow as a means of providing resistance of these cells to the toxic effects of cancer chemotherapy.	9440739
Medulloblastoma	Stem Cell Exhaustion	High-dose carboplatin, thiotepa, and etoposide with autologous stem-cell rescue for patients with recurrent medulloblastoma.	9440746
Medulloblastoma	Stem Cell Exhaustion	This study evaluated the use of high-dose carboplatin, thiotepa, and etoposide with autologous stem-cell rescue (ASCR) in patients with recurrent medulloblastoma.	9440746
Stem Cell Factor, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The response of human acute myelogenous leukemia (AML) cells to four different hematopoietic growth factors (granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-1 beta (IL-1beta), interleukin-3 (IL-3), and stem cell factor (SCF)) and the relationship of the proliferative response of the AML cells to treatment outcome were studied.	9447830
Multiple Myeloma	Stem Cell Exhaustion	The suppression of progenitor cells was not restricted to B-lymphoid differentiation, as total CD34+ cells were also significantly reduced in the marrow of myeloma patients at presentation.	9450807
Multiple Myeloma	Stem Cell Exhaustion	B-lymphocyte suppression in multiple myeloma is a reversible phenomenon specific to normal B-cell progenitors and plasma cell precursors.	9450807
Multiple Myeloma	Stem Cell Exhaustion	The majority of these antigens are expressed by normal B-cell progenitors, indicating that myeloma also affects the early stages of B-cell development.	9450807
Aggressive Non-Hodgkin Lymphoma, Hodgkin Disease	Stem Cell Exhaustion	High-dose busulfan, melphalan, and thiotepa followed by autologous peripheral blood stem cell transplantation in patients with aggressive lymphoma or relapsed Hodgkin's disease.	9450921
Aggressive Non-Hodgkin Lymphoma, Lymphoma, Non-Hodgkin, Familial, HD Term Type, Hodgkin Disease	Stem Cell Exhaustion	The purpose of this study was to evaluate the efficacy of high-dose chemotherapy with busulfan (Bu), melphalan (Mel), and thiotepa (TT), and of autologous peripheral blood stem cell (PBSC) infusion in patients with aggressive non-Hodgkin's lymphoma (NHL) or relapsed Hodgkin's disease (HD).	9450921
Neoplasms	Stem Cell Exhaustion	The immunohistochemical results of the current study may support the hypothesis of a common stem cell origin of this tumor.	9452269
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Fluorescence in situ hybridization on methylcellulose cultured hematopoietic stem cells from myelodysplastic syndromes.	9460494
Concomitant Medication Submission Domain, Stem Cell Factor	Stem Cell Exhaustion	ELISA documented high amounts of granulocyte colony-stimulating factor (G-CSF; > 5 ng/ml); also granulocyte-macrophage CSF (GM-CSF), macrophage-CSF (M-CSF), stem cell factor (SCF), IL-6, and IL-8 were detected in KU-19-19 CM.	9464244
Nephroblastoma	Stem Cell Exhaustion	Double high-dose chemotherapy with autologous peripheral stem cell rescue in relapsed Wilms' tumor.	9466289
Nephroblastoma	Stem Cell Exhaustion	We performed double high-dose chemotherapy (HDCT) and autologous stem cell rescue (ASCR) on an 8-year-old girl after relapse of Wilms' tumor with unfavorable histology.	9466289
Polycythemia Vera	Stem Cell Exhaustion	The cause of polycythemia vera, which originates from a multipotent hematopoietic progenitor cell, is unknown.	9475764
Hematopoiesis, Myeloproliferation, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	An injury to the hemopoietic stem cell may lead to the aplasia of hemopoiesis, myelodysplasia and to an unregulated myeloproliferation.	9476375
Tumor necrosis, Stem Cell Factor	Stem Cell Exhaustion	In contrast, marked differences were not found in the levels of interleukin-3 (IL-3), tumor necrosis factor-alpha (TNF-alpha), stem cell factor (SCF), granulocyte/macrophage-colony stimulating factor (GM-CSF), or interferon-gamma) (IF-gamma).	9479872
Disease, Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	The cytokine profiles may support a pathological relationship between PNH and these stem cell disorders.	9479872
Myeloproliferative disease, 8p11	Stem Cell Exhaustion	t(6;8), t(8;9) and t(8;13) translocations associated with stem cell myeloproliferative disorders have close or identical breakpoints in chromosome region 8p11-12.	9484786
Myeloproliferative disease	Stem Cell Exhaustion	A stem-cell myeloproliferative disorder involving T- and B-cell, and myeloid lineages, is associated with three different translocations with a breakpoint in region p11-12 of chromosome 8: t(6;8)(q27;p11), t(8;9)(p11;q33), and t(8;13)(p12;q12), respectively.	9484786
leukemia	Stem Cell Exhaustion	Twenty-seven patients above 40 years of age (range 40-55) with leukaemia underwent transplantation with haematopoietic stem cells from HLA-A, -B and -DR identical unrelated donors.	9486493
Meningoencephalitis	Stem Cell Exhaustion	Trichomonas foetus meningoencephalitis after allogeneic peripheral blood stem cell transplantation.	9486501
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 34-year-old man with refractory acute myelogenous leukemia underwent allogeneic peripheral blood stem cell transplantation (PBSCT) from his HLA-matched sibling.	9486501
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	These findings support the notion that autologous PBSCT in CML whilst serving as a therapeutic manoeuvre may also facilitate the collection of non-leukaemic progenitor cells for further transplantation procedures.	9486504
Multiple Myeloma	Stem Cell Exhaustion	Autologous peripheral blood stem cell transplantation for multiple myeloma: a report of 259 cases from the Spanish Registry.	9489629
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Between January 1989 and November 1995, 259 patients with multiple myeloma (MM), 22 stage I, 57 stage II and 180 stage III at diagnosis were treated with myeloablative high-dose therapy followed by autologous peripheral blood stem cell (PBSC) transplantation.	9489629
Multiple Myeloma	Stem Cell Exhaustion	Autologous CD34-selected blood progenitor cell transplants for patients with advanced multiple myeloma.	9489630
Multiple Myeloma	Stem Cell Exhaustion	Fifty-five patients with advanced multiple myeloma received purified CD34-selected peripheral blood progenitor cell transplants following myeloablative chemotherapy.	9489630
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation for aggressive non-Hodgkin's lymphomas in first complete or partial remission: a retrospective analysis of the outcome of 52 patients according to the age-adjusted International Prognostic Index.	9489649
Aggressive Non-Hodgkin Lymphoma, Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	The aim of the study was to retrospectively evaluate the outcome of patients with aggressive non-Hodgkin's lymphoma (NHL), undergoing autologous stem cell transplantation (ASCT) in first complete (CR) or partial (PR) remission, according to the age-adjusted International Prognostic Index (IPI).	9489649
Pneumonia, Interstitial	Stem Cell Exhaustion	Fatal cytomegalovirus interstitial pneumonia following autologous peripheral blood stem cell transplantation.	9489656
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 52-year-old Japanese woman suffering from AML (FAB classification M4) in her first remission received an autologous peripheral blood stem cell transplant (APBSCT).	9489656
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic peripheral blood stem cell transplantation from an HLA-identical sibling was performed for a 38-year-old male with refractory acute myeloblastic leukemia.	9495377
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Bone marrow necrosis in a patient with acute myeloblastic leukemia during administration of G-CSF and rapid hematologic recovery after allotransplantation of peripheral blood stem cells.	9495377
Central Nervous System, Multiple Myeloma	Stem Cell Exhaustion	Central nervous system relapses after autologous stem cell transplantation for myeloma.	9497892
Specialty Type - cancer	Stem Cell Exhaustion	The cellular characteristics of steady-state peripheral blood progenitor cell (PBPC) apheresis, including total number of lymphomononuclear cells, CD34 and CFUs, was evaluated in a group of 26 chemo-radiotherapy patients as well as in a group of 23 surgically resected cancer patients.	9499829
Childhood Breast Carcinoma	Stem Cell Exhaustion	Eight patients with advanced breast cancer were entered into a prospective, longitudinal trial that included examination by MR imaging and proton MR spectroscopy before chemotherapy and through 12 months after treatment with carmustine, cyclophosphamide, and cisplatin, combined with autologous hematopoietic progenitor cell support (AHPCS).	9504468
Neoplasm of skin with adnexal differentiation, Neoplasms	Stem Cell Exhaustion	Mutations in genes regulating proliferation and differentiation of putative stem cells of the FSAU would give rise to different combinations of adnexal skin tumors as well as to other neoplasms.	9504671
Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	Effect of interface/offset (I/O) adjustment on collection efficiency using the Fenwal CS3000 Plus Blood Cell Separator for peripheral blood progenitor cell collection.	9507381
Malignant Neoplasms	Stem Cell Exhaustion	Large-volume leukapheresis (LVL), defined as the processing of at least three blood volumes in a single session for peripheral blood progenitor cell (PBPC) collection, was performed in 32 small children weighing < or = 25 kg, aged 10 months to 8 years, with a variety of malignancies.	9507382
Lymphoma, Non-Hodgkin, Familial, T-Cell Lymphoma	Stem Cell Exhaustion	This study evaluated the outcomes of patients who received high-dose chemotherapy (HDC) and autologous hematopoietic stem-cell transplantation (ASCT) for large-cell non-Hodgkin's lymphoma (NHL) and the effect of a follicular versus a diffuse histology.	9508164
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	These results suggest that the NOD/SCID mouse may allow greater engraftment and amplification of both normal and leukemic (Ph+) cells sufficient for the quantitation and characterization of the normal and leukemic stem cells present in patients with CML.	9516140
Toxic effect	Stem Cell Exhaustion	Current efforts to improve therapeutic efficacy have concentrated on decreasing drug toxicity and increasing drug doses (e.g., high-dose chemotherapy with peripheral stem-cell support).	9516601
Testicular Myeloid Sarcoma, Multiple Myeloma	Stem Cell Exhaustion	We present a case of a 55 year old man with multiple myeloma who underwent autologous stem cell transplantation and subsequently developed testicular myeloma.	9517517
Leukemia, Myelomonocytic, Chronic, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The degree of lineage commitment of the hematopoietic stem cell in chronic myelomonocytic leukemia (CMML) and in acute myelogenous leukemia (AML) remains debatable and may be heterogeneous depending on the patient subgroup.	9519789
Breast Carcinoma, Pleural Effusion, CTCAE	Stem Cell Exhaustion	A 43-yr-old woman with recently diagnosed breast carcinoma presented with a right pleural effusion after a cycle of adjuvant, high-dose chemotherapy supported by peripheral blood progenitor cells (PBPC) and granulocyte-colony-stimulating factor (G-CSF, Filgrastim).	9523139
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Interferon-alpha (IFN-alpha) is considered the standard therapy for chronic myeloid leukemia (CML) patients not suitable for allogeneic stem cell transplantation.	9531580
Neoplasms	Stem Cell Exhaustion	A simplified cryopreservation method for bone marrow (BM) and peripheral blood progenitor cells (PBPC) was utilized in hematopoietic cell transplantation of 213 patients with hematological or solid neoplasms after ablative chemotherapy (187 with peripheral blood progenitor cells and 26 with bone marrow).	9535044
Myelosuppression, Herpes Simplex Infections, Mycoses	Stem Cell Exhaustion	SK&F107647 is a synthetic hematoregulatory peptide (HP) increases both the number and function of progenitor cells, enabling improved survival after lethal myelosuppression, lethal fungal infection, and lethal herpes simplex virus infection in murine models.	9537210
Graft-vs-Host Disease	Stem Cell Exhaustion	A case of chronic graft-versus-host-disease following allogeneic peripheral blood stem cell rescue for poor graft function after bone marrow transplantation.	9538634
Malignant Neoplasms	Stem Cell Exhaustion	In an attempt to investigate whether the use of these two mobilization regimens could result in the collection of functionally different CD34+ cells, we analyzed nucleated cells (NC), CD34+ cells, committed progenitor cells and long-term culture initiating-cells (LTC-IC) in 52 leukaphereses from 26 patients with lymphoid malignancies, mobilized either by CY+G-CSF (n=16) or G-CSF alone (n=10).	9543059
Bacteremia	Stem Cell Exhaustion	Streptococcus viridans bacteremia following autologous peripheral blood stem cell transplantation.	9543063
Streptococcus viridans	Stem Cell Exhaustion	A retrospective evaluation of 200 consecutive recipients of autologous peripheral blood stem cell transplantation was conducted to ascertain the incidence and outcome of Streptococcus viridans bacteremia as well as to determine the role of prophylactic ampicillin therapy in the peri-transplant setting.	9543063
Neutropenia, Infection	Stem Cell Exhaustion	The shorter duration of neutropenia observed after stem cell transplantation did not impact on the incidence of S. viridans infections.	9543063
Myelosuppression, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	[Successful syngeneic peripheral blood stem cell transplantation for protracted myelosuppression after chemotherapy in a patient with acute myelogenous leukemia].	9545830
Infectious agent, Myelosuppression	Stem Cell Exhaustion	Following intensive chemotherapy, he received rhG-CSF-mobilized peripheral blood stem cell transplantation (PBSCT) from an identical twin because he had life threatening infectious events and protracted myelosuppression.	9545830
Neoplasms, Lymphoma	Stem Cell Exhaustion	Among supermarket workers, wrapping meat (mainly a female activity) was associated with increased risk of tumors of the hemopoietic and lymphatic systems (OR = 3.8, 95% CI 1.0-14.3), with the odds of both lymphomas and tumors of the myeloid stem cell being elevated.	9554414
HIV, Decreased platelet count	Stem Cell Exhaustion	Thrombocytopenia has been characterized in six patients infected with human immunodeficiency virus (HIV) with respect to the delivery of viable platelets into the peripheral circulation (peripheral platelet mass turnover), marrow megakaryocyte mass (product of megakaryocyte number and volume), megakaryocyte progenitor cells, circulating levels of endogenous thrombopoietin (TPO) and platelet TPO receptor number, and serum antiplatelet glycoprotein (GP) IIIa49-66 antibody (GPIIIa49-66Ab), an antibody associated with thrombocytopenia in HIV-infected patients.	9558379
Malignant Neoplasms	Stem Cell Exhaustion	Mobilization of peripheral blood stem cells in patients with advanced thoracic malignancies after irinotecan (CPT-11) administration.	9568166
Mesothelioma, Malignant neoplasm of lung, Malignant Neoplasms	Stem Cell Exhaustion	We evaluated the mobilization of peripheral blood stem cells (PBSCs) after the administration of chemotherapy including irinotecan (CPT-11) in individuals with advanced thoracic malignancies including lung cancer and mesothelioma.	9568166
BCR gene	Stem Cell Exhaustion	In adult ALL, the role and optimal methods of stem cell transplantation are still under investigation.	9570681
Childhood Breast Carcinoma	Stem Cell Exhaustion	[A case report of neoadjuvant intra-arterial injection chemotherapy combined with peripheral blood stem cell reinfusion in an advanced breast cancer patient].	9571972
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Fanconi Anemia, Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	To investigate whether accelerated senescence of hematopoietic stem cells might underlie the pathophysiology of myelodysplasia (MDS) or paroxysmal nocturnal hemoglobinuria (PNH) occurring as a late complication of AA, we studied mean telomere length (TRF) in peripheral blood leukocytes from 79 patients with AA, Fanconi anemia, or PNH in comparison with normal controls.	9572992
Lymphoproliferative Disorders	Stem Cell Exhaustion	Semiquantitative Epstein-Barr virus (EBV) polymerase chain reaction for the determination of patients at risk for EBV-induced lymphoproliferative disease after stem cell transplantation.	9573001
Lymphoproliferative Disorders	Stem Cell Exhaustion	Epstein-Barr virus-induced lymphoproliferative disease (EBV-LPD) is a serious and potentially fatal complication after allogeneic stem cell transplantation (SCT).	9573001
Toxic effect, Childhood Breast Carcinoma	Stem Cell Exhaustion	Efficacy and toxicity of sequential high-dose therapy with peripheral blood stem cell support in patients with high-risk breast cancer.	9578056
Peripheral Blood Stem Cells, Toxic effect	Stem Cell Exhaustion	We studied toxicity and therapeutic efficacy of sequential high-dose therapy consisting of two cycles of ifosfamide 12,000 mg/m2, carboplatin 900 mg/m2, and epirubicin 180 mg/m2 (ICE) with peripheral blood stem cell support.	9578056
Peripheral Blood Stem Cells, Childhood Breast Carcinoma	Stem Cell Exhaustion	In conclusion, sequential high-dose therapy with peripheral blood stem cell support in patients with high-risk breast cancer can be administered safely and offers a potential benefit in the adjuvant setting.	9578056
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Recombinant human granulocyte colony-stimulating factor (filgrastim) following high-dose chemotherapy and peripheral blood progenitor cell rescue in high-grade non-Hodgkin's lymphoma: clinical benefits at no extra cost.	9579836
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	In order to evaluate the potential clinical and economic benefits of granulocyte colony-stimulating factor (G-CSF, filgrastim) following peripheral blood progenitor cells (PBPC) rescue after high-dose chemotherapy (HDCT), 23 consecutive patients aged less than 60 years with poor-prognosis, high-grade non-Hodgkin's lymphoma (NHL) were entered into a prospective randomized trial between May 1993 and September 1995.	9579836
Decortication (procedure)	Stem Cell Exhaustion	Decortication has been shown to promote the fusion process and provides not only a rich source of vascular supply from the underlying cancellous bone, but also access to pluripotent stem cells within the marrow.	9588465
Gastrointestinal Stromal Tumors	Stem Cell Exhaustion	We conclude that gastrointestinal stromal tumors show striking morphological and immunophenotypic similarities with ICC and that they may originate from stem cells that differentiate toward a pacemaker cell phenotype.	9588894
Hepatoblastoma, Neoplasms	Stem Cell Exhaustion	Peripheral blood stem cell transplantation for hepatoblastoma with microscopical residue: a therapeutic approach for incompletely resected tumor.	9591340
BCR gene	Stem Cell Exhaustion	Results suggest that Ph+ ALL originates from a pluripotent stem cell.	9593263
Retinal Hemorrhage, Leukocytosis	Stem Cell Exhaustion	Hyperleukocytosis and retinal hemorrhages after chemotherapy and Filgrastim administration for peripheral blood progenitor cell mobilization.	9603411
Sarcoma - category (morphologic abnormality)	Stem Cell Exhaustion	We investigated peripheral blood progenitor cell (PBPC) mobilization by disease-specific chemotherapy in patients with metastatic soft tissue sarcoma (STS).	9613776
Febrile Neutropenia	Stem Cell Exhaustion	Analysis of the value of empiric vancomycin administration in febrile neutropenia occurring after autologous peripheral blood stem cell transplants.	9613785
Communicable Diseases	Stem Cell Exhaustion	We conducted a retrospective review of 125 patients undergoing high-dose therapy and stem cell rescue in order to evaluate the incidence of documented infection and the utility of the administration of vancomycin empirically.	9613785
Hepatic Veno-Occlusive Disease, Leakage	Stem Cell Exhaustion	Hepatic veno-occlusive disease with severe capillary leakage after peripheral stem cell transplantation: treatment with recombinant plasminogen activator and C1-esterase inhibitor concentrate.	9613790
Venoocclusive disease	Stem Cell Exhaustion	Severe veno-occlusive disease (VOD), characterised by elevated serum bilirubin levels, is a known complication in the first 3 weeks after peripheral blood stem cell transplantation (PBSCT).	9613790
Childhood Desmoplastic Small Round Cell Tumor	Stem Cell Exhaustion	Benefit of aggressive multimodality therapy with autologous stem cell support for intra-abdominal desmoplastic small round cell tumor.	9613794
Aggressive course	Stem Cell Exhaustion	This case report suggests a role for autologous stem cell transplantation as part of multimodality therapy for this unusual and aggressive malignancy.	9613794
Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0, Anemia, Hemolytic	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic anemia resulting from a somatic mutation in a hemopoietic stem cell.	9616145
Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Circulating primitive stem cells in paroxysmal nocturnal hemoglobinuria (PNH) are predominantly normal in phenotype but granulocyte colony-stimulating factor treatment mobilizes mainly PNH stem cells.	9616145
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	Recent evidence has indicated, however, that the majority of the most primitive peripheral blood stem cells (PBSCs) in PNH appear to be of normal phenotype.	9616145
Fatigue	Stem Cell Exhaustion	[The quality of life after stem cell transplantation: problems with fatigue, sexuality, finances and employment].	9623238
Malignant Neoplasms	Stem Cell Exhaustion	To determine the quality of life in patients after high dose chemo/radiotherapy followed by bone marrow stem cell transplantation for the treatment of a malignancy.	9623238
European Organization for Research and Treatment of Cancer, Specialty Type - cancer	Stem Cell Exhaustion	All patients who had undergone stem cell transplantation (SCT) at least 6 months previously (n = 54) were asked to participate in an analysis of their quality of life using the 'Quality of life questionnaire' (QLQ-C30) developed by the European Organization for Research and Treatment of Cancer (EORTC) and an in-depth interview.	9623238
Specialty Type - cancer	Stem Cell Exhaustion	We analyzed blood stem-cell collections from 410 consecutive cancer patients who received mobilization therapy and evaluated factors, including CD34+ subset quantities, that might influence engraftment kinetics and transfusion requirements in autologous blood stem-cell recipients.	9626209
Specialty Type - cancer	Stem Cell Exhaustion	These findings show that CD34+33- cells are readily collected in most cancer patients and significantly influence engraftment kinetics and transfusion requirements in autologous blood stem-cell recipients.	9626209
Bone marrow hypocellularity, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	These data suggest the presence of a stem cell defect which may progress to myelodysplasia or overt marrow failure in these patients.	9628429
Central neuroblastoma	Stem Cell Exhaustion	Peripheral blood stem cell autografts for the treatment of children over 1 year old with stage IV neuroblastoma: a long-term follow-up.	9632274
Central neuroblastoma	Stem Cell Exhaustion	This is the first report of the long-term therapeutic results in 22 children more than 1 year old with stage IV neuroblastoma who were treated with autologous peripheral blood stem cell transplantation (PBSCT).	9632274
Multiple Myeloma	Stem Cell Exhaustion	Reduced progression-free survival in elderly patients receiving intensification with autologous peripheral blood stem cell reinfusion for multiple myeloma.	9632278
Peripheral Stem Cell Transplantation, Multiple Myeloma	Stem Cell Exhaustion	Between 1990 and 1997, 55 patients with high risk multiple myeloma underwent high-dose therapy with peripheral blood stem cell transplantation.	9632278
Pneumonia	Stem Cell Exhaustion	On day +6 after peripheral blood stem cell transplant (PBSCT) bacterial pneumonia developed.	9632283
Hodgkin Disease	Stem Cell Exhaustion	A 34-year-old man suffering from Hodgkin's disease underwent high-dose chemotherapy (CBV) followed by transplantation of autologous peripheral blood stem cells.	9632283
Respiratory Distress Syndrome, Newborn, Respiratory Distress Syndrome, Adult	Stem Cell Exhaustion	Successful management of adult respiratory distress syndrome (ARDS) after high-dose chemotherapy and peripheral blood progenitor cell rescue by non-invasive ventilatory support.	9632283
PAFAH1B1 wt Allele, Inosine Triphosphate, Aplastic Anemia, Immune thrombocytopenic purpura, Decreased platelet count, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	To evaluate the diagnostic value of thrombopoietin (TPO, c-mpl ligand) measurements, and clarify the regulatory mechanisms of TPO in normal and in thrombocytopenic conditions, the plasma TPO concentration was determined in normal individuals (n = 20), umbilical cord blood (n = 40), chronic idiopathic thrombocytopenic purpura (ITP; n = 16), in severe aplastic anaemia (SAA; n = 3), chemotherapy-induced bone marrow hypoplasia (n = 10), myelodysplastic syndrome (MDS; n = 11), and sequentially during peripheral blood progenitor cell transplantation (n = 7).	9633881
Lymphoma, Primary Induction Failure	Stem Cell Exhaustion	[Successful double peripheral blood stem cell transplantation for patient with malignant lymphoma of primary induction failure].	9637887
Lymphoma, Non-Hodgkin, Histology	Stem Cell Exhaustion	Three patients with non-Hodgkin's lymphoma of intermediate-grade histologies, who had failed to achieve a complete remission (CR) after more than several courses of conventional chemotherapy were treated with two cycles of high-dose chemotherapy with autologous peripheral blood stem cell transplantation (double PBSCT).	9637887
Peripheral Blood Stem Cells, Specialty Type - cancer	Stem Cell Exhaustion	The study, conducted at a cancer center, included both a retrospective evaluation of patients undergoing highly emetogenic high-dose chemotherapy with peripheral blood stem-cell rescue between November 1994 and December 1995 and a concurrent evaluation of patients treated between January and May 1996.	9640466
Renal Cell Carcinoma	Stem Cell Exhaustion	Prognostic value of stem cell line identification for renal cell carcinomas.	9642448
Renal Cell Carcinoma	Stem Cell Exhaustion	The present study clearly showed that stem cell line characterization, and particularly the presence of highly aneuploid cells (with > 5C DNA content), is associated in RCCs with significant prognostic value.	9642448
Neoplasms, Multiple Myeloma	Stem Cell Exhaustion	First and second apheresis in patients with multiple myeloma: no differences in tumor load and hematopoietic stem cell yield.	9645573
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Autologous peripheral blood stem cells (PBSC) are now widely used to support myeloablative therapy in patients with multiple myeloma (MM).	9645573
Acquired ichthyosis, Chronic graft-versus-host disease, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Acquired ichthyosis associated with chronic graft-versus-host disease following allogeneic peripheral blood stem cell transplantation in a patient with chronic myelogenous leukemia.	9645582
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We report a 29-year-old male, who underwent allogeneic peripheral blood stem cell transplantation (alloPBSCT) for chronic myelogenous leukemia, and who developed AI associated with chronic graft-versus-host disease (cGVHD).	9645582
Non-Secretory Plasma Cell Myeloma	Stem Cell Exhaustion	2.9 x 10(8)/kg donor mononuclear cells containing 1.4% CD34+ and 37% CD3+ cells were administered to a 48-year-old patient with non-secretory plasmablastic myeloma relapsing 9 months after a blood stem cell transplant from his HLA-identical sibling.	9645583
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Early stem cell transplantation for chronic lymphocytic leukaemia: a chance for cure?	9649148
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	To improve the prognosis of patients with CLL, we have designed a sequential treatment strategy that comprises intensive chemotherapy for mobilization of peripheral blood progenitor cells (PBPCs) and induction of minimal disease, followed by high-dose radiochemotherapy with stem cell reinfusion and post-transplant molecular monitoring by polymerase chain reaction (PCR) amplification of the complementary determining region III (CDRIII) gene.	9649148
Neoplasms, Lymphoma	Stem Cell Exhaustion	For stem cell mobilization and reduction of tumour load, one to two cycles of Dexa-BEAM chemotherapy were administered, resulting in minimal disease (circulating lymphoma cells <1 x 10(9) l(-1); BM infiltration <20%; lymphomas <2 cm) in 16 out of 18 patients, including four patients who already had minimal disease before Dexa-BEAM.	9649148
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	We conclude that sequential high-dose therapy using Dexa-BEAM and autologous stem cell transplantation is a safe and highly effective treatment for patients with CLL.	9649148
bone marrow toxicity	Stem Cell Exhaustion	We conclude that the method of combined bone marrow support by G-CSF and haematopoietic progenitor cells in autologous whole blood collected before each cycle of a 2-weekly regimen of cisplatin-ifosfamide does not result in clinically measurable reduced bone marrow toxicity compared with what can be expected by the use of G-CSF alone.	9649159
THM gene	Stem Cell Exhaustion	CD34, a stem cell marker, was expressed on 29.9 +/- 12.2% of CD4-CD8- cells in thymoma.	9649210
Malignant neoplasm of lung	Stem Cell Exhaustion	[A guide for the timing of peripheral blood stem cell harvest in patients with lung cancer].	9656667
Malignant neoplasm of lung	Stem Cell Exhaustion	Harvest of peripheral blood stem cells (PBSC) was performed 57 times in 17 lung cancer patients after standard-dose chemotherapy (cisplatin, etoposide) supplemented with granulocyte-colony stimulating factor (G-CSF).	9656667
THM gene	Stem Cell Exhaustion	[Invasive thymoma successfully treated with high-dose chemotherapy followed by peripheral blood stem cell transplantation(PBSCT)].	9656679
Harvesting of peripheral blood stem cells	Stem Cell Exhaustion	Four weeks after the 2 causes of ADOC, he was given 300 mg/m2 of etoposide for five days followed by G-CSF subcutaneously for peripheral blood stem cell collection.	9656679
Paroxysmal nocturnal hemoglobinuria, Hematopoietic stem cells, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired disorder of blood cells which originate from an abnormal hematopoietic stem cell.	9662906
Graves Disease	Stem Cell Exhaustion	An elevation of stem cell factor in patients with hyperthyroid Graves' disease.	9669287
Polycythemia Vera, Erythrocytosis	Stem Cell Exhaustion	Polycythemia vera (PV) is a clonal stem cell disorder characterized by excessive erythrocyte production, resulting in absolute erythrocytosis.	9669670
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	For patients with non-Hodgkin's lymphoma (NHL) undergoing blood or bone marrow transplantation (BMT), the use of autologous grafts has often been preferred to that of allogeneic stem cells because of a significantly lower incidence of non-relapse mortality.	9674848
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	The aim of the present trial was to investigate the feasibility of high-dose therapy followed by autologous peripheral blood stem cell transplantation (PBSCT) as a component of front-line treatment in patients with disseminated intermediate- and high-grade non-Hodgkin's lymphoma (NHL) aged 61-65 years.	9674850
Peripheral Blood Stem Cells, Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	High-dose therapy with peripheral blood stem cell (PBSC) support is a frequently used treatment option in younger patients with poor prognosis histologically indolent (low-grade) non-Hodgkin's lymphoma (NHL), usually at the time of second or subsequent response to conventional-dose therapy.	9674852
Lymphoma	Stem Cell Exhaustion	Progenitor cell yields are frequently poor in patients with histologically indolent lymphomas especially when mobilized within 6 months of previous chemotherapy.	9674852
Bone Marrow Diseases	Stem Cell Exhaustion	Progenitor cell yields may therefore be improved in patients with low grade lymphoma by harvesting at diagnosis if no marrow disease is present, or by delaying mobilization for 6 months post-chemotherapy in patients in first or subsequent remission.	9674852
Childhood Breast Carcinoma	Stem Cell Exhaustion	High-dose chemotherapy and autologous stem cell support followed by post-transplant doxorubicin and taxol as initial therapy for metastatic breast cancer: hematopoietic tolerance and efficacy.	9674853
Lymphoma, Thrombotic Microangiopathies	Stem Cell Exhaustion	Thrombotic microangiopathy of hyperacute onset after autologous peripheral blood stem cell transplantation in malignant lymphoma.	9674861
Neoplasms	Stem Cell Exhaustion	Double-conditioning regimens consisting of thiotepa, melphalan and busulfan with stem cell rescue for the treatment of pediatric solid tumors.	9678789
Stem Cell Factor	Stem Cell Exhaustion	The addition of stem cell factor (SCF) to G-CSF and chemotherapy results in a dose-dependent, significantly increased mobilisation of peripheral blood progenitor cells compared with the use of chemotherapy and G-CSF alone.	9678793
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The three patients may represent a distinct AML category with the following features: (1) the near-tetraploid karyotype in most bone marrow metaphases examined at diagnosis of AML; (2) the presence of very large myeloid blasts in the bone marrow and dysplastic changes in erythroid and/or megakaryocytic lineages pointing to the origin of AML in pluripotent myeloid progenitor cells; (3) the expression of the CD34 antigen; (4) the low growth of granulocyte-macrophage colony forming cells in culture; and (5) the presence of a preleukemic phase, a higher age and a poor prognosis.	9680107
Ewings sarcoma	Stem Cell Exhaustion	Adjuvant interleukin-2 (IL-2) therapy after stem cell transplantation can improve the prognosis of patients with Ewing tumors.	9680927
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Taken together, these studies indicate that residual haemopoietic progenitors are present in untreated CLL patients and that stem cell mobilization and collection can be carried out following fludarabine treatment.	9688287
Hematologic Neoplasms	Stem Cell Exhaustion	Predictive parameters for mobilized peripheral blood CD34+ progenitor cell collection in patients with hematological malignancies.	9692386
Hematologic Neoplasms	Stem Cell Exhaustion	In order to investigate what is the best single parameter to predict the leukapheretic yield of circulating CD34+ progenitor cells, we retrospectively analyzed data from 68 patients with hematological malignancies who underwent mobilizing therapy.	9692386
Neutropenia, Fever, leukemia	Stem Cell Exhaustion	The study population was at serious risk of a poor outcome, since 67% of the patients had leukemia or lymphoma, 19% of the febrile events occurred after autologous bone marrow or blood stem cell transplantation, the median total duration of neutropenia was 16 days, and the median neutrophil count at study inclusion was 0.09 x 10(9)/1.	9695210
Disease, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Aplastic Anemia, Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	Among acquired stem cell disorders, pathological links between myelodysplastic syndromes (MDS) and aplastic anaemia (AA), and paroxysmal nocturnal haemoglobinuria (PNH) and AA, have been often described, whereas the relationship between MDS and PNH is still unclear.	9695961
Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy (melphalan) with autologous marrow stem cell support (AMSCS) results in high response rates in multiple myeloma (MM), with up to 50% of patients achieving complete remission.	9695964
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Our results suggest MGDF as a potent agent to augment progenitor cell mobilization after successful induction or consolidation chemotherapy in patients with AML.	9695971
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Recombinant human megakaryocyte growth and development factor increases levels of circulating haemopoietic progenitor cells post chemotherapy in patients with acute myeloid leukaemia.	9695971
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	By participating in a randomized safety and efficacy study of pegylated-recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) post induction and consolidation chemotherapy for de novo acute myeloid leukaemia, serial determinations of circulating haemopoietic progenitor cells were performed during 18 chemotherapy courses in eight patients (three receiving placebo; one, 2.5; and four, 5.0 microg/kg/d MGDF, respectively).	9695971
Malignant neoplasm of ovary	Stem Cell Exhaustion	The role of an even higher dose mitoxantrone schedule employed as a component of a high dose chemotherapy program with bone marrow or peripheral progenitor cell protection in the treatment of ovarian cancer remains to be defined.	9698488
Symptoms	Stem Cell Exhaustion	We evaluated 197 patients undergoing autologous transplantation for intestinal symptoms; the source for hematopoietic cells was marrow (n=32), peripheral blood stem cells (n=146), or both (n=19).	9701391
Multiple Myeloma	Stem Cell Exhaustion	For patients younger than 60 years with multiple myeloma in a stage requiring chemotherapy high dose chemotherapy followed by autologous blood stem cell transplantation appears to be the best therapeutic option.	9702091
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Acute Myeloid Leukemia with Myelodysplasia-Related Changes	Stem Cell Exhaustion	Pre-B acute lymphoblastic leukemia in a 3-year-old boy with pre-acute myelogenous leukemia myelodysplastic syndrome: cytogenetic evidence of common early progenitor cell ontogeny.	9703011
Anemia, Malignant Neoplasms, BCR gene	Stem Cell Exhaustion	This case presents cytogenetic evidence of common early progenitor cell ontogeny of both malignancies (refractory anemia with excess blasts and ALL).	9703011
Tuberculosis	Stem Cell Exhaustion	Tuberculosis (TB) is generally seen in immunodeficient states and its incidence would be expected to increase after hematopoietic stem cell transplantation (SCT), particularly in the allogeneic setting.	9704259
Malignant neoplasm of ovary	Stem Cell Exhaustion	Randomized comparison of progenitor-cell mobilization using chemotherapy, stem-cell factor, and filgrastim or chemotherapy plus filgrastim alone in patients with ovarian cancer.	9704709
Stem Cell Factor	Stem Cell Exhaustion	This was the first randomized study to investigate the efficacy of peripheral-blood progenitor cell (PBPC) mobilization using stem-cell factor (SCF) in combination with filgrastim (G-CSF) following chemotherapy compared with filgrastim alone following chemotherapy.	9704709
Stem Cell Factor	Stem Cell Exhaustion	In the apheresis product, threefold to fivefold increases in median CD34+ and progenitor cell yields were obtained in patients treated with SCF 20 microg/kg plus filgrastim compared with yields obtained in patients treated with filgrastim alone.	9704709
Stem Cell Factor	Stem Cell Exhaustion	SCF (15 or 20 microg/kg) in combination with filgrastim following chemotherapy is an effective way of increasing progenitor cell yields compared with filgrastim alone following chemotherapy.	9704709
Stem Cell Factor	Stem Cell Exhaustion	SCF in combination with filgrastim following chemotherapy enhanced the mobilization of progenitor cells compared with that produced by filgrastim alone following chemotherapy.	9704709
Chronic Lymphocytic Leukemia, Graft vs Leukemia Effect, Lymphoma	Stem Cell Exhaustion	To investigate the use of a nonmyeloablative fludarabine-based preparative regimen to produce sufficient immunosuppression to allow engraftment of allogeneic stem cells and induction of graft-versus-leukemia/lymphoma (GVL) as the primary treatment modality for patients with chronic lymphocytic leukemia (CLL) and lymphoma.	9704734
Malignant Neoplasms	Stem Cell Exhaustion	Transplant-lite: induction of graft-versus-malignancy using fludarabine-based nonablative chemotherapy and allogeneic blood progenitor-cell transplantation as treatment for lymphoid malignancies.	9704734
Cytomegalovirus Infections	Stem Cell Exhaustion	This trial was designed to compare foscarnet with ganciclovir as pre-emptive therapy for CMV infection in patients undergoing allogeneic hemopoietic stem cell transplant (HSCT).	9707026
Plasmodium vivax, Pancytopenia, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Plasmodium vivax causing pancytopenia after allogeneic blood stem cell transplantation in CML.	9707032
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	A 20-year-old male patient with chronic myeloid leukemia (CML), in chronic phase, underwent allogeneic blood stem cell transplantation in August 1996.	9707032
Cessation of life, Stem Cell Factor	Stem Cell Exhaustion	In addition we examined the in vitro effect of MGDF as well as the combined effect of MGDF and granulocyte colony-stimulating factor (G-CSF) or stem cell factor (SCF) on leukemic blast proliferation, recruitment into S-phase, induction of programmed cell death and activation of signal transducers and activators of transcription (STAT) proteins.	9711904
PAFAH1B1 wt Allele, Stem Cell Factor	Stem Cell Exhaustion	Furthermore, TPO increased the colony-stimulatory effects of G-CSF, GM-CSF, IL-3, and stem cell factor (SCF) on MDS marrow cells.	9713960
Childhood Breast Carcinoma	Stem Cell Exhaustion	Randomised trial of high-dose chemotherapy and haemopoietic progenitor-cell support in operable breast cancer with extensive axillary lymph-node involvement.	9716055
Cytotoxic (disposition)	Stem Cell Exhaustion	BB-10010 is a variant of the human form of macrophage inflammatory protein-1alpha (MIP-1alpha), which has been shown in mice to block the entry of hematopoietic stem cells into S-phase and to increase their self-renewal capacity during recovery from cytotoxic damage.	9716580
Peripheral Blood Stem Cells, Multiple Myeloma	Stem Cell Exhaustion	Phase I-II evaluation of rapid sequence tandem high-dose melphalan with peripheral blood stem cell support in patients with multiple myeloma.	9720737
Peripheral Blood Stem Cells, Multiple Myeloma	Stem Cell Exhaustion	This study was designed to determine the maximum tolerated dose (MTD) of high-dose melphalan (HDM), with peripheral blood stem cell support, that could be given twice within 90 days to patients with multiple myeloma.	9720737
Primary Myelofibrosis	Stem Cell Exhaustion	Myelofibrosis with myeloid metaplasia (MMM) is an uncommon disorder in young individuals, for whom haemopoietic stem cell transplantation offers the only possibility of cure.	9722294
leukemia	Stem Cell Exhaustion	These findings suggest FHIT gene involvement in the transformation of hematopoietic stem cells to leukemia.	9730598
Hematological Disease	Stem Cell Exhaustion	Seventeen patients with hematologic diseases had previously undergone high-dose chemotherapy and four stem cell transplantation.	9731021
Stem Cell Factor, Scleroderma	Stem Cell Exhaustion	As mast cells are increased in number in the lesional skin of the early stage of scleroderma, we addressed the question whether expression of stem cell factor (SCF), a mast cell growth factor, is upregulated in the lesional skin.	9732156
Specialty Type - cancer	Stem Cell Exhaustion	The importance of CD34+/CD33- cells in platelet engraftment after intensive therapy for cancer patients given peripheral blood stem cell rescue.	9733270
Specialty Type - cancer	Stem Cell Exhaustion	The study was designed to determine whether the number of CD34+/CD33- cells given at autologous peripheral blood stem cell (PBSC) rescue after intensive therapy for cancer was a better predictor of platelet engraftment than the total number of CD34+ cells infused.	9733270
Hyperplasia	Stem Cell Exhaustion	Prostate stem cell compartments: expression of the cell cycle inhibitor p27Kip1 in normal, hyperplastic, and neoplastic cells.	9736039
Benign prostatic hypertrophy	Stem Cell Exhaustion	The normal basal cell compartment, believed to contain prostatic stem cells, showed distinctive p27Kip1 expression; acini in epithelial benign prostatic hyperplasia tissue contained more p27Kip1-negative basal cells than acini from non-benign prostatic hyperplasia tissue.	9736039
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Stem cell factor enhances the adhesion of AML cells to fibronectin and augments fibronectin-mediated anti-apoptotic and proliferative signals.	9737685
Stem Cell Factor, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukaemia (AML) cells express the SCF receptor c-kit (CD117) on their cell surface and demonstrate enhanced adhesion to fibronectin (FN) following exposure to stem cell factor (SCF).	9737685
Multiple Myeloma	Stem Cell Exhaustion	Factors affecting both peripheral blood progenitor cell mobilization and hematopoietic recovery following autologous blood progenitor cell transplantation in multiple myeloma patients: a monocentric study.	9737695
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The aim of the study was to analyze the factors influencing peripheral blood progenitor cell (PBPC) collection after high-dose cyclophosphamide (HDCYC) (7 g/m2) and hematopoietic recovery after autologous transplantation of HDCYC-mobilized PBPC (ABPCT) in 116 patients with aggressive multiple myeloma (MM).	9737695
Lymphadenopathy, Sinus histiocytosis	Stem Cell Exhaustion	Sinus histiocytosis with massive lymphadenopathy is a non-neoplastic self-limiting disease of the bone marrow stem cell origin.	9741548
Childhood Breast Carcinoma	Stem Cell Exhaustion	The use of high-dose chemotherapy with stem cell support in early breast cancer is unjustified outside the clinical trial setting--current data indicate that such treatment may result in increased morbidity without a reduction in disease recurrence.	9741784
Neoplasms	Stem Cell Exhaustion	Evaluation of efficiency of bone marrow and peripheral stem cells transplantation in patients with solid tumors.	9742641
Malignant neoplasm of brain	Stem Cell Exhaustion	[High dose chemotherapy with thiotepa, carboplatin, VP16 and autologous stem cell transplantation in treatment of malignant brain tumors with poor prognosis.	9743961
Central visual impairment	Stem Cell Exhaustion	6 h, d-9), carboplatin and etoposide (500mg/m2/d, CVI 24h, d-8 to d-5, respectively) and was followed by the retransfusion of autologous blood stem cells on day 0.	9743961
Leukemia, Myelomonocytic, Chronic, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In the CMML patient and one AML (M2) patient with t(8;21), lymphoid and erythroid cells also showed the loss of chromosomes, suggesting that it should occur at stem-cell level.	9745772
Paroxysmal nocturnal hemoglobinuria, Hemolysis (biological function), Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal stem cell disorder characterized by complement-mediated hemolysis and deficient hematopoiesis.	9746796
Disorder of skeletal system	Stem Cell Exhaustion	It suggests the possible intervention of growth factors common to the skin fibroblasts and the blood progenitor cells in the pathogenesis of primary osteoarthropathy.	9747248
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	These observations also imply that CD7 expression on AML blasts may indicate involvement of leukaemic progenitors at an early stage of multipotent haemopoietic stem cells.	9753051
Malignant neoplasm of ovary	Stem Cell Exhaustion	[Mobilization of peripheral blood stem cells in advanced ovarian cancer].	9757199
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Relapsed chronic myeloid leukemia in accelerated phase 10 years after allogeneic bone marrow transplantation: full chimera reconversion with donor peripheral blood stem cells infusion.	9758351
Graft failure, Peripheral Stem Cell Transplantation, Lymphoma, Extramedullary Hematopoiesis Function	Stem Cell Exhaustion	We describe a 71-year-old man who, while receiving G-CSF for graft failure after peripheral blood stem cell transplant, developed dramatic extramedullary granulopoiesis that mimicked recurrent lymphoma.	9760159
PAFAH1B1 wt Allele, Cytopenia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is believed to be a stem-cell disorder involving cytopenia and dysplastic changes in three hematopoietic lineages.	9763574
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Fluorescence in situ hybridization of progenitor cells obtained by fluorescence-activated cell sorting for the detection of cells affected by chromosome abnormality trisomy 8 in patients with myelodysplastic syndromes.	9763574
Toxic effect	Stem Cell Exhaustion	High-dose etoposide with granulocyte colony-stimulating factor for mobilization of peripheral blood progenitor cells: efficacy and toxicity at three dose levels.	9764585
Toxic effect	Stem Cell Exhaustion	High-dose etoposide (2.0-2.4 g m(-2)) with granulocyte colony-stimulating factor (G-CSF) is an effective strategy to mobilize peripheral blood progenitor cells (PBPCs), although in some patients this is associated with significant toxicity.	9764585
Liver neoplasms, Stem cells	Stem Cell Exhaustion	Primary liver tumour of intermediate (hepatocyte-bile duct cell) phenotype: a progenitor cell tumour?	9766827
Neoplasms	Stem Cell Exhaustion	This type of tumour has not been described previously and provides additional evidence for the existence of progenitor cells in human liver.	9766827
Peripheral Blood Stem Cells, Juvenile granulosa cell tumor	Stem Cell Exhaustion	A 19-year-old woman with refractory juvenile granulosa cell tumors had persistent disease after PVB (cisplatin, vinblastine and bleomycin) and multiple high doses of ICE (ifosfamide, carboplatin and etoposide) with peripheral stem cell support.	9773806
Lupus Erythematosus	Stem Cell Exhaustion	Significance of stem cell factor and soluble KIT in patients with systemic lupus erythematosus.	9776111
Lupus Erythematosus, Systemic, Encephalitis, St. Louis, Stem Cell Factor	Stem Cell Exhaustion	To determine the significance of stem cell factor (SCF) and soluble KIT (sKIT) in the serum of patients with systemic lupus erythematosus (SLE), levels of SCF and sKIT in patients with SLE were estimated, and their correlations with clinical parameters were examined.	9776111
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Action of interleukin-3 on the proliferation of leukaemic progenitor cells from patients with acute myeloblastic leukaemia.	9777269
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In the present study, we examined the effects of interleukin-3 (IL-3) on the proliferation of leukaemic progenitor cells from 11 Japanese patients with acute myeloblastic leukaemia (AML), including the effect of its combination with granulocyte/macrophage colony-stimulating factor (GM-CSF) or granulocyte colony-stimulating factor (G-CSF).	9777269
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The results showed that IL-3 sufficiently stimulated the proliferation of AML progenitor cells in almost all the cases examined, and that the stimulation pattern of IL-3 was similar to that of GM-CSF, although different from that of G-CSF.	9777269
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	These findings suggest the possibility of IL-3/G-CSF/cytosine arabinoside (Ara-C) combination therapy, which may be able to enhance the cytotoxic effect of Ara-C on AML progenitor cells powerfully in a wider range of patients including cases refractory for IL-3/Ara-C combination therapy.	9777269
Multiple Myeloma	Stem Cell Exhaustion	High-dose therapy and autologous peripheral blood stem cell transplantation in multiple myeloma: up-front or rescue treatment?	9787148
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Results to date indicate that high-dose therapy (HDT) with autologous stem cell support improves survival of patients with symptomatic multiple myeloma (MM).	9787148
Hepatitis C, Hepatitis C, Chronic	Stem Cell Exhaustion	Hepatitis C virus infection involves CD34(+) hematopoietic progenitor cells in hepatitis C virus chronic carriers.	9787170
beta Thalassemia	Stem Cell Exhaustion	A program of cord blood stem cell (CBSC) transplants for patients with beta-thalassemia major was initiated in conjunction with the prenatal diagnostic service in 1994.	9787324
Pulmonary hemorrhage	Stem Cell Exhaustion	More intensive chemotherapy and allogenic peripheral blood stem cell transplantation were performed, but the infant died from pulmonary hemorrhage after the transplantation.	9787326
Neoplasms	Stem Cell Exhaustion	Although there were no objective tumor responses, we have demonstrated significant biologic activity with increased neutrophil and platelet counts, increased peripheral blood progenitor cells, and enhanced interferon-gamma-mediated MCCTX.	9789199
Hematologic Neoplasms	Stem Cell Exhaustion	Sixty-one patients who underwent either autologous bone marrow (BM; 28 patients) or peripheral blood stem cell (PBSC; 33 patients) transplantation for haematological malignancies were reviewed retrospectively.	9789217
Infection	Stem Cell Exhaustion	This study indicates that the use of peripheral blood stem cells results in faster engraftment and shorter hospital stay, whereas the effect on the incidence of early infections seems to be unaffected.	9789217
Seminoma, Choriocarcinoma	Stem Cell Exhaustion	A 44-year-old man received high-dose chemotherapy with carboplatin, etoposide and cyclophosphamide followed by autologous peripheral-blood stem-cell transplantation for treatment of refractory nonseminomatous testicular cancer (seminoma plus choriocarcinoma).	9793033
Autoimmune Diseases, Hereditary	Stem Cell Exhaustion	Immunoablation followed by allogeneic stem cell (SC) transplantation has been shown to be capable of curing a large spectrum of experimental autoimmune disorders, hereditary and/or induced.	9796853
Autoimmune Diseases	Stem Cell Exhaustion	Case reports are being collected in the registry of the European Group for Blood and Marrow Transplantation (EBMT)/European League against Rheumatism (EULAR) Autoimmune Disease Stem Cell Project.	9796853
Merkel cell carcinoma, Squamous cell carcinoma	Stem Cell Exhaustion	The intimate admixture of the 2 antigenically different neoplastic cell types, and common etiologic role of ultraviolet and possibly infrared damage, lend support to the theory that some Merkel cell carcinomas and squamous cell carcinomas may arise from a pluripotent epidermal stem cell.	9810922
Myelosuppression	Stem Cell Exhaustion	Administration of growth factors prior to chemotherapy (priming) may reduce myelosuppression and provide an alternative to the use of stem cell support for the delivery of dose-intensive therapy.	9815838
Agenesis	Stem Cell Exhaustion	It is possible, however, that such priming may worsen aplasia, either by recruitment of progenitors into cell cycle and thereby increasing their sensitivity to chemotherapy or by depleting stem cell pools.	9815838
Malignant Head and Neck Neoplasm	Stem Cell Exhaustion	The purpose of this study was to determine if human head and neck cancers secrete GM-CSF, if this is associated with an intratumoral presence of similar cells expressing the hematopoietic progenitor cell antigen CD34, and if such CD34(+) cells suppress functions of intratumoral T cells.	9815891
Malignant Neoplasms	Stem Cell Exhaustion	Each of the high GM-CSF-secreting SCCs, but none of the cancers that did not secrete GM-CSF, contained cells expressing the hematopoietic progenitor cell antigen CD34 that had the capacity to grow into colonies in soft agar.	9815891
Neoplasms	Stem Cell Exhaustion	Production of granulocyte-macrophage colony-stimulating factor (GM-CSF) by murine tumors has been shown to induce immune suppressive cells having homology with GM progenitor cells.	9815891
Failure, Childhood Breast Carcinoma, Lymphoma	Stem Cell Exhaustion	Relapse after high-dose chemotherapy supported by peripheral blood stem cell transplantation (HDC-PBSCT) is the main cause of therapeutic failure in patients with lymphoma and breast cancer.	9816022
Toxic effect	Stem Cell Exhaustion	Overall toxicity associated with early posttransplant transfer of A-NK cells and interleukin 2 did not differ from that observed with peripheral blood stem cell transplantation alone in comparable patients.	9816022
Toxic effect	Stem Cell Exhaustion	It can be escalated without excessive toxicity to 200 mg/m2, a myeloablative dose requiring hematopoietic stem cell support.	9816255
Kidney Failure, Gastrointestinal mucositis	Stem Cell Exhaustion	Renal insufficiency also had no apparent negative impact on the quality of peripheral blood stem cell collections and did not adversely affect posttransplant engraftment, transfusion requirements, incidence of severe mucositis, or overall survival.	9816255
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	In vitro stimulation of erythropoiesis by stem cell factor alone in myelodysplastic syndrome patients with elevated endogenous erythropoietin serum levels.	9816264
Anemia, PAFAH1B1 wt Allele, Stem Cell Factor	Stem Cell Exhaustion	In view of the recently reported potential of stem cell factor (SCF) in restoring erythropoiesis in combination with erythropoietin (Epo), we first aimed to define a correlation between SCF serum levels and anemia in MDS.	9816264
Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	Occult tumor contamination of hematopoietic stem-cell products does not affect clinical outcome of autologous transplantation in patients with metastatic breast cancer.	9817268
Childhood Breast Carcinoma	Stem Cell Exhaustion	Three patients who received stem-cell products contaminated by microscopic breast cancer remain free from progression at 21+, 47+, and 52+ months.	9817268
Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	Microscopic tumor was frequently detected by immunocytochemistry in hematopoietic stem-cell products, but did not predict for inferior treatment outcome in this cohort of patients with metastatic breast cancer.	9817268
Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	To determine whether occult tumor contamination of autologous bone marrow or peripheral-blood progenitor cells (PBPC) influences clinical outcome after high-dose chemotherapy in patients with stage IV breast cancer.	9817268
Aspergillus ustus, Aspergillosis	Stem Cell Exhaustion	Disseminated aspergillosis caused by Aspergillus ustus in a patient following allogeneic peripheral stem cell transplantation.	9817905
Aspergillus ustus, Aspergillosis	Stem Cell Exhaustion	The first case of disseminated aspergillosis caused by Aspergillus ustus in an allogeneic peripheral stem cell transplant patient is described.	9817905
Lymphoma, Non-Hodgkin, Glomerulonephritis	Stem Cell Exhaustion	Crescentic glomerulonephritis developing 3 months after autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma.	9818704
Multiple Myeloma	Stem Cell Exhaustion	A 35-year-old woman diagnosed with multiple myeloma (IgG, lambda type, stage IIIA) received an autologous peripheral blood stem cell transplant (PBSCT).	9818705
PAFAH1B1 wt Allele	Stem Cell Exhaustion	The coexpression of CD3 and CD7 with markers of the myeloid lineage may reflect derangement of the differentiation of pluripotent stem cells characteristic for MDS.	9819667
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are highly proliferative bone marrow (BM) disorders where the primary lesion presumably affects a CD34+ early progenitor or stem cell.	9823942
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation as salvage treatment for advanced B cell chronic lymphocytic leukemia.	9823944
Hematologic Neoplasms	Stem Cell Exhaustion	Factors influencing haemopoietic recovery following chemotherapy-mobilised autologous peripheral blood progenitor cell transplantation for haematological malignancies: a retrospective analysis of a 10-year single institution experience.	9827973
Thrombocytopenic purpura	Stem Cell Exhaustion	Failure of autologous stem cell transplantation in refractory thrombocytopenic purpura.	9827985
Failure	Stem Cell Exhaustion	This is the fourth case in the literature to show failure following autologous stem cell transplantation, although complete, steroid-independent remissions were obtained in the first two patients for over 1 year.	9827985
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myeloid leukemia (CML) is thought to arise from a pluripotent hematopoietic stem cell that has undergone a reciprocal translocation between the BCR gene on chromosome 22 and the ABL proto-oncogene on chromosome 9.	9845542
Mastocytosis	Stem Cell Exhaustion	In contrast to FISH of blood and bone marrow, which gives information principally about mature cells, the technique of "sorter FISH (FACS + FISH)" provides a powerful tool to explore the cytogenetic changes in immature cell populations of stem cell diseases based on immunophenotypes.	9845542
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Lineage involvement of stem cells bearing the philadelphia chromosome in chronic myeloid leukemia in the chronic phase as shown by a combination of fluorescence-activated cell sorting and fluorescence in situ hybridization.	9845542
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	To examine this issue, we combined fluorescence-activated cell sorting (FACS) and fluorescence in situ hybridization (FISH) to study lineage involvement of mature cells and stem cells in 12 patients with CML in the chronic phase.	9845542
HIV	Stem Cell Exhaustion	Although initially described as a pro-inflammatory cytokine, it is now recognised that hMIP-1 alpha has additional effects on haemopoietic stem cell cycling and on human immunodeficiency virus uptake by macrophages.	9849450
Graft-vs-Host Disease, Hematologic Neoplasms	Stem Cell Exhaustion	CD34+ stem cell augmentation of elutriated allogeneic bone marrow grafts: results of a phase II clinical trial of engraftment and graft-versus-host disease prophylaxis in high-risk hematologic malignancies.	9849691
Hematologic Neoplasms	Stem Cell Exhaustion	In order to determine if the discarded CD34+ cells would improve engraftment, we undertook a phase II trial of allogeneic BMT in which 110 patients (median age 43) with a variety of hematologic malignancies received CD34+ stem cell augmented, elutriated marrow grafts.	9849691
Hemorrhagic cystitis	Stem Cell Exhaustion	Late-onset hemorrhagic cystitis after hematopoietic stem cell transplantation in children.	9849697
CLTC gene, Hemorrhagic cystitis	Stem Cell Exhaustion	We analyzed the incidence, complications, and risk factors for late-onset hemorrhagic cystitis (HC) in 256 children undergoing hematopoietic stem cell transplantation (HSCT).	9849697
Multiple Organ Failure	Stem Cell Exhaustion	Increased platelet transfusion requirement is associated with multiple organ dysfunctions in patients undergoing hematopoietic stem cell transplantation.	9849698
Organ Dysfunction Scores	Stem Cell Exhaustion	Organ dysfunction following hematopoietic stem cell transplantation (HSCT) may be a manifestation of a systemic inflammatory response.	9849698
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Stem Cell Exhaustion	Hyper-CVAD and high-dose methotrexate/cytarabine followed by stem-cell transplantation: an active regimen for aggressive mantle-cell lymphoma.	9850025
Medial collateral ligament	Stem Cell Exhaustion	The Hyper-CVAD/MTX-Ara-C program followed by stem-cell transplantation is a promising new therapy for previously untreated patients with MCL.	9850025
Malignant Neoplasms	Stem Cell Exhaustion	Although absent in most adult somatic tissues, telomerase activity is present in stem cells and is reactivated in nearly all primary human malignancies.	9854593
Degenerative polyarthritis, Idiopathic osteoarthritis	Stem Cell Exhaustion	The variation in marrow colony forming unit-fibroblastic (CFU-F) number in 59 patients (14-87 years of age) undergoing corrective surgery (14 controls; 14-48 years of age) or hip arthroplasty for primary osteoarthritis (45 OA; 46-87 years of age) was examined to determine whether marrow CFU-F, derived from marrow stromal fibroblastic stem cells, are maintained with the development of primary osteoarthritis (OA).	9855211
Degenerative polyarthritis, Deficit	Stem Cell Exhaustion	As there is no apparent deficit in primitive progenitor cells, this preservation may be the result of altered regulation of osteoprogenitor activity in OA.	9855211
Inflammation, Arthritis, Stem Cell Factor	Stem Cell Exhaustion	Expression of stem cell factor (SCF) and SCF receptor (c-kit) in synovial membrane in arthritis: correlation with synovial mast cell hyperplasia and inflammation.	9858422
Stem Cell Factor	Stem Cell Exhaustion	Stem cell factor (SCF), the ligand for the SCF receptor (c-kit) expressed on precursors and mature mast cells (MC), is a major agonist for human MC (e.g., SCF induces MC development, chemotaxis, activation, proliferation of MC precursors, mediates MC adhesion, and changes MC releasability).	9858422
Peripheral Stem Cell Transplantation, Neoplasms	Stem Cell Exhaustion	Recently high-dose chemotherapy with peripheral blood stem cell transplantation (PBSCT) has become an important treatment for hematological and solid tumors.	9860293
Malignant neoplasm of lung, Lymphoma	Stem Cell Exhaustion	The transfused peripheral stem cells of lung cancer and lymphoma patients had a similar number of granulocyte/macrophage-colony-forming units, but lung cancer patients had significantly more CD34-positive cells.	9860293
Pancytopenia, Aplastic Anemia	Stem Cell Exhaustion	Aplastic anaemia is a relatively rare disease, characterized by the loss of haemopoietic "stem" cells in the bone marrow, exchanged with fat cells and pancytopenia.	9863388
Peripheral Blood Stem Cells	Stem Cell Exhaustion	Thus, age is not a biologically adverse parameter for patients with MM receiving high-dose melphalan-based therapy with peripheral blood stem cell support and, hence, should not constitute an exclusion criterion for participation in what appears to be superior therapy for symptomatic MM.	9864145
Harvesting of peripheral blood stem cells	Stem Cell Exhaustion	Remission induction utilized non-cross-resistant regimens (vincristine-doxorubicin-dexamethasone [VAD], high-dose cyclophosphamide and granulocyte-macrophage colony-stimulating factor with peripheral blood stem cell collection, and etoposide-dexamethasone-cytarabine-cisplatin).	9864146
Adenomatous Polyposis Coli	Stem Cell Exhaustion	Increased stem cell somatic mutation in the non-neoplastic colorectal mucosa of patients with familial adenomatous polyposis.	9865843
MLH1 protein, human, Crohn Disease, Hereditary Nonpolyposis Colorectal Cancer, FAP protein, human	Stem Cell Exhaustion	We aimed to quantify stem cell somatic mutation in FAP, comparing it with hereditary nonpolyposis colorectal cancer (HNPCC) and Crohn's disease (CD).	9865843
MLH1 protein, human, FAP protein, human	Stem Cell Exhaustion	Stem cell somatic mutation frequency was studied in 47 FAP patients, 5 HNPCC patients, and 13 CD patients, all younger than 49 years, by quantifying crypt-restricted loss of O-acetyltransferase activity in sections of morphologically normal colonic mucosa from individuals heterozygous for this monogenically inherited polymorphism.	9865843
MLH1 protein, human, FAP protein, human	Stem Cell Exhaustion	Median stem cell somatic mutation frequency was significantly higher in FAP than HNPCC (4.2 x 10(-4) v 1.4 x 10(-4), Mann-Whitney U, P < .02).	9865843
MLH1 protein, human, FAP protein, human	Stem Cell Exhaustion	Mutated crypts occurred in groups more frequently in FAP (22%) than HNPCC (12%) or CD (10%), suggesting an increase in stem cell division associated with crypt fission in FAP.	9865843
FAP protein, human	Stem Cell Exhaustion	We conclude that stem cell somatic mutation frequency is raised in non-neoplastic colorectal mucosa in FAP.	9865843
Neoplasms	Stem Cell Exhaustion	This is probably related to increased stem cell proliferation and contributes to the high rate of tumor formation in this condition.	9865843
Hematological Disease	Stem Cell Exhaustion	[Allogeneic peripheral blood stem cell transplantation in 30 patients with hematologic disorders].	9866419
Acute lymphocytic leukemia, Hematological Disease, Myeloid Leukemia, Chronic, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Thirty patients (median age of 32 years; range, 6-61) with hematologic disorders received unmanipulated peripheral blood stem cell transplants from HLA-matched or one-antigen-mismatched related donors following myeloablative therapy for acute lymphoblastic leukemia (7), acute myelogenous leukemia (6), chronic myelogenous leukemia (8), myelodysplastic syndrome (3), or other disorders (6).	9866419
Burkitt Lymphoma, Central Nervous System Involvement	Stem Cell Exhaustion	[Successful treatment with high dose chemotherapy following peripheral blood stem cell transplantation for relapsed Burkitt's lymphoma with central nervous system involvement].	9866425
Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	Chemotherapy combined with peripheral blood stem cell transplantation reduced the size of the tumor significantly.	9866983
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Low-dose total body irradiation and G-CSF without hematopoietic stem cell support in the treatment of relapsed or refractory acute myelogenous leukemia (AML), or AML in second or subsequent remission.	9869237
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Total body irradiation (TBI) is an effective modality against AML when used in doses of 1000-1400 cGy with hematopoietic stem cell support.	9869237
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We undertook a phase I study of TBI with granulocyte-colony-stimulating factor (G-CSF) support, without stem cell support in patients with AML either in relapse or second or subsequent remission.	9869237
Traumatic Brain Injury	Stem Cell Exhaustion	If TBI is to be escalated without stem cell support, then a thrombopoietic agent will need to be used.	9869237
Merkel cell carcinoma	Stem Cell Exhaustion	We believe that this is probably the most convincing case of intraepidermal Merkel cell carcinoma originating from epidermal Merkel cells or its precursors (stem cells).	9870679
Neoplasms	Stem Cell Exhaustion	The neoplasia likely results, in part, from deregulated cell proliferation, which allows mutations to become fixed in the crypt progenitor cells.	9872652
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The frequent lineage infidelity of the blast cells in CML BT seems to be related to the stem cell origin of this disorder.	9872654
Colorectal Carcinoma	Stem Cell Exhaustion	No difference in stem cell somatic mutation between the background mucosa of right- and left-sided sporadic colorectal carcinomas.	9875137
Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	No significant difference was found between the frequencies of wholly involved mPAS-positive crypts in background mucosa of left- and right-sided cancers (p = 0.4569), indicating that tumours on both sides of the colon are associated with similar levels of lifetime-accumulated stem cell mutational load.	9875137
Malignant tumor of colon, Carcinoma	Stem Cell Exhaustion	The findings indicate that although left-sided colonic cancer is commoner than right-sided cancer in the British population, carcinomas on both sides of the large bowel arise in a background of similar levels of stem cell mutational activity.	9875137
Pancreatitis	Stem Cell Exhaustion	This investigation has shown that loss of parenchymal epithelium occurring in chronic pancreatitis is not caused by a primary failure of pancreatic 'stem-cell' proliferation, but is due to disproportionate attrition of differentiated parenchymal epithelial cells by a mechanism, possibly stromal in origin, which remains hitherto unidentified.	9875147
Chronic calcifying pancreatitis	Stem Cell Exhaustion	Preservation of 'stem-cell' function supports the belief that regeneration of pancreatic parenchymal tissue could be a feasible proposition if biologically appropriate management strategies were developed to treat chronic calcifying pancreatitis.	9875147
Graft-vs-Host Disease, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Graft-versus-host disease following second syngeneic stem cell transplantation for relapsed chronic myeloid leukemia.	9875666
B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1	Stem Cell Exhaustion	We investigated an intensified conditioning regimen including fractionated total body irradiation (12 Gy), etoposide (30-45 mg/kg) and cyclophosphamide (120 mg/kg), followed by autologous (n = 5), allo-related (n = 13) or allo-unrelated (n = 6) bone marrow (n = 22) or peripheral stem cell (n = 2) transplantation in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.	9877263
Decreased platelet count	Stem Cell Exhaustion	Prolonged isolated thrombocytopenia after hematopoietic stem cell transplantation: morphologic correlation.	9877269
Decreased platelet count	Stem Cell Exhaustion	Prolonged isolated thrombocytopenia, defined as recovery of other cell counts with continuous dependence on platelet transfusions for greater than 90 days after hematopoietic stem cell transplantation (HSCT), develops in approximately 5% of patients who undergo HSCT.	9877269
Decreased platelet count	Stem Cell Exhaustion	Patients (aged 1-56 years, mean 32 years) who underwent HSCT (four sibling HLA-identical, five autologous bone marrow, three autologous peripheral stem cell) with prolonged isolated thrombocytopenia had a statistically significant lower absolute megakaryocyte count in bone marrow biopsies performed before transplantation and more than 30 days after transplantation compared to control patients (aged 4 months to 50 years, mean 31 years) who underwent HSCT (four sibling HLA-identical, four autologous bone marrow, four autologous peripheral stem cell) for similar conditions.	9877269
Destruction (action), Hemopoietic stem cell transplant, Decreased platelet count	Stem Cell Exhaustion	These findings suggest that decreased differentiation of megakaryocytes from stem cells, rather than ineffective platelet production or peripheral destruction of platelets, causes prolonged isolated thrombocytopenia in HSCT patients.	9877269
neurological complication	Stem Cell Exhaustion	Neurological complications after autologous stem cell transplantation.	9885329
Hematologic Neoplasms, Neoplasms	Stem Cell Exhaustion	Autologous bone marrow (BMT) or peripheral blood stem cell transplantation (PBSCT) are increasingly used to treat hematological malignancies and solid tumors.	9885329
Neutropenia	Stem Cell Exhaustion	Colony-stimulating factors (CSFs) are commonly used for the treatment of neutropenia following chemotherapy and for the mobilization of peripheral blood stem cells (PBSC).	9886182
Myeloproliferative disease, MVD gene, Myeloid	Stem Cell Exhaustion	The myeloproliferative disorders (MPD) are clonal diseases that originate from a transformed stem cell and involve all myeloid lineage.	9887281
T-Cell Lymphoma	Stem Cell Exhaustion	Recurrence with histological transformation 40 days after autologous peripheral blood stem cell transplantation (APBSCT) for cutaneous CD30-negative large T cell lymphoma.	9894726
T-Cell Lymphoma	Stem Cell Exhaustion	As the clinical course of CD30-negative cutaneous large T cell lymphoma is recurrent and often incurable with conventional chemoradiotherapy, she received high-dose chemotherapy without total body irradiation (TBI) followed by unpurged autologous peripheral blood stem cell transplantation (APBSCT).	9894726
Traumatic Brain Injury, Lymphoma	Stem Cell Exhaustion	We question the need for TBI in conditioning and for purged stem cells for APBSCT in patients with high risk cutaneous lymphomas.	9894726
Childhood Breast Carcinoma	Stem Cell Exhaustion	A randomized trial of recombinant human interleukin-11 following autologous bone marrow transplantation with peripheral blood progenitor cell support in patients with breast cancer.	9923411
Childhood Breast Carcinoma	Stem Cell Exhaustion	This study assessed the safety and efficacy of recombinant human interleukin (rhIL)-11 in decreasing platelet transfusion requirements in patients with breast cancer who were undergoing autologous bone marrow transplantation (ABMT) with peripheral blood progenitor cell (PBPC) support.	9923411
Positive Lymph Node	Stem Cell Exhaustion	Present activities include a study in premenopausal patients with node-positive, receptor-positive disease (CMF vs castration), a study in pre- and postmenopausal patients with node-positive, receptor-negative disease (CMF vs CEF), and a study in high-risk patients aged < 60 years (dose-escalating CEF vs three cycles of CEF followed by high-dose chemotherapy and autologous stem cell support).	9928578
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Recombinant human hematopoietic growth factors are widely used in the treatment of multiple myeloma (MM) especially due to the increasing role of autologous blood stem cell transplantation (ABSCT).	9929931
Lymphoma, Follicular	Stem Cell Exhaustion	Allogeneic peripheral blood stem cell transplantation for the treatment of refractory follicular lymphoma.	9932640
Neoplasms	Stem Cell Exhaustion	The production of Bcl-2 protein by tumor cells and tumor-neighboring crypt cells indicates that the bcl-2 protooncogene may act not only as an inhibitor of apoptosis but also as an inducer of neuroendocrine differentiation from the latent characteristics of the endodermal stem cell.	9987648
Osteosarcoma	Stem Cell Exhaustion	Feasibility of high-dose chemotherapy and autologous peripheral blood stem cell transplantation in children with high grade osteosarcoma.	9989888
Osteosarcoma	Stem Cell Exhaustion	An Italian-Scandinavian treatment and research protocol with high-dose chemotherapy and double peripheral blood stem cell (PBSC) transplantation has been designed in an attempt to improve overall results of children with metastatic osteosarcoma (OST).	9989888
Neoplasms	Stem Cell Exhaustion	To overcome this multiple-drug resistance of the tumor cells, cyclosporine and high-dose chemotherapy was combined with peripheral-blood stem-cell transplantation.	10025761
Alopecia, Folliculitis	Stem Cell Exhaustion	Diffuse alopecia with stem cell folliculitis: chronic diffuse alopecia areata or a distinct entity?	10027527
Folliculitis, Androgenetic Alopecia	Stem Cell Exhaustion	I speculate whether these findings may represent a stem cell folliculitis similar to the reaction pattern previously observed in graft versus host disease and in androgenetic alopecia.	10027527
Alopecia, Inflammation	Stem Cell Exhaustion	The clinical presentation of a slowly progressive diffuse alopecia without progression to clinically recognizable alopecia areata and the prominent lymphocytic inflammation involving the stem cell compartment may prompt a reexamination of similar cases currently classified as chronic diffuse alopecia areata.	10027527
Mass of abdominal cavity structure	Stem Cell Exhaustion	[Chemotherapy-resistant CD7-positive stem cell lymphoma presenting with intra-abdominal mass].	10028852
Malignant lymphoma, stem cell type	Stem Cell Exhaustion	We report a case of CD7+ stem cell lymphoma.	10028852
Peripheral Blood Stem Cells, Killer Cells	Stem Cell Exhaustion	High-dose chemotherapy with peripheral blood stem cell rescue in blastoid natural killer cell lymphoma.	10048432
Peripheral Blood Stem Cells	Stem Cell Exhaustion	We consider that blastoid NK cell lymphoma is an extremely aggressive subtype of CD56-positive lymphomas, and high-dose chemotherapy with peripheral blood stem cell rescue should be included for the choice of the treatment.	10048432
Anemia, Refractory anemia with ringed sideroblasts, Sideroblast	Stem Cell Exhaustion	In the present study, the clonal relationship was investigated between peripheral blood polymorphonuclear cells (PMNCs) and marrow progenitor cells and the origin of ringed sideroblasts in patients with refractory anemia with ring sideroblasts (RARS) by polymerase chain reaction (PCR) of HUMARA gene.	10049048
Refractory anemia with ringed sideroblasts, Sideroblast	Stem Cell Exhaustion	Our findings suggest that non-clonal progenitor cells persist in some RARS cases, that erythroid progenitors show mosaicism, and that ringed sideroblasts may be derived from an abnormal clone involved in the pathogenesis of this disease.	10049048
FLT3 protein, human, Hematological Disease	Stem Cell Exhaustion	Flt-3 ligand (FL) is a growth factor (GF) which might have clinical use as a mobilizer of stem and progenitor cells into peripheral blood (PB) in autologous transplantations of various malignant haematological diseases, unless FL stimulates the growth of malignant cells in these diseases.	10052713
Chronic myeloproliferative disorder, DPM1 gene	Stem Cell Exhaustion	The present study evaluated the effects of FL on the proliferation of granulocytemacrophage (GM) progenitor cells collected from PB of 24 patients with chronic myeloproliferative disorders (MPDs) by using a methylcellulose assay in serum-free culture conditions.	10052713
Primary Myelofibrosis, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	[Allogeneic peripheral blood stem cell transplantation in an elderly patient with myelodysplatic syndrome with myelofibrosis].	10067093
Graft-vs-Host Disease	Stem Cell Exhaustion	Allogeneic peripheral blood stem cell transplantation (Allo-PBSCT) has in recent years become an alternative to allogeneic bone marrow transplantation because it facilitates rapid hematopoietic reconstitution without an increase in the incidence of severe graft-versus-host disease (GVHD).	10067093
Pure Red-Cell Aplasia, Myeloproliferative disease, PAFAH1B1 wt Allele	Stem Cell Exhaustion	These findings suggested that a common deranged stem cell was the origin of 3 different states; PRCA, chromic myeloproliferative disorder, and MDS.	10067094
Neoplasms	Stem Cell Exhaustion	Enrichment for stem cells using anti-CD34 antibodies has been shown to reduce autograft tumor contamination in phase I/II studies.	10068658
Multiple Myeloma	Stem Cell Exhaustion	Multicenter phase III trial to evaluate CD34(+) selected versus unselected autologous peripheral blood progenitor cell transplantation in multiple myeloma.	10068658
Multiple Myeloma	Stem Cell Exhaustion	To more definitively assess the safety and efficacy of CD34 selection, a phase III study was completed in 131 multiple myeloma patients randomized to receive an autologous transplant with either CD34-selected or unselected peripheral blood progenitor cells after myeloablative therapy.	10068658
Neoplasms	Stem Cell Exhaustion	In conclusion, this phase III trial demonstrates that CD34-selection of peripheral blood progenitor cells significantly reduces tumor cell contamination yet provides safe and rapid hematologic recovery for patients receiving myeloablative therapy.	10068658
Chronic graft-versus-host disease, Scleroderma	Stem Cell Exhaustion	Scleroderma has a peak incidence in women after childbearing years and has clinical similarities to chronic graft-versus-host disease that occurs after allogeneic hematopoietic stem-cell transplantation, known to involve chimerism.	10068676
Graft-vs-Host Disease	Stem Cell Exhaustion	Preventing graft-versus-host disease (GVHD) by depletion of T lymphocytes from the stem cell graft for transplantation remains controversial, mainly because of the perceived increase in disease recurrence.	10071037
Febrile Neutropenia, Pneumonia	Stem Cell Exhaustion	Pneumonia in febrile neutropenic patients and in bone marrow and blood stem-cell transplant recipients: use of high-resolution computed tomography.	10071269
Multiple Myeloma	Stem Cell Exhaustion	In this study, stem cells were collected within 6 months of diagnosis, followed by transplantation only at progression of myeloma.	10084252
Multiple Myeloma	Stem Cell Exhaustion	One hundred and eighteen patients with multiple myeloma had stem cells collected and cryopreserved.	10084252
Multiple Myeloma	Stem Cell Exhaustion	We conclude that early cryopreservation of blood stem cells followed by transplantation at progression is a feasible approach to therapy in patients with myeloma.	10084252
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Furthermore, WT1 expression in PB of patients with overt AML evolved from MDS was significantly decreased by effective chemotherapy or allogeneic stem cell transplantation and became undetectable in long-term survivors.	10086730
Multiple Myeloma	Stem Cell Exhaustion	Linear reduction of clonal cells in stem cell enriched grafts in transplanted multiple myeloma.	10086793
Peripheral Stem Cell Transplantation, Multiple Myeloma	Stem Cell Exhaustion	In 30 patients with multiple myeloma who were scheduled for peripheral blood stem-cell transplantation, a quantitative analysis of the stem cells following enrichment by anti-CD34 was carried out.	10086793
Multiple Myeloma	Stem Cell Exhaustion	The stem-cell selection reduced the median concentration of clonal cells per million total cells by half, with a highly significant linear relationship between the number of myeloma cells before and after stem cell enrichment.	10086793
Amyloidosis	Stem Cell Exhaustion	Intermediate-dose intravenous melphalan and blood stem cells mobilized with sequential GM+G-CSF or G-CSF alone to treat AL (amyloid light chain) amyloidosis.	10086794
Amyloidosis	Stem Cell Exhaustion	AL amyloidosis patients ineligible for dose-intensive melphalan (200 mg/m2) were enrolled on a phase 11 trial to be treated with two cycles of intermediate-dose melphalan (IDM 100 mg/m2) and mobilized blood stem cells (BSC).	10086794
Peripheral Blood Stem Cells, Trophoblastic Neoplasms	Stem Cell Exhaustion	Failure of high-dose chemotherapy with peripheral blood stem cell support for refractory placental site trophoblastic tumor.	10087421
Splenic Rupture, Peripheral Blood Stem Cells, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Splenic rupture in a patient with acute myeloid leukemia undergoing peripheral blood stem cell transplantation.	10089026
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Here, we present the case of a 22-year-old woman with the diagnosis of acute myeloid leukemia who was undergoing peripheral blood stem cell transplantation.	10089026
Peripheral Stem Cell Transplantation, Rupture	Stem Cell Exhaustion	This is the first report of splenic rupture during peripheral blood stem cell transplantation.	10089026
Fibrosis Assessment, Primary Myelofibrosis	Stem Cell Exhaustion	Circulating haemopoietic progenitor cells in primary and secondary myelofibrosis: relation to collagen and reticulin fibrosis.	10089892
Fibrosis Assessment, Primary Myelofibrosis	Stem Cell Exhaustion	The relationship between the extent of bone marrow reticulin and collagen fibrosis and the concentration of granulocytic (CFU-GM), erythroid (BFU-E) and megakaryocyte (CFU-Mk) progenitor cells in the peripheral blood of patients with primary agnogenic myeloid metaplasia (AMM) and secondary myelofibrosis (sMF) has not been definitively correlated.	10089892
Congenital MeSH qualifier, Dermoid Cyst	Stem Cell Exhaustion	Dermoid cysts are congenital lesions deriving from the ectodermal differentiation of stem cells.	10091357
Lymphoma	Stem Cell Exhaustion	Costs of high-dose salvage therapy and blood stem cell transplantation for resistant-relapsed malignant lymphomas in a southern Italian hospital.	10091413
Lymphoma	Stem Cell Exhaustion	Analysis of costs of high technological procedures such as peripheral blood stem cell (PBSC) autotransplantation in lymphomas are generally finalized at disclosing whether the improvement of survival in a subset of patients is cost effective and whether the cost of the procedure could be reduced.	10091413
Stem Cell Factor	Stem Cell Exhaustion	Marked up-regulation of growth factors, cytokines and receptor expression was observed in thick (> 1 mm) primary melanomas, which were stained with polyclonal or monoclonal antibodies (MAbs) for IL-1alpha, IL-1beta, IL-6, IL-8, TNF-alpha, TGF-beta, granulocyte-macrophage colony-stimulating factor (GMCSF) and stem cell factor (SCF), but not IL-2.	10096249
Varicella Zoster Virus Infection	Stem Cell Exhaustion	Varicella zoster virus infection associated with high-dose chemotherapy and autologous stem-cell rescue.	10100561
varicella zoster, herpesvirus 3, human, Communicable Diseases	Stem Cell Exhaustion	A retrospective evaluation of 215 consecutive recipients of high-dose chemotherapy (HDC) and autologous stem cell rescue (ASCR) was conducted to ascertain the incidence, temporal course, and outcome of varicella zoster virus (VZV) infection.	10100561
Immunologic Deficiency Syndromes	Stem Cell Exhaustion	Successful human umbilical cord blood stem cell transplantation without conditioning in severe combined immune deficiency.	10100587
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Allogeneic haematopoietic stem cell transplantation (HSCT) was considered until recently as the only curative approach for MDS.	10101211
Inferior vena cava structure	Stem Cell Exhaustion	Double-lumen inferior vena cava catheters for peripheral stem cell apheresis and transplantations.	10155708
Neoplasms, Skin Basal Cell Carcinoma	Stem Cell Exhaustion	Because the best evidence suggests that basal cell carcinomas arise from primitive stem cells that differentiate along follicular lines, it is not uncommon that this tumor may resemble and be confused with a variety of benign and malignant follicular and sweat gland tumors.	10188838
Specialty Type - cancer	Stem Cell Exhaustion	Peripheral blood progenitor cell collections in cancer patients: analysis of factors affecting the yields.	10190949
Malignant Neoplasms	Stem Cell Exhaustion	Peripheral blood progenitor cells (PBPC) are now widely used to restore hematopoiesis following high dose chemotherapy in patients with malignancies.	10190949
Lymphoma, Follicular	Stem Cell Exhaustion	Autologous stem cell transplantation in advanced follicular lymphoma.	10190950
Hematologic Neoplasms	Stem Cell Exhaustion	We examined the effect of IL-2 incubation on progenitor cells from 24 patients with hematologic malignancies using paired autologous bone marrow (ABM) and PBSC to determine differences in hematopoietic potential.	10192300
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	A prospective study of risk-adapted therapy for large cell non-Hodgkin's lymphoma with VACOP-B followed by high-dose CBV and autologous progenitor cell transplantation for high-risk patients in remission.	10192438
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Several centres reported a favourable outcome after high-dose chemotherapy with autologous progenitor cell transplantation in selected patients with high-risk large cell non-Hodgkin's lymphoma in first remission.	10192438
Neoplasms	Stem Cell Exhaustion	To identify the developmental stage of the tumor progenitor cells, we micromanipulated the putative neoplastic large CD20(+) cells from TCRBCLs and amplified and sequenced immunoglobulin (Ig) V gene rearrangements from individual cells.	10194448
Lymphoma, leukemia	Stem Cell Exhaustion	Fludarabine-based non-myeloablative chemotherapy followed by infusion of HLA-identical stem cells for relapsed leukaemia and lymphoma.	10197793
Abnormality of blood and blood-forming tissues, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative, Gammopathy	Stem Cell Exhaustion	It seems likely and interesting that the coexistent monoclonal gammopathy and aCML might have arisen from common abnormal hematopoietic stem cells.	10199207
REG1CP gene	Stem Cell Exhaustion	Recently, a number of RS cells have been found to express an antigen that is also present on follicular dendritic cells (FDCs), asserting FDCs as the possible progenitor cells of H-RS cells.	10199466
Neoplasms, Tetranitromethane, Nested Diagnostic Context	Stem Cell Exhaustion	For univariate analysis, 17 factors were studied, including age, sex, TNM stage, diameter of the tumor, pleural involvement, degree of differentiation, scar grade, nuclear atypia, mitotic index, histogram pattern of NDC, mean NDC, number of aneuploid stem cell lines, and mean and SD of NA.	10208203
Nested Diagnostic Context, Tetranitromethane	Stem Cell Exhaustion	In the univariate analysis, 12 factors were significantly related to postoperative survival, including TNM stage, diameter, pleural involvement, nuclear atypia, mitotic index, mean NA, mean NDC, number of aneuploid stem cell lines, and the DNA histogram pattern.	10208203
Systemic Scleroderma	Stem Cell Exhaustion	Marked and sustained improvement two years after autologous stem cell transplantation in a girl with systemic sclerosis.	10211898
Peripheral Stem Cell Transplantation, Systemic Scleroderma	Stem Cell Exhaustion	A 12-year-old girl who, since 4 years of age, had systemic sclerosis with progressive pulmonary involvement underwent autologous peripheral blood-derived stem cell transplantation (aPBSCT) using CD34+ selection, cyclophosphamide, and the infusion of the monoclonal antibody CAMPATH-1G.	10211898
Autoimmune Diseases	Stem Cell Exhaustion	Autologous transplantation of hematopoietic stem cells has recently been proposed as a possible treatment for autoimmune diseases that are associated with a very severe prognosis.	10211898
Small cell carcinoma of lung, Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	He had earlier been given a diagnosis of SCLC, oat cell carcinoma, and had undergone high-dose chemotherapy with peripheral blood stem cell transplantation during his first admission.	10214046
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	A prospective study of autologous bone marrow or peripheral blood stem cell transplantation after intensive chemotherapy in myelodysplastic syndromes.	10214857
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	We prospectively assessed autologous stem cell transplantation for consolidation treatment in a trial of intensive chemotherapy in high risk myelodysplastic syndromes (MDS).	10214857
PAFAH1B1 wt Allele	Stem Cell Exhaustion	PBSC collection may yield higher numbers of stem cells than marrow collection in some cases, and could improve the percentage of MDS patients autografted in CR.	10214857
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Cytopenia, leukemia, Hemorrhage, Communicable Diseases	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) caused by a clonal hematopoietic stem cell disorder progress to either overt leukemia or cytopenia, which leads to lethal infection or bleeding.	10214861
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Quantitation of minimal residual disease in acute myelogenous leukemia and myelodysplastic syndromes in complete remission by molecular cytogenetics of progenitor cells.	10214863
Trauma	Stem Cell Exhaustion	Establishment of long-term multilineage chimerism in trauma recipients is probably caused by engraftment of donor stem cells and mutual tolerance between recipient and donor leukocytes.	10216112
Small cell carcinoma of lung	Stem Cell Exhaustion	High-dose ifosfamide, carboplatin and etoposide with autologous peripheral blood progenitor cell transplantation for small-cell lung cancer.	10216478
Small cell carcinoma of lung	Stem Cell Exhaustion	We investigated the feasibility and efficacy of high-dose chemotherapy consisting of ifosfamide, carboplatin and etoposide (HD-ICE) facilitated by autologous peripheral blood progenitor cell transplantation (ABPCT) for the treatment of small-cell lung cancer (SCLC).	10216478
Childhood Breast Carcinoma	Stem Cell Exhaustion	Mitoxantrone in elderly patients with advanced breast cancer: pharmacokinetics, marrow and peripheral hematopoietic progenitor cells.	10216510
Infection	Stem Cell Exhaustion	Early infections in patients undergoing bone marrow or blood stem cell transplantation--a 7 year single centre investigation of 409 cases.	10217190
Infection	Stem Cell Exhaustion	Infections are a major cause of morbidity and mortality in patients undergoing high-dose therapy and subsequent autologous or allogeneic haemopoietic stem cell transplantation, despite the change from topical to systemic anti-infection prophylaxis and the introduction of growth factors and new antimicrobial drugs.	10217190
Cessation of life, Infection	Stem Cell Exhaustion	Infections remain a major risk for early death after allogeneic transplantation of haemopoietic stem cells.	10217190
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Peripheral blood stem cell contamination in mantle cell non-Hodgkin lymphoma: the case for purging?	10218844
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Intensification using peripheral blood stem cells collected after chemotherapy followed by growth factors is being increasingly investigated as an alternative to conventional chemotherapy for mantle cell non-Hodgkin lymphoma.	10218844
Rheumatoid Arthritis	Stem Cell Exhaustion	The current studies examined the influences of methotrexate (MTX), a potent disease modifying antirheumatic drug (DMARD), on the capacity of bone marrow progenitor cells to generate CD14(+) cells in patients with RA, in order to delineate its mechanism of action.	10219258
leukemia	Stem Cell Exhaustion	We reasoned that a leukemia had occurred in this patient at a progenitor cell level common to both erythroid and megakaryocytic lineages.	10222631
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Since MDS is regarded as a stem cell disorder, the present studies were undertaken to examine the relative susceptibility and propensity of early progenitor CD34+ cells to undergo apoptosis as compared to more maturing/matured CD34- cells.	10222652
Hematologic Neoplasms, Pluripotent Stem Cells, Malignant Neoplasms, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The occurrence of 2 distinct hematologic malignancies in the same patient suggests either a different clonal evolution from a common pluripotent malignant stem cell since the CML stem cell also involves the B-lymphoid lineage, a coincident complication of the 2 hematological malignancies, or the coexistence of 2 distinct malignancies due to the same genetic background and/or exposure to similar carcinogenic agents.	10222655
Acute leukemia	Stem Cell Exhaustion	Unrelated umbilical cord blood (UCB) as a source of haematopoietic stem/progenitor cells has been used for the first time in Sweden for allografting two boys (6 and 11 1/2 years old) with acute leukaemia in complete remission.	10222704
PAFAH1B1 wt Allele	Stem Cell Exhaustion	We conclude that within the hypocellular variant of MDS, there may be two distinct sub-groups of patients, one who present with high cytokine-mediated intramedullary apoptosis and the other who may be better characterized as having a stem-cell failure defect since they showed no evidence of apoptosis.	10229321
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Hematopoietic progenitor cells from patients with myelodysplastic syndromes: in vitro colony growth and long-term proliferation.	10229325
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	It is known that the levels of hematopoietic progenitor cells (HPC) are greatly reduced in the majority of patients with myelodysplastic syndromes (MDS).	10229325
PAFAH1B1 wt Allele	Stem Cell Exhaustion	In the present study, we have determined the HPC content in the bone marrow of 12 MDS patients and followed the proliferation kinetics of myeloid (including granulocyte, macrophage and granulocyte macrophage), erythroid (including early and late) and multipotent progenitor cells in LTMC throughout a 7-week culture period.	10229325
Infection	Stem Cell Exhaustion	Infections following peripheral blood progenitor cell transplantation for lymphoproliferative malignancies: etiology and potential risk factors.	10230749
Infection	Stem Cell Exhaustion	We sought to describe the infections that occur after large-dose chemotherapy, which was followed by autologous peripheral blood progenitor cell transplantation, and to determine their risk factors.	10230749
Bacteremia, Toxic effect	Stem Cell Exhaustion	This study confirms that infectious toxicity after peripheral blood progenitor cell transplantation is usually moderate, although bacteremia remains a serious problem.	10230749
Multiple Myeloma	Stem Cell Exhaustion	Low incidence of human herpesvirus 8 in stem cell collections from myeloma patients.	10231136
Neoplasms	Stem Cell Exhaustion	Almost half the tumours were stained positively for CD34 and 48 of 61 tumours were positive for c-kit (CD117), a marker of haematopoietic progenitor cells, mast cells and the so-called interstitial cell of Cajal (ICC).	10231416
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Haemopoietic reconstitution by donor-derived myelodysplastic progenitor cells after haemopoietic stem cell transplantation.	10233404
Refractory Non-Hodgkin Lymphoma, PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	A 50-year-old woman who was retrospectively diagnosed with an early asymptomatic myelodysplastic syndrome (MDS) served as a haemopoietic stem cell donor for her HLA-identical sister who had chemotherapy-refractory non-Hodgkin's lymphoma.	10233404
PAFAH1B1 wt Allele, Neoplasms	Stem Cell Exhaustion	This implies that MDS progenitor cells may not have homing and growth deficiencies, a finding that has particular relevance for autologous transplantation in MDS patients where tumour cells potentially contaminate the graft.	10233404
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In the present study, we have explored the possible value of the analysis of the distribution of CD34+ myeloid and CD34+ lymphoid progenitor cells in follow-up complete remission bone marrow samples from de novo AML patients as a prognostic parameter for predicting relapse.	10323219
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Double haploidentical transplantation of hematopoietic progenitor cells in a boy with myelodysplastic syndrome.	10326225
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	A 12-year-old boy with myelodysplastic syndrome underwent a double transplantation of hematopoietic progenitor cells from his haploidentical brother.	10326225
Multiple Myeloma	Stem Cell Exhaustion	Plasmablastic morphology is an independent predictor of poor survival after autologous stem-cell transplantation for multiple myeloma.	10334543
Plasmablast (cell), Multiple Myeloma	Stem Cell Exhaustion	To study the prognostic value of plasmablastic morphology after autologous stem-cell transplantation for relapsed or primary refractory myeloma.	10334543
Multiple Myeloma	Stem Cell Exhaustion	Plasmablastic morphology is a powerful independent predictor of poor survival rate after autologous stem-cell transplantation for relapsed or primary refractory myeloma.	10334543
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Leukemic blast cells express the CD33 antigen in most patients with acute myeloid leukemia (AML), but this antigen is not expressed by hematopoietic stem cells.	10339474
Multiple Myeloma	Stem Cell Exhaustion	Moreover, peripheral blood stem cell collections from myeloma patients contained higher numbers of CD16(+) cells than PBMCs and exhibited ADCC activity that was enhanced by IL-2.	10339501
Icterus	Stem Cell Exhaustion	The results indicate donor stem cells (a) prolong life in the jaundiced mice, but (b) do not survive long-term when injected into newborn mice.	10340413
Aplastic Anemia	Stem Cell Exhaustion	Effect of interleukin 10 on the hematopoietic progenitor cells from patients with aplastic anemia.	10342557
Aplastic Anemia	Stem Cell Exhaustion	In this study, therefore, we examined the effect of IL-10 on progenitor cells obtained from seven patients with severe aplastic anemia.	10342557
Toxic effect	Stem Cell Exhaustion	Toxicity of autologous peripheral blood progenitor cell transplant included serious liver and pulmonary toxicity in 2 and 1 patient, respectively.	10342575
Secondary Acute Myeloid Leukemia	Stem Cell Exhaustion	Transplantation of autologous peripheral blood progenitor cells procured after high-dose cytarabine-based consolidation chemotherapy for adults with secondary acute myelogenous leukemia in first remission.	10342575
Secondary Acute Myeloid Leukemia	Stem Cell Exhaustion	The purpose of this study is to evaluate, on the basis of intention to treat, the feasibility and efficacy of high-dose cytarabine/anthracycline consolidation chemotherapy followed by autologous transplantation of chemotherapy/rHuG-CSF-mobilized peripheral blood progenitor cells for seventeen adult patients (median age 63, range 27 to 68) with secondary acute myelogenous leukemia in first remission.	10342575
Toxic effect, Secondary Acute Myeloid Leukemia	Stem Cell Exhaustion	Our results demonstrate that a postremission program of high-dose cytarabine-based consolidation chemotherapy followed by autologous transplantation of chemotherapy-mobilized peripheral blood progenitor cells is feasible for patients with secondary acute myelogenous leukemia producing prolonged leukemia-free survival with minimal toxicity.	10342575
Scleroderma	Stem Cell Exhaustion	Increased cutaneous immunoreactive stem cell factor expression and serum stem cell factor level in systemic scleroderma.	10342750
Stem Cell Factor	Stem Cell Exhaustion	Stem cell factor (SCF, c-kit ligand) is a multifunctional cytokine which can promote melanocyte and mast cell development.	10342750
White blood cell count decreased	Stem Cell Exhaustion	We postulate that the worsened leukopenia results from the effects of concurrent radiotherapy on circulating stem cells.	10348282
Toxic effect	Stem Cell Exhaustion	In addition, these studies demonstrate that relatively small radiotherapy fields can deliver a dose to circulating stem cells sufficient to worsen the hematologic toxicity of concurrent myelosuppressive chemotherapy, a phenomena which should be considered in the design of combined modality protocols for other body sites.	10348282
Acute leukemia	Stem Cell Exhaustion	Immunophenotypes of 33 samples from patients with acute leukemia were analyzed using a panel of these monoclonal antibodies: anti-immature/stem cell (HLA-DR, CD34); anti-mature myeloid (CD33, CD15); anti-T lymphoid (CD2, CD3, CD5, CD7, CD8), and anti-B lymphoid (CD10, CD19, CD20).	10352329
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Our findings indicate that AML cells with t(16;21) preserve stem cell properties such as CD34 and c-kit expression, and suggest that they have the potential to differentiate into a monocytic lineage.	10354136
Fatigue, Childhood Breast Carcinoma	Stem Cell Exhaustion	Fatigue and quality of life in breast cancer patients undergoing autologous stem cell transplantation: a longitudinal comparative study.	10355210
Specialty Type - cancer	Stem Cell Exhaustion	As more individuals are being treated for cancer with high-dose therapy and autologous stem cell rescue (ASCR), there is growing interest in treatment side effects and their impact on quality of life.	10355210
Extragonadal Germ Cell Tumor	Stem Cell Exhaustion	[High-dose chemotherapy followed by peripheral blood stem cell transplantation in advanced extragonadal germ cell tumor--a case report].	10355255
Neoplasms	Stem Cell Exhaustion	We reported the experience of high-dose chemotherapy (HDC) combined with peripheral stem cell transplantation (PBSCT) in 29 years-old man with advanced retroperitoneal germ cell tumor accompanied with left supraclavicular lymph node metastases, who obtained complete remission after comprehensive treatment.	10355255
Harvesting of peripheral blood stem cells	Stem Cell Exhaustion	Electrolyte monitoring in patients undergoing peripheral blood stem cell collection.	10355658
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Multicenter randomized phase II trial of idarubicin vs mitoxantrone, combined with VP-16 and cytarabine for induction/consolidation therapy, followed by a feasibility study of autologous peripheral blood stem cell transplantation in elderly patients with acute myeloid leukemia.	10360370
melanoma, Neoplasms	Stem Cell Exhaustion	This agent demonstrates promising preclinical antitumor activity, including activity against B16 melanoma and against melanoma isolates in the human tumor stem cell assay.	10360606
Histiocytosis, Histiocytosis, Langerhans-Cell	Stem Cell Exhaustion	Langerhans-cell histiocytosis (LCH) results from the accumulation of tissue histiocytes derived from the same progenitor cells as monocytes.	10361109
Juvenile Myelomonocytic Leukemia, Autoimmune Diseases, Abnormality of red blood cells	Stem Cell Exhaustion	The patient is the first example to show close relationship between stem cell abnormalities in JMML and development of overt autoimmune disorders.	10363633
Adenoma, Mitochondrial Inheritance	Stem Cell Exhaustion	Electron microscopy revealed an undifferentiated, monomorphous adenoma with morphological features of an acidophil stem cell adenoma such as the presence of misplaced exocytoses, fibrous bodies and mitochondrial gigantism.	10366409
Pituitary Adenoma, Spermatocytogenesis	Stem Cell Exhaustion	This undifferentiated, monomorphous GH/TSH-secreting pituitary adenoma represents an entity that is unusual both in its ultrastructural features and clinical manifestations suggesting a cytogenesis from an early, undifferentiated stem cell.	10366409
Multiple Myeloma	Stem Cell Exhaustion	Melphalan 220 mg/m2 followed by peripheral blood stem cell transplantation in 27 patients with advanced multiple myeloma.	10373065
Peripheral Stem Cell Transplantation, Neoplasms, Multiple Myeloma	Stem Cell Exhaustion	Analysis of circulating tumor cells in patients with multiple myeloma during the course of high-dose therapy with peripheral blood stem cell transplantation.	10373068
Neoplasms	Stem Cell Exhaustion	We determined the number of tumor cells in the CD19+ as well as CD19- fractions of PB of eight patients with disease sensitive to VA[I]D chemotherapy, of 10 patients who achieved partial or complete remission post-high-dose therapy (HDT) with peripheral blood stem cell transplantation (PBSCT) and of a further seven patients with disease progression post-transplantation.	10373068
Clostridium difficile colitis	Stem Cell Exhaustion	Incidence and outcome of Clostridium difficile infection following autologous peripheral blood stem cell transplantation.	10373070
Clostridium difficile, Communicable Diseases	Stem Cell Exhaustion	A retrospective evaluation of 200 consecutive recipients of autologous peripheral blood stem cell transplantation (PBSCT) was conducted to ascertain the incidence and outcome of infection with Clostridium difficile.	10373070
Diarrhea	Stem Cell Exhaustion	The diagnosis was confirmed in 14 patients with diarrhea (15 episodes) at a median of 33 days after stem cell infusion.	10373070
Pneumocystis carinii, Cytomegaloviral pneumonia	Stem Cell Exhaustion	Concurrent Pneumocystis carinii and cytomegalovirus pneumonia after autologous peripheral blood stem cell transplantation.	10373078
Cytomegalovirus Infections, Phencyclidine, Pneumocystis jiroveci pneumonia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 46-year-old woman developed concurrent CMV and Pneumocystis carinii pneumonia (PCP) 140 days after autologous peripheral blood stem cell transplantation (APBSCT) for AML.	10373078
Graves Disease	Stem Cell Exhaustion	Adoptive autoimmune hyperthyroidism following allogeneic stem cell transplantation from an HLA-identical sibling with Graves' disease.	10373079
Disseminated eosinophilic collagen disease, Cardiac dysfunction	Stem Cell Exhaustion	Allogeneic peripheral blood stem cell transplantation for hypereosinophilic syndrome with severe cardiac dysfunction.	10373080
Ewings sarcoma, BCR gene	Stem Cell Exhaustion	Peripheral blood stem cell transplantation from a matched sibling was performed successfully and he is in complete remission of both ALL and Ewing's sarcoma.	10374854
Cessation of life, Disability	Stem Cell Exhaustion	In utero stem cell transplantation promises a novel therapeutic approach to those genetic disorders that can be diagnosed in early pregnancy and that could lead to either severe disability or death.	10377519
Rheumatoid Arthritis	Stem Cell Exhaustion	Risk taking in patients with rheumatoid arthritis: are the risks of haemopoietic stem cell transplantation acceptable?	10378708
Rheumatoid Arthritis	Stem Cell Exhaustion	Autologous haemopoietic stem cell transplantation (HSCT), which carries defined risks of early treatment-related mortality (TRM), has recently been proposed as an experimental therapy for severe rheumatoid arthritis (RA).	10378708
Childhood Breast Carcinoma	Stem Cell Exhaustion	To determine whether the multidrug resistance gene MDR1 could act as a selectable marker in human subjects, we studied engraftment of peripheral blood progenitor cells (PBPCs) transduced with either MDR1 or the bacterial NeoR gene in six breast cancer patients.	10381498
Pregnancy Complications, Infectious	Stem Cell Exhaustion	We conclude that transplantation with a stem cell dose of at least 5 x 10(6)/kg CD34+ cells reduces infectious complications and should thereby increase the safety of this type of therapy while reducing duration (and cost) of antibiotic therapy.	10382958
Autoimmune Diseases	Stem Cell Exhaustion	The potential implications on pathogenesis of the disease as well as on treatment of autoimmune disorders by stem cell transplantation are discussed.	10382963
Injury of liver	Stem Cell Exhaustion	The stem cell factor (SCF)/c-kit ligand/receptor system has been implicated in stem (oval) cell activation following liver injury in the rat.	10385646
Adenocarcinoma, Neoplasms	Stem Cell Exhaustion	We suggest that this tumour has a stem cell origin and does not derive from a dedifferentiated adenocarcinoma or from benign NE cells of the prostatic epithelium.	10389621
Childhood Breast Carcinoma	Stem Cell Exhaustion	Ten patients with breast cancer were included in a clinical trial in which r-metHuG-CSF was administered daily for 5 days to mobilize peripheral blood stem cells.	10390001
Hematologic Neoplasms	Stem Cell Exhaustion	A significant proportion of patients with hematologic malignancies fail to mobilize sufficient hemopoietic progenitor cells (HPC), thereby restricting wider application of autologous transplantation.	10390196
SERPINB3 wt Allele	Stem Cell Exhaustion	Thus, TC-YIK cells have been shown to differentiate both into macrophage lineage cells and neuronal cells, suggesting that ASCC originates from undifferentiated stem cells.	10391092
Sebaceous Gland Neoplasms	Stem Cell Exhaustion	The results also support the suggestion that ocular sebaceous neoplasms arise from a common stem cell, rather than from either sebaceous or basal/ductal cells.	10396393
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	In conclusion, this prospective comparison of molecular and cytogenetic residual disease demonstrates that peripheral blood stem cell transplants have a more pronounced activity against residual CML cells than bone marrow transplants.	10397704
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Prospective randomized trials comparing PBSCT and BMT in patients with first chronic phase Ph1-positive CML are strictly required to further substantiate differences in the antileukemic activity of the two stem cell sources.	10397704
Cytogenetics, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The risk of residual molecular and cytogenetic disease in patients with Philadelphia-chromosome positive first chronic phase chronic myelogenous leukemia is reduced after transplantation of allogeneic peripheral blood stem cells compared with bone marrow.	10397704
Cytogenetics, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The detection of residual molecular and cytogenetic disease was prospectively compared in patients with Philadelphia-chromosome (Ph1) positive first chronic phase chronic myelogenous leukemia (CML) who underwent allogeneic transplantation of unmanipulated peripheral blood stem cells (PBSCT) (n = 29) or bone marrow (BM) (n = 62) using genotypically HLA-identical sibling donors or partially HLA-matched extended family donors.	10397704
Stem Cell Factor, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We examined the effect of recombinant human interleukin (IL)-11 alone or in combination with various colony-stimulating factors (CSFs), including IL-3, granulocyte/macrophage (GM)-CSF, granulocyte (G)-CSF, stem cell factor (SCF), flt3 ligand (FL), and thrombopoietin (TPO), on colony formation by leukemic progenitor cells (L-CFU) obtained from 33 patients with acute myelogenous leukemia (AML).	10400417
Anemia, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Chromosome Aberrations	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are a group of refractory anemias resulting from a clonal stem cell disorder often associated with cytogenetic abnormalities.	10402176
Omenn Syndrome	Stem Cell Exhaustion	This study discusses the case of a 19-month-old child with Omenn's syndrome, who received an unrelated cord blood stem cell transplant (CBT).	10407874
Lupus Erythematosus, Encephalitis, St. Louis	Stem Cell Exhaustion	A 35 y old woman with severe and progressive systemic lupus erythematosus (SLE) received high-dose chemotherapy followed by a T cell depleted autologous stem cell transplantation.	10413212
Encephalitis, St. Louis	Stem Cell Exhaustion	In conclusion, we report here the favourable evolution of a patient with a severe SLE, who clinically improved with high-dose immunosuppressive therapy and autologous stem cell transplantation, and showed a 9 month serological remission.	10413212
Lupus Erythematosus	Stem Cell Exhaustion	Control of severe systemic lupus erythematosus after high-dose immunusuppressive therapy and transplantation of CD34+ purified autologous stem cells from peripheral blood.	10413212
Aggressive Non-Hodgkin Lymphoma, Lymphoma, Non-Hodgkin, Familial, HD Term Type, Hodgkin Disease	Stem Cell Exhaustion	High-dose chemotherapy (HDCT) followed by autologous blood stem cell transplantation is considered the treatment of choice for patients with relapsed or resistant aggressive non-Hodgkin's lymphoma (NHL) or Hodgkin's disease (HD).	10414907
Lymphoma	Stem Cell Exhaustion	Here we report the results of using etoposide as a mobilizing agent in 16 patients with primary resistant or relapsed malignant lymphoma who had failed prior mobilization of peripheral blood stem cells (PBSC) with cyclophosphamide (4 g/m2) followed by G-CSF.	10414907
Hematologic Neoplasms	Stem Cell Exhaustion	We have studied a total of 188 patients with hematological malignancies, submitted to mobilization therapy with G-CSF associated or not with chemotherapy in order to: (1) establish the lower limit of circulating progenitor cells that allows the collection of 2 x 10(6) CD34+ cells/kg by a single leukapheresis, utilizing the instrument set on standard parameters; (2) evaluate whether the number and quality of CD34+ cells collected remain stable during leukapheresis; and (3) collect a sufficient number of circulating CD34+ cells by a single procedure in patients in whom such an approach would have been insufficient to reach the target with the instrument set on standard parameters.	10414908
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation for relapsed and primary refractory myeloma.	10414914
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Peripheral blood stem cell transplantation as an alternative to autologous marrow transplantation in the treatment of acute myeloid leukemia?	10414916
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Here we present a study in which the feasibility of mobilizing stem cells was investigated in newly diagnosed AML.	10414916
Childhood Breast Carcinoma	Stem Cell Exhaustion	Immunohistochemical detection of breast cancer cells in paired peripheral blood progenitor cell specimens collected after cytokine or cytokine and myelosuppressive chemotherapy.	10414919
Childhood Breast Carcinoma, Neoplasms	Stem Cell Exhaustion	Mobilized peripheral blood progenitor cells (PBPC) from 30 patients with advanced breast cancer were studied for the presence of tumor cell contamination using a highly sensitive immunohistochemical technique with the capacity to detect one tumor cell in one million mononuclear cells.	10414919
Toxic effect, Malignant Neoplasms	Stem Cell Exhaustion	Toxicities after peripheral blood progenitor cell transplantation for lymphoid malignancies: analysis of 300 cases in a single institution.	10414921
Killer Cells	Stem Cell Exhaustion	Successful treatment of advanced natural killer cell lymphoma with high-dose chemotherapy and syngeneic peripheral blood stem cell transplantation.	10414923
Malignant histiocytosis	Stem Cell Exhaustion	A 16-year-old Japanese girl with advanced CD56+ angiocentric lymphoma received high-dose chemotherapy supported with syngeneic peripheral blood stem cell transplantation (PBSCT).	10414923
Adenocarcinoma, Carcinoma	Stem Cell Exhaustion	In patients younger than 61 years with an ECOG performance status of 0 or 1, poorly differentiated adenocarcinoma or poorly differentiated carcinoma, and no evidence of brain or bone marrow involvement (group A), the treatment plan included four sequential high-dose courses with hematopoietic progenitor cell and growth factor support.	10416007
Hematopoietic stem cells	Stem Cell Exhaustion	The absolute number of circulating CD34+ cells as the best predictor of peripheral hematopoietic stem cell yield.	10417048
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	[Myelodysplastic syndrome after autologous peripheral blood stem cell transplantation for adult acute myelogenous leukemia].	10423926
Hematologic Neoplasms, Leukemia, Myelocytic, Acute, Multiple Myeloma, Acute lymphocytic leukemia	Stem Cell Exhaustion	The subjects of the study were patients with hematological malignancies (acute myeloid leukemia, acute lymphoblastic leukemia, and multiple myeloma), and stem cell transplant donors.	10425303
Anemia	Stem Cell Exhaustion	Treatment of aregeneratoric anemia following an ABO-incompatible allogeneic peripheral blood stem cell transplantation: a case report.	10427629
Anemia	Stem Cell Exhaustion	Aregeneratoric anemia (AA) occurs rarely after ABO-incompatible allogeneic peripheral blood stem cell transplantation (alloPBSCT), and its management is generally difficult.	10427629
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Here, we present a 31-year-old white man with myelodysplastic syndrome who developed AA after receiving stem cells from his human leukocyte antigen (HLA) identical, but ABO-incompatible sibling.	10427629
Malignant neoplasm of lung	Stem Cell Exhaustion	However, it is not clear whether ATase activity in these samples correlates well with the activity found in bronchial epithelial cells, the progenitor cells for the main types of lung cancer.	10428203
Aplastic Anemia	Stem Cell Exhaustion	This may contribute to understanding the decreased number of stem cells characteristic of aplastic anemia.	10434475
Multiple Myeloma	Stem Cell Exhaustion	Eighty-eight previously autografted (78 transplanted twice and 10 once) myeloma patients who had no cryopreserved stem cells available for possible future use received G-CSF for mobilization of stem cells.	10435728
malignant disease, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	These findings have practical implications for patients with malignant diseases in remission after autografting who may be candidates for future salvage therapy but have no stem cells stored, and for patients with chronic myeloid leukemia who are on long-term interferon-alpha therapy to attain cytogenetic remission for eventual collection of normal stem cells.	10435728
Multiple Myeloma	Stem Cell Exhaustion	The kinetics of mobilization and optimal timing of peripheral blood progenitor cell (PBPC) collection were evaluated in 190 patients with multiple myeloma undergoing stem cell harvest after mobilization with cyclophosphamide, prednisone and G-CSF.	10435730
Cytomegalovirus viremia, Viruria	Stem Cell Exhaustion	Cytomegalovirus viremia, viruria and disease after autologous peripheral blood stem cell transplantation: no need for surveillance.	10435738
Communicable Diseases	Stem Cell Exhaustion	A retrospective evaluation of 200 consecutive recipients of autologous peripheral blood stem cell transplantation (PBSCT) was conducted to ascertain the incidence, risk factors, clinical features, complications, and outcome of cytomegalovirus (CMV) infection.	10435738
Persistent CMV viremia	Stem Cell Exhaustion	A total of 26 patients (13%) developed CMV viremia (n = 5), DNAemia (n = 3), viruria (n = 18) and/or disease (n = 3) at a median of 45 days following stem cell infusion.	10435738
Viruria, Persistent CMV viremia	Stem Cell Exhaustion	All instances of CMV viremia, DNAemia, viruria and disease occurred within 3 months of stem cell infusion.	10435738
Multiple Myeloma	Stem Cell Exhaustion	Stem cell factor in combination with filgrastim after chemotherapy improves peripheral blood progenitor cell yield and reduces apheresis requirements in multiple myeloma patients: a randomized, controlled trial.	10438709
Multiple Myeloma	Stem Cell Exhaustion	Dose-intensive melphalan with stem cell support (MEL100) is superior to standard treatment in elderly myeloma patients.	10438712
Acute GVH disease	Stem Cell Exhaustion	Risk factors for acute graft-versus-host disease after allogeneic blood stem cell transplantation.	10438735
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	We evaluated demographic characteristics and graft composition as risk factors for acute graft-versus-host disease (GVHD) in 160 adult recipients of HLA-identical allogeneic blood stem cell transplants.	10438735
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	A pilot study of a response oriented chemotherapeutic regimen combined with autologous peripheral blood progenitor cell transplantation in aggressive non-Hodgkin's lymphoma.	10439373
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	A 55-year-old man experienced persistent oral graft versus host disease after receiving an HLA-matched allogeneic stem cell peripheral blood transplant for chronic myeloid leukaemia.	10439530
Peripheral Blood Stem Cells, Malignant neoplasm of testis	Stem Cell Exhaustion	[Two-step ultra high-dose chemotherapy with peripheral blood stem cell autotransplantation for refractory testicular cancer: a case report].	10442292
Secondary Neoplasm	Stem Cell Exhaustion	Because he developed lung metastasis, escalated doses of carboplatin (2.0 g/m2), and etoposide (1.8 g/m2) combined with cyclophosphamide (7.0 g/m2) were given with peripheral blood stem cell transplant of 3.2 x 10(5)/kg CFU-GM.	10442292
Waldenstrom Macroglobulinemia	Stem Cell Exhaustion	Myeloablative radiochemotherapy followed by reinfusion of purged autologous stem cells for Waldenstrom's macroglobulinaemia.	10444173
Tumor necrosis	Stem Cell Exhaustion	When fresh or thawed cells are cultured with granulocyte-macrophage colony-stimulating factor and stem cell factor with or without tumour necrosis factor-alpha (TNF-alpha), they generate numerous cells with the characteristic ultrastructural, phenotypic and functional properties of dendritic cells.	10447749
Anemia	Stem Cell Exhaustion	In male subjects chronically exposed to lead with and without anaemia, pluripotent (CFU-GEMM), BFU-E and granulocyte/macrophage (CFU-GM) progenitor cell counts in peripheral blood were measured with a modified clonal assay.	10448314
Anemia, Erythroid Progenitor Cells	Stem Cell Exhaustion	Dose dependent reduction of erythroid progenitor cells and inappropriate erythropoietin response in exposure to lead: new aspects of anaemia induced by lead.	10448314
Stromal Neoplasm	Stem Cell Exhaustion	CD34 is a marker of haematopoietic progenitor cells, stromal precursors, vascular endothelial cells, and a variety of stromal tumour cells.	10451496
Autoimmune Diseases	Stem Cell Exhaustion	Immunoablation followed by stem cell transplantation has been shown to be capable of inducing remissions in a large spectrum of experimental autoimmune disorders.	10455352
Acute GVH disease	Stem Cell Exhaustion	Comparison of the classic Glucksberg criteria and the IBMTR Severity Index for grading acute graft-versus-host disease following HLA-identical sibling stem cell transplantation.	10455367
HLA Mismatch, GDC Disease Response Terminology, X-Linked Lymphoproliferative Disorder	Stem Cell Exhaustion	An 8-month-old male with X-linked lymphoproliferative disease underwent an unrelated, partially matched (with major mismatch at DR locus), cord blood stem cell transplant.	10455373
Decreased platelet count	Stem Cell Exhaustion	Vincristine should be considered as a treatment for refractory immune thrombocytopenia after hematopoietic stem cell transplantation.	10455373
Decreased platelet count	Stem Cell Exhaustion	Immune thrombocytopenia after umbilical cord progenitor cell transplant: response to vincristine.	10455373
Autoimmune thrombocytopenia, Small cell carcinoma of lung	Stem Cell Exhaustion	Autoimmune thrombocytopenia in a patient with small cell lung cancer developing after chemotherapy and resolving following autologous peripheral blood stem cell transplantation.	10455376
Immune thrombocytopenic purpura, Small cell carcinoma of lung, Peripheral Blood Stem Cells	Stem Cell Exhaustion	A 46-year-old white male with small cell lung cancer (SCLC) limited to the thorax developed autoimmune thrombocytopenic purpura (AITP), following a cyclophosphamide, paclitaxel and G-CSF-containing regimen for peripheral blood stem cell (PBSC) mobilization.	10455376
Chronic granulomatous disease	Stem Cell Exhaustion	Donor lymphocyte infusion post-non-myeloablative allogeneic peripheral blood stem cell transplantation for chronic granulomatous disease.	10455377
BCR gene	Stem Cell Exhaustion	Our results suggest that patients with this genetic abnormality who have T-cell ALL or are 1 to 9 years of age should not be considered candidates for hematopoietic stem-cell transplantation during their first remission.	10458233
Peripheral Blood Stem Cells, Impaired	Stem Cell Exhaustion	Impaired T and NK cell response of bone marrow and peripheral blood stem cell products to interleukin (IL)-2.	10458540
Multiple Myeloma, Chromosome Aberrations	Stem Cell Exhaustion	We report the relationship between chromosomal abnormalities and known prognostic factors such as plasma cell labeling index (PCLI) and bone marrow plasma cell involvement in 75 consecutive patients undergoing autologous stem cell transplantation for relapsed or refractory myeloma.	10459351
Peripheral Stem Cell Transplantation, Multiple Myeloma	Stem Cell Exhaustion	Clonotypic CD20+ and CD19+ B cells in peripheral blood of patients with multiple myeloma post high-dose therapy and peripheral blood stem cell transplantation.	10460621
Peripheral Stem Cell Transplantation, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The number of circulating clonotypic B cells in patients with multiple myeloma (MM) after high-dose therapy (HDT) with peripheral blood stem cell transplantation (PBSCT) was investigated.	10460621
Shwachman syndrome	Stem Cell Exhaustion	Neuromuscular choristomas arising in connection with congenital lipomas may derive from a dysembryogenic process of stem cells of the caudal neural tube.	10463034
Hematologic Neoplasms	Stem Cell Exhaustion	Relapse remains the major cause of mortality in haematological malignancies treated with autologous stem cell transplantation (ASCT).	10464707
Aplastic Anemia	Stem Cell Exhaustion	Granulocyte colony-stimulating factor-supported combined immunosuppressive therapy (antilymphocyte globulin, cyclosporine, and methylprednisolone) in patients with aplastic anemia: tolerability, efficacy, and changes in the progenitor cell compartment.	10466441
Neurologic Deficits	Stem Cell Exhaustion	Although the haploidentical brother of the patient may serve as an allogeneic stem cell donor, transplantation has been postponed because of further deterioration of her already existing CHS-specific neurological impairment.	10466444
Bone Marrow, Leukocytosis	Stem Cell Exhaustion	This initial coagulation response was followed by a second phase of hematological response (starting on days 15-20) characterized by leukocytosis, occurrence of myeloid progenitor cells in the peripheral blood, and a decrease in bone marrow blasts (<1% on days 28 and 36).	10466445
Hepatomegaly, Congenital macroglossia, Purpura	Stem Cell Exhaustion	Improvement of amyloid-related symptoms after autologous stem cell transplantation in a patient with hepatomegaly, macroglossia and purpura.	10467336
Deficiency	Stem Cell Exhaustion	Major histocompatibility complex (MHC) class II deficiency is a rare form of primary combined immunodeficiency that can only be corrected by stem cell transplantation.	10467337
Graft failure, Immunologic Deficiency Syndromes	Stem Cell Exhaustion	We conclude that cord blood may be an effective source of hematopoietic stem cells for patients with immuno- deficiency disorders including diseases with a high rate of graft failure.	10467337
Amyloidosis	Stem Cell Exhaustion	Clonal immunoglobulin light chain variable region germline gene use in AL amyloidosis: association with dominant amyloid-related organ involvement and survival after stem cell transplantation.	10468868
Communicable Diseases, Pseudomonas aeruginosa, Infection, leukemia	Stem Cell Exhaustion	Patients with EB and P. aeruginosa bacteremia usually developed the infection after intensive chemotherapy for leukemia or during a hematopoietic stem cell transplantation, while most infections in outpatients off therapy were due to NGFGNB.	10473881
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The further use of this assay should facilitate studies of AML stem cell biology and the evolution of novel therapeutic strategies.	10477702
Multiple Myeloma	Stem Cell Exhaustion	Blood stem cell collection using chemotherapy with or without systematic G-CSF: experience in 52 patients with multiple myeloma.	10482928
Hodgkin Disease, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Randomized trial of peripheral blood progenitor cell vs bone marrow as hematopoietic support for high-dose chemotherapy in patients with non-Hodgkin's lymphoma and Hodgkin's disease: a clinical and molecular analysis.	10482930
Lymphoma, Non-Hodgkin, Familial, Hodgkin Disease, HD Term Type, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Filgrastim (r-metHuG-CSF)-mobilized peripheral blood progenitor cells (PBPC) and unstimulated bone marrow (BM) were evaluated and compared for reconstitution after high-dose chemotherapy in patients with relapsed Hodgkin's disease (HD) or non-Hodgkin's lymphoma (NHL) with respect to engraftment, overall and relapse-free survival, and contamination by lymphoma cells using molecular analysis of immunoglobulin gene rearrangements.	10482930
Childhood Breast Carcinoma	Stem Cell Exhaustion	We measured the concentration of CD34+ cells in peripheral blood (PB) (1/2) h prior to and (1/2), 1, 3, 6, and 12 h following hematopoietic stem cell (HSC) infusion in 34 breast cancer patients treated with high-dose chemotherapy (HDC).	10482931
Secondary malignant neoplasm of female breast	Stem Cell Exhaustion	[High-dose chemotherapy with autologous peripheral blood stem cell transplantation support in a patient with breast cancer metastasis to bone marrow: immunocytochemical monitoring of cancer-cell contamination].	10483138
Infant T Acute Lymphoblastic Leukemia, Thrombotic Microangiopathies	Stem Cell Exhaustion	[Infantile T cell acute lymphoblastic leukemia complicated by thrombotic microangiopathy and human herpes virus 6 infection after allogeneic peripheral blood stem cell transplantation using CD34-positive cells].	10483141
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Stem Cell Exhaustion	We report on a 19-month-old boy with refractory T-cell acute lymphoblastic leukemia who underwent allogeneic peripheral blood stem cell transplantation using positively selected CD34 cells from his HLA two-loci mismatched mother.	10483141
Graft-vs-Host Disease, Virus Diseases, Thrombomodulin Alfa	Stem Cell Exhaustion	Stem cell transplantation using CD34 positively selected cells from HLA-mismatched related donors may be a useful treatment with low incidence of severe GVHD, but many problems remain to be overcome, including severe viral infections and TMA.	10483141
Peripheral Blood Stem Cells, Hematologic Neoplasms	Stem Cell Exhaustion	All patients enrolled in the study had hematological malignancies and underwent high-dose therapy with peripheral blood stem cell (PBSC) support.	10483819
Adult chronic idiopathic neutropenia	Stem Cell Exhaustion	Low frequency of myeloid progenitor cells in chronic idiopathic neutropenia of adults may be related to increased production of TGF-beta1 by bone marrow stromal cells.	10485270
Peripheral Blood Stem Cells	Stem Cell Exhaustion	In order to assess the potential clinical benefit of filgrastim (G-CSF) after peripheral blood stem cell (PBSC) autotransplantation a randomized study was begun in our center in July 1997: 62 patients were involved (30 received filgrastim after PBSC infusion and 32, the control group, received no cytokines).	10490724
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	The purpose of this paper was to (1) comprehensively analyze transplant-related costs for predicted temporal cost shifting and (2) to evaluate whether previous findings of decreasing costs of care persisted using a cost analysis of 353 NHL patients who received autologous stem cell transplantation (SCT) at the University of Nebraska Medical Center.	10490736
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	A graft-versus-myeloma effect has been previously induced by infusing high numbers of donor lymphocytes after allogeneic stem cell transplantation in relapsed/refractory multiple myeloma (MM) patients.	10490737
Small cell carcinoma of lung	Stem Cell Exhaustion	Circulating progenitor cell release and functional characterization after topotecan plus G-CSF and erythropoietin in small cell lung cancer patients.	10493966
Neoplasms, "cytidylyl-(3-5)-cytidine	Stem Cell Exhaustion	As a part of our ongoing attempt to optimize the use of disease-specific drugs as circulating progenitor cell (CPC) priming in solid tumors, we have evaluated the effects on CPC release of single-agent Topotecan followed by granulocyte colony-stimulating factor (G-CSF) + human recombinant erythropoietin (rhEPO), together with the cell cycle status of the collected CD34+ cells.	10493966
BCR gene	Stem Cell Exhaustion	Between March 1980 and March 1997, 314 eligible adults with primary refractory (24%) or primary relapsed (76%) ALL were treated with various chemotherapy or stem cell transplantation (SCT) regimens.	10506707
Hodgkin Disease	Stem Cell Exhaustion	High-dose BEAM chemotherapy with autologous haemopoietic stem cell transplantation for Hodgkin's disease is unlikely to be associated with a major increased risk of secondary MDS/AML.	10507773
Acute Myeloid Leukemia with Myelodysplasia-Related Changes	Stem Cell Exhaustion	High-dose therapy with autologous stem cell support has become the standard salvage therapy for patients failing chemotherapy, but there have been reports of a high incidence of myelodysplasia/acute myeloid leukaemia (MDS/AML) following such treatment.	10507773
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	In patients where hematopoiesis was predominantly derived from the PNH stem cell, absolute numbers of both naive PNH CD4(+) cells and CD8(+) cells show an inverse correlation with patient age, implying this age-related decline in T-cell production is secondary to a decrease in thymic activity rather than a stem cell defect.	10515882
Optic Nerve	Stem Cell Exhaustion	The purpose of this study was to prospectively evaluate the retinal and optic nerve changes in patients undergoing high-dose chemotherapy (HDC) followed by autologous hematopoietic progenitor cell support (AHPCS).	10516683
Venoocclusive disease	Stem Cell Exhaustion	Late onset veno-occlusive disease following high-dose chemotherapy and stem cell transplantation.	10516702
Hepatic Veno-Occlusive Disease, Venoocclusive disease	Stem Cell Exhaustion	The original definition of hepatic veno-occlusive disease (VOD), which is still widely accepted, includes onset of the clinical syndrome before day +20 following high-dose chemotherapy (HDC) and stem cell transplantation (SCT).	10516702
Pneumocystis jiroveci pneumonia, Toxic effect	Stem Cell Exhaustion	A prospective randomized trial comparing the toxicity and safety of atovaquone with trimethoprim/sulfamethoxazole as Pneumocystis carinii pneumonia prophylaxis following autologous peripheral blood stem cell transplantation.	10516703
Pneumocystis carinii, Pneumonia	Stem Cell Exhaustion	Pneumonia due to Pneumocystis carinii is an infrequent complication following autologous stem cell transplantation (ASCT) which is associated with a high mortality.	10516703
Antipneumocystis Agent	Stem Cell Exhaustion	We have conducted a prospective randomized trial comparing atovaquone, a new anti-Pneumocystis agent, with TMP/SMX for PCP prophylaxis following autologous peripheral blood stem cell (PBSC) transplantation.	10516703
Waldenstrom Macroglobulinemia	Stem Cell Exhaustion	Autologous peripheral blood stem cell transplantation for Waldenstrom's macroglobulinemia.	10516708
Hemoglobinuria, Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	Paroxysmal nocturnal haemoglobinuria (PNH) cells are deficient in glycosylphosphatidylinositol (GPI) linked antigens due to a somatic mutation of the PIG-A gene in a haemopoietic stem cell.	10520035
Stem Cell Factor	Stem Cell Exhaustion	The levels of thrombopoietin (TPO), interleukin-6 (IL-6), soluble IL-6 (sIL-6) receptor, IL-11, stem cell factor (SCF), IL-3, and IL-8 were determined by enzyme-linked immunosorbent assay (ELISA).	10521086
BCR gene	Stem Cell Exhaustion	Nevertheless, it is hypothesized that sunlight deprivation in the arctic winter can lead to a deficiency of the 1, 25(OH)2D3 vitamin, which might stimulate leukemic cell proliferation and block cell differentiation through dysregulation of growth factors in the bone marrow stromal cells, causing one mutation and an overt ALL in progenitor cells damaged during the current or the previous winter by influenza virus, the other mutation.	10525828
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Estimation of the target stem-cell population size in chronic myeloid leukemogenesis.	10525957
Radiation-Induced Cancer, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Estimation of the number of hematopoietic stem cells capable of causing chronic myeloid leukemia (CML) is relevant to the development of biologically based risk models of radiation-induced CML.	10525957
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Through a comparison of the age structure of CML incidence data from the Surveillance, Epidemiology, and End Results (SEER) Program and the age structure of chromosomal translocations found in healthy subjects, the number of CML target stem cells is estimated for individuals above 20 years of age.	10525957
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Finally, assuming that translocations are equally likely to occur between any two points in the genome, the parameter estimates found in the first two steps are used to estimate the number of target stem cells for CML.	10525957
Childhood Breast Carcinoma	Stem Cell Exhaustion	Factors correlated with progression-free survival after high-dose chemotherapy and hematopoietic stem cell transplantation for metastatic breast cancer.	10527180
Childhood Breast Carcinoma	Stem Cell Exhaustion	Women with breast cancer are the most frequent recipients of high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (autotransplants) in North America.	10527180
Histiocytic Disorders, Malignant	Stem Cell Exhaustion	We followed 253 consecutive patients with malignant disorders who received autologous transplants after stem cell harvest followed by 12 mg/kg busulfan, 100 mg/m2 melphalan, and 500 mg/m2 thiotepa.	10534061
Osteoporosis	Stem Cell Exhaustion	We conclude that in osteoporosis stem cell growth, proliferative response and osteogenic differentiation are significantly affected.	10536365
Osteoporotic Fractures	Stem Cell Exhaustion	Abnormal osteogenesis in osteoporotic patients is reflected by altered mesenchymal stem cells dynamics.	10536365
Osteoporotic Fractures	Stem Cell Exhaustion	The goal of this study was to compare the functional characteristics of mesenchymal stem cells derived from "healthy" control and osteoporotic postmenopausal women to better understand the mechanisms involved in the pathogenesis of this disease.	10536365
Osteoporotic Fractures	Stem Cell Exhaustion	Osteoporotic and control stem cells have similar morphology and size and express similar cell surface antigens as evidenced by their reactivity with cell specific monoclonal antibodies.	10536365
Osteoporotic Fractures	Stem Cell Exhaustion	Mesenchymal stem cells from osteoporotic women differ from controls in having a lower growth rate than control cells, being refractory to the mitogenic effect of IGF-1, and exhibiting a deficient ability to differentiate into the osteogenic linage as evidenced by the alkaline phosphatase activity and calcium phosphate deposition.	10536365
Osteoporosis, Osteoporotic Fractures	Stem Cell Exhaustion	Also, the study of mesenchymal stem cells from osteoporotic postmenopausal women may provide a better understanding of the mechanisms involved in the pathogenesis of the osteoporosis.	10536365
Myeloid Leukemia	Stem Cell Exhaustion	HuM195 is a recombinant humanized IgG1 monoclonal antibody reactive with CD33, a Mr 67,000 glycoprotein expressed on early myeloid progenitor cells and myeloid leukemia cells.	10537338
Childhood Breast Carcinoma, Thymus Hyperplasia	Stem Cell Exhaustion	Thymic hyperplasia after high-dose chemotherapy and autologous stem cell transplantation: incidence and significance in patients with breast cancer.	10541115
Childhood Breast Carcinoma, Thymus Hyperplasia	Stem Cell Exhaustion	The purpose of this study was to determine the incidence and clinical significance of thymic hyperplasia after high-dose chemotherapy and autologous stem cell transplantation for treatment of metastatic or high-risk primary (with at least four positive lymph nodes) breast cancer.	10541115
Childhood Breast Carcinoma	Stem Cell Exhaustion	We retrospectively reviewed clinical records and CT scans of 102 breast cancer patients treated with high-dose chemotherapy and autologous stem cell transplantation.	10541115
Childhood Breast Carcinoma, Thymus Hyperplasia	Stem Cell Exhaustion	Thymic hyperplasia is rare after high-dose chemotherapy and autologous stem cell transplantation in adult patients with metastatic or high-risk primary breast cancer.	10541115
Small cell carcinoma of lung	Stem Cell Exhaustion	We report the preliminary results of a Phase I/II trial of RIT in SCLC using a two-step method and a myeloablative protocol with circulating stem cells transplantation.	10541373
Medullary carcinoma of thyroid	Stem Cell Exhaustion	Nine radioimmunotherapy (RAIT)-naive patients with medullary thyroid cancer received high doses of 131I-MN-14 F(ab)2 anti-carcinoembryonic antigen monoclonal antibody (232-486 mCi), five in combination with bone marrow harvest, without prior granulocyte colony stimulating factor (G-CSF) injections (group 1) and the other four using peripheral blood stem cell harvest (PBSCH) preceded by G-CSF administration of 10 microg/kg per day for 5 days for stem cell mobilization, 6-8 days before RAIT (group 2).	10541383
White Blood Cell Count procedure	Stem Cell Exhaustion	The difference in WBC toxicity after RAIT with bone marrow harvest and PBSCH is thought to be due to the administration of G-CSF for stem cell mobilization within 1 week before RAIT, which may sensitize the "endogenous" granulocyte precursors to subsequent RAIT.	10541383
Peripheral Stem Cell Transplantation, Carcinoma, Transitional Cell	Stem Cell Exhaustion	High dose chemotherapy for refractory urothelial carcinoma supported by peripheral blood stem cell transplantation.	10547557
Childhood Breast Carcinoma	Stem Cell Exhaustion	To determine if inhibition of stem-cell activity induced by granulocyte-macrophage colony-stimulating factor ([GM-CSF]; Sargramostim; Immunex Corporation, Seattle, WA) withdrawal or priming protects hematopoietic stem cells from the cytotoxic effects of adjuvant chemotherapy for early-stage breast cancer.	10550137
Small cell carcinoma of lung	Stem Cell Exhaustion	Multiple courses of high-dose ifosfamide, carboplatin, and etoposide with peripheral-blood progenitor cells and filgrastim for small-cell lung cancer: A feasibility study by the European Group for Blood and Marrow Transplantation.	10550151
Small cell carcinoma of lung	Stem Cell Exhaustion	To determine the feasibility and safety of multiple sequential courses of high-dose chemotherapy and peripheral-blood progenitor cells (PBPCs) administered in a multicenter setting to patients with small-cell lung cancer.	10550151
Neoplasms	Stem Cell Exhaustion	Our results provide strong evidence that the follicular and medullary components in MMFCs are not derived from a single progenitor cell, because the seven tumors amenable for analysis consistently exhibited a different pattern of mutations, allelic losses, and clonal composition.	10550306
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Assessment of distribution of CD34 epitope classes in fresh and cryopreserved peripheral blood progenitor cells and acute myeloid leukemic blasts.	10553156
Stage III Non-Hodgkin Lymphoma	Stem Cell Exhaustion	In order to analyze the effects of freezing/thawing procedures (Eth 80C storage for 3 months) and use of dimethylsulfoxide (DMSO) on the immunophenotype profile and colony production of peripheral blood progenitor cells (PBPC) in apheresis products derived from 20 patients with stage 0-III non-Hodgkin's lymphoma (nHL), a flow cytometry study was undertaken using different CD34 monoclonal antibodies (MoAbs) capable of recognizing the 3 epitope classes of CD34 molecule (class III: HPCA-2/FITC, HPCA-2/PE, 581/FITC, 581/PE; class II: Q-Bend 10/PE; class I: ICH3/PE, BI3C5-PE, Immu-133-PE).	10553156
Sepsis	Stem Cell Exhaustion	One patient in an advanced stage of disease died after the administration of a high-dose regimen of melphalan with blood stem-cell support subsequent to sepsis.	10554513
S100A4 protein, human	Stem Cell Exhaustion	The detection of leukaemia-associated genetic markers in CD34-positive progenitor cells in a subset of B-CLL patients suggests that malignant transformation in B-CLL occurs in an immature progenitor cell compartment.	10554806
Waldenstrom Macroglobulinemia	Stem Cell Exhaustion	High-dose therapy with autologous haemopoietic stem cell support for Waldenstrom's macroglobulinaemia.	10554812
Peripheral Blood Stem Cells	Stem Cell Exhaustion	We have evaluated the feasibility, safety and efficacy of high-dose chemotherapy with peripheral blood stem cell support in six patients aged 45-69 years (median 51.5) with WM; four patients relapsed after prior therapy inclusive of purine analogues and two patients proceeded with transplant after minimal therapy.	10554812
Hematologic Neoplasms	Stem Cell Exhaustion	Peripheral blood progenitor cells are now commonly used for hematologic reconstitution after myelosuppressive chemotherapy for hematologic and solid malignancies.	10556954
Hematologic Neoplasms	Stem Cell Exhaustion	213 consecutive, afebrile adult patients treated with or without autologous stem cell transplantation for haematological malignancies.	10560360
Neutropenia, Hematologic Neoplasms, Mycoses	Stem Cell Exhaustion	In neutropenic patients treated for haematological malignancies with or without autologous stem cell transplantation, fluconazole and itraconazole in low doses result in a similar low frequency of fungal disease.	10560360
Thrombocytosis, Myeloproliferative disease, Primary Myelofibrosis, Polycythemia Vera, DPM1 gene	Stem Cell Exhaustion	The myeloproliferative disorders (MPDs) are clonal disorders of the hematopoietic stem cell and classified as polycythemia vera (PV), essential thrombocythemia (ET), or agnogenic myeloid metaplasia (AMM), depending on the main hematopoietic lineage involved.	10561146
Small cell carcinoma of lung, Limited Stage Lung Small Cell Carcinoma	Stem Cell Exhaustion	To determine progression-free survival (PFS) and overall long-term survival for limited-stage small-cell lung cancer (SCLC) patients aged 60 years or younger who respond to first-line chemotherapy followed by high-dose combination alkylating agents (cyclophosphamide 5,625 mg/m(2), cisplatin 165 mg/m(2), and carmustine 480 mg/m(2)) with hematologic stem-cell support and chest and prophylactic cranial radiotherapy.	10561176
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Successful treatment of metastatic renal cell carcinoma with a nonmyeloablative allogeneic peripheral-blood progenitor-cell transplant: evidence for a graft-versus-tumor effect.	10561256
Myeloid	Stem Cell Exhaustion	Serial polymerase chain reaction analysis of hematopoietic lineage-specific minisatellites initiallyshowed mixed chimerism in CD14(+) and CD15(+) myeloid cells, CD3(+) T cells, and CD34(+) progenitor cells, with rapid conversion to 100% donor T-cell chimerism by day +60 and 100% donor myeloid cells by day +100.	10561256
Multiple Myeloma	Stem Cell Exhaustion	To evaluate high-dose melphalan followed by autologous stem-cell transplantation in patients with refractory multiple myeloma.	10561273
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	This 60-year-old man with non-Hodgkin's lymphoma (diffuse large B-cell lymphoma) demonstrated disease recurrence in the liver and the vertebrae following high-dose chemotherapy and autologous hematopoietic stem cell transfusion.	10561911
Peripheral Stem Cell Transplantation, Virus Diseases	Stem Cell Exhaustion	Frequent viral infections and delayed CD4+ cell recovery following CD34+ cell-selected autologous peripheral blood stem cell transplantation.	10561914
Infection	Stem Cell Exhaustion	This study compares the reconstitution of T-lymphocyte subsets and the incidence of infections following CD34+ cell-selected autologous peripheral blood stem cell transplantation (PBSCT) (n = 15) and unselected auto-PBSCT (n = 16).	10561914
Small cell carcinoma of lung, Extensive Stage Lung Small Cell Carcinoma	Stem Cell Exhaustion	We report a 62-year-old male with extensive disease small-cell lung cancer (SCLC) who was successfully treated with double high-dose chemotherapy supported by autologous peripheral blood stem cell transplantation (auto-PBSCT).	10563752
Toxic effect, Neoplasms	Stem Cell Exhaustion	After the peripheral blood stem cell mobilization, two cycles of high-dose ICE regimen (ifosfamide 3,000 mg/m2 at days 1 to 5, carboplatin 400 mg/m2 at days 1, 3, 5, and etoposide 500 mg/m2 at days 1, 3, 5) could be given with further regression of the tumor and acceptable toxicities.	10563752
Small cell carcinoma of lung	Stem Cell Exhaustion	Double high-dose chemotherapy supported by autologous transplantation of peripheral blood stem cells for treatment of an elderly patient with small-cell lung cancer.	10563752
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	[An early phase II study of autologous peripheral blood stem cell transplantation for acute myelogenous leukemia in first remission.	10565221
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We performed a multicenter, an early phase II clinical trial to evaluate the feasibility, safety and efficacy of myeloablative therapy supported by autologous peripheral blood stem cell transplantation (auto-PBSCT) for the treatment of acute myelogenous leukemia (AML) in first remission.	10565221
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	[A multicenter early phase II study of high-dose chemotherapy with autologous peripheral blood stem cell transplantation for treatment of intermediate-grade non-Hodgkin's lymphoma.	10565222
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	We conducted a multicenter early phase II study to evaluate the feasibility and therapeutic efficacy of high-dose chemotherapy supported by autologous peripheral blood stem cell transplantation (auto-PBSCT) for the treatment of intermediate grade non-Hodgkin's lymphoma (IG-NHL).	10565222
Dystrophy	Stem Cell Exhaustion	In contrast to what is still written in most textbooks, both dystrophies have their origin in the epithelium, which originates from the limbal stem cells.	10571296
Immunology	Stem Cell Exhaustion	After surgery, cyclosporin A was administered for at least 6 months to protect the limbal stem cells from immunologic destruction.	10571296
Dystrophy	Stem Cell Exhaustion	Follow-up must occur for many years before we will definitely know under which conditions long-term survival of donor stem cells occurs to such an extent that subepithelial recurrences in granular and lattice dystrophies stop being a major problem after keratoplasty in these patients.	10571296
Small cell carcinoma of lung	Stem Cell Exhaustion	A 40-year old patient with small cell lung cancer (SCLC) was treated with combined modalities including high-dose chemotherapy with subsequent autologous peripheral blood progenitor cell transplantation plus adjuvant radiotherapy.	10573143
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	To evaluate a chemotherapy regimen that consisted of ifosfamide administered as an infusion with bolus carboplatin, and etoposide (ICE) supported by granulocyte colony-stimulating factor (G-CSF) for cytoreduction and stem-cell mobilization in transplant-eligible patients with primary refractory or relapsed non-Hodgkin's lymphoma (NHL).	10577849
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Ifosfamide, carboplatin, and etoposide: a highly effective cytoreduction and peripheral-blood progenitor-cell mobilization regimen for transplant-eligible patients with non-Hodgkin's lymphoma.	10577849
Graft-vs-Host Disease, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Cyclosporine-induced autologous graft-versus-host disease in patients with acute myeloid leukemia undergoing non-myeloablative chemotherapy without progenitor cell reinfusion.	10578157
Acute leukemia, Leukemia, Myelocytic, Acute, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	To determine the incidence and severity of cyclosporine-induced graft-versus-host disease following non-myeloablative chemotherapy without progenitor cell reinfusion in patients with acute leukemia, 17 adults with refractory acute myeloid leukemia (14) or blastic phase of chronic myeloid leukemia (3) were treated with etoposide 2400 mg/m2 and cyclophosphamide 120 mg/kg followed by cyclosporine (CsA) 2.5 mg/kg i.v.	10578157
Pregnancy Complications, Infectious	Stem Cell Exhaustion	Infectious complications after autologous peripheral blood progenitor cell transplantation followed by G-CSF.	10578158
Pregnancy Complications, Infectious	Stem Cell Exhaustion	Infectious complications after autologous peripheral blood progenitor cell transplantation (PBPCT) have been reported in a few studies including small patient numbers.	10578158
Hematological Disease	Stem Cell Exhaustion	Itraconazole oral solution as antifungal prophylaxis in children undergoing stem cell transplantation or intensive chemotherapy for haematological disorders.	10578159
Retinitis Pigmentosa	Stem Cell Exhaustion	Furthermore, significant positive correlations were observed between frequencies of RP and LP in control, ITP and LC subjects, in whom bone marrow stem cells are intrinsically normal.	10580560
Specialty Type - cancer	Stem Cell Exhaustion	The essence of the model, which is highly idealized, is that: (a) a cancer is caused by mutations that accumulate in a stem cell throughout life, essentially the Armitage-Doll multistage model, and (b) radiation is a general mutagen that can cause virtually any of these mutations.	10581535
Multiple Myeloma	Stem Cell Exhaustion	TLS has been described in eight cases of multiple myeloma undergoing high-dose therapy with autologous stem cell transplant (ASCT).	10583230
Amyloidosis	Stem Cell Exhaustion	Recently, clinical trials of intensive chemotherapy followed by autologous or allogeneic stem cell support has been shown to offer potential benefit in AL (amyloid light-chain) amyloidosis.	10583230
Neoplasms	Stem Cell Exhaustion	Sequential positive and negative enrichment of stem cells reduced tumour cell contamination in B-cell malignancies below the lower limit of detection of molecular analysis.	10583236
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	These findings suggest that familial CLL cases may preferentially derive from B-cell progenitors that have responded to antigen.	10583268
IgG myeloma	Stem Cell Exhaustion	Between May 1989 and December 1997, 177 consecutive patients with IgG myeloma who were <75 years old were seen, of whom 153 entered a sequential therapy (ST) programme of initial courses of C-VAMP infusional chemotherapy (IC), high-dose treatment (with or without stem cell rescue) (119 patients) and maintenance interferon (87 patients).	10583272
Bone Marrow Dysplasia Present	Stem Cell Exhaustion	Since alkylating agents often induce profound marrow dysplasia, long-lived lesions induced on hematopoietic stem cells are of potential relevance to the development of SL.	10584563
Primary malignant neoplasm	Stem Cell Exhaustion	A predictive model for relapse in high-risk primary breast cancer patients treated with high-dose chemotherapy and autologous stem-cell transplant.	10589754
Febrile Neutropenia	Stem Cell Exhaustion	Empiric antimicrobial therapy of febrile neutropenic patients undergoing haematopoietic stem cell transplantation.	10595571
Febrile Neutropenia	Stem Cell Exhaustion	ceftazidime and ciprofloxacin in neutropenic febrile patients undergoing high dose myeloablative therapy and hematopoietic stem cell transplantation (HSCT).	10595571
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Characterisation of the differential response of normal and CML haemopoietic progenitor cells to macrophage inflammatory protein-1alpha.	10602423
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Hematopoietic progenitor cell-derived DNA analysis revealed that, in two of the three persons there were 2 apparently distinct progenitor cell lineages whose percentages were close to those in the peripheral blood of the patients, as analyzed by flow cytometry; the exception was Subject 3, who had myelodysplastic syndrome (MDS).	10604253
PAFAH1B1 wt Allele	Stem Cell Exhaustion	The subject with MDS was assumed to have an ABO mosaicism caused by the somatic deletion of the ABO gene in the hematopoietic progenitor cells.	10604253
Hemoglobinuria	Stem Cell Exhaustion	These findings indicate that NT4.2 exerts its cytotoxicity through a perforin-mediated pathway, not a Fas/Fas ligand-dependent pathway, and that haemopoietic stem cells lacking CD59 may evade cytotoxic T lymphocytes, leading to the in vivo expansion of a paroxysmal nocturnal haemoglobinuria clone.	10606886
Aplastic Anemia, Hypoplasia	Stem Cell Exhaustion	In the aplastic anaemia bone marrow compartment we postulate that accessory cells down-regulate TGF-beta1 expression to allow stem cell cycling to counteract hypoplasia.	10606887
Aplastic Anemia, Hematopoiesis	Stem Cell Exhaustion	As TGF-beta1 is important in the regulation of haemopoiesis, dysregulation of this cytokine in combination with previously described abnormal cytokine expression may contribute significantly to the pathophysiology of aplastic anaemia by exacerbating primary stem cell defects.	10606887
Multiple Myeloma	Stem Cell Exhaustion	Impact on survival of high-dose therapy with autologous stem cell support in patients younger than 60 years with newly diagnosed multiple myeloma: a population-based study.	10607678
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	A poor prognostic group of patients with refractory or recurrent aggressive lymphoma, many of whom were not eligible for high-dose therapy and stem cell transplantation were treated with repeated cycles of dose intensified DHAP with growth factor support.	10609790
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Peripheral progenitor cells (CFU-GM, BFU-E, CD34) are increased in untreated chronic lymphocyte leukemia patients: stage B and C display a particularly high CD34+ cell count.	10609796
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	We assayed progenitor cells (CFU-GM, BFU-E, CD34) in the peripheral blood of 28 untreated CLL patients and found an increase of all these progenitors in CLL compared to controls.	10609796
CLU protein, human	Stem Cell Exhaustion	Salvage CLI may not necessarily compromise future treatment with chemotherapy, including autologous bone marrow or stem cell transplantation, because the patients' blood counts recover.	10613314
Neoplasms	Stem Cell Exhaustion	Afterwards external radiotherapy of the primary tumor site was performed and polychemotherapy was continued, followed by autologous peripheral blood stem cell reinfusion.	10615669
Osteosarcoma	Stem Cell Exhaustion	The present case warrants further evaluation of feasibility and efficacy of this multimodal therapy combination of high-activity Sm-153-EDTMP therapy, external radiation, polychemotherapy and stem cell support for unresectable osteosarcomas.	10615669
Non-Small Cell Lung Carcinoma, Neoplasms	Stem Cell Exhaustion	Stem cell factor and granulocyte-macrophage-colony stimulating factor as candidates for tumour markers for non-small-cell lung cancer.	10616749
Neoplasms, Stem Cell Factor	Stem Cell Exhaustion	We have investigated the serum level of stem cell factor (SCF) and granulocyte-macrophage-colony stimulating factor (GM-CSF) in relation to a control group and commonly accepted tumour markers, such as carcinoembryonic antigen (CEA) and cytokeratin fragment 19 (CYFRA 21-1).	10616749
Multiple Myeloma	Stem Cell Exhaustion	Reduced bone marrow stem cell pool and progenitor mobilisation in multiple myeloma after melphalan treatment.	10618687
melphalan/prednisone protocol	Stem Cell Exhaustion	The clonogenicity as well as the ability to expand the marrow stem cell pool during growth factor treatment were also reduced in MP treated patients compared to untreated patients.	10618687
Multiple Myeloma	Stem Cell Exhaustion	The content of stem cells was analysed in bone marrow samples from 75 multiple myeloma patients.	10618687
melphalan/prednisone protocol	Stem Cell Exhaustion	Analysis of different subsets of CD34+ cells revealed no influence on the pre B cell compartment in the bone marrow by MP treatment, but the committed stem cells (CD34+CD38+) were reduced more than the uncommitted stem cells (CD34+CD38-) in the MP treated group compared to the untreated patients.	10618687
Chronic myeloproliferative disorder, LINC01152 gene	Stem Cell Exhaustion	Chronic myeloproliferative disorders (CMPD) originate from a pluripotent haematopoietic progenitor cell but show a marked degree of heterogeneity, especially between Philadelphia chromosome positive and negative disease entities.	10621836
Carcinogenesis	Stem Cell Exhaustion	Thus, normal HBECs do have a low level of telomerase activity, and Type I HBECs with stem cell characteristics are more susceptible to telomerase activation and immortalization, a basis on which they may be major target cells for breast carcinogenesis.	10626801
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Successful peripheral blood stem cell transplantation for myelodysplastic syndrome.	10627645
Anemia	Stem Cell Exhaustion	A 47-year-old man given a diagnosis of refractory anemia with excess of blasts in transformation (RAEB-T) received myeloablative therapy followed by autologous peripheral blood stem cell transplantation (PBSCT).	10627645
Hodgkin Disease	Stem Cell Exhaustion	Morphologically normal, CD30-negative B-lymphocytes with chromosome aberrations in classical Hodgkin's disease: the progenitor cell of the malignant clone?	10629553
Intravascular hemolysis, Venous Thrombosis, Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal disease of the hemopoietic stem cell (HSC) characterized by intravascular hemolysis and increased risk of venous thrombosis.	10629593
leukemia	Stem Cell Exhaustion	We now demonstrate that the HPRT gene can be utilized to detect mutations in myeloid stem cells, which are frequent progenitor cells of leukemias.	10635986
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Increases in M-MF are seen as expected in the clonally unstable myeloid stem cells of patients with myelodysplastic syndromes; however, unexpectedly these patients also have elevated T-lymphocyte mutant frequencies (T-MF).	10635986
Neoplasms	Stem Cell Exhaustion	We sought to link the BRCA2 mutation to the pathogenesis of this tumor as well as to determine whether both histologic components arose from the same progenitor cell.	10637076
Hereditary Ovarian Carcinoma, Neoplasms	Stem Cell Exhaustion	These data indicate that hereditary ovarian carcinosarcoma may result from a mutation in BRCA2 and that both histologic elements of this tumor arose from the same progenitor cell.	10637076
BCR gene	Stem Cell Exhaustion	This well-tolerated IFN-containing maintenance treatment could be considered to reinforce intensified programs based on autologous stem cell transplantation as an alternative to allogeneic transplantation in P190BCR-ABL+ ALL patients (and by extension for Ph+ ALL patients) lacking an HLA-matched donor.	10637472
Neoplasms	Stem Cell Exhaustion	Ten of the tumours exhibited two non-diploid stem cell lines.	10640904
Acute leukemia	Stem Cell Exhaustion	In this study of autotransplantation for acute leukemia using mafosfamide-purged marrow, the stem cell dose used for purging and the intensity of purging were the most important factors predicting outcome.	10641600
Failure, Transplant-Related Malignant Neoplasm	Stem Cell Exhaustion	However, they also identified some transplant difficulties, such as failure to collect sufficient numbers of stem cells, slow kinetics of engraftment, and a high transplant-related mortality that diminished or negated positive impact on overall survival.	10641600
Immunologic Deficiency Syndromes	Stem Cell Exhaustion	Accelerated phase in partial albinism with immunodeficiency (Griscelli syndrome): genetics and stem cell transplantation in a 2-month-old girl.	10653334
Hypertriglyceridemia, Hypopigmentation-immunodeficiency disease, Cessation of life, Fever, Pancytopenia	Stem Cell Exhaustion	The silvery-greyish hair associated with fever, pancytopenia and hypertriglyceridaemia is the clue to early diagnosis of Griscelli syndrome and important to prevent death before stem cell transplantation.	10653334
Peripheral Blood Stem Cells, Small cell carcinoma of lung	Stem Cell Exhaustion	A phase I dose escalation study of multicyclic, dose-intensive chemotherapy with peripheral blood stem cell support for small cell lung cancer.	10654007
Hematological Disease	Stem Cell Exhaustion	Between October 1995 and October 1998, 24 children aged 9 months to 17 years (median 11 years) underwent cytokine-mobilized allogeneic peripheral blood stem cell (PBSC) transplantation for treatment of hematological disorders.	10654008
Breast Carcinoma	Stem Cell Exhaustion	High-dose cyclophosphamide + carboplatin and interleukin-2 (IL-2) activated autologous stem cell transplantation followed by maintenance IL-2 therapy in metastatic breast carcinoma - a phase II study.	10654009
mecarzole, Childhood Breast Carcinoma	Stem Cell Exhaustion	While high-dose chemotherapy and stem cell transplantation is associated with higher complete response rates than conventional chemotherapy in patients with metastatic breast cancer (MBC), its role in conferring a survival advantage is unproven.	10654009
Morular Metaplasia of the Endometrium	Stem Cell Exhaustion	Peripheral blood progenitor cell (PBPC) collections have been widely used to support high-dose therapy for MM patients.	10654010
Hodgkin Disease	Stem Cell Exhaustion	Autologous stem cell transplantation for advanced Hodgkin's disease in children.	10654011
Hodgkin Disease, HD Term Type	Stem Cell Exhaustion	This study evaluates the outcome of myeloablative chemo-radiotherapy and autologous stem cell transplantation (ASCT) in children with Hodgkin's disease (HD).	10654011
HD Term Type	Stem Cell Exhaustion	High-dose therapy with stem cell rescue can lead to durable remissions in children with advanced HD.	10654011
Nervous System Physiological Phenomena, Multiple Organ Failure	Stem Cell Exhaustion	Central nervous system dysfunction as the first manifestation of multiple organ dysfunction syndrome in stem cell transplant patients.	10654019
Cessation of life, physiopathological, Organ Dysfunction Scores	Stem Cell Exhaustion	Development of CNS dysfunction in the setting of hematopoietic stem cell transplant (HSCT) has been previously shown to predict for subsequent second organ dysfunction and death.	10654019
Organ Dysfunction Scores	Stem Cell Exhaustion	The patients who progressed to second organ dysfunction and those who did not were not different in terms of type of HSCT (allogeneic vs autologous), stem cell source (blood vs bone marrow), age, diagnosis or preparative regimen.	10654019
PAFAH1B1 wt Allele	Stem Cell Exhaustion	On the other hand, lymphoid MDS-derived cell lines may attest to the clonal nature of MDS which may afflict progenitor cells giving rise to lymphoid or myelomonocytoid cells.	10654445
Primary malignant neoplasm	Stem Cell Exhaustion	Uncontrolled studies have reported encouraging outcomes for patients with high-risk primary breast cancer treated with high-dose chemotherapy and autologous hematopoietic stem cell support.	10655439
Atrophic, leukemia	Stem Cell Exhaustion	Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy.	10657672
Myasthenias	Stem Cell Exhaustion	LIF, oncostatin M (OSM), IL-6, M-CSF, and stem cell factor (SCF) mRNA were elevated in normal and myasthenia gravis-aged thymuses, and correlated with decreased levels of thymopoiesis, as determined by either decreased keratin-positive thymic epithelial space or decreased thymic sjTRECs.	10657672
Toxic effect, Childhood Breast Carcinoma	Stem Cell Exhaustion	We determined the dose-limiting toxicity and maximum tolerated dose of subcutaneous IL-2 given with G-CSF for PBPC mobilization, the ability of IL-2 + G-CSF mobilized stem cells to reconstitute hematopoiesis, and the in vitro immunologic function of the graft in patients with advanced breast cancer.	10658681
Childhood Breast Carcinoma	Stem Cell Exhaustion	Enhancement of the anti-tumor activity of a peripheral blood progenitor cell graft by mobilization with interleukin 2 plus granulocyte colony-stimulating factor in patients with advanced breast cancer.	10658681
Neutropenia, Decreased platelet count	Stem Cell Exhaustion	None of these patients experienced prolonged neutropenia or thrombocytopenia following stem cell reinfusion and nine of them had long-lasting complete or major cytogenetic responses after transplant.	10658682
Neoplasms	Stem Cell Exhaustion	Histological analysis strongly suggested that this tumor originated from a primitive progenitor cell, the ependymoglia or the tanycyte in the lateral ventricle.	10667826
Inflammatory Breast Carcinoma	Stem Cell Exhaustion	High-dose sequential chemotherapy with recombinant granulocyte colony-stimulating factor and repeated stem-cell support for inflammatory breast cancer patients: does impact on quality of life jeopardize feasibility and acceptability of treatment?	10673516
Inflammatory Breast Carcinoma, Toxic effect, Childhood Breast Carcinoma	Stem Cell Exhaustion	This study was designed to investigate the quality of life (QOL) of patients enrolled onto the High-Dose Chemotherapy for Breast Cancer Study Group trial (PEGASE 02), a French pilot multicenter trial of the treatment of inflammatory breast cancer (IBC) aimed at evaluating (1) toxicity and feasibility of sequential high-dose chemotherapy (HDC) with recombinant human granulocyte colony-stimulating factor (filgrastim) and stem-cell support and (2) response to HDC in terms of pathologic response and survival.	10673516
Vancomycin-Resistant Enterococci	Stem Cell Exhaustion	Incidence and outcome of vancomycin-resistant enterococcal bacteremia following autologous peripheral blood stem cell transplantation.	10673672
Bacteremia, Vancomycin-Resistant Enterococci	Stem Cell Exhaustion	A retrospective evaluation of 321 consecutive recipients of high-dose chemotherapy (HDC) and autologous peripheral blood stem cell transplantation (PBSCT) was conducted to ascertain the incidence and outcome of vancomycin-resistant enterococcal (VRE) bacteremia.	10673672
Primary Myelofibrosis	Stem Cell Exhaustion	We report a 38-year-old woman with progressive HES who developed severe myelofibrosis and was treated by allogeneic stem cell transplantation, using peripheral blood (PBSCT) instead of bone marrow as the source of progenitor cells, after conditioning with cytoxan and busulphan.	10673685
Aplastic Anemia	Stem Cell Exhaustion	Syngeneic peripheral blood stem cell transplantation with brief immunosuppression for severe aplastic anemia.	10673710
Aplastic Anemia	Stem Cell Exhaustion	We report the cases of two severe aplastic anemia (SAA) patients who were successfully treated with syngeneic peripheral blood stem cell transplantation (PBSCT) using immunosuppression without high-dose chemotherapy or irradiation for conditioning.	10673710
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Feasibility of high-dose chemotherapy without stem cell support as a first-line treatment for non-Hodgkin's aggressive lymphoma: a pilot study.	10674903
Aggressive course	Stem Cell Exhaustion	This regimen may improve the outcome in cases of aggressive NHL without stem cell support.	10674903
Chronic myeloproliferative disorder	Stem Cell Exhaustion	We studied telomerase regulation and telomere length in hematopoietic progenitor cells from peripheral blood and bone marrow from patients with acute and chronic leukemia and myeloproliferative diseases.	10676644
Chronic Lymphocytic Leukemia, PAFAH1B1 wt Allele	Stem Cell Exhaustion	Compared with hematopoietic progenitor cells from normal donors (n = 108), telomerase activity (TA) was increased 2- to 5-fold in chronic phase (CP)-CML, CLL, PV, and MDS.	10676644
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Altered adhesive interaction between bone marrow (BM) stroma and progenitors in chronic myeloid leukemia (CML) may be in part caused by abnormal expression of cell adhesion molecules (CAMs) on malignant progenitor cells.	10681720
Malignant Neoplasms	Stem Cell Exhaustion	High-dose chemotherapy with autologous bone marrow or peripheral blood stem cell transplantation has gained widespread acceptance for the treatment of certain malignancies.	10683881
Hodgkin Disease, Neoplasms, Lymphoma cells, Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy with autologous stem cell transplantation has become a safe procedure and is considered the treatment of choice for relapsed large cell lymphoma, relapsed Hodgkin's disease, stage II or III multiple myeloma, and germ cell tumours with inadequate response to cisplatin-based chemotherapy.	10683881
Limbal stem cell deficiency	Stem Cell Exhaustion	Autologous limbal transplantation in patients with unilateral corneal stem cell deficiency.	10684837
Stem Cell Factor	Stem Cell Exhaustion	Here, we investigated the MC distribution and the MC proteinase expression in IC together with the tissue expression of the major MC growth factors, stem cell factor (SCF) and interleukin-6 (IL-6).	10688040
Hodgkin Disease, Therapy-Related Acute Myeloid Leukemia, Lymphoma, Non-Hodgkin, Lymphoma, Non-Hodgkin, Familial, HD Term Type, Therapy-related myelodysplastic syndrome	Stem Cell Exhaustion	We analyzed data on 612 patients who had undergone high-dose chemoradiotherapy (HDT) with autologous stem cell rescue for Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL) at the City of Hope National Medical Center, to evaluate the incidence of therapy-related myelodysplasia (t-MDS) or therapy-related acute myeloid leukemia (t-AML) and associated risk factors.	10688812
Pterygium	Stem Cell Exhaustion	Different investigators have recently emphasized the importance of the limbus and its stem cells in the pathogenesis of the pterygium.	10690823
Hematologic Neoplasms	Stem Cell Exhaustion	CD34+ cell dose predicts relapse and survival after T-cell-depleted HLA-identical haematopoietic stem cell transplantation (HSCT) for haematological malignancies.	10691874
Hematologic Neoplasms, leukemia	Stem Cell Exhaustion	Seventy-eight patients with haematological malignancies, received T-cell-depleted stem cell transplants and cyclosporin followed by delayed add-back of donor lymphocytes to prevent leukaemia relapse.	10691874
Primary Myelofibrosis	Stem Cell Exhaustion	A 54-year-old man showed evidence of disease progression and a reduction in donor chimaerism by molecular microsatellite analysis 6 months after an allogeneic peripheral blood stem cell transplant for chronic idiopathic myelofibrosis.	10691877
Metabolic acidosis, Childhood Breast Carcinoma	Stem Cell Exhaustion	Graft failure of autologous peripheral blood stem cell transplantation due to acute metabolic acidosis associated with total parenteral nutrition in a patient with relapsed breast cancer.	10692681
Therapy-related myelodysplastic syndrome, Malignant Neoplasms	Stem Cell Exhaustion	Therapy-related myelodysplasia and secondary acute myelogenous leukemia after high-dose therapy with autologous hematopoietic progenitor-cell support for lymphoid malignancies.	10694543
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin, Therapy-related myelodysplastic syndrome, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	To evaluate the incidence of and risk factors for therapy-related myelodysplasia (tMDS) and secondary acute myelogenous leukemia (sAML), after high-dose therapy (HDT) with autologous bone marrow or peripheral-blood progenitor-cell support, in patients with non-Hodgkin's lymphoma (NHL).	10694543
Varicella Zoster Virus Infection	Stem Cell Exhaustion	[Varicella-zoster virus infection after hematopoietic stem cell transplantation].	10695394
herpesvirus 3, human	Stem Cell Exhaustion	Of 264 patients aged 15 years or more who underwent hematopoietic stem cell transplantation between 1989 and September 1998 at the Tokyo Metropolitan Komagome Hospital, 47 were infected by the varicella-zoster virus (VZV).	10695394
Hematologic Neoplasms	Stem Cell Exhaustion	Allogeneic peripheral blood stem cell transplantation in children with hematologic malignancies from HLA-matched siblings.	10696122
Non-Small Cell Lung Carcinoma, Stem Cell Factor	Stem Cell Exhaustion	[Stem cell factor (SCF) in diagnosis and monitoring of non-small-cell lung cancer].	10697397
Malignant neoplasm of lung, Stem Cell Factor	Stem Cell Exhaustion	Some clinical investigations have shown autologous production of stem cell factor (SCF) in various human cell lines derived from lung cancer and the expression of SCF mRNA in these lines.	10697397
Eye Injuries	Stem Cell Exhaustion	The 2 rabbits that had no reparative surgery following standard ocular surface injury had histology and immunopathology consistent with incomplete corneal epithelial stem cell failure with vascularization and scarring of the ocular surface.	10703147
Ocular surface disease	Stem Cell Exhaustion	To evaluate the potential efficacy for autologous and allogeneic expanded corneal epithelial cell transplants derived from harvested limbal corneal epithelial stem cells cultured in vitro for the management of ocular surface disease.	10703147
Histologic	Stem Cell Exhaustion	Thus, the composite graft consisted of the amniotic membrane from which the original epithelium had been removed without significant histologic damage to the basement membrane, and the expanded corneal epithelial stem cells, which had been applied to and had successfully adhered to the denuded amniotic membrane.	10703147
Burn injury, Corneal epithelial defect	Stem Cell Exhaustion	Limbal stem cell deficiency was due to chemical burns in 4 patients, history of prior surgery extending to the limbus in 2 patients, chronic limbitis with dystichiasis in one patient and persistent corneal epithelial defect after keratoplasty in one case.	10705110
Myelosuppression, Toxic effect	Stem Cell Exhaustion	Although severe, myelosuppression is of short duration and the generally low toxicity enables patients to proceed to successful peripheral blood stem cell harvest and transplantation.	10706458
Epithelial cell count (procedure), Lymphoma	Stem Cell Exhaustion	EPIC is an effective salvage therapy in the majority of patients with relapsed or refractory lymphoma and does not appear to be toxic to stem cells.	10706458
Toxic effect, Lymphoma	Stem Cell Exhaustion	Epic as an effective, low toxicity salvage therapy for patients with poor risk lymphoma prior to beam high dose chemotherapy and peripheral blood progenitor cell transplantation.	10706458
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Our data further suggest that telomere shortening may serve as a surrogate marker of disease progression in patients with CP CML, supporting a mechanistic link between CML stem cell turnover, genetic instability, and malignant evolution in this disease.	10706851
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Autologous stem cell transplantation for acute myeloid leukemia in first remission.	10707999
Toxic effect, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We studied the feasibility, toxicity, and efficacy of a 2-step approach to autologous stem cell transplantation for patients with acute myeloid leukemia in first remission.	10707999
Rheumatoid Arthritis	Stem Cell Exhaustion	Using the multi-color flow cytometric technique, we compared cell surface antigen expression patterns on bone marrow hematopoietic progenitor cells which were isolated as a CD34 positive- CD45 dull positive with low side scatter intensity (CD34(+)CD45(dull+)SSC(low)) population in flow cytogram between RA (n=12) and AA (n=11).	10713334
Rheumatoid Arthritis, PAFAH1B1 wt Allele	Stem Cell Exhaustion	These data suggest that analysis of cell surface antigen expression patterns of CD34(+)CD45(dull+)SSC(low) progenitor cells by multi-color flow cytometry appears to be a useful method for qualitative and quantitative assessment of marrow progenitor states in AA and RA, therefore this method could be helpful for early detection of clonal evolution in MDS.	10713334
Hematologic Neoplasms	Stem Cell Exhaustion	Forty healthy adult donors underwent marrow (BM) as well as peripheral blood (PBSC) stem cell collections for their HLA-identical adult siblings with hematologic malignancies.	10713626
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation after high-dose melphalan for the treatment with multiple myeloma has resulted in prolonged progression-free survival and overall survival in patients under 65 years.	10713631
Malignant Neoplasms	Stem Cell Exhaustion	The purpose of this study was to develop a cost-effective protocol for the mobilization of peripheral blood stem cells (PBSC) in patients with malignancy.	10719808
Carcinosarcoma	Stem Cell Exhaustion	These results indicate that both the carcinomatous and sarcomatous components of carcinosarcoma are derived from a common stem cell.	10720865
Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	LDGL has been described in association with other malignancies, leading to theories of a common abnormal stem cell as well as development of the LDGL as an immune response to a primary tumor.	10721773
HIV-1 Infection Pathway	Stem Cell Exhaustion	HIV-1 infection may also inhibit the production of other hematopoietic lineages, by directly or indirectly suppressing the maturation of multilineage and/or lineage-restricted hematopoietic progenitor cells.	10722435
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	[Characteristics of blood cells during peripheral blood stem cell mobilization following chemotherapy in patients with non-Hodgkin's lymphoma].	10723236
Engraftment syndrome	Stem Cell Exhaustion	An engraftment syndrome in autologous stem cell transplantation related to mononuclear cell dose.	10723584
Toxic effect, Engraftment syndrome	Stem Cell Exhaustion	Engraftment syndrome (ES) is a toxicity of autologous stem cell transplantation that occurs unexpectedly and is occasionally fatal.	10723584
Myeloid	Stem Cell Exhaustion	We hypothesize that the interaction of committed myeloid precursors from the stem cell product with the pulmonary vascular endothelium can be deleterious, especially under the influence of the inflammatory cytokines present at the time of engraftment.	10723584
Thrombosis	Stem Cell Exhaustion	Regional thrombolysis with urokinase for central venous catheter-related thrombosis in patients undergoing high-dose chemotherapy with autologous blood stem cell rescue.	10725979
Thrombosis	Stem Cell Exhaustion	Fifty-one of 300 patients undergoing high-dose chemotherapy with (n = 245) or without (n = 55) autologous stem cell rescue developed central venous catheter-related thrombosis diagnosed by Doppler sonography or contrast venography.	10725979
Thrombosis	Stem Cell Exhaustion	Regional thrombolysis is safe, easy to administer, effective in many instances, less costly than the doses of antifibrinolytic agents required to induce systemic fibrinolysis, and should be considered in patients receiving high-dose chemotherapy with autologous stem cell rescue who develop central venous catheter-related thrombosis.	10725979
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Eighty-two patients with advanced multiple myeloma (MM) were enrolled in 2 sequential clinical studies of 1 or 2 courses of myeloablative therapy with stem cell support.	10733490
BCR gene	Stem Cell Exhaustion	Stem cells (CD34+lin-) were isolated from adult ALL bone marrows and tested for p16(INK4A) expression by immunocytochemistry.	10733508
Specialty Type - cancer	Stem Cell Exhaustion	Leukapheresis collections obtained following one of four mobilization regimens from 90 cancer patients were analyzed for their content of various progenitor cell types including erythroid and granulopoietic colony-forming cells in methylcellulose (total CFC), CFC-megakaryocyte (CFC-Mk), CFC detected after 10, 35 and 56 days in long-term culture (LTC), and total CD34+ cells.	10734292
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	[Hematopoietic stem cell transplantation as salvage treatment in patients with aggressive non-Hodgkin's lymphoma].	10734621
Aggressive Non-Hodgkin Lymphoma, Bleomycin/Cyclophosphamide/Doxorubicin/Prednisolone/Vindesine Regimen	Stem Cell Exhaustion	The indication of early hematopoietic stem cell transplantation (HSCT) in patients with aggressive non-Hodgkin's lymphoma (LNH) is controversial.	10734621
Childhood Breast Carcinoma	Stem Cell Exhaustion	Factors influencing collection and engraftment of CD34+ cells in patients with breast cancer following high-dose chemotherapy and autologous peripheral blood progenitor cell transplantation.	10738978
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Here, we demonstrate that a low concentration of ACR induces the in vitro differentiation of leukemic progenitor cells from patients with MDS.	10739006
Toxic effect, Malignant neoplasm of ovary	Stem Cell Exhaustion	Efficacy and hematologic toxicity of salvage chemotherapy following stem cell-supported high-dose chemotherapy in women with recurrent ovarian cancer.	10739690
Toxic effect, Malignant neoplasm of ovary	Stem Cell Exhaustion	The objective of this study was to determine the efficacy and hematologic toxicity of salvage chemotherapy in patients with recurrent ovarian cancer following high-dose chemotherapy and peripheral blood stem cell transplantation (PBSCT).	10739690
Tumor necrosis	Stem Cell Exhaustion	The highest yield of CD1a(+)/CD14(-) cells could be obtained with stem cell factor, transforming growth factor-beta, tumor necrosis factor-alpha, GM-CSF, and FLT-3-ligand.	10742386
Childhood Breast Carcinoma	Stem Cell Exhaustion	Hematological recovery and peripheral blood progenitor cell mobilization after induction chemotherapy and GM-CSF plus G-CSF in breast cancer.	10745254
Childhood Breast Carcinoma	Stem Cell Exhaustion	In order to determine the effect of GM-CSF plus G-CSF in combination in breast cancer patients receiving an effective induction regimen, we compared hematological recovery and peripheral blood progenitor cell (PBPC) mobilization according to colony-stimulating factor (CSF) support.	10745254
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation in multiple myeloma after VAD and EDAP courses: a high incidence of oligoclonal serum Igs post transplantation.	10745257
Multiple Myeloma	Stem Cell Exhaustion	Thirty-seven patients with multiple myeloma (stage II and III, 65% increased beta2-microglobulin level) were prospectively treated with a median of 3.7 VAD courses (range 2-8) followed by cyclophosphamide (6 g/m2) in conjunction with G-CSF (5 microg/kg filgrastrim (n = 14), or 3.5 microg/kg lenograstrim (n = 22)), and peripheral stem cell (PSC) isolation.	10745257
Malignant neoplasm of testis	Stem Cell Exhaustion	Collection of peripheral blood stem cells with granulocyte-colony-stimulating factor alone in testicular cancer patients.	10750885
Malignant neoplasm of testis	Stem Cell Exhaustion	High-dose chemotherapy with the transplantation of peripheral blood stem cells (PBSC) has been performed for the treatment of advanced testicular cancer patients.	10750885
Malignant neoplasm of testis	Stem Cell Exhaustion	After mobilization of peripheral blood stem cells with G-CSF alone, sufficient amounts of MNC were obtained from testicular cancer patients who had undergone chemotherapy several times.	10750885
Thalassemia, Hemopoietic stem cell transplant	Stem Cell Exhaustion	To examine the feasibility of bone marrow hematopoietic stem cell transplantation for thalassemia major.	10751525
Thalassemia	Stem Cell Exhaustion	This is the first report on successful transplantation of bone marrow stem cell for thalassemia major in China, suggesting a new way to treat the disease and to expand the use of BMT.	10751525
Polycythemia Vera	Stem Cell Exhaustion	Polycythemia vera (PV) is a clonal stem cell disorder characterized by hyperproliferation of the erythroid, myeloid, and megakaryocytic lineages.	10753836
Communicable Diseases	Stem Cell Exhaustion	Whether the infection occurs at the level of the stem cells or subsequently during myeloid cell differentiation is, as yet, unknown.	10756359
PAFAH1B1 wt Allele	Stem Cell Exhaustion	These results suggest that an increase in haemopoietic progenitor cells by ATG may be one of several important mechanisms for haematological recovery in AA and MDS.	10759717
Neoplasms, Basaloid squamous cell carcinoma	Stem Cell Exhaustion	Basaloid squamous carcinoma of the oesophagus is a peculiar neoplasm with a capacity of multidirectional differentiation, often with heterogeneous oncogene expression, probably reflecting the pluripotential stem cell origin.	10759947
melanoma	Stem Cell Exhaustion	Phase I study in melanoma patients of a vaccine with peptide-pulsed dendritic cells generated in vitro from CD34(+) hematopoietic progenitor cells.	10760827
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Mobilization of peripheral blood stem cells by granulocyte-colony stimulating factors: comparison of a standard dose of glycosylated and mutated granulocyte-colony stimulating factor in non-Hodgkin's lymphoma patients following CHOP therapy.	10761530
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	At diagnosis FIt3/ITD and non-mutant AML bone marrow samples did not differ in their progenitor/stem cell frequencies.	10764154
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In this study we compared 18 samples with FIt3/ITDs and 63 AML samples without these mutations with respect to clinical prognosis, cytokine responsiveness, progenitor cell content and repopulation in the NOD/SCID mouse.	10764154
Neoplasms	Stem Cell Exhaustion	I-HDS included: (1) tumor debulking, by 2 APO+2 DHAP courses; (2) sequential administration of high-dose (hd) etoposide, methotrexate, and cyclophosphamide, followed by peripheral blood progenitor cell (PBPC) harvest; (3) hd-mitoxantrone + melphalan with PBPC autograft.	10764164
Graft-vs-Host Disease, Transplant Recipients, Acute GVH disease	Stem Cell Exhaustion	Mycophenolate mofetil (MMF), a new immunosuppressive drug successfully used in renal and heart transplant recipients, was used in combination with cyclosporin A (CsA), methotrexate (MTX) and prednisolone for the prophylaxis of acute graft-versus-host disease (aGVHD) after bone marrow transplantation (BMT) and peripheral blood stem cell transplantation (PBSCT) from human leukocyte antigen (HLA)-mismatched, unrelated (n = 9) and related donors (n = 4) in an open single-centre phase II study.	10770416
Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	The patient underwent eight cycles of CHOP regimen and high-dose chemotherapy (HDC) with peripheral blood stem cell transplantation (PBSCT).	10770567
Neoplasms	Stem Cell Exhaustion	[Single and double high-dose chemotherapy with autologous stem cell transplantation in children with advanced solid tumors: first experiences].	10780056
Treatment related secondary malignancy	Stem Cell Exhaustion	The interest in HDT intensified when autologous stem cells mobilised from the peripheral blood became available, in view of the possibility of increasing the cell dose, which correlates directly with the time period of haematopoietic recovery and thus reduces therapy-associated toxicity.	10780056
Gastrointestinal Stromal Tumors, Plexosarcoma	Stem Cell Exhaustion	Recent studies indicate that a subgroup of gastrointestinal stromal tumors, including gastrointestinal autonomic nerve tumors (GANTs), originate from stem cells that differentiate toward a pacemaker-cell phenotype.	10782882
Lymphoma	Stem Cell Exhaustion	Management of patients with heavily pretreated malignant lymphoma failing frontline treatment and salvage high-dose chemotherapy and autologous peripheral stem cell rescue, is problematic.	10791194
Mastocytosis, Hypersensitivity	Stem Cell Exhaustion	Mastocytosis cells bearing a c-kit activating point mutation are characterized by hypersensitivity to stem cell factor and increased apoptosis.	10792276
Stem Cell Factor	Stem Cell Exhaustion	The role of the c-Kit receptor and its ligand stem cell factor (SCF) in the pathogenesis of the disease was analysed in marrow cell clonogenic assays.	10792276
PAFAH1B1 wt Allele, Stem Cell Factor, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We assessed PEG-rHuMGDF combined with granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF (GM-CSF), interleukin 3 (IL-3), IL6, stem cell factor (SCF) or erythropoietin in 40 MDS, 33 AML and 16 normal bone marrow samples.	10792278
Multiple Myeloma	Stem Cell Exhaustion	Seventeen newly diagnosed patients with myeloma (median age 55 years; 30-65) were initially treated with courses of infused cyclophosphamide, vincristine, adriamycin and methylprednisolone (C-VAMP) followed by melphalan 200 mg/m2(HDM) and peripheral blood stem cell rescue (PBSC).	10800062
Radiation-Related Angiosarcoma, Neoplasms, leukemia	Stem Cell Exhaustion	At the time of diagnosis of radiation-induced sarcoma, the patient was free of leukemia and had several risk factors already reported to favor the development of solid tumors in stem cell recipients.	10800073
Concomitant Medication Submission Domain, Multiple Myeloma	Stem Cell Exhaustion	Dose-intensive melphalan with stem cell support (CM regimen) is effective and well tolerated in elderly myeloma patients.	10800168
Concomitant Medication Submission Domain	Stem Cell Exhaustion	Between December 1994 and May 1997, 12 Italian Multiple Myeloma Study Group institutions entered 68 patients at diagnosis (median age 65) into an intensified chemotherapy regimen: cyclophosphamide (CY) 3 g/m(2) plus melphalan 60 mg/m(2) followed by peripheral blood progenitor cells (PBPC) and G-CSF (CM regimen).	10800168
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	He received standard AML induction and consolidation therapy, after which he underwent allogeneic transplantation using HLA-matched sibling stem cells obtained from the umbilical cord.	10803527
Childhood Breast Carcinoma, Cardiotoxicity, Lymphoma	Stem Cell Exhaustion	We sought to define risk factors predisposing breast cancer and lymphoma patients to cardiac and pulmonary toxicity when undergoing high-dose chemotherapy (HDC) and autologous stem cell rescue (ASCR).	10808211
Small cell carcinoma of lung	Stem Cell Exhaustion	In this study, we determined whether mRNA of bombesin receptors is detectable in PB or peripheral blood progenitor cell (PBPC) samples from patients with small cell lung cancer.	10810412
Toxic effect	Stem Cell Exhaustion	Expected toxicities were hematopoietic, requiring stem cell re-infusion in 5 patients.	10811451
Primary malignant neoplasm	Stem Cell Exhaustion	Evaluation of the predictive value of Her-2/neu overexpression and p53 mutations in high-risk primary breast cancer patients treated with high-dose chemotherapy and autologous stem-cell transplantation.	10811672
Lymphoma, Non-Hodgkin, Immune System Diseases	Stem Cell Exhaustion	Immune dysfunction despite high levels of immunoregulatory cytokine gene expression in autologous peripheral blood stem cell transplanted non-Hodgkin's lymphoma patients.	10812239
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	We analyzed the steady-state mRNA cytokine levels and the immune phenotype and function in the peripheral blood mononuclear cells from intermediate-grade non-Hodgkin's lymphoma patients prior to and following high-dose chemotherapy and peripheral stem cell transplantation.	10812239
Hematologic Neoplasms	Stem Cell Exhaustion	[Autologous transplantation of peripheral blood hematopoietic stem cells in the treatment of hematological malignancies.	10812643
Hematologic Neoplasms	Stem Cell Exhaustion	61 autologous transplantations for haematological malignancies have been performed with peripheral blood stem cells in 60 patients.	10812643
Hematologic Neoplasms, Toxic effect	Stem Cell Exhaustion	In conclusion, transplantation with peripheral blood stem cells is well tolerated, has a low toxicity rate, and can be used safely for patients with haematological malignancies.	10812643
Recurrent T-Cell Non-Hodgkin Lymphoma	Stem Cell Exhaustion	TCR-Vbeta repertoire analysis with RT-PCR was useful for the early detection of pulmonary relapsed T-cell lymphoma after autologous peripheral blood stem cell transplantation.	10814993
Lymphoma	Stem Cell Exhaustion	Pulmonary recurrence of malignant lymphoma is a rare event after stem cell transplantation.	10814993
Cardiotoxicity, Childhood Breast Carcinoma	Stem Cell Exhaustion	We retrospectively evaluated 443 breast cancer patients treated with high-dose cyclophosphamide, cisplatin, and BCNU (STAMP-I) with autologous stem cell support to characterize the cardiac toxicity of this regimen.	10816028
Myeloid-Lymphoid Leukemia Protein	Stem Cell Exhaustion	Differential expression of lymphoid and myeloid markers on differentiating hematopoietic stem cells in normal and tumor-bearing adult human liver.	10827150
Intrahepatic Route of Drug Administration, Neoplasms	Stem Cell Exhaustion	While tumor-bearing livers are enriched for intrahepatic myeloid precursors and T-cell progenitor cells, further studies are required to establish the origin and in situ development potential of hepatic HSCs in the adult human and their role in tumor immunity.	10827150
Lymphoma	Stem Cell Exhaustion	Allogeneic peripheral blood stem cell transplantation using a fludarabine-based low intensity conditioning regimen for malignant lymphoma.	10828860
Sequela of disorder, Childhood Breast Carcinoma	Stem Cell Exhaustion	Cardiac sequelae of doxorubicin and paclitaxel as induction chemotherapy prior to high-dose chemotherapy and peripheral blood progenitor cell transplantation in women with high-risk primary or metastatic breast cancer.	10828864
immunoglobulin A	Stem Cell Exhaustion	Melphalan therapy followed by reinfusion of haemopoietic blood stem cells collected from the patient led to the improvement of the clinical status, although mixed chimerism and an elevated serum IgA persisted.	10828874
Carcinoma, Transitional Cell	Stem Cell Exhaustion	Recent molecular genetic studies have suggested that multifocal urothelial carcinomas are monoclonally derived from an identical transformed progenitor cell.	10830781
Glaucoma, CTCAE	Stem Cell Exhaustion	Amniotic membrane transplantation or conjunctival limbal autograft for limbal stem cell deficiency induced by 5-fluorouracil in glaucoma surgeries.	10832684
Toxic effect, Glaucoma, CTCAE	Stem Cell Exhaustion	To determine if human amniotic membrane transplantation or limbal stem cell transplantation is effective to restore the corneal surface with partial or total limbal stem cell deficiency, respectively, caused by 5-fluorouracil (5-FU) toxicity after glaucoma surgeries.	10832684
Low Vision	Stem Cell Exhaustion	Partial and total limbal stem cell deficiency was confirmed by impression cytology as the cause of reduced vision and corneal surface breakdown in a 69-year-old man and a 67-year-old man, respectively, who both had received a total of 105 mg 5-FU injections.	10832684
Avascular Necrosis, CTCAE	Stem Cell Exhaustion	For a period of 15 months of follow-up, the visual acuity improved, and their corneal surfaces remained avascular, smooth, and without recurrence of limbal stem cell deficiency.	10832684
Glaucoma, CTCAE	Stem Cell Exhaustion	Limbal stem cell deficiency can occur as a late complication for patients receiving 5-FU after glaucoma filtering surgeries.	10832684
Congestive heart failure, Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	Congestive heart failure after peripheral blood stem cell transplantation: role of cytokines.	10834455
Congestive heart failure, Peripheral Stem Cell Transplantation, Lymphoma, organic heart disease	Stem Cell Exhaustion	A 32-year-old woman was admitted with the diagnosis of congestive heart failure (CHF) without organic heart disease after peripheral blood stem cell transplantation (PBSCT) for malignant lymphoma.	10834455
Doctor of Chiropractic, Dilated Cardiomyopathy Pathway, Congestive heart failure	Stem Cell Exhaustion	Various cytokines have been reported to be released from stem cells after PBSCT and some have a suppressive effect on myocardial contractility; elevated levels of cytokines have been reported in dilated cardiomyopathy (DCM) and/or CHF patients.	10834455
Hematological Disease, Neoplasms	Stem Cell Exhaustion	[Eight years of experience in a single institution in hematopoietic stem cell autologous transplantation in malignant hematological diseases and in solid tumors].	10835708
Childhood Breast Carcinoma	Stem Cell Exhaustion	Dose-intensive chemotherapy regimens without stem cell support have not resulted in an improved survival compared to standard dose regimens in patients with metastatic breast cancer.	10845809
leukemia, Acute leukemia, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Treatment-related mortality rates were lower and leukemia-free survival rates were higher with blood stem cell transplants in patients with advanced leukemia (acute leukemia in second remission or chronic myelogenous leukemia in accelerated phase) but not in early leukemia (acute leukemia in first remission or chronic myelogenous leukemia in chronic phase).	10845900
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Because early normal hematopoietic stem cells do not express Bcl-2, Bcl-2-AS therapy should be highly selective for AML cells.	10845930
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Bcl-2-AS also inhibited colony formation of AML progenitor cells.	10845930
Hematologic Neoplasms, Hypogonadism, Erectile dysfunction	Stem Cell Exhaustion	We studied 24 male patients aged 26-62 years (median 41) prospectively presenting over a 5 year period with clinical features of hypogonadism and erectile dysfunction (ED), who had been treated with autologous or allogeneic bone marrow/stem cell transplant for a variety of haematological malignancies and had received either high-dose chemotherapy or high-dose chemotherapy combined with total body irradiation (TBI).	10849531
Colorectal	Stem Cell Exhaustion	In this paper, a hypothesis is presented in which tumoral development in human colon and rectum would be the consequence of having exceeded the 'limit number' of mitoses that every stem cell undertakes, from its origin until exhausting the security mechanisms that control the correct replication of genome.	10859673
Febrile Neutropenia	Stem Cell Exhaustion	Routine chest radiography for the evaluation of febrile neutropenic patients after autologous stem cell transplantation.	10861811
Ceramide Nanoliposome	Stem Cell Exhaustion	We report the case of a 76-year-old woman with CNL with partial deletion of the long arm of chromosome 20 in a subset of bone marrow metaphases, suggesting coexistence of a clonal stem cell disorder and normal hematopoiesis.	10861824
Bare Lymphocyte Syndrome, Hemolysis (lab result)	Stem Cell Exhaustion	After allogeneic peripheral blood progenitor cell (PBPC) transplantation, a patient developed a severe hemolytic transfusion reaction due to passenger lymphocyte syndrome.	10864980
Acute Promyelocytic Leukemia	Stem Cell Exhaustion	Treatment of relapsing acute promyelocytic leukemia by all-trans retinoic acid therapy followed by timed sequential chemotherapy and stem cell transplantation.	10865965
ATRICHIA WITH PAPULAR LESIONS	Stem Cell Exhaustion	The purpose of this study was to assess the safety and efficacy of stem cell transplantation (SCT) mainly autologous SCT as consolidation therapy in APL patients who relapsed and achieved a second complete remission (CR2).	10865965
Toxic effect	Stem Cell Exhaustion	Reasons for not autografting were early relapse (three patients), severe toxicity of EMA chemotherapy (six patients), and refusal or failure of stem cell harvest (three patients).	10865965
Lymphoid	Stem Cell Exhaustion	Thus, we could identify an uncommitted stem cell origin among Ph-positive ALLs only in those patients whose disease subsequently proved to be a lymphoid blastic crisis with clinically silent chronic phase.	10865978
Graft-vs-Host Disease, Neoplasms	Stem Cell Exhaustion	To review the outcome of HLA-compatible sibling allogeneic peripheral blood progenitor cell (PBPC) transplants using fludarabine-based conditioning in patients ineligible for a conventional transplant, with emphasis on engraftment, graft vs host disease (GVHD) and graft vs tumour effects.	10868492
Aneuploidy	Stem Cell Exhaustion	Growing cells also exhibited three morphologic characteristics: those possessing stem cell-like morphology and characteristics such as small size, high density, developed cytokeratin systems, PSMA expression, and aneuploidy; those in M phase; and cell clusters.	10870062
Childhood Breast Carcinoma	Stem Cell Exhaustion	Transplantation of highly purified CD34+Thy-1+ hematopoietic stem cells in patients with metastatic breast cancer.	10871151
Childhood Breast Carcinoma	Stem Cell Exhaustion	We report here the transplantation of extensively purified "mobilized" peripheral blood CD34Thy-1 hematopoietic stem cells from 22 patients with recurrent or metastatic breast cancer.	10871151
Respiratory Depression, Amyloidosis	Stem Cell Exhaustion	Severe respiratory depression after dimethylsulphoxide-containing autologous stem cell infusion in a patient with AL amyloidosis.	10871736
Respiratory arrest, Amyloidosis	Stem Cell Exhaustion	We report here a 58-year-old female with AL amyloidosis who developed an unexpected episode of respiratory arrest a few seconds after the beginning of thawed stem cell product infusion.	10871736
Juvenile-Onset Still Disease	Stem Cell Exhaustion	Prolonged remission state of refractory adult onset Still's disease following CD34-selected autologous peripheral blood stem cell transplantation.	10871738
T-Cell Lymphoma	Stem Cell Exhaustion	Effective high-dose chemotherapy combined with CD34+-selected autologous peripheral blood stem cell transplantation in a patient with cutaneous CD30-negative large T cell lymphoma.	10871740
T-Cell Lymphoma	Stem Cell Exhaustion	As CD30-negative cutaneous large T cell lymphoma has a poor prognosis despite intensive chemotherapy, high-dose chemotherapy followed by CD34+-selected autologous peripheral blood stem cell transplantation (CD34+-APBSCT) was prescribed.	10871740
Graft-vs-Host Disease, Necrosis	Stem Cell Exhaustion	We encountered a similar case of columnar epidermal necrosis in a 15-year-old Japanese girl with chronic graft-vs-host disease; the lesions occurred 3 months after the transfusion of peripheral blood stem cells from her HLA antigen-matched brother.	10871937
Toxic effect	Stem Cell Exhaustion	Nonmyeloablative conditioning regimens based on the use of purine analogs can induce sufficient immunosuppression to allow engraftment after allogeneic stem cell transplantation, resulting in less toxicity than standard conditioning regimens.	10877059
Renal carnitine transport defect	Stem Cell Exhaustion	We describe a clinical trial using a nonmyeloablative chemotherapy conditioning regimen followed by related allogeneic peripheral blood stem cell transplantation that represents a novel approach to the treatment of severe SCD in young adults.	10877059
MYELODYSPLASTIC SYNDROME, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome is a preleukemic, clonal disorder of the hematopoetic stem cell.	10879305
Malignant neoplasm of breast	Stem Cell Exhaustion	Although there seems to be a common stem cell for the two epithelial cell types in the breast, the vast majority of breast cancers exhibit a luminal phenotype.	10879734
Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	The differential bcl-2 expression in the various clinicopathological subtypes of BCCs suggests that, despite the common derivation of these tumours from a primitive basaloid stem cell and a limited potential for metastasis, they form a heterogeneous group of tumours that differ markedly in histologic and biological behaviour.	10885404
Hereditary sideroblastic anemia	Stem Cell Exhaustion	Allogeneic peripheral stem cell transplantation in a case of hereditary sideroblastic anaemia.	10886220
Hereditary sideroblastic anemia	Stem Cell Exhaustion	We report on a case of pyridoxine refractory hereditary sideroblastic anaemia (HSA) in a 19-year-old man who underwent peripheral blood stem cell transplantation (PBSCT) from his HLA-identical brother.	10886220
Eruptions	Stem Cell Exhaustion	A healthy 12-month-old donor treated with G-CSF for collection of stem cells from peripheral blood developed a discrete, papular, erythematous eruption which histologically showed irregularly shaped lymphocytes with mitoses.	10886753
Thrombocytosis, Polycythemia Vera, Primary Myelofibrosis, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Neoplastic diseases of the multipotent haematopoietic stem cells result in four major diseases: chronic myelogenous leukaemia (CML); polycythaemia vera (PV); agnogenic myeloid metaplasia with myelofibrosis (AMM/MF); essential thrombocytosis (ET).	10895623
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	Recurrence NHL was treated in accordance with the guidelines with second-line chemotherapy, if possible followed by peripheral stem cell transplantation in a haematooncological centre.	10897302
Neoplasms	Stem Cell Exhaustion	Based on our results, we favor the hypothesis of monoclonal origin of this salivary gland carcinosarcoma with a common stem cell that could be the myoepithelial cell and an inactivated tumor suppressor gene on chromosome 17 other than p53.	10899675
Childhood Breast Carcinoma, Mobilized Peripheral Blood Stem Cell	Stem Cell Exhaustion	Forty-one women with chemotherapy-responsive advanced breast cancer received cyclophosphamide (4 g/m2) for peripheral blood stem cell mobilization (treatment 1) followed by high-dose cyclophosphamide (1.5 g/m2 per day for 4 days), thiotepa (200 mg/m2 per day for 4 days), and novobiocin (4 g/day orally for 7 days) (treatment 2) and autologous marrow support.	10905771
Multiple Myeloma	Stem Cell Exhaustion	Transplantation with selected autologous peripheral blood CD34+Thy1+ hematopoietic stem cells (HSCs) in multiple myeloma: impact of HSC dose on engraftment, safety, and immune reconstitution.	10907648
Sequela of disorder, Multiple Myeloma, Neoplasms, Complement System Proteins	Stem Cell Exhaustion	The aims of our study performed in myeloma were to evaluate the performance and the safety of Systemix's high-speed clinical cell sorter, to assess the safety and efficacy of deescalating cell dose cohorts of CD34+Thyl+ hematopoietic stem cells (HSCs) as autologous grafts by determining engraftment, and to assess the residual tumor cell contamination using polymerase chain reaction (PCR) amplification assays of patient-specific complementarity determining region III (CDR III) analysis for residual myeloma cells.	10907648
Cytomegalovirus Infections, Toxic effect	Stem Cell Exhaustion	A phase I-II trial to examine the toxicity of CMV- and EBV-specific cytotoxic T lymphocytes when used for prophylaxis against EBV and CMV disease in recipients of CD34-selected/T cell-depleted stem cell transplants.	10910142
Toxic effect	Stem Cell Exhaustion	This protocol is a Phase I/II study to examine the toxicity associated with and the immunologic effects of ex vivo simultaneously expanded EBV- and CMV-specific CTL for prophylaxis against EBV and CMV complications in recipients of CD34 selected/T-cell depleted stem cell transplants (SCT).	10910142
Peripheral Stem Cell Transplantation, Malignant neoplasm of testis	Stem Cell Exhaustion	High-dose chemotherapy with peripheral blood stem cell transplantation for advanced testicular cancer.	10910228
Malignant neoplasm of testis	Stem Cell Exhaustion	High-dose chemotherapy followed by peripheral blood stem cell transplantation is safe and effective for use in patients with far-advanced testicular cancer, particularly when the high-dose chemotherapy is conducted as the initial treatment.	10910228
Multiple Myeloma	Stem Cell Exhaustion	Delayed stem cell transplantation for the management of relapsed or refractory multiple myeloma.	10918404
Multiple Myeloma	Stem Cell Exhaustion	The optimal timing of stem cell transplantation for multiple myeloma is controversial.	10918404
Bacteremia, Peripheral Stem Cell Transplantation, Arthritis, Infectious	Stem Cell Exhaustion	Agrobacterium yellow group: bacteremia and possible septic arthritis following peripheral blood stem cell transplantation.	10918412
Oligoarticular Arthritis, Hodgkin Disease, Sepsis	Stem Cell Exhaustion	A 47-year-old male patient developed sepsis and monoarticular arthritis following autologous stem cell transplantation for recurrent Hodgkin's disease.	10918412
Graft-vs-Host Disease	Stem Cell Exhaustion	Tacrolimus is increasingly used for graft-versus-host disease (GVHD) prophylaxis and therapy in the allogeneic stem cell transplant (allo-SCT) setting.	10918414
Neoplasms, Lymphoma, leukemia	Stem Cell Exhaustion	Between February 1998 and October 1999, 24 patients with advanced leukemia, lymphoma or solid tumors received G-CSF mobilized peripheral blood stem cells (PBSC) from HLA-matched sibling donors after dose-reduced conditioning therapy.	10918420
Lymphoproliferative Disorders	Stem Cell Exhaustion	Mobilization kinetics of peripheral blood progenitor cells after IAPVP-16 salvage chemotherapy plus G-CSF in lymphoproliferative disorders.	10918421
Wiskott-Aldrich Syndrome	Stem Cell Exhaustion	Unrelated partially matched peripheral blood stem cell transplantation with highly purified CD34+ cells in a child with Wiskott-Aldrich syndrome.	10918439
Wiskott-Aldrich Syndrome	Stem Cell Exhaustion	Stem cell transplantation is the only curative approach to the treatment of Wiskott-Aldrich syndrome.	10918439
Wiskott-Aldrich Syndrome	Stem Cell Exhaustion	In an attempt to prevent these problems, a 6-year-old boy with Wiskott-Aldrich syndrome lacking a suitable family donor, was transplanted with large numbers of unrelated highly purified CD34+ peripheral blood stem cells mismatched at one C locus.	10918439
Decreased platelet count	Stem Cell Exhaustion	To explore the influence of dose and schedule on the ability of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) to abrogate thrombocytopenia after multiple cycles of chemotherapy and to mobilize peripheral-blood progenitor cells (PBPC).	10920133
Polycythemia Vera, Iron-Refractory Iron Deficiency Anemia	Stem Cell Exhaustion	We describe the unusual presentation of a patient with microcytic anemia in whom the diagnosis of polycythemia vera was reached using the PVSG criteria and confirmed by in vitro culture assay of erythroid progenitor cells.	10923962
Ocular surface disease	Stem Cell Exhaustion	Fourteen patients with ocular surface disease unresponsive to standard medical and surgical treatments, including seven patients with presumed limbal stem cell deficiency were chosen for transplantation of a bioengineered composite corneal surface in eye each.	10928750
Ocular surface disease	Stem Cell Exhaustion	The resultant composite cultured tissue can be transplanted and appears to successfully manage eyes with difficult ocular surface disease, including those with stem cell deficiency.	10928750
Ocular surface disease	Stem Cell Exhaustion	To bioengineer a corneal surface replacement using ex vivo expanded, cultured corneal epithelial stem cells seeded on a matrix derived from amniotic membrane and use this bioengineered graft to manage difficult ocular surface disease.	10928750
Malignant Neoplasms	Stem Cell Exhaustion	Furthermore, it is argued that this low figure implies that mutations occurring during early life, including organogenesis, are relatively important in initiating stem cell-derived malignancy.	10930979
Granulocyte-Macrophage Progenitor Cells	Stem Cell Exhaustion	The patient had an increased amount of bone marrow granulocyte-macrophage progenitor cells, which formed colonies in response to a very low dose (0.1 ng/mL) of granulocyte-colony stimulating factor.	10931454
Acute GVH disease	Stem Cell Exhaustion	A case of acute graft-versus-host disease following autologous peripheral blood stem cell transplantation.	10935341
Erythema, Lymphoma, Non-Hodgkin, Dermatitis	Stem Cell Exhaustion	A 42-year-old woman developed severe erythema with exfoliative scaling on the bilateral palms and soles and erosive dermatitis on the axillae and groin eight days after an autologous peripheral blood stem cell transplantation for the treatment of non-Hodgkin's lymphoma.	10935341
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Serum ICAM-1 concentrations following conventional dose consolidation chemotherapy for acute myeloid leukemia and after high dose chemotherapy with autologous haematopoietic stem cell rescue.	10938403
Childhood Breast Carcinoma, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Serum concentrations of soluble ICAM-1 (sICAM-1) were studied in patients with acute myeloid leukemia (AML) after conventional dose consolidation chemotherapy and in AML and in breast cancer patients following high dose chemotherapy with autologous haematopoietic stem cell transplantation.	10938403
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Expression of CD11b/CD18 on neutrophils after consolidation chemotherapy for acute myeloid leukemia and after high dose chemotherapy with autologous haematopoietic stem cell transplantation.	10938404
Mastocytosis	Stem Cell Exhaustion	Soluble stem cell factor receptor (CD117) and IL-2 receptor alpha chain (CD25) levels in the plasma of patients with mastocytosis: relationships to disease severity and bone marrow pathology.	10942367
Lymphoma, Non-Hodgkin, Familial, Recurrent Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Relapsed non-Hodgkin's lymphoma (NHL) is preferably treated with high-dose therapy and stem cell support.	10942927
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	It should be considered for patients with relapsed or refractory NHL who are not candidates for standard reinduction therapy and stem cell transplantation.	10942927
Aggressive Non-Hodgkin Lymphoma, Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	High-dose chemotherapy with autologous hematopoietic stem cell transplantation has been expected to result in a promising outcome in high risk aggressive non-Hodgkin's lymphoma (NHL).	10953973
Aggressive course	Stem Cell Exhaustion	The mobilization kinetics of circulating progenitor cells in patients with aggressive NHL is dependent on the dosage and schedule of CHOP.	10953973
Toxic effect	Stem Cell Exhaustion	Although these data demonstrate the feasibility of delivering parenteral amifostine in conjunction with dose-intensive chemotherapy and autologous peripheral blood stem cell transplantation, there was no evidence of a significant reduction in nonmarrow toxicities.	10955873
Adenoma, Adenoid Cystic Carcinoma	Stem Cell Exhaustion	These results strongly suggest (1) that the luminal cell progenitors transform into major constituents of pleomorphic adenoma cells with keratin 14 but not smooth muscle proteins, and (2) that the peripheral cells of adenoid cystic carcinoma are derived from undifferentiated MECs.	10963381
Tumor necrosis, Stem Cell Factor, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Peripheral blood mononuclear cells (PBMCs) from 15 newly diagnosed acute myeloid leukemia (AML) patients were cultured in fetal calf serum-free media supplemented with either granulocyte/macrophage-colony stimulating factor (GM-CSF), interleukin (IL)-4 and tumor necrosis factor alpha (TNFalpha), or GM-CSF, stem cell factor (SCF), TNFalpha and transforming growth factor beta (TGFbeta) in order to generate leukemia-derived dendritic cells (DCs).	10965783
Primary malignant neoplasm	Stem Cell Exhaustion	Recently high-dose chemotherapy (HDC) with autologous stem cell support has been introduced as adjuvant treatment for high-risk primary breast cancer and for selected subsets of women with metastatic disease.	10966000
Childhood Breast Carcinoma	Stem Cell Exhaustion	One hundred and ninety-one breast cancer patients (99 stage II/IIIA; 27 stage IIIB; 65 stage IV responsive to conventional-dose chemotherapy) were treated with high-dose chemotherapy (CTM) delivered over 4 days (cyclophosphamide (6 g/m2), thiotepa (600 mg/m2), and mitoxantrone (24-60 mg/m2)) followed by autologous hematopoietic stem cell rescue.	10967563
leukemia, Malignant Neoplasms	Stem Cell Exhaustion	Myelodysplasias and leukemias after autologous stem cell transplantation for lymphoid malignancies.	10967573
Communicable Diseases	Stem Cell Exhaustion	A total of 1,305 blood samples from 85 solid organ transplant (SOT) recipients and 25 stem cell transplant (SCT) recipients at risk for cytomegalovirus (CMV) infection were prospectively collected and tested using the shell vial assay (SVA) and a leukocytic qualitative PCR (q-PCR).	10970347
Secondary malignant neoplasm of lung, Adrenocortical carcinoma	Stem Cell Exhaustion	In a 29-year-old patient with adrenocortical carcinoma with metastases to the lung and bone, an adjuvant bone marrow graft using peripheral stem cells was unsuccessful.	10970942
Neoplasms	Stem Cell Exhaustion	Regimens appropriate to the tumour type were administered and haemopoietic reconstitution was achieved with peripheral blood progenitor cells (PBPC; n = 275), autologous bone marrow (auto-BMT; n = 69) or allogeneic bone marrow (allo-BMT; n = 85).	10971384
Myeloproliferative disease, Fibrosis Assessment, Primary Myelofibrosis	Stem Cell Exhaustion	Myelofibrosis with myeloid metaplasia (MMM) is an uncommon chronic myeloproliferative disorder characterized by clonal stem cell proliferation and reactive non-clonal proliferation of bone marrow fibroblasts with fibrosis.	10971393
Venoocclusive disease	Stem Cell Exhaustion	Is veno-occlusive disease a specific syndrome or the exacerbation of physiopathologic hemostatic changes in hematopoietic stem cell transplantation (HSCT)?	10973671
Venoocclusive disease	Stem Cell Exhaustion	The objective of the present study was to analyze whether veno-occlusive disease (VOD) is based on specific findings or whether this syndrome is the exacerbation of changes in hemostatic parameters that develop following hematopoietic stem cell transplantation (HSCT).	10973671
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Untreated aggressive mantle cell lymphoma: results with intensive chemotherapy without stem cell transplant in elderly patients.	10975386
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Aggressive mantle cell lymphoma has a poor prognosis with current therapy and occurs frequently in an elderly population which cannot receive stem cell transplantation.	10975386
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Intermittent courses of melphalan and prednisone is still the standard chemotherapy for the initial treatment of multiple myeloma (MM) in patients who cannot undergo high-dose chemotherapy/radiotherapy with either allogeneic or autologous stem cell transplantation.	10975391
Multiple Myeloma	Stem Cell Exhaustion	Treatment of primary resistant or relapsed multiple myeloma with high-dose chemoradiotherapy, hematopoietic stem cell rescue, and granulocyte-macrophage colony-stimulating factor.	10975514
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	In this prospective, multicenter, phase 2 study, multiple myeloma (MM) patients with primary resistant disease or recurrent chemosensitive disease, in chemoresistant relapse, or in second or subsequent remission were treated with high-dose chemoradiotherapy followed by autologous peripheral blood stem cell (PBSC) rescue.	10975514
Toxic effect	Stem Cell Exhaustion	Patients underwent high-dose chemoradiotherapy consisting of melphalan (140 mg/m2 x 1 day), cyclophosphamide (60 mg/kg per day x 2 days), methylprednisolone (2 g/d x 7 days), and total body radiation (150 cGy bid x 3 days) followed by peripheral blood stem cell reinfusion (> or = 1.2 x 10(9) mononucleated cells per kg) and GM-CSF support (5 microg/kg per day) and were evaluated for response, survival, and toxicity.	10975514
Aplastic Anemia	Stem Cell Exhaustion	Recovery of hematopoietic progenitor cells in patients with severe aplastic anemia who obtained good clinical response with a combination therapy of immunosuppressive agents and recombinant human granulocyte colony-stimulating factor.	10979207
Cellulitis	Stem Cell Exhaustion	Refractory facial cellulitis following cosmetic rhinoplasty after cord-blood stem cell transplantation.	10979217
Cellulitis	Stem Cell Exhaustion	We report a case of a 38-year-old female patient who developed facial cellulitis after cord-blood stem cell transplantation (CBT).	10979217
Tumor necrosis	Stem Cell Exhaustion	CD40 is a member of the tumor necrosis factor receptor super-family expressed by B cells, monocytes, dendritic cells, epithelial cells and hematopoietic progenitor cells.	10980464
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	A retrospective analysis of 144 patients with aggressive non-Hodgkin's lymphoma: impact of autologous stem cell transplantation in first remission on outcome.	10980633
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	To analyze the impact of a sequential program including autologous stem cell transplantation in first remission on the outcome of patients with aggressive non-Hodgkin's lymphoma.	10980633
Chronic Lymphocytic Leukemia, Multiple Myeloma	Stem Cell Exhaustion	Occurrence of multiple myeloma after fludarabine treatment of a chronic lymphocytic leukemia: evidence of a biclonal derivation and clinical response to autologous stem cell transplantation.	10980639
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	We describe a 49-year old patient who developed a III stage IgD k MM after fludarabine treatment for a previous diagnosis of CLL and then was submitted to an high-dose treatment with autologous CD34+ selected stem cell support.	10980639
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Our results suggest that in this patient CLL and MM originate from separate B-cell progenitors.	10980639
Neoplasms	Stem Cell Exhaustion	Several devices for selection of CD34+ peripheral blood stem cells (PBSC) have been used during the last years for reducing tumor cell contamination of the graft.	10982256
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation.	10984562
Hematologic Neoplasms, Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Since allogeneic stem-cell transplantation can induce curative graft-versus-leukemia reactions in patients with hematologic cancers, we sought to induce analogous graft-versus-tumor effects in patients with metastatic renal-cell carcinoma by means of nonmyeloablative allogeneic peripheral-blood stem-cell transplantation.	10984562
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Nineteen consecutive patients with refractory metastatic renal-cell carcinoma who had suitable donors received a preparative regimen of cyclophosphamide and fludarabine, followed by an infusion of a peripheral-blood stem-cell allograft from an HLA-identical sibling or a sibling with a mismatch of a single HLA antigen.	10984562
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Nonmyeloablative allogeneic stem-cell transplantation can induce sustained regression of metastatic renal-cell carcinoma in patients who have had no response to conventional immunotherapy.	10984562
Osteoporotic Fractures	Stem Cell Exhaustion	Mesenchymal stem cells from osteoporotic patients produce a type I collagen-deficient extracellular matrix favoring adipogenic differentiation.	10996846
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Haematopoietic stem cell transplantation for patients with myelo-dysplastic syndromes and secondary acute myeloid leukaemias: a report on behalf of the Chronic Leukaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT).	10997974
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic stem cell transplantation from an HLA-identical sibling donor is a curative treatment option for a young patient with myelodysplastic syndrome, limited by age and lack of sibling donors.	10997974
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Both allogeneic and autologous stem cell transplantation have emerged as treatment options for patients with myelodysplastic syndromes.	10997974
Gigantism	Stem Cell Exhaustion	Long-acting peptidomimergic control of gigantism caused by pituitary acidophilic stem cell adenoma.	10999842
Acidophil Stem Cell Pituitary Gland Adenoma	Stem Cell Exhaustion	Histology, immunostaining, and electron microscopy demonstrated a pituitary acidophil stem cell adenoma.	10999842
Gigantism, Acidophil Stem Cell Pituitary Gland Adenoma	Stem Cell Exhaustion	In conclusion, administration of long-acting somatostatin analog every 4 weeks in combination with a long-acting dopamine agonist biweekly controlled biochemical parameters and accelerated growth in a patient with gigantism caused by a rare pituitary acidophil stem cell adenoma.	10999842
Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	High-dose chemoradiotherapy and autologous stem cell transplantation for patients with primary refractory aggressive non-Hodgkin lymphoma: an intention-to-treat analysis.	11001890
Lymphoma, Non-Hodgkin, Familial, Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	High-dose chemoradiotherapy (HDT) with autologous stem cell transplantation (ASCT) is the treatment of choice for patients with relapsed aggressive non-Hodgkin lymphoma (NHL).	11001890
Primary amyloidosis	Stem Cell Exhaustion	[High-dose melphalan treatment followed by hematopoietic progenitor cell rescue in primary amyloidosis].	11002461
Myelosuppression, Peripheral Stem Cell Transplantation, Childhood Breast Carcinoma, Malignant Female Reproductive System Neoplasm	Stem Cell Exhaustion	For the purposes of illustration, preliminary safety and activity data from one ongoing phase 1 myelosuppression trial (rHuTPO in women with advanced gynecologic malignancies receiving carboplatin) and one ongoing phase 1 myeloablation trial (rHuTPO for peripheral blood progenitor cell mobilization prior to myeloablative chemotherapy for high risk breast cancer) will be presented.	11012192
Decreased platelet count	Stem Cell Exhaustion	The problem of thrombocytopenia after hematopoietic stem cell transplantation.	11012230
Hemorrhage, Decreased platelet count	Stem Cell Exhaustion	Thrombocytopenia after hematopoietic stem cell transplantation (HSCT) is associated with an increased risk of bleeding and utilization of significant resources.	11012230
Leukemia, Myelocytic, Acute, Communicable Diseases	Stem Cell Exhaustion	Risk factors associated with delayed platelet engraftment after autologous HSCT included use of marrow rather than peripheral blood as the source of stem cells, being transplanted for acute myeloid leukemia rather than other diseases, positive patient serology for cytomegalovirus and the presence of infection post-transplant before engraftment.	11012230
Hodgkin Disease, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	A randomized phase 2 study of PBPC mobilization by stem cell factor and filgrastim in heavily pretreated patients with Hodgkin's disease or non-Hodgkin's lymphoma.	11019835
Hodgkin Disease, Lymphoma, Non-Hodgkin, Stem Cell Factor, Lymphoma, Non-Hodgkin, Familial, HD Term Type	Stem Cell Exhaustion	This randomized, controlled study compared the ability to mobilize and collect an optimal target yield of 5 x 10(6) CD34+ cells/kg using stem cell factor (SCF; 20 microg/kg/day) plus filgrastim (G-CSF; 10 microg/kg/day) vs filgrastim alone (10 microg/kg/day) in 102 patients diagnosed with non-Hodgkin's lymphoma (NHL) or Hodgkin's disease (HD), who were prospectively defined as being heavily pretreated.	11019835
Multiple Myeloma, Lymphoma, Non-Hodgkin, Stem Cell Factor, Lymphoma, Non-Hodgkin, Familial, Morular Metaplasia of the Endometrium	Stem Cell Exhaustion	Three early acting (stem cell factor (SCF), Flt3 ligand (Flt3) and fetal antigen 1 (FA1)) and three lineage-specific growth factors (EPO, G-CSF and thrombopoietin (Tpo)) were analyzed by ELISA in 16 patients with multiple myeloma (MM) and 16 patients with non-Hodgkin's lymphoma (NHL).	11019842
Lymphoma, Non-Hodgkin, Familial, Stem Cell Factor	Stem Cell Exhaustion	The relative number of SCF, Flt3, Tpo and G-CSF receptor positive, CD34+ progenitor cells were measured by flow cytometry in the leukapheresis product used for transplantation in a subgroup of 15 patients (NHL, n = 8, MM, n = 7).	11019842
Communicable Diseases	Stem Cell Exhaustion	Infection remains an important cause of morbidity and mortality after bone marrow or stem cell transplantation.	11019843
Decreased platelet count	Stem Cell Exhaustion	Peripheral stem cell transplantation in a child with amegakaryocytic thrombocytopenia.	11019849
Congenital amegakaryocytic thrombocytopenia	Stem Cell Exhaustion	We present a 13-month-old girl who was diagnosed as having congenital amegakaryocytic thrombocytopenia and was successfully treated with allogeneic peripheral stem cell transplantation (PSCT) from her fully matched sibling donor.	11019849
Neoplasms, Cholangiocarcinoma	Stem Cell Exhaustion	It is suggested that this tumor could arise from a multipotential stem cell and showed neuroendocrine and glandular differentiation and that Clonorchis sinensis could be a predisposing factor, as in cholangiocarcinoma.	11020854
Neoplasm Metastasis	Stem Cell Exhaustion	[Secondary solid tumors in autologous-peripheral blood stem cell transplantation recipients].	11020988
Acute lymphocytic leukemia, Hodgkin Disease, Multiple Myeloma, Myeloid Leukemia, Chronic, Lymphoma, Non-Hodgkin, Neoplasms, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We investigated the incidence of post-transplant solid tumors in a cohort of 109 patients who had undergone auto-peripheral blood stem cell transplantation (PBSCT) for acute myelogenous leukemia (n = 18), acute lymphoblastic leukemia (n = 7), non-Hodgkin's lymphoma (n = 52), Hodgkin's disease (n = 5), multiple myeloma (n = 16), chronic myelogenous leukemia (n = 1), myelodysplastic syndrome (n = 3) and solid tumors (n = 7).	11020988
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	[Autologous transplantation of Ph-negative peripheral blood stem cells for treatment of chronic myelogenous leukemia].	11020996
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	These observations suggest that Ph-negative progenitor cells can be harvested using a mini-ICE regimen followed by G-CSF, and that autologous PBSC transplantation is feasible in patients with CML resistant to IFN.	11020996
Lymphoma	Stem Cell Exhaustion	[Successful hematologic reconstitution using CD34+ cells positively selected from cryopreserved autologous peripheral blood stem cells in a patient with malignant lymphoma].	11020998
Non-hodgkin lymphoma of colon	Stem Cell Exhaustion	Primary non-Hodgkin's lymphoma of the mandible treated with radiotherapy, chemotherapy, and autologous peripheral blood stem cell transplantation.	11027381
Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	A 48-year-old Japanese man with NHL of the mandible received radiotherapy, followed by high-dose chemotherapy supported with peripheral blood stem cell transplantation (PBSCT).	11027381
Neoplasms	Stem Cell Exhaustion	Positive and negative selection to reduce tumour contamination in peripheral blood stem cell harvests.	11027980
Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	Peripheral blood progenitor cells used during high dose treatments for malignancy may be contaminated with tumour cells that could later contribute to recurrence.	11027980
Peripheral Blood Stem Cells, Venoocclusive disease	Stem Cell Exhaustion	Application of nitric oxide for a case of veno-occlusive disease after peripheral blood stem cell transplantation.	11033737
Acute lymphocytic leukemia	Stem Cell Exhaustion	A 5-year-old girl at high risk for acute lymphoblastic leukemia was treated with high-dose chemotherapy and autologous peripheral blood stem cell transplantation (PBSCT).	11033737
Gastrointestinal Stromal Tumors	Stem Cell Exhaustion	To test the hypothesis that GISTs originate from CD34-positive stem cells and differentiate toward an ICC phenotype.	11035578
Gastrointestinal Stromal Tumors	Stem Cell Exhaustion	The results of this study suggest that GISTs originate from CD34-positive stem cells and differentiate toward pacemaker cell phenotype.	11035578
Gastrointestinal Stromal Tumors, Gastrointestinal Stromal Sarcoma	Stem Cell Exhaustion	The lack of expression of CD34 in the benign GIST may indicate that benign GISTs are composed of more mature ICCs, whereas malignant GISTs are composed of dedifferentiated ICCs that express CD34-positive stem cells.	11035578
Pfaundler-Hurler Syndrome	Stem Cell Exhaustion	Fludarabine-based protocol for haploidentical peripheral blood stem cell transplantation in Hurler syndrome.	11037855
Pfaundler-Hurler Syndrome	Stem Cell Exhaustion	To assess the feasibility of performing a haploidentical peripheral blood stem cell transplantation (PBSCT) in a child with Hurler syndrome after a novel conditioning regimen consisting of fludarabine monophosphate, anti-T-lymphocyte globulin, low-dose busulfan, and single-dose total body irradiation of 750 cGy.	11037855
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The use of ara-C + TBI supported by peripheral blood progenitor cells should make the treatment safer and more widely applicable in AML.	11038038
Malignant Neoplasms	Stem Cell Exhaustion	In 16 patients with malignancies, serum-soluble c-Kit levels and the expressions of c-KIT messenger RNA (mRNA) and protein in peripheral blood mononuclear cells were analyzed serially during 26 courses of peripheral blood stem cell (PBSC) mobilization after granulocyte colony-stimulating factor administration following chemotherapy for PBSC harvest.	11039667
Neutropenia	Stem Cell Exhaustion	Hematopoietic colony-stimulating factors (CSF) decrease the duration of neutropenia following stem cell transplantation (SCT).	11041569
Perforation (observation), Appendicitis, CTCAE	Stem Cell Exhaustion	Eight months after high dose chemotherapy followed by autologous peripheral blood stem cell transplantation, acute appendicitis with perforation occurred and the patient underwent appendectomy.	11042526
Childhood Breast Carcinoma	Stem Cell Exhaustion	Use of the anti-idiotype antibody vaccine TriAb after autologous stem cell transplantation in patients with metastatic breast cancer.	11042653
Chemosensitivity	Stem Cell Exhaustion	Between April 1997 and March 1998 we evaluated the immune response and outcome in 11 chemosensitive patients who were treated with the anti-idiotype antibody vaccine TriAb after recovery from intensive therapy and autologous stem cell transplant (ASCT).	11042653
Toxic effect, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Feasibility and toxicity of high-dose chemotherapy supported by peripheral blood stem cell transplantation in elderly patients (>/=60 years) with non-Hodgkin's lymphoma: comparison with patients <60 years treated within the same protocol.	11042654
Lymphoma, Non-Hodgkin, Familial, Toxic effect, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Limited data are available concerning feasibility and toxicity of progenitor cell mobilization and high-dose therapy (HDT) supported by peripheral blood stem cell transplantation (PBSCT) in elderly patients (>/=60 years) with non-Hodgkin's lymphoma (NHL).	11042654
Lymphoma, Non-Hodgkin, Familial, Toxic effect	Stem Cell Exhaustion	The feasibility and toxicity of progenitor cell mobilization and HDT in the elderly patients were compared with experiences in 62 NHL patients <60 years (median 46 years, range 16-59), who received the same mobilization protocol and of whom 48 patients received HDT supported by PBSCT.	11042654
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	We conclude that progenitor cell mobilization and HDT supported by PBSCT is also feasible in selected elderly patients with NHL.	11042654
Chronic active Epstein-Barr virus infection	Stem Cell Exhaustion	Allogeneic peripheral blood stem cell transplantation for the treatment of chronic active Epstein-Barr virus infection.	11042666
Communicable Diseases	Stem Cell Exhaustion	Human herpesvirus 6 infection after autologous or allogeneic stem cell transplantation: a single-center prospective longitudinal study of 92 patients.	11049765
Communicable Diseases	Stem Cell Exhaustion	To determine the incidence and clinical relevance of active human herpesvirus 6 (HHV-6) infection, 92 consecutive unselected recipients of autologous or allogeneic stem cell grafts were investigated in a prospective longitudinal study.	11049765
PAFAH1B1 wt Allele	Stem Cell Exhaustion	A multistep pathogenesis caused by a clonal stem cell defect affecting several differentiation pathways has been proposed for MDS.	11053613
PAFAH1B1 wt Allele	Stem Cell Exhaustion	These data are consistent with dysmegakaryocytopoiesis and a defect in thrombocytopoiesis among MDS patients resulting from the clonal stem cell defect in MDS.	11053613
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Feasibility and recent improvement of autologous stem cell transplantation for acute myelocytic leukaemia in patients over 60 years of age: importance of the source of stem cells.	11054076
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) is a potential therapeutic approach in patients with AML over 60 years of age; results have improved recently.	11054076
Hematologic Neoplasms	Stem Cell Exhaustion	Bone marrow or stem cell transplantation is an established therapy for haematological malignancies.	11054077
Multiple Myeloma, Cytomegaloviral colitis	Stem Cell Exhaustion	We report a cytomegalovirus (CMV) IgG +ve 56-year-old patient who underwent autologous rescue with CD34(+) selected peripheral blood stem cells as part of consolidation therapy for multiple myeloma and subsequently developed CMV colitis.	11054077
Aggressive course	Stem Cell Exhaustion	In 33 patients with sensitive aggressive disease who did not receive stem-cell transplantation, EFS was 19% at 36 months.	11054436
Fever	Stem Cell Exhaustion	A total of 143 fever episodes during 113 consecutive hospitalizations were studied in 71 patients who had been referred for chemotherapy or haemopoietic stem cell transplantation (HSCT).	11055657
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The influence of amifostine used alone or in combination with 2-chlorodeoxyadenosine on normal and chronic myelogenous leukemia granulocyte-macrophage progenitor cells in vitro.	11059647
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We evaluated the influence of amifostine used alone or in combination with 2-chlorodeoxyadenosine (2-CdA) on the colony growth of normal and chronic myeloid leukemia (CML) granulocyte-macrophage progenitor cells (CFU-GM) in semisolid culture in vitro.	11059647
Graft-vs-Host Disease	Stem Cell Exhaustion	Our results show that it is feasible to induce graft-vs-host disease in the autologous stem cell transplantation setting.	11063870
leukemia	Stem Cell Exhaustion	Need for an accurate molecular diagnosis to assess the donor origin of leukemia relapse after allogeneic stem cell transplantation.	11064467
leukemia	Stem Cell Exhaustion	Leukemia relapse occurring in donor cells after allogeneic hematopoietic stem cell transplantation has been reported in rare cases.	11064467
Graft-vs-Host Disease, Neoplasms	Stem Cell Exhaustion	Allogeneic peripheral blood stem cell transplantation with CD34+ cell-selection (CD34+-PBSCT) allows rapid hematologic engraftment with a reduction in graft-versus-host disease (GVHD), although concerns exist regarding the increased risk of tumor relapse associated with T-cell depletion of the graft.	11064469
Merkel cell carcinoma	Stem Cell Exhaustion	Transient complete remission of metastasized Merkel cell carcinoma by high-dose polychemotherapy and autologous peripheral blood stem cell transplantation.	11069467
Multifocal, Angiomyolipoma	Stem Cell Exhaustion	The simultaneous presence of multiple angiomyolipoma nodules either inside or outside the glomeruli, multifocality and bilaterality of these lesions, together with the HMB-45 positivity and the finding of scattered epithelioid areas supports the theory that there is a progenitor cell giving origin to all these lesions, the cell which has been named as perivascular epithelioid cell by most authors.	11070127
Peripheral Blood Stem Cells, Myelosuppression, Toxic effect	Stem Cell Exhaustion	Profound myelosuppression was the major toxicity, but retreatment was possible by day 28, and preliminary results with peripheral blood stem cell collections showed a sparing effect on hemopoietic stem cells.	11070479
Maternal infection, White Matter Injury	Stem Cell Exhaustion	To explore the possible linkage between white matter injury and maternal infection, purified rat O-2A progenitor (Oligodendrocyte-type 2 astrocyte progenitor) cell cultures were used as a model in studying the effects of lipopolysaccharide (LPS), an endotoxin, on survival and differentiation of oligodendrocytes and the involvement of other glial cells in the effects of LPS.	11070494
CALD1 wt Allele	Stem Cell Exhaustion	O-2A progenitor cells were cultured from optic nerves of 7-day-old rat pups in a chemically defined medium (CDM).	11070494
Communicable Diseases	Stem Cell Exhaustion	The overall results indicate that astrocytes and microglia may promote viability and differentiation of O-2A progenitor cells under physiological conditions, but they may also mediate cytotoxic effects of LPS on oligodendrocytes under an infectious disease biochemical environment.	11070494
Juvenile Myelomonocytic Leukemia, Polycythemia Vera, Myeloproliferative disease	Stem Cell Exhaustion	Hematopoietic progenitor cells in 2 myeloproliferative disorders, juvenile chronic myelomonocytic leukemia and polycythemia vera, are known to be hypersensitive to cytokines that control normal progenitor cell proliferation, differentiation, and survival in their respective granulocyte/macrophage and erythroid lineages.	11071622
Thrombocytosis, Hypersensitivity	Stem Cell Exhaustion	Hypersensitivity of circulating progenitor cells to megakaryocyte growth and development factor (PEG-rHu MGDF) in essential thrombocythemia.	11071622
Thrombocytosis, Myeloproliferative disease	Stem Cell Exhaustion	Because thrombopoietin controls these functions in the normal megakaryocytic lineage, we asked the question: Are megakaryocytic progenitor cells in the myeloproliferative disorder essential thrombocythemia (ET) hypersensitive to thrombopoietin?	11071622
Chronic myeloproliferative disorder	Stem Cell Exhaustion	We propose that, despite their single pluripotential cell origin, the different clinicopathologic phenotypes in different chronic myeloproliferative disorders are determined by lineage-restricted hypersensitivities of hematopoietic progenitor cells to endogenous cytokines.	11071622
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	Peripheral blood B cells in patients with paroxysmal nocturnal hemoglobinuria (PNH) comprise variable mixtures of normal B cells produced before the onset of disease and glycosylphosphatidylinositol (GPI)-deficient B cells derived from the PNH hematopoietic stem cell.	11071650
Late Onset Disorders	Stem Cell Exhaustion	Treatment of late-onset patients and pre-symptomatic individuals (identified either because prenatal testing was not requested or a fetus predicted to be affected was not aborted) by hemato-poietic stem cell transplantation (HSCT) resulted in a less severe phenotype than was predicted and, in some cases, a significant delay in the onset of symptoms[4].	11074371
PAFAH1B1 wt Allele, Lymphoma	Stem Cell Exhaustion	Mutations of the c-kit proto-oncogene (stem cell factor receptor) and the p53 tumor-suppressor gene were examined in the MDS lesion and malignant lymphoma (ML) by the polymerase chain reaction-single-strand conformational polymorphism (PCR-SSCP) method followed by direct sequencing.	11074541
Disease, leukemia, Crohn Disease	Stem Cell Exhaustion	Allogeneic stem cell transplantation (SCT) performed for coincidental diseases is able to cure both leukaemia and Crohn's disease.	11081397
Small cell carcinoma of lung	Stem Cell Exhaustion	Intramedullary spinal cord recurrence after high-dose chemotherapy and autologous peripheral blood progenitor cell transplantation for limited-disease small cell lung cancer.	11086208
Small cell carcinoma of lung	Stem Cell Exhaustion	We describe here a patient with SCLC who developed intramedullary spinal cord recurrence after high-dose chemotherapy (HDCT) followed by autologous blood progenitor cell transplantation (ABPCT).	11086208
Malignant neoplasm of liver	Stem Cell Exhaustion	[Phase I study of super high-dose chemotherapy for liver cancer with percutaneous isolated hepatic perfusion (PIHP) and peripheral blood stem cell transplantation (PBSCT)].	11086416
Secondary malignant neoplasm of liver, Hollings Cancer Center	Stem Cell Exhaustion	In 4 patients with HCC and 1 patient with colonic liver metastases, peripheral blood stem cells (PBSC) were mobilized by either i.v.	11086416
Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	Successful stem cell transplantation following orthotopic liver transplantation from the same haploidentical family donor in a girl with hemophagocytic lymphohistiocytosis.	11090093
Liver Failure, Acute	Stem Cell Exhaustion	The patient underwent stem cell transplantation from her haploidentical mother 2 months after receiving a living-related liver transplant from the same donor for acute hepatic failure.	11090093
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Feasibility of peripheral blood stem cell rescue as intensification in elderly patients with acute myelocytic leukaemia: a pilot study from the Gimema Group.	11091221
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Elderly patients with untreated acute myeloid leukaemia (AML, n = 47) tested the feasibility of out-patient consolidation therapy and post-consolidation treatment (for patients aged < 71 years) with autologous peripheral blood stem cell transplantation (APBSCT).	11091221
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Peripheral blood stem cell mobilization with cyclophosphamide in combination with G-CSF, GM-CSF, or sequential GM-CSF/G-CSF in non-Hodgkin's lymphoma patients: a randomized prospective study.	11091498
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	We designed a randomized, prospective three-arm mobilization study to determine the kinetics of peripheral blood stem cell (PBSC) mobilization in 60 non-Hodgkin's lymphoma (NHL) patients primed with cyclophosphamide (CTX) in combination with granulocyte colony-stimulating factor (G-CSF) (arm A), granulocyte-macrophage (GM)-CSF (arm B) or GM-CSF/G-CSF (arm C).	11091498
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The aim of the study was to investigate the influence of gemcitabine (2',2'-difluorodeoxycytidine, dFdC) used alone and in combination with 2-chlorodeoxyadenosine (2-CdA) on the colony growth of normal granulocyte-macrophage progenitor cells (CFU-GM) from 15 hematologically healthy donors as well as on CFU-GM from 15 chronic myelogenous leukemia (CML) patients in semisolid cultures in vitro.	11092462
Connective Tissue Diseases	Stem Cell Exhaustion	Autologous peripheral blood stem cell transplantation in a patient with severe mixed connective tissue disease.	11093601
Mixed Connective Tissue Disease, Connective Tissue Diseases, Polymyositis	Stem Cell Exhaustion	A 65-year old man with mixed connective tissue disease (MCTD) and severe therapy resistant polymyositis was considered for high-dose cyclophosphamide (200 mg/kg) supported by autologous stem cell transplantation (ASCT).	11093601
Pemphigus Vulgaris	Stem Cell Exhaustion	Immunoablative high-dose cyclophosphamide without stem cell rescue in a patient with pemphigus vulgaris.	11100024
Autoimmune Diseases, paraneoplastic pemphigus, Lupus Erythematosus, Aplastic Anemia	Stem Cell Exhaustion	The use of ablative intravenous cyclophosphamide (50 mg/kg per day for 4 days) without stem cell rescue has been described in patients with refractory autoimmune diseases such as paraneoplastic pemphigus, systemic lupus erythematosus, and aplastic anemia.	11100024
Amyloidosis	Stem Cell Exhaustion	Blood stem cell transplantation as therapy for primary systemic amyloidosis (AL).	11100275
Chronic granulomatous disease, Aspergillosis	Stem Cell Exhaustion	Successful treatment of invasive aspergillosis in chronic granulomatous disease by granulocyte transfusions followed by peripheral blood stem cell transplantation.	11100285
Infection	Stem Cell Exhaustion	Cure of the disease can be achieved by stem cell transplantation when performed early in its course, and before severe infections have developed.	11100285
Chronic granulomatous disease, Pulmonary Aspergillosis, Osteomyelitis	Stem Cell Exhaustion	We report a 4-year-old boy with X-linked CGD who underwent successful HLA-identical peripheral blood stem cell (PBSC) transplantation during invasive pulmonary aspergillosis and osteomyelitis of the left fourth rib, which was unresponsive to antifungal treatment.	11100285
Chronic granulomatous disease	Stem Cell Exhaustion	Based on other reports and our own experience, GTX can serve as important treatment in patients with CGD who have failed conventional anti-fungal treatment and for whom stem cell transplantation is the only chance for cure.	11100285
Medial collateral ligament	Stem Cell Exhaustion	This report suggests a curative potential of allogeneic stem cell transplantation in MCL.	11100750
Multiple Myeloma	Stem Cell Exhaustion	High-dose idarubicine, busulphan and melphalan as conditioning for autologous blood stem cell transplantation in multiple myeloma.	11108301
Malignant Neoplasms	Stem Cell Exhaustion	This paper summarizes a pilot, sequential dose-escalation study of PEG-rHuMGDF in patients with advanced malignancies who had delayed platelet recovery after autologous stem cell transplantation (ASCT).	11108307
Aplastic Anemia	Stem Cell Exhaustion	A 23-year-old male suffering from severe aplastic anemia (SAA) weighing 60 kg was successfully treated by unrelated allo-CBSCT (cord blood stem cell transplantation).	11108315
Febrile Neutropenia	Stem Cell Exhaustion	Penicillin or vancomycin plus ceftazidime in febrile neutropenic patients after stem cell transplantation.	11109643
Malignant neoplasm of testis, leukaemia secondary	Stem Cell Exhaustion	[Secondary leukemia following ultra high-dose chemotherapy with peripheral blood stem cell autotransplantation for refractory testicular cancer].	11109821
Peripheral Stem Cell Transplantation, Seminoma, Malignant neoplasm of testis, Choriocarcinoma, Neoplasms, Embryonal Carcinoma, leukaemia secondary	Stem Cell Exhaustion	We report a case of secondary leukemia occurring in a 31-year-old man who received ultra high-dose chemotherapy with peripheral blood stem cell autotransplantation (PBSCT) for a refractory testicular cancer (pathology; Seminoma, Embryonal carcinoma, Yolk sac tumor, Choriocarcinoma) with IIIB2 under Japanese classification, poor-risk group under Indiana classification.	11109821
Cessation of life, Failure, Primary graft failure	Stem Cell Exhaustion	Among patients surviving at least 28 days, 4% had primary graft failure (failure to achieve an absolute neutrophil count > 5 x 10(8)/L before death or second stem-cell infusion).	11110679
Hematoxylin and eosin stain method	Stem Cell Exhaustion	Disease-free survival after high-dose chemotherapy with stem cell replacement or autologous bone marrow transplantation was stratified into three groups based on hematoxylin and eosin (H&E) staining and IHC results.	11117779
Mycoses, Acute leukemia	Stem Cell Exhaustion	To determine whether a polymerase chain reaction (PCR)-based assay enabled the identification of patients at risk for invasive fungal infections, a prospective monitoring once per week was performed during 92 neutropenic episodes in patients receiving chemotherapy for acute leukaemia or high-dose therapy followed by allogeneic or autologous stem cell transplantation, with the investigators blinded to clinical and microbiological data.	11122112
Myeloproliferative disease	Stem Cell Exhaustion	Translocations affecting the chromosomal locus 8p12 are hallmarks of an atypical stem cell myeloproliferative disorder.	11122115
Graft-vs-Host Disease	Stem Cell Exhaustion	Clinical course and predictive factors for cyclosporin-induced autologous graft-versus-host disease after autologous haematopoietic stem cell transplantation.	11122133
Autoimmune reaction, Graft-vs-Host Disease	Stem Cell Exhaustion	The administration of cyclosporin A (CyA) after autologous haematopoietic stem cell transplantation (HSCT) induces a systemic autoimmune syndrome mimicking graft-vs.-host disease (GVHD).	11122133
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GVHD) remains a significant complication in patients undergoing allogeneic stem cell transplantation (SCT) using a reduced intensity conditioning regimen.	11122140
Histogenic Process, Carcinosarcoma	Stem Cell Exhaustion	Carcinosarcoma with rhabdoid features of the urinary bladder in a 2-year-old girl: possible histogenesis of stem cell origin.	11123764
Carcinosarcoma, Neoplasms	Stem Cell Exhaustion	The extremely young age at which this case of carcinosarcoma occurred suggests that the tumor may be of mesodermal stem cell origin.	11123764
Hypocalcemia, Hypokalemia	Stem Cell Exhaustion	Clinically relevant hypokalaemia, hypocalcaemia, and loss of hemoglobin and platelets during stem cell apheresis.	11124690
Hypocalcemia	Stem Cell Exhaustion	In addition to the well-documented citrate-induced hypocalcaemia, we observed a considerable reduction in serum potassium during stem cell apheresis.	11124690
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Immunotherapy with rituximab during peripheral blood stem cell transplantation for non-Hodgkin's lymphoma.	11128813
Lymphoma	Stem Cell Exhaustion	Peripheral blood stem cell grafts from patients with lymphoma are often contaminated with neoplastic cells.	11128813
Neoplasms	Stem Cell Exhaustion	As determined with a sensitive polymerase chain reaction assay, 6 of 7 stem cell products tested were free of tumor contamination.	11128813
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Rituximab used as an in vivo purging agent and adjuvant immunotherapy with peripheral blood stem cell transplantation for non-Hodgkin's lymphoma is a well-tolerated regimen.	11128813
Mantle cell lymphoma	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation for mantle cell lymphoma.	11128815
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	This study evaluated the outcomes of patients who underwent high-dose chemotherapy (HDC) and autologous hematopoietic stem cell transplantation (autoHSCT) for mantle cell non-Hodgkin's lymphoma and the effect of clinical and treatment characteristics.	11128815
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	These encouraging results suggest that in patients lacking a sibling donor, unrelated donor BMT for AML in remission achieves survival figures as good as or better than those reported on patients with autologous stem cell transplantation, and that T-cell depletion of grafts is associated with a low relapse rate and an excellent functional status.	11128816
Hematological Disease	Stem Cell Exhaustion	Recovery after stem-cell transplantation for hematologic diseases.	11134219
Multiple Myeloma	Stem Cell Exhaustion	A 59-year-old man with a 4-year history of light chain myeloma relapsing after two preceding autografts and salvage therapy with thalidomide underwent a peripheral blood stem cell (PBSC) transplant from his HLA-identical sister after conditioning with 100 mg/m2 melphalan.	11149738
Allogeneic Hematopoietic Stem Cell Transplantation, Kaposi Sarcoma, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Kaposi's sarcoma following allogeneic hematopoietic stem cell transplantation for chronic myelogenous leukemia.	11154986
Kaposi Sarcoma	Stem Cell Exhaustion	Unlike solid organ transplantation, Kaposi's sarcoma (KS) occurs rarely following hematopoietic stem cell transplantation (HSCT).	11154986
Neoplasms	Stem Cell Exhaustion	Detection of germ-cell tumor cells in peripheral blood progenitor cell harvests: impact on clinical outcome.	11156214
Neoplasms	Stem Cell Exhaustion	Our study was conducted to evaluate the impact of tumor cell contamination in peripheral blood progenitor cell (PBPC) harvests on the clinical outcome of patients with germ-cell tumors undergoing high-dose chemotherapy (HDCT) and autologous PBPC reinfusion.	11156214
germ cell nucleus, Neoplasms	Stem Cell Exhaustion	Samples of mononuclear cells from progenitor cell harvests of 57 patients with advanced or recurrent germ-cell tumors were retrospectively screened for contaminating tumor cells using immunocytochemical staining for cytokeratin filaments and reverse transcription-PCR (RT-PCR) testing for germ-cell alkaline phosphatase mRNA.	11156214
Hematologic Neoplasms	Stem Cell Exhaustion	Melphalan and purine analog-containing preparative regimens: reduced-intensity conditioning for patients with hematologic malignancies undergoing allogeneic progenitor cell transplantation.	11157478
Cytomegalovirus Infections	Stem Cell Exhaustion	To determine the risk factors and outcomes associated with rising cytomegalovirus (CMV) antigenemia levels during preemptive therapy among stem cell allograft recipients, 119 patients with CMV antigenemia were studied.	11159510
Paroxysmal nocturnal hemoglobinuria, Bone Marrow Failure Disorders, Aplastic Anemia	Stem Cell Exhaustion	To study the turnover of stem cells in patients with bone marrow failure syndromes, the telomere length in peripheral blood granulocytes and lymphocytes from patients with aplastic anemia (AA, n = 56) and hemolytic paroxysmal nocturnal hemoglobinuria (n = 6) was analyzed relative to age-matched controls by means of fluorescence in situ hybridization and flow cytometry.	11159514
Aplastic Anemia	Stem Cell Exhaustion	FL is mobilized from the cytoplasmic stores and its serum levels are massively increased during the period of bone marrow aplasia after stem cell transplantation (SCT).	11159533
Fanconi Anemia	Stem Cell Exhaustion	Stem cell transplantation for the treatment of Fanconi anaemia using a fludarabine-based cytoreductive regimen and T-cell-depleted related HLA-mismatched peripheral blood stem cell grafts.	11167755
Fanconi Anemia	Stem Cell Exhaustion	We have employed a new cytoreductive regimen to transplant two patients with Fanconi anaemia (FA), using T cell-depleted two HLA-allele disparate related peripheral blood stem cell transplants (PBSCTs).	11167755
Fanconi Anemia	Stem Cell Exhaustion	In summary, we report two successful T-cell-depleted stem cell transplants from mismatched related donors for the treatment of Fanconi anaemia, using a fludarabine-based cytoreduction.	11167755
Aplastic Anemia	Stem Cell Exhaustion	Mechanisms of bone marrow progenitor cell apoptosis in aplastic anaemia and the effect of anti-thymocyte globulin: examination of the role of the Fas-Fas-L interaction.	11167757
T-Cell Large Granular Lymphocyte, PAFAH1B1 wt Allele, Abnormality of red blood cells	Stem Cell Exhaustion	The lower response rate of MDS or T-LGL/MDS to immunosuppression, compared with T-LGL alone, may reflect the older age and intrinsic stem cell abnormalities in MDS and T-LGL/MDS patients.	11167802
Cytomegalovirus Infections, Fever, Multiple Myeloma	Stem Cell Exhaustion	Cytomegalovirus infection and non-neutropenic fever after autologous stem cell transplantation: high rates of reactivation in patients with multiple myeloma and lymphoma.	11167810
Hematologic Neoplasms, Fever, Neoplasms, Communicable Diseases	Stem Cell Exhaustion	In a retrospective study, we examined the association between cytomegalovirus (CMV) infection and non-neutropenic fever immediately following autologous peripheral blood stem cell transplantation for a variety of haematological malignancies and solid tumours.	11167810
Thrombocytosis, Polycythemia Vera	Stem Cell Exhaustion	Haemopoietic stem cell transplantation for advanced polycythaemia vera or essential thrombocythaemia.	11167837
Thrombocytosis, Polycythemia Vera, Fred Hutchinson/University of Washington Cancer Consortium	Stem Cell Exhaustion	Ten patients with polycythaemia vera (PV) and nine with essential thrombocythaemia (ET) received a haemopoietic stem cell transplant (HSCT) at the Fred Hutchinson Cancer Research Center between May 1988 and March 2000.	11167837
Fever	Stem Cell Exhaustion	There is currently no predictive assay to determine which patients treated with high-dose cyclophosphamide have a high risk of febrile aplasia or will successfully undergo cytaphereses for stem cell collection.	11167839
Fanconi Anemia	Stem Cell Exhaustion	Fludarabine-based stem cell transplantation protocol for Fanconi's anaemia in myelodysplastic transformation.	11167843
Failure, Fanconi Anemia, FANCA wt Allele	Stem Cell Exhaustion	Allogeneic stem cell transplantation (SCT) represents the treatment of choice for severe bone marrow (BM) failure in patients with Fanconi's anaemia (FA).	11167843
Hodgkin Disease, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Allogeneic or autologous stem cell transplantation (SCT) for relapsed and refractory Hodgkin's disease and non-Hodgkin's lymphoma: a single-centre experience.	11168507
Lymphoma	Stem Cell Exhaustion	The aim of the study was to evaluate which patient might benefit most from allogeneic stem cell transplantation (SCT) in the treatment of relapsed and/or refractory lymphoma.	11168507
Lymphoma	Stem Cell Exhaustion	Thirty-eight consecutive lymphoma patients receiving either autologous (n = 24) or allogeneic (n = 14) stem cell grafts at our institution from 1986 to 1998 were retrospectively analysed regarding overall survival (OS), disease-free survival (DFS), transplant-related mortality (TRM), and relapse incidence (RI).	11168507
Graft-vs-Host Disease	Stem Cell Exhaustion	An ethnic role for chronic, but not acute, graft-versus-host disease after HLA-identical sibling stem cell transplantation.	11168508
leukemia	Stem Cell Exhaustion	Treatment of T-prolymphocytic leukemia with nonmyeloablative allogeneic stem cell transplantation.	11168523
Neoplasms	Stem Cell Exhaustion	We believe this neoplasm originated from pluripotent stem cells destined to become sebaceous stem cells or from sebaceous stem cells, which also have the ability to differentiate within apocrine glands.	11176053
Fever	Stem Cell Exhaustion	High-dose chemotherapy followed by reinfusion of a high number of CD34+ progenitor cells is frequently associated with development of fever in the postengraftment period.	11177596
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The functional characteristics were compared for acute myelogenous leukemia (AML) cells (native blasts and AML cell lines) cultured in three serum-free media (X-vivo 10, X-vivo 15, [Bio-Whitacker, Walkersville, MD] and StemSpan [Stem Cell Technologies, Vancouver, BC, Canada]) and in medium containing 10% inactivated fetal calf serum (FCS).	11177606
Childhood Breast Carcinoma, Morbidity - disease rate	Stem Cell Exhaustion	Low infectious morbidity after intensive chemotherapy and autologous peripheral blood progenitor cell transplantation in the outpatient setting for women with breast cancer.	11181116
Malignant neoplasm of gastrointestinal tract	Stem Cell Exhaustion	Long-term results of a phase-II-pilot trial on preoperative high-dose chemotherapy with stem cell rescue in patients with cancer of the upper gastrointestinal tract.	11182052
Malignant neoplasm of gastrointestinal tract	Stem Cell Exhaustion	We have tested the feasibility, tolerability, and efficacy of a multimodality treatment approach for patients with locally advanced cancer of the upper gastrointestinal tract including preoperative chemotherapy with the EAP-protocol as induction and a consecutive high-dose chemotherapy with MCVB and autologous stem cell rescue for responding patients.	11182052
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	One possible explanation for the competitive advantage that malignant cells in patients with acute myelogenous leukemia (AML) appear to have over normal hematopoietic elements is that leukemic progenitors proliferate more rapidly than their normal progenitor cell counterparts.	11187903
Acute lymphocytic leukemia	Stem Cell Exhaustion	[Retardation of platelet recovery after autologous stem cell transplantation in a patient with acute lymphoblastic leukemia: possible role of decreased thrombopoietin production by bone marrow stromal cells].	11193436
Acute lymphocytic leukemia	Stem Cell Exhaustion	A 16-year-old boy was diagnosed as having acute lymphoblastic leukemia and underwent autologous stem cell transplantation at the time of his second complete remission.	11193436
Neoplasms, Fibrous Tissue, Neoplasms	Stem Cell Exhaustion	Localized fibrous tumor of the pleura is a rare, slowly growing, benign tumor which originates from the submesothelial stem cells of the pleura visceralis.	11195068
Multiple Myeloma	Stem Cell Exhaustion	Despite the use of high-dose chemotherapy with autologous hematopoietic stem cell transplantation, multiple myeloma remains largely uncurable.	11195707
Leukemia, Myelomonocytic, Chronic, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We report our experience with allogeneic peripheral blood stem cell transplantation (allo-PBSCT) following a nonmyeloablative conditioning regimen consisting of cytarabine (8 g/m2) and cyclophosphamide (120 mg/kg) in the treatment of 2 patients aged 50 and 55 years with refractory chronic myelomonocytic leukemia and chronic myeloid leukemia in accelerated phase, respectively.	11197220
Childhood Breast Carcinoma	Stem Cell Exhaustion	Methotrexate, uracil and tegafur, and leucovorin chemotherapy for patients with breast cancer in progression after high-dose chemotherapy with peripheral blood progenitor cell transplant: a phase II study.	11202810
mecarzole, Childhood Breast Carcinoma	Stem Cell Exhaustion	Thirty-four patients with metastatic breast cancer (MBC) who had progression of disease after high-dose chemotherapy (HDCT) with peripheral blood progenitor cell support (PBPC) had methotrexate, uracil and tegafur (UFT), and leucovorin (MUL) therapy administered: methotrexate administered intramuscularly in combination with UFT given orally and leucovorin given orally.	11202810
Lymphoma, Follicular	Stem Cell Exhaustion	High-dose therapy with autologous stem-cell transplantation (ASCT) after first progression prolonged survival of follicular lymphoma patients included in the prospective GELF 86 protocol.	11205467
Aggressive Non-Hodgkin Lymphoma, Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	To evaluate the results of high-dose chemotherapy and autologous hematopoietic stem-cell transplantation (autotransplants) in patients with diffuse aggressive non-Hodgkin's lymphoma (NHL) who never achieve a complete remission with conventional chemotherapy.	11208832
Aggressive course	Stem Cell Exhaustion	High-dose chemotherapy and autologous hematopoietic stem-cell transplantation should be considered for patients with diffuse aggressive NHL who never achieve a complete remission but who are still chemotherapy-sensitive and are otherwise transplant candidates.	11208832
Cessation of life	Stem Cell Exhaustion	Despite the low frequency of marrow involvement in nasal NK cell lymphoma, EBER ISH is worthwhile to identify the minor subgroup of patients with a high likelihood of early death due to disease and when autologous bone marrow or peripheral blood stem cell transplantation is contemplated.	11211616
Autoimmune thrombocytopenia	Stem Cell Exhaustion	To our knowledge, this agent has not been used in the treatment of autoimmune thrombocytopenia, since theoretically there is a danger of IL-11 stimulating the immune system by up-regulating the lymphoid stem cells.	11212156
Idiopathic pneumonia syndrome, Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	To report the outcome as well as the clinical, radiographic, and pathologic features of idiopathic pneumonia syndrome (IPS) following autologous peripheral blood stem cell transplantation (aPBSCT).	11215840
Acute lymphocytic leukemia	Stem Cell Exhaustion	We report a 5.5-year-old boy who underwent autologous peripheral blood stem cell transplantation for high-risk acute lymphoblastic leukemia and who had two abdominal masses develop 6 months later.	11216708
Anemia, Sickle Cell	Stem Cell Exhaustion	Improved cerebrovascular patency following therapy in patients with sickle cell disease: initial results in 4 patients who received HLA-identical hematopoietic stem cell allografts.	11220742
Hematologic Neoplasms, PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is characterized by an acquired clonal disorder of haematopoietic progenitor cells that results in inhibition of normal haematopoiesis and contributes to the development of haematological malignancies.	11221999
Cryofibrinogenemia, Skin necrosis	Stem Cell Exhaustion	Cryofibrinogenemia and skin necrosis in a patient with diffuse large cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation.	11223976
Skin necrosis	Stem Cell Exhaustion	A 34-year-old woman with diffuse mediastinal B cell large cell lymphoma presented 60 days after high-dose chemotherapy and autologous stem cell transplantation, and post-transplant immunotherapy with interleukin-2, with skin necrosis in the ears and extremities.	11223976
Burkitt Lymphoma	Stem Cell Exhaustion	Allogeneic stem cell transplantation in a patient with refractory Burkitt's lymphoma using non-myeloablative conditioning regimen.	11223978
Burkitt Lymphoma	Stem Cell Exhaustion	We have performed an allogeneic stem cell transplant in an 18-year-old male patient who had Burkitt's lymphoma.	11223978
Myelitis, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Radiation myelitis following allogeneic stem cell transplantation and consolidation radiotherapy for non-Hodgkin's lymphoma.	11223979
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	We describe the case of a 38-year-old man with refractory non-Hodgkin's lymphoma who underwent matched sibling peripheral blood stem cell transplant following a conditioning regimen of cyclophosphamide (60 mg/kg x 2) and total body irradiation (120 cGy x 11).	11223979
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	AC133 expression on acute myeloid leukemia blasts: correlation to FAB and to CD34 expression and possible implications for peripheral blood progenitor cell purging in AML.	11226513
Stem Cell Factor	Stem Cell Exhaustion	In summary, our results show that the combination of cyclophosphamide, G-CSF and SCF is highly effective for stem cell mobilization, with differences observed in the mobilization kinetics of the different hematopoietic cell subsets analyzed.	11237067
Gastrointestinal Stromal Tumors	Stem Cell Exhaustion	It has recently been proposed that gastrointestinal stromal tumors (GISTs) originate from stem cells that differentiate toward a phenotype of interstitial cells of Cajal (ICCs).	11238030
Neoplasms	Stem Cell Exhaustion	Nestin is a newly identified intermediate filament protein, and is predominantly expressed in immature cells, such as neuroectodermal stem cells and skeletal muscle progenitor cells, and tumors originating from these cells.	11238030
Gastrointestinal Stromal Tumors, Neoplasms	Stem Cell Exhaustion	These results show that nestin may be a useful marker for diagnosis of GISTs, and support the current hypothesis that GISTs are tumors of stem cells that differentiate toward an ICC phenotype.	11238030
Neutropenia, Aspergillosis	Stem Cell Exhaustion	Screening for circulating galactomannan as a noninvasive diagnostic tool for invasive aspergillosis in prolonged neutropenic patients and stem cell transplantation recipients: a prospective validation.	11238098
Lymphotoxin-Alpha, human	Stem Cell Exhaustion	The effect of the p55 sTNFR (recombinant TNF-binding protein-1 [rTBP-1]) on the clonogenic growth of hematopoietic progenitor cells from 27 HIV-infected patients was evaluated in comparison with 11 normal study subjects.	11242177
Hematological Disease	Stem Cell Exhaustion	[Treatment of malignant hematological diseases with autologous peripheral blood stem cell transplantation].	11243112
Hematological Disease	Stem Cell Exhaustion	To observe the effectiveness of autologous peripheral blood stem cell transplantation(ABSCT) in the treatment of malignant hematologic diseases.	11243112
Hematologic Neoplasms	Stem Cell Exhaustion	Thirteen ABSCT and 15 autologous peripheral blood stem cells(ABSC) combining autologous bone marrow transplantation (ABMT) were performed for hematological malignancy patients.	11243112
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Proliferating status of peripheral blood progenitor cells from patients with BCR/ABL-positive chronic myelogenous leukemia.	11243401
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	To investigate the mechanisms behind the leukemic expansion of BCR/ABL-positive chronic myelogenous leukemia (CML), we examined the cell cycle status of hematopoietic progenitor cells from peripheral blood (PB) and bone marrow (BM) of 37 patients with newly diagnosed BCR/ABL-positive CML.	11243401
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Interestingly, CD34+ hematopoietic progenitor cells from BM remained proliferating in five cases examined, indicating that CML PBPC are more easily inhibited by STI571 as compared to CD34+ CML hematopoietic progenitor cells from BM.	11243401
Adult Angiosarcoma	Stem Cell Exhaustion	Immunohistological distribution of stem cell factor and kit receptor in angiosarcoma.	11243641
Adult Angiosarcoma, Neoplasms	Stem Cell Exhaustion	Immunohistological localization of stem cell factor, a mast cell growth factor, demonstrated that stem cell factor-positive cells occurred in the tumors forming the vascular lumen in nodular-type angiosarcoma.	11243641
Adult Angiosarcoma, Neoplasms	Stem Cell Exhaustion	In macular angiosarcoma, stem cell factor was also detected in the tumor vascular endothelial cells.	11243641
Adult Angiosarcoma, Neoplasms	Stem Cell Exhaustion	These results suggest that tumor cell-derived stem cell factor may play a role in the increased number of mast cells, via the kit receptor, which may contribute to the proliferation of tumor cells, leading to the progression of angiosarcoma.	11243641
Hematologic Neoplasms	Stem Cell Exhaustion	Although high-dose therapy with autologous hematopoietic stem cell transplantation (ASCT) is a widely used method of dose intensification in patients with hematological malignancies, patients aged over 60 are generally excluded.	11244434
Angioendotheliomatosis	Stem Cell Exhaustion	Successful autologous peripheral blood stem cell transplantation for relapsed intravascular lymphomatosis.	11244443
Data Type Interval	Stem Cell Exhaustion	Our case suggests that PBSC is acceptable as a source for stem cell rescue in IVL.	11244443
Fatty replacement of ventricular myocardial tissue, Acute heart failure	Stem Cell Exhaustion	Acute heart failure after allogeneic blood stem cell transplantation due to massive myocardial infiltration by cytotoxic T cells of donor origin.	11244447
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 17-year-old male with AML FAB M4 relapsed 4 months after myeloablative conditioning and peripheral blood stem cell transplantation (PBSCT) from an HLA-identical unrelated donor.	11244447
Aplastic Anemia	Stem Cell Exhaustion	Transplantation of CD34-enriched peripheral stem cells from an HLA-haplotype mismatched donor to a patient with severe aplastic anemia.	11244448
leukemia	Stem Cell Exhaustion	Possible clinical benefits of the use of peripheral blood stem cells over bone marrow in the allogeneic transplantation setting for the treatment of childhood leukemia.	11256838
Hereditary Breast and Ovarian Cancer Syndrome	Stem Cell Exhaustion	Thirty-four ovarian and breast cancer patients received autologous peripheral blood progenitor cell transplantation after high-dose myeloablative chemotherapy and either granulocyte-colony-stimulating factor (G-CSF) or granulocyte/macrophage-colony-stimulating fictor (GM-CSF) in the immediate post-transplant period.	11258790
Anemia, Sideroblast	Stem Cell Exhaustion	Apoptosis in refractory anaemia with ringed sideroblasts is initiated at the stem cell level and associated with increased activation of caspases.	11260077
Refractory anemia with ringed sideroblasts	Stem Cell Exhaustion	Thus, erythroid apoptosis in RARS is initiated at the CD34+ level and growth factor treatment may improve stem cell function.	11260077
Refractory anemia with ringed sideroblasts	Stem Cell Exhaustion	Enhanced caspase activation at the stem cell level, albeit not mediated through endogenous activation of the Fas receptor, contributes to the erythroid apoptosis in RARS.	11260077
Pericarditis, CTCAE	Stem Cell Exhaustion	Pericarditis after allogeneic peripheral blood stem cell transplantation caused by Legionella pneumophila (non-serogroup 1).	11261761
Pericarditis, CTCAE	Stem Cell Exhaustion	A case of Legionella pericarditis caused by a Legionella pneumophila isolate other than serogroup 1 is reported in a 59-year-old man after allogeneic peripheral blood stem cell transplantation.	11261761
Lesion, Cerebral calcification	Stem Cell Exhaustion	Allogeneic bone marrow stem cell replacement cures the osteoclast component of CAII deficiency and retards the development of cerebral calcification, but it appears to have little or no effect on the renal lesions.	11264157
pseudomonas sepsis	Stem Cell Exhaustion	He died with Pseudomonas septicemia during the waiting period for a bone marrow transplantation from a cord-blood stem cell.	11270473
Post-transplant lymphoproliferative disorder, Lymphoproliferative Disorders	Stem Cell Exhaustion	In contrast to solid organ transplantation (Tx), the incidence of post-transplant lymphoproliferative disease (PTLD) after hematopoietic stem cell Tx (HSCT) is generally low.	11272609
Stem Cell Factor	Stem Cell Exhaustion	Mutant c-kit cDNA was transfected into 293T human embryonic kidney cells and the magnitude of autophosphorylation of the mutant KIT was examined with or without the ligand of KIT, stem cell factor (SCF).	11276010
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Furthermore, the detection of VEGF in peripheral blood stem cell (PBSC) autografts suggests that VEGF may influence the proliferation and possibly also the survival of contaminating AML cells in PBSC autografts.	11276362
Neoplasms, Peripheral Stem Cell Transplantation, Specialty Type - cancer	Stem Cell Exhaustion	Co-mobilization of CD34(+) cells and tumor has been documented in patients with different types of cancer undergoing peripheral blood stem cell transplantation (PBSCT).	11276370
Hematologic Neoplasms, Communicable Diseases	Stem Cell Exhaustion	We describe nine patients with hematological malignancies (five having undergone either allogeneic or autologous stem cell transplantation) identified as having PIV3 infection during a 2-month period in a Hematology Unit.	11277177
Serum phosphate concentration below normal	Stem Cell Exhaustion	Engraftment-associated hypophosphatemia--the role of cytokine release and steep leukocyte rise post stem cell transplantation.	11277180
Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	Blood samples were obtained from 60 patients undergoing peripheral blood stem cell transplant, on the day of admission and then daily from the day of transplant until discharge.	11277180
Peripheral Blood Stem Cells	Stem Cell Exhaustion	A 63-year-old man received high-dose cyclophosphamide for peripheral blood stem-cell (PBSC) harvest.	11279645
Pneumonitis, CTCAE	Stem Cell Exhaustion	Radiation-associated pneumonitis following autologous stem cell transplantation: predictive factors, disease characteristics and treatment outcomes.	11281387
Multiple Myeloma	Stem Cell Exhaustion	High-dose therapy followed by autologous stem cell transplantation (ASCT) prolongs survival in patients with multiple myeloma and is relatively safe with treatment-related mortality rates of only 1-5%.	11281387
Lupus Erythematosus, Encephalitis, St. Louis	Stem Cell Exhaustion	Graft failure in a patient with systemic lupus erythematosus (SLE) treated with high-dose immunosuppression and autologous stem cell rescue.	11281396
Lupus Nephritis	Stem Cell Exhaustion	A 32-year-old female with WHO grade IV, dialysis dependent, lupus nephritis was treated with high-dose immunosuppression and autologous stem cell rescue.	11281396
Stem Cell Factor, Tumor necrosis	Stem Cell Exhaustion	Bone marrow MPCs constitutively express interleukin (IL)-1beta, IL-6, granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage (GM)-CSF, stem cell factor (SCF), and tumor necrosis factor (TNF)-alpha.	11283920
Multiple Myeloma	Stem Cell Exhaustion	In the current study, the authors examined bone marrow mesenchymal progenitor cell (MPC) cultures derived from eight multiple myeloma patients (mean age, 58 years) and nine normal donors (mean age, 61 years), with emphasis on cell surface antigens, cytokine, and growth factor expression.	11283920
Peripheral Blood Stem Cells, Hematologic Neoplasms, Neoplasms	Stem Cell Exhaustion	We studied intracellular cytokines in monocytes by flow cytometry from 28 patients with hematologic malignancies and solid tumors to analyze the role of monokines in the hematologic recovery phase for peripheral blood stem cell harvest.	11293819
Hematologic Neoplasms, Neoplasms	Stem Cell Exhaustion	Intracellular cytokine profile of CD14 positive cells in patients with hematologic malignancies and solid tumors during hematologic recovery phase after intensive chemotherapy designed to mobilize peripheral blood stem cells.	11293819
Pathology, Malignant neoplasm of lung	Stem Cell Exhaustion	Lung cancer is a complex collection of diseases that is thought to begin with single mutated progenitor cells and culminates in any of several clinically described pathologies.	11294986
Central Neurocytoma	Stem Cell Exhaustion	These results indicated that the histogenesis of central neurocytomas begins with the subependymal stem cells, which have the potential to differentiate into cholinergic or GABA neurons.	11295115
Secondary Graft Failure After Hematopoietic Cell Transplantation	Stem Cell Exhaustion	Secondary failure of platelet recovery after hematopoietic stem cell transplantation.	11302549
Graft-vs-Host Disease, Liver Dysfunction, Infection	Stem Cell Exhaustion	By multivariable analysis, the following were factors significantly associated with SFPR after allogeneic HSCT: a transplant from an unrelated donor; a graft-versus-host disease (GVHD) prophylaxis other than methotrexate and cyclosporine; development of grade 2 through 4 acute GVHD; impaired renal or liver function; conditioning with the combination of busulfan, cyclophosphamide, and total body irradiation; stem cell dose; and infections.	11302549
Cytomegalovirus Infections	Stem Cell Exhaustion	Cytomegalovirus infection after engraftment and source of stem cells were the only significant risk factors after autologous HSCT.	11302549
Decreased platelet count	Stem Cell Exhaustion	To clarify the mechanism by which the cepharanthin is beneficial to ITP, we examined the effects of cepharanthin on thrombocytopenia in (NZW x BXSB) F1 (W/B F1) mice and on the formation of colony forming unit of megakaryocyte (CFU-MK) derived from human CD34-positive progenitor cells.	11304417
Prostate carcinoma	Stem Cell Exhaustion	Alternative pathways to prostate carcinoma activate prostate stem cell antigen expression.	11309275
Malignant neoplasm of prostate	Stem Cell Exhaustion	Prostate Stem Cell Antigen (PSCA) is a glycosylphosphatidylinositol-anchored cell surface protein that is expressed in normal human prostate and overexpressed in human prostate cancers.	11309275
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Standard allogeneic stem cell transplant (allo-SCT) regimens have been associated with a high transplant-related mortality (TRM) in multiple myeloma (MM).	11313244
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation for clinically aggressive non-Hodgkin's lymphoma: the role of preparative regimens.	11313670
Multiple Myeloma	Stem Cell Exhaustion	Alpha-interferon maintenance treatment is associated with improved survival after high-dose treatment and autologous stem cell transplantation in patients with multiple myeloma: a retrospective registry study from the European Group for Blood and Marrow Transplantation (EBMT).	11313685
Multiple Myeloma	Stem Cell Exhaustion	The purpose of this study was to evaluate the effect of alpha-IFN maintenance treatment after autologous stem cell transplantation (ASCT) for multiple myeloma in a retrospective registry analysis.	11313685
Lymphoma, Neoplasms, Multiple Myeloma	Stem Cell Exhaustion	Infectious complications after high-dose chemotherapy and autologous stem cell transplantation: comparison between patients with lymphoma or multiple myeloma and patients with solid tumors.	11313687
Neoplasms, Lymphoma, Multiple Myeloma, Acute leukemia	Stem Cell Exhaustion	From November 1994 to May 1998, 117 patients (66 with solid tumor, 36 with lymphoma, 14 with multiple myeloma, one with acute leukemia) underwent 178 cycles of high-dose chemotherapy and autologous stem cell transplantation (ASCT) at our institution.	11313687
Varicella Zoster Virus Infection	Stem Cell Exhaustion	A predictive model of varicella-zoster virus infection after autologous peripheral blood progenitor cell transplantation.	11317241
Communicable Diseases	Stem Cell Exhaustion	The frequency of, characteristics of, and risk factors for this infection were studied in 164 patients undergoing autologous peripheral blood progenitor cell transplantation (PBPCT).	11317241
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Efficacy of high-dose therapy and autologous hematopoietic stem cell transplantation for non-Hodgkin's lymphoma in adults 60 years of age and older.	11319588
Aggressive Non-Hodgkin Lymphoma, Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	High-dose therapy (HDT) with autologous stem cell transplantation (ASCT) is the optimal treatment for patients with relapsed aggressive non-Hodgkin's lymphoma (NHL).	11319588
Retinoblastoma	Stem Cell Exhaustion	Recurrent disseminated retinoblastoma in a 7-year-old girl treated successfully by high-dose chemotherapy and CD34-selected autologous peripheral blood stem cell transplantation.	11319597
Multiple Myeloma	Stem Cell Exhaustion	Expression of a free gamma heavy chain in serum following autologous stem cell transplantation for IgG kappa multiple myeloma.	11319600
Neoplasms	Stem Cell Exhaustion	The presence of both medullary and papillary components in the thyroid with lymph node metastases is rare and may suggest that the tumor had arisen from a common stem cell.	11321340
Malignant neoplasm of lung	Stem Cell Exhaustion	The enzyme activity in peripheral mononuclear cells reflected that seen in bronchial epithelial cells, one progenitor cell for lung cancer, supporting the use of peripheral mononuclear cells for larger population-based studies of DNA-PK activity.	11323390
5q-syndrome, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	A pluripotent progenitor cell was demonstrated to be involved in myelodysplastic syndromes (MDS) with normal karyotype or with numerical chromosome aberrations, but the pattern of lineage involvement by the 5q31 deletion in the 5q- syndrome is unknown.	11325642
Renal Cell Carcinoma	Stem Cell Exhaustion	The patient was then entered in our phase-II-study for relapsing germ cell carcinomas using a high-dose chemotherapy regime (paclitaxel 175 mg/m2, ifosfamide 9.000 mg/m2, carboplatin 900 mg/m2, etoposide 900 mg/m2) with subsequent retransfusion of collected stem cells.	11326684
Malignant neoplasm of ovary, Neoplasms	Stem Cell Exhaustion	To detect tumor cell contamination of peripheral blood stem cell (PBSC) and the presence of tumor cells in peripheral circulating blood in patients with primary advanced ovarian cancer.	11326940
Malignant neoplasm of ovary	Stem Cell Exhaustion	14 blood specimens were examined (6 stem cell blood specimens, 8 primary advanced ovarian cancer blood spcimens).	11326940
Rheumatoid Arthritis	Stem Cell Exhaustion	High dose chemotherapy followed by autologous peripheral blood stem cell transplantation or conventional pharmacological treatment for refractory rheumatoid arthritis?	11327241
Rheumatoid Arthritis	Stem Cell Exhaustion	To evaluate the effect of high dose chemotherapy (HDC) followed by autologous hematopoietic stem cell transplantation (ASCT) in comparison to conventional pharmacological therapy in the treatment of patients with refractory, progressively erosive rheumatoid arthritis (RA).	11327241
Purpura, Thrombotic Thrombocytopenic	Stem Cell Exhaustion	In this study, we retrospectively analysed the clinical features, risk factors and outcome of 22 patients with thrombotic thrombocytopenic purpura (TTP) occurring after allogeneic stem cell transplantation.	11328282
leukemia	Stem Cell Exhaustion	All but two of these patients received stem cells from unrelated donors (UDs), two-thirds were female, three-quarters were adults and leukaemia was the major reason for transplant.	11328282
Kidney Diseases	Stem Cell Exhaustion	Effect of dose-intensive intravenous melphalan and autologous blood stem-cell transplantation on al amyloidosis-associated renal disease.	11329232
Dysplasia, Amyloidosis	Stem Cell Exhaustion	Dose-intensive intravenous melphalan with autologous blood stem-cell transplantation induces remission of the plasma cell dyscrasia in a substantial proportion of patients with AL amyloidosis.	11329232
Kidney Diseases	Stem Cell Exhaustion	To determine the effect of dose-intensive intravenous melphalan and autologous blood stem-cell transplantation on AL amyloidosis-associated renal disease.	11329232
Amyloidosis	Stem Cell Exhaustion	65 patients with AL amyloidosis and urinary protein excretion greater than 1 g/24 h who received dose-intensive intravenous melphalan and autologous blood stem-cell transplantation between 1 July 1994 and 30 June 1998.	11329232
Kidney Diseases, Nephrotic Syndrome	Stem Cell Exhaustion	Dose-intensive intravenous melphalan with autologous blood stem-cell transplantation improves the nephrotic syndrome in patients with AL amyloidosis-associated renal disease.	11329232
Chronic graft-versus-host disease, Special Handling Code - Dry	Stem Cell Exhaustion	We present two cases of severe dry eye in patients with chronic graft-versus-host disease (CGVHD) after hematopoietic stem cell transplantation (SCT) who were successfully treated by the systemic administration of FK506 and corticosteroids.	11333336
CNS disorder, Communicable Diseases	Stem Cell Exhaustion	Patients with inadequate organ or bone marrow reserve, HIV or other serious infection, central nervous system disease, or prior stem cell or bone marrow transplantation were ineligible.	11342309
HODGKINS AND NON-HODGKINS LYMPHOMA	Stem Cell Exhaustion	Forty-four consecutive Hodgkin's and non-Hodgkin's lymphoma patients who underwent autologous peripheral blood stem cell (PBSC) transplant treatment between June 1996 and June 1998 were included in this study.	11342334
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	In the present study, we have determined the progenitor cell content in 10 patients with diffuse large-cell lymphoma (DLCL) and characterized the proliferation of these cells in long-term marrow cultures.	11342345
Lymphoma	Stem Cell Exhaustion	As compared to normal subjects, lymphoma patients showed a 35% reduction in progenitor cell numbers, including myeloid, erythroid and multipotent progenitors.	11342345
Lymphoma	Stem Cell Exhaustion	The two groups were not significantly different with respect to source of stem cells, gender, stage at presentation, incidence of prior bone marrow involvement, sensitivity to salvage therapy, or histologic grade of lymphoma.	11342361
Amyloidosis	Stem Cell Exhaustion	Autologous peripheral blood stem cell transplantation following heart transplantation for primary systemic amyloidosis.	11342379
Cardiotoxicity, Haiti	Stem Cell Exhaustion	To avoid cardiac toxicity of chemotherapy, the patient received first a heart transplantation (HT), followed six months later by melphalan 200 mg/m(2) and autologous peripheral blood stem cell support (PBSCT).	11342379
RAPH1 gene	Stem Cell Exhaustion	On the other hand, EBV-DNA was undetectable (<200 copies/mL) in the series of all 58 samples from 10 patients who did not develop LPD after hematopoietic stem cell transplantation.	11345197
Neutropenia, Cyclic neutropenia, Disease	Stem Cell Exhaustion	We believe the immune mechanism of recurrent neutropenia in this patient differs from that in other patients with cyclic neutropenia reported with stem cell disorders.	11345201
Palmar-plantar erythrodysesthesia syndrome, Childhood Breast Carcinoma	Stem Cell Exhaustion	With PBPC mobilization in patients with breast cancer used as a model for chemotherapy-induced PBPC recruitment, the kinetics of progenitor cells mobilized either with cyclophosphamide (CY) or epirubicin/paclitaxel (EPI-TAX) followed by the administration of G-CSF was compared.	11346706
Arthralgia, CTCAE 5, Fever, Nausea, Dehydration, Have Been Vomiting	Stem Cell Exhaustion	Three days after the collection of peripheral stem cell, the patient had fever, nausea, vomiting, liquid stools, shoulder and knee arthralgia and dehydration.	11347514
Stem Cell Factor, Leukemia, Myelocytic, Acute, BCR gene	Stem Cell Exhaustion	Receptors for G-CSF, stem cell factor (SCF), IL-3, IL-6 and IL-7 were detected on CD34+ cells in AML and B-lineage ALL with monoclonal antibodies and flow cytometry.	11350486
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	These findings suggest that a relative increase in the number of PNH granulocytes is a common feature of AA at diagnosis, and that it may represent the presence of immunologic pressure to normal haematopoietic stem cells as a cause of AA.	11350489
Chronic graft-versus-host disease	Stem Cell Exhaustion	Risk factors for chronic graft-versus-host disease after allogeneic stem cell transplantation in children.	11360113
Graft-vs-Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	We analyzed the incidence and risk factors for chronic graft-versus-host disease (GVHD) in 265 children undergoing allogeneic stem cell transplantation (SCT) who survived longer than 3 months post SCT.	11360113
Refractory anemia with ringed sideroblasts	Stem Cell Exhaustion	This study suggests that G-CSF may reduce the pathologically increased caspase activity and concomitant apoptotic changes, and promote erythroid growth and differentiation of stem cells from RARS patients.	11368434
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Forty-nine consecutive patients (median age 49, range 21-70) with acute myelogenous leukemia in first remission were enrolled on a study of high-dose cytarabine/mitoxantrone consolidation chemotherapy with post-recovery IL-2 used as a method of in vivo purging for the purpose of autologous peripheral blood progenitor cell transplantation.	11368436
Cessation of life, Toxic effect	Stem Cell Exhaustion	Toxicity of autologous peripheral blood progenitor cell transplant included treatment-related death in three patients and serious organ toxicity in 12.	11368436
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Transplantation of IL-2-mobilized autologous peripheral blood progenitor cells for adults with acute myelogenous leukemia in first remission.	11368436
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In order to improve leukemia-free survival we evaluated the feasibility and efficacy of autologous transplantation of interleukin-2 (IL-2)-mobilized peripheral blood progenitor cells for adult patients with acute myelogenous leukemia in first remission.	11368436
Toxic effect, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Our results demonstrate that autologous transplantation of IL-2-mobilized peripheral blood progenitor cells is feasible in an unselected population of adult patients with acute myelogenous leukemia in first remission with minimal toxicity but no clear evidence of benefit in leukemia-free survival.	11368436
Neoplasms	Stem Cell Exhaustion	Gradually local tissue fields, which normally restrict stem cell proliferation, become disorganized, leading to further stem cell proliferation, genetic damage, and eventual neoplasia.	11370160
Neoplasms	Stem Cell Exhaustion	Perspectives on brain tumor formation involving macrophages, glia, and neural stem cells.	11370160
Brain Neoplasms	Stem Cell Exhaustion	This hypothesis integrates the general mechanisms by which neural stem cells, glia, and macrophages orchestrate the initiation and progression of brain cancer.	11370160
Pancytopenia	Stem Cell Exhaustion	Although pancytopenia after HDT with stem cell support is of relatively short duration, complications may be severe and life-threatening.	11370600
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Second allogeneic peripheral blood stem cell transplantation with fludarabine-based low-intensity conditioning regimen for relapsed myelodysplastic syndrome after allogeneic bone marrow transplantation.	11372748
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We describe the case of a 51-year-old patient with relapsed myelodysplastic syndrome after allogeneic bone marrow transplantation (BMT), who underwent allogeneic peripheral blood stem cell transplantation (PBSCT) after conditioning with a novel regimen consisting of fludarabine, busulfan, and antithymocyte globulin.	11372748
Lymphoma, Secondary Acute Myeloid Leukemia	Stem Cell Exhaustion	Secondary chronic myelogenous leukemia after autologous peripheral blood stem cell transplantation for lymphoma.	11372749
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We report this case because secondary chronic myelogenous leukemia after stem cell transplantation is rare.	11372749
Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0, Glycosylphosphatidylinositols	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired, clonal hematopoietic stem cell disorder in which PIG-A, gene essential for the biosynthesis of the glycosyl-phosphatidyl-inositol (GPI) anchor, is somatically mutated.	11372757
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	All of the findings suggest that in the condition of deficient hematopoiesis, the PNH clone arising from the mutated hematopoietic stem cell expands and maintains a substantial proportion of the patient's hematopoiesis.	11372757
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	In this study, CD34+ cells--committed progenitors (colony-forming cells) representing immature hematopoietic stem cells--and reticulocytes representing the differentiated erythroid cells were quantitated in peripheral blood of patients with PNH.	11372757
Venous Thrombosis, Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0, Anemia, Hemolytic	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematopoietic stem cell disorder that manifests as hemolytic anemia, venous thrombosis, and deficient hematopoiesis.	11376878
Organ Dysfunction Scores	Stem Cell Exhaustion	Several studies supported the use of nonmyeloablative stem cell transplantation (NST) for patients of advanced age or with organ dysfunction.	11376878
Polycythemia Vera	Stem Cell Exhaustion	Polycythemia vera is a clonal stem cell disorder characterized by hyperproliferation of the erythroid, myeloid, and megakaryocytic lineages.	11378264
Mastocytosis	Stem Cell Exhaustion	The proto-oncogene C-KIT encodes a tyrosine kinase receptor that is expressed on mast cells and haematopoietic stem cells and can show somatic mutations in patients with mastocytosis.	11380399
Lung Diseases, Fungal	Stem Cell Exhaustion	We conclude that pulmonary fungal infections are not a contraindication for allogeneic stem cell transplantation, if non-myeloablative conditioning regimens are used in combination with granulocyte transfusions, intravenous amphotericin B and G-CSF.	11380415
Aplastic Anemia	Stem Cell Exhaustion	Aplastic anaemia (AA) is a syndrome of haemopoietic failure involving increased apoptosis in stem cells.	11380462
Neoplasms	Stem Cell Exhaustion	Through extensive computer modeling, we demonstrate that there is sufficient opportunity for a tumor progenitor cell to achieve homoplasmy through unbiased mtDNA replication and sorting during cell division.	11381261
Neoplasms	Stem Cell Exhaustion	We consider another possibility-that the observed homoplasmy arose entirely by chance in tumor progenitor cells, without any physiological advantage or tumorigenic requirement.	11381261
Neoplasms	Stem Cell Exhaustion	Based on the available data on mitochondrial mutant fractions and cell division kinetics, we show that the predicted frequency of homoplasmy in tumor progenitor cells in the absence of selection is similar to the reported frequency of homoplasmic mutations in tumors.	11381261
Precursor cell lymphoblastic lymphoma, Lymphoma	Stem Cell Exhaustion	High-dose therapy and autologous stem-cell transplantation versus conventional-dose consolidation/maintenance therapy as postremission therapy for adult patients with lymphoblastic lymphoma: results of a randomized trial of the European Group for Blood and Marrow Transplantation and the United Kingdom Lymphoma Group.	11387366
Precursor cell lymphoblastic lymphoma	Stem Cell Exhaustion	To determine whether a combination of high-dose therapy and autologous stem-cell transplantation (ASCT) is superior to conventional-dose consolidation and maintenance chemotherapy as postremission therapy in adults with lymphoblastic lymphoma.	11387366
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Hoechst 33342 efflux identifies a subpopulation of cytogenetically normal CD34(+)CD38(-) progenitor cells from patients with acute myeloid leukemia.	11389030
Breast Carcinoma, Toxic effect	Stem Cell Exhaustion	Feasibility and low toxicity of early radiotherapy after high-dose chemotherapy and autologous stem cell transplantation for patients with high-risk stage II-III and locally advanced breast carcinoma.	11391576
Breast Carcinoma, Toxic effect, Specialty Type - cancer, AJCC tumor staging	Stem Cell Exhaustion	This prospective trial examined the feasibility, toxicity, and effectiveness of early locoregional radiotherapy after high-dose chemotherapy and autologous stem cell transplantation in patients with high-risk American Joint Committee on Cancer (AJCC) Stage II-III and locally advanced breast carcinoma.	11391576
Osteoporosis	Stem Cell Exhaustion	Number and proliferative capacity of osteogenic stem cells are maintained during aging and in patients with osteoporosis.	11393789
Autoimmune Diseases	Stem Cell Exhaustion	Fetal microchimerism, the engraftment of fetal progenitor cells into maternal tissues, has been implicated in the etiology of autoimmune diseases.	11397845
Histiocytic Disorders, Malignant	Stem Cell Exhaustion	Thirdly, plasma levels of GM-CSF and interleukin-3 (IL-3) were examined in patients with malignant disorders who received chemotherapy plus G-CSF for stem cell mobilization.	11399510
Acute leukemia	Stem Cell Exhaustion	The transfusion of ABO-mismatched platelets has been associated with increased morbidity and mortality during induction therapy for acute leukemia and allogeneic progenitor cell transplantation.	11399821
Abnormality of bone mineral density	Stem Cell Exhaustion	The incidence and course of bone density abnormalities following hematopoietic stem cell transplantation are poorly understood and complicated by the impact of multiple factors.	11400947
Bone Demineralization, Pathologic	Stem Cell Exhaustion	Prevention of bone demineralization appears warranted after stem cell transplantation.	11400947
Childhood Breast Carcinoma	Stem Cell Exhaustion	Inhaled steroids as prophylaxis for delayed pulmonary toxicity syndrome in breast cancer patients undergoing high-dose chemotherapy and autologous stem cell transplantation.	11400949
Pulmonary function tests, Childhood Breast Carcinoma	Stem Cell Exhaustion	To evaluate the efficacy of inhaled fluticasone propionate (Flovent) as prophylaxis against delayed pulmonary toxicity syndrome (DPTS) and decline in pulmonary function in breast cancer patients undergoing high-dose chemotherapy with the conditioning regimen of cyclophosphamide, cisplatin, and carmustine (CPB) followed by autologous stem cell transplantation (ASCT).	11400949
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome, Impaired T cell function	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is an acquired, irreversible disorder of ineffective hematopoiesis, characterized by stem cell dysfunction as a consequence of DNA damage manifested in part by karyotype anomalies.	11401093
Acute myocardial infarction	Stem Cell Exhaustion	Mobilization of endothelial progenitor cells in patients with acute myocardial infarction.	11401930
Hematological Disease, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Myelodysplastic syndromes are clonal hematologic disorders, expanded from myeloid stem cells.	11402513
Venoocclusive disease, Hepatotoxicity, Respiratory Distress Syndrome, Newborn, anaphylaxis, Respiratory Distress Syndrome, Adult	Stem Cell Exhaustion	Postmarketing reports of fatal anaphylaxis, adult respiratory distress syndrome (ARDS), and hepatotoxicity, especially venoocclusive disease (VOD) in patients treated with gemtuzumab ozogamicin, with and without associated hematopoietic stem cell transplantation (HSCT), have required labeling revisions and the initiation of a registration surveillance program.	11410481
Neutropenia, Toxic effect, Myelosuppression, Decreased platelet count	Stem Cell Exhaustion	In Phase I studies, the major toxicity was myelosuppression, especially neutropenia and thrombocytopenia, resulting from the expression of CD33 on myeloid progenitor cells.	11410481
Hematologic Neoplasms, Agenesis	Stem Cell Exhaustion	We have studied the outcome of 31 patients with hematologic malignancies who underwent an allogeneic hematopoietic stem cell transplant (HSCT) after failing an autologous transplant because of relapse (n=29) or persistent aplasia (n=2).	11418375
Secondary Neoplasm	Stem Cell Exhaustion	In the first case in which the metastasis developed in the T8 corpus, the disease is presently under control after high-dose chemotherapy and autologous blood stem cell transplantation.	11419982
Neoplasms	Stem Cell Exhaustion	These features suggest that the tumor arose from a multipotential stem cell.	11422813
Acute lymphocytic leukemia	Stem Cell Exhaustion	Risk-oriented postremission strategies in adult acute lymphoblastic leukemia: prospective confirmation of anthracycline activity in standard-risk class and role of hematopoietic stem cell transplants in high-risk groups.	11424004
BCR gene	Stem Cell Exhaustion	High-risk (HR) patients were eligible to the following three options: allogeneic hematopoietic stem cell transplantation (HSCT) from related family donor; short sequence with high-dose cyclophosphamide-cytarabine-methotrexate followed by melphalan/total body irradiation with autologous HSCT; or T(lin) ALL chemotherapy regimen inclusive of high-dose cytarabine and methotrexate.	11424004
Neoplasm Metastasis, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Secondary malignancies, particularly myelodysplasia (MDS), are serious events following high dose therapy with autologous stem cell support.	11426523
Lymphoma, Non-Hodgkin, Familial, Hodgkin Disease, HD Term Type, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Three hundred patients with Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL) were treated with cyclophosphamide, carmustine and etoposide and autologous stem cell support from 1986 through 1994.	11426523
Hodgkin Disease, Fusariosis	Stem Cell Exhaustion	Systemic fusariosis after a preparative regimen including thiotepa, VP-16 and busulfan used for blood stem cell transplantation in Hodgkin's disease.	11426570
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Relapse of chronic myelogenous leukemia 12 years after allogeneic marrow transplantation: successful second transplantation with allogeneic peripheral blood progenitor cells.	11426624
Guillain-Barre Syndrome, Toxoplasmosis, Cerebral	Stem Cell Exhaustion	Cerebral toxoplasmosis and Guillain-Barre syndrome after allogeneic peripheral stem cell transplantation.	11429026
Guillain-Barre Syndrome, Toxoplasmosis, Cerebral, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We report an unusual case of cerebral toxoplasmosis associated with Guillain-Barre syndrome (GBS) in a 25-year-old patient diagnosed with chronic myelogenous leukaemia (CML), who underwent a mismatched allogeneic peripheral stem cell transplantation (PSCT).	11429026
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Identification of myelodysplastic syndrome-specific genes by DNA microarray analysis with purified hematopoietic stem cell fraction.	11435312
PAFAH1B1 wt Allele, leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Toward this goal, AC133 surface marker-positive hematopoietic stem cell (HSC)-like fractions have been collected from a variety of leukemias in a large-scale and long-term genomics project, referred to as "Blast Bank," and transcriptome of these purified blasts from the patients with MDS were then compared with those from AML through the use of oligonucleotide microarrays.	11435312
Graft-vs-Host Disease, Hepatitis	Stem Cell Exhaustion	Hepatic graft-versus-host disease presenting as an acute hepatitis after allogeneic peripheral blood stem cell transplantation.	11436113
Cholestasis	Stem Cell Exhaustion	We describe a 17-year-old Japanese female who had increased aminotransferases without cholestasis on day 23 after allogeneic peripheral blood stem cell transplantation (allo-PBSCT).	11436113
Hepatitis, Acute GVH disease	Stem Cell Exhaustion	These findings indicate that acute hepatic GVHD may present as acute hepatitis and this should be included in the differential diagnosis for patients with increased aminotransferases after allogeneic stem cell transplantation.	11436113
Lymphoma	Stem Cell Exhaustion	Peripheral blood stem cell transplantation in patients over 65 years old with malignant lymphoma--possibility of early completion of chemotherapy and improvement of performance status.	11446668
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	After the initial clinical application of peripheral blood stem cell transplantation (PBSCT) in the latter half of the 1980s, the frequency of PBSCT for non-Hodgkin's lymphoma (NHL) has been gradually increasing.	11446668
Adenoma	Stem Cell Exhaustion	The number of stem cells of the colon (N) and somatic mutation rate of the APC gene in a stem cell in a year (m) can induce age-specific incidence of adenomas.	11450991
Amyloidosis	Stem Cell Exhaustion	Eligibility for hematopoietic stem-cell transplantation for primary systemic amyloidosis is a favorable prognostic factor for survival.	11454882
Multiple Myeloma, Hemopoietic stem cell transplant, Amyloidosis	Stem Cell Exhaustion	Based on the success of hematopoietic stem-cell transplantation (HSCT) for multiple myeloma, HSCT is being used to treat patients with primary systemic amyloidosis (AL).	11454882
Bone marrow hypocellularity, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	In this review, we describe results of recent flow FISH studies in patients with selected hematopoietic stem cell-associated disorders: chronic myelogenous leukemia (CML) and several bone marrow failure syndromes.	11458518
Wiskott-Aldrich Syndrome	Stem Cell Exhaustion	The usefulness of X-linked polymorphic loci as gene markers to track X allele and chimerism in a post-allogeneic peripheral blood stem cell transplant patient with Wiskott-Aldrich syndrome.	11460939
Thrombocytosis, Chronic myeloproliferative disorder, Polycythemia Vera	Stem Cell Exhaustion	Polycythemia vera (PV) and essential thrombocytosis (ET) are clonal chronic myeloproliferative disorders originating from a multipotent stem cell.	11463455
Primary malignant neoplasm	Stem Cell Exhaustion	Stem cell-supported high-dose chemotherapy (HDCT) is currently being evaluated in patients with high-risk primary breast cancer (HRPBC), as defined by extensive axillary lymph node involvement.	11464976
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Low incidence of transplantation-related acute complications in patients with chronic myeloid leukemia undergoing allogeneic stem cell transplantation with a low-dose (550 cGy) total body irradiation conditioning regimen.	11464978
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We investigated, in a phase II trial, the role of a low-dose (550 cGy) high-dose rate (35 cGy/min) single-exposure total body irradiation (TBI) conditioning regimen for allogeneic peripheral blood stem cell (PBSC) transplantation in patients with CML.	11464978
Venoocclusive disease	Stem Cell Exhaustion	Mylotarg (gemtuzumab ozogamicin) therapy is associated with hepatic venoocclusive disease in patients who have not received stem cell transplantation.	11466696
Venoocclusive disease	Stem Cell Exhaustion	Hepatic venoocclusive disease (VOD) has been reported in patients who have undergone stem cell transplantation (SCT) after Mylotarg therapy.	11466696
Parainfluenza Virus Infections	Stem Cell Exhaustion	Parainfluenza virus infections after hematopoietic stem cell transplantation: risk factors, response to antiviral therapy, and effect on transplant outcome.	11468152
Infection	Stem Cell Exhaustion	Parainfluenza virus (PIV) infections may be significant causes of morbidity and mortality in patients undergoing stem cell transplantation, but data regarding their impact on transplant-related mortality is limited.	11468152
Childhood Non-Hodgkin Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Early lymphocyte recovery predicts superior survival after autologous hematopoietic stem cell transplantation in multiple myeloma or non-Hodgkin lymphoma.	11468153
Lymphoma, Non-Hodgkin, Familial, Morular Metaplasia of the Endometrium, Multiple Myeloma, Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) improves survival in patients with previously untreated multiple myeloma (MM) and relapsed, chemotherapy-sensitive, aggressive non-Hodgkin lymphoma (NHL).	11468153
Primary Myelofibrosis	Stem Cell Exhaustion	Myeloablation and autologous peripheral blood stem cell rescue results in hematologic and clinical responses in patients with myeloid metaplasia with myelofibrosis.	11468154
Secondary malignant neoplasm of liver	Stem Cell Exhaustion	Insulinoma of the pancreas with insular-ductular differentiation in its liver metastasis--indication of a common stem-cell origin of the exocrine and endocrine components.	11469696
Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	As to the histogenesis of the tumor and its metastasis, we discuss the following possibilities: (1) the tumor cells might derive from a common stem cell that matures into two phenotypically different cell lines, resembling the situation in embryogenesis and (2) one tumor cell type originates from the other by transdifferentiation (metaplasia).	11469696
Neoplasms	Stem Cell Exhaustion	We propose that the tumor probably arises from totipotential adult stem cells, which in the right microenvironment differentiate along nonnative cell lineages.	11473468
Autoimmune Diseases	Stem Cell Exhaustion	Will mixed chimerism cure autoimmune diseases after a nonmyeloablative stem cell transplant?	11477365
Multiple Myeloma	Stem Cell Exhaustion	Allogeneic stem cell transplantation reduces disease progression compared to autologous transplantation in patients with multiple myeloma.	11477436
Toxic effect, Multiple Myeloma	Stem Cell Exhaustion	A comparison of toxicity following two different doses of cyclophosphamide for mobilization of peripheral blood progenitor cells in 116 multiple myeloma patients.	11477441
Childhood Breast Carcinoma	Stem Cell Exhaustion	HER-2 expression is a prognostic factor in patients with metastatic breast cancer treated with a combination of high-dose cyclophosphamide, mitoxantrone, paclitaxel and autologous blood stem cell support.	11477443
Childhood Breast Carcinoma	Stem Cell Exhaustion	In this study, we evaluated the clinical significance of high and low levels of HER-2 in the plasma of 46 patients with metastatic breast cancer enrolled in a clinical trial of high-dose chemotherapy (HDCT) using cyclophosphamide, mitoxantrone, and paclitaxel with autologous stem cell transplantation (ASCT).	11477443
Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	We report a case of a 5-year-old girl with EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH) who underwent cord blood (CB) stem cell transplantation (CBSCT) from an unrelated donor.	11477448
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 57-year-old female with recurrent AML underwent a T cell-depleted (TCD) bone marrow (BM) plus TCD and CD34-selected peripheral blood stem cell (PBSC) transplant.	11477449
Neoplasms	Stem Cell Exhaustion	All tumors arose from the same progenitor cell.	11477581
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	Infusional DICE is an easily administered and well tolerated programme with significant activity in refractory or relapsed NHL and may be useful as a tumour-reductive therapy prior to high-dose chemotherapy and autologous stem cell transplantation.	11486401
Multiple Myeloma	Stem Cell Exhaustion	Between 8/85 and 6/98, 144 newly diagnosed myeloma patients with a median age of 53 years (range, 31-72) received infusional chemotherapy with vincristine, doxorubicin and methylprednisolone, with/without cyclophosphamide or verapamil, followed by HDM 200 mg/m(2)and stem cell rescue.	11487259
Hodgkin Disease, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	The pattern of emergence of multipotential (CFU-A) and committed (CFU-GM and BFU-E) progenitor cells in peripheral blood has been examined in patients with Hodgkin's disease and non-Hodgkin's lymphoma.	11488851
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	platelet-secreted) PDGF and PF-4 can function as regulators of leukemic hematopoiesis and possibly also modulate the function of residual AML cells in peripheral blood stem cell grafts.	11488935
leukemia	Stem Cell Exhaustion	AC133 is a novel 5-transmembrane antigen present on a CD34((bright)) subset of human hematopoietic stem cells (HSCs) and it is also expressed on the subset of CD34 positive (CD34(+)) leukemias.	11489469
Hematologic Neoplasms	Stem Cell Exhaustion	A fludarabine-based "nonmyeloablative" preparative regimen was investigated in 42 patients with hematological malignancies receiving hematopoietic stem cell grafts from unrelated volunteer donors.	11489799
leukemia	Stem Cell Exhaustion	In this study, a quantitative assay for TRECs was used to measure T-cell neogenesis in adult patients with leukemia who received myeloablative therapy followed by transplantation of allogeneic hematopoietic stem cells.	11493459
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemia.	11493466
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The hematopoietic stem cell underlying acute myeloid leukemia (AML) is controversial.	11493466
Toxic effect, Neoplasms	Stem Cell Exhaustion	Because of the low hematological toxicity of the VAD regimen, this combination is frequently chosen for tumor reduction prior to high-dose therapy and blood stem cell transplantation.	11497393
Osteopetrosis	Stem Cell Exhaustion	A 16-month-old girl diagnosed with osteopetrosis underwent an unrelated, partially matched (with major mismatch at A locus) cord blood stem cell transplant.	11498750
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	MK antigen positive AML might derived from malignant transformation of hemotopoietic stem cell at earlier stage and the detection of MK expression was of values in predicting treatment effect and prognosis for adult AML.	11498838
Tissue damage	Stem Cell Exhaustion	The presence of these male cells may also be a result of disease, possibly through the migration of terminally differentiated and/or progenitor cells to areas of tissue damage.	11508438
Multiple Myeloma	Stem Cell Exhaustion	Dexamethasone, paclitaxel, etoposide, cyclophosphamide (d-TEC) and G-CSF for stem cell mobilisation in multiple myeloma.	11509931
Multiple Myeloma	Stem Cell Exhaustion	Forty-one patients with multiple myeloma were treated with a novel stem cell mobilisation regimen.	11509931
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Blood stem cell collections from 26 non-Hodgkin's lymphoma (NHL) patients harvested during steady-state (non-mobilized) and from 35 NHL patients harvested after cytokine administration (mobilized) were studied.	11509940
Lymphoma	Stem Cell Exhaustion	Lymphoma contamination was positively associated with the number of progenitor cells collected (P = 0.047).	11509940
Histogenic Process, Neoplasms	Stem Cell Exhaustion	Although the histogenesis remains uncertain, advances in immunohistochemistry and electron microscopy suggest the origin of this tumor from a multipotential stem cell precursor.	11510933
Neoplasms	Stem Cell Exhaustion	This appearance suggested that this brain tumor might originate from a common multipotential stem cell.	11517975
MYELODYSPLASTIC SYNDROME, Decreased platelet count, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	BM specimen obtained for thrombocytopenia showed myelodysplasia similar to myelodysplastic syndrome, suggesting that HIV may have an influence on hematopoietic progenitor cells.	11518128
Hepatoblastoma	Stem Cell Exhaustion	Teratoid hepatoblastoma: multidirectional differentiation of stem cell of the liver.	11519086
Hepatoblastoma, Neoplasms, Teratoma	Stem Cell Exhaustion	These teratoid features of hepatoblastoma are considered to be a multidirectional differentiation of the small epithelial cells or stem cells of the tumor.	11519086
Rheumatoid Arthritis, Degenerative polyarthritis, Stem Cell Factor, Tumor necrosis	Stem Cell Exhaustion	CD34(+) cells from the bone marrow of 22 RA patients differentiated into cells with fibroblast-like morphology, which expressed prolyl 4-hydroxylase, in the presence of stem cell factor (SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and tumor necrosis factor alpha (TNF-alpha), much more effectively than CD34(+) cells from bone marrow of 15 control subjects (10 patients with osteoarthritis and 5 healthy individuals).	11527991
Rheumatoid Arthritis	Stem Cell Exhaustion	Induction of fibroblast-like cells from CD34(+) progenitor cells of the bone marrow in rheumatoid arthritis.	11527991
Rheumatoid Arthritis	Stem Cell Exhaustion	These results indicate that bone marrow CD34(+) cells from patients with RA have abnormal capacities to respond to TNF-alpha and to differentiate into fibroblast-like cells producing MMP-1, suggesting that bone marrow CD34(+) progenitor cells might generate type B synoviocytes and thus could play an important role in the pathogenesis of RA.	11527991
Lymphoma	Stem Cell Exhaustion	Cytoreduction and stem cell mobilization with a regimen of paclitaxel, etoposide and cyclophosphamide followed by autologous transplantation using a preparative regimen of busulfan, etoposide and cyclophosphamide for patients with advanced lymphoma.	11528096
Hodgkin Disease, Lymphoma	Stem Cell Exhaustion	Forty-one patients with advanced Hodgkin's disease or intermediate or high-grade lymphoma, after having received standard salvage chemotherapy, were treated with a nonablative high-dose regimen of paclitaxel, etoposide and cyclophosphamide (D-TEC) to optimally cytoreduce their disease and simultaneously mobilize peripheral blood stem cells.	11528096
DHDDS gene, T-Cell Lymphoma	Stem Cell Exhaustion	Between 1985 and 1999, 103 patients (median age 43 years, range 16-65) from eight Italian centres and one Swiss centre, with refractory (n = 38) or relapsed (n = 65) diffuse large B-cell and T-cell lymphoma, were treated using HDS followed by high-dose regimens with autologous haematopoietic stem cell transplantation.	11529852
Adenovirus Infections	Stem Cell Exhaustion	Lethal adenovirus infection in a patient who had undergone nonmyeloablative stem cell transplantation.	11530814
Communicable Diseases	Stem Cell Exhaustion	We present a case of adenovirus (ADV) infection in a patient who had undergone nonmyeloablative stem cell transplantation (NST).	11530814
Acute GVH disease	Stem Cell Exhaustion	Plasma nitric oxide is associated with the occurrence of moderate to severe acute graft-versus-host disease in haemopoietic stem cell transplant recipients.	11532626
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Nitric oxide (NO) has been implicated as one of the mediators of acute graft-versus-host disease (GVHD) but reports on its measurement during haemopoietic stem cell transplantation (HSCT) in human are scarce.	11532626
Multiple Myeloma	Stem Cell Exhaustion	Purging of autologous peripheral-blood stem cells using CD34 selection does not improve overall or progression-free survival after high-dose chemotherapy for multiple myeloma: results of a multicenter randomized controlled trial.	11533101
Multiple Myeloma	Stem Cell Exhaustion	Although high-dose chemotherapy supported by autologous peripheral-blood progenitor-cell (PBPC) transplantation improves response rates and survival for patients with multiple myeloma, all patients eventually develop progressive disease after transplantation.	11533101
Tyrosine Transaminase Deficiency Disease	Stem Cell Exhaustion	To investigate the outcome of cultivated corneal epithelial transplantation for severe stem cell deficiencies using denuded amniotic membrane (AM) as a carrier.	11535452
Tyrosine Transaminase Deficiency Disease	Stem Cell Exhaustion	All of these eyes had total stem cell deficiencies.	11535452
Tyrosine Transaminase Deficiency Disease	Stem Cell Exhaustion	Cultivated corneal epithelial transplantation using denuded AM as a carrier can be used for severe stem cell deficiencies.	11535452
Bone Marrow Stem Cell Transplantation, Cardiac complication	Stem Cell Exhaustion	Cardiac complications may result from high-dose chemotherapy or irradiation administered during the conditioning phase of bone marrow and blood stem cell transplantation (BMT).	11535997
Gastrointestinal complication	Stem Cell Exhaustion	Gastrointestinal complications following hematopoietic stem cell transplantations (HSCTs) are common, but it is unknown how often gastroenterology consultation (GEC) early post BMT leads to specific changes in patient management.	11535998
Capillary Leak Syndrome	Stem Cell Exhaustion	Life-threatening capillary leak syndrome after G-CSF mobilization and collection of peripheral blood progenitor cells for allogeneic transplantation.	11536001
Graft-vs-Host Disease	Stem Cell Exhaustion	Both genetic and clinical factors predict the development of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.	11544434
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease is the main complication of hematopoietic stem cell transplantation.	11544434
Acute GVH disease	Stem Cell Exhaustion	In this study, we searched for risk factors of acute graft-versus-host disease using multivariate Cox regression analysis in 100 consecutive patients who underwent allogeneic stem cell transplantation from an HLA-identical sibling donor.	11544434
Autoimmune hemolytic anemia	Stem Cell Exhaustion	Autologous peripheral blood stem cell transplantation and anti-B-cell directed immunotherapy for refractory auto-immune haemolytic anaemia.	11548187
Failure	Stem Cell Exhaustion	Due to failure of conventional immunosuppressive therapy, an autologous peripheral blood stem cell transplantation was performed.	11548187
Autoimmune hemolytic anemia	Stem Cell Exhaustion	Our case report suggests that rituximab and autologous peripheral blood stem cell transplantation are important though not curative elements in the treatment of patients with severe auto-immune haemolytic anaemia who are refractory to conventional immunosuppressive therapy.	11548187
Respiratory Distress Syndrome, Newborn	Stem Cell Exhaustion	Peri-engraftment respiratory distress syndrome during autologous hematopoietic stem cell transplantation.	11548849
Selective Estrogen Receptor Down Regulator, Communicable Diseases, Respiratory Distress Syndrome, Newborn, Hypernatremia, Cardiac dysfunction	Stem Cell Exhaustion	From 1987 to 1998, 19 of 416 patients (4.6%) who underwent autologous hematopoietic stem cell transplantation experienced peri-engraftment (within 5 days of neutrophil recovery) respiratory distress syndrome (PERDS) not attributable to infection, fluid overload, or cardiac dysfunction.	11548849
Dermatomyositis, Multiple Myeloma	Stem Cell Exhaustion	Dermatomyositis and sarcoid-like reaction associated with multiple myeloma treated effectively by high-dose chemotherapy and autologous peripheral blood stem cell transplantation.	11551034
Myopathy	Stem Cell Exhaustion	There was, however, a dramatic and sustained response to high-dose chemotherapy and autologous peripheral blood stem cell transplantation which resulted in resolution of the myopathy and partial resolution of the sarcoid-like reaction.	11551034
Hematologic Neoplasms	Stem Cell Exhaustion	This case report highlights the potential of autologous stem cell transplantation as treatment for para-neoplastic disorders associated with haematological malignancies.	11551034
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation in elderly multiple myeloma patients over the age of 70 years.	11552985
Mycosis Fungoides, Neoplasms	Stem Cell Exhaustion	T-cell depletion and autologous stem cell transplantation in the management of tumour stage mycosis fungoides with peripheral blood involvement.	11552988
Mycosis Fungoides, Neoplasms	Stem Cell Exhaustion	Nine patients with tumour stage mycosis fungoides (MF) have been entered into a pilot study of T-cell depletion and autologous stem cell transplantation (SCT).	11552988
Corneal Ulcer, Keratopathy	Stem Cell Exhaustion	The indications for the corneal group were limbal stem cell deficiency, bullous keratopathy, persistent epithelial defect, band keratopathy, prosthesis, corneal ulcer and acute chemical burn.	11560222
Pneumonia, Interstitial	Stem Cell Exhaustion	Although the condition resolved by conservative management alone, the patient developed Klebsiella pneumonia sepsis, interstitial pneumonitis, failed to engraft, and died on day +66 following a second infusion of stem cells mobilized from his father's peripheral blood.	11560758
Kidney Failure, Multiple Myeloma	Stem Cell Exhaustion	Results of autologous stem cell transplant in multiple myeloma patients with renal failure.	11564069
Kidney Failure, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Data are presented on 81 multiple myeloma (MM) patients with renal failure (creatinine > 176.8 micromol/l) at the time of autologous stem cell transplantation (auto-SCT), including 38 patients on dialysis.	11564069
Kidney Failure	Stem Cell Exhaustion	In conclusion, renal failure had no impact on the quality of stem cell collections and did not affect engraftment.	11564069
Hyperpigmentation, Cutaneous Fibrous Histiocytoma	Stem Cell Exhaustion	The mechanism of epidermal hyperpigmentation in dermatofibroma is associated with stem cell factor and hepatocyte growth factor expression.	11564169
Cutaneous Fibrous Histiocytoma	Stem Cell Exhaustion	Reverse transcription polymerase chain reaction analysis of mRNAs encoding stem cell factor and hepatocyte growth factor demonstrated that there is an accentuated expression of stem cell factor and hepatocyte growth factor transcripts in the lesional dermatofibroma dermis compared with the nonlesional dermis, although there is no difference in their expression between the lesional and nonlesional epidermis.	11564169
Neoplasms, Cutaneous Fibrous Histiocytoma	Stem Cell Exhaustion	In parallel, immunohistochemical analysis using antibodies to stem cell factor and hepatocyte growth factor reveal a marked immunostaining in growing fibroblastic tumor cells in the dermatofibroma lesions with no detectable staining in the nonlesional dermis, but there is no difference in their immunostaining between the lesional and nonlesional epidermis.	11564169
Cutaneous Fibrous Histiocytoma	Stem Cell Exhaustion	Interestingly, and consistent with the increased expression of stem cell factor in lesional dermatofibroma dermis, toluidine blue staining in the dermis revealed a 5-fold increase in the number of mast cells, an indication of their longevity or accumulation induced by stem cell factor.	11564169
Neoplasms, Hyperpigmentation, Cutaneous Fibrous Histiocytoma	Stem Cell Exhaustion	These findings suggest an important role of fibroblastic tumor cell-derived stem cell factor in the mechanism involved in the hyperpigmentation of the dermatofibroma epidermis.	11564169
Renal Cell Carcinoma Pathway, Dysesthesia	Stem Cell Exhaustion	A 37-year-old man with a history of metastatic renal cell carcinoma treated with systemic agents, an autologous stem cell transplant, and local palliative radiotherapy with a 2-month history of vague right foot numbness and right leg dysesthesias was found to have an intramedullary lesion at the level of T12.	11564920
Gastrointestinal Hemorrhage, Amyloidosis	Stem Cell Exhaustion	High incidence of gastrointestinal tract bleeding after autologous stem cell transplant for primary systemic amyloidosis.	11571511
Amyloidosis	Stem Cell Exhaustion	Peripheral blood stem cell transplants have been associated with better response rates than conventional chemotherapy in patients with primary systemic amyloidosis.	11571511
Gastrointestinal tract structure, Amyloidosis	Stem Cell Exhaustion	A higher incidence of gastrointestinal (GI) tract bleeding has been observed among amyloidosis patients undergoing peripheral stem cell transplantation.	11571511
Hypopigmentation-immunodeficiency disease	Stem Cell Exhaustion	Griscelli syndrome: report of the first peripheral blood stem cell transplant and the role of mutations in the RAB27A gene as an indication for BMT.	11571516
Hypopigmentation-immunodeficiency disease	Stem Cell Exhaustion	We report the first peripheral blood stem cell transplant (PBSCT) with T cell depletion in a 6-month-old girl with Griscelli syndrome, and a deletion of the RAB27A gene.	11571516
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Thus after intensive induction treatment, high-dose chemotherapy in remission may be practicable using stem-cell rescue and may contribute to a further improvement in the outcome in poor-risk as well as average-risk patients with AML.	11587366
Respiratory Tract Infections	Stem Cell Exhaustion	Respiratory virus infections after stem cell transplantation: a prospective study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation.	11593321
Community-Acquired Infections	Stem Cell Exhaustion	Community-acquired respiratory virus infections are a cause of mortality after stem cell transplantation (SCT).	11593321
Hematologic Neoplasms, Peripheral Stem Cell Transplantation, Neoplasms	Stem Cell Exhaustion	Further high dose chemotherapy with CPM, ADM, CDDP, VP-16 combined with peripheral blood stem cell transplantation led to almost complete disappearance of the tumor and normalization of blood tumor markers (neuron specific enolase and immunosuppressive acidic protein).	11593707
Stage I Mycosis Fungoides AJCC v7	Stem Cell Exhaustion	Autologous peripheral blood stem cell transplantation in tumor-stage mycosis fungoides: predictors of disease-free survival.	11594568
Mycosis Fungoides	Stem Cell Exhaustion	Nine patients with mycosis fungoides (age range 27-67) underwent autologous peripheral blood stem cell transplantation (PBSCT).	11594568
Hematological Disease	Stem Cell Exhaustion	Allogeneic peripheral blood stem cell transplantation (PBSCT) from HLA-identical sibling donors in children with hematological diseases: a single center pilot study.	11607765
Pancytopenia, Waldenstrom Macroglobulinemia	Stem Cell Exhaustion	Successful non-myeloablative allogeneic peripheral blood stem cell transplantation (PBSCT) for Waldenstrom's macroglobulinemia with severe pancytopenia.	11607775
Pancytopenia, Waldenstrom Macroglobulinemia	Stem Cell Exhaustion	We report a 62-year-old male who underwent non-myeloablative allogeneic peripheral blood stem cell transplantation (PBSCT) because of his life-threatening severe pancytopenia due to refractory Waldenstrom's macroglobulinemia.	11607775
Lymphoma, Non-Hodgkin, Ulcerative Colitis	Stem Cell Exhaustion	Ulcerative colitis after autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma.	11607778
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	A 54-year-old woman with peripheral T cell lymphoma in second complete remission (CR) received an autologous peripheral blood stem cell transplant (PBSCT).	11607778
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 39-year-old man with acute myeloid leukemia underwent completely matched related hematopoietic stem cell transplantation.	11668409
Lymphoma, Non-Hodgkin, Childhood Breast Carcinoma	Stem Cell Exhaustion	We examined the optimal time for generating DC and compared DC generated from normal donors for allogeneic blood stem cell transplantation, or patient's with non-Hodgkin's lymphoma or breast cancer undergoing high-dose chemotherapy and autologous stem cell transplantation.	11672508
Malignant Neoplasms	Stem Cell Exhaustion	Application of autologous peripheral blood stem cell transplantation in children with malignant tumor.	11677775
Neoplasms, leukemia	Stem Cell Exhaustion	To investigate if low dose total body irradiation (TBI, 6.0-9.0 Gy) combined with intensified chemotherapy followed by autologous peripheral blood stem cell transplantation results in better survival in children with refractory leukemia or solid tumors.	11677775
Neoplasms, leukemia	Stem Cell Exhaustion	Our preliminary data suggest that myeloablative therapy with low dose TBI (6.0-9.0 Gy) combined with intensified chemotherapy followed by autologous peripheral blood stem cell transplantation might be associated with favorable results in children with refractory leukemia or solid tumors.	11677775
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Epstein-Barr virus(EBV)-associated posttransplant lymphoproliferative disease (PTLD) is a serious complication after allogeneic hematopoietic stem cell transplantation (HSCT).	11694778
Stable chronic Graft vs Host Disease, Disease of mucous membrane, Lichen Planus	Stem Cell Exhaustion	Chronic graft versus host disease (cGVHD) of the oral mucosa, following allogeneic stem cell transplantation, and oral lichen planus (OLP) are both mucosal diseases where the immune system is involved in the pathogenesis.	11696204
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Patients were followed during consolidation chemotherapy with repetitive cycles of high-dose Ara-C and after autologous or allogeneic stem cell transplantation in 2nd CR or refractory AML.	11697647
Acute lymphocytic leukemia	Stem Cell Exhaustion	Early relapse after high-dose chemotherapy rescued by tumor-free autologous peripheral blood stem cells in acute lymphoblastic leukemia: importance of monitoring for WT1-mRNA quantitatively.	11699212
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	In PNH, haematopoietic stem cells that harbour PIGA mutations give rise to blood elements that are unable to synthesize glycosylphosphatidylinositol (GPI) anchors.	11703352
Neoplasms	Stem Cell Exhaustion	These defects are associated with a poor prognosis and are mediated, in part, by an increased number of immune inhibitory CD34(+) progenitor cells in their peripheral blood and tumor.	11704292
Childhood Non-Hodgkin Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	High relapse rates during the first year after autologous stem cell transplantation (ASCT) for multiple myeloma or non-Hodgkin lymphoma are due to the failure of high-dose chemotherapy to eradicate minimal residual disease.	11704790
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Autologous stem-cell transplantation for poor-risk and relapsed intermediate- and high-grade non-Hodgkin's lymphoma.	11707813
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	The primary objective of this study was to evaluate the outcome of patients treated with high-dose chemo-/radiotherapy or high-dose chemotherapy and autologous stem-cell transplant (ASCT) for relapsed, refractory, or poor-risk intermediate-grade (IG) and high-grade (HG) non-Hodgkin's lymphoma (NHL).	11707813
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	CHOP versus CHOP plus ESHAP and high-dose therapy with autologous peripheral blood progenitor cell transplantation for high-intermediate-risk and high-risk aggressive non-Hodgkin's lymphoma.	11707834
Aggressive Non-Hodgkin Lymphoma, Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	The purpose of the study was to compare conventional cyclophosphamide/doxorubicin/vincristine/prednisolone (CHOP) chemotherapy with CHOP (3 courses) plus etoposide/methylprednisolone/high-dose cytarabine/cisplatin (ESHAP), high-dose therapy (HDT), and autologous peripheral blood progenitor cell transplantation (PBPCT) as front-line treatment for poor-prognosis aggressive non-Hodgkin's lymphoma (NHL).	11707834
Lymphoma, Large-Cell, Follicular	Stem Cell Exhaustion	Autologous peripheral blood progenitor cell transplantation for transformed diffuse large-cell lymphoma.	11707835
Lymphoma, Large-Cell, Follicular	Stem Cell Exhaustion	High-dose chemotherapy and autologous peripheral blood progenitor cell (PBPC) transplantation is the treatment of choice for patients with relapsed nontransformed diffuse large-cell lymphoma.	11707835
MYELODYSPLASTIC SYNDROME, Acute leukemia	Stem Cell Exhaustion	Myelodysplastic syndromes (MSD) are a group of clonal disorders of the hemopoietic stem cell, often evolving in acute leukemia.	11710507
Specialty Type - cancer, Carcinogenesis	Stem Cell Exhaustion	Thus, the "stem cell" and "dedifferentiation" hypotheses for cancer origin could complement one another, and dedifferentiation-redifferentiation processes might be decisive for carcinogenesis in the stomach.	11710638
Specialty Type - cancer	Stem Cell Exhaustion	Cancer presumably arises from stem cells, preserved in an undifferentiated status since fetal development, or from a dedifferentiation of mature cells that return into a fetal phenotype with the potential for proliferation and renewal.	11710638
Non-Small Cell Lung Carcinoma, Myeloid Progenitor Cells	Stem Cell Exhaustion	The purpose of this study was to verify the kinetic response of the human marrow myeloid progenitor cells to the short term use of GM-CSF and its impact on the therapeutic activity of this three-drug cisplatinum containing regimen in non small cell lung cancer (NSCLC).	11718213
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	To explore the inhibitory effect of sera from patients with myelodysplastic syndromes (MDS) on the growth of normal hematopoietic progenitor cells.	11721395
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Sera from two MDS patients induced apoptosis of normal hematopoietic progenitor cells.	11721395
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Inhibitors of hematopoietic progenitor cells are present in sera from some MDS patients.	11721395
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	[Successful treatment of AML by HLA-compatible sibling umbilical cord blood stem cell transplantation--the first case report in China].	11721417
Graft-vs-Host Disease, Hematologic Neoplasms	Stem Cell Exhaustion	To apply umbilical cord blood stem cell transplantation (UCBSCT) to the treatment of hematological malignancies, and to observe the persistent hematopoietic reconstitution, graft-versus-host disease (GVHD) and transplantation-related complications.	11721417
PAFAH1B1 wt Allele	Stem Cell Exhaustion	The colonies of hematopoietic progenitor cells were decreased in Evi-1 and MDS1-Evi-1-positive MDS patients as compared with those in Evi-1 and MDS1-Evi-1-negative patients.	11721451
Ki-1+ Anaplastic Large Cell Lymphoma	Stem Cell Exhaustion	Autologous peripheral stem-cell transplantation after intensive chemotherapy in a case of CD30 (Ki-1)-positive anaplastic large-cell lymphoma.	11725830
Peripheral Blood Stem Cells, Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Simultaneous treatment with peripheral blood stem-cell (PBSC) transplantation and intensive chemotherapy was evaluated in a case of non-Hodgkin's lymphoma (NHL) with poor prognosis.	11725830
Hypoxia	Stem Cell Exhaustion	HISTORY, ADMISSION FINDINGS AND DIAGNOSIS: After stem-cell transplantation a 45-year-old woman (case 1) had an attack of general hypoxia requiring resuscitation.	11727162
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Autologous transplantation in acute myeloid leukemia: peripheral blood stem cell harvest after mobilization in steady state by granulocyte colony-stimulating factor alone.	11732869
Neutropenia, Single organ dysfunction	Stem Cell Exhaustion	Reasons for not autografting were inadequate stem cell harvest (ten patients), early relapse (two patients), prolonged neutropenia (one patient), organ failure (two patients), or patient refusal (one patient).	11732869
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In order to determine whether granulocyte colony-stimulating factor (G-CSF) alone initiated during steady state was able to mobilize peripheral blood stem cells (PBSC) in acute myeloid leukemia (AML) and to assess predictive factors for engraftment after autologous PBSC transplantation, we studied 49 successive adult AML patients for whom autologous transplantation was planned between July 1994 and November 1998.	11732869
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We analyzed the prognostic factors for a successful mobilization and peripheral blood stem cell collection in a series of 57 consecutive patients with multiple myeloma (MM); a new scoring system to predict an adequate mobilization in this subset of patients was also constructed.	11732870
Cytomegalovirus	Stem Cell Exhaustion	Cytomegalovirus enteritis after autologous peripheral blood stem cell transplantation.	11732876
Peripheral T-Cell Lymphoma, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	A 61-year-old male with non-Hodgkin's lymphoma (peripheral T-cell lymphoma, unspecified, clinical stage IVb) received autologous peripheral blood stem cell transplantation (PBSCT) during first remission.	11732876
Toxic effect	Stem Cell Exhaustion	Reduced-intensity conditioning (RIC) regimens for allogeneic haematopoietic stem cell transplantation (SCT) have been shown to lead to engraftment of donor stem cells without the severe extra-haematological toxicities of traditional myeloablative transplants.	11736950
Toxic effect	Stem Cell Exhaustion	This study investigated the use of a nonablative conditioning regimen to decrease toxicity and achieve engraftment of an allogeneic blood stem cell transplant, allowing a graft-versus-malignancy effect to occur.	11739162
Toxic effect, Lymphoma, Myelosuppression	Stem Cell Exhaustion	Nonablative chemotherapy with fludarabine/cyclophosphamide followed by allogeneic stem cell transplantation is a promising therapy for indolent lymphoma with minimal toxicity and myelosuppression.	11739162
Lymphoma	Stem Cell Exhaustion	High-dose cyclophosphamide followed by autologous peripheral blood progenitor cell transplantation improves the salvage treatment for persistent or sensitive relapsed malignant lymphoma.	11743614
Hodgkin Disease, Peripheral Stem Cell Transplantation, Neoplasms	Stem Cell Exhaustion	The aim of the present nonrandomized clinical trial was to demonstrate the role of high-dose cyclophosphamide (HDCY) in reducing tumor burden and also to determine the effectiveness of HDCY followed by etoposide (VP-16) and methotrexate (MTX) in Hodgkin's disease plus high-dose therapy with peripheral blood progenitor cell (PBPC) transplantation as salvage treatment.	11743614
Graft-vs-Host Disease, FLT3 protein, human	Stem Cell Exhaustion	This report provides baseline data for studies that will show whether other cytokines such as granulocyte macrophage colony stimulating factor (GM-CSF) and/or Flt-3 Ligand can immunomodulate allotransfusates in vivo to improve the graft-vs.-leukemia (GVL) effect after allogeneic stem cell transplantation, while lowering the incidence and severity of graft-vs.-host disease (GVHD).	11746533
Peripheral Blood Stem Cells, Hodgkin Disease, Lymphoma, Non-Hodgkin, Lymphoma, Non-Hodgkin, Familial, HD Term Type	Stem Cell Exhaustion	Ten patients with non-Hodgkin's lymphoma (NHL) received ifosfamide and vinorelbine, and 17 with Hodgkin's disease (HD) received ifosfamide, vinorelbine and gemcitabine (IGEV regimen), as induction chemotherapy before high-dose chemotherapy (HDT) with peripheral blood stem cell (PBSC) support.	11753545
Neoplasms	Stem Cell Exhaustion	We studied interleukin-6 (IL-6) levels on the day of transplantation in 31 patients undergoing autologous haemopoietic stem cell transplantation (SCT) (either peripheral blood stem cell transplantation (PBSCT) or bone marrow transplantation (BMT)) for neoplastic diseases to determine if there was a relationship between IL-6 level and rate of haemopoietic recovery, length of stay in hospital, and survival.	11753546
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Thirteen AML patients (excluding four relapsed after autologous stem cell transplantation) were grouped into four categories to stratify the probability of achieving complete remission (CR): group 1, first CR duration > or = 2 years and receiving first salvage treatment (S1); group 2, first CR duration 1-2 years and receiving S1; group 3, first CR duration 0-1 years and receiving S1; and group 4, first CR duration 0-1 years and receiving S2, S3, or S4 after failing S1.	11754412
Multiple Myeloma	Stem Cell Exhaustion	Methods for estimation of bone marrow plasma cell involvement in myeloma: predictive value for response and survival in patients undergoing autologous stem cell transplantation.	11754416
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myeloid leukemia (CML) is caused by a BCR-ABL chromosome translocation in a primitive hematopoietic stem cell.	11754648
Ionizing radiation, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The existence of a dead-band is important, because it would imply that low levels of hematopoietic stem cell killing can be permanent; i.e., it would imply that low doses of ionizing radiation can cause permanent reductions in the total number of CML target cells and thus permanent reductions in the subsequent risk of spontaneous CML.	11754648
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Our calculations indicate that, due to dead-band hematopoietic stem cell control, if hematopoietic stem cells are as hypersensitive to killing at low doses as epithelial cells, reductions in the spontaneous CML risk could exceed the low-dose risks of induced CML; i.e., the net lifetime CML risk could have a U-shaped dose-response curve.	11754648
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The number of hematopoietic stem cells in the body is thus a major factor in CML risk.	11754648
Neoplasms	Stem Cell Exhaustion	Tumour regression following stem cell infusion from daughter to microchimeric mother.	11755614
Neoplasms	Stem Cell Exhaustion	The tumour regressed after stem cell infusion and has remained in regression for over 1 year.	11755614
Stevens-Johnson Syndrome	Stem Cell Exhaustion	A 9-year-old patient suffering from Stevens-Johnson syndrome with total keratinization of the ocular surface of both eyes was treated in the left eye by corneal and conjunctival stem cell transplantation.	11755849
Hodgkin Disease, Multiple Myeloma, Myeloid Leukemia, Chronic, Lymphoma, Non-Hodgkin, Familial, HD Term Type, Neoplasms, Morular Metaplasia of the Endometrium, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	CD34+ cell counts in peripheral blood (PB) and corresponding numbers of CD34+ cells and colony-forming units-granulocyte/macrophage (CFU-GM) in 299 leukapheresis products of 209 patients undergoing PB progenitor cell (PBPC) mobilization for autologous transplantation in two different centers were analyzed and compared according to diagnosis: non-Hodgkin lymphoma (NHL, 94 leukaphereses), multiple myeloma (MM, 75), Hodgkin's disease (HD, 37), solid tumors (35), and chronic myeloid leukemia (CML, 32).	11757722
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	Recently, PNH is a stem cell disorder with all hematopoietic lineages affected, which have deficiencies of glycosylphosphtidylinositol-anchored membrane proteins due to the phosphatidylinositol glycan-class A (PIG-A) gene abnormalities.	11769477
Aplastic Anemia	Stem Cell Exhaustion	[Treatment of acute aplastic anemia with allogeneic peripheral blood stem cell transplantation: a case report and literature review].	11769680
Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	After a partial response (PR) was induced by high-dose chemotherapy with peripheral blood stem cell transplantation, she underwent mastectomy with biopsy of the bilateral axillary lymph nodes.	11773264
Adrenal Cortical Adenoma, Carcinoma	Stem Cell Exhaustion	Adrenal adenomas and carcinomas are mostly monoclonal, suggesting that a genetic alteration in a progenitor cell may contribute to their development.	11774288
Neoplasms	Stem Cell Exhaustion	The four cases of the benign tumors might be originated from a common stem cell, such as the so-called amphocrine cell.	11775215
Thrombasthenia	Stem Cell Exhaustion	To investigate whether artificial heterozygous chimeras of platelets can be established by intrauterine transplantation of fetal liver stem cells and evaluate its potential use for the treatment of Glanzmann thrombasthenia.	11780325
Complication Aspects	Stem Cell Exhaustion	On the other hand, liver complications are frequent following allogeneic stem cell transplantation (HSCT).	11781614
Heart failure, Aplastic Anemia	Stem Cell Exhaustion	Successful non-myeloablative stem cell transplantation for a heavily transfused woman with severe aplastic anemia complicated by heart failure.	11781631
Single organ dysfunction	Stem Cell Exhaustion	The clinical course of this patient indicates that this preparative regimen enables SAA patients with severe organ failure to safely undergo allogeneic stem cell transplantation.	11781631
Multiple Myeloma	Stem Cell Exhaustion	DCEP (dexamethasone, cyclophosphamide, etoposide, and cisplatin) is an effective regimen for peripheral blood stem cell collection in multiple myeloma.	11781643
Multiple Myeloma	Stem Cell Exhaustion	In conclusion, DCEP, in addition to its demonstrated anti-tumor activity, is an effective regimen for mobilizing peripheral blood progenitor cells in myeloma patients, with little or no side-effects.	11781643
Childhood Breast Carcinoma	Stem Cell Exhaustion	Prolonged survival associated with early lymphocyte recovery after autologous hematopoietic stem cell transplantation for patients with metastatic breast cancer.	11781647
Lymphoma, Non-Hodgkin, Multiple Myeloma	Stem Cell Exhaustion	Early absolute lymphocyte count (ALC) recovery at day 15 post-autologous stem cell transplantation (ASCT) is a powerful prognostic indicator for survival in multiple myeloma and non-Hodgkin's lymphoma.	11781647
Pregnancy Complications, Infectious, Peripheral Stem Cell Transplantation, Childhood Breast Carcinoma	Stem Cell Exhaustion	Infectious complications in breast cancer patients undergoing peripheral blood stem cell transplantation: a single center retrospective analysis towards outpatient strategy.	11781650
Hepatic Veno-Occlusive Disease	Stem Cell Exhaustion	We describe the first report of hepatic veno-occlusive disease (HVOD) developing after Mylotarg infusion in a patient who underwent hematopoietic stem cell transplantation 8 months earlier.	11781652
Anemia	Stem Cell Exhaustion	The beneficial effect of FZQXT in treating refractory anemia might be reached through promoting the proliferation of erythrocytic hematopoietic stem cells.	11783158
Hodgkin Disease, HD Term Type	Stem Cell Exhaustion	To evaluate prospectively the feasibility and efficacy of early intensive therapy, including intensified cytoreductive chemotherapy (CT) and high-dose CT (HDCT) followed by autologous stem-cell transplantation (ASCT), in patients with advanced Hodgkin's disease (HD) who failed to respond completely or relapsed after initial treatment.	11786576
Ann Arbor Stage I Nasal Type NK/T-Cell Lymphoma	Stem Cell Exhaustion	L-asparaginase induced durable remission of relapsed nasal NK/T-cell lymphoma after autologous peripheral blood stem cell transplantation.	11794702
Lymphoma	Stem Cell Exhaustion	Because her NK/T-cell lymphoma was highly aggressive and chemo-resistant, she underwent autologous peripheral blood stem cell transplantation (PBSCT).	11794702
Histiocytosis haematophagic	Stem Cell Exhaustion	Successful allogeneic stem cell transplantation from an unrelated donor for aggressive Epstein-Barr virus-associated clonal T-cell proliferation with hemophagocytosis.	11794703
Histiocytosis haematophagic	Stem Cell Exhaustion	We present here a case of aggressive Epstein-Barr virus (EBV)-associated clonal T-cell proliferation with hemophagocytosis that was successfully treated by allogeneic stem cell transplantation using an unrelated donor.	11794703
Hemopoietic stem cell transplant	Stem Cell Exhaustion	Active hematopoietic stem cell transplantation center and a university hospital medical ICU.	11796449
MS gene	Stem Cell Exhaustion	Forty-eight chronic lesions obtained at autopsy from 10 patients with multiple sclerosis were examined immunocytochemically for oligodendrocytes and oligodendrocyte progenitor cells.	11796850
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Changes in the T-helper cell 1/T-helper cell 2 balance of peripheral T-helper cells after autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma.	11797111
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	The purpose of this study was to analyze changes in the T-helper cell 1/T-helper cell 2 (Th1/Th2) balance of peripheral T-helper cells after autologous peripheral blood stem cell transplantation (auto-PBSCT) for non-Hodgkin's lymphoma (NHL) and to evaluate the effects of chemotherapy and granulocyte colony-stimulating factor (G-CSF) on the Th1/Th2 balance.	11797111
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	A series of peripheral blood samples from four patients with NHL were collected before peripheral blood stem cell harvest and after auto-PBSCT.	11797111
Up	Stem Cell Exhaustion	Stem-cell factor and vascular endothelial growth factor levels in the skin blister fluid and plasma of patients with SM were not significantly different from those in patients with AD or healthy control subjects.	11799370
Specialty Type - cancer	Stem Cell Exhaustion	A graft-versus-colonic cancer effect of allogeneic stem cell transplantation.	11803361
Hematologic Neoplasms	Stem Cell Exhaustion	Allogeneic stem cell transplantation (ASCT) has proved to have an important immune-mediated anti-tumour effect in patients with haematologic malignancies.	11803361
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GVHD) is a major complication of stem cell transplantation.	11804070
Peripheral Stem Cell Transplantation, Multiple Myeloma	Stem Cell Exhaustion	Comparison of 200 mg/m(2) melphalan and 8 Gy total body irradiation plus 140 mg/m(2) melphalan as conditioning regimens for peripheral blood stem cell transplantation in patients with newly diagnosed multiple myeloma: final analysis of the Intergroupe Francophone du Myelome 9502 randomized trial.	11806971
Multiple Myeloma	Stem Cell Exhaustion	This regimen should be considered as the standard of care before autologous stem cell transplantation in multiple myeloma.	11806971
Rhabdomyolysis	Stem Cell Exhaustion	Rhabdomyolysis is an unusual complication of hematopoietic stem cell transplantation (HSCT).	11807638
Hematological Disease, Tracheobronchial	Stem Cell Exhaustion	Good responses were seen in 60% of those with pulmonary or tracheobronchial IA (n=84), 16% with cerebral IA (n=19), 58% with hematologic disorders (n=67), and 26% of allogeneic stem cell transplant recipients (n=23).	11807679
Cessation of life, Mycoses, Cytomegalovirus Infections	Stem Cell Exhaustion	High risk of death due to bacterial and fungal infection among cytomegalovirus (CMV)-seronegative recipients of stem cell transplants from seropositive donors: evidence for indirect effects of primary CMV infection.	11807708
Aspergillus flavus allergenic extract, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Secondary cutaneous aspergillosis due to Aspergillus flavus in an acute myeloid leukaemia patient following stem cell transplantation.	11809609
Specialty Type - cancer, leukemia	Stem Cell Exhaustion	SDC in four Cancer and Leukemia Group B (CALGB) trials was compared with hematopoietic stem-cell support in patients from the Autologous Blood and Marrow Transplant Registry.	11821456
Anemia, Sickle Cell	Stem Cell Exhaustion	Hematopoietic stem cell transplantation after reduced-intensity conditioning as treatment of sickle cell disease.	11823031
Conjunctival intraepithelial neoplasia, Limbal stem cell deficiency	Stem Cell Exhaustion	Successful treatment with 5-fluorouracil of conjunctival intraepithelial neoplasia refractive to mitomycin-C. To describe the histopathological findings and successful treatment with 5-fluorouracil (5-FU) of a conjunctival intraepithelial neoplasia with limbal stem cell deficiency that was refractive to topical mitomycin-C (MMC).	11825803
Blast Phase	Stem Cell Exhaustion	Subsequently the patient in blast crisis underwent allogeneic stem-cell transplantation.	11826673
Wiskott-Aldrich Syndrome	Stem Cell Exhaustion	Successful allogeneic peripheral blood stem cell transplantation in Wiskott-Aldrich Syndrome Patients: first report in Thailand.	11826914
Familial Hemophagocytic Lymphocytosis	Stem Cell Exhaustion	When there is strong clinical suspicion of FHL, chemotherapy and immunosuppressor treatment should be started early to achieve complete cure and should be followed by hematopoietic stem cell transplantation.	11827656
Cytomegalovirus Infections, Virus Diseases, Leukoencephalopathy	Stem Cell Exhaustion	Unusual viral infections (progressive multifocal leukoencephalopathy and cytomegalovirus disease) after high-dose chemotherapy with autologous blood stem cell rescue and peritransplantation rituximab.	11830505
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Efforts to reduce relapse of non-Hodgkin lymphoma after autologous transplantation have included ex vivo stem cell selection and/or peritransplantation immunotherapy.	11830505
Cytomegalovirus Infections, infectious - Entity Risk	Stem Cell Exhaustion	The late infectious and immunologic consequences of these maneuvers are not well understood, although an increase in early cytomegaloviral disease after CD34(+) stem cell selection and an alteration in immunoglobulin and T-cell recovery after peritransplantation rituximab has been noted.	11830505
Cytomegalovirus Retinitis, Pneumonitis, CTCAE, Leukoencephalopathy	Stem Cell Exhaustion	We report the first 2 cases of progressive multifocal leukoencephalopathy caused by JC papovavirus after autologous peripheral blood stem cell transplantation and a case each of cytomegalovirus retinitis and pneumonitis.	11830505
Graft-vs-Host Disease, Acute respiratory failure	Stem Cell Exhaustion	We report here a fatal case of a 3-year-old child who developed acute respiratory failure coinciding with the onset of hyper-acute graft versus host disease (aGVHD) after allogeneic peripheral stem cell transplantation.	11835332
T-Cell Lymphoma, Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	Autologous peripheral stem cell transplantation for aggressive hemophagocytic syndrome associated with T-cell lymphoma: case study and review.	11835334
Aggressive course, T-Cell Lymphoma	Stem Cell Exhaustion	We describe a 29-year-old male with aggressive HPS and T-cell lymphoma managed successfully with high-dose chemotherapy and autologous peripheral stem cell transplantation (APSCT), in remission at 41 months of follow-up.	11835334
Hantavirus Infections	Stem Cell Exhaustion	In reviewing the literature, this case illustrates the 2nd longest surviving individual post stem cell transplant for aggressive HPS.	11835334
Chromosome Aberrations, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The development of a clone with additional cytogenetic abnormalities in CML has only been reported after leukemogenic treatment, stem cell transplantation or interferon.	11839390
Multiple Myeloma	Stem Cell Exhaustion	Negative selection of peripheral blood stem cells to support a tandem autologous transplantation programme in multiple myeloma.	11841418
Mycoses	Stem Cell Exhaustion	Invasive fungal infections after allogeneic peripheral blood stem cell transplantation: incidence and risk factors in 395 patients.	11841455
Mycoses	Stem Cell Exhaustion	We have analysed the incidence and risk factors for the occurrence of invasive fungal infections (IFI) among 395 recipients of an allogeneic peripheral blood stem cell transplantation (PBSCT) from a human leucocyte antigen (HLA)-identical sibling.	11841455
Polycythemia Vera, Myeloproliferative disease, MVD gene	Stem Cell Exhaustion	Polycythaemia vera (PV) is a myeloproliferative disorder (MPD) thought to result from transformation of a haemopoietic stem cell.	11843821
Acute GVH disease, Chimerin 1	Stem Cell Exhaustion	Mixed chimaerism is common at the time of acute graft-versus-host disease and disease response in patients receiving non-myeloablative conditioning and allogeneic stem cell transplantation.	11843830
Neoplasms	Stem Cell Exhaustion	The pluripotent progenitor cells of the olfactory neurons may be the origin and their existence explains why various neoplasms with neuronal and epithelial differentiation arise from the olfactory mucosa.	11844067
Non-Neoplastic Hematologic and Lymphocytic Disorder	Stem Cell Exhaustion	Allogeneic peripheral blood stem cell transplantation (PBSCT) was performed in children and adolescents for the treatment of malignant (n = 49) and nonmalignant hematological disease (n = 8).	11846353
Hepatitis C, Hollings Cancer Center	Stem Cell Exhaustion	The clinicopathologic findings in patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) positive for biliary markers, those related to the hepatic progenitor cells, were investigated.	11849748
Hepatitis C	Stem Cell Exhaustion	Some HCCs develop from the hepatic progenitor cells in patients with HCV infection and prior HBV infection, which may affect the clinicopathologic findings of HCV-related HCCs.	11849748
Rheumatoid Arthritis	Stem Cell Exhaustion	Autologous stem cell transplantation in the treatment of refractory rheumatoid arthritis.	11850603
Rheumatoid Arthritis	Stem Cell Exhaustion	The concept of using high-dose immunosuppressive treatment (HDIT) with autologous stem cell transplantation (ASCT) to treat patients with refractory rheumatoid arthritis has been provided by animal studies and anecdotal case reports.	11850603
Thalassemia	Stem Cell Exhaustion	Haematopoietic stem cell transplantation for thalassaemia major in Hong Kong: prognostic factors and outcome.	11850702
Hemolysis (biological function)	Stem Cell Exhaustion	Massive haemolysis in a group A recipient of a group O peripheral blood stem cell allogeneic transplant.	11851944
Hyperactive behavior	Stem Cell Exhaustion	The stem cell graft contained 2.85 x 10(6) CD34+ cells kg(-1) and we speculate there was B cell hyperactivity following the withdrawal of methotrexate in the donor and this went unchecked by the omission of methotrexate in the GVHD prophylaxis of the recipient.	11851944
Precursor cell lymphoblastic lymphoma, Psoriasis	Stem Cell Exhaustion	A 28-year-old man with lymphoblastic lymphoma received G-CSF mobilized stem cells from his HLA identical sister, who had been taking methotrexate for psoriasis until 1 month prior to harvest.	11851944
Encephalitis	Stem Cell Exhaustion	Case report: human herpesvirus 7 associated fatal encephalitis in a peripheral blood stem cell transplant recipient.	11857527
Acute lymphocytic leukemia	Stem Cell Exhaustion	An 8-year-old girl received a peripheral blood stem cell transplant for relapsed acute lymphoblastic leukaemia.	11857527
Simplexvirus	Stem Cell Exhaustion	We compared the efficacy and costs of valacyclovir in preventing HSV reactivation among HSV seropositive autologous progenitor cell transplantation (APCT) patients with historical controls in whom intravenous acyclovir or no HSV prophylaxis were used.	11859400
Herpes Simplex Infections	Stem Cell Exhaustion	Valacyclovir prophylaxis for the prevention of Herpes simplex virus reactivation in recipients of progenitor cells transplantation.	11859400
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	platelet-secreted) PDGF and PF-4 can function as regulators of leukemic hematopoiesis and possibly also modulate the function of residual AML cells in peripheral blood stem cell grafts.	11860452
PAFAH1B1 wt Allele	Stem Cell Exhaustion	CD34(+) cells from the marrow of patients with MDS were cultured for 10 days in serum-containing medium with Epo, stem cell factor, insulin-like growth factor 1, and steroid hormones until they reached the proerythroblast stage.	11861273
Rheumatoid Arthritis, HEMATOPOIESIS IMPAIRED	Stem Cell Exhaustion	Based on previous reports for impaired hematopoiesis in rheumatoid arthritis (RA), and in view of the current interest in exploring the role of autologous stem cell transplantation (ASCT) as an alternative treatment in patients with resistant disease, we have evaluated bone marrow (BM) progenitor cell reserve and function and stromal cell function in 26 patients with active RA.	11861275
Rheumatoid Arthritis	Stem Cell Exhaustion	The role of these abnormalities on stem cell harvesting and engraftment in RA patients undergoing ASCT remains to be clarified.	11861275
Rheumatoid Arthritis, Tumor necrosis	Stem Cell Exhaustion	Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: evidence for a tumor necrosis factor alpha-mediated effect.	11861275
Rheumatoid Arthritis	Stem Cell Exhaustion	We found that RA patients exhibited low number and increased apoptosis of CD34(+) cells, defective clonogenic potential of BM mononuclear and purified CD34(+) cells, and low progenitor cell recovery in LTBMCs, compared with healthy controls (n = 37).	11861275
Rheumatoid Arthritis	Stem Cell Exhaustion	We concluded that BM progenitor cell reserve and function and BM stromal cell function are defective in RA probably due, at least in part, to a TNF alpha-mediated effect.	11861275
Corneal dystrophy, Lattice type 3, Amyloidosis	Stem Cell Exhaustion	Limbal stem cell transplantation for the treatment of subepithelial amyloidosis of the cornea (gelatinous drop-like dystrophy).	11862090
Toxic effect	Stem Cell Exhaustion	We studied the toxicity and efficacy of reduced intensity conditioning followed by allogeneic stem cell transplantation in 50 patients over 50 years old or with relative contraindications against myeloablative regimens.	11869943
Acute leukemia	Stem Cell Exhaustion	There were 18, 10 and 27 ICU admissions per 100 treatments in patients undergoing chemotherapy for acute leukaemia, autologous and allogeneic stem cell transplantation (p <0.005) respectively.	11875752
Hematologic Neoplasms, Fever of Unknown Origin	Stem Cell Exhaustion	Sixty-one patients with hematologic malignancies developing 69 episodes of neutropenic FUO after chemotherapy or hematopoietic stem cell transplantation were included in the study.	11876025
Pterygium	Stem Cell Exhaustion	To provide new stem cell source for injured limbus with limbal epithelial autograft transplantation is a reasonable therapeutic method for treatment of pterygium.	11877236
Hemoglobinopathies	Stem Cell Exhaustion	These results demonstrate for the first time that viral-mediated globin gene transfer in hematopoietic stem cells effectively treats a severe hemoglobin disorder.	11877258
PAFAH1B1 wt Allele	Stem Cell Exhaustion	The observations made in this study should facilitate the design of prospective trials aimed at improving the results of unrelated donor stem cell transplantation for MDS.	11877264
Toxic effect, Primary Myelofibrosis	Stem Cell Exhaustion	Standard myeloablative conditioning prior to allogeneic hematopoietic stem cell (HSC) transplantation has been associated with significant toxicity in patients older than 45 years of age with myelofibrosis with myeloid metaplasia (MMM).	11877308
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	To evaluate the safety, feasibility, and efficacy of allogeneic stem cell transplantation (SCT) for acute myelogenous leukemia (AML) in a young female coinfected by HIV and HCV undergoing highly active antiretroviral therapy (HAART).	11882366
Malignant Neoplasms, Acquired Immunodeficiency Syndrome	Stem Cell Exhaustion	One may therefore reconsider the current exclusion of patients with AIDS and a concomitant lethal malignancy from programs of high-dose chemotherapy and stem cell transplantation, as suggested by this report.	11882366
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Highly active antiretroviral therapy and allogeneic CD34(+) peripheral blood progenitor cells transplantation in an HIV/HCV coinfected patient with acute myeloid leukemia.	11882366
Toxic effect	Stem Cell Exhaustion	We prospectively evaluated the efficacy and toxicity of a preemptive protocol with ganciclovir at a reduced initial dose in 40 patients who achieved engraftment after allogeneic hematopoietic stem cell transplantation.	11889432
Stem cells	Stem Cell Exhaustion	It has been suggested [13] that the anti-apoptotic function of amnion may prevent stem cell loss in such eyes [42], thus it appears logical to offer an amniotic membrane graft first, before stem cell transplantation, which may entrain complications in the donor eye if autografted [43] or because of the rejection risk of an allograft.	11894530
Burn injury	Stem Cell Exhaustion	The technique was not sufficient to control the effect of corneal anaesthesia in two eyes [40] or in chemical burns suggesting that amniotic membrane alone is insufficient to promote corneal healing in the absence of limbal stem cells.	11894530
Anemia	Stem Cell Exhaustion	A 56-year-old-man who had refractory anemia with an excess of blasts underwent an allogeneic peripheral blood stem cell transplantation (PBSCT) from his brother after preparation with melphalan and fludarabin.	11895513
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Autologous stem cell transplantation for advanced acute myeloid leukemia.	11896426
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We studied the efficacy of a two-step approach to autologous stem cell transplantation for patients with advanced acute myeloid leukemia.	11896426
Lymphoma, Non-Hodgkin, Familial, HD Term Type	Stem Cell Exhaustion	To test this approach, 55 patients with relapsed/refractory or high-risk NHL or relapsed/refractory HD were enrolled in the following protocol: stem cell mobilization: cyclophosphamide (4.5 g/m(2)) + etoposide (2.0 g/m(2)) followed by GM-CSF or G-CSF; high-dose therapy: gemcitabine (1.0 g/m(2)) on day -5, BCNU (300 mg/m(2)) + gemcitabine (1.0 g/m(2)) on day -2, melphalan (140 mg/m(2)) on day -1, blood stem cell infusion on day 0; post-transplant immunotherapy (B cell NHL): rituxan (375 mg/m(2)) weekly for 4 weeks + GM-CSF (250 microg thrice weekly) (weeks 4-8); post-transplant involved-field radiotherapy (HD): 30-40 Gy to pre-transplant areas of disease (weeks 4-8); post-transplant consolidation chemotherapy (all patients): dexamethasone (40 mg daily)/cyclophosphamide (300 mg/m(2)/day)/etoposide (30 mg/m(2)/day)/cisplatin (15 mg/m(2)/day) by continuous intravenous infusion for 4 days + gemcitabine (1.0 g/m(2), day 3) (months 3 + 9) alternating with dexamethasone/paclitaxel (135 mg/m(2))/cisplatin (75 mg/m(2)) (months 6 + 12).	11896427
Sepsis, Myelosuppression	Stem Cell Exhaustion	Transient grade 3-4 myelosuppression was common and one patient died from neutropenic sepsis, but no patients required an infusion of backup stem cells.	11896427
Respiratory Syncytial Virus Infections	Stem Cell Exhaustion	Respiratory syncytial virus infection following hematopoietic stem cell transplantation.	11896429
Childhood Breast Carcinoma	Stem Cell Exhaustion	Interim analysis of the use of the anti-idiotype breast cancer vaccine 11D10 (TriAb) in conjunction with autologous stem cell transplantation in patients with metastatic breast cancer.	11899383
Childhood Breast Carcinoma	Stem Cell Exhaustion	The anti-idiotype monoclonal antibody breast cancer vaccine 11D10 (TriAb) was administered before and after autologous stem cell transplantation (ASCT) in 45 patients with metastatic breast cancer whose disease was responsive to conventional chemotherapy.	11899383
Neoplasms	Stem Cell Exhaustion	Mesenchymal stem cells underlying these tumours may show divergent mesenchymal differentiation.	11903599
Cytomegalovirus Retinitis	Stem Cell Exhaustion	Intravitreal sustained-release ganciclovir implants for severe bilateral cytomegalovirus retinitis after stem cell transplantation.	11906315
Retinitis, Acute lymphocytic leukemia	Stem Cell Exhaustion	To describe the treatment of cytomegalovirus (CMV) retinitis with intravitreal sustain-release ganciclovir devices in a 16-year-old patient in third remission of acute lymphoblastic leukemia after stem cell transplantation.	11906315
Cytomegalovirus Infections	Stem Cell Exhaustion	The patient received a stem cell transplant from an unrelated bone marrow donor after which he contracted a serious CMV infection manifested in the lungs and retinae.	11906315
Cytomegalovirus Retinitis, Communicable Diseases	Stem Cell Exhaustion	The intravitreal ganciclovir implant provides safe and effective therapy against CMV retinitis, and should be considered in patients acquiring the infection after stem cell transplantation.	11906315
Primary Myelofibrosis	Stem Cell Exhaustion	CD34+ progenitor cells in idiopathic (primary) myelofibrosis: a comparative quantification between spleen and bone marrow tissue.	11907788
Unknown (origin) (qualifier value), Primary Myelofibrosis	Stem Cell Exhaustion	Previous studies on idiopathic (primary) myelofibrosis (IMF) are in keeping with the finding of an increased number of circulating CD34+ progenitor cells.	11907788
B-Cell Lymphomas	Stem Cell Exhaustion	High-dose chemotherapy with hematopoietic stem cell transplantation is effective for nasal and nasal-type CD56+ natural killer cell lymphomas.	11911411
Blastic plasmacytoid dendritic cell neoplasm	Stem Cell Exhaustion	Our clinical experience suggests that myeloablative high-dose chemotherapy and bone marrow rescue by hematopoietic stem cell transplantation may be an effective salvage treatment modality for refractory NK-cell lymphomas and could be considered as a part of the initial therapy for these patients.	11911411
Multiple Myeloma	Stem Cell Exhaustion	Daily tamoxifen was given to 12 consecutive multiple myeloma patients who either relapsed following autologous stem cell transplantation (11) or had progressive disease on conventional chemotherapy (1).	11911415
Fever of Unknown Origin, Neutropenia, Fever, Infectious Lung Disorder, Pulmonary Aspergillosis	Stem Cell Exhaustion	The study was conducted in four patient groups: those with fever of unknown origin (FUO) during neutropenia, suspected pulmonary infection (PI), or nonpulmonary aspergillosis (NPA) and those undergoing surveillance (S) after hematopoietic stem-cell transplantation (HSCT).	11919250
Specialty Type - cancer, Referral type - Psychiatric	Stem Cell Exhaustion	Psychiatric morbidity and impact on hospital length of stay among hematologic cancer patients receiving stem-cell transplantation.	11919251
Mental disorders	Stem Cell Exhaustion	To determine the prevalence of psychiatric disorders during hospitalization for hematopoietic stem-cell transplantation (SCT) and to estimate their impact on hospital length of stay (LOS).	11919251
Lymphoma, Non-Hodgkin, Acute lymphocytic leukemia	Stem Cell Exhaustion	Acute lymphoblastic leukemia (P =.009), non-Hodgkin's lymphoma (P =.04), use of peripheral-blood stem cells (P <.001), second year of study (P <.001), and third year of study (P <.001) were associated with a shorter LOS.	11919251
Kidney Failure, Multiple Myeloma	Stem Cell Exhaustion	Are myeloma patients with renal failure candidates for autologous stem cell transplantation?	11920166
Kidney Failure, Morular Metaplasia of the Endometrium	Stem Cell Exhaustion	The aim of this study was to analyze the outcome of MM patients with renal insufficiency undergoing autologous stem cell transplantation (ASCT), including the evaluation of the quality of PB stem cell collections, kinetics of engraftment, transplant-related mortality, response to high dose chemotherapy and survival.	11920166
Intravascular hemolysis, Hemoglobinuria, CTCAE 3.0, Cytopenia, Thrombosis	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria is an acquired clonal stem cell disorder characterized by the decrease or absence of glycosylphosphatidylinositol-anchored molecules from the surface of the affected cells, such as CD55 and CD59, resulting in chronic intravascular hemolysis, cytopenia and increased tendency to thrombosis.	11920231
Degenerative polyarthritis	Stem Cell Exhaustion	Reduced chondrogenic and adipogenic activity of mesenchymal stem cells from patients with advanced osteoarthritis.	11920406
Degenerative polyarthritis	Stem Cell Exhaustion	These results raise the possibility that the increase in bone density and loss of cartilage that are characteristic of OA may result from changes in the differentiation profile of the progenitor cells that contribute to the homeostatic maintenance of these tissues.	11920406
Respiratory Tract Infections, Chlamydia	Stem Cell Exhaustion	Chlamydia pneumoniae respiratory infection after allogeneic stem cell transplantation.	11923709
Respiratory Tract Infections	Stem Cell Exhaustion	We describe C. pneumoniae lower respiratory tract infection in a 19-year-old male after allogeneic stem cell transplantation.	11923709
Respiratory Tract Infections	Stem Cell Exhaustion	To the best of our knowledge, this is the first report of C. pneumoniae respiratory infection after stem cell or marrow transplantation.	11923709
Lymphoma, Follicular, Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	In contrast, CD20 expression on chronic lymphocytic leukemia, follicular non-Hodgkin's lymphoma, healthy donor B cells, and progenitor cells was unaffected by IFN-y.	11924912
Graft-vs-Host Disease, Pulmonary Aspergillosis, Central neuroblastoma	Stem Cell Exhaustion	A 16-year-old girl had suffered from chronic graft versus host disease (GVHD) caused by peripheral blood stem cell transplantation (PBSCT) after chemotherapy for neuroblastoma and pulmonary aspergillosis of the right upper lobe.	11925893
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	Long-term support of hematopoiesis by a single stem cell clone in patients with paroxysmal nocturnal hemoglobinuria.	11929762
Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hematopoietic stem cell disorder characterized by clonal blood cells that are deficient in glycosylphosphatidylinositol-anchored proteins because of somatic mutations of the PIG-A gene.	11929762
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	Therefore, one stem cell clone can sustain hematopoiesis for 6 to 10 years in patients with PNH.	11929762
Tumor necrosis	Stem Cell Exhaustion	Tissue sections were tested using immunohistochemistry for the expression of keratinocyte-derived cytokines with stimulating activity, such as granulocyte-monocyte colony stimulating factor (GM-CSF), basic fibroblastic growth factor (bFGF), and stem cell factor (SCF) or with inhibiting activity, such as interleukin 6 (IL-6) and tumour necrosis factor alpha (TNF-alpha) on melanocytes.	11936274
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Hematopoietic stem cell transplantation for advanced myelodysplastic syndrome after conditioning with busulfan and fractionated total body irradiation is associated with low relapse rate but considerable nonrelapse mortality.	11939606
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Few therapeutic options are presently available for patients with multiple myeloma (MM) who relapse after autologous or allogeneic stem cell transplantation, or for patients who are refractory to conventional chemotherapy and not eligible for salvage high-dose therapy.	11940485
Head of pancreas, Obstruction of biliary tree, Embryonal sarcoma of liver	Stem Cell Exhaustion	In 30 patients with pancreatic head cancer after surgical treatment of biliary ducts obstructions using biliodigestive shunting method the suspensions, containing stem cells of embryonal liver, were transplanted.	11944235
Hematologic Neoplasms	Stem Cell Exhaustion	A total of 16 scheduled patients with hematological malignancies were enrolled for comparison of their data with conventional stem cell transplantation (n = 19).	11948108
Infection	Stem Cell Exhaustion	Although the recovery of CD4+ cells was significantly slower (P = 0.02) in RIST than in conventional stem cell transplantation, the incidence of clinically documented infections was not significantly different between the two groups.	11948108
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Improved outcome in adult acute myeloid leukemia is almost entirely restricted to young patients and associated with stem cell transplantation.	11952822
Depressive Syndrome, malignant disease, Cessation of life	Stem Cell Exhaustion	Association of depressive syndrome and early deaths among patients after stem-cell transplantation for malignant diseases.	11956273
Depression, CTCAE	Stem Cell Exhaustion	However, depression is not well studied in the setting of hematopoietic stem-cell transplantation (HSCT).	11956273
Lymphoma, Follicular	Stem Cell Exhaustion	Successful autologous peripheral blood stem cell transplantation in transformed follicular lymphoma previously treated with radioimmunotherapy (iodine (131)I tositumomab).	11960274
Lymphoma	Stem Cell Exhaustion	While the use of radioimmunotherapy for lymphoma increases, the feasibility and efficacy of autologous stem cell transplant for subsequent relapse remains unknown.	11960274
leukemia	Stem Cell Exhaustion	Less intense conditioning with fludarabine, cyclophosphamide, idarubicin and etoposide (FCIE) followed by allogeneic unselected peripheral blood stem cell transplantation in elderly patients with leukemia.	11960336
Toxic effect, leukemia	Stem Cell Exhaustion	The objective of this study was to assess toxicity and feasibility of achieving engraftment of allogeneic blood progenitor cells following nonmyeloablative conditioning according to the FCIE protocol (fludarabine 25 mg/m(2)/day, days -7 to -3; cyclophosphamide 200 mg/m(2)/day, days -7 to -3; idarubicin 12 mg/m(2)/day, days -7 to -5; etoposide 250 mg/m(2)/day, days -4 to -3) in elderly patients with leukemia.	11960336
Toxic effect, leukemia	Stem Cell Exhaustion	The data from this pilot study in elderly patients with leukemia show that the combination of primarily immunosuppressive (FC) and antileukemic (IE) drugs for nonmyeloablative conditioning has moderate nonhematological toxicity and allows engraftment of allogeneic blood progenitor cells.	11960336
Graft-vs-Host Disease, Stable chronic Graft vs Host Disease, Acute GVH disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Low TREC-containing CD4 T cell counts were associated with older patient age (r=-0.41, P=0.01) but not with donor age, graft type (marrow vs. blood stem cells), CD34 cell dose, conditioning (with vs. without irradiation), acute graft-versus-host disease (aGVHD), or chronic graft-versus-host disease (cGVHD) in multivariate analysis.	11965050
Graft-vs-Host Disease, Peripheral Stem Cell Transplantation, Heat-Shock Response	Stem Cell Exhaustion	Antibodies to 70 kD and 90 kD heat shock proteins are associated with graft-versus-host disease in peripheral blood stem cell transplant recipients.	11966775
Heat-Shock Response	Stem Cell Exhaustion	Based on our previous studies that showed an involvement of 70kD heat shock protein (hsp70) in the pathology of acute GVHD in a rat model, we determined serum levels of antibodies to hsp70, hsp90 and hsp60 in human recipients after allogeneic peripheral blood stem cell transplantation (PBSCT).	11966775
Prostatic Intraepithelial Neoplasias, Adenocarcinoma of prostate, Benign prostatic hypertrophy	Stem Cell Exhaustion	We conducted an expression analysis of prostate stem cell antigen (PSCA)in normal urogenital tissues, benign prostatic hyperplasia (n = 21), prostatic intraepithelial neoplasia (n = 33), and primary (n = 137) and metastatic (n = 42) prostate adenocarcinoma, using isotopic in situ hybridization on tissue microarrays.	11980648
Toxic effect	Stem Cell Exhaustion	Future use of this approach will require strategies to minimize dose-limiting toxicity of BCNU such as regional delivery or hematopoietic stem-cell protection.	11980998
Aggressive Non-Hodgkin Lymphoma, Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	To determine whether the source of autologous hematopoietic stem cells altered the clinical outcomes of patients undergoing high-dose chemotherapy and hematopoietic stem-cell transplantation (HSCT) for aggressive non-Hodgkin's lymphoma (NHL).	11981006
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	Of 105 high-risk, persistent, or relapsed NHL patients slated for an autologous HSCT entered onto this trial, 93 eligible patients were randomized to receive cytokine-naive autologous bone marrow transplantation (ABMT) (n = 46) or mobilized peripheral-blood stem-cell transplantation (PBSCT) (n = 47).	11981006
Graft-vs-Host Disease	Stem Cell Exhaustion	To decrease the incidence of graft-versus-host disease (GVHD) observed after nonmyeloablative stem cell transplantation (NMSCT), we studied the feasibility of CD8-depleted or CD34-selected NMSCT followed by CD8-depleted preemptive donor lymphocyte infusion (DLI) given in incremental doses on days 40 and 80.	11983101
synovial sarcoma	Stem Cell Exhaustion	Synovial sarcoma in an 11-year-old Japanese girl relapsed 5 months after autologous stem cell transplantation.	11990310
Cognitive Therapy	Stem Cell Exhaustion	Cognitive, behavioral, and social outcome in survivors of childhood stem cell transplantation.	11990696
Juvenile Myelomonocytic Leukemia, Hypersensitivity	Stem Cell Exhaustion	In vitro cell culture studies of bone marrow and peripheral blood progenitor cells from patients with juvenile myclomonocytic leukemia (JMML) consistently show spontaneous proliferation and selective hypersensitivity to granulocyte-macrophage colony-stimulating factor (GM-CSF).	11990701
Congenital neurologic anomalies	Stem Cell Exhaustion	Intracerebral transplantation of mesenchymal stem cells into acid sphingomyelinase-deficient mice delays the onset of neurological abnormalities and extends their life span.	11994407
nervous system disorder	Stem Cell Exhaustion	We have used a knockout mouse model of NPD (ASMKO mice) to evaluate the effects of direct intracerebral transplantation of bone marrow-derived mesenchymal stem cells (MSCs) on the progression of neurological disease in this disorder.	11994407
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin, Therapy-related myelodysplastic syndrome, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Several recent reports have suggested that patients with non-Hodgkin's lymphomas (NHL) who undergo autologous stem cell transplantation (ASCT) are at increased risk of developing therapy-related myelodysplastic syndrome (tMDS) and acute myelogenous leukemia (tAML).	11996478
EBV-Related Sarcoma	Stem Cell Exhaustion	Epstein-Barr virus-associated lymphoma in a child undergoing an autologous stem cell rescue.	11998794
Neoplasms	Stem Cell Exhaustion	In this article, a patient with EBV-lymphoma after autologous stem cell rescue for treatment of a nonhematologic solid tumor is described.	11998794
Neoplasms	Stem Cell Exhaustion	He had previously received both local tumor bed and craniospinal radiation therapy together with intensive myeloablative alkylator chemotherapy before autologous stem cell rescue.	11998794
Lymphadenopathy	Stem Cell Exhaustion	It is concluded that EBV-LPD should be included in the differential diagnosis in patients in whom lymphadenopathy develops after autologous stem cell rescue.	11998794
Acute GVH disease	Stem Cell Exhaustion	Ocular manifestation of acute graft-versus-host disease after allogeneic peripheral blood stem cell transplantation.	11999366
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 26-year-old woman with acute myeloid leukemia underwent allogeneic peripheral blood stem cell transplantation from an HLA-identical brother.	11999366
IgD myeloma	Stem Cell Exhaustion	Meningeal relapse after double peripheral blood stem cell transplantation in IgD myeloma.	12002772
IgD myeloma	Stem Cell Exhaustion	A 54-year-old man diagnosed with IgD myeloma (stage IIIA) in complete remission (CR) received peripheral blood stem cell transplantation (PBSCT) twice with an interval of 4 months using high-dose melphalan 200mg/m2.	12002772
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	We report a 34-year-old male with relapsed non-Hodgkin's lymphoma (NHL) after autologous peripheral blood stem cell transplantation successfully treated with unrelated cord blood transplantation (CBT).	12002775
leukemia	Stem Cell Exhaustion	Prior invasive pulmonary and cerebellar mucormycosis is not a primary contraindication to perform an autologous stem cell transplatation in leukemia.	12002776
Acidophil Stem Cell Pituitary Gland Adenoma	Stem Cell Exhaustion	Acidophilic stem cell adenoma may be responsible for these phenomena.	12008749
Small cell carcinoma of lung	Stem Cell Exhaustion	Intensive chemotherapy with whole blood stem-cell support and concurrent chest radiotherapy in small cell lung cancer: a phase I/II trial.	12009245
Small cell carcinoma of lung	Stem Cell Exhaustion	In a prospective study, we treated 18 patients with limited SCLC with an intensive sequential single agent (ifosfamide, carboplatin, etoposide and paclitaxel, (ICE-T)) chemotherapy with the support of unprocessed stem-cell enriched whole blood and G-CSF and concomitant bi-fractionated chest radiotherapy (60 Gy).	12009245
Toxic effect	Stem Cell Exhaustion	The aim of this study was to evaluate the efficacy and toxicity as well as the eligibility to stem cell transplantation (SCT) in a series of 7 patients with relapsing APL, managed with ATO.	12010661
Acute leukemia	Stem Cell Exhaustion	This is suggestive of complex multistep tumorigenic mechanisms and is supportive of the hypothesis that CD4(+), CD56(+) DC2 acute leukemia may arise from an undifferentiated nonmyeloid nonlymphoid progenitor cell.	12010820
Neutropenia, streptococcal bacteremia	Stem Cell Exhaustion	Despite the use of levofloxacin prophylaxis during the neutropenic period after autologous peripheral blood stem cell transplantation, viridans group (VG) streptococcal bacteremia developed in 6 (16.2%) of 37 patients who underwent transplantation between 1 January and 25 February 2001 at the Mayo Clinic in Rochester, Minnesota.	12015693
Neurilemmoma, Calcinosis, Hemorrhage	Stem Cell Exhaustion	Histological and immunohistochemical examination, including staining for CD-34, a myeloid progenitor cell antigen, found highly degenerated schwannoma with collagen-rich tissue, calcification, formation of bone, abnormal vessels of various sizes, and old haemorrhage with marked haemosiderin-laden macrophages.	12021889
Neoplasms	Stem Cell Exhaustion	Despite this important role of basal cells, our findings demonstrate that all cell types principally have to be considered as potential progenitor cells for salivary gland tumors.	12021927
Polycythemia Vera	Stem Cell Exhaustion	The predictive value of clonogenic stem cell assays for the diagnosis of polycythaemia vera.	12028027
Polycythemia Vera	Stem Cell Exhaustion	Spontaneous growth of erythroid progenitor cells is one of the hallmarks of polycythaemia vera (PV).	12028027
Multiple Myeloma	Stem Cell Exhaustion	A phase I-II study of high-dose (HD) alkylating agents in newly diagnosed patients with multiple myeloma after maximum response to Z-Dex (idarubicin, dexamethasone) therapy and DHAP (cisplatin, HD cytosine arabinoside, dexamethasone), stem cell mobilization is reported.	12028028
Multiple Myeloma	Stem Cell Exhaustion	The endogenous granulocyte colony-stimulating factor response following autologous peripheral blood stem cell transplantation is impaired in patients with myeloma.	12028037
Hodgkin Disease, Lymphoma, Non-Hodgkin, Neoplasms, Multiple Myeloma	Stem Cell Exhaustion	Granulocyte colony-stimulating factor (G-CSF) levels were studied in 23 patients (10 myeloma, 13 relapsed Hodgkin's disease, non-Hodgkin's lymphoma or germ cell tumours), post autologous peripheral blood stem cell transplantation (PBSCT).	12028037
Neoplasms	Stem Cell Exhaustion	The clinical relevance of tumor cell purging of hematopoietic progenitor cell grafts has yet to be conclusively determined.	12028831
Neoplasms	Stem Cell Exhaustion	CD34 selection alone or in combination with negative selection can result in a significant reduction of contaminating tumor cells in the peripheral blood progenitor cell autograft.	12028831
Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	Tumor cell depletion of peripheral blood progenitor cells using positive and positive/negative selection in metastatic breast cancer.	12028831
Multiple Myeloma	Stem Cell Exhaustion	Different patterns of relapse after autologous peripheral blood stem cell transplantation in multiple myeloma: clinical results of 280 cases from the Spanish Registry.	12031917
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Autologous peripheral blood stem cell (PBSC) transplantation is widely used to treat patients with multiple myeloma (MM).	12031917
Acute leukemia	Stem Cell Exhaustion	The morphologic, immunophenotypic, genotypic, genomic, and functional features of an undifferentiated acute leukemia with stem cell features are reported.	12036900
Noninfiltrating Intraductal Carcinoma	Stem Cell Exhaustion	Thirteen cases (eight DCIS and five IDC) showed expression of CK8, CK14, CK18, vimentin, and EGFR, consistent with a stem cell phenotype, whereas 44 cases (27 DCIS and 17 IDC) showed expression of CK8 and CK1, weak or negative expression of CK18, but were negative for vimentin and EGFR, consistent with a luminal cell phenotype.	12037031
Noninfiltrating Intraductal Carcinoma	Stem Cell Exhaustion	DCIS and IDC cases with a stem cell phenotype were ER/PgR negative and intermediately or poorly differentiated.	12037031
Noninfiltrating Intraductal Carcinoma	Stem Cell Exhaustion	Both DCIS and IDC cases with a stem cell phenotype were p53 positive and bcl-2 negative by immunohistochemistry.	12037031
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy (HDT) with autologous peripheral blood progenitor cell (PBPC) transplant has been increasingly used for newly diagnosed multiple myeloma (MM) in recent years.	12038448
Neutropenia	Stem Cell Exhaustion	In order to assess the effect of delaying G-CSF administration after autologous peripheral blood progenitor cell (PBPC) transplantation on the duration of neutropenia, 87 patients were randomized to receive G-CSF 5 microg/kg/day starting on day +1 (n = 45) or +5 (n = 42) following PBPC transplantation, until recovery of the neutrophils.	12040471
Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired stem cell disorder characterized by the deficiency of all proteins anchored to the membrane by the glycosyl-phosphatidylinositol (GPI) anchor.	12041678
Childhood Breast Carcinoma	Stem Cell Exhaustion	High CD34 cell doses do not worsen regimen-related toxicity or early mortality after autologous blood stem cell transplantation for breast cancer.	12042047
Neoplasms	Stem Cell Exhaustion	It is likely that these tumors may originate from spinal dura mater mesenchymal stem cells and from the intracerebral perivascular pial sheath or the brain vessel walls themselves, respectively.	12049182
Rheumatoid Arthritis	Stem Cell Exhaustion	Bone marrow CD34+ cells from RA patients that had been stimulated with stem cell factor and GM-CSF for 3-4 weeks (>90% CD14+ HLA-DR+ cells, <0.5% CD19+ B cells, and <0.5% CD3+ T cells; MLC) induced the production of IgG much more effectively than that of IgM by highly purified B cells from healthy donors in the presence of IL-2 and IL-10.	12050184
Thalassemia	Stem Cell Exhaustion	Second transplant for a thalassemia patient after graft rejection: with immunosuppression and allogeneic peripheral blood stem cell.	12051594
TCL4 gene	Stem Cell Exhaustion	Interferon-alpha therapy following autologous peripheral blood stem cell transplantation for adult T cell leukemia/lymphoma.	12053149
TCL4 gene, Adult T-Cell Lymphoma/Leukemia	Stem Cell Exhaustion	In the present report, we describe a case of adult T cell leukemia/lymphoma (ATLL), a 58-year-old woman, successfully treated with interferon (IFN)-alpha following autologous peripheral blood stem cell transplantation (auto-PBSCT).	12053149
Liver Failure, Amyloidosis	Stem Cell Exhaustion	Successful sequential liver and stem cell transplantation for hepatic failure due to primary AL amyloidosis.	12055607
Primary amyloidosis	Stem Cell Exhaustion	This is the first reported patient with primary amyloidosis to undergo sequential liver and stem cell transplantation leading to resolution of the disease and only the second to undergo successful liver transplantation for this disorder.	12055607
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Factors influencing hematopoietic recovery after autologous blood stem cell transplantation in patients with acute myeloblastic leukemia and with non-myeloid malignancies.	12058232
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Factors influencing hematopoietic recovery (HR) after autologous blood stem cell transplantation (ABSCT) were analyzed in 73 patients with various non-myeloid malignancies (NMM), and in 58 patients with acute myeloblastic leukemia (AML).	12058232
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Our results confirm the slower HR after ABSCT in AML, and highlight the importance of progenitor cell dose in accelerating HR after ABSCT.	12058232
Hodgkin Disease	Stem Cell Exhaustion	Front-line high-dose therapy with autologous stem cell transplantation for high risk Hodgkin's disease: comparison with combined-modality therapy.	12058233
Hodgkin Disease, HD Term Type	Stem Cell Exhaustion	This retrospective study compares high-dose therapy (HDT) with autologous stem cell transplantation and combined-modality treatment (CT) as a first-line therapy for Hodgkin's disease (HD) for patients with both a clinical stage (CS) IV and/or a mediastinal mass > or =0.45 of the thoracic diameter (MM > or =0.45) at diagnosis, and an incomplete response after the first-line chemotherapy.	12058233
Crohn Disease, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Long-term endoscopic remission of crohn disease after autologous stem cell transplantation for acute myeloid leukaemia.	12059066
Autoimmune Diseases	Stem Cell Exhaustion	and there is now mounting evidence that autologous stem cell may be an effective treatment for severe autoimmune diseases.	12059066
Crohn Disease, Hematological Disease	Stem Cell Exhaustion	Here, we present the first long-term endoscopic follow-up of a patient with Crohn disease undergoing autologous stem cell transplantation for haematological disease.	12059066
Gastrointestinal inflammation, Crohn Disease	Stem Cell Exhaustion	This case suggests that autologous stem cell transplantation can change not only the clinical course, but also the natural history of intestinal inflammation in Crohn disease.	12059066
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	To investigate the effect of granulocyte colony-stimulating factor (G-CSF) donor-marrow priming on hematopoietic recovery and clinical outcome after allogeneic hematopoietic stem cell transplantation, we compared HILA-matched related marrow transplantation with and without G-CSF donor priming in a prospective randomized study for a homogeneous group of chronic myelogenous leukemia (CML) patients.	12064363
Small cell carcinoma of lung	Stem Cell Exhaustion	Autologous stem cell transplantation for small cell lung cancer.	12064365
Small cell carcinoma of lung	Stem Cell Exhaustion	We studied 103 patients receiving high-dose chemotherapy with autologous hematopoietic stem cell transplantation (SCT) for small cell lung cancer in 1989-1997 at 22 centers participating in the Autologous Blood and Marrow Transplant Registry.	12064365
Pregnancy Complications, Infectious	Stem Cell Exhaustion	Infectious complications after autologous CD34-selected peripheral blood stem cell transplantation.	12064366
Hematopoietic stem cells	Stem Cell Exhaustion	CD34 selection of peripheral hematopoietic blood stem cell products has been applied to reduce the risk of relapse after an autologous transplantation.	12064366
Cytomegalovirus Infections, Infection	Stem Cell Exhaustion	In this study, the incidence rate of infections other than CMV is reported in 32 patients who underwent myeloablative therapy followed by the infusion of CD34-selected autologous peripheral blood stem cells (PBSC) and compared to the rate in a contemporaneous group of 273 patients who received unselected autologous PBSC during the same time period.	12064366
Leukemia, Mast-Cell	Stem Cell Exhaustion	Low cost autologous peripheral blood stem cell transplantation performed in a municipal hospital for a patient with plasma cell leukaemia.	12067286
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Melphalan is widely used as a preparative agent in patients with multiple myeloma (MM) undergoing autologous stem cell transplantation (SCT).	12070031
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Involvement and functional impairment of the CD34(+)CD38(-)Thy-1(+) hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8.	12070035
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Clonality studies of mature cells suggest that the primary transformation event in myelodysplastic syndrome (MDS) most frequently occurs in a myeloid-restricted progenitor, a hypothesis supported by recent studies of purified CD34(+)Thy1(+) hematopoietic stem cells (HSCs) in cases with trisomy 8 (+8).	12070035
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Finally, in advanced cases of MDS, the MDS reconstituting activity is exclusively derived from the minor CD34(+)CD38(-) HSC population, demonstrating that MDS stem cells have a similar phenotype as normal HSCs, potentially complicating the development of autologous transplantation for MDS.	12070035
Cytopenia	Stem Cell Exhaustion	High-dose CD34+ cells are not clinically relevant in reducing cytopenia and blood component consumption following myeloablative therapy and peripheral blood progenitor cell transplantation as compared with standard dose.	12076291
Mycosis Fungoides	Stem Cell Exhaustion	Induction of complete remission of advanced stage mycosis fungoides by allogeneic hematopoietic stem cell transplantation.	12077596
Toxic effect, Malignant Neoplasms	Stem Cell Exhaustion	Allogeneic stem cell transplantation is curative for certain cancers, but the high doses of chemotherapy/radiotherapy lead to toxicity.	12091334
Mastocytosis	Stem Cell Exhaustion	Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene.	12091362
Mastocytosis, Mastocytosis, Systemic	Stem Cell Exhaustion	These results show that mastocytosis is a disorder of a pluripotential hematopoietic progenitor cell that gives rise to B cells and monocytes in addition to mast cells and that the affected clone shows variable expansion in these lineages in the peripheral blood of patients with systemic mastocytosis.	12091362
Myeloid	Stem Cell Exhaustion	This translocation creates a fusion protein consisting of the acute myeloid leukemia-1 transcription factor and the eight-twenty-one corepressor (AML1 ETO), which represses transcription through AML1 (RUNX1) DNA binding sites and immortalizes hematopoietic progenitor cells.	12091906
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Early lymphocyte recovery is a predictive factor for prolonged survival after autologous hematopoietic stem cell transplantation for acute myelogenous leukemia.	12094255
Lymphoma, Non-Hodgkin, Childhood Breast Carcinoma, Multiple Myeloma	Stem Cell Exhaustion	Absolute lymphocyte count (ALC) recovery correlates with survival after autologous hematopoietic stem cell transplantation (AHSCT) for patients with multiple myeloma, non-Hodgkin's lymphoma, and metastatic breast cancer.	12094255
leukemia, Myeloproliferation	Stem Cell Exhaustion	An alternative possibility is that CyA reduces autoimmune-mediated suppression of the underlying stem cell disorder and that the result of this reduction is the manifestation of myeloproliferation and leukemia.	12095153
Hemolysis (biological function)	Stem Cell Exhaustion	The use of peripheral blood stem cells facilitated erythrocyte recovery, regardless of the presence or absence of major ABO-incompatibility, and was associated with a frequent detection of anti-host isohaemagglutin early after minor ABO-incompatible transplantation, which was not associated with clinically relevant haemolysis.	12100136
Malignant Neoplasms	Stem Cell Exhaustion	Continuous complete clinical and molecular remission in two patients with refractory lymphoid malignancies after autografting followed by allogeneic stem cell transplantation with reduced intensity conditioning.	12100137
Lymphoma, Non-Hodgkin, Multiple Myeloma	Stem Cell Exhaustion	We present a 60-year-old patient with primary refractory non-Hodgkin's lymphoma and a 58-year-old patient with multiple myeloma with relapse after first autologous stem cell transplantation (ASCT), who underwent ASCT followed by allogeneic stem cell transplantation (alloSCT) with reduced intensity conditioning consisting of fludarabine and a single dose of total body irradiation.	12100137
Bone marrow stem cell, Tumor necrosis, MYELODYSPLASTIC SYNDROME, Aplastic Anemia	Stem Cell Exhaustion	Hypoplastic myelodysplastic syndromes can be distinguished from acquired aplastic anaemia by bone marrow stem cell expression of the tumour necrosis factor receptor.	12100146
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Flow cytometric analysis revealed that BM stem cells (CD34+) from AA patients have markedly greater TNF receptor (R) 1 and TNFR2 expression than those from patients with MDS and h-MDS.	12100146
Oculomotor Nerve Paralysis, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Unusual presentation of central nervous system relapse with oculomotor nerve palsy in a case of CD56-positive acute myeloid leukemia following allogeneic stem cell transplantation.	12100514
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic stem cell transplantation (allo-SCT) plays an important role in the treatment of infants and children with acute myelogenous leukemia (AML).	12100514
REG1CP gene	Stem Cell Exhaustion	With stem cell factor (SCF) staining, 57% of lesional MCs in RS revealed strong cytoplasmic immunoreactivity, whereas only 9% of MCs were positive in PS.	12100633
Autoimmune Diseases, paraneoplastic pemphigus, Lupus Erythematosus, Aplastic Anemia	Stem Cell Exhaustion	There is growing evidence that immunoablative high-dose cyclophosphamide without stem cell rescue is effective and safe in patients with refractory autoimmune diseases such as paraneoplastic pemphigus, systemic lupus erythematosus, aplastic anemia, and more recently pemphigus vulgaris.	12100688
Autoimmune Diseases	Stem Cell Exhaustion	This case contributes to the growing evidence of high-dose cyclophosphamide's efficacy without stem cell rescue in recalcitrant autoimmune diseases, including pemphigus foliaceus.	12100688
Peripheral Nervous System Diseases, Gammopathy	Stem Cell Exhaustion	Autologous peripheral blood stem cell transplantation for peripheral neuropathy secondary to monoclonal gammopathy of unknown significance.	12105779
Hepatitis B	Stem Cell Exhaustion	Successful antiviral treatment for fulminant reactivated hepatitis B after autologous stem cell transplantation and prophylaxis during subsequent allogeneic stem cell transplantation.	12107567
Chronic Lymphocytic Leukemia, Hepatitis B	Stem Cell Exhaustion	We report the successful therapeutic use of lamivudine and famciclovir for fulminant reactivated hepatitis B after autologous peripheral blood stem cell transplantation (PBSCT) and the subsequent prophylactic use of lamivudine during allogeneic blood stem cell transplantation (alloSCT) for chronic lymphocytic leukemia (CLL) in a 40-year-old patient.	12107567
Small cell carcinoma of lung	Stem Cell Exhaustion	We set out to determine progression-free survival (PFS) and overall long-term survival of ES SCLC and EPSC patients, physiologically aged < or = 60 years, responding to first-line chemotherapy followed by high-dose combination alkylating agents with hematologic stem cell support.	12108918
Lupus Erythematosus, Impaired	Stem Cell Exhaustion	Autologous blood stem cell transplantation in refractory systemic lupus erythematosus with severe pulmonary impairment: a case report.	12115189
Lupus Erythematosus, Autoimmune state, Encephalitis, St. Louis	Stem Cell Exhaustion	For patients with severe forms of autoimmunity, including systemic lupus erythematosus (SLE), purging autoreactive T cells from the immune repertoire by transplanting autologous hematopoietic stem cells (ASCT) is a therapeutic option.	12115189
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	The young DLBCL patients, who have more than two adverse prognostic features, are receiving high-dose chemotherapy and autologous stem cell rescue.	12115338
Chondrosarcoma	Stem Cell Exhaustion	Expression of SOX9 in human chondrosarcomas is novel and suggests that chondrosarcomas originate from a multipotent stem cell committed to differentiation along the chondrogenic pathway.	12115562
Panniculitis, Lupus Erythematosus	Stem Cell Exhaustion	The biopsy findings illustrate that the deep variant of lupus panniculitis may be concentrated around the hair bulbs and deep temporary segments of hair follicles and spare the permanent stem cell-rich follicular segments.	12121404
MEFV gene	Stem Cell Exhaustion	In this patient it is likely that the missing factor in FMF is now being provided by granulocytes derived from the stem cells within transplanted bone marrow.	12130485
Keratitis	Stem Cell Exhaustion	Marginal keratitis associated with administration of filgrastim and sargramostim in a healthy peripheral blood progenitor cell donor.	12131046
Keratitis, Uveitis	Stem Cell Exhaustion	To describe a 61-year-old healthy peripheral blood progenitor cell (PBPC) donor who developed marginal keratitis and mild uveitis on the third day after receiving daily recombinant human granulocyte colony-stimulating factor (rhG-CSF; filgrastim) and recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF; sargramostim) to mobilize PBPCs for allogeneic transplantation.	12131046
fluorodeoxyglucose F18, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Pre-transplant positron emission tomography (PET) using fluorine-18-fluoro-deoxyglucose (FDG) predicts outcome in patients treated with high-dose chemotherapy and autologous stem cell transplantation for non-Hodgkin's lymphoma.	12132049
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	We investigated the predictive value of sequential FDG PET before and after high-dose chemotherapy (HDT) and autologous stem cell transplantation (ASCT) in 24 patients suffering from non-Hodgkin's lymphoma (NHL).	12132049
Communicable Diseases	Stem Cell Exhaustion	Cytomegalovirus (CMV) infection is a significant cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT).	12134098
Hemolysis (biological function)	Stem Cell Exhaustion	[Massive hemolysis following allogeneic peripheral blood stem cell transplantation with minor ABO incompatibility].	12134705
Hemolysis (biological function)	Stem Cell Exhaustion	We observed massive hemolysis after allogeneic peripheral blood stem cell transplantation with minor ABO incompatibility (the donor was group O and the recipient group A).	12134705
Hemolysis (biological function)	Stem Cell Exhaustion	The present case shows that in allogeneic peripheral blood stem cell transplantation with ABO incompatibility, severe hemolysis occurs early after transplantation presumably due to the transfusion of a large number of lymphocytes.	12134705
Infection, Lymphoproliferative Disorders	Stem Cell Exhaustion	CD34+-enriched-CD19+-depleted autologous peripheral blood stem cell transplantation for chronic lymphoproliferative disorders: high purging efficiency but increased risk of severe infections.	12135682
Hematologic Neoplasms	Stem Cell Exhaustion	There were 5,196 admissions to the ICU during this time; 406 (8%) of the patients underwent CPR; 67% had hematologic malignancies or had undergone hematopoietic stem cell transplantation: 256 patients (63%) died at the time of the arrest, and in 150 (37%) spontaneous circulation was restored.	12136227
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	[Clinical analysis of autologous peripheral blood stem cell transplantation in 182 patients with non-Hodgkin's lymphoma].	12137594
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	To evaluate the efficacy of autologous peripheral blood stem cell transplantation (APBSCT) in patients with non-Hodgkin's lymphoma.	12137594
Adult T-Cell Lymphoma/Leukemia, TRPV6 wt Allele	Stem Cell Exhaustion	We describe the case of a 55-year-old man with adult T-cell leukemia/lymphoma (ATL) in first remission who underwent nonmyeloablative allogeneic peripheral blood stem cell transplantation with conditioning consisting of 4 courses of pentostatin and low-dose total body irradiation.	12138903
Agenesis, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Persistent aplasia after chemotherapy for acute myeloid leukaemia treated with stem cell transplantation from a matched unrelated donor after dose-reduced conditioning.	12139730
Palmar-plantar erythrodysesthesia syndrome, Agenesis, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 59-year-old man with acute myeloid leukaemia (AML), was treated after 186 d of chemotherapy-induced persistent aplasia with an allogeneic peripheral blood stem cell transplantation (PBSCT) from a matched unrelated donor (MUD) after dose-reduced conditioning.	12139730
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	As the anti-apoptotic genes Bcl-2 and Bcl-X(L) have been implicated in cell cycle regulation, we investigated the expression of these genes in non-proliferating (Q) and proliferating (P) AML and normal CD34+ progenitor cells.	12139741
Anaplastic carcinoma, Histogenic Process, SERPINB3 wt Allele, Squamous cell carcinoma, Hair follicle structure, F9 wt Allele, Carcinoma	Stem Cell Exhaustion	To further elucidate the histogenesis of carcinomas arising in a PTC, mAbs to hair follicle stem cells and to hair follicle differentiation-specific cytokeratins (mAbs to cytokeratin [CK] 7, CK8, CK18, and CK19 as well as mAbs to CD8/CK15 and CD34) were studied on paraffin-embedded sections of two cases of carcinoma arising in a PTC, one anaplastic carcinoma, and one poorly differentiated squamous cell carcinoma (SCC).	12142616
Blast Phase, Myeloid Leukemia, Chronic, Aspergillosis	Stem Cell Exhaustion	Successful major surgical recovery of a patient following haploidentical stem cell transplantation for chronic myeloid leukemia in blast crisis and aspergillosis.	12145464
Myeloid Leukemia, Chronic, Fever, Aspergillosis, Blast Phase, Leukocytosis	Stem Cell Exhaustion	A 44-year-old woman who underwent haploidentical stem cell transplantation (haplo SCT) for chronic myeloid leukemia in blast crisis and aspergillosis was admitted to the emergency room 7 months later because of severe right upper quadrant abdominal pain, fever, leukocytosis and peritoneal signs.	12145464
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Conditioning with targeted busulfan and cyclophosphamide for hemopoietic stem cell transplantation from related and unrelated donors in patients with myelodysplastic syndrome.	12149198
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	A total of 109 patients (aged 6-66 years; median, 46 years) with myelodysplastic syndrome (MDS) were treated with busulfan (BU) targeted to plasma concentrations of 800 to 900 ng/mL plus cyclophosphamide (CY), 2 x 60 mg/kg, and hemopoietic stem cell (HSC) transplantation from related (n = 45) or unrelated donors (n = 64).	12149198
Mantle cell lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation in patients with mantle cell lymphoma.	12152990
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	High-dose therapy followed by autologous stem cell transplantation (ASCT) has been considered a potential treatment approach in order to improve the poor prognosis in mantle cell lymphoma (MCL), but its role has not yet been clearly established.	12152990
Proteinuria	Stem Cell Exhaustion	Among the other prognostic factors (stage, percentage of bone marrow plasma cells, b2-microglobulin, labeling index, isotype, monoclonal component, Bence-Jones proteinuria) evaluated at diagnosis, there was no clear association with progenitor cell yield.	12161361
Multiple Myeloma	Stem Cell Exhaustion	Oral melphalan at diagnosis hampers adequate collection of peripheral blood progenitor cells in multiple myeloma.	12161361
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Since optimal collection of peripheral blood progenitor cells (PBPC) remains crucial for high-dose therapy in patients with multiple myeloma (MM) in relapse phase or refractory to chemotherapy, we evaluated several variables that may influence mobilization.	12161361
Aleukemic leukemia	Stem Cell Exhaustion	The results showed that both leukemic and non-leukemic stromal cells established with FGF-4, but not with EGF, showed significantly higher progenitor cell-outputs compared with control stromal cells.	12163055
PAFAH1B1 wt Allele	Stem Cell Exhaustion	To date, however, it is still unclear to what extent hematopoietic progenitor cells (HPCs) from AA and MDS share biological properties and what the functional differences are between them.	12163058
PAFAH1B1 wt Allele	Stem Cell Exhaustion	In trying to address this issue, in the present study we have analyzed, in a comparative manner, the proliferation and expansion capacities of bone marrow (BM) progenitor cells from AA and MDS in response to recombinant cytokines.	12163058
PAFAH1B1 wt Allele	Stem Cell Exhaustion	MDS progenitors, on the other hand, are capable to proliferate and expand in response to cytokines; however, their rate of apoptosis is increased by intermediate- and late-acting cytokines, so that the overall proliferation and expansion are significantly lower than those of normal progenitor cells.	12163058
Myxoma of the Endocardium	Stem Cell Exhaustion	These results support the concept that cardiac myxoma might arise from mesenchymal cardiomyocyte progenitor cells.	12163362
PAFAH1B1 wt Allele	Stem Cell Exhaustion	This unique case illustrates heterogeneity of phenotypic expression of a stem cell disorder in MDS and indicates precaution in classifying hematologic syndromes especially when morphology is correlated with specific cytogenetic changes.	12165459
Anemia	Stem Cell Exhaustion	Patients receiving higher doses of IL-10 developed anemia and presented with a dose-dependent increase of ferritin and soluble transferrin receptor levels, an indicator of iron restriction to erythroid progenitor cells.	12165551
Anemia, Inflammatory Bowel Diseases, Inflammation, Hyperferritinaemia	Stem Cell Exhaustion	Our data demonstrate that IL-10 causes anemia in patients with inflammatory bowel disease which may be referred to the induction of imbalances in iron homeostasis by the cytokine, leading to hyperferritinemia and limited iron availability to erythroid progenitor cells, a condition typically seen in the anemia of chronic inflammation.	12165551
hearing impairment	Stem Cell Exhaustion	65/188 (40 %) patients developed hearing impairments after carboplatin containing (1,500 mg/m (2)) high dose chemotherapy with autologous stem cell reinfusion compared to only 33/217 (15 %) in patients receiving platinum free maintenance chemotherapy.	12165893
Toxic effect	Stem Cell Exhaustion	[Unrelated donor stem cell transplantation in children: low toxicity using a GvHD-prophylaxis regimen with CSA, MTX, metronidazole,iv-immunoglobulin and ATG].	12165903
Genetic Diseases, Inborn	Stem Cell Exhaustion	Unrelated donor (UD) hematopoietic stem cell transplantation (HSCT) is accepted as a therapy for leukaemic diseases and varying inborn diseases if a suitable related donor cannot be found.	12165903
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Amifostine promotes hemopoietic progenitor cell mobilization in patients with myelodysplastic syndrome.	12168875
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	The aim of this research was to further evaluate amifostine activity on the hemopoietic progenitor cells of myelodysplastic patients.	12168875
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	We determined amifostine effects on in vitro growth of pre-treatment peripheral blood and bone marrow hemopoietic progenitor cells from myelodysplastic patients, and colony forming unit granulocyte-macrophage and burst forming unit erythroid levels in the peripheral blood of 7 myelodysplastic patients during and following a 3-week treatment with amifostine (200 mg/m2 i.v., three times a week).	12168875
Lymphoma, Non-Hodgkin, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	A case of treatment-related myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemotherapy with autologous stem cell transplantation for non-Hodgkin's lymphoma.	12172056
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	We experienced a 28-yr-old female patient who developed t-MDS/t-AML with characteristic chromosomal abnormalities including 11q23 chromosomal rearrangement following high-dose chemotherapy with autologous stem cell transplantation (ASCT) for non-Hodgkin's lymphoma.	12172056
Neoplasms	Stem Cell Exhaustion	In explanation of the occurrence of satellite tumors and multiple primary tumors, a virus-associated etiology or polyclonality of the tumor or pluripotentiality of tumor stem cells should be considered.	12174935
Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	This paper describes the results of a prospective multicenter study of an intensified purging-free high-dose sequential (i-HDS) chemotherapy schedule with peripheral blood progenitor cell (PBPC) autografting.	12176870
Hematological Disease, Neoplasms, Immune System Diseases	Stem Cell Exhaustion	The Accreditation Sub-Committee of the EBMT regularly publishes special reports on current practice of haemopoietic stem cell transplantation for haematological diseases, solid tumours and immune disorders.	12180107
Graft-vs-Host Disease, Dyspnea, CTCAE	Stem Cell Exhaustion	A 52-year-old male with severe gastrointestinal graft-versus-host disease (GVHD), developed dyspnea and irreversible airflow obstruction, 11 weeks post-allogeneic bone marrow stem cell transplantation.	12180119
B-Cell Lymphomas, Hydrocephalus, Gastrointestinal Hemorrhage	Stem Cell Exhaustion	Unusual cytomegalovirus complications after autologous stem cell transplantation for large B cell lymphoma: massive gastrointestinal hemorrhage followed by a communicating hydrocephalus.	12180120
B-Cell Lymphomas	Stem Cell Exhaustion	Unusual cytomegalovirus (CMV)-related complications were seen after autologous stem cell transplantation (SCT) in a 50-year-old patient with diffuse large B cell lymphoma.	12180120
Multiple Myeloma	Stem Cell Exhaustion	This regimen thus assumes particular significance in developing nations like India, where the majority of patients with myeloma cannot afford the cost of high-dose chemotherapy with stem cell rescue.	12180477
Rheumatoid Arthritis	Stem Cell Exhaustion	High dose chemotherapy and hematopoietic stem cell transplantation: a study of treatment preference in patients with rheumatoid arthritis and rheumatologists.	12180724
Rheumatoid Arthritis	Stem Cell Exhaustion	Patients with intractable rheumatoid arthritis (RA) may benefit from treatment with high dose chemotherapy followed by rescue with autologous hematopoietic peripheral blood stem cell transplant (HSCT).	12180724
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The post-transplant cytogenetic response to interferon is a major determinant of survival after autologous stem cell transplantation for chronic myeloid leukaemia in chronic phase.	12181043
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We have analysed the outcome of 581 autologous stem cell transplants (SCT) for chronic myeloid leukaemia (CML) in first chronic phase reported to the European Group for Blood and Marrow Transplantation between 1983 and 1998.	12181043
Neoplasms, Hematological Disease	Stem Cell Exhaustion	To study mobilisation of peripheral blood stem cells (PBSC) via single and split subcutaneous injection of granulocytic colony-stimulating factor (G-CSF) and isolation of PBSC concentrates for their transplantation with leukapheresis (LA) and large volume leukapheresis (LVL) in patients with solid tumors and hematological diseases as well as in the group of relative donors.	12181830
Hematological Disease, Acquired Immunodeficiency Syndrome	Stem Cell Exhaustion	Haematological disorders (73%) including stem-cell transplantation (36%), solid-organ transplantations (10%) and AIDS (9%) were the main underlying conditions.	12183144
Pregnancy Complications, Infectious, Leukemia, Myelocytic, Acute, Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Infectious complications after autologous hematopoietic stem cell transplantation: comparison of patients with acute myeloid leukemia, malignant lymphoma, and multiple myeloma.	12185506
Hematologic Neoplasms, Pregnancy Complications, Infectious	Stem Cell Exhaustion	It is yet undetermined whether patients with different hematological malignancies have different propensities to infectious complications after high-dose chemotherapy (HDC) and autologous hematopoietic stem cell transplantation (HSCT).	12185506
47, XYY syndrome, Toxic effect	Stem Cell Exhaustion	Severe regimen-related toxicity occurring in a patient with XYY syndrome receiving allogeneic peripheral blood stem cell transplantation.	12185516
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	A 23-year-old man with chronic myelocytic leukemia (CML) in the first chronic phase underwent allogeneic peripheral blood stem cell transplantation (PBSCT) from his HLA-identical sibling.	12185516
Hodgkin Disease, Leukoencephalopathy	Stem Cell Exhaustion	Nonmyeloablative allogeneic stem cell transplantation for refractory Hodgkin's lymphoma complicated by interleukin-2 responsive progressive multifocal leukoencephalopathy.	12185517
Toxic effect	Stem Cell Exhaustion	Nonmyeloablative allogeneic stem cell transplantation (NMASCT) can be used to exploit the graft-versus-tumor (GVT) potential of allogeneic donor cells in the setting of reduced conditioning regimen toxicity.	12185517
Myeloid Leukemia	Stem Cell Exhaustion	Successful reduced-intensity stem cell transplant from one-locus HLA-mismatched unrelated cord blood after rejection of unrelated bone marrow in an infant with myelogenous leukemia.	12186699
Stem Cell Factor	Stem Cell Exhaustion	The levels of thrombopoietin (TPO), interleukin (IL)-11, IL-6, IL-8 and stem cell factor (SCF) were determined by ELISA.	12187073
Kidney Failure, Aplastic Anemia	Stem Cell Exhaustion	Successful allogeneic blood stem cell transplantation for aplastic anemia in a patient with renal insufficiency requiring dialysis.	12189539
Collagen-vascular disease, Hypophosphatasia	Stem Cell Exhaustion	Nonmyeloablative BMT plus mesenchymal stem cells (stromal cells) was effective treatment for a form of collagen-vascular disease and also a lethal form of hypophosphatasia.	12190928
Acute leukemia	Stem Cell Exhaustion	We suggest that MSC can be used effectively for genetically haploidentical haematopoietic stem cell transplantation for acute leukaemia.	12199796
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Treatment of high-risk acute myelogenous leukaemia by myeloablative chemoradiotherapy followed by co-infusion of T cell-depleted haematopoietic stem cells and culture-expanded marrow mesenchymal stem cells from a related donor with one fully mismatched human leucocyte antigen haplotype.	12199796
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 20-year-old woman with high-risk acute myelogenous leukaemia was transplanted with granulocyte colony stimulating factor (G-CSF)-mobilized peripheral blood CD34+ haematopoietic stem cells and bone-marrow-derived mesenchymal stem cells (MSC) from her human leucocyte antigen haplotype-mismatched father after myeloablative conditioning therapy.	12199796
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Evidence for a graft-versus-leukemia effect after allogeneic peripheral blood stem cell transplantation with reduced-intensity conditioning in acute myelogenous leukemia and myelodysplastic syndromes.	12200391
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We report the results of a prospective study of a reduced-intensity conditioning (RIC) regimen followed by allogeneic peripheral blood stem cell transplantation (PBSCT) from an HLA-identical sibling in 37 patients with acute myeloid leukemia (AML; n = 17) or myelodysplastic syndrome (MDS; n = 20).	12200391
Neutropenia, Decreased platelet count	Stem Cell Exhaustion	CD33 antigen is present on normal hematopoietic progenitor cells; thus, an expected high incidence of grade 3 or 4 neutropenia (99%) and thrombocytopenia (99%) was observed.	12200674
Thrombophilia	Stem Cell Exhaustion	Induction of a hypercoagulability state and endothelial cell activation by granulocyte colony-stimulating factor in peripheral blood stem cell donors.	12201956
Hematologic Neoplasms, Malignant neoplasm of ovary, Childhood Breast Carcinoma	Stem Cell Exhaustion	A total of 201 patients with breast cancer, ovarian cancer, or hematological malignancies underwent mobilization of peripheral blood stem cells (PBSC) using chemotherapy and granulocyte-colony stimulating factor (G-CSF).	12201961
Cytomegalovirus Infections	Stem Cell Exhaustion	High-dose acyclovir and pre-emptive ganciclovir to prevent cytomegalovirus disease in myeloablative and non-myeloablative allogeneic stem cell transplantation.	12203140
Cytomegalovirus Infections	Stem Cell Exhaustion	We evaluated high-dose acyclovir and pre-emptive ganciclovir to prevent cytomegalovirus disease in myeloablative and non-myeloablative allogeneic stem cell transplantation.	12203140
Cytomegalovirus Infections	Stem Cell Exhaustion	One hundred and seventy-four consecutive patients who were at risk for CMV infection (either recipient or donor seropositive) and received either intensive chemoradiotherapy and a T cell-depleted stem cell transplant followed by delayed add-back of donor T cells (TCDT: n = 98), or a non-myeloablative preparative regimen followed by an unmanipulated peripheral blood stem cell transplant (NMT: n = 76) from an HLA-identical sibling donor were studied.	12203140
Demyelination	Stem Cell Exhaustion	Adult human white matter progenitor cells can thus disperse widely through regions of experimental demyelination and are able to differentiate as myelinating oligodendrocytes.	12205690
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	Surface proteins tethered to the membrane through a glycosylphosphatidylinositol (GPI) anchor are deficient in the blood cells of patients with paroxysmal nocturnal hemoglobinuria (PNH) as result of a somatic mutation, in a hematopoietic stem cell, of the X-linked phosphatidylinositolglycan complementation group A (PIG-A) gene.	12207345
Critical Illness	Stem Cell Exhaustion	104 critically ill patients after receiving conventional chemotherapy or autologous hematopoietic stem cell transplantation.	12209280
Dermatologic disorders	Stem Cell Exhaustion	Toxic epidermal necrolysis: differential diagnosis of an epidermolytic dermopathy in a hematopoietic stem cell transplant recipient.	12209357
Aplastic Anemia	Stem Cell Exhaustion	A 35-year-old woman underwent allogeneic hematopoietic stem cell transplantation (HSCT) for severe aplastic anemia (SAA).	12209357
melanoma	Stem Cell Exhaustion	In vitro and in vivo characterization of graft-versus-tumor responses in melanoma patients after allogeneic peripheral blood stem cell transplantation.	12209588
Hematologic Neoplasms, Neoplasms, Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	It has been shown that after allogeneic peripheral blood stem cell transplantation (PBSCT), donor T cells can induce potent graft-versus-tumor (GVT) effects in hematologic malignancies and possibly solid tumors such as renal cell carcinoma.	12209588
Neoplasms	Stem Cell Exhaustion	This enzyme is activated in germ and stem cells, repressed in normal somatic cells and reactivated in a large majority of tumor cells.	12209957
Lymphoma, Non-Hodgkin, Transfusion-Related Acute Lung Injury, Purpura, Thrombotic Thrombocytopenic	Stem Cell Exhaustion	We describe a mild case of TRALI during plasma exchange for thrombotic thrombocytopenic purpura in a 56-year-old woman, status post autologous hematopoietic stem cell transplant for non-Hodgkin's lymphoma.	12210713
Osteopenia/osteoporosis, Type 2, senile	Stem Cell Exhaustion	In this study, we demonstrate in murine models for both type I (estrogen deficiency) and type II (senile) osteopenia/osteoporosis that reduced bone formation is related to a decrease in adult mesenchymal stem cell (AMSC) number, osteogenic activity, and proliferation.	12210753
malignant disease, Fever, Pregnancy Complications, Infectious	Stem Cell Exhaustion	Risk of neutropenic fever and early infectious complications after autologous peripheral blood stem cell transplantation for malignant diseases.	12215019
Malignant Neoplasms	Stem Cell Exhaustion	Autologous peripheral blood stem cell transplantation (auto-PBSCT) has facilitated high-dose chemotherapy for the treatment of various types of malignancy, but the factors affecting the treatment outcome have not been well defined.	12215019
Chronic Lymphocytic Leukemia, Fan Device, Communicable Diseases	Stem Cell Exhaustion	FAND associated with extensive infection prophylaxis and G-CSF support is a highly cytoreductive and well-tolerated treatment for CLL patients and in most cases does not hamper subsequent stem cell mobilization.	12217804
Hematologic Neoplasms	Stem Cell Exhaustion	The population of elderly patients with hematologic malignancies is increasing and so will the activity of stem cell transplantation (SCT) in this population.	12217809
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Feasibility of peripheral blood progenitor cell mobilization and harvest to support chemotherapy intensification in elderly patients with poor prognosis: non-Hodgkin's lymphoma.	12224002
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Mobilized peripheral blood progenitor cells (PBPC) are widely employed in the management of adult patients with high-risk non-Hodgkin's lymphoma (NHL), though their use in the elderly has received little attention.	12224002
Disseminated Intravascular Coagulation	Stem Cell Exhaustion	The conditioning regimen preceding hematopoietic stem cell transplantation (HSCT) causes a rapid decrease in the platelet count and signs of disseminated intravascular coagulation, possibly indicating platelet activation.	12224003
Aggressive course	Stem Cell Exhaustion	Aggressive NHL should be cured by first-line chemotherapy with or without hematopoietic stem cell transplantation.	12225393
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	[Chronic myelogenous leukemia treated with non-myeloablative stem cell transplantation after discontinuing myeloablative stem cell transplantation due to mental aberrations].	12229128
Hematologic Neoplasms, Mental disorders	Stem Cell Exhaustion	We think that non-myeloablative stem cell transplantation is a useful treatment for patients with hematological malignancy complicated with psychiatric disorders.	12229128
Hematological Disease	Stem Cell Exhaustion	Phase II study of a moderate-intensity preparative regimen with allogeneic peripheral blood stem cell transplantation for hematologic diseases: the Texas Transplant Consortium experience.	12234167
Toxic effect	Stem Cell Exhaustion	Conventional preparative regimens for allogeneic stem cell transplantation are associated with excessive regimen-related toxicity (RRT) in some patients because of underlying comorbidities, advanced age, or prior treatment.	12234167
Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	Performance of a hybrid central venous catheter utilized for both peripheral blood stem cell harvest and transplant support of patients undergoing autologous peripheral blood stem cell transplantation.	12235524
beta Thalassemia	Stem Cell Exhaustion	Full chimerism in nonmyeloablative stem cell transplantation in a beta-thalassemia major patient (class 3 Lucarelli).	12235528
Aplastic Anemia	Stem Cell Exhaustion	Successful treatment of pure red cell aplasia with a single dose of rituximab in a child after major ABO incompatible peripheral blood allogeneic stem cell transplantation for acquired aplastic anemia.	12235527
Pure Red-Cell Aplasia, Aplastic Anemia	Stem Cell Exhaustion	We report a 10-year-old boy with post-hepatitis aplastic anemia (AA) who developed PRCA after HLA-matched familial peripheral blood stem cell transplantation (SCT) following conditioning with Cph 200 mg/kg + ATG 90 mg/kg.	12235527
Neutropenia	Stem Cell Exhaustion	Patients who had been treated with chemotherapy or stem-cell transplantation were randomized to receive acyclovir 400 mg orally 3 times daily (n = 51), valacyclovir 500 mg orally twice daily (n = 48), or valacyclovir 250 mg orally twice daily (n = 52) during neutropenia.	12243600
Hallopeau-Siemens Disease	Stem Cell Exhaustion	phi C31 integrase-based gene transfer stably integrated the COL7A1 cDNA into genomes of primary epidermal progenitor cells from four unrelated RDEB patients.	12244305
Graft-vs-Host Disease	Stem Cell Exhaustion	Peripheral blood stem cell transplantation and graft-versus-host disease: a case study.	12244530
Hematologic Neoplasms	Stem Cell Exhaustion	Peripheral blood stem cell transplantation is an acceptable treatment option for children with hematologic malignancies that are refractory to traditional treatments.	12244530
Graft-vs-Host Disease	Stem Cell Exhaustion	Reports in the literature suggest that acute graft-verus-host disease (aGVHD), a common complication of peripheral blood stem cell transplantation, is associated with significant morbidity and mortality.	12244530
Malignant Neoplasms	Stem Cell Exhaustion	This article reports on a 3-year-old child with a hematologic malignancy who, upon relapse, had received an identically matched allogeneic stem cell transplant from a sibling.	12244530
Cardiotoxicity, Troponin T, Cardiac Muscle, Hematologic Neoplasms	Stem Cell Exhaustion	We prospectively evaluated the potential cardiotoxic effects of conditioning with fractionated total body irradiation and high-dose cyclophosphamide (TBI/CY) by serial measurement of serum cardiac troponin T (cTnT), assessment of systolic and diastolic echocardiographic parameters and analysis of ventricular repolarisation indices (QT-dispersion and corrected QT-dispersion) in 30 adult patients with haematological malignancies undergoing haematopoietic stem cell transplantation.	12270055
Enteropathy-Associated T-Cell Lymphoma	Stem Cell Exhaustion	CD56 positive intestinal T-cell lymphoma: treatment with high dose chemotherapy and autologous peripheral blood stem cell transplantation.	12322803
Colonic Stenosis, Amyloidosis	Stem Cell Exhaustion	Primary systemic amyloidosis presenting as a colonic stricture: successful treatment with left hemicolectomy followed by autologous hematopoietic stem-cell transplantation: report of a case.	12352247
Aplastic Anemia	Stem Cell Exhaustion	Non-myeloablative haematopoietic stem cell transplantation for severe aplastic anaemia with various complications.	12358892
Aplastic Anemia	Stem Cell Exhaustion	We report a 20-year-old-male with severe aplastic anaemia who was treated with nonmyeloablative haematopoietic stem cell transplantation (NSCT) from a sibling donor.	12358892
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Allogeneic stem cell transplantation in the myelodysplastic syndromes: interim results of outcome following reduced-intensity conditioning compared with standard preparative regimens.	12358919
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Conventional allogeneic stem cell transplantation (SCT) for myelodysplastic syndrome (MDS) is associated with excessive procedure-related mortality.	12358919
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	High-dose infusional ifosfamide, etoposide plus methylprednisolone followed by dexamethasone, high-dose ara-C and cisplatinum and autologous stem cell transplantation for refractory or relapsed aggressive non-Hodgkin's lymphoma.	12368156
Multiple Myeloma	Stem Cell Exhaustion	A combination of dexamethasone, cyclophosphamide, etoposide, and cisplatin is less toxic and more effective than high-dose cyclophosphamide for peripheral stem cell mobilization in multiple myeloma.	12368158
Toxic effect, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The purpose of this study was to compare the efficacy and toxicity of two regimens for peripheral blood stem cell (PBSC) mobilization in multiple myeloma (MM) patients.	12368158
Stem Cell Factor	Stem Cell Exhaustion	In this study, we stained the stem cell factor (SCF) and the Kit receptor in tryptase-positive mast cells, since these molecules are essential for mast cell survival, growth, migration and activation.	12373338
Fournier Gangrene	Stem Cell Exhaustion	Fournier's gangrene after unrelated cord blood stem cell transplantation.	12373358
Fournier Gangrene, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 16-year-old boy with refractory acute myelogenous leukemia developed Fournier's gangrene as an early complication after two-antigen HLA-mismatched unrelated cord blood stem cell transplantation.	12373358
Up, Malignant Neoplasms	Stem Cell Exhaustion	Thirty-six patients (51%) had high-risk malignancy, 28 (40%) had unrelated or genotypically mismatched related donors (alternate donors [AD]) and 29 (41%) received bone marrow rather than blood as stem cell source.	12374451
Hematological Disease	Stem Cell Exhaustion	Evaluation of safety and pharmacokinetics of administering intravenous busulfan in a twice-daily or daily schedule to patients with advanced hematologic malignant disease undergoing stem cell transplantation.	12374453
Lymphoproliferative Disorders	Stem Cell Exhaustion	Malignant cells may contribute to relapse after autologous hematopoietic cell transplantation The effectiveness of a double immunomagnetic purging strategy combining CD34-positive with B-negative cell selection to purge peripheral blood progenitor cells (PBPCs) from patients with chronic lymphoproliferative disorders has been analyzed.	12375665
Liver carcinoma, Liver regeneration disorder, Cholangiocarcinoma	Stem Cell Exhaustion	The c-kit-positive hepatic progenitor cells were singly scattered between hepatocytes, and their number was highest in cirrhotic nodule and decreased in dysplastic nodule, whereas they were absent in cholangiocarcinoma and hepatocellular carcinoma arising in dysplastic nodules.	12379757
Liver carcinoma, Hepatocarcinogenesis, Cholangiocarcinoma	Stem Cell Exhaustion	These observations indicate that cholangiocarcinoma as well as hepatocellular carcinoma can develop in dysplastic nodule and that hepatic progenitor cells might play a role in the early stage of cholangiocarcinogenesis and hepatocarcinogenesis.	12379757
Cytomegalovirus Infections	Stem Cell Exhaustion	These results suggest that the amount of immature glial cells, which include neural progenitor cells, in the developing brain or in the damaged brain with neural proliferation may be closely associated with the susceptibility of the brain to CMV infection in humans.	12379769
Multiple Myeloma	Stem Cell Exhaustion	Collection of peripheral blood stem cells in newly diagnosed myeloma patients without any prior cytoreductive therapy: the first step towards an 'operational cure'?	12379885
Multiple Myeloma	Stem Cell Exhaustion	We conclude that it is possible to harvest stem cells in three-quarters of untreated myeloma patients.	12379885
Clostridium difficile infection, Diarrhea	Stem Cell Exhaustion	Rarity of toxigenic Clostridium difficile infections after hematopoietic stem cell transplantation: implications for symptomatic management of diarrhea.	12379891
Diarrhea	Stem Cell Exhaustion	Diarrhea is a common complication of high-dose chemotherapy and hematopoietic stem cell transplantation (HSCT).	12379891
Rheumatoid Arthritis	Stem Cell Exhaustion	Development of rheumatoid arthritis following autologous peripheral blood stem cell transplantation.	12379893
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	A 51-year-old man with non-Hodgkin's lymphoma (NHL) was treated with high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation (PBSCT).	12379893
Small cell carcinoma of lung	Stem Cell Exhaustion	Early tandem high-dose ifosfamide, carboplatin, etoposide therapy with stem cell rescue for small-cell lung cancer: brief report on the results of a phase-I/II trial.	12381904
Toxic effect	Stem Cell Exhaustion	The toxicity and efficacy of donor lymphocyte infusions given after reduced-intensity conditioning allogeneic stem cell transplantation.	12384406
LIPG gene	Stem Cell Exhaustion	The value of hematopoietic stem cell transplantation (HSCT) for EL is unknown.	12384410
Thrombocytosis, Polycythemia Vera	Stem Cell Exhaustion	Curative therapy of advanced essential thrombocythemia or polycythemia vera by hemopoietic stem cell transplantation.	12389621
Thrombocytosis, Polycythemia Vera, Fred Hutchinson/University of Washington Cancer Consortium	Stem Cell Exhaustion	Twenty-five patients with advanced essential thrombocythemia (ET; n = 13) or polycythemia vera (PV; n = 12) received hemopoietic stem cell transplants (HSCT) at the Fred Hutchinson Cancer Research Center.	12389621
Communicable Diseases	Stem Cell Exhaustion	Cytomegalovirus (CMV) infection causes significant morbidity and mortality in the setting of immunodeficiency, including the immune reconstitution phase following allogeneic stem cell transplantation (SCT).	12393402
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Outcomes of highly purified CD34(+) peripheral blood stem cell transplantation (PBSCT) for chronic phase chronic myeloid leukemia (CML) (n = 32) were compared with those of PBSCT (n = 19) and of bone marrow transplantation (BMT) (n = 22) in the HLA-compatible sibling donor setting.	12393406
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Outcome of transplantation of highly purified peripheral blood CD34+ cells with T-cell add-back compared with unmanipulated bone marrow or peripheral blood stem cells from HLA-identical sibling donors in patients with first chronic phase chronic myeloid leukemia.	12393406
Aspergillosis	Stem Cell Exhaustion	Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors.	12393425
Aspergillosis	Stem Cell Exhaustion	The incidence of postengraftment invasive aspergillosis (IA) in hematopoietic stem cell transplant (HSCT) recipients increased during the 1990s.	12393425
Graft-vs-Host Disease, Viral respiratory infection, Neutropenia	Stem Cell Exhaustion	Risk factors included host variables (age, underlying disease), transplant variables (stem cell source), and late complications (acute and chronic graft-versus-host disease [GVHD], receipt of corticosteroids, secondary neutropenia, cytomegalovirus [CMV] disease, and respiratory virus infection).	12393425
Cytomegalovirus Infections, Neutropenia, Lymphopenia, Respiratory Tract Infections, Graft-vs-Host Disease	Stem Cell Exhaustion	Factors that increased risks for IA after engraftment included receipt of T cell-depleted or CD34-selected stem cell products, receipt of corticosteroids, neutropenia, lymphopenia, GVHD, CMV disease, and respiratory virus infections.	12393425
PAFAH1B1 wt Allele	Stem Cell Exhaustion	The present data demonstrate that almost 50% of erythroid progenitor cells derived from patients with MDS exhibit spontaneous release of cytochrome c from mitochondria with ensuing activation of caspase-9, whereas normal erythroid progenitors display neither of these features.	12393561
Cessation of life, PAFAH1B1 wt Allele	Stem Cell Exhaustion	We propose that the increased sensitivity of MDS progenitor cells to death receptor stimulation is due to a constitutive activation of the mitochondrial axis of the apoptotic signaling pathway in these cells.	12393561
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Nonmyeloablative allogeneic stem cell transplantation for the treatment of chronic myeloid leukemia in first chronic phase.	12393604
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	NST may successfully replace myeloablative stem cell transplantation, providing a safer, well-tolerated therapeutic option for all patients with CML in first CP with a matched donor.	12393604
Lymphoma	Stem Cell Exhaustion	Treatment for patients with stage IV indolent lymphoma ranges from watchful waiting to intensive chemotherapy and stem cell transplantation.	12393618
Aggressive Non-Hodgkin Lymphoma, Lymphoma	Stem Cell Exhaustion	Chemoresistant or aggressive lymphoma predicts for a poor outcome following reduced-intensity allogeneic progenitor cell transplantation: an analysis from the Lymphoma Working Party of the European Group for Blood and Bone Marrow Transplantation.	12393626
Lymphoma	Stem Cell Exhaustion	We report the outcome of reduced-intensity allogeneic progenitor cell transplantation (alloPCT) for 188 patients with lymphoma from the Working Party Lymphoma of the European Group for Blood and Bone Marrow Transplantation (EBMT).	12393626
Lymphoma, Non-Hodgkin, Familial, HD Term Type	Stem Cell Exhaustion	Reduced-intensity progenitor cell transplantation is associated with a reduced TRM and may control advanced HD and low-grade NHL.	12393626
PAFAH1B1 wt Allele	Stem Cell Exhaustion	MDS EBCs often coexpressed stem cell antigens and late-stage myeloid antigens asynchronously, but rarely expressed T- and B-lymphoid cell-specific antigens.	12393641
Bone marrow stem cell, Adenoviruses	Stem Cell Exhaustion	Cidofovir (CDV), a broad spectrum anti-DNA viral agent, has previously been shown to be of therapeutic benefit in life-threatening adenoviral disease in bone marrow stem-cell recipients.	12394854
Carcinoid Tumor	Stem Cell Exhaustion	Carcinoid tumours arise from argentaffine cells or from a primitive stem cells which may differentiate into anyone of a variety of adult endocrine-secreting cells.	12395445
Neoplasms, Endocrine Gland Neoplasms	Stem Cell Exhaustion	These duct-endocrine cell tumors or duct-acinar- endocrine cell tumors of the pancreas may be derived from a stem cell that retains the capability of expressing either an exocrine or endocrine phenotype.	12395898
leukemia	Stem Cell Exhaustion	In the treatment of leukemia by stem cell transplantation, the immunological effects of allogeneic T-lymphocytes presumably play a greater part than high-dosage total-body irradiation (TBI) and chemotherapy.	12397547
Anemia, Rheumatoid Arthritis	Stem Cell Exhaustion	Inhibition of erythroid progenitor cells due to MIP-1alpha or other cytokines can play a role in the pathogenesis of anemia which is one of the most common extra-articular features of active rheumatoid arthritis (RA).	12399885
PAFAH1B1 wt Allele, Hematological Disease, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is a clonal disorder of hematopoietic stem cells.	12399970
Cytomegalovirus Infections, Immunocompromised Host	Stem Cell Exhaustion	CMV infection is usually observed in immunocompromised patients but some cases have been recently observed in patients after autologous stem-cell transplantation with or without CD34 + stem-cell selection.	12400617
Toxic nephropathy	Stem Cell Exhaustion	Cumulative prior dose of cisplatin as a cause of the nephrotoxicity of high-dose chemotherapy followed by autologous stem-cell transplantation.	12401849
malignant disease, Toxic nephropathy	Stem Cell Exhaustion	Nephrotoxicity is one of the most frequent dose-limiting factors of high-dose chemotherapy to create tolerance of autologous peripheral blood stem-cell transplantation (PBSCT) for the treatment of malignant diseases.	12401849
Prostate carcinoma	Stem Cell Exhaustion	Prostate stem cell antigen: Identification of immunogenic peptides and assessment of reactive CD8+ T cells in prostate cancer patients.	12402309
Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	The patient underwent 2 courses of combination chemotherapy CHOP (consisting of cyclophosphamide, doxorubichin, vincristine, and prednisolone), and high-dose chemotherapy (ranimustine, etoposide, ifosfamide) with peripheral blood stem cell transplantation.	12402484
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	In basal conditions, committed and immature progenitor cells were found decreased in myelodysplastic (MDS) patients.	12404285
Delirium	Stem Cell Exhaustion	Delirium in patients undergoing hematopoietic stem cell transplantation.	12404292
Delirium	Stem Cell Exhaustion	Studies have not examined the epidemiology of delirium in patients undergoing hematopoietic stem cell transplantation (HSCT).	12404292
Viremia	Stem Cell Exhaustion	Donor CMV serostatus has no impact on CMV viremia or disease when prophylactic granulocyte transfusions are given following allogeneic peripheral blood stem cell transplantation.	12406871
Viremia	Stem Cell Exhaustion	We studied the impact of donor cytomegalovirus (CMV) serologic status on CMV viremia and disease when prophylactic granulocyte colony-stimulating factor (G-CSF)-mobilized granulocyte transfusions (GTs) were given following allogeneic peripheral blood stem cell (AlloPBSC) transplantation.	12406871
Childhood Non-Hodgkin Lymphoma, Multiple Myeloma, Lymphoma, Non-Hodgkin, Familial, Morular Metaplasia of the Endometrium, Axin Signaling Complex	Stem Cell Exhaustion	Changes in blood dendritic cell (BDC) counts (CD123(hi)BDC and CD11c(+)BDC) and expression of CD62L, CCR7, and CD49d were analyzed in healthy donors, multiple myeloma (MM), and non-Hodgkin lymphoma (NHL) patients, who received granulocyte-colony stimulating factor (G-CSF) containing peripheral blood stem cell (PBSC) mobilization protocols.	12406901
Blast Phase, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Sustained molecular remission in a patient with CML in blastic crisis receiving dose-reduced hematopoietic stem-cell transplantation followed by early withdrawal of cyclosporine and prophylactic use of interferon-alpha.	12410575
Multiple Myeloma	Stem Cell Exhaustion	27 months after donating progenitor cells, a diagnosis of multiple myeloma was made in a 6/6 HLA-phenotypically matched unrelated donor.	12410583
leukemia	Stem Cell Exhaustion	BU-CTX(2) as conditioning regimen for allogeneic hematopoietic stem cell transplantation in sixty patients with leukemia.	12411050
leukemia	Stem Cell Exhaustion	To evaluate the long-term outcome of 60 leukemia patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) prepared with busulphan-cyclophosphamide (BU-CTX(2)) conditioning regimen.	12411050
Acute lymphocytic leukemia, Myeloid Leukemia, Chronic, leukemia, Leukemia, Myelocytic, Acute, BCR gene	Stem Cell Exhaustion	From April 1994 to August 2000, 60 leukemia patients (35 male, 25 female; median age 32 years old), including 20 acute myeloid leukemia (AML, CR(1) n = 19, CR(2) n = 1), 15 acute lymphocytic leukemia (ALL, CR(1) n = 8, CR(2) n = 6, CR(3) n = 1), and 25 chronic myeloid leukemia (CML, CP(1) n = 24, CP(2) n = 1) received allogeneic hematopoietic stem cells from HLA-identical siblings (n = 53), 1-locus mismatched siblings (n = 4), or HLA-identical unrelated donor (n = 3).	12411050
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Furthermore, this study provides evidence that in MDS, hematopoietic stem cells accumulate defects that prevent normal hematopoiesis.	12411319
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	In conclusion, our findings suggest that PNH clones might contribute qualitatively and quantitatively differentially to specific blood cell lineages during differentiation and maturation of hematopoietic stem cells.	12411324
Multiple Myeloma	Stem Cell Exhaustion	Feasibility of a mixed inpatient-outpatient model of peripheral blood stem cell transplantation for multiple myeloma.	12414350
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	A progressively growing number of peripheral blood stem cell transplants (PBSCTs) are being performed in patients with newly diagnosed multiple myeloma (MM) since they are ever more frequently being offered as up-front therapy.	12414350
Heart failure, Hematological Disease	Stem Cell Exhaustion	Forty months after the outbreak, five patients are alive (one after autologous and one after allogeneic stem cell transplantation), while eight have died, seven of hematologic disease, and one of cardiac failure.	12414351
Hepatitis C, Hematological Disease	Stem Cell Exhaustion	As regards the impact of HCV infection on the outcome of the hematologic diseases, changes in the scheduled therapy, including stem cell transplantation, were not required.	12414351
Limbal stem cell deficiency	Stem Cell Exhaustion	To describe and to characterize the clinical findings and prognosis of patients with idiopathic limbal stem cell deficiency (LSCD).	12414406
Damage	Stem Cell Exhaustion	Long-lasting bone damage detected by dual-energy x-ray absorptiometry, phalangeal osteosonogrammetry, and in vitro growth of marrow stromal cells after allogeneic stem cell transplantation.	12414872
Fracture, Bone necrosis, Osteoporosis	Stem Cell Exhaustion	Bone complications after allogeneic stem cell transplant (allo-SCT) include osteoporosis, fractures, and osteonecrosis.	12414872
Colorectal Carcinoma, Adenomatous Polyps	Stem Cell Exhaustion	The incidence of colorectal cancers in the Surveillance, Epidemiology, and End Results registry is most consistent with a model positing two rare events followed by a high-frequency event in the conversion of a normal stem cell into an initiated cell that expands clonally to give rise to an adenomatous polyp.	12415112
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Rituximab for aggressive non-Hodgkin's lymphomas relapsing after or refractory to autologous stem cell transplantation.	12416894
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	The median survival for aggressive non-Hodgkin's lymphomas relapsing after or refractory to high-dose therapy and autologous stem cell transplantation therapy is 6.2 months.	12416894
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Between January 1997 and February 2000, we treated 17 patients with aggressive non-Hodgkin's lymphomas whose disease was refractory to, or relapsed after, autologous stem cell transplantation.	12416894
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Rituximab is effective and well-tolerated palliative treatment for aggressive non-Hodgkin's lymphomas that relapse after or is refractory to autologous stem cell transplantation.	12416894
Toxic effect	Stem Cell Exhaustion	According to recent reports, fast engraftment with minimal transplant-related toxicity and mortality (TRT, TRM) can be achieved by using reduced-intensity preparative regimens in allogeneic hematopoietic stem cell transplantation (HSCT).	12420203
leukemia	Stem Cell Exhaustion	Long-term follow-up of normal peripheral blood progenitor cell donors treated with filgrastim: no evidence of increased risk of leukemia development.	12420204
Palmar-plantar erythrodysesthesia syndrome	Stem Cell Exhaustion	Predictive value of circulating immature cell counts in peripheral blood for timing of peripheral blood progenitor cell collection after G-CSF plus chemotherapy-induced mobilization.	12421227
Hemolysis (biological function)	Stem Cell Exhaustion	Severe immune hemolysis after minor ABO-mismatched allogeneic peripheral blood progenitor cell transplantation occurs more frequently after nonmyeloablative than myeloablative conditioning.	12423513
Hemolysis (biological function)	Stem Cell Exhaustion	Hemolysis as a result of donor-recipient minor ABO mismatching is a complication of allogeneic peripheral blood progenitor cell (PBPC) transplantation (PBPCT).	12423513
Toxic effect	Stem Cell Exhaustion	Reliable engraftment, low toxicity, and durable remissions following allogeneic blood stem cell transplantation with minimal conditioning.	12423689
Hematologic Neoplasms	Stem Cell Exhaustion	Allogeneic blood stem cell transplantation (BSCT) can cure patients with hematologic malignancies by high-dose chemotherapy and allogeneic graft-vs-tumor (GvT) reactions.	12423689
Lymphoma, Multiple Myeloma, Myeloid Leukemia, Chronic, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Thirty-four patients with lymphoma (11), myeloma (10), chronic myeloid leukemia (4), myelodysplastic syndrome (5), and acute myeloid leukemia (4) were treated with fludarabine (3 x 30 mg/m(2)) and 200 cGy total-body irradiation followed by the infusion of peripheral blood stem cells from related (28) or unrelated (6) donors.	12423689
Aplastic Anemia	Stem Cell Exhaustion	Immune-mediated inhibition of hematopoiesis has been suspected as a major cause of the suppressed growth of progenitor cells in aplastic anemia (AA).	12424537
Peripheral T-Cell Lymphoma, Hepatosplenomegaly	Stem Cell Exhaustion	High-dose chemotherapy and autologous peripheral blood stem cell transplantation for treatment of unspecified peripheral T-cell lymphoma presented with hepatosplenomegaly and hypercytokinemia syndrome: report of three cases.	12424541
Peripheral T-Cell Lymphoma, Hepatosplenomegaly, Infiltration	Stem Cell Exhaustion	We report here three cases of peripheral T-cell lymphoma unspecified (PTCL-US), which presented with bone marrow infiltration and hepatosplenomegaly and were successfully treated with high-dose chemotherapy (HDCT) and autologous peripheral blood stem cell transplantation (auto-PBSCT).	12424541
Aspergillus ustus, Aspergillosis	Stem Cell Exhaustion	Primary cutaneous aspergillosis caused by Aspergillus ustus following reduced-intensity stem cell transplantation.	12424542
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	A 19-year-old woman with myelodysplastic syndrome underwent reduced-intensity stem cell transplantation [RIST: (cladribine 0.11 mg/kg for 6 days, busulfan 4 mg/kg for 2 days, and rabbit antithymocyte globulin)] from her one HLA-mismatched mother.	12424542
Hematologic Neoplasms	Stem Cell Exhaustion	Interleukin 12 immunotherapy after autologous stem cell transplantation for hematological malignancies.	12429625
Specialty Type - cancer	Stem Cell Exhaustion	To determine the safety, maximum tolerated dose,and biological effects of recombinant human IL-12 after autologous stem cell transplantation for cancer.	12429625
Hematologic Neoplasms	Stem Cell Exhaustion	Biologically active doses of IL-12 can be given safely to patients after autologous stem cell transplantation for high-risk hematological malignancies.	12429625
Pancreatic carcinoma	Stem Cell Exhaustion	The stem cell factor-c-kit system and mast cells in human pancreatic cancer.	12429808
Malignant Neoplasms	Stem Cell Exhaustion	Stem cell factor (SCF) and its receptor c-kit take part in the regulation of developmental processes of mast cells, hematopoietic stem cells, and melanocytes, as well as in the growth control of human malignancies.	12429808
malignant disease	Stem Cell Exhaustion	Related and unrelated nonmyeloablative hematopoietic stem cell transplantation for malignant diseases.	12430851
Hematologic Neoplasms	Stem Cell Exhaustion	Patients with advanced hematological malignancies ineligible for conventional myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) due to advanced age or medical contraindications were enrolled in multi-center study to investigate the safety and efficacy of nonmyeloablative HSCT using a 2 Gy total body irradi ation (TBI)-based regimen.	12430851
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Autologous stem-cell transplantation for patients with acute myeloid leukemia aged over 60 yr.	12431238
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Preliminary reports have suggested that autologous stem-cell transplantation (ASCT) is feasible in elderly patients with acute myeloid leukemia (AML).	12431238
Aggressive Non-Hodgkin Lymphoma, Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	Many cost analyses of stem-cell transplantations are available, which is in sharp contrast to the level of cost analyses on first-line chemotherapy for aggressive non-Hodgkin's lymphoma (NHL).	12431240
Lupus Erythematosus	Stem Cell Exhaustion	[Transplantation of purified CD34+ stem cells from autologous peripheral blood for treatment of systemic lupus erythematosus].	12433652
Lupus Erythematosus, Encephalitis, St. Louis	Stem Cell Exhaustion	We used the transplantation of purified autologous peripheral blood CD34+ stem cells to treat a 16-year-old female patient with systemic lupus erythematosus (SLE), who had received unsuccessful treatment with steroids and immunosuppressants, and has achieved satisfactory therapeutic effect.	12433652
Graft-vs-Host Disease, Stable chronic Graft vs Host Disease	Stem Cell Exhaustion	Graft-versus-host disease in its acute (aGvHD) or chronic form (cGvHD) remains the most important posttransplantation factor influencing outcome after allogeneic hematopoietic stem cell transplantation (HSCT).	12433695
Leukemia, Myelocytic, Acute, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Evidence from allogeneic hematopoietic stem cell transplantation indicates a possible immune response against leukemia-associated antigens in patients with either acute myeloid leukemia (AML) or chronic myeloid leukemia (CML).	12434951
Hemorrhage	Stem Cell Exhaustion	A prospective randomized trial of prophylactic platelet transfusion and bleeding incidence in hematopoietic stem cell transplant recipients: 10,000/L versus 20,000/microL trigger.	12434952
B-Cell Lymphomas	Stem Cell Exhaustion	Treatment with the anti-CD20 antibody rituximab prior to stem cell collection may lead to tumor-free stem cell collections in patients with B-cell lymphoma undergoing autologous stem cell transplantation.	12435284
Lymphoma	Stem Cell Exhaustion	To test the feasibility of obtaining polymerase chain reaction (PCR)-negative stem cell collection, 30 patients with a variety of B-cell lymphomas were enrolled in a protocol employing a common MINE (mitoxantrone/ifosfamide/etoposide) salvage regimen with rituximab (in vivo purging).	12435284
Hemolysis (biological function)	Stem Cell Exhaustion	We hypothesized that patients undergoing major ABO-incompatible non-myeloablative haematopoietic stem cell transplantation (nm-HSCT) might experience prolonged haemolysis after transplant due to the delayed disappearance of host plasma cells producing anti-donor isohaemagglutinins (HAs).	12437653
Graft-vs-Host Disease	Stem Cell Exhaustion	The association between various human leucocyte antigen (HLA) alleles and the occurrence of acute and chronic graft-versus-host disease (GVHD) was evaluated in 493 haematopoietic stem-cell transplant (HSCT) patients with HLA identical sibling donors.	12437654
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Treatment of secondary myelodysplastic syndrome after heart transplantation with chemotherapy and nonmyeloablative stem-cell transplantation.	12438973
Hematologic Neoplasms	Stem Cell Exhaustion	Allogeneic blood stem-cell transplantation using minimal conditioning is a new, promising treatment option for patients with hematologic malignancies after solid-organ transplantation.	12438973
Central neuroblastoma	Stem Cell Exhaustion	Patients with high-risk neuroblastoma who have multiple copies of MYCN fare much worse than do those without MYCN amplification; however, it has not been clarified whether intensified chemotherapy with or without blood stem cell transplantation can alter the extremely poor prognosis of patients with amplified MYCN.	12439032
Damage, Multiple Myeloma	Stem Cell Exhaustion	Amifostine reduces mucosal damage after high-dose melphalan conditioning and autologous peripheral blood progenitor cell transplantation for patients with multiple myeloma.	12439700
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Successful non-T cell-depleted HLA haplo-identical three-loci mismatched hematopoietic stem cell transplantation from mother to son based on the feto-maternal microchimerism in chronic myelogenous leukemia.	12439703
Blast Phase, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	A 17-year-old male with chronic myelogenous leukemia in blast crisis received a non-T cell-depleted (TCD) HLA haplo-identical three-loci mismatched hematopoietic stem cell transplant (HSCT) from his mother.	12439703
Histogenic Process, Neoplasms	Stem Cell Exhaustion	The histogenesis of this tumor may be associated with a totipotent stem cell of esophageal mucosa, which has the potential to differentiate into squamous cells, ductal cells or myoepithelial cells.	12445139
BONE MARROW FAILURE SYNDROME 1	Stem Cell Exhaustion	Modest changes in mutation numbers and mitochondrial microsatellites may be evidence of increased mutagenesis in mtDNA, or, more likely, a reflection of limited clonality among hematopoietic stem cells in this bone marrow failure syndrome.	12446454
Colon Carcinoma, Neoplasms	Stem Cell Exhaustion	Colon carcinoma with multidirectional differentiation is a rare event and may originate from stem cells within the gastrointestinal mucosa, and/or represent the convergence of multiple tumors arising at the same site.	12450423
Type 2, Reduced antigen-specific T cell proliferation	Stem Cell Exhaustion	Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures.	12451003
Pancytopenia	Stem Cell Exhaustion	He had a prolonged period of pancytopenia post-transplantation, which was thought to be due to a suboptimal dose of transplanted stem cells in combination with the effects of interferon therapy and an altered bone marrow microenvironment.	12452820
Multiple Myeloma	Stem Cell Exhaustion	We compared the efficacy of intensified chemotherapy followed by myeloablative therapy and autologous stem cell rescue with intensified chemotherapy alone in patients newly diagnosed with multiple myeloma.	12456509
ISS Stage III Plasma Cell Myeloma	Stem Cell Exhaustion	There were 261 eligible patients younger than 66 years with stage II/III multiple myeloma who were randomized after remission induction therapy with vincristine, adriamycin, dexamethasone (VAD) to receive intensified chemotherapy, that is, melphalan 140 mg/m(2) administered intravenously in 2 doses of 70 mg/m(2) (intermediate-dose melphalan [IDM]) without stem cell rescue (n = 129) or the same regimen followed by myeloablative therapy consisting of cyclophosphamide, total body irradiation, and autologous stem cell reinfusion (n = 132).	12456509
Amyloidosis	Stem Cell Exhaustion	Stem cell transplantation for the management of primary systemic amyloidosis.	12459400
Amyloidosis	Stem Cell Exhaustion	To review the characteristics and outcomes of amyloidosis patients treated with high-dose chemotherapy and stem cell reconstitution.	12459400
Amyloidosis	Stem Cell Exhaustion	The number of organs involved before stem cell transplantation for amyloidosis is the most important factor in predicting subsequent survival.	12459400
Amyloidosis	Stem Cell Exhaustion	Stem cell transplantation should be considered as a treatment option for selected patients with amyloidosis.	12459400
Glomerulonephritis, Membranoproliferative	Stem Cell Exhaustion	Membranoproliferative glomerulonephritis develops in a child with autologous stem cell transplant.	12460064
Hematuria, CTCAE, Glomerulonephritis, Kidney Failure, Proteinuria, Hypertension, CTCAE	Stem Cell Exhaustion	Here the authors report on a 5-year-old pediatric autologous stem cell recipient, in whom type I membranoproliferative glomerulonephritis developed 111 days after bone marrow transplantation and presented with hematuria, hypertension, proteinuria, and renal failure.	12460064
Toxic effect	Stem Cell Exhaustion	Low-dose (550 cGy), single-exposure total body irradiation and cyclophosphamide: consistent, durable engraftment of related-donor peripheral blood stem cells with low treatment-related mortality and fatal organ toxicity.	12463480
Toxic effect	Stem Cell Exhaustion	On the basis of observations of dog models and from earlier studies with humans, we hypothesized that a low-dose (550 cGy) TBI-based conditioning regimen would result in sustained engraftment of HLA-matched sibling peripheral blood stem cells (PBSC) with low treatment-related mortality (TRM) and low serious organ toxicity if the TBI was given as a single dose and at a high dose rate.	12463480
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Detection, isolation, and stimulation of quiescent primitive leukemic progenitor cells from patients with acute myeloid leukemia (AML).	12468427
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Possible explanations for the preservation of naive lymphocytes include (1) that the naive T cells differentiated from co-existing normal stem cells or (2) that long-lived naive T cells persisted from the CML onset and expanded peripherally (thymus independent).	12472572
Neutropenia, Unknown (origin) (qualifier value), Infection, Aplastic Anemia, Toxic effect	Stem Cell Exhaustion	In patients with idiopathic severe aplastic anaemia who are treated with immunosuppressive agents to combat T lymphocyte-mediated destruction of haematopoietic progenitor cells, neutropenia is a major cause of infections and toxicity.	12472591
Transfusion Reaction	Stem Cell Exhaustion	Early diagnosis and successful treatment of a patient with transfusion-associated GVHD with autologous peripheral blood progenitor cell transplantation.	12473136
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	A 61-year-old woman with chronic lymphocytic leukemia (CLL) was treated with fludarabine followed by combination chemotherapy and high-dose radioimmunotherapy and peripheral blood progenitor cell (PBPC) rescue.	12473136
THM gene	Stem Cell Exhaustion	Multidisciplinary therapy including high-dose chemotherapy followed by peripheral blood stem cell transplantation for invasive thymoma.	12475873
Thymoma	Stem Cell Exhaustion	We describe two patients with invasive thymomas who responded to high-dose chemotherapy followed by peripheral blood stem cell transplantation (PBSCT) combined with surgery and radiotherapy.	12475873
Multiple Myeloma, Harvesting of peripheral blood stem cells	Stem Cell Exhaustion	Patients (n = 69) with multiple myeloma undergoing peripheral blood stem cell collection (PBSC) were treated with cyclophosphamide and a combination of recombinant methionyl human granulocyte colony-stimulating factor (r-metHuG-CSF, filgrastim) and recombinant methionyl human stem cell factor (r-metHuSCF, ancestim).	12476276
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	'Relative' chemotherapy sensitivity: the impact of number of salvage regimens prior to autologous stem cell transplant for relapsed and refractory aggressive non-Hodgkin's lymphoma.	12476281
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Factors influencing the collection of peripheral blood stem cells in patients with acute myeloblastic leukemia and non-myeloid malignancies.	12479846
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Factors influencing the collection of autologous peripheral blood stem cells (PBSCs) were studied in 182 mobilization procedures performed on 145 consecutive patients with acute myeloblastic leukemia (AML; n=67) and with various non-myeloid malignancies (NMM; n=78).	12479846
Myeloproliferative disease, DPM1 gene	Stem Cell Exhaustion	The telomere in mature myeloid cells derived from abnormal progenitor cells of myeloproliferative diseases (MPDs) may shorten more rapidly than that in T lymphocytes, which are considered to be derived from normal clones.	12482501
DPM1 gene	Stem Cell Exhaustion	The results support the disease theory that MPDs result from extensive proliferation of myeloid progenitor cells, leading to accelerated telomere length shortening in mature granulocytes.	12482501
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Blast crisis of CML is a kind of disease of stem cell.	12485536
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	It is controversial whether the excessive apoptosis in myelodysplasia predominantly involves the subset of progenitor cells or of maturing cells.	12486320
Leukemia, Myelocytic, Acute, Acute lymphocytic leukemia	Stem Cell Exhaustion	Transplantation of peripheral blood stem cells as compared with bone marrow from HLA-identical siblings in adult patients with acute myeloid leukemia and acute lymphoblastic leukemia.	12488410
White blood cell count decreased	Stem Cell Exhaustion	The blood samples were obtained before the initiation of mobilization chemotherapy, at the phase of maximal leukopenia and on the second day of stem cell harvest.	12489568
White blood cell count decreased	Stem Cell Exhaustion	Serum leptin levels decreased significantly at the leukopenia phase and remained suppressed in the stem cell harvest phase (means +/- standard error means (SEM): 12.2 +/- 2.4 vs. 7.7 +/- 1.5 vs. 9.3 +/- 1.9 ng mL(-1)).	12489568
Hematological Disease	Stem Cell Exhaustion	Leptin was demonstrated to stimulate the proliferation of hematopoietic stem cells in vitro, but there is scarce information concerning serum leptin levels in patients with hematological diseases.	12489568
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Allogeneic stem cell transplantation was unanimously considered as the only curative treatment for MDS patients, and recommendations on its use were agreed based on patient's age, risk, clinical features and donor availability.	12495903
Neoplasms, Aggressive course	Stem Cell Exhaustion	Malignant mixed mesodermal tumors (MMMTs) are uncommon, highly aggressive tumors of the uterus composed of both carcinomatous and sarcomatous elements, both likely to be derived from the same original stem cell.	12497688
Hematologic Neoplasms	Stem Cell Exhaustion	Patients with hematologic malignancies were randomized to receive marrow versus blood stem cells, which contain approximately 10 times more lymphocytes than marrow.	12506030
Medial collateral ligament, Mantle cell lymphoma, Neoplasms	Stem Cell Exhaustion	We report the case of a 49 year-old female with advanced mantle cell lymphoma (MCL), who successfully underwent auto-peripheral blood stem cell transplant (auto-PBSCT) in combination with in vivo purging of tumor cells using rituximab.	12506485
Lymphoma	Stem Cell Exhaustion	[Persistent T-cell mixed chimerism in a case of malignant lymphoma after nonmyeloablative allogeneic peripheral blood stem cell transplantation].	12508489
Lymphoma, Follicular	Stem Cell Exhaustion	We describe a 51-year-old woman with recurrent follicular lymphoma from the age of 47 despite chemo-radio therapy, who subsequently underwent nonmyeloablative stem cell transplantation with conditioning consisting of fludarabine and low-dose total body irradiation (2 Gy).	12508489
Adenovirus Infections, Liver Failure, Acute	Stem Cell Exhaustion	We report a fatal case of disseminated adenovirus infection with fulminant hepatic failure in an 8-month-old child after peripheral blood stem cell transplantation.	12508794
Keratopathy	Stem Cell Exhaustion	Management of aniridic keratopathy with keratolimbal allograft: a limbal stem cell transplantation technique.	12511357
Keratopathy	Stem Cell Exhaustion	We evaluated the role of keratolimbal allograft (KLAL), a stem cell transplantation technique, for the treatment of patients with aniridic keratopathy.	12511357
Multiple Myeloma	Stem Cell Exhaustion	Comparison of microvessel density before and after peripheral blood stem cell transplantation in multiple myeloma patients and its clinical implications: multicenter trial.	12512842
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Because high-dose chemotherapy combined with autologous stem cell transplantation (SCT) improves the response rate, event-free survival, and overall survival in patients with multiple myeloma (MM), we studied the changes in bone marrow microvessel density (MVD) in 21 patients who underwent high-dose chemotherapy combined with autologous SCT to determine whether there was persistently increased angiogenesis at the time of response.	12512842
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Implantation of bone-marrow stem cells in the heart might be a new method to restore tissue viability after myocardial infarction.	12517467
Chronic idiopathic neutropenia, Myeloid Progenitor Cells	Stem Cell Exhaustion	Impaired granulocytopoiesis in patients with chronic idiopathic neutropenia is associated with increased apoptosis of bone marrow myeloid progenitor cells.	12517813
Tumor necrosis	Stem Cell Exhaustion	LTBMC stromal layers from patients produced abnormally high amounts of tumor necrosis factor alpha and cytokine levels in culture supernatants inversely correlated with the number of myeloid progenitor cells and positively with the proportion of apoptotic CD34(+) cells.	12517813
Neoplasms	Stem Cell Exhaustion	After 1986, six of eight patients received cisplatin-based chemotherapy, including three who received additional high-dose chemotherapy with a supporting peripheral blood stem cell transplantation until tumor markers normalized.	12518361
filgrastim	Stem Cell Exhaustion	It is not known whether increasing the dose of filgrastim after mobilizing chemotherapy improves collection of peripheral blood progenitor cells (PBPC) and leads to faster hematopoietic engraftment after autologous transplantation.	12519430
Multiple Myeloma	Stem Cell Exhaustion	High-dose therapy followed by autologous haematopoietic stem cell transplantation in multiple myeloma.	12520826
Multiple Myeloma	Stem Cell Exhaustion	We analysed the outcome of 29 myeloma patients who had autologous haematopoietic stem cell transplantation (AHSCT) in our institution over an 8-year period.	12520826
Herpes Simplex Infections	Stem Cell Exhaustion	Oral valacyclovir versus intravenous acyclovir in preventing herpes simplex virus infections in autologous stem cell transplant recipients.	12523578
Herpes Simplex Infections, Simplexvirus	Stem Cell Exhaustion	Patients who are seropositive for herpes simplex virus (HSV) and are undergoing autologous marrow or peripheral blood stem cell transplantation require prophylaxis for HSV infection.	12523578
Allogeneic Hematopoietic Stem Cell Transplantation, Chronic graft-versus-host disease	Stem Cell Exhaustion	Risk factors for moderate-to-severe chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.	12523580
Senter syndrome	Stem Cell Exhaustion	[Limbal stem cell deficiency associated with KID syndrome, about a case].	12527832
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	The aim of this study was to determine whether administration of BB-10010, a synthetic stem cell inhibitor, would allow more intensive chemotherapy to be administered to patients with newly diagnosed high grade NHL.	12527943
Lymphoma, Non-Hodgkin, Neoplasms	Stem Cell Exhaustion	The study included 70 patients with high-grade malignant non-Hodgkin's lymphoma (Kiel) who received the following treatment: group 1(24)--6-8 cycles of CHOP; group 2 (relapse or tumor progression after standard chemotherapy--13)--6 cycles of CHOP and Dexa-BEAM, and group 3 (relapse or tumor progression after standard chemotherapy--8)--6 cycles of CHOP plus Dexa-BEAM plus autologous hemopoietic cell transplantation with CBV or BEAM conditioning regimen (bone marrow or peripheral stem cells).	12530261
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	We treated 39 patients with aggressive poor risk NHL with double-CHOP (D-CHOP) chemotherapy followed by high-dose therapy (HDT) with or without peripheral blood stem cell transfusion (PBSCT).	12533036
Granulocytic Sarcoma	Stem Cell Exhaustion	Disseminated granulocytic sarcoma treated with allogeneic peripheral blood stem-cell transplantation.	12533051
Granulocytic Sarcoma	Stem Cell Exhaustion	This case demonstrates the effectiveness of allogeneic stem-cell transplantation in the treatment of progressive granulocytic sarcoma present after high-dose chemotherapy.	12533051
Mucocutaneous candidiasis, Polyneuropathy	Stem Cell Exhaustion	The patient had medullary plasmocytosis with lambda light chain restricted expression and underwent autologous stem cell transplantation, which resulted in progressive regression of mucocutaneous signs and stabilization of the polyneuropathy.	12534612
Aggressive natural killer-cell leukemia	Stem Cell Exhaustion	A diagnosis of aggressive NK cell leukemia was made, the patient was treated with induction chemotherapy and cord blood stem cell transplantation, and he is well now.	12537767
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	She was diagnosed as AML (FAB: M2) with monosomy 7, and successfully treated by an intensive combination chemotherapy followed by an autologous peripheral blood stem cell transplantation.	12537982
Small cell carcinoma of lung	Stem Cell Exhaustion	The tyrosine-kinase receptor c-kit and its ligand stem cell factor are coexpressed in many small cell lung cancer (SCLC) cell lines, leading to the hypothesis that this coexpression constitutes an autocrine growth loop.	12538468
Leukemia, Mast-Cell	Stem Cell Exhaustion	Consolidation therapy with autologous blood stem cell transplantation in a patient with primary plasma cell leukaemia.	12542443
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Eighteen patients (median age 59 years, range 36-73 years) with de novo (n = 13) and secondary (n = 5) AML in morphological CR1, who were not candidates for conventional allografting, received non-myeloablative peripheral blood stem cell transplants from human leucocyte antigen identical sibling donors after conditioning with 2 Gy total body irradiation (TBI; n = 10) or 2 Gy TBI and 90 mg/m2 of fludarabine (n = 8).	12542488
Lymphoma	Stem Cell Exhaustion	As granulocyte colony-stimulating factor (G-CSF) is routinely used in the mobilization of stem cells for transplantation, we evaluated its effects on telomerase activity and regulation, and on telomere dynamics, in normal donors and selected lymphoma patients.	12542495
Pleuropulmonary blastoma	Stem Cell Exhaustion	High-dose chemotherapy and autologous peripheral blood stem cell rescue in a patient with pleuropulmonary blastoma.	12544779
Thrombus	Stem Cell Exhaustion	Pulmonary cytolytic thrombi: unusual complication of hematopoietic stem cell transplantation.	12544782
Pulmonary Complication, Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	Pulmonary complications of hematopoietic stem cell transplantation (HSCT), including peripheral blood stem cell transplantation (PBSCT) and bone marrow transplantation, are frequent and often life-threatening.	12544782
Herpesvirus 7, Human, Communicable Diseases	Stem Cell Exhaustion	Human herpesvirus (HHV)-6 and HHV-7: two closely related viruses with different infection profiles in stem cell transplantation recipients.	12552442
Rhabdomyosarcoma	Stem Cell Exhaustion	Regression of refractory rhabdomyosarcoma after allogeneic stem-cell transplantation.	12554526
Rhabdomyosarcoma	Stem Cell Exhaustion	Although further investigation is required, allogeneic stem-cell transplantation could provide a new therapeutic option for refractory rhabdomyosarcoma.	12554526
Graft-vs-Host Disease	Stem Cell Exhaustion	Matched and mismatched allogeneic stem-cell transplantation from unrelated donors using combined graft-versus-host disease prophylaxis including rabbit anti-T lymphocyte globulin.	12560442
Hematologic Neoplasms	Stem Cell Exhaustion	One hundred adult patients (median age, 37 years; range, 17 to 65 years) with hematologic malignancies underwent transplantation in early disease (first complete remission [CR1] or first chronic phase [CP1]; n = 34) or in advanced disease (second complete remission or second chronic phase, no remission, refractory; n = 66) with nondepleted bone marrow (n = 87) or peripheral-blood-derived (n = 13) stem cells from an HLA-A, HLA-B, HLA-DRB1, or HLA-DQB1 identical (n = 75) or mismatched (one antigen, n = 21; two to three antigens, n = 4) unrelated donor.	12560442
Behcet Syndrome, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Successful cord blood stem cell transplantation for myelodysplastic syndrome with Behcet disease.	12568304
Behcet Syndrome	Stem Cell Exhaustion	Behcet disease was first controlled with steroids and diet followed by chemotherapy and cord blood stem cell transplantation (SCT).	12568304
Degenerative polyarthritis	Stem Cell Exhaustion	Differentiated stem cell spheroids represent an attractive tool for use in drug development and identification of drug targets in OA cartilage-like tissue outside the human body.	12571852
Extramedullary, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Extramedullary blast crisis of chronic myeloid leukemia after allogeneic hematopoietic stem cell transplantation mimicking aggressive, translocation t(14;18)-positive B-cell lymphoma.	12574966
Neoplasms, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We report the case of a 42-year-old male patient who was diagnosed with a large tumor of the right thoracic aperture 30 months after unrelated hematopoietic stem cell transplantation (HSCT) for accelerated phase of Philadelphia chromosome (Ph)-positive chronic myeloid leukemia (CML).	12574966
Polycythemia Vera, Triggered by, Decreased platelet count	Stem Cell Exhaustion	We suggest that at least some cases of polycythemia vera may have an unstable hematopoietic stem cell pool in nature, which could contribute to the development of unprovoked cyclic thrombocytopenia.	12574969
Pterygium	Stem Cell Exhaustion	[Corneal limbal stem cell autograft and conjunctiva transplantation for treatment of pterygium].	12579707
Pterygium	Stem Cell Exhaustion	To observe the therapeutic effects of corneal limbal stem cell autograft and conjunctiva transplantation for the treatment of pterygium.	12579707
Pterygium	Stem Cell Exhaustion	Corneal limbal stem cell autograft and conjunctiva transplantation were performed on 38 cases (43 eyes) with newly developed or recurrent pterygium.	12579707
Pterygium	Stem Cell Exhaustion	To provide new stem cell source for injured limbus with limbal epithelial autograft transplantation is a reasonable therapeutic method for treatment of pterygium.	12579707
Multiple Myeloma	Stem Cell Exhaustion	Peripheral blood stem cell contamination evaluated by a highly sensitive molecular method fails to predict outcome of autotransplanted multiple myeloma patients.	12580954
Multiple Myeloma	Stem Cell Exhaustion	The mobilization of peripheral blood stem cells was studied in 984 multiple myeloma patients, including 106 patients aged >/= 70 years.	12580955
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Imatinib mesylate (STI571) treatment in patients with chronic-phase chronic myelogenous leukaemia previously submitted to autologous stem cell transplantation.	12580969
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Thirty-three chronic-phase CML patients who were resistant or intolerant to interferon (IFN) and had been previously submitted to autologous stem cell transplantation were treated with imatinib for a median of 14 months (range: 6-19 months).	12580969
Chronic disease, Atherogenesis, Carcinogenesis	Stem Cell Exhaustion	The process of gap junctional inter-cellular communication (GJIC), which has been implicated in the evolution from the single cell organism to the multi-cellular organisms, requiring growth control, differentiation, apoptosis, adaptive response capability of differentiated cells and senescence, is speculated to be a shared mechanism in stem cell biology and in many chronic disease processes (teratogenesis; carcinogenesis, atherogenesis, diabetigenesis, etc.).	12581626
Cardiovascular Diseases, Endothelial dysfunction	Stem Cell Exhaustion	We hypothesized that endothelial progenitor cells derived from bone marrow have a role in ongoing endothelial repair and that impaired mobilization or depletion of these cells contributes to endothelial dysfunction and cardiovascular disease progression.	12584367
Endothelium, Cardiovascular Diseases	Stem Cell Exhaustion	These findings suggest that endothelial injury in the absence of sufficient circulating progenitor cells may affect the progression of cardiovascular disease.	12584367
Hollings Cancer Center, Carcinoma, Squamous cell carcinoma, Cholangiocarcinoma	Stem Cell Exhaustion	There are several possibilities for the origin of squamous cell carcinoma in this case: marked squamous metaplastic change of cholangiocarcinoma and/or HCC, and carcinoma originating from pleuripotential stem cells.	12588436
Neoplasms	Stem Cell Exhaustion	CD34, which is expressed in hematopoietic stem cells, endothelial progenitor cells and vascular endothelial cells, is observed in most SFT and some investigators believe that its expression is a definitive marker of this tumor.	12588446
Childhood Breast Carcinoma	Stem Cell Exhaustion	Mobilization of peripheral blood progenitor cells with a combination of cyclophosphamide, r-metHuSCF and filgrastim in patients with breast cancer previously treated with chemotherapy.	12592344
Multiple Myeloma, Communicable Diseases	Stem Cell Exhaustion	CD34+-selected versus unmanipulated autologous stem cell transplantation in multiple myeloma: impact on dendritic and immune recovery and on complications due to infection.	12598356
Infection, Multiple Myeloma	Stem Cell Exhaustion	We evaluated immunological and dendritic reconstitution in 72 myeloma patients who had undergone CD34+-selected (n = 45) and unmanipulated (n = 27) stem cell transplant, and its correlation with infections.	12598356
Gastrointestinal mucositis	Stem Cell Exhaustion	Glutamine-enriched parenteral nutrition after autologous peripheral blood stem cell transplantation: effects on immune reconstitution and mucositis.	12604409
Hematologic Neoplasms, Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	We designed two consecutive randomized clinical trials to evaluate the role of glutamine-enriched parenteral nutrition (GEPN) in patients with hematologic malignancies submitted to high dose chemotherapy and autologous peripheral blood stem cell transplantation (aPBSCT) or immunoselected CD34+ aPBSCT.	12604409
leukemia	Stem Cell Exhaustion	We suggest that environmental factors in addition to a genetic defect in the pluripotent hematopoietic stem cells may be associated with the occurrence of this familial leukemia.	12607996
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Prognostic value of pretransplantation positron emission tomography using fluorine 18-fluorodeoxyglucose in patients with aggressive lymphoma treated with high-dose chemotherapy and stem cell transplantation.	12609836
Failure	Stem Cell Exhaustion	The study assessed the prognostic value of fluorine 18-fluorodeoxyglucose positron emission tomography ([18F]FDG-PET) after salvage chemotherapy before high-dose chemotherapy with stem cell transplantation (HDT/SCT) in patients with induction failure or relapsing chemosensitive lymphoma.	12609836
Metaplastic carcinoma	Stem Cell Exhaustion	Novel and classic myoepithelial/stem cell markers in metaplastic carcinomas of the breast.	12610349
HD Term Type, corticotropin-releasing factor, human, Stem Cell Factor	Stem Cell Exhaustion	Purified 1 x 10(4) circulating CD34+ cells isolated from rHuEPO-hyporesponsive HD patients (EPO-H; n = 10), rHuEPO-responsive non-HD patients with CRF (EPO-R; n = 8), nonanemic HD patients without rHuEPO therapy (EPO-W/O; n = 10), and healthy volunteer controls (CON; n = 10) were subjected to a methylcellulose culture system supplemented with rHuEPO, recombinant human interleukin-3 (IL-3), recombinant human stem cell factor (SCF), and recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) for 14 days.	12612986
Medial collateral ligament	Stem Cell Exhaustion	A large multicentre study with adequate follow-up may clarify the role of significant factors affecting outcome in autologous stem cell transplantation for MCL.	12614212
Childhood Breast Carcinoma	Stem Cell Exhaustion	Use of the anti-idiotype breast cancer vaccine 11D10 in conjunction with autologous stem cell transplantation in patients with metastatic breast cancer.	12620153
Childhood Breast Carcinoma	Stem Cell Exhaustion	The results of cytotoxic therapy, including dose-intensive therapy requiring autologous stem cell transplantation (ASCT), have been disappointing in patients with metastatic breast cancer, as almost all patients eventually experience disease progression.	12620153
Stem Cell Factor	Stem Cell Exhaustion	The highest proliferation was usually observed in the presence of Flt3-Ligand (Flt3-L) when single cytokines were examined, and these responses could be further increased especially by combining Flt3-L with interleukin 3 (IL3), IL7 or stem cell factor (SCF).	12620297
Colon Carcinoma	Stem Cell Exhaustion	Low-intensity conditioning and hematopoietic stem cell transplantation in patients with renal and colon carcinoma.	12621459
Neoplasms	Stem Cell Exhaustion	We have evaluated whether allogeneic hematopoietic stem cell transplantation (HSCT) could induce an antitumor effect in patients with metastatic solid tumors.	12621459
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation in multiple myeloma: improved survival in nonsecretory multiple myeloma but lack of influence of age, status at transplant, previous treatment and conditioning regimen.	12621476
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	High-dose therapy with autologous stem cell transplantation (ASCT) has become the treatment of choice for symptomatic eligible patients with multiple myeloma (MM).	12621476
RAPH1 gene, EBV-Related Post-Transplant Lymphoproliferative Disorder	Stem Cell Exhaustion	Fatal EBV-related post-transplant lymphoproliferative disorder (LPD) after matched related donor nonmyeloablative peripheral blood progenitor cell transplant.	12621485
Multiple Myeloma	Stem Cell Exhaustion	Cyclophosphamide with granulocyte colony stimulating factor (G-CSF) is commonly used to mobilize stem cells in multiple myeloma.	12621490
Multiple Myeloma	Stem Cell Exhaustion	Vinorelbine and G-CSF allow precise timing and harvesting of sufficient stem cells, and might be an alternative to cyclophosphamide in the mobilization of stem cells for autologous transplantation in multiple myeloma.	12621490
Multiple Myeloma	Stem Cell Exhaustion	Mobilization of peripheral blood progenitor cells with vinorelbine and granulocyte colony-stimulating factor in multiple myeloma patients is reliable and cost effective.	12621490
Engraftment syndrome	Stem Cell Exhaustion	Engraftment syndrome after autologous hematopoietic stem cell transplant supported by granulocyte-colony-stimulating factor (G-CSF) versus granulocyte-macrophage colony-stimulating factor (GM-CSF).	12621492
Engraftment syndrome	Stem Cell Exhaustion	The engraftment syndrome (ES) is a phenomenon observed in some patients undergoing autologous hematopoietic stem cell transplant (AHSCT).	12621492
LYST gene	Stem Cell Exhaustion	As AP is often life-threatening, hematopoietic stem cell transplantation has been proposed as the only curative treatment for CHS.	12621497
Demyelination	Stem Cell Exhaustion	Central and extrapontine myelinolysis following allogeneic peripheral haematopoietic progenitor cell transplantation.	12621509
Central nervous system complication, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	A 48-year-old-man in the first chronic phase of chronic myeloid leukaemia developed a central nervous system complication on day +57 after HLA-identical peripheral blood progenitor cell (PBPC) transplantation.	12621509
MRSA - Methicillin resistant Staphylococcus aureus infection, Meningoencephalitis	Stem Cell Exhaustion	Successful treatment of meningoencephalitis caused by methicillin-resistant Staphylococcus aureus with intrathecal vancomycin in an allogeneic peripheral blood stem cell transplant recipient.	12621510
MRSA - Methicillin resistant Staphylococcus aureus infection, Pathogenic organism	Stem Cell Exhaustion	Methicillin-resistant Staphylococcus aureus (MRSA) is a common infectious pathogen during stem cell trans-plantation.	12621510
Numerous, Meningoencephalitis	Stem Cell Exhaustion	We report a case of meningoencephalitis with multiple abscess formation caused by MRSA, which occurred in a 4-year-old boy soon after allogeneic peripheral blood stem cell transplantation.	12621510
Infection, Granulocytopenic disorder	Stem Cell Exhaustion	Further studies are warranted to evaluate the clinical efficacy of GTX for the treatment of uncontrolled infections in granulocytopenic stem cell transplant recipients.	12621511
Chemical injury	Stem Cell Exhaustion	Twenty eyes of 20 consecutive patients with limbal stem cell deficiency secondary to ocular chemical injury.	12623806
BMP1 gene	Stem Cell Exhaustion	Success was observed in all cases of partial limbal stem cell deficiency (PLD) and in 68.75% (11 eyes) of cases of total limbal stem cell deficiency (TLD).	12623806
BMP1 gene	Stem Cell Exhaustion	When performed in conjunction with limbal stem cell transplantation, it is also effective in most cases of TLD.	12623806
Burn injury	Stem Cell Exhaustion	A 50-year-old woman with severe chemical burns in both eyes received an AMT as a temporary patch at the acute stage, and a KLAL with AMT as a graft at the chronic stage for total limbal stem cell deficiency.	12623808
Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	A most distinctive feature of paroxysmal nocturnal hemoglobinuria (PNH) is that in each patient glycosylphosphatidylinositol-negative (GPI-) and GPI+ hematopoietic stem cells (HSCs) coexist, and both contribute to hematopoiesis.	12623835
Chromosome Aberrations	Stem Cell Exhaustion	Seventeen patients acquired t-MDS/t-AML after autologous stem cell transplantation, but no unique pattern of cytogenetic abnormalities was observed.	12623843
Kidney Failure, Chronic	Stem Cell Exhaustion	High-dose intravenous melphalan with autologous stem cell transplantation in AL amyloidosis-associated end-stage renal disease.	12631087
Dysplasia, Amyloidosis	Stem Cell Exhaustion	High-dose intravenous melphalan and autologous stem cell transplantation induce remission of the plasma cell dyscrasia in a significant proportion of patients with AL amyloidosis.	12631087
Kidney Failure, Chronic	Stem Cell Exhaustion	Between June 1994 and June 2000, 15 patients with AL amyloidosis-associated ESRD were treated with intravenous melphalan (70 to 200 mg/m2) and autologous peripheral blood stem cell transplantation.	12631087
Kidney Failure, Chronic	Stem Cell Exhaustion	High-dose intravenous melphalan with stem cell transplantation is an effective treatment in selected patients with AL amyloidosis-associated ESRD.	12631087
Communicable Diseases, herpesvirus 3, human, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Infection with Varicella-Zoster virus (VZV) is an exceptionally rare complication of chronic myelogenous leukemia (CML) without stem cell transplantation.	12631595
Degenerative disorder	Stem Cell Exhaustion	Embryonic stem cells: new possible therapy for degenerative diseases that affect elderly people.	12634295
Degenerative disorder, trauma qualifier	Stem Cell Exhaustion	Stem cell-based therapies for degenerative disorders and injuries are promising in the new era.	12634415
Bone necrosis	Stem Cell Exhaustion	Multipotential mesenchymal stem cells from femoral bone marrow near the site of osteonecrosis.	12634415
Leukemia, Myelocytic, Acute, BCR gene	Stem Cell Exhaustion	23 patients with ALL (n=9) and AML (n=14) underwent nonmyeloablative stem cell transplantation (NST) from an HLA-identical donor after conditioning with fludarabine (180 mg/m(2)), busulfan (8 mg/kg) and anti-T-lymphocyte globulin (40 mg/kg).	12634724
Multiple Myeloma	Stem Cell Exhaustion	Low-dose or intermediate-dose cyclophosphamide plus granulocyte colony-stimulating factor for progenitor cell mobilisation in patients with multiple myeloma.	12634725
Toxic effect	Stem Cell Exhaustion	While these regimens seem to be equally effective in terms of progenitor cell mobilisation in newly diagnosed patients with MM, LD-CY+G-CSF is preferential because of more optimal resource utilisation and more favourable toxicity profile.	12634725
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Cyclophosphamide (CY) combined with granulocyte colony-stimulating factor (G-CSF) is commonly used to mobilise blood progenitor cells to support high-dose therapy in patients with multiple myeloma (MM).	12634725
Engraftment syndrome	Stem Cell Exhaustion	Engraftment syndrome following autologous hematopoietic stem cell transplantation: definition of diagnostic criteria.	12634731
Engraftment syndrome	Stem Cell Exhaustion	Engraftment syndrome (ES) is an increasingly reported complication of hematopoietic stem cell transplantation (HSCT).	12634731
Dyskeratosis Congenita	Stem Cell Exhaustion	Nonmyeloablative allogeneic hematopoietic stem cell transplantation for treatment of Dyskeratosis congenita.	12634734
Neutropenia, Dyskeratosis Congenita, Autosomal Recessive, Decreased platelet count	Stem Cell Exhaustion	We describe the treatment of a 10-year-old girl with autosomal recessive Dyskeratosis congenita (DC), neutropenia, thrombocytopenia and combined immunodeficiency by nonmyeloablative hematopoietic stem cell transplantation.	12634734
Neurodegenerative Disorders, Parkinson Disease, "Huntingtons Disease Pathway	Stem Cell Exhaustion	Neural and stem cell transplantation is emerging as a potential treatment for neurodegenerative diseases from Parkinson's to Huntington's disease.	12635741
Unknown (origin) (qualifier value), Hemorrhagic diarrhea	Stem Cell Exhaustion	Among 6 predefined clinical categories (stem cell transplantation, pregnant/postpartum, drug association, bloody diarrhea, additional/alternative disorder, idiopathic), severe deficiency occurred only among pregnant/postpartum (2 of 10) and idiopathic (16 of 48) patients.	12637323
MYELODYSPLASTIC SYNDROME, Fanconi Anemia, Chromosome Aberrations	Stem Cell Exhaustion	Myelodysplastic and leukemic stem cell clones that evolve in children and adults with Fanconi anemia universally bear complex cytogenetic abnormalities.	12637330
Complication Aspects	Stem Cell Exhaustion	[Corneal complications after hematopoietic stem cell transplantation].	12640552
Complication Aspects, Dry Eye Syndromes	Stem Cell Exhaustion	To evaluate the incidence and clinical course of corneal complications in patients with severe dry eye syndrome after hematopoietic stem cell transplantation (HSCT).	12640552
Sjogrens Syndrome	Stem Cell Exhaustion	50 consecutive patients (aged 9-65 years; average=42+/-11 years) with Sjogren-like syndrome after hematopoietic stem cell transplantation were examined.	12640552
Pseudomembranous conjunctivitis	Stem Cell Exhaustion	Two patients had limbal stem cell insufficiency or pseudomembranous conjunctivitis, both due to conjunctival graft-versus-host reaction.	12640552
Complication Aspects, infectious - Entity Risk, "Sjogrens Syndrome	Stem Cell Exhaustion	Patients with Sjogren-like dry eye syndrome after hematopoietic stem cell transplantation are at high risk to develop corneal complications.These complications may result from an aggressive extension of the graft-versus-host reaction towards the conjunctiva and/or the lacrimal gland and seem to occur more often during the period of reduction of systemic immunosuppressive therapy.Furthermore, infectious as well as trophic or toxic corneal complications may be supported by local immunosuppressive therapy.	12640552
Symptom Distress Scale	Stem Cell Exhaustion	Symptom distress, functional status and health-related quality of life before high-dose chemotherapy with stem-cell transplantation.	12641559
Symptom Distress Scale, malignant disease, Global Stable Disease in Lymph Nodes	Stem Cell Exhaustion	The aims of this study were to describe how a group of patients with different malignant diseases perceived symptom distress (SD), functional status (FS) and health-related quality of life (HRQOL) on admission to the hospital for stem-cell transplantation (SCT), to compare the obtained data regarding FS and HRQOL with similar data from two general-population groups, and to relate the results to disease- and treatment-specific data.	12641559
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Autologous stem cell transplant for relapsed and refractory peripheral T-cell lymphoma: variable outcome according to pathological subtype.	12648067
T-Cell Lymphoma	Stem Cell Exhaustion	The purpose of this study was to evaluate the outcome of high-dose chemotherapy (HDCT) followed by autologous haematopoietic stem cell transplant (ASCT) for patients with relapsed T-cell non-Hodgkin's lymphoma.	12648067
Multiple Myeloma	Stem Cell Exhaustion	Optimal methods of stem cell mobilization in multiple myeloma are undefined, and contaminating clonotypic cells could contribute to disease recurrence.	12649134
Hematologic Neoplasms	Stem Cell Exhaustion	Low transplant related mortality in older patients with hematologic malignancies undergoing autologous stem cell transplantation.	12651269
Toxic effect	Stem Cell Exhaustion	These data show that reduced intensity stem cell transplantation in children permits rapid engraftment from siblings with little toxicity.	12652465
Graft-vs-Host Disease	Stem Cell Exhaustion	The role of host DCs in the development of GVHD following allogeneic stem cell transplantation in humans, however, is unclear.	12652467
Hematologic Neoplasms, Acute GVH disease	Stem Cell Exhaustion	Lowered-intensity preparative regimen for allogeneic stem cell transplantation delays acute graft-versus-host disease but does not improve outcome for advanced hematologic malignancy.	12652470
Neoplasms	Stem Cell Exhaustion	We prospectively tested whether a moderate reduction of the intensity of the preparative regimen would lead to significant reduction in regimen-related toxicity without compromising tumor control in a cohort of 44 patients ineligible for conventional hematopoietic stem cell transplantation.	12652470
Ductal Carcinoma	Stem Cell Exhaustion	In ductal carcinomas, malignant p63-positive cells have an immunophenotype similar to that of myoepithelial cells, suggesting that these cells originate from a primary progenitor cell that underwent divergent differentiation to ductal and myoepithelial cells during clonal expansion.	12653579
Hyperplastic Polyp	Stem Cell Exhaustion	Therefore hyperplastic polyps might be interpreted as the outcome of abnormal cell differentiation of stem cells.	12653947
Philadelphia chromosome positive chronic myelogenous leukemia	Stem Cell Exhaustion	After two autologous stem cell transplantation, the patient reverted to chronic phase with a decrease in the proportion of Ph chromosome-positive cells under imatinib.	12656747
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease after nonmyeloablative versus conventional hematopoietic stem cell transplantation.	12663454
Graft-vs-Host Disease	Stem Cell Exhaustion	It is unknown whether the severity, timing, and quality of graft-versus-host disease (GVHD) may be different after nonmyeloablative as compared with myeloablative hematopoietic stem cell transplantation (HSCT).	12663454
Malignant Neoplasms	Stem Cell Exhaustion	New malignancies after blood or marrow stem-cell transplantation in children and adults: incidence and risk factors.	12663726
Malignant Neoplasms	Stem Cell Exhaustion	To determine the incidence and risk factors for the development of new malignancies occurring after stem-cell transplantation (SCT).	12663726
Fanconi Anemia	Stem Cell Exhaustion	Successful T-cell-depleted, related haploidentical peripheral blood stem cell transplantation in a patient with Fanconi anaemia using a fludarabine-based preparative regimen without radiation.	12665837
Bone marrow hypocellularity, Fanconi Anemia	Stem Cell Exhaustion	Haematopoietic stem cell transplantation (HSCT) represents the treatment of choice for severe bone marrow failure in patients with Fanconi anaemia (FA).	12665837
Peripheral Blood Stem Cells, Neoplasms	Stem Cell Exhaustion	Successive double high-dose chemotherapy with peripheral blood stem cell rescue collected during a single leukapheresis round in patients with high-risk pediatric solid tumors: a pilot study in a single center.	12665839
Neoplasms	Stem Cell Exhaustion	In total, 18 of 26 double high-dose chemotherapies (HDCT) in pediatric solid tumors were rescued with peripheral blood stem cells collected during a single leukapheresis round (single-harvest group, SHG).	12665839
Steroid-Refractory Pneumonitis, Chronic graft-versus-host disease	Stem Cell Exhaustion	Extracorporeal photopheresis therapy in the management of steroid-refractory or steroid-dependent cutaneous chronic graft-versus-host disease after allogeneic stem cell transplantation: feasibility and results.	12665841
Stable chronic Graft vs Host Disease, Steroid-Refractory Pneumonitis, Chronic graft-versus-host disease	Stem Cell Exhaustion	We conducted a retrospective analysis of all allogeneic stem cell transplantation (ASCT) patients started on extracorporeal photopheresis (ECP) for the management of steroid-dependent (SD) or steroid-refractory (SR) cutaneous chronic graft-versus-host disease (cGVHD) following ASCT during a 36-month period (9/98-8/01).	12665841
Lymphoma, Follicular	Stem Cell Exhaustion	PCR detection of residual Bcl-2/IgH-positive cells after high-dose therapy with autologous stem cell transplantation is a prognostic factor for event-free survival in patients with low-grade follicular non-Hodgkin's lymphoma.	12665842
Lymphoma, Follicular	Stem Cell Exhaustion	This study was designed to evaluate the results of high-dose therapy followed by purged autologous stem cell transplantation (ASCT) for patients with low-grade follicular non Hodgkin's lymphoma (LGFL), and the prognostic significance of PCR detection of residual Bcl-2/IgH-positive cells after ASCT.	12665842
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We report the case of a 59-year-old woman with Durie-Salmon stage IIIB IgGkappa multiple myeloma (MM), who presented 83 days after autologous hematopoietic stem cell transplant (HSCT) with multiple subcutaneous plasmacytomas.	12666140
Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome	Stem Cell Exhaustion	Twelve patients developed AML/MDS after salvage therapy, including four patients who developed AML/MDS after high-dose chemotherapy with autologous stem-cell transplantation.	12668650
Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome	Stem Cell Exhaustion	Treatment for secondary AML/MDS was as follows: cytarabine (Ara-C)-containing regimens (6-thioguanin, cytarabine, daunorubicin [TAD]/high-dose cytarabine, mitoxantrone [HAM], HAM, Ida-Ara-C (idarubicin + Ara-C), Ida-Flag (idarubicin, fludarabin, Ara-C, G-CSF), and idarubicin, cytarabine, etoposide [ICE]+HAM; n = 11), TAD-chemotherapy (n = 5), other regimens (n = 3), no treatment or supportive care (n = 24), palliative oral chemotherapy (n = 3), and allogeneic stem cell transplantation (n = 9).	12668650
Fibrosis Assessment, Primary Myelofibrosis	Stem Cell Exhaustion	Idiopathic myelofibrosis (IMF) is a clonal stem cell disorder characterized by reactive fibrosis of bone marrow sustained by a complex cytokine network.	12670334
Toxic effect, Amyloidosis	Stem Cell Exhaustion	To test the toxicity and efficacy of thalidomide in AL amyloidosis we initiated a phase I/II trial for patients with AL amyloidosis, most of whom had failed prior therapy with high-dose melphalan and autologous stem cell transplantation.	12672274
Graft-vs-Host Disease	Stem Cell Exhaustion	A retrospective analysis was performed to evaluate the utilization and risk factors for RBC transfusions including age and sex of recipient, HLA matching between donor and recipient, disease status at time of BMT, the occurrence of GVHD, ABO blood group compatibility, the source of progenitor cells and the Hb level before BMT (PT-Hb).	12675724
Graft-vs-Host Disease	Stem Cell Exhaustion	The source of progenitor cells and the development of GVHD did not influence transfusion requirements.	12675724
Kidney Failure, Acute, Amyloidosis	Stem Cell Exhaustion	Incidence and outcome of acute renal failure complicating autologous stem cell transplantation for AL amyloidosis.	12675865
Toxic effect, Kidney Failure, Acute, Amyloidosis	Stem Cell Exhaustion	High-dose intravenous melphalan and autologous peripheral blood stem cell transplantation (HDM/SCT) is an effective treatment for AL amyloidosis but is associated with significant toxicity, including the development of acute renal failure (ARF).	12675865
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Second-line chemotherapy followed by high-dose therapy (HDT) with autologous stem cell transplantation (ASCT) cures less than half of the patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL).	12676776
PAFAH1B1 wt Allele, Myeloid Leukemia, Chronic, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	A regimen of busulfan and cyclophosphamide is standard therapy before transplantation of allogeneic hematopoietic stem cells in patients with chronic myelogenous leukemia (CML) or myelodysplastic syndrome (MDS).	12676781
Acute lymphocytic leukemia	Stem Cell Exhaustion	Induction of long-term remission of a relapsed childhood B-acute lymphoblastic leukemia with rituximab chimeric anti-CD20 monoclonal antibody and autologous stem cell transplantation.	12679650
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Successful immunotherapy in early relapse of acute myeloid leukemia after nonmyeloablative allogeneic stem cell transplantation.	12679886
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We report on a 35-year-old woman who underwent allogeneic stem cell transplantation (SCT) in second complete remission (CR) of acute myeloid leukemia (AML) after reduced-intensity conditioning with fludarabine and 2 Gy of total body irradiation.	12679886
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Amifostine does not preferentially stimulate the growth of residual polyclonal progenitor cells in myelodysplastic syndromes.	12681358
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Although some Ph+ CML patients with clonal evolution can have a complete cytogenetic response to imatinib mesylate, responses tend to be brief, and such patients may benefit from subsequent stem cell transplantation.	12684401
Mastocytosis	Stem Cell Exhaustion	Recently, it could be shown that systemic mastocytosis (SM) is a clonal disorder often exhibiting mutations of c-kit, a protooncogene encoding the tyrosine kinase receptor for stem cell factor (SCF).	12688351
Hemolysis (biological function)	Stem Cell Exhaustion	Massive immune hemolysis after non-myeloablative allogeneic peripheral blood stem cell transplantation with minor ABO-incompatibility.	12688358
TSPYL2 gene, Primary cutaneous gamma-delta T-cell lymphoma	Stem Cell Exhaustion	A 35-year-old male, blood group B, Rh(D)+ type, received an allogeneic peripheral blood stem cell (PBSC) transplant after a non-myeloablative regimen of fludarabine and cyclophosphamide for resistant gammadelta cutaneous T-cell lymphoma (CTCL).	12688358
Mycoses	Stem Cell Exhaustion	Risks and outcomes of invasive fungal infections in recipients of allogeneic hematopoietic stem cell transplants after nonmyeloablative conditioning.	12689933
Infection	Stem Cell Exhaustion	The incidence of invasive mold infections has increased during the 1990s among patients undergoing allogeneic hematopoietic stem cell transplantation (HCT) after myeloablative conditioning.	12689933
Multiple Myeloma	Stem Cell Exhaustion	High dose chemotherapy with autologous stem cell transplantation (ASCT) improves outcomes in patients 65 years of age or less with multiple myeloma.	12691140
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We evaluated the influence of cyclosporin A (CsA) used alone or together with the new purine nucleoside analogues (PNAs) 2-chlorodeoxyadenosine (2-CdA) and fludarabine (F-ara-A) on the colony growth of normal and chronic myelogenous leukemia (CML) granulocyte-macrophage progenitor cells (CFU-GM) in cultures in vitro.	12691305
Experimental Organism Basal Cell Carcinoma, Neoplasms	Stem Cell Exhaustion	The concurrent development of MCC, squamous-cell and basal-cell carcinoma in the same patient indicates the pluripotent epidermal stem cell origin of these tumors.	12692363
Malignant Neoplasms	Stem Cell Exhaustion	Comparative pharmacokinetic study of high-dose etoposide and etoposide phosphate in patients with lymphoid malignancy receiving autologous stem cell transplantation.	12692603
Hematologic Neoplasms	Stem Cell Exhaustion	The pharmacokinetics of two etoposide (E) formulations were evaluated in patients with refractory hematologic malignancies receiving high-dose conditioning with autologous stem cell transplantation.	12692603
Lymphoma	Stem Cell Exhaustion	An EBMT registry matched study of allogeneic stem cell transplants for lymphoma: allogeneic transplantation is associated with a lower relapse rate but a higher procedure-related mortality rate than autologous transplantation.	12692607
Malignant Glioma	Stem Cell Exhaustion	High-dose BCNU followed by autologous hematopoietic stem cell transplantation in supratentorial high-grade malignant gliomas: a retrospective analysis of 114 patients.	12692621
Toxic effect	Stem Cell Exhaustion	This dose-limiting toxicity can be circumvented by using autologous blood stem cell rescue.	12692621
Glioma	Stem Cell Exhaustion	We report our experience of high-dose BCNU followed by transplantation of autologous hematopoietic stem cells in 114 patients with high-grade gliomas.	12692621
Carcinogenesis	Stem Cell Exhaustion	Progenitor cells within the prostate basal layer may play important roles in differentiation and carcinogenesis; however, prostate stem cell populations remain uncharacterized.	12692787
Neoplasms	Stem Cell Exhaustion	[Cyclosporin A withdrawal causes spontaneous remission of recurrent subcutaneous tumors after allogeneic peripheral blood stem cell transplantation for adult T-cell leukemia/lymphoma].	12692982
Graft-vs-Host Disease, Hematologic Neoplasms	Stem Cell Exhaustion	Impact of graft-versus-host disease in reduced-intensity stem cell transplantation (RIST) for patients with haematological malignancies.	12694252
Graft-vs-Host Disease	Stem Cell Exhaustion	To clarify the impact of graft-versus-host disease (GVHD) on the outcome of reduced-intensity stem cell transplantation (RIST), 40 patients who received RIST were compared with those who received conventional stem cell transplantation (CST).	12694252
Myeloid Leukemia	Stem Cell Exhaustion	Allogeneic stem-cell transplantation from related and unrelated donors in older patients with myeloid leukemia.	12697870
Thrombomodulin Alfa, Thrombotic Microangiopathies, Vascular Diseases	Stem Cell Exhaustion	This case may be vasculopathy distinct from thrombotic microangiopathy (TMA) or a variant form of TMA following blood stem cell transplantation (BSCT).	12700971
Mastocytosis, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Chronic myeloproliferative disorder, Myelodysplastic-Myeloproliferative Diseases, Myeloid neoplasm, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The majority of patients with systemic mastocytosis with associated clonal, hematological non-mast cell lineage disease (SM-AHNMD) have a myeloid stem cell malignancy including myelodysplastic syndromes (MDS), myelodysplastic/myeloproliferative disorders, acute myeloid leukemia (AML), or chronic myeloproliferative disease.	12701114
Subcutaneous panniculitis-like T-cell lymphoma	Stem Cell Exhaustion	Subcutaneous panniculitis-like T-cell lymphoma during pregnancy with successful autologous stem cell transplantation.	12707721
Aggressive Non-Hodgkin Lymphoma, Toxic effect	Stem Cell Exhaustion	In a preliminary analysis of a study in 50 patients with refractory or relapsed aggressive lymphoma, rituximab plus etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin (EPOCH) chemotherapy has demonstrated promising results when used as sole salvage therapy and as an induction therapy prior to autologous stem-cell transplantation, again without significant additional toxicity.	12710590
Hematologic Neoplasms	Stem Cell Exhaustion	Autologous transplantation of granulocyte colony-stimulating factor-primed bone marrow is effective in supporting myeloablative chemotherapy in patients with hematologic malignancies and poor peripheral blood stem cell mobilization.	12714501
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic compared with autologous stem cell transplantation in the treatment of patients younger than 46 years with acute myeloid leukemia (AML) in first complete remission (CR1): an intention-to-treat analysis of the EORTC/GIMEMAAML-10 trial.	12714526
Corneal Opacity	Stem Cell Exhaustion	Incursion of goblet cells suggests impaired function of Pax6(+/-) limbal stem cells, abnormal expression of cytokeratin 12 may result in greater epithelial fragility, and corneal opacities in older mice may reflect poor wound-healing responses to accumulated environmental insults.	12714618
Multiple Myeloma	Stem Cell Exhaustion	High dose chemotherapy followed by autologous haemopoietic stem cell transplant in multiple myeloma.	12715951
Multiple Myeloma	Stem Cell Exhaustion	High dose chemotherapy followed by autologous stem cell transplant is currently used for the treatment of patients with advanced multiple myeloma.	12715951
Multiple Myeloma	Stem Cell Exhaustion	Fifty patients with advanced multiple myeloma underwent treatment with high dose melphalan followed by autologous stem cell transplant (bone marrow: 7; peripheral blood stem cells: 43).	12715951
Multiple Myeloma	Stem Cell Exhaustion	High dose melphalan followed by autologous stem cell transplantation is an effective treatment for patients with advanced multiple myeloma and achievement of complete response is associated with improved survival.	12715951
Multiple Myeloma	Stem Cell Exhaustion	Allogeneic stem cell transplantation (allo-SCT) after reduced-intensity conditioning was evaluated in 22 patients (median age 53, range 36-66 years) with multiple myeloma with progression after an autologous SCT.	12716363
Refractory Disease, Stable chronic Graft vs Host Disease	Stem Cell Exhaustion	Chemorefractory disease prior to allogeneic stem cell transplantation (P = 0.0182) and absence of cGVHD (P = 0.069) were associated with shorter event-free survival.	12716363
Peripheral Blood Stem Cells, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	A 64-year-old man with non-Hodgkin's lymphoma underwent peripheral blood stem cell (PBSC) collection.	12717792
Carcinoid tumor of lung, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Occurrence of a pulmonary carcinoid following allogeneic stem cell transplantation for chronic myelogenous leukemia: a case report.	12719884
Carcinoid tumor of lung, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We report the case of a 50-year-old woman who was diagnosed with a pulmonary carcinoid in 2001 after having undergone allogeneic stem cell transplantation for chronic myeloid leukemia (CML) in 1997.	12719884
Primary central nervous system lymphoma	Stem Cell Exhaustion	Successful treatment with reduced-intensity stem cell transplantation in a case of relapsed refractory central nervous system lymphoma.	12719887
Primary central nervous system lymphoma	Stem Cell Exhaustion	A 33-year-old male with refractory relapsed central nervous system lymphoma underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) from an HLA-identical sibling after reduced-intensity conditioning chemotherapy.	12719887
Cardiotoxicity	Stem Cell Exhaustion	This paper reviews the currently available options for reducing the cardiotoxicity of anthracyclines, the role of growth factors and autologous stem cell transplantation in dose-intensification of chemotherapy and also examines the clinical impact of the more promising new agents.	12722876
Non-Seminomatous Lesion, Embryonal Carcinoma	Stem Cell Exhaustion	Some types of GCT, i.e., the seminomas/germinomas/dysgerminomas and embryonal carcinomas (the stem cell component of nonseminomas), have pluripotent potential, which is demonstrated by their capacity to differentiate into somatic and/or extraembryonic elements.	12727846
Spermatocytic seminoma, Neoplasms, Dermoid Cyst, Teratoma	Stem Cell Exhaustion	The other types of GCT (teratomas and yolk sac tumors of infants and newborn, dermoid cyst of the ovary, and spermatocytic seminoma of elderly) are composed of (fully) differentiated tissues and lack the appearance of undifferentiated and pluripotent stem cells.	12727846
Secondary Acute Myeloid Leukemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic stem cell transplantation after a fludarabine/busulfan-based reduced-intensity conditioning in patients with myelodysplastic syndrome or secondary acute myeloid leukemia.	12728337
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We report the feasibility and efficacy of a fludarabine/busulfan-based dose-reduced conditioning regimen followed by stem cell transplantation from related ( n=19) or unrelated HLA-matched donors ( n=18) in 37 patients with myelodysplastic syndrome (MDS) or secondary acute myeloid leukemia (sAML) who were not eligible for a standard myeloablative conditioning regimen.	12728337
Communicable Diseases	Stem Cell Exhaustion	Transplantation of related histocompatible marrow and peripheral blood stem cells in a patient with severe combined immunodeficiency and disseminated BCG infection.	12728979
Multiple Myeloma	Stem Cell Exhaustion	166Ho-DOTMP plus melphalan followed by peripheral blood stem cell transplantation in patients with multiple myeloma: results of two phase 1/2 trials.	12730103
Multiple Myeloma	Stem Cell Exhaustion	In patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation two phase 1/2 dose-escalation studies of high-dose 166Ho-DOTMP plus melphalan were conducted.	12730103
Infections, Hospital	Stem Cell Exhaustion	Surveillance of nosocomial infections in adult recipients of allogeneic and autologous bone marrow and peripheral blood stem-cell transplantation.	12732887
Neutropenia, Infections, Hospital	Stem Cell Exhaustion	To identify overall and site-specific rates of nosocomial infections (NIs) during the neutropenic, as compared to the non-neutropenic stage of treatment in adult recipients of allogeneic and autologous bone marrow transplantation (BMT) and peripheral blood stem-cell transplantation (PBSCT), a prospective, 54-month study was started at the Haematological Stem Cell Transplantation Unit of the University Hospital of Freiburg, Germany.	12732887
Hepatitis A, Loss	Stem Cell Exhaustion	Loss of hepatitis A virus (HAV) antibodies after peripheral stem cell transplantation (PSCT).	12732889
cross immunity	Stem Cell Exhaustion	Peripheral stem cell transplantation (PSCT) is associated with loss of immunity.	12732889
Hodgkin Disease, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	We have treated 38 transplant-eligible patients with relapsed/refractory non-Hodgkin's lymphoma and Hodgkin's disease using an outpatient-based regimen of ifosfamide, carboplatin and etoposide (ICE) for both salvage and peripheral blood stem cell mobilisation.	12736225
Lymphoma, Follicular	Stem Cell Exhaustion	A total of 30 patients have undergone autologous stem cell transplantation(SCT) while two follicular lymphoma patients have received a non-myeloablative allogeneic SCT.	12736225
Primary Cutaneous B-Cell Non-Hodgkin Lymphoma	Stem Cell Exhaustion	A phase I-II study of rituximab, ifosfamide, mitoxantrone and etoposide (R-IME) for B cell non-Hodgkin's lymphoma prior to and after high-dose chemotherapy and autologous stem cell transplantation (HDC-ASCT).	12736227
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	This phase I-II study describes the safety of rituximab, ifosfamide, mitoxantrone and etoposide (R-IME) as an induction regimen prior to high-dose chemotherapy and autologous stem cell transplantation (HDC-ASCT), and rituximab given post-HDC-ASCT for B cell non-Hodgkins's lymphoma.	12736227
Infection, Neoplastic Stem Cells	Stem Cell Exhaustion	There was a significant decline in stem cell tumor cell contamination and a significant decline in IgG without an increase in infections.	12736227
Toxic effect, Lymphoma	Stem Cell Exhaustion	There appears to be a reduction in the number of lymphoma cells in the stem cell product and the toxicity is manageable.	12736227
Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma.	12736280
Specialty Type - cancer	Stem Cell Exhaustion	High-dose therapy with supporting autologous stem-cell transplantation remains a controversial treatment for cancer.	12736280
Multiple Myeloma	Stem Cell Exhaustion	In this multicenter study, the Medical Research Council Myeloma VII Trial, we randomly assigned 407 patients with previously untreated multiple myeloma who were younger than 65 years of age to receive either standard conventional-dose combination chemotherapy or high-dose therapy and an autologous stem-cell transplant.	12736280
Multiple Myeloma	Stem Cell Exhaustion	High-dose therapy with autologous stem-cell rescue is an effective first-line treatment for patients with multiple myeloma who are younger than 65 years of age.	12736280
Hematologic Neoplasms, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myeloid leukemia (CML) is a hematological neoplasia that results from the transformation of a hematopoietic stem cell.	12745649
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Autologous peripheral blood stem cell transplantation in first remission adult acute myeloid leukaemia--an intention to treat analysis and comparison of outcome using a predictive model based on the MRC AML10 cohort.	12745657
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The role of autologous peripheral blood stem cell transplantation (APBSCT) in acute myeloid leukaemia (AML) remains controversial.	12745657
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Role of pretransplant interferon-alpha(IFN) treatment in the outcome of stem cell transplantation (SCT) from related donors in chronic myelogenous leukemia (CML): results from three Turkish transplant centers.	12748666
Graft-vs-Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	The incidences of acute or chronic graft-versus-host disease (GVHD), relapse and graft failure were similar in all patients regardless of stem cell source.	12748666
Pancreatic Neoplasm	Stem Cell Exhaustion	Regression of an unresectable pancreatic tumor following nonmyeloablative allogeneic peripheral-blood stem-cell transplantation.	12748675
Pancreatic Neoplasm	Stem Cell Exhaustion	A 59-year-old female with an unresectable, large pancreatic tumor (10.0 x 8.0 cm(2) on CT scan) underwent nonmyeloablative allogeneic peripheral-blood stem-cell transplantation from her HLA-identical sibling.	12748675
Pancreatic Neoplasm	Stem Cell Exhaustion	The observed clinical course may suggest a graft-versus-tumor effect on the pancreatic tumor following allogeneic stem-cell transplantation.	12748675
filgrastim, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Successful peripheral blood stem cell mobilisation with filgrastim in patients with chronic myeloid leukaemia achieving complete cytogenetic response with imatinib, without increasing disease burden as measured by quantitative real-time PCR.	12750692
Primary Myelofibrosis	Stem Cell Exhaustion	To determine whether R115777 might exert similar activity in myelofibrosis with myeloid metaplasia (MMM), we evaluated its effects on circulating myeloid progenitor cells from patients with MMM (n=25) using in vitro colony-forming assays.	12750696
Venoocclusive disease	Stem Cell Exhaustion	VOD is a severe complication in allogeneic stem cell or bone marrow transplantation.	12761649
Childhood Breast Carcinoma	Stem Cell Exhaustion	Predicting outcome based on Swenerton score in patients with metastatic breast cancer undergoing high-dose chemotherapy and autologous hematopoietic stem cell transplantation: implications for patient selection.	12766883
mecarzole, Childhood Breast Carcinoma	Stem Cell Exhaustion	The aim of this study was to study the effectiveness of the Swenerton score in assessing extent of disease as an independent prognostic and predictive factor in patients with metastatic breast cancer (MBC) who receive high-dose chemotherapy (HDCT) with autologous hematopoietic stem cell transplant (AHSCT).	12766883
Optic Neuritis, Meningitis	Stem Cell Exhaustion	Human herpesvirus 7-associated meningitis and optic neuritis in a patient after allogeneic stem cell transplantation.	12767008
Vomitus	Stem Cell Exhaustion	A 9-year-old boy who received allogeneic stem cell transplantation began to vomit from day 10 after transplantation.	12767008
T-Cell Lymphoma, Hepatic impairment	Stem Cell Exhaustion	Non-myeloablative hematopoietic stem cell transplantation for the treatment of adult T-cell lymphoma in a patient with advanced hepatic impairment.	12769349
Liver Cirrhosis, T-Cell Lymphoma, Hepatitis B	Stem Cell Exhaustion	A 59-year-old man with liver cirrhosis due to hepatitis B virus infection received non-myeloablative stem-cell transplantation (NST) for the treatment of adult T-cell lymphoma.	12769349
Urothelial Carcinoma	Stem Cell Exhaustion	Immunocytochemical analysis of prostate stem cell antigen as adjunct marker for detection of urothelial transitional cell carcinoma in voided urine specimens.	12771726
Carcinoma, Transitional Cell	Stem Cell Exhaustion	Prostate stem cell antigen (PSCA), a homologue of the Ly-6/Thy-1 family of cell surface antigens, has been shown to be increased in a majority of human transitional cell carcinomas.	12771726
HODGKINS AND NON-HODGKINS LYMPHOMA	Stem Cell Exhaustion	Correlation of early lymphocyte recovery and progression-free survival after autologous stem-cell transplant in patients with Hodgkin's and non-Hodgkin's Lymphoma.	12774052
Acute lymphocytic leukemia	Stem Cell Exhaustion	Successful T-cell-replete peripheral blood stem cell transplantation from HLA-haploidentical microchimeric mother to daughter with refractory acute lymphoblastic leukemia using reduced-intensity conditioning.	12774061
Acute lymphocytic leukemia	Stem Cell Exhaustion	A 16-year-old girl with refractory acute lymphoblastic leukemia underwent reduced-intensity hematopoietic stem cell transplantation from her two-locus-mismatched haploidentical mother, who was microchimeric for the patient's hematopoietic cells.	12774061
Graft-vs-Host Disease	Stem Cell Exhaustion	This successful experience suggests that maternal hematopoietic stem cell transplants for children, in the presence of microchimerism, may be associated with hyporesponsiveness to the inherited paternal HLA antigens (IPA); preventing severe GVHD.	12774061
Graft-vs-Host Disease	Stem Cell Exhaustion	Non-T-cell-depleted peripheral blood stem cells were infused with graft-versus-host disease (GVHD) prophylaxis consisting of tacrolimus, prednisolone, and short-course methotrexate.	12774061
Promyelocytes, Disseminated Intravascular Coagulation, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Rapid improvement of disseminated intravascular coagulation by donor leukocyte infusions in a patient with promyelocytic crisis of chronic myelogenous leukemia after reduced-intensity stem cell transplantation from an HLA 2-antigen-mismatched mother.	12774933
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Donor leukocyte infusion (DLI) is recognized as effective therapy for relapse after stem cell transplantation in patients with chronic myelogenous leukemia (CML).	12774933
Promyelocytes, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We describe a 22-year-old male patient with promyelocytic crisis of CML who had a relapse after peripheral blood stem cell transplantation, under reduced-intensity conditioning, from his HLA 2-antigen-mismatched mother.	12774933
SLC25A10 gene	Stem Cell Exhaustion	In addition, this may be the first report of effective correction of DIC by DLI after stem cell transplantation.	12774933
Malignant Neoplasms	Stem Cell Exhaustion	Long after the therapy, the instability may become an initiating event in the development of new malignancies in affected tissues, whereas the instability induced in haemopoietic stem cells may reveal itself in peripheral lymphocytes derived from formerly exposed precursors.	12775449
Retinoblastoma	Stem Cell Exhaustion	These results suggest that the retinoblastoma might be developed from visual stem cells, which are common progenitor cells of photoreceptor cells, intermediate neurons, and ganglion cells.	12777100
Parkinson Disease	Stem Cell Exhaustion	Here we provide evidence for the generation of dopaminergic projection neurons of the type that are lost in Parkinson's disease from stem cells in the adult rodent brain and show that the rate of neurogenesis is increased after a lesion.	12792021
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Although increasing the dose of imatinib can benefit a subgroup of patients with CML with either an inadequate cytogenetic response or disease progression, our results suggest the majority will not have a sustained meaningful response, and that other options, such as allogeneic stem cell transplant or investigational therapies, also need to be considered at the time of dose increase.	12796373
Febrile Neutropenia	Stem Cell Exhaustion	An open labeled randomized trial comparing the efficacy and cost of empirically applied cefepime (C) as monotherapy versus combination therapy consisting of ticarcillin and clavulanate potassium and aztreonam (T/A) was performed in febrile neutropenic patients following high-dose chemotherapy (HDC) +/- radiation, with or without peripheral blood stem cell support.	12796602
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Reduced intensity conditioning for allogeneic hematopoietic stem cell transplantation in patients with acute myeloid leukemia: disease status by marrow blasts is the strongest prognostic factor.	12796788
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We analyzed predictive factors for the outcome of 113 acute myeloid leukemia patients receiving reduced-intensity conditioning prior to allogeneic hematopoietic stem cell transplantation (HSCT).	12796788
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Normalization of previously shortened telomere length under treatment with imatinib argues against a preexisting telomere length deficit in normal hematopoietic stem cells from patients with chronic myeloid leukemia.	12799279
Lymphoma	Stem Cell Exhaustion	Poor mobilization of peripheral blood stem cells is a risk factor for worse outcome in lymphoma patients undergoing autologous stem cell transplantation.	12802919
Chronic Lymphocytic Leukemia, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The simultaneous occurrence of Philadelphia positive chronic myeloid leukemia (Ph+ CML) and B-cell chronic lymphocytic leukemia (B-CLL) is a rare event which raises the possibility that the two malignant clones derive from a common, or distinct, malignant stem cells.	12802927
Genus Erwinia	Stem Cell Exhaustion	We describe a patient with natural killer (NK)/T cell lymphoma who relapsed after autologous peripheral blood stem cell transplantation (auto-PBSCT) and was successfully treated with Escherichia coli (E. coli) and Erwinia L-asparaginase.	12802930
Pregnancy Complications, Infectious	Stem Cell Exhaustion	The purpose of this retrospective study was to evaluate infectious complications in patients receiving mobilization chemotherapy for stem cell collection prior to autologous peripheral blood stem cell transplantation.	12804174
Venoocclusive disease	Stem Cell Exhaustion	Homocysteine and prothrombin fragment 1+2 levels in patients with veno-occlusive disease after stem cell transplantation.	12804180
Venoocclusive disease	Stem Cell Exhaustion	Veno-occlusive disease (VOD) of the liver remains a major complication after hematopoietic stem cell transplantation (SCT).	12804180
Colorectal Carcinoma, Neoplasms, Stem Cell Factor	Stem Cell Exhaustion	Therefore, in the present study, we have investigated in colorectal cancer patients the serum levels of selected HGFs, such as stem cell factor (SCF), interleukin 3 (IL-3), granulocyte-macrophage-colony stimulating factor (GM-CSF), and M-CSF in relation to controls and to the classical tumor markers, such as carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) in colorectal cancer.	12812262
melanoma	Stem Cell Exhaustion	NG2 is the rat homologue of the human melanoma chondroitin sulfate proteoglycan (MCSP) preferentially expressed in dividing progenitor cells of the glial and mesenchymal lineage but downregulated after differentiation.	12812755
Lymphoma cells	Stem Cell Exhaustion	High-dose myeloablative therapy and autologous peripheral blood progenitor cell transplantation for elderly patients (greater than 65 years of age) with relapsed large cell lymphoma.	12813446
Toxic effect, Primary amyloidosis	Stem Cell Exhaustion	We hypothesized that the novel conditioning regimen of 550 cGy total body irradiation (TBI) alone for autologous peripheral blood stem cell transplantation would have reduced organ toxicity and thus permit safer transplantation of primary amyloidosis patients, even those with poor risk disease.	12813448
Specialty Type - cancer	Stem Cell Exhaustion	This study assessed the ability of various schedules of recombinant human thrombopoietin (rhTPO) to enhance mobilization of peripheral blood progenitor cells (PBPCs) in 134 patients with cancer undergoing high-dose chemotherapy and autologous PBPC transplantation.	12813449
Myeloproliferative disease, MVD gene	Stem Cell Exhaustion	An increase in colony-forming progenitor cells (CFU) is typically seen in myeloproliferative disorders (MPD).	12814399
Viral respiratory infection	Stem Cell Exhaustion	Respiratory viral infections after bone marrow/peripheral stem-cell transplantation: the Christie hospital experience.	12815481
Central neuroblastoma	Stem Cell Exhaustion	This case demonstrates the possibility of a graft-versus-tumor effect against neuroblastoma by HLA-mismatched allogeneic hematopoietic stem cell transplantation.	12815485
Immunocompromised Host	Stem Cell Exhaustion	Autologous stem cell transplantation recipients are significantly immunocompromised albeit temporarily.	12815488
Communicable Diseases	Stem Cell Exhaustion	Despite the increasing use of haemopoetic stem cell transplantation, hyperinfection with strongyloides has rarely been reported.	12815488
Neoplasms	Stem Cell Exhaustion	Immunohistochemical studies also revealed that the tumor cells expressed basic fibroblast-growth factor, vascular-endothelial-growth factor, and stem-cell factor, factors that may contribute to the rich vascularity and mast cells within the tumor.	12819396
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	[Successful attainment of the third chronic phase by autologous peripheral blood stem cell transplantation and imatinib in a patient with chronic myeloid leukemia].	12822405
Blast Phase	Stem Cell Exhaustion	This may be a rare case in which normal hematopoietic stem cells could be enriched in the peripheral blood in the accelerated phase, and that cytogenetic remission was achieved using these cells in the blast crisis.	12822405
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Flexible use of peripheral blood stem cells and imatinib could be an additional strategy for the better treatment of chronic myeloid leukemia.	12822405
Therapy-related myelodysplastic syndrome, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Therapy-related myelodysplasia and/or acute myeloid leukaemia after autologous haematopoietic progenitor cell transplantation in a prospective single centre cohort of 221 patients.	12823352
Therapy-related myelodysplastic syndrome, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	To evaluate the incidence and the predictive signs of therapy-related myelodysplasia and/or acute myeloid leukaemia (tMDS/tAML), we undertook a prospective study over a 4-year period of 221 patients who underwent autologous haematopoietic progenitor cell transplantation.	12823352
Ocular surface disease	Stem Cell Exhaustion	A 31-year-old woman presented with severe bilateral ocular surface disease with partial limbal stem cell deficiency, symblephara, lid and facial scarring, with a vision of 20/400 and counting fingers at 1 m in both eyes.	12827056
Multiple Myeloma	Stem Cell Exhaustion	Use of a supportive care team for screening and preemptive intervention among multiple myeloma patients receiving stem cell transplantation.	12827482
Multiple Myeloma	Stem Cell Exhaustion	Although peripheral blood stem-cell transplantation (PBSCT) has assumed a growing role in the treatment of multiple myeloma, very few studies have examined the functional and quality-of-life changes experienced by myeloma patients in the transplant setting.	12827482
Multiple Myeloma	Stem Cell Exhaustion	Busulfan, cyclophosphamide, and etoposide as conditioning for autologous stem cell transplantation in multiple myeloma.	12827653
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) has enabled the use of high-dose alkylating agents either as a single agent or in combination with other cytotoxic agents and/or total body irradiation (TBI) for the treatment of multiple myeloma.	12827653
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Marrow versus peripheral blood for geno-identical allogeneic stem cell transplantation in acute myelocytic leukemia: influence of dose and stem cell source shows better outcome with rich marrow.	12829583
Adult Stem Cells, Polycythemia Vera, Myeloproliferative disease, Myeloid Proliferation Index	Stem Cell Exhaustion	Polycythemia vera (PV) is a myeloproliferative disorder due to an unknown somatic stem cell defect that leads to clonal myeloid hyperproliferation.	12829587
Central neuroblastoma	Stem Cell Exhaustion	Seventy-five children older than 1 year and with stage IV neuroblastoma had 123I-MIBG scans at diagnosis, after two and four cycles of induction therapy, and before autologous stem-cell transplantation.	12829667
Graft-vs-Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	There have been no detailed analyses of the induction of donor cell-type chimerism, the onset and incidence of acute and chronic graft-versus-host disease (GVHD), and the immune recovery kinetics after reduced-intensity stem cell transplantation (RIST).	12829926
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Effect of rituximab on peripheral blood stem cell mobilization and engraftment kinetics in non-Hodgkin's lymphoma patients.	12838277
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin, Neoplasms	Stem Cell Exhaustion	Rituximab is used for in vivo tumor cell purging for non-Hodgkin's lymphoma (NHL) patients prior to autologous peripheral blood stem cell transplantation (PBSCT).	12838277
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Two patients autografted for multiple myeloma (MM) showed delayed neutrophil and platelet engraftment despite receiving an adequate dose of stem cells.	12838285
Testicular Plasmacytoma	Stem Cell Exhaustion	We suggest that early use of combined chemoradiotherapy and high-dose chemotherapy with autologous stem cell support should be investigated in patients with testicular plasmacytoma with dissemination.	12838369
Gastrointestinal Stromal Tumors	Stem Cell Exhaustion	Both GIST and GIST type ST beyond the gastrointestinal tract are considered originating from a proto-interstitial stem cell with disoriented differentiation.	12839670
Myeloid neoplasm	Stem Cell Exhaustion	Reduced-intensity conditioning for unrelated donor hematopoietic stem cell transplantation as treatment for myeloid malignancies in patients older than 55 years.	12842990
Myeloid neoplasm	Stem Cell Exhaustion	Hematopoietic stem cell transplantation from unrelated donors is an effective treatment for myeloid malignancies, but its use is usually restricted to young patients without comorbidities.	12842990
Graft-vs-Host Disease	Stem Cell Exhaustion	We analyzed the factors affecting recovery of cytomegalovirus (CMV)-specific CD4+ and CD8+ function at 3 months after HSCT by univariate and multivariable analyses including source of stem cells (bone marrow vs peripheral blood stem cells [PBSCs]), age, sex, graft-versus-host disease (GVHD), steroid use, conditioning regimens, ganciclovir use, HLA matching, circulating CMV antigenemia, absolute CD4+ and CD8+ counts, and donor CMV serology.	12843000
Stem Cell Factor	Stem Cell Exhaustion	Autocrine and paracrine secretion of angiogenic and hematopoietic growth factors such as vascular endothelial growth factor (VEGF) and stem cell factor (SCF) in the bone marrow microenvironment may promote proliferation and survival of leukemic blasts.	12843001
Hematopoietic Neoplasms, PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is a common neoplasm of haematopoietic pluripotent stem cells.	12846890
Aplastic Anemia	Stem Cell Exhaustion	Direct binding of antithymoctye globulin to haemopoietic progenitor cells in aplastic anaemia.	12846899
Aplastic Anemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Successful bone marrow plus cord blood stem cell transplantation in a girl who developed myelodysplastic syndrome from hepatitis-associated aplastic anemia treated with long-term immunosuppressants and growth factors.	12850817
Polycythemia Vera	Stem Cell Exhaustion	Structural, antigenetic and transcriptional characteristics in peripheral blood CD34+ progenitor cells from polycythemia vera patients: evidence for delayed determination.	12851693
Gastrointestinal Stromal Tumors, Neoplasms	Stem Cell Exhaustion	Gastrointestinal stromal tumors (GISTs) are a group of neoplasms arising from mesenchymal stem cells of the gastrointestinal tract.	12851843
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	The role of high dose therapy, including autologous stem cell transplantation (ASCT) in indolent non-Hodgkin's lymphomas remains controversial.	12854895
Idiopathic pneumonia syndrome	Stem Cell Exhaustion	Risks and outcomes of idiopathic pneumonia syndrome after nonmyeloablative and conventional conditioning regimens for allogeneic hematopoietic stem cell transplantation.	12855568
Idiopathic pneumonia syndrome, Hemopoietic stem cell transplant	Stem Cell Exhaustion	Idiopathic pneumonia syndrome (IPS) is a significant noninfectious complication of hematopoietic stem cell transplantation (HSCT).	12855568
Graft-vs-Host Disease, Mycoses	Stem Cell Exhaustion	Infliximab use in patients with severe graft-versus-host disease and other emerging risk factors of non-Candida invasive fungal infections in allogeneic hematopoietic stem cell transplant recipients: a cohort study.	12855583
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease (GVHD) is a common complication of allogeneic hematopoietic stem cell transplantation (HSCT).	12855583
Amyotrophic Lateral Sclerosis, Antilymphocyte Serum	Stem Cell Exhaustion	Amyotrophic lateral sclerosis (ALS), a multifactorial disease characterized by diffuse motor neuron degeneration, has proven to be a difficult target for stem cell therapy.	12857367
Childhood Breast Carcinoma	Stem Cell Exhaustion	Micrometastases in apheresis products predict shorter progression-free and overall survival in patients with breast cancer undergoing high-dose chemotherapy (HDCT) and autologous blood stem cell transplantation (ABSCT).	12858203
Childhood Breast Carcinoma	Stem Cell Exhaustion	Data from 83 patients with breast cancer treated with autologous blood stem cell transplantation were analyzed.	12858203
Crohn Disease	Stem Cell Exhaustion	Complete remission of Crohn's disease after high-dose cyclophosphamide and autologous stem cell transplantation.	12858208
Lameness, Ulcer	Stem Cell Exhaustion	Three months after the first stem cell transplantation, severe pain lameness, local cool-feeling and ulcer were improved, and ABI increased from 0.49, 0.69 to 0.50, 0.85, the amplitude of blood flow and laser Doppler blood perfusion were also significantly improved (P < 0.01).	12859867
Arteriosclerosis Obliterans	Stem Cell Exhaustion	[Transplantation of autologous peripheral blood stem cells for the treatment of lower limb arteriosclerosis obliterans].	12859867
Arteriosclerosis Obliterans	Stem Cell Exhaustion	To evaluate the clinical efficacy of mobilized autologous peripheral blood stem cells (PBSC) transplantation in a 48 years old patient with lower limb arteriosclerosis obliterans (ASO).	12859867
Neoplasms	Stem Cell Exhaustion	Quantitative assessment of contaminating tumor cells in autologous peripheral blood stem cells of B-cell non-Hodgkin lymphomas using immunoglobulin heavy chain gene allele-specific oligonucleotide real-time quantitative-polymerase chain reaction.	12860013
Chickenpox	Stem Cell Exhaustion	Another 18-year-old male suffered from varicella 16 months after the complete engraftment of hematopoietic stem cell transplantation.	12860147
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Evidence of a graft-versus-leukemia effect in chronic lymphocytic leukemia after reduced-intensity conditioning and allogeneic stem-cell transplantation: the Cooperative German Transplant Study Group.	12860954
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	To study whether hematopoietic stem-cell transplantation (HSCT) after reduced-intensity conditioning is effective and tolerable in patients with advanced chronic lymphocytic leukemia (CLL).	12860954
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukemia (AML) is a clonal disease of hematopoiesis with poor clinical outcome despite recent improvements in chemotherapy and stem cell transplantation regimens.	12862419
Cytopenia	Stem Cell Exhaustion	The category and the positive rate of autoantibodies on bone marrow hematopoietic stem cells, nucleated erythrocytes, granulocytes in 32 patients with uncertain immunorelated cytopenia were investigated by using BMMNC-Coombs test and double immunofluorescence flow cytometry.	12864946
Pancytopenia	Stem Cell Exhaustion	91.3% of the patients had autoantibodies on bone marrow hematopoietic stem cells and showed pancytopenia, and 50% of the patients had autoantibodies on nucleated erythrocytes and granulocytes.	12864946
immunoglobulin A	Stem Cell Exhaustion	The quantity of IgA on hematopoietic stem cells was significantly higher than that on nucleated erythrocytes or granulocytes.	12864946
Pancytopenia, Cytopenia	Stem Cell Exhaustion	Most immunorelated cytopenia patients had autoantibodies on hematopoietic stem cells and showed pancytopenia.	12864946
immunoglobulin A	Stem Cell Exhaustion	IgA was more easily seen on the hematopoietic stem cells.	12864946
Graft-vs-Host Disease, Toxic effect	Stem Cell Exhaustion	Graft-versus-host disease, donor chimerism, and organ toxicity in stem cell transplantation after conditioning with fludarabine and melphalan.	12869957
Malignant Neoplasms	Stem Cell Exhaustion	Hematopoietic stem cell transplantation may be used to induce a graft-versus-tumor effect against a range of malignancies.	12869957
Hematologic Neoplasms	Stem Cell Exhaustion	An expanded phase I/II trial of cyclophosphamide, etoposide, and carboplatin plus total body irradiation with autologous marrow or stem cell support for patients with hematologic malignancies.	12869958
Failure, Hematologic Neoplasms	Stem Cell Exhaustion	The major cause for failure of autologous stem cell transplantation for hematologic malignancies is the risk of recurrent disease.	12869958
Neutropenia	Stem Cell Exhaustion	Neutropenia was present in 83% and 33 patients had undergone stem cell transplantation.	12872351
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Rituximab reduces relapse risk after allogeneic and autologous stem cell transplantation in patients with high-risk aggressive non-Hodgkin's lymphoma.	12877674
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	High-dose chemotherapy and autologous stem cell transplantation (SCT) have limited success in patients with refractory aggressive lymphoma.	12877674
Enlargement procedure	Stem Cell Exhaustion	Because the bone marrow (BM) contains mesangial cell progenitors that can transfer the donor glomerular phenotype (normal or diseased) to recipients, we exchanged BM between postmenopausal and premenopausal mice and found that aging-related glomerular enlargement and scarring are transferred to young recipient glomeruli.	12878780
Kidney Diseases, Renal glomerular disease	Stem Cell Exhaustion	Thus, aging-related glomerular disease is an entity distinct from all other causes of renal disease, is characterized by phenotypic changes in mesangial cell progenitors, and is reversible when the phenotype of the progenitors is returned to normal.	12878780
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	In the present study, we examined the HLA-A, -B, and -DRB1/3/4/5 allele and haplotype distributions in Turkish CML patients diagnosed in a single center where they are routinely HLA-typed by PCR-SSP analysis as a preparation for stem cell transplantation.	12879429
Hematologic Neoplasms	Stem Cell Exhaustion	The aim of this retrospective study was to investigate the feasibility of high-dose therapy (HDT) followed by peripheral blood stem cell transplantation (PBSCT) in elderly patients with hematological malignancies.	12879431
Toxic effect, Lymphoma, Non-Hodgkin, Multiple Myeloma	Stem Cell Exhaustion	Feasibility and toxicity of high-dose therapy (HDT) supported by peripheral blood stem cells in elderly patients with multiple myeloma and non-Hodgkin's lymphoma: survey from a single institution.	12879431
Blast Phase	Stem Cell Exhaustion	[Successful induction of complete cytogenetic response with high-dose imatinib mesylate and subsequent allogeneic stem cell transplantation for CML blastic crisis].	12884817
Hemolytic-Uremic Syndrome, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	[Hemolytic uremic syndrome-like episode following nonmyeloablative hematopoietic stem cell transplantation in a patient with chronic myeloid leukemia].	12884818
Hemolytic-Uremic Syndrome, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We report on a 61-year-old woman with chronic myeloid leukemia (CML) who developed a hemolytic uremic syndrome (HUS)-like episode following nonmyeloablative allogeneic hematopoietic stem cell transplantation.	12884818
Kidney Failure, Microscopic hematuria, Anemia, Hemolytic, Decreased platelet count, Hypertension, CTCAE	Stem Cell Exhaustion	Macrohematuria, hypertension, hemolytic anemia with red cell fragmentation, thrombocytopenia, and progressive renal insufficiency were observed after thawed peripheral blood stem cell (PBSC) infusion.	12884818
Hemolysis (biological function), Hemolytic-Uremic Syndrome	Stem Cell Exhaustion	Although transient systemic hemolysis is known to occur during dimethylsulfoxide (DMSO)-cryopreserved stem cell infusion, HUS caused by DMSO has not been described in the literature.	12884818
Cerebral Small Vessel Diseases	Stem Cell Exhaustion	We speculate that one of the triggers of the HUS-like episode could have been renal microangiopathy caused by the long-term administration of interferon-alpha before the stem cell transplantation.	12884818
Acute leukemia	Stem Cell Exhaustion	In view of the recent reports demonstrating delayed engraftment after autologous and allogeneic transplantation from donors with constitutional pericentric inversion of chromosome 9, [inv(9)], we conducted a retrospective study on six patients with acute leukemia and inv(9) to investigate if there is an impaired engraftment potential of the inv(9) hematopoietic stem cells.	12885469
Peripheral Stem Cell Transplantation, Anorexia, Nausea, Diarrhea, Have Been Vomiting, Sleep disturbances	Stem Cell Exhaustion	The study results indicate that patients undergoing peripheral blood stem cell transplantation experience significant appetite loss (P <.01), diarrhea (P <.05), nausea and vomiting (P <.05), and sleep disturbances (P <.01) during the acute posttransplantation period.	12886122
Acute lymphocytic leukemia	Stem Cell Exhaustion	Risk assessment in adult acute lymphoblastic leukaemia before early haemopoietic stem cell transplantation with a geno-identical donor: an easy clinical prognostic score to identify patients who benefit most from allogeneic haemopoietic stem cell transplantation.	12886248
Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	After a partial response was achieved by irradiation (40 Gy) and high-dose chemotherapy (carboplatin and etoposide) with peripheral blood stem cell transplantation, the patient underwent surgery with a wide excision of the psoas muscle.	12887367
Multiple Myeloma	Stem Cell Exhaustion	Granular lymphocyte proliferative disorder after autologous peripheral blood stem cell transplantation for multiple myeloma.	12890152
Multiple Myeloma	Stem Cell Exhaustion	A 57-yr-old woman with multiple myeloma underwent tandem autologous peripheral blood stem cell transplantation (APBSCT).	12890152
Heart failure	Stem Cell Exhaustion	[Mobilization of bone marrow stem cells in the management of patients with heart failure.	12891252
Lymphoma, Follicular	Stem Cell Exhaustion	Comparison of autologous and allogeneic hematopoietic stem cell transplantation for follicular lymphoma.	12893748
Neoplasms, Malignant neoplasm of gastrointestinal tract	Stem Cell Exhaustion	Detection of circulating tumor cells by cytokeratin 20 and prostate stem cell antigen RT-PCR in blood of patients with gastrointestinal cancers.	12894563
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	The present study aimed to examine whether cytokeratin 20 (CK-20) and prostate stem cell antigen (PSCA) are useful markers for the detection of disseminated cancer cells in the blood of tumor patients.	12894563
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Successful reduced-intensity stem cell transplantation from an HLA haploidentical 3-loci-mismatched donor on the basis of fetomaternal microchimerism in a patient with advanced acute myeloid leukemia.	12894854
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 31-year-old woman with advanced acute myeloid leukemia underwent non-T-cell-depleted (TCD) peripheral blood stem cell transplantation (PBSCT) with a reduced-intensity conditioning regimen.	12894854
Neoplasms	Stem Cell Exhaustion	The mutant c-Kit proteins, which are activated without a stem cell factor, contribute to the tumor development.	12898363
Virus Diseases	Stem Cell Exhaustion	Patients treated with purine analogues or autologous stem cell transplantation had a higher risk of developing viral infections.	12899715
Lymphoma	Stem Cell Exhaustion	[Treatment of malignant lymphoma by autologous hematopoietic stem cell transplantation combined with high dose radiotherapy and chemotherapy].	12899794
Lymphoma	Stem Cell Exhaustion	To investigate the effects of treatment of malignant lymphoma (ML) by autologous hematopoietic stem cell transplantation (AHSCT) combined with high dose radiotherapy and chemotherapy.	12899794
Specialty Type - cancer	Stem Cell Exhaustion	Decreased expression of stem cell factor in esophageal and gastric mucosa after esophagogastric anastomosis for cancer: potential relevance to motility.	12900372
Graft-vs-Host Disease, Psoriasis	Stem Cell Exhaustion	Induction of graft-versus-autoimmune (GVA) disease effect against refractory psoriasis by complete donor-type chimerism and graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.	12900783
Esophageal	Stem Cell Exhaustion	Esophageal actinomycosis after allogeneic peripheral blood stem cell transplantation for extranodal natural killer/T cell lymphoma, nasal type.	12900786
Cervical Intraepithelial Neoplasia	Stem Cell Exhaustion	These findings confirm and extend our previous observations in flow-cytometric studies of apoptosis in CIN, indicating that increased apoptosis in CIN bone marrow concerns mainly the CD34(+) and CD34(+)/CD33(+) progenitor cell compartments.	12904900
Chronic idiopathic neutropenia	Stem Cell Exhaustion	Increased cell apoptosis in bone marrow trephine biopsies and immunomagnetically isolated myeloid progenitor cells in patients with chronic idiopathic neutropenia.	12904900
Cervical Intraepithelial Neoplasia, Chronic idiopathic neutropenia	Stem Cell Exhaustion	The frequency of apoptotic cells in bone marrow trephine biopsies and cytospins of immunomagnetically isolated myeloid progenitor cells was determined in 39 patients with chronic idiopathic neutropenia (CIN) and 12 hematologically normal individuals using the in situ end-labeling (ISEL) apoptosis detection method.	12904900
Graft-vs-Host Disease	Stem Cell Exhaustion	CD25 expression on donor CD4+ or CD8+ T cells is associated with an increased risk for graft-versus-host disease after HLA-identical stem cell transplantation in humans.	12907445
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Value of F-18 fluorodeoxyglucose positron emission tomography for predicting the clinical outcome of patients with aggressive lymphoma prior to and after autologous stem-cell transplantation.	12907550
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	To determine and compare the values of positron emission tomography (PET) with F-18 fluorodeoxyglucose (FDG) and CT for predicting clinical outcome of patients with aggressive lymphoma undergoing salvage cytoreductive chemotherapy followed by high-dose chemotherapy and autologous stem-cell transplantation (ASCT).	12907550
Bone marrow hypocellularity, Thrombosis, Chronic hemolytic anemia, Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria	Stem Cell Exhaustion	Paroxysmal nocturnal haemoglobinuria (PNH) is an acquired haemopoietic stem cell disorder characterised clinically by chronic haemolytic anaemia with acute episodes, thrombosis and bone marrow failure.	12916545
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	High-dose chemotherapy supported by autologous stem cell transplantation is widely used in patients with non-Hodgkin's lymphoma (NHL).	12916867
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	We therefore analysed regimen-related toxicity and outcome in 71 consecutive NHL patients who received either BEAC (N = 36) or BEAM (N = 35) supported by peripheral blood progenitor cell infusion plus granulocyte colony-stimulating factor.	12916867
Conjunctival intraepithelial neoplasia, Burn injury	Stem Cell Exhaustion	Five eyes of five patients with total limbal stem cell deficiency (LSCD) resulting from pseudopemphigoid (n = 1), chemical burns (n = 3), and extensive removal of conjunctival intraepithelial neoplasia (n = 1) were operated on by one surgeon (SCGT).	12917178
Primary Myelofibrosis	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation for myelofibrosis.	12920019
Cytomegalovirus Infections	Stem Cell Exhaustion	Risk for cytomegalovirus infection following reduced intensity allogeneic stem cell transplantation.	12920570
Pregnancy Complications, Infectious	Stem Cell Exhaustion	Preliminary data suggest a faster immune recovery following non-myeloablative stem cell transplantation because of the persistence of recipient T cells, but the real impact on post-transplant infectious complications remains unknown.	12920570
Hematological Disease, Hemolytic-Uremic Syndrome, Additional, Unknown (origin) (qualifier value), Thrombomodulin Alfa, Diarrhea, Neoplasms	Stem Cell Exhaustion	Patients were assigned to ten predefined clinical categories according to information provided in the referral letter (TMA not specified; TMA associated with neoplasia or chemotherapy; TMA following haematopoietic stem cell transplantation; TMA with additional disorder; idiopathic TTP; haemolytic-uraemic syndrome (HUS) not specified; HUS with diarrhoea prodrome; atypical HUS; other haematological disorder; no clinical information available).	12923683
Hepatitis B	Stem Cell Exhaustion	Successful clearance of hepatitis B virus after allogeneic stem cell transplantation: beneficial combination of adoptive immunity transfer and lamivudine.	12930325
Hepatitis B	Stem Cell Exhaustion	The patient underwent allogeneic peripheral blood stem cell transplantation (PBSCT) from his sibling who was hepatitis B surface antibody (HBsAb) positive.	12930325
Anemia, Sickle Cell, Thalassemia	Stem Cell Exhaustion	We describe previously transfused patients with sickle cell disease (n = 6) and thalassemia (n = 1) who received nonmyeloablative hematopoietic stem cell transplantation (HCT) to induce stable (full or partial) donor engraftment.	12931121
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Long-term outcome of autologous transplantation of peripheral blood progenitor cells as postremission management of adult acute myelogenous leukemia in first complete remission.	12931210
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In order to improve leukemia-free survival (LFS) without the treatment-related morbidity of allogeneic bone marrow transplantation or multiple prolonged cycles of consolidation chemotherapy, we evaluated the long-term outcome of autologous transplantation of peripheral blood progenitor cells (PBPCs) as postremission therapy in 129 patients aged 18-71 years (median 49 years) with newly diagnosed acute myelogenous leukemia (AML) in first complete remission (CR1).	12931210
Infection	Stem Cell Exhaustion	In the setting of reduced-intensity conditioning (RIC) regimens for allogeneic stem cell transplantation (allo-SCT), the epidemiology of transplant-related infections is still poorly defined.	12931226
Bacteremia	Stem Cell Exhaustion	In multivariate analysis, stem cell source (bone marrow; P=0.0002) was significantly associated with the risk of positive CMV antigenemia, while higher doses of prednisone (>2 mg/kg) represented the major risk factor for bacteremia (P=0.0001).	12931226
Primary central nervous system lymphoma, Varicella Zoster Virus Infection	Stem Cell Exhaustion	[Successful treatment with foscarnet for disseminated varicella-zoster infection after reduced intensity stem cell transplantation in a case of relapsed refractory central nervous system lymphoma].	12931563
Acute GVH disease, Disseminated, herpesvirus 3, human, Communicable Diseases, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Visceral disseminated varicella-zoster virus (VZV) infection occurred with acute graft-versus-host disease in a 33-year-old Japanese male with non-Hodgkin lymphoma who had undergone allogeneic stem cell transplantation from an HLA-identical sibling after reduced intensity conditioning chemotherapy.	12931563
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	[Successful treatment of refractory peripheral T-cell lymphoma by allogeneic peripheral blood stem cell transplantation].	12931564
Chronic graft-versus-host disease	Stem Cell Exhaustion	Evidence for adequate thymic function but impaired naive T-cell survival following allogeneic hematopoietic stem cell transplantation in the absence of chronic graft-versus-host disease.	12933579
Amyotrophic Lateral Sclerosis, nervous system disorder, Parkinson Disease, "Alzheimers Disease	Stem Cell Exhaustion	In 1995, it was suggested that immature stem cells (Berashis Cells) existing in human cord blood might have an ameliorating effect on such neurological diseases as Alzheimer's, amyotrophic lateral sclerosis and Parkinson's disease.	12939116
Diabetes	Stem Cell Exhaustion	NOD/LtJ type I diabetes in mice and the effect of stem cells (Berashis) derived from human umbilical cord blood.	12939117
Hepatitis, Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	We report four cases of small tumours identified in livers with features of chronic hepatitis which may suggest a role for malignant transformation of hepatic stem cells in hepatic malignancies.	12940779
Experimental Organism Malignant Hepatocholangiocellular Carcinoma	Stem Cell Exhaustion	Combined hepatocellular/cholangiocarcinomas have been explained by some investigators as bidirectional differentiation of neoplastic progenitor cell populations.	12940779
Neoplasms, Experimental Organism Malignant Hepatocholangiocellular Carcinoma	Stem Cell Exhaustion	We suggest that these tumours are of hepatic progenitor cell origin, supporting the concepts that human hepatocarcinogenesis can be based on transformation of progenitor cells and that such a process may underlie development of some mixed hepatocellular/cholangiocarcinomas and dysplastic nodules.	12940779
Malignant Neoplasms	Stem Cell Exhaustion	The presence of hepatic progenitor cells has now been confirmed in humans, though whether they can give rise to malignant tumours has not been confirmed.	12940779
Neoplasms	Stem Cell Exhaustion	All tumours contained undifferentiated cells with morphological and immunohistochemical features that would be expected of hepatic progenitor cells.	12940779
Hematologic Neoplasms	Stem Cell Exhaustion	Sixty-six inpatients (34 men, 32 women) undergoing conventional ( n=45) or high-dose chemotherapy with stem cell rescue ( n=21) for the treatment of a hematological malignancy exercised daily on a treadmill.	12942360
leukemia	Stem Cell Exhaustion	To identify proteins specifically expressed in leukemias, here we isolated AC133(+) hematopoietic stem cell-like fractions from the bone marrow of 13 individuals with various leukemic disorders, and compared their protein profiles by two-dimensional electrophoresis.	12944923
Chronic ulcer of lower extremity	Stem Cell Exhaustion	The impaired epithelialization of chronic leg ulcers is not caused by an inadequate epidermal stem cell proliferation, differentiation, or apoptosis.	12947320
Multiple Myeloma	Stem Cell Exhaustion	Autologous peripheral stem cell transplantation for multiple myeloma in a patient with a 10 year-old kidney transplant: case report and clinical issues.	12947876
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Chromosome Aberrations	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders with frequent cytogenetic abnormalities.	12949884
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The CD34+ AC133+ progenitor cell compartment was decreased in CML patients.	12950236
Hemoglobinuria, Hemolysis (biological function), Bone marrow hypocellularity, Thrombosis	Stem Cell Exhaustion	Paroxysmal nocturnal haemoglobinuria is a clonal stem cell disorder manifesting as haemolysis, bone marrow failure and thrombosis.	12950339
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Is chemotherapy scoring useful to predict progenitor cell mobilisation in patients with non-Hodgkin's lymphoma?	12953128
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	We have analysed associations between chemotherapy score and efficiency of progenitor cell mobilisation in 120 consecutive NHL patients mobilised with intermediate-dose cyclophosphamide (4 g/m(2)) plus G-CSF.	12953128
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	Thus, both the original scoring system as well as our more widely applicable scoring system seem to be of limited value in predicting progenitor cell mobilisation in patients with NHL.	12953128
Primary Myelofibrosis	Stem Cell Exhaustion	FLAG chemotherapy followed by allogeneic stem cell transplant using nonmyeloablative conditioning induces regression of myelofibrosis with myeloid metaplasia.	12953130
Hepatosplenomegaly, Primary Myelofibrosis, Anemia, Osteosclerosis, Organomegaly	Stem Cell Exhaustion	A 38-year-old woman with agnogenic myeloid metaplasia complicated by the poor prognostic factors of severe osteosclerosis, prominent hepatosplenomegaly, and profound anemia was treated with FLAG chemotherapy to decrease her organomegaly before undergoing a nonmyeloablative allogeneic stem cell transplant from a matched-sibling donor.	12953130
Multiple Myeloma	Stem Cell Exhaustion	Effect of thalidomide on stem cell collection and engraftment in patients with multiple myeloma.	12953131
Multiple Myeloma	Stem Cell Exhaustion	The purpose of this study was to determine the effect of thalidomide on stem cell collection and engraftment in patients with multiple myeloma.	12953131
Multiple Myeloma	Stem Cell Exhaustion	We performed a retrospective review of 67 patients newly diagnosed with multiple myeloma at Mayo Clinic and treated with a single regimen prior to stem cell transplantation between January of 2000 and September of 2001.	12953131
Rheumatoid Arthritis, Multiple Myeloma	Stem Cell Exhaustion	Early recurrence of rheumatoid arthritis after nonmyeloablative allogeneic blood stem cell transplantation in a patient with multiple myeloma.	12953137
Rheumatoid Arthritis	Stem Cell Exhaustion	Allogeneic blood stem cell transplantation with reduced conditioning has been proposed as a new, potentially curative treatment option for patients with rheumatoid arthritis (RA).	12953137
Rheumatoid Arthritis, Multiple Myeloma	Stem Cell Exhaustion	We report a 60-year-old woman with RA and coexisting multiple myeloma who was treated with high-dose melphalan and autologous blood stem cell transplantation (BSCT) followed by a nonmyeloablative allogeneic BSCT from her healthy dizygotic twin brother.	12953137
Hemoglobinuria	Stem Cell Exhaustion	Allogeneic CD34-enriched peripheral blood stem cell transplantation in a patient with paroxysmal nocturnal haemoglobinuria.	12953138
Hemoglobinuria, Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	Paroxysmal nocturnal haemoglobinuria (PNH) is an acquired clonal disorder of haematopoietic stem cells associated with a somatic mutation in the phosphatidylinositol glycan complementation class A (PIG-A) gene.	12953138
Paroxysmal nocturnal hemoglobinuria, Hemolysis (biological function)	Stem Cell Exhaustion	A 46-year-old male patient with PNH and obvious signs of severe, progressive haemolysis was transplanted in July 2002 with highly purified CD34 T-cell depleted peripheral blood stem cells from his HLA-identical brother.	12953138
Lymphoma, Non-Hodgkin, Lymphoma	Stem Cell Exhaustion	Syngeneic hematopoietic stem-cell transplantation for non-Hodgkin's lymphoma: a comparison with allogeneic and autologous transplantation--The Lymphoma Working Committee of the International Bone Marrow Transplant Registry and the European Group for Blood and Marrow Transplantation.	12963703
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	To compare results of syngeneic, allogeneic, and autologous hematopoietic stem-cell transplantation for non-Hodgkin's lymphoma (NHL).	12963703
Lymphoma, Non-Hodgkin, Familial, Neoplasms	Stem Cell Exhaustion	These analyses failed to find evidence of a graft-versus-lymphoma effect, but do provide indirect evidence to support the hypothesis that tumor contamination may contribute to lymphoma relapse, and that purging may be beneficial for patients undergoing autologous hematopoietic stem-cell transplantation for low-grade NHL.	12963703
Adenocarcinoma of pancreas	Stem Cell Exhaustion	Novel markers of pancreatic adenocarcinoma in fine-needle aspiration: mesothelin and prostate stem cell antigen labeling increases accuracy in cytologically borderline cases.	12966350
Adenocarcinoma of pancreas	Stem Cell Exhaustion	Using serial analysis of gene expression, we have discovered 2 new markers of pancreatic adenocarcinoma, mesothelin and prostate stem cell antigen (PSCA), and confirmed their specificity by immunohistochemical labeling.	12966350
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Moreover, it enabled identification of truly CD34 negative AML, which would be eligible for CD34-based immunological purging of autologous stem cell transplants.	12969806
Multiple Myeloma	Stem Cell Exhaustion	Immunophenotypic analysis of peripheral blood stem cell harvests from patients with multiple myeloma.	12969809
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Impact of frontline fludarabine and cyclophosphamide combined treatment on peripheral blood stem cell mobilization in B-cell chronic lymphocytic leukemia.	12969985
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Ongoing studies in B-cell chronic lymphocytic leukemia are evaluating autologous peripheral blood stem cell (PBSC) transplantation in first remission following fludarabine therapy.	12969985
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Response to imatinib in patients who relapse after allogeneic stem cell transplantation for chronic myeloid leukemia.	12970768
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We studied 128 patients with chronic myeloid leukemia (CML) relapsing after allogeneic stem cell transplantation (SCT).	12970768
Carcinoma, Neuroendocrine, Adenocarcinoma	Stem Cell Exhaustion	It has been suggested that these lesions either originate from multipotent stem cells that also can serve as the origin of nonendocrine adenocarcinomas or arise due to the dedifferentiation of well-differentiated endocrine carcinomas (WDECs).	12973852
Amyotrophic Lateral Sclerosis	Stem Cell Exhaustion	Stem cell therapy in amyotrophic lateral sclerosis: a methodological approach in humans.	13129802
Amyotrophic Lateral Sclerosis, Antilymphocyte Serum	Stem Cell Exhaustion	Recently it has been shown in animal models of amyotrophic lateral sclerosis (ALS) that stem cells significantly slow the progression of the disease and prolong survival.	13129802
Antilymphocyte Serum	Stem Cell Exhaustion	We have evaluated the feasibility and safety of a method of intraspinal cord implantation of autologous mesenchymal stem cells (MSCs) in a few well-monitored patients with ALS.	13129802
Antilymphocyte Serum	Stem Cell Exhaustion	Our results appear to demonstrate that the procedures of ex vivo expansion of autologous mesenchymal stem cells and of transplantation into the spinal cord of humans are safe and well tolerated by ALS patients.	13129802
Hodgkin Disease, Chemosensitivity, Aggressive Non-Hodgkin Lymphoma, Lymphoma, Non-Hodgkin, Familial, HD Term Type	Stem Cell Exhaustion	To determine the outcome of patients with chemosensitive relapsed or primary refractory Hodgkin's disease (HD) or aggressive non-Hodgkin's lymphoma (NHL) whose disease progresses after autologous stem cell transplantation (ASCT), we reviewed the records of 82 patients with HD and 139 patients with NHL transplanted between 1993 and 2000.	13130314
Lymphoma, Follicular	Stem Cell Exhaustion	Ex vivo B cell depletion using the Eligix B Cell SC system and autologous peripheral blood stem cell transplantation in patients with follicular non-Hodgkin's lymphoma.	13130315
Communicable Diseases	Stem Cell Exhaustion	In contrast to allogeneic bone marrow transplantation (allo-BMT), there is a paucity of data on cytomegalovirus (CMV) infection and preemptive therapy (PT) strategies following allogeneic peripheral blood stem cell (allo-PBSC) transplantation.	13130318
Neutropenia, Hematologic Neoplasms, Neoplasms	Stem Cell Exhaustion	Eighty (90.9%) patients had hematological malignancies and eight (9.1%) had solid tumors; 47 patients (53.4%) were neutropenic, 19 (21.6%) were hematopoietic stem cell transplantation (HSCT) recipients, and 27 (30.7%) were in remission.	13680115
Pure Red-Cell Aplasia, Hematologic	Stem Cell Exhaustion	Pure red cell aplasia (PRCA) is a rare hematological syndrome characterized by the lack of red cell progenitors in an otherwise normocellular bone marrow.	14499248
Bone marrow hypocellularity	Stem Cell Exhaustion	In summary, detailed genetic analysis of small numbers of hematopoietic progenitor cells is feasible even in marrow failure states where such cells are present in very small numbers.	14504100
Fanconi Anemia	Stem Cell Exhaustion	Successful hematopoietic stem cell transplantation for Fanconi anemia from an unaffected HLA-genotype-identical sibling selected using preimplantation genetic diagnosis.	14504102
Bone marrow hypocellularity, Fanconi Anemia	Stem Cell Exhaustion	The only proven cure for Fanconi anemia (FA)-associated bone marrow failure is successful allogeneic hematopoietic stem cell transplantation (HSCT).	14504102
Hematologic Neoplasms	Stem Cell Exhaustion	From October 1999 to October 2001, 70 PICCs (Olimpicc, Vygon, Germany, n=40; and LIFECATH-PICC(PUR)5FR Vygon, Germany, n=30) were inserted into 66 patients with haematological malignancies and used for high-dose chemotherapy, total parenteral nutrition and autologous blood stem cell transplantation.	14505156
Hematologic Neoplasms	Stem Cell Exhaustion	Peripherally inserted central venous catheters for autologous blood progenitor cell transplantation in patients with haematological malignancies.	14505156
Malignant lymphoma, stem cell type, Malignant Neoplasms	Stem Cell Exhaustion	The latter group was further divided based on immunohistochemistry into: 1) CD7+ stem cell lymphoma (CD7+SCL) [CD4-, CD7+, CD33+/-, CD56-], 2) blastic natural killer cell lymphoma (B-NKL) [CD4-, CD7+/-, CD33-, CD56+, CD123-], 3) myeloid/NK precursor cell leukemia (M/NKL) [CD4-, CD7+, CD33+, CD56+], and 4) CD4+CD56+ hematodermic malignancy (CD4+CD56+) type [CD4+, CD7+/-, CD33-, CD56+, CD123+].	14508398
Neoplasms	Stem Cell Exhaustion	Among the 21 tumors, the prognosis of the four subtypes did not differ significantly; however, cases receiving aggressive chemotherapy and stem cell transplantation had a more favorable prognosis than those receiving only traditional chemotherapy and radiation therapy (P = 0.0089).	14508398
Autoimmune hemolytic anemia, Gammopathy	Stem Cell Exhaustion	Successful treatment with rituximab for autoimmune hemolytic anemia concomitant with proliferation of Epstein-Barr virus and monoclonal gammopathy in a post-nonmyeloablative stem cell transplant patient.	14513283
Autoimmune hemolytic anemia	Stem Cell Exhaustion	A 30-year-old Japanese woman who underwent nonmyeloablative stem cell transplantation from her HLA-matched sister developed autoimmune hemolytic anemia (AIHA).	14513283
Allogeneic Hematopoietic Stem Cell Transplant Recipient	Stem Cell Exhaustion	Clinical trial of quantitative real-time polymerase chain reaction for detection of cytomegalovirus in peripheral blood of allogeneic hematopoietic stem-cell transplant recipients.	14513415
Cytomegalovirus Infections, Allogeneic Hematopoietic Stem Cell Transplantation	Stem Cell Exhaustion	The preemptive therapy of cytomegalovirus (CMV) reactivation is useful for the prevention of CMV disease in allogeneic hematopoietic stem-cell transplant (HSCT) recipients.	14513415
Malignant neoplasm of gastrointestinal tract	Stem Cell Exhaustion	Ten patients with refractory gastrointestinal cancer received nonmyeloablative allogeneic stem-cell transplantation(NST) from HLA-identical sibling.	14515731
Lymphoma	Stem Cell Exhaustion	Lymphomas at identical sites may have different stem cells.	14517694
Neoplasms	Stem Cell Exhaustion	The chemotherapy might also have affected the chromosomal aberration presumably in endothelial progenitor cells causing the development of a secondary neoplasm.	14518382
Cytomegalovirus Infections, Allogeneic Hematopoietic Stem Cell Transplantation, Pregnancy Complications, Infectious	Stem Cell Exhaustion	CMV disease remains a major infectious complication after allogeneic hematopoietic stem cell transplantation (HSCT).	14520425
Bare Lymphocyte Syndrome, Hemolysis (biological function)	Stem Cell Exhaustion	Severe hemolysis due to passenger lymphocyte syndrome after hematopoietic stem cell transplantation from an HLA-matched related donor.	14521453
Chronic myeloproliferative disorder, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myelogenous leukemia (CML) is a malignant myeloproliferative disease arising from the clonal expansion of a stem cell expressing the bcr/abl oncogene.	14525781
Specialty Type - cancer	Stem Cell Exhaustion	Respiratory syncytial virus (RSV) has been reported to cause severe morbidity and mortality among cancer patients receiving chemotherapy with or without autologous peripheral blood stem cell transplantation (APBSCT).	14525792
Multiple Myeloma	Stem Cell Exhaustion	Current treatment in multiple myeloma consists of three courses of chemotherapy in low doses with subsequent hematopoietic stem cell mobilization to the peripheral blood using high-dose cyclophosphamide, collection and conditioning with high-dose chemotherapy (melphalan) followed by retransplantation of autologous peripheral blood stem cells (PBSCT).	14529938
Multiple Myeloma	Stem Cell Exhaustion	Triple transplantation of autologous peripheral blood stem cells each time following conditioning with 100 mg/m2 of melphalan for multiple myeloma patients in poor performance status.	14529939
Pregnancy Complications, Infectious	Stem Cell Exhaustion	Immune reconstitution and early infectious complications following nonmyeloablative hematopoietic stem cell transplantation.	14530172
Pulmonary Aspergillosis, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	High-risk AML complicated by pulmonary aspergillosis: successful treatment with nonmyeloablative stem cell transplantation and long-term administration of voriconazole.	14530879
Leukemia, Myelocytic, Acute, Mycoses	Stem Cell Exhaustion	The presented case study thus demonstrates that high-risk AML with concomitant invasive fungal infection may be safely and effectively treated by nonmyeloablative stem cell transplantation and long-term administration of voriconazole.	14530879
renal anemia	Stem Cell Exhaustion	We assessed CD34+ circulating stem cells (cSCs) in whole blood using flow cytometry and, in addition, proliferation/differentiation of EPCs in an in-vitro assay during 6 weeks of a standard darbepoetin therapy in eight patients with renal anemia.	14531796
PAFAH1B1 wt Allele, Hematological Disease, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is a clonal disorder of haematopoietic stem cells.	14531911
Extramedullary Plasmacytoma	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation for mediastinal extramedullary plasmocytoma.	14534964
Hematologic Neoplasms, Neoplasms	Stem Cell Exhaustion	Minimal GVHD following in-vitro T cell-depleted allogeneic stem cell transplantation with reduced-intensity conditioning allowing subsequent infusions of donor lymphocytes in patients with hematological malignancies and solid tumors.	14550801
Neoplasms	Stem Cell Exhaustion	Prior chemotherapy and allograft CD34+ dose impact donor engraftment following nonmyeloablative allogeneic stem cell transplantation in patients with solid tumors.	14551148
Malignant Neoplasms	Stem Cell Exhaustion	Irradiated allogeneic blood mononuclear cells administered outside the context of hematopoietic stem-cell transplantation may induce disease responses in patients with relapsed or refractory malignancies.	14551297
Hematopoietic stem cells	Stem Cell Exhaustion	The absolute number of circulating CD34-positive cells is normal or anyhow lower than 15x10(6)/L in patients with uncomplicated PV or ET, whereas it is equal or above this cut-off in those with MMM, likely reflecting abnormal hematopoietic progenitor cell trafficking.	14555308
Primary Myelofibrosis	Stem Cell Exhaustion	Anagrelide failed to exert a stimulating influence on the progression of myelofibrosis or on the amount of CD34+ progenitor cells.	14555309
Multiple Myeloma	Stem Cell Exhaustion	High dose therapy followed by autologous peripheral blood stem cell transplantation as a first line treatment for multiple myeloma: a Korean Multicenter Study.	14555819
Multiple Myeloma	Stem Cell Exhaustion	We conducted a phase II multicenter trial to estimate the response and survival of patients with newly diagnosed multiple myeloma to high dose melphalan therapy followed by autologous peripheral blood stem cell transplantation.	14555819
Multiple Myeloma	Stem Cell Exhaustion	This study verifies the efficacy and feasibility of high dose melphalan therapy with autologous stem cell transplantation in newly diagnosed multiple myeloma.	14555819
Anemia	Stem Cell Exhaustion	Human parvovirus B19 has a strong tissue tropism for erythroid progenitor cells and is a causative agent for anemia.	14556276
Kidney Failure, Acute, Venoocclusive disease	Stem Cell Exhaustion	We report the case of a 41-year-old man who underwent autologous peripheral blood stem cell transplantation and developed and acute renal failure secondary to a fatal veno-occlusive disease of the liver.	14558335
Lymphoma	Stem Cell Exhaustion	Localized radiation increases morbidity and mortality after TBI-containing autologous stem cell transplantation in patients with lymphoma.	14561985
HODGKINS AND NON-HODGKINS LYMPHOMA	Stem Cell Exhaustion	The purpose of this study is to assess the relationship between involved field radiation therapy (IFRT) and treatment-related morbidity and mortality in patients receiving high-dose chemotherapy (HDC), total body irradiation (TBI) and autologous peripheral stem cell transplant (PSCT) for Hodgkin's and non-Hodgkin's lymphoma.	14561985
Lymphoma	Stem Cell Exhaustion	Involved field radiation prior to TBI is associated with higher treatment-related mortality in lymphoma patients undergoing autologous peripheral stem cell transplant, necessitating careful monitoring.	14561985
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The graft-versus-leukemia effect of nonmyeloablative stem cell allografts may not be sufficient to cure chronic myelogenous leukemia.	14561990
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We treated 12 patients with chronic myelogenous leukemia (CML) with a low-intensity preparative regimen followed by allogeneic stem cell transplantation in an attempt to confer a curative graft-versus-leukemia (GVL) effect with minimum morbidity.	14561990
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	These results suggest that cytoreduction is required to optimize the curative effect of allogeneic stem cell transplantation for CML.	14561990
Malignant Neoplasms	Stem Cell Exhaustion	Second malignancy following high-dose therapy and autologous stem cell transplantation: incidence and risk factor analysis.	14561993
Malignant Neoplasms	Stem Cell Exhaustion	To establish incidence and risk factors for development of second malignant neoplasms after high-dose chemo/radiotherapy (HDT) and autologous hematopoietic stem cell transplantation (AHSCT), the case files of 800 consecutive patients who underwent AHSCT at our institution between June 1982 and December 2000 were reviewed.	14561993
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We conclude that telomerase is limiting the growth of the leukemic cell line K562 and primary AML progenitor cells.	14562114
Myeloid Leukemia	Stem Cell Exhaustion	The influence of imatinib mesylate (STI571) used alone or in combination with purine nucleoside analogues on the normal and chronic myelogenous leukaemia progenitor cells in vitro.	14565659
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	In this study we have tried to answer the question if the combination of STI571 with purine nucleoside analogues (PNAs)- cladribine (2-CdA) and fludarabine (F-ara-A) intensifies the antiproliferative effect on granulocyte-macrophage progenitor cells (CFU-GM) from patients with CML as well as from normal persons.	14565659
Toxic effect, Encephalitis Viruses	Stem Cell Exhaustion	West Nile virus encephalitis causing fatal CNS toxicity after hematopoietic stem cell transplantation.	14566328
Deterioration	Stem Cell Exhaustion	We describe here a patient who died of progressive CNS deterioration following allogeneic stem cell transplant with West Nile virus as the sole pathogen on the cerebrospinal fluid and brain tissue analysis.	14566328
Autoimmune state	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation has been used in severe cases of autoimmunity.	14568247
Primary Biliary Cholangitis, Autoimmune Chronic Hepatitis	Stem Cell Exhaustion	Hemopoietic progenitor cells and bone marrow stromal cells in patients with autoimmune hepatitis type 1 and primary biliary cirrhosis.	14568247
Primary Biliary Cholangitis, Autoimmune Chronic Hepatitis	Stem Cell Exhaustion	We investigated whether hemopoietic progenitor cells and/or bone marrow (BM) microenvironment are affected in autoimmune hepatitis type-1 (AIH-1) and primary biliary cirrhosis (PBC).	14568247
Primary Biliary Cholangitis	Stem Cell Exhaustion	Committed progenitor cells in non-adherent cell fraction were increased in AIH-1 (P<0.05) but decreased in PBC compared to controls (P<0.05).	14568247
Hematologic Neoplasms	Stem Cell Exhaustion	Stem cell mobilization by G-CSF in solid and hematological malignancies: single daily dose is better than split dose in obese patients.	14569602
Hepatitis C	Stem Cell Exhaustion	Chronic hepatitis C is often asymptomatic, at least during the first decade following hematopoietic stem cell transplantation.	14576071
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Autologous stem-cell transplantation restores the functional properties of CD14+CD16+ monocytes in patients with myeloma and lymphoma.	14576364
Hematologic Neoplasms, Communicable Diseases	Stem Cell Exhaustion	Myeloablative high-dose chemotherapy (HDT) and subsequent autologous stem-cell transplantation (ASCT) are being used increasingly for therapy of hematological malignancies, but the pronounced immunosuppression renders the patients prone to infection.	14576364
Infection	Stem Cell Exhaustion	Taken together after stem-cell Tx, the function of the CD14++ monocytes is impaired, and the functional properties of CD14+CD16+ monocytes recover, indicating that these cells may be important for defense against infections post-ASCT.	14576364
Carcinoma of lung	Stem Cell Exhaustion	Current paradigms hold that lung carcinomas arise from pleuripotent stem cells capable of differentiation into one or several histological types.	14578194
Rheumatoid Arthritis	Stem Cell Exhaustion	We propose that HLA-DRB1*04 alleles or genes in linkage disequilibrium regulate stem cell replication and contribute to the accumulation of senescent and autoreactive T cells in rheumatoid arthritis.	14578453
Endometrial Carcinoma, Bone marrow stem cell, Intra-abdominal	Stem Cell Exhaustion	Neoadjuvant therapy with high dose chemotherapy via isolated pelvic intra-abdominal perfusion with bone marrow stem cell support for advanced endometrial cancer.	14582223
Multiple Myeloma	Stem Cell Exhaustion	The efficacy of high-dose melphalan with autologous peripheral blood stem cell transplantation in patients with multiple myeloma.	14584095
Multiple Myeloma	Stem Cell Exhaustion	Although high-dose therapy (HDT) with autologous hematopoietic stem cell transplantation (ASCT) is widely accepted as an effective and safe consolidation therapy for multiple myeloma (MM), few reports on its efficacy are available in Korea.	14584095
Harvesting of peripheral blood stem cells	Stem Cell Exhaustion	The treatment consisted of 4 courses of VAD (vincristine, adriamycin, dexamethasone) induction, peripheral blood stem cell collection, and high-dose melphalan with stem cell infusion.	14584095
Liver Dysfunction, Malignant Neoplasms	Stem Cell Exhaustion	More precise studies are needed before clinical application of autologous stem cell infusion for patients with malignant hepatic tumors and impaired liver function.	14584276
Liver carcinoma	Stem Cell Exhaustion	[Harvesting of autologous peripheral blood stem cells following percutaneous isolated hepatic perfusion for patients with advanced hepatocellular carcinoma].	14584276
Liver carcinoma	Stem Cell Exhaustion	In an attempt to increase safety of repeated PIHP, autologous peripheral blood stem cells (PBSC) were harvested after the first PIHP in nine patients with multiple hepatocellular carcinoma with administration of G-CSF.	14584276
Transplant-Related Malignant Neoplasm	Stem Cell Exhaustion	Strategies to reduce transplant-related mortality after allogeneic stem cell transplantation in elderly patients: Comparison of reduced-intensity conditioning and unmanipulated peripheral blood stem cells vs a myeloablative regimen and CD34+ cell selection.	14585367
Multiple Myeloma	Stem Cell Exhaustion	Blood stem cell collections after mobilization with combination chemotherapy containing ifosfamide followed by G-CSF in multiple myeloma.	14586157
Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy with autologous peripheral blood stem cell transplantation is the standard treatment of patients with multiple myeloma today.	14586157
Bronchiolitis Obliterans, Mediastinal Emphysema	Stem Cell Exhaustion	Rhinolalia as a presenting sign of pneumomediastinum complicating post peripheral blood stem cell transplantation bronchiolitis obliterans.	14587046
Histiocytic Disorders, Malignant, Cytopenia	Stem Cell Exhaustion	Severe treatment-induced cytopenia is observed in patients with malignant disorders who receive conventional intensive chemotherapy or autologous stem cell transplantation.	14594509
Growth Hormone-Secreting Pituitary Adenoma	Stem Cell Exhaustion	Taken together, these data suggest that, in addition to the cell mutation mechanism involving an early totipotential progenitor cell, transdifferentiation of existing somatotroph cells also plays a part in the pathogenesis of multihormonal GH-secreting adenomas.	14594554
Rheumatoid Arthritis	Stem Cell Exhaustion	Stem-cells transplantations were used in RA, after which remission and improvements were observed in 80% of patients.	14598506
Nephrotic Syndrome	Stem Cell Exhaustion	Nephrotic syndrome after hematopoietic stem cell transplantation (HSCT) followed by donor lymphocyte infusion (DLI) has never been described.	14604287
Primary Myelofibrosis	Stem Cell Exhaustion	Circulating hematopoietic progenitor cells predict survival in patients with myelofibrosis with myeloid metaplasia.	14607748
Primary Myelofibrosis	Stem Cell Exhaustion	The levels of circulating hematopoietic progenitor cells are often increased in myelofibrosis with myeloid metaplasia (MMM).	14607748
Erythroid Progenitor Cells	Stem Cell Exhaustion	When myeloid and erythroid progenitor cells were calculated separately in the multiple Cox regression analysis, both CFU-GM (hazard ratio 2.8, 95% CI, 1.35 to 5.93) and BFU-E (hazard ratio 2.57, 95% CI, 1.26 to 5.21) numbers above the 75th percentile were independent adverse prognostic factors in our patients.	14607748
Erythroid Progenitor Cells	Stem Cell Exhaustion	High levels of circulating myeloid and erythroid progenitor cells are novel risks factors in patients with MMM.	14607748
Juvenile Myelomonocytic Leukemia	Stem Cell Exhaustion	Isolated CNS relapse following stem cell transplantation for juvenile myelomonocytic leukemia.	14608204
Degenerative polyarthritis	Stem Cell Exhaustion	Identification, quantification and isolation of subpopulations with characteristics of mesenchymal progenitor cells (MPC) from the synovial membrane (SM) from patients with osteoarthritis (OA).	14609532
Acute myocardial infarction	Stem Cell Exhaustion	Autologous intramyocardial injection of cultured skeletal muscle-derived stem cells in patients with non-acute myocardial infarction.	14613737
Intestinal metaplasia, Helicobacter-associated gastritis	Stem Cell Exhaustion	The topographical study of p27(Kip1) revealed a p27(kip1)-positive epithelial cell population that resided deep in the proliferating zone; these cells were considered to be stem cells and were found significantly increased in areas with intestinal metaplasia (P <.05); in H. pylori gastritis, there was also an increase that did not reach statistical significance.	14614046
Intestinal metaplasia, Infection caused by Helicobacter pylori, Carcinogenesis	Stem Cell Exhaustion	The increased cellular turnover, together with the increased number of putative p27(Kip1)-positive stem cells in the context of intestinal metaplasia, provides further evidence for the role of H. pylori infection in gastric carcinogenesis.	14614046
In-Stent Restenosis Indicator	Stem Cell Exhaustion	Number and adhesive properties of circulating endothelial progenitor cells in patients with in-stent restenosis.	14615392
Primary central nervous system lymphoma	Stem Cell Exhaustion	Intensive methotrexate and cytarabine followed by high-dose chemotherapy with autologous stem-cell rescue in patients with newly diagnosed primary CNS lymphoma: an intent-to-treat analysis.	14615443
Primary central nervous system lymphoma	Stem Cell Exhaustion	To assess the safety and efficacy of intensive methotrexate-based chemotherapy followed by high-dose chemotherapy (HDT) with autologous stem-cell rescue in patients with newly diagnosed primary CNS lymphoma (PCNSL).	14615443
Gastrointestinal complication	Stem Cell Exhaustion	Early and late gastrointestinal complications after myeloablative and nonmyeloablative allogeneic stem cell transplantation.	14615909
Gastrointestinal symptom	Stem Cell Exhaustion	Upper and lower gastrointestinal symptoms are major and serious complications after stem cell transplantation.	14615909
gastrointestinal, Hematological Disease	Stem Cell Exhaustion	Between January 1996 and September 2001, we analyzed 42 consecutive patients who had been admitted at our institution for gastrointestinal complaints after allogeneic stem cell transplantation for hematologic diseases.	14615909
Infectious colitis, Gastrointestinal complication	Stem Cell Exhaustion	Gastrointestinal GVHD and infectious colitis accounted for the majority of gastrointestinal complications after allogeneic stem cell transplantation in our patient population.	14615909
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	This study evaluates the immunological effects in 21 patients with multiple myeloma (MM) following allogeneic stem cell transplantation with a non-myeloablative conditioning regimen.	14616968
Cytomegalovirus Infections	Stem Cell Exhaustion	Impact of unrelated donor status on the incidence and outcome of cytomegalovirus infections after non-myeloablative allogeneic stem cell transplantation.	14616970
Infection	Stem Cell Exhaustion	Little is known about the impact of cytomegalovirus (CMV) infections that occur after human leucocyte antigen (HLA)-matched unrelated donor (MUD) non-myleoablative haematopoietic stem cell transplantation (HCT).	14616970
PUM3 gene, Acute GVH disease	Stem Cell Exhaustion	Disparity for a newly identified minor histocompatibility antigen, HA-8, correlates with acute graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling.	14616971
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Mobilization of Ph chromosome-negative peripheral blood stem cells in chronic myeloid leukaemia patients with imatinib mesylate-induced complete cytogenetic remission.	14617010
Pregnancy Complications, Infectious	Stem Cell Exhaustion	Infectious complications following nonmyeloablative allogeneic hematopoietic stem cell transplantation.	14617301
Hematologic Neoplasms, Toxic effect, Neoplasms	Stem Cell Exhaustion	Nonmyeloablative hematopoietic stem cell transplantation (NST) has been explored in hematological malignancies and solid tumors in an attempt to minimize treatment-related toxicity.	14617301
Transfusion-Related Acute Lung Injury	Stem Cell Exhaustion	TRALI should be recognized as a rare but serious complication in allogeneic hematopoietic stem cell transplantation.	14617314
Hematological Disease	Stem Cell Exhaustion	Bone marrow/stem cell transplantation is becoming an increasingly common treatment for a variety of hematologic disorders.	14618861
Desmoplastic Small Round Cell Tumor	Stem Cell Exhaustion	Coexpression of epithelial, mesenchymal, and neural antigens in the same cell provides evidence that DSRCT may arise from a primitive pluripotent stem cell with divergent differentiation.	14620681
Juvenile Myelomonocytic Leukemia, BCR gene	Stem Cell Exhaustion	Our results indicate that the transformation from B-cell ALL to JMML in this case occurred most probably in the granulocyte-erythroid-macrophage-megakaryocyte progenitor cells without involving the lymphoid cell line.	14623459
Toxic effect	Stem Cell Exhaustion	Stem cell transplantation still has significant toxicity and cannot be recommended for the elderly.	14624342
Meibomian gland dysfunction	Stem Cell Exhaustion	Deficient dietary intake of vitamin E in patients with taste and smell dysfunctions: is vitamin E a cofactor in taste bud and olfactory epithelium apoptosis and in stem cell maturation and development?	14624956
Peripheral Stem Cell Transplantation, Respiratory Tract Infections	Stem Cell Exhaustion	Active surveillance for respiratory virus infections in adults who have undergone bone marrow and peripheral blood stem cell transplantation.	14625580
Residual volume	Stem Cell Exhaustion	To investigate the viral etiology, incidence, clinical presentation, and outcome of RV infections in an outpatient cohort of adult bone marrow or peripheral blood stem cell transplant (SCT) recipients, we monitored 62 outpatient volunteers from January 1 to April 30, 2001.	14625580
Hemorrhagic cystitis	Stem Cell Exhaustion	Late hemorrhagic cystitis after reduced-intensity hematopoietic stem cell transplantation (RIST).	14625581
CLTC gene, Hemorrhagic cystitis	Stem Cell Exhaustion	We reviewed medical records of 256 patients to investigate the frequency and characteristics of hemorrhagic cystitis (HC) associated with reduced-intensity stem cell transplantation (RIST) as opposed to conventional stem cell transplantation (CST); 137 patients underwent CST and 119 RIST.	14625581
Fibrosis Assessment, Primary Myelofibrosis	Stem Cell Exhaustion	Reversal of marrow fibrosis in agnogenic myeloid metaplasia by allogeneic peripheral blood stem cell transplantation.	14629130
bone marrow fibrosis, Primary Myelofibrosis, Extramedullary Hematopoiesis Function, Splenomegaly	Stem Cell Exhaustion	Agnogenic myeloid metaplasia (AMM) is a clonal hematopoietic stem cell disorder characterized by bone marrow fibrosis, extramedullary hemopoiesis, splenomegaly and a leukoerythroblastic blood picture.	14629130
Nasal Type Extranodal NK/T-Cell Lymphoma, Neoplasms	Stem Cell Exhaustion	Status of tumor cell differentiation in nasal NK/T cell lymphoma may have passed the stage of progenitor cell differentiation but not yet to the stage of mature T or NK cells.	14633456
Hypopigmentation disorder	Stem Cell Exhaustion	Several lines of evidence have previously reported that KIT and its ligand stem cell factor (SCF) have a regulatory role in melanocyte development and survival, suggesting a rational mechanism of action for imatinib mesylate in the pathogenesis of hypopigmentation.	14635084
Pure Red-Cell Aplasia	Stem Cell Exhaustion	Successful treatment of acquired pure red cell aplasia (PRCA) by allogeneic peripheral blood stem cell transplantation.	14635209
Pure Red-Cell Aplasia	Stem Cell Exhaustion	A 37-year-old male was treated successfully by peripheral blood stem cell transplantation (PBSCT) from his HLA-identical sister for refractory acquired pure red cell aplasia (PRCA).	14635209
Plasmacytoma - category, Post-transplant lymphoproliferative disorder, Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation	Stem Cell Exhaustion	Treatment of postrenal transplantation lymphoproliferative disease manifesting as plasmacytoma with nonmyeloablative hematopoietic stem cell transplantation from the same kidney donor.	14635212
Blast Phase	Stem Cell Exhaustion	Acceleration and blastic crisis were characterized by the appearance of immature and CD34+ progenitor cells.	14636273
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Allogeneic stem cell transplantation is a curative therapy for MDS.	14639946
Cessation of life	Stem Cell Exhaustion	It is necessary to reduce transplantation related death and to perform stem cell transplantation as soon as possible for patients with Int-2 or High risk of IPSS.	14639946
Hematologic Neoplasms	Stem Cell Exhaustion	Nonmyeloablative stem cell transplantation with fludarabine and cyclophosphamide for patients with hematologic malignancies.	14641143
Hematologic Neoplasms	Stem Cell Exhaustion	We conducted a multi-center phase I/II trial of nonmyeloablative stem cell transplantation for patients with hematologic malignancies.	14641143
Hematologic Neoplasms	Stem Cell Exhaustion	Our study confirms that nonmyeloablative stem cell transplantation with cyclophosphamide and fludarabine conditioning is a safe and promising treatment for elderly patients with hematologic malignancies.	14641143
Amyloidosis	Stem Cell Exhaustion	Autologous stem cell transplantation in primary systemic amyloidosis: the impact of selection criteria on outcome.	14647248
Amyloidosis	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) for primary systemic amyloidosis (AL) produces high hematologic and organ responses.	14647248
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	More efficient mobilisation of peripheral blood stem cells with HiDAC+AMSA+G-CSF than with mini-ICE+G-CSF in patients with AML.	14647265
Lymphoma, Non-Hodgkin, Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	In vitro assessment of bone marrow endothelial colonies (CFU-En) in non-Hodgkin's lymphoma patients undergoing peripheral blood stem cell transplantation.	14647271
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	The distribution and functional characteristics of in vitro bone marrow (BM) endothelial colonies (CFU-En) were studied in 70 non-Hodgkin's lymphoma (NHL) patients in different phases of the disease to explore the association between CFU-En growth and angiogenesis, and between the number of CFU-En and the presence of hematopoietic and mesenchymal progenitor cells.	14647271
Specialty Type - cancer	Stem Cell Exhaustion	In contrast to cancer cells and embryonic stem cells, the lifespan of primary human cells is finite.	14647293
MS gene	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation in a patient affected by large granular lymphocyte leukemia and multiple sclerosis.	14648027
Multiple Sclerosis, Chronic Progressive, leukemia	Stem Cell Exhaustion	We describe a 57-year-old man, affected by large granular lymphocyte (LGL) leukemia and concomitant primary progressive multiple sclerosis (MS), treated with allogeneic hematopoietic stem cell transplantation (HSCT) from an HLA-identical sibling.	14648027
Childhood Breast Carcinoma	Stem Cell Exhaustion	From 1996 to 2000, high-dose chemotherapy with haematopoietic stem-cell support was used as an adjuvant treatment strategy for management of primary high-risk breast cancer patients with more than five positive nodes.	14651213
Toxic effect	Stem Cell Exhaustion	This study focuses on quality control including evaluation of toxicity, supportive therapy and assessment of the stem-cell products.	14651213
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Survival after second hematopoietic stem cell transplantation for recurrent pediatric acute myeloid leukemia.	14652854
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Recurrent acute myeloid leukemia (AML) after hematopoietic stem cell transplantation (HSCT) predicts a dismal prognosis.	14652854
Anemia, Peripheral Stem Cell Transplantation, Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	In this report, we show in a first cohort of 45 lymphoma or myeloma patients undergoing peripheral blood stem cell transplant (control group) that endogenous erythropoietin levels are high for the degree of anemia during the first 3 weeks after transplant but become adequate or slightly decreased thereafter.	14654537
Anemia	Stem Cell Exhaustion	Anemia after autologous peripheral blood stem cell transplant is exquisitely sensitive to rHuEpo when therapy is started soon after engraftment.	14654537
Tissue injury, Inflammation	Stem Cell Exhaustion	Polymorphisms in cytokine genes can influence immune responses, inflammation, and tissue injury and may affect the outcome of hematopoietic stem-cell transplantation.	14657427
Primary Lesion, In-Stent Restenosis Indicator	Stem Cell Exhaustion	As a key finding, expression of endothelial progenitor cells (CD34: 7.1+/-2.5% positive/total cells vs. 0.6+/-0.7%, P<0.001; AC133: 7.0+/-3.4% vs. 1.0+/-0.7%, P<0.001), dendritic cells (S100: 9.8+/-5.6% vs. 1.4+/-1.1%, P<0.001) and neural-crest-derived cells (GFAP: 7.9+/-2.4% vs. 3.1+/-1.0%; NSE: 4.4+/-2.6% vs. 1.3+/-1.6%; NGFR: 4.2+/-2.5% vs. 1.1+/-0.7%; each P<0.001) was significantly increased in in-stent restenosis compared to primary lesions.	14659814
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The important role of T cells and T-cell cytokines in the long-term control of CML is well established, for example in allogeneic stem-cell graft recipients.	14660054
Specialty Type - cancer	Stem Cell Exhaustion	High-dose carboplatin, cyclophosphamide, etoposide with hematological growth factors, without stem cell support in patients with advanced cancer.	14666615
Toxic effect, Neoplasms	Stem Cell Exhaustion	Peripheral blood progenitor cell (PBPC) transplantation, introduced into clinical practice to decrease the hematological toxicity of high-dose chemotherapy (HDCT), is both a costly procedure and a potential source of tumor cell reinfusion.	14666615
Fanconi Anemia	Stem Cell Exhaustion	Preparative therapies used for those with Fanconi's anemia undergoing stem cell transplants and subsequent engraftment rates.	14668035
MYELODYSPLASTIC SYNDROME, Fanconi Anemia	Stem Cell Exhaustion	Fanconi anemia patients are often treated with stem cell transplants to prevent myelodysplastic changes or leukemic progression.	14668035
Mantle cell lymphoma, Neoplasms	Stem Cell Exhaustion	Long-term follow-up of autologous stem cell transplantation in patients with diffuse mantle cell lymphoma in first disease remission: the prognostic value of beta2-microglobulin and the tumor score.	14669282
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	The current study was conducted to analyze the long-term results of autologous stem cell transplantation (ASCT) in patients with diffuse mantle cell lymphoma (MCL) in first disease remission.	14669282
Hematologic Neoplasms	Stem Cell Exhaustion	[Allogeneic stem cell transplantation following non-myeloablative conditioning: favorable results in 21 high risk patients with hematological malignancies treated in the Utrecht University Medical Center, the Netherlands].	14669540
Hematologic Neoplasms	Stem Cell Exhaustion	To describe the results of allogeneic stem cell transplantation after non-myeloblative conditioning in high-risk patients with a haematological malignancy.	14669540
Hematologic Neoplasms	Stem Cell Exhaustion	In the Utrecht University Medical Centre 21 patients in an advanced stage of various haematological malignancies were treated with allogeneic stem cell transplantation following non-myeloablative conditioning.	14669540
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	The prognostic impact of autologous stem cell transplantation in patients with chronic lymphocytic leukemia: a risk-matched analysis based on the VH gene mutational status.	14670929
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	To assess the therapeutic value of sequential high-dose therapy (SHDT) including autologous stem cell transplantation in chronic lymphocytic leukemia (CLL) we performed a risk-matched comparison between 66 patients who had undergone a uniform SHDT regimen and a database of 291 patients treated conventionally.	14670929
Aortic Aneurysm	Stem Cell Exhaustion	These data indicate that, in newly diagnosed and refractory patients with AAA, CD4+ cells are polarized towards a type-1 response that in turn leads to activation of cytotoxic CD8+ cells and finally to haemopoietic stem cell destruction.	14675414
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation in adult patients with peripheral T-cell lymphoma: a nation-wide survey.	14676776
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Limited experience is available on the feasibility and efficacy of high-dose therapy (HDT) supported by autologous stem cell transplantation (ASCT) in patients with peripheral T-cell lymphoma (PTCL).	14676776
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Infused peripheral blood autograft absolute lymphocyte count correlates with day 15 absolute lymphocyte count and clinical outcome after autologous peripheral hematopoietic stem cell transplantation in non-Hodgkin's lymphoma.	14676784
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Absolute lymphocyte count at day 15 (ALC-15) after autologous peripheral blood hematopoietic stem cell transplantation (APHSCT) is an independent prognostic factor for survival in non-Hodgkin's lymphoma (NHL).	14676784
PAFAH1B1 wt Allele	Stem Cell Exhaustion	We treated 18 MDS patients ineligible for standard allogeneic transplantation with a preparative regimen of photopheresis day -7 and -6, pentostatin 4 mg/m(2) by continuous infusion day -5 and -4, and total body irradiation 600 cGy in 3 fractions day -3 and -2, followed by allogeneic stem cell infusion from 6/6 or 5/6 HLA-matched related donors or 6/6 HLA-matched unrelated donors.	14677114
Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy with autologous stem cell transplantation after initial cytoreductive chemotherapy with the combination vincristine, doxorubicin and dexamethasone (VAD) is considered an effective therapy for many patients with newly diagnosed, symptomatic multiple myeloma.	14679133
Depression, CTCAE	Stem Cell Exhaustion	Age-dependent depression in circulating endothelial progenitor cells in patients undergoing coronary artery bypass grafting.	14680729
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	[Autologous hematopoietic stem cell transplantation for the treatment of aggressive non-Hodgkin's lymphoma.	14682225
Aggressive Non-Hodgkin Lymphoma, Lymphoma, Non-Hodgkin, Familial, Lymphoma	Stem Cell Exhaustion	We analysed the outcome of 200 patients, aged 38 (13-72) years, with aggressive non-Hodgkin's lymphoma (NHL) treated with high-dose chemotherapy followed by autologous haematopoietic stem cell transplantation (autoHSCT) in ten oncohaematological centres belonging to Polish Lymphoma Research Group (PLRG).	14682225
Anaplastic Oligodendroglioma	Stem Cell Exhaustion	High-dose chemotherapy with stem cell rescue as initial therapy for anaplastic oligodendroglioma.	14686732
Anaplastic Oligodendroglioma	Stem Cell Exhaustion	To improve disease control and postpone cranial radiotherapy, we designed a phase II study of intensive procarbazine, lomunstine and vincristine followed by high-dose thiotepa with autologous stem cell rescue for patients with newly diagnosed anaplastic or aggressive oligodendroglioma.	14686732
Anaplastic Oligodendroglioma, Neoplasms	Stem Cell Exhaustion	High-dose chemotherapy with stem cell rescue as initial treatment for anaplastic oligodendroglioma is feasible and associated with prolonged tumor control in some patients.	14686732
Lymphoma, Rhabdomyolysis	Stem Cell Exhaustion	Influenza-induced rhabdomyolysis after autologous peripheral blood stem cell transplantation for malignant lymphoma.	14686755
Congestive heart failure, Lymphoma	Stem Cell Exhaustion	We report influenza-induced rhabodmyolysis and congestive heart failure after high-dose therapy and hematopoietic stem cell transplantation for malignant lymphoma.	14686755
Acute congestive heart failure, Lymphoma	Stem Cell Exhaustion	Four months after autologous peripheral blood stem cell transplantation for the treatment of malignant lymphoma, a 65-year-old Japanese man developed acute congestive heart failure requiring artificial ventilation and rahbdomyolysis.	14686755
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Filgrastim-induced stem cell mobilization in chronic myeloid leukaemia patients during imatinib therapy: safety, feasibility and evidence for an efficient in vivo purging.	14687030
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	To assess the possibility of stem cell mobilization (SCM) during imatinib therapy we performed granulocyte colony-stimulating factor (filgrastim)-induced SCM and subsequent aphaeresis in 15 chronic phase and three accelerated phase CML patients.	14687030
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	High dose chemotherapy and autologous stem cell transplantation in patients with peripheral T-cell lymphoma not achieving complete response after induction chemotherapy.	14687990
Hematologic Neoplasms	Stem Cell Exhaustion	One-hundred and nineteen peripheral blood progenitor cells (PBPC) collections from 104 patients with hematologic malignancies were cryopreserved in bags, with an URF procedure, in a cryoprotectant solution consisting of PBS, HSA and 10% DMSO and stored in liquid nitrogen.	14687993
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	We have previously shown that CD8 depletion or CD34 selection of peripheral blood stem cells (PBSC) reduced the incidence of acute graft-versus-host disease (GvHD) after nonmyeloablative stem-cell transplantation (NMSCT).	14688520
Malignant neoplasm of stomach, Thrombosis	Stem Cell Exhaustion	Fatal deep vein thrombosis after allogeneic reduced intensity hematopoietic stem cell transplantation for the treatment of metastatic gastric cancer.	14689233
Malignant neoplasm of stomach	Stem Cell Exhaustion	A 61-year-old man received reduced intensity stem cell transplantation (RIST) for the treatment of metastatic gastric cancer.	14689233
Anemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	[Successful T-cell-replete peripheral blood stem cell transplantation from an HLA 2 loci mismatched mother to her son with refractory anemia in myelodysplastic syndrome].	14689871
Anemia, Peripheral Blood Stem Cells, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	A 15-year-old male with refractory anemia in myelodysplastic syndrome underwent peripheral blood stem cell transplantation from his two-loci-mismatched haploidentical mother.	14689871
Graft-vs-Host Disease	Stem Cell Exhaustion	This successful experience suggests that maternal hematopoietic stem cell transplant for children, in specific immune tolerance based on the presence of microchimerism and compatibility of minor histocompatibility antigens between mother and child, may have given rise to the favorable preventing effect against severe GVHD.	14689871
Graft-vs-Host Disease	Stem Cell Exhaustion	Non-T-cell-depleted peripheral blood stem cells were infused with graft-versus-host disease (GVHD) prophylaxis consisting of tacrolimus and short-course methotrexate.	14689871
PAFAH1B1 wt Allele, leukemia	Stem Cell Exhaustion	[Sustained remission of MDS overt leukemia associated with abrupt discontinuation of immunosuppression following relapse after the second course of allogeneic hematopoietic stem cell transplantation].	14689872
Atherosclerosis	Stem Cell Exhaustion	Bone marrow-derived endothelial progenitor cells (EPCs) are thought to exert beneficial effects on atherosclerosis, angiogenesis, and vascular repair.	14691039
Liver Cirrhosis	Stem Cell Exhaustion	The expressions of c-kit and c-Met, as a hematopoietic and hepatic stem cell marker, were seen frequently in ICC with cirrhosis (80% and 80%, respectively) and ICC elements of the combined one (63% and 50%, respectively).	14691921
Specialty Type - cancer, Lymphoma, leukemia	Stem Cell Exhaustion	The study population included two different cohorts: A) patients with advanced metastatic cancer included in a prospective randomized study of palliative radiotherapy (n = 238); B) patients with leukaemia and malignant lymphoma curatively treated with stem-cell transplantation and high-dose chemotherapy (n = 128).	14694917
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Specific immunotherapies for patients with acute myeloid leukemia (AML) using leukemia-associated antigens (LAA) as target structures might be a therapeutic option to enhance the graft-vs.-leukemia effect observed after allogeneic stem cell transplantation or to prolong a complete remission (CR) achieved by chemotherapy.	14696097
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Both patients had relapsed MM following chemotherapy and had autologous stem-cell transplant, whereas their CLL has been stable and not requiring treatment.	14697640
malignant disease, Cardiac Arrest, Lymphoma	Stem Cell Exhaustion	Our patient illustrates that SCA in itself does not preclude autologous stem cell transplantation for lymphoma in selected patients, and this report should encourage others to consider autologous BMT in adults with SCA where it represents a lifesaving therapy for malignant diseases.	14697986
Corneal epithelial defect	Stem Cell Exhaustion	After differentiation from a persistent corneal epithelial defect and limbal stem cell deficiency by dye staining and impression cytology, the patient in this case of CCIN was successfully treated with topical MMC and interferon alfa-2b in cycles.	14701965
Juvenile rheumatoid arthritis	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation for 3 patients with severe juvenile rheumatoid arthritis.	14704040
Juvenile rheumatoid arthritis	Stem Cell Exhaustion	We performed autologous CD34+ stem cell transplantation in 3 patients with juvenile rheumatoid arthritis (JRA) refractory to conventional treatment.	14704040
Multiple Myeloma	Stem Cell Exhaustion	High-dose therapy/autologous stem cell transplantation in patients with chemosensitive multiple myeloma: predictors of complete remission.	14704657
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	High-dose therapy (HDT) followed by autologous stem cell support is widely used as intensification treatment in patients with multiple myeloma (MM) responsive to the initial chemotherapy.	14704657
Graft-vs-Host Disease	Stem Cell Exhaustion	Combined standard graft-versus-host disease (GvHD) prophylaxis with mycophenolate mofetil (MMF) in allogeneic peripheral blood stem cell transplantation from unrelated donors.	14704658
Hematologic Neoplasms	Stem Cell Exhaustion	In all, 30 patients aged 20-59 years with advanced haematological malignancies received an unmanipulated blood-stem-cell graft (median of 8.5 x 10(6) CD34(+) and 349 x 10(6) CD3(+) cells per bodyweight) from matched unrelated (n=26), or mismatched donors (n=4).	14704658
Leukemia, Large Granular Lymphocytic	Stem Cell Exhaustion	T-cell large granular lymphocytic leukemia occurring after autologous peripheral blood stem cell transplantation.	14704662
Angioimmunoblastic Lymphadenopathy	Stem Cell Exhaustion	A 61-year-old man with angioimmunoblastic lymphoma in first complete remission underwent autologous peripheral blood stem cell transplantation.	14704662
T-Cell Large Granular Lymphocyte Leukemia, Lymphoproliferative Disorders	Stem Cell Exhaustion	Although post transplantation T-cell lymphoproliferative disorders have mostly occurred in allogeneic transplantation recipients and presented as aggressive lymphomas/leukemias, we suggest that chronic indolent T-cell large granular lymphocytic leukemia can occur after autologous stem cell transplantation.	14704662
Infantile malignant osteopetrosis	Stem Cell Exhaustion	These bone-specific markers may be useful for the early assessment of malignant infantile osteopetrosis patients with stem cell transplantation.	14707702
Anaplastic large B-cell lymphoma	Stem Cell Exhaustion	Sixteen routinely processed IFP specimens (14 gastric, 1 ileal, and 1 rectal) were immunohistochemically stained for antibodies to CD34, HMB-45, desmin, smooth muscle actin, calponin, h-caldesmon, anaplastic lymphoma kinase, S-100 protein, epithelial membrane antigen, c-kit (CD117), stem cell factor (SCF/N19 or kit ligand), p53, bcl-2, cyclin D1, and human herpesvirus-8 (HHV8).	14707872
Hair follicle structure	Stem Cell Exhaustion	Keratin 15 promoter targets putative epithelial stem cells in the hair follicle bulge.	14708593
Specialty Type - cancer	Stem Cell Exhaustion	We report for the first time that the decrease in myoblast stem cell numbers seen with normal aging is lost in cancer patients.	14710345
Malignant Neoplasms	Stem Cell Exhaustion	Furthermore we provide initial evidence to suggest that there is an apparent altered regulation of local IGFBP-3 production during malignancy which may enable satellite cell proliferation, stem cell infiltration or both.	14710345
Communicable Diseases	Stem Cell Exhaustion	Autologous peripheral blood stem cell transplantation (PBSCT) was effective; however, she died of severe infection after the second PBSCT.	14714955
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	Successful treatment of limited disease-small cell lung cancer with multimodality treatment consisting of concurrent chemoradiotherapy, high-dose chemotherapy with autologous peripheral blood stem cell transplantation and surgical resection.	14714964
Venoocclusive disease, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	He did not have a history of hematopoietic stem cell transplantation, which is usually the case in AML patients who develop veno-occlusive disease of the liver after treatment with Mylotarg.	14716035
Acute Promyelocytic Leukemia	Stem Cell Exhaustion	Early relapse after non myeloablative allogeneic stem cell transplantation in a patient with acute promyelocytic leukemia in complete molecular remission.	14716110
Acute Promyelocytic Leukemia, ATRICHIA WITH PAPULAR LESIONS	Stem Cell Exhaustion	We described a 41-year-old patient with acute promyelocytic leukemia (APL) who experienced two successive relapses: one after all-trans retinoic acid (ATRA) treatment and chemotherapy, and another after ATRA treatment and chemotherapy, followed by autologous peripheral blood stem cell transplantation.	14716110
Neurologic Deficits, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 55-year-old man with acute myeloid leukemia in second relapse presented 4 months after haploidentical CD34+-selected hematopoietic stem cell transplantation (HSCT) with symmetric, progressive neurological deficits of the lower extremities.	14716290
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myelogenous leukemia in a donor after granulocyte colony-stimulating factor-primed peripheral blood stem cell harvest.	14716337
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This article describes the first case of acute myeloid leukemia (AML) in a healthy donor at 14 months after granulocyte colony-stimulating factor (G-CSF)-primed peripheral blood stem cell (PBSC) harvest.	14716337
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Autologous del(20q)-positive erythroid progenitor cells, re-emerging after DLI treatment of an MDS patient relapsing after allo-SCT, can provide a normal peripheral red blood cell count.	14716343
Bronchiolitis Obliterans, Graft-vs-Host Disease, bottle - unit dose, Chronic graft-versus-host disease	Stem Cell Exhaustion	Bronchiolitis obliterans (BO) is a manifestation of chronic graft-versus-host disease (GVHD) after allogeneic haemopoietic stem cell transplantation.	14716352
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Nonablative allogeneic stem cell transplantation for chronic lymphocytic leukemia: impact of rituximab on immunomodulation and survival.	14725898
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	To investigate the graft-vs-leukemia effect of allogeneic stem cell transplantation after a nonablative conditioning regimen as treatment for patients with chronic lymphocytic leukemia.	14725898
Specialty Type - cancer, Carcinogenesis	Stem Cell Exhaustion	Events during neosis, and its relevance to origin of established cell lines, multistep carcinogenesis, cancer stem cells, and therapeutic advantages of anti-neotic agents (neosicides) are discussed.	14726689
Unknown (origin) (qualifier value), Malignant Neoplasms, Purpura, Thrombotic Thrombocytopenic	Stem Cell Exhaustion	The former patients were associated with "idiopathic" TTP, drugs, and pregnancy, and the latter patients with malignancy and stem cell transplantation.	14727261
Hematological Disease, Thrombotic Microangiopathies, Hemolytic-Uremic Syndrome, Unknown (origin) (qualifier value), Thrombomodulin Alfa, Treatment related secondary malignancy, Diarrhea	Stem Cell Exhaustion	Patients were assigned to 10 predefined clinical categories according to information provided by the referring clinician: thrombotic microangiopathy (TMA) not further specified; neoplasia- or chemotherapy-associated TMA; TMA following hematopoietic stem cell transplantation; TMA with additional/alternative disorder; idiopathic TTP; hemolytic-uremic syndrome (HUS) not specified; HUS with diarrhea prodrome (D+HUS); atypical HUS; other hematological disorder; and no clinical information available.	14727262
Thrombomodulin Alfa, Hemolytic-Uremic Syndrome	Stem Cell Exhaustion	Severe ADAMTS-13 deficiency was found in 60% of patients diagnosed with acute idiopathic TTP, but in none of 130 patients diagnosed with HUS or in any of the 14 patients with hematopoietic stem cell transplantation-associated TMA.	14727262
Leukemia, T-Cell	Stem Cell Exhaustion	Graft-versus-Tax response in adult T-cell leukemia patients after hematopoietic stem cell transplantation.	14729650
TRPV6 wt Allele	Stem Cell Exhaustion	Recent clinical trials have indicated, however, that allogeneic but not autologous hematopoietic stem cell transplantation (HSCT) for ATL can yield better clinical outcomes.	14729650
Carcinoma	Stem Cell Exhaustion	LOH analysis was also performed in tissues of cholangiolocellular carcinoma, which is thought to originate from a common stem cell progenitor of hepatocytes and bile duct epithelial cells.	14731065
Amyloidosis	Stem Cell Exhaustion	High-dose melphalan and autologous stem-cell transplantation in patients with AL amyloidosis: an 8-year study.	14734330
Amyloidosis	Stem Cell Exhaustion	Among 701 patients with AL amyloidosis, 394 (56%) were eligible for high-dose melphalan and stem-cell transplantation; 82 did not proceed with treatment because of patient choice or disease progression.	14734330
Cardiomyopathies	Stem Cell Exhaustion	Mortality rate within 100 days of treatment with high-dose melphalan and stem-cell transplantation was 13%; patients with cardiomyopathy had the highest mortality rates.	14734330
Amyloidosis	Stem Cell Exhaustion	Treatment of selected patients with AL amyloidosis by using high-dose melphalan and stem-cell transplantation resulted in hematologic remission, improved 5-year survival, and reversal of amyloid-related disease in a substantial proportion.	14734330
Cytotoxic T-Lymphocytes, leukemia, Cytopenia, Lymphoproliferative Disorders	Stem Cell Exhaustion	Large granular lymphocytic (LGL) leukemia is a clonal lymphoproliferative disorder of CTL associated with cytopenias resulting from an immune and cytokine attack on hemopoietic progenitor cells.	14734782
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	PET scan evaluation of thymic mass after autologous peripheral blood stem-cell transplantation in an adult with non-Hodgkin's lymphoma.	14738158
Ki-1+ Anaplastic Large Cell Lymphoma	Stem Cell Exhaustion	We report the case of a 31-year-old man with anaplastic large-cell lymphoma successfully treated with chemotherapy who showed mediastinal widening 5 months after autologous stem-cell transplantation.	14738158
Pulmonary Thromboembolisms	Stem Cell Exhaustion	Fatal pulmonary thromboembolism after a second course of high-dose chemotherapy with autologous peripheral blood stem cell transplantation.	14738303
Liver and Intrahepatic Biliary Tract Carcinoma	Stem Cell Exhaustion	Fifty-four cases of primary liver carcinomas were selected and an immunohistochemical analysis was performed using hepatocytic markers (alpha-fetoprotein, hepatocyte), cholangiocytic markers (carcinoembryonic antigen, cytokeratin 19) and progenitor cell marker (c-kit).	14739102
Liver carcinoma, Hollings Cancer Center, Non-Metastatic Carcinoma, Cholangiocarcinoma	Stem Cell Exhaustion	Recent evidence of hepatic progenitor cells with the bipotential to differentiate into hepatocytes and cholangiocytes gives rise to the suggestion that primary hepatic carcinomas with features intermediate between hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) may originate from hepatic progenitor cells.	14739102
Liver and Intrahepatic Biliary Tract Carcinoma, Hollings Cancer Center, Carcinoma	Stem Cell Exhaustion	Intermediate carcinoma may be a distinct type of primary liver carcinoma, morphologically and phenotypically intermediate between HCC and CC, which originates from transformed hepatic progenitor cells.	14739102
Peripheral Stem Cell Transplantation, Amyloidosis	Stem Cell Exhaustion	Superior survival in primary systemic amyloidosis patients undergoing peripheral blood stem cell transplantation: a case-control study.	14739213
Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	High-dose chemotherapy with peripheral blood stem cell transplantation (PBSCT) has been associated with higher response rates and seemingly higher overall survival than standard chemotherapy.	14739213
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Patients with relapsed or primary refractory diffuse large B-cell lymphoma (DLBCL) who achieve complete response (CR) before autologous stem cell transplantation (ASCT) generally have better outcomes than those who achieve only partial response (PR).	14739217
Acute GVH disease	Stem Cell Exhaustion	Increased immune transcript levels are correlated with acute graft-versus-host disease and cytomegalovirus response after allogeneic stem cell transplantation.	14742980
Bacteremia	Stem Cell Exhaustion	Bacteremia after hematopoietic stem cell transplantation: incidence and predictive value of surveillance cultures.	14743196
Rheumatoid Arthritis, Hematopoietic stem cells	Stem Cell Exhaustion	Impaired bone marrow hematopoietic progenitor cell function in rheumatoid arthritis patients candidated to autologous hematopoietic stem cell transplantation.	14743200
Rheumatoid Arthritis	Stem Cell Exhaustion	These observations may identify the biological risk factors for impaired mobilization and/or engraftment when RA patients are candidates for autologous hematopoietic stem cell grafting.	14743200
Traumatic	Stem Cell Exhaustion	Proliferation, migration, and differentiation of human neural stem/progenitor cells after transplantation into a rat model of traumatic brain injury.	14743917
Wounds and Injuries	Stem Cell Exhaustion	In this study, long-term cultured and cryopreserved cells were transplanted into the traumatically injured rat brain to evaluate the potential for human neural stem/progenitor cells to survive and differentiate following traumatic injury.	14743917
Hematologic Neoplasms	Stem Cell Exhaustion	Possibility of long-term remission in patients with advanced hematologic malignancies after reduced intensity conditioning regimen (RIC) and allogeneic stem cell transplantation.	14745426
Neoplasms	Stem Cell Exhaustion	Because of residual vital tumor cells, a second surgical tumour reduction followed by high-dose chemotherapy with autologous stem-cell support was performed.	14750051
Lymphoma, Non-Hodgkin, Familial, Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	We evaluated the results of high-dose chemotherapy and autologous hematopoietic stem cell transplantation in patients with diffuse aggressive non-Hodgkin lymphoma (NHL) in first relapse (Rel 1) or second complete remission (CR 2).	14750077
Aggressive course	Stem Cell Exhaustion	High-dose chemotherapy and autologous hematopoietic stem cell transplantation for patients with diffuse aggressive NHL in CR 2 or Rel 1 resulted in better outcome for patients with chemotherapy-sensitive disease, longer relapse-free intervals, and age <40 years.	14750077
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Primitive hematopoietic stem cells shows a polyclonal pattern in myelodysplastic syndromes.	14754602
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Clonal hematopoiesis is the hallmark of myelodysplastic syndromes, but the role played by pluripotent stem cells and progenitor cells in these disorders remains unclear.	14754602
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	In myelodysplastic syndromes, hematopoiesis may be dominated by a neoplastic clone by virtue of its biological advantage over a residual polyclonal, probably still normal, population of immature stem cells still able to grow in vitro.	14754602
Graft-vs-Host Disease, Malignant Neoplasms	Stem Cell Exhaustion	Low-dose alemtuzumab (Campath) in myeloablative allogeneic stem cell transplantation for CD52-positive malignancies: decreased incidence of acute graft-versus-host-disease with unique pharmacokinetics.	14755312
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Alemtuzumab is effective in reducing the risk of acute graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (ASCT).	14755312
Antiphospholipid Syndrome, Myocardial necrosis	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation for refractory antiphospholipid syndrome causing myocardial necrosis.	14755313
Autoimmune Diseases, Lupus Erythematosus, Encephalitis, St. Louis	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation (HSCT) is currently being evaluated as a treatment for autoimmune diseases, including systemic lupus erythematosus (SLE), that are associated with a very severe prognosis.	14755313
Hematological Disease	Stem Cell Exhaustion	To evaluate the feasibility of reduced intensity stem cell transplantation (RIST) with bone marrow from a matched unrelated donor (MUD), we retrospectively investigated 20 patients with hematological disorders who received RIST in the Tokyo SCT consortium from January 2000 to October 2002.	14755317
Lymphoma	Stem Cell Exhaustion	This is the first report with this type of lymphoma in a boy less than 15 years old treated with hematopoietic stem cell transplantation (HSCT).	14755380
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Stem Cell Exhaustion	Intensive chemotherapy and autologous stem-cell transplantation plus rituximab is superior to conventional chemotherapy for newly diagnosed advanced stage mantle-cell lymphoma: a matched pair analysis.	14760123
Medial collateral ligament, Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Stem Cell Exhaustion	The outcome of 20 patients with newly diagnosed mantle-cell lymphoma (MCL) treated on a prospective trial of autologous stem-cell transplantation (ASCT) and rituximab immunotherapy was compared with the outcome of 40 matched historical control patients treated with standard combination chemotherapy.	14760123
Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH) arises from a somatic mutation of the PIG-A gene in a hematopoietic stem cell and the subsequent production of blood cells with a deficiency of surface proteins that protect the cells against attack by the complement system.	14762182
Childhood Breast Carcinoma	Stem Cell Exhaustion	High-dose chemotherapy and stem cell transplantation does not improve relapse-free or overall survival in women with high-risk breast cancer.	14766131
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Epstein-Barr virus-associated posttransplant lymphoproliferative disorder after a cord blood stem cell transplantation presenting with pulmonary nodules.	14767205
EBV-Related Lymphoproliferative Disorder	Stem Cell Exhaustion	Sixteen months after a cord blood stem cell transplantation, a 6-year-old girl was diagnosed with Epstein-Barr virus-associated posttransplant lymphoproliferative disorder (EBV-PTLD).	14767205
Prostate carcinoma	Stem Cell Exhaustion	Prostate stem cell antigen expression is associated with gleason score, seminal vesicle invasion and capsular invasion in prostate cancer.	14767283
Toxic effect, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Successful treatment of primary refractory acute myeloid leukemia with megadose stem cell transplantation, bone marrow boost and reduced intensity conditioning avoiding chronic graft vs. host disease and severe late toxicity.	14870901
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Therefore, we conclude that reduced intensity conditioning in combination with allogeneic megadose stem cell transplantation and bone marrow boost may have helped to achieve cure from primary refractory AML as well as a good quality of life for this boy.	14870901
Hemoglobinuria, Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	Paroxysmal nocturnal haemoglobinuria (PNH) is characterized by the expansion of phosphatidylinositol glycan class A (PIG-A) defective haematopoietic cells, probably due to the immune-mediated alterations of the bone marrow environment selecting PIG-A- stem cells.	14871257
Deficit	Stem Cell Exhaustion	Most quality-of-life (QoL) studies in autologous Peripheral Blood Stem Cell Transplantation (PBSCT) are descriptive and concentrate on symptom severity and functional deficits.	14872530
Tumor necrosis	Stem Cell Exhaustion	Interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha may affect the growth and differentiation of erythroid progenitor cells.	14962250
Ann Arbor Stage I Nasal Type NK/T-Cell Lymphoma	Stem Cell Exhaustion	Effective high-dose chemotherapy combined with CD34+-selected peripheral blood stem cell transplantation in a patient with cutaneous involvement of nasal NK/T-cell lymphoma.	14962252
Ann Arbor Stage I Nasal Type NK/T-Cell Lymphoma	Stem Cell Exhaustion	We suggest that marrow-ablative chemotherapy facilitated by autologous stem cell transplantation should be considered part of the primary therapy for subjects with a poor prognosis for nasal NK/T-cell lymphoma with cutaneous involvement.	14962252
Lymphoma, Non-Hodgkin, Familial, Hodgkin Disease, Lymphoma, Non-Hodgkin, HD Term Type	Stem Cell Exhaustion	We investigated the feasibility, tolerability and efficacy of an outpatient schedule of dexamethasone, cytarabine and cisplatin (DHAP), followed by peripheral blood progenitor cell autografting as salvage treatment in patients with high grade (HG), low grade (LG) non-Hodgkin's lymphoma (NHL) and Hodgkin's Disease (HD).	14962257
Primary Myelofibrosis	Stem Cell Exhaustion	Except rare instances of allogeneic stem cell transplantation, treatment of idiopathic myelofibrosis (IMF) is only palliative and based on cytostatic treatment (hydroxyurea and anagrelide), androgen therapy, steroids and splenectomy.	14962263
PAFAH1B1 wt Allele	Stem Cell Exhaustion	These findings support the concept that human MDS originates in a transplantable multilineage hematopoietic stem cell whose genetic alteration may affect patterns of differentiation and responsiveness to hematopoietic growth factors.	14962905
Multiple Myeloma	Stem Cell Exhaustion	We report on 12 cases (9 males and 3 females), median age 56 years old (range 41-65 years old) who underwent autologous peripheral stem cell transplantation for multiple myeloma and received thalidomide as maintenance therapy post-transplantation.	14965866
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	[Mobilization of stem cells by granulocyte colony-stimulating factor for the regeneration of myocardial tissue after myocardial infarction].	14970913
Lymphoma	Stem Cell Exhaustion	Nonmyeloablative stem cell transplantation for lymphoma.	14970933
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	High-dose chemotherapy and allogeneic stem cell transplantation is a potentially curative therapy for younger patients with non-Hodgkin's lymphoma (NHL).	14970933
Pregnancy Complications, Infectious, Childhood Breast Carcinoma, Multiple Myeloma	Stem Cell Exhaustion	Hemopoietic recovery and infectious complications in breast cancer and multiple myeloma after autologous CD34+ cell-selected peripheral blood progenitor cell transplantation.	14979484
Infection	Stem Cell Exhaustion	Autografting with CD34+ cell-selected peripheral blood progenitor cells (PBPC) is often associated with a prolonged recovery time and a higher incidence of infections.	14979484
Leukemia, Myelocytic, Acute, Infectious Lung Disorder	Stem Cell Exhaustion	Successful treatment with nonmyeloablative allogeneic hematopoietic stem cell transplantation in a patient with acute myeloid leukemia complicated with pulmonary infection.	14979485
Leukemia, Myelocytic, Acute, Infectious Lung Disorder	Stem Cell Exhaustion	We describe the case of a 48-year-old man with acute myeloid leukemia complicated with pulmonary infection that was successfully treated by nonmyeloablative allogeneic peripheral blood stem cell transplantation with conditioning by low-dose total body irradiation and fludarabine.	14979485
Multiple Myeloma	Stem Cell Exhaustion	Deletion of chromosome band 13q14 as detected by fluorescence in situ hybridization is a prognostic factor in patients with multiple myeloma who are receiving allogeneic dose-reduced stem cell transplantation.	14982868
Cessation of life	Stem Cell Exhaustion	Concerning overall survival, 2 or more cycles of prior high-dose chemotherapy were associated with a significantly higher probability of death (HR, 2.48; 95% CI, 1.19-5.17; P =.02), while patients with deletion 13q had a nearly 2 times higher risk of death (HR, 1.94; 95% CI, 0.95-3.98; P =.07) after dose-reduced allogeneic stem cell transplantation.	14982868
Unknown (origin) (qualifier value), Specialty Type - cancer, Purpura, Thrombotic Thrombocytopenic	Stem Cell Exhaustion	ADAMTS13 level at presentation was lower than 5% in 16 of 20 patients with idiopathic TTP and in none of 17 patients with TTP associated with hematopoietic stem cell transplantation, cancer, drugs, or pregnancy (P <.00001).	14982878
Arteriosclerosis Obliterans	Stem Cell Exhaustion	Autologous transplantation of peripheral blood stem cells as an effective therapeutic approach for severe arteriosclerosis obliterans of lower extremities.	14983238
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Extremely short survival periods were noted for each CNS PTLD that followed peripheral blood stem cell transplantation.	14983939
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Fresh leukaemic cells from five patients with acute myeloid leukaemia (AML) were isolated and retrovirally transduced with OX40L during the culture with a combination of cytokines from stem cell factor, fms-like tyrosine kinase (Flt)-3 ligand, granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin-4 (IL-4) and TNF-alpha.	14984494
Hematological Disease	Stem Cell Exhaustion	Sources for allogeneic stem cells for patients with haematological disorders lacking a histocompatible sibling donor include matched unrelated donor (MUD) and umbilical cord blood (UCB).	14984500
Encephalitis	Stem Cell Exhaustion	Acanthamoeba castellani encephalitis following partially mismatched related donor peripheral stem cell transplantation.	14987204
Acanthamoeba, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We describe a case of Acanthamoeba encephalitis in a 45-year-old Caucasian male with acute myelogenous leukemia, who was 140 days status post partially mismatched related donor peripheral blood stem cell transplant.	14987204
Coronary Arteriosclerosis, Exercise-induced lactic acidemia	Stem Cell Exhaustion	Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemia.	14988094
Ischemia	Stem Cell Exhaustion	The concept of neovascularization in response to tissue ischemia has been extended by the finding of postnatal vasculogenesis initiated by endothelial progenitor cells (EPCs).	14988094
Aortitis	Stem Cell Exhaustion	We report the case of a 55 years old woman who developed acute aortitis of the descending aorta after G-CSF (granulocyte-colony stimulating factor) injections for blood stem cells graft.	14990294
Hematologic Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	In conclusion, particularly in older donors and donors with potential for familial malignancies, more screening investigations including bone marrow aspiration may be reasonable to investigate for occult hematological malignancies prior to stem cell donation.	14990983
Graft-vs-Host Disease	Stem Cell Exhaustion	A novel reduced intensity regimen for allogeneic hematopoietic stem cell transplantation associated with a reduced incidence of graft-versus-host disease.	14990986
Autoimmune reaction, Graft-vs-Host Disease	Stem Cell Exhaustion	The administration of cyclosporin A (CsA) after autologous stem cell transplantation (SCT) paradoxically elicits a systemic autoimmune syndrome that resembles graft-versus-host disease (GVHD); this is termed autologous GVHD (autoGVHD).	14993881
Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	The patient received 5 courses of VIP therapy (cisplatin, etoposide, ifosfamide) and 1 course of high-dose chemotherapy (carboplatin, etoposide, cyclophospamide) with peripheral blood stem cell transplantation.	14997765
Adenocarcinoma, Neoplasms	Stem Cell Exhaustion	These mixed or 'composite' tumours seem to be derived from a multipotential stem cell capable of bidirectional differentiation and have a worse prognosis than ordinary adenocarcinoma.	15000285
Paroxysmal nocturnal hemoglobinuria, Aplastic Anemia	Stem Cell Exhaustion	Similar immune mechanisms have been suggested to operate in aplastic anemia (AA) and paroxysmal nocturnal hemoglobinuria (PNH), and the presence of PNH clones in AA may indicate that an immune reaction directed against hematopoietic stem cells may be responsible for the immune selection pressure leading to PNH evolution.	15003311
Severe congenital neutropenia	Stem Cell Exhaustion	Umbilical cord blood stem cell transplantation from unrelated HLA-matched donor in an infant with severe congenital neutropenia.	15004540
Severe congenital neutropenia	Stem Cell Exhaustion	We report here a 6-month-old boy with severe congenital neutropenia (SCN) successfully treated by cord blood stem cell transplantation (CBSCT) from an unrelated donor.	15004540
Blast Phase	Stem Cell Exhaustion	Complete remission from chronic myelogenous leukemia--blastic crisis caused by reduced intensity stem cell transplantation following partial remission due to imatinib.	15005255
Tuberculosis	Stem Cell Exhaustion	Tuberculosis in hematopoietic stem cell transplant recipients in Korea.	15005349
Cellular Immunity, Communicable Diseases	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) results in impaired cell-mediated immunity, which subsequently increases the risk of infection from bacterial, fungal, and viral pathogens.	15005349
Multiple Myeloma	Stem Cell Exhaustion	Favourable results with a single autologous stem cell transplant following conditioning with busulphan and cyclophosphamide in patients with multiple myeloma.	15009065
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Both single and tandem cycles of high dose therapy and autologous peripheral blood stem cell transplantation (ASCT) have been shown to improve survival in multiple myeloma (MM) patients.	15009065
Multiple Myeloma	Stem Cell Exhaustion	The t(4;14) is associated with poor prognosis in myeloma patients undergoing autologous stem cell transplant.	15015970
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The frequency and prognostic relevance of translocations t(11;14) and t(4;14), the most common translocations involving the immunoglobulin heavy chain (IgH) gene in multiple myeloma (MM), were investigated in 128 patients treated with intensive chemotherapy and autologous stem cell transplant.	15015970
Graft-vs-Host Disease	Stem Cell Exhaustion	Gut graft-versus-host disease (GVHD) contributes significantly to lethality after allogeneic hematopoietic stem-cell transplantation (HSCT).	15017608
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	A 5-year-old boy with acute lymphoblastic leukaemia (ALL) received a haematopoietic stem cell transplant (HSCT) from his father and was monitored for the presence of respiratory viruses.	15018862
Congestive heart failure, Myocardial Ischemia	Stem Cell Exhaustion	Autologous peripheral stem cell transplantation in patients with congestive heart failure due to ischemic heart disease.	15019658
Neoplastic disease, Hyperplasia	Stem Cell Exhaustion	In conclusion, we suggest that normal, hyperplastic and neoplastic breast epithelial cells expressing the anti-apoptotic protein Bcl-2 are immature cells that ought to form part of the stem-cell subpopulation, which is committed to the development and to the maintenance of the normal gland and which gives rise to hyperplastic and neoplastic disorders when its proliferation is deregulated.	15024706
nervous system disorder	Stem Cell Exhaustion	[What are the therapeutic hopes for stem cell in neurological diseases?].	15025264
nervous system disorder	Stem Cell Exhaustion	In this lecture, the author reviews the biological properties of different stem cells types in order to be used in cerebral graft in several neurological diseases.	15025264
Optic Atrophy, Hereditary, Leber	Stem Cell Exhaustion	Several point mutations of mtDNA, including secondary point mutations for Leber's hereditary optic neuropathy, occur in one bone marrow and may synergically affect bone marrow stem cells by an apoptotic pathway.	15026331
Multiple Myeloma	Stem Cell Exhaustion	Psychosocial adjustment and quality of life among multiple myeloma patients undergoing evaluation for autologous stem cell transplantation.	15034542
Malignant Neoplasms, Multiple Myeloma	Stem Cell Exhaustion	Stem cell transplantation has assumed a prominent place in the treatment of multiple myeloma, but relative to patients with other malignancies there is surprisingly little information about the adjustment difficulties and quality-of-life changes that these patients experience.	15034542
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Factors affecting progenitor cell mobilisation in patients with non-Hodgkin's lymphoma (NHL) are incompletely understood.	15034543
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Rituximab-related late-onset neutropenia after autologous stem cell transplantation for aggressive non-Hodgkin's lymphoma.	15034544
Myocardial Ischemia	Stem Cell Exhaustion	Cell therapy with bone marrow-derived stem/progenitor cells is a novel option for improving neovascularization and cardiac function in ischemic heart disease.	15037527
Coronary heart disease	Stem Cell Exhaustion	Circulating endothelial progenitor cells in patients with coronary heart disease are impaired with respect to number and functional activity.	15037527
Multiple Myeloma	Stem Cell Exhaustion	The dose of infused lymphocytes in the autograft directly correlates with clinical outcome after autologous peripheral blood hematopoietic stem cell transplantation in multiple myeloma.	15042106
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Absolute lymphocyte count at day 15 (ALC-15) after autologous peripheral blood hematopoietic stem cell transplantation (APHSCT) is an independent prognostic factor for survival in multiple myeloma (MM); however, factors affecting ALC-15 in MM remain unknown.	15042106
Peripheral Stem Cell Transplantation, Amyloidosis	Stem Cell Exhaustion	Prognostication of survival using cardiac troponins and N-terminal pro-brain natriuretic peptide in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation.	15044258
Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	Pilot data suggest survival is better in patients undergoing peripheral blood stem cell transplantation (PBSCT), but the selection process makes the apparent benefit suspect.	15044258
Lymphoma	Stem Cell Exhaustion	Graft-versus-lymphoma (GVL) effect has been described in patients with malignant lymphoma after allogeneic stem cell transplantation (alloSCT).	15045825
Vena cava syndrome	Stem Cell Exhaustion	Since the patient did not respond to various combination chemotherapies and further developed superior vena cava syndrome, allogeneic peripheral blood stem cell transplantation (PBSCT) from a HLA-identical brother was carried out after a myeloablative TBI/CY-based conditioning regimen.	15045825
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	[Nonmyeloablative allogeneic stem cell transplantation for a 70-year-old woman with relapsed acute myelogenous leukemia].	15045828
Primary intraocular non-Hodgkin malignant lymphoma	Stem Cell Exhaustion	[Results of intensive chemotherapy followed by hematopoietic stem-cell rescue in 22 patients with refractory or recurrent primary CNS lymphoma or intraocular lymphoma].	15047459
Legionnaires Disease	Stem Cell Exhaustion	when one definite or one possible case of laboratory-confirmed health-care--associated Legionnaires disease is identified in an inpatient hemopoietic stem-cell transplant (HSCT) recipient or in two or more HSCT recipients who had visited an outpatient HSCT unit during all or part of the 2-10 day period before illness onset.	15048056
Infection	Stem Cell Exhaustion	In conclusion, the possible efficacy of intravenous Ribavirin in controlling RSV or adenovirus infections after allogeneic stem cell transplantations should be evaluated in prospective clinical trials.	15048064
Leukemia, Myelomonocytic, Chronic, Primary Myelofibrosis, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	In all, 20 patients with a median age of 51 years underwent allogeneic hematopoietic stem cell transplantation (HSCT) for myelofibrosis (n=5), chronic myelomonocytic leukemia (CMML) (n=8) and Philadelphia (Ph) chromosome-negative/BCR-ABL-negative chronic myeloid leukemia (CML) (n=7) in our institution.	15048141
Myeloid neoplasm	Stem Cell Exhaustion	Reduced-intensity stem cell transplantation from an HLA-identical sibling donor in patients with myeloid malignancies.	15048142
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	The purpose of this study was to evaluate the feasibility and efficacy of allogeneic hematopoietic stem cell transplantation with a reduced-intensity regimen (RIST) in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).	15048142
Burn, CTCAE, Ocular Cicatricial Pemphigoid, Schwartz-Jampel Syndrome, Stevens-Johnson Syndrome	Stem Cell Exhaustion	In 7 eyes Limbal Stem Cells Deficiency (LSCD) resulted from chemical burn, in 2 eyes from ocular cicatricial pemphigoid, in one eye from Stevens-Johnson syndrome (SJS).	15049259
Congenital anomaly of eyelid, Tissue Adhesions	Stem Cell Exhaustion	The prognosis for stem cells grafting is definitely worse when eyelid anomaly and adhesions exist.	15049259
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	An acute myeloid leukaemia was diagnosed in 1997 which arose from a myelodysplasia, after performance of a peripheral allogenic blood stem cell transplantation.	15052528
Gastrointestinal Stromal Tumors	Stem Cell Exhaustion	GISTs are characterized by the expression of the KIT protein, a transmembrane tyrosine kinase receptor for stem-cell factor.	15053476
Malignant neoplasm of ovary	Stem Cell Exhaustion	Dose intense triplet chemotherapy with gemcitabine, carboplatin, paclitaxel with peripheral blood progenitor cell support for six cycles in advanced epithelial ovarian cancer.	15054448
Neutropenia, Aspergillosis	Stem Cell Exhaustion	Prospective clinical evaluation of a LightCycler-mediated polymerase chain reaction assay, a nested-PCR assay and a galactomannan enzyme-linked immunosorbent assay for detection of invasive aspergillosis in neutropenic cancer patients and haematological stem cell transplant recipients.	15059142
Leukemia, Myelocytic, Acute, Multilineage Dysplasia Present, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Reduced-intensity allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome and acute myeloid leukemia with multilineage dysplasia using fludarabine, busulphan, and alemtuzumab (FBC) conditioning.	15059843
Respiratory syncytial virus	Stem Cell Exhaustion	Respiratory syncytial virus-related pneumonia after stem cell transplantation successfully treated with palivizumab and steroid therapy.	15061675
Hodgkin Disease, Pneumonia, Interstitial	Stem Cell Exhaustion	A case is reported of a 56-y-old woman with a second relapse of Hodgkin's disease who early developed after autologous stem cell transplantation (ASCT) a severe RSV-related interstitial pneumonia successfully treated with 1-d intravenous palivizumab 8 mg/kg plus low-dose systemic steroid therapy.	15061675
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	The recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT) often develop acute graft-versus-host disease (aGVHD), which is closely related to morbidity and mortality.	15064686
Hematologic Neoplasms	Stem Cell Exhaustion	Inadequate stem cell mobilization is seen in approximately 25% of patients undergoing autotransplantation for hematologic malignancies.	15064690
Graft-vs-Host Disease, Toxic effect	Stem Cell Exhaustion	In an attempt to decrease toxicity in high-risk patients undergoing unrelated donor hematopoietic stem cell transplantation (URD HSCT), we tested a combination of cyclosporine (CSP) and mycophenolate mofetil (MMF) as graft-versus-host disease (GVHD) prophylaxis with the reduced-intensity conditioning regimen fludarabine/melphalan (Flu/Mel).	15064696
Anemia, Rheumatoid Arthritis, Hematopoietic stem cells, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We could demonstrate that hTERT is differentially expressed in various haematologic stem cell disorders with significant higher levels in refractory anemia (RA) and chronic myeloid leukemia (CML) compared to other haematopoietic stem cell disorders and non-neoplastic haematopoiesis which may be used as a prognostic indicator in these entities.	15068898
Multiple Myeloma	Stem Cell Exhaustion	Cellular immune responses in multiple myeloma patients with treatment-induced cytopenia early after high-dose chemotherapy and autologous peripheral blood stem cell transplantation.	15068899
Multiple Myeloma	Stem Cell Exhaustion	multiple myeloma patients receiving high-dose melphalan and autologous peripheral blood stem cell transplantation; (ii).	15068899
Tumor necrosis	Stem Cell Exhaustion	The cytokine response profiles as determined by [(3)H]-thymidine incorporation assay were: 2-to-12 fold growth stimulation of MUTZ-11 by GM-CSF, IFN-alpha (interferon), IFN-beta, IFN-gamma, IL-3 and SCF (stem cell factor); growth inhibition by TGF-beta1 (transforming growth factor), TNF-alpha (tumor necrosis factor) and TNF-beta.	15068904
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	A 22-year-old man with chronic myeloid leukemia (CML) received fractionated total body irradiation (TBI) (1440cGy) and etoposide (60 mg/kg) followed by infusion of 10 x 10(6) /kg CD34+ selected stem cells from his mother.	15068908
Gastrointestinal Stromal Tumors	Stem Cell Exhaustion	We monitored the serum levels of KIT, KIT ligand (stem cell factor, SCF), and the vascular endothelial growth factor (VEGF) in patients with advanced GISTs treated with imatinib in a prospective randomized trial.	15070666
Amyloidosis	Stem Cell Exhaustion	Association of melphalan and high-dose dexamethasone is effective and well tolerated in patients with AL (primary) amyloidosis who are ineligible for stem cell transplantation.	15070667
Toxic effect, Amyloidosis	Stem Cell Exhaustion	The most efficient therapeutic approach for immunoglobulin light chain amyloidosis (AL) is autologous stem cell transplantation (ASCT); however, the toxicity of ASCT limits its feasibility to a minority of patients.	15070667
Supratentorial Embryonal Tumor, Not Otherwise Specified, Medulloblastoma	Stem Cell Exhaustion	High-dose chemotherapy with autologous stem cell rescue as first line of treatment in young children with medulloblastoma and supratentorial primitive neuroectodermal tumors.	15072454
Supratentorial Embryonal Tumor, Not Otherwise Specified, Medulloblastoma	Stem Cell Exhaustion	In order to improve the dismal prognosis of patients younger than 4 years old with medulloblastoma and supratentorial primitive neuroectodermal tumors (stPNET) seven young children were treated with high-dose chemotherapy (HDCT) and autologous stem cell rescue in our center.	15072454
Alopecia universalis	Stem Cell Exhaustion	Complete remission of alopecia universalis after allogeneic hematopoietic stem cell transplantation.	15073031
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	This case report is on a 40-year-old male patient with chronic myeloid leukemia (CML) receiving an allogeneic hematopoietic stem cell transplantation (HSCT) in first chronic phase from an HLA-identical sibling brother.	15073031
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Once-daily intravenous busulfan and fludarabine: clinical and pharmacokinetic results of a myeloablative, reduced-toxicity conditioning regimen for allogeneic stem cell transplantation in AML and MDS.	15073038
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Postulating favorable antileukemic effect with improved safety, we used intravenous busulfan and fludarabine as conditioning therapy for allogeneic hematopoietic stem cell transplantation (HSCT) for acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS).	15073038
Autoimmune Diseases	Stem Cell Exhaustion	Disappearance of diffuse calcinosis following autologous stem cell transplantation in a child with autoimmune disease.	15077134
Ischemia, Pulmonary Hypertension	Stem Cell Exhaustion	A peripheral blood stem cell autograft was offered when she developed pulmonary hypertension and digital ischemia at the age of 16 years.	15077134
Pulmonary Hypertension	Stem Cell Exhaustion	Despite initial remission following autologous stem cell transplantation, his disease relapsed and he died from pulmonary hypertension.	15080269
Pancreatic carcinoma	Stem Cell Exhaustion	Stem cell factor and macrophage-colony stimulating factor in patients with pancreatic cancer.	15080556
Specialty Type - cancer	Stem Cell Exhaustion	Stem cell factor (SCF) and macrophage-colony stimulating factor (M-CSF) have assumed an increasing importance in cancer biology.	15080556
Pancreatic carcinoma	Stem Cell Exhaustion	Nonmyeloablative allogeneic stem cell transplantation for patients with unresectable pancreatic cancer.	15084986
Neoplasms, Pancreatic carcinoma	Stem Cell Exhaustion	To clarify whether nonmyeloablative allogeneic stem cell transplantation (NST) can produce the graft versus tumor (GVT) effect in patients with pancreatic cancer.	15084986
Kidney, Acute Undifferentiated Leukemia	Stem Cell Exhaustion	Kidney, blood, and endothelium: developmental expression of stem cell leukemia during nephrogenesis.	15086455
Acute Undifferentiated Leukemia	Stem Cell Exhaustion	Recently, we have analyzed global gene expression during human nephrogenesis and observed up-regulation of stem cell leukemia (SCL), a transcription factor critical for hematopoietic and endothelial lineage specification.	15086455
HLA-DPB1 gene, Acute GVH disease	Stem Cell Exhaustion	Hla-DPB1 mismatch in HLA-A-B-DRB1 identical sibling donor stem cell transplantation and acute graft-versus-host disease.	15087781
Graft-vs-Host Disease	Stem Cell Exhaustion	A single HLA-DPB1 mismatch increases the risk of aGVHD after sibling donor stem cell transplantation.	15087781
Primary Myelofibrosis	Stem Cell Exhaustion	Overexpression of FK506 binding protein 51 (FKBP51) in megakaryocytic progenitor cells generated from purified CD34+ cells in patients with idiopathic myelofibrosis (IMF) has been demonstrated.	15089760
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Nonablative versus reduced-intensity conditioning regimens in the treatment of acute myeloid leukemia and high-risk myelodysplastic syndrome: dose is relevant for long-term disease control after allogeneic hematopoietic stem cell transplantation.	15090449
Graft-vs-Host Disease	Stem Cell Exhaustion	To assess a possible contribution of NOD2/CARD15 mutations to graft-versus-host disease (GvHD) and complications following allogeneic stem cell transplantation, we retrospectively typed DNA from donor/recipient pairs in 169 consecutive patients receiving transplants from related or unrelated donors.	15090455
Hodgkin Disease, Lymphoma	Stem Cell Exhaustion	Phase I study of involved-field radiotherapy preceding autologous stem cell transplantation for patients with high-risk lymphoma or Hodgkin's disease.	15093918
Hodgkin Disease, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	This Phase I study was designed to evaluate the tolerability of involved-field radiotherapy (IFRT) to areas of persistent disease in patients with high-risk Hodgkin's disease and non-Hodgkin's lymphomas before autologous stem cell transplantation (ASCT).	15093918
Gastrointestinal mucositis	Stem Cell Exhaustion	The aim of this study was to assess the efficacy of fentanyl TTS in treating oral mucositis pain in 75 adult hematopoietic stem cell transplant (HSCT) patients.	15094750
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)	Stem Cell Exhaustion	This study has compared the expression of endothelin (ET)-1, the ET-1 receptor (ET(B)R), granulocyte macrophage colony stimulating factor (GM-CSF), stem cell factor (SCF), the SCF receptor (KIT protein), tyrosinase, and S100 alpha between lesional and non-lesional vitiligo epidermis.	15095274
Hypercholesterolemia	Stem Cell Exhaustion	Number and activity of endothelial progenitor cells from peripheral blood in patients with hypercholesterolaemia.	15099190
Malignant Testicular Non-Seminomatous Germ Cell Tumor	Stem Cell Exhaustion	We reported three cases (42, 20 and 18-year-old men) of advanced nonseminomatous testicular germ cell cancer treated by salvage high-dose chemotherapy (HDC) supported by peripheral blood stem cell autotransplantation.	15101160
Pericarditis, CTCAE	Stem Cell Exhaustion	Pericarditis associated with Epstein-Barr virus reactivation in a patient following allogeneic peripheral blood stem cell transplantation from an HLA genotypic 1-locus mismatched sibling donor.	15101730
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 31-year-old woman with acute myeloblastic leukemia (AML) underwent allogeneic peripheral blood stem cell transplant (PBSCT).	15101730
Pericarditis, CTCAE	Stem Cell Exhaustion	This is the first reported case of pericarditis associated with EBV reactivation after allogeneic-stem cell transplantation (allo-SCT).	15101730
Human Platelet Antigens, Graft-vs-Host Disease	Stem Cell Exhaustion	Human platelet antigen systems in allogeneic peripheral blood progenitor cell transplantation: effect of human platelet antigen mismatch on platelet engraftment and graft-versus-host disease.	15104661
Global Stable Disease in Lymph Nodes	Stem Cell Exhaustion	The main aim of this study was to investigate the patients' self-reported symptom occurrence, symptom intensity (SI), and symptom distress (SD) from admission for stem-cell transplantation (SCT) until discharge from the ward.	15108952
ISS Stage III Plasma Cell Myeloma	Stem Cell Exhaustion	A cost-utility analysis comparing intensive chemotherapy alone to intensive chemotherapy followed by myeloablative chemotherapy with autologous stem-cell rescue in newly diagnosed patients with stage II/III multiple myeloma; a prospective randomised phase III study.	15110879
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	A prospective randomised phase III study in patients < or =65 years old with previously untreated multiple myeloma (MM), intensive chemotherapy followed by myeloablative chemotherapy and autologous stem-cell rescue was compared with intensive chemotherapy alone.	15110879
Multiple Myeloma	Stem Cell Exhaustion	Cost-effectiveness of myeloma therapy after 3 years of follow up seems not to be favoured by myeloablative treatment with autologous stem-cell rescue.	15110879
Hematologic Neoplasms	Stem Cell Exhaustion	Factors influencing haematological recovery following high-dose chemotherapy and peripheral stem-cell transplantation for haematological malignancies; 1-year analysis.	15110884
Hematologic Neoplasms	Stem Cell Exhaustion	Peripheral blood counts and factors influencing haematological recovery in 98 patients with a relapse-free survival of > or =1 year treated with high-dose chemotherapy (HDC) and peripheral stem-cell transplantation (PSCT) for haematological malignancies were analysed.	15110884
Acute lymphocytic leukemia	Stem Cell Exhaustion	He attained remission with acute lymphoblastic leukemia-type chemotherapy and then successfully received a non-T-cell-depleted allogeneic stem cell transplantation (allo-SCT) with his mother's two loci-mismatched donor cells.	15111787
Acute GVH disease	Stem Cell Exhaustion	Chimerism studies in HLA-identical nonmyeloablative hematopoietic stem cell transplantation point to the donor CD8(+) T-cell count on day + 14 as a predictor of acute graft-versus-host disease.	15111933
Hematologic Neoplasms	Stem Cell Exhaustion	We have investigated the development of donor chimerism in granulocytes and CD4(+) and CD8(+) T cells in blood and bone marrow of 24 patients with hematologic malignancies who received HLA-identical sibling peripheral blood stem cell grafts after conditioning with fludarabine and 2 Gy of total body irradiation.	15111933
Neurotoxicity Syndromes, Necrosis	Stem Cell Exhaustion	The presentations were (1) Characterization of Synaptic Loss in Cerebella of Mature and Senescent Rats after Lengthy Chronic Ethanol Consumption, (2) Ethanol Withdrawal Both Causes Neurotoxicity and Inhibits Neuronal Recovery Processes in Rat Organotypic Hippocampal Cultures, (3) Binge Drinking-Induced Brain Damage: Genetic and Age Related Effects, (4) Binge Ethanol-Induced Brain Damage: Involvement of Edema, Arachidonic Acid and Tissue Necrosis Factor alpha (TNFalpha), and (5) Cyclic AMP Cascade, Stem Cells and Ethanol.	15112943
Acute GVH disease	Stem Cell Exhaustion	Safety and efficacy of denileukin diftitox in patients with steroid-refractory acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.	15113758
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	We have assessed autologous stem cell transplantation after treatment with fludarabine in previously untreated patients with chronic lymphocytic leukemia (CLL).	15117764
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	In animal studies, myocardial infarction attracted bone marrow stem cells and enhanced their differentiation into cardiomyocytes.	15120885
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Based on these findings, we hypothesised that myocardial infarction stimulates the invasion of progenitor cells and their differentiation into endothelial and cardiac cells in the human heart.	15120885
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Myocardial infarction enhances the invasion of extracardiac progenitor cells and their regeneration of endothelial cells.	15120885
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myeloid leukemia (CML) arises from the malignant transformation of a hematopoietic stem cell (HSC) that gives rise to functionally defective progeny, including primitive and relatively mature progenitor cells (HPC).	15120942
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	In the present study, we have separated two different subpopulations of CD34(+) cells from CML marrow: Population I, enriched for CD34(+) Lin(-) cells; and Population II, enriched for CD34(+) CD36(-) CD38(-) CD45RA(-) Lin(-) cells, and assessed their progenitor cell content as well as their capacity to proliferate and expand in response to a combination of hematopoietic cytokines in serum- and stroma-free long-term liquid cultures.	15120942
Ovarian Carcinoma	Stem Cell Exhaustion	Analysis of 96 patients with advanced ovarian carcinoma treated with high-dose chemotherapy and autologous stem cell transplantation.	15122311
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The German AML Cooperative Group 1999 trial asks three questions in a randomized factorial design: high-dose vs. standard-dose AraC during induction therapy; G-CSF priming vs. no G-CSF priming; and autologous stem cell transplantation vs. maintenance therapy.	15124669
Intraepithelial Neoplasia	Stem Cell Exhaustion	Limbal stem cell deficiency following topical mitomycin C treatment of conjunctival-corneal intraepithelial neoplasia.	15126170
Intraepithelial Neoplasia	Stem Cell Exhaustion	To report a case of conjunctival-corneal intraepithelial neoplasia (CCIN) in an elderly African American patient treated with topical mitomycin C and the subsequent complication of limbal stem cell deficiency.	15126170
Testicular Neoplasms	Stem Cell Exhaustion	Nestin, a neuroectodermal stem cell marker molecule, is expressed in Leydig cells of the human testis and in some specific cell types from human testicular tumours.	15127288
Neoplasms	Stem Cell Exhaustion	The possible expression of the neural stem cell marker nestin in Leydig cells and testicular tumour cells was determined by analysing the patterns of nestin expression in normal and pathological human testes by Western blot and immunohistochemical methods.	15127288
Neoplasms	Stem Cell Exhaustion	The intermediate filament protein nestin is predominantly expressed in some stem/progenitor cells and appears to be a useful molecular tool to characterise tumours originating from precursor cells of neuroectodermal and mesenchymal lineages.	15127288
Fusariosis	Stem Cell Exhaustion	Fusarium infection in hematopoietic stem cell transplant recipients.	15127334
Fusariosis	Stem Cell Exhaustion	To characterize the epidemiology and prognostic factors of invasive fusariosis in hematopoietic stem cell transplant (HSCT) recipients, the records of HSCT recipients from 9 hospitals (7 in Brazil and 2 in the United States) were retrospectively reviewed.	15127334
Hyperimmunoglobulin M syndrome	Stem Cell Exhaustion	A 3 and 1/2-yr-old boy underwent matched unrelated stem cell transplantation (SCT) for hyper-IgM syndrome.	15128425
Hypercholesterolemia	Stem Cell Exhaustion	[Effects of hypercholesterolemia on the number and activity of endothelial progenitor cells in peripheral blood].	15130408
Hypercholesterolemia	Stem Cell Exhaustion	To investigate whether hypercholesterolemia has influences on the number and activity of endothelial progenitor cells (EPCs).	15130408
Multiple Myeloma	Stem Cell Exhaustion	In total, 77 myeloma patients received either cyclophosphamide 4.5 g/m(2) (n=28) alone or with etoposide 2 g/m(2) (n=49) in a nonrandomized manner, followed by G-CSF 10 microg/kg/day for the purpose of stem cell mobilization.	15133484
Toxic effect, Multiple Myeloma	Stem Cell Exhaustion	High-dose cyclophosphamide with or without etoposide for mobilization of peripheral blood progenitor cells in patients with multiple myeloma: efficacy and toxicity.	15133484
Multiple Myeloma	Stem Cell Exhaustion	High-dose therapy and autologous stem cell transplantation for multiple myeloma poorly responsive to initial therapy.	15133489
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplant (SCT) improves survival in multiple myeloma (MM) and remains the standard of care for eligible patients.	15133489
Hyperpigmentation	Stem Cell Exhaustion	The epidermal stem cell factor is over-expressed in lentigo senilis: implication for the mechanism of hyperpigmentation.	15140230
Hyperpigmentation	Stem Cell Exhaustion	The paracrine mechanism underlying ultraviolet B (UVB)-induced hyperpigmentation in the skin may involve the stimulation of the ET-1/ET(B)R cascade as well as the stem cell factor (SCF)/SCF receptor cascade.	15140230
Transplant-Related Malignant Neoplasm, Acute GVH disease	Stem Cell Exhaustion	By multivariate analyses, the incidence of chronic GvHD was significantly increased in PBSCT, whereas the stem cell source did not affect the incidence of acute GvHD, transplant-related mortality, relapse or survival.	15142119
Hypertension, CTCAE, Hypercholesterolemia, Diabetes, Heart Diseases, Overweight, Cardiac dysfunction	Stem Cell Exhaustion	Cumulative dose of doxorubicin, male sex, older age, relapse, radiotherapy (mediastinal or total-body irradiation), autologous stem-cell transplantation, high-dose cyclophosphamide, and cardiovascular risk factors (hypertension, diabetes, hypercholesterolemia, familial history of cardiac disease, being overweight, and smoking history) were evaluated as potential risk factors for the development of cardiac dysfunction.	15143078
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Validation and extension of the EBMT Risk Score for patients with chronic myeloid leukaemia (CML) receiving allogeneic haematopoietic stem cell transplants.	15147377
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The European Group for Blood and Marrow Transplantation (EBMT) devised a scoring system to predict survival after allogeneic haematopoietic stem cell transplantation (HSCT) for chronic myeloid leukaemia (CML).	15147377
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	We report a phase II study of autologous peripheral blood stem cell transplantation with in vitro IL-2 incubation of peripheral blood stem cells and posttransplantation IL-2 in patients with recurrent or refractory non-Hodgkin lymphoma.	15148492
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Phase II study of autologous transplantation with interleukin-2-incubated peripheral blood stem cells and posttransplantation interleukin-2 in relapsed or refractory non-Hodgkin lymphoma.	15148492
Toxic effect	Stem Cell Exhaustion	Administration of IL-2-incubated peripheral blood stem cells and intensive posttransplantation IL-2 was associated with considerable but rapidly reversible toxicity.	15148492
Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	Prognostic significance of occult tumor cells in the apheresis products of patients with advanced breast cancer receiving high-dose chemotherapy and autologous hematopoietic progenitor cell support.	15148495
Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	We prospectively evaluated the prognostic significance of occult tumor cells (OTCs) contaminating the peripheral blood progenitor cell apheresis products of patients with advanced breast cancer receiving high-dose chemotherapy.	15148495
mecarzole, Childhood Breast Carcinoma, Primary malignant neoplasm	Stem Cell Exhaustion	Immunocytochemistry of peripheral blood progenitor cells was performed in 242 patients with high-risk primary breast cancer (HRPBC) and in 111 patients with metastatic breast cancer (MBC).	15148495
Ischemia	Stem Cell Exhaustion	Autologous transplantation of peripheral blood endothelial progenitor cells (CD34+) for therapeutic angiogenesis in patients with critical limb ischemia.	15153817
CLU protein, human, Ischemia	Stem Cell Exhaustion	Intramuscular injection of endothelial progenitor cells (EPCs) may constitute an alternative treatment strategy for patients with critical limb ischemia (CLI).	15153817
Neoplasms	Stem Cell Exhaustion	The tumour probably arose from pluripotential mesothelial stem cells within the splenic capsula, with subsequent mesothelial to endothelial metaplasia and neoplastic transformation.	15154584
Kidney Failure, Chronic	Stem Cell Exhaustion	Decreased number and impaired angiogenic function of endothelial progenitor cells in patients with chronic renal failure.	15155385
Kidney Failure, Chronic, Cardiovascular Diseases, Atherosclerosis, corticotropin-releasing factor, human	Stem Cell Exhaustion	Increased risk of cardiovascular disease in patients with chronic renal failure (CRF) has been explained by accelerated atherosclerosis and impaired angiogenesis, in which endothelial progenitor cells (EPCs) may play key roles.	15155385
Specialty Type - cancer	Stem Cell Exhaustion	To evaluate the effect of peripheral blood stem cell transplantation on functional capacity, and to determine the role of a mixed type, moderate intensity exercise programme in the recovery of patients after intensive cancer treatment.	15155433
Therapy-related acute myeloid leukemia and myelodysplastic syndrome	Stem Cell Exhaustion	The use of VP-16 for stem cell mobilization has been cited as a significant risk factor for the development of therapy-related myelodysplasia/leukemia (tMDS/tAML) following autologous transplantation.	15156164
Aspergillosis	Stem Cell Exhaustion	Risk factors for post-engraftment invasive aspergillosis in allogeneic stem cell transplantation.	15156166
Aspergillosis	Stem Cell Exhaustion	The majority of invasive aspergillosis (IA) in allogeneic stem cell transplantation (SCT) occurs during the post-engraftment period.	15156166
Amyloidosis	Stem Cell Exhaustion	A multicenter phase 2 trial of stem cell transplantation for immunoglobulin light-chain amyloidosis (E4A97): an Eastern Cooperative Oncology Group Study.	15156165
Amyloidosis	Stem Cell Exhaustion	Stem cell transplantation was introduced as a new therapeutic modality for amyloidosis.	15156165
Toxic effect, Amyloidosis	Stem Cell Exhaustion	The purpose of the current study was to determine the feasibility and toxicity of stem cell transplantation for amyloidosis in a cooperative group setting in which most participating institutions would have limited experience in managing the disorder.	15156165
Amyloidosis	Stem Cell Exhaustion	Stem cell transplantation for selected patients with amyloidosis is feasible in a cooperative group setting.	15156165
Marek Disease	Stem Cell Exhaustion	High-dose intravenous methotrexate followed by autologous stem cell transplantation as a potentially effective therapy for neurolymphomatosis.	15160344
Fusariosis	Stem Cell Exhaustion	Vesicles as initial skin manifestation of disseminated fusariosis after non-myeloablative stem cell transplantation.	15160931
Mantle cell lymphoma	Stem Cell Exhaustion	A 52-year-old man underwent non-myeloablative stem cell transplantation from his HLA identical sister for the treatment of mantle cell lymphoma.	15160931
Multiple Myeloma	Stem Cell Exhaustion	High-dose topotecan, melphalan and cyclophosphamide (TMC) with stem cell support: a new regimen for the treatment of multiple myeloma.	15160952
Toxic effect, Multiple Myeloma	Stem Cell Exhaustion	The goal of this trial was to assess the toxicity and potential efficacy of high-dose topotecan, melphalan and cyclophosphamide as a preparative regimen for patients with multiple myeloma undergoing autologous stem cell transplantation.	15160952
Medullary Neoplasms, Granulocytic Sarcoma	Stem Cell Exhaustion	Granulocytic sarcomas (GS) are rare extra medullary tumors composed of myeloid progenitor cells.	15160970
Malignant - descriptor, Polycythemia Vera	Stem Cell Exhaustion	Polycythemia vera (PV) is a malignant disorder of hemaopoietic stem cells which is characterized by clonal hyperproliferation and a low rate of apoptosis.	15161531
Specialty Type - cancer	Stem Cell Exhaustion	The established experimental strategy might pave the way for the identification of metastatic stem cells in cancer patients.	15161702
bleb cell extension, Limbal stem cell deficiency	Stem Cell Exhaustion	were treated with an AMT and grouped according to the ophthalmologic diagnosis: Group A, chronic corneal surface defect without limbal stem cell deficiency (n = 8); Group B, conjunctival fornix reconstruction (n = 7); Group C, filtering bleb defect (n = 2).	15162267
Febrile Neutropenia	Stem Cell Exhaustion	Tobramycin pharmacokinetics in children with febrile neutropenia undergoing stem cell transplantation: once-daily versus thrice-daily administration.	15162890
Febrile Neutropenia	Stem Cell Exhaustion	Sixty children (< 18 yrs) with febrile neutropenia undergoing stem cell transplantation.	15162890
Thrombomodulin Alfa, Thrombotic Microangiopathies, Cerebrovascular accident	Stem Cell Exhaustion	Thrombotic microangiopathy (TMA) and stroke due to human herpesvirus-6 (HHV-6) reactivation in an adult receiving high-dose melphalan with autologous peripheral stem cell transplantation.	15164383
Thrombomodulin Alfa, Thrombotic Microangiopathies	Stem Cell Exhaustion	We report an adult autologous stem cell transplant (ASCT) patient who developed transplant-associated thrombotic microangiopathy (TMA) due to human herpesvirus-6 (HHV-6) reactivation.	15164383
Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	The patient improved after treatment, according to the hemophagocytic lymphohistiocytosis protocol (HLH-94) of the Histiocyte Society, with dexamethasone, etoposide, and cyclosporine and unrelated cord blood stem cell transplantation.	15165642
Hemoglobinopathies, beta Thalassemia	Stem Cell Exhaustion	beta-thalassemia major, one of the most prevalent hemoglobinopathies throughout the world, can be cured by allogeneic stem cell transplantation therapy.	15167353
Multiple Myeloma	Stem Cell Exhaustion	Outpatient-based peripheral blood stem cell transplantation for patients with multiple myeloma.	15167908
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	There is a growing demand for autologous stem cell transplantation (ASCT) in newly diagnosed patients with multiple myeloma (MM), resulting in an increasing pressure on available hospital beds.	15167908
Toxic effect, Febrile Neutropenia	Stem Cell Exhaustion	In particular, after conditioning with high-dose melphalan and stem cell infusion, patients were programmed to go home and to be rehospitalized in the case of febrile neutropenia or other severe toxicities.	15167908
Aplastic	Stem Cell Exhaustion	18 (64%) did spend the aplastic phase entirely at home following high-dose chemotherapy and stem cell infusion.	15167908
Multiple Myeloma	Stem Cell Exhaustion	Induction with oral chemotherapy (CID) followed by early autologous stem cell transplantation for de novo multiple myeloma patients.	15167907
Renal Cell Carcinoma Pathway, Refractory Cytopenia of Childhood	Stem Cell Exhaustion	We describe a patient who had received reduced-intensity stem cell transplantation (RIST) for metastatic renal cell carcinoma (RCC).	15167916
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	[Non-myeloablative stem cell transplantation from an HLA identical sibling donor in a case of treatment-related acute myelogenous leukemia].	15168447
Therapy-related myelodysplastic syndrome	Stem Cell Exhaustion	[Early onset invasive pulmonary zygomycosis following allogeneic peripheral blood stem cell transplantation in a patient with therapy-related myelodysplastic syndrome].	15168450
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	A 39-year-old woman received an allogeneic peripheral blood stem cell transplantation from her daughter for secondary myelodysplastic syndrome.	15168450
Multiple Myeloma	Stem Cell Exhaustion	In Keio University Hospital, 44 patients with refractory multiple myeloma, including 18 who had relapsed after hematopoietic stem cell transplantation, were treated with this drug as a single agent.	15168599
Pneumonia in aspergillosis, Chronic granulomatous disease	Stem Cell Exhaustion	An 18-year-old patient with chronic granulomatous disease who had had at least 2 episodes of life-threatening Aspergillus pneumonia was treated with nonmyeloablative allogeneic stem cell transplantation (NSCT) from an HLA-identical and major ABO-incompatible sibling.	15168601
Aplastic Anemia	Stem Cell Exhaustion	Successful non-T-cell-depleted nonmyeloablative hematopoietic stem cell transplantation (NST) from an HLA-haploidentical 2-loci-mismatched sibling in a heavily transfused patient with severe aplastic anemia based on the fetomaternal microchimerism.	15170164
Gastrointestinal mucositis, Communicable Diseases	Stem Cell Exhaustion	We noted a significant decline in the serum concentrations of citrulline of 32 haematopoietic stem cell transplant recipients following intensive myeloablative therapy during the first 3 weeks after transplantation when patients have oral mucositis, a markedly disturbed gut integrity (L/R ratio) and are most at risk of infection and other severe complications.	15170165
Multiple Myeloma	Stem Cell Exhaustion	Clinical outcomes were evaluated in 89 consecutive patients with multiple myeloma that had not responded to dexamethasone-based primary therapy, who received early intensive therapy supported by autologous stem cell transplantation.	15170166
Bone Marrow Diseases, Therapy-Related Acute Myeloid Leukemia	Stem Cell Exhaustion	We report a case of allogeneic stem cell transplantation for therapy-related acute myeloid leukemia in an 8-year-old girl after multimodality treatment for refractory bilateral relapsing RB, with excellent outcome in both the ophthalmic and marrow disease.	15170522
Failure	Stem Cell Exhaustion	c-Kit(W/W) mice can be rescued by wild-type hematopoietic stem cells (HSCs), but it is not known whether the lethality of c-Kit(W/W) mice is the result of HSC failure or defects specific for erythropoiesis.	15178584
Hematologic	Stem Cell Exhaustion	Both AML1 molecules with insertion mutations were non-functional in that they were unable to rescue haematological defects in AML1-deficient mouse embryonic stem cells.	15180860
Multiple Myeloma	Stem Cell Exhaustion	We used the etoposide, methylprednisolone, cytarabine and cisplatin (ESHAP) regimen as second-line therapy in 42 newly diagnosed myeloma patients who had failed vincristine, adriamycin and dexamethasone (VAD)- type therapy (n = 36), responded to first-line treatment but persisted in having significant residual marrow plasmacytosis (n = 5) or failed prior stem cell harvesting (n = 1), with the dual aim of improving disease response and mobilizing peripheral blood stem cells.	15180865
Toxic effect	Stem Cell Exhaustion	We conclude that ESHAP has acceptable toxicity and efficient stem cell mobilizing capability, effectively cytoreduced this chemoresistant group of patients, and did not appear to adversely affect transplant outcome.	15180865
Weight Gain	Stem Cell Exhaustion	These results may suggest that undernutrition affects hematopoiesis as indicated by the reduction of hematopoietic progenitor cells before treatment and the significant increase with weight gain.	15183843
Hidradenitis Suppurativa	Stem Cell Exhaustion	Lipid raft-enriched stem cell-like keratinocytes in the epidermis, hair follicles and sinus tracts in hidradenitis suppurativa.	15186322
leukemia	Stem Cell Exhaustion	CBF is a critical regulator in the generation and differentiation of definitive hematopoietic stem cells and is frequently disrupted in leukemia through chromosome translocations.	15188461
Acute Megakaryocytic Leukemias	Stem Cell Exhaustion	Hematopoietic stem cell transplantation for de novo acute megakaryocytic leukemia in first complete remission: a retrospective study of the European Group for Blood and Marrow Transplantation (EBMT).	15191953
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	CABG and bone marrow stem cell transplantation after myocardial infarction.	15192775
Infarction	Stem Cell Exhaustion	Scintigraphic imaging demonstrated significantly improved local perfusion in the stem cell-treated infarct area.	15192775
Infarction	Stem Cell Exhaustion	Stem cells were isolated from bone marrow using a ferrite-conjugated AC133 antibody, and were injected in the infarct border zone during the CABG operation.	15192775
Sarcoma - category (morphologic abnormality), Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Median survival from reinfusion of stem cells was 74.8 months for patients with myeloma, 47.8 months for patients with malignant lymphoma and 11.7 months for patients with sarcoma.	15195173
Neoplasms	Stem Cell Exhaustion	Hedgehog/smoothened signaling is active in a variety of tumors and is also involved in the maintenance of normal stem cells in vivo.	15196999
Neoplasms	Stem Cell Exhaustion	No adverse effects were noted and normal skin tissue and putative stem cells that were exposed to cyclopamine together with tumors were well preserved under the conditions we describe.	15196999
Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy (HDC) with autologous stem cell transplantation (ASCT) as part of the initial treatment regimen improves progression-free survival (PFS) and overall survival (OS) for patients with multiple myeloma.	15197803
Chronic active Epstein-Barr virus infection	Stem Cell Exhaustion	[Chronic active Epstein-Barr virus infection treated with reduced intensity stem cell transplantation].	15199749
Hepatitis B, Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	[Allogeneic peripheral blood stem cell transplantation for a hepatitis B virus carrier with Epstein-Barr virus associated with hemophagocytic syndrome].	15199750
Communicable Diseases	Stem Cell Exhaustion	Although the origin of the EBV-infected cells could not be determined as being from the host or donor, DLI was a useful treatment for the recurrence of EBV infection after allogeneic stem cell transplantation for EBV-AHS.	15199750
Acute lymphocytic leukemia	Stem Cell Exhaustion	Double allogeneic peripheral blood stem cell transplantation in a 9-year-old patient with relapsed acute lymphoblastic leukemia: case report.	15202165
leukemia	Stem Cell Exhaustion	A 9-year-old female patient with relapsed leukemia that was refractory to conventional reinduction chemotherapy was successfully treated with double allogeneic peripheral blood stem cell transplantation.	15202165
thromboembolic, Paroxysmal nocturnal hemoglobinuria, Hemorrhage, Intravascular hemolysis, Hemoglobinuria	Stem Cell Exhaustion	Paroxysmal nocturnal haemoglobinuria (PNH) is a rare, acquired stem cell disorder, characterised by an abnormal susceptibility of red blood cells to complement induced lysis, resulting in repeated episodes of intravascular haemolysis and haemoglobinuria, thromboembolic events at atypical locations and, to a much lesser extent, bleeding complications.	15203716
Toxic effect	Stem Cell Exhaustion	This study was conducted to define a new maximum tolerated dose and the dose-limiting toxicity (DLT) of melphalan and autologous hematopoietic stem cell transplantation (AHSCT) when used with the cytoprotective agent amifostine.	15205668
Thrombotic Microangiopathies	Stem Cell Exhaustion	Thrombotic microangiopathy after allogeneic stem cell transplantation in the era of reduced-intensity conditioning: The incidence is not reduced.	15205669
Thrombomodulin Alfa, Thrombotic Microangiopathies	Stem Cell Exhaustion	Thrombotic microangiopathy (TMA) is one of the most severe complications of stem cell transplantation (SCT).	15205669
Aspergillosis	Stem Cell Exhaustion	Invasive aspergillosis before allogeneic hematopoietic stem cell transplantation: 10-year experience at a single transplant center.	15205670
Aspergillosis	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HCT) in patients with prior or active invasive aspergillosis (IA) is a frequent consideration.	15205670
Osteoporotic Fractures	Stem Cell Exhaustion	Differential activation of ERK1,2 MAP kinase signaling pathway in mesenchymal stem cell from control and osteoporotic postmenopausal women.	15211572
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation normalizes abnormal bone remodeling and sRANKL/osteoprotegerin ratio in patients with multiple myeloma.	15215875
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Multicenter prospective study of interferon alpha versus allogeneic stem cell transplantation for patients with new diagnoses of chronic myelogenous leukemia.	15218963
Leukemia, Myeloid, Chronic-Phase	Stem Cell Exhaustion	We compared interferon alpha (IFN-alpha) therapy with stem cell transplantation (SCT) for patients with chronic-phase chronic myelogenous leukemia in a multicenter prospective study to investigate the optimal indication and timing of SCT, especially from HLA-matched unrelated donors.	15218963
EBV-Related Burkitt Lymphoma, Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	EBV-positive Burkitt lymphoma as a late-onset posttransplantion lymphoproliferative disorder after allogeneic stem cell transplantation.	15218971
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Posttransplantation lymphoproliferative disorder (PTLD) is one of the well-recognized complications after allogeneic stem cell transplantation (SCT).	15218971
Toxic effect, Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Nonmyeloablative stem cell transplantation in metastatic renal cell carcinoma: delayed graft-versus-tumor effect is associated with chimerism conversion but transplantation has high toxicity.	15220955
Renal Cell Carcinoma Pathway, Refractory Cytopenia of Childhood	Stem Cell Exhaustion	Seven out of 29 patients with metastatic renal cell carcinoma (RCC) considered eligible for allogeneic stem cell transplantation underwent nonmyeloablative stem cell transplantation (NST) from HLA-identical donors.	15220955
Graft-vs-Host Disease	Stem Cell Exhaustion	Tacrolimus instead of cyclosporine used for prophylaxis against graft-versus-host disease improves outcome after hematopoietic stem cell transplantation from unrelated donors, but not from HLA-identical sibling donors: a nationwide survey conducted in Japan.	15220958
Graft-vs-Host Disease, Failure	Stem Cell Exhaustion	Despite recent advances, graft-versus-host disease (GVHD) remains the main cause of treatment failure for patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT).	15220958
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myeloid leukemia (CML) is associated increased stem cell turnover.	15223635
ATRICHIA WITH PAPULAR LESIONS	Stem Cell Exhaustion	These results suggested that CD56 expression was associated with the leukemogenetic mutation at the primitive hematopoietic progenitor cell level and extramedullary relapse in APL patients treated with ATRA and chemotherapy.	15223636
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This report indicates a stem cell origin as previously suggested for Ph+ AML.	15223656
Uveal melanoma	Stem Cell Exhaustion	On the contrary, expression of the stem cell growth factor (c-kit ligand) was detected in all three uveal melanoma cell lines, suggesting the presence of autocrine (paracrine) stimulation pathways.	15223779
Neoplasms	Stem Cell Exhaustion	[High-dose chemotherapy with autologous stem cell rescue in children with high-risk and recurrent brain tumors].	15228928
Neoplasms	Stem Cell Exhaustion	To improve prognosis in patients with high-risk and recurrent tumors, new therapeutic strategies such as high-dose chemotherapy with autologous stem cell rescue (ASCR) have been developed.	15228928
Coronary Arteriosclerosis	Stem Cell Exhaustion	Improvement in endothelial progenitor cells from peripheral blood by ramipril therapy in patients with stable coronary artery disease.	15229388
Coronary Arteriosclerosis	Stem Cell Exhaustion	The aim of this study is to investigate whether angiotensin-converting enzyme inhibitor (ACEI) therapy with ramipril could augment circulating endothelial progenitor cells (EPCs) with enhanced functional activity in patients with stable coronary artery diseases.	15229388
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Impact of cytogenetics on outcome of stem cell transplantation for acute myeloid leukemia in first remission: a large-scale retrospective analysis of data from the Japan Society for Hematopoietic Cell Transplantation.	15239403
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	On the basis of transplantation data from the Japan Society for Hematopoietic Cell Transplantation, we retrospectively analyzed the impact of cytogenetics at diagnosis on the outcome of transplantation in 628 patients with acute myeloid leukemia who underwent autologous (n = 200), allogeneic related (n = 363), or allogenic unrelated (n = 65) stem cell transplantation (SCT) at first complete remission.	15239403
Hematopoietic stem cells, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are clonal haematopoietic stem cell disorders characterised by ineffective and dyspoietic haematopoiesis.	15245507
Multiple Myeloma, Pneumonia, Interstitial	Stem Cell Exhaustion	A rare case of interstitial pneumonitis after tandem high-dose melphalan conditioning and autologous stem cell transplantation in multiple myeloma.	15245515
Malignant Neoplasms, Carcinogenesis	Stem Cell Exhaustion	The most important human malignancies arise from tissues maintained by stem cells, and there is increasing evidence that stem cells are the targets for at least the initial genetic changes that occur during carcinogenesis.	15247012
Neoplasms	Stem Cell Exhaustion	If a subset of stem cells within a niche arises containing an oncogenic mutation, then tumor suppressor mechanisms promote apoptosis of these cells, and the niche restores the original number of stem cells by replication of both normal and mutated stem cells.	15247012
Graft-vs-Host Disease	Stem Cell Exhaustion	Antithymocyte globulin (ATG) is increasingly used in pre-allogeneic stem cell transplantation (allo-SCT) conditioning regimens to prevent graft rejection and graft-versus-host disease.	15247931
Graft-vs-Host Disease, Infection	Stem Cell Exhaustion	A pilot study of targeted itraconazole prophylaxis in patients with graft-versus-host disease at high risk of invasive mould infections following allogeneic stem cell transplantation.	15247932
Systemic Scleroderma	Stem Cell Exhaustion	Autologous stem cell transplantation in the treatment of systemic sclerosis: report from the EBMT/EULAR Registry.	15249325
Systemic Scleroderma, Sample Size Calculation	Stem Cell Exhaustion	To analyse the durability of the responses after haematopoietic stem cell transplantation (HSCT) for severe systemic sclerosis (SSc) and determine whether the high transplant related mortality (TRM) improved with experience.	15249325
Congestive heart failure	Stem Cell Exhaustion	CD34+ and endothelial progenitor cells in patients with various degrees of congestive heart failure.	15249502
Electrocardiogram: myocardial infarction (finding), Vascular System Injuries, Corneal Endothelial Cell Loss	Stem Cell Exhaustion	Peripheral blood CD34(+) cells and circulating endothelial progenitor cells (EPCs) increase in myocardial infarction and vascular injuries as a reflection of endothelial damage.	15249502
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy followed by autologous stem cell transplantation (AT) is accepted as first-line therapy for patients with multiple myeloma (MM), with very good tolerance and low mortality (2-3%).	15249717
Acute leukemia	Stem Cell Exhaustion	Fluconazole is recommended for patients who are to undergo hematopoietic stem cell transplantation; it can be considered for elderly patients with acute leukemia who are to receive intensive chemotherapy.	15250025
Acute myocardial ischemia	Stem Cell Exhaustion	Although preliminary clinical data appear to be promising, the precise pathophysiological role of stem cell mobilization during acute myocardial ischemia remains uncertain.	15253141
Coronary Arteriosclerosis	Stem Cell Exhaustion	The present study was aimed at assessing factors affecting stem cell mobilization after coronary artery bypass grafting used as a clinical model of controlled myocardial ischemia.	15253141
Myocardial Ischemia	Stem Cell Exhaustion	Recently, the role of stem cells as a potential therapeutic tool for ischemic heart disease has been evaluated by a number of experimental and clinical studies.	15253141
Myocardial Ischemia, Acute Coronary Syndrome	Stem Cell Exhaustion	Peripheral concentration of CD34+ stem cells is higher in patients with ischemic heart disease than in healthy controls but it is similar in patients with stable and unstable coronary syndromes.	15253141
Malignant Neoplasms, Breast Diseases	Stem Cell Exhaustion	The aim of the present study was to explore cell biological characteristics of normal breast, benign proliferative breast diseases and noninvasive breast malignancies based on the recently published adult progenitor cell concept from our group.	15254552
Breast Diseases	Stem Cell Exhaustion	Our results provide cell kinetic support to the functional progenitor cell hypothesis, and we propose this concept as an operative model for understanding benign proliferative and malignant breast diseases.	15254552
Breast Diseases	Stem Cell Exhaustion	These findings indicate a significant role of progenitor cells in the development of benign proliferative breast diseases and lend support to the view that malignant transformation in the human breast usually occurs in a cell committed to the glandular lineage.	15254552
Peripheral Stem Cell Transplantation, Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	A 45-year-old patient with extended lymph node metastasis received high-dose EAP with peripheral blood stem cell transplantation (PBSCT), followed by cancer vaccine therapy with dendritic cells (DCs), induced from cryopreserved PBSCs.	15254697
Malignant neoplasm of stomach	Stem Cell Exhaustion	Mobilization of peripheral blood stem cells (PBSCs) after etoposide, adriamycin and cisplatin therapy, and a multimodal cell therapy approach with PBSCs in advanced gastric cancer.	15254697
Malignant neoplasm of stomach	Stem Cell Exhaustion	We examined whether peripheral blood stem cells (PBSCs) could be mobilized during hematopoietic recovery after EAP, and assessed the possibility of using multimodal cell therapy with PBSCs for the treatment of advanced gastric cancer.	15254697
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Feasibility and results of autologous stem cell transplantation in de novo acute myeloid leukemia in patients over 60 years old.	15257930
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The benefits of high-dose cytarabine, anthracyclines and hematopoietic stem cell transplantation in the treatment of acute myeloid leukemia (AML) are greater in younger rather than in older patients.	15257930
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We assessed the proportion of patients over 60 years with de novo AML who qualified for intensive therapy and determined the feasibility and results of autologous stem cell transplantation (ASCT) in first complete remission (CR).	15257930
European Organization for Research and Treatment of Cancer, Lymphoma, Non-Hodgkin, Acute lymphocytic leukemia	Stem Cell Exhaustion	Allogeneic stem cell transplantation in acute lymphoblastic leukemia and non-Hodgkin's lymphoma for patients	15257932
Multiple Myeloma	Stem Cell Exhaustion	First-line therapy with thalidomide and dexamethasone in preparation for autologous stem cell transplantation for multiple myeloma.	15257934
Neoplasms	Stem Cell Exhaustion	Both thalidomide and dexamethasone were administered for 4 months in an attempt to reduce tumor cell mass before collection of peripheral blood stem cells (PBSC) and subsequent double autologous transplantation.	15257934
Multiple Myeloma	Stem Cell Exhaustion	A 50 year-old man was treated for multiple myeloma with a mobilizating chemotherapy prior to autologous stem cell transplantation.	15258512
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Continuous infusion idarubicin and oral busulfan as conditioning for patients with acute myeloid leukemia aged over 60 years undergoing autologous stem cell transplantation.	15258559
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	There is growing interest in autologous stem cell transplantation (ASCT) for elderly patients with acute myeloid leukemia (AML).	15258559
Supraventricular tachyarrhythmia	Stem Cell Exhaustion	Supraventricular tachyarrhythmias after hematopoietic stem cell transplantation: incidence, risk factors and outcomes.	15258562
Tachycardia by ECG Finding	Stem Cell Exhaustion	We have observed clinically significant SVTA in patients undergoing hematopoietic stem cell transplantation occurring at a median of 6 days post transplant, manifesting as atrial fibrillation/flutter or regular narrow-complex tachycardia and persisting for a median of 3 days (range, 0-8).	15258562
melphalan/prednisone protocol	Stem Cell Exhaustion	In a multicenter study, 194 patients were randomized to receive at diagnosis either conventional chemotherapy (6 courses of oral melphalan and prednisone [MP]) or intermediate-dose therapy (2 courses of melphalan at 100 mg/m(2) [MEL100]) with stem cell support.	15265788
Lung Diseases, Obstructive	Stem Cell Exhaustion	[Obstructive lung disease after allogenic stem cell transplantation in children].	15274876
Lung Diseases, Obstructive	Stem Cell Exhaustion	To determine the incidence and clinical progression of obstructive lung disease (OLD) in a population of children who had undergone allogenic hematopoietic stem cell transplantation (HSCT).	15274876
Coronary Restenosis, Atherosclerotic lesion	Stem Cell Exhaustion	c-kit-immunopositive vascular progenitor cells populate human coronary in-stent restenosis but not primary atherosclerotic lesions.	15277195
Blood Vessel	Stem Cell Exhaustion	Moreover, functional endothelial progenitor cells appear to play a protective role in attenuating vascular lesion formation.	15277195
Evans syndrome, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Evans' syndrome following autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma.	15279667
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	A 34-year-old woman with non-Hodgkin's lymphoma received high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation (PBSCT).	15279667
Lymphoma	Stem Cell Exhaustion	Myeloablative allogeneic hematopoietic stem cell transplantation in patients who experience relapse after autologous stem cell transplantation for lymphoma: a report of the International Bone Marrow Transplant Registry.	15280203
Lymphoma, Neoplasms	Stem Cell Exhaustion	Myeloablative allogeneic hematopoietic stem cell transplantation (allo-HSCT) is increasingly used in patients with lymphoma who experience disease relapse after autologous hematopoietic stem cell transplantation (auto-HSCT) because the allograft is tumor free and may induce a graft-versus-tumor effect.	15280203
Secondary Neoplasm	Stem Cell Exhaustion	These findings suggest that the DNA structure linked to the development of metastasis is preordained in progenitor cells relatively early in multistep tumorigenesis.	15280533
Chronic Active EBV Infection of T-and NK-Cell Type, Systemic Form	Stem Cell Exhaustion	Successful control of Epstein-Barr virus (EBV)-infected cells by allogeneic nonmyeloablative stem cell transplantation in a patient with the lethal form of chronic active EBV infection.	15282671
Hematologic Neoplasms, Multiple Organ Failure	Stem Cell Exhaustion	A 17-year-old female with CAEBV, who was refractory to conventional therapies and considered to be unable to receive a myeloablative regimen because of multiple organ dysfunction, underwent allogeneic nonmyeloablative stem cell transplantation (allo-NST) before developing a hematological malignancy.	15282671
Blood Circulation	Stem Cell Exhaustion	Furthermore, EC progenitor cells (EPCs), derived from the bone marrow and circulating in the bloodstream, can differentiate into ECs.	15284068
Graft-vs-Host Disease	Stem Cell Exhaustion	Mycophenolate mofetil and cyclosporine for graft-versus-host disease prophylaxis following reduced intensity conditioning allogeneic stem cell transplantation.	15286687
Toxic effect	Stem Cell Exhaustion	The use of reduced intensity conditioning (RIC) regimens for allogeneic stem cell transplantation (allo-SCT) can result in a significant decrease in early procedure-related toxicity in patients not eligible for standard myeloablative regimens.	15286687
Multiple Myeloma	Stem Cell Exhaustion	Single agent dexamethasone for pre-stem cell transplant induction therapy for multiple myeloma.	15286691
Neoplasms	Stem Cell Exhaustion	For those undergoing HDT, initial therapy aimed at reducing tumor burden is given prior to stem cell harvest.	15286691
Iron Overload, Aspergillosis	Stem Cell Exhaustion	Frequent severe liver iron overload after stem cell transplantation and its possible association with invasive aspergillosis.	15286693
herpesvirus 6, human, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	[Successful treatment with antiviral agents for human herpesvirus type 6 encephalitis following reduced intensity stem cell transplantation in a patient with myelodysplastic syndrome].	15287524
Encephalitis	Stem Cell Exhaustion	We report here a patient who suffered from PCR-confirmed human herpesvirus type 6 (HHV-6) encephalitis following reduced intensity stem cell transplantation (RIST) from her HLA-matched sibling donor.	15287524
Neurologic Symptoms	Stem Cell Exhaustion	This case shows that HHV-6 infection has to be considered in patients with neurological symptoms following stem cell transplantation, and suggests the necessity of PCR for HHV-6 virus from the CSF.	15287524
Brugada Syndrome Ventricular Arrhythmia by ECG Finding, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	[Brugada syndrome occurring after autologous peripheral blood stem cell transplantation for acute myeloid leukemia].	15287526
Brugada Syndrome Ventricular Arrhythmia by ECG Finding, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 74-year-old male was found to be suffering from the Brugada syndrome after undergoing high dose chemotherapy followed by autologous peripheral blood stem cell transplantation (ABSCT) for acute myeloid leukemia.	15287526
Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy and autologous peripheral blood stem cell transplantation in high-risk multiple myeloma.	15287913
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We compared the effect of high-dose therapy together with autologous peripheral blood stem cell transplantation (autoPBSCT) in 60 patients with multiple myeloma (MM) with 90 patients who underwent conventional chemotherapy.	15287913
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	To evaluate ICE (ifosfamide, carboplatin, etoposide) as second-line chemotherapy in relapsed or primary progressive aggressive lymphoma, in terms of objective response rate (ORR) and peripheral blood stem cell (PBSC) harvest mobilization rate.	15287915
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Although the number of patients analysed was relatively small, the present data suggest that, in MDS patients, response to rHuEpo and G-CSF may be related to the proliferation of karyotypically normal but potentially defective CD34(+) progenitor cells.	15287942
Corneal dystrophy	Stem Cell Exhaustion	Penetrating limbo-keratoplasty for granular and lattice corneal dystrophy: survival of donor limbal stem cells and intermediate-term clinical results.	15288983
Childhood Breast Carcinoma	Stem Cell Exhaustion	Prognostic analysis of early lymphocyte recovery in patients with advanced breast cancer receiving high-dose chemotherapy with an autologous hematopoietic progenitor cell transplant.	15297410
Childhood Breast Carcinoma	Stem Cell Exhaustion	The purpose of this study was to evaluate the prognostic effect of early posttransplant lymphocyte recovery in patients with advanced breast cancer receiving high-dose chemotherapy with autologous hematopoietic progenitor cell transplantation.	15297410
Childhood Breast Carcinoma	Stem Cell Exhaustion	Early lymphocyte recovery is an independent outcome predictor in metastatic breast cancer patients receiving high-dose chemotherapy and an autologous peripheral blood progenitor cell transplant.	15297410
Childhood Breast Carcinoma	Stem Cell Exhaustion	The prognostic effect of absolute lymphocyte count in metastatic breast cancer was restricted to those patients receiving unmanipulated peripheral blood progenitor cells (P = 0.04).	15297410
Fracture	Stem Cell Exhaustion	In conclusion, the data indicate that individual variations in cell number, cell morphology and in the osteogenic potential of progenitor cells of the patient may be relevant for a successful treatment of bone fractures in the elderly by cell-based therapy approaches.	15297780
Lymphoproliferative Disorders	Stem Cell Exhaustion	Combined administration of alpha-erythropoietin and filgrastim can improve the outcome and cost balance of autologous stem cell transplantation in patients with lymphoproliferative disorders.	15300235
Lymphoma, Non-Hodgkin, Familial, Medial collateral ligament, Mantle cell lymphoma, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	We report the outcomes after reduced-intensity conditioning allogeneic stem cell transplantation (RIT) for non-Hodgkin lymphoma (NHL) in 88 patients (low-grade NHL [LG-NHL], n = 41; high-grade NHL [HG-NHL], n = 37; mantle cell lymphoma [MCL], n = 10).	15304395
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML.	15306667
Blast Phase, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The progression of chronic myelogenous leukemia (CML) to blast crisis is supported by self-renewing leukemic stem cells.	15306667
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We investigated whether leukemic stem cells in CML also use the beta-catenin pathway for self-renewal.	15306667
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We used fluorescence-activated cell sorting to isolate hematopoietic stem cells, common myeloid progenitors, granulocyte-macrophage progenitors, and megakaryocyte-erythroid progenitors from marrow during several phases of CML and from normal marrow.	15306667
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	BCR-ABL, beta-catenin, and LEF-1 transcripts were compared by means of a quantitative reverse-transcriptase-polymerase-chain-reaction assay in normal and CML hematopoietic stem cells and granulocyte-macrophage progenitors.	15306667
Burn injury	Stem Cell Exhaustion	[Long-term results of homologous penetrating limbokeratoplasty in total limbal stem cell insufficiency after chemical/thermal burns].	15309485
Burn injury	Stem Cell Exhaustion	Since 1991 homologous penetrating limbokeratoplasty has been performed in 32 patients with severe limbal stem cell insufficiency following chemical/thermal burns.	15309485
Thrombosis	Stem Cell Exhaustion	Apheresis catheters have simplified collection of peripheral blood stem cells (PBSC), but may be associated with thrombosis of the instrumented vessels.	15319243
Aspergillosis	Stem Cell Exhaustion	Incidence of invasive aspergillosis after allogeneic hematopoietic stem cell transplantation with a reduced-intensity regimen compared with transplantation with a conventional regimen.	15319776
Aspergillosis	Stem Cell Exhaustion	To evaluate the clinical characteristics of invasive aspergillosis (IA) after reduced-intensity stem cell transplantation (RIST) compared with those after conventional stem cell transplantation (CST), we examined the medical records of 486 CST and 178 RIST recipients.	15319776
Central neuroblastoma	Stem Cell Exhaustion	[Treatment of high-risk neuroblastoma with intensive chemotherapy, autologous peripheral blood stem cell transplantation, and 13-cis-retinoic acid].	15324562
Central neuroblastoma	Stem Cell Exhaustion	This study aimed to investigate if very high dose chemotherapy in conjunction with autologous peripheral blood stem cell transplantation and 13-cis-retinoic acid could get excellent results in children with high risk neuroblastoma.	15324562
Central neuroblastoma	Stem Cell Exhaustion	The new strategies focused on very high dose chemotherapy, autologous peripheral blood stem cell transplantation and biological therapy might be a good option for patients with advance neuroblastoma.	15324562
Lymphoma	Stem Cell Exhaustion	The lymphoma was refractory to cyclophosphamide-doxorubicin-vincristine-prednisolone (CHOP); this was followed by intensive chemotherapy and autologous stem-cell transplantation, resulting finally in a complete remission.	15326651
Hematological Disease	Stem Cell Exhaustion	Patients with seriously decreased cardiac function due to chemotherapeutic drugs cannot usually receive allogeneic hematopoietic stem cell transplantation (SCT) for hematologic disorders.	15329467
malignant disease, Myeloproliferative disease, Lymphoma, Mastocytosis, Gastrointestinal Stromal Tumors, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Mutations of the stem cell factor receptor C-KIT play a major pathogenetic role in the development of different malignant diseases like human mastocytosis, myeloproliferative disorders, gastrointestinal stromal tumors, acute myelogenous leukemia, and sinonasal lymphomas.	15330987
Fanconi Anemia	Stem Cell Exhaustion	Hematopoietic stem cell transplant (SCT) is currently the only therapy that can restore normal hematopoiesis in patients with Fanconi anemia (FA).	15331448
Non-Small Cell Lung Carcinoma, Neoplasms	Stem Cell Exhaustion	CD133 positive endothelial progenitor cells contribute to the tumour vasculature in non-small cell lung cancer.	15333659
Neoplasms	Stem Cell Exhaustion	Recent results generated in a mouse model suggest that tumour angiogenesis/vasculogenesis can be initiated and maintained by bone marrow derived endothelial progenitor cells.	15333659
Non-Small Cell Lung Carcinoma, Neoplasms	Stem Cell Exhaustion	This present study investigated the distribution and frequency of CD133 positive endothelial progenitor cells in patients with non-small cell lung cancer (NSCLC) (tumour tissue and tumour free lung regions) and healthy controls using fresh frozen specimens.	15333659
Non-Small Cell Lung Carcinoma, Neoplasms	Stem Cell Exhaustion	A significant increase in CD133 positive cells was documented in patients with NSCLC, suggesting an involvement of endothelial progenitor cells in tumour vasculogenesis and tumour growth in these patients.	15333659
Lymphoma	Stem Cell Exhaustion	We have undertaken a retrospective sequential-cohort analysis of 131 lymphoma patients treated with the BEAM regimen and autologous stem cell transplantation, to compare BEAM at standard doses (sBEAM; n = 67 from May 1990 to April 1995) and BEAM with escalated etoposide dose from 800 to 1600 mg/m(2) (eBEAM; n = 64 from May 1995 to June 1999).	15334049
Rheumatoid Arthritis	Stem Cell Exhaustion	This report describes the first allogeneic hematopoietic stem cell transplantation (HSCT) performed for the indication of rheumatoid arthritis (RA).	15334459
Gammopathy, Multiple Myeloma, Chromosome Aberrations	Stem Cell Exhaustion	MDS/AML-associated cytogenetic abnormalities in multiple myeloma and monoclonal gammopathy of undetermined significance: evidence for frequent de novo occurrence and multipotent stem cell involvement of del(20q).	15334545
Monoclonal Gammopathy of Undetermined Significance	Stem Cell Exhaustion	In one MGUS with del(20q), fluorescence in situ hybridization analyses revealed its presence in CD34+CD38- (hematopoietic stem cells), CD34+CD38+ (progenitors), CD19+ (B cells), and CD15+ (myeloid cells).	15334545
Failure	Stem Cell Exhaustion	We believe that there is a unique failure of the damaged myocardium to provide the appropriate molecular signals for stem cells engraftment related to age.	15334766
Multiple Myeloma	Stem Cell Exhaustion	In addition to myeloma markers, the cells were positive for B cell-associated, myeloid and stem cell markers.	15335187
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Treatment of primary acute myeloid leukemia: results of a prospective multicenter trial including high-dose cytarabine or stem cell transplantation as post-remission strategy.	15339677
Multiple Myeloma	Stem Cell Exhaustion	p53 gene deletion detected by fluorescence in situ hybridization is an adverse prognostic factor for patients with multiple myeloma following autologous stem cell transplantation.	15339849
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We investigated the relevance of p53 deletions to the clinical outcome of patients with multiple myeloma (MM) treated with high-dose chemotherapy and autologous stem cell transplantation.	15339849
Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	She also received adjuvant treatment with peripheral blood stem cell transplantation (PBSCT).	15340820
Prostate carcinoma, Carcinogenesis	Stem Cell Exhaustion	Prostate stem cell antigen (PSCA) expression in human prostate cancer tissues: implications for prostate carcinogenesis and progression of prostate cancer.	15342669
Aplastic Anemia	Stem Cell Exhaustion	Immune-mediated destruction of hematopoietic stem and progenitor cells is pathophysiologic in most cases of aplastic anemia (AA).	15345281
Dysplasia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The AC133+ hematopoietic stem cell-like fractions were purified from the bone marrow of individuals with de novo AML without dysplasia (n = 15), AML-MLD (n = 11), MDS-related AML (n = 11), or TRL (n = 2), and were subjected to the synthesis of cRNA which was subsequently hybridized to microarray harboring oligonucleotide corresponding to more than 12,000 probe sets.	15345284
Tissue damage	Stem Cell Exhaustion	Endothelial progenitor cell (EPC) mobilization has been reported following tissue damage, whereas no data are available regarding the mobilization of hematopoietic progenitor cells (HPCs).	15345590
Acute myocardial infarction	Stem Cell Exhaustion	Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarction.	15345590
Angina Pectoris, Acute myocardial infarction	Stem Cell Exhaustion	We performed the phenotypic and functional analysis of circulating CD34+ progenitor cells in patients with acute myocardial infarction (AMI), assessed from admission up to 60 days, in patients with stable angina pectoris (SA), and in healthy controls (CTRLs).	15345590
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The purpose of this prospective cohort study was to identify pretransplant and transplant predictors of 1-year survival after allogeneic hematopoietic stem cell transplantation (HSCT) for chronic myelogenous leukemia.	15345782
Cardiotoxicity	Stem Cell Exhaustion	After cumulative doses of DOX 600 mg/sqm and 700 mg/sqm these patients survived 12 months in their 2nd CR without significant signs of cardiotoxicity, even after their successful autologous peripheral stem cells transplantation.	15346637
Multiple Myeloma	Stem Cell Exhaustion	Relation between harvest success and outcome after autologous peripheral blood stem cell transplantation in multiple myeloma.	15347313
Multiple Myeloma	Stem Cell Exhaustion	We studied the prognostic influence of pretransplant characteristics on response and survival in 104 consecutive patients with multiple myeloma receiving uniform pretransplant treatment consisting of VAD regimen, stem cell mobilisation, harvesting, and conditioning with melphalan 200 mg/m2.	15347313
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is a stem cell disorder characterized by ineffective haematopoiesis and blood cytopenias.	15352984
Specialty Type - cancer	Stem Cell Exhaustion	Prospective clinical evaluation of lower cut-offs for galactomannan detection in adult neutropenic cancer patients and haematological stem cell transplant recipients.	15352990
Juvenile Myelomonocytic Leukemia	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) in children with juvenile myelomonocytic leukemia (JMML): results of the EWOG-MDS/EBMT trial.	15353481
Juvenile Myelomonocytic Leukemia	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HSCT) is the only proven curative therapy for juvenile myelomonocytic leukemia (JMML).	15353481
NF1 gene	Stem Cell Exhaustion	Concentrations of midkine (MK) and stem cell factor, but not epidermal growth factor, were substantially increased in serum of NF1 patients when compared with healthy controls.	15355893
NF1 gene	Stem Cell Exhaustion	Stem cell factor and MK concentrations above a defined threshold in serum of NF1 patients are of diagnostic benefit for 96% of patients in the cohort tested.	15355893
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Recent data suggest that STI571 (Imatinib) induces complete cytogenetic responses in patients with chronic myeloid leukemia (CML) who relapse after allogeneic stem cell transplantation (SCT).	15359647
Multiple Myeloma	Stem Cell Exhaustion	[Autologous peripheral blood stem cell transplantation for Japanese multiple myeloma patients: results of a feasibility study].	15359911
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	A feasibility study on high-dose therapy with autologous peripheral blood stem cell transplantation (HDT/PBSCT) was performed in Japanese patients with multiple myeloma (MM).	15359911
Lymphoma, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	We have previously demonstrated that when cultured in Dexter-type Long-Term Marrow Cultures (LTMC), hematopoietic progenitor cells (HPC) from patients with Diffuse Large B-Cell Lymphoma (DLBCL) show a defective proliferation, as compared to HPC from normal marrow.	15360008
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Although the reason for these observations is not clear, our results suggest the possibility that primitive CD34+ progenitor cells present in bone marrow, which show deficient proliferation and expansion potentials in vitro, are involved in the origin/progression of DLBCL.	15360008
Neoplasms	Stem Cell Exhaustion	The pattern of immunoglobulin heavy chain (IgH) gene rearrangement in the patients' bone marrow aspirate and brain tumor was identical and suggested that both tumors originated from the same B-cell progenitors.	15360010
PAFAH1B1 wt Allele, TRPV6 wt Allele, Leukemia, T-Cell, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	With the recent progress in reduced-intensity conditioning stem cell transplantation (RIST) and taking into consideration the concept of feto-maternal immunological tolerance, we carried out non-T-cell depleted HLA haploidentical RIST from noninherited maternal antigen (NIMA) complementary siblings or offspring donors for four older patients: a patient with myeloplastic syndrome (MDS) and three patients with adult T-cell leukemia (ATL) in partial remission or with progressive disease.	15361902
Communicable Diseases	Stem Cell Exhaustion	Fusarium dimerum infection in a stem cell transplant recipient treated successfully with voriconazole.	15361915
Aplastic Anemia, Infectious Lung Disorder, Communicable Diseases	Stem Cell Exhaustion	We present the case of a 19-year-old female diagnosed with a proven F. dimerum soft-tissue infection of the foot and possible pulmonary infection with the same organism 10 days following a sibling allogeneic stem cell transplant for severe aplastic anaemia.	15361915
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We conclude that t(6;9)-positive AML cases have distinctive morphologic features, an immunophenotype suggesting origin from an early hematopoietic progenitor cell, and a high frequency of flt3 gene mutations.	15362364
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Autologous hematopoietic stem-cell transplantation for children with acute myeloid leukemia in first or second complete remission: a prognostic factor analysis.	15365077
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	To determine prognostic factors correlated with outcomes after autologous hematopoietic stem-cell transplantation (HSCT) in children with acute myeloid leukemia (AML).	15365077
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Autologous stem-cell transplantation in diffuse large B-cell non-Hodgkin's lymphoma not achieving complete response after induction chemotherapy: the GEL/TAMO experience.	15367411
Decreased platelet count, Acute leukemia	Stem Cell Exhaustion	We performed a prospective, randomized, open, blinded end point (PROBE) study to assess the efficiency of transfusing high doses of platelets in patients with thrombocytopenia, either acute leukemia (AL) or those undergoing autologous hematopoietic stem cell transplantation (AT).	15367427
Teratoma	Stem Cell Exhaustion	These results assume that HIMT cells, which were derived from an immature teratoma, have progenitor and/or stem cells which can differentiate into nerve and/or glial cells.	15369138
Neoplasms	Stem Cell Exhaustion	High-dose chemotherapy with autologous stem cell support reduced the tumor burden and led to a symptom-free interval of 6 months.	15369185
Aggressive course	Stem Cell Exhaustion	Our results demonstrate that treatment with IEV regimen is effective in refractory or relapsing aggressive NHL, resulting in a high percentage of successful stem cell mobilization and feasibility of ASCT.	15370212
Eosinophilic Fasciitis	Stem Cell Exhaustion	Eosinophilic fasciitis after allogeneic stem cell transplantation: a case report and review of the literature.	15370231
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We present a 35-year-old male with acute myeloblastic leukemia who underwent allogeneic stem cell transplantation (AlloSCT) from his sibling.	15370231
Trauma, Corneal stromal opacities, Low Vision	Stem Cell Exhaustion	Ocular trauma or disease may lead to severe corneal opacification and, consequently, severe loss of vision as a result of complete loss of corneal epithelial stem cells.	15371576
Allogeneic Hematopoietic Stem Cell Transplantation, Colon Carcinoma Metastatic in the Liver	Stem Cell Exhaustion	Indium-111-labelled donor-lymphocyte infusion by way of hepatic artery and radio-frequency ablation against liver metastases of renal and colon carcinoma after allogeneic hematopoietic stem-cell transplantation.	15371671
Specialty Type - cancer	Stem Cell Exhaustion	In patients with metastatic solid cancer, antitumor effects occur after allogeneic stem-cell transplantation (SCT).	15371671
Lymphoproliferative disease virus	Stem Cell Exhaustion	Treatment of Epstein-Barr virus lymphoproliferative disease after hematopoietic stem-cell transplantation with hydroxyurea and cytotoxic T-cell lymphocytes.	15371682
RAPH1 gene, Lymphoproliferative Disorders	Stem Cell Exhaustion	Epstein-Barr virus (EBV) lymphoproliferative disease (LPD) is a potentially fatal complication that may follow allogeneic hematopoietic stem-cell transplantation (HSCT).	15371682
Acute leukemia	Stem Cell Exhaustion	The occurrence of oral penicillin-resistant viridans group streptococci (VGS) was studied in 50 patients with either newly diagnosed acute leukaemia or autologous peripheral stem cell transplants.	15373884
Cervical Intraepithelial Neoplasia, Aneuploidy	Stem Cell Exhaustion	Using in vitro mouse embryonic stem cells, APC mutations have been proposed to dysregulate the interactions between kinetochores and microtubules during mitosis, leading to chromosomal instability (CIN) and aneuploidy.	15376262
Multiple Myeloma	Stem Cell Exhaustion	Standard treatment for patients with multiple myeloma is debulking chemotherapy with non-alkylating agents followed by a regimen to mobilize peripheral blood stem cells (PBSC) and the transplantation of the mobilized, autologous PBSC.	15377474
Fatigue, Depression, CTCAE, Lymphoma	Stem Cell Exhaustion	Fatigue and depression in patients with lymphoma undergoing autologous peripheral blood stem cell transplantation.	15378094
Fatigue, Depression, CTCAE, Lymphoma	Stem Cell Exhaustion	To describe the patterns of depression and fatigue, including its dimensions, and the relationship between these two variables in patients with lymphoma undergoing autologous peripheral blood stem cell transplantation (PBSCT).	15378094
Type II Mucolipidosis, B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1	Stem Cell Exhaustion	Lineage switch and multilineage involvement in two cases of pH chromosome-positive acute leukemia: evidence for a stem cell disease.	15378954
B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1	Stem Cell Exhaustion	Philadelphia chromosome-positive acute leukemias (Ph+ AL) show variable cytologic features, possibly reflecting heterogeneous stem cell involvement.	15378954
Blast Phase	Stem Cell Exhaustion	These findings show that biologically Ph+ AL may resemble chronic myelogenous leukemia blast crisis, since it may originate from an undifferentiated stem cell carrying the t(9;22) translocation.	15378954
Neoplasms	Stem Cell Exhaustion	Frequent activation of transcription of the gene PRAME in MM, its assay can be used for monitoring of the disease course, assessment of remission completeness, detection of tumor cell contamination of preparations of autologous stem cells of peripheral blood.	15379133
Chronic myeloproliferative disorder, Hematopoietic stem cells	Stem Cell Exhaustion	Philadelphia chromosome negative chronic myeloproliferative disorders (Ph- CMPD) comprise haematopoietic stem cell disorders with currently unknown underlying molecular defect.	15380337
MYELODYSPLASTIC SYNDROME, Chromosome Aberrations	Stem Cell Exhaustion	Analysis of hematopoietic progenitor cells in patients with myelodysplastic syndromes according to their cytogenetic abnormalities.	15380343
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome, Chromosome Aberrations	Stem Cell Exhaustion	The present work analyzes the hematopoietic progenitor cells (HPC) in myelodysplastic syndrome (MDS) patients using both an immunophenotypical and a functional approaches in order to know whether they are similar in patients with or without cytogenetic abnormalities.	15380343
Specialty Type - cancer	Stem Cell Exhaustion	Reserve-stem cells, the permanent cells of body tissues, are thought to be the progenitor cells of cancer.	15380388
Specialty Type - cancer	Stem Cell Exhaustion	Here, we show some histopathological observations suggesting that an anti-cancer mechanism might be associated to reserve/stem cells and that it could be responsible for huge differences in cancer incidence between closely related body sites.	15380388
AIDS-Related Hodgkin Lymphoma	Stem Cell Exhaustion	Durable remissions with autologous stem cell transplantation for high-risk HIV-associated lymphomas.	15388574
Lymphoma, Non-Hodgkin, Familial, Hodgkin Disease, HD Term Type, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	In the non-HIV setting, patients with relapsed Hodgkin disease (HD) or non-Hodgkin lymphoma (NHL) have a better chance of long-term remission with high-dose chemotherapy with autologous stem cell rescue (ASCT) compared with conventional salvage chemotherapy.	15388574
Chronic graft-versus-host disease, Multiple Myeloma	Stem Cell Exhaustion	Relapse to prior autograft and chronic graft-versus-host disease are the strongest prognostic factors for outcome of melphalan/fludarabine-based dose-reduced allogeneic stem cell transplantation in patients with multiple myeloma.	15389436
Multiple Myeloma	Stem Cell Exhaustion	From 1998 to 2002, 120 patients with multiple myeloma were treated with melphalan/fludarabine followed by allogeneic stem cell transplantation.	15389436
Megakaryoblasts, Acute leukemia	Stem Cell Exhaustion	Transformation of ET into erythroleukemia may demonstrate the pluripotent potential of the neoplastic hemopoietic stem cell, with the ability to cause acute leukemia not only of myeloid or megakaryoblastic but also of erythroid lineage.	15389906
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	We present the case of a 9-year-old Latin-American boy who was referred for stem cell transplantation because of recurrent acute lymphoblastic leukemia (ALL).	15390181
Neoplasms	Stem Cell Exhaustion	The purpose of this study was to investigate the incidence and prognostic relevance of tumor cell detection in granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cell collections (PBPCCs) using cytokeratin (CK), maspin (MAS), and mammaglobin (MAM) genes as epithelial cell markers.	15447988
Plasmodium falciparum, Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	Plasmodium falciparum causing hemophagocytic syndrome after allogeneic blood stem cell transplantation.	15448674
Plasmodium falciparum infection, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We describe a case of Plasmodium falciparum infection in a 25-year-old male patient with a myelodysplastic syndrome, who underwent allogeneic peripheral blood stem cell transplantation (PBSCT) in September 2003.	15448674
Specialty Type - cancer	Stem Cell Exhaustion	In this study, the authors investigated the factorial validity of the PCL with data from 236 cancer survivors who received a bone marrow or stem cell transplantation.	15456381
Hematologic Neoplasms	Stem Cell Exhaustion	In a prospective inpatient study conducted from July 1994 to August 1997, 220 patients aged 16-65 years received hematopoietic stem cell transplantation (SCT) for hematologic cancer at a single institution.	15465077
Peripheral Arterial Diseases	Stem Cell Exhaustion	We investigated efficacy and safety of implantation of autologous bone marrow mononuclear cells plus platelets, including endothelial progenitor cells (EPCs), for recovering refractory chronic peripheral arterial disease (PAD) using visual and quantitative analyses by 99mTc-tetrofosmin (TF) perfusion scintigraphy, and also investigated various quantitative assessments objectively.	15468685
Disease	Stem Cell Exhaustion	Because adipocytes have been demonstrated to produce numerous cytokines and peptide hormones, we investigated the expression of SRIF and its receptors (SSTR1-5) in human adipose tissue after inflammatory stimulation in vitro and in tissues from patients with septic disease.Preadipocyte-derived adipocytes, mesenchymal stem cell-derived adipocytes, and mature explanted adipocytes expressed SRIF-mRNA after endotoxin [lipopolysaccharide (LPS)] or IL-1beta treatments.	15472172
Blood Circulation	Stem Cell Exhaustion	Bacterial and fungal bloodstream isolates from 796 hematopoietic stem cell transplant recipients between 1991 and 2000.	15480665
Blood Circulation, Behavioral Symptoms Index Composite Score (BASC-2)	Stem Cell Exhaustion	To examine shifts in the etiology, incidence, evolution, susceptibility, and patient mortality of bacterial and fungal bloodstream isolates (BSIs) from hematopoietic stem cell transplantation (HSCT) recipients, we reviewed the BSIs of 796 patients who underwent an HSCT in our institution during a 10-year period.	15480665
Multiple Myeloma	Stem Cell Exhaustion	Administration of recombinant human erythropoietin alpha before autologous stem cell transplantation reduces transfusion requirement in multiple myeloma patients.	15480819
Anemia	Stem Cell Exhaustion	Recombinant human erythropoietin administered after peripheral blood stem cell transplantation (PBSCT) has been ineffective for the treatment of anemia.	15480819
Aplastic	Stem Cell Exhaustion	We administered recombinant human erythropoietin alpha (rHuEPO) prior to high-dose therapy after peripheral blood stem cell (PBSC) collection to evaluate its efficacy on transfusion requirements and hematological parameters during the post-transplant aplastic phase.	15480819
Cytomegalovirus Infections, leukemia	Stem Cell Exhaustion	The findings in this case suggest that stem cell transplantation for a leukemia patient with CMV disease may be effective.	15481451
Hypertransaminasaemia	Stem Cell Exhaustion	He suffered two episodes of transient transaminitis of unknown origin after successive autologous stem cell transplantations.	15481613
Renal dysfunction	Stem Cell Exhaustion	The combination chemotherapy followed by autologous stem cell transplantation led to a partial resolution of her renal dysfunction, continued by a slight reduction in the number of crystalline-containing podocytes at the second renal biopsy.	15481856
leukemia	Stem Cell Exhaustion	Hematopoietic stem cell transplantation among patients with leukemia of all ages in Texas.	15484218
Cholangiocarcinoma	Stem Cell Exhaustion	Possible stem cell origin of human cholangiocarcinoma.	15484322
Cholangiocarcinoma	Stem Cell Exhaustion	To investigate the expression of CD34 and c-kit (receptor of stem cell factor) in cholangiocarcinoma.	15484322
Cholangiocarcinoma	Stem Cell Exhaustion	The expression of c-kit by some cholangiocarcinoma cells suggests that cholangiocarcinoma might originate from liver stem cells.	15484322
Medulloblastoma	Stem Cell Exhaustion	Expression of MATH1, a marker of cerebellar granule cell progenitors, identifies different medulloblastoma sub-types.	15488319
Coronary Arteriosclerosis	Stem Cell Exhaustion	Intracoronary progenitor cell application did not incur any measurable ischemic myocardial damage, but one patient experienced distal embolization before cell therapy.	15489105
Acute myocardial infarction	Stem Cell Exhaustion	Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final one-year results of the TOPCARE-AMI Trial.	15489105
Electrocardiogram: myocardial infarction (finding), "cytidylyl-(3-5)-cytidine", Acute myocardial infarction	Stem Cell Exhaustion	The Transplantation of Progenitor Cells And Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI) trial investigates both safety, feasibility, and potential effects on parameters of myocardial function of intracoronary infusion of either circulating progenitor cells (CPC) or bone marrow-derived progenitor cells (BMC) in patients with acute myocardial infarction (AMI).	15489105
cytidylyl-(3-5)-cytidine	Stem Cell Exhaustion	Intracoronary infusion of progenitor cells (either BMC or CPC) is safe and feasible in patients after AMI successfully revascularized by stent implantation.	15489105
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Allogeneic bone marrow or stem cell transplantation is a curative therapeutic option for chronic myelogenous leukemia.	15489879
Endocarditis	Stem Cell Exhaustion	Characteristics and outcome of patients developing endocarditis following hematopoietic stem cell transplantation.	15489882
Endocarditis	Stem Cell Exhaustion	Endocarditis is an uncommon complication of hematopoietic stem cell transplantation (HSCT).	15489882
Endocarditis	Stem Cell Exhaustion	In all, 20 cases of endocarditis were identified (1.3% of all patients) with nine patients having received cryopreserved autologous stem cells, six stem cells from a histocompatible sibling and five patients stem cells from an unrelated donor.	15489882
Neoplasms	Stem Cell Exhaustion	The finding of another GP occurring outside the periampullary region bolsters the argument for a stem cell origin of this unusual tumor.	15492999
Chronic myeloproliferative disorder, Polycythemia Vera, Thrombocythemia, Essential	Stem Cell Exhaustion	Essential thrombocythemia (ET) and polycythemia vera (PV) are chronic myeloproliferative disorders that share the involvement of a multipotent progenitor cell and dominance of the transformed clone over normal hematopoiesis.	15494424
Influenza	Stem Cell Exhaustion	Influenza infections after hematopoietic stem cell transplantation: risk factors, mortality, and the effect of antiviral therapy.	15494906
Myeloproliferative disease	Stem Cell Exhaustion	A 46-year-old man with myeloproliferative disorder received a stem cell transplant from an HLA-identical unrelated donor.	15497526
Abdominal Pain	Stem Cell Exhaustion	Severe abdominal pain is one of the most important signs of VZV infection for recipients of stem cell transplantation.	15497526
Acute myocardial infarction	Stem Cell Exhaustion	Improvement of cardiac function after transplantation of autologous bone marrow mesenchymal stem cells in patients with acute myocardial infarction.	15498362
IgD myeloma, Multiple Myeloma	Stem Cell Exhaustion	The characteristics and outcomes of 25 patients with IgD myeloma (2.6% of all myeloma patients), including 11 patients treated with autologous stem cell transplantation (ASCT) are reported.	15503021
Hematologic Neoplasms	Stem Cell Exhaustion	Unrelated donor hematopoietic stem cell transplantation for patients with hematologic malignancies using a nonmyeloablative conditioning regimen of fludarabine, low-dose total body irradiation, and rabbit antithymocyte globulin.	15505609
Disease, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are clonal stem cell disorders, characterized by ineffective and dysplastic hematopoiesis.	15507396
Intravascular hemolysis, Hemoglobinuria, Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	Paroxysmal nocturnal haemoglobinuria (PNH) is a rare, acquired stem-cell disorder characterized by defective haematopoiesis, which results in an increased sensitivity of the erythrocytes to complement-mediated intravascular haemolysis.	15507422
Anemia, Chronic disease	Stem Cell Exhaustion	Decreased hemoglobin is often anemia of chronic disease and may be due to the effects of inflammatory cytokines on erythroid progenitor cells.	15509883
Tracheobronchitis due to Aspergillus, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	[Acute myeloid leukemia with Aspergillus tracheobronchitis after allogeneic peripheral blood stem cell transplant].	15510828
Tracheobronchitis due to Aspergillus, Aspergillosis	Stem Cell Exhaustion	The clinical course of Aspergillus tracheobronchitis in allogeneic stem cell transplant recipients is, however, different from that of the usual invasive Aspergillus infection, and although Aspergillus tracheobronchitis is a very rare disease, attention should be paid to the possibility of its occurrence.	15510828
Toxic effect, Lymphoma	Stem Cell Exhaustion	High dose chemotherapy with thiotepa, mitoxantrone and carboplatin (TMJ) followed by autologous stem cell support in 100 consecutive lymphoma patients in a single centre: analysis of efficacy, toxicity and prognostic factors.	15512814
Lymphoma, Non-Hodgkin, Familial, Hodgkin Disease, HD Term Type, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	High dose chemotherapy with autologous stem cell transplant is often used in patients with Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL) who either do not respond to, or relapse after conventional chemotherapy.	15512814
Lymphoma, Non-Hodgkin, Familial, HD Term Type	Stem Cell Exhaustion	In this study, we analyzed the results of 100 consecutive patients with HD and NHL who met our eligibility criteria and underwent autologous stem cell transplant at New York Medical College and Zalmen A. Arlin Cancer Institute.	15512814
Lymphoma, Non-Hodgkin, Familial, HD Term Type	Stem Cell Exhaustion	One hundred patients, 37 with HD and 63 with NHL underwent autologous stem cell transplant using TMJ as a conditioning regimen.	15512814
Lymphoma, Non-Hodgkin, Familial, HD Term Type	Stem Cell Exhaustion	With a median follow up of 91 months (range 23-147 months), the median survival of patients with HD and NHL who underwent autologous stem cell transplant is 107 months and the 5 years disease free survival is 43%.	15512814
Lymphoma, Non-Hodgkin, Familial, HD Term Type, Temporomandibular Joint Dysfunction Syndrome	Stem Cell Exhaustion	TMJ is a safe and effective regimen when used as a part of autologous stem cell transplant for patients with HD and NHL.	15512814
Neoplasms, Multiple Myeloma	Stem Cell Exhaustion	Tandem stem cell transplantation is an important treatment option for patients with myeloma and some additional tumors.	15512916
Neoplasms, Multiple Myeloma	Stem Cell Exhaustion	In an attempt to reduce the contamination of the stem cell graft with tumor cells, patients with myeloma who entered complete remission after the first transplant underwent a second episode of mobilization to obtain progenitor cells for the second transplant.	15512916
Infection	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (allo-SCT) recipients are prone to infections.	15516933
Amyloidosis	Stem Cell Exhaustion	Risk-adjusted manipulation of melphalan dose before stem cell transplantation in patients with amyloidosis is associated with a lower response rate.	15516945
Amyloidosis	Stem Cell Exhaustion	High-dose chemotherapy and autologous stem cell transplantation are used increasingly to treat patients with light-chain-related amyloidosis (AL).	15516945
Candidemia	Stem Cell Exhaustion	Candidaemia in allogeneic stem cell transplant recipients: low risk without fluconazole prophylaxis.	15517009
Osteoporotic Fractures	Stem Cell Exhaustion	High affinity leptin receptors are present in human mesenchymal stem cells (MSCs) derived from control and osteoporotic donors.	15517602
Encephalitis	Stem Cell Exhaustion	A new complication of stem cell transplantation: measles inclusion body encephalitis.	15520095
Seizures, Chronic granulomatous disease	Stem Cell Exhaustion	We report a 13-year-old boy who had chronic granulomatous disease and presented 38 days after stem cell transplantation with afebrile focal seizures that progressed despite multiple anticonvulsants.	15520095
Immunocompromised Host, Communicable Diseases	Stem Cell Exhaustion	MIBE has not been described in stem cell recipients but is a disease of immunocompromised hosts and typically occurs within 1 year of measles infection, exposure, or vaccination.	15520095
Hematologic Neoplasms	Stem Cell Exhaustion	We reviewed the records of 78 RhD-negative patients with hematologic malignancies who received RhD-negative bone marrow and/or peripheral blood stem cells, from June 1995 to August 2000.	15520646
Hematologic Neoplasms	Stem Cell Exhaustion	Transfusion of RhD-positive blood components to Rh-negative patients with hematologic cancers, who have received RhD-negative bone marrow and/or peripheral blood stem cells, are at low risk of developing RhD antibodies.	15520646
Hematologic Neoplasms	Stem Cell Exhaustion	Hematopoietic stem-cell transplantation from unrelated donors in elderly patients (age >55 years) with hematologic malignancies: older age is no longer a contraindication when using reduced intensity conditioning.	15526016
Hematologic Neoplasms	Stem Cell Exhaustion	Allogeneic stem cell transplantation (SCT) is a potentially curative approach for patients with hematological malignancies.	15526016
Peripheral Blood Stem Cells, Multiple Myeloma	Stem Cell Exhaustion	A phase I study of 153Sm-EDTMP with fixed high-dose melphalan as a peripheral blood stem cell conditioning regimen in patients with multiple myeloma.	15526021
Multiple Myeloma	Stem Cell Exhaustion	Despite response rates of 30% after high-dose chemotherapy with autologous hematopoietic stem cell transplant, patients with multiple myeloma are not cured.	15526021
Epithelial	Stem Cell Exhaustion	Myeloablative chemotherapy used prior stem cell transplantation produces epithelial injury including oral cavity.	15526844
Specialty Type - cancer	Stem Cell Exhaustion	New approaches to cancer therapy and stem cell production are suggested via non-thermal laser-mediated effects aimed at quantum optical states of centrioles.	15527951
Cessation of life, Neutropenia, Candida albicans, Candidiasis, leukemia, Candidemia	Stem Cell Exhaustion	On the bases of a reduced multivariate model, a significantly increased risk of death was found for patients with hematopoietic stem cell transplantation (odds ratio [OR]=2.51; 95% confidence interval [95% CI], 0.99-6.31; P <0.05), for patients with persistent neutropenia (OR=4.57; 95% CI, 1.99-10.47; P <0.0003), and for patients with leukemia who also had prolonged candidemia (OR=3.59; 95% CI, 1.61-7.98; P <0.002), disseminated candidiasis (OR=5.19; 95% CI, 2.17-12.42; P <0.0002), or non-C. albicans candidemia (OR=5.02; 95% CI, 1.07-23.64; P <0.04).	15529309
Chronic graft-versus-host disease	Stem Cell Exhaustion	Impact of HLA class I high-resolution mismatches on chronic graft-versus-host disease and survival of patients given hematopoietic stem cell grafts from unrelated donors.	15531903
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Stem cell transplantation from identical twins in patients with myelodysplastic syndromes.	15531907
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Phase I trial of iodine-131 tositumomab with high-dose chemotherapy and autologous stem-cell transplantation for relapsed non-Hodgkin's lymphoma.	15534357
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	To determine the maximum outpatient dose of iodine-131 tositumomab (up to 0.75 Gy) combined with high-dose carmustine, etoposide, cytarabine, and melphalan (BEAM) followed by autologous stem-cell transplantation (ASCT) for the treatment of chemotherapy-resistant relapsed or refractory B-cell non-Hodgkin's lymphoma (NHL).	15534357
Lymphopenia	Stem Cell Exhaustion	Long-term persistent lymphopenia in hematopoietic stem cell donors after donation for donor lymphocyte infusion.	15539080
Lymphopenia	Stem Cell Exhaustion	Grade I/II lymphopenia was present in 22 donors (29%) just before first apheresis for lymphocyte collection, demonstrating that former stem cell donation induced prolonged lymphopenia in a subset of donors.	15539080
Graft-vs-Host Disease	Stem Cell Exhaustion	CD8+ T cell dose affects development of acute graft-vs-host disease following reduced-intensity conditioning allogeneic peripheral blood stem cell transplantation.	15539088
Cerebral Hemorrhage, Leukoencephalopathy	Stem Cell Exhaustion	Successful treatment of tacrolimus (FK506)-related leukoencephalopathy with cerebral hemorrhage in a patient who underwent nonmyeloablative stem cell transplantation.	15540907
Hodgkin Disease, Left hemiparesis, Blindness, Cortical, Seizures, Graft-vs-Host Disease	Stem Cell Exhaustion	A 46-year-old woman with Hodgkin's disease who underwent nonmyeloablative allogeneic stem cell transplantation developed cortical blindness, seizures, and left hemiparesis on day 100 while receiving tacrolimus (FK506) and prednisone for the treatment of graft-versus-host disease (GVHD).	15540907
Leukoencephalopathy	Stem Cell Exhaustion	FK506-related leukoencephalopathy is a rare complication after allogeneic stem cell transplantation.	15540907
diabetic	Stem Cell Exhaustion	Several studies have shown that transplantation of embryonic stem cells into diabetic animals either improved or normalized blood glucose levels.	15541340
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Effects of pretransplantation treatment with rituximab on outcomes of autologous stem-cell transplantation for non-Hodgkin's lymphoma.	15542807
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	To analyze the effects of preautografting treatment with rituximab (R) on stem-cell mobilization, post-transplantation complications, engraftment, disease-free survival, and overall survival in patients with non-Hodgkin's lymphoma (NHL).	15542807
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Long-term follow-up of nonmyeloablative allogeneic stem cell transplantation for renal cell carcinoma: The University of Chicago Experience.	15543195
Renal Cell Carcinoma Pathway, Refractory Cytopenia of Childhood	Stem Cell Exhaustion	Nonmyeloablative allogeneic stem cell transplantation (NST) has considerable activity in patients with metastatic renal cell carcinoma (RCC), although there are limited long-term follow-up data.	15543195
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) has an established role in the treatment of symptomatic multiple myeloma (MM).	15543200
Neutropenia, Mycoses	Stem Cell Exhaustion	Micafungin versus fluconazole for prophylaxis against invasive fungal infections during neutropenia in patients undergoing hematopoietic stem cell transplantation.	15546073
Neutropenia	Stem Cell Exhaustion	We hypothesized that chemoprophylaxis with the echinocandin micafungin would be an effective agent for antifungal prophylaxis during neutropenia in patients undergoing hematopoietic stem cell transplantation (HSCT).	15546073
Central neuroblastoma	Stem Cell Exhaustion	High dose myeloablative chemotherapy ("megatherapy"), with haematopoietic stem cell support, is now widely used to consolidate response to induction chemotherapy in patients with advanced neuroblastoma.	15546135
Vasculitis	Stem Cell Exhaustion	Rapamycin attenuates vascular wall inflammation and progenitor cell promoters after angioplasty.	15546959
Multiple Myeloma	Stem Cell Exhaustion	To learn about the feelings, beliefs, and experiences of patients with multiple myeloma implementing an exercise program in the context of an aggressive tandem peripheral stem cell transplant protocol.	15547635
Urinary Incontinence, CTCAE 5.0	Stem Cell Exhaustion	[Stem cell therapy for urinary incontinence].	15549161
Urinary Incontinence, CTCAE 5.0	Stem Cell Exhaustion	The experimental as well as the clinical data clearly demonstrate that urinary incontinence can be treated effectively with autologous stem cells.	15549161
Infarction	Stem Cell Exhaustion	Autologous bone marrow-derived progenitor cell transplantation for myocardial regeneration after acute infarction.	15551805
Infarction	Stem Cell Exhaustion	This pilot trial reports investigation of safety and feasibility of autologous bone marrow-derived progenitor cell therapy for faster regeneration of the myocardium after infarction.	15551805
Acute myocardial infarction	Stem Cell Exhaustion	Experimental and first clinical studies suggest that the transplantation of bone marrow derived, or circulating blood progenitor cells, may beneficially affect postinfarction remodelling processes after acute myocardial infarction.	15551805
Peripheral Blood Stem Cells, Pleural Effusion, CTCAE	Stem Cell Exhaustion	After control of the massive pleural effusion by chest tube drainage, peripheral blood stem cell (PBSC) collection was performed with cyclophosphamide and G-CSF.	15553046
Hypercholesterolemia	Stem Cell Exhaustion	[Hypercholesterolemia as a part of chronic GVHD after allogeneic stem cell transplantation].	15553047
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 45-year-old female with acute myelogenous leukemia (AML-M6) received an allogeneic stem cell transplantation from an HLA-identical sibling donor in June 2002.	15553047
Graft-vs-Host Disease, Jaundice, Obstructive	Stem Cell Exhaustion	Hepatic graft-versus-host disease (GVHD) post allogeneic hematopoietic stem cell transplantation generally presents as cholestatic jaundice and increased serum alkaline phosphatase (ALK-P).	15553801
Liver damage	Stem Cell Exhaustion	We describe a 25-year-old female who initially had no liver damage at all after an allogeneic peripheral blood stem cell transplantation (allo-PBSCT) from her HLA-indentical sister.	15553801
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We report an interesting case of a 35-year-old male with a clinical history of chronic myelogenous leukemia post allogeneic peripheral blood stem cell transplantation and complete molecular remission, who was found to have chloroma of the left testis.	15553811
Traumatic	Stem Cell Exhaustion	Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: case report.	15555520
Calvarial	Stem Cell Exhaustion	Due to the limited amount of autologous cancellous bone available from the iliac crest, autologous adipose derived stem cells were processed simultaneously and applied to the calvarial defects in a single operative procedure.	15555520
Cerebral Hemorrhage	Stem Cell Exhaustion	A patient with intracerebral hemorrhage is considered ineligible for hematopoietic stem cell transplantation (HSCT).	15558806
Neutropenia, Hematologic Neoplasms	Stem Cell Exhaustion	Most patients had a hematological malignancy (53.8%) or hematopoietic stem cell transplantation (23.0%), were neutropenic (61.5%), and were refractory to previous amphotericin B (92.3%).	15561860
Amyloidosis	Stem Cell Exhaustion	High-dose melphalan with autologous stem cell transplantation after VAD induction chemotherapy for treatment of amyloid light chain amyloidosis: a single centre prospective phase II study.	15566357
Coronary Arteriosclerosis	Stem Cell Exhaustion	Granulocyte colony-stimulating factor mobilizes functional endothelial progenitor cells in patients with coronary artery disease.	15569821
Coronary Arteriosclerosis, Vascular System Injuries	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) that may repair vascular injury are reduced in patients with coronary artery disease (CAD).	15569821
Coronary Arteriosclerosis	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) are reduced in coronary artery disease.	15569821
Hematologic Neoplasms	Stem Cell Exhaustion	Use of a T cell-specific monoclonal antibody, T10B9, in a novel allogeneic stem cell transplantation protocol for hematologic malignancy high-risk patients.	15570254
Toxic effect	Stem Cell Exhaustion	To reduce the toxicity of traditional conditioning regimens for allogeneic stem cell transplantation (allo-SCT), we used single-agent chemotherapy conditioning with either busulfan (total cumulative dose, 16 mg/kg) or melphalan (200 to 240 mg/m 2 ), followed by the anti-T cell-specific monoclonal antibody T10B9 (MEDI-500) daily for 3 days.	15570254
streptococcal bacteremia	Stem Cell Exhaustion	Viridans streptococcal bacteremia (VSB) after allogeneic hematopoietic stem cell transplantation (HSCT) is associated with substantial mortality.	15578362
Specialty Type - cancer	Stem Cell Exhaustion	Patient-rated emotional and physical functioning among hematologic cancer patients during hospitalization for stem-cell transplantation.	15580279
Hematologic Neoplasms	Stem Cell Exhaustion	In this 3-year prospective inpatient study, 220 patients received stem-cell transplantation (SCT) for hematologic cancer at a single institution.	15580279
Hematologic Neoplasms	Stem Cell Exhaustion	Can the stem cell mobilization technique influence CD34+ cell collection efficiency of leukapheresis procedures in patients with hematologic malignancies?	15580281
Hepatitis	Stem Cell Exhaustion	Progenitor cell expansion: an important source of hepatocyte regeneration in chronic hepatitis.	15582132
Chronic liver disease, Hepatitis, Chronic	Stem Cell Exhaustion	Progenitor cell activation with subsequent maturation to hepatocytes and cells of the biliary lineage has been demonstrated in a variety of chronic liver diseases but the kinetics and magnitude of the progenitor cell response has not been adequately studied in detail in chronic hepatitis.	15582132
Hepatitis	Stem Cell Exhaustion	We undertook this study to evaluate factors responsible for the progenitor cell/ductular response and further dissect the role of disease grade and stage as determinants of hepatocellular differentiation of bipotential progenitor cells in chronic hepatitis.	15582132
Hepatitis, Liver Dysfunction	Stem Cell Exhaustion	Progenitor cell derived hepatocytes accrue in chronic hepatitis, possibly related to native hepatocellular dysfunction.	15582132
Acute leukemia	Stem Cell Exhaustion	Low-dose prophylactic platelet transfusions in recipients of an autologous peripheral blood progenitor cell transplant and patients with acute leukemia: a randomized controlled trial with a sequential Bayesian design.	15584985
Hemorrhage, Acute leukemia	Stem Cell Exhaustion	Patients (n = 111) with acute leukemia or undergoing autologous peripheral blood progenitor cell (PBPC) transplantation were randomly assigned to receive low-dose (3 PLT units) or standard-dose (5 PLT units) prophylactic PLT transfusions and were monitored daily for bleeding.	15584985
Viremia	Stem Cell Exhaustion	The aim of the study was to evaluate the prevalence of HCV viremia in granulocyte colony-stimulating factor (G-CSF) mobilized peripheral blood progenitor cell (PBPC) donors by the use of a free HCV core antigen enzyme-linked immunosorbent assay (ELISA).	15584991
leukemia	Stem Cell Exhaustion	Allogeneic peripheral blood stem cell transplantation using reduced intensity versus myeloablative conditioning regimens for the treatment of leukemia.	15588514
Acute leukemia, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Between October, 1999, and June, 2003, 61 patients with acute leukemia or chronic myeloid leukemia received allogeneic peripheral blood hematopoietic stem cell transplantation (HSCT) from HLA-identical siblings.	15588514
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Stem Cell Exhaustion	Early consolidation by myeloablative radiochemotherapy followed by autologous stem cell transplantation in first remission significantly prolongs progression-free survival in mantle-cell lymphoma: results of a prospective randomized trial of the European MCL Network.	15591112
Nephroblastoma	Stem Cell Exhaustion	Effective use of high-dose chemotherapy and autologous stem cell rescue for relapsed adult Wilms' tumor and a novel alteration in intron 1 of the WT1 gene.	15591903
Hematopoietic stem cells	Stem Cell Exhaustion	Treosulphan has recently demonstrated antileukaemic activity and potent haematopoietic stem cell toxicity.	15592494
Hematologic Neoplasms	Stem Cell Exhaustion	Dose-escalated treosulphan (3 x 12 or 3 x 14 g/m2) combined with cyclophosphamide (Cy) was chosen for a new preparative regimen before allogeneic haematopoietic stem cell transplantation in 18 patients (median age 44, range 19-64 years) with haematological malignancies, considered ineligible for other myeloablative preparative regimens.	15592494
Rheumatoid Arthritis, Degenerative polyarthritis	Stem Cell Exhaustion	CD34+ cells purified from the bone marrow of 13 patients with active RA and 9 control subjects (7 osteoarthritis [OA] patients and 2 healthy individuals) were cultured in the presence of stem cell factor (10 ng/ml) and granulocyte-macrophage colony-stimulating factor (1 ng/ml).	15593185
Multiple Myeloma	Stem Cell Exhaustion	Stem cell mobilization in multiple myeloma patients: do we need an age-adjusted regimen for the elderly?	15597345
Multiple Myeloma	Stem Cell Exhaustion	Our data show that stem cell mobilization in older multiple myeloma patients is inferior compared to a younger patient population.	15597345
Multiple Myeloma	Stem Cell Exhaustion	The upper age limit for autologous progenitor cell transplantation in multiple myeloma patients is increasing continuously.	15597345
PAFAH1B1 wt Allele, Decreased platelet count	Stem Cell Exhaustion	Thirty-three patients (MDS, n=14; AA, n=16; prolonged thrombocytopenia following stem cell transplantation or chemotherapy, n=3) were evaluable.	15598951
Osteogenesis	Stem Cell Exhaustion	Here we report delayed ossification and decreased bone mineral density in caspase-3-deficient (Casp3(-/-) and Casp3(+/-)) mice due to an attenuated osteogenic differentiation of bone marrow stromal stem cells (BMSSCs).	15599395
Hematologic Neoplasms, Stomatitis	Stem Cell Exhaustion	This double-blind study compared the effect of palifermin with that of a placebo on the development of oral mucositis in 212 patients with hematologic cancers; 106 patients received palifermin (60 microg per kilogram of body weight per day) and 106 received a placebo intravenously for three consecutive days immediately before the initiation of conditioning therapy (fractionated total-body irradiation plus high-dose chemotherapy) and after autologous hematopoietic stem-cell transplantation.	15602019
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The question as to whether autologous stem cell transplantation (SCT) after consolidation chemotherapy improves the probability of survival of patients with acute myeloid leukaemia (AML) in first remission has not been settled.	15606550
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Conditioning with targeted busulfan for autologous peripheral blood stem cells transplantation for acute myelogenous leukemia in an XYY male.	15609287
Eosinophil count raised (finding), Disseminated eosinophilic collagen disease	Stem Cell Exhaustion	Hypereosinophilic syndrome: long-term remission following allogeneic stem cell transplant in spite of transient eosinophilia post-transplant.	15609294
Kidney Diseases	Stem Cell Exhaustion	[Membranous nephropathy following allogeneic peripheral blood stem cell transplantation in a boy with anaplastic large cell lymphoma].	15609686
Ki-1+ Anaplastic Large Cell Lymphoma, Anaplastic large B-cell lymphoma, Neoplasms	Stem Cell Exhaustion	Since anaplastic lymphoma kinase (ALK), one of the important prognostic factors of ALCL, was not expressed in the tumor cells, allogeneic peripheral blood stem cell transplantation (PBSCT) from his HLA-matched elder brother was performed.	15609686
Hematologic Neoplasms	Stem Cell Exhaustion	The clinical significance of H-Y antibodies was characterized in 75 male patients with hematologic malignancies who received stem cells from female donors (F --> M HSCT).	15613541
Infection	Stem Cell Exhaustion	Overall, 69% of the infections in hematopoietic stem cell transplant (HSCT) recipients and 53% of the infections in organ transplant recipients were disseminated.	15614697
Bacteremia, Kocuria	Stem Cell Exhaustion	Catheter-related bacteremia due to Kocuria rosea in a patient undergoing peripheral blood stem cell transplantation.	15615593
Bacteremia, Hodgkin Disease, Peripheral Stem Cell Transplantation, Kocuria	Stem Cell Exhaustion	We report on the first case of a catheter-related bacteremia caused by Kocuria rosea, a gram-positive microorganism belonging to the family Micrococcaceae, in a 39-year-old man undergoing peripheral blood stem cell transplantation due to relapsed Hodgkin disease.	15615593
Bacteremia, Kocuria	Stem Cell Exhaustion	This report presents a case of Kocuria rosea catheter related bacteremia after stem cell transplantation successfully treated with vancomycin and by catheter removal.	15615593
Multiple Myeloma	Stem Cell Exhaustion	Circulating endothelial progenitor cells in multiple myeloma: implications and significance.	15618473
Pichia kudriavzevii	Stem Cell Exhaustion	Ultimately, the patient underwent an allogeneic peripheral blood hematopoietic progenitor cell transplant from a human leukocyte antigen-identical brother, but he died 5 days after transplantation of overwhelming Candida kruseii infection.	15620459
Primary amyloidosis	Stem Cell Exhaustion	Autologous stem cell transplantation in patients with primary amyloidosis: a nation-wide survey.	15621765
Primary amyloidosis	Stem Cell Exhaustion	Due to poor prognosis with conventional therapy, high-dose therapy (HDT) with autologous stem cell transplantation (ASCT) is considered for treatment in patients with primary amyloidosis (AL).	15621765
Liver Failure, Primary Myelofibrosis	Stem Cell Exhaustion	Fatal hepatic failure associated with graft rejection following reduced-intensity stem-cell transplantation for chronic idiopathic myelofibrosis (CIMF).	15621770
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Intensified induction chemotherapy in adult acute myeloid leukemia followed by high-dose chemotherapy and autologous peripheral blood stem cell transplantation: an Eastern Cooperative Oncology Group trial (E4995).	15621781
Peripheral Stem Cell Transplantation, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The feasibility of intensified therapy in adults < 61-years-old with de novo acute myeloid leukemia (AML) was evaluated by adding high-dose cytarabine (HDAC) to conventional induction therapy and in post-remission therapy prior to peripheral blood stem cell transplantation (PBSCT).	15621781
Mantle cell lymphoma	Stem Cell Exhaustion	Allogeneic stem cell transplantation for mantle cell lymphoma--does it deserve a better look?	15621804
Lymphoma	Stem Cell Exhaustion	The results of this series would suggest that in a selected group of patients allogeneic stem cell transplantation may be the treatment of choice for lymphomas not curable by standard therapy or autotransplant.	15621804
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Laboratory correlative studies were performed prior to treatment and at intervals during treatment to evaluate effects on maturation and differentiation, and on CML progenitor cell growth by assessment of colony-forming cells (CFC).	15621827
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	ATRA demonstrated clinical and hematological activity in 5 of 18 patients with the accelerated phase of CML, and there was evidence of a biological effect in laboratory studies of 3 of the 5 patients' progenitor cells.	15621827
Lymphoma, Non-Hodgkin, Familial, Hodgkin Disease, HD Term Type, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Dose-intensive chemotherapy with autologous stem cell support is commonly used in resistant/refractory cases of Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL).	15621831
Lymphoma, Non-Hodgkin, Familial, HD Term Type	Stem Cell Exhaustion	Twenty-nine patients with HD and 47 with NHL underwent autologous stem cell transplant using TMJ as the conditioning regimen for the first transplant.	15621831
Multiple Myeloma	Stem Cell Exhaustion	Results of a multicenter randomized phase II trial of thalidomide and prednisone maintenance therapy for multiple myeloma after autologous stem cell transplant.	15623591
Lymphoma	Stem Cell Exhaustion	High-dose carmustine, etoposide, and cisplatin for autologous stem cell transplantation with or without involved-field radiation for relapsed/refractory lymphoma: an effective regimen with low morbidity and mortality.	15625540
Septicemia, Multiple Organ Failure, Pulmonary Embolism	Stem Cell Exhaustion	Four patients (4%) died within 30 days of stem cell infusion (1 pulmonary embolism, 2 septicemias with multiorgan failure, and 1 progressive lymphoma).	15625540
Aplastic Anemia, CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology	Stem Cell Exhaustion	To explore the defect of hematopoietic stem cell and analyze the relationship between the colony formation capacity of bone marrow hematopoietic progenitor cells and the results of immunosuppressive therapy (IST) in severe aplastic anemia (SAA) patients.	15625831
Damage, CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology	Stem Cell Exhaustion	In the majority of SAA patients, the hematopoietic stem cells or progenitors were defective perhaps caused by immune damage; IST can improve the hematopoiesis in vitro and in vivo of SAA patients.	15625831
Aplastic Anemia	Stem Cell Exhaustion	[Colony formation of bone marrow hematopoietic progenitor cells in patients with severe aplastic anemia and its relation to the results of immunosuppressive therapy].	15625831
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	[Unrelated peripheral blood stem cell transplantation for a patient with acute myeloid leukemia].	15625842
Hematologic Neoplasms	Stem Cell Exhaustion	To carry out unrelated donor peripheral blood stem cell transplantation for treatment of hematological malignancies, and to observe the persistent hematopoietic reconstitution and transplantation related complications.	15625842
Peripheral Blood Stem Cells, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 11-year-old boy with acute myeloid leukemia, who was in second CR, received peripheral blood stem cell transplantation from a unrelated healthy adult donor.	15625842
Communicable Diseases	Stem Cell Exhaustion	Polymerase chain reaction in the management of disseminated adenovirus infection after stem cell transplantation.	15626960
Communicable Diseases	Stem Cell Exhaustion	We report a 20-month-old child with disseminated adenovirus infection after a haploidentical T cell-depleted stem cell transplantation.	15626960
Adenovirus Infections	Stem Cell Exhaustion	It also emphasizes the importance of T cell immunity in controlling disseminated adenovirus infection after stem cell transplantation.	15626960
Adenocarcinoma of lung (disorder), Neoplasms	Stem Cell Exhaustion	The tyrosine-kinase receptor c-kit (CD117) and its ligand stem cell factor are considered to be co-expressed in various solid tumors, including adenocarcinomas of the lung.	15627886
Hematological Disease, Thrombocythemia, Essential	Stem Cell Exhaustion	Essential thrombocytosis is a disorder of the hematopoietic stem cell that causes proliferation of platelets.	15627933
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	To explore the relationship between evolution of karyotype and clinical progress in myelodysplastic syndromes (MDS) and estimate the clinical outcomes of high risk patients received allogeneic hematopoietic stem cell transplantation (allo-HSCT).	15634565
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	[Study on the Characteristics of cell cycle and proliferation of CD34+ hematopoietic stem cells in myelodysplastic syndromes].	15634564
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	To study the characteristics of cell cycle and proliferation of CD34+ hematopoietic stem cells in patients with myelodysplastic syndromes (MDS).	15634564
Multiple Myeloma	Stem Cell Exhaustion	[The treatment of multiple myeloma with an allogeneic peripheral blood stem cell transplantation using a non-myeloablative conditioning regimen].	15635796
Multiple Myeloma	Stem Cell Exhaustion	Between November 1998 and October 1999 authors treated five multiple myeloma patients with an allogeneic peripheral blood stem cell transplantation from HLA-identical sibling using a non-myeloablative conditioning regimen.	15635796
Toxic effect, Multiple Myeloma	Stem Cell Exhaustion	It can be concluded that allogenic peripheral blood stem cell transplantation using a non-myeloablative conditioning regimen is an effective way of the multiple myeloma treatment with an acceptable toxicity.	15635796
Left Ventricular Function	Stem Cell Exhaustion	High-dose chemotherapy with administration of peripheral stem cells did not lead to marked deterioration of left ventricular function as compared with patients who did not undergo this treatment.	15637892
Fanconi Anemia	Stem Cell Exhaustion	Fludarabine-based conditioning for allogeneic stem cell transplantation for multiply transfused patients with Fanconi's anemia.	15640819
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	One patient who developed acute myeloid leukemia on day 56 underwent successful induction with cytosine and daunorubicin followed by peripheral blood stem cell (PBSC) rescue on day 70 and is presently in remission with complete donor chimerism and grade I GVHD.	15640819
Multiple Myeloma	Stem Cell Exhaustion	Hematopoietic stem cell mobilization with intravenous melphalan and G-CSF in patients with chemoresponsive multiple myeloma: report of a phase II trial.	15640822
Hematologic Neoplasms	Stem Cell Exhaustion	Multiple myeloma (MM) is an incurable hematologic malignancy for which autologous hematopoietic stem cell transplantation (HCT) is a standard therapy.	15640822
Infection of bloodstream	Stem Cell Exhaustion	Difference in time to positivity is useful for the diagnosis of catheter-related bloodstream infection in hematopoietic stem cell transplant recipients.	15640824
Bacteremia	Stem Cell Exhaustion	In conclusion, differential time to positivity of 120 min or more is sensitive and specific for catheter-related bacteremia in hematopoietic stem cell transplant recipients who have nontunnelled short-term catheters.	15640824
Engraftment syndrome, Communicable Diseases	Stem Cell Exhaustion	Steroids prevent engraftment syndrome after autologous hematopoietic stem cell transplantation without increasing the risk of infection.	15640827
Exanthema, Fever, Engraftment syndrome	Stem Cell Exhaustion	Engraftment syndrome (ES) following autologous hematopoietic stem cell transplantation (AHSCT) is characterized by fever and rash.	15640827
Rheumatoid Arthritis	Stem Cell Exhaustion	Depletion of endothelial progenitor cells in the peripheral blood of patients with rheumatoid arthritis.	15642766
Rheumatoid Arthritis	Stem Cell Exhaustion	Because the quantity of endothelial progenitor cells (EPCs) in the peripheral blood is correlated inversely with cardiovascular risk, we studied whether such abnormalities could also be observed in patients with RA.	15642766
Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	[Stem cell transplantation for paroxysmal nocturnal hemoglobinuria].	15645835
Complication Aspects, Hemolysis (biological function), Aplastic Anemia	Stem Cell Exhaustion	Stem cell transplantation is indicated in patients with severe bone marrow aplasia, repeated massive hemolysis or recurrent life threatening thrombotic complications.	15645835
Intravascular hemolysis, Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	We report a case of successful allogeneic peripheral blood stem cell transplantation performed in a 24 years old woman with a severe form of PNH with frequent episodes of massive intravascular hemolysis.	15645835
bone marrow fibrosis, Primary Myelofibrosis	Stem Cell Exhaustion	[Complete regression of bone marrow fibrosis following allogeneic peripheral blood stem cell transplantation in a patient with idiopathic myelofibrosis].	15645853
Failure	Stem Cell Exhaustion	Because of progression of the disease and failure of hematopoiesis in 2002, allogeneic peripheral blood stem cell transplantation was performed; the donor was an HLA identical relative.	15645853
B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1	Stem Cell Exhaustion	Philadelphia chromosome-positive acute lymphoblastic leukemia rescued with a second allogeneic stem cell transplantation from a haploidentical mother after relapse following cord blood transplantation.	15646659
Peripheral Blood Stem Cells	Stem Cell Exhaustion	After reinduction with imatinib mesylate, unmanipulated peripheral blood stem cell transplantation was performed from the patient's haploidentical mother with a reduced-intensity conditioning regimen.	15646659
Diarrhea	Stem Cell Exhaustion	Experience with the use of salazosulfapyridine for intractable diarrhea after hematopoietic stem cell transplantation.	15646661
Diarrhea	Stem Cell Exhaustion	We encountered 2 children with intractable diarrhea after allogeneic hematopoietic stem cell transplantation (SCT).	15646661
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	A 32-year-old Caucasian man with chronic myeloid leukemia, never transfused, conditioned with BuCy120, received granulocyte-colony-stimulating factor-mobilized peripheral blood progenitor cells from his HLA-identical sister.	15647013
Fragile X Syndrome	Stem Cell Exhaustion	Neural progenitor cells from an adult patient with fragile X syndrome.	15649335
nervous system disorder, Fragile X Syndrome	Stem Cell Exhaustion	By modifying published methods for the harvest of neural progenitor cells from the post-mortem human brain, neural cells were successfully harvested and grown from post-mortem brain tissue of a 25-year-old adult male with fragile X syndrome, and from brain tissue of a patient with no neurological disease.	15649335
Fragile X Syndrome	Stem Cell Exhaustion	The cultured fragile X cells displayed many of the characteristics of neural progenitor cells, including nestin and CD133 expression, as well as the biochemical hallmarks of fragile X syndrome, including CGG repeat expansion and a lack of FMRP expression.	15649335
European Organization for Research and Treatment of Cancer	Stem Cell Exhaustion	The EORTC QLQ-C30 and the EuroQol-5D were administered 2 wk after completion of vincristine, adriamycin and dexamethason/vincristine, adriamycin and methyl prednison (VAD/VAMP) chemotherapy, both at hospital discharge after treatment with high-dose melphalan (HDM) and 1 month after this hospital discharge, at hospital admission, at the day of hospital discharge for peripheral stem cell transplantation (PSCT) and at 6 and 12 months following discharge after PSCT.	15654905
Hematologic Neoplasms	Stem Cell Exhaustion	Conventional versus reduced-intensity conditioning regimen for allogeneic stem cell transplantation in patients with hematological malignancies.	15654906
Malignant Neoplasms	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HSCT) from human leukocyte antigen (HLA)-compatible sibling donors is a potential curative treatment for hematological and non-hematological malignancies.	15654906
Graft-vs-Host Disease, Chronic graft-versus-host disease, Polymyositis	Stem Cell Exhaustion	Polymyositis usually occurred along with other manifestations of chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT) had been reported.	15654909
Aggressive Non-Hodgkin Lymphoma, T-Cell Lymphoma	Stem Cell Exhaustion	T-cell lymphoma is an aggressive lymphoma that cannot be cured despite aggressive therapy, including autologous stem cell transplantation.	15654910
Multiple Myeloma	Stem Cell Exhaustion	To reduce treatment-related mortality, while retaining the cytoreductive effects of high-dose chemotherapy, as well as graft vs. myeloma effect, we used a reduced-intensity conditioning umbilical cord blood (CB) transplantation following high-dose chemotherapy with autologous stem cell transplantation support.	15654912
malignant disease	Stem Cell Exhaustion	To examine health-related quality of life (HRQOL) and growth, and spiritual well-being in adult survivors of hematopoietic stem-cell transplantation (HSCT) for a malignant disease.	15659507
Lupus Erythematosus	Stem Cell Exhaustion	Use of CD34+ autologous stem cell transplantation in the treatment of children with refractory systemic lupus erythematosus.	15662487
Lupus Erythematosus, Encephalitis, St. Louis	Stem Cell Exhaustion	We report on the unique effects and benefits of autologous stem cell transplantation in childhood systemic lupus erythematosus (SLE) and describe this procedure in two young girls with severe and refractory disease.	15662487
Encephalitis, St. Louis	Stem Cell Exhaustion	The effect of this conditioning regimen plus CD34+ autologous stem cell transplantation on these two children with refractory SLE was beneficial, but long-term follow-up data and additional experience with this procedure are required.	15662487
Toxic effect, Encephalitis, St. Louis	Stem Cell Exhaustion	Autologous stem cell transplantation may limit the long-term toxicity of therapy in childhood SLE.	15662487
Chemosensitivity	Stem Cell Exhaustion	Afterwards, those patients who were chemosensitive, underwent high-dose chemotherapy with autologous peripheral blood stem-cell transplantation.	15662753
TAL1 gene	Stem Cell Exhaustion	Allogeneic stem-cell transplantation with reduced conditioning intensity as a novel immunotherapy and antiviral therapy for adult T-cell leukemia/lymphoma.	15665110
Adult T-Cell Lymphoma/Leukemia, TRPV6 wt Allele	Stem Cell Exhaustion	Sixteen patients with adult T-cell leukemia/lymphoma (ATL) who were all over 50 years of age underwent allogeneic stem cell transplantation with reduced-conditioning intensity (RIST) from HLA-matched sibling donors after a conditioning regimen consisting of fludarabine (180 mg/m2), busulfan (8 mg/kg), and rabbit antithymocyte globulin (5 mg/kg).	15665110
Bacteremia	Stem Cell Exhaustion	Value of surveillance blood culture for early diagnosis of occult bacteremia in patients on corticosteroid therapy following allogeneic hematopoietic stem cell transplantation.	15665840
Behavioral Symptoms Index Composite Score (BASC-2), Infection of bloodstream	Stem Cell Exhaustion	Bloodstream infection (BSI) is a significant complication following allogeneic hematopoietic stem cell transplantation (allo-SCT).	15665840
Amyloidosis	Stem Cell Exhaustion	Predictive factors for hematopoietic engraftment after autologous peripheral blood stem cell transplantation for AL amyloidosis.	15665842
Blood Vessel	Stem Cell Exhaustion	These patients, who frequently have amyloid deposits in bone marrow blood vessels and interstitium and impaired function of kidneys, liver, spleen, and heart, represent an unusual population for stem cell transplantation, with unique problems.	15665842
Delirium, Dementia, Amnestic, Cognitive Disorders, Amyloidosis	Stem Cell Exhaustion	Treatment of patients with AL amyloidosis with high-dose melphalan and autologous peripheral blood stem cells (PBSC) produces hematologic remissions in approximately 40% of evaluable patients, accompanied by improvements in organ disease and quality of life.	15665842
Graft-vs-Host Disease	Stem Cell Exhaustion	UVA1 as an adjunct to systemic immunosuppressive treatment was found to be safe, and effective in 10 patients with chronic cutaneous (seven lichenoid and three sclerodermoid) graft-versus-host disease (GVHD) after stem cell transplantation.	15665847
Hematologic Neoplasms	Stem Cell Exhaustion	Bone marrow and blood stem cell transplantation is now used as curative therapy for a range of haematological malignancies and other conditions.	15667464
Multiple Myeloma	Stem Cell Exhaustion	Biological modifiers as cytoreductive therapy before stem cell transplant in previously untreated patients with multiple myeloma.	15668273
Multiple Myeloma	Stem Cell Exhaustion	High dose chemotherapy with supporting autologous stem cell transplantation is now considered the treatment of choice in patients with multiple myeloma <65 years old.	15668273
Multiple Myeloma	Stem Cell Exhaustion	Thirty-six patients, previously untreated with diagnosis of multiple myeloma were enrolled to received the DAI regimen (dexamethasone 30 mg/m(2), i.v., days 1-4, all-trans-retinoic acid 45 mg/m(2), p.o., days 5-14 and interferon alpha 2a, 4.5 MU s.c., days 5-14) administered every 28 days for six cycles before high-dose chemotherapy (melphalan 200 g/m(2)) and autologous stem cell transplantation.	15668273
Toxic effect	Stem Cell Exhaustion	This regimen appears to be an excellent alternative as cytoreductive treatment before high-dose chemotherapy and autologous stem cell transplantation with excellent overall response and minimal toxicity.	15668273
Fever, Hematological Disease	Stem Cell Exhaustion	Blood samples were collected twice per week from 128 patients with hematologic diseases during periods of neutropenic fever after undergoing chemotherapy or hematopoietic stem cell transplantation.	15668862
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The stem cell marker CD34 is expressed by leukemia blasts only for a subset of patients with acute myelogenous leukemia (AML).	15668952
Primary Myelofibrosis	Stem Cell Exhaustion	Allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning in intermediate- or high-risk patients with myelofibrosis with myeloid metaplasia.	15671439
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Value of chemotherapy before allogeneic hematopoietic stem cell transplantation from an HLA-identical sibling donor for myelodysplastic syndrome.	15674354
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (allo-SCT) is a curative treatment for myelodysplastic syndrome (MDS).	15674354
Hematological Disease	Stem Cell Exhaustion	[Outcome of allogeneic stem cell transplantation for hematological disorders in patients older than 50].	15675581
Amyloidosis	Stem Cell Exhaustion	VAD with or without subsequent high-dose melphalan followed by autologous stem cell support in AL amyloidosis: Japanese experience and criteria for patient selection.	15678759
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Prognostic factors for outcomes of patients with refractory or relapsed acute myelogenous leukemia or myelodysplastic syndromes undergoing allogeneic progenitor cell transplantation.	15682071
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic progenitor cell transplantation is the only curative therapy for patients with refractory acute myelogenous leukemia or myelodysplastic syndromes.	15682071
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Long-term follow-up after autologous hematopoietic stem cell transplantation for low-grade non-Hodgkin lymphoma.	15682074
Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation (AHSCT) in low-grade non-Hodgkin lymphoma (NHL) can result in a prolonged remission, although most patients eventually relapse and die of their disease.	15682074
Bone necrosis	Stem Cell Exhaustion	Decreased osteogenic differentiation of mesenchymal stem cells in alcohol-induced osteonecrosis.	15685079
Bone necrosis	Stem Cell Exhaustion	We postulated that osteogenic and adipogenic differentiation ability of the mesenchymal stem cells isolated from the bone marrow could be altered in patients with alcohol-induced osteonecrosis of the femoral head.	15685079
Femoral Neck Fractures, Bone necrosis	Stem Cell Exhaustion	To examine this hypothesis, we investigated the differentiation ability of the mesenchymal stem cells isolated from the bone marrow from the proximal end of the femur during hip replacements in patients with alcohol-induced osteonecrosis of the femoral head and compared it with the differentiation ability of patients with femoral neck fractures.	15685079
Bone necrosis	Stem Cell Exhaustion	The altered function of mesenchymal stem cells can be responsible for the pathogenesis of osteonecrosis.	15685079
Specialty Type - cancer	Stem Cell Exhaustion	A 42-year-old male patient with relapsing germ-cell cancer was enrolled in a salvage protocol that employed two 4-day courses of CTC high-dose chemotherapy with cyclophosphamide (1,500 mg m(-2) day(-1)), thiotepa (120 mg m(-2) day(-1)), and carboplatin, followed by peripheral blood progenitor cell support.	15685452
Lymphoma, Follicular	Stem Cell Exhaustion	High-dose therapy followed by autologous purged stem-cell transplantation and doxorubicin-based chemotherapy in patients with advanced follicular lymphoma: a randomized multicenter study by GOELAMS.	15687232
Lymphoma, Follicular	Stem Cell Exhaustion	High-dose chemotherapy with stem-cell support is effective in follicular lymphoma in relapse but remains controversial as a first-line therapy.	15687232
Lymphoma, Follicular	Stem Cell Exhaustion	In a randomized study using a purged autologous stem-cell support, we compared these 2 approaches in patients with advanced follicular lymphoma.	15687232
Lymphoma, Follicular	Stem Cell Exhaustion	Newly diagnosed advanced follicular lymphoma patients (172 patients) were randomly assigned either to an immunochemotherapy regimen (cyclophosphamide, doxorubicin, teniposide, prednisone, and interferon) or to a high-dose therapy followed by purged autologous stem-cell transplantation.	15687232
Lymphoma, Follicular, Neoplasms	Stem Cell Exhaustion	Autologous stem-cell transplantation cannot be considered as the standard first-line treatment of follicular lymphoma for patients younger than 60 years old with a high tumor burden.	15687232
Acute myocardial infarction	Stem Cell Exhaustion	We have investigated the use of human umbilical cord blood mononuclear progenitor cells (HUCBC) for the treatment of acute myocardial infarction.	15690974
Hematologic Neoplasms	Stem Cell Exhaustion	Forty-three patients had undergone haematopoietic stem cell transplantation and 56 patients had been treated with conventional chemotherapy for haematological malignancy.	15693789
Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	Successful treatment with splenectomy and interferon alpha against recurred hemophagocytic syndrome in remission state of anaplastic large cell lymphoma following high-dose therapy and autologous peripheral blood stem cell transplantation.	15693797
Osteosarcoma	Stem Cell Exhaustion	Establishment and characterization of a KIT-positive and stem cell factor-producing cell line, KTHOS, derived from human osteosarcoma.	15693848
Stem Cell Factor	Stem Cell Exhaustion	The KTHOS cells were immunoreactive for osteocalcin, osteonectin, stem cell factor (SCF), and KIT (CD117).	15693848
Fatigue	Stem Cell Exhaustion	Fatigue and fatigue-relieving strategies used by Hong Kong Chinese patients after hemopoietic stem cell transplantation.	15695939
Fatigue	Stem Cell Exhaustion	Fatigue, a common symptom for patients after hemopoietic stem cell transplantation (HSCT), can be relieved by specific strategies initiated by patients, provided the strategies are perceived as effective.	15695939
Kidney Failure, Acute, Amyloidosis	Stem Cell Exhaustion	Acute renal insufficiency after high-dose melphalan in patients with primary systemic amyloidosis during stem cell transplantation.	15696449
UROS gene	Stem Cell Exhaustion	Considering the severity of the disease, if HLA-matched sibling donor is not available, haematopoietic stem cell transplantation using a matched unrelated donor should be strongly considered for treating congenital erythropoietic porphyria since this is currently the only known curative therapy.	15703981
Hematologic Neoplasms	Stem Cell Exhaustion	The advancement of hematopoietic stem cell transplantation techniques and the increase in frequency of hematological malignancy in older patients are expected to expand the indications to include more elderly patients.	15704660
Amyloidosis	Stem Cell Exhaustion	Early lymphocyte recovery predicts superior survival after autologous hematopoietic stem cell transplantation for patients with primary systemic amyloidosis.	15709191
Hematologic Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	Absolute lymphocyte count recovery at day 15 (ALC-15) post-autologous stem cell transplantation (ASCT) is a powerful prognostic indicator for survival for multiple hematologic malignancies and metastatic breast cancer.	15709191
Primary Biliary Cholangitis, Autoimmune Chronic Hepatitis	Stem Cell Exhaustion	We have reported quantitative and qualitative differences in bone marrow (BM) progenitor cells in autoimmune hepatitis type-1 (AIH-1) and primary biliary cirrhosis (PBC).	15710223
Lymphoma	Stem Cell Exhaustion	Phase II study of a single pegfilgrastim injection as an adjunct to chemotherapy to mobilize stem cells into the peripheral blood of pretreated lymphoma patients.	15710576
Lymphoma	Stem Cell Exhaustion	The aim of this study was to evaluate the efficacy of pegfilgrastim, in combination with salvage chemotherapy, in mobilizing CD34(+) stem cells into the peripheral blood of pretreated lymphoma patients.	15710576
Coronary Arteriosclerosis	Stem Cell Exhaustion	Patients with coronary artery disease who undergo FDG, PET for therapy monitoring after intracoronary progenitor cell infusion (PCT) show an increased bone marrow uptake in some cases.	15711724
Pfaundler-Hurler Syndrome	Stem Cell Exhaustion	Safety and efficacy of enzyme replacement therapy in combination with hematopoietic stem cell transplantation in Hurler syndrome.	15714083
Febrile Neutropenia, Acute leukemia	Stem Cell Exhaustion	We retrospectively reviewed the medical records of 284 patients with neutropenic fever following chemotherapy for acute leukemia at the Catholic Hematopoietic Stem Cell Transplantation Center from January 1998 to December 1999, to identify prognostic factors for infection-related mortality.	15716598
Vulva, Adenocarcinoma in Situ, Paget Disease Extramammary	Stem Cell Exhaustion	Primary cutaneous Paget's disease of the vulva is an intraepithelial adenocarcinoma most likely arising from a cutaneous stem cell with sweat gland epithelial differentiation or can be of sweat gland origin.	15717759
Supratentorial Embryonal Tumor, Not Otherwise Specified, Medulloblastoma	Stem Cell Exhaustion	High-dose chemotherapy with autologous stem cell rescue for children with high risk and recurrent medulloblastoma and supratentorial primitive neuroectodermal tumors.	15719272
Hematologic Neoplasms	Stem Cell Exhaustion	We have studied the influence of cell subsets [CD34, CD3, CD4, CD8, CD14, CD20, natural killer (NK; CD3(-)/CD56(+)), NKT (CD3(+)/CD56(+)), DC1, and DC2 cells] of granulocyte colony-stimulating factor mobilized peripheral blood stem cells (PBSC) on early T-cell chimaerism and later clinical outcomes in 125 patients with haematological malignancies who received human leucocyte antigen (HLA)-matched related grafts after non-myeloablative conditioning.	15725088
Disease, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are comprised of a heterogeneous group of stem cell disorders characterized by ineffective hematopoiesis and susceptibility to transform to acute myeloid leukemia.	15725481
Sepsis, Central neuroblastoma	Stem Cell Exhaustion	Case report of a 13-yr-old patient after autologous peripheral blood stem cell transplant for stage III neuroblastoma with sepsis and hemodynamic instability who survived to discharge after a 6-day course of extracorporeal membrane oxygenation (ECMO) support.	15730609
Neoplasms	Stem Cell Exhaustion	We hypothesized that the presence of tumor cells in bone marrow (BM) could alter hematopoietic progenitor cell functions.	15730855
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Tumor cells, malignant	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are clonal malignant stem cell disorders characterized by inefficient hematopoiesis.	15735749
Hodgkin Disease	Stem Cell Exhaustion	Prognostic factors affecting long-term outcome after stem cell transplantation in Hodgkin's lymphoma autografted after a first relapse.	15737986
Failure, Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	To analyse outcome and prognostic factors for overall survival (OS) and time to treatment failure (TTF) in 357 patients with Hodgkin's lymphoma (HL) undergoing an autologous stem cell transplantation (ASCT) after a first relapse and reported to the The Grupo Espanol de Linfomas/Trasplante Autologo de Medula Osea (GEL/TAMO) Cooperative Group.	15737986
Acute GVH disease	Stem Cell Exhaustion	The FcgammaRIIa-polymorphic site as a potential target for acute graft-versus-host disease in allogeneic stem cell transplantation.	15744239
Graft-vs-Host Disease, Hematological Disease	Stem Cell Exhaustion	Graft-versus-host disease (GVHD) is a serious complication of allogeneic stem cell transplantation for hematologic diseases.	15744239
Communicable Diseases	Stem Cell Exhaustion	Patients undergoing autologous hematopoietic stem cell transplantation (autoHCT) are at increased risk for infection with Streptococcus pneumoniae and have impaired antibody responses to pneumococcal polysaccharide vaccines.	15744240
Chemoradiotherapy	Stem Cell Exhaustion	Effects of race or ethnicity on survival after high-dose chemoradiation followed by stem cell transplantation (SCT) have not been thoroughly evaluated.	15744242
Lupus Erythematosus	Stem Cell Exhaustion	Autologous peripheral blood stem cell transplantation with in vivo T-cell depletion for life threatening refractory systemic lupus erythematosus.	15751821
Lupus Erythematosus, Encephalitis, St. Louis	Stem Cell Exhaustion	We report the first Australian application of autologous haemopoietic stem cell transplantation in a 39-year old woman with severe systemic lupus erythematosus (SLE) and multiple life threatening complications, refractory to conventional therapy including intravenous cyclophosphamide.	15751821
Cricoarytenoid Muscles, Airway Obstruction, Respiratory arrest	Stem Cell Exhaustion	Successful stem cell mobilization was achieved using granulocytecolony stimulating factor mobilization with methylprednisolone cover, after an initial attempt at mobilization was curtailed by respiratory arrest from upper airway obstruction due to cricoarytenoiditis, requiring tracheostomy.	15751821
Encephalitis, St. Louis	Stem Cell Exhaustion	We conclude that HSCT with unmanipulated peripheral stem cell graft and in vivo lymphocyte depletion with ATG is safe and effective therapy for cyclophosphamide refractory SLE.	15751821
Postthrombotic Syndrome, Acute lymphocytic leukemia	Stem Cell Exhaustion	A 44-year-old female developed a catastrophic thrombotic syndrome following allogeneic stem cell transplantation for acute lymphoblastic leukemia.	15753058
Coronary Arteriosclerosis, Ischemia, Diabetes Mellitus	Stem Cell Exhaustion	Transplantation of endothelial progenitor cells (EPCs) improves neovascularization after ischemia, but patients with coronary artery disease (CAD) or diabetes mellitus show a reduced number of EPCs and impaired functional activity.	15753227
Acute lymphocytic leukemia	Stem Cell Exhaustion	Reduced-intensity stem-cell transplantation for adult acute lymphoblastic leukemia: a retrospective study of 33 patients.	15756282
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	Efficacy of reduced-intensity stem-cell transplantation (RIST) for acute lymphoblastic leukemia (ALL) was investigated in 33 patients (median age, 55 years).	15756282
PAFAH1B1 wt Allele, leukemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disorder characterized by ineffective hematopoiesis and leukemia progression.	15759035
Harvesting of peripheral blood stem cells	Stem Cell Exhaustion	Patients received high-dose etoposide (2000 mg/m(2)) followed by peripheral blood stem cell harvest (PBSC).	15759115
Gastric Small Cell Carcinoma	Stem Cell Exhaustion	Therefore, this case raised the possibility that small cell gastric carcinoma may originate from totipotential stem cells of the stomach.	15762296
Pregnancy Complications, Infectious	Stem Cell Exhaustion	Low incidence of infectious complications after nonmyeloablative compared with myeloablative allogeneic stem cell transplantation.	15762935
Hematologic Neoplasms	Stem Cell Exhaustion	Fixed-dose single administration of Pegfilgrastim vs daily Filgrastim in patients with haematological malignancies undergoing autologous peripheral blood stem cell transplantation.	15765110
Hematologic Neoplasms	Stem Cell Exhaustion	To evaluate whether a single subcutaneous injection of pegfilgrastim (6 mg) is as safe and effective as daily filgrastim (5 mug/kg/day), 60 consecutive autologous stem cell transplantations performed for various haematological malignancies have been analysed.	15765110
Hematologic Neoplasms	Stem Cell Exhaustion	To decrease red blood cell (RBC) transfusion requirements during high-dose therapy (HDT) for hematological malignancies, we conducted a pilot study to assess the effect of recombinant human erythropoietin (rHuEpo) given during chemotherapy before HDT and autologous peripheral stem-cell transplantation (APSCT).	15765111
Communicable Diseases	Stem Cell Exhaustion	Peripheral T-cell expansion and low infection rate after reduced-intensity conditioning and allogeneic blood stem cell transplantation.	15765116
Toxic effect	Stem Cell Exhaustion	Peripheral blood stem cell transplantation after reduced-intensity conditioning (RIC-PBSCT) regimen is an alternative to conventional regimens with less immediate toxicity.	15765116
Acute myocardial infarction	Stem Cell Exhaustion	Stem-cell mobilization with G-CSF is a feasible and safe treatment for patients with revascularized acute myocardial infarction.	15766447
Primary malignant neoplasm	Stem Cell Exhaustion	Prospective, randomized comparison of high-dose chemotherapy with stem-cell support versus intermediate-dose chemotherapy after surgery and adjuvant chemotherapy in women with high-risk primary breast cancer: a report of CALGB 9082, SWOG 9114, and NCIC MA-13.	15767638
Childhood Breast Carcinoma	Stem Cell Exhaustion	Seven hundred eighty-five women aged 22 to 66 years with stage IIA, IIB, or IIIA breast cancer involving 10 or more axillary lymph nodes were randomized after surgery and standard adjuvant chemotherapy to either high-dose cyclophosphamide, cisplatin, and carmustine (HD-CPB) with stem-cell support or intermediate-dose cyclophosphamide, cisplatin, and carmustine (ID-CPB) with G-CSF support but without stem cells.	15767638
Primary malignant neoplasm	Stem Cell Exhaustion	HD-CPB with stem-cell support was not superior to ID-CPB for event-free or overall survival among all randomized women with high-risk primary breast cancer.	15767638
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Autologous peripheral blood stem cell transplantation is performed in an increasing number of chronic lymphocytic leukaemia (CLL) patients who are in the first remission following fludarabine treatment.	15770494
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Mobilization of peripheral blood stem cells in CLL patients after front-line fludarabine treatment.	15770494
Myositis, CTCAE 5.0, Chronic graft-versus-host disease	Stem Cell Exhaustion	Tc-99m MDP bone scintigraphy of myositis as a manifestation of chronic graft-versus-host disease after non-myeloablative peripheral stem cell transplantation.	15770972
Graft-vs-Host Disease, Chronic graft-versus-host disease, Polymyositis	Stem Cell Exhaustion	A 27-year-old man developed polymyositis as a manifestation of chronic graft-versus-host disease (GVHD) after non-myeloablative peripheral blood stem cell transplantation (PBSCT).	15770972
Atherosclerosis	Stem Cell Exhaustion	Accelerated atherosclerosis following intracoronary haematopoietic stem cell administration.	15772194
Cytomegalovirus Infections, Acute leukemia	Stem Cell Exhaustion	The value of CMV and fungal PCR for monitoring for acute leukaemia and autologous stem cell transplant patients.	15773033
Acute leukemia	Stem Cell Exhaustion	The aim of this prospective, blinded study was to use nucleic acid techniques for monitoring of 20 acute leukemia and 15 autologous stem cell transplant (SCT) patients.	15773033
Adult T-Cell Lymphoma/Leukemia	Stem Cell Exhaustion	Because T-ALLs derive from T-cell progenitors, expression profiles of the distinct T-ALL subgroups were analyzed with respect to those of normal human thymic subpopulations.	15774621
Alzheimers Disease	Stem Cell Exhaustion	Activating stem cells may treat Alzheimer's.	15774987
Hereditary Diseases	Stem Cell Exhaustion	Treatment with quinazolines may increase rAAV-2 transduction of keratinocyte stem cells, which is important for gene therapy approaches to inherited diseases.	15776248
Multiple Myeloma	Stem Cell Exhaustion	Prospective randomised trial of amifostine cytoprotection in myeloma patients undergoing high-dose melphalan conditioned autologous stem cell transplantation.	15778725
Gastrointestinal mucositis	Stem Cell Exhaustion	Factors influencing the incidence and severity of oral mucositis in patients undergoing autologous stem cell transplantation.	15779780
Gastrointestinal mucositis	Stem Cell Exhaustion	This retrospective descriptive study documented the frequency of oral mucositis and examined the impact of certain variables in the development of oral mucositis in autologous stem cell transplants.	15779780
Mantle cell lymphoma	Stem Cell Exhaustion	Hematopoietic stem cell transplantation in mantle cell lymphoma.	15781489
Medial collateral ligament	Stem Cell Exhaustion	The role of hematopoietic stem cell transplantation (HSCT) in MCL is unclear.	15781489
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The patient was treated with AML induction therapy followed by autologous stem cell transplantation, but relapse free survival was 6 months.	15786709
Type II Mucolipidosis, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukemia (AML) is considered a stem cell disease.	15788695
Childhood Breast Carcinoma, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The purpose of this study was to investigate the role of the breast cancer resistance protein (BCRP/ATP-binding cassette, subfamily G, member 2) in drug resistance of leukemic stem cells and the effect of its modulation on stem cell eradication in AML.	15788695
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Broad-spectrum inhibition, rather than modulation of single mechanisms, is therefore likely to be required to circumvent drug resistance and eradicate leukemic stem cells in AML.	15788695
Neoplasms	Stem Cell Exhaustion	This tumor may arise from the multipotential mesenchymal stem cells.	15796875
Osteopenia	Stem Cell Exhaustion	Prevention of bone loss after allogeneic stem cell transplantation by calcium, vitamin D, and sex hormone replacement with or without pamidronate.	15797959
Osteopenia	Stem Cell Exhaustion	In controlled studies, bisphosphonates have been used to prevent bone loss after solid organ transplantations but not in conjunction with stem cell transplantation (SCT).	15797959
Hepatitis B	Stem Cell Exhaustion	A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation.	15797991
Hepatic Complication, Hepatitis B	Stem Cell Exhaustion	The long-term hepatic complications after allogeneic hematopoietic stem cell transplantation (HSCT) in hepatitis B virus (HBV) endemic area are unknown.	15797991
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In this study, we sorted primary AML samples into stem cell-enriched CD34+/CD38- fractions and then analyzed the sorted and unsorted cells for the FLT3 mutant-wild-type ratio.	15797998
leukemia	Stem Cell Exhaustion	Internal tandem duplications of the FLT3 gene are present in leukemia stem cells.	15797998
FLT3 Internal Tandem Duplication	Stem Cell Exhaustion	As a final test of the importance of FLT3/ITD signaling in this engraftment model, we used a small molecule FLT3 inhibitor, CEP-701, to inhibit engraftment of FLT3/ITD stem cells.	15797998
leukemia	Stem Cell Exhaustion	Taken together, these experiments establish that the FLT3/ITD mutations are present in leukemia stem cells, and that FLT3 inhibitors may have activity against these cells.	15797998
Myopia	Stem Cell Exhaustion	Laser in situ keratomileusis treatment for myopia in a patient with partial limbal stem cell deficiency.	15798476
Contact lens overwear syndrome (disorder), Myopia	Stem Cell Exhaustion	The authors report a patient with soft contact lens-induced partial corneal limbal stem cell deficiency who successfully underwent laser in situ keratomileusis (LASIK) for correction of myopia.	15798476
Myopia	Stem Cell Exhaustion	In this patient with partial limbal stem cell deficiency secondary to soft contact lens wear, LASIK was a viable and safe alternative for the correction of myopia.	15798476
Coronary heart disease	Stem Cell Exhaustion	We report 2 cases in which patients with coronary heart disease not amenable for conventional revascularization underwent transmyocardial laser revascularization (TMLR) and implantation of AC133+ bone-marrow stem cells.	15799915
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Concurrent administration of high-dose rituximab before and after autologous stem-cell transplantation for relapsed aggressive B-cell non-Hodgkin's lymphomas.	15800314
Aggressive Non-Hodgkin Lymphoma, Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	We investigated the efficacy and safety of administering high-dose rituximab (HD-R) in combination with high-dose carmustine, cytarabine, etoposide, and melphalan chemotherapy and autologous stem-cell transplantation (SCT) in patients with recurrent B-cell aggressive non-Hodgkin's lymphoma (NHL).	15800314
HOX11 protein, Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement	Stem Cell Exhaustion	The 8p11 myeloproliferative syndrome (EMS) also known as stem cell leukemia-lymphoma syndrome (SCLL) is associated with translocations that disrupt FGFR1.	15800673
Cytomegalovirus Infections	Stem Cell Exhaustion	Significance of qualitative PCR detection method for preemptive therapy of cytomegalovirus infection in patients after allogeneic hematopoietic stem cell transplantation -- single-centre experience.	15800712
Mycoses	Stem Cell Exhaustion	Haemopoietic cell transplantation of patients with a history of deep or invasive fungal infection during prophylaxis with liposomal amphotericin B. Relapse of a preceding fungal infection is a considerable risk during haemopoietic stem cell transplantation.	15802888
Neutropenia, Congenital Abnormality	Stem Cell Exhaustion	In this study, the autonomous proliferation of bone marrow progenitor cells (CFU-C), a pathological phenomenon observed in many hematological abnormalities, was investigated in 31 individuals who had been diagnosed as having neutropenia.	15803866
Hippocampus (Brain), Epilepsy, GCD Regimen	Stem Cell Exhaustion	These findings support the view that GCD may be a phenomenon related to increased progenitor cell proliferation in patients with hippocampal damage and chronic epilepsy.	15804050
Graft-vs-Host Disease, Toxic effect	Stem Cell Exhaustion	Optimal initial dose of oral cyclosporine in relation to its toxicities for graft-versus-host disease prophylaxis following reduced-intensity stem cell transplantation in Japanese patients.	15806118
Toxic effect	Stem Cell Exhaustion	Melphalan 200 mg/m2 with blood stem cell support as first-line myeloma therapy: impact of glomerular filtration rate on engraftment, transplantation-related toxicity and survival.	15806125
Multiple Myeloma	Stem Cell Exhaustion	In this retrospective single-centre study, 96 consecutive myeloma patients were treated with melphalan 200 mg/m(2) with blood stem cell support as first-line therapy.	15806125
Toxic effect	Stem Cell Exhaustion	The impact of renal function on stem cell collection yield, engraftment, transplantation-related toxicity and overall survival was studied.	15806125
Fever, Pregnancy Complications, Infectious	Stem Cell Exhaustion	No relationship between GFR and stem cell collection yield or engraftment was observed, nor was the incidence of neutropenic fever or infectious complications related to GFR.	15806125
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Impact of disease burden at time of allogeneic stem cell transplantation in adults with acute myeloid leukemia and myelodysplastic syndromes.	15806131
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The impact of disease burden on the outcome of patients with acute myeloid leukemia (AML) undergoing allogeneic stem cell transplantation (SCT) has not been well defined.	15806131
Multiple Myeloma	Stem Cell Exhaustion	Pilot study of 13cis-retinoic acid+dexamethasone+alpha interferon as maintenance therapy following high-dose chemotherapy and autologous stem cell transplant for multiple myeloma.	15806132
Malignant - descriptor, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myelogenous leukemia (CML) is a malignant disorder of the hematopoietic stem cell characterized by the BCR-ABL oncogene.	15806158
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Distinct molecular phenotype of malignant CD34(+) hematopoietic stem and progenitor cells in chronic myelogenous leukemia.	15806158
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We examined gene expression profiles of highly enriched CD34(+) hematopoietic stem and progenitor cells from patients with CML in chronic phase using cDNA arrays covering 1.185 genes.	15806158
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Treatment of CML progenitor cells with the selective adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) resulted in a dose-dependent significant inhibition of clonogenic growth by 40% at a concentration of 10(-5) M, which could be reversed by the equimolar addition of the receptor agonist 2-chloro-N6-cyclopentyladenosine (P<0.05).	15806158
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The incubation of normal progenitor cells with DPCPX resulted in an inhibition of clonogenic growth to a significantly lesser extent in comparison with CML cells (P<0.05), suggesting that the adenosine A1 receptor is of functional relevance in CML hematopoietic progenitor cells.	15806158
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Impact of three courses of intensified CHOP prior to high-dose sequential therapy followed by autologous stem-cell transplantation as first-line treatment in poor-risk, aggressive non-hodgkin's lymphoma: comparative analysis of Dutch-Belgian Hemato-Oncology Cooperative Group Studies 27 and 40.	15809447
Aggressive Non-Hodgkin Lymphoma, Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	Timing, appropriate amount, and composition of treatment before high-dose therapy and autologous stem-cell transplantation (ASCT) in patients with poor-risk, aggressive non-Hodgkin's lymphoma (NHL) are still unknown.	15809447
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Allogeneic stem-cell transplantation may overcome the adverse prognosis of unmutated VH gene in patients with chronic lymphocytic leukemia.	15809449
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	To investigate whether allogeneic stem-cell transplantation (allo-SCT) may overcome the negative impact of unmutated VH genes in the outcome of patients with chronic lymphocytic leukemia (CLL).	15809449
Medullary carcinoma of thyroid	Stem Cell Exhaustion	A phase I trial combining high-dose 90Y-labeled humanized anti-CEA monoclonal antibody with doxorubicin and peripheral blood stem cell rescue in advanced medullary thyroid cancer.	15809485
Toxic effect, NTRK1 wt Allele, Medullary carcinoma of thyroid	Stem Cell Exhaustion	This trial determined the pharmacokinetics, dosimetry, and dose-limiting toxicity of 90Y-hMN-14 IgG (humanized anticarcinoembryonic antigen [CEA, or CEACAM5] monoclonal antibody; labetuzumab), combined with doxorubicin and peripheral blood stem cell (PBSC) support in advanced medullary thyroid cancer (MTC) patients.	15809485
Pregnancy Complications, Infectious, Lymphoproliferative Disorders	Stem Cell Exhaustion	Evaluation of potential risk factors for early infectious complications after autologous peripheral blood stem cell transplantation in patients with lymphoproliferative diseases.	15809882
Febrile Neutropenia	Stem Cell Exhaustion	A number of risk factors for the occurrence of neutropaenic fever after haematopoietic stem cell transplantation (HSCT) have been proposed.	15809882
Malignant Neoplasms	Stem Cell Exhaustion	The most common underlying conditions were hematopoietic stem-cell transplantation (101/398 [25%]), hematologic malignancy (101/398 [25%]), and solid-organ transplantation (109/398 [27%]).	15809925
Renal Insufficiency	Stem Cell Exhaustion	Despite increased risk for renal impairment in allogeneic hematopoietic stem-cell transplant recipients, only 17% of patients demonstrated end-of-therapy doubling of S-Cr levels, and the median change in CCr was -10 mL/min (range, -107 to 108 mL/min).	15809928
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	Our findings are in support of a selective growth advantage model of PNH assuming that damage to the GPI+ hematopoietic stem-cell (HSC) compartment leads to compensatory hyperproliferation of residual GPI- HSCs.	15811960
Acute GVH disease	Stem Cell Exhaustion	Increased gene expression of chemokine receptors is correlated with acute graft-versus-host disease after allogeneic stem cell transplantation.	15812393
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease (GVHD) is still a major complication after allogeneic stem cell transplantation.	15812393
Toxic effect	Stem Cell Exhaustion	Grade 3 or 4 nonhaematological toxicity was minimal and stem cell mobilisation was not inhibited.	15812553
Coronary heart disease	Stem Cell Exhaustion	[Changes of endothelial progenitor cells from peripheral blood in patients with coronary heart diseases].	15812892
Coronary heart disease	Stem Cell Exhaustion	To investigate alterations of endothelial progenitor cells (EPCs) from peripheral blood in patients with coronary heart diseases.	15812892
Zygomycosis, Hodgkin Disease	Stem Cell Exhaustion	Surgery and treatment with high-dose liposomal amphotericin B for eradication of craniofacial zygomycosis in a patient with Hodgkin's disease who had undergone allogeneic hematopoietic stem cell transplantation.	15815047
Zygomycosis, Hodgkin Disease	Stem Cell Exhaustion	This case report describes craniofacial zygomycosis in a 24-year-old male with Hodgkin's disease who underwent chemotherapy and autologous hematopoietic stem cell transplantation, followed by a nonmyeloablative allogeneic transplant.	15815047
Liver damage, Aplastic Anemia	Stem Cell Exhaustion	Immune-mediated stem cell damage has been postulated to be responsible for disease initiation and progression in aplastic anemia (AA).	15815907
Tumor necrosis	Stem Cell Exhaustion	It is hypothesized that T lymphocytes play a major role in destroying the bone marrow (BM) stem cells of AA patients by infiltrating the BM and secreting excessive levels of anti-hematopoietic cytokines, interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha).	15815907
Graft-vs-Host Disease	Stem Cell Exhaustion	Selective depletion of alloreactive donor lymphocytes: a novel method to reduce the severity of graft-versus-host disease in older patients undergoing matched sibling donor stem cell transplantation.	15817673
Pancreatic carcinoma	Stem Cell Exhaustion	Graft-versus-tumor effect against advanced pancreatic cancer after allogeneic reduced-intensity stem cell transplantation.	15818325
Pancreatic carcinoma	Stem Cell Exhaustion	The authors thus started a prospective study of allogeneic reduced-intensity hematopoietic stem cell transplantation (RIST) for patients with advanced pancreatic cancer to evaluate the feasibility and efficacy of this approach for such patients.	15818325
Lymphoma	Stem Cell Exhaustion	Long term hematologic recovery after autologous stem cell transplantation in lymphoma patients: impact of the number of prefreeze and post-thaw CD34+ cells.	15820915
Lymphoma	Stem Cell Exhaustion	Autologous Stem Cell Transplantation (ASCT) with Peripheral Blood Stem Cells is widely used as consolidation in lymphoma patients.	15820915
Stable chronic Graft vs Host Disease	Stem Cell Exhaustion	We examined chimerism in peripheral blood of 54 allogeneic stem cell recipients using multiplex STR-PCR method and compared it with the timing and severity of cGvHD.	15821766
Decreased platelet count	Stem Cell Exhaustion	Safety of low-dose low-molecular-weight-heparins in thrombocytopenic stem cell transplantation patients: a case series and review of the literature.	15821771
Pneumonia	Stem Cell Exhaustion	Surveillance of nosocomial sepsis and pneumonia in patients with a bone marrow or peripheral blood stem cell transplant: a multicenter project.	15824981
Neutropenia, Behavioral Symptoms Index Composite Score (BASC-2), Infection of bloodstream, Pneumonia	Stem Cell Exhaustion	For surveillance of nosocomial bloodstream infections (BSIs) and pneumonia during neutropenia in adult patients who have undergone bone marrow transplantation (BMT) or peripheral blood stem cell transplantation (PBSCT), a multicenter study--the Hospital Infection Surveillance System for Patients with Hematologic/Oncologic Malignancies (ONKO-KISS)--was initiated in Germany in 2000.	15824981
Diabetes	Stem Cell Exhaustion	As there is extensive ruin of the vascular bed due to diabetes, vascular regeneration therapy by stem cell implantation is effective.	15828908
Kidney Failure, Chronic, Diabetes, Arteriosclerosis Obliterans	Stem Cell Exhaustion	Thirty patients with ischemic limbs due to diabetes (not including type-I) and on dialysis for chronic renal failure (19 cases), diabetes (5 cases), dialysis patients without diabetes (4 cases), and arteriosclerosis obliterans (ASO, 2 cases) were treated by autologous peripheral blood stem cell (PBSC) implantation where imminent amputation was under consideration.	15828908
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Reduced-intensity conditioning lowers treatment-related mortality of allogeneic stem cell transplantation for chronic lymphocytic leukemia: a population-matched analysis.	15830011
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	To elucidate whether reduced-intensity conditioning (RIC) decreases treatment-related mortality (TRM) after allogeneic stem cell transplantation (allo-SCT) for chronic lymphocytic leukemia (CLL), we retrospectively compared 73 RIC cases from a recent EBMT survey with 82 patients from the EBMT database who had undergone standard myeloablative conditioning (MC) for CLL during the same time period.	15830011
beta Thalassemia	Stem Cell Exhaustion	The allogeneic hematopoietic stem cell transplantation is the only curative therapy for beta-thalassemia major.	15833187
Malignant Neoplasms	Stem Cell Exhaustion	Because they are long-lived and cycle continuously, adult stem cells (ASCs) are predicted as the most common precursor for cancers in adult mammalian tissues.	15833845
Hematologic Neoplasms	Stem Cell Exhaustion	Allogeneic hemopoietic stem cell transplantation (HSCT) is the only curative option for many patients with hematological malignancies.	15834432
BCR gene	Stem Cell Exhaustion	Autologous and allogeneic stem cell transplantation in adult ALL: the Swedish Adult ALL Group experience.	15834433
Chronic myocardial ischemia	Stem Cell Exhaustion	Effect of mobilization of bone marrow stem cells by granulocyte colony stimulating factor on clinical symptoms, left ventricular perfusion and function in patients with severe chronic ischemic heart disease.	15837093
Myocardial Ischemia	Stem Cell Exhaustion	A phase I safety and efficacy study with granulocyte colony stimulating factor (G-CSF) mobilization of bone marrow stem cells to induce vasculogenesis in patients with severe ischemic heart disease (IHD) was conducted.	15837093
Huntingtons Disease Pathway	Stem Cell Exhaustion	The distribution of progenitor cells in the subependymal layer of the lateral ventricle in the normal and Huntington's disease human brain.	15837138
Neurodegenerative Disorders, HD Term Type, "Huntingtons Disease Pathway	Stem Cell Exhaustion	The recent demonstration of endogenous stem/progenitor cells in the adult mammalian brain raises the exciting possibility that these undifferentiated cells may be able to generate new neurons for cell replacement in neurodegenerative diseases such as Huntington's disease (HD).	15837138
Huntingtons Disease Pathway	Stem Cell Exhaustion	There was a 2.6-fold increase in the number of new neurons that were produced in the Huntington's disease SEL compared with the normal SEL; however, the Huntington's disease SEL had many more proliferating progenitor cells; thus, the proportion of new neuron production relative to the number of progenitor cells was approximately the same.	15837138
B-Cell Lymphomas, Aggressive course	Stem Cell Exhaustion	Rituximab and CHOP in addition to chemotherapy may be an alternative treatment for aggressive recurrent, pediatric CD20-positive B-cell large cell non-Hodgkin's lymphoma if highly intensive chemotherapy and stem cell transplantation are not available.	15838396
Lower Extremity	Stem Cell Exhaustion	To observe the clinical efficacy of autologous peripheral blood stem cells (PBSC) transplantation in 62 cases with ischemic lower extremity disorder.	15840218
Spinal Cord Ischemia, Diabetic Foot	Stem Cell Exhaustion	Totally 62 patients with 34 cases of diabetic foot and 28 cases of various lower extremity ischemic disorders received recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) 450 - 600 microg/d by hypodermic injection for 5 days to mobilize stem cells.	15840218
Cerebral Infarction, Diabetic Foot	Stem Cell Exhaustion	No related complication or adverse effect was observed except in 2 patients with diabetic foot and cerebral infarction exacerbation of symptoms during the process of stem cells mobilization in all process.	15840218
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Moreover, IC87114 inhibited AML cell proliferation without affecting the proliferation of normal hematopoietic progenitor cells.	15840695
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	One versus two high-dose cytarabine-based consolidation before autologous stem cell transplantation for young acute myeloblastic leukaemia patients in first complete remission.	15842665
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We report on a randomized trial aimed to determine the impact of a second consolidative high-dose cytarabine-based chemotherapy (HiDAC) in patients with acute myeloid leukaemia prior to an autologous stem cell transplantation (ASCT).	15842665
Pancreatic carcinoma, Stem Cell Factor, Pancreatitis, Chronic	Stem Cell Exhaustion	Therefore, in the present study, we investigated in pancreatic cancer patients the serum levels of selected HCs, such as stem cell factor (SCF), interleukin 3 (IL-3), granulocyte-macrophage-colony stimulating factor (GM-CSF), granulocyte-colony stimulating factor (G-CSF) and macrophage-colony stimulating factor (M-CSF) in relation to a control group and to a group of patients with chronic pancreatitis.	15843207
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The role of reduced intensity conditioning allogeneic stem cell transplantation in patients with acute myeloid leukemia: a donor vs no donor comparison.	15843817
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Using a genetic randomization through a 'donor' vs 'no donor' comparison, the aim of this analysis was to assess the real benefit of reduced intensity conditioning allogeneic stem cell transplantation (RIC-allo-SCT) among 95 adult high-risk acute myeloid leukemia (AML) patients.	15843817
bone marrow fibrosis, Primary Myelofibrosis	Stem Cell Exhaustion	Agnogenic myeloid metaplasia (AMM) is a clonal stem cell disorder that leads to ineffective hematopoiesis, bone marrow fibrosis, and extramedullary hematopoiesis.	15849170
Primary Myelofibrosis	Stem Cell Exhaustion	Detection of aberrant gene expression in CD34+ hematopoietic stem cells from patients with agnogenic myeloid metaplasia using oligonucleotide microarrays.	15849170
Liver Failure, Damage, Hepatitis A	Stem Cell Exhaustion	[Clinical and experimental study of the therapeutic effect of umbilical cord blood stem cell transplantation on liver failure and heart damage in severe viral hepatitis patients].	15850511
Liver Failure, Damage, Lesion of liver	Stem Cell Exhaustion	To investigate and compare the therapeutic effect of umbilical cord blood stem cell transplantation (UCBSCT) or adult fresh plasma in severe viral hepatitis liver failure with/without heart damage, and to study the effect of UCBSCT on liver lesions in rats.	15850511
Liver damage	Stem Cell Exhaustion	The rat liver immunohistochemistry indicated that neonate cord blood stem cell application can decrease the liver damage and increase hepatocellular regeneration.	15850511
Globoid cell leukodystrophy	Stem Cell Exhaustion	Hematopoietic stem cell transplantation has proven to have a positive effect on the course of some patients with late-onset Krabbe disease.	15851012
Bronchiolitis Obliterans	Stem Cell Exhaustion	Lower incidence of Bronchiolitis obliterans in allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning compared with myeloablative conditioning.	15852024
Bronchiolitis Obliterans, bottle - unit dose	Stem Cell Exhaustion	Bronchiolitis obliterans (BO) is one of the most devastating complications after allogeneic stem cell transplantation (HSCT).	15852024
Peripheral arterial occlusive disease, Ischemia	Stem Cell Exhaustion	Therapeutical potential of blood-derived progenitor cells in patients with peripheral arterial occlusive disease and critical limb ischaemia.	15855189
Ischemia	Stem Cell Exhaustion	Recent evidence from animal models of hind limb ischaemia suggests that neovascularization induced by circulating blood-derived progenitor cells (CPCs) may permit limb salvage.	15855189
Anemia, Rhesus Hemolytic Disease of the Newborn, Reticulocytopenia, Hemolysis (biological function)	Stem Cell Exhaustion	Our findings (reticulocytopenia and normal bilirubin levels) support the hypothesis that the pathogenesis of anaemia and haemolysis in anti-k HDN may be similar to that in anti-K (suppression of erythropoesis and immune destruction of K+ erythroid progenitor cells by macrophages in the foetal liver).	15859984
Pneumonia, Bacterial	Stem Cell Exhaustion	Increased circulating endothelial progenitor cells in patients with bacterial pneumonia: evidence that bone marrow derived cells contribute to lung repair.	15860717
Lung Injury	Stem Cell Exhaustion	It has been shown that administration of lipopolysaccharide (LPS) to murine lungs induces a rapid release of endothelial progenitor cells (EPCs) into the circulation, and that bone marrow derived progenitor cells including EPCs contribute to lung repair after lung injury in mice.	15860717
Endothelial dysfunction	Stem Cell Exhaustion	Impaired progenitor cell activity in age-related endothelial dysfunction.	15862416
Endothelial dysfunction	Stem Cell Exhaustion	We investigated whether human age-related endothelial dysfunction is accompanied by quantitative and qualitative alterations of the endothelial progenitor cell (EPC) pool.	15862416
Peripheral vascular complication, Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus.	15862417
Peripheral Vascular Diseases, Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	We sought to establish whether a reduction in endothelial progenitor cells (EPCs) has a putative role in peripheral vascular disease (PVD) of type 2 diabetic patients.	15862417
Specialty Type - cancer	Stem Cell Exhaustion	The aim of this study was to examine cognitive performance in patients prior to bone marrow or haematopoietic stem cell transplantation (SCT) and in haematological patients who received non-myeloablative cancer therapies.	15862749
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Based on the activity of menadione (M) in the human tumor stem cell assay, we conducted a phase I trial of M in patients with advanced cancer.	15868379
Small cell carcinoma of lung	Stem Cell Exhaustion	We carried out a phase III randomized trial in patients with better-prognosis SCLC (i.e., prognostic score of 0-1) to investigate whether doubling the dose density of ifosfamide, carboplatin, and etoposide (ICE) chemotherapy with filgrastim and blood-progenitor-cell support improves survival, compared with standard ICE chemotherapy.	15870437
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Intensive treatment and stem cell transplantation in chronic myelogenous leukemia: long-term follow-up.	15870485
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	In the present study we combined interferon (IFN) and hydroxyurea (HU) treatment, intensive chemotherapy and autologous stem cell transplantation (SCT) in newly diagnosed chronic myelogenous leukemia patients aged below 56 years, not eligible for allogeneic SCT.	15870485
Meningitis	Stem Cell Exhaustion	Meningitis is a rare complication following organ and stem-cell transplantation and can be caused by a variety of microorganisms.	15875764
Listeriosis	Stem Cell Exhaustion	To retrospectively review the clinical course and outcome of five cases of listeriosis in four organ recipients and one stem-cell recipient during a seven-year period.	15875764
Huntingtons Disease Pathway	Stem Cell Exhaustion	Paradoxically, an increase in ATF2 expression was found in the subependymal layer of Huntington's disease cases, compared with normal brains; a region reported to contain increased numbers of proliferating progenitor cells in Huntington's disease.	15878807
Myeloid Progenitor Cells	Stem Cell Exhaustion	Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.	15879151
Multiple Myeloma	Stem Cell Exhaustion	Extent of damage and repair in the p53 tumor-suppressor gene after treatment of myeloma patients with high-dose melphalan and autologous blood stem-cell transplantation is individualized and may predict clinical outcome.	15883412
Coronary Arteriosclerosis	Stem Cell Exhaustion	Sixteen patients with de novo coronary artery disease were successfully treated with implantation of endothelial progenitor cell (EPC) capture stents.	15893169
Respiratory Failure	Stem Cell Exhaustion	Pretransplant lung function, respiratory failure, and mortality after stem cell transplantation.	15894602
Respiratory Failure	Stem Cell Exhaustion	The role of pulmonary function before stem cell transplant as a potential risk factor for the development of early post-transplant respiratory failure and mortality is controversial.	15894602
Hematopoietic stem cells, Fibrosis Assessment	Stem Cell Exhaustion	These findings suggest that the BM fibrosis and abnormal hematopoietic stem cell distribution in patients with IM is a consequence of the progeny of a malignant hematopoietic stem cell clone.	15899773
Granulomatosis with polyangiitis	Stem Cell Exhaustion	Membrane proteinase 3 expression in patients with Wegener's granulomatosis and in human hematopoietic stem cell-derived neutrophils.	15901769
Dermatomyositis, Pneumonia, Interstitial	Stem Cell Exhaustion	Successful treatment of rapidly progressive interstitial pneumonia with autologous peripheral blood stem cell transplantation in a patient with dermatomyositis.	15902522
Dermatomyositis, Pneumonia, Interstitial	Stem Cell Exhaustion	We describe a 54-year-old female patient with rapidly progressive and refractory interstitial pneumonia due to dermatomyositis, which was successfully treated with high-dose cyclophosphamide and autologous blood stem cell transplantation.	15902522
Diabetic Retinopathy	Stem Cell Exhaustion	Thus, we evaluate the concentrations of circulating endothelial progenitor cells (EPCs) and stem cell modulation factors such as vascular endothelial growth factor (VEGF), erythropoietin (Epo), and substance p (SP) in the peripheral blood of diabetic retinopathy patients.	15905870
Diabetic Retinopathy	Stem Cell Exhaustion	Involvement of circulating endothelial progenitor cells and vasculogenic factors in the pathogenesis of diabetic retinopathy.	15905870
Neoplasms	Stem Cell Exhaustion	Solid tumors after hematopoietic stem cell transplantation in Japan: incidence, risk factors and prognosis.	15908969
Neoplasms	Stem Cell Exhaustion	To evaluate the incidence, risk factors and prognosis for solid tumors after hematopoietic stem cell transplantation (HSCT) in Japan, 809 patients who had received HSCT between 1981 and 2000 were retrospectively analyzed.	15908969
Omenn Syndrome	Stem Cell Exhaustion	Hematopoietic stem cell transplantation in Omenn syndrome: a single-center experience.	15908971
Omenn Syndrome	Stem Cell Exhaustion	We retrospectively analyzed the outcome of hematopoietic stem cell transplantations (HSCT) performed at our Center between 1991 and 2002 in 11 unselected patients with Omenn syndrome, a variant of severe combined immunodeficiency.	15908971
Bacterial Infections	Stem Cell Exhaustion	Prophylaxis of early bacterial infections after autologous peripheral blood stem cell transplantation (PBSCT): a matched-pair study comparing oral fluoroquinolones and intravenous piperacillin-tazobactam.	15908979
Bacillus cereus	Stem Cell Exhaustion	Successful treatment of Bacillus cereus meningitis following allogenic stem cell transplantation.	15910391
Hodgkin Disease	Stem Cell Exhaustion	We report the case of a 19-yr-old boy, who received an allogeneic stem cell transplantation for the second relapse of Hodgkin's disease.	15910391
Graft-vs-Host Disease	Stem Cell Exhaustion	For recipients of haploidentically mismatched stem cell allografts, T-cell depletion is mandatory to prevent lethal graft-vs-host disease (GVHD).	15911096
Peripheral Blood Stem Cells, Hematologic Neoplasms	Stem Cell Exhaustion	Five patients with high-risk hematological malignancies, ages 7 to 63 years old (median, 17 years), underwent peripheral blood stem cell transplantation from haploidentically mismatched related donors.	15911096
Graft-vs-Host Disease	Stem Cell Exhaustion	Prevention of GVHD can be accomplished by negative selection of T cells or positive selection of stem cells.	15911096
Immature Myeloid Cell	Stem Cell Exhaustion	However, the immature myeloma cells were reduced by high-dose melphalan (HD-Mel) therapy followed by autologous stem cell transplantation (ASCT).	15914366
Hematopoietic Neoplasms	Stem Cell Exhaustion	Common 4q24 deletion in four cases of hematopoietic malignancy: early stem cell involvement?	15920487
Peripheral	Stem Cell Exhaustion	In three cases, we concluded that rearrangement occurred in an early hematopoietic stem cell, as it was detected, in mosaic with a normal karyotype, in a fraction of remission bone marrow cells, peripheral T and B lymphocytes, malignant lymph node T-lymphoma cells in one case and B-lymphoblastoid cell lines established in two cases.	15920487
Endocrine System Diseases	Stem Cell Exhaustion	Endocrine disorders during the first year after autologous stem-cell transplant.	15922699
Endocrine System Diseases	Stem Cell Exhaustion	Frequent endocrine disorders have been reported after allogeneic stem-cell transplant, but data on adult survivors of autologous transplants are still scarce.	15922699
Endocrine function	Stem Cell Exhaustion	In this prospective study we investigated early (at 3 months) and late (at 12 months) endocrine dysfunctions in 95 consecutive autologous stem-cell transplant recipients (47 men and 48 women) aged 16 to 55 years.	15922699
Endocrine System Diseases	Stem Cell Exhaustion	This study documents frequent endocrine disorders during the first year after autologous stem-cell transplant.	15922699
Liver carcinoma, Hollings Cancer Center	Stem Cell Exhaustion	Progenitor cells, termed oval cells, are involved in the pathogenesis of hepatocellular carcinoma (HCC) in animal models.	15923163
Lymphoma	Stem Cell Exhaustion	IIVP salvage regimen induces high response rates in patients with relapsed lymphoma before autologous stem cell transplantation.	15923799
Lymphoma	Stem Cell Exhaustion	Patients with relapsed lymphoma can be cured with high-dose chemotherapy and autologous hematopoietic stem cell transplantation (HSCT).	15923799
Childhood Breast Carcinoma	Stem Cell Exhaustion	High-dose chemotherapy and autologous stem cell rescue for metastatic breast cancer: superior survival for tandem compared with single transplants.	15923802
Childhood Breast Carcinoma	Stem Cell Exhaustion	During 1990-1999, we treated 60 patients with breast cancer who had distant metastases with high-dose chemotherapy and autologous stem cell rescue (HDC) after they had responded to induction chemotherapy.	15923802
Cerebrovascular accident	Stem Cell Exhaustion	Autologous mesenchymal stem cell transplantation in stroke patients.	15929052
Ischemic stroke	Stem Cell Exhaustion	Mesenchymal stem cell (MSC) transplantation improves recovery from ischemic stroke in animals.	15929052
leukemia	Stem Cell Exhaustion	Ethnicity variables in the incidence rates of leukemias in New Zealand populations: implications for stem-cell transplantation.	15929115
Specialty Type - cancer, leukemia	Stem Cell Exhaustion	We examined 10 years of data (1993-2002) from the New Zealand Cancer Registry to determine if there are ethnic differences in leukemia incidence in New Zealand, and we relate this to availability of stem-cell transplantation.	15929115
Leukemia, Myelocytic, Acute, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We conclude that, among New Zealand Maori and New Zealand Pacific Islanders, there is an increased risk of acute myeloid leukemia and chronic myeloid leukemia in age groups suitable for stem-cell transplantation.	15929115
Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease is a common complication after allogeneic stem cell transplantation.	15929116
How Often Shortness of Breath, Pulmonary Infiltrate, Coughing, infectious - Entity Risk	Stem Cell Exhaustion	We report a 54-year-old male who developed shortness of breath, cough, and bilateral pulmonary infiltrates in which the work-up failed to demonstrate an infectious etiology 165 days post-HLA-matched allogeneic peripheral blood stem cell transplant.	15929116
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease of the lung is a very uncommon complication after stem cell transplant, but it should be considered in patients who are at high risk for graft-versus-host disease or developing symptoms soon after discontinuing immunosuppression.	15929116
Infection of bloodstream	Stem Cell Exhaustion	Bloodstream infection after umbilical cord blood transplantation using reduced-intensity stem cell transplantation for adult patients.	15931631
Myeloid Leukemia	Stem Cell Exhaustion	Reduced-intensity conditioning allogeneic blood stem cell transplantation with fludarabine and oral busulfan with or without pharmacokinetically targeted busulfan dosing in patients with myeloid leukemia ineligible for conventional conditioning.	15931632
Neoplasms	Stem Cell Exhaustion	Tumor vaccine after high-dose chemotherapy (HDC) and autologous stem cell transplantation (ASCT) aims at directing immune recovery toward tumor responses after optimizing minimal residual disease.	15931636
Childhood Breast Carcinoma	Stem Cell Exhaustion	Establishing a platform for immunotherapy: clinical outcome and study of immune reconstitution after high-dose chemotherapy with progenitor cell support in breast cancer patients.	15931636
Infarction	Stem Cell Exhaustion	In this study, we tested whether the human heart possesses a cardiac stem cell (CSC) pool that promotes regeneration after infarction.	15932947
Heart failure	Stem Cell Exhaustion	Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure.	15932947
Therapy-Related Acute Myeloid Leukemia, Chromosome Aberrations	Stem Cell Exhaustion	Seventeen patients had developed t-AML after autologous stem cell transplantation, but no unique pattern of cytogenetic abnormalities was observed.	15935816
Therapy-Related Acute Myeloid Leukemia	Stem Cell Exhaustion	To gain insights into the molecular basis of this disease, we performed gene expression profiling of CD34+ hematopoietic progenitor cells from t-AML patients.	15935816
Pulmonary Complication	Stem Cell Exhaustion	Infectious pulmonary complications after stem cell transplantation or chemotherapy: diagnostic yield of bronchoalveolar lavage.	15936168
Pulmonary Complication	Stem Cell Exhaustion	Hematologic patients are at high risk for infectious pulmonary complications after stem cell transplantation (SCT) or chemotherapy.	15936168
Lymphoma	Stem Cell Exhaustion	Reduced-intensity hematopoietic stem-cell transplantation for malignant lymphoma: a retrospective survey of 112 adult patients in Japan.	15937505
Disease	Stem Cell Exhaustion	A total of 40 patients (36%) had relapsed diseases after autologous stem cell transplantation and 36 patients (32%) had received radiotherapy.	15937505
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Disease burden may identify patients more likely to benefit from second allogeneic hematopoietic stem cell transplantation to treat relapsed acute myelogenous leukemia.	15937511
Failure, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The major cause of failure after allogeneic hematopoietic stem cell transplantation (HSCT) for acute myelogenous leukemia (AML) is disease relapse or progression.	15937511
T-Cell Prolymphocytic Leukemia, Kidney Failure, Acute, Hemolysis (biological function)	Stem Cell Exhaustion	Nonmyeloablative peripheral blood stem cell transplant for T-cell prolymphocytic leukaemia complicated by fulminant haemolysis and acute renal failure at engraftment secondary to minor ABO incompatibility.	15938729
T-Cell Prolymphocytic Leukemia	Stem Cell Exhaustion	We present a 54-year-old man who underwent human leucocyte antigen-identical sibling nonmyeloablative peripheral blood stem cell transplant for primary refractory T-cell prolymphocytic leukaemia (T-PLL).	15938729
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study.	15939712
Adenomatous Polyposis Coli	Stem Cell Exhaustion	Stability of colon stem cell methylation after neo-adjuvant therapy in a patient with attenuated familial adenomatous polyposis.	15941485
Lymphoma	Stem Cell Exhaustion	Successful reduced-intensity stem cell transplantation (RIST) for a patient with malignant lymphoma and an ileostomy.	15942098
Amyloidosis	Stem Cell Exhaustion	Living donor kidney and autologous stem cell transplantation for primary systemic amyloidosis (AL) with predominant renal involvement.	15943624
Kidney Failure, Chronic	Stem Cell Exhaustion	Autologous stem cell transplantation (SCT) for AL achieves superior response rates compared to chemotherapy alone but patients with end-stage renal disease (ESRD) may be excluded from consideration.	15943624
Kidney Failure, Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation in multiple myeloma: outcome in patients with renal failure.	15946307
Kidney Failure, Multiple Myeloma	Stem Cell Exhaustion	The impact of renal failure on prognosis of multiple myeloma patients treated with high-dose chemotherapy and stem cell support is incompletely studied.	15946307
Hemoptysis, Coughing	Stem Cell Exhaustion	The 42-year-old patient presented with coughing and hemoptysis as major clinical signs 1 yr after successful HLA-identical stem cell transplantation.	15946314
Childhood Breast Carcinoma	Stem Cell Exhaustion	High-dose mitoxantrone-vinblastine-cyclophosphamide and autologous stem cell transplantation for stage III breast cancer: final results of a prospective multicentre study.	15946980
Lymphoma, leukemia	Stem Cell Exhaustion	A total of 100 thoracentesis findings were analyzed in patients with lymphoma (52 patients) and leukemia (27 patients), and in patients who had undergone bone marrow or stem cell transplantation (21 patients).	15947326
Hematological Disease	Stem Cell Exhaustion	To evaluate the use of a new reduced intensity of BuCy conditioning regimen for the treatment of malignant hematologic diseases in aged or intolerable patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT) from the siblings.	15949287
Muscular Dystrophy, Duchenne	Stem Cell Exhaustion	[Allogeneic umbilical cord blood stem cell transplantation in Duchenne muscular dystrophy].	15949330
Muscular Dystrophy, Duchenne	Stem Cell Exhaustion	To study the feasibility of treatment of Duchenne muscular dystrophy (DMD) with umbilical cord stem cell transplantation.	15949330
Graft-vs-Host Disease	Stem Cell Exhaustion	Umbilical cord stem cell transplantation helps re-build blood-making function, and improve locomotive function with a mild GVHD reaction.	15949330
Infection	Stem Cell Exhaustion	Those infections have long time been considered as a contraindication for subsequent haematopoietic stem cell transplantation (HCT).	15951986
Acute lymphocytic leukemia	Stem Cell Exhaustion	A 10-year-old boy with acute lymphoblastic leukemia in second relapse received CD34+ purified allogeneic peripheral blood stem cell transplantation (PBSCT) from his HLA-haploidentical father.	15952301
Adenovirus Infections, Thrombotic Microangiopathies	Stem Cell Exhaustion	Fatal adenovirus infection indistinguishable from thrombotic microangiopathy after allogeneic CD34+ peripheral progenitor cell transplantation.	15952301
Acute leukemia	Stem Cell Exhaustion	Outcomes of patients with acute leukaemia who relapsed after reduced-intensity stem cell transplantation from HLA-identical or one antigen-mismatched related donors.	15953007
Pre-Eclampsia	Stem Cell Exhaustion	Decrease and senescence of endothelial progenitor cells in patients with preeclampsia.	15956081
Pre-Eclampsia	Stem Cell Exhaustion	We hypothesized that cellular function of circulating endothelial progenitor cells (EPCs) might be impaired in patients with preeclampsia.	15956081
Ischemia	Stem Cell Exhaustion	Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes: results of 3 randomized studies.	15956121
Aplastic Anemia	Stem Cell Exhaustion	T-cell suppression mediated by mesenchymal stem cells is deficient in patients with severe aplastic anemia.	15963858
Aplastic Anemia	Stem Cell Exhaustion	To compare the suppressive effect of mesenchymal stem cells (MSC), derived from normal individuals or severe aplastic anemia patients (SAA), on T-cell activation.	15963858
Pterygia	Stem Cell Exhaustion	Fibrin sealant was used as the only technique of stem cell adhesion for limbal reconstruction for primary or recurrent pterygia and various stem cell-deficient diseases from 2000 to 2004.	15968167
Pterygia	Stem Cell Exhaustion	Miscellaneous stem cell deficiencies were included to demonstrate that corneal stem cell transplants can be used in other corneal procedures in addition to pterygia.	15968167
Myocardial Ischemia	Stem Cell Exhaustion	Current stem cell protocols for ischemic heart disease are limited by the small numbers of cells that can be obtained by bone marrow aspirate.	15970342
Chronic myocardial ischemia	Stem Cell Exhaustion	Intra-coronary high-dose CD34+ stem cells in patients with chronic ischemic heart disease: a 12-month follow-up.	15970342
Chronic myocardial ischemia	Stem Cell Exhaustion	To increase myocardial delivery of bone marrow stem cells in patients with chronic ischemic heart disease (CIHD), we used granulocyte colony stimulating factor (G-CSF) for bone marrow mobilization of CD34+ cells, enabling intracoronary infusion of large numbers of CD34+ stem cells.	15970342
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	To examine how killer-cell immunoglobulin-like receptor (KIR) ligand incompatibilities effect molecular relapse (MR), we compared the occurrence of bcr-abl-positive reverse-transcriptase polymerase chain reaction (RT-PCR) results in 236 CML patients (pts) after human leukocyte antigen (HLA)-identical (n=158) (group 1), HLA class I antigen mismatched and KIR-ligand compatible (n=49) (group 2), and HLA class I antigen mismatched and KIR-ligand incompatible (n=29) (group 3) hematopoietic stem-cell transplantation.	15973179
Atherosclerosis	Stem Cell Exhaustion	Endothelial progenitor cell therapy for atherosclerosis: the philosopher's stone for an aging population?	15975898
Cardiovascular Diseases, Atherosclerosis, Cyclophosphamide/Vincristine/Dacarbazine Regimen	Stem Cell Exhaustion	To estimate the impact of progenitor cell therapy for atherosclerosis on cardiovascular disease (CVD) mortality, life expectancy, and survival, as compared with the lifetime control of conventional risk factors, we modeled the health effects of bone marrow-derived endothelial progenitor cell therapy using data from the 1950 to 1996 follow-up of the Framingham Heart Study.	15975898
Cardiovascular Diseases, Atherosclerosis	Stem Cell Exhaustion	To model cardiovascular disease mortality, we assumed that progenitor cell therapy was applied at age 30, with the effect assumed to be a 10-year delay in atherosclerosis progression.	15975898
Specialty Type - cancer	Stem Cell Exhaustion	We considered three types of interventions: (i) keeping risk factors within selected limits to model current clinical recommendations; (ii) an age shift of 10 years to model the effects of progenitor cell therapy; and (iii) elimination of a competing risk (such as cancer).	15975898
Specialty Type - cancer	Stem Cell Exhaustion	Our study suggests that progenitor cell therapy might increase life expectancy in the population as much as the complete elimination of cancer (in females, an additional 3.67 versus 3.37 years; in males, an additional 5.94 versus 2.86 years, respectively).	15975898
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	This study evaluates the prognostic value of molecular monitoring of minimal residual disease (MRD) in 20 patients with multiple myeloma (MM) following autologous (peripheral blood stem cell transplantation, PBSCT) and non-myeloablative allogeneic (NMT) transplant.	15978948
Angiolymphoid hyperplasia	Stem Cell Exhaustion	Successful hematopoietic stem-cell transplantation in multicentric Castleman disease complicated by POEMS syndrome.	15981232
Angiolymphoid hyperplasia	Stem Cell Exhaustion	A diagnosis of multicentric Castleman disease with POEMS syndrome was made, and he then received high-dose chemotherapy with melphalan followed by autologous peripheral blood stem-cell transplantation.	15981232
Angiolymphoid hyperplasia	Stem Cell Exhaustion	Hematopoietic stem-cell transplantation may be a treatment option for patients with multicentric Castleman disease and POEMS syndrome.	15981232
PAFAH1B1 wt Allele	Stem Cell Exhaustion	These results indicate that CD34(+) cell selection is required to accurately assess the expression levels of HOXA9 and related genes in the multipotential malignant progenitor cells of MDS patients.	15982348
Aspergillosis	Stem Cell Exhaustion	Chest computed tomography of late invasive aspergillosis after allogeneic hematopoietic stem cell transplantation.	15983550
Aspergillosis	Stem Cell Exhaustion	Computed tomography (CT) is a powerful diagnostic tool for invasive aspergillosis (IA) after allogeneic stem cell transplantation (allo-SCT); however, little information is available concerning CT findings of late IA after allo-SCT.	15983550
Lymphoma	Stem Cell Exhaustion	PV701 mouthwash (15 mL x 13.5 mg/mL) was administered 6 times a day for 12 days, from day--6 to day +5, to patients with lymphoma, who were given BEAM on day--6 to day--2, with autologous stem cells infused on day 0.	15983551
Toxic effect, Pneumocystis jiroveci	Stem Cell Exhaustion	Toxicity and efficacy of daily dapsone as Pneumocystis jiroveci prophylaxis after hematopoietic stem cell transplantation: a case-control study.	15983552
Toxic effect, Phencyclidine, Pneumocystis jiroveci	Stem Cell Exhaustion	The toxicity and efficacy of dapsone given daily as Pneumocystis jiroveci (PCP) prophylaxis in hematopoietic stem cell transplant (HSCT) recipients who cannot take trimethoprim-sulfamethoxazole (TMP-SMX) have not been fully evaluated.	15983552
Engraftment syndrome	Stem Cell Exhaustion	Engraftment syndrome after nonmyeloablative allogeneic hematopoietic stem cell transplantation: incidence and effects on survival.	15983554
Engraftment syndrome	Stem Cell Exhaustion	Engraftment syndrome (ES) encompasses a constellation of symptoms that occur during neutrophil recovery after both autologous and allogeneic hematopoietic stem cell transplantation (HCT).	15983554
Multiple Myeloma	Stem Cell Exhaustion	Localized extramedullary relapse after autologous hematopoietic stem cell transplantation in multiple myeloma.	15983690
Plasmacytoma - category	Stem Cell Exhaustion	After hematopoietic stem cell transplantation HSCT, presentation of localized plasmacytoma with extramedullary growth is very unusual.	15983690
Infection of bloodstream	Stem Cell Exhaustion	Pre- and post-engraftment bloodstream infection rates and associated mortality in allogeneic hematopoietic stem cell transplant recipients.	15984943
Infection of bloodstream	Stem Cell Exhaustion	We report on bloodstream infection (BSI) rates, risk factors, and outcome in a cohort of 298 adult and pediatric hematopoietic stem cell transplantation (HSCT) recipients at Memorial Sloan-Kettering Hospital from September 1999 through June 2003.	15984943
Neutropenia, Acute GVH disease, Abnormal renal function, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	In multivariate analyses, pre-engraftment BSI was associated with diagnosis of chronic myelogenous leukemia, age >18 years and peripheral blood stem cell graft; post-engraftment BSI was associated with acute graft-versus-host disease, neutropenia, and liver or kidney dysfunction.	15984943
Colorectal Carcinoma	Stem Cell Exhaustion	Stem cell factor (SCF) and interleukin 3 (IL-3) in the sera of patients with colorectal cancer.	15986847
Colorectal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	These factors take part in the regulation of developmental processes of hematopoietic progenitor cells and it was proved that HCs can be produced by different cancer cells, including colorectal cancer.	15986847
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder characterized by the balanced reciprocal translocation t (9:22).	15987013
Psoriatic Juvenile Idiopathic Arthritis, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Severe vulgaris psoriatic patients with acute myelogenous leukaemia and resolution after allogeneic bone marrow transplantation/peripheral blood stem cell transplantation.	15989770
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	A 10-year median follow-up study after allogeneic stem cell transplantation for chronic myeloid leukemia in chronic phase from HLA-identical sibling donors.	15990868
Specialty Type - cancer	Stem Cell Exhaustion	National estimates of the use of hematopoietic stem-cell transplantation in children with cancer in the United States.	15995713
Malignant Neoplasms	Stem Cell Exhaustion	National utilization data for hematopoietic stem-cell transplantation (HSCT) for childhood cancers in the United States have not been reported.	15995713
Specialty Type - cancer	Stem Cell Exhaustion	We compared patient, hospital, and resource use characteristics and in-patient mortality associated with HSCT and non-HSCT encounters, estimated the number of HSCT encounters by stem-cell source and cancer type, and examined resource use and mortality in each category.	15995713
Specialty Type - cancer	Stem Cell Exhaustion	There was wide variation in resource use and mortality by stem-cell source and cancer type.	15995713
Myeloproliferative disease	Stem Cell Exhaustion	Progenitor cell trafficking in physiologic conditions and in myeloproliferative diseases: quantification of CD34+ cells by polymerase chain reaction.	15996924
leukemia	Stem Cell Exhaustion	Development of leukemia in donor cells after allogeneic stem cell transplantation--a survey of the European Group for Blood and Marrow Transplantation (EBMT).	15996934
leukemia	Stem Cell Exhaustion	Leukemia in donor cells (donor cell leukemia; DCL) has been reported as a rare but severe complication of allogeneic stem cell transplantation (SCT).	15996934
Hematologic Neoplasms	Stem Cell Exhaustion	None of the stem cell donors developed hematologic malignancies (median follow-up period of 9 years; range 6-30 years).	15996934
Hematologic Neoplasms	Stem Cell Exhaustion	Complete and partial responses were recorded in 35% of patients and varied by the underlying disease group: hematologic malignancies (54%), other underlying conditions (50%), chronic immunosuppression (45%), solid organ transplantation (36%), and hematopoietic stem cell transplantation (16%).	15998833
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	This study reports outcomes of allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning (RIC) in 186 patients with chronic myeloid leukemia (CML) from the European Group for Blood and Marrow Transplantation (EBMT).	15998838
Bronchiolitis Obliterans, leukemia	Stem Cell Exhaustion	Risk factors for bronchiolitis obliterans in allogeneic hematopoietic stem-cell transplantation for leukemia.	16002929
Bronchiolitis Obliterans	Stem Cell Exhaustion	Reported risk factors for bronchiolitis obliterans (BO) in allogeneic hematopoietic stem-cell transplant recipients come from modest-sized studies and are limited to experiences of single institutions.	16002929
Graft-vs-Host Disease, Pneumonia, Interstitial	Stem Cell Exhaustion	On multivariate analysis, the factors that were associated with an increased risk for BO included the following: peripheral blood-derived stem cell, a busulfan-based conditioning regimen, interval from diagnosis to transplant > or = 14 months, female donor to male recipient sex match, prior interstitial pneumonitis, and an episode of moderate-to-severe acute graft-vs-host disease (GVHD).	16002929
Pneumonia, Interstitial	Stem Cell Exhaustion	In addition to corroborating previously reported risk factors, such as acute GVHD and a busulfan-based conditioning regimen, we found that peripheral blood stem-cell transplantation, long duration to transplant, female donor to male recipient, and a prior episode of interstitial pneumonitis are associated with an increased risk for BO.	16002929
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Recent studies concerning the pathophysiology of myelodysplastic syndromes (MDS) have shown evidences for the existence of complex interactions between hematopoietic stem cells and the bone marrow (BM) microenvironment.	16005514
Varicella Zoster Encephalitis	Stem Cell Exhaustion	Fatal varicella zoster virus encephalitis in two patients following allogeneic hematopoietic stem cell transplantation.	16008607
Virus Diseases	Stem Cell Exhaustion	Reduced cellular immunocompetence following allogeneic hematopoietic stem cell transplantation (aHSCT) increases susceptibility to viral infections.	16008607
Multiple Myeloma	Stem Cell Exhaustion	In patients with multiple myeloma, irradiation of bone marrow prior to mobilization of autologous peripheral blood progenitor cells (PBPCs) may lead to a reduced yield of CD34+ cells.	16012838
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Colony formation of AML progenitors was inhibited in a dose-dependent fashion, whereas normal CD34+ progenitor cells were less affected.	16014563
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	MDM2 inhibition synergistically enhanced cytotoxicity of cytosine arabinoside and doxorubicin in AML blasts but not in normal hematopoietic progenitor cells.	16014563
Sample Size Calculation	Stem Cell Exhaustion	To determine the genes specifically expressed in the immune system in SSc by analysis of the gene expression profile of peripheral blood mononuclear cells (PBMC) from patients with SSc, including those treated with haematopoietic stem cell transplantation (HSCT).	16014681
Prostate carcinoma, prostate stem cell antigen	Stem Cell Exhaustion	Complete androgen ablation suppresses prostate stem cell antigen (PSCA) mRNA expression in human prostate carcinoma.	16015594
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Prognostic value of the age-adjusted International Prognostic Index in chemosensitive recurrent or refractory non-Hodgkin's lymphomas treated with high-dose BEAM therapy and autologous stem cell transplantation.	16019530
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Autologous or allogeneic stem cell transplantation as post-remission therapy in refractory or relapsed acute myeloid leukemia after highly intensive chemotherapy.	16019551
Refractory Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma	Stem Cell Exhaustion	Cure of a patient with profoundly chemotherapy-refractory primary mediastinal large B-cell lymphoma: role of rituximab, high-dose therapy, and allogeneic stem cell transplantation.	16019561
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Granulocytic sarcoma of the heart: extramedullary relapse of acute myeloblastic leukemia after allogeneic stem cell transplantation successfully treated by chemotherapy alone.	16019562
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 28-year-old man with relapsed acute myelogenous leukemia (AML-M2) had undergone a non-myeloablative allogeneic peripheral stem cell transplantation.	16019562
Autoimmune state	Stem Cell Exhaustion	In this case, peripheral stem-cell transfusion with its associated chemotherapy failed to benefit the patient's vision; indications of autoimmunity appeared to increase following this treatment.	16019685
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Conditioning with 8-Gy total body irradiation and fludarabine for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia.	16020510
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Seventy-one patients with acute myeloid leukemia (AML), most of them (63/71) considered ineligible for conventional allogeneic hematopoietic stem cell transplantation (HSCT), were enrolled into a phase 2 study on reduced-intensity myeloablative conditioning with fractionated 8-Gy total body irradiation (TBI) and fludarabine (120 mg/m2).	16020510
Osseous metaplasia, Neoplasms	Stem Cell Exhaustion	The pathogenesis of osseous metaplasia in epithelial tumors of the ovary is unclear; however, it is probable that a metaplastic process involving multipotential stromal stem cells results in bone formation.	16023183
Thrombomodulin Alfa, Thrombotic Microangiopathies	Stem Cell Exhaustion	Thrombotic microangiopathy (TMA) is a significant complication after hematopoietic stem-cell transplantation (HSCT); however, there is little information on it following reduced-intensity cord blood transplantation (RI-CBT).	16025150
Paroxysmal nocturnal hemoglobinuria, Anemia, Hemolytic	Stem Cell Exhaustion	PNH is a hemolytic anemia due to an acquired red blood cell membrane defect at the stem cell level.	16026067
Lysosomal Storage Diseases, Pfaundler-Hurler Syndrome	Stem Cell Exhaustion	Hurler syndrome is a lysosomal storage disease resulting in fatal cardiac or neurologic sequelae unless alpha-iduronidase production is reconstituted with hematopoietic stem cell transplantation.	16027706
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Control of advanced and refractory acute myelogenous leukaemia with sirolimus-based non-myeloablative allogeneic stem cell transplantation.	16029454
Febrile Neutropenia	Stem Cell Exhaustion	We report on 232 patients undergoing autologous haematopoietic stem cell transplantation (ASCT) entered into a multicentre, randomised trial comparing the efficacy and tolerability of meropenem (MPM) with that of piperacillin/tazobactam (P/T) as empirical antimicrobial first-line therapy for febrile neutropenia.	16029455
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	[Nonmyleoablative allogeneic stem cell transplantation combined with imatinib in treatment of chronic myeloid leukemia: a clinical study].	16029566
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	To study the effect of nonmyeloablative allogeneic peripheral blood stem cell (NST) transplantation combined with imatinib in the treatment of chronic myeloid leukemia (CML).	16029566
leukemia	Stem Cell Exhaustion	We report here that although no such mutations were detected in 44 adult leukemia patients screened, Shp2 expression levels were significantly elevated in primary leukemia cells and leukemia cell lines, as compared with normal hematopoietic progenitor cells.	16030196
Mantle cell lymphoma	Stem Cell Exhaustion	Primary allogeneic T-cell responses against mantle cell lymphoma antigen-presenting cells for adoptive immunotherapy after stem cell transplantation.	16033850
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	In patients treated with allogeneic stem cell transplantation for advanced mantle cell lymphoma (MCL), complete sustained remissions have been observed illustrating susceptibility of MCL cells to a graft-versus-lymphoma effect.	16033850
Medial collateral ligament	Stem Cell Exhaustion	These results show the feasibility to generate primary allogeneic T-cell responses against MCL-APC, and may provide new immunotherapeutic tools to further exploit the graft-versus-lymphoma effect following allogeneic stem cell transplantation in patients with MCL.	16033850
Amyloidosis	Stem Cell Exhaustion	Excessive fluid accumulation during stem cell mobilization: a novel prognostic factor of first-year survival after stem cell transplantation in AL amyloidosis patients.	16037390
Amyloidosis	Stem Cell Exhaustion	High-dose melphalan followed by stem cell transplantation (HDM-SCT) has become the treatment of choice for patients with immunoglobulin light chain amyloidosis (AL).	16037390
Graft-vs-Host Disease	Stem Cell Exhaustion	Both horse and rabbit ATG include multiple antibodies against T-cell surface antigens and have been used extensively in allogeneic hematopoietic progenitor cell transplantation (HPCT) for the treatment and prevention of graft-versus-host disease or graft rejection.	16041311
Peripheral Stem Cell Transplantation, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Improved outcome for peripheral blood stem cell transplantation for advanced primary myelodysplastic syndrome.	16041312
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Stem cell transplantation for myelodysplastic syndrome (MDS) is characterized by high transplant-related mortality (TRM), especially in older patients and those with more advanced disease.	16041312
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	A new schedule of CHOP/rituximab plus granulocyte-macrophage colony-stimulating factor is an effective rescue for patients with aggressive lymphoma failing autologous stem cell transplantation.	16041313
Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	From 1999 to 2002, 20 patients with aggressive non-Hodgkin lymphoma, among 28 who failed autologous peripheral blood progenitor cell transplantation, were rescued with cyclophosphamide, hydroxydaunomycin, Oncovin (vincristine), and prednisone (CHOP)/rituximab (RTX) and granulocyte-macrophage colony-stimulating factor (GM-CSF).	16041313
palladium	Stem Cell Exhaustion	Of these 16 patients, 10 (63%) continued to respond to 2 degrees ST. Of the 15 patients who had stable disease following 1 degrees ST, 5 (33%) responded to 2 degrees ST. Only one of the 24 (4%) with progressive disease (PD) following 1 degrees ST, responded to 2 degrees ST. 25 of the 57 patients ultimately underwent stem cell transplantation.	16042685
Chronic myeloproliferative disorder	Stem Cell Exhaustion	PV and ET are chronic myeloproliferative diseases whose heterogeneity of stem cell origin and clonal development has been established through analysis of X-chromosome inactivation patterns.	16042688
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A cost comparison between myeloablative and nonmyeloablative allogeneic stem cell transplant in patients with acute myeloid leukemia.	16044135
Amyloidosis	Stem Cell Exhaustion	Serum free light-chain responses after high-dose intravenous melphalan and autologous stem cell transplantation for AL (primary) amyloidosis.	16044137
Amyloidosis	Stem Cell Exhaustion	Serum free light-chain (FLC) concentrations were measured by a sensitive nephelometric immunoassay in 66 patients with AL amyloidosis before and after treatment with high-dose melphalan and autologous stem cell transplantation (HDM/SCT).	16044137
Lymphoma	Stem Cell Exhaustion	In an effort to improve the outcome of poor-risk lymphoma patients, we evaluated a novel regimen of tandem high-dose chemotherapy (THDC) with autologous stem cell transplantation.	16044139
Hypertrophy, Endochondral Ossification	Stem Cell Exhaustion	Recent evidence indicates that a major drawback of current cartilage- and disc-tissue engineering is that human mesenchymal stem cells (MSCs) rapidly express type X collagen-a marker of chondrocyte hypertrophy associated with endochondral ossification.	16044417
Radiation myelitis	Stem Cell Exhaustion	Meningeal hematopoiesis following radiation myelitis in a hematopoietic stem-cell transplant recipient.	16044440
Paroxysmal nocturnal hemoglobinuria, Hematological Disease	Stem Cell Exhaustion	PNH is a rare clonal disorder of hematopoietic stem cells, therefore all blood cells lineages are involved.	16044949
Infection of bloodstream	Stem Cell Exhaustion	Patients at the University Hospital Birmingham NHS Foundation Trust, U.K. who underwent stem cell transplantation and were diagnosed with CVC-related bloodstream infection due to CoNS whilst on the bone marrow transplant unit were studied.	16045993
Toxic effect	Stem Cell Exhaustion	The strategy for treating these patients is through reinduction chemotherapy followed by allogeneic stem cell transplantation, provided that the toxicity of the salvage regimen is acceptable.	16047203
Sarcomatoid Renal Cell Carcinoma	Stem Cell Exhaustion	X-chromosome inactivation analysis data suggest that both clear cell and sarcomatoid components of renal cell carcinomas are derived from the same progenitor cell.	16047350
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, S100A4 protein, human, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Clinical course and cytogenetic analysis suggest that myelodysplasia (MDS) is one step in a multistep model of malignant transformation of haematopoietic stem cells to acute myeloid leukaemia (AML).	16048496
Congestive heart failure	Stem Cell Exhaustion	Twenty-eight patients with CHF treated with Epo for a mean period of 28 months were compared to a matched group (n = 28) with regard to the number of circulating hematopoietic and endothelial stem cells (either CD34+, CD34+/CD45+, CD34+/CD133+, CD34+/VEGF-R2+ or CD34+/CD133+/VEGF-R2+) as well as their proliferative and adhesive capacity.	16048724
Congestive heart failure	Stem Cell Exhaustion	No differences were observed in circulating numbers of hematopoietic and endothelial stem cells between CHF patients chronically treated with Epo or untreated.	16048724
Multiple Myeloma	Stem Cell Exhaustion	The current study examined general religiousness and two modes of cancer-specific religious coping, drawing closer to faith (positive) and struggling with faith (negative), among 213 multiple myeloma patients evaluated at the same point in treatment, during their initial work-up for autologous stem cell transplantation.	16049629
Myocardial Ischemia	Stem Cell Exhaustion	Aim of our study was to establish the impact of different well-known mobilizing cytokines on spontaneous stem cell mobilization in patients with different ischemic heart syndromes, such as the AMI and the chronic stable angina (CSA), compared to healthy controls.	16051386
Acute myocardial infarction	Stem Cell Exhaustion	Several reports showed an increase of CD34(+) stem/progenitor cell count early after an acute myocardial infarction (AMI), suggesting a contribution of bone marrow cells in myocardial regeneration after the acute event.	16051386
Rheumatoid Arthritis	Stem Cell Exhaustion	Long-term followup of health status in patients with severe rheumatoid arthritis after high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation.	16052541
Rheumatoid Arthritis	Stem Cell Exhaustion	High-dose chemotherapy (HDC) followed by autologous hematopoietic stem cell transplantation (HSCT) is a new treatment for patients with severe, refractory rheumatoid arthritis (RA).	16052541
Specialty Type - cancer	Stem Cell Exhaustion	Performance limitations and participation restrictions among childhood cancer survivors treated with hematopoietic stem cell transplantation: the bone marrow transplant survivor study.	16061776
BARRIER	Stem Cell Exhaustion	Inflammatory response to mucosal barrier injury after myeloablative therapy in allogeneic stem cell transplant recipients.	16062174
Gastrointestinal mucositis	Stem Cell Exhaustion	We noted a significant increase of interleukin-8 (IL-8), LBP and CRP mirroring the pattern of mucosal barrier injury as measured by gut integrity (lactulose/rhamnose ratio), daily mucositis score (DMS) and serum citrulline concentrations of 32 haematopoietic stem cell transplant (HSCT) recipients following intensive myeloablative therapy.	16062174
Liver Dysfunction	Stem Cell Exhaustion	Protein C and procollagen III peptide levels in patients with hepatic dysfunction after allogeneic hematopoietic stem cell transplantation.	16062176
Venoocclusive disease	Stem Cell Exhaustion	Veno-occlusive disease (VOD) is one of the most serious complications following hematopoietic stem cell transplantation (HSCT) and is associated with a high mortality.	16062176
Amyloidosis	Stem Cell Exhaustion	Recent reports from large amyloidosis referral centers suggest that primary systemic AL amyloidosis patients treated with high-dose melphalan (HDM) and autologous stem cell transplantation (ASCT) survive longer than historical controls treated with less intensive chemotherapy, despite high transplant-related mortality (TRM) rates of >10%.	16062177
PAFAH1B1 wt Allele	Stem Cell Exhaustion	To gain insight into this condition, we analyzed gene expression profiles of marrow CD34+ progenitor cells from normal-karyotype, low-blast-count MDS patients, age-matched controls, and patients with non-MDS anemia.	16076868
PAFAH1B1 wt Allele	Stem Cell Exhaustion	They also provide the rationale for a larger study to evaluate the diagnostic utility of reduced B-cell progenitor number as a diagnostic biomarker of early low-risk MDS, which can pose a diagnostic challenge.	16076868
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Evidence for reduced B-cell progenitors in early (low-risk) myelodysplastic syndrome.	16076868
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Flow cytometry on unfractionated marrow from independent samples also demonstrated reduced B-cell progenitors in MDS patients compared with healthy controls.	16076868
Hypertrophic Cardiomyopathy, leukemia	Stem Cell Exhaustion	Relapse of T-cell all after stem cell transplant presenting as hypertrophic cardiomyopathy: the value of non-invasive diagnostic imaging in detecting cardiac leukemia.	16078227
Acute lymphocytic leukemia, CLTC gene, BCR gene, Hypertrophic Cardiomyopathy	Stem Cell Exhaustion	We describe a 14-year-old female with acute lymphoblastic leukemia (ALL) with a mediastinal mass at diagnosis who developed hypertrophic cardiomyopathy (HC) after stem cell transplantation (SCT).	16078227
Arthritis, Infectious	Stem Cell Exhaustion	Transplant of mesenchymal stem cells and hydroxyapatite ceramics to treat severe osteochondral damage after septic arthritis of the knee.	16078345
Arthritis, Infectious	Stem Cell Exhaustion	We describe a 21-year-old man with a large osteochondral defect of the knee after septic arthritis, successfully treated by transplant of mesenchymal stem cells (MSC) from bone marrow and a new type of interconnected porous hydroxyapatite ceramic (IP-CHA).	16078345
Hemolysis (biological function)	Stem Cell Exhaustion	Severe immunohematologic complications after ABO-mismatched allogeneic blood peripheral blood progenitor cell (PBPC) transplantation (PBPCT), including pure red cell aplasia and immune hemolysis, have been described.	16078929
Graft-vs-Host Disease	Stem Cell Exhaustion	Since engraftment of allogeneic stem cells depends not only on adequate immunosuppression but also on successful hematopoietic competition, and considering the fact that residual lymphocytes of host origin may play a beneficial role in preventing graft-versus-host disease (GVHD), we used low doses of oral busulfan as a single agent for conditioning prior to stem cell transplantation (SCT) in recipients of transplants from a variety of donors.	16079108
Hypoxia	Stem Cell Exhaustion	Also, activation of STAT proteins by hypoxia may play an important role in the physiological phenomenon of embryonic stem cells and old cells with hypoxic conditions.	16084091
Peripheral Blood Stem Cells	Stem Cell Exhaustion	High dose chemotherapy with peripheral blood stem cell support for MPE in six patients conferred no clear survival advantage.	16085553
Mycoses	Stem Cell Exhaustion	Haemopoietic progenitor cell transplantation in patients with previous history of invasive fungal infection.	16085554
Mycoses	Stem Cell Exhaustion	Marques de Valdecilla (Spain) and the Royal Marsden NHS Trust (UK) was to analyse the outcome of patients who underwent haemopoietic progenitor cell transplantation (HPCT) after a previous history of Invasive fungal infections (IFI).	16085554
Muscular Dystrophy, Duchenne, Cord Blood Stem Cell Transplantation	Stem Cell Exhaustion	[Therapy of Duchenne muscular dystrophy with umbilical cord blood stem cell transplantation].	16086277
Muscular Dystrophy, Duchenne	Stem Cell Exhaustion	To analyze a Duchenne muscular dystrophy(DMD) patient's muscular regeneration, dystrophin expression and locomotive variation before and after he underwent umbilical cord blood stem cell transplantation in order to assess the therapeutic effect.	16086277
Muscular Dystrophy, Duchenne, Allogeneic Hematopoietic Stem Cell Transplantation	Stem Cell Exhaustion	The therapy of Duchenne muscular dystrophy with allogeneic umbilical cord blood hematopoietic stem cell transplantation may reset up the blood-making function, decrease the serum CK level, restore the dystrophin in muscles, and improve the locomotive function of the DMD boy.	16086277
Depression, CTCAE, Specialty Type - cancer	Stem Cell Exhaustion	Role of depression as a predictor of mortality among cancer patients after stem-cell transplantation.	16087949
Depression, CTCAE, Specialty Type - cancer	Stem Cell Exhaustion	To determine the association between depression and survival among cancer patients at 1, 3, and 5 years after stem-cell transplantation (SCT).	16087949
Electrocardiogram: myocardial infarction (finding), Nonstress test	Stem Cell Exhaustion	Circulating endothelial progenitor cells and coronary collaterals in patients with non-ST segment elevation myocardial infarction.	16088214
Ischemia	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) are bone marrow-derived cells that are augmented in response to ischemia and incorporated into neovascularization sites.	16088214
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation in myeloma: the St James's Hospital experience, 1997-2003.	16094909
Multiple Myeloma	Stem Cell Exhaustion	High-dose treatment with autologous stem cell transplantation (ASCT) has become the standard of care for patients with myeloma below the age of 65 years.	16094909
EIF2AK3 wt Allele	Stem Cell Exhaustion	Bone marrow-derived stem cells of a 16-year-old WRS patient were cultivated and stimulated by dexamethasone, ascorbic acid and beta-glycerolphosphate (DAG) over 21 days.	16097434
Chondroblasts, EIF2AK3 wt Allele	Stem Cell Exhaustion	To elucidate the osteoblastic and chondroblastic regeneration potential in WRS, a progenitor cell culture system was used.	16097434
EIF2AK3 wt Allele	Stem Cell Exhaustion	To date, there are no data about the differentiation capacity of WRS progenitor cells available in the literature.	16097434
Neoplasms, Primary Neoplasm	Stem Cell Exhaustion	We describe the case of a 17-year-old boy with a right apical paraspinal Ewing's tumour in the neck treated with induction chemotherapy, high-dose chemotherapy (busulfan and melphalan) with peripheral stem-cell rescue and, 4 months later, radiotherapy to the primary tumour site (cervical cord received 50 Gy in 30 fractions).	16097572
Disease, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, peripheral blood, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell disorders that are characterized by morphology identifying dysplastic changes in one or more cell lineages, peripheral blood cytopenias and a propensity to evolve into secondary acute myeloid leukemia (AML).	16098587
Mantle cell lymphoma	Stem Cell Exhaustion	Chemotherapy with rituximab followed by high-dose therapy and autologous stem cell transplantation in patients with mantle cell lymphoma.	16104036
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	The authors evaluated the efficacy of chemotherapy combined with rituximab followed by high-dose therapy (HDT) plus autologous stem cell transplantation in patients with mantle cell lymphoma (MCL).	16104036
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Outcome of progressive disease after autologous stem cell transplantation in patients with non-Hodgkin's lymphoma: a nation-wide survey.	16104875
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	To analyse outcome and prognostic factors in non-Hodgkin's lymphoma (NHL) patients who progress after autologous stem cell transplantation (ASCT).	16104875
Hematological Disease	Stem Cell Exhaustion	Sixteen patients (50%) had a relapsed or resistant hematologic disease, while 12 patients were in complete remission and 4 were at onset of disease; 8/32 (25%) developed IFI after a hematopoietic stem cell transplant (HSCT) procedure.	16104879
Parkinsonian Disorders, Pick Disease of the Brain	Stem Cell Exhaustion	Musashi-1 (Msi-1), an RNA-binding protein associated with neural progenitor cells, has been shown by others to increase the accumulation of tau isoforms in intracellular inclusions in frontotemporal dementia and parkinsonism linked to chromosome 17.	16106215
Vasculitis, CTCAE, Impaired T cell function	Stem Cell Exhaustion	Circulating inflammatory endothelial cells contribute to endothelial progenitor cell dysfunction in patients with vasculitis and kidney involvement.	16107582
Blood Vessel, Granulomatosis with polyangiitis	Stem Cell Exhaustion	With the use of Wegener's granulomatosis as a study model, whether circulating inflammatory endothelial cells (IEC) can (1) be used as a disease activity marker and (2) contribute to sustained vascular damage by inducing endothelial progenitor cell (EPC) dysfunction were examined.	16107582
Huntingtons Disease Pathway	Stem Cell Exhaustion	The results demonstrated the presence of increased numbers of neuropeptide Y positive cells in the Huntington's disease subependymal layer compared with the normal subependymal layer, suggesting that neuropeptide Y neurons may play a role in progenitor cell proliferation.	16108100
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	The effect of absolute lymphocyte count recovery kinetics on survival after autologous stem cell transplantation for non-Hodgkin's lymphoma.	16109605
Hematologic Neoplasms	Stem Cell Exhaustion	Absolute lymphocyte count (ALC) >or=500 cells/microl at day 15 after autologous stem cell transplantation (ASCT) is a powerful independent, prognostic indicator for survival in multiple hematological malignancies.	16109605
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Sequential regimen of chemotherapy, reduced-intensity conditioning for allogeneic stem-cell transplantation, and prophylactic donor lymphocyte transfusion in high-risk acute myeloid leukemia and myelodysplastic syndrome.	16110027
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	To improve the effect of allogeneic stem-cell transplantation by sequential use of intensive chemotherapy, reduced-intensity conditioning (RIC), and prophylactic donor lymphocyte transfusions (pDLTs) in high-risk acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).	16110027
Primary Myelofibrosis	Stem Cell Exhaustion	Circulating CD34+, CD133+, and vascular endothelial growth factor receptor 2-positive endothelial progenitor cells in myelofibrosis with myeloid metaplasia.	16110028
MYELODYSPLASTIC SYNDROME, Cytopenia	Stem Cell Exhaustion	Myelodysplastic syndromes are clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis and peripheral cytopenias.	16111531
Multiple Myeloma	Stem Cell Exhaustion	Bortezomib (Velcade) for progressive myeloma after autologous stem cell transplantation and thalidomide.	16111749
Multiple Myeloma	Stem Cell Exhaustion	Twenty-one patients with multiple myeloma, all relapsed after frontline autologous stem cell transplantation and all relapsed again after or resistant to thalidomide (employed as second line treatment) received bortezomib (1.3 mg/m(2) body surface twice weekly for 2 weeks followed by an interval of 10-12 days) without adjunct of steroids as third line therapy.	16111749
Myeloid Leukemia	Stem Cell Exhaustion	Human stem cell factor-antibody [anti-SCF] enhances chemotherapy cytotoxicity in human CD34+ resistant myeloid leukaemia cells.	16112192
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The AML blast cells in these elderly patients are often characterised by several unfavourable covariates that predict the poor treatment outcome, including high stem cell marker CD34 expression, minimally or undifferentiated features, high P-glycoprotein expression, high bcl-2/bax ratio, unfavourable karyotype and more frequent internal tandem duplications (ITDs) and mutations of class III receptor-type tyrosine kinase for key haematopoietic cytokines: Flt-3 (receptor for Flt-ligand), c-kit (receptor for stem cell factor) and fms (receptor for M-CSF).	16112192
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Therefore, the present study was performed to evaluate whether stem cell factor-antibody (anti-SCF) can enhance the efficacy of the two main chemotherapeutic drugs used in AML therapy: cytarabine and daunorubicin at low doses in human-resistant CD34+ AML cells, in an attempt to identify a novel effective regimen with tolerable side-effects for elderly AML patients.	16112192
Chronic graft-versus-host disease, Acute lymphocytic leukemia	Stem Cell Exhaustion	Myeloablative allogeneic hematopoietic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia in adults: significant roles of total body irradiation and chronic graft-versus-host disease.	16113659
Philadelphia chromosome positive chronic myelogenous leukemia, BCR gene	Stem Cell Exhaustion	Disease-free survival in Philadelphia chromosome-positive ALL (Ph + ALL) is very poor, and allogeneic hematopoietic stem cell transplantation (allo-HSCT) is currently considered the only procedure with curative potential.	16113659
Multiple Myeloma	Stem Cell Exhaustion	Genetic risk identifies multiple myeloma patients who do not benefit from autologous stem cell transplantation.	16113669
Hematologic Neoplasms	Stem Cell Exhaustion	Comparison between reduced intensity and conventional myeloablative allogeneic stem-cell transplantation in patients with hematologic malignancies aged between 50 and 59 years.	16113674
Hematologic Neoplasms	Stem Cell Exhaustion	To evaluate the efficacy of reduced-intensity stem-cell transplantation (RIST), we retrospectively compared outcomes of 207 consecutive Japanese patients aged between 50 and 59 years with hematologic malignancies who received RIST (n=70) and conventional stem-cell transplantation (CST) (n=137).	16113674
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Patients received cyclophosphamide, hydroxydaunomycin, Oncovin, prednisone (CHOP)-like therapy, the non-Hodgkin lymphoma (NHL)-15 regimen or upfront autologous stem cell transplantation (ASCT) on Institutional Review Board approved trials or according to the institutional guidelines.	16115124
Aortic Valve Stenosis	Stem Cell Exhaustion	We assessed aortic valves from patients with non-rheumatic aortic valve stenosis (AS) and with degenerative aortic valve bioprostheses (BP) for the presence of progenitor cell and leukocyte subtype-specific markers.	16115807
Peripheral Blood Stem Cells	Stem Cell Exhaustion	The maximum tolerated dose of radioimmunotherapy and fixed-dose paclitaxel with peripheral blood stem cell support has not been reached.	16115934
Fever, Childhood Breast Carcinoma, Hemorrhage	Stem Cell Exhaustion	Three breast cancer patients required infusion of previously harvested peripheral blood stem cells because of neutropenic fever or bleeding.	16115934
Renal Insufficiency	Stem Cell Exhaustion	Efforts to improve severely impaired myocardial function include transplantation of autologous hematopoietic side population (SP) stem cells.	16116030
Hyperbilirubinemia, Venoocclusive disease	Stem Cell Exhaustion	Grade 3 or 4 hyperbilirubinemia and hepatic aspartate aminotransferase and alanine aminotransferase elevations were reported in 29%, 18%, and 9% of patients, respectively; 0.9% of patients who did not undergo prior or subsequent hematopoietic stem cell transplantation developed hepatic venoocclusive disease after GO treatment.	16116598
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Post-transplant lymphoproliferative disorder (PTLD) is a complication of solid organ and allogeneic hematopoietic stem cell transplantation (HSCT); following autologous HSCT only rare cases of PTLD have been reported.	16117828
Acute myocardial infarction	Stem Cell Exhaustion	Assessment of left ventricular segmental function after autologous bone marrow stem cells transplantation in patients with acute myocardial infarction by tissue tracking and strain imaging.	16117862
Acute myocardial infarction	Stem Cell Exhaustion	Emerging evidence suggests that stem cells can be used to improve cardiac function in patients after acute myocardial infarction.	16117862
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Donor cell leukemia is a rare complication after allogeneic hematopoietic stem cell transplantation.	16118319
Precursor cell lymphoblastic lymphoma	Stem Cell Exhaustion	It is believed that the rare NK blastic lymphoma develops from NK progenitor cells.	16118958
leukemia, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	To establish a mouse model bearing transplantable human chronic myeloid leukemia for hematopoietic stem cell transplantation to treat leukemia, 4 - 5-week-old female BALB/c nude mice were given cyclophosphamide 2 mg/mouse at day -2, -1, and then the human chronic myeloid leukemia K562 cells were engrafted into the mice at day 0 by injection via tail vein or peritoneal cavity.	16129041
Cardiovascular Diseases	Stem Cell Exhaustion	History of cardiovascular disease is associated with endothelial progenitor cells in peritoneal dialysis patients.	16129215
Kidney Failure, Chronic, Cardiovascular Diseases	Stem Cell Exhaustion	It is unknown whether traditional cardiovascular disease risk factors influence the number of endothelial progenitor cells (EPCs) and whether numbers of EPCs correlate with endothelial function in patients with end-stage renal disease.	16129215
Neutropenia	Stem Cell Exhaustion	The influence of patient's age, underlying disease, hematopoietic stem cell transplantation, neutropenia, graft versus host disease, and antifungal therapy onset was also statistically considered.	16129254
Central neuroblastoma	Stem Cell Exhaustion	Myeloablative megatherapy with autologous stem-cell rescue versus oral maintenance chemotherapy as consolidation treatment in patients with high-risk neuroblastoma: a randomised controlled trial.	16129365
Terminal illness, Central neuroblastoma	Stem Cell Exhaustion	295 patients with high-risk neuroblastoma (ie, patients with stage 4 disease aged older than 1 year or those with MYCN-amplified tumours and stage 1, 2, 3, or 4S disease or stage 4 disease and <1 year old) were randomly assigned to myeloablative megatherapy (melphalan, etoposide, and carboplatin) with autologous stem-cell transplantation (n=149) or to oral maintenance chemotherapy with cyclophosphamide (n=146).	16129365
Cessation of life, Central neuroblastoma	Stem Cell Exhaustion	Myeloablative chemotherapy with autologous stem-cell transplantation improves the outcome for children with high-risk neuroblastoma despite the raised risk of treatment-associated death.	16129365
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Factors associated with early molecular remission after T cell-depleted allogeneic stem cell transplantation for chronic myelogenous leukemia.	16131570
Graft-vs-Host Disease, Acute GVH disease, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Eighty patients with chronic myeloid leukemia (CML) underwent T cell-depleted stem cell transplantation from an HLA-identical sibling, with add-back of donor T cells on days 30 to 45 and days 60 to 100 in patients in whom grade 2 or greater acute graft-versus-host disease (GVHD) developed.	16131570
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia.	16131571
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	We report here on the long-term follow-up on 162 patients with high-risk chronic lymphocytic leukemia (CLL) who have undergone hematopoietic stem cell transplantation (SCT) at a single center from 1989 to 1999.	16131571
Lymphoma, Non-Hodgkin, Multiple Myeloma	Stem Cell Exhaustion	Prospective randomized comparative observation of single- vs split-dose lenograstim to mobilize peripheral blood progenitor cells following chemotherapy in patients with multiple myeloma or non-Hodgkin's lymphoma.	16132903
Hematologic Neoplasms	Stem Cell Exhaustion	In patients with hematologic malignancies, granulocyte colony-stimulating factor (G-CSF) following chemotherapy is widely used to mobilize peripheral blood progenitor cells (PBPCs), but there have been no trials comparing schedules of G-CSF following chemotherapy.	16132903
Corneal Neovascularization	Stem Cell Exhaustion	In 4 cases a limbal stem cell deficiency occurred with the consequence of corneal vascularisation.	16133022
Disease, PAFAH1B1 wt Allele, Cytopenia, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is a heterogenous group of stem cell disorders usually characterized by progressive refractory cytopenias, which could progress to acute myeloid leukemia.	16134776
Graft-vs-Host Disease, Pulmonary arterial hypertension	Stem Cell Exhaustion	Late-onset pulmonary arterial hypertension in association with graft-versus-host disease after allogeneic stem-cell transplantation.	16138351
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We report our experience with a 21-year-old female with accelerated-phase chronic myeloid leukemia who underwent allogeneic hematopoietic stem cell transplantation from a matched, unrelated donor.	16138357
Hodgkin Disease, Multiple Myeloma, Lymphoma, Non-Hodgkin, LIPC gene, Lymphoma, Non-Hodgkin, Familial, Morular Metaplasia of the Endometrium	Stem Cell Exhaustion	Patients who proceeded to haematopoietic stem cell transplants (HDTs) received conditioning therapy with BEAM [for the Hodgkin's Lymphoma (HL) and non-Hodgkin's Lymphoma (NHL) groups], or melphalan 100 mg/m2 and mitoxantrone [for the multiple myeloma (MM) patients].	16142354
Malignant Neoplasms	Stem Cell Exhaustion	In conclusion, our study confirms that IEV +/- HDT is a well-tolerated and effective salvage treatment for lymphoid malignancies, and that IEV acts as an excellent stem cell mobiliser.	16142354
Malignant Neoplasms	Stem Cell Exhaustion	Ifosfamide, epirubicin, etoposide (IEV) and autologous peripheral blood progenitor cell transplant: a feasible and effective salvage treatment for lymphoid malignancies.	16142354
Hematologic Neoplasms	Stem Cell Exhaustion	Thirty-four patients (72%) had an underlying haematological malignancy, and 18 patients (38%) developed GI-CMVd following hematopoietic stem cell transplantation (HSCT).	16143517
Multiple Myeloma	Stem Cell Exhaustion	Tandem autologous stem cell transplantation in high-risk de novo multiple myeloma: final results of the prospective and randomized IFM 99-04 protocol.	16144800
Cytomegalovirus Infections	Stem Cell Exhaustion	Neurological manifestation of CMV disease after allogeneic haematopoietic stem cells transplantation--a case report.	16146077
Primary central nervous system lymphoma	Stem Cell Exhaustion	First-line autologous stem cell transplantation in primary CNS lymphoma.	16146534
Primary central nervous system lymphoma	Stem Cell Exhaustion	In this article, we report six cases of PCNSL treated by first-line induction chemotherapy followed by intensive chemotherapy and autologous stem cell transplantation (ASCT).	16146534
Virus Diseases	Stem Cell Exhaustion	Donor leukocyte infusion (DLI) has been successfully used for some life-threatening viral infections after stem cell transplantation (SCT).	16146543
Cessation of life, Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Endothelial progenitor-cell levels were not predictive of myocardial infarction or of death from all causes.	16148285
Coronary Arteriosclerosis	Stem Cell Exhaustion	The number of endothelial progenitor cells positive for CD34 and kinase insert domain receptor (KDR) was determined with the use of flow cytometry in 519 patients with coronary artery disease as confirmed on angiography.	16148285
Cessation of life, Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	After 12 months, we evaluated the association between baseline levels of endothelial progenitor cells and death from cardiovascular causes, the occurrence of a first major cardiovascular event (myocardial infarction, hospitalization, revascularization, or death from cardiovascular causes), revascularization, hospitalization, and death from all causes.	16148285
Cessation of life	Stem Cell Exhaustion	The cumulative event-free survival rate increased stepwise across three increasing baseline levels of endothelial progenitor cells in an analysis of death from cardiovascular causes, a first major cardiovascular event, revascularization, and hospitalization.	16148285
Cessation of life	Stem Cell Exhaustion	After adjustment for age, sex, vascular risk factors, and other relevant variables, increased levels of endothelial progenitor cells were associated with a reduced risk of death from cardiovascular causes (hazard ratio, 0.31; 95 percent confidence interval, 0.16 to 0.63; P=0.001), a first major cardiovascular event (hazard ratio, 0.74; 95 percent confidence interval, 0.62 to 0.89; P=0.002), revascularization (hazard ratio, 0.77; 95 percent confidence interval, 0.62 to 0.95; P=0.02), and hospitalization (hazard ratio, 0.76; 95 percent confidence interval, 0.63 to 0.94; P=0.01).	16148285
Cessation of life	Stem Cell Exhaustion	The level of circulating CD34+KDR+ endothelial progenitor cells predicts the occurrence of cardiovascular events and death from cardiovascular causes and may help to identify patients at increased cardiovascular risk.	16148285
Hypertensive (finding), Hypertension, CTCAE	Stem Cell Exhaustion	Endothelial progenitor cell senescence is accelerated in both experimental hypertensive rats and patients with essential hypertension.	16148606
Graft-vs-Host Disease, Communicable Diseases	Stem Cell Exhaustion	Twelve (41%) of 29 hematopoietic stem cell transplant (HSCT) recipients had received transplantation within 12 months of the infection diagnosis; 11 patients had graft-versus-host disease (chronic in 10).	16148730
Cytomegalovirus Infections, Guillain-Barre Syndrome	Stem Cell Exhaustion	Guillain-Barre syndrome associated with cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation.	16150099
Guillain-Barre Syndrome, Communicable Diseases	Stem Cell Exhaustion	The association between cytomegalovirus (CMV) infection and the development of Guillain-Barre syndrome (GBS) in the setting of allogeneic hematopoietic stem cell transplantation (alloSCT) has been reported only occasionally.	16150099
Infection	Stem Cell Exhaustion	Cytomegalovirus (CMV) infections and CMV-specific cellular immune reconstitution following reduced intensity conditioning allogeneic stem cell transplantation with Alemtuzumab.	16151431
Communicable Diseases	Stem Cell Exhaustion	We studied the incidence and recurrence of Cytomegalovirus (CMV) infection and reactivation in 38 recipients of Alemtuzumab reduced intensity conditioning-stem cell transplantation, and used CMV-HLA tetramer studies to discover if these events correlated with recovery of circulating CMV-specific CD8+ T cells (cytotoxic T lymphocyte (CTLs)).	16151431
Acute myocardial infarction	Stem Cell Exhaustion	Autologous stem cell transplantation in acute myocardial infarction: The ASTAMI randomized controlled trial.	16152682
DHDDS gene, Aggressive course	Stem Cell Exhaustion	We designed this study to evaluate the usefulness of HDS followed by high-dose therapy (HDT) with autologous stem cell transplantation as front-line treatment in different subsets of aggressive NHL.	16157621
Spinal Cord Injuries, Ulcerative Colitis	Stem Cell Exhaustion	HLA-matched UC blood-derived multipotent stem cells were directly transplanted into the injured spinal cord site of a 37-year-old female patient suffering from spinal cord injury (SPI).	16162459
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Autologous stem cell transplantation following induction therapy with an anthracycline-based regimen including interferon-alpha for low-grade non-Hodgkin's lymphoma.	16163187
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	The role of upfront autologous stem cell transplantation (ASCT) in low-grade non-Hodgkin's lymphoma (LGNHL) continues to be an area of investigation.	16163187
Septicemia, Hafnia, Abdominal Abscess, Aplastic, B-Cell Lymphomas	Stem Cell Exhaustion	Abdominal abscess and Hafnia alvei septicemia occurring during the aplastic phase after autologous stem-cell transplantation in a patient with diffuse large B-cell lymphoma.	16163467
Infection	Stem Cell Exhaustion	Infections due to Hafnia alvei are rare, and this is the first reported case of Hafnia alvei septicemia in an adult hematologic patient undergoing a stem-cell transplantation procedure.	16163467
Hematologic Neoplasms	Stem Cell Exhaustion	In a prospective study, tests for detection of GM were performed twice weekly for patients with hematological malignancies who had undergone hematopoetic stem cell transplantation (HSCT) or had received induction and/or consolidation chemotherapy.	16163633
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	High stem cell frequency in acute myeloid leukemia at diagnosis predicts high minimal residual disease and poor survival.	16166428
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In CD34-positive acute myeloid leukemia (AML), the leukemia-initiating event originates from the CD34(+)CD38(-) stem cell compartment.	16166428
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Therefore, the prognostic impact of stem cell frequency in CD34-positive AML was investigated.	16166428
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In vivo data showed that engraftment of AML blasts in nonobese diabetic/severe combined immunodeficient mice directly correlated with stem cell frequency of the graft.	16166428
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Both in vivo data, as well as the correlation studies, show that AML stem cell frequency at diagnosis offers a new prognostic factor.	16166428
Embryonal Carcinoma	Stem Cell Exhaustion	Human embryonal carcinoma (EC) are the stem cells of TGCTs and are pluripotent.	16168501
Malignant Neoplasms	Stem Cell Exhaustion	Modified total body irradiation as a planned second high-dose therapy with stem cell infusion for patients with bone-based malignancies.	16169680
Acute leukemia	Stem Cell Exhaustion	A salvage therapy consisting of amsacrine plus IDAC with or without etoposide appears to be safe and an effective bridge therapy into a stem cell transplantation programme for patients with refractory or relapsed acute leukemia.	16172175
Congestive heart failure	Stem Cell Exhaustion	Levels of the hematopoiesis inhibitor N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP), which is almost exclusively degraded by ACE, were significantly higher in anemic CHF patients and were clearly correlated to erythroid progenitor cell proliferation (r=-0.64, P=0.001).	16172283
Anemia, Congestive heart failure	Stem Cell Exhaustion	The clear correlation between Ac-SDKP and proliferation of erythroid progenitor cells suggests an inhibitory role of Ac-SDKP on hematopoiesis in CHF patients, which may explain the observed anemia in patients treated with ACE inhibitors.	16172283
Tumor of exocrine pancreas	Stem Cell Exhaustion	While double staining experiments suggest a non-neoplastic pluripotent stem cell, in vitro studies demonstrate a transdifferentiation of exocrine tumor cells to a neuroendocrine phenotype.	16173029
Intestinal metaplasia	Stem Cell Exhaustion	Expression of a candidate marker for progenitor cells, Musashi-1, in the proliferative regions of human antrum and its decreased expression in intestinal metaplasia.	16178889
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	Furthermore, immune attack against hematopoietic stem cells that allows PNH clonal expansion might occur only at the onset of AA.	16179371
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Nonmyeloablative stem cell transplantation for myelodysplastic syndrome or acute myeloid leukemia in patients 60 years or older.	16182177
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We analyzed the outcomes of 24 consecutive patients aged >or=60 years with poor-prognosis myelodysplastic syndrome or acute myeloid leukemia undergoing transplantation with nonmyeloablative conditioning using fludarabine (125 mg/m2) and low-dose total body irradiation (2 Gy) followed by allogeneic peripheral blood stem cell grafts from HLA-identical sibling donors.	16182177
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	These data suggest that nonmyeloablative stem cell transplantation is a feasible treatment option in patients aged >or=60 years with poor-prognosis myelodysplastic syndrome or acute myeloid leukemia.	16182177
Hematologic Neoplasms, Respiratory Tract Infections	Stem Cell Exhaustion	Prospective study of the incidence, clinical features, and outcome of symptomatic upper and lower respiratory tract infections by respiratory viruses in adult recipients of hematopoietic stem cell transplants for hematologic malignancies.	16182179
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Direct cardiac injection of G-CSF mobilized bone-marrow stem-cells improves ventricular function in old myocardial infarction.	16183081
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Autologous transplant of bone marrow stem cells (BMSC), although extremely useful after acute myocardial events, has not been evaluated in patients with old (>one-year-old) myocardial infarction.	16183081
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	FLT3 mutations in normal karyotype acute myeloid leukemia in first complete remission treated with autologous peripheral blood stem cell transplantation.	16184177
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We retrospectively analysed the significance of FLT3 mutations in patients with acute myeloid leukemia (AML) having a normal karyotype, who were treated with high-dose chemotherapy and autologous peripheral blood stem cell transplantation (auto-PBSCT).	16184177
Toxic effect, Multiple Myeloma	Stem Cell Exhaustion	Efficacy, toxicity and feasibility of a shorter schedule of DCEP regimen for stem cell mobilization in multiple myeloma.	16184179
Natural Killer Cells	Stem Cell Exhaustion	We report here a case of blastic natural killer (NK)-cell lymphoma treated successfully with autologous peripheral blood stem-cell transplantation (APBSCT).	16184583
Childhood Breast Carcinoma	Stem Cell Exhaustion	A multicenter randomized clinical trial evaluating interleukin-2 activated hematopoietic stem cell transplantation and post-transplant IL-2 for high risk breast cancer patients.	16187232
Childhood Breast Carcinoma	Stem Cell Exhaustion	This Phase III randomized multicenter trial compared progression-free (PFS) and overall survival (OS) for autologous peripheral blood stem cell (aPBSC) transplantation with or without immunotherapy in high-risk breast cancer patients.	16187232
Multiple Myeloma	Stem Cell Exhaustion	Autologous (ASCT) and allogeneic stem cell transplantations (alloBMT) are well-established therapies for multiple myeloma.	16191086
Hypoxic-Ischemic Encephalopathy	Stem Cell Exhaustion	The present study aimed to preliminarily evaluate the effects of human neural stem cell transplantation in treatment of severe neonatal HIE.	16191266
Hypoxic-Ischemic Encephalopathy	Stem Cell Exhaustion	[Treatment of an infant with severe neonatal hypoxic-ischemic encephalopathy sequelae with transplantation of human neural stem cells into cerebral ventricle].	16191266
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Comparative outcome of reduced intensity and myeloablative conditioning regimen in HLA identical sibling allogeneic haematopoietic stem cell transplantation for patients older than 50 years of age with acute myeloblastic leukaemia: a retrospective survey from the Acute Leukemia Working Party (ALWP) of the European group for Blood and Marrow Transplantation (EBMT).	16193083
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Results of reduced intensity conditioning regimen (RIC) in the HLA identical haematopoietic stem cell transplantation (HSCT) setting have not been compared to those after myeloablative (MA) regimen HSCT in patients with acute myeloblastic leukaemia (AML) over 50 years of age.	16193083
physiopathological, Neuropathy	Stem Cell Exhaustion	High dose melphalan and autologous stem cell transplantation did not ameliorate neuropathy or diaphragm dysfunction.	16194876
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Augmented high-dose regimen of cyclophosphamide, carmustine, and etoposide with autologous hematopoietic stem cell transplantation for relapsed and refractory aggressive non-Hodgkin's lymphoma.	16194894
Failure, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Progressive disease is the major cause of treatment failure after autologous hematopoietic stem cell transplantation for relapsed or refractory non-Hodgkin's lymphoma.	16194894
Heart Neoplasm, Lymphoma, vena caval syndrome	Stem Cell Exhaustion	Malignant lymphoma presenting as a cardiac tumor and superior vena caval syndrome successfully treated by haploidentical stem cell transplantation.	16194899
B-Cell Lymphomas, Heart Neoplasm	Stem Cell Exhaustion	A 16 year-old male with B-cell non-Hodgkin's lymphoma presenting as a cardiac tumor and superior vena caval (SVC) syndrome received a haploidentical stem cell transplant (SCT) from his mother after conventional and salvage chemotherapy.	16194899
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	The present study was conducted to explore the potential of human umbilical cord blood (UCB) CD133+ progenitor cells for myocardial tissue repair in a model of extensive myocardial infarction (MI).	16195418
B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1	Stem Cell Exhaustion	Treatment of relapsed blast-phase Philadelphia-chromosome-positive leukaemia after non-myeloablative stem-cell transplantation with donor lymphocytes and imatinib.	16198987
Niemann-Pick Diseases	Stem Cell Exhaustion	Successful hematopoietic stem cell transplantation for Niemann-Pick disease type B. Histocompatible hematopoietic stem cell transplantation (HSCT) was conducted on a 4.5-year-old girl with Niemann-Pick disease type B.	16199719
S100A4 protein, human, Somatic mutation	Stem Cell Exhaustion	These findings suggest a somatic mutation, probably in a stem cell common to the myeloid lineage of both patients, and indicate that patient A may undergo malignant transformation in the future.	16201732
leukemia	Stem Cell Exhaustion	Myelomastocytic leukemia: evidence for the origin of mast cells from the leukemic clone and eradication by allogeneic stem cell transplantation.	16203765
Hodgkin Disease, Neoplasms	Stem Cell Exhaustion	High-dose therapy and autologous hematopoietic stem-cell transplantation does not increase the risk of second neoplasms for patients with Hodgkin's lymphoma: a comparison of conventional therapy alone versus conventional therapy followed by autologous hematopoietic stem-cell transplantation.	16204014
Hodgkin Disease, Malignant Neoplasms, LIPC gene	Stem Cell Exhaustion	To determine the incidence of second malignancies among patients with Hodgkin's lymphoma (HL) treated with autologous hematopoietic stem cell transplantation (AHSCT) compared with patients receiving conventional therapy alone and to identify potential risk factors for their occurrence.	16204014
Lymphoma, Follicular	Stem Cell Exhaustion	Long-term event-free survivors after high-dose therapy and autologous stem-cell transplantation for low-grade follicular lymphoma.	16205727
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Imatinib synergizes with donor lymphocyte infusions to achieve rapid molecular remission of CML relapsing after allogeneic stem cell transplantation.	16205732
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Donor lymphocyte infusions (DLI) have been the mainstay of treatment for chronic myeloid leukemia (CML) relapsing after allogeneic stem cell transplantation (allo-SCT).	16205732
Lymphoma, Follicular	Stem Cell Exhaustion	Cicatricial pemphigoid of the oropharynx after allogeneic stem cell transplantation for relapsed follicular lymphoma.	16207603
Lymphoma, Follicular	Stem Cell Exhaustion	A 44-year-old woman with refractory follicular lymphoma underwent allogeneic stem cell transplantation (SCT) and achieved complete remission.	16207603
Glomerulonephritis, Chronic graft-versus-host disease	Stem Cell Exhaustion	Antineutrophil cytoplasmic antibody-associated glomerulonephritis in chronic graft-versus-host disease after allogenic hematopoietic stem cell transplantation.	16213351
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GVHD) is one of the most frequent complications that occur after hematopoietic stem cell transplantation (HSCT).	16213351
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Following preparation with chemotherapy, a 29-year-old man with chronic myeloid leukemia underwent allogenic peripheral blood stem cell (PBSC) transplantation, after which first acute and then chronic GVHD developed.	16213351
Restenosis	Stem Cell Exhaustion	We hypothesized that changes in the peripheral progenitor cell counts after coronary stenting may predict the development of restenosis.	16214449
Adult Myelodysplastic Syndrome, Cytopenia, Acute leukemia	Stem Cell Exhaustion	Myelodysplastic syndrome is a clonal hematopoietic stem cell disorder characterized by ineffective hematopoiesis, peripheral cytopenias and an additional risk to evolve to acute leukemia in up to 30% of the cases.	16219353
Decreased platelet count	Stem Cell Exhaustion	Family members were studied as potential stem cell donors, revealing that both younger siblings displayed significant thrombocytopenia, whereas both parents had normal blood counts.	16219544
Diabetic Foot	Stem Cell Exhaustion	[Rapid healing of a therapy-refractory diabetic foot after transplantation of autologous bone marrow stem cells].	16220257
Diabetic Foot	Stem Cell Exhaustion	The combined intraarterial and intramuscular transplantation of autologous bone marrow stem cells could constitute a novel, clinically feasible and safe therapy for patients with diabetic foot syndrome.	16220257
Childhood Breast Carcinoma	Stem Cell Exhaustion	Main indices of efficacy such as objective response and stabilization frequency, objective response median and survival rate were evaluated in 84 patients with disseminated breast cancer receiving different doses of cytostatics: high-dose chemotherapy (HDC) plus transplantation of peripheral blood stem cells, standard-dose (SDC), dose reduced by 20% (RDC20) or by 50% (RDC50).	16222999
Restenosis, Acute myocardial infarction	Stem Cell Exhaustion	Granulocyte--colony-stimulating factor administered for autologous hematopoietic stem cell isolation from blood may favor restenosis in patients implanted after acute myocardial infarction (AMI).	16223854
Medial collateral ligament	Stem Cell Exhaustion	These results suggest that this schedule may have notable antitumour activity in patients with MCL, including patients in relapse after autologous stem cell transplantation.	16225653
BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 20	Stem Cell Exhaustion	RhoA, Rho kinase, JAK2, and STAT3 may be the intracellular determinants of longevity implicated in the progeric influence of obesity: Insulin, IGF-1, and leptin may all conspire to promote stem cell exhaustion.	16226846
BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 20	Stem Cell Exhaustion	The implications of these recent determinations, in light of the recent finding of telomere attrition in humans associated with obesity, are that the intracellular determinants of aging may already be known, and the known common influence of these signaling elements on longitudinal stem cell dynamics is a pronounced induction of proliferation, an elevation that has been linked to the pathologic evolution of longitudinal organ-level dysfunction and the organismal-level physiologic decline seen with the inexorable passage of time.	16226846
Multiple Myeloma	Stem Cell Exhaustion	We performed a randomized phase 1/2 study in lymphopenic individuals after high-dose chemotherapy and autologous hematopoietic stem cell transplantation for myeloma.	16227990
Aspergillosis	Stem Cell Exhaustion	Invasive aspergillosis of the central nervous system after allogeneic stem cell transplantation.	16230206
Central Nervous System, Pregnancy Complications, Infectious	Stem Cell Exhaustion	Central nervous system aspergillosis is a rare infectious complication in patients submitted to allogeneic stem cell transplantation.	16230206
Kidney Failure, Infertility	Stem Cell Exhaustion	Autologous stem cell transplantation and cisplatin- and MOPP (mechlorethamine/vincristine/procarbazine/prednisone)-containing therapies were associated with infertility and renal insufficiency.	16231850
Cardiovascular system	Stem Cell Exhaustion	Cardiovascular toxicity is increased, but manageable, during high-dose chemotherapy and autologous peripheral blood stem cell transplantation for patients aged 60 years and older.	16236612
Encephalopathy, CTCAE 5.0, Seizures	Stem Cell Exhaustion	Recurrent seizure and sustained encephalopathy associated with dimethylsulfoxide-preserved stem cell infusion.	16236621
Lymphoma	Stem Cell Exhaustion	We report the case of a patient who received two infusions of dimethylsulfoxide (DMSO) cryopreserved autologous peripheral blood progenitor cells (PBPCs) after myeloablative chemotherapy for a relapsing lymphoma.	16236621
Small cell carcinoma of lung	Stem Cell Exhaustion	Double-cycle, high-dose ifosfamide, carboplatin, and etoposide followed by peripheral blood stem-cell transplantation for small cell lung cancer.	16236883
Small cell carcinoma of lung	Stem Cell Exhaustion	To determine the tolerability and feasibility of double-cycle, high-dose chemotherapy followed by peripheral blood stem-cell transplantation (PBSCT) after conventional chemotherapy or chemoradiotherapy for small cell lung cancer (SCLC).	16236883
Chronic heart failure	Stem Cell Exhaustion	Granulocyte colony-stimulating factor-induced blood stem cell mobilisation in patients with chronic heart failure--Feasibility, safety and effects on exercise tolerance and cardiac function.	16237506
Chronic heart failure, Doctor of Chiropractic, Ischemic cardiomyopathy, between breakfast and lunch	Stem Cell Exhaustion	In order to test whether an increase in circulating stem cell numbers improves impaired myocardial function we treated 16 male patients with chronic heart failure due to dilated (DCM; n = 7) or ischaemic cardiomyopathy (ICM; n = 9) with the stem cell mobilising cytokine granulocyte colony-stimulating factor (G-CSF; four 10-day treatment periods interrupted by treatment-free intervals of equal length).	16237506
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Identification of vascular progenitor cells in pulmonary arteries of patients with chronic obstructive pulmonary disease.	16239642
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	To what extent progenitor cells may play a role in vascular changes occurring in patients with chronic obstructive pulmonary disease (COPD) remains undetermined.	16239642
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	In this study we sought to identify vascular progenitor cells in pulmonary arteries of patients with COPD and to investigate whether the presence of these cells could be related to changes in endothelial function or the expression of VEGF.	16239642
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	We conclude that patients with COPD show an increased number of bone marrow-derived progenitor cells in pulmonary arteries.	16239642
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation followed by consolidation chemotherapy for patients with multiple myeloma.	16247422
Multiple Myeloma	Stem Cell Exhaustion	Although high-dose therapy and autologous stem cell transplant (ASCT) is superior to conventional chemotherapy for treatment of myeloma, most patients relapse and the time to relapse depends upon the initial prognostic factors.	16247422
Multiple Myeloma	Stem Cell Exhaustion	We prospectively studied the role of consolidation chemotherapy (CC) after single autologous peripheral blood stem cell transplant (auto-PBSCT) in 103 mostly newly diagnosed myeloma patients (67 patients were < or =6 months from the initial treatment).	16247422
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The early referral for reduced-intensity stem cell transplantation in patients with Ph1 (+) chronic myelogenous leukemia in chronic phase in the imatinib era: results of the Latin American Cooperative Oncohematology Group (LACOHG) prospective, multicenter study.	16247424
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Using a reduced-intensity stem cell transplantation (RIST) schedule, 24 patients with Philadelphia (Ph1) (+) chronic myelogenous leukemia (CML) in first chronic phase (CP) were prospectively allografted in four Latin American countries: Mexico, Brazil, Colombia and Venezuela, using HLA-identical siblings as donors.	16247424
Cardiotoxicity, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Very acute cardiac toxicity during BEAC chemotherapy in non-Hodgkin's lymphoma patients undergoing autologous stem cell transplantation.	16247436
Hepatic Veno-Occlusive Disease, Venoocclusive disease	Stem Cell Exhaustion	Hepatic veno-occlusive disease (VOD) is a severe complication of hematopoietic stem cell transplantation (SCT).	16247437
Chronic active Epstein-Barr virus infection, Hematopoietic stem cells	Stem Cell Exhaustion	Successful umbilical cord blood transplantation for severe chronic active Epstein-Barr virus infection after the double failure of hematopoietic stem cell transplantation.	16247742
CERVICAL MOTION TENDERNESS	Stem Cell Exhaustion	We have generated a mouse model for CMT type 4B1 using embryonic stem cell technology.	16249189
Agammaglobulinemia	Stem Cell Exhaustion	[Successful treatment of agammaglobulinemia by HLA-mismatched unrelated cord blood stem cell transplantation--the first case report].	16251019
X-linked agammaglobulinemia	Stem Cell Exhaustion	To evaluate cord blood stem cell transplantation (CBT) in the treatment of X-linked agammaglobulinemia, and observe the courses of the hematopoietic and immune reconstitution.	16251019
Alveolar rhabdomyosarcoma	Stem Cell Exhaustion	Poor outcome of two children with relapsed state stage IV alveolar rhabdomyosarcoma after allogeneic stem cell transplantation.	16251176
Alveolar rhabdomyosarcoma	Stem Cell Exhaustion	The authors report on 2 boys, 11(1/2) and 13 years old, who received allogeneic stem cell transplantation (alloSCT) from their HLA-identical sibling after relapse of stage IV alveolar rhabdomyosarcoma.	16251176
Precursor cell lymphoblastic lymphoma	Stem Cell Exhaustion	A 19-year-old male patient underwent hematopoietic stem cell transplantation (HSCT) from his HLA-matched brother for lymphoblastic lymphoma in the first complete remission.	16252186
Myocardial Revascularization, Ischemia	Stem Cell Exhaustion	Cytokine mobilization of progenitor cells from bone marrow may promote myocardial neovascularization with relief of ischemia.	16256862
Coronary Arteriosclerosis	Stem Cell Exhaustion	Patients with coronary artery disease (CAD) have low numbers of endothelial progenitor cells compared with healthy subjects.	16256862
Ischemia	Stem Cell Exhaustion	Progenitor cells were measured by flow cytometry; ischemia was assessed by exercise stress testing and by dobutamine stress cardiac magnetic resonance imaging.	16256862
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Stem cell therapy may be useful in chronic myocardial infarction (MI); this is conceivable, but not yet demonstrated in humans.	16256864
Membranoproliferative Glomerulonephritis, Type II	Stem Cell Exhaustion	High dose chemotherapy and stem cell support in a patient of light- and heavy-chain deposition disease with abnormal marrow cell surface antigens and no monoclonal protein.	16258214
Somatic mosaicism, Disease	Stem Cell Exhaustion	The fact that neuronal stem cells can be identified in adult humans and that somatic mosaicism may be found in neuronal precursor cells deserves further investigation before using adult neural stem cells to treat human disease.	16258289
Communicable Diseases, Scopulariopsis brevicaulis, Aspergillosis	Stem Cell Exhaustion	Breakthrough invasive infection due to Debaryomyces hansenii (teleomorph Candida famata) and Scopulariopsis brevicaulis in a stem cell transplant patient receiving liposomal amphotericin B and caspofungin for suspected aspergillosis.	16258877
Aspergillus, Pulmonary Infiltrate	Stem Cell Exhaustion	An allogeneic stem cell transplant recipient developed pulmonary infiltrates and Aspergillus antigenemia during prophylactic low-dose liposomal amphotericin B.	16258877
Neoplasms	Stem Cell Exhaustion	The tumor may have derived from a mesenchymal stem cell that had undergone partial rhabdomyomatous differentiation.	16259116
Hodgkin Disease, Toxic effect, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	This study assessed efficacy, optimal dosage and timing, and toxicity of involved-field radiotherapy used in conjunction with high-dose chemotherapy and stem cell transplantation for patients with refractory/relapsed Hodgkin's disease and non-Hodgkin's lymphoma.	16259874
Hodgkin Disease, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	The other 265 patients with refractory/relapsed non-Hodgkin's lymphoma and Hodgkin's disease received high-dose chemotherapy/stem cell transplantation, but not involved-field radiotherapy.	16259874
Cessation of life	Stem Cell Exhaustion	Data were analyzed using Cox proportional hazards regression to determine the risk of death among patients treated with stem cell transplantation compared with that among patients treated with stem cell transplantation and involved-field radiotherapy.	16259874
Hodgkin Disease, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Multivariate analysis found that patients who did not receive involved-field radiotherapy were 2.09 times more likely to die during the follow-up period than patients who received involved-field radiotherapy (P = 0.066; adjusted for age, stem cell transplantation type, stage I/II vs stage III/IV, refractory vs relapsed, and Hodgkin's disease vs non-Hodgkin's lymphoma).	16259874
Multiple Myeloma, Decreased platelet count	Stem Cell Exhaustion	Severe thrombocytopenia due to host-derived anti-HPA-1a after non-myeloablative allogeneic haematopoietic stem cell transplantation for multiple myeloma: a case report.	16262760
Decreased platelet count	Stem Cell Exhaustion	Host- or donor-derived alloimmune thrombocytopenia can develop after non-myeloablative allogeneic haematopoietic stem cell transplantation (HSCT).	16262760
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	IMVP-16/Pd followed by high-dose chemotherapy and autologous stem cell transplantation as a salvage therapy for refractory or relapsed peripheral T-cell lymphomas.	16263576
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	The present study aimed to analyse the treatment outcome of IMVP-16/Pd (ifosfamide, methotrexate, etoposide and prednisone) followed by high-dose chemotherapy and autologous stem cell transplantation (HDC/ASCT) for patients with peripheral T-cell lymphomas (PTCLs) who were previously treated with CHOP.	16263576
Erythema, Exanthema, Bulla, Edema	Stem Cell Exhaustion	We report the case of a 45-year-old man with progressive follicular large cell lymphoma following an autologous stem cell transplant treated with denileukin diftitox who developed a fatal skin rash associated with extensive erythema, edema and large bullae involving his entire body.	16263585
Combined immunodeficiency	Stem Cell Exhaustion	Polyethylene glycol-conjugated adenosine deaminase (PEG-ADA) provides an alternate therapy to mismatched stem cell transplantation for patients with ADA-deficient severe combined immunodeficiency.	16263974
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Should rituximab be used prior to autologous stem-cell transplantation for non-Hodgkin's lymphoma?	16264876
altretamine/cisplatin/cyclophosphamide protocol	Stem Cell Exhaustion	[The relationship between circulating endothelial progenitor cells and the risk factors of CHD as well as the severity of coronary lesions, and its clinical significance].	16266451
Coronary Lesions Treated, Coronary heart disease, altretamine/cisplatin/cyclophosphamide protocol	Stem Cell Exhaustion	To investigate the correlation between circulating endothelial progenitor cells (EPCs) and the risk factors of coronary heart disease (CHD) as well as the severity of coronary lesions, and its clinical significance.	16266451
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Resistance to chemotherapy in AML can be identified by gene-expression profiling before treatment and seems to be mediated by a transcriptional program active in hematopoietic stem/progenitor cells.	16266895
Primary graft failure	Stem Cell Exhaustion	These data have implications for the choice of donor and stem cell source in transplants performed using reduced intensity conditioning regimens, suggesting that the use of bone marrow, female donors and HLA-mismatched grafts increase the risk of primary graft failure, and should be avoided in certain situations.	16266905
Primary graft failure, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Primary graft failure was significantly associated with the use of a mismatched donor (6/47,13% versus 1/93, 1%, p=0.006), as well as: bone marrow as the source of stem cells (p=0.046), chronic myeloid leukemia compared to other diagnoses (p=0.022), and a female rather than a male donor (p=0.019).	16266905
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Post-transplantation lymphoproliferative disorder of recipient origin in a boy with acute T-cell leukemia with detection of B-cell clonality 3 months before stem cell transplantation.	16266918
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Post-transplantation lymphoproliferative disorder is an infrequent complication after hematopoietic stem cell transplantation.	16266918
Leukemia, T-Cell, Lymphoproliferative Disorders	Stem Cell Exhaustion	Here, we describe an 8-year old boy with early onset post-transplantation lymphoproliferative disorder following matched-unrelated stem cell transplantation for high-risk T-cell leukemia whose disease was unusual for two reasons.	16266918
Leukemia, T-Cell	Stem Cell Exhaustion	Secondly, using clonal analysis, we could retrospectively show that the B-cell clone emerged during consolidation chemotherapy for T-cell leukemia, 3 months before stem cell transplantation.	16266918
Gastric Antral Vascular Ectasia	Stem Cell Exhaustion	Gastric antral vascular ectasia in 2-yr-old girl undergoing unrelated cord blood stem cell transplantation.	16269052
Graft-vs-Host Disease, Gastrointestinal Hemorrhage	Stem Cell Exhaustion	Gastrointestinal bleeding is a common complication after hematopoietic stem cell transplantation (HSCT) and is often related to acute graft-vs.-host disease (aGVHD).	16269052
Agave, Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	We report a 2-yr-old girl who developed GAVE after unrelated cord blood stem cell transplantation (CBSCT) as treatment of intractable Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH).	16269052
Juvenile Myelomonocytic Leukemia, Failure	Stem Cell Exhaustion	Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is the only cure for juvenile myelomonocytic leukaemia (JMML), but relapse remains the major cause of failure.	16269054
Amyloidosis	Stem Cell Exhaustion	Peripheral blood progenitor cell mobilization and collection in 42 patients with primary systemic amyloidosis.	16271097
Amyloidosis	Stem Cell Exhaustion	High-dose chemotherapy followed by an inoculum of autologous peripheral blood progenitor cells (PBPCs) can improve survival in patients affected with primary systemic amyloidosis (AL).	16271097
Ischemia	Stem Cell Exhaustion	The treatment of advanced chronic lower limb ischaemia with marrow stem cell autotransplantation.	16273471
Peripheral Arterial Diseases	Stem Cell Exhaustion	The results of marrow stem cell therapy as a potential novel approach to peripheral artery disease management were presented in 2002 by Tateishi-Yuyamy.	16273471
Ischemia	Stem Cell Exhaustion	To assess efficacy and safety of critical lower limb ischaemia treatment with marrow stem cell autotransplantation.	16273471
Ischemic	Stem Cell Exhaustion	Marrow stem cell autotransplantation into the ischaemic lower limb seems to be a potentially effective method of peripheral perfusion enhancement.	16273471
Pregnancy Complications, Infectious	Stem Cell Exhaustion	Fluoroquinolone resistance in hematopoietic stem cell transplant recipients with infectious complications.	16274955
Pregnancy Complications, Infectious	Stem Cell Exhaustion	The infectious complications are an important cause of morbidity and mortality in hematopoietic stem cell transplant (HSCT) recipients.	16274955
Hemolytic-Uremic Syndrome	Stem Cell Exhaustion	Hemolytic uremic syndrome (HUS) is an uncommon but potentially life-threatening complication of hematopoietic stem cell transplantation.	16275594
Multiple Myeloma	Stem Cell Exhaustion	High-dose therapy and autologous blood stem-cell transplantation compared with conventional treatment in myeloma patients aged 55 to 65 years: long-term results of a randomized control trial from the Group Myelome-Autogreffe.	16275936
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	To study the impact of high-dose therapy (HDT) with autologous stem-cell support in patients with symptomatic multiple myeloma (MM) between the ages of 55 and 65 years.	16275936
Rheumatoid Arthritis, Adult Glioblastoma	Stem Cell Exhaustion	Two stem/progenitor cell neurosphere and two glioblastoma spheroid cultures were initiated to differentiate using RA and cAMP.	16278045
Adult Glioblastoma	Stem Cell Exhaustion	The expression of CCR5 was the highest one on the 3rd day of differentiation in all cultures, but showed also distinct differences between cultures, and in normal fetal differentiated stem/progenitor cells the expression of CCR5 was much weaker than in differentiated glioblastoma spheric cells.	16278045
Neoplasms	Stem Cell Exhaustion	Mesenchymal stem cell targeting of microscopic tumors and tumor stroma development monitored by noninvasive in vivo positron emission tomography imaging.	16278396
Neoplasms	Stem Cell Exhaustion	Subsequently, these tumors were examined for specificity and magnitude of HSV1-TK(+), EGFP(+) stem cell engraftment and proliferation in tumor stroma by in vivo positron emission tomography (PET) with (18)F-labeled 9-(4-fluoro-3-hydroxymethylbutyl)-guanine ([(18)F]-FHBG).	16278396
Neoplasms	Stem Cell Exhaustion	PET imaging should facilitate clinical translation of stem cell-based anticancer gene therapeutic approaches by providing the means for in vivo noninvasive whole-body monitoring of trafficking, tumor targeting, and proliferation of HSV1-tk-expressing "tracer" hMSCs in tumor stroma.	16278396
Neoplasms	Stem Cell Exhaustion	The aim of this study was to assess the efficacy human mesenchymal stem cells (hMSC) for targeting microscopic tumors and suicide gene or cytokine gene therapy.	16278396
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Absolute lymphocyte count (ALC) recovery postautologous stem cell transplantation is an independent predictor for survival in acute myelogenous leukemia (AML).	16281063
Communicable Diseases	Stem Cell Exhaustion	Cytomegalovirus (CMV) infection is a major complication for patients who received allogeneic haematopoietic stem cell transplantation (HSCT).	16281937
Persistent CMV viremia	Stem Cell Exhaustion	Quantitative polymerase chain reaction (QPCR) for cytomegalovirus (CMV) is emerging as the preferred screening method for detection of CMV viremia in patients following allogeneic bone marrow and peripheral blood stem cell transplant.	16284613
Persistent CMV viremia	Stem Cell Exhaustion	We conclude delaying pre-emptive therapy with ODG until whole blood QPCR> or =10 000 copies/ml is a safe and effective strategy for CMV viremia after allogeneic stem cell transplant in clinically stable patients.	16284613
Hematologic Neoplasms	Stem Cell Exhaustion	A randomized, double blind comparative study of prophylactic parenteral nutritional support with or without glutamine in autologous stem cell transplantation for hematological malignancies -- three years' follow-up.	16284692
Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Estimating late adverse events using competing risks after autologous stem-cell transplantation in aggressive non-Hodgkin lymphoma patients.	16284986
Lymphoma, Non-Hodgkin, Familial, Toxic effect, T-Cell Lymphoma	Stem Cell Exhaustion	Consolidative autologous stem-cell transplantation (ASCT) is a valuable option in high-risk or disease recurrence large-cell non-Hodgkin lymphoma patients (NHL); however, its long-term toxicity must still be assessed.	16284986
Amyloidosis	Stem Cell Exhaustion	Indications for high-dose chemotherapy with autologous stem cell support in patients with systemic amyloid light chain amyloidosis.	16286897
Alopecia	Stem Cell Exhaustion	This is in contrast with inflammatory non-scarring alopecias such as alopecia areata, where the bulb region is targeted, sparing the stem cells.	16293179
Multiple Myeloma	Stem Cell Exhaustion	Double autologous stem cell transplantation for multiple myeloma: a Korean single center study.	16295783
Multiple Myeloma	Stem Cell Exhaustion	Although high dose chemotherapy coupled with an autologous stem cell transplantation (ASCT) is widely accepted as effective therapy for multiple myeloma (MM), few reports are available in Korea, especially in the area of double ASCT.	16295783
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myelogenous leukemia (CML) is a malignant clonal disorder of hemopoietic stem cells characterized by abnormal proliferation and accumulation of immature granulocyte.	16295787
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 29-year-old man received an autologous stem cell transplantation after myeloablation with busulfan and cyclophosphamide to treat his acute myeloid leukemia, a.	16296155
Graft vs Host Reaction	Stem Cell Exhaustion	Flexural graft-versus-host-like reactions after autologous stem cell transplantation have been reported in four patients.	16296155
Peeling of skin	Stem Cell Exhaustion	Five days after retransfusion of stem cells, hyperpigmented, scaly lesions with occasional perpheral lichenoid papules developed in groins, axillae, genitalia, and elbows.	16296155
Gastrointestinal Stromal Tumors	Stem Cell Exhaustion	Gastrointestinal stromal tumors (GISTs) are thought to originate from mesenchymal stem cells that differentiate toward the interstitial cells of Cajal (ICCs).	16297706
Adult T-Cell Lymphoma/Leukemia	Stem Cell Exhaustion	A 61-year-old man with progressive adult T-cell leukemia/lymphoma (ATLL) successfully received reduced-intensity conditioning stem cell transplantation (RIST) without T-cell depletion (TCD) from his HLA-incompatible son, who had negative results for human T-lymphotropic virus type 1 (HTLV-1) (1-locus, 1-allele mismatch in the graft-versus-host [GVH] direction; 2-loci, 1-allele mismatch in the host-versus-graft direction).	16298831
Adult T-Cell Lymphoma/Leukemia	Stem Cell Exhaustion	The results in this case suggest the potential of non-TCD RIST from an HLA-incompatible relative donor as an alternative source of hematopoietic stem cells even for an elderly patient with advanced ATLL.	16298831
Pseudohyponatremia, Hypercholesterolemia	Stem Cell Exhaustion	Severe hypercholesterolemia associated with decreased hepatic triglyceride lipase activity and pseudohyponatremia in patients after allogeneic stem cell transplantation.	16298832
Primary Induction Failure, B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative	Stem Cell Exhaustion	A 55-year-old woman with Ph-negative acute lymphoblastic leukemia in primary induction failure received allogeneic peripheral blood stem cell transplantation from her HLA-compatible sister.	16298832
Therapy-Related Acute Myeloid Leukemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Autologous stem cell transplantation for therapy-related acute myeloid leukemia and myelodysplastic syndrome.	16299545
Mycoses	Stem Cell Exhaustion	Because of the high risk of fatal recurrence of the fungal infection, neither long-term maintenance chemotherapy nor allogeneic hematopoietic stem cell transplant (HSCT) was considered appropriate.	16302216
Acute lymphocytic leukemia	Stem Cell Exhaustion	Autologous transplantation of CD133 selected hematopoietic progenitor cells for treatment of relapsed acute lymphoblastic leukemia.	16302216
Giant Cell Fibroblastoma, Muscle (organ)	Stem Cell Exhaustion	Although the cellular origin of DFSP is not entirely clear, dermal stem cells or undifferentiated mesenchymal cells with fibroblastic, muscular, and neuroectodermal features have been implicated.	16302562
Neoplasms	Stem Cell Exhaustion	Some cells (12%) were CD34 positive, indicating the presence within the tumor of hematopoietic stem cells.	16302618
Anemia, Diamond-Blackfan	Stem Cell Exhaustion	Allogeneic peripheral blood stem cell transplant (PBSCT) using anti-IL2 receptor antibody Daclizumab for the prevention of acute graft versus host disease in steroid refractory Diamond Blackfan anaemia: a case report.	16304857
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic hematopoietic stem-cell transplantation in AML and MDS using myeloablative versus reduced-intensity conditioning: the role of dose intensity.	16307018
Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic stem-cell transplantation (SCT) with both myeloablative and reduced-intensity conditioning (RIC) is an effective therapy in AML/MDS.	16307018
Congestive heart failure	Stem Cell Exhaustion	Surgical treatment for congestive heart failure with autologous adult stem cell transplantation: a prospective randomized study.	16308009
Ischemic cardiomyopathy	Stem Cell Exhaustion	After institutional review board and government approval, adult autologous stem cell transplantation (CD34+) was performed in patients with ischemic cardiomyopathy and an ejection fraction of less than 35% who were scheduled for primary off-pump coronary artery bypass grafting.	16308009
Ischemic cardiomyopathy	Stem Cell Exhaustion	Autologous stem cell transplantation led to significant improvement in cardiac function in patients undergoing off-pump coronary artery bypass grafting for ischemic cardiomyopathy.	16308009
Congestive heart failure	Stem Cell Exhaustion	A randomized study was conducted with a novel epicardial technique to deploy stem cells as an adjuvant to conventional revascularization therapy in patients with congestive heart failure.	16308009
Dry Eye Syndromes	Stem Cell Exhaustion	Corneal grafts or limbal stem cell transplantation are often unsuccessful in patients with severe ocular surface disorders such as severe dry eye syndrome, symblepharon or diffuse vascularisation.	16308693
Epithelial, Burn injury, Infiltration	Stem Cell Exhaustion	Severe alkali burns lead to massive limbal stem cell damage resulting in persistent epithelial defects, infiltration and stromal melting early in the disease process.	16308824
Supratentorial, Neoplasms, Medulloblastoma	Stem Cell Exhaustion	It is of particular interest that we have previously reported that the progenitor cell-associated NG2 heparan sulphate proteoglycan was not expressed in a series of medulloblastoma biopsy sections in our laboratories, while NG2 positivity was seen in supratentorial primitive neuro-ectodermal tumours (PNETs).	16309171
Aplastic Anemia, Hematopoietic	Stem Cell Exhaustion	Aplastic anemia (AA) is a syndrome of hematopoietic failure involving increased apoptosis of stem cells.	16310248
PAFAH1B1 wt Allele, Tumor necrosis, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	An excessive intramedullar progenitor cell apoptosis, to which elevated expression of tumor necrosis factor-alpha (TNF-alpha) might contribute, is considered the main cause of inefficient hematopoiesis in myelodysplastic syndromes (MDS).	16313260
Anemia, PAFAH1B1 wt Allele, Hyperplasia	Stem Cell Exhaustion	TNF-alpha expression in BM progenitor cells appears to negatively impact erythropoiesis and overall survival in MDS, and may serve as a potential therapeutic target in patients with hypercellular MDS with marked anemia.	16313260
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We evaluated the count of resting (rCEC), activated (aCEC) and endothelial progenitor cells (CEPC) in the PB of AML and healthy subjects.	16313261
Anemia, Hypoalbuminemia	Stem Cell Exhaustion	Univariate analysis revealed adverse prognostic factors: FHIT gene methylation (P = 0.028), poor performance status (I to IV, P = 0.002), anemia (< or =8.5 g/dL, P = 0.007), hypoalbuminemia (< or =3.5 g/dL, P < 0.002), high serum C-reactive protein levels (>0.5 mg/dL, P = 0.002), elevated beta-2-microglobulin serum levels (>6.5 mg/L, P < 0.001), and treatments not including autologous peripheral blood stem cell transplantation (auto-PBSCT) (P = 0.007).	16313263
Stable chronic Graft vs Host Disease	Stem Cell Exhaustion	Chronic graft-vs.-host disease (cGVHD) occurs in 20-50% of patients who survive for at least 100 d after allogeneic stem cell transplantation (SCT).	16313267
Fatigue, Hematologic	Stem Cell Exhaustion	Clinical factors associated with fatigue in haematologic cancer patients receiving stem-cell transplantation.	16314087
Fatigue, Specialty Type - cancer	Stem Cell Exhaustion	We have evaluated risk factors associated with fatigue in 220 cancer patients during hospitalization for stem-cell transplantation (SCT).	16314087
Specialty Type - cancer	Stem Cell Exhaustion	An ability to count lifetime numbers of stem cell divisions covertly recorded by random replication errors provides new opportunities to link cell proliferation with aging and cancer.	16314580
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic stem-cell transplantation using a reduced-intensity conditioning regimen has the capacity to produce durable remissions and long-term disease-free survival in patients with high-risk acute myeloid leukemia and myelodysplasia.	16314618
Toxic effect	Stem Cell Exhaustion	The toxicity of allogeneic stem-cell transplantation can be substantially reduced using a reduced-intensity conditioning (RIC) regimen.	16314618
Xerostomia, Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease, Skin Pigmentation, Liver Dysfunction, Acute lymphocytic leukemia	Stem Cell Exhaustion	A 47-year-old man, who suffered from acute lymphocytic leukemia at 45 years old and was treated with hematopoietic stem cell transplantation at 46 years old after the induction of complete remission by the standard chemotherapy, developed the symptoms of chronic graft-versus-host disease (cGVHD) such as dry eyes, dry mouth, skin thickening, skin scaling, skin pigmentation and impaired liver function.	16318371
Hollings Cancer Center	Stem Cell Exhaustion	Expression of the platelet-derived growth factor receptor (PDGFR) has been demonstrated in HCC, which may derive from hepatic stem cells that express c-kit.	16319507
Multiple Myeloma	Stem Cell Exhaustion	Results of a phase I/II trial adding carmustine (300 mg/m2) to melphalan (200 mg/m2) in multiple myeloma patients undergoing autologous stem cell transplantation.	16319952
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation (SCT) with high-dose melphalan (HDM, 200 mg/m2) is the most effective therapy for multiple myeloma.	16319952
Neoplasms, Multiple Myeloma	Stem Cell Exhaustion	The tumor kinetics of multiple myeloma following autologous stem cell transplantation as assessed by measuring serum-free light chains.	16321823
Multiple Myeloma	Stem Cell Exhaustion	Prognostic relevance of CD56 expression in multiple myeloma: a study including 107 cases treated with high-dose melphalan-based chemotherapy and autologous stem cell transplant.	16321826
Central Nervous System, Lymphoproliferative Disorders	Stem Cell Exhaustion	Epstein-Barr virus-associated post-transplant lymphoproliferative disease with central nervous system involvement after unrelated allogeneic hematopoietic stem cell transplantation.	16321845
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Post-transplant lymphoproliferative disorders (PTLD) represent an heterogeneous group of abnormal lymphoid proliferation related to Epstein-Barr virus (EBV) reactivation that arise early after allogeneic hematopoietic stem cell transplant (HSCT).	16321845
Myeloid neoplasm	Stem Cell Exhaustion	Detection of molecular targets on the surface of CD34+/CD38-- stem cells in various myeloid malignancies.	16321850
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In acute myeloid leukemia (AML), the NOD/SCID mouse-repopulating leukemic stem cells usually co-express CD123 with CD34, but lack CD38.	16321850
Myeloid neoplasm	Stem Cell Exhaustion	In conclusion, neoplastic stem cells in various myeloid neoplasms appear to express a similar phenotype including target antigens such as CD13, CD33 and CD44.	16321850
Myeloid neoplasm	Stem Cell Exhaustion	Recent data suggest that myeloid neoplasms are organized hierarchically in terms of self-renewal and maturation of early progenitor cells, similar to normal myelopoiesis.	16321850
Primary Myelofibrosis, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Similar to other CMPDs, the stem cell in CIMF has the potential to differentiate into myeloid or lymphoid lineages, and thus CIMF can culminate in acute leukemia of myeloid or, rarely, lymphoid lineage.	16321864
Prostatic Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	We report here the identification and characterization of a cancer stem cell population from human prostate tumors, which possess a significant capacity for self-renewal.	16322242
Prostate carcinoma	Stem Cell Exhaustion	The identification of a prostate cancer stem cell provides a powerful tool to investigate the tumorigenic process and to develop therapies targeted to the stem cell.	16322242
Prostate carcinoma	Stem Cell Exhaustion	Prospective identification of tumorigenic prostate cancer stem cells.	16322242
Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	There is now increasing evidence in some malignancies that the tumor cells are organized as a hierarchy originating from rare stem cells that are responsible for maintaining the tumor.	16322242
Prostatic Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	The cancer stem cells have a CD44+/alpha2beta1hi/CD133+ phenotype, and we have exploited these markers to isolate cells from a series of prostate tumors with differing Gleason grade and metastatic states.	16322242
Myeloproliferation	Stem Cell Exhaustion	The vertebral body, an even larger reservoir of myeloproliferative cells, should provide progenitor cell concentrations similar to those of the iliac crest.	16322615
Allogeneic Hematopoietic Stem Cell Transplantation, Liver Dysfunction	Stem Cell Exhaustion	[Liver biopsy in the management of liver dysfunction after allogeneic hematopoietic stem-cell transplantation].	16324408
Liver Dysfunction	Stem Cell Exhaustion	To investigate the pathologic and clinical characteristics of patients with liver dysfunction after allogeneic hemopoietic stem cell transplantation (Allo-HSCT), and evaluate the role of liver biopsy in diagnosis and management of liver dysfunction post Allo-HSCT.	16324408
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	A 13-year-old boy with chemotherapy-resistant diffuse large B-cell lymphoma (DLBCL) was successfully treated with autologous peripheral blood stem cell transplantation (auto-PBSCT) with administration of rituximab.	16326408
Hodgkin Disease	Stem Cell Exhaustion	The role of high-dose therapy and autologous stem cell transplantation in patients with primary refractory Hodgkin's lymphoma: a report from the Gruppo Italiano per lo Studio dei Linfomi (GISL).	16327815
Multiple Myeloma	Stem Cell Exhaustion	Feasibility and outcome of tandem stem cell autotransplants in multiple myeloma.	16330437
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Clinical trials have shown that high dose chemotherapy (HDT) with peripheral stem cell autotransplantation is presently the best treatment for patients with symptomatic multiple myeloma (MM).	16330437
Multiple Myeloma	Stem Cell Exhaustion	Combination therapy with thalidomide and dexamethasone in patients with newly diagnosed multiple myeloma not undergoing upfront autologous stem cell transplantation: a phase II trial.	16330438
Multiple Myeloma	Stem Cell Exhaustion	However, many patients treated initially with Thal/Dex do not proceed to autologous stem cell transplantation (ASCT) and the time to progression and other outcome measures with Thal/Dex as primary therapy for multiple myeloma are not known.	16330438
Hematologic Neoplasms	Stem Cell Exhaustion	Despite increasing intensity and profound immunosuppression associated with newer therapies for hematologic malignancies, little information exists regarding cytomegalovirus (CMV) reactivation in settings other than allogeneic stem cell transplantation (SCT).	16330442
Abnormal vision, Photophobia, Deficiency	Stem Cell Exhaustion	To report an 8-year-old girl with bilateral progressive visual loss and photophobia secondary to stem cell deficiency as a result of multiple endocrine deficiency.	16331052
Mantle cell lymphoma	Stem Cell Exhaustion	Quantitative assessment of molecular remission after high-dose therapy with autologous stem cell transplantation predicts long-term remission in mantle cell lymphoma.	16332971
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	To evaluate the prognostic impact of minimal residual disease (MRD), quantitative real-time polymerase chain reaction (RQ-PCR) of clonal IGH rearrangements was performed in 29 patients with mantle cell lymphoma (MCL) treated with high-dose radiochemotherapy and autologous stem cell transplantation (ASCT).	16332971
Neoplasms	Stem Cell Exhaustion	The tumor could not be resected and he was successfully treated with intensive induction chemotherapy, irradiation, and high-dose chemotherapy with autologous stem cell transplantation.	16333835
Toxoplasmosis	Stem Cell Exhaustion	Disseminated toxoplasmosis resulting in graft failure in a cord blood stem cell transplant recipient.	16333839
Toxoplasmosis, Communicable Diseases	Stem Cell Exhaustion	Toxoplasmosis is an infrequent infection with a high mortality rate in hematopoietic stem cell transplant recipients, and is usually caused by reactivation of prior, latent infection upon intensive immunosuppression.	16333839
Toxoplasmosis	Stem Cell Exhaustion	Recommendations for toxoplasmosis diagnosis, treatment, and prophylaxis in stem cell transplant recipients are reviewed.	16333839
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Therapeutic agents for chronic myeloid leukaemia (CML) in the chronic phase include hydroxyurea, interferon alpha, allogeneic stem cell transplantation and the tyrosine kinase inhibitor imatinib (STI 571, Gleevec).	16336296
Thalassemia	Stem Cell Exhaustion	The review goes on to emphasize pharmaceutical efforts to induce fetal hemoglobin synthesis in thalassemic red cells and ends with a discussion of oral iron chelators, stem cell transplant, and the status of gene therapy.	16339645
Diabetes	Stem Cell Exhaustion	p53 Mediates the accelerated onset of senescence of endothelial progenitor cells in diabetes.	16339764
Hepatic Veno-Occlusive Disease	Stem Cell Exhaustion	Diagnosis of hepatic veno-occlusive disease by plasminogen activator inhibitor-1 plasma antigen levels: a prospective analysis in 350 allogeneic hematopoietic stem cell recipients.	16340778
Venoocclusive disease	Stem Cell Exhaustion	Veno-occlusive disease (VOD) is one of the most serious complications following allogeneic hematopoietic stem cell transplantation (HSCT) and is associated with a high mortality.	16340778
Amyotrophic Lateral Sclerosis, Antilymphocyte Serum	Stem Cell Exhaustion	The recent development of a rat model of amyotrophic lateral sclerosis (ALS) in which the rats harbor a mutated human SOD1 (G93A) gene has greatly expanded the range of potential experiments, because the rats' large size permits biochemical analyses and therapeutic trials, such as the intrathecal injection of new drugs and stem cell transplantation.	16342121
Coronary heart disease	Stem Cell Exhaustion	Safety and efficacy of peripheral blood progenitor cell mobilization and collection in patients with advanced coronary heart disease.	16342193
Coronary heart disease, altretamine/cisplatin/cyclophosphamide protocol	Stem Cell Exhaustion	Information on the safety of mobilization and collection of peripheral blood progenitor cells (PBPC) in patients with advanced coronary heart disease (CHD) is limited.	16342193
Small cell carcinoma of lung	Stem Cell Exhaustion	Small cell lung carcinoma (SCLC) cell lines commonly express KIT and its ligand, stem cell factor, suggesting an autocrine loop promoting cell growth.	16342249
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Treatment with cladribine, daunorubicin and cytosine arabinoside, followed by autologous stem cell transplantation, induced complete remission of AML and hematologic remission of HCL for 22 months, when he relapsed with AML.	16343277
Virus-Related Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Epstein-barr virus-related gastric adenocarcinoma: an early secondary cancer post hemopoietic stem cell transplantation.	16344071
Gastric Adenocarcinoma, Multiple Myeloma, Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation	Stem Cell Exhaustion	We studied a case of early onset gastric adenocarcinoma after nonmyeloablative hematopoietic stem cell transplantation for myeloma in a 56-year-old man.	16344071
Adenocarcinoma, Dysplasia, Gastritis	Stem Cell Exhaustion	Three sequential gastric biopsy examinations performed at 100, 130, and 150 days after hematopoietic stem cell transplantation showed gastritis, dysplasia, and adenocarcinoma, respectively.	16344071
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma.	16344273
Idiopathic pulmonary hypertension	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPCs) isolated from normal subjects or patients with IPAH were differentiated in culture for 7 days and apoptosis was determined in the presence and absence of BMPs.	16357305
Acute lymphocytic leukemia	Stem Cell Exhaustion	Autologous stem cell transplantation in adults with acute lymphoblastic leukemia in first complete remission: analysis of the LALA-85, -87 and -94 trials.	16357838
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	To evaluate the results of autologous stem cell transplantation (ASCT) in a large population of adults with acute lymphoblastic leukemia (ALL) in first complete remission (CR), we performed an individual data-based overview of the last three trials from the LALA group.	16357838
PAFAH1B1 wt Allele	Stem Cell Exhaustion	One patient with MDS proceeded to allogeneic stem cell transplantation and is alive without evidence of disease 39 months later.	16357841
Graft-vs-Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic graft-versus-host disease (GVHD) is a major limitation of successful allogeneic hematopoietic stem cell transplantation (HSCT).	16368882
Cytomegalovirus Retinitis, Acute lymphocytic leukemia	Stem Cell Exhaustion	A 13-year-old boy with acute lymphoblastic leukemia was treated for cytomegalovirus retinitis with valganciclovir 450 mg every 2 days in the course of hematopoietic stem cell transplantation.	16368917
Ocular surface disease	Stem Cell Exhaustion	A 73-year-old aniridic woman who had a failed PK complicated by ocular surface disease refused limbal stem cell transplantation and underwent repeat PK in her right eye.	16371795
Limbal stem cell deficiency	Stem Cell Exhaustion	The graft remains thin and clear with a smooth and intact epithelial surface beneath the BCL and no signs of limbal stem-cell deficiency.	16371795
Specialty Type - cancer	Stem Cell Exhaustion	We consider that morules in colonic neoplasms are cell clusters with a basal/stem cell phenotype, and have less proliferative and less invasive potential than other cancer cells.	16374071
Liver Cirrhosis, Intrahepatic Cholangiocarcinoma	Stem Cell Exhaustion	Intrahepatic cholangiocarcinoma arising in cirrhotic liver frequently expressed p63-positive basal/stem-cell phenotype.	16377099
Malignant Neoplasms	Stem Cell Exhaustion	Based on these aspects, not only HC-CC, but also other combinations of cellular phenotypes, would cover all the cancers with stem cell features.	16377099
Liver Cirrhosis	Stem Cell Exhaustion	In this study, which aimed at determining the characteristics of the ICC phenotype, we used immunohistochemistry to examine the expression of basal/stem-cell markers, i.e., p63 in ICC with and without liver cirrhosis, as well as the expressions of cytokeratin (CK) 34 beta E12, specific for the basal-cell marker, and c-kit, specific for the stem-cell marker.	16377099
Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Dose-escalated CHOP plus etoposide (MegaCHOEP) followed by repeated stem cell transplantation for primary treatment of aggressive high-risk non-Hodgkin lymphoma.	16384932
Aggressive course	Stem Cell Exhaustion	Feasibility, safety, and efficacy of a 4-course high-dose chemotherapy (HDT) protocol including autologous stem cell transplantation (SCT) after courses 2, 3, and 4 was investigated in 110 patients, aged 18 to 60 years, with primary diagnosis of aggressive NHL (aNHL), and lactic dehydrogenase (LDH) levels above normal.	16384932
Myeloproliferative disease, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myeloid leukemia (CML) is a myeloproliferative disorder of pleuripotent hematopoietic progenitor cells characterized by excessive proliferation and accumulation of granulocytes and occasionally red blood cells and platelets.	16386722
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Addition of cladribine to induction/consolidation regimen does not impair peripheral blood stem cell mobilization and bone marrow harvest for autotransplantation in acute myeloid leukemia patients.	16387150
Acute onset pain, Stomatitis	Stem Cell Exhaustion	Effectiveness of transdermal fentanyl patch for treatment of acute pain due to oral mucositis in patients receiving stem cell transplantation.	16387151
Acute onset pain, Stomatitis	Stem Cell Exhaustion	The current study was performed to evaluate the effectiveness and safety of transdermal therapeutic system (TTS) fentanyl in the management of acute pain due to oral mucositis in patients receiving stem cell transplantation.	16387151
Gastrointestinal mucositis	Stem Cell Exhaustion	The TTS fentanyl was effective in both relieving oral mucositis pain with an excellent tolerability and improving the quality of life for hematological patients receiving high-dose chemotherapy with stem cell transplantation.	16387151
Toxoplasma	Stem Cell Exhaustion	We report the screening and monitoring results of toxoplasma activity in 602 cases of hematopoietic stem cell transplantation (HSCT) in Chinese.	16387153
Respiratory Failure, Mycoses	Stem Cell Exhaustion	Successful treatment of patients with respiratory failure due to fungal infection after allogeneic hematopoietic stem cell transplantation.	16390403
Respiratory Failure, Mycoses	Stem Cell Exhaustion	The mortality rate associated with respiratory failure due to invasive fungal infections after allogeneic hematopoietic stem cell transplantation (HSCT) is exceedingly high.	16390403
Patient-Reported, Pharyngitis	Stem Cell Exhaustion	Palifermin reduces patient-reported mouth and throat soreness and improves patient functioning in the hematopoietic stem-cell transplantation setting.	16391299
Gastrointestinal mucositis, Pharyngitis	Stem Cell Exhaustion	To describe patient-reported outcomes of mouth and throat soreness (MTS) and related sequelae on daily activities from a phase III study of palifermin in the autologous hematopoietic stem-cell transplantation (HSCT) setting and to compare patient self-evaluations with clinicians' assessments of oral mucositis using objective scales.	16391299
Cervical Intraepithelial Neoplasia, Chronic idiopathic neutropenia	Stem Cell Exhaustion	The levels of soluble c-kit ligand (sKL), also known as Steel factor or stem cell factor, were measured in blood serum and long-term bone marrow culture supernatants of 81 patients with chronic idiopathic neutropenia (CIN) and 22 normal controls using a commercially available enzyme-linked immunosorbent assay (ELISA).	16391909
Carcinoma	Stem Cell Exhaustion	These findings are consistent with the theory that both of the carcinoma components originated from a common pluripotent stem cell.	16394290
Aggressive course	Stem Cell Exhaustion	To improve the outcome of patients with refractory aggressive NHL not suitable for High Dose Therapy (HDT) and Autologous Stem Cell Transplant (ASCT), the efficacy of a combination of gemcitabine, vinorelbine, procarbazine and prednisone (ViGePP) were tested.	16396771
Multiple Myeloma	Stem Cell Exhaustion	Prospective comparison of autologous stem cell transplantation followed by dose-reduced allograft (IFM99-03 trial) with tandem autologous stem cell transplantation (IFM99-04 trial) in high-risk de novo multiple myeloma.	16397129
Peripheral Stem Cell Transplantation, Amyloidosis	Stem Cell Exhaustion	Absolute values of immunoglobulin free light chains are prognostic in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation.	16397135
Spermatocytic seminoma, Multiple Cancer Sites	Stem Cell Exhaustion	Although the seminomas/dysgerminomas were characterized by expression of stem cell-specific genes (e.g., POU5F1, PROM1/CD133, and ZFP42), spermatocytic seminomas expressed multiple cancer testis antigens, including TSP50 and CTCFL (BORIS), as well as genes known to be expressed specifically during prophase meiosis I (TCFL5, CLGN, and LDHc).	16397242
Refractory anaemia with excess blasts	Stem Cell Exhaustion	The WHO classification is useful for diagnosis and provides risk stratification, supported by cytogenetic data for clinical decision making, identifying those RAEB patients with an unfavourable prognosis who should be offered chemotherapy or stem cell transplantation.	16398650
Fever	Stem Cell Exhaustion	Granulocyte-colony-stimulating factor-mobilized prophylactic granulocyte transfusions given after allogeneic peripheral blood progenitor cell transplantation result in a modest reduction of febrile days and intravenous antibiotic usage.	16398726
Graft-vs-Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Acute and chronic graft-versus-host disease (GVHD) continue to be major limitations to successful hematopoietic stem cell transplantation.	16399600
Febrile Neutropenia, Acute leukemia	Stem Cell Exhaustion	Piperacillin/tazobactam vs ceftazidime in the treatment of neutropenic fever in patients with acute leukemia or following autologous peripheral blood stem cell transplantation: a prospective randomized trial.	16400334
Febrile Neutropenia, Acute leukemia	Stem Cell Exhaustion	Piperacillin/tazobactam was compared with ceftazidime for the empirical treatment of febrile neutropenia in patients with acute leukemia or following autologous peripheral blood stem cell transplantation.	16400334
Graft-vs-Host Disease	Stem Cell Exhaustion	Evidence that donor intrinsic response to G-CSF is the best predictor of acute graft-vs-host disease following allogeneic peripheral blood stem cell transplantation.	16413397
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Autologous stem cell transplantation in elderly (>60 years) patients with non-Hodgkin's lymphoma: a nation-wide analysis.	16415893
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Limited experience is available on the feasibility and efficacy of autologous stem cell transplantation (ASCT) in elderly patients with non-Hodgkin's lymphoma (NHL).	16415893
PAFAH1B1 wt Allele, Secondary Acute Myeloid Leukemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Reduced-toxicity conditioning with treosulfan, fludarabine and ATG as preparative regimen for allogeneic stem cell transplantation (alloSCT) in elderly patients with secondary acute myeloid leukemia (sAML) or myelodysplastic syndrome (MDS).	16415898
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We investigated a dose-reduced conditioning regimen consisting of treosulfan and fludarabine followed by allogeneic stem cell transplantation (SCT) in 26 patients with secondary AML or MDS.	16415898
Infection	Stem Cell Exhaustion	Infections after allogeneic hematopoietic stem cell transplantation with a nonmyeloablative conditioning regimen.	16415900
Gastrointestinal mucositis, Usual Severity Pain	Stem Cell Exhaustion	Reliability and validity of a patient self-administered daily questionnaire to assess impact of oral mucositis (OM) on pain and daily functioning in patients undergoing autologous hematopoietic stem cell transplantation (HSCT).	16415901
Central nervous system complication	Stem Cell Exhaustion	Thereafter, he suffered from central nervous system complications, and successfully underwent unrelated cord blood stem cell transplantation.	16416131
Familial Hemophagocytic Lymphocytosis	Stem Cell Exhaustion	FHL may have a broad clinical spectrum, and further analysis on its phenotype-genotype association is required to establish an appropriate treatment strategy, including immunochemotherapy and stem cell transplantation in the future.	16416131
Childhood Breast Carcinoma, Neoplasms	Stem Cell Exhaustion	To compare adjuvant dose-intensive epirubicin and cyclophosphamide chemotherapy administered with filgrastim and progenitor cell support (DI-EC) with standard-dose anthracycline-based chemotherapy (SD-CT) for patients with early-stage breast cancer and a high risk of relapse, defined as stage II disease with 10 or more positive axillary nodes; or an estrogen receptor-negative or stage III tumor with five or more positive axillary nodes.	16421418
Lymphoproliferative Disorders	Stem Cell Exhaustion	EBV lymphoproliferative disease of host origin after haploidentical stem cell transplantation.	16421900
Graft-vs-Host Disease	Stem Cell Exhaustion	The risk of the disorder increases with T-cell depletion methods, mismatched hematopoietic stem cell transplantation (HSCT), graft-versus-host disease (GVHD), and immunosuppression.	16421900
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Patients with relapsed diffuse large B-cell lymphoma (DLBCL) who are either not suitable for stem cell transplantation or suffer from relapsed disease after standard second-line chemotherapy face a dismal prognosis.	16424679
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Tailored strategy for AML patients receiving allogeneic peripheral blood stem cell transplantation.	16425195
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Considering the heterogeneity of acute myelogenous leukemia (AML), along with the pros and cons of allogeneic peripheral blood stem cell transplantation (PBSCT), a tailored strategy is needed to minimize the transplant-related mortality and maximize the transplant outcomes in AML patients exhibiting certain factors that have an impact on the post-transplant quality of life and outcomes.	16425195
Referral type - Psychiatric	Stem Cell Exhaustion	Stem cell transplantation: risk factors for psychiatric morbidity.	16426840
Mental disorders, Hematologic	Stem Cell Exhaustion	The aim of this study was to determine the risk factors for psychiatric disorder in haematological cancer patients during hospitalization for stem cell transplantation.	16426840
Referral type - Psychiatric	Stem Cell Exhaustion	Our study findings may help to improve identification of the patients most at risk for psychiatric disturbances during hospitalization for stem cell transplantation.	16426840
Pulmonary Alveolar Proteinosis, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Successful therapy with whole-lung lavage and autologous peripheral blood stem cell transplantation for pulmonary alveolar proteinosis complicating acute myelogenous leukemia.	16432866
Infection	Stem Cell Exhaustion	Subsequently, he received high-dose chemotherapy and autologous peripheral blood stem cell transplantation (PBSCT), which was performed safely without any infections.	16432866
Malignant Neoplasms	Stem Cell Exhaustion	Reduced intensity conditioning (RIC) for allogeneic stem cell transplantation allows stable donor cell engraftment with the maintenance of a graft versus malignancy effect.	16435017
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Incidence of Clostridium difficile-associated diarrhea before and after autologous peripheral blood stem cell transplantation for lymphoma and multiple myeloma.	16435018
Diarrhea	Stem Cell Exhaustion	Diarrhea is a major cause of morbidity and discomfort for patients undergoing high-dose chemotherapy and autologous peripheral blood stem cell transplantation (APBSCT).	16435018
neurological complication	Stem Cell Exhaustion	[Neurologic complications following hematopoietic stem cell transplantation.	16435442
neurological complication	Stem Cell Exhaustion	The frequency and cause of neurologic complications (NC) following hematopoietic stem cell transplantation (HSCT) have changed over time.	16435442
Malignant Fibrous Histiocytoma	Stem Cell Exhaustion	Tandem high-dose chemotherapy supported by autologous peripheral blood stem-cell transplantation and radiotherapy for recurrent malignant fibrous histiocytoma.	16437321
Secondary Neoplasm	Stem Cell Exhaustion	There was a high local recurrence and metastasis rate, and the patient was treated with radiotherapy and conventional chemotherapy followed by tandem high-dose chemotherapy and peripheral blood stem-cell transplantation.	16437321
Lymphoma, Follicular, Angioimmunoblastic Lymphadenopathy	Stem Cell Exhaustion	[Angioimmunoblastic T-cell lymphoma occurring four months after autologous peripheral blood stem cell transplantation with high-dose chemotherapy for follicular lymphoma].	16440766
Polycythemia Vera, Acute leukemia	Stem Cell Exhaustion	Polycythemia vera (PV) is a hematopoietic stem cell clonal disorder, 5 to approximately 10% of which will evolve into acute leukemia.	16440805
Polymyositis	Stem Cell Exhaustion	[Chronic GVHD with polymyositis after non-myeloablative stem cell transplantation].	16440806
Mantle cell lymphoma	Stem Cell Exhaustion	A 57-year-old man underwent an autologous hematopoietic stem cell transplant for mantle cell lymphoma in August 1999.	16440806
Malignant Neoplasms	Stem Cell Exhaustion	Comparison of peripheral blood progenitor cell yield from standard chemotherapy used in the treatment of lymphoid malignancies and high-dose cyclophosphamide: a retrospective review of 141 patients.	16441591
Multiple Myeloma	Stem Cell Exhaustion	A single dose of 6 or 12 mg of pegfilgrastim for peripheral blood progenitor cell mobilization results in similar yields of CD34+ progenitors in patients with multiple myeloma.	16441592
Multiple Myeloma	Stem Cell Exhaustion	Current regimens for peripheral blood progenitor cell (PBPC) mobilization in patients with multiple myeloma are based on daily subcutaneous injections of granulocyte-colony-stimulating factor (G-CSF) starting shortly after cytotoxic therapy.	16441592
Respiratory disturbances	Stem Cell Exhaustion	Transient respiratory disturbance by granulocyte-colony-stimulating factor administration in healthy donors of allogeneic peripheral blood progenitor cell transplantation.	16441593
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	In-vivo purging with the anti-CD20 antibody rituximab along with standard allogeneic peripheral blood stem cell transplantation (PBSCT) for relapsed childhood pre-B acute lymphoblastic leukaemia (ALL).	16441995
Graft-vs-Host Disease	Stem Cell Exhaustion	We evaluated tacrolimus/mycophenolate mofetil (MMF) for graft-versus-host disease (GVHD) prophylaxis after a nonmyeloablative stem cell transplantation (NST) from a matched sibling donor (MSD).	16443519
Hematologic Neoplasms	Stem Cell Exhaustion	Thirty-two patients (median age, 57 years) with advanced hematologic malignancies, who were poor candidates for a conventional myeloablative transplantation, received fludarabine (30 mg/m(2), day -4 to day -2), total-body irradiation (TBI) (200 cGy, day 0), infusion of donor peripheral blood progenitor cells (day 0), oral tacrolimus 0.06 mg/kg twice daily (from day 3), and oral MMF at 15 mg/kg twice daily (days 0-+27).	16443519
Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	A 4-month-old girl with clinical features of hemophagocytic lymphohistiocytosis (HLH) was successfully treated with immunochemotherapy but died at the age of 1 year and 3 months, before hematopoietic stem cell transplantation could be performed.	16443553
Hematological Disease, Neoplasms, Immune System Diseases	Stem Cell Exhaustion	The Accreditation Subcommittee of the EBMT regularly publishes special reports on current practice of haemopoietic stem cell transplantation for haematological diseases, solid tumours and immune disorders in Europe.	16444286
Toxic effect, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Stem cell transplantation may not be indicated for AML patient with DS in first remission, who display a high rate of life-threatening and fatal toxicity on therapy.	16444960
Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	[Successful treatment with oral ribavirin of adenovirus-associated hemophagocytic syndrome in a stem cell transplantation recipient].	16444970
Aplastic Anemia	Stem Cell Exhaustion	A 51-year-old woman with severe aplastic anemia underwent allogeneic peripheral blood stem cell transplantation using blood stem cells from an HLA-identical sibling.	16444970
Communicable Diseases	Stem Cell Exhaustion	Since therapeutic strategies for adenovirus infection after hematopoietic stem cell transplantation have not been established, we present our case and discuss the therapeutic approach.	16444970
Cervical Intraepithelial Neoplasia, Myelopoiesis	Stem Cell Exhaustion	These findings suggest that the impaired myelopoiesis in CIN patients is accompanied by a compensatory mechanism attempting to increase the neutrophil production at the myeloid progenitor cell level.	16445839
Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation, Aplastic Anemia, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	[Second transplant from the same donor without conditioning for bone marrow aplasia after non-myeloablative hematopoietic stem cell transplantation for chronic myeloid leukemia].	16447801
Cerebrovascular accident, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We describe a 56-year-old woman with chronic myeloid leukemia (CML) and a past history of stroke, who underwent nonmyeloablative hematopoietic stem cell transplantation (NST) with conditioning consisting of fludarabine and cyclophosphamide.	16447801
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	A second hematopoietic stem cell transplantation was performed without conditioning on day 157, and complete donor type hematopoiesis and molecular remission of CML were achieved.	16447801
Cardiovascular Diseases	Stem Cell Exhaustion	Age and cardiovascular disease status appear to alter numbers and function of circulating endothelial progenitor cells (EPCs).	16456866
Peripheral Arterial Diseases	Stem Cell Exhaustion	To further define the role of this lineage in peripheral artery disease (PAD), we developed a multiparameter flow cytometry assay to analyze multiple phenotypic definitions of progenitor cells (PCs), EPCs, and mature endothelial cells (ECs) and evaluate effects of age and PAD on baseline levels of each subset.	16456866
Hodgkin Disease	Stem Cell Exhaustion	We recently performed an autologous heterotopic ovarian transplantation in a 32-year-old Hodgkin lymphoma survivor who was menopausal for 2.5 years as a result of a preconditioning chemotherapy given before a hematopoietic stem cell transplant.	16459347
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A long-term follow-up analysis in adult acute myeloid leukemia patients after hematopoietic stem cell transplantation.	16459634
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Over the last 17 years, 119 adult acute myeloid leukemia patients have undergone hematopoietic stem cell transplantation at our Center.	16459634
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The outcome of autologous hematopoietic stem cell transplantation in patients not in first complete remission supports the possibility of achieving good quality second complete remissions and suggests that autografting may be a life-saving strategy in selected acute myeloid leukemia patients with advanced disease.	16459634
Allogeneic Hematopoietic Stem Cell Transplantation, Chronic graft-versus-host disease	Stem Cell Exhaustion	Sclerodermatous chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation: incidence, predictors and outcome.	16461315
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Stem Cell Exhaustion	Management consisted of supportive therapy, followed by chemotherapy for T-cell acute lymphoblastic leukemia and stem cell transplantation.	16462583
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Outcome of reduced-intensity allogeneic hematopoietic stem cell transplantation (RISCT) using antilymphocyte antibodies in patients with high-risk acute myeloid leukemia (AML).	16462757
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We report 17 consecutive patients with high-risk AML whose median age was 58 years and who received stem cells from HLA-matched siblings (n=5), or alternative donors (n=12).	16462757
Mycoses	Stem Cell Exhaustion	Furthermore, in comparing the rate of mycoses in recipients of stem cell transplantation with that of non-recipients, that of recipients was about 10% higher.	16465136
Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Upfront double high-dose chemotherapy with DICEP followed by BEAM and autologous stem cell transplantation for poor-prognosis aggressive non-Hodgkin lymphoma.	16467197
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Protection of adult mouse progenitor cells and human glioma cells by de novo decorin expression in an oxygen- and glucose-deprived cell culture model system.	16467781
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Therefore, our data suggest that decorin is a potent trophic factor that protects neuronal progenitor cells and glioma cells from OGD.	16467781
Hair follicle structure, Neoplasms	Stem Cell Exhaustion	To clarify the features of apocrine mixed tumors (AMT) of the skin among benign neoplasms with apocrine differentiation in their relationship to follicular stem cells, we investigated the immunohistochemical expression of CK15 (LHK15 and C8/144B), which is a relatively specific marker of hair follicle stem cells in the bulge, in 35 cases of eight different benign neoplasms with presumed apocrine differentiation.	16469077
Neoplasms	Stem Cell Exhaustion	AMT of the skin are unique among benign neoplasms with apocrine differentiation in their substantial and constant CK15 expression, suggesting that they derive from multipotent epithelial stem cells in the bulge.	16469077
Neoplasms	Stem Cell Exhaustion	The partially positive reaction for CK15 in syringocystadenomas papilliferum and spiradenoma/cylindroma may depend on the ability to express CK15 in stem cells with an apocrine fate or result from the follicular and apocrine nature of this neoplasm.	16469077
Burn injury, Herpes	Stem Cell Exhaustion	The appearance of limbal stem cell deficiency is chiefly concentrated on pemphigoids, Herpes relapses and alkali burns and represents the main part of high-risk keratoplasty.	16470381
PAFAH1B1 wt Allele	Stem Cell Exhaustion	The aim of this study was to evaluate phenotypic changes on HPC in MDS that could reflect abnormalities in the differentiation process of stem cells.	16470534
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Increased immature hematopoietic progenitor cells CD34+/CD38dim in myelodysplasia.	16470534
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are clonal disorders affecting hematopoietic progenitor cells (HPC).	16470534
Carcinogenesis	Stem Cell Exhaustion	A stem cell fusion model of carcinogenesis.	16471036
Specialty Type - cancer	Stem Cell Exhaustion	Specifically, cancer can result from a fusion between an "altered" pre-malignant cell and a bone marrow-derived stem cell (BMDSC).	16471036
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myeloid leukemia (CML) originates from the hematopoietic stem cell and is characterized by the reciprocal translocation t(9;22)(q34;q11), which results in the BCR-ABL fusion gene on chromosome 22q-, also known as the Philadelphia chromosome.	16475128
Graft-vs-Host Disease, primary disorders	Stem Cell Exhaustion	There were no differences in primary disease, risk, HLA disparity, GVHD prophylaxis and stem cell source.	16479977
Muscular Dystrophy, Duchenne	Stem Cell Exhaustion	Human skeletal muscle stem cells from healthy donors aged 2-82 years (n = 13) and from three children suffering from Duchenne Muscular Dystrophy (DMD) were implanted into soleus muscles of immunoincompetent mice and were also expanded in vitro until senescence.	16480387
Disease	Stem Cell Exhaustion	This approach, if confirmed on larger series and other diseases, could open new opportunities in stem cell mobilization for poor or non-mobilizers.	16480428
Neoplasms	Stem Cell Exhaustion	Treatment in survivors included surgery in 51 (75% [39/51] complete tumor resection [CTR]); chemotherapy, 50; radiation, 17; stem cell transplantation, 20; and bone marrow transplant, 1.	16481255
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Reduced intensity conditioning allows for up-front allogeneic hematopoietic stem cell transplantation after cytoreductive induction therapy in newly-diagnosed high-risk acute myeloid leukemia.	16482208
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The clinical trial reported here investigated a new approach of up-front allogeneic hematopoietic stem cell transplantation (HSCT), provided a median of 40 days (range 22-74) after diagnosis, in twenty-six consecutive patients with newly-diagnosed high-risk AML characterized by poor-risk cytogenetics (n = 19) or inadequate blast clearance by induction chemotherapy (IC, n = 7).	16482208
Agenesis	Stem Cell Exhaustion	During IC-induced aplasia after the 1st (n = 11) or 2nd (n = 15) cycle, patients received allogeneic peripheral blood stem cells (PBSC) from related (n = 11) or unrelated (n = 15) donors following a fludarabine-based reduced-intensity regimen.	16482208
Encephalitis, St. Louis	Stem Cell Exhaustion	Autologous haematopoietic stem cell transplantation has become an accepted powerful therapeutic procedure for patients with severe, intractable SLE.	16482745
Nephrotic Syndrome, Lupus Nephritis	Stem Cell Exhaustion	Here we describe a 26-year old patient with stage IV-G diffuse global proliferative lupus nephritis and refractory nephrotic syndrome who responded to autologous peripheral stem cell transplantation (ASCT) after two mobilization procedures.	16482745
Hematopoietic stem cells	Stem Cell Exhaustion	Aberrant alternative splicing of interferon regulatory factor-1 (IRF-1) in myelodysplastic hematopoietic progenitor cells.	16483648
Abdominal Pain, Varicella Zoster Virus Infection	Stem Cell Exhaustion	Visceral varicella zoster virus infection after stem cell transplantation: a possible cause of severe abdominal pain.	16484131
varicella zoster, herpesvirus 3, human	Stem Cell Exhaustion	Reactivation of varicella zoster virus (VZV) is a common event after stem cell transplantation (SCT).	16484131
Hepatitis, Multiple Myeloma, Cordonnier Grade 2 Viral Complication, Varicella Zoster Virus Infection, Melena	Stem Cell Exhaustion	We describe the case of a 53-year-old man who had undergone stem cell autograft for multiple myeloma and developed visceral VZV infection with hepatitis, melaena and subileus 7 months later.	16484131
Neoplasms	Stem Cell Exhaustion	Nestin may be a useful immunohistochemical marker for identifying these tumours; the presence of this persistent stem cell cytoskeletal filament within GI GCTs suggests that these lesions may arise from a multipotential stem cell in the GI tract.	16487364
Neurilemmoma, Gastrointestinal Stromal Tumors	Stem Cell Exhaustion	Nestin is a recently identified intermediate filament protein that is expressed in neuroectodermal stem cells and skeletal muscle progenitor cells and has been shown to be expressed in gastrointestinal stromal tumours (GISTs) and GI schwannomas.	16487364
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Although the concept that cancers arise from "stem cells" or "germ cells" was first proposed about 150 years ago, it is only recently that advances in stem cell biology have given new impetus to the "cancer stem cell hypothesis."	16488983
Neoplasms	Stem Cell Exhaustion	As a result of this, (b) tumors contain a cellular subcomponent that retains key stem cell properties.	16488983
Neoplasms, Specialty Type - cancer, Carcinogenesis	Stem Cell Exhaustion	Recent experimental evidence in a variety of tumors has lent strong support to the cancer stem cell hypothesis that represents a paradigm shift in our understanding of carcinogenesis and tumor cell biology.	16488983
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Furthermore, the current development of cancer therapeutics based on tumor regression may have produced agents that kill differentiated tumor cells while sparing the rare cancer stem cell population.	16488983
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells: an old idea--a paradigm shift.	16488983
Neoplasms	Stem Cell Exhaustion	Two important related concepts of this hypothesis are that (a) tumors originate in either tissue stem cells or their immediate progeny through dysregulation of the normally tightly regulated process of self-renewal.	16488983
Toxic effect, Amyloidosis	Stem Cell Exhaustion	Autologous stem-cell transplantation in progressing amyloidosis is associated with severe transplant-related toxicity.	16489526
Cessation of life, Amyloidosis, Single organ dysfunction	Stem Cell Exhaustion	Amyloid light-chain (AL) amyloidosis is a disorder of plasma cells in which depositions of immunoglobulin light-chain fragments cause progressive organ failure and death with a median survival of one year, but autologous stem-cell transplantation can induce high response rates, especially in isolated renal involvement.	16489526
Sepsis	Stem Cell Exhaustion	One patient died as a result of sepsis after stem-cell mobilization.	16489526
Amyloidosis	Stem Cell Exhaustion	Treatment of selected patients with AL-amyloidosis by high-dose melphalan and stem-cell support results in reversal of amyloid-related disease in a substantial proportion of patients and improved survival.	16489526
Chronic heart failure	Stem Cell Exhaustion	Safety and effectiveness of granulocyte-colony stimulating factor in mobilizing stem cells and improving cytokine profile in advanced chronic heart failure.	16490437
Heart failure	Stem Cell Exhaustion	The objective of this study was to determine a safe and effective dose of granulocyte-colony stimulating factor (G-CSF) to mobilize hematopoietic stem cells in patients with advanced heart failure and to determine its effects on the cytokine profile.	16490437
Heart failure	Stem Cell Exhaustion	Our results have shown that low-dose G-CSF significantly mobilized hematopoietic stem cells in advanced heart failure and improved left ventricular function in the ischemic subset of patients.	16490437
Cerebrovascular accident	Stem Cell Exhaustion	The use of stem cells in animal models has led to functional improvement following stroke.	16491209
Liver carcinoma	Stem Cell Exhaustion	Treatment with stem cell differentiation stage factors of intermediate-advanced hepatocellular carcinoma: an open randomized clinical trial.	16491958
Neoplasms	Stem Cell Exhaustion	We developed a product containing stem cells differentiation stage factors (SCDSF) that inhibits tumor growth in vivo and in vitro.	16491958
Aplastic Anemia	Stem Cell Exhaustion	Reduced-intensity stem cell transplantation represents an affordable alternative to traditional more cytotoxic conditioning for severe aplastic anemia (SAA) patients.	16493614
Aplastic Anemia	Stem Cell Exhaustion	Allografting in patients with severe, refractory aplastic anemia using peripheral blood stem cells and a fludarabine-based conditioning regimen: the Mexican experience.	16493614
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	hTERT, the catalytic component of telomerase, is downregulated in the haematopoietic stem cells of patients with chronic myeloid leukaemia.	16498395
Leukemic Blast Count, Stem Cell Factor, Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome	Stem Cell Exhaustion	A modified whole blood fixation protocol was developed for the AML/MDS trial, using the c-kit ligand stem cell factor (SCF) to activate ERK as an alternative to PMA, and incorporating immunophenotypic markers to identify leukemic blasts.	16498671
Stem Cell Factor	Stem Cell Exhaustion	Furthermore, normal donor CD34+ve stem cells were much more sensitive to BAY 43-9006 when ERK was activated by SCF, compared to PMA.	16498671
Malignant neoplasm of ovary	Stem Cell Exhaustion	Phase I study of high-dose topotecan with haematopoietic stem cell support in the treatment of ovarian carcinomas: the ITOV 01 protocol.	16501591
Neoplasms	Stem Cell Exhaustion	In order to increase the tumour response rate and to define the maximum tolerated dose (MTD) of topotecan, we decided to develop a high-dose phase I regimen supported by stem cell support.	16501591
Multiple Myeloma	Stem Cell Exhaustion	Predictive factors for survival in myeloma patients who undergo autologous stem cell transplantation: a single-centre experience in 211 patients.	16501593
Multiple Myeloma	Stem Cell Exhaustion	High-dose therapy with autologous stem cell therapy (ASCT) has become the treatment of choice for eligible patients with myeloma.	16501593
Gastrointestinal mucositis	Stem Cell Exhaustion	Study on the normal saline vs povidone-iodine mouthwashes for oral mucositis (OM) prophylaxis in patients after high-dose chemotherapy comprising bischloroethyl nitrosourea etoposide ara-C melphalan (BEAM) or high-dose melphalan (HD-L-PAM) followed by autologous peripheral stem cell transplantation indicated that females have higher a incidence of OM compared to men, as reported by [Vokurka et al.	16502004
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	[Second nonmyeloablative allogeneic peripheral blood stem cell transplantation with more immunosuppressive conditioning regimen for the late graft failure of the patient with acute myeloid leukemia].	16502857
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 53-year-old woman with acute myeloid leukemia (M2; normal karyotype) in first remission underwent the nonmyeloablative allogeneic peripheral blood stem cell transplantation from her HLA-identical brother, with conditioning consisting of fludarabine and low dose total body irradiation (2Gy).	16502857
Toxic effect	Stem Cell Exhaustion	Four patients (5%) did not undergo autologous hematopoietic progenitor cell transplantation because of toxicity from high-dose cyclophosphamide and etoposide.	16503501
Childhood Non-Hodgkin Lymphoma, Multiple Myeloma, Waldenstrom Macroglobulinemia	Stem Cell Exhaustion	We evaluated the efficiency of high doses of cyclophosphamide (6 g/m2) and etoposide (2 g/m2) plus filgrastim (granulocyte colony-stimulating factor; G-CSF) to mobilize autologous hematopoietic progenitor cells in patients with non-Hodgkin lymphoma, multiple myeloma, and Waldenstrom macroglobulinemia.	16503501
Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	We conclude that high doses of cyclophosphamide and etoposide combined with G-CSF are an efficient and safe mobilizing regimen for the collection of hematopoietic progenitor cells during aggressive cytoreduction of tumor burden in patients with lymphoid malignancies.	16503501
Acute GVH disease	Stem Cell Exhaustion	Longitudinal analysis of T-cell receptor variable beta chain repertoire in patients with acute graft-versus-host disease after allogeneic stem cell transplantation.	16503503
Graft-vs-Host Disease	Stem Cell Exhaustion	T-cell receptor variable beta chain (TCRBV) repertoire spectratyping involves the estimation of CDR3 length distributions for monitoring T-cell receptor diversity and has proven useful for analyses of immune reconstitution and T-cell clonal expansions in graft-versus-host disease (GVHD) and graft-versus-leukemia after allogeneic stem cell transplantation.	16503503
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Inflammatory cytokines predominate in cases of tumor regression after hematopoietic stem cell transplantation for solid cancer.	16503504
Primary Malignant Liver Neoplasm	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (SCT) has recently been presented as promising immunotherapy against renal cell, colon, ovarian, breast, and primary liver cancer.	16503504
Hodgkin Disease, herpesvirus 3, human, Granuloma Annulare	Stem Cell Exhaustion	Granuloma annulare on herpes zoster scars in a Hodgkin's disease patient following autologous peripheral stem cell transplantation.	16503895
Hodgkin Disease, herpesvirus 3, human, Granuloma Annulare	Stem Cell Exhaustion	A 46-year-old man with Hodgkin's disease developed localized granuloma annulare lesions on herpes zoster scars 3 months after allogeneic peripheral stem cell transplantation.	16503895
Granuloma Annulare, herpesvirus 3, human	Stem Cell Exhaustion	This is the first case of granuloma annulare localized on herpes zoster scars that developed following peripheral stem cell transplantation.	16503895
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	There has been marginal success in treating PTLD using a number of treatment modalities, including combination chemotherapy with anti-CD20 or high-dose chemotherapy with stem cell rescue.	16504695
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Lung-located PTLD has been reported in recipients of the heart, cord blood stem cells, lungs, and bone marrow transplants, but only four cases were reported previously after kidney transplantation.	16504695
diabetic	Stem Cell Exhaustion	Endothelial progenitor cells and the diabetic paradox.	16505536
Neutropenia, Hematologic Neoplasms	Stem Cell Exhaustion	In 50 of these patients (60%), no high risk predisposing conditions (neutropenia, hematologic cancer and stem cell or bone marrow transplantation) were found.	16507158
Acute myocardial infarction	Stem Cell Exhaustion	Stem cell mobilization by granulocyte colony-stimulating factor in patients with acute myocardial infarction: a randomized controlled trial.	16507801
Acute myocardial infarction	Stem Cell Exhaustion	To assess the value of stem cell mobilization by G-CSF therapy in patients with acute myocardial infarction.	16507801
Infarction, Acute myocardial infarction, Coronary Restenosis	Stem Cell Exhaustion	Stem cell mobilization by G-CSF therapy in patients with acute myocardial infarction and successful mechanical reperfusion has no influence on infarct size, left ventricular function, or coronary restenosis.	16507801
Acute myocardial infarction	Stem Cell Exhaustion	Experimental studies and early phase clinical trials suggest that transplantation of blood-derived or bone marrow-derived stem cells may improve cardiac regeneration and neovascularization after acute myocardial infarction.	16507801
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Circulating haemopoietic and endothelial progenitor cells are decreased in COPD.	16507853
Peripheral Blood Stem Cells, Tumor cells, malignant	Stem Cell Exhaustion	High-dose chemotherapy (HDCT) with peripheral blood stem cell (PBSC) support has been investigated as a first-line treatment in patients with poor risk germ cell cancer.	16508731
Myxoma of the Endocardium	Stem Cell Exhaustion	Cardiac myxoma cells exhibit embryonic endocardial stem cell features.	16508920
Cerebral Infarction	Stem Cell Exhaustion	Correlation between copper/zinc superoxide dismutase and the proliferation of neural stem cells in aging and following focal cerebral ischemia.	16509156
Carcinosarcoma, Dermoid Cyst	Stem Cell Exhaustion	To the best of our knowledge, this is the first case of carcinosarcoma arising from a dermoid cyst in which a histogenetic origin from totipotent stem cells, located in the basal squamous layer, is supported by immunohistochemical findings.	16509974
Cessation of life, Aspergillosis	Stem Cell Exhaustion	Prognostic factors for death due to invasive aspergillosis after hematopoietic stem cell transplantation: a 1-year retrospective study of consecutive patients at French transplantation centers.	16511759
Cessation of life, Aspergillosis	Stem Cell Exhaustion	Invasive aspergillosis (IA) is a major cause of death after hematopoietic stem cell transplantation (HSCT).	16511759
Coronary Arteriosclerosis, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Successful reduced-intensity hematopoietic stem cell transplantation in myelodysplastic syndrome with severe coronary artery disease.	16513535
PAFAH1B1 wt Allele	Stem Cell Exhaustion	The clinical course of the patient suggests that this preparative regimen allows safe allogeneic stem cell transplantation for MDS patients with severe CAD.	16513535
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	The respective frequencies of acute graft-versus-host disease (GVHD) and chronic GVHD were 41.1% and 34.9% for related bone marrow transplantation (BMT), 66.8% and 34.5% for unrelated BMT, 52.9% and 36.0% for allogeneic peripheral blood stem cell transplantation, and 53.3% and 32.1% for allogeneic cord blood transplantation.	16513537
Purpura, Thrombotic Thrombocytopenic	Stem Cell Exhaustion	Plasma exchange for thrombotic thrombocytopenic purpura following hematopoietic stem cell transplantation.	16515239
Graft-vs-Host Disease, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 17 years old female diagnosed with acute myeloid leukemia (AML)-M2 received an allogeneic haematopoietic stem cell transplant (HSCT) and was given graft versus host disease (GVHD) prophylaxis with methotrexate, cyclosporin-A (CsA) and methyl prednisolone.	16515239
Depression, CTCAE, Diabetes, glycation	Stem Cell Exhaustion	Depression of progenitor cell function by advanced glycation endproducts (AGEs): potential relevance for impaired angiogenesis in advanced age and diabetes.	16515851
Diabetes, Adaptation, Ocular	Stem Cell Exhaustion	This AGEs-mediated impairment of progenitor cell function identifies a new pathophysiological mechanism of disturbed vascular adaptation in diabetes or ageing and suggests that lowering AGEs in recipients of progenitor cell therapy might be beneficial for the success of this therapy.	16515851
physiopathological, Diabetes	Stem Cell Exhaustion	Diabetes and ageing induce reduction and dysfunction of vascular progenitor cells.	16515851
Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	Postoperative chemotherapy was followed by high-dose chemotherapy and rescue with peripheral blood stem cell transplantation, and he has now been well for 6 years.	16516645
Pancreatoblastoma	Stem Cell Exhaustion	This is the first surviving pediatric case of advanced pancreatoblastoma treated by aggressive surgical therapy including reconstruction of the portal vein and high-dose chemotherapy followed by peripheral blood stem cell transplantation.	16516645
Neoplasms	Stem Cell Exhaustion	In the present study, new findings include the immunohistochemical identification of vascular endothelial growth factor (VEGF) and the lack of PDX-1 (putative master transcriptional factor in pancreatic stem cells) in the epithelial tumor cells.	16517478
Ischemic stroke	Stem Cell Exhaustion	Because granulocyte colony-stimulating factor (G-CSF) has anti-inflammatory and neuroprotective properties and is known to mobilize stem cells, it may be useful in the treatment of acute ischemic stroke.	16517764
Gastrointestinal mucositis	Stem Cell Exhaustion	A prospective, double-blind phase II study evaluating the safety and efficacy of a topical histamine gel for the prophylaxis of oral mucositis in patients post hematopoietic stem cell transplantation.	16518424
Gastrointestinal mucositis	Stem Cell Exhaustion	The aim of this study was to evaluate the safety, tolerability and efficacy of a topical gel containing histamine dihydrochloride (HDC) versus a placebo gel in preventing oral mucositis in hematopoietic stem cell transplantation (HSCT) patients.	16518424
Graft-vs-Host Disease	Stem Cell Exhaustion	Donor methylenetetrahydrofolate reductase genotype is associated with graft-versus-host disease in hematopoietic stem cell transplant patients treated with methotrexate.	16518429
Graft-vs-Host Disease	Stem Cell Exhaustion	Methotrexate (MTX), used as a graft-versus-host disease (GvHD) prophylactic agent in hematopoietic stem cell transplantation (HSCT), exerts its effect via folate cycle inhibition.	16518429
Metapneumovirus	Stem Cell Exhaustion	Brief communication: fatal human metapneumovirus infection in stem-cell transplant recipients.	16520475
Respiratory Tract Diseases	Stem Cell Exhaustion	Hematopoietic stem-cell transplant recipients who underwent BAL because of lower respiratory tract disease.	16520475
Colorectal Carcinoma, Adenoma of large intestine	Stem Cell Exhaustion	We compared the serum levels of stem cell factor (SCF), interleukin 3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), and macrophage colony-stimulating factor (M-CSF) in 97 colorectal cancer patients with those in 35 patients with colorectal adenomas and 65 healthy subjects (control group).	16520929
Specialty Type - cancer	Stem Cell Exhaustion	Hematopoietic cytokines (HCs) regulate the proliferation and differentiation of hematopoietic progenitor cells, and it was proved that HCs can promote cancer growth.	16520929
Narrow pelvis bone	Stem Cell Exhaustion	This study is a prospective analysis of 10 patients who underwent intradiscal injection of hematopoietic precursor stem cells (HSCs) obtained from their pelvic bone marrow in an attempt to rejuvenate the disc.	16522171
Anaplastic Oligodendroglioma	Stem Cell Exhaustion	High-dose chemotherapy with stem cell rescue as initial therapy for anaplastic oligodendroglioma: long-term follow-up.	16524945
Anaplastic Oligodendroglioma	Stem Cell Exhaustion	We previously reported a phase 2 trial of 69 patients with newly diagnosed anaplastic or aggressive oligodendroglioma who were treated with intensive procarbazine, CCNU (lomustine), and vincristine (PCV) followed by high-dose thiotepa with autologous stem cell rescue.	16524945
Multiple Myeloma	Stem Cell Exhaustion	Between October 1998 and February 2004, 668 patients with newly diagnosed multiple myeloma received two cycles of intensive melphalan-based chemotherapy, each supported by autologous hematopoietic stem-cell transplantation.	16525139
Lymphoma, Non-Hodgkin, Multiple Myeloma	Stem Cell Exhaustion	Between June 2003 and November 2004, we collected mobilized peripheral blood units from 29 patients with non-Hodgkin's lymphoma and multiple myeloma for autologous peripheral blood stem cell transplantation.	16525786
Evans syndrome	Stem Cell Exhaustion	Successful unrelated cord blood transplantation in a 7-year-old boy with Evans syndrome refractory to immunosuppression and double autologous stem cell transplantation.	16529601
Evans syndrome	Stem Cell Exhaustion	A 2-yr-old boy with Evans syndrome showed only short-lasting responses to immunosuppressive treatment including double autologous peripheral stem cell transplantation (SCT).	16529601
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	Our study indicates that PIG-A mutations of hematopoietic stem cells with resultant PNH clones, are relatively common among AA patients.	16529603
Specialty Type - cancer	Stem Cell Exhaustion	A different situation can be seen in immortal cells, such as cancer, germ and stem cells, where telomeres are maintained by telomerase, a specialized reverse transcriptase that is involved in synthesis of telomeres.	16530337
Secondary Acute Myeloid Leukemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Long-term follow-up of autologous stem cell transplantation after intensive chemotherapy in patients with myelodysplastic syndrome or secondary acute myeloid leukemia.	16531261
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Stem cell mobilization induced by subcutaneous granulocyte-colony stimulating factor to improve cardiac regeneration after acute ST-elevation myocardial infarction: result of the double-blind, randomized, placebo-controlled stem cells in myocardial infarction (STEMMI) trial.	16531621
Acute myocardial infarction	Stem Cell Exhaustion	Bone marrow stem cell mobilization with subcutaneous G-CSF is safe but did not lead to further improvement in ventricular function after acute myocardial infarction compared with the recovery observed in the placebo group.	16531621
Liver carcinoma	Stem Cell Exhaustion	A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells.	16532004
Hollings Cancer Center	Stem Cell Exhaustion	The gene expression program that distinguished this subtype from other types of HCC included markers of hepatic oval cells, suggesting that HCC of this subtype may arise from hepatic progenitor cells.	16532004
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Apheresis instrument settings influence infused absolute lymphocyte count affecting survival following autologous peripheral hematopoietic stem cell transplantation in non-Hodgkin's lymphoma: the need to optimize instrument setting and define a lymphocyte collection target.	16532018
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Autograft absolute lymphocyte count (A-ALC) is an independent prognostic factor for survival after autologous peripheral blood hematopoietic stem cell transplantation (APHSCT) for non-Hodgkin's lymphoma (NHL).	16532018
HLA Mismatch	Stem Cell Exhaustion	HLA-C mismatch is associated with inferior survival after unrelated donor non-myeloablative hematopoietic stem cell transplantation.	16532020
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome, Acute leukemia	Stem Cell Exhaustion	The progenitor cells of myelodysplastic syndrome (MDS) are thought to undergo a multistep process during their transformation into overt acute leukemia.	16533529
Huntingtons Disease Pathway	Stem Cell Exhaustion	One of the criticisms of a potential endogenous progenitor cell replacement therapy has been that the endogenous progenitor cells also contain the Huntington's disease gene and would therefore be just as susceptible to degeneration as those in the degenerate brain region.	16533591
Huntingtons Disease Pathway	Stem Cell Exhaustion	A novel population of progenitor cells expressing cannabinoid receptors in the subependymal layer of the adult normal and Huntington's disease human brain.	16533591
Neurodegenerative Disorders, Parkinson Disease, "Alzheimers Disease", "Huntingtons Disease Pathway	Stem Cell Exhaustion	Progenitor cells in the adult human brain subependymal layer are capable of producing new neurons and glial cells that may be useful as a source of cells for endogenous cell replacement for regions of the brain that undergo degeneration due to a neurodegenerative disease such as Huntington's disease, Parkinson's disease or Alzheimer's disease.	16533591
Huntingtons Disease Pathway	Stem Cell Exhaustion	We have previously demonstrated that in the human Huntington's disease brain there are increased numbers of progenitor cells proportional to the severity of the gene defect responsible for the disease and proportional to the severity of the pathology of the disease.	16533591
Gaucher Disease, Type 1	Stem Cell Exhaustion	We investigated peripheral blood dendritic cell-precursors, as well as the potential of peripheral blood monocytes and bone marrow-derived progenitor cells, to differentiate into mature dendritic cells in 12 patients with type I Gaucher disease.	16533613
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation for chronic myeloid leukemia in Europe 2006: transplant activity, long-term data and current results.	16533723
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The introduction of imatinib mesylate has changed attitudes towards hematopoietic stem cell transplantation (HSCT) for chronic myeloid leukemia (CML).	16533723
Multiple Myeloma	Stem Cell Exhaustion	Vinorelbine plus intermediate dose cyclophosphamide is an effective and safe regimen for the mobilization of peripheral blood stem cells in patients with multiple myeloma.	16538502
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	High dose cyclophosphamide (HD-Cy) is commonly used to mobilize stem cells in multiple myeloma (MM).	16538502
Erectile dysfunction	Stem Cell Exhaustion	Circulating endothelial progenitor cells and endothelial function after chronic Tadalafil treatment in subjects with erectile dysfunction.	16541115
Erectile dysfunction	Stem Cell Exhaustion	We evaluated the effect of a chronic treatment with Tadalafil on progenitor cells (PCs) number and endothelial function in patients with erectile dysfunction (ED) with or without cardiovascular risk factors.	16541115
Chronic graft-versus-host disease	Stem Cell Exhaustion	Spermatogenesis in long-term survivors after allogeneic hematopoietic stem cell transplantation is associated with age, time interval since transplantation, and apparently absence of chronic GvHD.	16543466
Corneal Ulcer, Keratopathy, Rheumatoid Factor, Autoimmune Lymphoproliferative Syndrome Type 2B	Stem Cell Exhaustion	Five patients aged 36-88 years, were suffering from six PEDs for 73.5+/-46.9 days due to rheumatoid sterile corneal ulcer (n=1), neurotrophic keratopathy (n=3) or partial limbal stem cell deficiency (n=1).	16544115
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The optimal postremission treatment for elderly patients with acute myelogenous leukemia (AML) is presently unknown, but recent studies report the feasibility of autologous stem cell transplantation in this population.	16545730
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Long-term outcome of autologous transplantation of peripheral blood progenitor cells as postremission management of patients > or =60 years with acute myelogenous leukemia.	16545730
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	To better understand the long-term outcome of autologous transplantation in AML patients > or =60 years of age, we evaluated high-dose chemoradiotherapy preparative conditioning followed by transplantation of peripheral blood progenitor cells procured after a single cycle of cytarabine-based consolidation chemotherapy as postremission therapy in 27 patients aged 60 to 71 years (median age, 65 years) with newly diagnosed AML in first complete remission (CR).	16545730
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Our results demonstrate that autologous transplantation of peripheral blood progenitor cells is well tolerated and feasible for patients > or =60 years of age with AML in first CR.	16545730
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Among 1040 transplantations, including 931 renal, 14 heart, 55 liver and 40 allogeneic peripheral blood stem cell (PBSC), 8 patients (7 male, 1 female) were diagnosed with PTLD.	16549195
Intestinal metaplasia	Stem Cell Exhaustion	However, in one case, NSE and Barrett's epithelium seem to have arisen from a progenitor cell that was capable of differentiating into either intestinal metaplasia or NSE.	16551852
T cell mediated cytotoxicity, Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	Due to impaired natural killer (NK) and T-cell cytotoxicity implying a high risk of developing hemophagocytic lymphohistiocytosis (HLH), he was prepared for hematopoietic stem cell transplantation (HSCT).	16551969
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Long-term survival in refractory acute myeloid leukemia after sequential treatment with chemotherapy and reduced-intensity conditioning for allogeneic stem cell transplantation.	16551971
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A sequential regimen of chemotherapy, reduced-intensity conditioning (RIC) for allogeneic stem cell transplantation (SCT), and prophylactic donor lymphocyte transfusion (pDLT) was studied in 103 patients with refractory acute myeloid leukemia (AML).	16551971
Pneumocystis carinii, Trichosporon beigelii	Stem Cell Exhaustion	Pneumocystis carinii and Trichosporon beigelii pneumonia following allogeneic haemopoeitic stem cell transplantation.	16555641
Acute lymphocytic leukemia	Stem Cell Exhaustion	We report a case of a young lady who underwent haemopoeitic stem cell transplantation for relapsed acute lymphoblastic leukemia.	16555641
Graft-vs-Host Disease	Stem Cell Exhaustion	A case of sclerodermatous graft-versus-host disease following autologous peripheral blood stem cell transplantation.	16556284
Graft-vs-Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	We report a 65-year-old woman with chronic graft-versus-host disease (GVHD) who developed severely sclerotic skin on the fingers, hand and trunk following autologous peripheral blood stem cell transplantation (APBSCT).	16556284
Angina, Unstable	Stem Cell Exhaustion	[Change in endothelial progenitor cells and endothelial function in patients with unstable angina pectoris].	16563250
Lesion	Stem Cell Exhaustion	Marked recovery of severe renal lesions in POEMS syndrome with high-dose melphalan therapy supported by autologous blood stem cell transplantation.	16564945
methyldopa	Stem Cell Exhaustion	Surgically excised CNV (n = 9) membranes from patients with AMD were probed with immunohistochemical techniques using the following monoclonal antibodies: AC133 a putative marker of EPCs and hematopoietic stem cells (HSCs); the endothelial cells markers CD31, CD34, and von Willebrand factor (vWF); and cytokeratins and CD68, markers for retinal pigment epithelium (RPE) and macrophages, respectively.	16565404
Choroidal Neovascularization	Stem Cell Exhaustion	The presence of AC133-positive cells suggests a possible role of endothelial progenitor cells in the formation of choroidal neovascularization.	16565404
Choroidal Neovascularization, methyldopa	Stem Cell Exhaustion	The purpose of the present study was to determine whether markers of endothelial progenitor cells (EPCs) are present in choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD).	16565404
Lymphoproliferative Disorders	Stem Cell Exhaustion	Reduced-intensity allogeneic haemopoietic stem cell transplantation induces durable responses in patients with chronic B-lymphoproliferative disorders.	16565735
Multiple Myeloma	Stem Cell Exhaustion	Maintenance thalidomide following single cycle autologous peripheral blood stem cell transplant in patients with multiple myeloma.	16565743
Multiple Myeloma	Stem Cell Exhaustion	Although autologous stem cell transplant is an effective therapy for patients with multiple myeloma and extends progression-free survival (PFS) and overall survival (OS), patients show a continued pattern of recurrent disease.	16565743
Multiple Myeloma	Stem Cell Exhaustion	Complete response in multiple myeloma: clinical trial E9486, an Eastern Cooperative Oncology Group study not involving stem cell transplantation.	16565956
leukemia	Stem Cell Exhaustion	Availability of these cells should allow clinical trials for salvage treatment of leukemia patients relapsing after allogeneic stem cell transplantation.	16569594
Prostate carcinoma	Stem Cell Exhaustion	A phase 2 study of high-activity 186Re-HEDP with autologous peripheral blood stem cell transplant in progressive hormone-refractory prostate cancer metastatic to bone.	16572306
Prostate carcinoma, Hormone refractory prostate cancer	Stem Cell Exhaustion	We investigated the potential for improvement in disease control by use of autologous peripheral blood stem cell transplant (PBSCT) to permit administration of high activities of (186)Re-hydroxyethylidene diphosphonate (HEDP) in patients with progressive hormone-refractory prostate cancer (HRPC).	16572306
Metastatic Malignant Neoplasm to the Leptomeninges, Disseminated neuroblastoma	Stem Cell Exhaustion	A 3-year-old male, diagnosed with stage 4 neuroblastoma, developed recurrent leptomeningeal metastasis after multi-modality treatment including multi-agent chemotherapy, surgery, high dose chemotherapy plus stem cell rescue, cis-retinoic acid and intravenous (IV) topotecan.	16572404
Venoocclusive disease, Multiple Myeloma	Stem Cell Exhaustion	Absence of veno-occlussive disease in a cohort of multiple myeloma patients undergoing autologous stem cell transplantation with targeted busulfan dosage.	16573745
Toxic effect, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Plasma concentrations of oral busulfan (BU) were measured in multiple myeloma (MM) patients undergoing autologous peripheral blood stem cell transplantation (ASCT) with a double alkylating conditioning protocol in order to individualise doses of BU based on individual pharmacokinetic parameters and to reduce toxicities related to BU exposure.	16573745
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Phase I and pharmacokinetic study of once-daily dosing of intravenously administered busulfan in the setting of a reduced-intensity preparative regimen and allogeneic hematopoietic stem cell transplantation as immunotherapy for renal cell carcinoma.	16578989
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	We performed a Phase I and pharmacokinetic study of once-daily, intravenously administered busulfan in the setting of a reduced-intensity preparative regimen and matched sibling donor allogeneic stem cell transplantation for treatment of metastatic renal cell carcinoma.	16578989
Multiple Myeloma	Stem Cell Exhaustion	A 60-year-old woman with multiple myeloma relapsed after a good partial response to high-dose chemotherapy (melphalan 200 mg/m(2)) and autologous stem-cell transplantation, followed by thalidomide and prednisolone maintenance therapy.	16596146
Acute GVH disease	Stem Cell Exhaustion	Serum cytokine concentrations and acute graft-versus-host disease after allogeneic peripheral blood stem cell transplantation: concurrent measurement of ten cytokines and their respective ratios using cytometric bead array.	16596275
Graft-vs-Host Disease	Stem Cell Exhaustion	Eight patients with aGVHD and eight without who had undergone allogeneic HLA-identical peripheral blood stem cell transplantation were studied.	16596275
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic hematopoietic stem cell transplantation using HLA-identical sibling donors in myelodysplastic syndromes.	16597592
Multiple Myeloma	Stem Cell Exhaustion	Maintenance therapy with thalidomide improves overall survival after autologous hematopoietic progenitor cell transplantation for multiple myeloma.	16598756
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy with autologous hematopoietic progenitor cell (HPC) transplantation improves survival for patients with multiple myeloma (MM); however, most patients develop recurrent disease after undergoing transplantation, and new treatment approaches are needed.	16598756
Bronchial Obstruction	Stem Cell Exhaustion	Considering obstructive patients, significant correlations were found between progenitor cell levels and bronchial obstruction and between progenitor cell levels and arterial oxygen tension.	16601079
Lung diseases	Stem Cell Exhaustion	Circulating progenitor cells are reduced in patients with severe lung disease.	16601079
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Autologous stem cell transplantation in acute myeloid leukemia.	16611537
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We report our results of autologous stem cell transplantation (SCT) in patients with AML during the last 13 years.	16611537
Prostate, Prostate carcinoma	Stem Cell Exhaustion	Autologous DC of HLA-A*0201(+) patients with hormone-refractory prostate cancer were loaded with antigenic peptides derived from prostate stem cell antigen (PSCA(14-22)), prostatic acid phosphatase (PAP(299-307)), prostate-specific membrane antigen (PSMA(4-12)), and prostate-specific antigen (PSA(154-163)).	16612599
Central neuroblastoma	Stem Cell Exhaustion	[Long-term effect of high dose chemotherapy combined with stem cell transplantation on stage IV neuroblastoma in children].	16613697
Central neuroblastoma	Stem Cell Exhaustion	This study aimed to explore the long-term effect of high dose induction chemotherapy combined with autologous peripheral blood stem cell transplantation and 13-cis retinoid acid treatment on stage IV neuroblastoma in children.	16613697
Central neuroblastoma	Stem Cell Exhaustion	High dose chemotherapy combined with autologous peripheral stem cell transplantation and 13 cis-retinoid acid treatment can improve the long-term outcome of patients with stage IV neuroblastoma.	16613697
Neoplasms	Stem Cell Exhaustion	During chemotherapy the autologous peripheral blood stem cells were harvested and the tumor excision was done.	16613697
Myelitis, Hodgkin Disease	Stem Cell Exhaustion	Treatment related myelitis in Hodgkin's lymphoma following stem cell transplant, chemotherapy and radiation: a case report and review of the literature.	16617406
Spinal Cord Diseases	Stem Cell Exhaustion	We report here a case of a 25-year-old Middle Eastern man with progressive myelopathy 21 months following low dose irradiation of the cord in the context of high dose chemotherapy and stem cell rescue and a review of the literature.	16617406
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Successful treatment of relapsed AML after allogeneic stem cell transplantation with azacitidine.	16620971
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Therapeutic options for patients with relapse of MDS or high risk AML after allogeneic stem cell transplantation are limited.	16620971
PAFAH1B1 wt Allele	Stem Cell Exhaustion	We here present the case of a 64-year-old female patient with MDS, who received peripheral blood stem cells from her HLA-identical brother after a non-myeloablative conditioning regimen.	16620971
NCI CTEP SDC Adrenal Cancer Sub-Category Terminology, Secondary Neoplasm	Stem Cell Exhaustion	Intensive multimodality therapy including paclitaxel and reduced-intensity allogeneic hematopoietic stem cell transplantation in the treatment of adrenal cancer with multiple metastases.	16622753
Adrenocortical carcinoma	Stem Cell Exhaustion	Although this experience is limited, we suggest that TIP chemotherapy was effective for adrenocortical carcinoma, and a graft-versus-tumor effect after reduced-intensity stem cell transplantation may have contributed to the prolonged survival.	16622753
Toothache	Stem Cell Exhaustion	The men had tooth pain from the beginning of the chemotherapy, but the extraction was performed till one month before high dose chemotherapy with peripheral stem cell transplantations, when the conservative therapy was find unsatisfactory.	16623282
Acute leukemia	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplants or relapsed acute leukemia defined high-risk patients.	16623818
Sinusitis, Aplastic Anemia	Stem Cell Exhaustion	Successful treatment with allogeneic peripheral blood stem cell transplantation and granulocyte transfusion for severe aplastic anemia with sinusitis.	16623820
Communicable Diseases	Stem Cell Exhaustion	Because of the necessity for early neutrophil recovery (to resolve the infection), we proceeded with a combination therapy using allogeneic peripheral blood stem cell transplantation (PBSCT) promptly followed by granulocyte transfusion (GTX) from the same human leukocyte antigen-identical donor rather than carrying out a second immunosuppressive therapy.	16623820
Hemorrhagic cystitis	Stem Cell Exhaustion	[Risk factors and treatment of hemorrhagic cystitis in children after hematopoietic stem cell transplantation].	16624030
Cessation of life, Kidney Failure, CLTC gene, Hemorrhagic cystitis, Usual Severity Pain	Stem Cell Exhaustion	Hemorrhagic cystitis (HC) is one of the common complications of hematopoietic stem cell transplantation (HSCT), which causes significant pain, prolongs hospitalization, and occasionally results in renal failure and death.	16624030
CLTC gene	Stem Cell Exhaustion	This study aimed at investigating the incidence, risk factors, and outcome of HC in children post umbilical cord blood transplantation (UCBT) and peripheral blood stem cell transplantation (PBSCT).	16624030
leukemia	Stem Cell Exhaustion	[The outcomes of the thirty patients with refractory leukemia treated with related HLA haploidentical stem cells transplantation].	16624123
leukemia	Stem Cell Exhaustion	To assess the outcomes of the therapy for patients with refractory leukemia with HLA haploidentical stem cells transplantation.	16624123
leukemia	Stem Cell Exhaustion	To analyze the outcomes of 30 patients with refractory leukemia who underwent HLA haploidentical peripheral blood stem cells transplantation from August 1998 to August 2004.	16624123
Myeloid Leukemia, Chronic, Lymphoma, Non-Hodgkin, leukemia, BCR gene, Leukemia, Myelocytic, Acute, Acute lymphocytic leukemia	Stem Cell Exhaustion	Thirty refractory leukemia patients including 13 cases of acute non-lymphocytic leukemia, 10 cases of acute lymphocytic leukemia (ALL), 6 cases of chronic myeloid leukemia and 1 case of phase IV non-Hodgkin's lymphoma underwent HLA haploidentical peripheral blood stem cells transplantation.	16624123
leukemia	Stem Cell Exhaustion	It is concluded from our observation that HLA haploidentical peripheral blood stem cells transplantation may be an effective therapy for refractory and relapse leukemia.	16624123
leukemia	Stem Cell Exhaustion	Some patients with refractory and relapse leukemia treated with HLA haploidentical stem cells transplantation may have disease free survival.	16624123
leukemia	Stem Cell Exhaustion	Graft versus leukemia effect may be strong in patients receiving HLA haploidentical blood stem cells transplantation and leukemia will probably be relapsed when the patient without complete remission was treated with this therapy.	16624123
Hyperhomocysteinemia	Stem Cell Exhaustion	Reduced number and activity of circulating endothelial progenitor cells from patients with hyperhomocysteinemia.	16624647
Acute myocardial infarction	Stem Cell Exhaustion	[Safety and efficacy of intracoronary transplantation of G-CSF mobilized autologous peripheral blood stem cells in patients with acute myocardial infarction].	16626571
Acute myocardial infarction	Stem Cell Exhaustion	To investigate the safety and efficacy of intracoronary transplantation of G-CSF mobilized autologous peripheral blood stem cells in patients with acute myocardial infarction (AMI).	16626571
Dilated Cardiomyopathy Pathway	Stem Cell Exhaustion	[A prospective, randomized, controlled trial of autologous mesenchymal stem cells transplantation for dilated cardiomyopathy].	16626573
Cardiomyopathy, Familial Idiopathic	Stem Cell Exhaustion	This study was performed to explore the efficacy and safety of intracoronary autologous mesenchymal stem cells (MSCs) transplantation for treating patients with idiopathic dilated cardiomyopathy.	16626573
Cardiomyopathy, Familial Idiopathic	Stem Cell Exhaustion	Twenty-four consecutive patients with idiopathic dilated cardiomyopathy received standard drug therapy were randomly divided into intracoronary injection of autologous mesenchymal stem cells (treated, n = 12) or saline (control, n = 12) groups.	16626573
Cardiomyopathy, Familial Idiopathic	Stem Cell Exhaustion	Percutaneous coronary autologous mesenchymal stem cells transplantation can attenuate the increase of plasma BNP, increase six-minute-walking capacity in patients with idiopathic dilated cardiomyopathy.	16626573
Bone Marrow, Multiple Myeloma	Stem Cell Exhaustion	Although alkylating agents are clearly beneficial in multiple myeloma (MM), their deleterious effect on bone marrow hematopoietic progenitor cells usually precludes their use as front-line therapy in patients scheduled to undergo autologous stem cell transplantation (ASCT).	16627253
Left-Sided Heart Failure	Stem Cell Exhaustion	Cardiac uptake of progenitor cells in patients with moderate-to-severe left ventricular failure scheduled for cardiac resynchronization therapy.	16627431
Adrenal Gland Lymphoma	Stem Cell Exhaustion	After irradiation of both adrenal lymphomas and CHOP therapy accompanied by intrathecal treatment and rituximab, the patient underwent a left adrenalectomy and high-dose chemotherapy with autologous peripheral blood stem cell transplantation.	16629485
Ulcerative Colitis	Stem Cell Exhaustion	In heterozygotes, we previously demonstrated wholly mPAS-positive (stem cell mutated) crypts and clusters of two or more mPAS-positive crypts to be significantly increased with duration of ulcerative colitis.	16630132
Gastrointestinal mucositis, Multiple Myeloma	Stem Cell Exhaustion	A prospective, randomized study of cryotherapy during administration of high-dose melphalan to decrease the severity and duration of oral mucositis in patients with multiple myeloma undergoing autologous peripheral blood stem cell transplantation.	16633359
Multiple Myeloma	Stem Cell Exhaustion	Forty patients with multiple myeloma scheduled to receive melphalan 200 mg/m(2) followed by autologous stem cell transplantation were randomly assigned to receive oral cryotherapy or room temperature normal saline rinses 30 min before and for 6 h after high-dose therapy.	16633359
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation for older patients with relapsed non-Hodgkin's lymphoma.	16633361
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	To evaluate autologous stem cell transplant (ASCT) in older patients with intermediate grade non-Hodgkin's lymphoma (NHL), the Mayo Clinic Rochester BMT database was reviewed for all patients 60 years of age and older who received ASCT for NHL between September 1995 and February 2003.	16633361
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	Autologous stem-cell transplant can be safely performed in patients 60 years or older with chemotherapy sensitive relapsed or first partial remission NHL.	16633361
Allogeneic Hematopoietic Stem Cell Transplantation, Chronic graft-versus-host disease	Stem Cell Exhaustion	Altered functional status of the hypothalamic dopaminergic tone in patients with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation: a pilot study.	16635792
Graft-vs-Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	We compared the functional status of the hypothalamic dopaminergic tone in patients given an allogeneic hematopoietic stem cell transplantation (allo-HSCT) with chronic graft-versus-host disease (GVHD) with that observed in patients with allo-HSCT without chronic GVHD and in healthy controls.	16635792
Myeloid, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Fifty-six patients with myelodysplastic syndrome and other myeloid disorders underwent transplantation with peripheral blood progenitor cells from related (n=30) or unrelated (n=26) donors.	16635793
Graft-vs-Host Disease	Stem Cell Exhaustion	Thus, THY 4.5 to 6.0 mg/kg seemed beneficial for GVHD prevention in BUCY-conditioned patients who underwent transplantation with peripheral blood progenitor cells, although relapse-free survival did not differ significantly from that in comparable historical controls not given THY.	16635793
Systemic Scleroderma	Stem Cell Exhaustion	Successful autologous peripheral blood stem cell transplantation using thiotepa in a patient with systemic sclerosis and cardiac involvement.	16636524
Systemic Scleroderma, Sample Size Calculation, Scleroderma	Stem Cell Exhaustion	A 19-year-old man with systemic sclerosis (SSc) was hospitalized for autologous peripheral blood stem cell transplantation (auto-PBSCT) due to progressive scleroderma and cardiac involvement despite conventional treatment.	16636524
Congestive heart failure	Stem Cell Exhaustion	During the administration of cyclophosphamide (60 mg/kg/day for 2 days) for mobilization and collection of CD34+ selected peripheral blood stem cells, he developed congestive heart failure.	16636524
Hematologic Neoplasms, Hodgkin Disease, Multiple Myeloma	Stem Cell Exhaustion	To explore the efficacy and safety of high-dose of etoposide with granulocyte colony-stimulating factor (G-CSF) for mobilization of peripheral blood stem cells, 10 patients with hematologic malignancies including 6 patients with multiple myeloma and 4 with non Hodgkin' s lymphoma received an etoposide dose of 1.6 g/m2.	16638224
Hematologic Neoplasms	Stem Cell Exhaustion	[High-dose etoposide with granulocyte colony-stimulating factor for mobilization of autologous peripheral blood stem/progenitor cells in patients with hematologic malignancies].	16638224
Hematologic Neoplasms	Stem Cell Exhaustion	It is concluded that high-dose etoposide with G-CSF is an effective and safe mobilizing regimen for autologous peripheral blood stem progenitor cells in patients with hematologic malignancies.	16638224
B-Cell Lymphomas	Stem Cell Exhaustion	Rituximab long-term maintenance therapy after autologous stem cell transplantation in patients with B-cell non-Hodgkin's lymphoma.	16639571
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	Thus, Rituximab maintenance therapy after autologous peripheral blood stem cell transplantation (PBSCT) might represent an improvement in NHL therapy.	16639571
Neoplasms	Stem Cell Exhaustion	This tumor might have been induced by circulating stem cells; however, due to autologous bona marrow transplantation, this cannot be proven.	16639606
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 51-year old female underwent a matched unrelated hematopoiectic stem cell transplant for acute mylogenous leukemia.	16639690
Non-Metastatic Carcinoma	Stem Cell Exhaustion	Randomized trial of high-dose chemotherapy and autologous hematopoietic stem cell support for high-risk primary breast carcinoma: follow-up at 12 years.	16639731
Non-Metastatic Carcinoma	Stem Cell Exhaustion	The authors previously reported results from a randomized trial of standard-dose chemotherapy with combined 5-fluorouracil (1000 mg/m2 per cycle), doxorubicin (50 mg/m2 per cycle), and cyclophosphamide (500 mg/m2 per cycle) (FAC) versus FAC followed by high-dose chemotherapy (HDCT) and autologous stem cell support (ASCS) for patients with high-risk primary breast carcinoma.	16639731
Multiple Myeloma	Stem Cell Exhaustion	Cyclophosphamide mobilization does not improve outcome in patients receiving stem cell transplantation for multiple myeloma.	16640814
Multiple Myeloma, Purpura, Thrombotic Thrombocytopenic	Stem Cell Exhaustion	Patients with multiple myeloma who undergo autologous stem cell transplantation (ASCT) and exhibit a complete response (CR) have a superior overall survival and time to progression (TTP).	16640814
Cytomegalovirus Infections, Lymphoma, leukemia	Stem Cell Exhaustion	Cytomegalovirus (CMV) antigenemia (CMV-A) and CMV disease (CMV-D), known causes of morbidity and mortality among patients with leukemia and recipients of hematopoietic stem cell transplantations, are described sporadically in patients with lymphoma.	16640816
Amyotrophic Lateral Sclerosis	Stem Cell Exhaustion	Combined immunosuppressive agents or CD4 antibodies prolong survival of human neural stem cell grafts and improve disease outcomes in amyotrophic lateral sclerosis transgenic mice.	16644922
Amyotrophic Lateral Sclerosis, Antilymphocyte Serum	Stem Cell Exhaustion	Amyotrophic lateral sclerosis (ALS) is a target for cell-replacement therapies, including therapies based on human neural stem cells (NSCs).	16644922
Multiple Myeloma	Stem Cell Exhaustion	Serum concentrations of Dickkopf-1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation.	16646053
Monoclonal Gammopathy of Undetermined Significance, Gammopathy, Multiple Myeloma	Stem Cell Exhaustion	In this study, serum concentrations of DKK-1 were measured in 50 myeloma patients (32 at diagnosis and 18 before and after autologous stem cell transplantation (ASCT), 18 patients with monoclonal gammopathy of undetermined significance (MGUS), and 22 healthy controls.	16646053
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	No polarization of type 1 or type 2 precursor dendritic cells in peripheral blood stem cell collections of non-hodgkin's lymphoma patients mobilized with cyclophosphamide plus G-CSF, GM-CSF, or GM-CSF followed by G-CSF.	16646673
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Previously, we have shown that non-Hodgkin's lymphoma (NHL) patients receiving cyclophosphamide (CTX) plus granulocyte- macrophage (GM)-CSF, G-CSF or GM-CSF followed by G-CSF for stem cell collection, mobilize up to five-fold more mature CD80(+) DCs compared to CTX plus G-CSF mobilized patients.	16646673
Keratopathy	Stem Cell Exhaustion	To investigate whether peripheral corneal neovascularization in bullous keratopathy (BK) is due to conjunctivalization, a sign of limbal stem cell deficiency.	16647124
Renal carcinoma	Stem Cell Exhaustion	Allogeneic haematopoietic stem cell transplantation for metastatic renal carcinoma in Europe.	16648196
Renal Cell Carcinoma Pathway, Refractory Cytopenia of Childhood	Stem Cell Exhaustion	We evaluated the experience of allogeneic haematopoietic stem cell transplantation (HSCT) for renal cell carcinoma (RCC) in 124 patients from 21 European centres.	16648196
Chondromatosis	Stem Cell Exhaustion	A case of chondromatosis indicates a synovial stem cell aetiology.	16670157
Limbal stem cell deficiency	Stem Cell Exhaustion	A total of 121 KLALs performed in consecutive 85 eyes of 78 patients with total limbal stem-cell deficiency were analyzed retrospectively.	16670472
Multiple Myeloma	Stem Cell Exhaustion	High-dose melphalan (200 mg/m2) supported by autologous stem cell transplantation is safe and effective in elderly (>or=65 years) myeloma patients: comparison with younger patients treated on the same protocol.	16670701
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Limited information is available on the feasibility and efficacy of autologous stem cell transplantation (ASCT) in multiple myeloma (MM) patients >65 years of age.	16670701
Communicable Diseases	Stem Cell Exhaustion	This study was performed to determine the significance of cross-resistance to new azole drugs among C. glabrata isolates recovered as a cause of infection in azole-treated hematopoietic stem cell transplant (HSCT) recipients.	16672401
Wiskott-Aldrich Syndrome	Stem Cell Exhaustion	Stable mixed chimerism after hematopoietic stem cell transplantation in Wiskott-Aldrich syndrome.	16677369
WAS protein, human	Stem Cell Exhaustion	The only curative treatment for WAS is hematopoietic stem cell transplantation, especially in the presence of a matched sibling donor or matched unrelated donor.	16677369
Graft-vs-Host Disease, Hematologic Neoplasms	Stem Cell Exhaustion	Patients included 98/225 who had undergone hematopoietic stem cell transplantation (HSCT) (88/98 allogeneic), 48 with graft versus host disease (GVHD), and 83/225 who had received chemotherapy for hematologic malignancy.	16678903
Chronic active Epstein-Barr virus infection	Stem Cell Exhaustion	Successful report of reduced-intensity stem cell transplantation from unrelated umbilical cord blood in a girl with chronic active Epstein-Barr virus infection.	16679925
Epstein-Barr virus	Stem Cell Exhaustion	We describe an 8-year-old girl with chronic active Epstein-Barr virus (EBV) infection (CAEBV) who was treated successfully by reduced-intensity stem cell transplantation (RIST) from unrelated cord blood (CB).	16679925
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Between August 1993 and March 2003, 130 consecutive multiple myeloma (MM) patients eligible for high-dose treatment were offered a program including up-front autologous stem cell transplantation (ASCT) after conditioning with 200 mg/m(2) melphalan followed by a second ASCT in case of relapse or progression.	16680735
Multiple Myeloma	Stem Cell Exhaustion	Fixed-dose single agent pegfilgrastim for peripheral blood progenitor cell mobilisation in patients with multiple myeloma.	16681642
Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy and autologous peripheral blood progenitor cell transplantation is an effective treatment for multiple myeloma.	16681642
Multiple Myeloma	Stem Cell Exhaustion	The results of a phase II study of pegfilgrastim, administered as a single injection to mobilise autologous peripheral blood progenitor cells in patients with multiple myeloma, is reported.	16681642
Multiple Myeloma	Stem Cell Exhaustion	A single fixed dose of pegfilgrastim was effective in mobilising adequate peripheral blood progenitor cells in patients with multiple myeloma.	16681642
ALDH7A1 gene, Intraepidermal Route of Drug Administration	Stem Cell Exhaustion	EPD is a predominantly intraepidermal tumour with extensive involvement of adnexal structures and high recurrence rates suggesting a follicular stem cell origin.	16681689
ALDH7A1 gene	Stem Cell Exhaustion	These histological and immunohistochemical observations allow the following conclusions: (i) the small, flat, 'compressed' keratinocytes are an integral part of EPD; (ii) the dual cell population is reminiscent of sebaceous glands with mature sebocytes and germinative keratinocytes; (iii) since both cell types express cytokeratins typical for follicular differentiation, EPD may be a proliferation of adnexal stem cells residing in the infundibulo-sebaceous unit of hair follicles and adnexal structures.	16681689
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Interestingly, none of these genes were methylated in the purified CD34+ hematopoietic stem cells from the MDS patients.	16682076
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	These results indicate that hypermethylation of cell cycle control genes in MDS may occur late during the differentiation of myelodysplastic stem cells.	16682076
Neoplasms, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We investigated the number of circulating haematopoietic progenitor cells in 79 patients with CML and five patients with solid tumours who were treated with imatinib for at least 3 months.	16684124
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Bone marrow progenitor cells were assessed in a subgroup of 18 patients with CML after 12 months of imatinib treatment.	16684124
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Circulating progenitors of all classes were significantly decreased in CML up to 24 months of imatinib therapy compared with healthy controls (median progenitor cells in CML after 12 months: CFU-GM 62, range 0-2543; BFU-E 216, range 0-3259; CFU-GEMM 0, range 0-139; versus controls: CFU-GM 208, range 50-936; BFU-E 690, range 120-1862; CFU-GEMM 20, range 4-77; P < 0.001).	16684124
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Similar reductions in the number of progenitor cells derived from bone marrow were found in a subgroup of 18 patients with CML.	16684124
Neoplasms	Stem Cell Exhaustion	In patients with solid tumours the number of circulating progenitor cells was significantly lower under treatment with imatinib when compared with the controls.	16684124
Cerebral Infarction, Longitudinal, Lupus Vulgaris	Stem Cell Exhaustion	Autologous blood stem cell transplantation in refractory systemic lupus erythematodes with recurrent longitudinal myelitis and cerebral infarction.	16686265
Autoimmune Diseases	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation (ASCT) has the potential to eliminate autoreactive lymphocytes and may represent a therapeutic option for patients with refractory autoimmune diseases.	16686265
Neoplasms, Carcinoma, Transitional Cell	Stem Cell Exhaustion	Prostate stem cell antigen predicts tumour recurrence in superficial transitional cell carcinoma of the urinary bladder.	16686711
Carcinoma, Transitional Cell	Stem Cell Exhaustion	To evaluate the relationship between prostate stem cell antigen (PSCA) expression level in transitional cell carcinoma (TCC) of the urinary bladder and various clinicopathological features, including stage and grade; and to determine whether PSCA mRNA expression predicts disease recurrence in superficial (not muscle-invasive) TCC of the bladder.	16686711
Toxic effect	Stem Cell Exhaustion	Treatment of cytomegalovirus (CMV) disease after allogeneic hematopoietic stem cell transplantation (HSCT) is limited by toxicities of current antiviral drugs and the occurrence of drug resistant strains.	16688677
Juvenile Myelomonocytic Leukemia	Stem Cell Exhaustion	A 1S-year-old boy with juvenile myelo-monocytic leukemia (JMML) received an allogeneic HSCT with bone marrow stem cells from a mismatched, unrelated donor (MMUD, recipient and donor CMV-positive).	16688677
Coronary Arteriosclerosis	Stem Cell Exhaustion	Endothelial injury induced by coronary angioplasty triggers mobilization of endothelial progenitor cells in patients with stable coronary artery disease.	16689747
Diabetes	Stem Cell Exhaustion	However, endothelial progenitor cells (EPCs) from diabetes are dysfunctional and impaired in ischemia-induced neovascularization.	16689750
Hodgkin Disease, HD Term Type	Stem Cell Exhaustion	Advanced-stage or relapsed/refractory Hodgkin's disease (HD) has a poor prognosis despite aggressive chemotherapy regimens and the use of high-dose therapy with autologous stem cell support.	16690523
HD Term Type	Stem Cell Exhaustion	MVC regimen for HD is highly active, for both de novo and relapsed/refractory disease, with high response rates and survival that compare favourably with the results obtained by high-dose therapy with stem-cell transplantation.	16690523
Multiple Myeloma	Stem Cell Exhaustion	Prolonged responses after autologous stem cell transplantation in African-American patients with multiple myeloma.	16699527
Cyclic neutropenia, Infection	Stem Cell Exhaustion	Infections during neutropaenia contribute still significantly to mortality and morbidity after high-dose therapy and autologous stem cell transplantation.	16699528
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Autologous stem cell transplantation in patients with chronic lymphocytic leukaemia: the Finnish experience.	16699533
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Although autologous stem cell transplantation (ASCT) has gained some popularity as a treatment option in patients with chronic lymphocytic leukaemia (CLL), limited multicentre data are available on the feasibility and efficacy of this approach.	16699533
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Autologous stem cell transplantation is a feasible treatment option for CLL.	16699533
Carcinogenesis	Stem Cell Exhaustion	Sonic Hedgehog (SHh), one of the Hh family members promotes carcinogenesis in airway and pancreatic epithelia, is expressed in colonic stem cells.	16701100
Carcinogenesis	Stem Cell Exhaustion	As differentiated colonic cells arise from constant renewal of Hedgehog-expressing colonic stem cells, SHh could be involved in human colonic carcinogenesis.	16701100
Neoplasms	Stem Cell Exhaustion	Since high-dose therapy (HDT) with autologous stem cell transplantation (ASCT) can cure a proportion of such patients, provided that a substantial tumor shrinkage is achieved, the development of more effective and less toxic salvage regimens remains a major challenge.	16702180
Aggressive course	Stem Cell Exhaustion	Based on the results of this pilot study, we conclude that the R-GIFOX regimen is feasible, tolerable, effective and able to mobilize peripheral stem cells in patients with relapsed and refractory aggressive NHL.	16702180
Lymphoma	Stem Cell Exhaustion	We have treated 75 transplant-eligible patients with relapsed or refractory lymphoma using an outpatient-based fractionated regimen of ifosfamide, carboplatin and etoposide (ICE) for both salvage and stem cell mobilisation.	16702181
nervous system disorder, Traumatic AND/OR non-traumatic injury	Stem Cell Exhaustion	Although limited clinical trials of stem cell therapy have been initiated in a number of neurological disorders, the preclinical evidence of a cell-based therapy for neonatal HI injury remains in its infancy.	16703953
Hypoxic-Ischemic Encephalopathy	Stem Cell Exhaustion	Transplantation of cryopreserved human bone marrow-derived multipotent adult progenitor cells for neonatal hypoxic-ischemic injury: targeting the hippocampus.	16703953
Aplastic Anemia	Stem Cell Exhaustion	Severe aplastic anaemia (SAA) can be successfully treated with immunosuppressive therapies or haematopoietic stem cell transplantation (HSCT).	16704434
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Timing of autologous stem cell transplantation from last chemotherapy affects lymphocyte collection and survival in non-Hodgkin lymphoma.	16704437
Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Autograft absolute lymphocyte count (A-ALC) is a prognostic factor for survival in non-Hodgkin lymphoma (NHL) after autologous stem cell transplantation (ASCT).	16704437
Monoclonal Gammopathy of Undetermined Significance, Multiple Myeloma, Plasma Cell Neoplasm	Stem Cell Exhaustion	Frequent gain of chromosome band 1q21 in plasma-cell dyscrasias detected by fluorescence in situ hybridization: incidence increases from MGUS to relapsed myeloma and is related to prognosis and disease progression following tandem stem-cell transplantation.	16705089
Specialty Type - cancer	Stem Cell Exhaustion	A retrospective review was conducted to determine the effect of a fixed 3 mg dose of rasburicase in 43 adult patients with cancer undergoing hematopoietic stem cell transplantation or receiving chemotherapy who had elevated or rising uric acid levels (6.4-16.8 mg/dl; median 9.6).	16708061
Multiple Myeloma	Stem Cell Exhaustion	Early lymphocyte recovery predicts longer survival after autologous peripheral blood stem cell transplantation in multiple myeloma.	16708062
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	To understand the prognostic value of lymphocyte recovery after autologous peripheral blood stem cell transplantation (APBSCT), we performed a retrospective study of 59 newly diagnosed multiple myeloma (MM) patients who underwent frontline APBSCT.	16708062
Richters syndrome	Stem Cell Exhaustion	Clinical outcomes and prognostic factors in patients with Richter's syndrome treated with chemotherapy or chemoimmunotherapy with or without stem-cell transplantation.	16710033
nervous system disorder, Traumatic AND/OR non-traumatic injury	Stem Cell Exhaustion	Limited clinical trials of stem cell therapy have been initiated in a number-of neurological disorders, but the preclinical evidence of a cell-based therapy for neonatal HI injury remains in its infancy.	16719058
Traumatic AND/OR non-traumatic injury	Stem Cell Exhaustion	An equally major finding is the observation lending support to the hippocampus as an excellent target brain region for stem cell therapy in treating HI injury.	16719058
Hypoxic-Ischemic Encephalopathy	Stem Cell Exhaustion	Behavioral and histological characterization of intrahippocampal grafts of human bone marrow-derived multipotent progenitor cells in neonatal rats with hypoxic-ischemic injury.	16719058
Aspergillosis	Stem Cell Exhaustion	Impact of the intensity of the pretransplantation conditioning regimen in patients with prior invasive aspergillosis undergoing allogeneic hematopoietic stem cell transplantation: A retrospective survey of the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation.	16720833
Aspergillosis	Stem Cell Exhaustion	In this retrospective study, we analyzed the outcomes of 129 patients who underwent an allogeneic hematopoietic stem cell transplantation (allo-HSCT) and had a history of probable or proven invasive aspergillosis (IA), of whom 57 (44%) received a reduced-intensity conditioning (RIC).	16720833
Cytomegalovirus Infections, Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	In addition, (4) conventional myeloablative conditioning increased the risk of progression early after transplantation (before day 30) only, while 3 variables increased the risk beyond day 30 were (5) cytomegalovirus disease; (6) bone marrow or cord blood as source of stem cells; and (7) grades II to IV acute graft-versus-host disease (GVHD).	16720833
Specialty Type - cancer	Stem Cell Exhaustion	Stem cell aging and cancer.	16723637
Specialty Type - cancer	Stem Cell Exhaustion	Studies aiming to identify and characterize these putative cancer stem cells and to understand how they arise will shed light on the process of stem cell aging and its role in cancer.	16723637
Specialty Type - cancer	Stem Cell Exhaustion	Aging at the interface of stem cell renewal, apoptosis, senescence, and cancer.	16723639
Polycythemia Vera	Stem Cell Exhaustion	Stem cell transplantation for polycythemia vera.	16724311
Malignant neoplasm of endocrine gland	Stem Cell Exhaustion	The role of imatinib mesylate (Glivec) for treatment of patients with malignant endocrine tumors positive for c-kit or PDGF-R. Imatinib mesylate (IM), a small molecule that is a selective inhibitor of the ABL, platelet derived growth factor receptor (PDGFR-R) and stem cell ligand receptor (c-kit) tyrosine kinases (TK).	16728580
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Autologous graft-versus-host disease-like syndrome after an alemtuzumab-containing conditioning regimen and autologous stem cell transplantation for chronic lymphocytic leukemia.	16728696
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	A high incidence of autologous graft-versus-host-disease (auto-GVHD) was observed after an alemtuzumab-containing conditioning regimen and autologous stem cell transplantation (auto-SCT) for chronic lymphocytic leukemia (CLL).	16728696
Tears body substance	Stem Cell Exhaustion	Substance-P, vascular endothelial growth factor (VEGF), and stem cell factor (SCF) were measured in plasma and tears using ELISA, and circulating CD34(+) and c-kit(+) mononuclear cells (MNCs) by flow cytometry.	16732212
Pterygium	Stem Cell Exhaustion	Immunohistochemical analysis of pterygium showed strong progenitor cell marker immunoreactivities.	16732212
Pterygium	Stem Cell Exhaustion	Endothelial progenitor cells in pterygium pathogenesis.	16732212
Pterygium	Stem Cell Exhaustion	We investigated whether endothelial progenitor cells (EPCs) are involved in pathogenesis of pterygium and the mechanism underlying the selective recruitment of EPCs during this process.	16732212
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Expression of bcr-abl mRNA and MMR genes mRNA were detected by RT-PCR in 26 CML patients with allogeneic peripheral blood stem cell transplantation (allo-PBSCT) and 4 CML patients on imatinib treatment.	16732964
Malignant neoplasm of testis	Stem Cell Exhaustion	A 33-year-old man with advanced testicular cancer underwent high-dose chemotherapy combined with peripheral blood stem cell transplantation.	16734883
Discordance	Stem Cell Exhaustion	This discordance is attributable to apoptosis of erythroid precursors derived from progenitor cells with an active X-chromosome bearing the ALAS2 mutation.	16735131
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Double induction containing either two courses or one course of high-dose cytarabine plus mitoxantrone and postremission therapy by either autologous stem-cell transplantation or by prolonged maintenance for acute myeloid leukemia.	16735702
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	A total of 1,770 patients (age 16 to 85 years) with de novo or secondary AML or high-risk myelodysplastic syndrome (MDS) were randomly assigned upfront for induction therapy containing one course with standard dose and one course with high-dose cytarabine, or two courses with high-dose cytarabine, and in the same step received postremission prolonged maintenance or busulfan/cyclophosphamide chemotherapy with autologous stem-cell transplantation.	16735702
Ischemic foot ulcer	Stem Cell Exhaustion	Stem cell use in a patient with an ischemic foot ulcer: a case study.	16737931
Peripheral Vascular Diseases	Stem Cell Exhaustion	Recent interest has focused on using adult stem cells isolated from a patient's bone marrow to stimulate the development of new blood vessels (a process called angiogenesis) in patients with peripheral vascular disease.	16737931
Usual Severity Pain, Ulcer	Stem Cell Exhaustion	The following case presentation will show how a patient with an ischemic toe ulcer and rest pain, who had no options for conventional revascularization, benefited from the injection of stem cells into her calf muscle.	16737931
Graft-vs-Host Disease	Stem Cell Exhaustion	We hypothesized that whole-body UV-B therapy would improve donor engraftment and decrease the incidence and severity of GVHD that is associated with decreased intensity allogeneic hematopoietic stem cell transplantation.	16737940
Encephalopathy, CTCAE 5.0, Neoplasms	Stem Cell Exhaustion	Severe encephalopathy after high-dose chemotherapy with autologous stem cell support for brain tumours.	16739345
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	ABCB1 modulation does not circumvent drug extrusion from primitive leukemic progenitor cells and may preferentially target residual normal cells in acute myelogenous leukemia.	16740770
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myelogenous leukemia (AML) is a disease originating from normal hematopoietic CD34+ CD38- progenitor cells.	16740770
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	These data argue that ABCB1 modulation is not an effective strategy to circumvent drug extrusion from primitive leukemic progenitor cells and may preferentially target residual normal progenitors in AML.	16740770
Mastocytosis	Stem Cell Exhaustion	Despite the relevance of the c-kit/stem cell factor (SCF) signaling pathway in mast cell (MC) diseases, the exact frequency of KIT mutations in different compartments of bone marrow (BM) hematopoietic cells of individuals with systemic mastocytosis (SM), and its different diagnostic categories, remains unknown.	16741248
Virus Diseases	Stem Cell Exhaustion	Poor T lymphocyte reconstitution limits the use of haploidentical stem cell transplantation (SCT) because it results in a high mortality from viral infections.	16741253
Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH) is a hematopoietic stem cell disorder characterized by the deficiency of glycosyl phosphatidylinositol (GPI)-anchored proteins in the affected blood cell membranes.	16751135
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	A serial analysis of a patient with PNH who underwent peripheral blood stem cell transplantation confirmed the usefulness of this method to evaluate PNH-affected RBC populations with high sensitivity; ie, the presence of CD59- reticulocytes in the circulation could be a sensitive marker for PNH-affected erythropoiesis.	16751135
Mycoses, Acute leukemia	Stem Cell Exhaustion	A prospective randomized trial of itraconazole vs fluconazole for the prevention of fungal infections in patients with acute leukemia and hematopoietic stem cell transplant recipients.	16751782
Mycoses	Stem Cell Exhaustion	Fluconazole antifungal prophylaxis is standard care in allogeneic hematopoietic stem cell transplant (HSCT) recipients, but this drug lacks anti-Aspergillus activity, the primary cause of invasive fungal infection (IFI) in many transplantation centers.	16751782
Hemolysis (biological function)	Stem Cell Exhaustion	While immune hemolysis due to donor isohemagglutinin (IH) production often complicates minor ABO incompatible peripheral blood hematopoietic stem cell transplantation (PBSCT), it is not known if this occurs with umbilical cord blood transplantation (UCBT).	16751785
Hematologic Neoplasms	Stem Cell Exhaustion	Does younger donor age affect the outcome of reduced-intensity allogeneic hematopoietic stem cell transplantation for hematologic malignancies beneficially?	16751789
Hematologic Neoplasms	Stem Cell Exhaustion	Our data suggest that younger donor age is associated with better outcome after sub-myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) for hematologic malignancies due to lower TRM and relapse.	16751789
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Transcoronary stem cell delivery using physiological endothelium-targeting perfusion technique: the rationale and a pilot study involving a comparison with conventional over-the-wire balloon coronary occlusions in patients after recent myocardial infarction.	16752333
Ischemia	Stem Cell Exhaustion	[Effective autologous bone marrow stem cell dosage for treatment of severe lower limb ischemia].	16752834
Ischemia	Stem Cell Exhaustion	To explore the effective autologous bone marrow stem cell dosage for treatment of severe lower limb ischemia.	16752834
Numbness, Cold Sensation, Usual Severity Pain	Stem Cell Exhaustion	A series of subjective indexes, such as improvement of pain, cold sensation and numbness, and objective indexes, such as increase of ankle/brachial index (ABI) and transcutaneous oxygen pressure (TcPO2), angiography, amputation rate, and improvement of foot wound healing were used to evaluate the effect of autologous bone marrow stem cells implantation.	16752834
Restenosis	Stem Cell Exhaustion	The effect of senescence of endothelial progenitor cells on in-stent restenosis in patients undergoing coronary stenting.	16755088
In-Stent Restenosis Indicator	Stem Cell Exhaustion	The objective of this study is to elucidate the relevance of endothelial progenitor cells (EPCs) in the development of in-stent restenosis in patients undergoing stent implantation.	16755088
Thrombotic Microangiopathies	Stem Cell Exhaustion	Risk factor analysis for thrombotic microangiopathy after reduced-intensity or myeloablative allogeneic hematopoietic stem cell transplantation.	16755559
Thrombomodulin Alfa, Thrombotic Microangiopathies	Stem Cell Exhaustion	Thrombotic microangiopathy (TMA) impairs long-term survival after allogeneic hematopoietic stem cell transplantation (HSCT).	16755559
Mantle cell lymphoma	Stem Cell Exhaustion	Efficacy of high-dose therapy and hematopoietic stem cell transplantation for mantle cell lymphoma.	16755570
Medial collateral ligament	Stem Cell Exhaustion	We report 30 hematopoietic stem cell transplants (HSCT) for MCL: 13 autologous, 10 allogeneic myeloablative, and 7 nonablative.	16755570
Thyroid dysfunction	Stem Cell Exhaustion	Thyroid dysfunction is a common complication after allogeneic hematopoietic stem cell transplantation (SCT).	16757437
Metapneumovirus, Malignant neoplasm of lung, Multiple Myeloma	Stem Cell Exhaustion	Human metapneumovirus infection in a hematopoietic stem cell transplant recipient with relapsed multiple myeloma and rapidly progressing lung cancer.	16757646
Malignant neoplasm of lung, Multiple Myeloma, Respiratory Tract Infections	Stem Cell Exhaustion	Human metapneumovirus (HMPV) was isolated from a 63-year-old multiple myeloma patient who had undergone hematopoietic stem cell transplantation and who presented with lower respiratory tract infection several weeks prior to the diagnosis of lung cancer.	16757646
Multiple Myeloma	Stem Cell Exhaustion	Prognostic factors for donor lymphocyte infusions following non-myeloablative allogeneic stem cell transplantation in multiple myeloma.	16757975
Multiple Myeloma	Stem Cell Exhaustion	In this retrospective study, we evaluated donor lymphocyte infusions given for relapsed (n=48) or persistent (n=15) myeloma following non-myeloablative allogeneic stem cell transplantation (Allo-SCT).	16757975
Chronic Lymphocytic Leukemia, Opportunistic Infections	Stem Cell Exhaustion	When compared with a concurrent chronic lymphocytic leukemia cohort that underwent allogeneic hematopoietic stem cell transplantation, alemtuzumab recipients had an incidence of cytomegalovirus reactivation of 66.7% (6 of 9 patients), compared with 37% in the non-alemtuzumab group (10 of 27 patients; P = .15), and an incidence of post-transplant opportunistic infections (excluding herpesviruses) of 44.4% (compared with 29.6% in the non-alemtuzumab group; P = .41).	16758413
Adenoma	Stem Cell Exhaustion	From the high frequency of various transcription factors, we also speculate that both null cell adenomas and GnSU-positive adenomas are derived from "committed" pituitary progenitor stem cells.	16760578
Intraepithelial Neoplasia	Stem Cell Exhaustion	The architectural alteration of proliferating cell and stem cell distribution in the layers of epithelial dysplasias may provide useful information to evaluate the grading of oral epithelial dysplasias.	16762018
Intraepithelial Neoplasia	Stem Cell Exhaustion	To evaluate the hypothesis that distributional alterations of proliferating and stem cells may be a useful index to estimate the grading and development of epithelial dysplasia, we examined the distribution patterns according to stratified cell layers.	16762018
Childhood Breast Carcinoma	Stem Cell Exhaustion	Immunotherapy of metastatic breast cancer: phase I trail of reduced-intensity allogeneic hematopoietic stem cell transplantation with Th2/Tc2 T-cell exchange.	16764750
Hematologic Neoplasms, Stomatitis	Stem Cell Exhaustion	Palifermin is a recombinant human keratinocyte growth factor approved to decrease the incidence and duration of severe oral mucositis in patients with hematologic malignancies who received myelotoxic therapy requiring hematopoietic stem cell support.	16765144
Pneumocystis jiroveci pneumonia, Specialty Type - cancer	Stem Cell Exhaustion	Influence of type of cancer and hematopoietic stem cell transplantation on clinical presentation of Pneumocystis jiroveci pneumonia in cancer patients.	16767486
Pneumocystis jiroveci pneumonia, Specialty Type - cancer	Stem Cell Exhaustion	Little is known about the impact of cancer type and hematopoietic stem cell transplantation on the presentation and outcome of P. jiroveci pneumonia in cancer patients.	16767486
Pneumothorax, Pleural Effusion, CTCAE, Neoplasms	Stem Cell Exhaustion	Pleural effusion and pneumothorax were more common in patients with hematopoietic stem cell transplantation than in those with solid tumors.	16767486
Cessation of life, Pneumocystis jiroveci pneumonia	Stem Cell Exhaustion	Death attributable to P. jiroveci pneumonia appeared to be higher in patients with hematopoietic stem cell transplantation.	16767486
Pneumocystis jiroveci pneumonia, Specialty Type - cancer	Stem Cell Exhaustion	The clinical presentation of P. jiroveci pneumonia in cancer patients may be affected by the category of cancer and the history of hematopoietic stem cell transplantation.	16767486
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The effect of allogeneic stem cell transplantation on outcome in younger acute myeloid leukemia patients with minimal residual disease detected by flow cytometry at the end of post-remission chemotherapy.	16769587
Lymphoma	Stem Cell Exhaustion	Prognostic value of FDG-PET scan imaging in lymphoma patients undergoing autologous stem cell transplantation.	16770314
Hodgkin Disease, Lymphoma, Non-Hodgkin, Lymphoma	Stem Cell Exhaustion	We conducted a retrospective analysis of 50 lymphoma patients (Hodgkin's disease and non-Hodgkin's lymphoma) who had an 18F-fluoro-deoxyglucose positron emission tomography (FDG-PET) scan after at least two cycles of salvage chemotherapy and before autologous stem cell transplantation (ASCT) at our institution.	16770314
Multiple Myeloma, Morular Metaplasia of the Endometrium, melphalan/prednisone protocol	Stem Cell Exhaustion	Standard first-line treatment for elderly multiple myeloma (MM) patients ineligible for stem cell transplantation is melphalan plus prednisone (MP).	16772605
Venoocclusive disease	Stem Cell Exhaustion	TIPS for veno-occlusive disease following stem cell transplantation.	16773513
Hepatic Veno-Occlusive Disease, Venoocclusive disease	Stem Cell Exhaustion	Hepatic veno-occlusive disease (VOD) is a complication of allogeneic blood stem cell transplantation (SCT).	16773513
Hematologic Neoplasms, leukemia	Stem Cell Exhaustion	Most patients (26; 93%) had haematological malignancies (19 had leukaemia); half (14) were allogeneic stem-cell transplant recipients.	16774557
Toxic effect	Stem Cell Exhaustion	Hyper-CVAD has substantial stem cell toxicity which can be readily circumvented by using the early chemotherapy cycles for mobilization.	16775841
Myeloproliferative disease, Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement	Stem Cell Exhaustion	Clonal evolution of 8p11 stem cell syndrome in a 14-year-old Chinese boy: a review of literature of t(8;13) associated myeloproliferative diseases.	16777224
Pulmonary Complication	Stem Cell Exhaustion	Pulmonary complications after hematopoietic stem cell transplantation.	16778380
Pulmonary Complication	Stem Cell Exhaustion	Despite advanced effective prophylaxes, pulmonary complications still occur in a high proportion of all hematopoietic stem cell recipients, accounting for considerable morbidity and mortality.	16778380
Pulmonary Complication	Stem Cell Exhaustion	The aim of our study was to describe the causes, incidences and mortality rates secondary to pulmonary complications and risk factors of such complications following hematopoietic stem cell transplantation (HSCT).	16778380
Neoplasms, Granulocytic Sarcoma	Stem Cell Exhaustion	Granulocytic sarcoma is a rare extramedullary tumor composed of myeloid progenitor cells.	16778404
Leukemia, T-Cell	Stem Cell Exhaustion	She suffered from adult T-cell leukemia and received peripheral blood stem cell transplantation (PBSCT).	16780100
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Fifty-one consecutive patients with MDS or sAML received this RIC regimen and URD (n = 30) or RD (n = 21) stem cells.	16785064
Hematologic Neoplasms	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (SCT) may cure patients with hematologic malignancies, but it carries significant risks.	16785065
Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Improved outcomes in intermediate- and high-risk aggressive non-Hodgkin lymphoma after autologous hematopoietic stem cell transplantation substituting intravenous for oral busulfan in a busulfan, cyclophosphamide, and etoposide preparative regimen.	16785066
Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Forty-nine patients with intermediate- and high-risk aggressive non-Hodgkin lymphoma underwent autologous hematopoietic stem cell transplantation (autoHSCT) using the regimen of busulfan (Bu), cyclophosphamide (Cy), and etoposide (E) that was originally developed for allogeneic HSCT.	16785066
Lupus Erythematosus	Stem Cell Exhaustion	Granulocytic invasion of the central nervous system after hematopoietic stem cell transplantation for systemic lupus erythematosus.	16785140
Myelitis, Transverse, Neurologic Symptoms, Lupus Vulgaris	Stem Cell Exhaustion	We report on the likely mechanism of an exacerbation of neurological symptoms developed during immune reconstitution after autologous non-myeloablative hematopoietic stem cell transplantation in a 33-year-old man with systemic lupus erythematosus- associated recurrent transverse myelitis.	16785140
Mucopolysaccharidoses	Stem Cell Exhaustion	[Allogeneic hematopoietic stem cell transplantation for the treatment of mucopolysaccharidosis type 1: a case report].	16787585
Pfaundler-Hurler Syndrome	Stem Cell Exhaustion	This study reported the therapeutic effect of allogeneic hematopoietic stem cell transplantation (allo-HSCT) on Hurler syndrome in one case.	16787585
Graft-vs-Host Disease	Stem Cell Exhaustion	Human granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood stem cells (CD34+ cells 12.8 x10(6)/kg) were infused and cyclosporine (CSA), short-course methotrexate, daclizumab and mycophenolate mofetil (MMF) were administered to prevent graft-versus-host disease (GVHD).	16787585
Graft-vs-Host Disease	Stem Cell Exhaustion	Sufficient immunosuppressive therapy and adequate hematopoietic stem cells infusion may be beneficial to the donor cell engraftment and reducing the incidence of graft failure and GVHD.	16787585
Aplastic Anemia	Stem Cell Exhaustion	Stable response after administration of stem cell factor combined with granulocyte colony-stimulating factor in aplastic anemia.	16787870
Aplastic Anemia	Stem Cell Exhaustion	We report successful treatment with 25 microg/kg of recombinant methionyl human stem cell factor (SCF) combined with 400 microg/m2 of recombinant human granulocyte colony-stimulating factor (G-CSF) in 2 patients with aplastic anemia refractory to immunosuppressive therapy.	16787870
Nephrotic Syndrome	Stem Cell Exhaustion	Treatment with candesartan combined with angiotensin-converting enzyme inhibitor for immunosuppressive treatment-resistant nephrotic syndrome after allogeneic stem cell transplantation.	16787879
Nephrotic Syndrome	Stem Cell Exhaustion	Most cases of nephrotic syndrome following stem cell transplantation (SCT) occur 6 months after SCT.	16787879
Cytomegalovirus Infections	Stem Cell Exhaustion	Evaluation of the COBAS Amplicor HCMV Monitor for early detection and monitoring of human cytomegalovirus infection after allogeneic stem cell transplantation.	16788683
Communicable Diseases	Stem Cell Exhaustion	Early diagnosis of human cytomegalovirus (HCMV) infection and the introduction of preemptive antiviral therapy have reduced HCMV-related mortality after allogeneic stem cell transplantation.	16788683
Multiple Myeloma	Stem Cell Exhaustion	Endothelial progenitor cells display clonal restriction in multiple myeloma.	16790068
Nephrotic Syndrome, Chronic graft-versus-host disease	Stem Cell Exhaustion	This is a case report of nephrotic syndrome as a manifestation of chronic GVHD developed after stem-cell transplantation.	16791603
Burn injury, Alkalies, corneal melt	Stem Cell Exhaustion	This case concerns the right eye of a 36-year-old male who had suffered from severe ocular alkali chemical burns and sustained intractable corneal melting, despite receiving corneal transplants three times, a limbal stem cell transplantation once, a scleral graft twice, and amniotic membrane transplantation eight times.	16793561
Pleuropulmonary blastoma	Stem Cell Exhaustion	Autologous peripheral blood stem cell transplantation in a patient with relapsed pleuropulmonary blastoma.	16794508
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The crucial point of the ANLL NS 03 programme is to determine the optimal timing for the transplantation of allogeneic and autologous haematopoietic stem cells.	16796168
Pulmonary Aspergillosis	Stem Cell Exhaustion	Usefulness of sequential Aspergillus galactomannan antigen detection combined with early radiologic evaluation for diagnosis of invasive pulmonary aspergillosis in patients undergoing allogeneic stem cell transplantation.	16797366
Cessation of life	Stem Cell Exhaustion	From February 2002 to June 2004, 74 hemato-oncologic patients undergoing allogeneic stem cell transplantation were prospectively studied with serum AGA twice weekly from admission until death or discharge and weekly afterward when possible.	16797366
Purpura, Thrombotic Thrombocytopenic	Stem Cell Exhaustion	Its median value was 107% (range: 55-170%) in healthy volunteers, but was significantly lower in patients with TTP (acquired or familial) and in patients with hematopoietic stem cell transplantation.	16797677
Actual blood loss	Stem Cell Exhaustion	Blood loss intensifies hematopoiesis by increasing the level of hematopoietic growth factors while, at the same time, stimulating proliferation of osteogenic progenitor cells.	16797864
Osteoporosis, Actual blood loss	Stem Cell Exhaustion	The chain of events that converts continuous requiremental pressure on hematopoiesis into development of osteoporosis may be formulated as follows: on the one hand, blood loss creates developmental pressure on the hematopoietic system, augments production of hematopoietic growth factors with subsequent intensified proliferation of hematopoietic progenitor cells, increases the number of hematopoietic cells including osteoclasts, thus intensifying resorption of bone tissue and extension of hematopoietic territories.	16797864
Actual blood loss	Stem Cell Exhaustion	On the other hand, blood loss leads to stimulation of bone development, extensive proliferation of osteogenic progenitor cells resulting in increased numbers of osteoblasts, followed by new bone formation and, at the same time, increased production and maturation of osteoclasts which then enter the cycle of bone resorption.	16797864
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Hospital in the home (HITH) care following autologous stem cell transplantation for lymphoma and multiple myeloma.	16800218
Multiple Myeloma	Stem Cell Exhaustion	Advances in outpatient and supportive care and increased pressure on hospital bed usage has led to the investigation of hospital in the home (HITH) management following autologous haematologous stem cell transplantation (AutoHSCT) for patients with multiple myeloma or lymphoma.	16800218
Malignant Neoplasms	Stem Cell Exhaustion	It appears from this preliminary study that freshly collected cord blood transfusion may cause a transient transplant impact of transfused cord blood CD34 stem cells on the host without provoking clinical graft vs host disease due to a of background immune suppression in advanced malignancy.	16800261
Endometrial Stromal Sarcoma	Stem Cell Exhaustion	Recurrent endometrial stromal sarcoma after treatment with high-dose chemotherapy and autologous stem-cell support: A case report.	16800264
Endometrial Stromal Sarcoma	Stem Cell Exhaustion	The efficacy of high-dose chemotherapy plus transplantation of autologous hematopoetic stem cells in patients with endometrial stromal sarcomas is unknown.	16800264
MYELODYSPLASTIC SYNDROME, MSD gene, Acute leukemia	Stem Cell Exhaustion	Myelodysplastic syndromes (MSD) are acquired disorders of the bone marrow, characterized by defects in maturation and function of hematopoietic stem cells, ineffective hemopoiesis and risk of evolution to acute leukemia.	16802536
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Short- and long-term results after intracoronary stem cell transplantation in acute and chronic myocardial infarction].	16802553
Peripheral arterial occlusive disease	Stem Cell Exhaustion	[Transplantation of autologous adult bone marrow stem cells in patients with severe peripheral arterial occlusion disease].	16802554
Ischemic stroke	Stem Cell Exhaustion	We concluded that stress related to ischemic stroke triggers the mobilization of hematopoietic stem/progenitor cells from the bone marrow into peripheral blood.	16805134
Amyotrophic Lateral Sclerosis	Stem Cell Exhaustion	Autologous mesenchymal stem cells: clinical applications in amyotrophic lateral sclerosis.	16808883
Amyotrophic Lateral Sclerosis, Antilymphocyte Serum	Stem Cell Exhaustion	Our study was aimed to evaluate the feasibility and safety of intraspinal cord implantation of autologous mesenchymal stem cells (MSCs) in a few well-monitored amyotrophic lateral sclerosis (ALS) patients.	16808883
varicella zoster, Lymphoma, Non-Hodgkin, Gastritis	Stem Cell Exhaustion	Acute abdomen by varicella zoster virus induced gastritis after autologous peripheral blood stem cell transplantation in a patient with non-Hodgkin's lymphoma.	16809891
Aggressive Non-Hodgkin Lymphoma, Peripheral Blood Stem Cells	Stem Cell Exhaustion	We report on a 54-year-old male patient with an aggressive T cell non-Hodgkin's lymphoma with abdominal manifestation undergoing autologous peripheral blood stem cell transplantation after high-dose chemotherapy in April 2003.	16809891
Abdominal Pain	Stem Cell Exhaustion	This report demonstrates the importance of viral-induced gastritis in the differential diagnosis of severe abdominal pain in patients receiving autologous peripheral blood stem cell transplantation.	16809891
Hepatitis B, hepatitis C virus	Stem Cell Exhaustion	Prevalence, incidence and clinical outcome of hepatitis B virus and hepatitis C virus hepatitis in patients undergoing allogeneic hematopoietic stem cell transplantation between 2001 and 2004.	16818288
Hepatitis A	Stem Cell Exhaustion	The prevalence, incidence and clinical course of viral hepatitis were prospectively determined in consecutive recipients of T-cell depleted hematopoieic stem cell transplants (49 mismatched, 60 matched, mean age 38 years; range 11-65).	16818288
Graft-vs-Host Disease, PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	To determine the frequency and severity of steroid myopathy and other steroid related complications in patients with acute myeloid leukemia (AML)/myelodysplastic syndrome (MDS) who developed grade >or=2 aGVHD after allogeneic hematopoietic stem cell transplantation (HSCT), we performed a retrospective analysis.	16819437
Graft-vs-Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Acute and chronic graft-versus-host diseases (GVHD) are associated with increased morbidity and mortality after hematopoietic stem cell transplantation (HCT).	16819438
Acute myocardial infarction	Stem Cell Exhaustion	The impact of the capability of circulating progenitor cell to differentiate on myocardial salvage in patients with primary acute myocardial infarction.	16820559
Acute myocardial infarction	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPCs) are known to be involved in vasculogenesis and mobilized after acute myocardial infarction (AMI).	16820559
Restenosis	Stem Cell Exhaustion	In addition, the potential risk of restenosis associated with G-CSF-based stem cell therapy has not been evaluated in the setting of drug eluting stent (DES) implantation.	16820564
Restenosis	Stem Cell Exhaustion	G-CSF-based stem cell therapy with DES implantation is both feasible and safe, eliminating any potential for restenosis.	16820564
Electrocardiogram: myocardial infarction (finding), Acute myocardial infarction	Stem Cell Exhaustion	Differential effect of intracoronary infusion of mobilized peripheral blood stem cells by granulocyte colony-stimulating factor on left ventricular function and remodeling in patients with acute myocardial infarction versus old myocardial infarction: the MAGIC Cell-3-DES randomized, controlled trial.	16820564
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	The efficacy of intracoronary infusion of granulocyte colony-stimulating factor (G-CSF) mobilized peripheral blood stem cells (PBSCs) has not been compared between patients with acute (AMI) versus old myocardial infarction (OMI).	16820564
Aneurysm	Stem Cell Exhaustion	We examined aneurysm tissue and cultured cells for expression of transforming growth factor-beta1 to -beta3 (TGFbeta1 to 3), hyaluronan content, apoptosis, markers of cell migration, and infiltration of vascular progenitor cells (CD34).	16820603
Amyloidosis	Stem Cell Exhaustion	Outcome of autologous stem cell transplantation for AL amyloidosis in the UK.	16822290
Toxic effect, Amyloidosis	Stem Cell Exhaustion	High-dose chemotherapy with autologous stem cell transplantation (SCT) is widely used as a treatment for systemic AL amyloidosis, but its efficacy has not been proved and it has substantial toxicity in this setting.	16822290
Toxic effect, Renal Insufficiency, Multiple Myeloma	Stem Cell Exhaustion	The clinical outcome and toxicity of high-dose chemotherapy and autologous stem cell transplantation in patients with myeloma or amyloid and severe renal impairment: a British Society of Blood and Marrow Transplantation study.	16822294
Acute myocardial infarction	Stem Cell Exhaustion	The clinical study of autologous peripheral blood stem cell transplantation by intracoronary infusion in patients with acute myocardial infarction (AMI).	16822566
Acute myocardial infarction	Stem Cell Exhaustion	To investigate the effects and safety of autologous peripheral blood stem cell (PBSCs) transplantation by intracoronary infusion in patients with acute myocardial infarction (AMI).	16822566
Neoplasms	Stem Cell Exhaustion	The origin of spontaneous human brain tumors has been recently debated as originating from a stem rather than a progenitor cell.	16824702
Neoplasms, Specialty Type - cancer, Glioblastoma	Stem Cell Exhaustion	Based on the statistical distribution of a selected group of primary brain tumors, and on the clonality and field theory for cancer growth, we propose as plausible the contribution of progenitor cells in the origin of the most common brain tumors such as, pediatric, mixed (glial and neuronal), and the aggressive glioblastoma multiforme in adults.	16824702
Coronary Arteriosclerosis	Stem Cell Exhaustion	Circulating endothelial progenitor cells predict coronary artery disease severity.	16824855
Atherosclerosis	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPCs) may play an important role in the body's defense against atherosclerosis.	16824855
Coronary Arteriosclerosis, Myocardial Ischemia	Stem Cell Exhaustion	To assess the safety and effects of combined treatment with vascular endothelial growth factor-A(165) plasmid (VEGF-A(165)) and granulocyte- colony stimulating factor (G-CSF) mobilization of bone marrow stem cells in patients with severe chronic ischaemic heart disease (IHD).	16825290
PAFAH1B1 wt Allele, Aplastic Anemia	Stem Cell Exhaustion	We aimed to determine the frequency of TERC mutations in pediatric patients with aplastic anemia and MDS who required a hematopoietic stem cell transplant.	16825992
Bone marrow hypocellularity	Stem Cell Exhaustion	We obtained 284 blood samples from the National Donor Marrow Program Research Sample Repository from children and adolescents with bone marrow failure who underwent an unrelated stem cell transplant.	16825992
Bone marrow hypocellularity	Stem Cell Exhaustion	Screening for TERC gene mutations is unlikely to diagnose occult DC in children with severe bone marrow failure who require a hematopoietic stem cell transplant.	16825992
Carcinoma of glottis	Stem Cell Exhaustion	The pattern of beta1 integrin expression was also closely related to histologic differentiation (P=.008), although the association between response to radiotherapy and histologic differentiation was not significant The pattern of expression of beta1 integrin, which has been known as a stem cell marker of the epidermis, may be helpful in predicting the response to radiation in patients with early glottic carcinoma.	16826065
Hematologic Neoplasms, Acute GVH disease	Stem Cell Exhaustion	A high proportion of donor CD4+ T cells expressing the lymph node-homing chemokine receptor CCR7 increases incidence and severity of acute graft-versus-host disease in patients undergoing allogeneic stem cell transplantation for hematological malignancy.	16826221
Neoplasms	Stem Cell Exhaustion	These results suggest that, in OSCCs, secreted VEGF might promote escape from tumor immunity by inhibiting the differentiation of CD1a + DCs from progenitor cells and increasing the levels of dysfunctional CD83+ DCs.	16827115
Aplastic Anemia	Stem Cell Exhaustion	Aplastic anemia (AA) is a rare hematopoietic stem cell disease, which can be treated with horse antilymphocyte globulin (ALG) for patients not eligible for bone marrow transplantation.	16830141
Neoplasms	Stem Cell Exhaustion	Myelolipoma is a benign tumor, involving mature fat and hematopoietic stem cells.	16830297
Muscular Dystrophy, Tumor necrosis	Stem Cell Exhaustion	Mesoangioblasts, vessel-associated stem cells, were exposed to several cytokines, among which stromal- derived factor (SDF) 1 or tumor necrosis factor (TNF) alpha were the most potent in enhancing transmigration in vitro and migration into dystrophic muscle in vivo.	16831885
Facial Nerve Injuries	Stem Cell Exhaustion	On the 42nd day, autologous mesenchymal stem cell transplantation was performed after facial nerve trauma.	16832623
Facial paralysis	Stem Cell Exhaustion	Mesenchymal stem cells in iatrogenic facial nerve paralysis: a possible role in the future.	16832623
Lymphoma, Follicular	Stem Cell Exhaustion	Outpatient autologous hematopoietic stem cell transplantation for patients with relapsed follicular lymphoma.	16832675
Lymphoma, Follicular	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) has emerged as a viable option for the treatment of relapsed follicular non-Hodgkin's lymphoma.	16832675
Osteopenia	Stem Cell Exhaustion	Pamidronate reduces bone loss after allogeneic stem cell transplantation.	16835281
Osteopenia	Stem Cell Exhaustion	Rapid bone loss occurs from the proximal femur after allogeneic stem cell transplantation (alloSCT).	16835281
Graft-vs-Host Disease	Stem Cell Exhaustion	Phase 1/2 randomized, placebo-control trial of palifermin to prevent graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT).	16835378
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Palifermin, a recombinant human keratinocyte growth factor, was tested for potential benefits on acute graft-versus-host disease (GVHD) and hematopoietic recovery in allogeneic hematopoietic stem cell transplantation (HSCT) recipients.	16835378
Amyloidosis	Stem Cell Exhaustion	High-dose therapy and autologous hematopoietic stem cell transplantation for patients with primary systemic amyloidosis: a Center for International Blood and Marrow Transplant Research Study.	16835967
Amyloidosis	Stem Cell Exhaustion	To determine the outcome of high-dose therapy with autologous hematopoietic stem cell transplantation (HSCT) in patients with primary systemic amyloidosis reported to the Center for International Blood and Marrow Transplant Research (CIBMTR).	16835967
Histogenic Process	Stem Cell Exhaustion	Molecular analysis of the current case suggests the histogenesis from a common cell progenitor.	16836749
Febrile Neutropenia, leukemia	Stem Cell Exhaustion	We conducted a randomized-controlled, open-label, multicenter clinical trial among high-risk patients from 34 university-affiliated tertiary care medical centers in the United States, Canada, and Australia who were undergoing treatment for leukemia or hematopoietic stem cell transplantation and were hospitalized for empirical treatment of febrile neutropenic episodes.	16838234
Amyloidosis	Stem Cell Exhaustion	Autologous stem cell transplantation and IgM amyloidosis.	16840189
Amyloidosis	Stem Cell Exhaustion	High dose chemotherapy (HDC) followed by autologous stem cell transplant (ASCT) is an accepted form of treatment for patients with AL amyloidosis.	16840189
Amyloidosis	Stem Cell Exhaustion	The purpose of the current study is to review the outcomes of IgM AL amyloidosis patients treated with high dose chemotherapy and autologous stem cell transplant and compare them to the outcomes of all AL amyloidosis subtypes treated similarly.	16840189
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Seventy-seven courses of rituximab (corresponding to 317 rituximab infusions) given to 72 consecutive patients affected by non-Hodgkin's Lymphoma and treated at a single Center with rituximab, alone (nine cases), associated with chemotherapy (50) or with chemotherapy and autologous stem cell transplantation (18) were evaluated.	16840190
Infiltration, Hypogammaglobulinemia, Cytopenia	Stem Cell Exhaustion	Age, sex, histology, bone marrow infiltration, hypogammaglobulinemia, previous chemotherapy, autologous stem cell transplant, rituximab schedule and timing, rituximab doses were analysed as predictors for cytopenia; by multivariate analysis only a previous treatment with chemotherapy and more than four rituximab doses were significantly associated with a higher risk of post-rituximab delayed cytopenia.	16840190
Lymphoma	Stem Cell Exhaustion	Two patients, one with no response and subsequent allogeneic hematopoietic stem cell transplantation and one with progressive disease, died of lymphoma.	16840195
Growth	Stem Cell Exhaustion	PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling.	16846854
Neoplasms	Stem Cell Exhaustion	Excessive PDGF activation in the SVZ in stem cells is sufficient to induce hallmarks associated with early stages of tumor formation.	16846854
Harvesting of peripheral blood stem cells	Stem Cell Exhaustion	Clinical impact of a new automated system employed for peripheral blood stem cell collection.	16847939
Specialty Type - cancer	Stem Cell Exhaustion	We examined pre-mobilization blood CD34+ cell count to predict ability to mobilize adequate peripheral blood progenitor cells (PBPC) in 106 cancer patients and 36 allogeneic donors.	16850032
Failure, Pulmonary Aspergillosis, leukemia	Stem Cell Exhaustion	This antifungal, however, could lead to therapy failure as demonstrated by the case in this report of a 55-year-old patient, who eight months after the diagnosis of leukemia and successful allogenic hematopoietic stem cell transplantation (HSCT), succumbed to a fatal pulmonary aspergillosis infection, which resisted treatment with caspofungin.	16854185
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Cardiac effects within 3 months of BEAC high-dose therapy in non-Hodgkin's lymphoma patients undergoing autologous stem cell transplantation.	16856907
N-Terminal ProA-type Natriuretic Peptide Measurement	Stem Cell Exhaustion	Radionuclide ventriculography (RVG) and plasma natriuretic peptide (NT-proANP, NT-proBNP) measurements were performed simultaneously prior to BEAC at baseline (d - 7), 12 days (d + 12) and 3 months (m + 3) after stem cell infusion (D0).	16856907
Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	Successful father-to-son stem cell transplantation in a child with hemophagocytic lymphohistiocytosis using a reduced-intensity conditioning regimen.	16856932
Disease, Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	Hemophagocytic lymphohistiocytosis (HLH) is an uncommon disorder, usually lethal without allogeneic stem cell transplantation (SCT).	16856932
Disorder of eye due to diabetes mellitus	Stem Cell Exhaustion	Number and function of endothelial progenitor cells as a marker of severity for diabetic vasculopathy.	16857948
Impaired, Disorder of eye due to diabetes mellitus	Stem Cell Exhaustion	As endothelial progenitor cells (EPCs) are involved in neovasculogenesis and maintenance of vascular homeostasis, their impairment may have a role in the pathogenesis of diabetic vasculopathy.	16857948
Intrahepatic Route of Drug Administration, Hypoxia	Stem Cell Exhaustion	Portal vein entrance of splenic erythrocytic progenitor cells and local hypoxia of liver, two events cause intrahepatic splenosis.	16860491
Intrahepatic Route of Drug Administration, Traumatic rupture of spleen, Hypoxia	Stem Cell Exhaustion	Based on the susceptibility of the splenic erythropoiesis response to hypoxia and the inevitability of hypoxia caused by aging or pathological changes, we hypothesized that the two events caused the occurrence of the intrahepatic splenosis, the migration of the erythrocytic progenitor cells via the portal vein following traumatic splenic rupture, and the local induction of erythropoiesis by hypoxia.	16860491
Neutropenia, Graft-vs-Host Disease	Stem Cell Exhaustion	Along with underlying disease, hematopoietic stem cell transplantation, neutropenia, graft-versus-host disease or antifungal treatment, signs of IPA, and number or size of lesions were evaluated regarding outcome and radiologic dynamics.	16861545
Multiple Myeloma	Stem Cell Exhaustion	New staging systems can predict prognosis of multiple myeloma patients undergoing autologous peripheral blood stem cell transplantation as first-line therapy.	16864054
Waldenstrom Macroglobulinemia	Stem Cell Exhaustion	Autologous or allogeneic stem cell transplantation in patients with Waldenstrom's macroglobulinemia.	16864055
Waldenstrom Macroglobulinemia	Stem Cell Exhaustion	The role of hematopoietic stem cell transplantation (SCT) in Waldenstrom's macroglobulinemia (WM) has not been extensively studied.	16864055
Graft-vs-Host Disease, Hematologic Neoplasms	Stem Cell Exhaustion	A study of a reduced-intensity conditioning regimen followed by allogeneic stem cell transplantation for patients with hematologic malignancies using Campath-1H as part of a graft-versus-host disease strategy.	16864057
Hyperglycemia	Stem Cell Exhaustion	Hyperglycemia accelerated endothelial progenitor cell senescence via the activation of p38 mitogen-activated protein kinase.	16864945
Diabetes Mellitus	Stem Cell Exhaustion	Both the number and function of bone marrow-derived endothelial progenitor cells (EPCs) have been shown to be impaired in patients with diabetes mellitus.	16864945
Graft-vs-Host Disease, Allogeneic Hematopoietic Stem Cell Transplantation	Stem Cell Exhaustion	Nutritional support for patients suffering from intestinal graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.	16865687
Graft-vs-Host Disease, gastrointestinal	Stem Cell Exhaustion	Patients who exhibit gastrointestinal (GI) involvement due to graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (SCT) are often recommended to withhold oral intake (NPO) to avoid further damage to the GI mucosa.	16865687
herpesvirus 3, human, Communicable Diseases	Stem Cell Exhaustion	Varicella-zoster virus (VZV) infection of the central nervous system (CNS) is rare after hematopoietic stem cell transplantation (SCT).	16867908
Impaired, Sample Size Calculation, Scleroderma	Stem Cell Exhaustion	This study provides the first demonstration that in SSc, there is a complex impairment in the BM microenvironment involving both the endothelial and mesenchymal stem cell compartments and that this impairment might play a role in defective vasculogenesis in scleroderma.	16868984
Sample Size Calculation	Stem Cell Exhaustion	Since circulating endothelial progenitor cells (EPCs) are important in the vascular repair process, we undertook this study to examine their numbers in the peripheral blood (PB) of SSc patients and to evaluate whether their status is related to impaired quantitative and/or qualitative aspects of the bone marrow (BM) microenvironment.	16868984
Atherosclerosis	Stem Cell Exhaustion	Peripheral blood CD34+KDR+ endothelial progenitor cells are determinants of subclinical atherosclerosis in a middle-aged general population.	16873710
Mantle cell lymphoma, Multiple Myeloma	Stem Cell Exhaustion	The patients had received treatment for multiple myeloma or relapsed mantle cell lymphoma with high-dose treosulfan alone or in combination with etoposide and carboplatin followed by autologous stem cell transplantation 5 days before onset of the symptoms.	16874016
Hepatitis, Drug-Induced	Stem Cell Exhaustion	Rescue therapy by portal infusion of autologous stem cells in a case of drug-induced hepatitis.	16875890
Lymphoma, Secondary Myelodysplastic Syndrome, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Risk factors before autologous stem-cell transplantation for lymphoma predict for secondary myelodysplasia and acute myelogenous leukemia.	16877727
Therapy-related myelodysplastic syndrome, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	The risk factors for treatment-related myelodysplastic syndrome (t-MDS) and acute myelogenous leukemia (AML) after autologous stem-cell transplantation (ASCT) are similar to those that increase the risk of difficult stem-cell harvests.	16877727
Lymphoma	Stem Cell Exhaustion	We reviewed our experience in 526 patients with lymphoma treated by ASCT to determine whether difficult stem-cell harvests predict for an increased risk of t-MDS/AML.	16877727
Hodgkin Disease, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Pretransplantation characteristics, including age, diagnosis of non-Hodgkin's lymphoma or Hodgkin's disease, bone marrow involvement, prior radiation therapy, prior exposure to chemotherapy, lactate dehydrogenase at the time of ASCT, disease status, and method of stem-cell mobilization, were then analyzed with respect to the subsequent development of t-MDS/AML.	16877727
Peripheral Blood Stem Cells, Childhood Breast Carcinoma	Stem Cell Exhaustion	Breast cancer-specific mRNA transcripts presence in peripheral blood after adjuvant chemotherapy predicts poor survival among high-risk breast cancer patients treated with high-dose chemotherapy with peripheral blood stem cell support.	16877728
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Efficacy of single dose pegfilgrastim in enhancing the mobilization of CD34+ peripheral blood stem cells in aggressive lymphoma patients treated with cisplatin-aracytin-containing regimens.	16878144
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	We evaluated the efficacy of a single 6 mg dose of pegfilgrastim for mobilizing peripheral blood stem cells (PBSC) in aggressive lymphoma patients.	16878144
Hollings Cancer Center	Stem Cell Exhaustion	The expression of hepatocellular differentiation markers (Hepar, canalicular polyclonal carcinoembryonic antigen), biliary/progenitor cell markers (CK7, CK19), alpha-fetoprotein (AFP), p53 and beta-catenin in HCC was semiquantitatively assessed by immunohistochemistry.	16879391
Liver carcinoma, HCCS gene, Hollings Cancer Center	Stem Cell Exhaustion	Cytokeratin (CK) 7 and CK19 expression, present in hepatic progenitor cells (HPCs) and in cholangiocytes but not in normal hepatocytes, has been reported in some hepatocellular carcinomas (HCCs); however, the incidence and relevance of this expression in HCC in Caucasians is not known.	16879391
Lymphocyte Activation, Myelomonocyte	Stem Cell Exhaustion	This case clearly indicates that the blastic transformation in EMS with t(8;9) could arise in the stem cells, which differentiate into not only myelomonocytic but also B-lymphocytic lineages.	16879608
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Results of genoidentical hemopoietic stem cell transplantation with reduced intensity conditioning for acute myelocytic leukemia: higher doses of stem cells infused benefit patients receiving transplants in second remission or beyond--the Acute Leukemia Working Party of the European Cooperative Group for Blood and Marrow Transplantation.	16880451
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Nucleated cell dose is an important and modifiable factor in hematopoietic stem cell transplantation (HSCT), however its association with outcomes in the context of reduced intensity conditioning regimen (RIC) HSCT for adults with acute myelocytic leukemia (AML) is not known.	16880451
leukemia	Stem Cell Exhaustion	Among 19 patient samples, the relative level of the IL-3Ralpha was higher than the IL-3Rbeta(c) and highest in CD34(+)CD38(-)CD71(-) cells, enriched for candidate leukemia stem cells, compared with cell fractions depleted of such progenitors.	16882709
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Adult stem cell therapy is expected to improve left ventricular function in patients with myocardial infarction.	16883008
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Tissue distribution of 18F-FDG-labeled peripheral hematopoietic stem cells after intracoronary administration in patients with myocardial infarction.	16883008
Cardiac Arrhythmia	Stem Cell Exhaustion	Because of the low risk of arrhythmia and the maximal concentration at the target tissue, intracoronary infusion of stem cells is preferred.	16883008
Hematologic Neoplasms	Stem Cell Exhaustion	Haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion for the treatment of hematological malignancies.	16883312
Angioimmunoblastic Lymphadenopathy, Lymphoma, Chronic graft-versus-host disease	Stem Cell Exhaustion	A 72-year-old man with the angioimmunoblastic type of malignant lymphoma developed chronic GVHD after allogeneic peripheral blood stem cell transplantation.	16883364
Pituicytoma	Stem Cell Exhaustion	While the dynamic properties of the latter are incompletely characterized, and indeed no specific marker allows for their identification, overlapping features of SCO with look alikes, in particular pituicytoma, point to FSCs being a potential adult stem cell.	16884858
Bone necrosis	Stem Cell Exhaustion	Osteonecrosis after allogeneic stem cell transplantation in childhood.	16885050
Aggressive Non-Hodgkin Lymphoma, Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	Whether salvage therapy in patients with advanced aggressive non-Hodgkin's lymphoma (NHL) in partial remission (PR) should consist of radiotherapy or autologous stem-cell transplantation (ASCT) is debatable.	16887289
Multiple Myeloma	Stem Cell Exhaustion	High-dose therapy and autologous peripheral blood stem cells transplantation followed by a very low reduced intensity regimen with fludarabine + cyclophosphamide and allograft improve complete remission rate in de novo multiple myeloma patients.	16888786
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We evaluated the combination of high-dose therapy and autologous peripheral blood stem cells transplantation (APBSCT) followed by RICT to extend the benefit of allografting procedures in de novo multiple myeloma (MM) patients.	16888786
Acute myocardial infarction	Stem Cell Exhaustion	Stem cell mobilization with granulocyte colony-stimulating factor (G-CSF) has been proposed to improve cardiac function and prevent ventricular remodeling after acute myocardial infarction (AMI) in preclinical and clinical studies.	16891014
Acute myocardial infarction	Stem Cell Exhaustion	Effects of GM-CSF on the stem cells mobilization and plasma C-reactive protein levels in patients with acute myocardial infarction.	16891014
Lymphoma, Non-Hodgkin, Hypogammaglobulinemia	Stem Cell Exhaustion	Adjuvant rituximab causes prolonged hypogammaglobulinaemia following autologous stem cell transplant for non-Hodgkin's lymphoma.	16892074
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	Adjuvant immunotherapy with rituximab may reduce relapse rates for high-risk B-cell NHL following high-dose chemotherapy with autologous stem cell transplantation (SCT).	16892074
Angina Pectoris, Coronary Arteriosclerosis	Stem Cell Exhaustion	[Intramyocardial injection of autologous bone-marrow stem cells in a 74-year-old man with untreatable angina pectoris and demonstrated myocardial ischaemia].	16892617
Cytomegalovirus Infections, Acute lymphocytic leukemia, Malignant neoplasm of lung, Lupus Erythematosus, Multiple Myeloma, Myeloid Leukemia, Chronic, Chronic Lymphocytic Leukemia, Aspergillosis, Childhood Breast Carcinoma, Malignant neoplasm of ovary, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	The underlying diseases of the patients were lung cancer (n =4), breast cancer following autologous hematopoietic stem cell transplantation and acute myeloid leukemia (n=3 each), myelodysplastic syndrome (n=2), acute lymphoid leukemia, chronic lymphoid leukemia, chronic myeloid leukemia, multiple myeloma, ovarian cancer, aspergillosis, cytomegalovirus infection and systemic lupus erythematosus (n = 1 each).	16900790
Chronic myocardial ischemia	Stem Cell Exhaustion	Effects of granulocyte colony simulating factor on functional activities of endothelial progenitor cells in patients with chronic ischemic heart disease.	16902165
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Early allogeneic stem cell transplantation for chronic myelogenous leukemia in the imatinib era: a preliminary assessment.	16904348
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We have examined the role of early allogeneic hematopoietic stem cell transplantation in patients with chronic phase chronic myelogenous leukemia (CML) who enter a complete cytogenetic remission with imatinib mesylate.	16904348
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Three kinds of data were used to examine the effect of the outcome of current BCR-ABL inhibitor treatment compared to early allogeneic stem cell transplantation: (1) the life expectancy of the general population of the United States as a function of age, (2) the life expectancy of CML patients as a function of the age of patients treated with imatinib mesylate (imatinib) who achieve a complete cytogenetic remission, and (3) the life expectancy of patients with CML treated with matched-related or matched-unrelated stem cell transplantation as a function of age, derived from data provided by the Center for International Blood and Marrow Transplant Research (CIBMTR).	16904348
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We have calculated the projected life expectancy from the age at which patients with CML enter complete cytogenetic remission with imatinib and that of those who receive allogeneic stem cell transplantation.	16904348
Immune Reconstitution, Autoimmune state	Stem Cell Exhaustion	This case illustrates the role of deficiency of CD4+CD25+ Treg cells in causing autoimmunity, and speaks to the potential use of allogenic stem cell transplantation for immunoreconstitution in adult PBC.	16904870
leukemia	Stem Cell Exhaustion	It would therefore, appear that enzyme alterations seen in leukemia patients is due to abnormal pluripotent stem cell that has given to a leukemia cell.	16909693
Peripheral Stem Cell Transplantation, Testicular Neoplasms	Stem Cell Exhaustion	Clinical study for management of supportive treatment for high-dose chemotherapy with peripheral blood stem cell transplantation (PBSCT) for intractable testicular tumor.	16910585
Peripheral Stem Cell Transplantation, Testicular Neoplasms	Stem Cell Exhaustion	The side effects of high-dose anti-cancer drug chemotherapy with peripheral blood stem cell transplantation (PBCST) for the treatment of intractable testicular tumor are very serious.	16910585
Degenerative polyarthritis	Stem Cell Exhaustion	These findings indicate that multipotential mesenchymal progenitor cells are present in articular cartilage from adult humans and that their frequency is increased in OA.	16912416
Arthritis	Stem Cell Exhaustion	This observation has implications for understanding the intrinsic repair capacity of articular cartilage and raises the possibility that these progenitor cells might be involved in the pathogenesis of arthritis.	16912416
Thrombocytosis, Thrombocythemia, Essential	Stem Cell Exhaustion	Essential thrombocythemia (ET) is a clonal disorder of myeloid stem cells that causes thrombocytosis.	16913448
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	We investigated the efficacy of a dose-intensified double-CHOP regimen followed by high-dose chemotherapy with or without peripheral blood stem cell transplantation (PBSCT) in 11 patients with four types of peripheral T-cell lymphoma (PTCL).	16914902
Allogeneic Hematopoietic Stem Cell Transplantation	Stem Cell Exhaustion	The purpose of this article is to describe and illustrate the acute and follow-up imaging features, clinical constellation and outcome of patients with thoracic air-leakage syndrome following allogeneic hematopoietic stem cell transplantation (allo-HCT).	16916592
Aspergillus flavus allergenic extract	Stem Cell Exhaustion	A case report of an 8-year-old allogeneic stem cell transplant recipient who developed a central venous catheter tunnel infection caused by Aspergillus flavus is presented here.	16918062
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Presence of FLT3 mutations does not impair stem cell mobilization and feasibility of autologous peripheral blood stem cell transplantation in acute myeloid leukemia.	16920565
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Accordingly, FLT3 mutations may affect mobilization of peripheral blood stem cells (PBSCs) and feasibility of autologous stem cell transplantation (ASCT) in AML.	16920565
Mycoses	Stem Cell Exhaustion	Invasive fungal infections (IFI) are frequent causes of mortality after allogeneic stem-cell transplantation (SCT).	16922792
Fulminant Hepatitis, Hepatitis B	Stem Cell Exhaustion	Under immunosuppressive conditions after hematopoietic stem cell transplantation (HSCT), even if hepatitis B virus (HBV) antigen is negative but hepatitis B surface antibody (HBsAb) or hepatitis B core antibody (HBcAb) is presented, HBV reactivates and sometimes causes fulminant hepatitis.	16923112
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	High-dose rituximab does not negatively affect peripheral blood stem cell mobilization kinetics in patients with intermediate-grade non-Hodgkin's lymphoma.	16923559
B-Cell Lymphomas	Stem Cell Exhaustion	The purpose of this study was to study the effect of high-dose rituximab given with chemotherapy on stem cell mobilization in patients with intermediate-grade B-cell non-Hodgkin's lymphoma.	16923559
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	The purpose of this study was to compare the efficacy of rituximab given in combination with CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) and ESHAP (etoposide, methylprednisolone, high-dose Ara-C, cisplatin) vs CHOP-ESHAP and upfront high-dose therapy (HDT) and autologous stem cell transplantation (ASCT) vs standard CHOP in patients aged < or = 65 years old newly diagnosed with 'high' and 'high-intermediate' risk aggressive lymphoma enrolled onto two consecutive treatment trials at the institute.	16923561
Chromosome Aberrations, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The recent observation that clonal cytogenetic abnormalities may occur in CML patients in polyclonal remission after imatinib suggests that a neoplastic stem cell lacking BCR/ABL rearrangement may acquire further cytogenetic alterations other than Philadelphia chromosome.	16923567
Noncommunicable Diseases, infectious - Entity Risk, Fever	Stem Cell Exhaustion	The serum IL-12:IL-6 ratio reliably distinguishes infectious from non-infectious causes of fever during autologous stem cell transplantation.	16923608
Lymphoma, Non-Hodgkin, Hemopoietic stem cell transplant	Stem Cell Exhaustion	A 53-year-old female with non-Hodgkin's lymphoma received peripheral blood hematopoietic stem cell transplant from her HLA-matched sibling.	16924649
B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1	Stem Cell Exhaustion	Successful treatment of minimal residual disease-positive Philadelphia chromosome-positive acute lymphoblastic leukemia with imatinib followed by reduced-intensity unrelated cord blood transplantation after allogeneic peripheral blood stem cell transplantation.	16926141
B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1, BCR gene	Stem Cell Exhaustion	We describe a 35-year-old woman with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) who received allogeneic sibling donor peripheral blood stem cell transplantation (PBSCT) and entered a second complete remission.	16926141
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Feasibility and efficacy of high-dose melphalan, cyclophosphamide, etoposide, and dexamethasone (LEED) chemotherapy with or without rituximab followed by autologous stem cell transplantation for aggressive and relapsed non-Hodgkin's lymphoma.	16926142
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	To investigate the feasibility and efficacy of high-dose chemotherapy (HDCT) followed by autologous stem cell transplantation (ASCT) for patients with newly diagnosed aggressive and relapsed non-Hodgkin's lymphoma (NHL), we administered LEED, a drug-only HDCT regimen consisting of melphalan, cyclophosphamide, etoposide, and dexamethasone, followed by ASCT in this single-institution trial.	16926142
Coronary heart disease	Stem Cell Exhaustion	Circulating endothelial progenitor cells correlate with erectile function in patients with coronary heart disease.	16926179
Erectile dysfunction	Stem Cell Exhaustion	The aim of the study was to determine the influence of endothelial progenitor cells (EPC) on erectile dysfunction (ED).	16926179
Amyloidosis	Stem Cell Exhaustion	Successful treatment of AL amyloidosis with high-dose melphalan and autologous stem cell transplantation in patients over age 65.	16926284
Amyloidosis	Stem Cell Exhaustion	Recently, protocols using high-dose melphalan chemotherapy and autologous peripheral blood stem cell transplantation (HDM/SCT) have been developed for the treatment of patients with immunoglobulin light chain (AL) amyloidosis.	16926284
Kidney Failure, Chronic, Mesangiolysis	Stem Cell Exhaustion	Chronic renal failure with severe mesangiolysis in a hematopoietic stem cell transplant recipient.	16928623
Kidney Failure	Stem Cell Exhaustion	Chronic progressive renal failure is a well-recognized complication in hematopoietic stem cell transplantation (HSCT) recipients.	16928623
Multiple Myeloma	Stem Cell Exhaustion	Pegfilgrastim compared with filgrastim after high-dose melphalan and autologous hematopoietic peripheral blood stem cell transplantation in multiple myeloma patients.	16930141
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We undertook a comparative study of Pegfilgrastim vs. Filgrastim after high-dose melphalan and autologous peripheral blood stem cell transplantation (APBSCT) in multiple myeloma (MM) patients.	16930141
EBV-Related Sarcoma, Ulcer	Stem Cell Exhaustion	Epstein-Barr virus-associated enteritis with multiple ulcers after stem cell transplantation: first histologically confirmed case.	16930333
Multiple Myeloma	Stem Cell Exhaustion	A 57-year-old man had undergone a reduced intensity allogeneic stem cell transplantation for a relapse of multiple myeloma following sequential autologous peripheral blood stem cell transplantation.	16930333
Malignant tumor of colon, Lymphoma, leukemia	Stem Cell Exhaustion	The number of EBER-1-positive cells in the ileum (mucosa, 1451 cells/mm(2); submucosa, 465 cells/mm(2)) was much larger than in control samples (malignant lymphoma or leukemia after allogeneic stem cell transplantation, n = 4, range 0-113 cells/mm(2); malignant lymphoma after chemotherapy, n = 14, range 0-0.89 cells/mm(2); colon cancer, n = 12, range 0-3.5 cells/mm(2)).	16930333
Lymphoproliferative Disorders, Thrombotic Microangiopathies, Ulcer, EBV-Related Sarcoma	Stem Cell Exhaustion	The histological findings differ from post-transplant lymphoproliferative disorders or intestinal thrombotic microangiopathy, and this is the first case of EBV-associated enteritis with ulcers characterized by numerous plasma cells and lymphoepithelial-like lesions after stem cell transplantation.	16930333
Hematologic Neoplasms, Toxic effect	Stem Cell Exhaustion	In this study, we have investigated infusion-related toxicity regarding temperature of cryopreserved autologous peripheral blood progenitor cells (PBPCs) transplanted in 31 and allogeneic non-cryopreserved PBPCs in 4 patients receiving high dose chemotherapy and stem cells transplantation for hematological malignancies.	16931400
Cardiac Arrhythmia	Stem Cell Exhaustion	The effect of hematopoietic progenitor cells' temperature on cardiac arrhythmias in patients given peripheral blood progenitor cells.	16931400
Secondary Myelodysplastic Syndrome, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Main findings are as follows: (1) 5.5-years overall survival projection of 80% (median follow-up: 68 months), with no differences related to age-adjusted IPI score; (2) 46 (50%) of 92 patients presently in continuous complete remission; (3) projected long-term progression-free survival exceeding 80% for patients collecting PCR-negative stem cell harvests or achieving molecular remission within the first 2 years from the end of therapy; (4) actuarial 5-years risk of developing secondary myelodysplasia and acute myeloid leukemia of 3.7%, with most of these events occurring in patients re-treated for recurrent lymphoma.	16932351
Aplastic Anemia	Stem Cell Exhaustion	A 40-year-old woman with severe aplastic anemia and immune refractory to unselected PLT transfusions was transferred to a distant medical center for a hematopoietic peripheral blood progenitor cell transplant where she continued to receive HLA-matched PLTs from her dedicated donors.	16934064
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Efficacy of single-dose pegfilgrastim after chemotherapy for the mobilization of autologous peripheral blood stem cells in patients with malignant lymphoma or multiple myeloma.	16934080
Chronic heart failure	Stem Cell Exhaustion	Rapid succession of peripheral blood progenitor cell mobilization cycles in patients with chronic heart failure: effects on the hematopoietic system.	16934081
Coronary Arteriosclerosis	Stem Cell Exhaustion	The purpose of this study was to determine whether treatment with granulocyte colony-stimulating factor (G-CSF), which mobilizes endothelial progenitor cells from bone marrow, can safely improve the clinical outcomes of patients with atherosclerotic peripheral artery disease (PAD).	16936417
Polymyositis, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Polymyositis complicating donor lymphocyte infusion after stem cell transplantation for relapsed chronic myeloid leukemia: report of a case and review of literature.	16937070
Graft-vs-Host Disease, Tumor necrosis	Stem Cell Exhaustion	Recombinant human soluble tumor necrosis factor receptor fusion protein as treatment for steroid refractory graft-versus-host disease following allogeneic hematopoietic stem cell transplantation.	16937391
Cervical Intraepithelial Neoplasia	Stem Cell Exhaustion	These data suggest that increased local production of TGFbeta1 probably affects the BM megakaryocytic progenitor cell growth in CIN whereas the compensatory production of TPO finally balances the TGFbeta1-induced inhibitory effect.	16938119
Cervical Intraepithelial Neoplasia	Stem Cell Exhaustion	CIN patients (n = 39) showed a low proportion of BM CD34(+)/CD61(+) megakaryocytic progenitor cells and low frequency of early and mixed CFU-Meg in the BM mononuclear, but not CD34(+), cell fraction, compared with healthy controls (n = 20).	16938119
Up	Stem Cell Exhaustion	The current results indicate a significant reduction of progenitor cells (as labeled by Musashi1) in the SVZ of patients with AD, but an increase in GFAP-negative astrocyte-like cells with progenitor characteristics.	16938507
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Outcomes of alemtuzumab-based reduced intensity conditioning stem cell transplantation using unrelated donors for myelodysplastic syndromes.	16939494
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	These results suggest that in CML, BCR/ABL expression is associated with an increased proliferation of CD34+ myeloid haematopoietic progenitor cells but not of other more mature myeloid precursors, as confirmed by the observation of an inverse correlation between the amount of BCR/ABL transcripts and the proportion of S + G2/M-phase cells.	16939497
leukemia	Stem Cell Exhaustion	Natural killer (NK) cells play an important role in tumor-cell clearance, particularly against leukemia, as shown by killer cell inhibitory receptor (KIR)-mismatched allogeneic stem cell transplantation.	16940427
Nephrotic Syndrome	Stem Cell Exhaustion	Minimal-change nephrotic syndrome in a hematopoietic stem-cell transplant recipient.	16941046
Diphtheria, Tetanus, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 61-year-old woman received standard immunizations, including Haemophilus influenzae type B, diphtheria, tetanus toxoid, and unconjugated 23-valent pneumococcal vaccine (Pneumovax), Merck & Co., Inc., Whitehouse Station, NJ), 1 year after undergoing nonmyeloablative hematopoietic stem-cell transplantation for acute myelogenous leukemia.	16941046
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	We wondered whether the prognostic impact of the expression profile would hold out in a homogeneous cohort of poor-risk DLBCL patients treated with high-dose sequential therapy (HDT) and autologous stem-cell transplantation (ASCT) as first-line therapy.	16943530
Angiomyofibroblastoma	Stem Cell Exhaustion	These histological findings are consistent with angiomyofibroblastoma and support the hypothesis that angiomyofibroblastoma originates from perivascular stem cells with a capacity for myofibroblastic and fatty differentiation.	16943862
Specialty Type - cancer	Stem Cell Exhaustion	Four pediatric inpatient groups (177 patients): group 1 (107), those receiving cancer chemotherapy; group 2 (24), those receiving cancer chemotherapy before hematopoietic stem cell transplantation; group 3 (23), those with cancer who were not receiving cancer chemotherapy; and group 4 (23), those without cancer.	16945043
Myelokathexis	Stem Cell Exhaustion	WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus-truncated CXCR4.	16946301
Extrapulmonary Small Cell Carcinoma, Squamous cell carcinoma of esophagus	Stem Cell Exhaustion	In this study, we investigated the clinicopathologic significance of the low-affinity p75 neurotrophin receptor (p75NTR; which is expressed in the stem/progenitor cell fraction of normal esophageal epithelial cells) in 187 resected esophageal squamous cell carcinoma (ESCC) specimens and found that approximately 50% of ESCC expressed p75NTR.	16951226
Disease of capillaries, Kidney Failure	Stem Cell Exhaustion	Transplantation-associated microangiopathy (TAM) or renal insufficiency (RI) after allogeneic hematopoietic stem cell transplantation is associated with a high mortality.	16951692
Short Bowel Syndrome, Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	The patients included 7 transplant recipients (liver, hematopoietic stem cell), 3 with type 2 diabetes and a child on chronic parenteral nutrition for short bowel syndrome.	16952540
Infection, Multiple Myeloma	Stem Cell Exhaustion	MBL2 polymorphism and risk of severe infections in multiple myeloma patients receiving high-dose melphalan and autologous stem cell transplantation.	16953214
Herpes	Stem Cell Exhaustion	The aim of this study was to investigate the clinical impact of reactivation of human herpes virus-6 (HHV-6) and HHV-7 infections in stem cell transplantation recipients, and to examine a possible increase in virulence of the two roseoloviruses when a reactivation of CMV (HHV-5) simultaneously occurs.	16956672
Cytomegalovirus Infections, Herpesvirus 7, Human	Stem Cell Exhaustion	For this purpose, quantitative real-time PCR systems were developed to assess the viral load of CMV, HHV-6, or HHV-7 in the plasma of haematopoetic stem cell recipients.	16956672
Cytomegalovirus Infections, Herpesvirus 7, Human	Stem Cell Exhaustion	One hundred and ninety-eight plasma samples from 37 patients who underwent allogeneic stem cell transplantation were tested for CMV, HHV-6, and HHV-7 by a 5'-exonuclease (TaqMan) quantitative real-time PCR.	16956672
Zygomycosis, Aplastic Anemia	Stem Cell Exhaustion	Rhinocerebral zygomycosis in a young girl undergoing allogeneic stem cell transplantation for severe aplastic anaemia.	16961580
Mycoses	Stem Cell Exhaustion	Subsequently, the girl underwent allogeneic haematopoietic stem cell transplantation (HSCT) for the underlying disease, but the fungal infection remained under control with the antifungal treatment.	16961580
Chronic disseminated candidiasis, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Salvage therapy of refractory chronic disseminated candidiasis in a patient with acute myeloid leukaemia and secondary prophylaxis during allogeneic stem cell transplantation.	16961582
Malignant Lesion	Stem Cell Exhaustion	KIT/stem cell factor expression in premalignant and malignant lesions of the colon mucosa in relationship to disease progression and outcomes.	16964380
Premalignant Lesion, Stem Cell Factor, Cytogenetic Complete Response	Stem Cell Exhaustion	We investigated the expression of KIT and stem cell factor (SCF) in CRC in comparison with premalignant colon lesions and normal colonic mucosa to assess the prognostic and therapeutic relevance of this receptor/ligand system in CRC.	16964380
Malignant Neoplasms	Stem Cell Exhaustion	Morbidity and transplant-related mortality of CBV and BEAM preparative regimens for patients with lymphoid malignancies undergoing autologous stem-cell transplantation.	16966258
Lymphoma	Stem Cell Exhaustion	CBV and BEAM are the two most frequently used regimens for patients with lymphoma undergoing autologous hematopoietic stem-cell transplantation (ASCT).	16966258
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Marrow irradiation with high-dose 153Samarium-EDTMP followed by chemotherapy and hematopoietic stem cell infusion for acute myelogenous leukemia.	16966270
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In four patients, aged 15 - 20 years, with high-risk acute myeloid leukemia (AML), high-dose samarium 153-labelled ethylenediaminetetramethylenephosphonate (153Sm-EDTMP) was used for targeted marrow irradiation before preparative chemotherapy conditioning regimens and allogeneic (three patients) or autologous (one patient) hematopoietic stem cell transplantation.	16966270
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Feasibility of autologous peripheral blood stem cell transplantation in elderly patients with acute myeloid leukemia.	16966271
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Most studies showing that autologous stem cell transplantation (ASCT) is feasible in older patients with acute myeloid leukemia (AML) referred to highly selected patients considered as eligible after complete remission (CR) achievement and bone marrow or peripheral blood stem cell (PBSC) collection.	16966271
Amyloidosis	Stem Cell Exhaustion	[A case of systemic amyloidosis treated by chemotherapy with autologous peripheral blood stem cell transplantation].	16972617
Hematologic Neoplasms, Viral respiratory infection	Stem Cell Exhaustion	Respiratory viral infections in adults with hematologic malignancies and human stem cell transplantation recipients: a retrospective study at a major cancer center.	16974212
Cessation of life, Hematologic Neoplasms, Pneumonia	Stem Cell Exhaustion	Community respiratory viruses (CRVs) have been recognized as a potential cause of pneumonia and death among hematopoietic stem cell transplantation (HSCT) recipients and patients with hematologic malignancies.	16974212
Malignant neoplasm of prostate	Stem Cell Exhaustion	Prostate stem cell antigen (PSCA) and prostate-specific antigen (PSA) are overexpressed in most prostate cancers.	16977630
Neoplasms	Stem Cell Exhaustion	The occurrence of at least 4 distinct directions of mesenchymal cell differentiation within a benign neoplasia underlines the concept of multilineage differentiation of pluripotent mesenchymal stem cells.	16979520
Pulmonary Infiltrate	Stem Cell Exhaustion	Fiberoptic bronchoscopy with bronchoalveolar lavage (BAL) is thought to be the procedure of choice to evaluate pulmonary infiltrates in hematopoietic stem cell transplant (HSCT) recipients.	16980989
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	A reduced-intensity conditioning allogeneic stem cell transplantation was given to 19 patients (aged 15-59 years) in the first chronic phase and one patient in the accelerated phase with chronic myeloid leukemia (CML) after a regimen consisting of fludarabine (Flu), busulfan (Bu) and ATG Fresenius.	16980996
Gastrointestinal mucositis, Multiple Myeloma	Stem Cell Exhaustion	Oral mucositis in myeloma patients undergoing melphalan-based autologous stem cell transplantation: incidence, risk factors and a severity predictive model.	16980998
Stomatitis, Multiple Myeloma	Stem Cell Exhaustion	Melphalan-based autologous stem cell transplant (Mel-ASCT) is a standard therapy for multiple myeloma, but is associated with severe oral mucositis (OM).	16980998
Neoplasms	Stem Cell Exhaustion	Finally, we obtained cells from the tumor developing after grafting that clearly expressed the putative neural stem cell marker CD133 as shown by FACS analysis and also nestin and CXCR4.	16981197
Sepsis	Stem Cell Exhaustion	Kinetics of progenitor hemopoetic stem cells in sepsis: correlation with patients survival?	16981997
Sepsis	Stem Cell Exhaustion	Since monocytes derive from progenitor hemopoetic cells, the kinetics of stem cells was studied in peripheral blood of patients with sepsis.	16981997
Multiple Myeloma	Stem Cell Exhaustion	Sustained G-CSF plasma levels following administration of pegfilgrastim fasten neutrophil reconstitution after high-dose chemotherapy and autologous blood stem cell transplantation in patients with multiple myeloma.	16982322
Neutropenia	Stem Cell Exhaustion	Pegfilgrastim has shown to decrease the duration of severe neutropenia after conventional chemotherapy, but its use after high-dose chemotherapy and autologous blood stem cell transplantation has not been established yet.	16982322
Acute myocardial infarction	Stem Cell Exhaustion	Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction.	16990384
Acute myocardial infarction	Stem Cell Exhaustion	Pilot trials suggest that the intracoronary administration of autologous progenitor cells may improve left ventricular function after acute myocardial infarction.	16990384
Acute myocardial infarction, Infarction	Stem Cell Exhaustion	In a multicenter trial, we randomly assigned 204 patients with acute myocardial infarction to receive an intracoronary infusion of progenitor cells derived from bone marrow (BMC) or placebo medium into the infarct artery 3 to 7 days after successful reperfusion therapy.	16990384
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Transcoronary transplantation of progenitor cells after myocardial infarction.	16990385
Acute myocardial infarction	Stem Cell Exhaustion	Pilot studies suggest that intracoronary transplantation of progenitor cells derived from bone marrow (BMC) or circulating blood (CPC) may improve left ventricular function after acute myocardial infarction.	16990385
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Intracoronary infusion of progenitor cells is safe and feasible in patients with healed myocardial infarction.	16990385
Amyloidosis	Stem Cell Exhaustion	High-dose melphalan with stem-cell transplantation is believed to be the most effective treatment for systemic light-chain (AL) amyloidosis, but many patients are ineligible because of the extent of their disease, and treatment-related mortality (TRM) remains substantial.	16990593
Hypertrophy	Stem Cell Exhaustion	Suppression of genes related to hypertrophy and osteogenesis in committed human mesenchymal stem cells cultured on novel nitrogen-rich plasma polymer coatings.	16995797
Hypertrophy, Endochondral Ossification	Stem Cell Exhaustion	However, recent evidence indicates that a major drawback of current cartilage- and intervertebral disc-tissue engineering is that human MSCs isolated from some arthritic patients (a clinically relevant source of stem cells) express type X collagen (a marker of chondrocyte hypertrophy associated with endochondral ossification) and osteogenic markers.	16995797
Multiple Myeloma	Stem Cell Exhaustion	Multiple myeloma patients with CKS1B gene amplification have a shorter progression-free survival post-autologous stem cell transplantation.	16995883
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The prevalence and prognostic relevance of recurrent gains of CKS1B (cyclin kinase subunit 1B) gene at chromosome 1q21 region was investigated by interphase fluorescence in situ hybridisation in a cohort of 99 multiple myeloma (MM) patients treated with intensive chemotherapy followed by autologous stem cell transplantation.	16995883
Gastrointestinal mucositis, Malignant Neoplasms	Stem Cell Exhaustion	Severe mucositis is associated with reduced survival after autologous stem cell transplantation for lymphoid malignancies.	16995885
Gastrointestinal mucositis	Stem Cell Exhaustion	Mucositis is a known complication of autologous stem cell transplantation (ASCT).	16995885
Cryptozoospermia	Stem Cell Exhaustion	Cryptozoospermia with normal testicular function after allogeneic stem cell transplantation: a case report.	17000649
Gonadotropin deficiency	Stem Cell Exhaustion	One of the most frequent consequences of allogeneic haemopoietic stem cell transplantation (allo-SCT) in both males and females is gonadal insufficiency.	17000649
MYELODYSPLASTIC SYNDROME, Azoospermia	Stem Cell Exhaustion	We report the case of a 27-year-old myelodysplastic male who developed azoospermia after allogeneic transplantation of haemopoietic stem cells from his HLA-identical sister.	17000649
Hematologic Neoplasms	Stem Cell Exhaustion	Case-control comparison of at-home to total hospital care for autologous stem-cell transplantation for hematologic malignancies.	17001069
Tissue injury	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) have been identified among hematopoietic tissue-derived progenitor cells that are mobilized into the peripheral blood (PB) as a result of tissue injury.	17002637
Lymphoma	Stem Cell Exhaustion	Clinical data on patients with recurring lymphoma who were treated with second-line chemotherapy (DHAP-VIM-DHAP) followed by autologous stem cell transplantation (ASCT) were collected and combined with the results of FDG-PET performed before and after 2 cycles of reinduction chemotherapy.	17003382
Liver carcinoma	Stem Cell Exhaustion	Significance of circulating endothelial progenitor cells in hepatocellular carcinoma.	17006919
Liver carcinoma, Hollings Cancer Center, Neoplasms	Stem Cell Exhaustion	This study evaluated the significance of circulating bone marrow-derived endothelial progenitor cells (EPCs) in patients with hepatocellular carcinoma (HCC), a solid tumor with rich neovasculature.	17006919
Hypertrophy, Vascular Invasion Assessment, Calcinosis	Stem Cell Exhaustion	Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice.	17009260
Social security number, Interferon-alpha2b	Stem Cell Exhaustion	Topical IFN-alpha2b is an important treatment modality for recalcitrant OSSN; it avoids the risks of further limbal stem cell destruction from other agents and surgical excision.	17011846
Schizophrenia	Stem Cell Exhaustion	Given the role of QKI in determination of oligodendrocyte fate, these results not only confirm oligodendrocyte-related gene expression abnormalities in schizophrenia but suggest that the physiology of glial progenitor cells may be altered in schizophrenia.	17012699
Peripheral Blood Stem Cells	Stem Cell Exhaustion	After wide excision and high-dose chemotherapy with peripheral blood stem cell transfusion, the patient has been well and continuously event-free for 3 years since the initial diagnosis.	17016721
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Three single nucleotide polymorphisms (SNP) in the NOD2/CARD15 gene have been associated with the incidence and the severity of acute graft-versus-host disease (GVHD) following allogeneic stem cell transplantation (SCT).	17018387
Primary Myelofibrosis	Stem Cell Exhaustion	Monitoring of the JAK2-V617F mutation by highly sensitive quantitative real-time PCR after allogeneic stem cell transplantation in patients with myelofibrosis.	17018857
Primary Myelofibrosis	Stem Cell Exhaustion	The JAK2-V617F mutation occurs in about 50% of patients with myelofibrosis and might be a reliable marker to monitor residual disease after allogeneic stem cell transplantation.	17018857
Primary Myelofibrosis	Stem Cell Exhaustion	After 22 allogeneic stem cell transplantation procedures in 21 JAK2-positive patients with myelofibrosis, 78% became PCR negative.	17018857
Primary Myelofibrosis	Stem Cell Exhaustion	In conclusion, allogeneic stem cell transplantation after dose-reduced conditioning induces high rates of molecular remission in JAK2-positive patients with myelofibrosis, and quantification of V617F-JAK2 mutation by real-time PCR allows the detection of minimal residual disease to guide adoptive immunotherapy.	17018857
B-Cell Lymphomas	Stem Cell Exhaustion	De novo CD5+ diffuse large B cell lymphoma with basophilia in the peripheral blood: successful treatment with autologous peripheral blood stem cell transplantation.	17019691
Gastric Antral Vascular Ectasia	Stem Cell Exhaustion	Gastric antral vascular ectasia following hematopoietic stem cell transplantation was diagnosed by endoscopy, with histological confirmation.	17019760
Acute gastrointestinal hemorrhage, Angiectasis	Stem Cell Exhaustion	In conclusion, vascular ectasia of the whole intestine should be considered as cause of acute gastrointestinal bleeding after stem cell transplantation.	17019760
Multiple Myeloma	Stem Cell Exhaustion	Prognostic and biological implications of genetic abnormalities in multiple myeloma undergoing autologous stem cell transplantation: t(4;14) is the most relevant adverse prognostic factor, whereas RB deletion as a unique abnormality is not associated with adverse prognosis.	17024116
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Immunotherapy with rituximab/interleukin-2 after autologous stem cell transplantation as treatment for CD20+ non-Hodgkin's lymphoma.	17026825
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Relapse of non-Hodgkin's lymphoma (NHL) remains a problem after autologous stem cell transplantation (ASCT).	17026825
Ischemia	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPC) localise to sites of ischaemia and play a role in vascular repair and re-endothelialisation of injured blood vessels.	17027849
Hematologic Neoplasms	Stem Cell Exhaustion	Umbilical cord blood transplant (UCBT) has emerged as an alternate source of stem cells for transplantation in patients with hematologic malignancies.	17028624
Anaplastic carcinoma	Stem Cell Exhaustion	These data strongly suggest that in anaplastic carcinomas, impairment of p53-mediated repression results in increased GLUT1 and p63 expression, and that this probably reflects the differential regulation of hypoxia-responsive pathways and basal/stem cell regulatory pathways.	17029809
herpesvirus 3, human	Stem Cell Exhaustion	Relationship between preexisting anti-varicella-zoster virus (VZV) antibody and clinical VZV reactivation in hematopoietic stem cell transplantation recipients.	17035500
Herpes zoster disease, herpesvirus 3, human, Communicable Diseases	Stem Cell Exhaustion	Reactivation of latent varicella-zoster virus (VZV), presenting as localized zoster or as disseminated infection, is a common and potentially serious complication in hematopoietic stem cell transplantation (HSCT) recipients.	17035500
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Myeloablative chemotherapy followed by autologous stem cell infusion may overcome the adverse prognostic impact of FLT3 (foetal liver tyrosine kinase 3) mutations in patients with acute myeloid leukaemia and normal karyotype.	17036374
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In this study, we analysed the prognostic relevance of foetal liver tyrosine kinase 3 (FLT3) mutations in 73 patients with acute myeloid leukaemia (AML) with normal karyotype, who survived induction and consolidation and received autologous stem cell transplantation (ASCT) after successful mobilization of peripheral blood stem cell (PBSC).	17036374
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Prospective feasibility analysis of reduced-intensity conditioning (RIC) regimens for hematopoietic stem cell transplantation (HSCT) in elderly patients with acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS).	17038533
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	To prospectively assess the applicability of reduced-intensity conditioning hematopoietic stem cell transplantation (RIC-HSCT), we wrote a protocol in which all untreated patients 50 years or older with acute myeloid leukemia (AML) and unfavorable cytogenetics would be evaluated during induction for a possible RIC-HSCT in first complete remission (CR1).	17038533
Neoplasms	Stem Cell Exhaustion	The morphologic findings and these results strengthen the hypothesis that these tumors may share a common progenitor cell, which has also been observed by others.	17039400
beta Thalassemia	Stem Cell Exhaustion	Infusion of autologous retrodifferentiated stem cells into patients with beta-thalassemia.	17041717
beta Thalassemia	Stem Cell Exhaustion	Herein, the outcome of infusion of autologous retrodifferentiated stem cells (RSC) into 21 patients with beta-thalassemia is described.	17041717
Multiple Myeloma	Stem Cell Exhaustion	Effect of CD34 cell dose on hematopoietic reconstitution and outcome in 508 patients with multiple myeloma undergoing autologous peripheral blood stem cell transplantation.	17042762
T-Cell Lymphoma, Central Nervous System, Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	A 43-year-old female with large T-cell non-Hodgkin's lymphoma and central nervous system (CNS) involvement underwent HLA-identical-sibling peripheral blood stem cell transplantation (SCT) during her third complete remission.	17042768
Anemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	An antecedent diagnosis of refractory anemia with excess blasts has no influence on mobilization of peripheral blood stem cells and hematopoietic recovery after autologous stem cell transplantation in acute myeloid leukemia.	17042770
Anemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	On the contrary, data from patients with acute myeloid leukemia (AML) are very limited, in particular, as the impact of an antecedent diagnosis of refractory anemia with excess blasts (RAEB) on mobilization of PBSCs as well as hematopoietic recovery after autologous stem cell transplantation (ASCT) is concerned.	17042770
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We retrospectively analyzed a cohort of 150 consecutive AML patients in first complete remission in order to make a comparison between patients with de novo AML and secondary AML (s-AML) in terms of CD34 positive (CD34+) cells mobilization and number of leukapheresis needed to collect at least one single stem cell graft.	17042770
Multiple Myeloma	Stem Cell Exhaustion	Bortezomib plus dexamethasone as induction treatment prior to autologous stem cell transplantation in patients with newly diagnosed multiple myeloma: results of an IFM phase II study.	17043025
Multiple Myeloma	Stem Cell Exhaustion	Induction regimens prior to autologous stem cell transplantation (ASCT) in newly diagnosed multiple myeloma patients usually result in complete remission (CR) rates of <10%.	17043025
Pancreatic carcinoma	Stem Cell Exhaustion	The stem cell factor/c-kit receptor pathway enhances proliferation and invasion of pancreatic cancer cells.	17044945
Neoplasms	Stem Cell Exhaustion	Using stem cell medium, we cultured a few tumors.	17047046
Hypersensitivity	Stem Cell Exhaustion	Many hypotheses as stem-cell depletion in the radiotherapy field, heritable mutations within surviving stem cells, local vascular changes as well as a drug hypersensitivity reaction have been proposed to explain these reactions.	17049669
PAFAH1B1 wt Allele	Stem Cell Exhaustion	These findings indicate that in some cases of otherwise typical MDS, the progenitor cells may have some capacity for monocytic proliferation at diagnosis and manifest rapid disease progression once a monocytic proliferation supervenes.	17050076
Febrile Neutropenia, White blood cell count decreased	Stem Cell Exhaustion	Correlation of residual leukocyte subsets with neutropenic fever during severe leukopenia after high-dose chemotherapy and autologous stem cell transplantation.	17050252
Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy with autologous stem cell transplantation is the standard treatment of eligible patients with multiple myeloma.	17050252
Multiple Myeloma	Stem Cell Exhaustion	Residual leukocyte subsets in the peripheral blood on days 4-7 following autologous stem cell transplantation were analyzed by three-color flow cytometry in 20 patients with multiple myeloma.	17050252
Febrile Neutropenia	Stem Cell Exhaustion	Low absolute lymphocyte counts and absolute CD4+ T-cell counts on days 4-7 after stem cell transplantation correlated with neutropenic fever.	17050252
Febrile Neutropenia	Stem Cell Exhaustion	Furthermore, T-cell numbers in the autologous stem cell grafts that the patients received were significantly lower in patients with neutropenic fever.	17050252
Venoocclusive disease	Stem Cell Exhaustion	No veno-occlusive disease occurred after GO or after hematopoietic stem cell transplantation given after GO in seven patients.	17051246
BONE MARROW FAILURE SYNDROME 1, Aplastic Anemia	Stem Cell Exhaustion	Aplastic anemia (AA) is a bone marrow failure syndrome mostly characterized by an immune-mediated destruction of marrow hematopoietic progenitor/stem cells.	17052335
Infection of bloodstream	Stem Cell Exhaustion	Vancomycin-resistant enterococcal bloodstream infections on a hematopoietic stem cell transplant unit: are the sick getting sicker?	17057724
Hematologic Neoplasms, Behavioral Symptoms Index Composite Score (BASC-2), Infection of bloodstream	Stem Cell Exhaustion	Patients with hematologic malignancies and hematopoietic stem cell transplant (HSCT) recipients are at high risk for bacterial bloodstream infections (BSI) owing to resistant organisms.	17057724
Hematopoietic stem cells, Aplastic Anemia, Liver Failure, Acute	Stem Cell Exhaustion	The majority of authors mention aplastic anaemia as a secondary event post liver transplant, whereas in our view this might be a haematopoietic stem cell disorder preceding fulminant hepatic failure.	17058230
Fanconi Anemia	Stem Cell Exhaustion	A 28-year-old woman underwent peripheral-blood stem cell transplantation from her HLA-identical sister for cytogenetic progression of Fanconi anemia.	17060002
Kidney Failure, Acute	Stem Cell Exhaustion	Nine days after peripheral-blood stem cell transplantation, she developed acute renal failure secondary to acute rejection.	17060002
Cytomegalovirus Infections	Stem Cell Exhaustion	A recent study reported that quantitation of cytomegalovirus (CMV)-specific CD8+ T lymphocytes in the graft and monitoring of these T cells might identify hematopoietic stem cell transplantation-recipients at the risk for progressive CMV infection.	17063516
Hepatitis B	Stem Cell Exhaustion	Lamivudine prophylaxis and treatment of hepatitis B Virus-exposed recipients receiving reduced intensity conditioning hematopoietic stem cell transplants with alemtuzumab.	17063522
Liver Cirrhosis	Stem Cell Exhaustion	[Hepatic progenitor cell activation and expansion in human liver cirrhosis].	17064468
Liver Cirrhosis	Stem Cell Exhaustion	Human hepatic progenitor cell activation exists in human liver cirrhosis.	17064468
Liver Cirrhosis, Hepatitis	Stem Cell Exhaustion	To confirm whether human hepatic progenitor cells (HPCs) occur in human liver cirrhosis, to investigate the relationship between the degree of HPCs activation and the degree of liver inflammation and to provide evidence that HPCs can differentiate into hepatocytes.	17064468
Supratentorial Embryonal Tumor, Not Otherwise Specified, Medulloblastoma	Stem Cell Exhaustion	High-dose chemotherapy and autologous stem cell rescue in children with newly diagnosed high-risk or relapsed medulloblastoma or supratentorial primitive neuroectodermal tumor.	17066462
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	High dose chemotherapy and autologous stem cell transplantation in non-Hodgkin's lymphoma: an eight-year experience.	17066504
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) is commonly used in relapsed or refractory non-Hodgkin's lymphoma (NHL).	17066504
Diffuse alveolar hemorrhage	Stem Cell Exhaustion	Diffuse alveolar hemorrhage and infection-associated alveolar hemorrhage following hematopoietic stem cell transplantation: related and high-risk clinical syndromes.	17067910
Diffuse alveolar hemorrhage, Pulmonary Complication	Stem Cell Exhaustion	Diffuse alveolar hemorrhage (DAH) is a noninfectious pulmonary complication of hematopoietic stem cell transplantation (HSCT) with unclear pathogenesis and treatment.	17067910
Hematologic Neoplasms, Primary Biliary Cholangitis	Stem Cell Exhaustion	Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation and primary biliary cirrhosis.	17068145
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	One exception has been a subgroup of patients with multiple myeloma (MM) who underwent allogeneic hematopoietic stem cell transplantation (HSCT) and received donor lymphocyte infusions (DLIs) after transplantation.	17068145
Celiac Disease	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation in refractory celiac disease with aberrant T cells.	17068146
Autoimmune Diseases	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation (ASCT) is an increasingly accepted treatment for refractory autoimmune diseases.	17068146
Congestive heart failure	Stem Cell Exhaustion	Circulating endothelial progenitor cells in congestive heart failure.	17070610
Multiple Myeloma	Stem Cell Exhaustion	High-dose melphalan versus busulfan, cyclophosphamide, and etoposide as preparative regimens for autologous stem cell transplantation in patients with multiple myeloma.	17070906
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy (HDC) with autologous stem cell transplant (ASCT) has improved response rates and survival for patients with multiple myeloma (MM).	17070906
Toxic effect	Stem Cell Exhaustion	BCV and HDM confer similar long-term outcomes with similar toxicity profiles as conditioning regimens prior to autologous stem cell transplant in patients with MM.	17070906
Lymphoma, Follicular	Stem Cell Exhaustion	Myeloablative radio-chemotherapy with subsequent autologous stem cell transplantation (ASCT) significantly prolongs progression free and probably overall survival in follicular lymphoma (FL) in first remission.	17071931
Lymphoma	Stem Cell Exhaustion	Initial chemotherapy with mitoxantrone, chlorambucil, prednisone impairs the collection of stem cells in patients with indolent lymphomas--results of a randomized comparison by the German Low-Grade Lymphoma Study Group.	17071931
Asthma, Malignant neoplasm of lung	Stem Cell Exhaustion	Lung specimens obtained at operation due for small size lung cancer in 16 asthmatic patients and 16 controls were evaluated immunohistochemically using antibodies of EG2 (eosinophil), AA1 (mast cell), CD68 (macrophage), and CD34 (pluripotent hematopoietic stem cell).	17075272
Angina Pectoris, Cardiac Arrhythmia	Stem Cell Exhaustion	No stem cell-related arrhythmias, deterioration of angina were noted.	17081355
Acute myocardial infarction	Stem Cell Exhaustion	[Endothelial progenitor cells related gene expression changes before and early after revascularization in patients with acute myocardial infarction].	17081366
Acute myocardial infarction	Stem Cell Exhaustion	The purpose of this study was to observe the endothelial progenitor cells (EPCs) related gene expression changes before and early after revascularization in patients with acute myocardial infarction.	17081366
Acute myocardial infarction	Stem Cell Exhaustion	PCI down-regulated endothelial progenitor cells related gene expressions in patients with acute myocardial infarction.	17081366
European Organization for Research and Treatment of Cancer	Stem Cell Exhaustion	The EORTC QLQ-HDC29: a supplementary module assessing the quality of life during and after high-dose chemotherapy and stem cell transplantation.	17081744
Primary Myelofibrosis	Stem Cell Exhaustion	Clonogenic stem cell assays confirmed differentiation towards both the hematopoietic and the endothelial cell lineage in 5/10 patients with CIMF.	17082007
Myeloproliferative disease	Stem Cell Exhaustion	Hematopoietic and endothelial progenitor cell trafficking in patients with myeloproliferative diseases.	17082007
Myeloproliferative disease	Stem Cell Exhaustion	The presence of circulating hematopoietic progenitor cells in patients with myeloproliferative diseases (MPD) has been described.	17082007
Primary Myelofibrosis	Stem Cell Exhaustion	A subset of patients with CIMF co-expressed the markers CD34, prominin (CD133) and KDR, suggesting the presence of endothelial precursors among the circulating progenitor cells.	17082007
Disease	Stem Cell Exhaustion	The outcome of autologous stem cell transplantation in patients with plasma cell disorders and dialysis-dependent renal failure.	17082013
Ischemic stroke, Cerebrovascular accident	Stem Cell Exhaustion	Granulocyte-colony-stimulating factor mobilizes bone marrow stem cells in patients with subacute ischemic stroke: the Stem cell Trial of recovery EnhanceMent after Stroke (STEMS) pilot randomized, controlled trial (ISRCTN 16784092).	17082474
Cerebrovascular accident	Stem Cell Exhaustion	We assessed the safety of granulocyte-colony-stimulating factor (G-CSF) after stroke and its effect on circulating CD34+ stem cells.	17082474
Ischemic stroke	Stem Cell Exhaustion	G-CSF is effective at mobilizing bone marrow CD34+ stem cells in patients with recent ischemic stroke.	17082474
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	A total of 10 lymphoma and myeloma patients, in remission following induction therapy and considered eligible for high-dose therapy and autologous stem cell transplantation, were included in the study.	17083110
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Predictors of improved progression-free survival after nonmyeloablative allogeneic stem cell transplantation for advanced chronic lymphocytic leukemia.	17084369
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	In this analysis, we report the outcomes of 46 patients with advanced CLL who underwent nonmyeloablative stem cell transplantation (NST) from HLA-matched unrelated (67%) or related (33%) donors.	17084369
Leprosy	Stem Cell Exhaustion	Seven days after completion of the placental umbilical cord blood transfusion, the peripheral blood hematopoietic stem cell (CD34) estimation revealed a rise from the pretransfusion base level (.09%), varying from 3.6% to 16.2%, in 75% of the cases, without provoking any clinical graft vs host reaction in any of the leprosy victims.	17089580
Anemia, Leprosy	Stem Cell Exhaustion	Transient spontaneous engraftment of CD34 hematopoietic cord blood stem cells as seen in peripheral blood: treatment of leprosy patients with anemia by placental umbilical cord whole blood transfusion.	17089580
Left ventricular ejection fraction	Stem Cell Exhaustion	PCI alone did not increase left ventricular ejection fraction (LVEF), but following stem cell therapy, the LVEF increased significantly from 26 +/- 6% at baseline to 37 +/- 9% at 3 months (p < 0.05).	17090821
Ischemic cardiomyopathy	Stem Cell Exhaustion	Intracoronary transplantation of autologous bone marrow mesenchymal stem cells for ischemic cardiomyopathy due to isolated chronic occluded left anterior descending artery.	17090821
Ischemic cardiomyopathy	Stem Cell Exhaustion	Studies have revealed that stem cells improve clinical outcomes in patients with severe ischemic cardiomyopathy, but the role of bone marrow mesenchymal stem cells is not well understood.	17090821
Cardiomyopathies	Stem Cell Exhaustion	Intracoronary transplantation of autologous bone marrow mesenchymal stem cells improved clinical outcomes in patients with chronic ischemic cardiomyopathy.	17090821
Multiple Myeloma	Stem Cell Exhaustion	No recurrence of the multiple myeloma was seen after an autologous peripheral blood stem cell transplantation.	17094578
Multiple Myeloma	Stem Cell Exhaustion	Phenotypic and functional characterization of bone marrow mesenchymal stem cells derived from patients with multiple myeloma.	17096013
Trichosporonosis, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Herein is presented an autopsy case of disseminated trichosporonosis caused by T. inkin in a 30-year-old man with allogenic peripheral blood stem cell transplantation for acute myelocytic leukemia.	17096731
Acute myocardial infarction	Stem Cell Exhaustion	Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: final 1-year results of the REPAIR-AMI trial.	17098754
Acute myocardial infarction	Stem Cell Exhaustion	To investigate the clinical outcome after intracoronary administration of autologous progenitor cells in patients with acute myocardial infarction (AMI).	17098754
Infarction	Stem Cell Exhaustion	Using a double-blind, placebo-controlled multicentre trial design, we randomized 204 patients with successfully reperfused AMI to receive intracoronary infusion of bone-marrow-derived progenitor cells (BMCs) or placebo medium into the infarct artery 3-7 days after successful infarct reperfusion therapy.	17098754
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	The non-relapse mortality of autologous stem cell transplant is low enough that the procedure has been extended to older patients with non-Hodgkin's lymphoma.	17100730
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	We treated 537 non-Hodgkin's lymphoma patients with high-dose chemotherapy consisting of busulfan, cyclophosphamide, and etoposide followed by autologous stem cell transplant.	17100730
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 48-yr-old man with acute myeloid leukemia (AML) required urgent allogeneic hematopoietic stem cell transplantation because of failed attempts to induce remission via chemotherapy.	17100972
Ocular surface disease	Stem Cell Exhaustion	We used AS from 10 patients with severe ocular surface disease and total limbal stem cell deficiency to develop autologous cultivated oral epithelial equivalents.	17102000
Carcinogenesis	Stem Cell Exhaustion	Notch, Wnt and Hedgehog (Hh) signalings are important for stem cell self-renewal and carcinogenesis in the gastrointestinal epithelium.	17102592
Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Rituximab added to an intensified salvage chemotherapy program followed by autologous stem cell transplantation improved the outcome in relapsed and refractory aggressive non-Hodgkin lymphoma.	17103169
Lymphoma, Non-Hodgkin, Familial, Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	We investigated the addition of rituximab to an intensified salvage program followed by a myeloablative course with autologous stem cell transplantation (ASCT) in patients with relapsed or refractory aggressive non-Hodgkin lymphoma (NHL).	17103169
Enlargement procedure, Extramedullary Hematopoiesis Function, Immature Myeloid Cell	Stem Cell Exhaustion	Proposed mechanisms accounting for splenic enlargement include extramedullary haemopoiesis, intrasplenic infiltration by mature and immature myeloid cells and intrasplenic stem cell homing and proliferation.	17105496
Multiple Myeloma	Stem Cell Exhaustion	A retrospective case-matched study was conducted to compare the oral regimen CTD (cyclophosphamide - thalidomide - dexamethasone) and infusional CVAMP (cyclophosphamide - vincristine - doxorubicin - methylprednisolone) as induction therapy followed by autologous peripheral blood stem-cell transplantation (PBSCT) for newly diagnosed multiple myeloma patients.	17107906
Lymphoma	Stem Cell Exhaustion	High-dose therapy and autologous stem-cell transplantation can improve event-free survival for indolent lymphoma: a study using patients as their own controls.	17111421
Lymphoma	Stem Cell Exhaustion	High-dose therapy (HDT) and autologous stem-cell transplantation (ASCT) remain controversial for indolent lymphoma patients.	17111421
Juvenile Myelomonocytic Leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Donor cell-derived acute myeloblastic leukemia after allogeneic peripheral blood hematopoietic stem cell transplantation for juvenile myelomonocytic leukemia.	17114967
Juvenile Myelomonocytic Leukemia, Hematopoietic stem cells, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We report here the case of a 5 year-old girl with juvenile myelomonocytic leukemia and normal female karyotype who developed acute myeloblastic leukemia with a karyotype of 46, X, t(X; 7) (p21; p11.2), der(7) t(3; 7) (q13.3; q22) 5 months after peripheral blood hematopoietic stem cell transplantation from her HLA-matched sister.	17114967
Hodgkin Disease	Stem Cell Exhaustion	LACE-conditioned autologous stem cell transplantation for relapsed or refractory Hodgkin's lymphoma: treatment outcome and risk factor analysis in 67 patients from a single centre.	17115062
Hodgkin Disease	Stem Cell Exhaustion	High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is a recognized treatment option for patients with relapsed Hodgkin's lymphoma.	17115062
Hematologic Neoplasms	Stem Cell Exhaustion	Allogeneic marrow stem-cell transplantation from human leukocyte antigen-identical siblings versus human leukocyte antigen-allelic-matched unrelated donors (10/10) in patients with standard-risk hematologic malignancy: a prospective study from the French Society of Bone Marrow Transplantation and Cell Therapy.	17116940
Hematologic Neoplasms	Stem Cell Exhaustion	To investigate the influence of donor type (human leukocyte antigen [HLA] -identical sibling donor versus HLA-A-, HLA-B-, HLA-Cw-, HLA-DRB1-, and HLA-DQB1-identical unrelated donors, or so-called 10/10) on the outcome of patients who underwent allogeneic stem-cell transplantation (alloSCT), adjusting for other prognostic factors, in patients with standard-risk hematologic malignancy.	17116940
Cytomegalovirus Infections	Stem Cell Exhaustion	Low levels of Cytomegalovirus (CMV) viral load are frequently detected following allogeneic stem cell transplantation (SCT) and CMV disease may still develop in some allogeneic SCT patients who have negative pp65-antigenemia (pp65-Ag) or undetectable DNA.	17118205
Autoimmune Diseases, Multiple Myeloma	Stem Cell Exhaustion	Recurrence of autoimmune disease after autologous peripheral blood stem cell transplantation for multiple myeloma.	17118763
Hematologic Neoplasms, Autoimmune Diseases	Stem Cell Exhaustion	There have been a number of reports on the improvement of concomitant autoimmune disease (AID) after autologous hematopoietic stem cell transplantation (SCT) performed for hematologic malignancy.	17118763
Multiple Myeloma	Stem Cell Exhaustion	Our experience suggests that autologous SCT with unmanipulated stem cells for myeloma is unlikely to cure preexisting AID; rather, the AID may worsen.	17118763
pulmonary toxicity	Stem Cell Exhaustion	To the authors knowledge, this is the first report of life-threatening pulmonary toxicity after bortezomib in a non-Japanese patient and without history of prior autologous peripheral stem cell transplant.	17122539
Neoplasms, Malignant tumor of colon, Specialty Type - cancer	Stem Cell Exhaustion	What has yet to be established is whether every colon cancer cell possesses the potential to initiate and sustain tumour growth, or whether the tumour is hierarchically organized so that only a subset of cells--cancer stem cells--possess such potential.	17122772
Neoplasms, Malignant tumor of colon, Specialty Type - cancer	Stem Cell Exhaustion	The identification of colon cancer stem cells that are distinct from the bulk tumour cells provides strong support for the hierarchical organization of human colon cancer, and their existence suggests that for therapeutic strategies to be effective, they must target the cancer stem cells.	17122772
Neoplasms, Astrocytoma	Stem Cell Exhaustion	To investigate further whether these properties of tumor stem cells are correlated with their biological behavior, immunohistochemistry was performed on brain sections from astrocytomas of different grades using antibodies against neural stem cell markers.	17127461
Neoplasms, Astrocytoma	Stem Cell Exhaustion	The number of cells expressing Ki67 antigen and neural stem cell markers was increased in relation to worsening histological grade of astrocytomas, indicating that the capacity for tumor stem cell proliferation may be clinically relevant.	17127461
Malignant Neoplasms, Neoplasms, Astrocytoma	Stem Cell Exhaustion	Proliferative status of tumor stem cells may be correlated with malignancy grade of human astrocytomas.	17127461
Neoplasms	Stem Cell Exhaustion	Tumor stem cells are implicated in tumor initiation and maintenance.	17127461
Neoplasms	Stem Cell Exhaustion	Recent studies have shown that a subpopulation of cells isolated from brain tumors can form neurospheres in vitro, and have multiple characteristic properties observed in neural stem cells.	17127461
Neoplasms	Stem Cell Exhaustion	In vivo implantation of these cells can induce tumors that phenocopy original tumors, suggesting that tumor stem cells are involved in brain carcinogenesis.	17127461
Glioblastoma	Stem Cell Exhaustion	We found that a population of cells in human glioblastoma multiforme expressed multiple protein markers of neural stem cells including nestin, TUC-4, doublecortin and beta III-tubulin.	17127461
Neoplasms, Astrocytoma, Carcinogenesis	Stem Cell Exhaustion	Thus, tumor stem cells in astrocytomas may be involved in carcinogenesis.	17127461
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	HLA-identical sibling allogeneic peripheral blood stem cell transplantation with reduced intensity conditioning compared to autologous peripheral blood stem cell transplantation for elderly patients with de novo acute myeloid leukemia.	17128198
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We conducted a retrospective registry-based analysis to compare the outcome of 361 allogeneic human leukocyte antigen (HLA)-identical peripheral blood stem cell transplants (PBSCT) with reduced intensity conditioning (RIC) to that of 1369 autologous (auto) PBSCT in patients aged 50 years or older with de novo acute myeloid leukemia (AML), performed from 1997 until 2003 and reported to the European Group for Blood and Marrow Transplantation.	17128198
Amyloidosis	Stem Cell Exhaustion	[White blood cell lysis syndrome after autologous peripheral blood stem cell transplantation in the treatment of renal AL amyloidosis.	17130952
Amyloidosis	Stem Cell Exhaustion	The treatment of AL amyloidosis was not successful until the advent of myeloablative chemotherapy consisting of high-dose intravenous melphalan followed by autologous peripheral blood stem cell transplantation.	17130952
Kidney Failure, Acute, Nephrotic Syndrome, Primary amyloidosis	Stem Cell Exhaustion	We report a 59 year-old female with a nephrotic syndrome due to primary amyloidosis successfully treated autologous stem cell transplantation who developed acute renal failure caused by white blood cell lysis syndrome.	17130952
Dysfibrinogenemia, Hodgkin Disease, Thrombosis	Stem Cell Exhaustion	Hematopoietic stem cell transplantation for Hodgkin's disease in a patient with dysfibrinogenemia and thrombosis.	17131175
Dysfibrinogenemia, Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	This is the first case report of a patient with dysfibrinogenemia undergoing peripheral blood stem cell transplantation.	17131175
Malignant Neoplasms	Stem Cell Exhaustion	Second solid cancers after allogeneic hematopoietic stem cell transplantation.	17131350
Malignant Neoplasms	Stem Cell Exhaustion	The objective of this study was to establish the incidence and risk factors for the development of second solid cancers after allogeneic hematopoietic stem cell transplantation (allo-HSCT).	17131350
leukemia	Stem Cell Exhaustion	The use of autologous cord blood is, however, often not the best choice for treating leukaemia in young children and the number of stem cells is often too low in a single-cord blood sample to treat older children and adults.	17131697
Peripheral Stem Cell Transplantation, Post-Traumatic Stress Disorder, Trauma, Multiple Myeloma	Stem Cell Exhaustion	A qualitative study of the trauma and posttraumatic growth of multiple myeloma patients treated with peripheral blood stem cell transplant.	17133896
Multiple Myeloma	Stem Cell Exhaustion	The study was conducted to understand the emotional impact of multiple myeloma, as well as the impact of its principle treatment, peripheral blood stem cell transplant (PBSCT).	17133896
Secondary Neoplasm	Stem Cell Exhaustion	The finding that only one overt axillary metastasis occurred during follow-up of patients who did not receive ALND (whereas eight cases were expected) could be explained by various hypotheses, including those from cancer-stem-cell research.	17138219
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease (GVHD) is a major limiting factor in allogeneic hematopoietic stem cell transplantation (HSCT), and the timing of acute GVHD may affect patient outcomes.	17138825
Neoplasms	Stem Cell Exhaustion	Again, label-retaining stem cells were found in all the three kinds of NPC xenograft tumors (approximately 0.3% of cells), around 16% of which were also labeled with radioactive thymidine.	17139514
Secondary Neoplasm	Stem Cell Exhaustion	More importantly, our data showed that NPC also contained stem cells, which are most likely the cause for NPC spread, metastasis and recurrence.	17139514
Leukoencephalopathy	Stem Cell Exhaustion	Progressive multifocal leukoencephalopathy in a haploidentical stem cell transplant recipient: a clinical, neuroradiological and virological response after treatment with risperidone.	17140673
Specialty Type - cancer, Degenerative disorder, Heart Diseases, Nerve Degeneration	Stem Cell Exhaustion	First, vitamin C is now known to be involved in several novel physiological phenomena including stem cell differentiation and respiratory development, which likely require pharmacological levels of vitamin C. Secondly, the growing recognition that many ageing-related diseases, including heart disease, neural degeneration and cancer, may have a contributing oxidative damage factor that might be reduced by dietary antioxidants such as vitamin C. In this paper, we hypothesize that high serum-level vitamin C provides important, broad-ranging therapeutic benefits in treating ageing-related degenerative diseases.	17141419
Amyloidosis	Stem Cell Exhaustion	Long-term results of a risk-adapted approach to melphalan conditioning in autologous peripheral blood stem cell transplantation for primary (AL) amyloidosis.	17145600
Primary amyloidosis	Stem Cell Exhaustion	High-dose melphalan with autologous peripheral blood stem cell transplantation (ASCT) is an effective treatment for systemic primary amyloidosis.	17145600
Malignant neoplasm of gastrointestinal tract	Stem Cell Exhaustion	Dysregulated expression of stem cell factor Bmi1 in precancerous lesions of the gastrointestinal tract.	17145814
Neoplasms, Acute leukemia	Stem Cell Exhaustion	In this report, the effects of the combined prophylaxis of oral cooling (cryotherapy) and administration of propantheline, an anticholinergic drug, were studied in patients (aged 2-16 year) with acute leukemias or solid tumors, who underwent myeloablative chemo-radiotherapy and autologous peripheral blood stem cell rescue from 1993 to 1997.	17146197
Pneumonia	Stem Cell Exhaustion	Decreasing mortality rate in early pneumonia following hematopoietic stem cell transplantation.	17148063
Pulmonary Complication	Stem Cell Exhaustion	Pulmonary complications after allogeneic hematopoietic stem-cell transplantation (HSCT) remain 1 of the most important causes of morbidity and mortality.	17148063
Renal Cell Carcinoma	Stem Cell Exhaustion	CD133+ cells were isolated from 30 human renal carcinomas and characterized as renal resident progenitor cells on the basis of the expression of renal embryonic and mesenchymal stem cell markers.	17148683
Renal Cell Carcinoma, Neoplasms	Stem Cell Exhaustion	In conclusion, these results indicate the presence of a renal progenitor cell population in renal carcinomas that may differentiate in endothelial cells and favor vascularization and tumor growth.	17148683
Neoplasms	Stem Cell Exhaustion	CD133+ renal progenitor cells contribute to tumor angiogenesis.	17148683
Neoplasms	Stem Cell Exhaustion	In the present study, we tested the hypothesis that resident progenitor cells may contribute to tumor vascularization and growth.	17148683
Acute myocardial infarction	Stem Cell Exhaustion	Stem cell therapy has been suggested to be beneficial in patients after acute myocardial infarction (AMI).	17152990
Malignant Neoplasms	Stem Cell Exhaustion	Seventeen of 20 patients with malignancy resumed chemotherapy after a median of 19 days from surgery, range 7-81, and 11 of them underwent hematopoietic stem cell transplantation after a median time of 60 days from surgery, range 19-110.	17154183
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Specific immunotherapies for patients with chronic myeloid leukemia (CML) might eliminate residual CML cells after therapy with imatinib or chemotherapy and might enhance a specific graft-versus-leukemia effect after allogeneic stem cell transplantation.	17157168
Graft-vs-Host Disease	Stem Cell Exhaustion	Donor cell reaction to OKT3 as predictor of chronic graft-vs-host disease in hematopoietic stem cell recipients.	17157173
Coronary Arteriosclerosis	Stem Cell Exhaustion	Angiogenic growth factors and stem cell therapies have demonstrated varying results in patients with chronic coronary artery disease.	17157396
Chronic myocardial ischemia	Stem Cell Exhaustion	Circulating angiogenic cytokines and stem cells in patients with severe chronic ischemic heart disease--indicators of myocardial ischemic burden?	17157396
Coronary Arteriosclerosis	Stem Cell Exhaustion	The objective of this study was to examine if plasma concentrations of circulating stem cells and angiogenic cytokines in patients with severe stable chronic coronary artery disease were correlated to the clinical severity of the disease.	17157396
Hypoxia	Stem Cell Exhaustion	In particular, there is evidence that hypoxia promotes stem cell renewal in vitro as well as in vivo.	17158237
Hypoxia	Stem Cell Exhaustion	It therefore seems reasonable that stem cell survival and hypoxia response are strictly connected at molecular level.	17158237
Childhood Breast Carcinoma	Stem Cell Exhaustion	We here report that the 66-kDa isoform of the SHC gene (p66Shc) is induced in a breast cancer cell line by the exposure to hypoxic environment and that it controls the expression of the stem cell regulatory gene Notch-3.	17158237
Hypoxia	Stem Cell Exhaustion	We conclude that mechanisms that regulate stem cell renewal and hypoxia survival are integrated at the level of the p66Shc/Notch3 interplay.	17158237
Specialty Type - cancer	Stem Cell Exhaustion	The comprehension of the basic biology of stem cells is expected to provide a useful insight into the pathogenesis of cancer.	17158237
Childhood Breast Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Because Notch-3, Jagged-1, and carbonic anhydrase IX are dysregulated in breast cancer, and because p66Shc is an aging-regulating gene, we envision that these data may help in understanding the relationship among aging, cancer, and stem cells.	17158237
Hypoxia	Stem Cell Exhaustion	p66Shc/Notch-3 interplay controls self-renewal and hypoxia survival in human stem/progenitor cells of the mammary gland expanded in vitro as mammospheres.	17158237
Hypoxia	Stem Cell Exhaustion	Then, we show that p66Shc/Notch-3 interplay modulates self-renewal (by inducing the Notch-ligand Jagged-1) and hypoxia survival (by inducing the hypoxia-survival gene carbonic anhydrase IX) in mammary gland stem/progenitor cells, expanded in vitro as multicellular spheroids (mammospheres).	17158237
Diabetic Foot	Stem Cell Exhaustion	Autologous biograft and mesenchymal stem cells in treatment of the diabetic foot.	17159798
diabetic ulcer	Stem Cell Exhaustion	This study was performed to test a new technique for treatment of chronic non-healing wound (diabetic ulcer) using autologous biograft composed of autologous skin fibroblasts on biodegradable collagen membrane (Coladerm) in combination with autologous mesenchymal stem cells (MSC) derived from the patient's bone marrow.	17159798
Diabetes Mellitus	Stem Cell Exhaustion	Pioglitazone increases the numbers and improves the functional capacity of endothelial progenitor cells in patients with diabetes mellitus.	17161050
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Despite demonstrated mobilization of precursor stem cells in a timely fashion, in this small, pilot-scale randomized trial involving patients with large myocardial infarction, we were unable to demonstrate improvement in left ventricular function at 30 days.	17161051
Injury of liver	Stem Cell Exhaustion	Liver injury is a common complication in allogeneic hematopoietic stem cell transplantation.	17162212
Hodgkin Disease	Stem Cell Exhaustion	Long-term outcome of Hodgkin disease patients following high-dose busulfan, etoposide, cyclophosphamide, and autologous stem cell transplantation.	17162217
Histogenic Process, Specialty Type - cancer	Stem Cell Exhaustion	In such cases, Exo-cell and End-cell phenotypes were found to correlate strongly, suggesting the possibility of histogenesis from "cancer stem cells".	17163401
Malignant neoplasm of stomach	Stem Cell Exhaustion	We have previously suggested that an origin of a stomach cancer is from a progenitor cell specializing toward exocrine cell (Exo-cell) lineages.	17163401
Malignant neoplasm of stomach	Stem Cell Exhaustion	In conclusion, most stomach cancers might develop from a progenitor cell specializing towards Exo-cell lineages, but some cases possessed both Exo-cell and End-cell markers with maturely differentiated phenotypes.	17163401
Acute leukemia	Stem Cell Exhaustion	We assessed the cost-effectiveness of high-dose arabinoside (HiDAC)-based and allogeneic stem-cell transplantation (alloSCT)-based therapy in patients with acute leukemia.	17164232
Cerebrovascular accident	Stem Cell Exhaustion	Current concepts in adult stem cell therapy for stroke.	17168723
Cerebrovascular accident	Stem Cell Exhaustion	Stem cell therapies, such as adult stem cell transplantation, are promising strategies for the treatment of stroke.	17168723
Cerebrovascular accident	Stem Cell Exhaustion	This review provides an update on current preclinical cell-therapies for stroke, focusing on stem cells derived from adult sources.	17168723
IGA Glomerulonephritis, Acute lymphocytic leukemia	Stem Cell Exhaustion	Remission of IgA nephropathy after allogeneic peripheral blood stem cell transplantation followed by immunosuppression for acute lymphocytic leukemia.	17170503
Kidney Diseases, Acute lymphocytic leukemia, immunoglobulin A, BCR gene	Stem Cell Exhaustion	We report a case with immunoglobulin A (IgA) nephropathy, showing IgA deposition which disappeared after peripheral blood stem cell transplantation (PBSCT) for acute lymphocytic leukemia (ALL).	17170503
Analysis	Stem Cell Exhaustion	Nondiabetic, nondialyzed patients with ischemic limbs are strongly indicated for stem cell transplantation regardless of Fontaine classification.	17171401
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Autologous bone marrow-derived progenitor cell myocardial delivery for recent myocardial infarction patients following early angioplasty: results from a pilot study.	17174867
Acute myocardial infarction	Stem Cell Exhaustion	We report the results of a pilot study on progenitor cells in five patients with acute myocardial infarction (AMI).	17174867
Parenchyma	Stem Cell Exhaustion	Stem cell factor levels do increase in patients subsequent to hepatectomy with the extent of parenchymal loss.	17175329
PAFAH1B1 wt Allele, Multiple Myeloma, Myeloid Leukemia, Chronic, Leukemia, Myelocytic, Acute, BCR gene	Stem Cell Exhaustion	Thirteen patients with myeloma were treated with 200 mg/m2 L-PAM followed by autologous peripheral blood stem cell transplantation, and 13 patients (4 AML, 4 MDS, 2 ALL, 2 lymphoma and 1 CML) were treated with 140 mg/m2 L-PAM followed by allogeneic stem cell transplantation.	17176891
Specialty Type - cancer	Stem Cell Exhaustion	Effect of stem cell turnover rates on protection against cancer and aging.	17178130
Malignant Neoplasms, Stem cells	Stem Cell Exhaustion	An earlier biologically based model that was designed to estimate risks of high-dose radiation-induced solid cancers included initiation of stem cells to a premalignant state, inactivation of stem cells at high radiation doses, and proliferation of stem cells during cellular repopulation after inactivation.	17179481
Leukemia, Radiation-Induced	Stem Cell Exhaustion	To extend the model to radiation-induced leukemias, we analyzed--in addition to cellular initiation, inactivation, and proliferation--a repopulation mechanism specific to the hematopoietic system: long-range migration through the blood stream of hematopoietic stem cells (HSCs) from distant locations.	17179481
Atherosclerosis	Stem Cell Exhaustion	Reduced endothelial progenitor cells in European and South Asian men with atherosclerosis.	17181565
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Expression of the target receptor CD33 in CD34+/CD38-/CD123+ AML stem cells.	17181570
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In the present study, we asked whether leukaemic stem cells in patients with AML express CD33.	17181570
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	AML stem cells were purified by cell sorting and were examined for expression of CD33 mRNA by reverse transcriptase-polymerase chain reaction (RT-PCR).	17181570
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Repopulation experiments utilizing irradiated NOD/SCID mice confirmed that AML stem cells in these patients reside within the CD33(+) subpopulation of the leukaemic clone.	17181570
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Moreover, highly purified AML stem cells (> 98% purity) from patients with CD33(+) AML were found to express CD33 mRNA in RT-PCR analyses.	17181570
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Leukaemic stem cells in patients with CD33(+) AML express CD33.	17181570
Burn injury	Stem Cell Exhaustion	A 12-year-old girl with total limbal stem cell deficiency in the right eye following chemical burns underwent autologous cultivated limbal epithelium transplantation from the healthy left eye.	17181623
Hemorrhagic cystitis	Stem Cell Exhaustion	Risk factors and treatment of hemorrhagic cystitis in children who underwent hematopoietic stem cell transplantation.	17181656
Hepatitis B	Stem Cell Exhaustion	Permanent loss of anti-HBc after reactivation of hepatitis B virus infection in an anti-HBs and anti-HBc-positive patient after allogeneic stem cell transplantation.	17182277
Primary central nervous system lymphoma	Stem Cell Exhaustion	Primary central nervous system lymphoma treated with high-dose methotrexate, high-dose busulfan/thiotepa, autologous stem-cell transplantation and response-adapted whole-brain radiotherapy: results of the multicenter Ostdeutsche Studiengruppe Hamato-Onkologie OSHO-53 phase II study.	17185743
Primary central nervous system lymphoma, Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	We investigated the efficacy and safety of tandem high-dose methotrexate (HD-MTX) induction followed by high-dose busulfan/thiotepa (HD-BuTT) with autologous peripheral blood stem-cell transplantation (aPBSCT) and response-adapted whole-brain radiation therapy (WBRT) in patients with newly diagnosed primary central nervous system lymphoma.	17185743
Graft-vs-Host Disease, Hematologic Neoplasms, Uveitis, Chronic graft-versus-host disease	Stem Cell Exhaustion	To describe the occurrence of anterior uveitis along with systemic manifestations of chronic graft-versus-host disease (GVHD) after nonmyeloablative allogeneic hematopoietic stem cell transplantation (HSCT) in 3 patients with hematologic malignancies.	17187864
Stevens-Johnson Syndrome	Stem Cell Exhaustion	A comparison between cultivated and conventional limbal stem cell transplantation for Stevens-Johnson syndrome.	17188066
Inflammation, Schwartz-Jampel Syndrome, Stevens-Johnson Syndrome	Stem Cell Exhaustion	To compare the resolution of inflammation and long-term results of cultivated and conventional limbal stem cell transplantation (LSCT) in a patient with Stevens-Johnson syndrome (SJS).	17188066
Schwartz-Jampel Syndrome	Stem Cell Exhaustion	A 32-year-old man with SJS and bilateral total limbal stem cell deficiency underwent cultivated LSCT in the right eye, followed by conventional LSCT in the left eye three weeks later.	17188066
Lung Injury	Stem Cell Exhaustion	Of the 7 patients, 6 had a prior history of stem cell transplantation (SCT), whereas only 14 of 39 patients without lung injury had received SCT treatment (P = .033, Fisher exact test).	17189220
Allogeneic Hematopoietic Stem Cell Transplant Recipient, Meningoencephalitis	Stem Cell Exhaustion	Human herpesvirus 6 meningoencephalitis in allogeneic hematopoietic stem cell transplant recipients.	17189225
Meningoencephalitis	Stem Cell Exhaustion	We retrospectively investigated the clinical characteristics of human herpesvirus 6 (HHV-6) meningoencephalitis within 100 days after allogeneic hematopoietic stem cell transplantation (HSCT).	17189225
Chemotherapy-Related Leukemia	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (allo-HSCT) following myeloablative conditioning represents the treatment of choice for patients with chemotherapy-resistant leukemia.	17189227
Pancreatitis	Stem Cell Exhaustion	Cytomegalovirus (CMV)-associated pancreatitis is rare after allogeneic hematopoietic stem cell transplantation (SCT).	17189226
Polyendocrinopathies, Autoimmune	Stem Cell Exhaustion	Limbal stem cell deficiency in the context of autoimmune polyendocrinopathy.	17191197
Abnormal vision, Photophobia, Autoimmune Syndrome Type II, Polyglandular	Stem Cell Exhaustion	To report two sisters with bilateral progressive visual loss and photophobia secondary to stem cell deficiency due to multiple endocrine deficiency.	17191197
Degenerative polyarthritis	Stem Cell Exhaustion	Three-dimensional cartilage tissue engineering using adult stem cells from osteoarthritis patients.	17195220
Degenerative polyarthritis	Stem Cell Exhaustion	To determine whether it is possible to engineer 3-dimensional hyaline cartilage using mesenchymal stem cells derived from the bone marrow (BMSCs) of patients with osteoarthritis (OA).	17195220
Cerebrovascular	Stem Cell Exhaustion	Numeric and functional impairments of bone marrow-derived circulating endothelial progenitor cells (EPCs) are associated with increased cardiovascular and cerebrovascular morbidity and mortality.	17196460
Failure, Dermoid cyst of cornea, Keratoconus, Keratitis, Herpetic, Stromal Dystrophies, Corneal, Corneal Opacity	Stem Cell Exhaustion	Keratoconus was the main indication for surgery (58 eyes), followed by herpes simplex keratitis (6 eyes), corneal stromal dystrophy (5 eyes), stem cell failure with scarring (2 eyes), corneal dermoid (1 eye), and corneal opacity (1 eye).	17198015
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	To determine the response of bone marrow progenitor cells from patients with myelodysplastic syndromes (MDS) to culture in physiologic oxygen tension.	17198870
immunoglobulin A	Stem Cell Exhaustion	The first patient diagnosed as IgA IIIA stage, whose state of disease became worse after 8 months of autologous peripheral blood stem cell transplantation.	17204182
Esophageal Mucositis, Gastrointestinal mucositis	Stem Cell Exhaustion	Oral mucositis is recognised as one of the most debilitating complications of high-dose cytostatic chemotherapy used to prepare for haematopoietic stem cell transplantation (HSCT), but very little is known about oesophageal mucositis, as endoscopy is not routinely performed.	17205279
Prostate carcinoma	Stem Cell Exhaustion	CD133 is a putative hematopoietic and neuronal stem-cell marker, which was also considered as a tumorigenic marker in brain and prostate cancer.	17205516
Neutropenia	Stem Cell Exhaustion	The median time from peripheral blood progenitor cell infusion to onset of neutropenia was 5 days (range, 4-6 days), and the mean duration of neutropenia was 5 days (range, 4-7 days).	17207239
varicella zoster, Degenerative polyarthritis	Stem Cell Exhaustion	Human parvovirus B19, varicella zoster virus, and human herpesvirus-6 in mesenchymal stem cells of patients with osteoarthritis: analysis with quantitative real-time polymerase chain reaction.	17207644
Degenerative polyarthritis	Stem Cell Exhaustion	To investigate whether there is a possible viral transmission using mesenchymal stem cells (MSCs) in autologous or allogeneic transplantation in the context of osteoarthritis (OA) patients.	17207644
Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	The cited assumption allows us to: (1) explain reverse dependence of cell proliferation due to the level of their differentiation, increase in the amount and activity of mitochondria as an indispensable condition for the disbalance shift towards differentiation, (2) bring up the idea that regress of the cells, and in particular tumour cells, directly results from the Delta(PO-AO) disbalance decrease to certain levels under the influence of reverse inductors, (3) explain relatively easy and frequent embryonic and stem cells malignancy, and also their reversal normalization.	17207937
Bronchopulmonary Dysplasia	Stem Cell Exhaustion	Hyperoxia reduces bone marrow, circulating, and lung endothelial progenitor cells in the developing lung: implications for the pathogenesis of bronchopulmonary dysplasia.	17209139
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Results of a HOVON/SAKK donor versus no-donor analysis of myeloablative HLA-identical sibling stem cell transplantation in first remission acute myeloid leukemia in young and middle-aged adults: benefits for whom?	17213292
Mobilized Peripheral Blood Stem Cell, Medulloblastoma	Stem Cell Exhaustion	Pilot study of ifosfamide/carboplatin/etoposide (ICE) for peripheral blood stem cell mobilization in patients with high-risk or relapsed medulloblastoma.	17226035
Medulloblastoma	Stem Cell Exhaustion	The purpose of this study is to evaluate the stem cell mobilization capacity, anti-tumor effect, and feasibility of ifosfamide/carboplatin/etoposide (ICE) for transplant-eligible patients with medulloblastoma.	17226035
Toxic effect, Medulloblastoma	Stem Cell Exhaustion	These results suggest that ICE is optimal for mobilizing stem cells, effective for high-risk or relapsed medulloblastoma, and tolerable with limited non-hematological toxicity.	17226035
Graft-vs-Host Disease	Stem Cell Exhaustion	Nonmyeloablative therapy using haploidentical family member donors is feasible because the main obstacles of GVHD and graft rejection are manageable, allowing readily available stem-cell donors to be found for nearly all patients.	17228020
Multiple Myeloma	Stem Cell Exhaustion	Phase I trial of first-line bortezomib/thalidomide plus chemotherapy for induction and stem cell mobilization in patients with multiple myeloma.	17229337
Multiple Myeloma	Stem Cell Exhaustion	This novel strategy of simultaneous proteasome inhibition in combination with thalidomide and chemotherapy was effective and safe, allowing for adequate stem cell collection and early autologous SCT; its impact on overall survival, especially in patients with high-risk myeloma, awaits further investigation.	17229337
Hodgkin Disease	Stem Cell Exhaustion	Prognostic impact of pretransplantation computed tomography and gallium scans in patients with Hodgkin lymphoma with poor prognosis undergoing hematopoietic stem cell transplantation.	17229338
Hodgkin Disease	Stem Cell Exhaustion	The present study evaluated computed tomography (CT) and Gallium-67 scanning (67Ga) before transplantation as prognostic factors for overall survival (OS) and event-free survival (EFS) in patients with relapsed or primary refractory Hodgkin lymphoma undergoing high-dose chemotherapy and stem cell transplantation.	17229338
Neoplasms, Central neuroblastoma, niobium	Stem Cell Exhaustion	The aim of the paper was to improve the prognosis of neuroblastoma (NB) stage III and IV in children through the comprehensive therapy including chemotherapy, delayed tumor resection, autologous stem cell transplantation (ASCT) and inducing differentiation and to analyze the factors affecting the prognosis.	17229383
Mantle cell lymphoma	Stem Cell Exhaustion	Rituximab-augmented myeloablation for first-line autologous stem cell transplantation for mantle cell lymphoma: effects on molecular response and clinical outcome.	17229634
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) is effective in mantle cell lymphoma (MCL).	17229634
Medial collateral ligament	Stem Cell Exhaustion	In a prospective phase II study, patients with newly diagnosed MCL were treated with a sequential dose-escalating therapy comprising standard chemotherapy for remission induction, intensive ara-C-containing chemotherapy for mobilization of stem cells, and myeloablative therapy followed by ASCT.	17229634
Peripheral T-Cell Lymphoma, Lymphoma	Stem Cell Exhaustion	The results of consolidation with autologous stem-cell transplantation in patients with peripheral T-cell lymphoma (PTCL) in first complete remission: the Spanish Lymphoma and Autologous Transplantation Group experience.	17229774
Lung Injury	Stem Cell Exhaustion	Of the 7 patients, 6 had a prior history of stem cell transplantation (SCT), whereas only 14 of 39 patients without lung injury had received SCT treatment (p = 0.033 by Fischer's exact test).	17233470
Neutropenia	Stem Cell Exhaustion	Risk factors independently associated with all-cause mortality include impairment in pulmonary function before HCT, receipt of human leukocyte antigen-mismatched stem cells, neutropenia, elevated bilirubin and creatinine levels, receipt of corticosteroids at > or =2 mg/kg per day, disseminated and proven IA, and IA occurring >40 days after HCT.	17243056
Central neuroblastoma	Stem Cell Exhaustion	Iodine-131-metaiodobenzylguanidine therapy with reduced-intensity allogeneic stem cell transplantation in recurrent neuroblastoma.	17243128
Central neuroblastoma	Stem Cell Exhaustion	We describe the case history of a 3-year-old girl with recurrent neuroblastoma who received MIBG therapy with reduced-intensity allogeneic stem cell transplantation (RIST) because of an extensive bone marrow involvement.	17243128
Hematologic Neoplasms	Stem Cell Exhaustion	High-dose caspofungin combination antifungal therapy in patients with hematologic malignancies and hematopoietic stem cell transplantation.	17245424
Myeloproliferative disease, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myelogenous leukemia (CML) is a malignant myeloproliferative disorder that originates from a pluripotent stem cell expressing the bcr-abl oncogene.	17245764
Mycoses	Stem Cell Exhaustion	Invasive fungal infections are an important cause of morbidity and mortality after allogeneic hematopoietic stem-cell transplantation.	17251530
Ischemia	Stem Cell Exhaustion	Safety and efficacy of autologous progenitor cell transplantation for therapeutic angiogenesis in patients with critical limb ischemia.	17251666
Graft-vs-Host Disease, Deteriorating vision, Photophobia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 50-year-old man with history of acute myeloblastic leukemia, high-dose chemotherapy for eradication of hematopoietic stem cells, subsequent allogenic bone marrow transplantation, and eventually GVHD was referred for decreased vision and photophobia.	17251819
Sample Size Calculation	Stem Cell Exhaustion	Twenty-seven SSc patients underwent 45 skin biopsies with simultaneous measure of mRSS before or after treatment by immunosuppressive drugs, with or without autologous peripheral haematopoietic stem cell transplantation (HSCT).	17255134
Diabetes, Hypoxia	Stem Cell Exhaustion	Diabetes impairs endothelial progenitor cell-mediated blood vessel formation in response to hypoxia.	17255657
Hypoxia, Ischemia, Diabetes, Diabetic Angiopathies	Stem Cell Exhaustion	Because endothelial progenitor cells are known to home to sites of ischemia and participate in new blood vessel growth, the authors examined the effects of diabetes on human endothelial progenitor cell function and peripheral tissue signaling in hypoxia, and determined whether these cells might be a useful cell-based therapy for diabetic vascular complications.	17255657
Diabetes, Hypoxia	Stem Cell Exhaustion	These findings suggest that diabetes causes defects in both the endothelial progenitor cell and peripheral tissue responses to hypoxia.	17255657
Complications of Diabetes Mellitus	Stem Cell Exhaustion	Based on these findings, it is unlikely that endothelial progenitor cell-based cellular therapies will be able to prevent diabetic complications.	17255657
diabetic	Stem Cell Exhaustion	Circulating human endothelial progenitor cells from type 2 diabetic patients and controls were isolated and subjected to in vitro adhesion, migration, and proliferation assays (n = 5).	17255657
Hypoxia	Stem Cell Exhaustion	Adhesion, migration, and proliferation of human diabetic endothelial progenitor cells in response to hypoxia was significantly reduced compared with controls.	17255657
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	High-dose chemotherapy and autologous stem cell transplantation for peripheral T-cell lymphoma: complete response at transplant predicts survival.	17256144
Aggressive Non-Hodgkin Lymphoma, Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Although the role of high dose chemotherapy (HDT) and autologous stem cell transplantation (ASCT) in the treatment of aggressive lymphoma has been established in several large prospective studies, its effectiveness in patients with peripheral T cell lymphoma (PTCL) has not been defined.	17256144
Fracture, Hematoma	Stem Cell Exhaustion	An in vitro study demonstrating that haematomas found at the site of human fractures contain progenitor cells with multilineage capacity.	17259432
Fracture, Hematoma	Stem Cell Exhaustion	We isolated multilineage mesenchymal progenitor cells from haematomas collected from fracture sites.	17259432
Fracture, Hematoma	Stem Cell Exhaustion	Our results indicate that haematomas found at a fracture site contain multilineage mesenchymal progenitor cells and play an important role in bone healing.	17259432
Chronic granulomatous disease, Aspergillosis	Stem Cell Exhaustion	Patients with chronic granulomatous disease (CGD) complicated by antimycotics-refractory invasive aspergillosis have an extremely poor prognosis if they cannot undergo allogeneic hematopoietic stem cell transplantation from a suitable related donor while in good clinical condition.	17261504
Chronic granulomatous disease	Stem Cell Exhaustion	We postulate that reduced-intensity conditioning-allogeneic hematopoietic stem cell transplantation is a promising therapeutic strategy for patients with CGD even if only unrelated-donor umbilical cord blood is available.	17261504
Leukemia, Myelocytic, Acute, Thrombophlebitis, Cellulitis	Stem Cell Exhaustion	Successful stem cell transplantation without cryopreservation from a microchimeric haploidentical sibling for refractory acute myeloid leukemia complicated with critical thrombophlebitis and cellulitis.	17261507
Communicable Diseases	Stem Cell Exhaustion	Because of the necessity for early neutrophil recovery to resolve the critical infection, we proceeded with allogeneic peripheral blood stem cell transplantation (PBSCT) from a microchimeric haploidentical sibling donor.	17261507
Vascular System Injuries	Stem Cell Exhaustion	It has been hypothesized that the inflammatory response after vascular injury triggers the mobilization of endothelial and smooth muscle progenitor cells from bone marrow.	17261663
Cytomegalovirus Infections	Stem Cell Exhaustion	Patients at high risk for CMV infection and disease show delayed CD8+ T-cell immune recovery after allogeneic stem cell transplantation.	17262060
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Chimerism analysis within 6 months of allogeneic stem cell transplantation predicts relapse in acute myeloid leukemia.	17262061
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation is safe and feasible in elderly patients with multiple myeloma.	17262062
Multiple Myeloma	Stem Cell Exhaustion	Several clinical trials have shown the superiority of autologous stem cell transplantation over conventional dose therapy for patients with multiple myeloma.	17262062
platelet dysfunction, Portal Vein Thrombosis, Myeloproliferative disease	Stem Cell Exhaustion	Patients with primary myeloproliferative disorders are at increased risk of portal vein thrombosis, independent of surgical intervention, perhaps due to platelet dysfunction resulting from abnormalities of pluripotent stem cells.	17262159
Multiple Myeloma	Stem Cell Exhaustion	Autologous peripheral blood stem cell transplantation in multiple myeloma using oral versus I.V.	17262193
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Autologous peripheral blood stem cell transplantation is the therapy of choice for the treatment of multiple myeloma (MM) patients younger than 70 years old.	17262193
Leukoencephalopathy	Stem Cell Exhaustion	Fatal leukoencephalopathy after reduced-intensity allogeneic stem cell transplantation.	17264526
neurological complication, Toxic effect	Stem Cell Exhaustion	Toxicity associated with immunosuppression and conditioning regimens represents a common cause of neurological complications after allogeneic stem cell transplantation.	17264526
Acute lymphocytic leukemia	Stem Cell Exhaustion	We present a 56-year-old female patient with refractory acute lymphoblastic leukemia undergoing reduced-intensity conditioning with fludarabine, BCNU and melphalan followed by matched-sibling allogeneic stem cell transplantation.	17264526
Immune thrombocytopenic purpura, Decreased platelet count	Stem Cell Exhaustion	Reticulated platelet counts correlate with treatment response in patients with idiopathic thrombocytopenic purpura and help identify the complex causes of thrombocytopenia in patients after allogeneic hematopoietic stem cell transplantation.	17266149
Retinitis Pigmentosa, PAFAH1B1 wt Allele, Immune thrombocytopenic purpura, Liver Cirrhosis, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We used a whole blood flow cytometry method combining thiazole orange and anti-CD41a-staining to assess RP in 71 healthy subjects, six with thrombocytopenic myelodysplastic syndrome (MDS), nine with liver cirrhosis, 14 patients with idiopathic thrombocytopenic purpura (ITP), and 12 patients who had undergone hematopoietic stem cell transplantation (HSCT).	17266149
Pregnancy Complications, Infectious, Multiple Organ Failure	Stem Cell Exhaustion	The patient died because of infectious complications with subsequent multi-organ failure while awaiting work up for autologous stem cell transplantation.	17268546
Prostate, Carcinoma	Stem Cell Exhaustion	Most widely accepted view is that SCCP arises from pluripotent stem cells of the prostate, which have the ability to differentiate into either epithelial or neuroendocrine type carcinomas.	17268913
Peripheral Blood Stem Cells, Febrile Neutropenia, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology	Stem Cell Exhaustion	Long term results of a phase II trial of induction chemotherapy with uracil-ftegafur (UFT), vinorelbine and cisplatin (UFTVP) followed by radiotherapy concomitant with UFT and carboplatin (RT/UFTJ) in non-resectable locally advanced (stage IV-B) squamous cell head and neck carcinoma and peripheral blood stem cell support (PBSCS) with febrile neutropenia.	17272229
Myeloproliferative disease	Stem Cell Exhaustion	Indeed, evidence from our group and others has suggested that two of the most clinically significant age-associated hematological conditions, namely, the diminution of the adaptive immune system and the elevated incidence of myeloproliferative diseases, have their origin in cell autonomous changes in the functional capacity of hematopoietic stem cells.	17275237
Stevens-Johnson Syndrome	Stem Cell Exhaustion	We studied 6 eyes from 5 patients with total corneal stem cell destruction; 3 eyes were from patients with Stevens-Johnson syndrome and 3 eyes had sustained chemical injury.	17275911
Cartilage	Stem Cell Exhaustion	The purpose of this study was to evaluate the repaired tissues formed in full-thickness cartilage defects in a rabbit model implanted with 4 types of chondrogenic cells, including chondrocytes, mesenchymal stem cells (MSCs) and fibroblasts from rabbit, and human umbilical cord blood (hUCB) stem cells.	17276226
Cartilage	Stem Cell Exhaustion	Full-thickness cartilage defects treated with chondrocyte or MSC transplantation were repaired with hyaline-like cartilage tissue, and repair was significantly better than in tissues treated with fibroblasts and hUCB stem cells, as well as in the control group.	17276226
Neutropenia, Inflammation, Immunocompromised Host, Communicable Diseases	Stem Cell Exhaustion	We therefore compared the patterns of infection and inflammation among 3 cohorts of immunocompromised patients with profound neutropenia, nonneutropenic immunosuppression, and hematopoietic stem cell transplantation.	17276936
Neutropenia, Diffuse alveolar hemorrhage	Stem Cell Exhaustion	Lesions of IPA in neutropenic patients and hematopoietic stem cell transplant (HSCT) recipients were similar and consisted predominantly of angioinvasion and intraalveolar hemorrhage.	17276936
Congestive heart failure	Stem Cell Exhaustion	Circulating endothelial progenitor cells and clinical outcome in patients with congestive heart failure.	17277352
Ischemia	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPCs) are increased in conditions associated with ischaemia and can potentially support angiogenesis and vasculogenesis.	17277352
Acute GVH disease, Chronic graft-versus-host disease, Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation	Stem Cell Exhaustion	Histological evaluation of acute mucocutaneous graft-versus-host disease in nonmyeloablative hematologic stem cell transplants with an observation predicting an increased risk of progression to chronic graft-versus-host disease.	17284954
Hematological Disease	Stem Cell Exhaustion	Autologous peripheral blood stem cells transplantation (PBSCT) is a therapeutic option which can be used in various hematological neoplastic disorders; and it can prolong disease free survival and total survival and at times it may be curative.	17292672
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	[Allogeneic hematopoietic stem cell transplantation in patients with chronic myeloid leukemia in the Czech Republic--a retrospective analysis of results in years 1988-2005].	17299910
Kidney Failure, Multiple Myeloma	Stem Cell Exhaustion	We present our community experience with multiple myeloma patients with advanced age, long disease duration since diagnosis, advanced stage, multiple prior therapies including stem cell transplantation, co-morbidities, and other poor prognostic features, such as low albumin, high B-2 microglobulin, renal failure, and the presence of poor risk chromosomal abnormalities.	17301970
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Inv (11)(p15q21) in donor-derived Ph-negative cells in a patient with chronic myeloid leukemia in relapse successfully treated with imatinib mesylate post allogeneic stem cell transplantation.	17301975
Myeloid Leukemia, Chronic, Chromosome Aberrations	Stem Cell Exhaustion	Following hematopoietic stem cell transplantation (HSCT), IM induces complete molecular responses (CMR) in approximately 70% patients with relapsed CML, and no IM-related cytogenetic abnormalities in Ph-negative donor-derived cells have been described after HSCT.	17301975
Coronary Arteriosclerosis	Stem Cell Exhaustion	G-CSF-induced mobilization of CD34(+) progenitor cells and proarrhythmic effects in patients with severe coronary artery disease.	17302697
Coronary Arteriosclerosis, Ischemia	Stem Cell Exhaustion	The in vivo mobilization of endothelial progenitor cells (EPCs) and the possible proarrhythmic effects in patients with severe coronary artery disease (CAD) and inducible ischemia have not been described.	17302697
Rheumatoid Arthritis	Stem Cell Exhaustion	Similarly, treatment of postnatal d 3 rat gonocytes with RA induced a dose-dependent increase in V1-PDGFRbeta expression together with an increase in c-kit and Stra8, markers of more differentiated germ cells and a concomitant decrease in GFRalpha1, a marker of spermatogonial stem cells.	17303670
Atherosclerosis	Stem Cell Exhaustion	Remnant like particles may induce atherosclerosis via accelerating endothelial progenitor cells senescence.	17306468
Graft-vs-Host Disease, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The therapeutic value of donor lymphocyte infusions in patients who relapse with acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (HSCT) is limited by a low efficacy and the risk of graft-versus-host disease.	17308369
Achromia of skin, Hypopigmentation disorder	Stem Cell Exhaustion	Even if we do not know the clinical significance of the skin depigmentation caused by IM, the regulatory role of KIT and its ligand stem cell factor in melanocyte development and survival seems to suggest an objective mechanism of action for IM in the pathogenesis of this cutaneous depigmentation.	17309464
Zygomycosis, Hematologic Neoplasms	Stem Cell Exhaustion	Breakthrough zygomycosis after voriconazole administration among patients with hematologic malignancies who receive hematopoietic stem-cell transplants or intensive chemotherapy.	17310132
Specialty Type - cancer	Stem Cell Exhaustion	A higher proportion of cases reported over the last decades have been in cancer patients, with or without hematopoietic stem cell transplantation (HSCT).	17310132
Multiple Myeloma	Stem Cell Exhaustion	Reduced-toxicity conditioning with fludarabine and treosulfan prior to allogeneic stem cell transplantation in multiple myeloma.	17310135
Non-Malignant	Stem Cell Exhaustion	Fludarabine-based disease-specific conditioning or conventional myeloablative conditioning in hematopoietic stem cell transplantation for treatment of non-malignant diseases.	17310137
Complete Blood Count, Non-Malignant	Stem Cell Exhaustion	Fludarabine-based conditioning (FBC) was given to 24 patients and conventional myeloablative conditioning (MC) to 33 patients, most children, before hematopoietic stem cell transplantation (HSCT) for non-malignant diseases.	17310137
Malignant Neoplasms	Stem Cell Exhaustion	To prospectively evaluate the effectiveness of portal vein embolization (PVE) and CD133(+) bone marrow stem cell (BMSC) administration to the liver, compared with PVE alone, to augment hepatic regeneration in patients with large hepatic malignancies.	17312278
B-Cell Lymphomas	Stem Cell Exhaustion	High-dose [131I]tositumomab (anti-CD20) radioimmunotherapy and autologous hematopoietic stem-cell transplantation for adults > or = 60 years old with relapsed or refractory B-cell lymphoma.	17312330
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	The majority of patients with relapsed or refractory B-cell non-Hodgkin's lymphoma (NHL) are older than 60 years, yet they are often denied potentially curative high-dose therapy and autologous stem-cell transplantations (ASCT) because of the risk of excessive treatment-related morbidity and mortality.	17312330
Disease	Stem Cell Exhaustion	These diseases are clonal stem cell disorders arising in an early stem cell progenitor.	17313377
Disease, Myeloid-Lymphoid Leukemia Protein	Stem Cell Exhaustion	These results demonstrate the origin of the JAK2 V617F positive disorders in an early stem cell with both lymphoid and myeloid differentiation potential.	17313377
Hodgkin Disease, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Ifosphamide, etoposide and epirubicin is an effective combined salvage and peripheral blood stem cell mobilisation regimen for transplant-eligible patients with non-Hodgkin lymphoma and Hodgkin disease.	17313378
Peripheral Blood Stem Cells, Hodgkin Disease, Lymphoma, Non-Hodgkin, Familial, HD Term Type, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	A total of 143 patients with relapsed (n = 90), primary refractory (n = 32) and first line chemotherapy responsive (n = 21) non-Hodgkin lymphoma (NHL) and Hodgkin disease (HD) were treated with IVE (ifosphamide, etoposide and epirubicin) chemotherapy with the intent to proceed to high-dose therapy with either autologous or allogeneic transplantation, following peripheral blood stem cell mobilisation.	17313378
Cytomegalovirus Infections, Kidney Failure	Stem Cell Exhaustion	Leflunomide failure to control recurrent cytomegalovirus infection in the setting of renal failure after allogeneic stem cell transplantation.	17313468
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	We report the case of a CMV-seropositive 46-year-old man with non-Hodgkin's lymphoma who underwent an unrelated allogeneic stem cell transplant from a CMV-seronegative HLA-matched unrelated donor.	17313468
Cytomegalovirus Infections	Stem Cell Exhaustion	Options for salvage therapy in refractory CMV disease in allogeneic stem cell transplant recipients are briefly reviewed.	17313468
Lymphoma	Stem Cell Exhaustion	Our goal was to optimize use of granulocyte colony-stimulating factor (G-CSF) after high-dose chemotherapy and autologous peripheral blood stem-cell transplantation in lymphoma patients, limiting G-CSF administration to patients infusing a suboptimal CD34(+) cell number.	17313558
HODGKINS AND NON-HODGKINS LYMPHOMA	Stem Cell Exhaustion	Of 124 consecutive patients with histologically proven Hodgkin's and non-Hodgkin's lymphoma from January 2001 to June 2004, 60 patients (group 1) given > or = 5 x 10(6)/kg CD34(+) cells received no G-CSF; 64 patients (group 2) given < or = 5 x 10(6)/kg CD34(+) cells received G-CSF from day +5 after stem-cell reinfusion.	17313558
Epithelial, Keratopathy, Bulla, trauma qualifier	Stem Cell Exhaustion	Of the 233 transplants, there were 126 (54.1%) valid outcome returns: the outcome for persistent epithelial defects was a healed and stable surface in 11/35 (31.4%, 95% CI 16.9 to 49.3); for chemical/thermal injuries, a healed uninflamed eye with clear cornea in 5/18 (27.8%, 95% CI 9.7 to 53.4); for bullous keratopathy a pain-free, stable surface without bullae in 4/18 (22.2%, 95% CI 6.4 to 47.6); for ocular surface reconstruction, an epithelialised uninflamed conjunctiva without scarring in 12/23 (52.2%, 95% CI 30.6 to 73.2); and for limbal stem cell deficiency, a corneal phenotype in 4/7 (57.1%).	17314154
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Toll-like receptor-4 is up-regulated in hematopoietic progenitor cells and contributes to increased apoptosis in myelodysplastic syndromes.	17317824
Impaired	Stem Cell Exhaustion	Hematopoietic stem cell transplantation causes long term endocrine complications especially impaired growth.	17317915
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) has an important role in the treatment of multiple myeloma (MM) patients.	17319788
Infarction	Stem Cell Exhaustion	Bone marrow was harvested from the iliac crest one day before surgery, and purified CD133+ progenitor cells were injected in the infarct border zone during the CABG operation.	17320570
Vascular Diseases	Stem Cell Exhaustion	Recently, it has been proposed that statins mobilize endothelial progenitor cells from bone marrow during the first four weeks, which could help to prevent vascular diseases.	17320859
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Intracoronary delivery of umbilical cord blood derived unrestricted somatic stem cells is not suitable to improve LV function after myocardial infarction in swine.	17320899
Heart failure	Stem Cell Exhaustion	Regeneration of infarcted myocardium by injecting stem cells has been proposed to prevent heart failure.	17320899
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	administration of human umbilical cord blood stem cells (USSC) in a porcine model of myocardial infarction (MI) and reperfusion.	17320899
Multiple Myeloma	Stem Cell Exhaustion	A 39-year-old male with multiple myeloma was admitted for treatment with melphalan and autologous stem cell reinfusion.	17322929
Acute Promyelocytic Leukemia	Stem Cell Exhaustion	Hematopoietic stem cell transplantation for adults with acute promyelocytic leukemia in the ATRA era: a survey of the European Cooperative Group for Blood and Marrow Transplantation.	17322930
Acute Promyelocytic Leukemia, ATRICHIA WITH PAPULAR LESIONS	Stem Cell Exhaustion	We performed a survey of the European Cooperative Group for Blood and Marrow Transplantation to analyze the outcome of 625 acute promyelocytic leukemia (APL) patients transplanted with auto- or allogeneic-hematopoietic stem cell transplantation (autoHSCT, alloHSCT) after 1993, in first (CR1) or in second complete remission (CR2).	17322930
Li-Fraumeni Syndrome	Stem Cell Exhaustion	In the alloHSCT group for CR1 (n=144), age (<33 years) was associated with increased LFS and decreased TRM and for CR2 (n=137), the use of mobilized peripheral blood stem cells was associated with decreased TRM.	17322930
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	AMD3100 affects autograft lymphocyte collection and progression-free survival after autologous stem cell transplantation in non-Hodgkin lymphoma.	17324341
Lymphoma, Non-Hodgkin, Familial, Hodgkin Disease	Stem Cell Exhaustion	Autograft absolute lymphocyte count (A-ALC) affects survival after autologous stem cell transplantation (ASCT) in non- Hodgkin lymphoma (NHL).	17324341
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	AMD3100, a CXCR4 antagonist, mobilizes CD34+ stem cells in patients with NHL undergoing ASCT.	17324341
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Long-term follow-up of Asian patients younger than 46 years with acute myeloid leukemia in first complete remission: comparison of allogeneic vs. autologous hematopoietic stem cell transplantation.	17325850
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Optimal therapy for patients with acute myeloid leukemia (AML) in first complete remission (CR-1) remains the subject of debate: with the possibilities of chemotherapy alone, autologous (auto) or allogeneic (allo) hematopoietic stem cell transplantation (HSCT).	17325850
Polycythemia Vera, Hyperplasia	Stem Cell Exhaustion	Polycythemia vera (PV), an acquired, chronic, clonal disorder arising in a multipotential hematopoietic progenitor cell, is characterized by hyperplasia of three major myeloid lineages, with a pronounced increase in cells of the erythroid lineage.	17325857
Lymphoproliferative Disorders	Stem Cell Exhaustion	Early lymphocyte recovery following autologous peripheral stem cell transplantation is associated with better survival in younger patients with lymphoproliferative disorders.	17325956
Neoplasms	Stem Cell Exhaustion	Nonmyeloablative allogeneic blood stem cell transplantation in patients with metastatic solid tumors.	17325957
Neoplasms	Stem Cell Exhaustion	The aim of the study was to evaluate the feasibility and efficacy of a non-myeloablative regimen to achieve complete donor chimerism after stem cell transplantation (SCT) in patients with metastatic solid tumors.	17325957
Sweet Syndrome, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Successful reduced-intensity stem cell transplantation in a patient with myelodysplastic syndrome combined with Sweet's syndrome.	17325958
Sweet Syndrome, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	A 53-year-old male with myelodysplastic syndrome developed Sweet's syndrome extensively over his left iliac and inguinal regions that was refractory to standard treatment with corticosteroids and chemotherapy, received a stem cell transplant from an HLA-matched unrelated donor, conditioned by reduced-intensity regimen.	17325958
Pterygium	Stem Cell Exhaustion	Overall, these results suggest that adult bone marrow- derived progenitor cells, such as endothelial progenitor cells and mesenchymal stem cells, are involved in the wound healing process post-excision in patients with pterygium.	17326245
Pterygium	Stem Cell Exhaustion	In order to investigate the involvement of these cells in wound healing after a pterygium excision, immunohistochemical staining was performed with a temporary amniotic membrane, applied to the bare sclera, after a pterygium excision using various progenitor cell markers, including CD34, c-kit, STRO-1, and AC133, to determine the expression levels of the participating cells.	17326245
Pterygium	Stem Cell Exhaustion	Progenitor cells in healing after pterygium excision.	17326245
Tissue damage, Pterygium	Stem Cell Exhaustion	Bone marrow derived progenitor cells were reported to be involved in the pathogenesis of pterygium and have been suggested to be important in angiogenesis and the repair process after tissue damage.	17326245
Diabetes	Stem Cell Exhaustion	Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes.	17327434
Central Nervous System, Vasculitis, CTCAE	Stem Cell Exhaustion	Central nervous system (CNS) vasculitis was thus attributed to the perforin deficiency, and the patient was successfully treated by transplantation of stem cells from an HLA-identical brother.	17328077
Anemia, Sickle Cell	Stem Cell Exhaustion	We describe a previously unreported case of a 16-year-old female sickle cell disease patient with anti-CD36 antibodies, detected on routine screen prior to hematopoietic stem cell transplantation (HSCT).	17330834
Adenovirus Infections	Stem Cell Exhaustion	Assessment of disseminated adenovirus infections using quantitative plasma PCR in adult allogeneic stem cell transplant recipients receiving reduced intensity or myeloablative conditioning.	17331130
Infection	Stem Cell Exhaustion	Disseminated adenovirus (AdV) infections following allogeneic stem cell transplantation (allo-SCT) are increasingly recognised, particularly in children.	17331130
Glioma, Neoplasms	Stem Cell Exhaustion	The presence of a CD133+/nestin+ population in brain tumors suggests that a normal neural stem cell may be the cell of origin for gliomas.	17332509
Adult Glioblastoma, Specialty Type - cancer	Stem Cell Exhaustion	Spontaneous transformation of human adult nontumorigenic stem cells to cancer stem cells is driven by genomic instability in a human model of glioblastoma.	17332509
Specialty Type - cancer, Neoplasms, Intracranial	Stem Cell Exhaustion	Replicative senescence in HNGC-1 led to a high level of genomic instability and emergence of a spontaneously immortalized clone that developed into cell line HNGC-2 with features of cancer stem cells (CSCs), which include the ability for self-renewal and the capacity to form CD133-positive neurospheres and develop intracranial tumors.	17332509
Neoplasms	Stem Cell Exhaustion	The activated forms of Notch and Hes isoforms were expressed in both non-neoplastic neural stem cells and brain tumor stem cells derived from it.	17332509
Neoplasms	Stem Cell Exhaustion	Importantly, a significant overexpression of these molecules was found in the brain tumor stem cells.	17332509
Specialty Type - cancer	Stem Cell Exhaustion	These findings suggest that this model comprised of HNGC-1 and HNGC-2 cells would be a useful system for studying pathways involved in self-renewal of stem cells and their transformation to cancer stem cells.	17332509
Fibrous Dysplasia, fibroma	Stem Cell Exhaustion	First, we examined the difference between fibrous dysplasia and ossifying fibroma in the expression of Runx2 (which determined osteogenic differentiation from mesenchymal stem cells) and other osteogenic markers.	17334331
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Exogenous chemokines usually did not have any effect on AML blast proliferation in the absence of hematopoietic growth factors, but when investigating growth factor-dependent (interleukin 3 + granulocyte-macrophage colony-stimulating factor + stem cell factor) proliferation in suspension cultures the following patient subsets were identified: (i) patients whose cells showed chemokine-induced growth enhancement (8 patients); (ii) divergent effects on proliferation (15 patients); and (iii) no effect (most patients).	17339182
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Autologous stem cell transplantation after complete remission and first consolidation in acute myeloid leukemia patients aged 61-70 years: results of the prospective EORTC-GIMEMA AML-13 study.	17339189
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Key words: acute myeloid leukemia, elderly, autologous stem cell transplantation.	17339189
Multiple Myeloma	Stem Cell Exhaustion	We report for the first time that a gene's expression mainly in the BM environment (ie, HSPE) is associated with a shorter event-free survival of patients with newly diagnosed myeloma treated with high-dose chemotherapy and stem cell transplantation.	17339423
Virus Diseases	Stem Cell Exhaustion	Possible explanations for this association include a genetic predisposition, alterations in early progenitor cells, underlying viral infections, and/or stimulation of a B-cell clone by the malignant helper T cells of the primary CTCL and vice versa.	17340135
Blast Phase, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Despite advances in drug therapy and allogeneic stem cell transplantation (allo-SCT), the prognosis of patients with chronic myeloid leukemia (CML) in blast crisis remains poor.	17340589
Cytogenetically normal acute myeloid leukemia, MLL Partial Tandem Duplication	Stem Cell Exhaustion	Intensive consolidation therapy that included autologous peripheral stem-cell transplantation during CR1 may have contributed to the better outcome of this historically poor-prognosis group of CN-AML patients with MLL-PTD.	17341662
Prostate carcinoma, prostate stem cell antigen	Stem Cell Exhaustion	External beam radiotherapy (EBRT) suppressed prostate stem cell antigen (PSCA) mRNA expression in clinically localized prostate cancer.	17342746
Prostate carcinoma, Passive Cutaneous Anaphylaxis	Stem Cell Exhaustion	Prostate stem cell antigen (PSCA), a recently identified glycosylphosphatidylinositol (GPI)-anchored cell surface protein belonging to the Thy-1/Ly-6 family of cell surface antigens, is overexpressed in human prostate cancer (PCa).	17342746
MYELOPROLIFERATIVE SYNDROME, TRANSIENT	Stem Cell Exhaustion	The Val617Phe point mutation of Janus kinase 2 gene is believed to participate in the pathogenesis of myeloproliferative syndrome characterised by the clonal alteration of hematopoietic stem cells.	17344140
Multiple Myeloma	Stem Cell Exhaustion	Bone marrow mesenchymal stem cells are abnormal in multiple myeloma.	17344918
Monoclonal Gammopathy of Undetermined Significance, Gammopathy, Multiple Myeloma	Stem Cell Exhaustion	To address this hypothesis in multiple myeloma (MM), we studied bone marrow mesenchymal stem cells (BMMSCs), the only long-lived cells of the bone marrow microenvironment, by gene expression profiling and phenotypic and functional studies in three groups of individuals: patients with MM, patients with monoclonal gamopathy of undefined significance (MGUS) and healthy age-matched subjects.	17344918
Carcinogenesis	Stem Cell Exhaustion	Recent studies have also suggested that epigenetic deregulation in stem cells could play an important role in carcinogenesis, and new models have been suggested for the attainment of tumourigenesis and bypass of senescence.	17352843
Hollings Cancer Center	Stem Cell Exhaustion	Expression of the platelet-derived growth factor has been shown in HCC, which may derive from hepatic stem cells that express the c-kit proto-oncogene.	17359908
Hematological Disease, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Myelodysplastic syndromes are a group of hematopoietic disorders characterized by hematopoietic stem cell dysregulation and abnormalities in the immune system.	17360037
Multiple Myeloma	Stem Cell Exhaustion	In this trial of the treatment of newly diagnosed multiple myeloma, we compared a protocol that entailed a hematopoietic stem-cell autograft followed by an allograft from an HLA-identical sibling with a protocol of tandem autografts.	17360989
Multiple Myeloma	Stem Cell Exhaustion	Among patients with newly diagnosed myeloma, survival in recipients of a hematopoietic stem-cell autograft followed by a stem-cell allograft from an HLA-identical sibling is superior to that in recipients of tandem stem-cell autografts.	17360989
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The upper age limit for autologous stem cell transplantation (ASCT) in acute myeloid leukemia (AML) is increasing and peripheral blood (PB) represents the standard source of stem cell (SC).	17361983
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Age has no influence on mobilization of peripheral blood stem cells in acute myeloid leukemia.	17361983
Stem cells	Stem Cell Exhaustion	Group A AMT in the presence of stem cell loss (32 procedures), Group B AMT without stem cell loss (24 procedures) and Group C AMT for conjunctival reconstruction (18 procedures).	17362455
Myocardial Revascularization	Stem Cell Exhaustion	Therapeutic effect of stem cell transplantation (SCTx) for myocardial neovascularization has been evaluated by histological capillary density in small animals.	17363693
Myocardial Revascularization	Stem Cell Exhaustion	Synchrotron radiation coronary microangiography for morphometric and physiological evaluation of myocardial neovascularization induced by endothelial progenitor cell transplantation.	17363693
Hematologic Neoplasms, Stable chronic Graft vs Host Disease	Stem Cell Exhaustion	Serum from 39 patients subjected to allogeneic stem cell transplantation for hematologic malignancies (22 with ecGVHD and 17 without cGVHD) and 20 healthy controls was assayed for the presence of stimulatory autoantibodies to the PDGFR by incubating purified IgG with mouse-embryo fibroblasts lacking PDGFR alpha or beta chains or with the same cells expressing PDGFR alpha.	17363728
Hematologic Toxicity Attenuation	Stem Cell Exhaustion	Hematologic toxicity was common, with 33% of patients receiving autologous hematopoietic stem cell support.	17369569
Primary Myelofibrosis, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Idiopathic myelodysplastic syndrome is a disease characterized by a clonal stem cell disorder in which megacaryocitic and granulocytic lineages are mainly involved; extramedullary myeloid metaplasia is due to abnormal location of myeloid tissue in other organs than bone marrow.	17369789
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Rituximab does not compromise the mobilization and engraftment of autologous peripheral blood stem cells in diffuse-large B-cell lymphoma.	17369863
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	To investigate effects of the preautografting administration of rituximab on the mobilization and engraftment of peripheral blood stem cells (PBSC), we retrospectively analyzed the outcomes of 43 newly diagnosed diffuse-large B-cell lymphoma patients who received CHOP chemotherapy with or without rituximab as a first-line treatment before autologous PBSC transplantation (PBSCT).	17369863
Multiple Myeloma	Stem Cell Exhaustion	Impact of age and serum creatinine value on outcome after autologous blood stem cell transplantation for patients with multiple myeloma.	17369867
Kidney Failure	Stem Cell Exhaustion	High-dose chemotherapy with stem cell transplantation (SCT) is feasible for elderly patients and patients with renal insufficiency.	17369867
Fatigue	Stem Cell Exhaustion	Experience of severe fatigue in long-term survivors of stem cell transplantation.	17369868
Fatigue	Stem Cell Exhaustion	In this study, we investigated the prevalence of fatigue after completion of stem cell transplantation (SCT).	17369868
Degenerative polyarthritis	Stem Cell Exhaustion	The aim of the present study is to focus on the possibility of deriving and expanding multipotential mesenchymal stem cells (MSCs) from bone marrow samples of patients with OA by characterizing MSCs at the single cell level.	17371154
Aplastic Anemia	Stem Cell Exhaustion	Some acquired aplastic anemia (AA) results from immune-mediated destruction of hematopoietic stem cells.	17373677
Abnormal cornea morphology, Blepharitis	Stem Cell Exhaustion	This retrospective review included six patients with Demodex blepharitis who also exhibited corneal abnormalities, which led to suspicion of limbal stem cell deficiency in three cases.	17376393
Multiple Myeloma	Stem Cell Exhaustion	Thalidomide in newly diagnosed multiple myeloma: influence of thalidomide treatment on peripheral blood stem cell collection yield.	17377586
Peripheral Stem Cell Transplantation, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	In a phase III randomized, multicenter study, the German-speaking Myeloma-Multicenter Group (GMMG) and the Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON) group investigated the influence of thalidomide (Thal) on the outcome of peripheral blood stem cell (PBSC) collection in multiple myeloma (MM) before peripheral autologous blood stem cell transplantation (ABSCT).	17377586
Angioimmunoblastic Lymphadenopathy	Stem Cell Exhaustion	Prolonged survival of patients with angioimmunoblastic T-cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation: the GELTAMO experience.	17378891
yttrium-90-ibritumomab tiuxetan, Refractory Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Yttrium-90-ibritumomab tiuxetan (Zevalin) combined with high-dose BEAM chemotherapy and autologous stem cell transplantation for chemo-refractory aggressive non-Hodgkin's lymphoma.	17379063
Refractory Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	To determine the safety and outcome following standard-dose ibritumomab tiuxetan followed by BEAM high-dose chemotherapy and autologous stem cell transplantation (ASCT) in patients with chemo-refractory aggressive non-Hodgkin's lymphoma.	17379063
hematopoietic stem cell migration to bone marrow, Lymphoma	Stem Cell Exhaustion	Long-term lymphoma survivors following high-dose chemotherapy and autograft: evidence of permanent telomere shortening in myeloid cells, associated with marked reduction of bone marrow hematopoietic stem cell reservoir.	17379077
Hematologic Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Presence of human circulating progenitor cells for cancer stromal fibroblasts in the blood of lung cancer patients.	17379768
Malignant neoplasm of lung, Specialty Type - cancer	Stem Cell Exhaustion	Our results indicated that the blood in the vicinity of human lung cancer contains fibroblast progenitor cells that have the capacity to migrate into the cancer stroma and differentiate into fibroblasts having biological characteristics different from those of tissue-derived fibroblasts.	17379768
Heart failure, N-Terminal ProA-type Natriuretic Peptide Measurement	Stem Cell Exhaustion	Our analyses show that both N-terminal pro-brain natriuretic peptide (NT-proBNP) and N-terminal pro-atrial natriuretic peptide (NT-proANP) serum levels were significantly reduced in patients with established postinfarction heart failure 3 months after transcoronary progenitor cell administration.	17379833
Heart failure	Stem Cell Exhaustion	Although intracoronary administration of bone marrow-derived mononuclear progenitor cells (BMCs) may be associated with improved cardiac function in patients with chronic postinfarction heart failure, the impact on prognosis and clinical outcome of these patients is unknown.	17379833
Lung Injury, Neoplasms, Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Early tumor regression following severe lung injury after allogeneic stem cell transplantation in a patient with renal cell carcinoma.	17379996
Lung Injury, Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	We describe a 65-year-old man who had repeated lung injuries after reduced-intensity allogeneic stem cell transplantation (RIST) for renal cell carcinoma.	17379996
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation for the treatment of high-risk acute myelogenous leukemia and myelodysplastic syndrome using reduced-intensity conditioning with fludarabine and melphalan.	17382251
Hepatitis B	Stem Cell Exhaustion	Changes in serologic markers of hepatitis B following autologous hematopoietic stem cell transplantation.	17382252
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation (auto HSCT) has become the standard treatment for patients with relapsed diffuse large-cell non-Hodgkin's lymphoma (NHL) responding to conventional salvage chemotherapy.	17382255
Acute myocardial infarction	Stem Cell Exhaustion	Lack of additional benefit of intracoronary transplantation of autologous peripheral blood stem cell in patients with acute myocardial infarction.	17384447
Acute myocardial infarction	Stem Cell Exhaustion	Whether the additional intracoronary transplantation of autologous peripheral blood stem cells (PBSC), which were mobilized by granulocyte-colony-stimulating factor (G-CSF), could safely improve myocardial function in patients with acute myocardial infarction (AMI) was investigated.	17384447
Graft-vs-Host Disease	Stem Cell Exhaustion	Here we investigated the influence of parameters known before hematopoietic stem cell transplantation (HSCT) as well as the relevance of graft-versus-host disease (GvHD) and cytomegalovirus (CMV) reactivation on post transplant lymphocyte reconstitution in 148 patients treated in our institution between 1996 and 2003.	17384658
B-Cell Lymphomas, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	A prospective, multicenter, nonrandomized phase 2 trial was conducted to evaluate the efficacy and safety of a single dose of yttrium-90 ((90)Y) ibritumomab tiuxetan in elderly patients in first relapsed or primary refractory diffuse large B-cell lymphoma (DLBCL) ineligible for stem-cell transplantation.	17387223
Peripheral Arterial Diseases	Stem Cell Exhaustion	Effect of acute exercise on endothelial progenitor cells in patients with peripheral arterial disease.	17390544
Peripheral Vascular Diseases, Peripheral Arterial Diseases	Stem Cell Exhaustion	To determine whether exercise increases endothelial progenitor cells (EPCs) in patients with peripheral vascular disease, we developed a multi-parameter flow cytometry assay to rigorously assess EPCs and mature endothelial cells (ECs) in control subjects and patients with peripheral artery disease (PAD) subjected to graded exercise.	17390544
Graft-vs-Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic graft-versus-host disease (GVHD) remains the major cause of late morbidity and mortality after allogeneic stem cell transplantation.	17391494
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Interleukin-1 alpha genotype and outcome of unrelated donor haematopoietic stem cell transplantation for chronic myeloid leukaemia.	17391495
Graft-vs-Host Disease	Stem Cell Exhaustion	Sirolimus-based graft-versus-host disease prophylaxis protects against cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation: a cohort analysis.	17392502
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Bone marrow stem-cell administration in patients with myocardial infarction improved myocardial performance and in some studies contributed to favorable left ventricular remodeling.	17394248
Cardiomyopathies	Stem Cell Exhaustion	The long-term effect of intracoronary infusion of progenitor cells in patients with chronic ischemic cardiomyopathy.	17394248
Hematologic Neoplasms, Aspergillosis	Stem Cell Exhaustion	Caspofungin as salvage monotherapy for invasive aspergillosis in patients with haematological malignancies or following allogeneic stem cell transplantation: efficacy and concomitant cyclosporin A. Caspofungin (CAS) has shown efficacy as salvage monotherapy for invasive aspergillosis (IA) in two open label non-comparative trials.	17394607
Hematologic Neoplasms	Stem Cell Exhaustion	We retrospectively reviewed the charts of all patients with haematological malignancies or postallogeneic haematopoietic stem cell transplant (HSCT) who received >/=1 dose of CAS as salvage monotherapy for IA as part of the Australian Special Access Scheme (4/2001-8/2002).	17394607
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Complete remission and early relapse of refractory plasma cell leukemia after bortezomib induction and consolidation by HLA-mismatched unrelated allogeneic stem cell transplantation.	17396042
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Experiences with bortezomib in plasma cell leukemia prior to allogeneic stem cell transplantation (SCT) have not yet been reported.	17396042
Encephalitis	Stem Cell Exhaustion	Human herpesvirus-6 encephalitis following allogeneic hematopoietic stem cell transplantation.	17401392
Graft-vs-Host Disease, Virus Diseases	Stem Cell Exhaustion	Immunosuppressive monoclonal antibodies directed to immune system cells may reduce rejection and graft versus host disease (GvHD) after allogeneic stem cell transplantation (SCT), but can increase the risks of viral infection.	17401392
Intrahepatic Cholangiocarcinoma, Specialty Type - cancer	Stem Cell Exhaustion	A case of an alpha-fetoprotein-producing intrahepatic cholangiocarcinoma suggests probable cancer stem cell origin.	17405896
Specialty Type - cancer	Stem Cell Exhaustion	In addition, cancer cells showed partially positive reaction to anti-CK14, a liver stem cell marker, and to anticluster designation (CD) 133, a hematopoietic stem cell marker, and negative reaction to antihepatocyte paraffin (HepPar) 1.	17405896
Neoplasms	Stem Cell Exhaustion	These data may indicate that the tumor was derived from a normal liver stem cell that underwent oncogenic transformation.	17405896
Specialty Type - cancer, Malignant Neoplasms, Carcinogenesis	Stem Cell Exhaustion	Recent evidence suggests that some cancers may originate from cancer stem cells, which may derive from carcinogenesis of normal stem cells.	17405896
Hepatitis B, Chronic, Intrahepatic Cholangiocarcinoma, Liver neoplasms	Stem Cell Exhaustion	We report here a case of an alpha-fetoprotein (AFP)-producing intrahepatic cholangiocarcinoma (ICC) in an 81-year-old woman with chronic hepatitis C viral infection, suggesting malignant transformation of hepatic stem cells as a mechanism for hepatic neoplasia.	17405896
Malignant Neoplasms	Stem Cell Exhaustion	A hepatic progenitor cell population, which gives rise to hepatocytes and cholangiocytes, has been suggested in humans, though whether these cells can give rise to malignant tumors has not been confirmed.	17405896
Small cell carcinoma of lung	Stem Cell Exhaustion	Standard versus dose-intensified chemotherapy with sequential reinfusion of hematopoietic progenitor cells in small cell lung cancer patients with favorable prognosis.	17410010
Tissue damage	Stem Cell Exhaustion	Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells.	17415234
Autoimmune hemolytic anemia	Stem Cell Exhaustion	Immune-mediated hemolytic anemia is a well-recognized complication of hematopoietic stem cell transplantation.	17417790
Immunohematological	Stem Cell Exhaustion	After one course of Campath-1H his hematologic parameters normalized, suggesting that the compound may be an effective therapy for complex immunohematologic disorders complicating hematopoietic stem cell transplantation.	17417790
Hematologic Neoplasms	Stem Cell Exhaustion	We present 10 patients with haematological malignancies who underwent an allogeneic stem cell transplant and developed sclerodermatous GVHD.	17419693
Osteosclerosis, Fibrosis Assessment, Primary Myelofibrosis	Stem Cell Exhaustion	Myelofibrosis with myeloid metaplasia (MMM) is a clonal disorder of the haematopoietic stem cell which can be associated with marrow fibrosis and/or osteosclerosis.	17419743
Diabetes Mellitus, Insulin-Dependent	Stem Cell Exhaustion	Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus.	17426276
Intestinal Perforation, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Pneumatosis intestinalis with pneumoperitoneum mimicking intestinal perforation in a patient with myelodysplastic syndrome after hematopoietic stem cell transplantation.	17427646
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We describe a 35-year-old man who undertook hematopoietic stem cell transplantation due to myelodysplastic syndrome.	17427646
Chronic lymphoproliferative disease NOS	Stem Cell Exhaustion	The authors analyzed the intensity of the CD52 antigen expression in patients with chronic lymphoproliferative diseases and compared them with B-lymphocytes of a healthy population and CD34(+) cells in peripheral blood stem cells (PBSC) grafts.	17428002
Vascular System Injuries	Stem Cell Exhaustion	This feature could be the direct consequence of an augmented request of stem cells to respond to the most important endothelial impairment but could also show a defective capacity of EPCs to home in and repair the sites of vascular injury.	17429198
Arthritis, Cryoglobulinemia	Stem Cell Exhaustion	Development of acute inflammatory arthritis by granulocyte-macrophage colony-stimulating factor during autologous stem cell transplantation for cryoglobulinemia.	17429637
Arthritis, Cryoglobulinemia	Stem Cell Exhaustion	We describe a 53-year-old male who developed acute inflammatory arthritis by granulocyte-macrophage colony-stimulating factor (GM-CSF) following autologous stem cell transplantation for cryoglobulinemia.	17429637
Trauma	Stem Cell Exhaustion	Number and proliferative capacity of human mesenchymal stem cells are modulated positively in multiple trauma patients and negatively in atrophic nonunions.	17431529
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GVHD) is a T cell-mediated disease seen most commonly after hematopoietic stem cell transplantation.	17433850
Malignant Thymoma	Stem Cell Exhaustion	Specifically, thymoma-associated multiorgan autoimmunity is defined as a disease of the liver, intestine, or skin, which on histopathology resembles GVHD but is seen in the setting of malignant thymoma and not after hematopoietic stem cell transplantation.	17433850
Bacteremia	Stem Cell Exhaustion	Epidemiology of bacteremia and factors associated with multi-drug-resistant gram-negative bacteremia in hematopoietic stem cell transplant recipients.	17438585
Bacteremia	Stem Cell Exhaustion	The incidence of Gram-negative bacteremia has increased in hematopoietic stem cell transplant (HSCT) recipients.	17438585
Cessation of life, Toxic effect	Stem Cell Exhaustion	Reasons for not undergoing the second autologous transplant were death (n=2 patients), insufficient peripheral blood stem cells (n=8 patients), severe transplant-related toxicity (n=10 patients), allotransplants (n=9 patients), early progression after first transplant (n=6 patients), lost to follow-up (n=3 patients), and patient refusal (n=19 patients).	17440982
Hepatic Veno-Occlusive Disease, Allogeneic Hematopoietic Stem Cell Transplantation	Stem Cell Exhaustion	[Low dose heparin for the prevention of hepatic veno-occlusive disease after allogeneic hematopoietic stem cell transplantation].	17445443
Hepatic Veno-Occlusive Disease, Venoocclusive disease	Stem Cell Exhaustion	To explore the safety and efficacy of low dose heparin for the prevention of hepatic veno-occlusive disease (VOD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) conditioned with busulfan and cyclophosphamide (BU-CY2) and the ideal time frame of the heparin administration.	17445443
Fracture, Osteopenia	Stem Cell Exhaustion	Increased risk of bone loss without fracture risk in long-term survivors after allogeneic stem cell transplantation.	17448910
Multiple Myeloma	Stem Cell Exhaustion	Results of a retrospective single institution analysis of targeted skeletal radiotherapy with (166)Holmium-DOTMP as conditioning regimen for autologous stem cell transplant for patients with multiple myeloma.	17448913
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Phase I/II trials showed feasibility and tolerability when combined with high-dose melphalan with or without total-body irradiation (TBI) in patients with multiple myeloma (MM) undergoing autologous stem cell transplantation (ASCT).	17448913
Communicable Diseases	Stem Cell Exhaustion	Cytomegalovirus (CMV) infection is a major complication after allogeneic hematopoietic stem cell transplantation (Allo-HSCT); however, we have little information on the clinical features of CMV reactivation after cord blood transplantation using reduced-intensity regimens (RI-CBT) for adults.	17448917
Hodgkin Disease	Stem Cell Exhaustion	Tandem autologous stem cell transplantation for patients with primary refractory or poor risk recurrent Hodgkin lymphoma.	17448919
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	Although autologous stem cell transplantation (ASCT) for patients with relapsed/refractory Hodgkin lymphoma (HL) appears to offer a survival advantage over conventional therapy, only approximately 25% to 35% of patients with primary progressive or poor-risk recurrent HL can achieve durable remission after ASCT, with disease progressive after transplant accounting for most of the treatment failures.	17448919
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Equivalent survival for sibling and unrelated donor allogeneic stem cell transplantation for acute myelogenous leukemia.	17448920
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Recent studies have shown comparable survival outcomes for unrelated donor (URD) stem cell transplantation in chronic myelogenous leukemia compared to sibling donors.	17448920
Vancomycin-Resistant Enterococci, Colonization, Infection of bloodstream	Stem Cell Exhaustion	Colonization, bloodstream infection, and mortality caused by vancomycin-resistant enterococcus early after allogeneic hematopoietic stem cell transplant.	17448922
Vancomycin-Resistant Enterococci, Infection of bloodstream	Stem Cell Exhaustion	Bloodstream infection caused by vancomycin-resistant enterococcus (VRE) is associated with very high mortality among allogeneic hematopoietic stem cell transplant (alloHSCT) recipients.	17448922
Hematologic Neoplasms	Stem Cell Exhaustion	Allogeneic stem cell transplantation for patients with advanced hematological malignancies: comparison of fludarabine-based reduced intensity conditioning versus myeloablative conditioning.	17449929
Hematologic Neoplasms	Stem Cell Exhaustion	We compared the outcomes of allogeneic hematopoietic stem cell transplantation using reduced intensity and myeloablative conditioning for the treatment of patients with advanced hematological malignancies.	17449929
Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy followed by autologous blood stem cell transplantation is the standard treatment for myeloma patients.	17450182
Multiple Myeloma	Stem Cell Exhaustion	Efficient mobilization of peripheral blood stem cells following CAD chemotherapy and a single dose of pegylated G-CSF in patients with multiple myeloma.	17450182
Polycythemia Vera	Stem Cell Exhaustion	JAK2 617V>F positive polycythemia rubra vera maintained by approximately 18 stochastic stem-cell divisions per year, explaining age of onset by a single rate-limiting mutation.	17452518
Malignant Neoplasms	Stem Cell Exhaustion	Conversely, the peak incidences of most cancers are similar to stem-cell mutation rates at single loci, implying only one rate-limiting mutation.	17452518
Polycythemia Vera, Malignant Neoplasms	Stem Cell Exhaustion	Here, flow cytometrically measured red blood cells mutated at a selectively neutral locus, glycophorin A, allow observation of individual stem-cell differentiation events in a log-log malignancy, polycythemia rubra vera.	17452518
Acute GVH disease	Stem Cell Exhaustion	Regulatory T-cells in the graft and the risk of acute graft-versus-host disease after allogeneic stem cell transplantation.	17452902
Graft-vs-Host Disease	Stem Cell Exhaustion	FOXP3+ regulatory T-cells (Treg) are important regulators of allo-reactivity and may therefore represent an important predictor for the risk of graft versus-host disease (GVHD) after allogeneic stem cell transplantation.	17452902
Anaplastic carcinoma, Malignant neoplasm of thyroid	Stem Cell Exhaustion	These findings raise a question about the classical model of anaplastic transformation and suggest some roles of thyroid cancer stem cells in the generation of anaplastic carcinoma.	17453004
Multiple Myeloma	Stem Cell Exhaustion	The aim of the study was to evaluate whether adequate stem cells (CD34+) could be harvested at presentation in myeloma patients such that high dose melphalan (HDM) with autologous stem cell rescue can be offered as primary therapy.	17454191
Multiple Myeloma	Stem Cell Exhaustion	Collection of peripheral blood stem cells in new patients with myeloma receiving minimal or no prior cytoreductive therapy.	17454191
Multiple Myeloma	Stem Cell Exhaustion	We conclude that it is possible to collect stem cells from myeloma patients at presentation with minimal prior therapy.	17454191
Multiple Myeloma	Stem Cell Exhaustion	We performed a retrospective analysis in 54 patients with multiple myeloma undergoing high-dose melphalan chemotherapy + autologous peripheral blood stem cell transplantation to better define the value of routine control of CD4+ T lymphocyte counts in this important patient group.	17454590
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Phase I trial of (90)Y-ibritumomab tiuxetan in patients with relapsed B-cell non-Hodgkin's lymphoma following high-dose chemotherapy and autologous stem cell transplantation.	17454625
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Between January 2001 and September 2005, 19 patients with progressive B-cell non-Hodgkin's lymphoma were treated with a cohort-specific dose of yttrium-90 ibritumomab tiuxetan (0.10 - 0.20 mCi/kg) to determine appropriate dosing in patients who had previously received high-dose chemotherapy and autologous stem cell transplantation (ASCT).	17454625
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Fifty-three patients with multiple myeloma (MM) underwent an allogeneic stem cell transplant (HSCT) from their HLA identical siblings using a reduced-intensity conditioning consisting of thioteopa 5 mg/kg, fludarabine 90 mg/m(2), and melphalan 80 mg/m(2).	17454635
Subarachnoid Hemorrhage	Stem Cell Exhaustion	Activation of endogenous neural stem cells in the adult human brain following subarachnoid hemorrhage.	17455304
ACSM3 gene, Subarachnoid Hemorrhage, Aneurysm, Ruptured	Stem Cell Exhaustion	In the present report, we describe neural progenitor cell proliferation in the brain of patients suffering from subarachnoid hemorrhage (SAH) resulting from ruptured aneurysm.	17455304
Subarachnoid Hemorrhage	Stem Cell Exhaustion	Thus, activation of neural progenitor cell proliferation may occur in adult human brain following subarachnoid hemorrhage, possibly contributing to the promotion of spontaneous recovery, in this pathological condition.	17455304
ACSM3 gene	Stem Cell Exhaustion	In tissue specimens from SAH patients, RT-PCR and IHC revealed the expression of a variety of markers consistent with CNS progenitor cells, including nestin, vimentin, SOX-2, and Musashi1 and -2.	17455304
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	This study evaluated the efficacy of non-myeloablative allogeneic stem cell transplantation in patients with advanced CLL and assessed the impact of ZAP-70 expression on the outcome.	17456058
Liver carcinoma, Hollings Cancer Center, Carcinogenesis	Stem Cell Exhaustion	In this study, we examined the possible involvement of progenitor cells in the carcinogenesis of human hepatocellular carcinoma (HCC) using tissue specimens and cell lines.	17456779
Limbal stem cell deficiency	Stem Cell Exhaustion	To study the potential use of human anterior lens capsule as a scaffold for stem cell transplantation in treatment of limbal cell deficiency.	17457198
Coronary Stenosis, Coronary Arteriosclerosis	Stem Cell Exhaustion	Circulating endothelial progenitor cells, C-reactive protein and severity of coronary stenosis in Chinese patients with coronary artery disease.	17460383
Coronary Stenosis, Coronary Arteriosclerosis	Stem Cell Exhaustion	We sought to investigate whether numbers and activity of circulating endothelial progenitor cells (EPCs) correlate with severity of coronary stenosis as well as cardiovascular risk factors in patients with stable coronary artery disease (CAD).	17460383
Cytomegalovirus Infections	Stem Cell Exhaustion	Oral valganciclovir as preemptive therapy for cytomegalovirus infection post allogeneic stem cell transplantation.	17461994
Neutropenia, Fusariosis	Stem Cell Exhaustion	Successful treatment of disseminated fusariosis with posaconazole during neutropenia and subsequent allogeneic hematopoietic stem cell transplantation.	17462004
Infarction	Stem Cell Exhaustion	Interestingly, a large number of neural stem cells, vascular endothelial growth factor-immunopositive cells and new blood vessels were observed only around the region of infarction, and none in the corresponding brain areas of the healthy control.	17465777
Polycythemia Vera, Primary Myelofibrosis, Hyperplasia	Stem Cell Exhaustion	In order to investigate the biologic processes underlying and resulting from the megakaryocytic hyperplasia that characterizes idiopathic myelofibrosis (IMF), peripheral blood CD34+ cells isolated from patients with IMF, polycythemia vera (PV), and G-CSF-mobilized healthy volunteers were cultured in the presence of stem cell factor and thrombopoietin.	17473062
Pulmonary Complication, Idiopathic Pulmonary Fibrosis, Connective Tissue Diseases	Stem Cell Exhaustion	Other causes were noninfectious pulmonary complications of hematopoietic stem-cell or solid-organ transplantation (17%), connective tissue diseases (16%), acute exacerbation of idiopathic pulmonary fibrosis (12%), drugs (10%), and radiation therapy (2%).	17475632
Acquired aplastic anemia, Chronic graft-versus-host disease	Stem Cell Exhaustion	Worse outcome and more chronic GVHD with peripheral blood progenitor cells than bone marrow in HLA-matched sibling donor transplants for young patients with severe acquired aplastic anemia.	17475907
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Aldehyde dehydrogenase (ALDH) activity is used to define normal hematopoietic stem cell (HSC), but its link to leukemic stem cells (LSC) in acute myeloid leukemia (AML) is currently unknown.	17476279
Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy with autologous stem cell support is an effective treatment in advanced multiple myeloma.	17476507
Toxic effect, Neoplasms, Multiple Myeloma	Stem Cell Exhaustion	In this study, we compare chemotherapy with ifosfamide, epirubicin, and etoposide (IEV) or cyclophosphamide and etoposide (CE) in 47 patients with multiple myeloma with regard to stem cell mobilization, toxicity, and tumor response.	17476507
Toxic effect, Neoplasms	Stem Cell Exhaustion	In summary, both treatment protocols can readily be used for the mobilization of peripheral blood stem cells with comparable major toxicities and similar tumor response rates.	17476507
Lymphoproliferative Disorders	Stem Cell Exhaustion	Epstein-Barr virus-associated post-transplant lymphoproliferative disorder presenting with skin involvement after CD34-selected autologous peripheral blood stem cell transplantation.	17478388
Post-transplant lymphoproliferative disorder, Lymphoproliferative Disorders	Stem Cell Exhaustion	We report a case of Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disorder (PTLD) after CD34-selected autologous peripheral blood stem cell transplantation (PBSCT).	17478388
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Selective depletion (SD) of host-reactive donor T cells from allogeneic stem-cell transplants (SCTs) using an anti-CD25 immunotoxin (IT) is a strategy to prevent acute graft-versus-host disease (aGvHD).	17478639
Acute lymphocytic leukemia, herpesvirus 3, human, BCR gene, Communicable Diseases	Stem Cell Exhaustion	We describe a patient with acute lymphocytic leukemia (ALL) who developed visceral varicella-zoster virus (VZV) infection following cord blood stem cell transplantation (CBSCT) and was successfully treated with intravenous acyclovir (ACV).	17483062
Primary cardiac lymphoma	Stem Cell Exhaustion	Successful treatment of primary cardiac lymphoma by rituximab-CHOP and high-dose chemotherapy with autologous peripheral blood stem cell transplantation.	17483065
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are a group of heterogeneous hematopoietic stem cell disorders characterized by ineffective hematopoiesis and by a high risk of evolution into acute myelogenous leukemia (AML).	17483341
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We describe a 14-year-old with myelodysplastic syndrome treated with subcutaneous 5-azacitidine for disease relapse 2 years after hematopoietic stem cell transplant.	17483713
Diffuse alveolar hemorrhage	Stem Cell Exhaustion	Outcome of alveolar hemorrhage in hematopoietic stem cell transplant recipients.	17483846
Diffuse alveolar hemorrhage	Stem Cell Exhaustion	Alveolar hemorrhage (AH) is a frequent, serious complication of hematopoietic stem cell transplantation (HSCT).	17483846
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	The histological location of hTERT in these tumors has been discussed in the context of the cancer stem cell theory.	17487355
Peripheral Blood Stem Cells	Stem Cell Exhaustion	It is routinely used in combination with the monoclonal anti-CD20 antibody rituximab (R-DHAP), particularly for peripheral blood stem cell (PBSC) mobilization.	17487733
Lymphoma	Stem Cell Exhaustion	Mobilization of peripheral blood progenitor cells after DHAP regimen with or without rituximab: a large multicenter comparative study in patients with malignant lymphoma.	17487733
Osteopenia, Hyperparathyroidism	Stem Cell Exhaustion	Loss of bone mineral density and secondary hyperparathyroidism are complications of autologous stem cell transplantation.	17487736
Multiple Myeloma	Stem Cell Exhaustion	High dose therapy with autologous stem cell transplantation (HDT-ASCT) has prolonged survival in patients with multiple myeloma.	17488336
Lymphoma	Stem Cell Exhaustion	Characterization and clinical relevance of circulating and biopsy-derived endothelial progenitor cells in lymphoma patients.	17488657
Neoplasms	Stem Cell Exhaustion	Endothelial progenitor cells (EPC) have been proven to be essential for tumor angiogenesis and growth in animal tumor models.	17488657
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Effect of histone deacetylase inhibitor valproic acid on progenitor cells of acute myeloid leukemia.	17488665
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Our data suggest a differential effect of VPA on the small population of AML progenitor cells and the bulk of aberrantly differentiated blasts in the majority of AML samples tested.	17488665
Bronchiolitis Obliterans, Pneumonia	Stem Cell Exhaustion	T-cell depletion prevents from bronchiolitis obliterans and bronchiolitis obliterans with organizing pneumonia after allogeneic hematopoietic stem cell transplantation with related donors.	17488669
Bronchiolitis Obliterans, bottle - unit dose, Bronchiolitis Obliterans Organizing Pneumonia, Pneumonia	Stem Cell Exhaustion	Bronchiolitis obliterans (BO) and bronchiolitis obliterans organizing pneumonia (BOOP) are late-onset non-infectious pulmonary complications (LONIPCs) following allogeneic hematopoietic stem cell transplantation (HSCT).	17488669
Bronchiolitis Obliterans Organizing Pneumonia	Stem Cell Exhaustion	In the present study 10 of 197 conventionally prepared stem cell recipients developed BOOP after 365 days and 6 patients developed BO 333 days post-transplant.	17488669
Lymphoma	Stem Cell Exhaustion	Long-term outcomes after reduced-intensity conditioning allogeneic stem cell transplantation for low-grade lymphoma: a survey by the French Society of Bone Marrow Graft Transplantation and Cellular Therapy (SFGM-TC).	17488686
Transplant-Related Malignant Neoplasm, Lymphoma	Stem Cell Exhaustion	High-dose chemotherapy with allogeneic stem cell transplantation (SCT) has proven to be a successful treatment for low-grade lymphoma (LGL), but is associated with considerable transplant-related mortality (TRM).	17488686
Malignant Neoplasms, Aplastic Anemia	Stem Cell Exhaustion	Patients (n=152) with a malignancy or aplastic anemia underwent allogeneic stem cell transplantation at a single institute.	17488689
Infection	Stem Cell Exhaustion	We conclude that the A1513C polymorphism in the P2X7R gene is related to the occurrence of infections and survival after allogeneic stem cell transplantation.	17488689
Abnormality of the vasculature, Microvascular Angina, Endothelial dysfunction	Stem Cell Exhaustion	Vascular endothelial function and circulating endothelial progenitor cells in patients with cardiac syndrome X. Endothelial dysfunction and microvascular abnormalities have been reported in patients with cardiac syndrome X (CSX), but the underlying mechanisms are unclear.	17488770
BCR-ABL Fusion Gene	Stem Cell Exhaustion	While out of 2 patients who underwent haemopoietic stem cell transplantation (HSCT), one patient with higher level of TREC before transplantation was confirmed to express undetectable level of TREC by three consecutive detections after transplantation, other one patient was identified to express low level of bcr-abl.	17490540
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	In 26 CML patients received allogeneic peripheral blood stem cell transplantation (allo-PBSCT) and 4 CML patients treated with imatinib, the expression of bcr-abl mRNA and DNA-PKcs protein was detected by RT-PCR and Western blot, respectively.	17493325
Lymphoma	Stem Cell Exhaustion	High-dose therapy (HDT) with stem-cell support is the reference treatment for relapsed lymphoma, but is not appropriate for all patients.	17496309
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	The antibody alemtuzumab (anti-CD52) is effective in preventing acute graft-versus-host disease (GvHD) after allogeneic hematopoietic stem cell transplantation (aHSCT).	17496545
Recurrent Childhood Hodgkin Lymphoma, LIPC gene	Stem Cell Exhaustion	The objective was to determine the prognostic value of functional imaging (FI) in predicting outcome of patients with recurrent/refractory Hodgkin lymphoma (HL) before undergoing high-dose chemotherapy with autologous stem cell transplantation (ASCT).	17497648
Prostatic Intraepithelial Neoplasias, Prostate carcinoma	Stem Cell Exhaustion	Prostate stem cell antigen (PSCA) mRNA expression in prostatic intraepithelial neoplasia: implications for the development of prostate cancer.	17503471
Prostatic Intraepithelial Neoplasias	Stem Cell Exhaustion	Prior data clearly demonstrated the expression of prostate stem cell antigen (PSCA) mRNA in prostatic intraepithelial neoplasia (PIN) tissues.	17503471
Glioma	Stem Cell Exhaustion	Increased levels of circulating endothelial progenitor cells and circulating endothelial nitric oxide synthase in patients with gliomas.	17503506
Glioma	Stem Cell Exhaustion	We hypothesized that patients with gliomas have increased levels of circulating endothelial progenitor cells (EPCs) and circulating endothelial nitric oxide synthase (eNOS).	17503506
Graft-vs-Host Disease	Stem Cell Exhaustion	Recently, high numbers of regulatory T cells within the stem cell graft were described to be associated with less graft-versus-host disease (GVHD) after related peripheral blood stem cell transplantation (PBSCT).	17504991
Aplastic Anemia	Stem Cell Exhaustion	A bone marrow aspiration and biopsy done showed a gross hypocellular bone marrow with very few erythriod and myeloid cells and no suggestion of progenitor cells, consistent with aplastic anemia.	17505778
Graft failure, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Normal hematopoietic function and multiple bone marrow clonal abnormalities in a patient with acute myeloid leukemia after two mismatched stem-cell transplants with graft failure and autologous reconstitution.	17506066
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 13-year-old male with primary refractory acute myelogenous leukemia (AML-M0), underwent two mismatched stem cell transplantations (SCT) and experienced graft failure after both procedures.	17506066
Myeloproliferative disease, Eosinophil count raised (finding)	Stem Cell Exhaustion	Hypereosinophilia can result from the presence of a defect in the hematopoietic stem cell giving rise to eosinophilia, it can be present in many myeloproliferative disorders or alternatively it may be a reactive form, secondary to many clinical conditions.	17508006
Neurotoxicity Syndromes, Cerebral Arterial Diseases	Stem Cell Exhaustion	Neurotoxicity upon infusion of dimethylsulfoxide-cryopreserved peripheral blood stem cells in patients with and without pre-existing cerebral disease.	17509106
Toxic effect	Stem Cell Exhaustion	Toxicity related to the infusion of dimethylsulfoxide (DMSO)-cryopreserved peripheral blood stem cells (DMSO-PBSC) mainly comprises cardiovascular events.	17509106
Antilymphocyte Serum	Stem Cell Exhaustion	Intrathecal application of neuroectodermally converted stem cells into a mouse model of ALS: limited intraparenchymal migration and survival narrows therapeutic effects.	17510731
Antilymphocyte Serum	Stem Cell Exhaustion	Further experiments defining the optimal cell dose, time point and route of application and particularly strategies to improve the homing of transplanted cells towards the CNS region of interest are warranted to define the therapeutic potential of mesodermal stem cells for the treatment of ALS.	17510731
Amyotrophic Lateral Sclerosis, Antilymphocyte Serum	Stem Cell Exhaustion	Stem and progenitor cells provide a promising therapeutic strategy for amyotrophic lateral sclerosis (ALS).	17510731
Cytomegalovirus Retinitis	Stem Cell Exhaustion	In order to describe the clinical characteristics and outcomes of CMV retinitis after hematopoietic stem cell and solid organ transplantation, we performed a retrospective review of all cases of CMV retinitis at the Mayo Clinic (Rochester, Minnesota) during 1990-2004.	17511815
Cytomegalovirus Retinitis	Stem Cell Exhaustion	During this 15-year period, CMV retinitis was diagnosed in 14 eyes of 9 patients who had received kidney (n=5), liver (n=2), heart (n=1), and autologous hematopoietic stem cell transplant (n=1).	17511815
Mycoses	Stem Cell Exhaustion	Invasive fungal infections in allogeneic and autologous stem cell transplant recipients: a single-center study of 166 transplanted patients.	17511828
Intraoperative floppy iris syndrome, Mycoses	Stem Cell Exhaustion	Invasive fungal infections (IFIs) remain a major cause of infection-related morbidity and mortality following hematopoietic stem cell transplantation (HSCT).	17511828
Multiple Myeloma	Stem Cell Exhaustion	This study examines the response to dexamethasone-doxorubicin-vincristine (DAV) therapy, followed by conditioning regimen and autologous stem cells transplantation (ASCT) in patients with multiple myeloma in relation with the presence of polymorphisms in genes involved in drug metabolism (GSTP1) and DNA synthesis (TYMS).	17512053
Glioblastoma	Stem Cell Exhaustion	Organotypic distribution of stem cell markers in formalin-fixed brain harboring glioblastoma multiforme.	17516028
Glioblastoma	Stem Cell Exhaustion	To explore this hypothesis, we examined the distribution of two stem cell markers, activating transcription factor 5 (ATF5) and CD133, in an autopsy brain specimen from an individual with glioblastoma multiforme.	17516028
Brain Injuries, Neoplasms	Stem Cell Exhaustion	The robust staining for ATF5 and CD133 in histologically normal ventricular zone suggests that an increase in periventricular stem cell activity occurred in this patient on the side of the tumor, either as a localized response to brain injury or as an integral component of oncogenesis and tumor recurrence.	17516028
Glioblastoma	Stem Cell Exhaustion	The role of stem cells in the origin, growth patterns, and infiltration of glioblastoma multiforme is a subject of intense investigation.	17516028
Adult Glioblastoma	Stem Cell Exhaustion	One possibility is that glioblastoma may arise from transformed stem cells in the ventricular zone.	17516028
Multiple Myeloma	Stem Cell Exhaustion	Single-centre experience with nonmyeloablative allogeneic stem cell transplantation in patients with multiple myeloma: prolonged remissions induced.	17519513
Multiple Myeloma	Stem Cell Exhaustion	The role of allogeneic stem cell transplantation in multiple myeloma is not yet established.	17519513
Multiple Myeloma	Stem Cell Exhaustion	We retrospectively evaluated the outcome of nonmyeloablative allogeneic stem cell transplantation (NMA) in patients with multiple myeloma treated at the Department of Haematology of the University Medical Centre Utrecht.	17519513
Blood Vessel, Ischemia	Stem Cell Exhaustion	Recent studies have shown that in response to vascular damage or ischemia, bone marrow-derived endothelial progenitor cells (EPCs) are recruited into the circulation.	17521243
septic	Stem Cell Exhaustion	Increased circulating endothelial progenitor cells in septic patients: correlation with survival.	17522579
septic	Stem Cell Exhaustion	Thus, recruitment of circulating endothelial progenitor cells (cEPCs) to these lesions might have a beneficial effect on the clinical course in septic patients.	17522579
Hematologic Neoplasms	Stem Cell Exhaustion	The first 2 years of clinical experience with peripheral blood stem cell transplantation for various hematological malignancies: results from a single Baskent University Center.	17524948
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation is the current standard approach for patients with multiple myeloma and relapsed or refractory lymphoma.	17524948
ISS Stage III Plasma Cell Myeloma	Stem Cell Exhaustion	Seven evaluable patients younger than 65 years old with stage II/III multiple myeloma were treated with high-dose melphalan therapy (140 mg/m(2)) plus autologous peripheral blood stem cell transplantation.	17524948
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Four patients with acute myeloblastic leukemia underwent nonmyeloablative allogeneic peripheral stem cell transplantation.	17524948
Polyendocrinopathies, Autoimmune	Stem Cell Exhaustion	Resolution of autoimmune polyglandular syndrome-associated keratopathy with keratolimbal stem cell transplantation: case report and historical literature review.	17525667
Keratopathy	Stem Cell Exhaustion	A 23-year-old man with decreased vision secondary to APS1-associated keratopathy was treated with systemic immunosuppression and keratolimbal allograft (KLAL) stem cell transplantation.	17525667
Keratopathy	Stem Cell Exhaustion	An underlying etiology of APS1-associated keratopathy is stem cell deficiency, which can be treated effectively with KLAL and systemic immunosuppression.	17525667
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Aberrant marker expression patterns on the CD34+CD38- stem cell compartment in acute myeloid leukemia allows to distinguish the malignant from the normal stem cell compartment both at diagnosis and in remission.	17525725
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukemia (AML) is generally regarded as a stem cell disease.	17525725
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In CD34-positive AML, the leukemic stem cell has been recognized as CD38 negative.	17525725
Systemic Scleroderma	Stem Cell Exhaustion	Long-term follow-up results after autologous haematopoietic stem cell transplantation for severe systemic sclerosis.	17526554
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation in peripheral T-cell lymphoma using a uniform high-dose regimen.	17530000
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	The role of high-dose therapy and autologous stem cell transplantation (ASCT) for patients with peripheral T-cell lymphoma (PTCL) is poorly defined.	17530000
Ki-1+ Anaplastic Large Cell Lymphoma	Stem Cell Exhaustion	Thirty-two patients with PTCL-unspecified (PTCL-u; 11 patients) and anaplastic large-cell lymphoma (21 patients) underwent autologous stem cell transplant, mostly for relapsed or refractory disease.	17530000
Lymphoma	Stem Cell Exhaustion	Difficult stem cell mobilization despite adequate CD34+ cell dose predicts shortened progression free and overall survival after autologous HSCT for lymphoma.	17530003
Cytomegalovirus Infections	Stem Cell Exhaustion	Comparable incidence and severity of cytomegalovirus infections following T cell-depleted allogeneic stem cell transplantation preceded by reduced intensity or myeloablative conditioning.	17530007
Pregnancy Complications, Infectious	Stem Cell Exhaustion	Reports on infectious complications following reduced intensity conditioning (RIC) before allogeneic stem cell transplantation (allo-SCT) are equivocal.	17530007
Hematologic Neoplasms	Stem Cell Exhaustion	Risk factors associated with late cytomegalovirus reactivation after allogeneic stem cell transplantation for hematological malignancies.	17530009
Hematologic Neoplasms	Stem Cell Exhaustion	We analyzed the clinical factors associated with late cytomegalovirus (CMV) reactivation in a group of 269 consecutive recipients of allogeneic stem cell transplant (SCT) for hematological malignancies.	17530009
Systemic Scleroderma	Stem Cell Exhaustion	Impairment of endothelial cell differentiation from bone marrow-derived mesenchymal stem cells: new insight into the pathogenesis of systemic sclerosis.	17530639
Blood Vessel, Sample Size Calculation	Stem Cell Exhaustion	The possibility that endothelial progenitor cells could be used to increase vessel growth in chronic ischemic tissues may open up new avenues in the treatment of vascular damage caused by SSc.	17530639
T-Cell Lymphoma	Stem Cell Exhaustion	Disappointing outcome of autologous stem cell transplantation for enteropathy-associated T-cell lymphoma.	17531561
T-Cell Lymphoma	Stem Cell Exhaustion	Here we report on the feasibility, safety and efficacy of high-dose chemotherapy followed by autologous stem cell transplantation in patients with enteropathy-associated T-cell lymphoma (three upfront and one at relapse), with or without prior partial small bowel resection.	17531561
T-Cell Lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation seems unsatisfactory for patients with enteropathy-associated T-cell lymphoma.	17531561
Communicable Diseases	Stem Cell Exhaustion	Cytomegalovirus reactivation and infection post-allogeneic hematopoietic stem cell transplant continue to cause morbidity and mortality.	17531781
Cytomegalovirus Infections, Diarrhea	Stem Cell Exhaustion	Local cytomegalovirus infection in patients with diarrhea following allogeneic stem cell transplantation.	17533985
Diarrhea, Communicable Diseases	Stem Cell Exhaustion	To evaluate local cytomegalovirus (CMV) infection in patients who developed diarrhea after allogeneic hematopoietic stem cell transplantation (HSCT), histologic and molecular analysis was carried out with intestinal biopsy samples.	17533985
Diarrhea, Intestinal Diseases	Stem Cell Exhaustion	Endoscopic examinations with histologic and molecular analysis may be important in the early treatment and the prevention of intestinal CMV disease in patients with diarrhea after allogeneic stem cell transplantation.	17533985
Degenerative polyarthritis	Stem Cell Exhaustion	These results show that cells with stem cell characteristics were isolated from the IPFP of elderly patients with osteoarthritis and that their response to chondrogenic culture was enhanced by lowered oxygen tension, which upregulated HIF2alpha and increased the synthesis and assembly of matrix during chondrogenesis.	17537234
Degenerative polyarthritis	Stem Cell Exhaustion	Hypoxic conditions increase hypoxia-inducible transcription factor 2alpha and enhance chondrogenesis in stem cells from the infrapatellar fat pad of osteoarthritis patients.	17537234
Structure of articular cartilage	Stem Cell Exhaustion	Stem cells derived from the infrapatellar fat pad (IPFP) are a potential source of stem cells for the repair of articular cartilage defects.	17537234
Hypoxia	Stem Cell Exhaustion	Hypoxia has been shown to improve chondrogenesis in adult stem cells.	17537234
Degenerative polyarthritis, Hypoxia	Stem Cell Exhaustion	In this study we investigated the effects of hypoxia on gene expression changes and chondrogenesis in stem cells from the IPFP removed from elderly patients with osteoarthritis at total knee replacement.	17537234
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Neural stem cell markers, nestin and musashi proteins, in the progression of human glioma: correlation of nestin with prognosis of patient survival.	17537489
Glioblastoma Multiforme Pathway, Glioma	Stem Cell Exhaustion	The presented data links the invasive glioma cells to CNS precursor cells, indicating that the most malignant cells in the gliomas may well be closely related to the glioma stem cells.	17537489
Hematological Disease	Stem Cell Exhaustion	In 9 patients (3 with hematologic disease), routine RhD typing showed a mixture of D-positive and D-negative red cells not attributable to transfusion or hematopoietic stem-cell transplantation.	17537994
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft versus host disease (GVHD) occurs after a hematopoietic stem cell transplantation (HSCT) when the donor's immune system rejects the recipient's body, leading to significant morbidity and mortality.	17539221
Lymphoma, Follicular	Stem Cell Exhaustion	Histopathological bone marrow changes after reduced-intensity hematopoietic stem cell transplantation for follicular lymphoma involving bone marrow.	17539969
Toxic effect, Lymphoma	Stem Cell Exhaustion	Allogeneic stem cell transplantation (allo-SCT) is used as curative therapy for malignant lymphoma, and reduced-intensity hematopoietic stem cell transplantation (RIST) is sometimes performed to avoid the toxicity and mortality associated with myeloablative allo-SCT.	17539969
Neoplasms, Teratoma	Stem Cell Exhaustion	Teratoma is a rare developmental neoplasm that arises from totipotential tumor stem cells.	17540035
Neutropenia, Pulmonary Aspergillosis, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	A 35-year-old man developed invasive pulmonary aspergillosis (IPA) with severe neutropenia after umbilical cord stem cell transplantation for chronic myelogenous leukemia.	17541234
Carcinogenic Chlorinated Hydrocarbon	Stem Cell Exhaustion	Some investigators suggested that CHC originated from intermediate type cells or progenitor cells with dual potential.	17542282
Neoplasms	Stem Cell Exhaustion	Our study provides evidence for widespread neuronal differentiation in ODGs, suggesting that these tumours may be derived from progenitor cells with limited commitment.	17543079
Basal cell hyperplasia	Stem Cell Exhaustion	In addition, immunostaining reveals preferential activation of the IGF-IR in p63-positive cells in areas of intermediate basal cell hyperplasia in the peripheral zone, indicating that prostate progenitor cells are highly sensitive to increases in local IGF-I levels.	17545516
Pure Red-Cell Aplasia	Stem Cell Exhaustion	We report a case of 64-year-old patient with pure red cell aplasia (PRCA) who was intolerant of conventional immunosuppressive therapies but achieved a complete long-term remission following autologous hematologic stem cell transplant (HSCT).	17546635
Pancreatic carcinoma	Stem Cell Exhaustion	Increased levels of IgG antibodies against peptides of the prostate stem cell antigen in the plasma of pancreatic cancer patients.	17549363
Pancreatic carcinoma	Stem Cell Exhaustion	This study examined whether or not the plasma levels of IgG antibodies (IgGs) reactive to peptides derived from the prostate stem cell antigen (PSCA), which is highly expressed in pancreatic cancer cells, were elevated in patients with pancreatic cancer.	17549363
Infection caused by Helicobacter pylori	Stem Cell Exhaustion	Helicobacter pylori infection induces candidate stem cell marker Musashi-1 in the human gastric epithelium.	17549630
Neoplasms, Pancreatic carcinoma	Stem Cell Exhaustion	Therefore, PDX-1-positive cells may be tumor stem cells and PDX-1 may act as alternate surface marker of pancreatic cancer stem cells.	17552012
Gastrointestinal Neoplasms, Neoplasms	Stem Cell Exhaustion	Gastrointestinal mesenchymal tumors are a group of tumors, which originate from the mesenchymal stem cells of the gastrointestinal tract.	17553326
Adult onset, Disease, Myeloproliferative disease, Myeloid Leukemia, Chronic, Leukemia, B-Cell, MVD gene	Stem Cell Exhaustion	Using a murine model of chronic myeloid leukemia, an adult-onset malignancy that arises from transformation of hematopoietic stem cells by the BCR-ABL(P210) oncogene, we demonstrate that young bone marrow (BM) cells that were transformed with BCR-ABL(P210) initiated both a myeloproliferative disorder (MPD) and B-lymphoid leukemia, whereas BCR-ABL(P210)-transformed old BM cells recapitulated the human disease by inducing an MPD with rare lymphoid involvement.	17554060
Hematopoietic stem cells	Stem Cell Exhaustion	Diminished DNA double-strand break repair in the Lig4(Y288C) strain causes a progressive loss of haematopoietic stem cells and bone marrow cellularity during ageing, and severely impairs stem cell function in tissue culture and transplantation.	17554302
B-Cell Lymphomas	Stem Cell Exhaustion	A prospective multicenter program was performed to evaluate the combination of rituximab and high-dose (hd) sequential chemotherapy delivered with multiple autologous peripheral blood progenitor cell (PBPC) support (R-HDS-maps regimen) in previously untreated patients with diffuse large B-cell lymphoma (DLB-CL) and age-adjusted International Prognostic Score (aaIPI) score 2-3.	17554382
Thrombophilia	Stem Cell Exhaustion	Utility of the clinical practice of administering thrombophilic screening and antithrombotic prophylaxis with low-molecular-weight heparin to healthy donors treated with G-CSF for mobilization of peripheral blood stem cells.	17557562
Thrombophilia	Stem Cell Exhaustion	The aim of the study was to verify the utility of the clinical practice of administering thrombophilic screening and antithrombotic prophylaxis with low-molecular-weight heparin to healthy donors receiving granulocyte colony-stimulating factor to mobilize peripheral blood stem cells.	17557562
Pulmonary Complication	Stem Cell Exhaustion	Recently, we found an association between the variant Leu1007fsinsC of the NOD2/CARD15 gene (SNP13) and a significantly increased rate of transplant related mortality (TRM) due to intestinal and pulmonary complications in stem cell transplantation (SCT).	17558494
Multiple Myeloma	Stem Cell Exhaustion	After a median of 4 months, 25 eligible patients received intensive therapy with high-dose melphalan supported by autologous blood stem cells, so that the myeloma was in complete remission in 14 patients (37% of all patients).	17558699
Cardiotoxicity, Multiple Myeloma	Stem Cell Exhaustion	Cardiac toxicity of high-dose cyclophosphamide in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation.	17562616
Multiple Myeloma	Stem Cell Exhaustion	High-dose cyclophosphamide is a well-known mobilization regimen in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation.	17562616
PAFAH1B1 wt Allele, White blood cell count decreased	Stem Cell Exhaustion	These results indicated that the WT1-specific cytotoxic T-lymphocytes (CTLs) elicited by WT1 vaccination eradicated the WT1-expressing transformed stem or progenitor cells and that MDS patients with little normal hematopoiesis required a new strategy of WT1 vaccination to avoid severe leukocytopenia.	17562620
Chronic active Epstein-Barr virus infection	Stem Cell Exhaustion	Successful reduced-intensity stem cell transplantation with cord blood for a poor-prognosis adult with refractory chronic active epstein-barr virus infection.	17562623
Chronic Active EBV Infection of T-and NK-Cell Type, Systemic Form, Communicable Diseases	Stem Cell Exhaustion	A 56-year-old woman with a poor-prognosis chronic active Epstein-Barr virus (CAEBV) infection underwent reduced-intensity stem cell transplantation (RIST) using cryopreserved cord blood (CB).	17562623
Myeloid neoplasm, PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation following reduced-intensity stem cell transplantation (RIST) has enabled the treatment of older or medically infirm patients with myeloid malignancies; however, determining the value of RIST outcomes for myelodysplastic syndrome (MDS) is difficult because of the heterogeneity of the diseases included in most trials.	17562624
Angina Pectoris	Stem Cell Exhaustion	Intramyocardial transplantation of autologous CD34+ stem cells for intractable angina: a phase I/IIa double-blind, randomized controlled trial.	17562958
Disease of capillaries	Stem Cell Exhaustion	Transplant-associated microangiopathy (TAM) is a severe complication following allogeneic hematopoietic stem cell transplantation (HSCT) even after reduced-intensity conditioning (RIC).	17569587
Herpes Simplex Infections	Stem Cell Exhaustion	Use of long-term suppressive acyclovir after hematopoietic stem-cell transplantation: impact on herpes simplex virus (HSV) disease and drug-resistant HSV disease.	17570114
Herpes Simplex Infections	Stem Cell Exhaustion	The effect that long-term use of suppressive acyclovir (ACV) has on both overall herpes simplex virus (HSV) disease and ACV-resistant HSV disease was examined in 3 consecutive cohorts of hematopoietic stem-cell transplant (HCT) recipients (n=2049); cohort 1 received ACV for 30 days after HCT, cohort 2 received it for 1 year after HCT, and cohort 3 received it for an extended period (i.e., >1 year) if the patient's immunosuppression continued after 1 year.	17570114
Hematologic Neoplasms	Stem Cell Exhaustion	This prospective trial assessed the safety and efficacy of allogeneic hematopoietic stem cell transplantation from a HLA-matched donor with a reduced-intensity regimen (RIST) consisting of iv fludarabine 30 mg/m(2) for 6 days and oral busulfan 4 mg/kg/day for 2 days in patients older than 50 years with hematological malignancies.	17570513
PAFAH1B1 wt Allele, Dysplasia, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Myelodysplastic Syndromes (MDS) are clonal disorders of the hematopoietic stem cell frequently presenting dysplasia in erythroid and/or megakaryocytic lineage.	17570514
Chronic heart failure, Congestive heart failure	Stem Cell Exhaustion	This study investigated whether reduced levels of circulating endothelial progenitors cells (EPCs) in chronic heart failure (CHF) are secondary to an exhaustion of hematopoietic stem cells (HSCs) in the bone marrow or to reduced mobilization.	17572250
Cardiomyopathies	Stem Cell Exhaustion	Ischemic cardiomyopathy is associated with selective impairment of progenitor cell function in the bone marrow and in the peripheral blood, which may contribute to an unfavorable left ventricular (LV) remodeling process.	17572250
Myocardial Infarction	Stem Cell Exhaustion	Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure.	17572250
Acute leukemia	Stem Cell Exhaustion	HLA-identical haematopoietic stem cell transplantation for acute leukaemia in children: less relapse with higher biologically effective dose of TBI.	17572715
Therapy-related myelodysplastic syndrome	Stem Cell Exhaustion	Because the same translocation reappeared and sustained for more than 8 months after second stem cell transplantation, we revised the diagnosis as therapy-related MDS after allogeneic transplantation.	17574966
Bone necrosis, Osteonecrosis of Jaw, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	To elucidate the mechanism leading to ONJ and to test the hypothesis that in patients with ONJ the bisphosphonates may interfere with endothelial cell proliferation, using flow cytometric analysis we evaluated the number of circulating endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) in eight patients with bisphosphonate treatment and osteonecrosis, eight multiple myeloma (MM) patients with bisphosphonates treatment without ONJ and five normal subjects.	17577204
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	DNA methylation profiling of myelodysplastic syndrome hematopoietic progenitor cells during in vitro lineage-specific differentiation.	17577921
eosinophil	Stem Cell Exhaustion	Blood eosinophilia as a marker of favorable outcome after allogeneic stem cell transplantation.	17578455
Hepatic Veno-Occlusive Disease, Spondylo-ocular syndrome	Stem Cell Exhaustion	Sinusoidal obstruction syndrome (SOS) is a frequent, troubling, and potentially fatal complication of hematopoietic stem cell transplantation.	17580188
Hematologic Neoplasms	Stem Cell Exhaustion	We retrospectively evaluated the charts of 80 consecutive patients, with 89 hematopoietic stem cell transplants for hematologic malignancies.	17580188
Graft-vs-Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	A 43-year-old woman with chronic hepatic graft-versus-host disease (GVHD) who failed previous immunosuppressive therapy with cyclosporine and prednisone was treated with tacrolimus starting on day 165 after allogeneic hematopoietic stem cell transplantation.	17580228
Graft-vs-Host Disease, Acute hepatitis	Stem Cell Exhaustion	Using human adipose tissue-derived mesenchymal stem cells as salvage therapy for hepatic graft-versus-host disease resembling acute hepatitis.	17580228
Graft-vs-Host Disease, Toxic nephropathy	Stem Cell Exhaustion	However, after changing treatment to human adipose tissue-derived mesenchymal stem cells (AMSC), we observed rapid and complete resolution of hepatic GVHD and renal toxicity.	17580228
Mycoses	Stem Cell Exhaustion	Invasive fungal infection (IFI) is a significant complication after allogeneic hematopoietic stem cell transplantation (HSCT); however, we have little information on its clinical features after reduced intensity cord blood transplantation (RICBT) for adults.	17580255
Hematological Disease	Stem Cell Exhaustion	In this report, we analyzed the outcome of 67 patients (median age, 45 years) with hematologic diseases receiving NM conditioning with fludarabine 90 mg/m(2) and total body irradiation (TBI) 200-cGy, followed by filgrastim-mobilized peripheral blood stem cell transplant from HLA identical (n = 61), 5/6 antigen-matched related (n = 1), 6/6 antigen-matched unrelated (n = 3), and 5/6 antigen-matched unrelated (n = 2) donors.	17580257
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation is a curative procedure for many patients with lymphomas, and has been shown to improve survival in patients with multiple myeloma.	17580262
Aplastic Anemia	Stem Cell Exhaustion	Even patients who have clinically recovered from aplastic anemia have diminished hematopoietic progenitor cells, so the practicability of PBPC mobilization in these individuals is unknown.	17581160
Multiple Myeloma	Stem Cell Exhaustion	Impact of lenalidomide therapy on stem cell mobilization and engraftment post-peripheral blood stem cell transplantation in patients with newly diagnosed myeloma.	17581613
Toxic effect	Stem Cell Exhaustion	Because of the false-positive results and the toxicity of salvage chemotherapy, including high-dose chemotherapy with autologous stem cell support, biopsy of the FDG-avid lesion is still needed.	17581905
Antilymphocyte Serum	Stem Cell Exhaustion	Our results seem to demonstrate that MSCs represent a good chance for stem cell cell-based therapy in ALS and that intraspinal injection of MSCs is safe also in the long term.	17582439
Aspergillosis	Stem Cell Exhaustion	Presumptive treatment strategy for aspergillosis in allogeneic haematopoietic stem cell transplant recipients.	17584800
Aspergillosis	Stem Cell Exhaustion	The onset of invasive aspergillosis (IA) after allogeneic haematopoietic stem cell transplantation (HSCT) is bimodal.	17584800
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Patients with unfavorable cytogenetic and those with secondary AML had poorer OS; about 40% of patients could mobilize a sufficient amount of PBSC for autologous stem cell transplantation.	17588476
Toxic effect	Stem Cell Exhaustion	The main end points were overall response rate (ORR) and toxicity; secondary end points were feasibility of peripheral blood stem cells (PBSC) collection, leukemia-free survival, and overall survival (OS).	17588476
Refractory Cytopenia of Childhood	Stem Cell Exhaustion	Nonmyeloablative allogeneic stem cell transplant has activity in patients with metastatic RCC.	17589297
Refractory Cytopenia of Childhood	Stem Cell Exhaustion	This phase II trial assessed the efficacy, safety, and responses in 16 patients, 10 related and 6 URD transplants after a reduced intensity conditioning regimen and stem cell transplant as a treatment for metastatic RCC.	17589297
Refractory Cytopenia of Childhood	Stem Cell Exhaustion	These results suggest that similar outcomes are possible where either related or URD were used as the stem cell source in reduced intensity stem cell transplant for metastatic RCC.	17589297
T-Cell Lymphoma	Stem Cell Exhaustion	The role of high-dose therapy and stem cell rescue in the management of T-cell malignant lymphomas: a BSBMT and ABMTRR study.	17589529
T-Cell Lymphoma	Stem Cell Exhaustion	These results demonstrate that high-dose chemotherapy with autologous stem cell rescue has a substantial role in the management of T-cell lymphoma.	17589529
Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome	Stem Cell Exhaustion	Efficacy of prophylactic transfusions using single donor apheresis platelets versus pooled platelet concentrates in AML/MDS patients receiving allogeneic hematopoietic stem cell transplantation.	17589530
Amyloidosis	Stem Cell Exhaustion	Tandem cycles of high-dose melphalan and autologous stem cell transplantation increases the response rate in AL amyloidosis.	17589534
Amyloidosis	Stem Cell Exhaustion	Clinical outcomes of patients with AL amyloidosis treated with high-dose melphalan and stem cell transplantation (HDM/SCT) are tightly linked to the achievement of a hematologic complete response (HCR).	17589534
Hepatitis B	Stem Cell Exhaustion	Ultrastructural examination of biopsy specimens obtained from children with chronic hepatitis B showed the presence of two types of oval cells, the hepatic progenitor cells and intermediate hepatic-like cells.	17589940
Fibrosis Assessment	Stem Cell Exhaustion	We found a distinct relationship between the prevalence of oval cells (hepatic progenitor cells and intermediate hepatocyte-like cells) and fibrosis stage in pediatric patients with chronic hepatitis B.	17589940
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Oxidant stress impairs in vivo reendothelialization capacity of endothelial progenitor cells from patients with type 2 diabetes mellitus: restoration by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone.	17592079
Arterial Injury	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) are thought to contribute to endothelial recovery after arterial injury.	17592079
Keratitis, Engraftment syndrome	Stem Cell Exhaustion	Bilateral marginal keratitis associated with engraftment syndrome after hematopoietic stem cell transplantation.	17592333
Keratitis, Engraftment syndrome	Stem Cell Exhaustion	To report the first case of bilateral marginal keratitis in the setting of engraftment syndrome in a patient who had undergone hematopoietic stem cell transplantation.	17592333
How Often Shortness of Breath, Exanthema, Engraftment syndrome	Stem Cell Exhaustion	Two weeks before presentation, the patient had received a matched unrelated donor peripheral blood stem cell transplant and subsequently developed engraftment syndrome with a rapid white blood cell count recovery, noninfectious fever, skin rash, and shortness of breath.	17592333
Engraftment syndrome	Stem Cell Exhaustion	Engraftment syndrome is notable for a rapid recovery of the white blood cell count after hematopoietic stem cell transplantation.	17592333
Keratitis, Conjunctivitis, Engraftment syndrome	Stem Cell Exhaustion	Patients who present with presumed conjunctivitis in the setting of autologous and allogeneic stem cell transplantation should be evaluated for engraftment syndrome-related marginal keratitis.	17592333
Hematologic Toxicity Attenuation, Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Disease control may also correlate with hematologic toxicity (p = 0.08), suggesting that glioma and marrow stem cells may share a common sensitivity to this chemotherapy regimen.	17594055
BONE MARROW PLASMACYTOSIS	Stem Cell Exhaustion	Several parameters such as serum beta2-microglobulin, serum C-reactive protein, immunoglobulin A isotype, hemoglobin, stage of disease, bone marrow plasmacytosis, age, serum creatinine, gender, stem cell transplantation at the time of diagnosis, and time to first disease progression were analyzed in association with overall survival (OS).	17594696
Stem Cell Factor	Stem Cell Exhaustion	KIT functions as the receptor for stem cell factor (SCF) and this interaction is essential for regulation of proliferation and survival, particularly for germ cells since it regulates oogenesis, folliculogenesis and spermatogenesis.	17595797
Prostate carcinoma	Stem Cell Exhaustion	Basal cell subpopulation as putative human prostate carcinoma stem cells.	17597019
Prostate carcinoma, Proliferative Inflammatory Atrophy	Stem Cell Exhaustion	The present study examines the expression of p63, glutathione S-transferase-pi (GSTP1) and alpha-methylacyl-CoAracemase (AMACR) in serial slices in proliferative inflammatory atrophy (PIA) in order to implicate that some of the basal cells are probably the putative human prostate carcinoma stem cells (PHPCSC).	17597019
Prostate carcinoma	Stem Cell Exhaustion	Therefore, we propose that the putative human prostate carcinoma stem cells probably reside within the population of type I basal cells.	17597019
melanoma	Stem Cell Exhaustion	Consistent expression of the stem cell renewal factor BMI-1 in primary and metastatic melanoma.	17597110
melanoma	Stem Cell Exhaustion	Stem cell-like cells have recently been identified in melanoma cell lines, but their relevance for melanoma pathogenesis is controversial.	17597110
melanoma, Cutaneous Melanoma, Metastatic melanoma	Stem Cell Exhaustion	To characterize the stem cell signature of melanoma, expression of stem cell markers BMI-1 and nestin was studied in 64 cutaneous melanomas, 165 melanoma metastases as well as 53 melanoma cell lines.	17597110
Aggressive behavior	Stem Cell Exhaustion	This suggests that BMI-1 mediated repression of p16(ink4a) may contribute to an increased aggressive behavior of stem cell-like melanoma cells.	17597110
Histologic type, Lymphoma	Stem Cell Exhaustion	Allogeneic stem cell transplantation following reduced-intensity conditioning can induce durable clinical and molecular remissions in relapsed lymphomas: pre-transplant disease status and histotype heavily influence outcome.	17597807
Lymphoma	Stem Cell Exhaustion	The safety and efficacy of reduced-intensity conditioning (RIC) followed by allogeneic stem cell transplantation (SCT) for relapsed lymphomas remains unresolved.	17597807
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Frontline autologous stem cell transplantation in high-risk peripheral T-cell lymphoma: a prospective study from The Gel-Tamo Study Group.	17598836
Peripheral T-Cell Lymphoma, Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Retrospective data shows that peripheral T-cell lymphoma (PTCL) patients sensitive to conventional chemotherapy for aggressive lymphomas may respond better if this treatment is consolidated with frontline autologous stem cell transplantation (ASCT).	17598836
Neoplasms	Stem Cell Exhaustion	Antitumor effect of large doses IL-2-activated HLA haploidentical peripheral blood stem cells on refractory metastatic solid tumor treatment.	17600469
Neoplasms	Stem Cell Exhaustion	The aim of this study was to evaluate the clinical efficacy of infusion of high-dose interleukin (IL)-2-activated allogeneic haploidentical peripheral blood stem cells (haplo-PBSCTs) on patients with an advanced stage of refractory solid tumors.	17600469
Brain Injuries	Stem Cell Exhaustion	Changes in circulating human endothelial progenitor cells after brain injury.	17600511
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Isolated extramedullary (EM) relapses of acute myelogenous leukemia (AML) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) have been reported to be rare, and are usually followed by bone marrow relapses.	17603242
Varicella Zoster Virus Infection, Lymphoproliferative Disorders	Stem Cell Exhaustion	Factors influencing varicella zoster virus infection after allogeneic peripheral blood stem cell transplantation: low-dose acyclovir prophylaxis and pre-transplant diagnosis of lymphoproliferative disorders.	17605742
PAFAH1B1 wt Allele	Stem Cell Exhaustion	The results of HUMARA, available in 73% of the female patients, supported the clinicopathological data in 84% as well as proved pluripotent stem cell origin in 31-75% and 21% of CMPDs and MDS, respectively.	17607372
Mantle cell lymphoma	Stem Cell Exhaustion	A 42-year-old male with stage IV mantle cell lymphoma received chemotherapy and autologous peripheral blood stem cell transplantation.	17607784
Lymphoma, Non-Hodgkin, Hypothyroidism	Stem Cell Exhaustion	Medical history included hypothyroidism for 10 years and non-Hodgkin's lymphoma in remission for 4 years after a stem cell transplant.	17608247
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Delayed attainment of full donor chimaerism following alemtuzumab-based reduced-intensity conditioning haematopoeitic stem cell transplantation for acute myeloid leukaemia and myelodysplastic syndromes is associated with improved outcomes.	17608767
Goiter	Stem Cell Exhaustion	Stem cells derived from goiters in adults form spheres in response to intense growth stimulation and require thyrotropin for differentiation into thyrocytes.	17609303
Goiter	Stem Cell Exhaustion	This study aimed to analyze under which conditions quiescent stem cells derived from human goiters can be propagated to outgrow and whether these cells have retained the capacity to differentiate into thyroid cells.	17609303
Goiter	Stem Cell Exhaustion	Quiescent stem cells derived from goiters can be propagated to form spheres that consist of highly proliferating stem cells that are able to differentiate TSH dependently into thyroid cells.	17609303
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The novel AML stem cell associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells.	17609428
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We now show that CLL-1 expression is also present on the CD34(+)CD38(-) stem- cell compartment in AML (77/89 patients).	17609428
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This AML stem-cell specificity of the anti-CLL-1 antibody under all conditions of disease and the leukemia-initiating properties of CD34(+)CLL-1(+) cells indicate that anti-CLL-1 antibody enables both AML-specific stem-cell detection and possibly antigen-targeting in future.	17609428
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In CD34(+) acute myeloid leukemia (AML), the malignant stem cells reside in the CD38(-) compartment.	17609428
Neoplasms, Neuroepithelial	Stem Cell Exhaustion	Nestin, a marker for multipotential neuroepithelial stem cells, is detected in neuroepithelial tumors and in proliferating endothelial cells (ECs) and is involved in the early stages of lineage commitment, proliferation and differentiation.	17611402
Astrocytoma	Stem Cell Exhaustion	Expression of stem cell markers in human astrocytomas of different WHO grades.	17611714
Glioma, Astrocytoma	Stem Cell Exhaustion	Because these studies have been performed with single experimental samples mostly from gliomas, we investigated the expression of the stem cell markers CD133/Prominin, Nestin, Sox-2, Musashi-1, CXCR4, Flt-4/VEGFR-3 and CD105/Endoglin in 72 astrocytomas of different WHO-grades and compared it to normal adult human brain.	17611714
Astrocytoma	Stem Cell Exhaustion	Our results show that most astrocytomas contain considerable portions of cells expressing stem cell markers.	17611714
Neoplasms	Stem Cell Exhaustion	It appears that some of these cells originate from tumour genesis (supporting the stem cell hypothesis) while others are attracted by the tumours.	17611714
Neoplasms	Stem Cell Exhaustion	Biological markers, particularly antigenic markers, have played a significant role for the characterization of these tumour stem cells (TSCc).	17611714
Atherosclerosis	Stem Cell Exhaustion	Circulating stromal osteonectin-positive progenitor cells and stenotic coronary atherosclerosis.	17612637
Coronary Arteriosclerosis	Stem Cell Exhaustion	The level of circulating stromal progenitor cells carrying osteonectin (ON), a marker of osteogenic differentiation, was evaluated by flow cytometry in blood of patients with coronary artery disease (CAD).	17612637
Hematological Disease	Stem Cell Exhaustion	The aim was to prospectively measure quality of life in patients with malignant blood disorders following stem cell transplantation (SCT) using an individualized and a standardized measure.	17614094
Hematologic Neoplasms, Aspergillosis	Stem Cell Exhaustion	Increased bone marrow iron stores is an independent risk factor for invasive aspergillosis in patients with high-risk hematologic malignancies and recipients of allogeneic hematopoietic stem cell transplantation.	17614303
Cessation of life, leukemia, Aspergillosis	Stem Cell Exhaustion	Invasive aspergillosis (IA) is a leading cause of death in patients with leukemia and those who have undergone hematopoietic stem cell transplantation.	17614303
leukemia, Mycoses	Stem Cell Exhaustion	In the current study, the authors retrospectively evaluated the bone marrow iron stores (BMIS) in patients with leukemia as well as recipients of allogeneic hematopoietic stem cell transplantation with IA (n = 33) and those without fungal infections (n = 33).	17614303
leukemia	Stem Cell Exhaustion	The prospective validation of BMIS for risk stratification in patients with leukemia or those who undergo allogeneic hematopoietic stem cell transplantation is needed.	17614303
Opiate Addiction, Deficit	Stem Cell Exhaustion	Deficit of circulating stem--progenitor cells in opiate addiction: a pilot study.	17615060
Degenerative polyarthritis	Stem Cell Exhaustion	A low molecular weight synthetic inhibitor of the RAR alpha and RAR beta receptors was able to induce chondrogenic differentiation of mesenchymal stem cells derived from osteoarthritis patients, in the absence of serum and growth factors.	17615267
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	The molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes.	17616640
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Global gene expression profiling of highly purified 5q-deleted CD34+CD38(-)Thy1+ cells in 5q- myelodysplastic syndromes (MDSs) supported that they might originate from and outcompete normal CD34+CD38(-)Thy1+ hematopoietic stem cells.	17616640
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Few but distinct differences in gene expression distinguished MDS and normal stem cells.	17616640
Specialty Type - cancer	Stem Cell Exhaustion	These studies establish the importance of molecular characterization of distinct stages of cancer stem and progenitor cells to enhance the resolution of stage-specific dysregulated gene expression.	17616640
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We evaluated the efficacy of hematopoietic stem cell transplantation (HSCT) using reduced intensity (RI) vs. myeloablative (MA) conditioning for patients with acute myeloid leukemia (AML) and myelodysplastic syndrome.	17616969
Hematologic Neoplasms	Stem Cell Exhaustion	Nonmyeloablative allogeneic stem cell transplantation in elderly patients with hematological malignancies: results from the GITMO (Gruppo Italiano Trapianto Midollo Osseo) multicenter prospective clinical trial.	17616972
Hematologic Neoplasms	Stem Cell Exhaustion	This study aimed to evaluate the efficacy of a nonmyeloablative conditioning consisting of fludarabine and TBI in patients aged > or =60 years.A total of 32 patients (median age 62 years; range 60-70) with hematological malignancies were treated with fludarabine (30 mg/m(2) x 3-5 days) and 200 cCy TBI followed by allogeneic hematopoietic stem cell transplantation (HSCT) from a matched-sibling donor.	17616972
Histiocytic sarcoma	Stem Cell Exhaustion	Thalidomide for the treatment of histiocytic sarcoma after hematopoietic stem cell transplant.	17617785
Pneumonia	Stem Cell Exhaustion	Clinical features of allogeneic hematopoietic stem cell transplantation-associated organizing pneumonia.	17618318
Pneumonia	Stem Cell Exhaustion	We describe the clinical courses and outcomes of allogeneic hematopoietic stem cell transplantation-associated organizing pneumonia (HOP) observed in our institution over the past 20 years.	17618318
Malignant Neoplasms	Stem Cell Exhaustion	Patients mobilizing large numbers of CD34+ cells ('super mobilizers') have improved survival in autologous stem cell transplantation for lymphoid malignancies.	17618321
Steroid-Refractory Pneumonitis	Stem Cell Exhaustion	To investigate further the long-term effects of daclizumab, we performed a retrospective review of 57 patients who underwent an allogeneic hematopoietic stem cell transplant from January 1993 through June 2000 and were treated with daclizumab for steroid-refractory acute GVHD.	17618322
Infection of bloodstream, allogeneic hematopoietic stem cell transplant with purging	Stem Cell Exhaustion	Epidemiology and risk factors for bloodstream infections after allogeneic hematopoietic stem cell transplantion.	17619251
Infection of bloodstream	Stem Cell Exhaustion	A total of 315 patients who underwent allogeneic Hematopoietic Stem Cell Transplantation (HSCT) during a 4-year period were analysed with the aim of collecting information on bloodstream infections (BSI).	17619251
Graft-vs-Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic graft-versus-host disease (GVHD) is a common and debilitating condition afflicting a number of allogeneic stem cell recipients more than 100 days after their transplant.	17621568
Neoplasms, Glioblastoma	Stem Cell Exhaustion	Relationship of glioblastoma multiforme to neural stem cell regions predicts invasive and multifocal tumor phenotype.	17622647
Glioblastoma	Stem Cell Exhaustion	Neural stem cells with astrocyte-like characteristics exist in the human brain subventricular zone (SVZ), and these cells may give rise to glioblastoma multiforme (GBM).	17622647
Neoplasms	Stem Cell Exhaustion	Group I GBMs may be most related to SVZ stem cells; these tumors were in intimate contact with the SVZ, were most likely to be multifocal at diagnosis, and recurred at great distances to the initial lesion(s).	17622647
Glomerulonephritis	Stem Cell Exhaustion	Membranous glomerulonephritis went into remission after the patient had received hematopoietic stem cell transplantation (HSCT).	17629750
Failure, Corneal stromal opacities	Stem Cell Exhaustion	To report a case of unilateral total limbal stem cell (LSC) failure and corneal opacification secondary to thimerosal- and contact lens-induced ocular surface toxicity.	17630628
Erythema Infectiosum	Stem Cell Exhaustion	Pure red cell aplasia due to parvovirus B19 infection transmitted probably through hematopoietic stem cell transplantation.	17631000
Anemia	Stem Cell Exhaustion	This report presents the case of a 19-year-old male who developed severe anemia shortly after successful allogeneic hematopoietic stem cell transplantation.	17631000
Communicable Diseases	Stem Cell Exhaustion	Retrospective examination of the donor's blood suggests that hematopoietic stem cells could be the source of infection.	17631000
Pfaundler-Hurler Syndrome	Stem Cell Exhaustion	Pre-stem cell transplantation enzyme replacement therapy in Hurler syndrome does not lead to significant antibody formation or delayed recovery of the endogenous enzyme post-transplant: a case report.	17631030
Pfaundler-Hurler Syndrome	Stem Cell Exhaustion	Combined enzyme replacement therapy (ERT) and stem cell transplant (SCT) were done for a two year old boy with severe Hurler syndrome(HS) with the aim to decrease transplant related complications.	17631030
Congenital heart disease	Stem Cell Exhaustion	Detection of TUNEL-positive cardiomyocytes and c-kit-positive progenitor cells in children with congenital heart disease.	17631310
Cessation of life, Congenital heart disease, altretamine/cisplatin/cyclophosphamide protocol	Stem Cell Exhaustion	To investigate the apoptotic death of cardiomyocytes and mobilization of cardiac progenitor cells in children with congenital heart disease (CHD), terminal deoxynucleotidyl-transferase-mediated dUTP nick end-labeling (TUNEL) assay and immunohistochemistry with antibody against c-kit were performed.	17631310
Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	[Reactivation of familial hemophagocytic lymphohistiocytosis after non-myeloablative cord blood stem cell transplantation resulted in the early graft failure].	17633098
Familial Hemophagocytic Lymphocytosis, Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	A 4-year-old girl with familial hemophagocytic lymphohistiocytosis (FHL) underwent unrelated cord blood stem cell transplantation (uCBSCT) using the fludarabine-based non-myeloablative conditioning regimen.	17633098
Familial Hemophagocytic Lymphocytosis	Stem Cell Exhaustion	Our case suggests the necessity of the conditioning regimen to eradicate host lymphocytes in the stem cell transplantation for FHL, and the significance of HLA DNA-typing in uCBSCT for pediatric patients.	17633098
Primary Myelofibrosis, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	During the course of treatment with imatinib mesylate for chronic myelogenous leukemia which developed from agnogenic myeloid metaplasia accompanied with t(12;17)(q24;q11) translocation, the co-existence of two clones derived from, possibly, stem cells was identified.	17633103
Niemann-Pick Disease, Type B, Autosomal Recessive Disorder	Stem Cell Exhaustion	Correction of enzyme levels with allogeneic hematopoeitic progenitor cell transplantation in Niemann-Pick type B. Niemann-Pick type B (NP) is an autosomal recessive lysosomal storage disorder with variable phenotypes for which few patients have undergone hematopoietic progenitor cell (HPC) transplantation.	17635007
Impaired T cell function	Stem Cell Exhaustion	Endothelial progenitor cell dysfunction: mechanisms and therapeutic approaches.	17635570
Autoimmune Diseases, Hematological Disease, Neoplasms	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) is being used increasingly in an attempt to cure many hematological disorders, solid tumors and autoimmune diseases.	17637693
Lymphoma, Follicular	Stem Cell Exhaustion	Long-term follow-up of high-dose treatment with autologous haematopoietic progenitor cell support in 693 patients with follicular lymphoma: an EBMT registry study.	17637813
Lymphoma, Follicular	Stem Cell Exhaustion	To evaluate the outcome of a large series of patients who received high-dose treatment (HDT) for follicular lymphoma (FL), 693 patients undergoing HDT (total-body irradiation (TBI)-containing regimen: 58%; autologous bone marrow (BM)/peripheral blood progenitor cells (PBPCs): 378/285 patients) were included in the study.	17637813
Central Neurocytoma	Stem Cell Exhaustion	These findings suggest that central neurocytoma or progenitor cells have the potential for oligodendrocytic and astrocytic transformation with different genetic aberrations.	17639893
Precursor cell lymphoblastic lymphoma, Acute lymphocytic leukemia	Stem Cell Exhaustion	Phase II study of chemotherapy and stem cell transplantation for adult acute lymphoblastic leukemia or lymphoblastic lymphoma: Japan Clinical Oncology Group Study 9004.	17640299
Graft-vs-Host Disease, Toxic effect	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation is frequently complicated by syndromes characterized by a disruption of the endothelial integrity such as graft-versus-host disease or liver toxicity.	17640598
Lymphoma, Follicular	Stem Cell Exhaustion	A 15-year analysis of early and late autologous hematopoietic stem cell transplant in relapsed, aggressive, transformed, and nontransformed follicular lymphoma.	17640600
Lymphoma, Follicular	Stem Cell Exhaustion	Autologous stem cell transplant (ASCT) has been shown to be an effective treatment for follicular lymphoma (FL).	17640600
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Natural history of metastatic renal cell carcinoma in patients who underwent consultation for allogeneic hematopoietic stem cell transplantation.	17640602
Renal Cell Carcinoma Pathway, Refractory Cytopenia of Childhood	Stem Cell Exhaustion	We characterized the natural history of metastatic renal cell carcinoma (RCC) and identified prognostic factors among patients who did or did not undergo allogeneic hematopoietic stem cell transplantation (HSCT).	17640602
Endothelial dysfunction	Stem Cell Exhaustion	Numerical and functional impairment of circulating endothelial progenitor cells (EPCs) is thought to contribute to endothelial dysfunction and the associated increase in cardiovascular risk.	17640824
BCR gene	Stem Cell Exhaustion	The infused cell dose expressed as in vitro progenitor cell growth represents the most important pre-transplant factor affecting the long-term outcome after an unrelated CBT in young patients with high risk ALL.	17640857
Prostate carcinoma	Stem Cell Exhaustion	Reverse transcriptase-polymerase chain reaction and immunohistochemical studies for detection of prostate stem cell antigen expression in prostate cancer: potential value in molecular staging of prostate cancer.	17645609
Prostate carcinoma, Passive Cutaneous Anaphylaxis	Stem Cell Exhaustion	To determine whether detection of prostate stem cell antigen (PSCA) expression has potential for molecular staging in prostate cancer (PCa), we examined the relationship between established prognostic factors, biochemical recurrence (BCR) and PSCA expression.	17645609
Peripheral Blood Stem Cells, Hematologic Neoplasms	Stem Cell Exhaustion	We show closer correlation with haematopoietic reconstitution when the CD34+ cell dose is calculated using ideal (IBW) rather than actual (ABW) body weight in 218 patients receiving peripheral blood stem cell (PBSC) autograft for haematological malignancy.	17646841
Failure	Stem Cell Exhaustion	[Donor peripheral stem cells infusion for the treatment of failure of platelet recovery after allogeneic hematopoietic stem cell transplantation].	17650420
Failure	Stem Cell Exhaustion	To study the safety and effect of G-CSF mobilized donor hematopoietic stem cells infusion (GPBSCI) as the therapy for the failure of platelet recovery after allogeneic hematopoietic stem cell transplantation.	17650420
Secondary Graft Failure After Hematopoietic Cell Transplantation, Primary Graft Failure After Hematopoietic Cell Transplantation	Stem Cell Exhaustion	8 patients with primary failure of platelet recovery and 7 patients with secondary failure of platelet recovery received donor peripheral stem cells infusion.	17650420
Neoplasms, Specialty Type - cancer, Malignant Neoplasms, Adenomatous Polyps	Stem Cell Exhaustion	We show for the first time that (1) in normal colorectal crypts, epithelial stem cells in the basal crypt region express high IGF-1R levels, which decrease to low levels when these cells migrate to and differentiate in the mid and upper crypt regions; (2) in tumor initiation in aberrant crypt foci, all of the transformed cells express high levels of the IGF-1R at stem cell levels throughout the crypt axis; (3) in tumor progression in adenomatous and cancerous crypts, tumor cells of an epithelial type morphology express high levels of the IGF-1R; (4) in advanced cancers, low levels of the IGF-1R are expressed in invasive foci where cancer cells dedifferentiate to a mesenchymal-type morphology and show a loss of cell adhesion.	17651787
Colorectal Neoplasms	Stem Cell Exhaustion	In summary, this study shows that high-level IGF-1R expression in colorectal neoplasia is initiated by an abnormality of stem cell programmed differentiation in the aberrant crypt focus.	17651787
Specialty Type - cancer	Stem Cell Exhaustion	Previous studies have shown that the IGF-1R is expressed at high levels in normal embryonic stem cells and in many cancer phenotypes.	17651787
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Long-term follow-up of allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning for patients with chronic myeloid leukemia.	17652620
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Allogeneic hematopoietic stem-cell transplantation (HSCT) remains an effective strategy for inducing durable remission in chronic myeloid leukemia (CML).	17652620
Hemolysis (biological function)	Stem Cell Exhaustion	Prophylactic red blood cell exchange for prevention of severe immune hemolysis in minor ABO-mismatched allogeneic peripheral blood progenitor cell transplantation after reduced-intensity conditioning.	17655594
Allogeneic Hematopoietic Stem Cell Transplantation	Stem Cell Exhaustion	A first group of 32 patients (historical control) underwent RIC followed by allogeneic hematopoietic peripheral blood progenitor cell transplantation at our institution.	17655594
Extramedullary	Stem Cell Exhaustion	Gemtuzumab therapy for isolated extramedullary AML relapse following allogeneic stem-cell transplant.	17657254
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Isolated extramedullary relapse of acute myeloid leukemia after stem-cell transplant.	17657254
leukemia	Stem Cell Exhaustion	A matched-unrelated-donor stem-cell transplant for consolidation and donor-lymphocyte infusions were performed, followed by repeat unrelated-donor transplant for leukemia relapse in the marrow, radiation therapy and gemtuzumab ozogamicin for multiple sites of extramedullary leukemia relapse.	17657254
Neoplasms	Stem Cell Exhaustion	These alterations individually or collectively stimulate or favor a clonal proliferation and stromal invasion of tumor progenitor or stem cells.	17658698
Aspergillosis	Stem Cell Exhaustion	Risk factors and attributable mortality of late aspergillosis after T-cell depleted hematopoietic stem cell transplantation.	17662036
Aspergillosis	Stem Cell Exhaustion	Invasive aspergillosis occurs in 5-15% of allogeneic hematopoietic stem cell transplant (HSCT) recipients.	17662036
Neoplasms	Stem Cell Exhaustion	Regression of the tumor after withdrawal of cyclosporine in relapsed extranodal natural killer/T cell lymphoma following allogeneic hematopoietic stem cell transplantation.	17663389
Nose	Stem Cell Exhaustion	The prognosis of patients with advanced-stage extranodal natural killer/T cell lymphoma, nasal type (ENKL) has been generally poor, and several anecdotal reports have suggested the role of allogeneic hematopoietic stem cell transplantation (HSCT).	17663389
Hemolytic-Uremic Syndrome	Stem Cell Exhaustion	Toxic epidermal necrolysis and hemolytic uremic syndrome after allogeneic stem-cell transplantation.	17663696
Allogeneic Hematopoietic Stem Cell Transplantation, Cardiovascular Diseases	Stem Cell Exhaustion	Premature cardiovascular disease after allogeneic hematopoietic stem-cell transplantation.	17664354
Communicable Diseases	Stem Cell Exhaustion	[Preventive effects of newquinolones for endogenous infection in patients receiving allogeneic hematopoietic stem cell transplantation--comparison between bone marrow transplantation, peripheral blood stem cell transplantation, and cord blood transplantation].	17666884
Communicable Diseases	Stem Cell Exhaustion	We performed a retrospective study to examine the preventive effects of newquinolones for endogenous infection in patients receiving various allogeneic hematopoietic stem cell transplantation including bone marrow transplantation (BMT), peripheral blood stem cell transplantation (PBSCT), and cord blood transplantation (CBT).	17666884
Thalassemia	Stem Cell Exhaustion	Relatively recent studies show an increased expression of CA 15.3 on progenitor cells of the erythroid lineage and increased amounts of circulating progenitor cells even in well-transfused thalassaemic patients.	17668208
Specialty Type - cancer	Stem Cell Exhaustion	The recent increase in knowledge about cancer stem cells has attracted marked interest in ATC, since these lesions are suggested to be closely related to thyroid stem cells (TSCs).	17671725
Hematological Disease	Stem Cell Exhaustion	Haematopoietic Stem Cell Transplantation (HSCT) is one of the methods to treat neoplasmatic blood diseases.	17672198
Chronic Lymphocytic Leukemia, Plasmacytoma	Stem Cell Exhaustion	Development of solitary plasmacytoma in the internal auditory canal and inner ear after allogeneic hematopoietic stem cell transplantation for plasma cell leukemia.	17673474
Chronic Lymphocytic Leukemia, Plasmacytoma	Stem Cell Exhaustion	Here we report the first case of the development of intracranial solitary plasmacytoma in the inner ear after allogeneic stem cell transplantation (allo-SCT) in a 39-year-old Japanese female with primary plasma cell leukemia (PCL).	17673474
Amyloidosis	Stem Cell Exhaustion	Long-term outcome of patients with AL amyloidosis treated with high-dose melphalan and stem-cell transplantation.	17673601
Amyloidosis	Stem Cell Exhaustion	Long-term survival and outcome were determined for 80 patients with immunoglobulin light chain (AL) amyloidosis treated with high-dose melphalan and stem cell transplantation (HDM/SCT) more than 10 years ago.	17673601
Acute myocardial infarction	Stem Cell Exhaustion	Circulating progenitor cells (CPC) may contribute to cardiac regeneration and neovascularization after acute myocardial infarction (AMI).	17676354
Lipoma	Stem Cell Exhaustion	Isolation and identification of mesenchymal stem cells from human lipoma tissue.	17679141
Lipoma	Stem Cell Exhaustion	No literature had reported about stem cells from lipoma tissue.	17679141
Multiple Myeloma, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome after autologous peripheral blood stem cell transplantation for multiple myeloma.	17680015
Hodgkin Disease, PAFAH1B1 wt Allele, Lymphoma, Multiple Myeloma, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Long-term survivors after autologous peripheral blood stem cell transplantation (APBSCT) for lymphoma or Hodgkin's disease are known to have a high risk of developing myelodysplastic syndrome (MDS), but the risk of MDS is not clear for patients transplanted for myeloma.	17680015
Pre-Eclampsia	Stem Cell Exhaustion	Decrease and dysfunction of endothelial progenitor cells in umbilical cord blood with maternal pre-eclampsia.	17688613
Pre-Eclampsia	Stem Cell Exhaustion	Recently, the decrease and senescence of endothelial progenitor cells (EPC) has been observed in maternal circulation with pre-eclampsia.	17688613
Acute GVH disease	Stem Cell Exhaustion	Comparison between two fludarabine-based reduced-intensity conditioning regimens before allogeneic hematopoietic stem-cell transplantation: fludarabine/melphalan is associated with higher incidence of acute graft-versus-host disease and non-relapse mortality and lower incidence of relapse than fludarabine/busulfan.	17690701
Peripheral Arterial Diseases	Stem Cell Exhaustion	Transplantation of autologous mononuclear bone marrow stem cells in patients with peripheral arterial disease (the TAM-PAD study).	17694378
Peripheral arterial occlusive disease	Stem Cell Exhaustion	Combined intraarterial and intramuscular transplantation of autologous mononuclear bone marrow stem cells is a clinically feasible and minimally invasive therapeutic option for patients with severe chronic peripheral occlusive arterial disease.	17694378
Ischemia	Stem Cell Exhaustion	From December 2004 to December 2005, 42 patients with unilateral lower limb ischemia were treated with both autologous bone marrow stem cell implantation (group A, n=21) and autologous peripheral blood stem cell implantation (group B, n=21).	17694651
Ischemia	Stem Cell Exhaustion	Bone marrow stem cell graft and peripheral blood stem cell graft are all effective in treating lower limb ischemia.	17694651
Ischemia	Stem Cell Exhaustion	[Comparative study on autologous implantation between bone marrow stem cells and peripheral blood stem cells for treatment of lower limb ischemia].	17694651
Ischemia	Stem Cell Exhaustion	To compare the effectiveness of autologous implantation between bone marrow stem cells and peripheral blood stem cells for treatment of lower limb ischemia.	17694651
Multiple Myeloma	Stem Cell Exhaustion	Post-transplant outcomes of induction therapy for myeloma: thalidomide and dexamethasone versus doxorubicin, vincristine, and dexamethasone prior to high-dose melphalan with autologous stem cell support.	17696204
Multiple Myeloma	Stem Cell Exhaustion	High-dose melphalan with autologous stem cell support improves survival as part of initial therapy for myeloma.	17696204
Multiple Myeloma	Stem Cell Exhaustion	We reviewed the records of all patients with multiple myeloma who received an autologous stem cell transplant at the University of Pennsylvania Medical Center.	17696204
Renal carcinoma, Polycythemia	Stem Cell Exhaustion	Novel somatic mutations of the VHL gene in an erythropoietin-producing renal carcinoma associated with secondary polycythemia and elevated circulating endothelial progenitor cells.	17696210
Graft-vs-Host Disease	Stem Cell Exhaustion	Host T cells affect donor T cell engraftment and graft-versus-host disease after reduced-intensity hematopoietic stem cell transplantation.	17697964
SLC16A1 wt Allele	Stem Cell Exhaustion	Mixed chimerism in the T cell compartment (MCT) after reduced-intensity stem cell transplantation (RIST) may influence immune repopulation with alloreactive donor T cells.	17697964
Peripheral Blood Stem Cells, Hematologic Neoplasms	Stem Cell Exhaustion	We previously reported data from 103 patients with hematologic malignancies (median age 54 years) who received peripheral blood stem cell (PBSC) grafts from HLA-matched unrelated donors after nonmyeloablative conditioning and were given postgrafting immunosuppression consisting of mycophenolate mofetil (MMF; administered from day 0 until day +40 with taper through day +96) and cyclosporine (CSP; given from day -3 to day +100, with taper through day 180) (historical patients).	17697966
Multiple Myeloma, Chromosome Aberrations	Stem Cell Exhaustion	We analyzed the outcome of 83 patients with clonal cytogenetic abnormalities, who underwent high-dose therapy and autologous stem cell transplantation for multiple myeloma at our institution.	17697969
Communicable Diseases	Stem Cell Exhaustion	Cytomegalovirus (CMV) infection is an important complication following allogeneic hematopoietic stem cell transplant (HSCT), but the natural history in the cord blood setting has not been well studied.	17697973
Myeloproliferative disease	Stem Cell Exhaustion	A new MALDI-TOF-based assay for monitoring JAK2 V617F mutation level in patients undergoing allogeneic stem cell transplantation (allo SCT) for classic myeloproliferative disorders (MPD).	17698191
Myeloproliferative disease, Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement	Stem Cell Exhaustion	The 8p11 myeloproliferative syndrome (EMS) is an aggressive, atypical stem cell myeloproliferative disorder associated with chromosome translocations that disrupt and constitutively activate FGFR1 by fusion to diverse partner genes.	17698633
Peripheral Blood Stem Cells, Malignant neoplasm of ovary	Stem Cell Exhaustion	Phase III trial of high-dose sequential chemotherapy with peripheral blood stem cell support compared with standard dose chemotherapy for first-line treatment of advanced ovarian cancer: intergroup trial of the AGO-Ovar/AIO and EBMT.	17698804
Peripheral Blood Stem Cells	Stem Cell Exhaustion	A randomized trial comparing high-dose sequential chemotherapy with peripheral blood stem cell (PBSC) support with platinum-based combination chemotherapy was conducted to investigate whether dose-intensification improves outcome.	17698804
Proteinuria, Amyloidosis	Stem Cell Exhaustion	Severity of baseline proteinuria predicts renal response in immunoglobulin light chain-associated amyloidosis after autologous stem cell transplantation.	17699449
Organ Dysfunction Scores	Stem Cell Exhaustion	High-dose melphalan followed by autologous stem cell transplantation has been shown to improve organ dysfunction and survival.	17699449
Proteinuria	Stem Cell Exhaustion	This study showed that severe proteinuria and high cTnT negatively affected renal response after autologous stem cell transplantation.	17699449
Acute Promyelocytic Leukemia	Stem Cell Exhaustion	High incidence of secondary failure of platelet recovery after autologous and syngeneic peripheral blood stem cell transplantation in acute promyelocytic leukemia.	17700597
Disease remission	Stem Cell Exhaustion	We found that LDH >330 U/l (1.5 times the upper limit of normal at our institution), older age, active disease, peripheral stem cell graft and male-to-male transplant were significant adverse predictors of survival.	17700600
Urinary Incontinence, CTCAE 5.0	Stem Cell Exhaustion	Transurethral ultrasonography-guided injection of adult autologous stem cells versus transurethral endoscopic injection of collagen in treatment of urinary incontinence.	17701044
Hematological Disease, Thrombocythemia, Essential	Stem Cell Exhaustion	Essential thrombocythemia (ET) is an acquired clonal hematological stem-cell disorder that is characterized by a persistent increase in platelet count over 600,000/microl and elevated megakaryocyte levels in the bone marrow.	17701105
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GVHD) is the main complication of allogeneic stem cell transplantation.	17702900
Anemia	Stem Cell Exhaustion	Collection of mobilized peripheral blood stem cells from a donor with severe iron deficient anemia.	17703461
Anemia, idarubicin	Stem Cell Exhaustion	We report a 45-year-old woman with iron deficient anemia (IDA) who underwent a collection of allogeneic peripheral blood stem cells (PBSCs) induced by granulocyte-colony stimulating factor (G-CSF) after a rapid improvement of IDA by iron replacement.	17703461
Tooth structure	Stem Cell Exhaustion	Here we propose the hypothesis that adipose derived stem cells could be induced into odontogenic lineage and might be used as suitable seeding cells for tooth regeneration to replace the lost tooth of elderly patients.	17703893
Neoplasms, Medulloblastoma	Stem Cell Exhaustion	We conducted a twin case-control study to investigate neurocognitive and behavioral outcome in a preschool patient who was 16 months old at diagnosis of medulloblastoma and was treated with surgery, chemotherapy, stem cell transplant, and focal radiation to the tumor bed.	17704358
Childhood Breast Carcinoma	Stem Cell Exhaustion	Intensive cyclic chemotherapy and transplantation of autologous peripheral blood progenitor cells (PBPC) or whole blood in high-risk breast cancer - follow up at 10 years.	17704748
Toxic effect	Stem Cell Exhaustion	To overcome haematological toxicity transplantations of autologous peripheral blood progenitor cells (PBPCs) or whole blood enriched of PBPC were used.	17704748
Failure	Stem Cell Exhaustion	Failure to achieve a threshold dose of CD34+ CD110+ progenitor cells in the graft predicts delayed platelet engraftment after autologous stem cell transplantation.	17704793
Gammopathy, Chronic graft-versus-host disease	Stem Cell Exhaustion	Clonal gammopathies following alemtuzumab-based reduced intensity conditioning haematopoietic stem cell transplantation: association with chronic graft-versus-host disease and improved overall survival.	17704796
Gammopathy, CTSG wt Allele	Stem Cell Exhaustion	The presence of clonal gammopathies (CG) has been reported following both conventional myeloablative and autologous haematopoietic stem cell transplantation (HSCT).	17704796
Neoplasms, Stem Cell Factor	Stem Cell Exhaustion	The known niches in which the Type II tumours develop have in common that they contain feeder cells expressing stem cell factor (SCF) - the ligand for the SCF receptor c-KIT, involved in proliferation and survival of PGCs/gonocytes - and contain GBY including the gene TSPY.	17705807
Specialty Type - cancer	Stem Cell Exhaustion	Straw cells were also reproduced in vitro from human cancer cells (THP1, CACO2, and MCF7) and mouse stem cells (D1 and adipose D1) by dehydrating cultured cells.	17705822
Neoplasms, Central neuroblastoma	Stem Cell Exhaustion	It is beneficial to improve the prognosis of neuroblastoma through an early diagnosis and a comprehensive therapy including total resection of the primary tumor, autologous peripheral blood stem cell transplantation and intensive chemotherapy.	17706038
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	We developed a modified statistical model based on histologic grade and other variables to describe the time-dependent outcome for autologous stem cell transplant (autotransplant) performed for non-Hodgkin's lymphoma (NHL) based on histologic grade and other variables.	17707140
Multiple Myeloma	Stem Cell Exhaustion	[Double times of autologous peripheral blood stem cell transplantation to treat multiple myeloma].	17708821
Multiple Myeloma	Stem Cell Exhaustion	In order to explore the security and feasibility of double autologous peripheral blood stem cell transplantation (APBSCT) for treatment of multiple myeloma, a 49 years old female patient with multiple myeloma was therapied with double APBSCT.	17708821
Leukemia, Mast-Cell	Stem Cell Exhaustion	Kit encoding mRNA isolated from mast cell progenitors in peripheral blood from 17 patients with a mast cell activation disorder and from 5 healthy volunteers as well as from the human mast cell leukemia cell line HMC1 was analyzed for alterations.	17710669
Coronary heart disease	Stem Cell Exhaustion	[Effect of intracoronary adenovirus vector encoding hepatocyte growth factor gene on hematopoietic stem cells mobilization in patients with extensive coronary heart disease].	17711706
Coronary heart disease	Stem Cell Exhaustion	To investigate the effect of intracoronary adenovirus vector encoding hepatocyte growth factor gene (Ad(5)-HGF) on hematopoietic stem cells mobilization in patients with extensive coronary heart disease.	17711706
Sepsis	Stem Cell Exhaustion	Because of his poor response to induction chemotherapy, stem cell transplantation was suggested, but the patient died of sepsis before the therapeutic procedure could take place.	17711803
leukemia	Stem Cell Exhaustion	Hox genes are implicated in hematopoietic stem cell (HSC) regulation as well as in leukemia development through translocation with the nucleoporin gene NUP98.	17712416
leukemia	Stem Cell Exhaustion	Interestingly, an engineered NUP98-HOXA10 (NA10) fusion can induce a several hundred-fold expansion of HSCs in vitro and NA10 and the AML-associated fusion gene NUP98-HOXD13 (ND13) have a virtually indistinguishable ability to transform myeloid progenitor cells in vitro and to induce leukemia in collaboration with MEIS1 in vivo.	17712416
Meningioma, Neoplasms	Stem Cell Exhaustion	Various theories may explain the occurrence of extramedullary hematopoiesis occurring within a meningioma in our patient, such as hematopoietic differentiation of multipotent mesenchymal tumor cells; direct extension of hematopoietic activity from the neighboring marrow cavity; displacement from bone marrow of stem cells that settle and develop in tissues where capillaries and blood vessels proliferate, such as a meningioma; or congenital heterotopia of totipotent connective tissue cells, which, under certain circumstances, may transform into hematopoietic tissue.	17714768
Ischemia	Stem Cell Exhaustion	[Autologous transplantation of peripheral blood stem cell in treatment of critical limb ischemia].	17717827
Usual Severity Pain, Ulcer	Stem Cell Exhaustion	Autologous peripheral blood stem cell transplantation is able to induce functional angiogenesis in ischemic limb, which can significantly reduce rest pain, increase walk distance, and promote ulcer healing.	17717827
Ischemia	Stem Cell Exhaustion	To apply autologous transplantation of peripheral blood stem cells in the treatment of critical limb ischemia.	17717827
Usual Severity Pain, Ulcer	Stem Cell Exhaustion	One year after implanted peripheral blood stem cells, the pain scale decreased from 5 to 0, the ankle-brachial pressure index (ABI) increased from 0.30 to 0.46, the pain-free walking distance and maximal walking distance increased from 0.15 to 0.72 km and 0.96 to 2.13 km separately, from a total of 6 of 15 limb ulcers of transplanted patients 5 were healed after cell transplantation.	17717827
Hematologic Neoplasms	Stem Cell Exhaustion	Case-referent comparison of cognitive functions in patients receiving haematopoietic stem-cell transplantation for haematological malignancies: two-year follow-up results.	17719220
Neurotoxicity Syndromes	Stem Cell Exhaustion	During bone marrow or haematopoietic stem-cell transplantation (HSCT), potentially neurotoxic treatments are used.	17719220
Coronary Arteriosclerosis	Stem Cell Exhaustion	Effects of plasma adiponectin levels on the number and function of endothelial progenitor cells in patients with coronary artery disease.	17721014
Coronary Arteriosclerosis	Stem Cell Exhaustion	It is not known whether plasma adiponectin levels are associated with the number and function of endothelial progenitor cells (EPCs) in patients with coronary artery disease (CAD).	17721014
Malignant neoplasm of brain, Neoplasms	Stem Cell Exhaustion	Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells.	17722061
Neoplasms	Stem Cell Exhaustion	Emerging evidence suggests that neural stem cells and brain tumors regulate their proliferation via similar pathways.	17722061
Adult Glioblastoma	Stem Cell Exhaustion	Furthermore, we show that MELK siRNA dramatically inhibits proliferation and, to some extent, survival of stem cells isolated from glioblastoma in vitro.	17722061
Neoplasms	Stem Cell Exhaustion	These results demonstrate a critical role for MELK in the proliferation of brain tumors, including their stem cells, and suggest that MELK may be a compelling molecular target for treatment of high-grade brain tumors.	17722061
Hematologic Neoplasms	Stem Cell Exhaustion	Consecutive patients with hematologic malignancies requiring intensive chemotherapy including autologous stem cell transplantation were eligible.	17723127
Cessation of life, Acute leukemia	Stem Cell Exhaustion	Single nucleotide polymorphisms in the NOD2/CARD15 gene are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem-cell transplantation with unrelated donors.	17724347
Cessation of life, Acute leukemia	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) is an important option in the management of acute leukemia, but the risk of disease relapse and death remains appreciable.	17724347
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Reduced-intensity conditioning for allogeneic hematopoietic stem cell transplantation with fludarabine and melphalan is associated with durable disease control in myelodysplastic syndrome.	17724447
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We retrospectively evaluated the outcome of reduced-intensity conditioning (RIC) followed by allogeneic hematopoietic stem cell transplantation (HCT) in 43 patients with myelodysplastic syndrome (MDS) or AML arising from MDS.	17724447
HIV-1 Infection Pathway, HIV Infections	Stem Cell Exhaustion	To explore this difference we performed a cross-sectional exploratory study on the effect of HIV-1 infection on hematopoiesis in Botswana by examining hematological presentation, HIV disease state, hematopoietic progenitor cell number, and circulating viral levels in HIV-infected patients and HIV-uninfected controls.	17725416
HIV-1 Infection Pathway	Stem Cell Exhaustion	These results demonstrate a direct association between HIV-1 infection in southern Africa and hematopoietic progenitor cell health.	17725416
Myopathy	Stem Cell Exhaustion	Mesoangioblasts are a new class of adult stem cells of mesodermal origin, potentially useful for the treatment of primitive myopathies of different etiology.	17761758
Hemarthrosis	Stem Cell Exhaustion	Isolation and characterization of connective tissue progenitor cells derived from human fracture-induced hemarthrosis in vitro.	17763429
Hemarthrosis	Stem Cell Exhaustion	In our search for alternative sources of connective tissue progenitor cells that can be obtained with minimal invasion, we studied human intraarticular fracture-induced hemarthrosis of the knee and attempted to isolate connective tissue progenitors from the hemarthrosis.	17763429
Hemarthrosis	Stem Cell Exhaustion	These results demonstrate that human intraarticular fracture-induced knee hemarthrosis contains connective tissue progenitor cells with morphologic features, immunophenotypic markers, and differentiation potential that are similar to bone marrow stromal cells.	17763429
Childhood Breast Carcinoma	Stem Cell Exhaustion	Between March 1997 and June 2004, a total of 54 women with breast cancer who has at least 8 metastatic lymph nodes underwent high-dose chemotherapy with hematopoietic stem cell transplantation in Gulhane Military Medical School, Ankara, Turkey.	17768463
Cardiomyopathies, Mucopolysaccharidosis I	Stem Cell Exhaustion	This report highlights three important clinical issues: (1) MPS IH must be considered in infants with cardiomyopathy; (2) early ERT may have a significant impact on short-term outcome in children less than 18 months old with severe cardiomyopathy; (3) our report confirms that patients in poor condition benefit from ERT before stem cell transplantation.	17768668
Specialty Type - cancer	Stem Cell Exhaustion	AMD3100 is a drug capable of mobilizing peripheral blood stem cells (PBSCs) in donors and in cancer patients as a single agent or in combination with granulocyte-colony-stimulating factor (G-CSF).	17784839
Neoplasms, Multiple Myeloma	Stem Cell Exhaustion	Phase II PETHEMA trial of alternating bortezomib and dexamethasone as induction regimen before autologous stem-cell transplantation in younger patients with multiple myeloma: efficacy and clinical implications of tumor response kinetics.	17785704
Hematologic Neoplasms, Mycoses	Stem Cell Exhaustion	Prior invasive fungal infection (IFI) has historically limited the use of allogeneic stem cell transplantation for patients with hematologic malignancies.	17786717
Hematologic Neoplasms	Stem Cell Exhaustion	The estimated 45% 2-year survival in this series is similar to that for other patients with high risk hematologic malignancy undergoing stem cell transplantation.	17786717
Mycoses	Stem Cell Exhaustion	We conclude that suspected prior invasive fungal infection should not preclude the use of allogeneic stem cell transplantation.	17786717
Hematological Disease	Stem Cell Exhaustion	To evaluate efficacy of allogenic transplantation of hemopoietic stem cells (allo-THSC) from non-relative donor in patients with hematological diseases in the Clinic of Bone Marrow Transplantation at L.P. Pavlov St-Petersburg Medical Academy for the period 2000-2006.	17802788
Hematological Disease	Stem Cell Exhaustion	[Recovery of peripheral blood lymphocytes in patients with hematological diseases after allogenic non-relative transplantation of hemopoietic stem cells].	17802789
Hematologic Neoplasms	Stem Cell Exhaustion	[Allogenic transplantation of hemopoietic stem cells in low-intensity regimes in patients with hematological malignancies].	17802790
Complication Aspects, Hematologic Neoplasms	Stem Cell Exhaustion	To test feasibility of transplantation of hemopoietic stem cells (THSC) with conditioning in low-intensity regimen associated with minimal toxic complications and engraftment in patients with hematological malignancy (HM) from a high risk group.	17802790
Adult T-Cell Lymphoma/Leukemia	Stem Cell Exhaustion	The RUNX1/AML1 gene encodes a transcription factor essential for the generation of hematopoietic stem cells and is frequently targeted in human leukemia.	17823240
Autoimmune Diseases	Stem Cell Exhaustion	[A prospective and randomized study of two conditioning regimens in treatment of severe systemic autoimmune diseases with autologous peripheral blood stem cell transplantation].	17825150
Autoimmune Diseases	Stem Cell Exhaustion	To investigate the differences in immune reconstitution, hematopoietic reconstitution, efficacy, and complication between the two conditioning regimens with or without total body irradiation (TBI) in patients with refractory and severe autoimmune diseases (AID) who receiving autologous peripheral blood stem cell transplantation (APBSCT).	17825150
Kidney Failure, Acute, Purpura, Thrombotic Thrombocytopenic	Stem Cell Exhaustion	A case report of thrombotic thrombocytopenic purpura and severe acute renal failure post non-myeloablative allogeneic peripheral blood stem cell transplantation treated with plasma exchange and hemodialysis.	17845402
Electrocardiogram: myocardial infarction (finding), Acute myocardial infarction	Stem Cell Exhaustion	Bone marrow derived mesenchymal cell mobilization by granulocyte-colony stimulating factor after acute myocardial infarction: results from the Stem Cells in Myocardial Infarction (STEMMI) trial.	17846310
Alopecia	Stem Cell Exhaustion	Six cases of permanent alopecia after various conditioning regimens commonly used in hematopoietic stem cell transplantation.	17846605
Alopecia	Stem Cell Exhaustion	Irreversible alopecia has been reported after high-dose chemotherapy (HDC) and hematopoietic stem cell transplantation (HSCT) especially related to BuCy containing conditioning regimens; however, the overall incidence is not known.	17846605
Osteosarcoma	Stem Cell Exhaustion	Expression of serum amyloid A transcripts in human bone tissues, differentiated osteoblast-like stem cells and human osteosarcoma cell lines.	17849429
Hodgkin Disease, Primary Myelofibrosis	Stem Cell Exhaustion	Myelofibrosis with myeloid metaplasia in a patient with relapsed Hodgkin's lymphoma who underwent autologous hematopoietic stem cell transplantation.	17852452
Malignant Neoplasms	Stem Cell Exhaustion	Second malignancies after autologous haematopoietic stem-cell transplantation (AHSCT) are well-known long-term complications.	17852452
Shock, Cardiogenic	Stem Cell Exhaustion	[Successful therapy of patients in therapy-resistant cardiogenic shock with intracoronary, autologous bone marrow stem cell transplantation].	17853349
Shock, Cardiogenic	Stem Cell Exhaustion	The intracoronary stem cell transplantation may reduce the mortality of otherwise treatment-resistant cardiogenic shock.	17853349
Herpetic whitlow, Herpes Simplex Infections, Genital ulcers	Stem Cell Exhaustion	Herpes simplex virus (HSV)-2 caused a genital ulcer in a 40-year-old allogenic stem cell recipient, and a secondary herpetic whitlow appeared during 2 months of acyclovir (ACV) therapy.	17854045
Hematologic Neoplasms, Neoplasms	Stem Cell Exhaustion	It is reported that it controlled the self-renewal of leukemic and breast cancer stem cell and was overexpressed in some solid tumors and hematologic malignancies.	17854272
Amyloidosis	Stem Cell Exhaustion	High-dose chemotherapy followed by autologous hematopoietic stem-cell transplantation has been reported to provide higher response rates and better overall survival than standard chemotherapy in immunoglobulin-light-chain (AL) amyloidosis, but these two strategies have not been compared in a randomized study.	17855669
Amyloidosis	Stem Cell Exhaustion	We conducted a randomized trial comparing high-dose intravenous melphalan followed by autologous hematopoietic stem-cell rescue with standard-dose melphalan plus high-dose dexamethasone in patients with AL amyloidosis.	17855669
Amyloidosis	Stem Cell Exhaustion	The outcome of treatment of AL amyloidosis with high-dose melphalan plus autologous stem-cell rescue was not superior to the outcome with standard-dose melphalan plus dexamethasone.	17855669
Amyloidosis	Stem Cell Exhaustion	Patients (age range, 18 to 70 years) with newly diagnosed AL amyloidosis were randomly assigned to receive intravenous high-dose melphalan plus autologous stem cells or oral melphalan plus oral high-dose dexamethasone.	17855669
Multiple Myeloma	Stem Cell Exhaustion	Melphalan and dexamethasone for patients with multiple myeloma who are not candidates for autologous stem cell transplantation.	17867615
Multiple Myeloma	Stem Cell Exhaustion	We assessed the efficacy of a combination of melphalan and dexamethasone as first-line therapy in patients with multiple myeloma who were not candidates for autologous stem cell transplantation.	17867615
Multiple Myeloma	Stem Cell Exhaustion	The combination of melphalan and dexamethasone is safe and effective in patients with multiple myeloma who are not candidates for autologous stem cell transplantation.	17867615
Specialty Type - cancer, Malignant neoplasm of ovary, Neoplasms	Stem Cell Exhaustion	Cancer stem cells have been isolated from several solid tumors including prostate, colon, liver, breast, and ovarian cancer.	17868344
Degenerative polyarthritis	Stem Cell Exhaustion	Chondrogenic potential of human adult mesenchymal stem cells is independent of age or osteoarthritis etiology.	17872501
Infection	Stem Cell Exhaustion	A study of incidence and characteristics of infections in 476 patients from a single center undergoing autologous blood stem cell transplantation.	17875536
Neoplasms	Stem Cell Exhaustion	Neural transdifferentiation is increasingly recognized in neural crest and neural stem cell tumors.	17875653
Hematologic Neoplasms, Eczema, CTCAE	Stem Cell Exhaustion	Within a large population of individuals who underwent allogeneic stem cell transplantation because of hematologic malignancy, a group of patients was identified in whom severe and persistent eczema developed.	17875877
Allogeneic Hematopoietic Stem Cell Transplantation, Eczema	Stem Cell Exhaustion	We prospectively evaluated 10 adult patients with unexplained eczematous dermatosis after allogeneic hematopoietic stem cell transplantation.	17875877
Disease, Atopy	Stem Cell Exhaustion	Although atopy can be transmitted to an individual from a hematopoietic stem cell transplant, none of the donors in this series gave a history of an atopic disorder.	17875877
Specialty Type - cancer	Stem Cell Exhaustion	Benefits of prophylactic hematopoietic colony-stimulating factors (CSFs) in adults and children receiving cancer chemotherapy or undergoing stem-cell transplantation (SCT) are unclear.	17876022
Allogeneic Hematopoietic Stem Cell Transplantation, Respiratory Syncytial Virus Infections	Stem Cell Exhaustion	Palivizumab treatment of respiratory syncytial virus infection after allogeneic hematopoietic stem cell transplantation.	17879919
Respiratory Syncytial Virus Infections, Respiratory Tract Infections	Stem Cell Exhaustion	Among 40 allogeneic stem cell transplant recipients who developed symptomatic respiratory syncytial virus infection, including 22 patients with lower respiratory tract infection, 19 received palivizumab (9 of whom had upper respiratory tract disease).	17879919
Depression, CTCAE	Stem Cell Exhaustion	Pre-transplant depression as risk factor for survival of patients undergoing allogeneic haematopoietic stem cell transplantation.	17879971
Sepsis, Multiple Myeloma	Stem Cell Exhaustion	Sepsis, low platelet nadir at mobilization and previous IFN use predict stem cell mobilization failure in patients with multiple myeloma.	17882719
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We analyzed factors that may predict the success of stem cell mobilization in patients with multiple myeloma (MM).	17882719
Papillary adenoma, Neoplasms	Stem Cell Exhaustion	Papillary adenoma of type-II pneumocytes is a rare tumor, whose origin is suspected in progenitor cells of the bronchioloalveolar epithelium with the potential to differentiate towards type-II pneumocytes and clara cells.	17886196
Myocardial Infarction	Stem Cell Exhaustion	Most studies on stem cell transplantation therapy in both experimental heart infarct and in phase-I human clinical trials have focused on the use of undifferentiated stem cells.	17888423
Chronic graft-versus-host disease	Stem Cell Exhaustion	Altered homeostasis of CD4(+) memory T cells in allogeneic hematopoietic stem cell transplant recipients: chronic graft-versus-host disease enhances T cell differentiation and exhausts central memory T cell pool.	17889354
Communicable Diseases	Stem Cell Exhaustion	An increased risk of late infection is a serious complication after allogeneic hematopoietic stem cell transplantation (AHSCT), especially for recipients with defective CD4(+) T cell recovery.	17889354
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic graft-versus-host disease (cGVHD), a common complication after stem cell transplant (SCT), has an impact on morbidity and survival.	17889358
Celiac Disease, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Correction of celiac disease after allogeneic hematopoietic stem cell transplantation for acute myelogenous leukemia.	17893186
Autoimmune Diseases	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation has been shown to correct or improve a variety of autoimmune disorders.	17893186
Celiac Disease	Stem Cell Exhaustion	This has not been reported for celiac disease, but transmission to a hematopoietic stem cell transplantation recipient from a donor with celiac disease has been reported.	17893186
Celiac Disease, Acute leukemia	Stem Cell Exhaustion	We report a 12-year-old girl with celiac disease who was diagnosed with acute leukemia and received an allogeneic hematopoietic stem cell transplant.	17893186
Celiac Disease	Stem Cell Exhaustion	Her celiac disease resolved after the hematopoietic stem cell transplant.	17893186
Embryonal Carcinoma, Neoplasms, Choriocarcinoma	Stem Cell Exhaustion	The invasive components mimic embryogenesis, including the stem cell component embryonal carcinoma (EC), the somatic lineage teratoma (TE), and the extra-embryonic tissues yolk sac tumour (YST) and choriocarcinoma (CH).	17893849
Acute leukemia	Stem Cell Exhaustion	A multicenter pilot-randomized controlled trial of the feasibility of an augmented red blood cell transfusion strategy for patients treated with induction chemotherapy for acute leukemia or stem cell transplantation.	17894791
Acute leukemia	Stem Cell Exhaustion	Patients with acute leukemia receiving induction chemotherapy or those undergoing stem cell transplantation were assigned to one of two treatment groups: standard transfusion strategy (transfusion of 2 units of red blood cells [RBCs] when their Hb level was less than 80 g/L) or an augmented transfusion strategy (transfusion of 2 units of RBCs when their Hb level was less than 120 g/L).	17894791
MYELODYSPLASTIC SYNDROME, Multiple Myeloma	Stem Cell Exhaustion	Cytogenetically defined myelodysplasia after melphalan-based autotransplantation for multiple myeloma linked to poor hematopoietic stem-cell mobilization: the Arkansas experience in more than 3,000 patients treated since 1989.	17895401
Amyloidosis	Stem Cell Exhaustion	Risk-adapted autologous stem cell transplantation with adjuvant dexamethasone +/- thalidomide for systemic light-chain amyloidosis: results of a phase II trial.	17897298
Amyloidosis	Stem Cell Exhaustion	High-dose melphalan (MEL) with autologous stem cell transplant (SCT) is an effective therapy for systemic AL amyloidosis (AL), but treatment-related mortality (TRM) has historically been high.	17897298
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Patients with myelodysplasia (MDS) show a differentiation defect in the multipotent stem-cell compartment.	17898317
PAFAH1B1 wt Allele	Stem Cell Exhaustion	We now show that SDF-1-induced migration of CD34(+) progenitor cells from MDS patients is severely impaired.	17898317
Degenerative polyarthritis	Stem Cell Exhaustion	Cartilage and fat pad tissue digests were obtained from 26 subjects with knee OA and compared with normal bone marrow (BM) mesenchymal stem cells (MSCs) with respect to their in vitro colony-forming potential, growth kinetics, multipotentiality and clonogenicity.	17901063
Wiskott-Aldrich Syndrome	Stem Cell Exhaustion	Long-term outcome following hematopoietic stem-cell transplantation in Wiskott-Aldrich syndrome: collaborative study of the European Society for Immunodeficiencies and European Group for Blood and Marrow Transplantation.	17901250
Chickenpox, Aplastic Anemia	Stem Cell Exhaustion	Varicella zoster-associated severe aplastic anemia in a child and its successful treatment with peripheral blood stem cell transplantation from HLA-5/6-identical donor.	17901857
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Autologous in vitro expanded mesenchymal stem cell therapy for human old myocardial infarction.	17903051
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Stem cell transplantation after myocardial infarction has been claimed to restore cardiac function.	17903051
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Eight patients with old myocardial infarction and proper inclusion criteria were injected with mesenchymal stem cells at the time of coronary artery bypass grafting or percutaneous coronary intervention (test group) and compared with eight matched patients who received the same treatment without mesenchymal stem cell injection (control group).	17903051
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Transplantation of ex vivo expanded bone marrow derived mesenchymal stem cell in patients with old myocardial infarction is a safe and feasible procedure.	17903051
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	In this study, we investigated the efficacy of autologous bone marrow derived mesenchymal stem cells in improving heart function in patients with old myocardial infarction.	17903051
Burn, CTCAE	Stem Cell Exhaustion	New approach to radiation burn treatment by dosimetry-guided surgery combined with autologous mesenchymal stem cell therapy.	17907931
Necrosis	Stem Cell Exhaustion	A secondary extension of the radiation necrosis led to a new excision of fibronecrotic tissues associated with a local cellular therapy using autologous expanded mesenchymal stem cells as a source of trophic factors to promote tissue regeneration.	17907931
Autoimmune Diseases	Stem Cell Exhaustion	Acquisition and cure of autoimmune disease following allogeneic hematopoietic stem cell transplantation.	17908668
Autoimmune Diseases	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) can either cause or eliminate autoimmune disease.	17908668
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Donor lymphocyte infusion in the treatment of first hematological relapse after allogeneic stem-cell transplantation in adults with acute myeloid leukemia: a retrospective risk factors analysis and comparison with other strategies by the EBMT Acute Leukemia Working Party.	17909197
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	To evaluate the role of donor lymphocyte infusion (DLI) in the treatment of relapsed acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (HSCT).	17909197
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Fifteen multiple myeloma (MM) patients who had failed maintenance therapy after tandem autologous stem cell transplantation underwent anti-idiotype (Id) vaccination with dendritic cells (DCs).	17910631
Stem Cell Factor	Stem Cell Exhaustion	Serum levels of G-CSF, EPO, and SCF known to mobilize BMCs were even decreased or remained unchanged, suggesting a direct effect of PTH on stem cell mobilization.	17911347
Hyperparathyroidism, Primary	Stem Cell Exhaustion	Primary hyperparathyroidism is associated with increased circulating bone marrow-derived progenitor cells.	17911347
Neoplasms	Stem Cell Exhaustion	The release of progenitor cells occurs in physiological and pathological conditions and was shown to contribute to neovascularization in tumors and ischemic tissues.	17911347
Hyperparathyroidism, Primary	Stem Cell Exhaustion	In the present study we sought to investigate prospectively the effect of primary hyperparathyroidism (PHPT) on mobilization of bone marrow-derived progenitor cells.	17911347
Retroperitoneal sarcoma, Malignant Neoplasms	Stem Cell Exhaustion	Retroperitoneal sarcomas are rare malignant tumors, which are developing from mesenchymal stem cells residing in muscle, fat, and connective tissues.	17914501
Kidney Failure, Chronic, Nephrotic Syndrome, Angiolymphoid hyperplasia	Stem Cell Exhaustion	Multicentric Castleman disease with secondary AA renal amyloidosis, nephrotic syndrome and chronic renal failure, remission after high-dose melphalan and autologous stem cell transplantation.	17915620
Angiolymphoid hyperplasia	Stem Cell Exhaustion	Autologous stem cell transplantation may be an attractive choice in therapy for refractory multicentric Castleman disease.	17915620
Lymphoma, Follicular	Stem Cell Exhaustion	The pretransplant Follicular Lymphoma International Prognostic Index is associated with survival of follicular lymphoma patients undergoing autologous hematopoietic stem cell transplantation.	17917964
Lymphoma, Follicular	Stem Cell Exhaustion	We retrospectively evaluated the association of the Follicular Lymphoma International Prognostic Index (FLIPI) and other characteristics with survival following high-dose therapy and autologous stem cell transplantation (ASCT) in 207 consecutive follicular lymphoma (FL) patients.	17917964
Multiple Myeloma	Stem Cell Exhaustion	Mesenchymal stem cell abnormalities in patients with multiple myeloma.	17917971
Mycoses	Stem Cell Exhaustion	Fungal infections in recipients of hematopoietic stem cell transplants: results of the SEIFEM B-2004 study--Sorveglianza Epidemiologica Infezioni Fungine Nelle Emopatie Maligne.	17918077
Mycoses	Stem Cell Exhaustion	The purpose of our study was to evaluate the incidence and outcome of invasive fungal infection (IFI) among patients who underwent autologous or allogeneic hematopoietic stem cell transplantation (HSCT) at 11 Italian transplantation centers.	17918077
Autoimmune hemolytic anemia	Stem Cell Exhaustion	Late onset of autoimmune hemolytic anemia and pure red cell aplasia after allogeneic hematopoietic stem cell transplantation using in vivo alemtuzumab.	17918251
Pure Red-Cell Aplasia, Anemia, Hemolytic	Stem Cell Exhaustion	Hemolytic anemia and pure red cell aplasia (PRCA) after allogeneic hematopoietic stem cell transplantation (HSCT) have been reported to be mainly related to ABO-incompatibility between donor and recipient.	17918251
Multiple Myeloma	Stem Cell Exhaustion	Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99-06): a randomised trial.	17920916
Multiple Myeloma, melphalan/prednisone protocol	Stem Cell Exhaustion	Between May 22, 2000, and Aug 8, 2005, 447 previously untreated patients with multiple myeloma, who were aged between 65 and 75 years, were randomly assigned to receive either melphalan and prednisone (MP; n=196), melphalan and prednisone plus thalidomide (MPT; n=125), or reduced-intensity stem cell transplantation using melphalan 100 mg/m2 (MEL100; n=126).	17920916
Rheumatoid Arthritis	Stem Cell Exhaustion	Functional, molecular and proteomic characterisation of bone marrow mesenchymal stem cells in rheumatoid arthritis.	17921184
Autoimmune Diseases	Stem Cell Exhaustion	Bone marrow (BM) mesenchymal stem cells (MSCs) are being considered as potential therapeutic agents in various inflammatory autoimmune diseases for their tissue-repair and anti-inflammatory tissue-protective properties.	17921184
Lymphoma, Follicular	Stem Cell Exhaustion	The impact of histologic grade on the outcome of high-dose therapy and autologous stem cell transplantation for follicular lymphoma.	17922043
Lymphoma, Follicular	Stem Cell Exhaustion	The impact of the follicular lymphoma (FL) histologic grade on outcomes after high-dose therapy (HDT) and autologous stem cell transplantation (ASCT) is unknown.	17922043
Toxic effect	Stem Cell Exhaustion	This schedule was planned to repeat every 3 weeks until disease progression, severe toxicity or stem cell transplantation.	17922274
Myocardial Infarction	Stem Cell Exhaustion	Evidence that intracoronary-injected CD133+ peripheral blood progenitor cells home to the myocardium in chronic postinfarction heart failure.	17923244
Heart failure	Stem Cell Exhaustion	We demonstrate that CD133(+) progenitor cells are capable of homing to the postinfarction remodeling myocardium after intracoronary injections in patients with chronic postinfarction heart failure.	17923244
Ocular Cicatricial Pemphigoid, Burn injury, Stevens-Johnson Syndrome	Stem Cell Exhaustion	Six patients with limbal stem cell deficiency (3 with alkali burns, 2 with Stevens-Johnson syndrome, and 1 with pseudo-ocular cicatricial pemphigoid) were subjected to CLET and subsequent keratoplasty.	17923540
Myocardial Ischemia	Stem Cell Exhaustion	However, even high levels of circulating stem cells did not improve symptoms of IHD.	17924284
Pregnancy Complications, Infectious	Stem Cell Exhaustion	Infectious complications occur in most of the patients receiving high-dose therapy (HDT) and autologous hematopoietic stem cell transplantation (HSCT).	17926001
Neutropenia, Hematologic Neoplasms, Pregnancy Complications, Infectious	Stem Cell Exhaustion	The objective of the study was to analyze of the type and incidence of infectious complications during neutropenia after HDT and autologous HSCT with respect to risk factors related to stem cell transplant setting in patients treated for hematological malignancies in a single center.	17926001
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	HLA-A, B and DRB1 allele distributions in 295 CML patients (aged 4-65 years) were analysed and compared with unrelated healthy hematopoietic stem cell donors from the same ethnic and geographic background.	17926184
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Our data (1) confirm that inv(3)/t(3;3) AML has a poor prognosis (2) show that age and initial WBC are risk factors for prognosis; (3) suggest that this group may benefit from allogeneic stem cell transplantation.	17926191
Tumor necrosis, Multiple Myeloma	Stem Cell Exhaustion	Elevated tumor necrosis factor-alpha suppresses TAZ expression and impairs osteogenic potential of Flk-1+ mesenchymal stem cells in patients with multiple myeloma.	17927494
Lymphoma, HIV Infections	Stem Cell Exhaustion	Recent thymic emigrants in lymphoma patients with and without human immunodeficiency virus infection candidates for autologous peripheral stem cell transplantation.	17931391
HIV, Lymphoma	Stem Cell Exhaustion	The aim of this study was to investigate the thymic regenerative potential in 55 human immunodeficiency virus (HIV)-1 infected (HIV(+)) and non-infected (HIV(-)) lymphoma patients, candidates for autologous stem cell transplantation (ASCT).	17931391
Hypoxia	Stem Cell Exhaustion	Previously published signatures for radiosensitivity, hypoxia, proliferation, "wound," stem cells, and chromosomal instability were not significantly correlated with outcome.	17931799
Coronary Arteriosclerosis	Stem Cell Exhaustion	Endothelial progenitor cells correlate with endothelial function in patients with coronary artery disease.	17932708
Hematologic Neoplasms	Stem Cell Exhaustion	To assess the outcome of a mixed population of critical ill patients with haematological malignancies with special focus on the comparison of patients who underwent stem cell transplantation with non-transplanted patients.	17933707
Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy followed by autologous stem cell transplantation changes prognosis of IgD multiple myeloma.	17934529
Corneal Neovascularization, Burn injury	Stem Cell Exhaustion	Patients with aggressive corneal neovascularisation not responding to conventional therapy were treated with bevacizumab (Avastin) eye drops (5x/day; 5 mg/ml) for 0.5 to 6 months (mean: 3.6 +/- 2; four patients with limbal stem cell deficiency [three due to chemical burns and one inherited] and one after perforating keratoplasty).	17934753
Graft-vs-Host Disease, Hemorrhagic cystitis	Stem Cell Exhaustion	Hemorrhagic cystitis following hematopoietic stem cell transplantation: incidence, risk factors and association with CMV reactivation and graft-versus-host disease.	17935666
CLTC gene, Hemorrhagic cystitis	Stem Cell Exhaustion	The definite pathogenesis of hemorrhagic cystitis (HC) after allogenic hematopoietic stem cell transplantation (allo-HSCT) has not been well elucidated.	17935666
Neutropenia, Fever	Stem Cell Exhaustion	Prophylaxis with levofloxacin may reduce febrile episodes in neutropenic hematology patients and stem cell transplant recipients.	17938978
varicella zoster, herpesvirus 3, human, Lymphoproliferative Disorders	Stem Cell Exhaustion	Varicella zoster virus (VZV) outbreak is a significant cause of morbidity in patients suffering from blood-related malignancies, occurring mostly among those affected by lymphoproliferative disorders and in those receiving haematopoietic stem-cell transplantation.	17939903
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Chemotherapy-susceptive multiple myeloma (MM) has an indication for high-dose melphalan (HDM) followed by autologous stem cell transplantation (auto-SCT).	17940379
Malignant multiple sclerosis	Stem Cell Exhaustion	Autologous stem-cell transplantation in malignant multiple sclerosis: a case with a favorable long-term outcome.	17942513
Malignant - descriptor	Stem Cell Exhaustion	It is concluded that intensive immunosuppression followed by autologous stem cell transplantation is a viable therapeutic option in patients with malignant MS unresponsive to conventional forms of treatment.	17942513
Lymphoma, Non-Hodgkin, Cytomegalovirus	Stem Cell Exhaustion	Rituximab therapy increased post-transplant cytomegalovirus complications in Non-Hodgkin's lymphoma patients receiving autologous hematopoietic stem cell transplantation.	17943285
Complication Aspects	Stem Cell Exhaustion	From 2002 to 2005, 46 patients with relapsed indolent or high-risk aggressive B cell NHL who received rituximab (17 patients) or not (29 patients) before autologous hematological stem cell transplantation (HSCT) in one institute were retrospectively analyzed for the risk factors of CMV complications after transplantation.	17943285
Squamous cell carcinoma	Stem Cell Exhaustion	Possible involvement of stem cell factor and endothelin-1 in the emergence of pigmented squamous cell carcinoma in oral mucosa.	17944756
Stem Cell Factor	Stem Cell Exhaustion	Immunohistochemical analysis for stem cell factor (SCF) and endothelin-1, both of which are known to stimulate proliferation and differentiation of melanocytes, revealed prominent expression of both factors in the neoplastic squamous cells of the pigmented SCC, while the non-pigmented oral SCC showed little sign of either factor.	17944756
Chronic graft-versus-host disease	Stem Cell Exhaustion	Thus, we tested whether BAFF correlated with chronic GVHD disease activity and time of onset after allogeneic hematopoietic stem cell transplantation (HSCT).	17947475
Acute leukemia	Stem Cell Exhaustion	Recently, the only larger study comparing the value of the 2 stem cell sources in a young patient group was confined to transplantation from HLA-identical sibling donors in older children and adolescents with acute leukemia.	17950920
Hematologic Neoplasms	Stem Cell Exhaustion	As overall survival (OS; PBPC versus BM: 47.5% +/- 8.6% versus 51.8% +/- 10.5%; P = .88) and relapse-free survival (43.3% +/- 8.3% versus 51.8% +/- 10.5%; P = .60) are without detectable difference, PBPC and BM appear both as a valid stem cell source for HLA-matched unrelated donor transplantation in children with hematologic malignancies.	17950920
Hematologic Neoplasms	Stem Cell Exhaustion	Comparable long-term survival after bone marrow versus peripheral blood progenitor cell transplantation from matched unrelated donors in children with hematologic malignancies.	17950920
Toxic effect	Stem Cell Exhaustion	The purpose of this trial was to define the maximum tolerated duration (MTD), dose-limiting toxicity (DLT), regimen-related toxicities (RRT), and pharmacokinetics of gemcitabine infused at a fixed dose rate (FDR) of 10 mg/m2/min, combined with docetaxel/melphalan/carboplatin, using autologous stem cell transplantation (ASCT).	17950919
Neoplasms	Stem Cell Exhaustion	Phase I and pharmacokinetic study of gemcitabine administered at fixed-dose rate, combined with docetaxel/melphalan/carboplatin, with autologous hematopoietic progenitor-cell support, in patients with advanced refractory tumors.	17950919
Allogeneic Hematopoietic Stem Cell Transplantation, Central nervous system complication	Stem Cell Exhaustion	Central nervous system complications after allogeneic hematopoietic stem cell transplantation: incidence, manifestations, and clinical significance.	17950923
Prostatic Intraepithelial Neoplasias, Prostate carcinoma, prostate stem cell antigen	Stem Cell Exhaustion	Flutamide reduced prostate cancer development and prostate stem cell antigen mRNA expression in high grade prostatic intraepithelial neoplasia.	17957793
Acute leukemia	Stem Cell Exhaustion	The efficacy of an approach where LP was invariably commenced on Day 11 after intermediate-dose cyclophosphamide followed by sequential administration of granulocyte-macrophage-colony-stimulating factor (CSF) and granulocyte-CSF (Cy/GM/G) was retrospectively analyzed in 225 consecutive, unselected patients undergoing autologous hematopoietic stem cell transplantation for all diagnoses other than acute leukemia at our center.	17958545
Cervical Intraepithelial Neoplasia, Kidney Failure, Adult chronic idiopathic neutropenia	Stem Cell Exhaustion	Chronic idiopathic neutropenia (CIN) is a bone marrow (BM) failure syndrome characterized by accelerated apoptosis of myeloid progenitor cells because of a local imbalance between pro-inflammatory and anti-inflammatory cytokines.	17961177
Cervical Intraepithelial Neoplasia	Stem Cell Exhaustion	Excessive production of TGF-beta1 within the BM microenvironment of CIN patients results in downregulation of IL-10 and reduction of myeloid progenitor cells.	17961177
Myeloid	Stem Cell Exhaustion	Overexpression of sFL probably represents a compensatory mechanism to the low myeloid progenitor cells.	17961177
Fracture, Dentinogenesis Imperfecta	Stem Cell Exhaustion	Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice.	17967940
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Blood stem cell mobilization and collection in patients with chronic lymphocytic leukaemia: a nationwide analysis.	17968327
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Some reports suggest that blood stem cell mobilization is difficult in a proportion of patients with CLL.	17968327
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	One hundred and twenty-eight patients with CLL underwent blood stem cell mobilization during 1995-2005 in Finland.	17968327
Multiple Myeloma	Stem Cell Exhaustion	High-dose therapy with autologous stem-cell transplantation (HDT-ASCT) is now almost standard therapy for many patients with multiple myeloma, partly because of higher complete response (CR) rates.	17971591
Breast Carcinoma, Neoplasms	Stem Cell Exhaustion	The presence or preservation of CD34 antigen in four totally male breast carcinomas may be considered as a novel finding that supports a relationship between these tumours and the progenitor CD34-positive stem cells, committed to the organogenesis of mammary gland.	17972055
Breast Carcinoma	Stem Cell Exhaustion	In this context we hypothesise an origin of male breast carcinoma from the stem cells expressing or not the CD34 antigen according to their stage of differentiation.	17972055
Breast Carcinoma, Childhood Breast Carcinoma	Stem Cell Exhaustion	Basal-like breast carcinoma is an aggressive form of breast cancer, characterized by the absence of oestrogen receptor and HER2 expression, the presence of cytokeratin 5 and epidermal growth factor receptor expression, and by the up-regulation of stem cell regulatory genes.	17973239
Breast Carcinoma, Neoplasms	Stem Cell Exhaustion	We show here that tumour tissues expressing high levels of SLUG mRNA show a basal-like breast carcinoma phenotype and that such tumours also express high levels of stem cell-regulatory genes, ie CD133, Bmi1.	17973239
Childhood Breast Carcinoma	Stem Cell Exhaustion	These data indicate that SLUG gene expression is part of a hypoxia-induced genetic programme which sets up a basal/stem cell-like, aggressive phenotype in breast cancer cells.	17973239
Ductal Breast Carcinoma, Basal-Like Breast Carcinoma	Stem Cell Exhaustion	Further, we show that stem/progenitor cells, isolated from ductal breast carcinoma and from normal mammary gland as mammospheres, express SLUG, CD133, and Bmi1 mRNA and show a phenotype similar to that of basal-like breast carcinoma.	17973239
Mesenchymal Stem Cells	Stem Cell Exhaustion	Increased adipogenesis of osteoporotic human-mesenchymal stem cells (MSCs) characterizes by impaired leptin action.	17973271
Aspergillosis	Stem Cell Exhaustion	The patient died with fulminant aspergillosis before hematopoietic stem cell transplantation could be performed.	17973316
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Factors influencing spontaneous mobilization of CD34+ and CD133+ progenitor cells after myocardial infarction.	17973780
Acute myocardial infarction	Stem Cell Exhaustion	Bone marrow-derived circulating progenitor cells (BM-CPCs) are mobilized into adult peripheral blood (PB) during acute myocardial infarction (AMI) and may contribute to the regeneration of infarcted myocardium.	17973780
Scleroderma	Stem Cell Exhaustion	High-dose cyclophosphamide without stem cell rescue in scleroderma.	17974598
Scleroderma	Stem Cell Exhaustion	To investigate the safety and tolerability of high-dose cyclophosphamide without stem cell rescue in scleroderma.	17974598
Acute myocardial infarction	Stem Cell Exhaustion	Restoration of left ventricular synchronous contraction after acute myocardial infarction by stem cell therapy: new insights into the therapeutic implication of stem cell therapy for acute myocardial infarction.	17974698
Acute myocardial infarction	Stem Cell Exhaustion	To evaluate the effects of stem cell therapy on restoration of the left ventricular (LV) synchronous contraction in patients with acute myocardial infarction (AMI).	17974698
Toxic effect	Stem Cell Exhaustion	We performed a feasibility and toxicity pilot study of escalating activity of 90Y-ibritumomab tiuxetan followed by autologous stem cell transplantation (ASCT).	17979944
Refractory B-Cell Non-Hodgkin Lymphoma	Stem Cell Exhaustion	High activity 90Y-ibritumomab tiuxetan (Zevalin) with peripheral blood progenitor cells support in patients with refractory/resistant B-cell non-Hodgkin lymphomas.	17979944
Acute GVH disease	Stem Cell Exhaustion	Risk factors for acute graft-versus-host disease grades II-IV after reduced intensity conditioning allogeneic stem cell transplantation with unrelated donors: a single centre study.	17982493
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Comparable non-relapse mortality and survival after HLA-identical sibling blood stem cell transplantation with reduced or conventional-intensity preparative regimens for high-risk myelodysplasia or acute myeloid leukemia in first remission.	17982504
Metabolic Syndrome X, Coronary Arteriosclerosis	Stem Cell Exhaustion	Association between oxidative DNA damage and telomere shortening in circulating endothelial progenitor cells obtained from metabolic syndrome patients with coronary artery disease.	17983621
Avascular necrosis	Stem Cell Exhaustion	Patients receiving prolonged chemotherapy without stem cell transplant were at significantly greater risk of developing AVN than stem cell transplant recipients (P<0.00005).	17989709
Myeloid Leukemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Phase I/II study of gemtuzumab ozogamicin added to fludarabine, melphalan and allogeneic hematopoietic stem cell transplantation for high-risk CD33 positive myeloid leukemias and myelodysplastic syndrome.	17989720
Graft-vs-Host Disease	Stem Cell Exhaustion	Human leukocyte antigen (HLA) recombination, particularly multiple recombinations can produce novel haplotypes, thereby complicating donor-recipient selection and possibly inducing severe graft-vs-host disease (GVHD) after nonfully matched allogeneic hematopoietic stem cell transplantation.	17990988
Hematopoietic Neoplasms, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukemia (AML) is a morphologically diverse group of hematopoietic malignancies characterized by proliferation of immature cells that arise in the myeloid progenitor cells of the bone marrow.	17992463
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Time to engraftment following allogeneic stem cell transplantation is significantly longer in patients with myelodysplastic syndrome than with acute myeloid leukemia.	17994125
Pancytopenia, PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Patients with myelodysplastic syndrome (MDS) commonly present with pancytopenia, suggesting that the marrow stroma fails to support the growth of both malignant and normal stem cells.	17994125
Medulloblastoma	Stem Cell Exhaustion	Successful isolation and long-term establishment of a cell line with stem cell-like features from an anaplastic medulloblastoma.	17995922
Specialty Type - cancer, Medulloblastoma	Stem Cell Exhaustion	The 1603-MED possesses a high capacity for proliferation, CD133 expression, self-renewal and differentiation, thus indicating that anaplastic medulloblastoma contains a subpopulation of cancer stem cells as observed in classic medulloblastoma.	17995922
Lymphoma	Stem Cell Exhaustion	Five months after the initial diagnosis of lymphoma, the patient relapsed and was treated with high-dose BEAM (carmustine, etoposide, cytosine, arabinoside, melphalan) chemotherapy followed by CD34 stem-cell transplantations salvage therapy.	17997372
Eosinophilic pustular folliculitis	Stem Cell Exhaustion	Eosinophilic folliculitis following allogeneic peripheral blood stem cell transplantation: case report and review.	17997736
Adult Acute Eosinophilic Leukemia, Folliculitis	Stem Cell Exhaustion	We herein present a case of eosinophilic folliculitis that appeared in a 26-year-old woman 5 months after allogeneic peripheral blood stem cell transplantation as treatment for eosinophilic acute leukemia.	17997736
Cessation of life, Cytotoxic (disposition)	Stem Cell Exhaustion	Cell death is a normal response of cells to cytotoxic damage due to both internal and external threats, and this cell loss is normally countered by proliferation of neighboring cells and/or replacement of these cells from progenitor cell pools.	18000142
Neoplasms	Stem Cell Exhaustion	By generating phylogenetic trees as calculated from tumour cell sequences, the clonal evolution from a putative progenitor cell was elucidated and finally, the tumour cell migration pattern in disease progression was assessed by analyzing biopsies at different time points in relapsed tumours.	18000387
Acute myocardial infarction	Stem Cell Exhaustion	A meta-analysis of stem cell mobilization by granulocyte colony-stimulating factor in the treatment of acute myocardial infarction.	18000749
Immunocompromised Host	Stem Cell Exhaustion	The prognosis of old or immunocompromised patients with refractory or relapsing diffuse large-cell lymphoma (DLCL) is very poor as the current standard of salvage therapy with autologous stem cell transplantation (ASCT) is not feasible for most of them.	18005385
Tumor necrosis	Stem Cell Exhaustion	Role of soluble tumor necrosis factor-related apoptosis-inducing ligand concentrations after stem cell transplantation.	18005854
Graft-vs-Host Disease, Malignant Neoplasms	Stem Cell Exhaustion	Although stem cell transplantation (SCT) is being used for hematopoietic reconstitution following high-dose chemotherapy for malignancy, it involves certain serious transplant-related complications such as graft-versus-host disease (GVHD).	18005854
Chemotherapy-Induced Febrile Neutropenia, Specialty Type - cancer	Stem Cell Exhaustion	Authors have suggested that chemotherapy-induced neutropenia could represent a surrogate parameter of cancer stem cell response to treatment.	18006047
Atherosclerosis	Stem Cell Exhaustion	We analysed the possible protective role of human endothelial (EPCs) and smooth muscle (SPCs) progenitor cells on atherosclerosis development in apoE(-/-)RAG2(-/-) mice.	18006460
Plaque, Atherosclerotic	Stem Cell Exhaustion	Role of human smooth muscle cell progenitors in atherosclerotic plaque development and composition.	18006460
Barrett Esophagus	Stem Cell Exhaustion	In our case, the origin of the SmCC component could be explained by the numerous chromogranin A-positive cells observed in the Barrett's oesophagus or by the potential progenitor cells that may be located in the submucosal oesophageal gland ducts and the Barrett's metaplasia.	18008084
Neoplasms, Papillary glioneuronal tumor	Stem Cell Exhaustion	We report a further case of papillary glioneuronal tumor in a 12-year-old boy with immunohistochemical expression of PDGFRalpha, Olig2 and Nestin in support of a postulated origin of this tumor type from common progenitor cells in the subependymal plate.	18018482
Lymphocytosis	Stem Cell Exhaustion	Bioethical considerations of monoclonal B-cell lymphocytosis: donor transfer after haematopoietic stem cell transplantation.	18021093
Infection, Hematological Disease	Stem Cell Exhaustion	Infections caused by mycobacterium tuberculosis in patients with hematological disorders and in recipients of hematopoietic stem cell transplant, a twelve year retrospective study.	18021401
Hematological Disease, Tuberculosis	Stem Cell Exhaustion	Tuberculous infections in patients with hematological disorders and hematopoietic stem cell transplant vary in incidence, complications and response to treatment.	18021401
Hematological Disease, Tuberculosis	Stem Cell Exhaustion	A retrospective study of patients with various benign and malignant hematological disorders and recipients of hematopoietic stem cell transplant who were treated at Riyadh Armed Forces Hospital, Saudi Arabia between January 1991 and December 2002 and who developed tuberculous infections was conducted.	18021401
Hematological Disease, Tuberculosis	Stem Cell Exhaustion	Tuberculous infections occurred in eighteen patients with hematological disorders and hematopoietic stem cell transplant.	18021401
Hematological Disease, Tuberculosis	Stem Cell Exhaustion	Tuberculous infections cause significant morbidity and mortality in patients with various hematological disorders and in recipients of hematopoietic stem cell transplant.	18021401
Multiple Myeloma	Stem Cell Exhaustion	Beta-2-microglobulin level predicts outcome following autologous hematopoietic stem cell transplantation in patients with multiple myeloma.	18022010
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Despite the widespread use of high-dose therapy combined with autologous hematopoietic stem cell transplantation (autoHSCT), the outcomes of multiple myeloma (MM) treatment remain variable.	18022010
Multiple Myeloma	Stem Cell Exhaustion	Veno-occlusive disease of the liver after high-dose cytoreductive therapy with busulfan and melphalan for autologous blood stem cell transplantation in multiple myeloma patients.	18022574
Comorbidity, Communicable Diseases	Stem Cell Exhaustion	After adjusting for the HCT comorbidity index, relapse risk, patient age, stem cell source, preparative regimen, previous cytomegalovirus (CMV) infection, and sex mismatch of donor and recipient in multivariate analysis, we found no statistically significant differences between unrelated and related HCT recipients in terms of risk of nonrelapse mortality (NRM; hazard ratio [HR] = 0.98; 95% confidence interval = 0.6-1.6; P = .94), relapse (HR = 1.04; 95% confidence interval = 0.7-1.5; P = .82), or overall mortality (HR = 0.99; 95% confidence interval = 0.7-1.4; P = .94).	18022580
Amyloidosis	Stem Cell Exhaustion	High-dose melphalan and autologous stem cell transplantation is currently the treatment of choice for selected patients with AL amyloidosis; however, new treatments are needed for patients who are ineligible for or relapse after this procedure.	18024372
Multiple Myeloma	Stem Cell Exhaustion	As new therapeutic options for multiple myeloma (MM) emerge, identification of biological markers which could predict clinical response to standard treatment with high-dose melphalan (HDM) supported by autologous stem cell transplantation (ASCT) becomes more important.	18024399
Lupus Erythematosus	Stem Cell Exhaustion	Bone marrow-derived mesenchymal stem cells induce both polyclonal expansion and differentiation of B cells isolated from healthy donors and systemic lupus erythematosus patients.	18024418
Lupus Erythematosus	Stem Cell Exhaustion	We studied the influence of bone marrow mesenchymal stem cells on highly purified B-cell subsets isolated from healthy donors and total B cells from pediatric systemic lupus erythematosus patients.	18024418
Autoimmune Diseases	Stem Cell Exhaustion	This study casts important questions on bone marrow mesenchymal stem cells as a therapeutic tool in autoimmune diseases in which B-cell activation is crucially implicated in the pathogenesis of the disease.	18024418
Multiple Myeloma	Stem Cell Exhaustion	Stem cell transplantation in multiple myeloma.	18024645
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	This phase II trial evaluated the safety and efficacy of combining yttrium-90 (90Y) ibritumomab tiuxetan with high-dose carmustine, cytarabine, etoposide, and melphalan (BEAM) and autologous stem-cell transplantation in patients with non-Hodgkin's lymphoma who were considered ineligible for total-body irradiation because of older age or prior radiotherapy.	18025438
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Between May 2002 and January 2006, 14 days before autologous stem-cell transplantation, 41 patients with non-Hodgkin's lymphoma received standard-dose 90Y ibritumomab tiuxetan (14.8 MBq/kg [0.4 mCi/kg]) followed by high-dose BEAM.	18025438
Toxic effect	Stem Cell Exhaustion	Adding 90Y ibritumomab tiuxetan to high-dose BEAM with autologous stem-cell transplantation is feasible and has a toxicity and tolerability profile similar to that observed with BEAM alone.	18025438
Childhood Breast Carcinoma	Stem Cell Exhaustion	Randomized trial of high-dose chemotherapy with autologous peripheral-blood stem-cell support compared with standard-dose chemotherapy in women with metastatic breast cancer: NCIC MA.16.	18025439
mecarzole, Childhood Breast Carcinoma	Stem Cell Exhaustion	We conducted a multicenter, randomized trial to compare progression-free survival (PFS), overall survival (OS), and quality of life in women with metastatic breast cancer (MBC) receiving high-dose chemotherapy plus autologous stem-cell transplantation (ASCT; HDCT) compared with standard-dose therapy.	18025439
Cytomegalovirus Infections	Stem Cell Exhaustion	In order to evaluate whether we could predict reactivation of CMV by monitoring the number of CMV-specific cytotoxic T-lymphocytes (CTL), tetramer analysis was performed in 37 patients who underwent hematopoietic stem cell transplantation (HSCT).	18026143
Platinum-Sensitive Ovarian Carcinoma	Stem Cell Exhaustion	High-dose melphalan and autologous stem cell transplantation as consolidation treatment in patients with chemosensitive ovarian cancer: results of a single-institution randomized trial.	18026149
PAFAH1B1 wt Allele, leukemia	Stem Cell Exhaustion	(i) L-selectin is defective in the stem cell compartment of MDS and sAML, whereas ICAM1 is overexpressed; (ii) the ratio of their expression has a prognostic role; and (iii) a ratio <1 significantly predicts progression to overt leukaemia in MDS patients.	18028430
PAFAH1B1 wt Allele	Stem Cell Exhaustion	In a three-colour flow cytometric assay, we evaluated the expression of L-selectin and ICAM1 on CD34+ blast cells from the bone marrow (BM) of 66 MDS patients; for the purpose of comparison CD34+ blast cells of 18 sAML and CD34+ stem cells of 17 normal donors were also analysed.	18028430
PMF Regimen	Stem Cell Exhaustion	Allogeneic stem cell transplantation (SCT) is the only curative therapy for PMF.	18032975
Neoplasms, Glioblastoma	Stem Cell Exhaustion	Tumor cells with stem cell-like properties can be cultured from human glioblastomas by using conditions that select for the expansion of neural stem cells.	18037961
Glioblastoma Multiforme Pathway, Adult Glioblastoma	Stem Cell Exhaustion	We generated cell lines from glioblastoma specimens with the goal to obtain model systems for glioma stem cell biology.	18037961
Adult Glioblastoma	Stem Cell Exhaustion	The generation of another distinct cluster of cell lines showing similarly homogeneous profiling but restricted stem cell properties suggests that different phenotypes exist, each of which may lead to the typical appearance of glioblastoma.	18037961
Myeloid Leukemia	Stem Cell Exhaustion	Thus, overexpression of sPRDM16 induces abnormal growth of stem cells and progenitors and cooperates with disruption of the p53 pathway in the induction of myeloid leukemia.	18037989
leukemia, SET gene	Stem Cell Exhaustion	Transgenic expression of the abnormal products of acute myeloid leukemia-associated (AML-associated) primary chromosomal translocations in hematopoietic stem/progenitor cells initiates leukemogenesis in mice, yet additional mutations are needed for leukemia development.	18037989
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Long-term results of a phase-I/II study of sequential high-dose chemotherapy with autologous stem cell transplantation in the initial treatment of aggressive non-Hodgkin's lymphoma.	18038870
Graft-vs-Host Disease	Stem Cell Exhaustion	Pharmacokinetics of oral posaconazole in allogeneic hematopoietic stem cell transplant recipients with graft-versus-host disease.	18041883
Graft-vs-Host Disease, Mycoses	Stem Cell Exhaustion	To analyze the pharmacokinetics of posaconazole administered as prophylaxis for invasive fungal infections in recipients of hematopoietic stem cell transplants (HSCTs) who have graft-versus-host disease (GVHD).	18041883
Liver Dysfunction, Mycoses	Stem Cell Exhaustion	To assess the effectiveness and tolerability of caspofungin as primary prophylaxis against invasive fungal infections in stem cell transplant recipients who are poor candidates for triazole or lipid amphotericin B prophylaxis due to renal or hepatic dysfunction, and to determine whether any patient characteristics are independently associated with an increased risk of breakthrough invasive fungal infection during caspofungin prophylaxis.	18041885
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	The DNA hypomethylating agent azacitidine was approved by the United States Food and Drug Administration after the drug demonstrated superiority over the best supportive care for treatment of myelodysplastic syndrome in patients unable to undergo stem cell transplantation.	18041893
Childhood Breast Carcinoma	Stem Cell Exhaustion	Circulating endothelial progenitor cells correlate to stage in patients with invasive breast cancer.	18043899
Bronchiolitis Obliterans	Stem Cell Exhaustion	Living-donor lobar lung transplantation for broncho-bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation: does bronchiolitis obliterans recur in transplanted lungs?	18055347
Bronchiolitis Obliterans	Stem Cell Exhaustion	We report a successful case of living-donor lobar lung transplantation (LDLLT) for therapy-resistant broncho-bronchiolitis obliterans (BBO) after allogeneic hematopoietic stem cell transplantation (HSCT).	18055347
BCR gene	Stem Cell Exhaustion	Five years later, she relapsed with ALL and was treated with chemotherapy following stem cell rescue and donor lymphocyte infusion from the original BMT donor.	18055347
Aspergillus Galactomannan Antigen Test	Stem Cell Exhaustion	False-positive Aspergillus galactomannan antigenaemia after haematopoietic stem cell transplantation.	18055488
Exudative age-related macular degeneration	Stem Cell Exhaustion	Circulating hematopoietic stem cells in patients with neovascular age-related macular degeneration.	18055794
Choroidal Neovascularization, methyldopa	Stem Cell Exhaustion	Circulating hematopoietic stem cells (HSCs) appear to have roles in the formation of choroidal neovascularization (CNV) in age-related macular degeneration (AMD).	18055794
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	The T-LBL/ALL-GOELAL02 study evaluated the impact of randomized reinduction chemotherapy against intensified conditioning followed by autologous stem cell transplantation (ASCT), after an induction regimen of the type used for acute lymphoblastic leukemia (ALL).	18055985
Neoplasms, Glioblastoma	Stem Cell Exhaustion	Stem cell marker nestin and c-Jun NH2-terminal kinases in tumor and peritumor areas of glioblastoma multiforme: possible prognostic implications.	18056172
Neoplasms	Stem Cell Exhaustion	It has been hypothesized that brain tumors are derived from stem cell or transiently dividing precursor transformation.	18056172
Glioblastoma	Stem Cell Exhaustion	This study analyzes stem cell marker nestin and JNK expression in glioblastoma multiforme (GBM) and peritumor tissue and assesses their possible prognostic implications.	18056172
Graft-vs-Host Disease	Stem Cell Exhaustion	Gastrointestinal graft-versus-host disease (GVHD) is a common and potentially life-threatening complication after allogeneic hematopoietic stem-cell transplantation (HSCT).	18057227
Angina Pectoris	Stem Cell Exhaustion	The effects of external counter pulsation therapy on circulating endothelial progenitor cells in patients with angina pectoris.	18057883
Rett Syndrome	Stem Cell Exhaustion	A case report: bone marrow mesenchymal stem cells from a Rett syndrome patient are prone to senescence and show a lower degree of apoptosis.	18059018
Myeloid Leukemia, Toxoplasmosis, Cerebral	Stem Cell Exhaustion	Here we describe a 56-years-old patient who developed cerebral toxoplasmosis after receiving stem-cell transplantation treatment for acute myeloic leukemia, and we discuss the clinical features, differential diagnoses and therapeutic strategies.	18060332
Coronary Arteriosclerosis	Stem Cell Exhaustion	Our objective was to develop and assess a novel endogenous progenitor cell (EPC) assay based on aldehyde dehydrogenase (ALDH) activity, and to define the relationship of ALDH-bright (ALDH(br)) cells with previously defined EPCs, patient age, and extent of coronary artery disease.	18061073
Ischemic stroke	Stem Cell Exhaustion	Level and value of circulating endothelial progenitor cells in patients after acute ischemic stroke.	18063830
Ischemia	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) migrate from bone marrow to systemic circulation in response to tissue ischemia where they differentiate into mature endothelial cells for angiogenesis in situ.	18063830
Hematologic Neoplasms	Stem Cell Exhaustion	Outcomes after hematopoietic stem-cell transplantation for hematologic malignancies in patients with or without advance care planning.	18065735
Specialty Type - cancer, American College of Physicians	Stem Cell Exhaustion	In patients undergoing hematopoietic stem-cell transplantation (HSCT), an aggressive but possibly curative procedure for cancer, encouraging engagement in ACP is difficult.	18065735
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Fludarabine and treosulfan: a novel modified myeloablative regimen for allogeneic hematopoietic stem-cell transplantation with effective antileukemia activity in patients with acute myeloid leukemia and myelodysplastic syndromes.	18067010
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic stem-cell transplantation (SCT) is potentially curative treatment for AML and MDS.	18067010
Hematologic Neoplasms, Failure	Stem Cell Exhaustion	Paclitaxel and filgrastim for hematopoietic progenitor cell mobilization in patients with hematologic malignancies after failure of a prior mobilization regimen.	18067011
Polycythemia Vera	Stem Cell Exhaustion	Polycythemia vera (PV) is a clonal stem cell disorder characterized by an excessive erythrocyte production.	18068534
Cardiotoxicity	Stem Cell Exhaustion	Subacute cardiac toxicity following autologous haematopoietic stem cell transplantation in patients with normal cardiac function.	18070952
Cardiotoxicity	Stem Cell Exhaustion	To investigate subacute cardiac toxicity in patients with normal baseline cardiac function following autologous haematopoietic stem cell transplantation.	18070952
Cardiotoxicity	Stem Cell Exhaustion	Subacute cardiac toxicity is common after autologous haematopoietic stem cell transplantation, even in patients with apparently normal left ventricular function.	18070952
Hodgkin Disease	Stem Cell Exhaustion	Intensive conditioning regimen of etoposide (VP-16), cyclophosphamide and carmustine (VCB) followed by autologous hematopoietic stem cell transplantation for relapsed and refractory Hodgkin's lymphoma.	18071290
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	Several high-dose therapy regimens are used for autologous hematopoietic stem cell transplantation (auto-HSCT) for relapsed and refractory Hodgkin's lymphoma (HL) with variable disease response.	18071290
Neoplasms	Stem Cell Exhaustion	The picture may confirm the theory that multiple GTs develop in association with multifocal proliferation of perivascular stem cells, as well as that their ability to penetrate into the lumen of large vessels gives origin to satellite tumors, which are not necessarily metastatic.	18074867
Prostate carcinoma, Benign prostatic hypertrophy	Stem Cell Exhaustion	The association of prostate stem cell antigen (PSCA) mRNA expression and subsequent prostate cancer risk in men with benign prostatic hyperplasia following transurethral resection of the prostate.	18076024
Benign prostatic hypertrophy	Stem Cell Exhaustion	Prior data showed prostate stem cell antigen (PSCA) mRNA expression in benign prostatic hyperplasia (BPH) tissues.	18076024
Neoplasms	Stem Cell Exhaustion	It is therefore possible that a tumor originating in an immature or uncommited adenohypophysial stem cell may later differentiate into different cell types due to a combination of certain specific transcriptional factors.	18079591
Congestive heart failure, Amyloidosis	Stem Cell Exhaustion	[Long-term survival after autologous peripheral blood stem cell transplantation in a patient with primary AL amyloidosis complicating congestive heart failure].	18080505
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We present a case of AML accompanied by oral chronic GVHD in a 55-year-old man after allogeneic stem cell transplantation.	18080511
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Potential of dendritic-cell immunotherapy for relapse after allogeneic hematopoietic stem cell transplantation, shown by WT1 peptide- and keyhole-limpet-hemocyanin-pulsed, donor-derived dendritic-cell vaccine for acute myeloid leukemia.	18081032
Nephroblastoma, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 58-year-old woman received Wilms' tumor 1 (WT1) peptide- and keyhole limpet hemocyanin (KLH)-pulsed, donor-derived dendritic cell (DC) vaccination for AML relapse after allogeneic stem cell transplantation.	18081032
Coronary heart disease	Stem Cell Exhaustion	Functional impairment of hematopoietic progenitor cells in patients with coronary heart disease.	18081701
Graft-vs-Host Disease, Acute GVH disease, Tumor necrosis	Stem Cell Exhaustion	Macrophage migration inhibitory factor (MIF) may play an important role in the pathogenesis of acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT), as MIF plays an important role to regulate the production of tumor necrosis factor-alpha (TNF-alpha), one of the inflammatory cytokines which induces and exacerbates aGVHD.	18081874
Inflammation	Stem Cell Exhaustion	Intracoronary injection of mBMC in patients with AMI induces a marked short-term inflammatory response, but a slightly reduced inflammation after 3 months which may have implications for the timing of stem cell transplantation in AMI.	18082489
Ischemia	Stem Cell Exhaustion	Fifteen patients suffering from critical lower limb ischemia received subcutaneous injections of recombinant human granulocyte colony-stimulating factor (G-CSF) to mobilize progenitor cells, and PB-MNCs were harvested and transplanted directly into the ischemic limb.	18083329
Adenoid Cystic Carcinoma, Adenocarcinoma	Stem Cell Exhaustion	We studied the expression of several myoepithelial and basal/stem cell markers (smooth muscle actin, calponin, smooth muscle myosin heavy chain, metallothionein, maspin, and p63) by immunohistochemistry in 23 adenoid cystic carcinoma and 24 polymorphous low-grade adenocarcinoma, to identify the most useful marker or combination of markers that may help their diagnoses.	18084258
Stem Cell Factor	Stem Cell Exhaustion	The expression of KIT and PDGFRA and their respective ligands, stem cell factor (SCF) and PDGFA, was assessed by immunohistochemistry.	18084259
Neoplasms	Stem Cell Exhaustion	The patient had an aggressive clinical course, in which the tumor cells metastasized to the regional lymph nodes a few months after surgical removal of the primary lesion, and skin nodules recurred on the face despite intensive polychemotherapy, followed by autologous peripheral blood stem cell transplantation.	18086594
Vascular Diseases	Stem Cell Exhaustion	In adults, circulating endothelial progenitor cells (EPCs) participate in vascular repair, and EPC numbers and function inversely correlate with the risk of developing vascular disease.	18086900
Electrocardiogram: myocardial infarction (finding), Ventricular Dysfunction, Left	Stem Cell Exhaustion	[Intracoronary transfer autologous bone marrow stem cells can improve cardiac function in patients with left ventricular dysfunction after myocardial infarction].	18087557
Electrocardiogram: myocardial infarction (finding), Myocardial dysfunction	Stem Cell Exhaustion	To evaluate the efficacy of intracoronary transfer of autologous bone marrow mononuclear stem cells in patients with heart dysfunction after myocardial infarction.	18087557
Anterior myocardial infarction	Stem Cell Exhaustion	Forty-two patients with anterior myocardial infarction [BMSC(bone marrow mononuclear stem cells) group: 13 cases; control group: 29 cases] were treated by standard percutaneous coronary intervention (PCI) and medical therapy.	18087557
Alzheimers Disease	Stem Cell Exhaustion	To study whether neural stem cell can reactivate or rescue functions of impaired neurons in the human aging and neurodegenerating brain, we co-cultured postmortem slices from Alzheimer patients and control participants with rat embryonic day 14 (E14) neural stem cells.	18088384
Alzheimers Disease	Stem Cell Exhaustion	Neural stem cells improve neuronal survival in cultured postmortem brain tissue from aged and Alzheimer patients.	18088384
Splenomegaly	Stem Cell Exhaustion	PB cytogenetic studies resulted in at least two analyzable metaphases in 142 of the 242 study cases (59%); in univariate analysis, this was predicted by the specific clinical diagnosis (P < 0.0001), presence and degree of circulating myeloid progenitor cells or blasts of any lineage (P < 0.0001), higher leukocyte count (P < 0.001), lower platelet count (P = 0.003), lower hemoglobin level (P = 0.002), and presence of palpable splenomegaly (P = 0.002).	18088399
Acute lymphocytic leukemia, Primary Myelofibrosis, Leukemia, Myelocytic, Acute, PMF Regimen	Stem Cell Exhaustion	In multivariable analysis, only the presence of circulating myeloid progenitor cells or blasts sustained significance and this was consistent with the high yield rates seen in primary myelofibrosis (PMF) (80%), post-PV/ET PMF (85%), acute myeloid leukemia (76%), and acute lymphoblastic leukemia (80%) in contrast with the low rates seen in ET (0%) and PV (2%).	18088399
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Dose-escalated CHOP and tailored intensification with IFE according to early response and followed by BEAM/autologous stem-cell transplantation in poor-risk aggressive B-cell lymphoma: a prospective study from the GEL-TAMO Study Group.	18088400
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	The role of high-dose therapy and autologous stem-cell transplantation (HDT/ASCT) in the up-front treatment of poor-risk aggressive lymphoma is still unknown.	18088400
Acute myocardial infarction	Stem Cell Exhaustion	Stem cells mobilization in acute myocardial infarction (stem-AMI trial): preliminary data of a perspective, randomized, single blind trial.	18091641
Thrombocythemia, Essential	Stem Cell Exhaustion	Essential thrombocythemia (ET) is thought to reflect transformation of a multipotent hematopoietic stem cell, but its molecular pathogenesis remains obscure.	18094555
PAFAH1B1 wt Allele	Stem Cell Exhaustion	The increased number of functional endothelial progenitor cells in MDS strengthens the rationale for therapeutic interventions aimed at restoring a normal interaction between hematopoietic progenitors and marrow microenvironment.	18094717
Blood Coagulation Disorders	Stem Cell Exhaustion	Improved peripheral blood stem cell collection following plasma exchange in a patient with elevated viscosity and coagulopathy.	18095304
Blood Coagulation Disorders	Stem Cell Exhaustion	We report a case of improved CD34+ cell yields from peripheral blood stem cell (PBSC) collection following therapeutic plasma exchange (TPE) in a patient with elevated viscosity and coagulopathy.	18095304
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Overexpression of B-cell lymphoma 2 (bcl-2) protein is a simple biological adverse prognostic factor that could delimit the poor prognosis population candidate for improvement with high-dose therapy and autologous stem-cell transplantation (ASCT) in diffuse large B-cell lymphoma (DLBCL).	18096567
Uterine Neoplasms, Stromal tumor of ovary	Stem Cell Exhaustion	Uterine tumors resembling ovarian sex-cord tumors (UTROSCT) are very rare, usually benign uterine tumors, and are probably derived from uterine mesenchymal stem cells.	18156976
Squamous Differentiation	Stem Cell Exhaustion	Given the morphological and immunohistochemical findings, we suggest that PSSCIS arises from a bidirectional stem cell capable of both squamous and glandular differentiation.	18156986
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Inappropriate Notch activity and limited mesenchymal stem cell plasticity in the bone marrow of patients with myelodysplastic syndromes.	18158566
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Furthermore, there was a marked reduction in the plasticity of mesenchymal stem cells of MDS patients compared with those of normal marrow donors, in neurogenic and adipogenic differentiation ability and hematopoiesis supporting capacity in vitro.	18158566
PAFAH1B1 wt Allele	Stem Cell Exhaustion	In this study, we have examined the relative frequencies of stem and progenitor cell subsets of MDS and normal hematopoietic cells growing on stromal cell layers established from MDS patients and from normal donors.	18158566
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Moreover, a soluble Notch ligand (Jagged-1 protein) was an inhibitor of day-35-42 CAFC when normal hematopoietic cells were cultured with normal or MDS stromal cells, but was unable to inhibit MDS stem and early progenitor cell growth (day-35-42 CAFC) on pre-established stromal layers.	18158566
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	These results are consistent with the hypothesis that when alterations are present in the myelodysplastic stroma environment along with intrinsic changes in a hematopoietic stem/progenitor cell clone, both factors might equally contribute to the abnormal hematopoiesis in MDS.	18158566
MYELODYSPLASTIC SYNDROME, Acute leukemia	Stem Cell Exhaustion	A prognostic score for patients with acute leukemia or myelodysplastic syndromes undergoing allogeneic stem cell transplantation.	18158958
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Acute leukemia	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (SCT) has the potential to cure patients with acute leukemia or myelodysplastic syndromes (MDS), but a number of prognostic factors can influence the outcome of transplantation.	18158958
Lymphoma, Follicular	Stem Cell Exhaustion	Long-term outcomes of autologous stem cell transplantation for follicular non-Hodgkin lymphoma: effect of histological grade and Follicular International Prognostic Index.	18158959
Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	Although results of autologous stem cell transplantation (SCT) for recurrent follicular non-Hodgkin lymphoma (NHL) have been previously reported, the long-term results and evaluation of prognostic factors in a large patient population receiving this therapy are difficult to find in the literature.	18158959
AIDS-Associated Nephropathy, AIDS Malignancy Consortium	Stem Cell Exhaustion	Dose-reduced busulfan, cyclophosphamide, and autologous stem cell transplantation for human immunodeficiency virus-associated lymphoma: AIDS Malignancy Consortium study 020.	18158962
Bronchiolitis Obliterans	Stem Cell Exhaustion	Recipient NOD2/CARD15 variants: a novel independent risk factor for the development of bronchiolitis obliterans after allogeneic stem cell transplantation.	18158963
Bronchiolitis Obliterans, bottle - unit dose	Stem Cell Exhaustion	Bronchiolitis obliterans (BO) is a serious complication after allogeneic stem cell transplantation.	18158963
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Oral chronic graft-versus-host disease (cGVHD) is a significant and serious complication following allogeneic hematopoietic stem cell transplantation (HSCT).	18158967
Multiple Myeloma	Stem Cell Exhaustion	Higher infused lymphocyte dose predicts higher lymphocyte recovery, which in turn, predicts superior overall survival following autologous hematopoietic stem cell transplantation for multiple myeloma.	18158968
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) is the standard of care for patients with multiple myeloma (MM) younger than 70 years.	18158968
Kidney Failure, Acute	Stem Cell Exhaustion	Acute renal failure after nonmyeloablative stem cell transplantation in adults.	18158969
Kidney Failure, Acute	Stem Cell Exhaustion	Acute renal failure (ARF) after myeloablative stem cell transplantation (SCT) is a well-established problem.	18158969
Zygomycosis, Adult Myelodysplastic Syndrome, Aspergillosis	Stem Cell Exhaustion	A 52-year-old man underwent haematopoietic stem-cell transplant for myelodysplastic syndrome; after treatment with voriconazole for invasive aspergillosis, he was diagnosed with invasive zygomycosis caused by Rhizopus microsporus.	18161258
Mantle cell lymphoma	Stem Cell Exhaustion	A phase II clinical trial of intensive chemotherapy followed by consolidative stem cell transplant: long-term follow-up in newly diagnosed mantle cell lymphoma.	18162124
Oropharyngeal pain, Tumor necrosis	Stem Cell Exhaustion	Oral mucositis-related oropharyngeal pain and correlative tumor necrosis factor-alpha expression in adult oncology patients undergoing hematopoietic stem cell transplantation.	18164921
Gastrointestinal mucositis, Usual Severity Pain	Stem Cell Exhaustion	Oral mucositis is the most common sequela of conditioning chemotherapy (CT) for hematopoietic stem cell transplantation (HSCT) and is the principal cause of most of the associated pain.	18164921
Aspergillosis	Stem Cell Exhaustion	Patients with suspected invasive aspergillosis were identified by aspergillosis-related ICD-9 codes assigned to hematopoietic stem cell transplant recipients and solid organ transplant recipients at a single hospital from April 1, 2001, through January 31, 2005.	18171183
Hematologic Neoplasms	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) is a curative treatment option for hematological malignancies, but this treatment can be associated with a mortality risk.	18173061
Cessation of life	Stem Cell Exhaustion	Death occurred at a median of 85 days post transplantation (range 2-1825 days); 36 (55%) died within the first 100 days post stem cells infusion.	18173061
Cytomegaloviral pneumonia	Stem Cell Exhaustion	Fatal CMV pneumonia in an autologous stem cell transplant recipient previously treated with alemtuzumab.	18173065
Hematopoietic Neoplasms	Stem Cell Exhaustion	Of 13 patients, 12 had background disease, and six of these were hematopoietic malignancies; four of these patients were hematopoietic stem cell transplant (HSCT) recipients.	18173598
Systemic Scleroderma, Sample Size Calculation	Stem Cell Exhaustion	Heterogeneous data have been reported regarding the detection and number of circulating endothelial progenitor cells (EPCs) in systemic sclerosis (SSc).	18174219
Hepatic Veno-Occlusive Disease, Esophageal Varices	Stem Cell Exhaustion	Hepatic veno-occlusive disease followed by esophageal varix rupture after hematopoietic stem cell transplantation in a 4-year-old boy with stage 4 neuroblastoma.	18176184
Hepatic Veno-Occlusive Disease	Stem Cell Exhaustion	Hepatic veno-occlusive disease (HVOD) is one of the major potential complications associated with high-dose chemotherapy with stem cell transplantation in children.	18176184
Disseminated neuroblastoma, Intestinal hemorrhage NOS, Esophageal Varices	Stem Cell Exhaustion	Here we report a case of a 4-year-old boy with stage 4 neuroblastoma with potentially fatal HVOD followed by esophageal varix rupture and massive intestinal bleeding after high-dose chemotherapy with autologous peripheral blood stem cell transplantation.	18176184
Toxic effect	Stem Cell Exhaustion	A prospective randomized study using N-acetyl-L-cysteine for early liver toxicity after allogeneic hematopoietic stem cell transplantation.	18176610
Hepatic Veno-Occlusive Disease, Toxic effect, Venoocclusive disease	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (ASCT) and its conditioning with chemoradiotherapy often results in liver toxicity, the most severe form being veno-occlusive liver disease (VOD).	18176610
Cystitis	Stem Cell Exhaustion	BK-viruria and haemorrhagic cystitis are more frequent in allogeneic haematopoietic stem cell transplant patients receiving full conditioning and unrelated-HLA-mismatched grafts.	18176615
CLTC gene, Cystitis	Stem Cell Exhaustion	The influence of conditioning regimen, donor background and HLA matching on development of BK virus (BKV)-associated haemorrhagic cystitis (HC) was examined in 175 allogeneic haematopoietic stem cell transplant (HSCT) patients, undergoing 179 HSCT events.	18176615
Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic GVHD is a significant complication following allogeneic hematopoietic stem cell transplantation; however, the clinical characteristics of chronic GVHD following cord blood transplantation (CBT) in adults have not been well described.	18176617
Neoplasms	Stem Cell Exhaustion	The study indicated that the stem cell product used was safe in the short and over long term, by absence of tumour formation.	18181952
Liver diseases	Stem Cell Exhaustion	Evidence is growing in support of the role of stem cells as an attractive alternative in treatment of liver diseases.	18181952
Chronic liver disease	Stem Cell Exhaustion	Recently, we have demonstrated the feasibility and safety of infusing CD34(+) adult stem cells; this was performed on five patients with chronic liver disease.	18181952
Angioimmunoblastic Lymphadenopathy	Stem Cell Exhaustion	High-dose therapy and autologous stem-cell transplantation in angioimmunoblastic lymphoma: complete remission at transplantation is the major determinant of Outcome-Lymphoma Working Party of the European Group for Blood and Marrow Transplantation.	18182664
Carcinogenic Chlorinated Hydrocarbon	Stem Cell Exhaustion	Twelve cases of CHC were studied by immunohistochemistry for hepatocytic (hepPar1, alpha-fetoprotein), cholangiocytic cytokeratin [(CK) 7, CK19], hepatic progenitor cell (OV-6), haematopoietic stem cell (c-kit, CD34), as well as CD45 and chromogranin-A markers.	18184271
Carcinogenic Chlorinated Hydrocarbon	Stem Cell Exhaustion	Data suggest that most CHC arise from hepatic progenitor cells (HPCs).	18184271
Encephalopathy, CTCAE 5.0	Stem Cell Exhaustion	Both should be considered in a post-hematopoietic stem cell transplant patient who develops a progressive encephalopathy when more common etiologies are not found.	18186895
Histiocytosis, Langerhans-Cell	Stem Cell Exhaustion	Successful treatment of refractory Langerhans cell histiocytosis by allogeneic peripheral blood stem cell transplantation.	18186896
Kidney Failure	Stem Cell Exhaustion	Association between endothelial progenitor cell depletion in blood and mild-to-moderate renal insufficiency in stable angina.	18187495
Coronary Arteriosclerosis	Stem Cell Exhaustion	Low blood counts of CD34/kinase-insert domain receptor double-positive cells (CD34(+)/KDR(+) cells)-a leukocytes subpopulation enriched for bone marrow-derived endothelial progenitor cells (EPC)- predict adverse outcomes in coronary artery disease (CAD).	18187495
Multiple Myeloma	Stem Cell Exhaustion	Chimerism and T-cell receptor repertoire analysis after unrelated cord blood transplantation with a reduced-intensity conditioning regimen following autologous stem cell transplantation for multiple myeloma.	18190473
Pregnancy Complications, Infectious, Chronic graft-versus-host disease	Stem Cell Exhaustion	Infectious complications in chronic graft-versus-host disease: a retrospective study of 145 recipients of allogeneic hematopoietic stem cell transplantation with reduced- and conventional-intensity conditioning regimens.	18194371
Stable chronic Graft vs Host Disease, Pregnancy Complications, Infectious, Chronic graft-versus-host disease	Stem Cell Exhaustion	To assess infectious complications associated with chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (HSCT) with reduced- and conventional-intensity conditioning regimens (RIC, n=91; CIC, n=54, respectively), we retrospectively analyzed data from 145 consecutive patients with cGVHD after allogeneic HSCT from a human leukocyte antigen-matched related or unrelated donor.	18194371
Lymphoma, Non-Hodgkin, Multiple Myeloma	Stem Cell Exhaustion	Prospective randomized comparative observation of single- versus split-dose lenograstim to enhance engraftment after autologous stem cell transplantation in patients with multiple myeloma or non-Hodgkin's lymphoma.	18194384
Multiple Myeloma	Stem Cell Exhaustion	Extramedullary relapses after allogeneic non-myeloablative stem cell transplantation in multiple myeloma patients do not negatively affect treatment outcome.	18195681
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Recent literature suggests that after non-myeloablative allogeneic (NMA) stem cell transplantation (SCT), the incidence of extramedullary (EM) relapse in multiple myeloma (MM) patients is increased and that these relapses have a poor prognosis.	18195681
Metabolic Syndrome X	Stem Cell Exhaustion	Prevalence of metabolic syndrome in long-term survivors of hematopoietic stem cell transplantation.	18195686
Metabolic Syndrome X, Mitral Valve Stenosis	Stem Cell Exhaustion	Our purpose was to determine the prevalence and features of metabolic syndrome (MS) in a series of long-term hematopoietic stem cell transplantation (HSCT) survivors.	18195686
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Time of relapse after initial therapy significantly adds to the prognostic value of the IPI-R in patients with relapsed DLBCL undergoing autologous stem cell transplantation.	18195687
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome, Acute leukemia	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) constitutes a heterogeneous group of hematopoietic stem cell disorder characterized by peripheral blood cytopenia(s), in the presence of hypercellular bone marrow with features of ineffective hematopoiesis, and susceptibility to acute leukemia (AL).	18199987
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic graft-versus-host disease (cGVHD) is a common but serious complication of allogeneic haematopoietic stem cell transplantation (HSCT).	18199988
Pancreatic carcinoma	Stem Cell Exhaustion	Improved lentiviral transduction of human mesenchymal stem cells for therapeutic intervention in pancreatic cancer.	18202717
Specialty Type - cancer	Stem Cell Exhaustion	Genetic modification of human bone marrow mesenchymal stem cells (MSC) is highly valuable for their exploitation in basic science and therapeutic applications, for example in cancer.	18202717
Amyloidosis	Stem Cell Exhaustion	Troponin T level as an exclusion criterion for stem cell transplantation in light-chain amyloidosis.	18203009
Amyloidosis	Stem Cell Exhaustion	The efficacy of stem cell transplantation in amyloidosis largely is determined by treatment-related mortality rates (range, 11-25%).	18203009
Pterygium	Stem Cell Exhaustion	Pterygium is an invasive and highly vascularized growth, thought to arise from activated and proliferating limbal epithelial stem cells.	18203080
Urinary Stress Incontinence	Stem Cell Exhaustion	1-year follow-up of autologous muscle-derived stem cell injection pilot study to treat stress urinary incontinence.	18204978
Sui Chinese, Urinary Stress Incontinence	Stem Cell Exhaustion	We hereby report a 1-year follow-up on eight women in the first North America trial in which stress urinary incontinence (SUI) was treated with muscle-derived stem cell injections.	18204978
Primary Biliary Cholangitis, Autoimmune Chronic Hepatitis	Stem Cell Exhaustion	We have recently reported quantitative and qualitative differences of the bone marrow (BM) hematopoietic progenitor cells in autoimmune hepatitis type-1 (AIH-1) and primary biliary cirrhosis (PBC).	18205770
leukemia	Stem Cell Exhaustion	Despite intensive chemotherapy and two hematopoietic stem cell transplants, he died of the leukemia.	18206536
Malignant Childhood Neoplasm, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukemia (AML) is a malignant neoplasm of hematopoietic stem cells characterized by an abnormal proliferation of myeloid precursors, a reduced rate of apoptosis, and an arrest in cellular differentiation.	18206543
Failure	Stem Cell Exhaustion	We present a phase II study of fludarabine 5 x 30 mg/m(2), thiotepa 3 x 5 mg/kg as preparative regimen specifically for allogeneic second haematopoietic stem cell transplantation (HCT) after failure of previous HCT.	18209719
Cytomegalovirus Infections	Stem Cell Exhaustion	Validation of a DNAemia cutoff for preemptive therapy of cytomegalovirus infection in adult hematopoietic stem cell transplant recipients.	18209721
Communicable Diseases	Stem Cell Exhaustion	A randomized trial comparing a DNAemia cutoff of 10 000 copies per ml whole blood and first pp65 antigenemia positivity for initiation of preemptive therapy of human cytomegalovirus (HCMV) infection in adult hematopoietic stem cell transplant recipients was completed.	18209721
Inflammation	Stem Cell Exhaustion	Polymorphisms in cytokine genes can influence immune responses and inflammation and thereby affecting the outcome of hematopoietic stem-cell transplantation.	18209723
Inflammation, Ocular Surface Disease Index	Stem Cell Exhaustion	Abnormal keratocytes and stromal inflammation in chronic phase of severe ocular surface diseases with stem cell deficiency.	18211946
Schwartz-Jampel Syndrome, Burn injury, Stevens-Johnson Syndrome, Ocular Cicatricial Pemphigoid, Inflammation	Stem Cell Exhaustion	Stevens-Johnson syndrome (SJS), ocular cicatricial pemphigoid (OCP) and alkali burns are associated with chronic, severe inflammation of the ocular surface that occasionally lead to corneal stem cell deficiencies.	18211946
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Hematopoietic stem cell transplantation after reduced intensity conditioning in acute myelogenous leukemia patients older than 40 years.	18215778
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic graft-versus-host disease (cGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (HSCT) and a leading cause of non-relapse mortality (NRM).	18215781
Lymphoma, Follicular	Stem Cell Exhaustion	Reduced-intensity conditioning (RIC) regimens have been increasingly used for allogeneic hematopoietic stem cell transplantation (HSCT) in follicular lymphoma (FL).	18215784
Hematopoiesis	Stem Cell Exhaustion	Although this pathway plays an important role in the maintenance of haematopoietic stem cells as well as in oncogenesis, the significance of nuclear NPBC remains unclear in malignant haematopoiesis.	18217891
Retinal Degeneration, Retinal Diseases	Stem Cell Exhaustion	These observations suggest that both microglia and CSPGs constitute a barrier for stem cell migration following transplantation into experimental models of retinal degeneration and that control of matrix deposition and the innate microglial response to neural retina degeneration may need to be addressed when translating cell-based therapies to treat human retinal disease.	18218817
Tachycardia, Ventricular, Peripheral Stem Cell Transplantation, Heart Failure, Diastolic, Senile cardiac amyloidosis	Stem Cell Exhaustion	Attenuation of diastolic heart failure and life-threatening ventricular tachyarrhythmia after peripheral blood stem cell transplantation combined with cardioverter-defibrillator implantation in myeloma-associated cardiac amyloidosis.	18219175
Failure	Stem Cell Exhaustion	The sepsis-related Organ Failure Assessment (SOFA) score is predictive for survival of patients admitted to the intensive care unit following allogeneic blood stem cell transplantation.	18219487
Impaired T cell function	Stem Cell Exhaustion	The discrepancy with previous findings may be related to the high prevalence of cardiovascular risk factors which causes endothelial progenitor cell dysfunction.	18221334
Engraftment syndrome	Stem Cell Exhaustion	Peripheral blood stem cell transplant for POEMS syndrome is associated with high rates of engraftment syndrome.	18221391
Degenerative polyarthritis	Stem Cell Exhaustion	Differential proteome of bone marrow mesenchymal stem cells from osteoarthritis patients.	18222713
Treatment related secondary malignancy, Chronic granulomatous disease	Stem Cell Exhaustion	Allogeneic hematopoietic stem-cell transplantation (HSCT) for chronic granulomatous disease (CGD) with a reduced-intensity conditioning regimen can be expected to lead to less therapy-related mortality and late-onset impairment, whereas it has also been reported to increase the risk of unsustained mixed donor chimerism and late rejection after transplantation.	18224420
Cessation of life, Neutropenia, Mycoses	Stem Cell Exhaustion	Invasive fungal infection is one of the major causes of death in neutropenic patients undergoing allogeneic stem cell transplantation (SCT).	18224421
Malignant neoplasm of brain	Stem Cell Exhaustion	High-dose chemotherapy with autologous stem cell rescue for children with recurrent malignant brain tumors.	18224664
Malignant Neoplasms	Stem Cell Exhaustion	High-dose chemotherapy (HDCT) with autologous stem cell rescue (ASCR) has been reported to be effective in treating children with recurrent central nervous system (CNS) malignancies.	18224664
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The group included 20 de novo and 26 relapsed AML patients, among whom, 12 relapsed after allogeneic hematopoietic stem cell transplantation (HSCT) and 4 after autologous HSCT.	18225565
ACTH-Secreting Pituitary Adenoma	Stem Cell Exhaustion	ACTH and alpha-subunit are co-expressed in rare human pituitary corticotroph cell adenomas proposed to originate from ACTH-committed early pituitary progenitor cells.	18228160
Adenoma	Stem Cell Exhaustion	As ACTH and alpha-subunit are the earliest hormones to appear during development, we speculate that these particular adenomas are derived from committed ACTH progenitor cells.	18228160
Acute Erythroblastic Leukemia	Stem Cell Exhaustion	This case belongs to the group of 'early' erythroblastic leukaemias where a subset of progenitor cells present with erythroid-megakaryocyte bipotentiality or are blocked at an early BFU-E (burst-forming unit erythrocyte)-like stage of erythroid differentiation (11, 12, 13).	18229464
HFE wt Allele	Stem Cell Exhaustion	From this cluster, we identified Insm1 and Nhlh1/NSCL1 as novel HH targets induced by Shh treatment in cultured cerebellar granule cell progenitors.	18231642
Malignant neoplasm of urinary bladder	Stem Cell Exhaustion	This study indicated the existence of few Oct4 positive cells in bladder cancer, which may be the bladder cancer stem cells.	18231740
Malignant neoplasm of urinary bladder	Stem Cell Exhaustion	This study may provide the foundation for isolation and identification of bladder cancer stem cells.	18231740
Multiple Myeloma	Stem Cell Exhaustion	Flow cytometric minimal residual disease monitoring in patients with multiple myeloma undergoing autologous stem cell transplantation: a retrospective study.	18231918
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We retrospectively reviewed the flow cytometry (FCM) data from bone marrow aspirates of multiple myeloma (MM) patients before and after autologous stem cell transplantation (ASCT).	18231918
Choroidal retinal neovascularization	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) have been shown to contribute to experimentally induced choroidal neovascularisation (CNV) in animal models.	18234239
Coronary Arteriosclerosis	Stem Cell Exhaustion	The effect of endothelial progenitor cells on the development of collateral formation in patients with coronary artery disease.	18239320
Virus Diseases	Stem Cell Exhaustion	Human cytomegalovirus-specific CD4+ and CD8+ T-cell reconstitution in adult allogeneic hematopoietic stem cell transplant recipients and immune control of viral infection.	18245650
Neoplasms	Stem Cell Exhaustion	A comparison between low intensity and reduced intensity conditioning in allogeneic hematopoietic stem cell transplantation for solid tumors.	18245651
Neoplasms	Stem Cell Exhaustion	Following different types of conditioning, allogeneic hematopoietic stem cell transplantation produces a graft-versus-tumor effect in patients with solid tumors.	18245651
Renal Cell Carcinoma, Primary Malignant Liver Neoplasm, Colorectal Carcinoma, Neoplasms	Stem Cell Exhaustion	Allogeneic stem cell transplantation was performed in 48 patients with metastatic renal cell cancer (n=17), colo-rectal cancer (n=15), non-metastatic advanced primary liver cancer after orthotopic liver transplantation (n=11), and other solid tumors (n=5).	18245651
Neoplasms	Stem Cell Exhaustion	Patients with limited tumor load are indicated for allogeneic stem cell transplantation and reduced intensity conditioning may be favorable compared to low intensity conditioning.	18245651
Acute lymphocytic leukemia	Stem Cell Exhaustion	Reduced intensity conditioning allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation.	18245655
Acute lymphocytic leukemia	Stem Cell Exhaustion	This retrospective study reported the outcome of 97 adult acute lymphoblastic leukemia patients who received a reduced-intensity conditioning allogeneic stem cell transplantation.	18245655
Graft-vs-Host Disease, Acute lymphocytic leukemia	Stem Cell Exhaustion	In multivariate analysis, disease status (CR1 vs. advanced; p=0.001) and chronic graft-vs-host disease (p=0.01) were associated with an improved overall-survival, suggesting that reduced-intensity conditioning allogeneic stem cell transplantation is feasible in patients with high risk lymphoblastic leukemia in remission at transplantation.	18245655
Nasal Type Extranodal NK/T-Cell Lymphoma	Stem Cell Exhaustion	[Treatment outcome and prognosis of autologous hematopoietic stem cell transplantation combined with high dose radiotherapy/chemotherapy in 22 patients with nasal NK/T cell lymphoma].	18246818
Nasal Type Extranodal NK/T-Cell Lymphoma	Stem Cell Exhaustion	To analyze the outcome and prognosis of autologous hematopoietic stem cell transplantation (AHSCT) combined with high dose radiotherapy/chemotherapy in 22 patients with nasal NK/T cell lymphoma.	18246818
Multiple Myeloma	Stem Cell Exhaustion	DCEP chemotherapy followed by a single, fixed dose of pegylated filgrastim allows adequate stem cell mobilization in multiple myeloma patients.	18248573
Chemotherapy-Induced Febrile Neutropenia	Stem Cell Exhaustion	Pegylated filgrastim (PEG-f), a long-lasting granulocyte-colony-stimulating factor, has been used in different hematologic conditions to shorten chemotherapy-induced neutropenia and to mobilize peripheral blood stem cells.	18248573
Multiple Myeloma	Stem Cell Exhaustion	These results, compared with those previously reported for the DCEP-filgrastim combination, suggest that DCEP chemotherapy followed by PEG-f is a promising combination to mobilize peripheral blood stem cells in myeloma patients.	18248573
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	However, among the subpopulation of CD34(+)CD38(-) AML cells (candidate "leukemic stem cells"), elevated expression of MDR1 and/or BCRP1, two ABC transporters associated with drug resistance, was found in 8 of 10 NR patients as compared to 0 of 7 CR patients.	18249061
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Expression of MDR1 and BCRP1 in leukemic stem cells correlates with chemotherapy response both at the cellular level and in AML patients.	18249061
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	AML patients with 11q23 aged <60 years in the first CR who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) showed a more favorable outcome than those treated without allo-HSCT, although the differences were not statistically significant (P = 0.322 for DFS, P = 0.138 for OS).	18253706
Gastrointestinal mucositis	Stem Cell Exhaustion	Alimentary mucositis is a life-threatening side effect in patients receiving conditioning therapy for stem cell transplantation.	18256857
Peripheral Blood Stem Cells, Intestines	Stem Cell Exhaustion	The aim of our study was to investigate small intestinal lesions using video-capsule endoscopy in patients undergoing peripheral blood stem cells transplantation.	18256857
Large Intestinal Mucositis, Ulcer	Stem Cell Exhaustion	Our data reveal for the first time that small intestinal mucositis in patients undergoing conditioning therapy for peripheral blood stem cells transplantation presents as small intestinal ulcerations and that palifermin treatment prevents these lesions.	18256857
Multiple Myeloma	Stem Cell Exhaustion	Symptom burden after autologous stem cell transplantation for multiple myeloma.	18260091
Graft-vs-Host Disease	Stem Cell Exhaustion	Postmortem examination of the kidney in allogeneic hematopoietic stem cell transplantation recipients: possible involvement of graft-versus-host disease.	18264743
Graft-vs-Host Disease, Hematologic Neoplasms, Injury of kidney	Stem Cell Exhaustion	To investigate the association between graft-versus-host disease (GVHD) and renal injury after allogeneic stem cell transplantation (allo-SCT), we compared autopsy findings of 26 consecutive allo-SCT recipients with two control groups: patients with hematologic malignancies who received cytotoxic chemotherapy alone (Control 1, n = 21) and those with non-hematologic diseases (Control 2, n = 12).	18264743
Carcinoma, Spindle-Cell	Stem Cell Exhaustion	Molecular genetic findings in two cases of sarcomatoid carcinoma of the ureter: evidence for evolution from a common pluripotent progenitor cell?	18266004
Ewings sarcoma	Stem Cell Exhaustion	Allogeneic stem cell transplantation in a patient with relapsed Ewing sarcoma.	18266223
Ewings sarcoma, Neoplasms	Stem Cell Exhaustion	Ewing sarcoma (ES) can express tumor antigens which can be recognized by T cells, making allogeneic stem cell transplant (SCT) a potential option for those patients with refractory disease.	18266223
Renal glomerular disease	Stem Cell Exhaustion	Transplantation of human fetal mesenchymal stem cells improves glomerulopathy in a collagen type I alpha 2-deficient mouse.	18266309
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	A phase 2 pilot study of pegfilgrastim and filgrastim for mobilizing peripheral blood progenitor cells in patients with non-Hodgkin's lymphoma receiving chemotherapy.	18268285
Stomatitis, Multiple Myeloma, Lymphoma, Non-Hodgkin, Gastrointestinal mucositis, Lymphoma, Non-Hodgkin, Familial, Toxic effect, Morular Metaplasia of the Endometrium	Stem Cell Exhaustion	The Prospective Oral Mucositis Audit assessed the incidence, duration, and determinants of severe oral mucositis (OM; WHO oral toxicity scale grades 3 to 4) in patients with multiple myeloma (MM) or non-Hodgkin's lymphoma (NHL) receiving high-dose conditioning chemotherapy before autologous stem-cell transplantation.	18268357
Childhood Breast Carcinoma	Stem Cell Exhaustion	Independent prognostic value of the basal-like phenotype of breast cancer and associations with EGFR and candidate stem cell marker BMI-1.	18269588
Basal-Like Breast Carcinoma	Stem Cell Exhaustion	To study the relationship between basal-like breast cancers, epidermal growth factor receptor (EGFR) and candidate stem cell markers (BMI-1, EZH2, Oct-4) in a population-based setting.	18269588
Neoplasms	Stem Cell Exhaustion	In addition, immunohistochemical staining with antibodies to melanocyte-stimulating cytokines, including endothelin-1, stem cell factor, and nerve growth factor, was done on these tumours.	18269598
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	High-dose chemotherapy and autologous hematopoietic progenitor cell transplantation for non-Hodgkin's lymphoma in patients >65 years of age.	18272911
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	We present a retrospective analysis of 99 consecutive patients with relapsed non-Hodgkin's lymphomas who were older than 65 years at the time of high-dose chemotherapy and autologous progenitor cell transplantation.	18272911
Graft-vs-Host Disease	Stem Cell Exhaustion	Several reports, including previous reports from our laboratory, suggest that OX40-mediated signaling plays an important role in the development of graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (Allo HSCT).	18275893
Rheumatoid Arthritis	Stem Cell Exhaustion	BMP-activated cells belong to distinct stromal compartments in RA synovium and some of them express markers associated with the mesenchymal progenitor cell lineage.	18276742
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Telomere gap between granulocytes and lymphocytes is a determinant for hematopoetic progenitor cell impairment in patients with previous myocardial infarction.	18276909
Ischemic cardiomyopathy	Stem Cell Exhaustion	We have previously demonstrated that ischemic cardiomyopathy is associated with selective impairment of progenitor cell function in the bone marrow and in the peripheral blood, which may contribute to an unfavorable left ventricular remodeling process.	18276909
Kidney Diseases	Stem Cell Exhaustion	[Salt-wasting nephropathy induced by foscarnet treatment for HHV-6 encephalitis in a hematopoietic stem cell transplant].	18277595
Neoplasms	Stem Cell Exhaustion	A large number of proteins expressed in normal oral epithelium and HNSCC, including cytokeratins, intermediate filaments, differentiation markers, and proteins involved in stem cell maintenance, signal transduction, migration, cell cycle regulation, growth and angiogenesis, matrix degradation, and proteins with tumor suppressive and oncogenic potential, were readily detected.	18281532
Diarrhea, Multiple Myeloma, Communicable Diseases	Stem Cell Exhaustion	We present a case of diarrhea secondary to biopsy-proven adenovirus (ADV) infection after autologous peripheral hematopoietic stem cell transplant for multiple myeloma.	18282236
Infection of digestive system	Stem Cell Exhaustion	To our knowledge, this is the first report in an adult hematopoietic stem cell recipient of the use of low-dose cidofovir to treat proven ADV gastrointestinal infection.	18282236
Rheumatism	Stem Cell Exhaustion	[Treatment of refractory rheumatism among preschool children with autologous peripheral blood hematopoietic stem cell transplantation].	18282409
Rheumatism	Stem Cell Exhaustion	To investigate the feasibility and safety of autologous peripheral blood hematopoietic stem cell transplantation (auto-PBHSCT) and its therapeutic effect on refractory rheumatism among preschool children.	18282409
Medulloblastoma	Stem Cell Exhaustion	To determine the survival of infants and young children with non-metastatic medulloblastoma using intensive myeloablative chemotherapy and autologous hematopoietic progenitor cell rescue (AuHCR).	18293379
Specialty Type - cancer, Aneuploidy	Stem Cell Exhaustion	Defining the steps that lead to cancer: replicative telomere erosion, aneuploidy and an epigenetic maturation arrest of tissue stem cells.	18294777
Specialty Type - cancer	Stem Cell Exhaustion	Consequently, the phenotype of cancer tissue is largely determined by the epigenetic maturation arrest of tissue stem cells, which in addition enables a fraction of cancer cells to proliferate, invade and metastasize, as normal adult stem cells do.	18294777
Leukemic Phase of Non-Hodgkins Lymphoma	Stem Cell Exhaustion	A total of 1,032 patients underwent TBI in one or two fractions before autologous or allogeneic hematologic stem cell transplantation for acute leukemia and non-Hodgkin's lymphoma.	18294781
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Successful autologous stem cell collection in patients with chronic myeloid leukemia in complete cytogenetic response, with quantitative measurement of BCR-ABL expression in blood, marrow, and apheresis products.	18297531
Leukemia, Myelocytic, Acute, Acute leukemia	Stem Cell Exhaustion	Radioimmunotherapeutic strategies targeting CD66 antigens should consider the heterogeneous expression pattern of CD66 molecules in acute leukemias especially in AML where expression is correlated with mature granulomonocytic cells but not with CD34 and CD117 positive progenitor cells.	18299959
AIDS-Related Hodgkin Lymphoma	Stem Cell Exhaustion	A long-term durable remission with high-dose therapy and autologous stem cell transplant for stage IVB HIV-associated Hodgkins disease.	18301069
AIDS-Related Hodgkin Lymphoma	Stem Cell Exhaustion	A 44-year-old man with relapsed HIV-associated stage IV nodular sclerosing Hodgkin's disease underwent high-dose therapy with autologous stem cell transplantation.	18301069
Hodgkin Disease	Stem Cell Exhaustion	Autologous stem cell transplantation is safe in HIV patients and can achieve long-term durable remissions in Hodgkin's disease.	18301069
Acute Promyelocytic Leukemia	Stem Cell Exhaustion	Hematopoietic stem cell transplantation for acute promyelocytic leukemia in second or third complete remission: a retrospective analysis in the Nagoya Blood and Marrow Transplantation Group.	18301963
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Intensive chemotherapy (high-dose CHOP/ESHAP regimen) followed by autologous stem-cell transplantation in previously untreated patients with peripheral T-cell lymphoma.	18303032
Peripheral T-Cell Lymphoma, Toxic effect	Stem Cell Exhaustion	To analyze toxicity, response and outcome of a phase II trial with intensive chemotherapy plus autologous stem-cell transplantation (ASCT) for young patients with peripheral T-cell lymphoma (PTCL).	18303032
Dilated Cardiomyopathy Pathway	Stem Cell Exhaustion	Decreased small arterial compliance with increased serum vascular endothelial growth factor-A and circulating endothelial progenitor cell in dilated cardiomyopathy.	18304463
Stem Cell Factor, Cytogenetic Complete Response	Stem Cell Exhaustion	Most importantly, decreased CFU-F and the adhesive rate of BMSC were correlated significantly with decreased interleukins and stem-cell factor (IL-6, SCF and FLT-3L) expressions in the CRC patients after chemotherapy.	18304729
Colorectal Carcinoma	Stem Cell Exhaustion	Effects of adjuvant chemotherapy on bone marrow mesenchymal stem cells of colorectal cancer patients.	18304729
Hematologic Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	The significant hurdles we must overcome include: the apparent infrequency of an exogenous cause that can be avoided, the exponential increase in incidence rates with age and the dramatic negative effect of aging on the results of treatment, the challenge of one trillion or more disseminated cancer cells among which are a smaller population of cancer stem cells, the profound genetic diversity of the hematological malignancies (apparently hundreds of unique genetic primary lesions), the redundant growth and survival pathways defining the cancer phenotype, the decreasing market for pharmaceutical companies as therapy becomes more specific (fewer target patients) and drug development costs become more expensive, and the significant negative long-term effects of current therapy on both children and adults.	18305057
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Stem cell therapy is a promising treatment after myocardial infarction (MI).	18305959
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Accumulation of fibronectin in the heart after myocardial infarction: a putative stimulator of adhesion and proliferation of adipose-derived stem cells.	18305959
Neuralgia	Stem Cell Exhaustion	CIPS in patients with hematopoietic stem cell transplants treated with FK may have a mechanism by which neuropathic pain may develop that is different from that in patients with other organ transplants.	18306017
Aplastic Anemia	Stem Cell Exhaustion	Outcome of unrelated donor stem cell transplantation for children with severe aplastic anemia.	18307564
Aplastic Anemia	Stem Cell Exhaustion	For children with severe aplastic anemia (SAA) who fail immunosuppressive therapy and lack a human leucocyte antigen (HLA)-matched sibling donor, unrelated donors provide a source of hematopoietic stem cells.	18307564
Neoplasms	Stem Cell Exhaustion	In responders, surgical excision of the primary tumour was attempted, followed by myeloablation (with 200 mg/m2 of melphalan) and haemopoietic stem-cell rescue.	18308250
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Although chronic lymphocytic leukemia (CLL) has remained incurable with standard treatments, newer therapeutic approaches, such as chemoimmunotherapy or stem cell transplantation, bear the potential for prolonged survival.	18309034
Diabetes	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) have been shown to be involved in vascular regeneration and angiogenesis in experimental diabetes.	18309377
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Because insulin therapy mobilizes circulating progenitor cells, we studied the effects of insulin on outgrowth of EPCs from peripheral blood mononuclear cells of healthy volunteers and patients with type 2 diabetes.	18309377
LMNA wt Allele	Stem Cell Exhaustion	Our results support a model in which accelerated ageing in HGPS patients, and possibly also physiological ageing, is the result of adult stem cell dysfunction and progressive deterioration of tissue functions.	18311132
Type II Mucolipidosis	Stem Cell Exhaustion	Platelet count is a sensitive predictor of autologous peripheral blood progenitor cell collection yield in previously treated plasma cell disease patients.	18315528
Liver Cirrhosis	Stem Cell Exhaustion	Stem cell mobilization and collection in patients with liver cirrhosis.	18315586
Injury of liver	Stem Cell Exhaustion	Bone marrow-derived stem cells (BMSC) and granulocyte colony-stimulating factor (G-CSF) have been proved to contribute to tissue regeneration after liver injury.	18315586
Insulin-dependent diabetes mellitus secretory diarrhea syndrome, X-linked infantile spasms, Abnormality of the intestine	Stem Cell Exhaustion	Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome is often initially treated with immunosuppressive drugs, but only allogeneic hematopoietic stem cell transplantation has offered the possibility of cure.	18316354
Lymphoma, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Psychosocial, health and demographic characteristics of quality of life among patients with acute myeloid leukemia and malignant lymphoma who underwent autologous hematopoietic stem cell transplantation.	18317610
Atypical Teratoid Rhabdoid Tumor	Stem Cell Exhaustion	Successful outcome with tandem myeloablative chemotherapy and autologous peripheral blood stem cell transplants in a patient with atypical teratoid/rhabdoid tumor of the central nervous system.	18317689
Neoplasms	Stem Cell Exhaustion	We herein report the case of a 4-month-old boy with ATRT with partial resection of his tumor who achieved complete remission using tandem high-dose therapy followed by autologous peripheral blood stem cell re-infusions despite having biopsy proven disease at the time of starting the tandem regimens.	18317689
Disease, Multiple Myeloma	Stem Cell Exhaustion	Outcome after autologous stem cell transplantation for multiple myeloma in patients with preceding plasma cell disorders.	18318761
Lymphoma, Follicular	Stem Cell Exhaustion	The role of haematopoietic stem cell transplantation (HSCT) in relapsed follicular lymphoma remains controversial.	18318762
Cytomegalovirus Infections	Stem Cell Exhaustion	Clinical features of late cytomegalovirus infection after hematopoietic stem cell transplantation.	18320138
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Our period analysis reveals major improvement on the population level in long-term prognosis of younger patients with acute myeloblastic leukemia, most likely explained by multiple incremental improvements in care including better and more specific diagnosis, improvements in and extension of the use of stem cell transplantation and high dose therapy, and improved supportive care.	18322250
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	The clinical data of 73 patients with PTCL were reviewed.The median pre-treatment disease course was 3 months.Fifty-five patients were males, and 18 were females, with the median age of 42 years.Five patients received the combined chemo-radio therapy, 65 received chemotherapy alone, and the other 3 patients were treated with auto hematopoietic stem cell transplantation (HSCT).	18326910
Conical primary incisor, Tooth structure	Stem Cell Exhaustion	Dental pulp stem cells (DPSCs) were primarily derived from the pulp tissues of primary incisors and permanent third molar teeth, whereas no report to our knowledge has yet been documented on deriving DPSCs from the other tooth types.	18331285
Tooth structure	Stem Cell Exhaustion	The aim of this study is to present a novel approach of harvesting stem cells from a supernumerary tooth (a mesiodens).	18331285
Klinefelter Syndrome, Wiskott-Aldrich Syndrome	Stem Cell Exhaustion	Hematopoietic stem cell transplantation from a donor with Klinefelter syndrome for Wiskott-Aldrich syndrome.	18331539
Toxic effect	Stem Cell Exhaustion	Involved-field radiotherapy before high-dose therapy and autologous stem-cell rescue in diffuse large-cell lymphoma: long-term disease control and toxicity.	18332466
Toxic effect, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	To analyze outcome, prognostic factors, and toxicities in patients with diffuse large-cell lymphoma (DLCL) who received involved-field radiotherapy (IFRT) before high-dose chemotherapy with autologous stem-cell rescue (ASCR).	18332466
Sarcoma - category (morphologic abnormality)	Stem Cell Exhaustion	Large institutional experience with dose-intensive chemotherapy and stem cell support in the management of sarcoma patients.	18334832
Malignant Neoplasms	Stem Cell Exhaustion	Recently, genes occupied by Polycomb proteins in embryonic stem cells were shown to be vulnerable to aberrant DNA hypermethylation in cancers.	18335237
Specialty Type - cancer	Stem Cell Exhaustion	Cancer arises from surviving cells, or even stem cells, that have down-regulated many pathways, including apoptosis, that regulate genomic stability in a multi-step process.	18336867
Acute myelomonocytic leukemia, Malignant Neoplasms	Stem Cell Exhaustion	Adiponectin plays a protective role in several malignancies, including myeloblastic leukemia, whereas leptin may increase the proliferation of progenitor cells and may stimulate leukemic cell growth in vitro.	18337619
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 15-year-old girl with acute myeloid leukaemia had taken oral prednisolone, 60 mg/day, for graft versus host disease after haematopoietic stem cell transplantation.	18339037
Tissue injury	Stem Cell Exhaustion	It is suggested that fetal cells are present at sites of tissue injury and may be stem cells, either recruited from marrow or having proliferated locally.	18339261
Myocardial necrosis	Stem Cell Exhaustion	Radiofrequency ablation generates a localized myocardial necrosis that might result in a release of inflammatory mediators enhancing progenitor cell mobilization and improving tissue repair.	18339614
Myocardial necrosis	Stem Cell Exhaustion	Thus, isolated myocardial necrosis may not be sufficient to account for progenitor cell mobilization.	18339614
Myocardial necrosis, Atrial Fibrillation, Atrial Fibrillation by ECG Finding	Stem Cell Exhaustion	Aim of this study was to investigate the number of circulating progenitor cells, systemic inflammatory mediators, and myocardial necrosis in patients with paroxysmal atrial fibrillation (AF) undergoing pulmonary vein (PV) isolation by radiofrequency (RF) ablation.	18339614
Myocardial necrosis	Stem Cell Exhaustion	Although PV isolation by RF ablation in patients with paroxysmal AF induces a systemic inflammatory response associated with myocardial necrosis, no alterations in circulating progenitor cells were observed.	18339614
Neoplasms, Carcinogenesis	Stem Cell Exhaustion	The high prevalence of estrogen-induced epigenetic changes in primary tumors and the surrounding histologically normal tissues provides the first empirical link between estrogen injury of breast stem/progenitor cells and carcinogenesis.	18339859
Pneumonia	Stem Cell Exhaustion	[Granulocyte transfusion for the treatment of prolonged pneumonia in a patient with MDS-RAEB-2 at allogeneic hematopoietic stem cell transplantation].	18341038
Mycobacterium Infections	Stem Cell Exhaustion	[Cutaneous non-tuberculous mycobacterial infection following cord blood stem cell transplantation].	18341040
Nontuberculous Mycobacteria, Familial Hemophagocytic Lymphocytosis, Lymphohistiocytosis, Hemophagocytic, Communicable Diseases	Stem Cell Exhaustion	We describe a 4-year-old-girl with familial hemophagocytic lymphohistiocytosis (FHL) who developed disseminated cutaneous nontuberculous mycobacterial (NTM) infection after unrelated cord blood stem cell transplantation (uCBSCT).	18341040
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Following a sex-mismatched hematopoietic stem cell transplantation (HSCT), we monitored the clinical course of a 61-year old male AML M6 patient with trisomy 8 using PCR-STR with a TH01 locus on 11p15 and fluorescence in situ hybridization (FISH) analysis specific for alpha satellite DNA on chromosome 8.	18341042
Chronic Kidney Disease, CTCAE	Stem Cell Exhaustion	Chronic kidney disease after nonmyeloablative stem cell transplantation in adults.	18342782
Chronic Kidney Diseases, Chronic Kidney Disease, CTCAE	Stem Cell Exhaustion	Chronic kidney disease (CKD) after myeloablative stem cell transplantation (SCT) is a well-established problem.	18342782
Lymphoma	Stem Cell Exhaustion	Allogeneic stem cell transplantation (SCT) with reduced-intensity conditioning (RIC) has the potential to lead to long-term remissions for patients with lymphoma.	18342784
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic graft-versus-host disease (cGVHD) is a common late complication of allogeneic stem cell transplantation (allo-SCT).	18342785
Chronic graft-versus-host disease	Stem Cell Exhaustion	Circulating endothelial progenitor cells decreased in patients with sclerodermatous chronic graft-versus-host disease.	18342785
Stable chronic Graft vs Host Disease, Skin lesion, Systemic Scleroderma	Stem Cell Exhaustion	Some cGVHD patients develop skin lesions, and the skin lesions in sclerodermatous cGVHD (s-cGVHD) patients resemble those in progressive systemic sclerosis (PSS), which is characterized by impaired production of circulating endothelial progenitor cells (EPCs).	18342785
Hematologic Neoplasms	Stem Cell Exhaustion	Haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for treatment of hematological malignancies in children.	18342790
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Close association of aberrant CD7 expression and FLT3/ITD mutation in the myeloblasts of FLT3/ITD+ AML suggests that FLT3/ITD- mediated leukemic transformation occurs in the more early stage of myeloid progenitor cells.	18343790
Amyloidosis	Stem Cell Exhaustion	High-dose melphalan followed by autologous stem cell support is a standard therapy for primary systemic AL amyloidosis, but in high-risk cases for this treatment, such as elderly patients and those with multiple organ involvement, VAD might be a therapeutic option.	18344643
Amyloidosis	Stem Cell Exhaustion	Further prospective studies are needed in patients with IgM-related amyloidosis, with special emphasis on treatment options: hematopoietic stem cell transplantation and purine analogs could represent the most effective therapies.	18344807
NCI CTEP SDC Oligodendroglial Tumors Sub-Category Terminology	Stem Cell Exhaustion	Stem cell protein BMI-1 is an independent marker for poor prognosis in oligodendroglial tumours.	18346113
Hemopoietic stem cell transplant	Stem Cell Exhaustion	Predictive factors for outcomes after reduced intensity conditioning hematopoietic stem cell transplantation for hematological malignancies: a 10-year retrospective analysis from the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire.	18346838
Hematologic Neoplasms	Stem Cell Exhaustion	This retrospective study analyzed the impact of demographic and transplantation variables on outcomes of 1108 patients who have undergone allogeneic hematopoietic stem cell transplantation after reduced intensity conditioning (RIC HSCT) for hematological malignancies and were reported to the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire registry between November 1994 and December 2004.	18346838
Bronchiolitis Obliterans, Allogeneic Hematopoietic Stem Cell Transplantation, Idiopathic pneumonia syndrome	Stem Cell Exhaustion	Prognostic value of serum surfactant protein D level prior to transplant for the development of bronchiolitis obliterans syndrome and idiopathic pneumonia syndrome following allogeneic hematopoietic stem cell transplantation.	18347569
Bronchiolitis Obliterans, Idiopathic pneumonia syndrome, Bosnian language	Stem Cell Exhaustion	Bronchiolitis obliterans syndrome (BOS) and idiopathic pneumonia syndrome (IPS) cause high mortality and impaired survival after allogeneic hematopoietic stem-cell transplantation (allo-HSCT).	18347569
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Improved survival has been observed in poor-risk diffuse large B-cell lymphoma (DLBCL) patients treated with high-dose therapy (HDT) followed by autologous stem cell transplantation (ASCT) in first complete remission.	18348654
Specialty Type - cancer, Neoplasms, Pancreatic carcinoma	Stem Cell Exhaustion	Although CD133 has been shown to be a marker for cancer stem cells in various tumours, its expression in pancreatic cancer has not yet been clinically reported.	18349830
Lymphoma	Stem Cell Exhaustion	IVE (ifosfamide, epirubicin and etoposide) is a more effective stem cell mobilisation regimen than ICE (ifosphamide, carboplatin and etoposide) in the context of salvage therapy for lymphoma.	18353164
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	This analysis of two similar groups of patients treated within a single-centre appears to demonstrate that the IVE regimen is a more effective stem cell mobilisation regimen than ICE in the context of salvage therapy for Hodgkin and non-Hodgkin lymphoma, allowing more patients to achieve the target CD34+ cell collection and proceed to high-dose therapy and autologous stem cell transplantation.	18353164
Lymphoma	Stem Cell Exhaustion	Two commonly used chemotherapy regimens for lymphoma salvage therapy were compared: ICE (ifosphamide, carboplatin and etoposide) +/- rituximab and IVE (ifosfamide, epirubicin and etoposide) +/- rituximab, for their efficacy in mobilising peripheral blood stem cells for autologous transplantation.	18353164
Cardiovascular calcification, Uremia	Stem Cell Exhaustion	As circulating endothelial progenitor cells (EPCs) harbour vascular regenerative potential and are altered in uraemia, we examined clinical and biochemical factors influencing EPC levels as well as the relation between EPC numbers and function and uraemic cardiovascular calcifications.	18353889
Migraine Disorders	Stem Cell Exhaustion	Circulating endothelial progenitor cell (EPC) numbers and functions are reduced in migraine patients, suggesting that EPCs can be an underlying link between migraine and cardiovascular risk.	18354079
Migraine Disorders	Stem Cell Exhaustion	Decreased number and function of endothelial progenitor cells in patients with migraine.	18354079
Hodgkin Disease	Stem Cell Exhaustion	Long-term outcome of autologous stem-cell transplantation in relapsed or refractory Hodgkin's lymphoma.	18356139
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	The purpose of this study was to assess prognostic factors and outcome of patients with relapsed/refractory Hodgkin's lymphoma (HL) who received high-dose chemotherapy and autologous stem-cell transplant (ASCT).	18356139
Endothelial dysfunction, Acute Cerebrovascular Accidents	Stem Cell Exhaustion	Circulating endothelial progenitor cells as a new marker of endothelial dysfunction or repair in acute stroke.	18356550
Endothelial dysfunction	Stem Cell Exhaustion	Understanding on distinct subsets of endothelial progenitor cells may provide insights of endothelial dysfunction or repair in the acute ischemic event.	18356550
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	The clinical data of 148 patients of NHL with BMI, 108 undergoing CHOP regimen, 51 undergoing dose-intensive CHOP regimens, 13 undergoing CHOP regimen + rituximab, and 27 undergoing hemopoietic stem cell transplantation (HSCT) after CHOP protocol with remission.	18361837
Graft-vs-Host Disease	Stem Cell Exhaustion	Targeting mycophenolate mofetil for graft-versus-host disease prophylaxis after allogeneic blood stem cell transplantation.	18362900
Specimen Source Codes - Fistula	Stem Cell Exhaustion	The fistula was treated by bronchoscopic injection of autologous adipose-derived stem cells (ASC) suspended in fibrin glue.	18364447
Graft-vs-Host Disease	Stem Cell Exhaustion	The relationship between herpesvirus reactivation and graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (allo-SCT) is unclear.	18367292
Neoplasms	Stem Cell Exhaustion	Our observations indicate that tumours build vessels by cooption of pre-existing vasculature and de novo recruitment of endothelial progenitor cells.	18368627
Neoplasms	Stem Cell Exhaustion	This observation indicates that the tumour microenvironment determines biological and functional attributes of endothelial progenitor cells.	18368627
Postmenopausal state, Premature Menopause	Stem Cell Exhaustion	The human OSE stem cells preserve the character of embryonic stem cells, and they may produce distinct cell types, including new eggs in vitro, particularly when derived from patients with premature ovarian failure or aging and postmenopausal ovaries.	18370063
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Bortezomib, doxorubicin and dexamethasone (PAD) was evaluated as induction before stem cell transplantation in newly diagnosed multiple myeloma (MM) patients, using bortezomib 1.3 mg/m(2) (PAD1, N = 21) or 1.0 mg/m(2) (PAD2, N = 20).	18371113
Colon Carcinoma, Malignant tumor of colon	Stem Cell Exhaustion	Here, we describe the identification and characterization of such cells from colon carcinomas using the stem cell marker CD133 that accounts around 2% of the cells in human colon cancer.	18371377
Cessation of life, Malignant tumor of colon, Neoplasms	Stem Cell Exhaustion	Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.	18371377
Leukemia, Myelomonocytic, Chronic	Stem Cell Exhaustion	The functional behavior of hematopoietic stem cell (HSC) and progenitors in chronic myelomonocytic leukemia (CMML) and on disease progression is little known.	18372040
Pseudomonas aeruginosa, Communicable Diseases	Stem Cell Exhaustion	[Infection treatment caused by multiple-drug-resistant Pseudomonas aeruginosa in a patient undergoing allogeneic hematopoietic stem cell transplantation].	18379184
Heart failure	Stem Cell Exhaustion	Stem cell therapy for heart failure is a rapidly progressing field.	18381874
Ischemic cardiomyopathy, Cardiomyopathies, Dilated Cardiomyopathy Pathway	Stem Cell Exhaustion	Forty-one patients with cardiomyopathy (mean age, 58.5 +/- 14.3 years) underwent stem cell injection; 21 had dilated cardiomyopathy and 20 had ischemic cardiomyopathy.	18381874
Rheumatoid Arthritis, Hematopoietic stem cells	Stem Cell Exhaustion	Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis.	18383391
Rheumatoid Arthritis	Stem Cell Exhaustion	In RA, circulating bone marrow-derived progenitor cells were diminished, and concentrations stagnated at levels typical of those in old control subjects.	18383391
Astrocytoma	Stem Cell Exhaustion	Numb expression in astrocytomas recapitulates that of progenitor cells during neurodevelopment, and suggests a role for Numb in astrocytoma oncogenesis.	18384513
Liver carcinoma, Adult-onset citrullinemia type 2	Stem Cell Exhaustion	In addition to the clinical data of the 14 patients reported previously, the findings in our patient suggest that the citrin deficiency might be one of the key disorders causing hepatocellular carcinoma especially at younger ages and can also play an important role in hepatocarcinogenesis of the hepatic progenitor cells, which have the bipotential to differentiate into both hepatocytes and cholangiocytes.	18385606
Autoimmune reaction, Hemopoietic stem cell transplant	Stem Cell Exhaustion	A 30-year-old male presented with severe, warm autoimmune hemolysis 17 months subsequent to a matched, unrelated peripheral hematopoietic stem cell transplant.	18387171
Venoocclusive disease	Stem Cell Exhaustion	Venoocclusive disease (VOD) is the most frequent cause of early nonrelapse mortality among patients receiving high-dose chemoradiotherapy and hematopoietic stem cell transplantation.	18388499
Venoocclusive disease	Stem Cell Exhaustion	The objective was to retrospectively study the largest series of patients that has received antithrombin III for the treatment of VOD following hematopoietic stem cell transplantation.	18388499
Venoocclusive disease	Stem Cell Exhaustion	A total of 48 patients were diagnosed with VOD post hematopoietic stem cell transplantation (median age, 39 years; range, 1-69 years); 38 of the 48 received a nonradiation-based conditioning regimen and 21 of 48 received a transplant from an unrelated donor.	18388499
Aplasia Cutis Congenita	Stem Cell Exhaustion	Surgical resection of the primary and metastatic lesions with chemotherapy followed by autologous peripheral blood stem-cell transplantation could be an effective treatment for advanced ACC.	18391707
leukemia	Stem Cell Exhaustion	HPC markers, K7, K19, prominin-1, receptor for stem cell factor c-kit, octamer-4 transcription factor, and leukemia inhibitory factor were upregulated (P < 0.05), while albumin was downregulated in CLC (P = 0.007) toward K19-negative HCCs.	18393293
Carcinoma	Stem Cell Exhaustion	Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin.	18393293
Cholangiolocellular Carcinoma, Cholangiocarcinoma	Stem Cell Exhaustion	Cholangiolocellular carcinoma (CLC), a subtype of cholangiocellular carcinoma (CC), is thought to originate from the ductules/canals of Hering, where hepatic progenitor cells (HPCs) are located.	18393293
Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by the expansion of a PIG-A mutated hematopoietic stem cell.	18396213
Juvenile Myelomonocytic Leukemia	Stem Cell Exhaustion	A conditioning regimen of busulfan, fludarabine, and melphalan for allogeneic stem cell transplantation in children with juvenile myelomonocytic leukemia.	18397212
Hemopoietic stem cell transplant	Stem Cell Exhaustion	All patients were conditioned with oral busulfan (560 mg/m(2)), fludarabine (120 mg/m(2)), and melphalan (180-210 mg/m(2)) prior to HSCT, and received stem cells from bone marrow in seven cases, and from cord blood in three cases.	18397212
Lymphoma	Stem Cell Exhaustion	Pre-transplant 18FDG-PET predicts outcome in lymphoma patients treated with high-dose sequential chemotherapy followed by autologous stem cell transplantation.	18398740
Degenerative polyarthritis	Stem Cell Exhaustion	Abnormal transforming growth factor-beta expression in mesenchymal stem cells from patients with osteoarthritis.	18398939
Degenerative polyarthritis	Stem Cell Exhaustion	To determine the expression of the genes that code for the isoforms of transforming growth factor-beta (TGF-beta) and TGF-beta receptors (TBR) in mesenchymal stem cells (MSC) from patients with osteoarthritis (OA).	18398939
Hematologic Neoplasms	Stem Cell Exhaustion	Transfusion-associated iron overload as a predictive factor for poor stem cell mobilization in patients with haematological malignancies.	18399843
Parkinson Disease	Stem Cell Exhaustion	Isolation and characterization of mesenchymal stem cells derived from bone marrow of patients with Parkinson's disease.	18401666
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease (GVHD) was reduced using home care compared with hospital care after allogeneic hematopoietic stem-cell transplantation (ASCT).	18408581
BCR gene	Stem Cell Exhaustion	A total of 100 adults with ALL in first CR received melphalan (110 mg/m(2)) with TBI followed by autologous marrow (n=35) or single-agent melphalan (200 mg/m(2)) followed by autologous blood stem cells (n=65).	18408773
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Absolute lymphocyte count (ALC) recovery after autologous stem cell transplantation for multiple myeloma (MM) has been reported to be an independent prognostic factor for clinical outcome.	18410454
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Stem cell transplantation in poor-risk chronic lymphocytic leukemia: assessment of post-transplant minimal residual disease using four- and six-color flow cytometry and allele-specific RQ-PCR.	18410542
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	A total of 178 bone marrow samples were taken for minimal residual disease (MRD) analysis after 34 stem cell transplantations for poor-risk chronic lymphocytic leukemia, and 86 of them were analyzed in parallel by flow cytometry and allele-specific oligonucleotide-PCR (ASO-PCR).	18410542
Conn Syndrome	Stem Cell Exhaustion	Primary aldosteronism (PA) and endothelial progenitor cell (EPC) bioavailability.	18410543
Acute GVH disease	Stem Cell Exhaustion	Preengraftment serum C-reactive protein (CRP) value may predict acute graft-versus-host disease and nonrelapse mortality after allogeneic hematopoietic stem cell transplantation.	18410893
GDC Comorbidity Terminology, Hematological Disease	Stem Cell Exhaustion	Although allogeneic hematopoietic stem cell transplantation is a potentially curative approach for advanced hematologic diseases, its application to elderly people is limited because of their comorbid physical conditions and lower chance of finding suitable related donors.	18410901
Lymphoma, Follicular	Stem Cell Exhaustion	Eight-year experience with allogeneic stem cell transplantation for relapsed follicular lymphoma after nonmyeloablative conditioning with fludarabine, cyclophosphamide, and rituximab.	18411419
Lymphoma, Follicular	Stem Cell Exhaustion	Nonmyeloablative stem cell transplantation in patients with follicular lymphoma has been designed to exploit the graft-versus-lymphoma immunity.	18411419
Primary intraocular non-Hodgkin malignant lymphoma	Stem Cell Exhaustion	Intensive chemotherapy followed by hematopoietic stem-cell rescue for refractory and recurrent primary CNS and intraocular lymphoma: Societe Francaise de Greffe de Moelle Osseuse-Therapie Cellulaire.	18413641
Primary central nervous system lymphoma, Primary intraocular non-Hodgkin malignant lymphoma	Stem Cell Exhaustion	We report the results of a prospective multicenter trial of intensive chemotherapy followed by autologous hematopoietic stem-cell rescue (IC + HCR) in immunocompetent adult patients with PCNSL or intraocular lymphoma (IOL) after failure of high-dose methotrexate-based treatment.	18413641
Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	We sought confirmation that this tumor is a basal-like breast cancer, expressing epidermal growth factor receptor (EGFR) and stem cell factor receptor (KIT).	18413808
Medulloblastoma	Stem Cell Exhaustion	Medulloblastoma demonstrating multipotent differentiation is rare, but the features observed in this case support the idea that medulloblastoma originates from multipotent stem cells.	18415665
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Quantitative MRD monitoring identifies distinct GVL response patterns after allogeneic stem cell transplantation for chronic lymphocytic leukemia: results from the GCLLSG CLL3X trial.	18418404
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	The purpose of this study was to prospectively analyze minimal residual disease(MRD) kinetics after reduced-intensity allogeneic stem cell transplantation (allo-SCT) in high-risk chronic lymphocytic leukemia (CLL).	18418404
Multiple Myeloma	Stem Cell Exhaustion	Impact of genetic abnormalities on survival after allogeneic hematopoietic stem cell transplantation in multiple myeloma.	18418408
Multiple Myeloma	Stem Cell Exhaustion	We analyzed the prognostic impact of the most frequent genetic abnormalities detected by fluorescence in situ hybridization in 101 patients with multiple myeloma, who underwent allogeneic hematopoietic stem cell transplantation (HSCT) after melphalan/fludarabine-based reduced conditioning.	18418408
leukemia	Stem Cell Exhaustion	Fludarabine/intermediate-dose cytarabine with or without allogeneic hematopoietic stem cell transplantation in poor-risk leukemia: a single center experience.	18418698
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Although preliminary only high-risk AML patients having a stem cell donor are candidates for fludarabine/intermediate-dose cytarabine and only those achieving a CR should be referred to subsequent allogeneic HSCT.	18418698
Degenerative polyarthritis	Stem Cell Exhaustion	Autologous synovial fluid enhances migration of mesenchymal stem cells from synovium of osteoarthritis patients in tissue culture system.	18418888
Pterygium	Stem Cell Exhaustion	Recurrent pterygium exhibits a more aggressive, fibrovascular growth pattern, leading to the corneal and conjunctival scarring and limbal stem cells deficiency.	18419105
Pancreatic carcinoma	Stem Cell Exhaustion	Sonic hedgehog derived from human pancreatic cancer cells augments angiogenic function of endothelial progenitor cells.	18422746
Pancreatic carcinoma	Stem Cell Exhaustion	When endothelial progenitor cells (EPC) isolated from human peripheral blood were cultured with supernatant from SHH-transfected 293 cells or pancreatic cancer cells, mRNA levels of vascular endothelial growth factor (VEGF), stromal cell-derived factor-1 and angiopoietin-1 were significantly increased, whereas no such induction was observed in human umbilical vein endothelial cell (HUVEC) and human dermal microvascular endothelial cell (HMVEC).	18422746
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	In the analysis of 11 CLL patients after allogeneic hematopoietic stem cell transplantation, 8 showed high values for OFA/iLR Abs that specifically recognized the extracellular domain of the protein, suggesting a potential role of anti-OFA/iLR-directed immune responses to the graft-vs-leukemia effect in CLL.	18424761
Liver carcinoma	Stem Cell Exhaustion	In this study, ezrin expression, as well as cytokeratin19 and cytokeratin 7 expression, which are regarded as progenitor cell/ductular markers were immunohistochemically assessed in cases of hepatocellular carcinoma.	18425081
Liver carcinoma	Stem Cell Exhaustion	Ezrin expression is associated with hepatocellular carcinoma possibly derived from progenitor cells and early recurrence after surgical resection.	18425081
Liver carcinoma, Neoplasms	Stem Cell Exhaustion	Patients with hepatocellular carcinoma probably derived from hepatic progenitor cells had early tumor recurrence after surgical resection or liver transplantation, suggesting that these tumors have aggressive characteristics.	18425081
Liver carcinoma	Stem Cell Exhaustion	These results suggested that hepatocellular carcinoma with ezrin expression might be at least partly derived from hepatic progenitor cells.	18425081
Specialty Type - cancer, HIV Infections, Parkinson Disease	Stem Cell Exhaustion	This report summarizes 10 cutting-edge areas of research covered in symposia that spanned such topics as stem cells, novel vaccine strategies, nutritional sensing, new concepts of Parkinson's disease, high throughput screening for aging interventions, manipulating telomerase in cancer and immunodeficiency, synergy between aging and HIV disease, and epigenetic influences on aging.	18426956
Glioma, Neoplasms	Stem Cell Exhaustion	Gliomas are heterogeneous tumours that grow in an uninhibited fashion, and these brain tumour cells share numerous characteristics with neural stem cells.	18427816
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation in patients of 70 years and older with multiple myeloma: Results from a matched pair analysis.	18429054
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	High-dose therapy and autologous stem cell transplant (HDT) have been shown to prolong survival in multiple myeloma (MM) in randomized trials, but only included patients of 65 years or younger.	18429054
Mediastinal (Thymic) Large B-Cell Lymphoma	Stem Cell Exhaustion	Primary mediastinal large cell lymphoma (PMBL): frontline treatment with autologous stem cell transplantation (ASCT).	18432630
Hypoxic-Ischemic Encephalopathy, Development International Birth Date	Stem Cell Exhaustion	To study the effect of hyperbaric oxygenation (HBO) on the differentiation of the implanted human neural stem cells (hNSCs) into neurons in neonatal rats following hypoxic-ischemic brain damage (HIBD).	18433546
Myelinolysis, Central Pontine, Acute lymphocytic leukemia	Stem Cell Exhaustion	Central pontine myelinolysis in a patient with acute lymphoblastic leukemia after hematopoietic stem cell transplantation: a case report.	18437020
Myelinolysis, Central Pontine, Acute lymphocytic leukemia	Stem Cell Exhaustion	We describe a 37-yr-old man who developed central pontine myelinolysis (CPM) after allogeneic hematopoietic stem cell transplantation (HSCT) for acute lymphoblastic leukemia.	18437020
PAFAH1B1 wt Allele	Stem Cell Exhaustion	The clonally expanded mtDNA mutations in MDS support the concept of age-related damage to mtDNA in hematopoietic stem cells.	18439489
FCGR1A gene	Stem Cell Exhaustion	Immunohistochemistry was used to identify the embryonic stem cell markers Octomer-4; stage-specific embryonic antigens 1, 3, and 4; TRA-1-60; and TRA-1-81, and the leukocytic markers CD34, CD14, CD133, and CD64 in all vessels.	18439939
Lymphoma	Stem Cell Exhaustion	High dose chemotherapy with autologous stem cell transplantation is currently the treatment of choice for relapsed or refractory lymphoma patients.	18443961
Hepatoblastoma	Stem Cell Exhaustion	Successful autologous peripheral blood stem cell transplantation with a double-conditioning regimen for recurrent hepatoblastoma after liver transplantation.	18444949
Cerebral Hemorrhage	Stem Cell Exhaustion	We found that neural stem/progenitor cell-specific protein markers were expressed in cells located in the perihematomal regions of the basal ganglia and parietal lobe of the adult human brain after primary intracerebral hemorrhage (n=5).	18446166
CLU protein, human, Ischemia	Stem Cell Exhaustion	The aim of the study was to test the potential effect of stem cell treatment in a strict defined group of patients with stable critical limb ischaemia (CLI).	18450207
Ischemia	Stem Cell Exhaustion	Treatment with autologous, bone marrow mononuclear stem cells has shown effects in patients with chronic limb ischaemia in one randomized clinical study.	18450207
GDC Comorbidity Terminology	Stem Cell Exhaustion	Toxicity-reduced conditioning is being used for allogeneic stem cell transplantation in older and/or comorbid patients.	18451310
Mantle cell lymphoma	Stem Cell Exhaustion	Effect of remission status and induction chemotherapy regimen on outcome of autologous stem cell transplantation for mantle cell lymphoma.	18452065
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	We analysed the outcomes of autologous stem cell transplantation (ASCT) following high-dose therapy with respect to remission status at the time of transplantation and induction regimen used in 56 consecutive patients with mantle cell lymphoma (MCL).	18452065
Premature Menopause	Stem Cell Exhaustion	The aim of this study was to isolate the putative ovarian stem cells (OSCs) from the OSE layer in women with no naturally present oocytes and follicles--20 postmenopausal women and five women with premature ovarian failure.	18452550
Adult Glioblastoma, Neoplasms	Stem Cell Exhaustion	We conclude that the primitive component of the MG-PNET: (i) arises within a pre-existing MG, most often a secondary glioblastoma; (ii) may represent a metaplastic process or expansion of a tumor stem/progenitor cell clone; (iii) often shows histologic anaplasia and N-myc (or c-myc) amplification; (iv) has the capacity to seed the CSF; and (v) may respond to platinum-based chemotherapy regimens.	18452568
Acute GVH disease	Stem Cell Exhaustion	Characterization of acute graft-versus-host disease following reduced-intensity stem-cell transplantation from an HLA-identical related donor.	18454459
Graft-vs-Host Disease, Hematologic Neoplasms, Acute GVH disease	Stem Cell Exhaustion	To investigate clinical features of acute graft-versus-host disease (GVHD) following reduced intensity stem-cell transplantation (RIST), we retrospectively investigated medical records of 65 patients with hematologic malignancies who underwent RIST from a matched related donor.	18454459
Cytomegalovirus Reactivation	Stem Cell Exhaustion	Monitoring cytomegalovirus IE-1 and pp65-specific CD4+ and CD8+ T-cell responses after allogeneic stem cell transplantation may identify patients at risk for recurrent CMV reactivations.	18454493
Neuronal and mixed neuronal-glial tumor	Stem Cell Exhaustion	These results indicate that the antibody HFB-16 could be a useful marker for neuronal tumors and primitive neuroectodermal tumors that may originate from immature neural progenitor cells.	18458818
Hair follicle structure	Stem Cell Exhaustion	Melanocyte stem cells have been recently localized in mice, in the outer root sheath of the lower permanent portion of the hair follicle.	18460306
melanoma	Stem Cell Exhaustion	Melanocyte stem cells also seem to drive the growth of malignant melanomas.	18460306
Tumor necrosis	Stem Cell Exhaustion	A reduced clonogenic capability and a decrease in the level of more primitive progenitor cells were observed in parallel with lower production of interleukin-2 and increased tumor necrosis factor-alpha levels.	18462177
Hematologic Neoplasms	Stem Cell Exhaustion	There is scarce information on the influence of stem cell transplantation (SCT) on the prognosis of patients with hematological malignancies admitted to an intensive care unit (ICU).	18462634
Malignant tumor of colon	Stem Cell Exhaustion	Graft-versus-tumor effect after reduced-intensity allogeneic hematopoietic stem cell transplantation in a patient with advanced colon cancer.	18463966
Malignant tumor of colon	Stem Cell Exhaustion	A 27-year-old man with advanced colon cancer that was resistant to conventional chemoradiotherapies was treated with reduced-intensity allogeneic peripheral blood stem cell transplantation (PBSCT).	18463966
Multiple Myeloma	Stem Cell Exhaustion	Effects of exercise in combination with epoetin alfa during high-dose chemotherapy and autologous peripheral blood stem cell transplantation for multiple myeloma.	18467280
Multiple Myeloma	Stem Cell Exhaustion	To determine the effect of aerobic and strength resistance training and epoetin alfa (EPO) therapy on transfusions, stem cell collections, transplantation recovery, and multiple myeloma treatment response.	18467280
Multiple Myeloma	Stem Cell Exhaustion	Number of red blood cell and platelet transfusions during transplantation, number of attempts at and total number of days of stem cell collection, time to recovery after transplantation, and response to intensive therapy for multiple myeloma.	18467280
Multiple Myeloma	Stem Cell Exhaustion	Exercise with prophylactic EPO therapy reduces the number of RBC transfusions and attempts at stem cell collection for patients receiving intensive treatment for multiple myeloma.	18467280
Kidney Failure	Stem Cell Exhaustion	Several case series and reports have suggested that high-dose chemotherapy with autologous peripheral blood stem-cell transplantation is efficacious treatment, but this transplantation is not indicated for elderly patients and patients with renal failure.	18469028
Acute leukemia	Stem Cell Exhaustion	Results of syngeneic hematopoietic stem cell transplantation for acute leukemia: risk factors for outcomes of adults transplanted in first complete remission.	18469352
Leukemia, Myelocytic, Acute, Acute lymphocytic leukemia	Stem Cell Exhaustion	We report the outcomes of a large series of adult patients who underwent syngeneic hematopoietic stem cell transplantation for acute myeloblastic leukemia or acute lymphoblastic leukemia.	18469352
Endometrial Carcinoma, Endometriosis	Stem Cell Exhaustion	Increased expression of the adult stem cell marker Musashi-1 in endometriosis and endometrial carcinoma.	18473332
Endometriosis, Endometrial Carcinoma, Endometrial Endometrioid Adenocarcinoma	Stem Cell Exhaustion	Our results emphasize the role of Musashi-1-expressing endometrial progenitor cells in proliferating endometrium, endometriosis and endometrioid uterine carcinoma, and support the concept of a stem cell origin of endometriosis and endometrial carcinoma.	18473332
Endometrial Carcinoma, Endometriosis	Stem Cell Exhaustion	Adult stem cells are thought to be responsible for the high regenerative capacity of the human endometrium, and have been implicated in the pathology of endometriosis and endometrial carcinoma.	18473332
Coronary Arteriosclerosis	Stem Cell Exhaustion	Bone-marrow derived endothelial progenitor cells (CD34+ and VEGFR2+ KDR+ EPC) and endothelial-derived microparticles (CD 31+Annexin V+, EMP; indicator for endothelial apoptosis) were examined in the peripheral blood of 35 male, clinically stable patients with 3-vessel coronary artery disease (CAD).	18474347
Specialty Type - cancer	Stem Cell Exhaustion	The zinc finger protein glioma-associated oncogene homologue 1 (Gli-1) is a critical component of the Hedgehog (Hh) signalling pathway, which is essential for morphogenesis and stem-cell renewal, and is dysregulated in many cancer types.	18475300
hydrochloride	Stem Cell Exhaustion	Distinct early- and late-onset HCL populations may reflect different age-related causal pathways, risk factor profiles, and/or stem cells of origin.	18477040
Uveal melanoma, Secondary Neoplasm	Stem Cell Exhaustion	Prognostic biomarkers in uveal melanoma: evidence for a stem cell-like phenotype associated with metastasis.	18477893
Specialty Type - cancer, Aggressive course, Secondary Neoplasm	Stem Cell Exhaustion	Taken together with the constellation of biomarkers associated with the class 2 signature, this suggests the presence of cancer cells with a primitive neural/ectodermal stem cell-like phenotype that may be responsible for metastasis in these highly aggressive tumors.	18477893
Neoplasms	Stem Cell Exhaustion	Importantly, Gene Set Enrichment Analysis showed a significant association between genes expressed in class 2 tumors and those expressed in primitive ectodermal and neural stem cells.	18477893
Neoplasms	Stem Cell Exhaustion	Tumor cells cultured under medium conditions favoring the growth of neural stem cells were able to form primary and secondary spheres, along with expression of neural stem/progenitor cell markers.	18478183
Liver carcinoma	Stem Cell Exhaustion	Expression and clinical significance of the stem cell marker CD133 in hepatocellular carcinoma.	18479363
Liver carcinoma, Specialty Type - cancer, Hollings Cancer Center	Stem Cell Exhaustion	Although the primitive haematopoietic and neuronal stem cell marker CD133 is known to be present in cancer stem cells (CSCs) in hepatocellular carcinoma (HCC), the postresection prognostic impact of CD133 in HCC patients remains limited.	18479363
beta Thalassemia	Stem Cell Exhaustion	Impact of pretransplant splenectomy on patients with beta-thalassemia major undergoing a matched-related allogeneic stem cell transplantation.	18482210
Inflammatory Bowel Diseases	Stem Cell Exhaustion	Hematopoietic stem cell transplantation in a CD3 gamma-deficient infant with inflammatory bowel disease.	18482219
Myeloid neoplasm	Stem Cell Exhaustion	Angiopoietin-2 predicts disease-free survival after allogeneic stem cell transplantation in patients with high-risk myeloid malignancies.	18483397
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We evaluated whether circulating angiopoietin-2 (Ang-2) is a predictor for the probability of disease-free survival (DFS) in allogeneic hematopoietic stem cell transplantation (allo-HSCT) for high-risk acute myeloid leukemia or myelodysplastic syndrome.	18483397
Infection, Immunocompromised Host	Stem Cell Exhaustion	Severe adenovirus (ADV) infections have become increasingly important in immunocompromised patients, mainly in pediatric stem cell transplant recipients.	18483646
Adenovirus Infections, Cessation of life	Stem Cell Exhaustion	We report a case of disseminated ADV infection leading to death in a 12-year-old stem cell transplant recipient.	18483646
Sample Size Calculation	Stem Cell Exhaustion	We report the successful use of nonmyeloablative allogeneic hematopoietic stem cell transplantation (HSCT) for SSc.	18483758
Scleroderma , Pneumonia, Interstitial	Stem Cell Exhaustion	A 40-year-old woman with diffuse scleroderma and interstitial pneumonia underwent allogeneic peripheral blood stem cell transplantation from an HLA-identical sibling after conditioning with low-dose total-body irradiation and fludarabine.	18483758
Acute lymphocytic leukemia	Stem Cell Exhaustion	Allogeneic hemopoietic stem cell transplantation for childhood acute lymphoblastic leukemia in second complete remission-similar outcomes after matched related and unrelated donor transplant: a study of the Spanish Working Party for Blood and Marrow Transplantation in Children (Getmon).	18484470
TCL4 gene	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation using reduced-intensity conditioning for adult T cell leukemia/lymphoma: impact of antithymocyte globulin on clinical outcome.	18489996
TCL4 gene, Adult T-Cell Lymphoma/Leukemia	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HSCT) is an effective treatment for adult T cell leukemia/lymphoma (ATLL), but shows high mortality.	18489996
Lymphoma, Follicular	Stem Cell Exhaustion	To investigate the impact of adding rituximab to intensive chemotherapy with peripheral-blood progenitor cell (PBPC) autograft for high-risk diffuse large B-cell lymphoma (DLB-CL) and follicular lymphoma (FL).	18490650
Colonization	Stem Cell Exhaustion	Oral and intestinal Candida colonization in patients undergoing hematopoietic stem-cell transplantation.	18491972
Colonization	Stem Cell Exhaustion	We investigated (1) the prevalence and quantity of, as well as risk factors for, orointestinal Candida colonization in patients undergoing hematopoietic stem-cell transplantation (HSCT) and (2) the genetic relatedness of colonizing C. albicans strains.	18491972
Lymphoma	Stem Cell Exhaustion	Germinal center B (GCB) and non-GCB cell-like diffuse large B cell lymphomas have similar outcomes following autologous haematopoietic stem cell transplantation.	18492096
Specialty Type - cancer	Stem Cell Exhaustion	We have compared gene expression in these cells relative to their normal and differentiated (CD133-/alpha2beta1low) counterparts, resulting in an informative cancer stem cell gene-expression signature.	18492237
Specialty Type - cancer	Stem Cell Exhaustion	Functional studies, using an inhibitor of nuclear factor kappaB (NF-kappaB), revealed preferential targeting of the cancer stem cell and progenitor population for apoptosis whilst sparing normal stem cells.	18492237
Prostate carcinoma	Stem Cell Exhaustion	Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions.	18492237
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	The tumor-initiating capacity of many cancers is considered to reside in a small subpopulation of cells (cancer stem cells).	18492237
Prostate carcinoma	Stem Cell Exhaustion	We have previously shown that rare prostate epithelial cells with a CD133+/alpha2beta1hi phenotype have the properties of prostate cancer stem cells.	18492237
Prostate carcinoma	Stem Cell Exhaustion	We describe an expression signature of 581 genes whose levels are significantly different in prostate cancer stem cells.	18492237
Specialty Type - cancer	Stem Cell Exhaustion	Functional annotation of this signature identified the JAK-STAT pathway and focal adhesion signaling as key processes in the biology of cancer stem cells.	18492237
Muscular Dystrophy, Duchenne	Stem Cell Exhaustion	Here we assessed whether the levels of certain stem cells may predict the progression of Duchenne muscular dystrophy (DMD).	18493616
Muscular Dystrophy, Duchenne	Stem Cell Exhaustion	The levels of several subpopulations of circulating stem cells expressing the CD133 antigen were determined by flow cytometry in 70 DMD patients.	18493616
Muscular Dystrophy, Duchenne	Stem Cell Exhaustion	The levels of CD133+CXCR4+CD34- stem cells were significantly higher in DMD patients compared to healthy controls (mean+/-standard deviation: 17.38+/-1.38 vs. 11.0+/-1.70; P = 0.03) with a tendency towards decreased levels in older patients.	18493616
Merkel cell carcinoma	Stem Cell Exhaustion	This morphology raises the possibility that Merkel cell carcinomas may arise from epidermal stem cells that can differentiate along different lines.	18494821
Anemia, Peripheral Stem Cell Transplantation, peripheral blood	Stem Cell Exhaustion	[CDR3 spectratyping and clonal expansion of peripheral blood T cells in a patient with beta-mediterranean anaemia following peripheral blood stem cell transplantation].	18495582
Anemia	Stem Cell Exhaustion	To study the CDR3 spectratyping and clonal expansion of T cells in the peripheral blood mononuclear cells (PBMCs) of patients with beta-mediterranean anemia patient undergoing allogeneic peripheral blood stem cell (PBSC) transplantation.	18495582
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We evaluated the impact of World Health Organization (WHO) classification and WHO classification-based Prognostic Scoring System (WPSS) on the outcome of patients with myelodysplastic syndrome (MDS) who underwent allogeneic stem cell transplantation (allo-SCT) between 1990 and 2006.	18497321
Pineal germinoma, Neoplasms	Stem Cell Exhaustion	Serum levels of alpha-fetoprotein, human chorionic gonadotropin and CA 125 were determined, and immunohistochemistry for CA 125 as well as the pluripotent stem cell markers AP-2gamma and Oct-3/4 was performed in tumor specimens and the NCC-IT human germinoma cell line.	18497549
Glioblastoma	Stem Cell Exhaustion	These findings suggest that in a subclass of glioblastomas the tumorigenic hit occurs on a multipotent stem cell, which may reveal its plasticity under specific environmental stimuli.	18497759
Adult Glioblastoma	Stem Cell Exhaustion	The discovery of such biological properties might provide considerable information to the development of new therapeutic strategies aimed at forcing glioblastoma stem cell differentiation.	18497759
Adult Glioblastoma	Stem Cell Exhaustion	Mesenchymal differentiation of glioblastoma stem cells.	18497759
Adult Glioblastoma, Specialty Type - cancer	Stem Cell Exhaustion	Although the tumorigenic population in glioblastoma is defined as composed by cancer stem cells (CSCs), the cellular target of the transformation hit remains to be identified.	18497759
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Glioma stem cells (SCs) are thought to have a differentiation potential restricted to the neural lineage.	18497759
Specialty Type - cancer, Glioblastoma	Stem Cell Exhaustion	Glioblastoma multiforme is a severe form of cancer most likely arising from the transformation of stem or progenitor cells resident in the brain.	18497759
Malignant Neoplasms	Stem Cell Exhaustion	Factors associated with successful mobilization of progenitor hematopoietic stem cells among patients with lymphoid malignancies.	18501104
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome, Acute leukemia	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disorder characterized by ineffective hematopoiesis and risk for evolving to acute leukemia.	18503825
PAFAH1B1 wt Allele	Stem Cell Exhaustion	FLT3, a member of the class 3 receptor tyrosine kinase family, mediates stem cell proliferation and differentiation, and its mutations, internal tandem duplication (ITD) and Asp835, have been reported in rare MDS patients.	18503825
Chronic myeloproliferative disorder	Stem Cell Exhaustion	In this study by using a cytofluorimetric analysis we evaluated circulating endothelial progenitor cells (EPCs) in patients with chronic myeloproliferative disease.	18504767
CRANIOMETAPHYSEAL DYSPLASIA, AUTOSOMAL DOMINANT, Polycythemia Vera, Primary Myelofibrosis, PMF Regimen	Stem Cell Exhaustion	In our patients, we have found an increase in the number of endothelial progenitor cells in primary myelofibrosis (PMF) and polycythaemia vera (PV) patients, while an increase of circulating endothelial cells (CECs) was found in all patients with CMD.	18504767
Multiple Myeloma	Stem Cell Exhaustion	Health-related quality of life in multiple myeloma survivors treated with high dose chemotherapy followed by autologous peripheral blood progenitor cell transplantation: a retrospective analysis.	18505348
Multiple Myeloma	Stem Cell Exhaustion	A pilot study analyses an effect of selected demographic, psychosocial and health aspects on quality of life (QoL) in multiple myeloma survivors treated with high-dose chemotherapy followed by autologous peripheral blood progenitor cell transplantation (PBPCT).	18505348
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Identical outcome after autologous or allogeneic genoidentical hematopoietic stem-cell transplantation in first remission of acute myelocytic leukemia carrying inversion 16 or t(8;21): a retrospective study from the European Cooperative Group for Blood and Marrow Transplantation.	18506024
TTN gene, Inflammation, Temporomandibular Joint Disorders	Stem Cell Exhaustion	Based on previous studies reporting that M-CSF/CSF-1 regulates the proliferation and differentiation of hemopoietic progenitor cells into mature macrophages, we put forward a new hypothesis based on the increased inflammation and tendency of females to suffer more from temporomandibular disorder (TMD) in the presence of external exacerbating factors.	18506373
Degenerative disorder of muscle	Stem Cell Exhaustion	Our study provides a proof of concept for a novel gene/stem cell therapy technique and opens another potential therapeutic approach for degenerative muscle disorders.	18511457
Epithelial	Stem Cell Exhaustion	Complete resurfacing of epithelial defects was apparent in 18 of 22 (82%) or in one of four (25%) eyes without or with limbal stem cell deficiency, respectively.	18511539
Epithelial, Neurotrophic keratitis	Stem Cell Exhaustion	Eye-drops containing FGLM-amide and SSSR induced the rapid resurfacing of persistent epithelial defects in stem cell-positive individuals with neurotrophic keratopathy.	18511539
Degenerative polyarthritis	Stem Cell Exhaustion	Synovial fluid mesenchymal stem cells in health and early osteoarthritis: detection and functional evaluation at the single-cell level.	18512779
BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 20, "cytidylyl-(3-5)-cytidine	Stem Cell Exhaustion	This decrease in CPC in obesity held true not only for the absolute cell numbers, but also for the relative fractions of KDR, CD133, and CD117 positive cells within the CD34 positive cells, indicating a specific down regulation of these progenitor cell types.	18515295
BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 20, Weight decreased	Stem Cell Exhaustion	Decreased number of circulating progenitor cells in obesity: beneficial effects of weight reduction.	18515295
Age related macular degeneration	Stem Cell Exhaustion	Late outgrowth endothelial progenitor cells in patients with age-related macular degeneration.	18515596
methyldopa	Stem Cell Exhaustion	To evaluate the feasibility of isolating and expanding endothelial progenitor cells (EPCs), in the form of late outgrowth endothelial progenitor cells (OECs), from the peripheral blood of an aged population, particularly patients affected by different forms of AMD.	18515596
Idiopathic pulmonary hypertension, Eisenmenger Complex	Stem Cell Exhaustion	Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension.	18519847
Endothelial dysfunction	Stem Cell Exhaustion	We speculated that PAH patients are deficient in circulating endothelial progenitor cells (EPCs), potentially contributing to endothelial dysfunction and disease progression.	18519847
Eisenmenger Complex, Down Syndrome	Stem Cell Exhaustion	The number of circulating CD34+, CD34+/AC133+, CD34+/KDR+, and CD34+/AC133+/KDR+ progenitor cells was low in Eisenmenger patients compared with healthy control subjects, and those with Down syndrome displayed even fewer EPCs.	18519847
Amyotrophic Lateral Sclerosis	Stem Cell Exhaustion	Bone marrow mesenchymal stem cells from healthy donors and sporadic amyotrophic lateral sclerosis patients.	18522229
Antilymphocyte Serum	Stem Cell Exhaustion	We analyzed expanded mesenchymal stem cells (MSCs) isolated from sporadic ALS patients and compared them with MSCs isolated from healthy donors.	18522229
Degenerative polyarthritis, Usual Severity Pain	Stem Cell Exhaustion	The described process of autologous mesenchymal stem cell culture and percutaneous injection into a knee with symptomatic and radiographic degenerative joint disease resulted in significant cartilage growth, decreased pain and increased joint mobility in this patient.	18523506
Degenerative polyarthritis	Stem Cell Exhaustion	Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells.	18523506
Usual Severity Pain	Stem Cell Exhaustion	This review will highlight the developments in cellular medicine that may soon permit interventional pain management physicians to treat a much wider variety of clinical conditions and highlight an interventional case study using these technologies To determine if isolated and expanded human autologous mesenchymal stem cells could effectively regenerate cartilage and meniscal tissue when percutaneously injected into knees.	18523506
Degenerative polyarthritis	Stem Cell Exhaustion	The mesenchymal stem cells were then percutaneously injected into the subject's knee with MRI proven degenerative joint disease.	18523506
Myocardial	Stem Cell Exhaustion	Release of biomarkers of myocardial damage after direct intramyocardial injection of genes and stem cells via the percutaneous transluminal route.	18524811
Myocardial, Coronary Arteriosclerosis	Stem Cell Exhaustion	We aimed to quantify the release of biomarkers of myocardial damage in relation to direct intramyocardial injections of genes and stem cells in patients with severe coronary artery disease.	18524811
Sample Size Calculation	Stem Cell Exhaustion	The lack of effect on increase of EPC confirms our previous findings of a defective endothelial stem cell recruitment in the bone marrow of SSc patients.	18528965
Vascular System Injuries, Sample Size Calculation	Stem Cell Exhaustion	To investigate whether statins may improve endothelial function in systemic sclerosis (SSc) by evaluating the effects of simvastatin on vasculogenesis [indicated by the expansion of circulating endothelial progenitor cells (EPC)] and the markers of vascular injury in the peripheral blood of patients with SSc.	18528965
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Thus, this study further supports the hypothesis that AML patients with poor survival may be related to having blasts with a biologically more immature or stem cell-like nature.	18534060
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Prognostic impact of pre-transplantation computed tomography and 67gallium scanning in chemosensitive diffuse large B cell lymphoma patients undergoing hematopoietic stem-cell transplantation.	18535875
B-Cell Lymphomas	Stem Cell Exhaustion	In the present study, we evaluated computed tomography (CT) and (67)gallium scanning ((67)Ga scan) pre-transplant as prognostic factors for overall survival (OS) and event-free survival (EFS) in patients with diffuse large B cell lymphoma, undergoing high-dose chemotherapy and stem-cell transplantation.	18535875
Hepatitis	Stem Cell Exhaustion	In experimental hepatitis, granulocyte-colony stimulating factor (G-CSF) mobilizes hematopoietic stem cells, induces liver regeneration, and improves survival.	18537187
Graft-vs-Host Disease, Malignant Neoplasms	Stem Cell Exhaustion	Although stem cell transplantation (SCT) is being used for hematopoietic reconstitution following high-dose chemotherapy for malignancy, it involves certain serious transplant-related complications such as graft-versus-host disease (GVHD).	18541195
Hematologic Neoplasms	Stem Cell Exhaustion	Patients older than 20 years undergoing myeloablative allogeneic stem cell transplantation (SCT) for hematologic malignancies were eligible.	18541197
Multiple Myeloma	Stem Cell Exhaustion	Stem cell mobilization with cyclophosphamide overcomes the suppressive effect of lenalidomide therapy on stem cell collection in multiple myeloma.	18541199
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Early lymphocyte recovery predicts superior survival after autologous stem cell transplantation in non-Hodgkin lymphoma: a prospective study.	18541201
Hematologic Neoplasms	Stem Cell Exhaustion	Day 15 absolute lymphocyte count (ALC-15) after autologous peripheral blood hematopoietic stem cell transplantation (APHSCT) has been reported to be a significant predictor for survival in multiple hematologic malignancies.	18541201
TCL4 gene, TRPV6 wt Allele, Graft vs Leukemia Effect	Stem Cell Exhaustion	A retrospective analysis of allogeneic hematopoietic stem cell transplantation for adult T cell leukemia/lymphoma (ATL): clinical impact of graft-versus-leukemia/lymphoma effect.	18541202
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Comorbidities, not age, impact outcomes in autologous stem cell transplant for relapsed non-Hodgkin lymphoma.	18541205
Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	High-dose chemotherapy followed by autologous peripheral blood stem cell transplantation is a widely applied treatment for advanced non-Hodgkin lymphoma (NHL), but few studies have analyzed the tolerability and outcomes in older patients compared with younger patients treated in a homogeneous manner.	18541205
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	We retrospectively reviewed 152 consecutive patients who underwent autologous stem cell transplantation (ASCT) following BEAM conditioning (carmustine, etoposide, cytarabine, and melphalan) for NHL from January 2000 through August 2004 at our institution.	18541205
Polycythemia Vera	Stem Cell Exhaustion	Circulating endothelial progenitor cells and residual in vivo thromboxane biosynthesis in low-dose aspirin-treated polycythemia vera patients.	18541722
Coronary heart disease	Stem Cell Exhaustion	[Change of endothelial progenitor cells from peripheral blood in patients with coronary heart diseases before and after percutaneous coronary intervention].	18544848
Coronary heart disease, altretamine/cisplatin/cyclophosphamide protocol	Stem Cell Exhaustion	To investigate the culture of endothelial progenitor cells (EPCs) from peripheral blood in patients with coronary heart diseases (CHD) before and after percutaneous coronary intervention (PCI), and to observe the cells shape and determine the cell number and proliferation activity.	18544848
Central neuroblastoma	Stem Cell Exhaustion	Between 1978 and 2006, the European Group for Blood and Marrow Transplantation registered 4098 high-dose therapy (HDT) procedures followed by stem cell rescue (SCR) (3974 autologous/124 allogeneic) in patients with neuroblastoma.	18545256
Tumor necrosis, Stem Cell Factor, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	AML cells were cultured according to four protocols that have been characterized in detail for AML-DC induction: (1) granulocyte-macrophage colony-stimulating factor (GM-CSF) + interleukin-4 (IL-4) days 1-14 and tumor necrosis factor-alpha (TNF-alpha) for days 6-14, (2) GM-CSF + IL-4 + TNF-alpha + FMS-like tyrosine kinase 3-ligand (Fl3-L) for 8 days, (3) GM-CSF + IL-4 + TNF-alpha + Flt3-L + stem cell factor (SCF) + transforming growth factor-beta1 (TGF-beta1) for 8 days, and (4) 25 Gy gamma-irradiation combined with culture in the presence of GM-CSF + SCF + IL-3 for 4 days.	18547160
methyldopa, Age related macular degeneration, Retinitis Pigmentosa	Stem Cell Exhaustion	To demonstrate efficacy and safety of the implantation of neural retinal progenitor cell layers (sheets) with its retinal pigment epithelium (RPE) in retinitis pigmentosa (RP) and dry age-related macular degeneration (AMD) patients with 20/200 or worse vision in the surgery eye.	18547537
Neoplasms	Stem Cell Exhaustion	The remaining 8 tumors did not contain small tumor cells with stem cell features (type 3).	18547618
Liver carcinoma, Neoplasms	Stem Cell Exhaustion	Small tumor cells with stem cell features in scirrhous hepatocellular carcinoma may correspond to side population of culture cells and might be involved in fibrogenesis of scirrhous hepatocellular carcinoma.	18547618
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells reportedly participate in the tumorigenesis of some neoplasms.	18547618
Liver carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Herein, we clinicopathologically examined scirrhous (29 cases) and conventional (50 cases) hepatocellular carcinoma with reference to cancer stem cells.	18547618
Liver carcinoma, Malignant neoplasm of liver	Stem Cell Exhaustion	Participation of liver cancer stem/progenitor cells in tumorigenesis of scirrhous hepatocellular carcinoma--human and cell culture study.	18547618
Cardiotoxicity, Multiple Myeloma	Stem Cell Exhaustion	Cardiac toxicity of high-dose cyclophosphamide and melphalan in patients with multiple myeloma treated with tandem autologous hematopoietic stem cell transplantation.	18548196
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Tandem autologous hematopoetic stem cell transplantation (HSCT) is an effective treatment in patients with multiple myeloma (MM).	18548196
Damage, Acute myocardial infarction	Stem Cell Exhaustion	Circulating endothelial progenitor cells are reported to associate with rescue of cardiac damage after acute myocardial infarction (AMI).	18549845
Alzheimers Disease	Stem Cell Exhaustion	Neural stem cells improve learning and memory in rats with Alzheimer's disease.	18550916
Up, "Alzheimers Disease	Stem Cell Exhaustion	We investigated whether neural stem cells (NSC) with transgenic expression of human nerve growth factor (hNGF) transplanted into the brain could offer a therapeutic option for the treatment of Alzheimer's disease (AD).	18550916
Up	Stem Cell Exhaustion	These genetically modified stem cells were grafted into the cerebral cortex of AD rats.	18550916
Toxic effect	Stem Cell Exhaustion	Treatment with high-dose melphalan with autologous stem cell support (HMAS) has a potential to increase survival, but is associated with toxicity and mortality.	18552900
atherosclerotic	Stem Cell Exhaustion	Osteoblasts might originate either from stem cells that penetrate atherosclerotic plaques from the blood stream or from pluripotent mesenchymal cells that have remained in the arterial wall from embryonic stages of the development.	18553107
palladium, Parkinson Disease	Stem Cell Exhaustion	Human neural stem cells offer the hope that a cell therapy treatment for Parkinson's disease (PD) could be made widely available.	18554088
Leukomalacia, Periventricular	Stem Cell Exhaustion	To evaluate the brain pathological changes following exdogenous neural stem cells (NSCs) intraventricular transplantation in neonatal rats with periventricular leukomalacia (PVL), and to explore the feasibility of NSCs transplantation for the treatment of PVL in premature infants.	18554469
Hyperbilirubinemia, Crigler Najjar syndrome, type 1	Stem Cell Exhaustion	Treatment of Crigler-Najjar Syndrome type 1 by hepatic progenitor cell transplantation: a simple procedure for management of hyperbilirubinemia.	18555136
Hyperbilirubinemia	Stem Cell Exhaustion	Herein we have reported a confirmed case of CNS type 1 in a 2-year-old girl with an unconjugated hyperbilirubinemia (>30 mg/dL) treated by hepatic progenitor cell infusion through the hepatic artery.	18555136
Hyperbilirubinemia	Stem Cell Exhaustion	This study demonstrated the efficacy of hepatic progenitor cells to manage hyperbilirubinemia in these patients.	18555136
Multiple Myeloma	Stem Cell Exhaustion	High dose chemotherapy and autologous stem cell transplantation in patients with multiple myeloma: the experience of a single haematological unit.	18555464
Malignant neoplasm of stomach	Stem Cell Exhaustion	We investigated whether the level of bone marrow-derived progenitor cells and mature endothelial cells could be used as predictors of clinical outcome in patients receiving taxotere-based chemotherapy for advanced gastric cancer.	18555590
Heart failure	Stem Cell Exhaustion	Effect of repeated intracoronary injection of bone marrow cells in patients with ischaemic heart failure the Danish stem cell study--congestive heart failure trial (DanCell-CHF).	18555742
Coronary Arteriosclerosis	Stem Cell Exhaustion	It has been suggested that myocardial regeneration may be achieved by a single intracoronary bone marrow derived stem cell infusion in selected patients with ischaemic heart disease.	18555742
Heart failure	Stem Cell Exhaustion	In this non-randomised study, no change in LV ejection fraction could be demonstrated after repeated intracoronary bone marrow stem cell treatment in patients with chronic ischaemic heart failure.	18555742
Heart failure	Stem Cell Exhaustion	To assess whether two treatments of intracoronary infusion of bone marrow stem cells, administered 4 months apart, could improve left ventricular (LV) systolic function in patients with chronic ischaemic heart failure.	18555742
Candidiasis	Stem Cell Exhaustion	Micafungin sodium is indicated for the prophylaxis of Candida infections in patients undergoing hematopoietic stem cell transplantation (HSCT).	18555943
Transplant-Related Malignant Neoplasm	Stem Cell Exhaustion	Long-term outcome after hematopoietic stem cell transplantation including late transplant-related events is of increasing interest.	18556401
Cardiovascular Agents	Stem Cell Exhaustion	Long-term survivors after allogeneic hematopoietic stem cell transplantation are likely to have an increased risk of premature cardiovascular accidents.	18556401
Systemic Scleroderma, Sample Size Calculation	Stem Cell Exhaustion	There is still controversy regarding the role of circulating endothelial and progenitor cells (CECs/CEPs) in the pathogenesis of systemic sclerosis (SSc).	18556411
Sample Size Calculation	Stem Cell Exhaustion	Using a sequential Boolean gating strategy based on a 4-color flow cytometric protocol, an increased number of CD31(pos)/CD184(pos)(CXCR4)/CD34(pos)/CD45(pos) and CD31(pos)/CD117(pos) (c-kit-R) /CD34(pos)/ CD45(pos) hematopoietic circulating progenitor cells (HCPCs) was detected in SSc patients compared with healthy subjects.	18556411
Sample Size Calculation	Stem Cell Exhaustion	In SSc, no circulating mature and progenitor endothelial cells were observed, while an enhanced generation of erythroid progenitor cells was found to be correlated with the presence of CD117+ HCPCs.	18556411
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukemia (AML) is a clinically and molecularly heterogeneous disease characterized by the aberrant proliferation of myeloid stem cells, reduced apoptosis and blockage in cellular differentiation.	18558290
Childhood Breast Carcinoma, Neoplasms	Stem Cell Exhaustion	Breast cancer cells with a CD44+/CD24- phenotype have been suggested to have tumor-initiating properties with stem cell-like and invasive features, although it is unclear whether their presence within a tumor has clinical implications.	18559090
Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	Not all basal-like tumors and very few HER2+ tumors, however, contain CD44+/CD24- cells, emphasizing that a putative tumorigenic ability may not be confined to cells of this phenotype and that other breast cancer stem cell markers remain to be identified.	18559090
Lymphoma, Follicular	Stem Cell Exhaustion	The treatment of patients with follicular lymphoma has changed with the introduction of high-dose therapy (HDT) with autologous stem-cell transplant then with rituximab.	18559872
Physical activity	Stem Cell Exhaustion	Mesencephalic human neural progenitor cells transplanted into the adult hemiparkinsonian rat striatum lack dopaminergic differentiation but improve motor behavior.	18560206
Specialty Type - cancer	Stem Cell Exhaustion	These findings raise an attractive hypothesis that GBMs can be cured by eradicating CD133-positive cancer stem cells (CSCs), which are a small portion of GBM cells.	18560366
Central neuroblastoma	Stem Cell Exhaustion	Using RNAi, we created stable PINK1 knockdown in human dopaminergic neurons differentiated from foetal ventral mesencephalon stem cells, as well as in an immortalised human neuroblastoma cell line.	18560593
Rheumatoid Arthritis, Degenerative polyarthritis	Stem Cell Exhaustion	Chondrogenic potential of mesenchymal stem cells from patients with rheumatoid arthritis and osteoarthritis: measurements in a microculture system.	18562787
B-Cell Lymphomas	Stem Cell Exhaustion	Disease staging with positron emission tomography or gallium scanning and use of rituximab predict outcome for patients with diffuse large B-cell lymphoma treated with autologous stem cell transplantation.	18564354
Neoplasms, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Tumor status, as determined by positron emission tomography or gallium scanning (PET/G), may be an important predictor of outcome for patients with diffuse large B-cell lymphoma (DLBCL) undergoing autologous stem cell transplantation (ASCT).	18564354
Adult Glioblastoma	Stem Cell Exhaustion	Stem cell-related "self-renewal" signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma.	18565887
Glioblastoma Multiforme Pathway, Adult Glioblastoma	Stem Cell Exhaustion	This study provides first clinical evidence for the implication of a "glioma stem cell" or "self-renewal" phenotype in treatment resistance of glioblastoma.	18565887
Acute lymphocytic leukemia, Myeloid Leukemia, Chronic, Leukemia, Myelocytic, Acute, BCR gene	Stem Cell Exhaustion	The RR was greatest among survivors of stem-cell transplantation for acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), and chronic myelogenous leukemia (RR = 26.9, 66.5, and 93.1, respectively).	18565890
Choroidal Neovascularization, Myopia	Stem Cell Exhaustion	Circulating hematopoietic stem cells in patients with choroidal neovascularization secondary to pathologic myopia.	18566608
Choroidal Neovascularization	Stem Cell Exhaustion	Emerging evidences suggest that circulating hematopoietic stem cells (HSCs) affect the pathogenesis of choroidal neovascularization (CNV), however, the roles of HSCs in CNV remain unclear in human population.	18566608
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	ESHAP (etoposide/methylprednisolone/cytarabine/cisplatin) plus granulocyte-colony stimulating factor (G-CSF) is an effective regimen of therapy for advanced non-Hodgkin's lymphoma (NHL) and peripheral blood progenitor cell (PBPC) mobilization.	18567557
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Predictors for successful mobilization of peripheral blood progenitor cells with ESHAP + G-CSF in patients with pretreated non-Hodgkin's lymphoma.	18567557
Inflammation, Endothelial dysfunction	Stem Cell Exhaustion	Granulocyte-colony stimulating factor (G-CSF) is used for the mobilization of bone marrow and endothelial progenitor cells, though G-CSF-induced inflammation may cause endothelial dysfunction.	18569019
Scleromyxedema	Stem Cell Exhaustion	Transient efficacy of double high-dose chemotherapy and autologous peripheral stem cell transplantation, immunoglobulin, thalidomide, and bortezomib in the treatment of scleromyxedema.	18572979
Scleromyxedema	Stem Cell Exhaustion	We present the case of a 38-year-old male patient with scleromyxedema who underwent double consecutive autologous peripheral stem cell transplantations and received immunoglobulin, thalidomide, and bortezomib.	18572979
Specialty Type - cancer	Stem Cell Exhaustion	Beneficial effects of fetal-maternal microchimerism on the activated haplo-identical peripheral blood stem cell treatment for cancer.	18574766
Neoplasms	Stem Cell Exhaustion	Background Previous studies have shown that activated haplo-identical peripheral blood stem cell (haplo-PBSC) treatment exerts an anti-tumor effect on patients with metastatic solid tumors.	18574766
Heart failure	Stem Cell Exhaustion	Increased expression of stem cell factor and its receptor after left ventricular assist device support: a potential novel target for therapeutic interventions in heart failure.	18582797
Heart failure, Stem Cell Factor	Stem Cell Exhaustion	This study investigates the potential role of stem cell factor (SCF) and its receptor (c-Kit) in promoting the recruitment of mast cells during heart failure and after LVAD support.	18582797
Osteoporosis	Stem Cell Exhaustion	Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis.	18583541
cytidylyl-(3-5)-cytidine	Stem Cell Exhaustion	Transplantation of circulating progenitor cells (CPC) improves left ventricular function after successful recanalisation of chronic total occlusions at short-term follow-up.	18584897
Degenerative polyarthritis	Stem Cell Exhaustion	We examined the mRNA levels of hypoxia-inducible factor-1alpha (HIF-1alpha) in bone marrow mesenchymal stem cells (bmMSCs) of eight osteoarthritis patients.	18588890
Cardiotoxicity	Stem Cell Exhaustion	Cardiac systolic function in patients receiving hematopoetic stem cell transplantation: risk factors for posttransplantation cardiac toxicity.	18589156
Cardiotoxicity	Stem Cell Exhaustion	One hundred eleven patients who received 125 hematopoetic stem cell transplantations (HSCT) with myeloablative conditioning regimens were retrospectively evaluated for the development of cardiac toxicity (CT).	18589156
Vascular Diseases	Stem Cell Exhaustion	Circulating endothelial progenitor cell numbers are not associated with donor organ age or allograft vasculopathy in cardiac transplant recipients.	18589426
Retinal Degeneration	Stem Cell Exhaustion	Stem cells as prospective therapeutic tools for retinal degeneration.	18592437
Endometrial Carcinoma	Stem Cell Exhaustion	[The plasma levels and diagnostic utility of stem cell factor and macrophage--colony stimulating factor in endometrial cancer patients].	18595499
Childhood Breast Carcinoma, Stem Cell Factor	Stem Cell Exhaustion	[Stem cell factor (SCF) in the plasma and phagocytic functions of granulocytes in breast cancer patients].	18595506
Stem Cell Factor	Stem Cell Exhaustion	Stem Cell Factor (SCF) is a cytokine which stimulates the growth and development of primitive multipotential and unipotential hematopoietic stem cells in vitro and in vivo either alone or in combination with other cytokines such as Granulocyte-Macrophage Colony Stimulating Factor and Granulocyte Colony Stimulating Factor.	18595506
Myositis	Stem Cell Exhaustion	Endothelial and myogenic differentiation of hematopoietic progenitor cells in inflammatory myopathies.	18596542
Fibrous Dysplasia	Stem Cell Exhaustion	Age-dependent demise of GNAS-mutated skeletal stem cells and "normalization" of fibrous dysplasia of bone.	18597624
Somatic mosaicism, Fibrous Dysplasia, Dysautonomia, Familial	Stem Cell Exhaustion	We studied the role of somatic mosaicism in fibrous dysplasia of bone (FD) within the context of skeletal ("mesenchymal") stem cells by assessing the frequency of mutated colony forming unit-fibroblasts (CFU-Fs) from FD lesions, and in some cases, from unaffected sites, in a series of patients.	18597624
Muscular Dystrophy	Stem Cell Exhaustion	Early transplantation of human immature dental pulp stem cells from baby teeth to golden retriever muscular dystrophy (GRMD) dogs: Local or systemic?	18598348
Hematologic Neoplasms	Stem Cell Exhaustion	Mobilization of peripheral blood stem cells for autologous transplantation patients with hematological malignancies: Influence of disease, mobilization method, age and sex.	18599353
Hematological Disease	Stem Cell Exhaustion	Autologous peripheral blood stem cells transplantation (Auto-PBSCT) is a therapeutic option which can be used in various hematological neoplastic disorders; and it can prolong disease-free survival and total survival.	18599353
Hematologic Neoplasms	Stem Cell Exhaustion	In this study, we investigated the variables influencing the mobilization of peripheral blood stem cells in 240 patients with hematological malignancies who had undergone Auto-PBSCT between 2001 and March 2007 in our center, retrospectively.	18599353
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	Stem Cell Exhaustion	Circulating endothelial progenitor cells in patients with ANCA-associated vasculitis.	18600027
Blood Vessel	Stem Cell Exhaustion	Bone marrow-derived endothelial progenitor cells (EPCs) are believed to contribute to endothelial repair after vascular damage.	18600027
Gastrointestinal Stromal Tumors, Neoplasms	Stem Cell Exhaustion	Expression of stem cell factor (SCF), a KIT ligand, in gastrointestinal stromal tumors (GISTs): a potential marker for tumor proliferation.	18602222
Neoplasms	Stem Cell Exhaustion	Some mesenchymal and epithelial tumors have been reported to co-express KIT and its ligand, stem cell factor (SCF), for autonomous proliferation by the autocrine mechanism.	18602222
Vascular System Injuries	Stem Cell Exhaustion	Recent studies indicate that platelets influence endothelial progenitor cell (EPC) recruitment to sites of vascular injury and promote their differentiation to an endothelial phenotype.	18604625
B-Cell Lymphomas	Stem Cell Exhaustion	Salvage chemotherapy and autologous stem cell transplantation are inferior for relapsed or refractory primary mediastinal large B-cell lymphoma compared with diffuse large B-cell lymphoma.	18604722
B-Cell Lymphomas	Stem Cell Exhaustion	Ifosfamide, epirubicin and etoposide rituximab in refractory or relapsed B-cell lymphoma: analysis of remission induction and stem cell mobilization.	18604723
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	The addition of rituximab to IEV salvage chemotherapy increases the response rates in B-cell NHL without affecting stem cell mobilization, but overall survival for patients proceeding to high-dose chemotherapy is not improved.	18604723
Oocytes, ovarian neoplasm	Stem Cell Exhaustion	In conclusion, the discovered cells expressed embryonic stem cell markers, gave rise to embryoid body-, oocyte-, and blastocyst-like structures, and might be involved in the human reproduction and formation of ovarian tumors.	18605894
Acute leukemia	Stem Cell Exhaustion	A survey of fully haploidentical hematopoietic stem cell transplantation in adults with high-risk acute leukemia: a risk factor analysis of outcomes for patients in remission at transplantation.	18606875
Acute leukemia	Stem Cell Exhaustion	Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is an alternative treatment to patients with high-risk acute leukemia lacking a human leukocyte antigen-matched donor.	18606875
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	A total of 152 patients with myelodysplastic syndrome (MDS) receiving a first stem cell transplant had marrow cells prospectively analyzed to calculate the flow cytometric scoring system (FCSS) score.	18606877
Multiple Myeloma	Stem Cell Exhaustion	The role of stem cell mobilization regimen on lymphocyte collection yield in patients with multiple myeloma.	18608354
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The lymphocyte dose (LY-DO) infused during an autograft influences absolute lymphocyte (ALC) recovery and survival following autologous stem cell transplantation (ASCT) in multiple myeloma (MM) patients.	18608354
Mycoses	Stem Cell Exhaustion	Due to unacceptably high mortality, invasive fungal infections (IFI) have long been considered a contraindication against allogeneic stem cell transplantation.	18608932
Neoplasms, Astrocytoma	Stem Cell Exhaustion	The aim of the present study was to investigate the localization and distribution of the putative brain tumour stem cell marker CD133 in formalin fixed paraffin embedded astrocytomas.	18612800
Astrocytoma	Stem Cell Exhaustion	In conclusion, a CD133(+) perivascular stem cell-like entity exists in astrocytomas.	18612800
Neoplasms	Stem Cell Exhaustion	CD133(+) tumour vessels may play an important role in a brain tumour stem cell context, while CD133 alone does not appear to be a specific tumour stem cell marker related to patient survival.	18612800
Hematologic Neoplasms	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation provides curative therapy for some patients with advanced hematologic malignancies.	18614230
Leukemia, Myelomonocytic, Chronic, Reactive monocytosis	Stem Cell Exhaustion	Hematopoietic progenitor cell colony growth differentiates chronic myelomonocytic leukemia from reactive monocytosis.	18616511
Peripheral Blood Stem Cells, Myeloid Leukemia	Stem Cell Exhaustion	A 31-year-old female with refractory extramedullary myeloid leukemia relapse underwent peripheral blood stem-cell transplantation from her HLA-identical brother.	18616875
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Erlotinib and gefitinib were equipotent in inducing apoptosis of primary CD34+ myeloblasts from MDS and AML patients, yet had no toxic effect on CD34+ progenitor cells from healthy donors.	18617157
Secondary malignant neoplasm of lung	Stem Cell Exhaustion	Therapeutic potential of mesenchymal stem cells producing interferon-alpha in a mouse melanoma lung metastasis model.	18617688
Specialty Type - cancer	Stem Cell Exhaustion	Adult stem cells represent a potential source for cell-based therapy of cancer.	18617688
melanoma, Secondary Neoplasm	Stem Cell Exhaustion	The present study evaluated the potential of bone marrow-derived mesenchymal stem cells (MSC), genetically modified to express interferon (IFN)-alpha, for the treatment of lung metastasis in an immunocompetent mouse model of metastatic melanoma.	18617688
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Hematopoietic stem cell transplant (HSCT) was planned for all high risk AML patients in first complete remission (CR) after consolidation with intermediate doses of Ara-C and idarubicin (IDAC-IDA).	18621416
Mantle cell lymphoma, Lymphoma	Stem Cell Exhaustion	Long-term progression-free survival of mantle cell lymphoma after intensive front-line immunochemotherapy with in vivo-purged stem cell rescue: a nonrandomized phase 2 multicenter study by the Nordic Lymphoma Group.	18625886
Medial collateral ligament	Stem Cell Exhaustion	Intensive immunochemotherapy with in vivo purged stem cell support can lead to long-term progression-free survival of MCL and perhaps cure.	18625886
Hematologic Neoplasms	Stem Cell Exhaustion	In a phase II multicentric prospective trial, we investigated the safety and feasibility of the treosulfan-fludarabine combination prior to allogeneic hematopoietic stem cell transplant in patients with various hematological malignancies not eligible for conventional regimens because of previous intensive treatment, older age, and comorbidities.	18626885
Venous Thromboembolism	Stem Cell Exhaustion	Incidence of symptomatic venous thromboembolism following hematopoietic stem cell transplantation.	18627443
Venous Thromboembolism, vinyltriethoxysilane	Stem Cell Exhaustion	The incidence of symptomatic venous thromboembolism (VTE) following hematopoietic stem cell transplantation (HSCT) is not well described, particularly with increased use of ambulatory care in the transplant setting.	18627443
Communicable Diseases	Stem Cell Exhaustion	Despite advances in surveillance strategies and antivirals, cytomegalovirus (CMV) infection continues to pose problems to patients receiving hematopoietic stem cell transplants (HSCTs).	18627578
Post-transplant lymphoproliferative disorder, Virus Diseases	Stem Cell Exhaustion	We summarize the experience of our hospital, one of Spain's largest series of renal (294), liver (47) and allogeneic stem cell transplants (67), where four cases of PTLD have developed related to complex viral infections.	18628071
Acute lymphocytic leukemia	Stem Cell Exhaustion	Case 1 was a 24-month-old boy diagnosed with acute lymphoblastic leukemia who underwent allogeneic stem-cell transplantation (SCT).	18628071
Mandible	Stem Cell Exhaustion	Maxillofacial-derived stem cells regenerate critical mandibular bone defect.	18636943
Communicable Diseases	Stem Cell Exhaustion	The high frequency of oncogenic HPV types implicates maternal transmission of HPV and infection of an ectodermal stem cell leading to an epigenetic mosaic and altered skin development manifested along Blaschko's lines.	18638629
Graft-vs-Host Disease	Stem Cell Exhaustion	Sirolimus, tacrolimus, and low-dose methotrexate as graft-versus-host disease prophylaxis in related and unrelated donor reduced-intensity conditioning allogeneic peripheral blood stem cell transplantation.	18640576
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	We assessed the combination of sirolimus, tacrolimus, and low-dose methotrexate as acute graft-versus-host disease (aGVHD) prophylaxis after reduced-intensity conditioning (RIC) allogeneic peripheral blood stem cell (PBSC) transplantation from matched related (MRD, n = 46) and unrelated (URD, n = 45) donors.	18640576
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Within the past decades, major advances in therapy for chronic myelocytic leukemia, including allogeneic hematopoietic stem cell transplantation, interferon therapy, and, more recently, also therapy with the tyrosine kinase inhibitor imatinib, have entered clinical practice.	18641022
Multiple Myeloma	Stem Cell Exhaustion	Clinical impact of human Jurkat T-cell-line-derived antithymocyte globulin in multiple myeloma patients undergoing allogeneic stem cell transplantation.	18641030
Graft-vs-Host Disease	Stem Cell Exhaustion	Antithymocyte globulin or human Jurkat T-cell-line-derived antilymphocyte globulin is used in allogeneic stem cell transplantation to induce in vivo T-cell depletion to facilitate engraftment and lower graft-versus-host disease.	18641030
Graft-vs-Host Disease, Multiple Myeloma	Stem Cell Exhaustion	We evaluated the anti-myeloma activity of antilymphocyte globulin in a melphalan/fludarabine-based reduced intensity conditioning regimen as well as the incidence of graft-versus-host disease in 138 multiple myeloma patients who underwent allogeneic stem cell transplantation with (n=79) or without (n=59) antilymphocyte globulin.	18641030
Graft-vs-Host Disease, Multiple Myeloma	Stem Cell Exhaustion	Inclusion of antithymocyte globulin in allogeneic stem cell transplantation protocols for patients with multiple myeloma may increase remission rates and at the same time prevent graft-versus-host disease with no increase of relapses.	18641030
Hematologic	Stem Cell Exhaustion	Antifungal combination therapy is feasible and efficient in haematological cancer patients and allogeneic stem cell transplant recipients with IFI.	18641986
Kidney Failure, Chronic	Stem Cell Exhaustion	The role of mesenchymal stem cells in the functional improvement of chronic renal failure.	18647091
Acute kidney injury	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) have shown to improve outcome of acute renal injury models.	18647091
Multiple Myeloma	Stem Cell Exhaustion	Thalidomide maintenance following high-dose melphalan with autologous stem cell support in myeloma.	18650178
Multiple Myeloma	Stem Cell Exhaustion	Thirty-eight patients with myeloma were enrolled and treated with melphalan 200 mg/m(2) followed by autologous stem cell transplantation.	18650178
Lymphoma of kidney, Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	Successful autologous peripheral blood stem cell transplantation for a patient with primary adrenal lymphoma with hemophagocytic syndrome.	18650184
MRSA - Methicillin resistant Staphylococcus aureus infection, Meningoencephalitis	Stem Cell Exhaustion	Successful treatment of meningoencephalitis caused by methicillin-resistant Staphylococcus aureus with intravenous linezolid in an allogeneic cord blood stem cell transplant recipient.	18651266
MRSA - Methicillin resistant Staphylococcus aureus infection, Pathogenic organism	Stem Cell Exhaustion	Methicillin-resistant Staphylococcus aureus (MRSA) is an infectious pathogen that commonly occurs after stem cell transplantation.	18651266
Vascular System Injuries	Stem Cell Exhaustion	Endothelial progenitor cells (EPC) have been shown to have a prominent role in re-endothelialization and repair following vascular injury.	18651648
melanoma	Stem Cell Exhaustion	Some LRCs, but not all, colocalized with cells expressing melanoma chondroitin sulfate proteoglycan, a putative stem cell marker.	18653773
Neutropenia, Hematologic Neoplasms, Fever	Stem Cell Exhaustion	Levels of several biomarkers were measured in patients with hematological malignancy at diagnosis and at the beginning of neutropenia due to cytostatic treatment or after hematopoietic stem cell transplantation, and daily until 6 days after presenting fever.	18661397
Acute myocardial infarction	Stem Cell Exhaustion	Effect of intensive vs standard statin therapy on endothelial progenitor cells and left ventricular function in patients with acute myocardial infarction: Statins for regeneration after acute myocardial infarction and PCI (STRAP) trial.	18667247
Myocardial Ischemia	Stem Cell Exhaustion	This could be related to the ability of statins to increase levels of Endothelial Progenitor Cells (EPCs), which were demonstrated to be favorably associated with a better prognosis and post-infarction left ventricular remodeling in patients with ischemic heart disease.	18667247
Malignant Lesion	Stem Cell Exhaustion	[Expression and significance of prostate stem cell antigen and Oct-4 in benign and malignant lesions of the stomach].	18667777
Malignant Lesion	Stem Cell Exhaustion	To determine on the expression of prostate stem cell antigen (PCSA )and Oct-4 and detect their clinicopathological significance in benign and malignant lesions of the stomach.	18667777
Graft-vs-Host Disease	Stem Cell Exhaustion	Hematopoetic stem cell transplantation may be complicated by genital graft-versus-host (GVH) disease and may uncommonly result in labial fusion.	18669755
Ewings sarcoma, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 22-year-old woman with a history of Ewing's sarcoma and acute myelogenous leukemia received chemotherapy and total-body irradiation followed by a matched, unrelated donor hematopoetic stem cell transplantation.	18669755
Chief complaint (finding), Acute GVH disease	Stem Cell Exhaustion	Genital GVH disease should be considered in women with genital tract complaints after hematopoetic stem cell transplantation.	18669755
Antilymphocyte Serum	Stem Cell Exhaustion	Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons.	18669821
Antilymphocyte Serum	Stem Cell Exhaustion	These patient-specific iPS cells possess properties of embryonic stem cells and were successfully directed to differentiate into motor neurons, the cell type destroyed in ALS.	18669821
Multiple Myeloma	Stem Cell Exhaustion	Multiparameter flow cytometric remission is the most relevant prognostic factor for multiple myeloma patients who undergo autologous stem cell transplantation.	18669875
Specialty Type - cancer	Stem Cell Exhaustion	Cancer patients receiving chemotherapy or a Stem Cell Transplantation (SCT) are in need of information about their disease, treatment options and side effects.	18675526
Liver diseases	Stem Cell Exhaustion	[Autologous bone marrow stem cell transplantation for treatment terminal liver diseases].	18676264
Liver Failure, Liver Cirrhosis	Stem Cell Exhaustion	To evaluate the effect of autologous bone marrow-derived stem cell (BMSCs) transplantation in the treatment of liver failure and decompensated hepatic cirrhosis.	18676264
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	We hypothesized that PBSC mobilization using an intensive chemotherapy regimen would improve outcomes after autologous hematopoietic stem cell transplantation (ASCT) in NHL patients at high risk for relapse.	18679366
Glioblastoma Multiforme Pathway, Specialty Type - cancer	Stem Cell Exhaustion	Bromodeoxyuridine also impairs the proliferative capacity of primary tumor-initiating human glioma cells and may therefore represent a means of targeting cancer stem cells.	18680882
Rheumatoid Arthritis	Stem Cell Exhaustion	Endothelial progenitor cells and colony-forming units in rheumatoid arthritis: association with clinical characteristics.	18682413
Rheumatoid Arthritis	Stem Cell Exhaustion	To compare levels of a range of endothelial progenitor cells (EPCs) and endothelial colony-forming units (CFUs) in control participants and RA patients, in addition to verifying whether levels of EPCs or CFUs are associated with clinical characteristics in RA patients.	18682413
HD Term Type, "Huntingtons Disease Pathway	Stem Cell Exhaustion	The present investigation examined the neuroprotective benefits for combined trehalose administration with C17.2 neural stem cell transplantation in a transgenic mouse model of Huntington's disease (HD), R6/2.	18683244
Huntingtons Disease Pathway	Stem Cell Exhaustion	Intracerebral transplantation of neural stem cells combined with trehalose ingestion alleviates pathology in a mouse model of Huntington's disease.	18683244
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	A graft-versus-lymphoma effect against diffuse large B-cell lymphoma (DLBCL) is inferred by sustained relapse-free survival after allogeneic stem-cell transplantation; however, there are limited data on a direct graft-versus-lymphoma effect against DLBCL following immunotherapeutic intervention by either withdrawal of immunosuppression or donor lymphocyte infusion (DLI).	18684698
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	The analysis was restricted to patients with DLBCL, who were either not in complete remission at day +100 after allogeneic stem-cell transplantation or subsequently relapsed beyond this time point.	18684698
Hypertension, CTCAE	Stem Cell Exhaustion	Renal expression of stem cell factor was markedly upregulated in primary hypertension.	18684889
Hypertensive disease	Stem Cell Exhaustion	In conclusion, human hypertensive kidney disease shows an early and conspicuous upregulation of stem cell factor along with an increased number of mature mast cells.	18684889
Chronic kidney disease stage 5, Histiocytoid Cardiomyopathy, Specialty Type - cancer, Acquired Immunodeficiency Syndrome	Stem Cell Exhaustion	Chronically ill children were: (1) attending outpatient clinics and (2) had one of the following diagnoses: stem cell transplant, chronic obstructive pulmonary disease, HIV/AIDS, cancer, end stage renal disease, complex congenital cardiopathy.	18687134
Pulmonary Aspergillosis, Communicable Diseases	Stem Cell Exhaustion	First case of breakthrough pulmonary Aspergillus niveus infection in a patient after allogeneic hematopoietic stem cell transplantation.	18687556
Pulmonary Aspergillosis, Fanconi Anemia	Stem Cell Exhaustion	This is the 1st report on a pulmonary breakthrough aspergillosis caused by A. niveus in a 21-year-old woman after allogeneic hematopoietic stem cell transplantation for Fanconi anemia.	18687556
Chronic Kidney Disease, CTCAE	Stem Cell Exhaustion	The HLA data of 1,800 potential cadaveric kidney transplantation recipients in the waiting list as chronic kidney disease control and 1,500 potential bone marrow stem cell donors in national stem cell registry as healthy population control were retrieved from the database of Thai Red Cross for comparison.	18689790
Pure Red-Cell Aplasia	Stem Cell Exhaustion	There was a significant difference of HLA-DRB109 gene frequency (P < 0.001) which associated with HLA-DQB10309 between anti-r-HuEpo associated PRCA cases, and potential cadaveric kidney transplantation in the waiting list or potential national stem cell registry donor.	18689790
Amyloidosis	Stem Cell Exhaustion	Predictors of survival in patients with systemic light-chain amyloidosis and cardiac involvement initially ineligible for stem cell transplantation and treated with oral melphalan and dexamethasone.	18691169
Childhood Breast Carcinoma	Stem Cell Exhaustion	This analysis reveals two breast cancer subgroups with stem cell-like features, differing in ER-status and proliferation as well as in their clinical course of disease.	18691884
Childhood Breast Carcinoma	Stem Cell Exhaustion	Differentially expressed genes of reprogrammed human pluripotent stem cells in breast cancer.	18691884
Childhood Breast Carcinoma	Stem Cell Exhaustion	We analysed genes recently shown to be differentially expressed in induced pluripotent stem cells (iPS) in 95 breast cancer samples.	18691884
Inflammation	Stem Cell Exhaustion	This is supported by the negative association between plaque inflammation and circulating progenitor cells before endarterectomy.	18692349
Acute leukemia	Stem Cell Exhaustion	Adult patients with acute leukaemia, for whom an unrelated stem-cell transplantation was indicated and no suitable unrelated human leucocyte antigen (HLA)-matched donor had been identified, were included in the study and underwent a cord-blood transplant in San Martino Hospital, Genoa, Italy.	18693069
Hepatic Veno-Occlusive Disease	Stem Cell Exhaustion	Hepatic veno-occlusive disease after tandem autologous stem cell transplantation conditioned by melphalan.	18696182
Multiple Myeloma	Stem Cell Exhaustion	We report the case of a 58-year-old man with multiple myeloma stage III A who received tandem autologous stem cell transplantation after induction by two courses of VAD and three cycles of bortezomib-dexamethasone, due to progression under chemotherapy.	18696182
B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1	Stem Cell Exhaustion	Case of a patient with Philadelphia-chromosome-positive acute lymphoblastic leukemia relapsed after myeloablative allogeneic hematopoietic stem cell transplantation treated successfully with imatinib and sequential donor lymphocyte infusions.	18696183
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	A 23-year-old man with Philadelphia-chromosome-positive (Ph(+)) acute lymphoblastic leukemia (ALL) underwent myeloablative allogeneic hematopoietic stem cell transplantation (allo-HSCT) from his HLA-identical brother in first hematological remission following induction chemotherapy which included imatinib.	18696183
Respiratory Syncytial Virus Infections, Hematological Disease, Communicable Diseases	Stem Cell Exhaustion	Here we report the spread of respiratory syncytial virus (RSV) infection among three patients, who were hospitalized in an adult hematopoetic stem cell transplantation (HSCT) unit because of hematologic diseases, and effects of RSV infection on post-transplant outcome.	18697436
B-Cell Lymphomas, Gastrointestinal mucositis	Stem Cell Exhaustion	Effect of the dose per body weight of conditioning chemotherapy on severity of mucositis and risk of relapse after autologous haematopoietic stem cell transplantation in relapsed diffuse large B cell lymphoma.	18699848
B-Cell Lymphomas, Chemosensitivity, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	High-dose chemotherapy and haematopoietic stem cell (HSC) transplantation is considered standard therapy in patients with chemosensitive relapsed diffuse large B cell lymphoma (DLBCL).	18699848
Chondrosarcoma	Stem Cell Exhaustion	A chondrogenic gene expression signature in mesenchymal stem cells is a classifier of conventional central chondrosarcoma.	18702172
Chondrogenic Neoplasm	Stem Cell Exhaustion	We hypothesized that a comparison between cartilaginous tumours and their possible physiological cells of origin, mesenchymal stem cells (MSCs), might have biological and clinical relevance.	18702172
Memory Loss	Stem Cell Exhaustion	As memory loss can occur through a deteriorated neurogenic capacity, we have studied the effects of Hcy on neural progenitor cells (NPCs) both in vitro and in vivo.	18703672
Arthritis, Psoriatic	Stem Cell Exhaustion	Normal levels and function of endothelial progenitor cells in patients with psoriatic arthritis.	18704428
Ischemia	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) are a population of bone marrow derived cells which have been attributed with the ability to migrate into areas of tissue ischemia and to posses reparative qualities.	18704428
Central neuroblastoma	Stem Cell Exhaustion	From 1993 to 1995, the Pediatric Oncology Group (POG) enrolled patients with high-risk neuroblastoma on three sequential, conjoined studies: a phase II induction window (9340), followed by intensive multiagent induction chemotherapy (9341), and subsequent myeloablative therapy with autologous stem cell rescue (9342).	18704922
Central neuroblastoma	Stem Cell Exhaustion	These studies were the first attempt by POG to use autologous stem cell transplantation for neuroblastoma treatment in a cooperative group setting.	18704922
Allogeneic Hematopoietic Stem Cell Transplantation, Central neuroblastoma	Stem Cell Exhaustion	[Treatment of stage IV neuroblastoma with allogeneic hematopoietic stem cell transplantation in children].	18706162
Central neuroblastoma	Stem Cell Exhaustion	A 7-year-old boy with stage IV neuroblastoma received allogenetic hematopoietic stem cell transplantation.	18706162
Central neuroblastoma	Stem Cell Exhaustion	Haploid HLA-matched allogeneic hematopoietic stem cell transplantation from parent donor was an alternative, safe and effective treatment for children with stage IV neuroblastoma.	18706162
Virus Diseases	Stem Cell Exhaustion	Clinical efficacy of prophylactic strategy of long-term low-dose acyclovir for Varicella-Zoster virus infection after allogeneic peripheral blood stem cell transplantation.	18707605
herpesvirus 3, human, Virus Diseases	Stem Cell Exhaustion	Varicella-Zoster virus infection (VZV) has a high incidence post-allogeneic peripheral blood stem cell transplant (PBSCT).	18707605
Neoplasms	Stem Cell Exhaustion	There is mounting evidence that SpCC is a monoclonal neoplasm originating from a stem cell giving rise to both components.	18712413
Pneumonia	Stem Cell Exhaustion	We report a case of severe parainfluenza (PIV) 3 pneumonia in a hematopoietic stem cell transplant recipient that was successfully treated with oral ribavirin and methylprednisolone.	18712461
Lupus Erythematosus	Stem Cell Exhaustion	High-dose chemotherapy without stem cell transplantation for refractory childhood systemic lupus erythematosus.	18714153
Lupus Erythematosus, Encephalitis, St. Louis	Stem Cell Exhaustion	Intensive chemotherapy followed by autologous hematopoietic stem cell transplantation (ASCT) is effective for refractory systemic lupus erythematosus (SLE).	18714153
Cessation of life, Cytogenetic Complete Response	Stem Cell Exhaustion	Expression of A-type lamins increases the risk of death from CRC because its presence gives rise to increased invasiveness and potentially a more stem cell-like phenotype.	18714339
Neoplasms	Stem Cell Exhaustion	We found that lamin A is expressed in colonic stem cells and that patients with A-type lamin-expressing tumours have significantly worse prognosis than patients with A-type lamin negative tumours (HR = 1.85, p = 0.005).	18714339
Polycythemia Vera	Stem Cell Exhaustion	Dasatinib inhibits progenitor cell proliferation from polycythaemia vera.	18717827
Toxic effect, Comorbidity, Multiple Myeloma	Stem Cell Exhaustion	Utility of comorbidity assessment in predicting transplantation-related toxicity following autologous hematopoietic stem cell transplantation for multiple myeloma.	18721767
Toxic effect	Stem Cell Exhaustion	Patients with coexisting medical problems may suffer increased toxicity and reduced quality of life after autologous hematopoietic stem cell transplantation (HSCT).	18721767
Graft-vs-Host Disease	Stem Cell Exhaustion	The use of allogeneic stem cells is associated with a less risk of relapse, but is also associated with the risk of GVHD.	18724296
Diabetes	Stem Cell Exhaustion	Establishing a human pancreatic stem cell line and transplanting induced pancreatic islets to reverse experimental diabetes in rats.	18726523
Multiple Myeloma	Stem Cell Exhaustion	Mobilization of peripheral blood stem cells in myeloma with either pegfilgrastim or filgrastim following chemotherapy.	18728024
Multiple Myeloma	Stem Cell Exhaustion	Quality and quantity of mobilized peripheral blood stem cells determine the safety of tandem autologous transplants in myeloma.	18728024
Primary Myelofibrosis	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation in myelofibrosis: the 20-year experience of the Gruppo Italiano Trapianto di Midollo Osseo (GITMO).	18728030
Primary Myelofibrosis	Stem Cell Exhaustion	Allogeneic stem cell transplantation is a potentially curative treatment for myelofibrosis, although its use is limited by a high rate of transplant-related mortality.	18728030
Primary Myelofibrosis	Stem Cell Exhaustion	In this study, we evaluated the outcome of patients with myelofibrosis who underwent allogeneic stem cell transplantation, and the impact of prognostic factors.	18728030
Transplant-Related Malignant Neoplasm	Stem Cell Exhaustion	In multivariate analysis, negative predictors of transplant-related mortality were year of stem cell transplantation before 1995, unrelated donor, and a long interval between diagnosis and transplantation.	18728030
Primary Myelofibrosis	Stem Cell Exhaustion	We conclude that the outcome of myelofibrosis patients who underwent allogeneic stem cell transplantation significantly improved after 1996 due to the reduction in transplant-related mortality.	18728030
Hepatobiliary Disorder	Stem Cell Exhaustion	Reduced mobilisation of hematopoietic stem cells after hepatic resection for malignant liver disease.	18752047
Liver damage	Stem Cell Exhaustion	Recent studies have demonstrated that hematopoietic stem cells (HSCs) can mobilize following liver resection, thus contributing to the repair of hepatic damage.	18752047
Lesion of liver	Stem Cell Exhaustion	It is probably in this context that a reason may be found for the different mobilisation of hematopoietic stem cells, depending on the nature of the hepatic lesion treated, that was encountered in this study.	18752047
Hypertrophic	Stem Cell Exhaustion	Human hypertrophic nonunion tissue contains mesenchymal progenitor cells with multilineage capacity in vitro.	18752274
Hypertrophic	Stem Cell Exhaustion	In this study, we hypothesized that the intervening tissue at the hypertrophic nonunion site (nonunion tissue) could serve as a reservoir of mesenchymal progenitor cells and investigated whether the cells derived from nonunion tissue had the capacity for multilineage mesenchymal differentiation.	18752274
Hypertrophic	Stem Cell Exhaustion	These results demonstrated for the first time that hypertrophic nonunion tissue contains multilineage mesenchymal progenitor cells.	18752274
Multiple Myeloma	Stem Cell Exhaustion	Combined bendamustine, prednisolone and thalidomide for refractory or relapsed multiple myeloma after autologous stem-cell transplantation or conventional chemotherapy: results of a Phase I clinical trial.	18752593
Cytomegalovirus Infections	Stem Cell Exhaustion	Quantification of DNA in plasma by an automated real-time PCR assay (cytomegalovirus PCR kit) for surveillance of active cytomegalovirus infection and guidance of preemptive therapy for allogeneic hematopoietic stem cell transplant recipients.	18753357
Cytomegalovirus Infections	Stem Cell Exhaustion	The performance of a plasma real-time PCR (cytomegalovirus [CMV] PCR kit; Abbott Diagnostics) was compared with that of the antigenemia assay for the surveillance of active CMV infection in 42 allogeneic hematopoietic stem cell transplantation (Allo-SCT) recipients.	18753357
Medulloblastoma	Stem Cell Exhaustion	Hedgehog (Hh) signalling controls cerebellar granule cell progenitor development and a subversion of this pathway leads to neoplastic transformation into medulloblastoma (MB).	18756266
Malignant tumor of colon, Specialty Type - cancer	Stem Cell Exhaustion	A stochastic model for cancer stem cell origin in metastatic colon cancer.	18757407
Malignant Neoplasms, Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	Human cancers have been found to include transformed stem cells that may drive cancer progression to metastasis.	18757407
Malignant tumor of colon, Neoplasms	Stem Cell Exhaustion	Here, we report that metastatic colon cancer contains clonally derived tumor cells with all of the critical properties expected of stem cells, including self-renewal and the ability to differentiate into mature colon cells.	18757407
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Karyotype analyses of parental and clonally derived tumor cells expressed many consistent (clonal) along with unique chromosomal aberrations, suggesting the presence of chromosomal instability in the cancer stem cells.	18757407
Specialty Type - cancer	Stem Cell Exhaustion	Thus, this new model for cancer origin and metastatic progression includes features of both the hierarchical model for cancerous stem cells and the stochastic model, driven by the observation of chromosomal instability.	18757407
Amyloidosis	Stem Cell Exhaustion	We prospectively studied the clinical usefulness of cyclic VAD (vincristine, doxorubicin and dexamethasone) in patients with primary systemic AL amyloidosis who were ineligible for high-dose melphalan with autologous stem cell support.	18758127
Graft-vs-Host Disease	Stem Cell Exhaustion	Acute Graft-Versus-Host Disease (aGVHD), mediated by CD4(+) and CD8(+) effector T cells, is a life-threatening complication in hematopoietic stem cell (HSC) transplantation.	18760679
Glioma	Stem Cell Exhaustion	In vitro, no differences in stem cell properties concerning self-renewal and multi-lineage differentiation have been found for CD133(+) cells isolated from gliomas of different grades.	18761091
Glioblastoma Multiforme Pathway, Neoplasms	Stem Cell Exhaustion	These findings indicate a solely quantitative correlation of glioma grade with the presence of neural CD133(+) cells within tumors supporting the concept of a CD133(+) stem cell dependent gliomagenesis.	18761091
Glioma, Specialty Type - cancer, Glioblastoma	Stem Cell Exhaustion	Presence of CD133(+) cancer stem cells has been demonstrated within glioblastoma multiforme (GBM), the most malignant phenotype of gliomas (WHO grade IV).	18761091
Cytopenia	Stem Cell Exhaustion	Fludarabine-based reduced-intensity (n=11) or nonmyelablative (n=16) conditioning and peripheral blood stem cell infusion from related (n=6) or unrelated (n=21) donors could be done in 27 patients during cytopenia.	18765552
pituitary dysfunction, Blindness, Secondary Neoplasm, Structure of suprasellar region	Stem Cell Exhaustion	Overgrowth persisted, but blindness and pituitary dysfunction resolved when the suprasellar tumor and CSF metastasis responded to cyclosporine-modulated systemic chemotherapy with intraventricular chemotherapy, consolidated with marrow-ablative chemotherapy and stem cell rescue of the bone marrow.	18766991
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Matched unrelated or matched sibling donors result in comparable survival after allogeneic stem-cell transplantation in elderly patients with acute myeloid leukemia: a report from the cooperative German Transplant Study Group.	18768435
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In patients with acute myeloid leukemia (AML), differential indications for matched sibling and unrelated hematopoietic stem-cell transplantation (HCT) are considered, and arbitrary age limits for HCT exist.	18768435
Pre-Eclampsia	Stem Cell Exhaustion	Compared with normal pregnancy, the number of endothelial progenitor cells was significantly lower, differentiation time from endothelial progenitor cell into outgrowing cell was longer, and the number of colonies after differentiation was smaller in preeclampsia (P< .001), respectively.	18771975
Pre-Eclampsia	Stem Cell Exhaustion	Increased senescence and reduced functional ability of fetal endothelial progenitor cells in pregnancies complicated by preeclampsia without intrauterine growth restriction.	18771975
Pre-Eclampsia	Stem Cell Exhaustion	The aim of this study was to investigate the number and functional ability of fetal endothelial progenitor cells in pregnancies complicated by preeclampsia without intrauterine growth restriction.	18771975
Pre-Eclampsia	Stem Cell Exhaustion	Fetal endothelial progenitor cells were isolated, and counted from 17 women with preeclampsia without intrauterine growth restricion and 30 normal women.	18771975
Pre-Eclampsia	Stem Cell Exhaustion	The number and functional ability of fetal endothelial progenitor cells from preeclampsia without intrauterine growth restriction are significantly decreased and they are more senescent compared with those of normal pregnancy.	18771975
Lymphoma, Follicular, B-Cell Lymphomas	Stem Cell Exhaustion	High-dose therapy and autologous stem cell transplantation for follicular lymphoma undergoing transformation to diffuse large B-cell lymphoma.	18774954
Precursor T-cell lymphoblastic lymphoma, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	A possible explanation for the simultaneous presentation of T-cell lymphoblastic lymphoma and myelodysplastic syndrome is that transformation occurs in pluripotent stem cells differentiating into myeloid and lymphoid cells.	18776765
Chickenpox	Stem Cell Exhaustion	After foscarnet therapy, she underwent stem cell transplantation without varicella reactivation.	18776818
Heart failure, Amyloidosis	Stem Cell Exhaustion	Patients with primary (AL) amyloidosis and heart failure have a very poor prognosis and cannot tolerate aggressive therapy, such as autologous stem cell transplantation and high-dose dexamethasone-based regimens.	18779964
Cessation of life, Adenocarcinoma of pancreas	Stem Cell Exhaustion	The stem cell-associated Hiwi gene in human adenocarcinoma of the pancreas: expression and risk of tumour-related death.	18781170
Malignant tumor of colon, Neoplasms	Stem Cell Exhaustion	Colon cancer cells have previously been demonstrated to contain a subpopulation of CD133+ tumour cells that have the ability to initiate tumour growth and are thus referred to as colon cancer-initiating cells or colon cancer stem cells (CSCs).	18781171
Infection, Communicable Diseases	Stem Cell Exhaustion	Epidemiology of invasive mold infections in allogeneic stem cell transplant recipients: biological risk factors for infection according to time after transplantation.	18781877
Infection	Stem Cell Exhaustion	Invasive mold infections (IMIs) are common in individuals who have undergone hematopoietic stem cell transplantation (HSCT).	18781877
Hantavirus Infections, Drug-induced	Stem Cell Exhaustion	Nineteen patients were diagnosed as having autoimmune-associated HPS, eight infection-associated, one drug-induced and one developed HPS after haematopoietic stem cell transplantation.	18782855
Hypertension, CTCAE	Stem Cell Exhaustion	Aging and hypertension are independent risk factors for reduced number of circulating endothelial progenitor cells.	18787520
Multiple Myeloma	Stem Cell Exhaustion	In patients with multiple myeloma the median overall survival is now approaching 5 years, following the introduction of autologous stem cell transplantation and targeted therapies.	18791685
Malignant Head and Neck Neoplasm	Stem Cell Exhaustion	Elevated levels of circulating endothelial progenitor cells in head and neck cancer patients.	18792958
Fungemia	Stem Cell Exhaustion	We identified three cases of C. tropicalis strains causing breakthrough fungemia in allogeneic stem cell recipients receiving caspofungin prophylaxis and treatment.	18794386
Antilymphocyte Serum	Stem Cell Exhaustion	Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS.	18797452
Antilymphocyte Serum, AMYOTROPHIC LATERAL SCLEROSIS 1	Stem Cell Exhaustion	In order to maintain muscle connections in a rat model of familial ALS (FALS), we performed intramuscular transplantation with human mesenchymal stem cells (hMSCs) used as "Trojan horses" to deliver growth factors to the terminals of motor neurons and to the skeletal muscles.	18797452
Hemolytic disorder	Stem Cell Exhaustion	It is a Coomb's negative rare hemolytic disorder characterized by non-malignant clonal expansion of haemopoietic stem cells due to acquired genetic mutations.	18798591
Congestive heart failure	Stem Cell Exhaustion	Circulating apoptotic progenitor cells in patients with congestive heart failure.	18800166
Primary central nervous system lymphoma	Stem Cell Exhaustion	High-dose therapy with autologous stem cell support after standard dose induction is a promising approach for therapy of primary central nervous system lymphoma (PCNSL).	18801020
Primary central nervous system lymphoma	Stem Cell Exhaustion	This investigation describes the data from stem cell mobilization and apheresis procedures after one or two cycles of HD-MTX for induction of PCNSL within the East German Study Group for Haematology and Oncology 053 trial.	18801020
Primary central nervous system lymphoma	Stem Cell Exhaustion	HD-MTX plus G-CSF is a powerful combination for stem cell mobilization in patients with PCNSL and permits safe conduction of time-condensed and dose-intense protocols with high-dose therapy followed by stem cell reinfusion after HD-MTX induction.	18801020
Primary central nervous system lymphoma	Stem Cell Exhaustion	Mobilization of hemopoietic stem cells with high-dose methotrexate plus granulocyte-colony-stimulating factor in patients with primary central nervous system lymphoma.	18801020
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Quantitative assessment of WT1 gene expression after allogeneic stem cell transplantation is a useful tool for monitoring minimal residual disease in acute myeloid leukemia.	18801058
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Quantification of WT1 in bone marrow samples may be useful as a marker of minimal residual disease (MRD) and may predict the relapse of AML after allogeneic hematopoietic stem cell transplant (HSCT).	18801058
Neoplasms	Stem Cell Exhaustion	Musashi 1, a marker of neural stem cells, was strongly positive in both the tumor body and the MT.	18802789
Central Nervous System, leukemia	Stem Cell Exhaustion	Central nervous system relapse of leukemia after allogeneic hematopoietic stem cell transplantation.	18804039
leukemia	Stem Cell Exhaustion	Little information is available regarding central nervous system (CNS) relapse of adult leukemia after allogeneic hematopoietic stem cell transplantation (HSCT).	18804039
Autoimmune cytopenia, Chronic graft-versus-host disease, Stable chronic Graft vs Host Disease	Stem Cell Exhaustion	Autoimmune cytopenias are a recognized complication of hematopoietic stem cell transplant (HSCT), and are considered to be a feature of chronic graft-versus-host disease (cGVHD).	18804040
Anemia	Stem Cell Exhaustion	HLA-matched sibling hematopoietic stem cell transplantation for fanconi anemia: comparison of irradiation and nonirradiation containing conditioning regimens.	18804044
Congenital heart disease, altretamine/cisplatin/cyclophosphamide protocol	Stem Cell Exhaustion	In pediatric congenital heart disease (CHD) patients, manipulation of resident progenitor cells may provide important new approaches to improving outcomes.	18805183
Cytomegalovirus Infections	Stem Cell Exhaustion	Results of a phase I/II British Society of Bone Marrow Transplantation study on PCR-based pre-emptive therapy with valganciclovir or ganciclovir for active CMV infection following alemtuzumab-based reduced intensity allogeneic stem cell transplantation.	18805583
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Berberine inhibits SDF-1-induced AML cells and leukemic stem cells migration via regulation of SDF-1 level in bone marrow stromal cells.	18805669
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In this study, we investigated the effects of berberine on the SDF-1-induced HL-60 cells, primary acute myeloid leukemia (AML) cells and leukemic stem cells (LSCs) migration.	18805669
Choroidal Neovascularization	Stem Cell Exhaustion	Circulating hematopoietic stem cells in patients with idiopathic choroidal neovascularization.	18806291
Age related macular degeneration, Choroidal Neovascularization, methyldopa	Stem Cell Exhaustion	In a prior study, the correlation was investigated between circulating hematopoietic stem cells (HSCs) and the activity or severity of choroidal neovascularization (CNV) in patients with age-related macular degeneration (AMD).	18806291
Multiple Myeloma	Stem Cell Exhaustion	Helper T cells (CD3 + /CD4 + ) within the autologous peripheral blood stem cell graft positively correlate with event free survival of multiple myeloma patients.	18806749
peripheral blood	Stem Cell Exhaustion	A successful stem cell harvest is a prerequisite for peripheral blood SCT.	18806833
Multiple Myeloma	Stem Cell Exhaustion	We investigated the number of CD34(+) cells mobilized, the number of leukaphereses needed and the expenses of treatment for 28 patients with multiple myeloma randomly assigned to receive either G-CSF alone or G-CSF+EPO for stem cell mobilization after chemotherapy with ifosfamide, epirubicin and etoposide.	18806833
Immunologic Deficiency Syndromes	Stem Cell Exhaustion	Long-term neurocognitive function of pediatric patients with severe combined immune deficiency (SCID): pre- and post-hematopoietic stem cell transplant (HSCT).	18807155
Autoimmune Diseases, Thrombocytopenic purpura, Glomerulonephritis, Steroid Refractory Graft Versus Host Disease	Stem Cell Exhaustion	We now report on 13 subjects after peripheral blood stem-cell transplantation receiving low-dose rituximab (50 mg/m2) for steroid-refractory cGvHD and autoimmune disorders (membranous glomerulonephritis and immune thrombocytopenic purpura).	18813113
Abnormality	Stem Cell Exhaustion	Trisomy 8 in an allogeneic stem cell transplant recipient representative of a donor-derived constitutional abnormality.	18819096
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We report a case of a 20-year-old woman with acute myelogenous leukemia associated with the 11q23/MLL translocation who underwent allogeneic hematopoietic stem cell transplantation (HSCT) from a healthy, unrelated 26-year-old female.	18819096
Ototoxicity	Stem Cell Exhaustion	We investigated the fate of human cord blood CD133+ hematopoietic stem cells (HSC) transplanted intravenously (IV) into irradiated nod-scid mice previously made deaf by ototoxic treatment with kanamycin and/ or intense noise, to verify whether HSC engraft the cochlea and contribute to inner ear restoration, in vivo.	18819255
Idiopathic pneumonia syndrome	Stem Cell Exhaustion	Lastly, hMPV has been linked with severe idiopathic pneumonia in recipients of hematopoietic stem cell transplants.	18820584
Toxic effect, PAFAH1B1 wt Allele	Stem Cell Exhaustion	Tipifarnib exerted selective in vitro toxicity against clonal MDS hematopoiesis at concentrations less than 10 nM the effect being more prominent in white cell progenitors.	18824842
IL13 gene	Stem Cell Exhaustion	[Significance of the examination of path between eosinophils in peripheral blood and marrow stem cells for evaluating the effect of hormone therapy in patients with allergic rhinitis].	18826114
IL13 gene	Stem Cell Exhaustion	By means of the detection of the numbers of CD34(+) cells and eosinophils (EOS), and the level of IL-5 in peripheral blood from normal controls and patients with allergic rhinitis pre- or post-treatment, the role of EOS-stem cells paths for treatment effect in allergic rhinitis (AR) was studied so as to find the convenient and quick indicators which could be used to evaluate the clinical therapeutic effect and adjust the methods of the hormone therapy.	18826114
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplant in 716 patients with multiple myeloma: low treatment-related mortality, feasibility of outpatient transplant, and effect of a multidisciplinary quality initiative.	18828972
Multiple Myeloma	Stem Cell Exhaustion	We report on the feasibility of outpatient transplant in 716 patients undergoing autologous stem cell transplant for multiple myeloma at Mayo Clinic's site in Rochester, MN, from January 1, 2000, through October 31, 2007.	18828972
Catheter infection, Communicable Diseases	Stem Cell Exhaustion	Patient diagnosis and history of previous catheter infection did not increase catheter infection risk, but patients undergoing stem cell transplantation had an increased infection risk.	18831907
Sepsis	Stem Cell Exhaustion	The increase of endothelial progenitor cells in the peripheral blood: a new parameter for detecting onset and severity of sepsis.	18831938
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We report the case of a 50-year-old patient who underwent an allogenic haematopoietic stem-cell transplantation for acute myeloid leukaemia.	18832921
Graft-vs-Host Disease	Stem Cell Exhaustion	Regulatory T cells (Treg) play a pivotal role in the control of graft-versus-host disease (GVHD) and might also influence the graft-versus-tumor effect after allogeneic stem cell transplantation.	18833007
Hematologic Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	One sample included breast cancer patients an average of five years following treatment; the second sample included patients with hematological malignancies which had been tested before and 100 days after stem cell transplantation.	18833503
Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Pretransplantation positron emission tomography scan is the main predictor of autologous stem cell transplantation outcome in aggressive B-cell non-Hodgkin lymphoma.	18833583
Lymphoma, Non-Hodgkin, Familial, Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Limited data exist about the role of second-line chemotherapy response assessed by positron emission tomography (PET) as a prognostic factor in patients with aggressive non-Hodgkin Lymphoma (NHL) who undergo autologous stem cell transplantation (ASCT).	18833583
Sepsis	Stem Cell Exhaustion	Severe sepsis in autologous stem cell transplant recipients: microbiological aetiology, risk factors and outcome.	18836947
Malignant tumor of cervix, Stem Cell Factor	Stem Cell Exhaustion	[The plasma levels and diagnostic utility of stem cell factor (SCF) and macrophage-colony stimulating factor (M-CSF) in cervical cancer patients].	18839612
Leukemia, Mast-Cell	Stem Cell Exhaustion	[Effective PAD (bortezomib, doxorubicin, dexamethasone) treatment of a patient with plasma cell leukaemia that has developed after autologous stem cell transplantation].	18842514
Leukemia, Mast-Cell	Stem Cell Exhaustion	The authors present a case of a patient with non-secretory multiple myeloma who had developed plasma cell leukaemia after peripheral stem cell transplantation.	18842514
Hepatitis B	Stem Cell Exhaustion	[The effect of hepatitis B virus infection on the outcome of hematopoietic stem cell transplantation].	18844000
Hepatitis B, Communicable Diseases	Stem Cell Exhaustion	To evaluate the effect of hepatitis B virus (HBV) infection on the outcome of hematopoietic stem cell transplantation (HSCT).	18844000
Thrombocytosis, Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Zap-70 positive chronic lymphocytic leukemia co-existing with Jak 2 V671F positive essential thrombocythemia: a common defective stem cell?	18849073
Chronic myeloproliferative disorder	Stem Cell Exhaustion	ET is a myeloproliferative stem cell disease.	18849073
Type II Mucolipidosis, Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	The occurrence of a less mature CLL in patients with a pluripotential stem cell disease raises the possibility that an initial "trigger hit" occurred in a pre-Jak 2 common early progenitor in these patients.	18849073
Malignant neoplasm of stomach	Stem Cell Exhaustion	Mesenchymal stem cell-like cells derived from human gastric cancer tissues.	18849111
Hematologic Neoplasms	Stem Cell Exhaustion	Sixty-nine patients with high-risk hematologic malignancies received DLI following fludarabine, CY and alemtuzumab with infusion of stem cells from a matched sibling (52) or partially matched family member donor (17).	18850014
Multiple Myeloma	Stem Cell Exhaustion	We compared three year-of-admission groups (1990-1995, 1996-2001, and 2002-2006) that matched changes in myeloma treatment (chemotherapy only, stem cell transplantation, and new molecules, respectively).	18853139
Multiple Myeloma	Stem Cell Exhaustion	By using an alkylator-free consolidation and reserving stem cell transplantation until the time of relapse, we hope that these treatment strategies will further prolong the survival of patients with myeloma.	18854289
yttrium-90-ibritumomab tiuxetan	Stem Cell Exhaustion	High-dose yttrium-90-ibritumomab tiuxetan with tandem stem-cell reinfusion: an outpatient preparative regimen for autologous hematopoietic cell transplantation.	18854569
Toxic effect	Stem Cell Exhaustion	To minimize hematologic toxicity, stem cells were reinfused at days 7 and 14 after (90)Y-ibritumomab tiuxetan.	18854569
Amyloidosis	Stem Cell Exhaustion	After chemotherapies, such as high-dose melphalan with autologous stem cell support, 20 of 31 patients with AL amyloidosis achieved complete hematological remission.	18854629
Liver carcinoma, Specialty Type - cancer, Hollings Cancer Center	Stem Cell Exhaustion	However, the effect of HNF4alpha on cancer stem cells (CSCs) and the treatment of hepatocellular carcinoma (HCC) with HNF4alpha have not been reported.	18925631
Specialty Type - cancer, Hollings Cancer Center	Stem Cell Exhaustion	Our results demonstrated that forced re-expression of HNF4alpha induced the differentiation of hepatoma cells into hepatocytes, dramatically decreased "stemness" gene expression and the percentage of CD133(+) and CD90(+) cells, which are considered as cancer stem cells in HCC.	18925631
Retinal Diseases	Stem Cell Exhaustion	Healthy Retinal Pigment Epithelium (RPE) cells are required for proper visual function and the phenomenon of RPE derivation from Human Embryonic Stem Cells (HESC) holds great potential for the treatment of retinal diseases.	18926821
Hematopoietic Neoplasms, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukemia (AML) is a neoplasm of hematopoietic stem cells with partial or complete loss of the ability to differentiate but with preserved proliferation capacity.	18927328
Virus Diseases	Stem Cell Exhaustion	This study was purposed to investigate immune reconstitution at 12 months after allogeneic peripheral blood stem cell transplantation (all-PBSCT) and its relation with the influencing factors such as age, HLA compatibility, graft versus host disease and viral infection.	18928611
Coronary Arteriosclerosis	Stem Cell Exhaustion	Osteocalcin expression by circulating endothelial progenitor cells in patients with coronary atherosclerosis.	18929243
Coronary Arteriosclerosis	Stem Cell Exhaustion	This study was designed to test whether patients with coronary atherosclerosis have increases in circulating endothelial progenitor cells (EPCs) expressing an osteogenic phenotype.	18929243
Vascular System Injuries, Calcinosis	Stem Cell Exhaustion	Endothelial progenitor cells contribute to vascular repair, but repair of vascular injury may result in calcification.	18929243
Pleural Effusion, Malignant	Stem Cell Exhaustion	[Treatment of malignant effusions with the injection of dendritic cells derived from autologous peripheral CD34+ stem cells].	18931710
Pleural Effusion, Malignant	Stem Cell Exhaustion	Twenty-three patients with 26 malignant effusions received chemotherapy and granulocyte colony-stimulating factor (G-CSF) or G-CSF alone to mobilize peripheral blood hematopoietic stem cells.	18931710
Tumor necrosis	Stem Cell Exhaustion	CD34+ stem cells were induced to differentiate into DCs by cytokines interleukin 4 (IL-4), granulocyte-macrophage colony stimulating factor (GM-CSF), and tumor necrosis factor-alpha (TNF-alpha).	18931710
Hepatitis B, REG1CP gene	Stem Cell Exhaustion	Hepatitis B virus (HBV)-reverse seroconversion (RS) following allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a frequent late-onset complication in recipients with previous HBV infection.	18940676
Lymphoma	Stem Cell Exhaustion	Elevated ferritin is associated with relapse after autologous hematopoietic stem cell transplantation for lymphoma.	18940678
Pregnancy Complications, Infectious	Stem Cell Exhaustion	Elevated serum ferritin is associated with reduced survival following allogeneic transplantation and an increased risk of toxic and infectious complications after autologous hematopoietic stem cell transplantation (ASCT).	18940678
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	Collection of an adequate number of hematopoietic stem cells can be difficult in patients with relapsed or refractory Hodgkin lymphoma (HL) who are candidates for autologous stem cell transplantation (ASCT).	18940680
Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Plerixafor (AMD3100), an inhibitor of the interaction between stromal cell-derived factor 1 (SDF-1) and its receptor CXCR4, is an effective hematopoietic stem cell mobilization agent in patients with multiple myeloma and non-Hodgkin lymphoma (NHL).	18940680
LIPC gene	Stem Cell Exhaustion	This study was undertaken to investigate the efficacy and safety of hematopoietic stem cell mobilization with plerixafor in patients with HL.	18940680
Hodgkin Disease	Stem Cell Exhaustion	A phase II study of plerixafor (AMD3100) plus G-CSF for autologous hematopoietic progenitor cell mobilization in patients with Hodgkin lymphoma.	18940680
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Autologous stem cell transplantation with PCR-negative graft would be associated with a favorable outcome in core-binding factor acute myeloid leukemia.	18940681
Core binding factor acute myeloid leukemia	Stem Cell Exhaustion	To evaluate the effectiveness of autologous stem cell transplantation (ASCT) with a PCR-negative graft we analyzed a series of consecutive CBF-AML patients.	18940681
Renal dysfunction	Stem Cell Exhaustion	Successful outcome after nonmyeloablative allogeneic hematopoietic stem cell transplantation in patients with renal dysfunction.	18940687
GDC Comorbidity Terminology	Stem Cell Exhaustion	Nonmyeloablative allogeneic hematopoietic stem cell transplantation (HSCT) is a transplantation approach that enables patients with comorbid conditions to undergo allogeneic HSCT.	18940687
Multiple Myeloma	Stem Cell Exhaustion	Despite of the introduction of novel treatment modalities for multiple myeloma, high-dose chemotherapy with hematopoietic stem-cell rescue is still considered the standard of care for eligible patients <65 years of age.	18941780
malignant myeloma, Aggressive behavior, Neoplasms	Stem Cell Exhaustion	Whether high contamination of grafts with plasma cells might reflect residual in vivo tumor mass prior to stem cell transplantation and a generally more aggressive behavior of malignant myeloma cells in these patients, or whether reinfused plasma cells contribute to an unfavorable course of disease remains to be determined.	18941780
Multiple Myeloma	Stem Cell Exhaustion	Contamination of autologous peripheral blood progenitor cell grafts predicts overall survival after high-dose chemotherapy in multiple myeloma.	18941780
Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	She then underwent autologous peripheral blood haematopoietic stem cell transplantation and remained disease-free two years after the diagnosis.	18946602
Graft-vs-Host Disease	Stem Cell Exhaustion	Combined with data showing evident graft-versus-leukemia effects without graft-versus-host disease in a cord blood stem cell transplanted pDCL case, leukemic cells in pDCL may act as potent antigen presenting cells in vivo, too.	18948686
Multiple Myeloma	Stem Cell Exhaustion	Infusion of haplo-identical killer immunoglobulin-like receptor ligand mismatched NK cells for relapsed myeloma in the setting of autologous stem cell transplantation.	18950462
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We investigated the feasibility of transfusing haplo-identical, T-cell depleted, KIR-ligand mismatched NK cells, after conditioning therapy with melphalan and fludarabine, to patients with advanced multiple myeloma (MM) followed by delayed rescue with autologous stem cells.	18950462
Graft-vs-Host Disease, Failure	Stem Cell Exhaustion	No graft-versus-host disease or failure of autologous stem cells to engraft was observed.	18950462
Cockayne Syndrome	Stem Cell Exhaustion	These results suggest that the robust statistical association between dental and mental pathology may be related to common underlying pathophysiological mechanisms such as a progeroid or stem cell deficiency process in clinical addiction.	18953330
Night time, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria is a rare acquired nocturnal disorder of the hematopoietic stem cells.	18954293
Fracture	Stem Cell Exhaustion	The effect of autologous serum obtained after fracture on the proliferation and osteogenic differentiation of mesenchymal stem cells.	18954549
Fracture	Stem Cell Exhaustion	The purpose of this study was to investigate the potential of Mesenchymal Stem Cells (MSCs) obtained from patients suffering from fractures to proliferate and differentiate towards osteogenic lineage with the use of autologous serum.	18954549
Multiple Myeloma	Stem Cell Exhaustion	Poor outcomes for IgD multiple myeloma patients following high-dose melphalan and autologous stem cell transplantation: a single center experience.	18955788
Neoplasms	Stem Cell Exhaustion	The presented case is the youngest and the occurrence of MINST in a 14-month-old girl may support the hypothesis of multipotent mesenchymal stem cell origin; however, the tumors which arise from multipotent mesenchymal stem cells may be seen in later stages of life.	18972118
Communicable Diseases	Stem Cell Exhaustion	Carbapenem-resistant K. pneumoniae infection was independently associated with recent organ or stem-cell transplantation (P=.008), receipt of mechanical ventilation (P=.04), longer length of stay before infection (P=.01), and exposure to cephalosporins (P=.02) and carbapenems (P<.001).	18973455
Myocardial necrosis, Vascular System Injuries	Stem Cell Exhaustion	Local vessel injury following percutaneous coronary intervention does not promote early mobilisation of endothelial progenitor cells in the absence of myocardial necrosis.	18977801
Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy with autologous stem cell transplantation for multiple myeloma: what predicts the outcome?	18978818
Multiple Myeloma	Stem Cell Exhaustion	We analyzed the results of 108 patients (78 males and 30 females) with multiple myeloma who underwent autologous stem cell transplantation (ASCT).	18978818
Chronic myeloproliferative disorder, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myelogenous leukemia (CML) is a malignant myeloproliferative disease developing out of pluripotent hematopoietic stem cells that contain the fusion Bcr-Abl gene.	18979557
Neoplasms	Stem Cell Exhaustion	A single CD44(+) cell from a tumor could form a sphere in vitro which has characteristic stem cell properties and was able to generate a xenograft tumor resembling the properties of the primary tumor.	18980968
Colorectal Carcinoma	Stem Cell Exhaustion	CD44 is of functional importance for colorectal cancer stem cells.	18980968
Colorectal Carcinoma	Stem Cell Exhaustion	Both CD44 and CD133 were reported as putative markers for isolating colorectal cancer stem cells (CSC).	18980968
Endothelial Progenitor Cells, Old age	Stem Cell Exhaustion	Increased vascular senescence and impaired endothelial progenitor cell function mediated by mutation of circadian gene Per2.	18981300
Endothelial dysfunction, Old age	Stem Cell Exhaustion	We hypothesize that endothelial dysfunction in Per2 mutant (Per2(m/m)) mice is mediated in part by increased vascular senescence and impaired endothelial progenitor cell (EPC) function.	18981300
Scleroderma	Stem Cell Exhaustion	Transcriptional regulation of Bim by FOXO3a and Akt mediates scleroderma serum-induced apoptosis in endothelial progenitor cells.	18981303
Vascular Diseases	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) contribute to vascular regeneration/repair and thus may protect against scleroderma vasculopathy.	18981303
Hematologic Neoplasms, Mycoses	Stem Cell Exhaustion	This retrospective single-center study analyzed incidence, treatment and outcome of invasive fungal infections in 1,095 patients with hematological malignancies receiving either cytoreductive chemotherapy or autologous or allogeneic hematopoietic stem cell transplantation at our institution between 1995 and 2004.	18982251
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Along with chemotherapy, dasatinib should be considered in these patients particularly if they cannot undergo allogeneic stem cell transplantation for this poor prognostic AML.	18986703
Lymphoproliferative Disorders	Stem Cell Exhaustion	Stem cell factor and high-dose twice daily filgrastim is an effective strategy for peripheral blood stem cell mobilization in patients with indolent lymphoproliferative disorders previously treated with fludarabine: results of a Phase II study with an historical comparator.	18987661
RAPH1 gene, Lymphoproliferative Disorders	Stem Cell Exhaustion	Fludarabine exposure leads to impaired peripheral blood stem cell (PBSC) mobilization in indolent lymphoproliferative disorders (LPD).	18987661
Primary Myelofibrosis, PMF Regimen	Stem Cell Exhaustion	Therapeutic decision-making in primary myelofibrosis (PMF) is becoming more challenging because of the increasing use of allogeneic stem cell transplantation and new investigational drugs.	18988864
Ischemia	Stem Cell Exhaustion	The prostacyclin analogue iloprost increases circulating endothelial progenitor cells in patients with critical limb ischemia.	18989532
CLU protein, human, Ischemia	Stem Cell Exhaustion	Patients with critical limb ischemia (CLI) have low levels of endothelial progenitor cells (EPC).	18989532
Childhood Breast Carcinoma	Stem Cell Exhaustion	Differential association of alterations in FANCC and PTCH1 with that of PHF2, XPA and two breast cancer susceptibility genes (BRCA1/BRCA2) in the two age groups suggests differences in their molecular pathogenesis and dysregulation of multiple DNA repair pathways as well as hedgehog dependent stem cell renewal pathway.	18990233
Alzheimers Disease	Stem Cell Exhaustion	Decreased plasma and cerebrospinal fluid levels of stem cell factor in patients with early Alzheimer's disease.	18997298
Stem Cell Factor	Stem Cell Exhaustion	Stem cell factor (SCF) is a hematopoietic growth factor (HGF) that promotes neuroprotective effects and supports neurogenesis in the brain.	18997298
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Whether this tumor arises from a single cancer stem cell with subsequent differentiation or represents collision of the progeny of two separate cancer stem cells is a matter of controversy.	18997737
Multiple Myeloma	Stem Cell Exhaustion	Comparison of high-dose CY and growth factor with growth factor alone for mobilization of stem cells for transplantation in patients with multiple myeloma.	18997825
Graft-vs-Host Disease, Lymphoma	Stem Cell Exhaustion	Improved survival in lymphoma patients receiving sirolimus for graft-versus-host disease prophylaxis after allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning.	19001324
Graft-vs-Host Disease	Stem Cell Exhaustion	Sirolimus, an mTOR inhibitor, also has activity in the treatment and prophylaxis of graft-versus-host disease (GVHD) after allogeneic hematopoietic stem-cell transplantation (HSCT).	19001324
Graft-vs-Host Disease, Acute GVH disease, Malignant Neoplasms	Stem Cell Exhaustion	Morbidity from acute graft-versus-host disease (GVHD) limits the success of allogeneic hematopoietic stem-cell transplantation (HSCT) to treat malignancy.	19001329
Merkel cell carcinoma	Stem Cell Exhaustion	Co-expression of KIT receptor and its ligand stem cell factor in Merkel cell carcinoma.	19001805
Stem Cell Factor	Stem Cell Exhaustion	We investigated the co-expression of KIT and its ligand stem cell factor (SCF) in MCC.	19001805
Acute myocardial infarction	Stem Cell Exhaustion	Combined intracoronary and intramyocardial administration might improve outcomes for bone-marrow-derived stem cell therapy for acute myocardial infarction (AMI).	19002124
Myocardial Infarction	Stem Cell Exhaustion	Combined cardiac stem cell delivery induces a moderate but significant improvement in myocardial infarct size and left ventricular function.	19002124
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Combined delivery approach of bone marrow mononuclear stem cells early and late after myocardial infarction: the MYSTAR prospective, randomized study.	19002124
JAK2 NP_004963.1:p.V617F, Polycythemia Vera	Stem Cell Exhaustion	Polycythemia vera (PV) is a clonal hematopoietic stem cell disease characterized by a trilinear accumulation of blood cells that has been recently associated with a JAK2V617F point mutation.	19004005
Polycythemia Vera	Stem Cell Exhaustion	Imbalance of DNA-dependent protein kinase subunits in polycythemia vera peripheral blood stem cells.	19004005
Malignant Neoplasms	Stem Cell Exhaustion	Early lymphocyte recovery (ELR) after autologous peripheral hematopoietic stem cell transplantation (ASCT) is an independent predictor for survival in patients with hematological and non-hematological cancers.	19006229
Cessation of life, Comorbidity	Stem Cell Exhaustion	At the time of analysis, 22 patients were still awaiting SCT, 8 were delayed because they required additional courses of treatment, and 32 were excluded because of death (34.4%), poor stem cell mobilization (21.9%), patient refusal (15.6%), relapse/progression (9.4%), comorbidity (6.3%), or absence of a donor (6.3%).	19010206
Cessation of life	Stem Cell Exhaustion	SCT was not performed in 22% of transplant candidates, mainly due to death, insufficient stem cell mobilization, patient refusal, or disease progression/relapse.	19010206
Adenoma, Colorectal Carcinoma, Malignant tumor of colon	Stem Cell Exhaustion	Age-related increase in colorectal cancer stem cells in macroscopically normal mucosa of patients with adenomas: a risk factor for colon cancer.	19010307
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	It is becoming increasingly evident that cancer stem cells play a vital role in development and progression of cancers and relapse following chemotherapy.	19010307
Aortic Valve Stenosis	Stem Cell Exhaustion	Reduced number and function of endothelial progenitor cells in patients with aortic valve stenosis: a novel concept for valvular endothelial cell repair.	19010796
Arteriovenous graft stenosis	Stem Cell Exhaustion	This study investigated whether degenerative AV stenosis (AS) is associated with the presence of valvular endothelial senescence and a reduction in the number and function of endothelial progenitor cells (EPCs).	19010796
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Nuclear factor-kappaB (NF-kappaB) is constitutively expressed in many acute myelogenous leukemia (AML) cells and AML stem cells.	19010875
Anaplastic Oligodendroglioma, Acute lymphocytic leukemia	Stem Cell Exhaustion	Anaplastic oligodendroglioma after childhood acute lymphoblastic leukemia: chemotherapy and autologous peripheral blood stem cell transplantation.	19011476
Anaplastic Oligodendroglioma, BCR gene	Stem Cell Exhaustion	High-dose chemotherapy with stem cell rescue seems to be potentially effective for multiple recurrent anaplastic oligodendroglioma occurring after childhood ALL.	19011476
Amyotrophic Lateral Sclerosis	Stem Cell Exhaustion	Treatment of amyotrophic lateral sclerosis patients by autologous bone marrow-derived hematopoietic stem cell transplantation: a 1-year follow-up.	19012065
Neurodegenerative Disorders	Stem Cell Exhaustion	However, over the past few years stem cell research has expanded greatly as a tool for developing potential new therapies for treating incurable neurodegenerative diseases.	19012065
Electrocardiogram: myocardial infarction (finding), Infectious Lung Disorder	Stem Cell Exhaustion	Three patients died 1.5, 2 and 9 months, respectively, after stem cell therapy as a result of lung infection and myocardial infarction (MI).	19012065
Antilymphocyte Serum	Stem Cell Exhaustion	These results show that stem cell therapy is a safe, effective and promising treatment for ALS patients.	19012065
Amyotrophic Lateral Sclerosis, Antilymphocyte Serum	Stem Cell Exhaustion	Thirteen patients with sporadic amyotrophic lateral sclerosis (SALS) were included in this study, and bone marrow (BM)-derived hematopoietic progenitor stem cells were used.	19012065
Antilymphocyte Serum	Stem Cell Exhaustion	Our aim was to put the stem cells into the end of the brain stem and at the beginning of the spinal cord because the blood-brain barrier is intact in ALS and this region was the most affected part in our patients.	19012065
Graft-vs-Host Disease	Stem Cell Exhaustion	To determine the natural history of and guidelines for the surgical management of severe acute gastrointestinal (GI) graft-vs-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT).	19015460
Renal glomerular disease, Cutis Laxa, Pulmonary hemorrhage	Stem Cell Exhaustion	Generalized cutis laxa and fibrillar glomerulopathy resulting from IgG Deposition in IgG-lambda Monoclonal Gammopathy: pulmonary hemorrhage during stem cell mobilization and complete hematological response with bortezomib and dexamethasone therapy.	19018863
Pulmonary hemorrhage	Stem Cell Exhaustion	A peripheral blood autologous stem cell transplant was planned, but the procedure was complicated by severe pulmonary hemorrhage during stem cells mobilization with granulocyte colony-stimulating factor (G-CSF).	19018863
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	FCGR3A-158V/F polymorphism may correlate with the levels of immunoglobulin in patients with non-Hodgkin's lymphoma after rituximab treatment as an adjuvant to autologous stem cell transplantation.	19018870
Hypogammaglobulinemia	Stem Cell Exhaustion	Recent studies have indicated that patients who receive stem cell transplantation (SCT) and rituximab demonstrate an increased risk of developing hypogammaglobulinemia.	19018870
Electrocardiogram: myocardial infarction (finding), Diabetes Mellitus	Stem Cell Exhaustion	Diabetes mellitus impairs CD133+ progenitor cell function after myocardial infarction.	19019194
Ischemic	Stem Cell Exhaustion	Circulating progenitor cells (PC) can positively influence the healing of ischaemic myocardium.	19019194
Mantle cell lymphoma, Specialty Type - cancer, leukemia	Stem Cell Exhaustion	Ki67 and PIM1 expression predict outcome in mantle cell lymphoma treated with high dose therapy, stem cell transplantation and rituximab: a Cancer and Leukemia Group B 59909 correlative science study.	19021050
Medial collateral ligament, Specialty Type - cancer, leukemia	Stem Cell Exhaustion	We assessed Ki67 and PIM1 (a cell cycle-related gene upregulated in blastoid MCL) expression by immunohistochemistry in a phase II study Cancer and Leukemia Group B 59909 of aggressive chemotherapy and rituximab followed by autologous stem cell transplantation plus rituximab in untreated MCL patients <70 years of age.	19021050
Comorbidity, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Comorbidity predicts survival in myelodysplastic syndromes or secondary acute myeloid leukaemia after allogeneic stem cell transplantation.	19021720
Comorbidity, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Recent data suggest that, among other factors, comorbidity may be an important prognostic variable in patients with myelodysplastic syndromes (MDS) who are eligible for haematopoietic stem cell transplantation (SCT).	19021720
Graft-vs-Host Disease	Stem Cell Exhaustion	Clinical scale expanded adult pluripotent stem cells prevent graft-versus-host disease.	19022422
Acute GVH disease	Stem Cell Exhaustion	These data show that in vitro expanded adult stem cells can efficiently control an allo-reactive response associated with acute GVHD, that they are immuno-privileged and present strong immunosuppressive properties.	19022422
Bronchomalacia	Stem Cell Exhaustion	We removed cells and MHC antigens from a human donor trachea, which was then readily colonised by epithelial cells and mesenchymal stem-cell-derived chondrocytes that had been cultured from cells taken from the recipient (a 30-year old woman with end-stage bronchomalacia).	19022496
Ischemic stroke	Stem Cell Exhaustion	Use of bone marrow mesenchymal (stromal) stem cells in experimental ischemic stroke in rats.	19024019
Cerebral Infarction	Stem Cell Exhaustion	The effects of human mesenchymal stem cells on neurological functions and behavioral reactions of animals and on damaged brain tissue were studied on the model of focal cerebral ischemia in rats.	19024019
Liver carcinoma, Secondary malignant neoplasm of liver, Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cell marker expression in hepatocellular carcinoma and liver metastases is not sufficient as single prognostic parameter.	19026485
Liver carcinoma, Specialty Type - cancer, Colorectal Carcinoma Metastatic in the Liver	Stem Cell Exhaustion	We profiled suggested cancer stem cell markers in tissue specimens of hepatocellular carcinoma and colorectal carcinoma liver metastases.	19026485
Specialty Type - cancer	Stem Cell Exhaustion	About 1% of cells co-expressed cancer stem cell antigens, but there was no correlation between the amount of CD133(+), CD133(+)/CD44(+) or CD133(+)/CD24(-) cells and the patients' clinical-pathological status or with the cancer stem cell marker-positive cells localization.	19026485
Specialty Type - cancer	Stem Cell Exhaustion	Recent findings suggest that the presence of cancer stem cells could be linked with patients' survival.	19026485
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Autologous stem-cell transplantation as first-line therapy in peripheral T-cell lymphomas: results of a prospective multicenter study.	19029417
Specialty Type - cancer	Stem Cell Exhaustion	Ancestral trees for modeling stem cell lineages genetically rather than functionally: understanding mutation accumulation and distinguishing the restrictive cancer stem cell propagation theory and the unrestricted cell propagation theory of human tumorigenesis.	19029621
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells either could be rare or common in tumors, constituting the major distinction between the two fundamentally opposed theoretical models of tumor progression: A newer and restrictive stem cell propagation model, in which the stem cells are a small and special minority of the tumor cells, and a standard older model, an unrestricted cell proliferation theory, in which many or most tumor cells are capable of indefinite generations of cell division.	19029621
Malignant Neoplasms	Stem Cell Exhaustion	The simple concept that cancers arise from the transformation of a normal stem cell, the stem cell origination theory, is sometimes superficially and confusingly referred to as "the stem cell theory".	19029621
Neoplasms	Stem Cell Exhaustion	Stem cells of tumors are difficult to quantitate using functional assays, and the validity of the most common assays is seriously questioned.	19029621
Neoplasms	Stem Cell Exhaustion	Alternative approaches to studying tumor stem cells should be explored.	19029621
Graft-vs-Host Disease	Stem Cell Exhaustion	Increasing recipient age is a well-known risk factor for graft-versus-host disease (GVHD) and treatment-related mortality (TRM) and has a negative impact on allogeneic hematopoietic stem cell transplantation.	19030858
Multiple Myeloma	Stem Cell Exhaustion	[Outcome of bortezomib plus chemotherapy with or without stem cell transplantation for treatment of multiple myeloma].	19031743
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	To investigate the efficacy and adverse reaction of bortezomib plus chemotherapy with or without stem cell transplantation (SCT) for treatment of multiple myeloma (MM).	19031743
melanoma, Neoplasms, Stem Cell Factor	Stem Cell Exhaustion	Expression of stem cell factor (SCF) in melanoma cells as well as stromal cells suggests SCF/KIT autocrine and paracrine activation in these tumors.	19035443
Chronic disease	Stem Cell Exhaustion	Instructively, this theory provides a bridge at the stem cell level, linking most chronic disorders.	19035844
Medial collateral ligament, Toxic effect	Stem Cell Exhaustion	In conclusion, high-dose Ara-C and BEAM with stem cell rescue in newly diagnosed MCL patients responsive to R-CHOP is a manageable treatment with respect to toxicity.	19036081
Radiation-Recall Dermatitis	Stem Cell Exhaustion	We describe a 42-year-old female, who developed radiation recall dermatitis following an allogeneic stem cell transplant from an unrelated donor (MUD-PBSCT).	19036906
Neutropenia	Stem Cell Exhaustion	Use of micafungin versus fluconazole for antifungal prophylaxis in neutropenic patients receiving hematopoietic stem cell transplantation.	19039629
Hemorrhagic cystitis	Stem Cell Exhaustion	Quantification of BK polyoma viruria in Japanese children and adults with hemorrhagic cystitis complicating stem cell transplantation.	19040286
CLTC gene, Hemorrhagic cystitis	Stem Cell Exhaustion	Polyoma BK virus (BKV) is frequently found in the urine of stem cell transplantation (SCT) patients with hemorrhagic cystitis (HC), but also occurs in SCT patients without HC.	19040286
Acute lymphocytic leukemia	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation in adult acute lymphocytic leukemia: impact of donor source on survival.	19041062
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	We studied the relative impact of donor source on outcomes following myeloablative hematopoietic stem cell transplantation (HSCT) for adult patients with acute lymphocytic leukemia (ALL).	19041062
BCR gene	Stem Cell Exhaustion	When compared with URD:M, OS with UCB was better (RR 0.3, 95% CI, 0.1-0.7, P = .01), supporting the use of UCB as an alternative stem cell source for adults with ALL.	19041062
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The aim of this randomized phase II trial was to determine the safety and efficacy of a combination of ATO, melphalan, and AA as preparative regimen in 48 patients undergoing autologous hematopoietic stem cell transplantation (ASCT) for multiple myeloma (MM).	19041063
Malignant Neoplasms	Stem Cell Exhaustion	One hundred fifty-eight patients who consecutively underwent autologous stem cell transplantation for malignancy were included in the study.	19041066
Have Been Vomiting, Nausea	Stem Cell Exhaustion	The lollipop with strawberry aroma may be promising in reduction of infusion-related nausea and vomiting during the infusion of cryopreserved peripheral blood stem cells.	19041066
Have Been Vomiting, Nausea	Stem Cell Exhaustion	Nausea and vomiting during the infusion of cryopreserved peripheral blood stem cells (PBSC) are common.	19041066
Bacteremia, Allogeneic Hematopoietic Stem Cell Transplantation	Stem Cell Exhaustion	Risk factors for late Staphylococcus aureus bacteremia after allogeneic hematopoietic stem cell transplantation: a single-institution, nested case-controlled study.	19041067
Hematologic Neoplasms, Pneumonia, Communicable Diseases	Stem Cell Exhaustion	Cytomegalovirus (CMV) pneumonia is a life-threatening infection in patients with haematological malignancies (HMs) or in haematopoietic stem cell transplant (HSCT) recipients.	19046167
Atherosclerosis	Stem Cell Exhaustion	To elucidate the discrepancy between HGF and VEGF, we compared the effects of HGF and VEGF on endothelial progenitor cells under angiotensin II stimulation, which is a well-known risk factor for atherosclerosis.	19047582
Kidney Failure	Stem Cell Exhaustion	[Renal insufficiency after allogeneic stem cell transplantation in children].	19047783
Kidney Failure	Stem Cell Exhaustion	We retrospectively evaluated the incidence of renal insufficiency (RI) and risk factors involved in RI in 27 pediatric cases that underwent their first hematopoietic stem cell transplantation (HSCT) in our hospital.	19047783
PMF Regimen	Stem Cell Exhaustion	Curative therapy in PMF is currently possible only with allogeneic haematopoietic stem cell transplantation which is, unfortunately, associated with relatively high risks of mortality and morbidity which undermine its broad applications.	19052692
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Outcome of high-dose cytarabine-based induction therapy followed by hematopoietic stem cell transplantation in acute myeloid leukemia: influence of karyotype.	19052975
Polycythemia Vera	Stem Cell Exhaustion	Polycythemia vera (PV) is an uncommon clonal disorder of stem cells.	19055858
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In this context, the authors compared the chemokine receptor expression for T cells derived from healthy individuals and acute myelogenous leukemia patients with therapy-induced cytopenia after conventional chemotherapy or allogeneic stem cell transplantation.	19055860
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Results from the stem cells in myocardial infarction (STEMMI) trial.	19056135
Ototoxicity	Stem Cell Exhaustion	Because of limited response duration and considerable hematotoxicity, future investigations should focus on a multimodal approach with additional chemotherapy and preferably autologous stem cell support.	19060176
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Posttransplant lymphoproliferative disease (PTLD) is a life-threatening complication after allogeneic hematopoietic stem cell (HSCT) or solid organ transplantation.	19060508
Acquired aplastic anemia, Aortic Aneurysm	Stem Cell Exhaustion	About 10-15% of patients with acquired aplastic anemia (AAA) have resistant/recurrent disease not eligible for standard treatment like hematopoietic stem cell transplantation and/or combined immunosuppression.	19061218
Urticaria Pigmentosa, Osteoporosis	Stem Cell Exhaustion	Urticaria pigmentosa patients are at risk for osteoporosis because of elevated heparin and stem-cell factor levels.	19061601
Omenn Syndrome, Primary immune deficiency disorder	Stem Cell Exhaustion	Haematopoietic stem cell transplantation is the treatment of choice for severe primary immunodeficiencies, but only has moderate prognosis in Omenn syndrome as it is complicated by highly activated Omenn T-cells resulting in delayed T-cell engraftment and a high rate of graft failure.	19064334
Peripheral Arterial Diseases	Stem Cell Exhaustion	Endothelial progenitor cells in patients with severe peripheral arterial disease.	19065316
atherosclerotic, Peripheral Arterial Diseases	Stem Cell Exhaustion	The aims of this study were to investigate the interrelationships between endothelial progenitor cells (EPCs), peripheral arterial disease (PAD), and atherosclerotic risk factors, as only limited data are available regarding the EPCs in patients with PAD.	19065316
Mucopolysaccharidoses	Stem Cell Exhaustion	[Treatment of 2 children with mucopolysaccharidosis by allogeneic hematopoietic stem cell transplantation].	19065530
Amyloidosis	Stem Cell Exhaustion	Early intensification and autologous stem cell transplantation in patients with systemic AL amyloidosis: a single-centre experience.	19066891
Kidney Transplantation, Organ Dysfunction Scores	Stem Cell Exhaustion	This case report demonstrates that combined heart and kidney transplantation not systematically associated with stem cell transplantation may be considered an additional therapeutic option in AL-A patients with severe organ dysfunction and partial hematologic remission.	19067666
Up, Multiple Myeloma	Stem Cell Exhaustion	In this study, the effect of different treatment regimens for MM on serum DKK-1 was evaluated and correlated with the response to treatment in 101 myeloma patients receiving bortezomib, thalidomide, lenalidomide, adriamycin and dexamethasone (AD) or high-dose chemotherapy (HDCT) followed by autologous stem cell transplantation (ASCT).	19067746
Cytomegalovirus Retinitis	Stem Cell Exhaustion	Cytomegalovirus encephalitis/retinitis in allogeneic haematopoietic stem cell transplant recipient treated successfully with combination of cidofovir and foscarnet.	19067913
Engraftment syndrome	Stem Cell Exhaustion	Engraftment syndrome following allogeneic hematopoietic stem cell transplantation in children.	19067915
Heart failure	Stem Cell Exhaustion	Cardiac stem cell transplantation has become a promising therapy to treat heart failure in adult patients.	19067928
Heart failure	Stem Cell Exhaustion	Cardiac stem cell therapy proved to be technically feasible, was associated with improvement in cardiac function, and might represent an option before heart transplantation in children with severe heart failure.	19067928
Dilated Cardiomyopathy Pathway	Stem Cell Exhaustion	Intracoronary administration of autologous bone marrow-derived progenitor cells in a critically ill two-yr-old child with dilated cardiomyopathy.	19067928
Heart failure, Doctor of Chiropractic, Critical Illness	Stem Cell Exhaustion	The present case documents for the first time intracoronary administration of autologous bone marrow-derived progenitor cells in a critically ill two-yr-old child with severe heart failure caused by DCM.	19067928
Specialty Type - cancer	Stem Cell Exhaustion	Cancer is an adaptation mechanism of the aged stem cell against stress.	19072256
Specialty Type - cancer	Stem Cell Exhaustion	The hypothesis presented here, which is a radical departure from all previous theories of cancer, explicitly states that cancer is the adaptation of the aged stem cell against sustained stress.	19072256
Malignant Neoplasms, Carcinogenesis	Stem Cell Exhaustion	Cancers have been shown to be clonally derived from a single cell, and so it does seem that stem cells are target cells for carcinogenesis.	19072256
Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0, Anemia, Hemolytic	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic anemia caused by the expansion of a hematopoietic progenitor cell that has acquired a mutation in the X-linked PIGA gene.	19074066
Multiple Myeloma	Stem Cell Exhaustion	In multiple myeloma this has been possible only with the introduction of high-dose therapy plus autologous stem-cell transplantation (ASCT).	19074101
Pancreatic carcinoma	Stem Cell Exhaustion	Pancreatic cancer cells have been shown to possess stem-cell-like properties, especially by reactivating embryonic transcription factors involved in tissue differentiation.	19077462
Overweight	Stem Cell Exhaustion	Endothelial progenitor cell number and colony-forming capacity in overweight and obese adults.	19079361
Adult Glioblastoma, Specialty Type - cancer	Stem Cell Exhaustion	For this reason, the new GM7 glioblastoma cell line represents an important model suitable not only for further studies on glioblastoma biology and cancer stem cells, but particularly for the detailed investigation of the role of nestin in transformed cells.	19082452
Endothelial dysfunction	Stem Cell Exhaustion	In this study we wanted to clarify whether reduced blood levels of circulating endothelial progenitor cells (EPCs), an endogenous repair mechanism to replace dysfunctional endothelium, or elevated endothelial-derived microparticles (EMPs), an indicator and a mediator of increased endothelial cell damage/apoptosis, are an initial step in the pathogenesis of endothelial dysfunction in genetically predisposed subjects.	19087127
Specialty Type - cancer, Glioblastoma	Stem Cell Exhaustion	Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme.	19088037
Adult Glioblastoma	Stem Cell Exhaustion	The stem cell antigen CD133 identifies such a tumorigenic population in a subset of glioblastoma patients.	19088037
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSC) are thought to represent the population of tumorigenic cells responsible for tumor development.	19088037
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Eight patients (1 with AML and 7 with MDS) underwent allogeneic stem cell transplantation, and all but 2 died at a median of 3 months (range, 0.5-11 months) after transplantation.	19090005
Coronary Arteriosclerosis	Stem Cell Exhaustion	Effect of intensive lipid-lowering therapy on telomere erosion in endothelial progenitor cells obtained from patients with coronary artery disease.	19090788
Hypogonadotropic hypogonadism	Stem Cell Exhaustion	Effect of vardenafil on endothelial progenitor cells in hypogonadotrophic hypogonadal patients: role of testosterone treatment.	19094070
HFE wt Allele	Stem Cell Exhaustion	The number of circulating EPCs and progenitor cells (PCs) in HH patients was evaluated after acute vardenafil administration at baseline and after 6 months of T supplementation.	19094070
MMD gene	Stem Cell Exhaustion	An inverse correlation between circulating endothelial progenitor cell numbers and serum levels of vascular endothelial growth factor (r=-0.53; P<0,02) was found in the MMD group.	19095988
MMD gene	Stem Cell Exhaustion	Our results show increased circulating endothelial progenitor cell numbers in MMD, which may play a role in the increased arteriogenesis and angiogenesis in MMD.	19095988
MMD gene	Stem Cell Exhaustion	Moreover, our results suggest that increased circulating endothelial progenitor cell mobilization in MMD may not be entirely mediated by vascular endothelial growth factor or granulocyte-macrophage colony-stimulating factor.	19095988
Moyamoya Disease	Stem Cell Exhaustion	Increased levels of circulating endothelial progenitor cells in patients with Moyamoya disease.	19095988
MMD gene	Stem Cell Exhaustion	In the present study we investigated if circulating endothelial progenitor cells are increasingly mobilized during MMD.	19095988
MMD gene, Cerebral Atherosclerosis	Stem Cell Exhaustion	In MMD patients the number of circulating endothelial progenitor cells was significantly higher than in atherosclerotic cerebrovascular disease patients (P<0.002) and healthy controls (P<0.0001).	19095988
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A similar study was performed for AML SP to further characterize the SP cells with the aim of narrowing down the putatively very low stem cell fraction.	19096043
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In acute myeloid leukemia (AML), apart from the CD34(+)CD38(-) compartment, the side population (SP) compartment contains leukemic stem cells (LSCs).	19096043
leukemia	Stem Cell Exhaustion	This reveals the presence of a low-frequency (median, 0.0016%) SP subfraction as a likely candidate to be enriched for leukemia stem cells.	19096043
Glioma	Stem Cell Exhaustion	The aim of this study was to determine the anatomic relationship of human gliomas to the lining of the ventricular walls, known as the subventricular zone, an area replete with neural stem cells.	19097905
Hematologic Neoplasms, Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Taken together, although primary plasma cell leukemia is a rare hematologic malignancy with poor prognosis, the intensive chemotherapy followed by tandem autologous peripheral blood stem cell transplantation may well improve the clinical outcome.	19098420
Hematologic Neoplasms	Stem Cell Exhaustion	[Allogeneic peripheral blood stem cell transplantation for 75 cases of hematologic malignancies].	19099638
Hematologic Neoplasms	Stem Cell Exhaustion	The aim of this study was to explore the clinical effect and complications of allogeneic peripheral blood stem cell transplantation (allo-PBSCT) in hematologic malignancies through retrospective analysis of 75 patients (42 male, 33 female; aged from 13 to 72 years old) received allo-PBSCT from HLA matched (n=61) or haploidentical donors (n=14).	19099638
Atrial Fibrillation by ECG Finding	Stem Cell Exhaustion	[Comparison of peripheral blood hematopoietic progenitor cells among patients with paroxysmal, permanent atrial fibrillation or sinus rhythm].	19100027
Atrial Fibrillation, Atrial Fibrillation by ECG Finding	Stem Cell Exhaustion	To compare peripheral blood hematopoietic progenitor cells (HPCs), plasma atrial natriuretic peptide (ANP) and stromal cell-derived factor-1alpha (SDF-1alpha) among patients with paroxysmal, permanent atrial fibrillation (AF) or sinus rhythm.	19100027
Coronary Lesions Treated, Coronary Arteriosclerosis	Stem Cell Exhaustion	[Association among circulating endothelial progenitor cells, insulin resistance and severity of coronary lesions in patients with coronary artery disease].	19100113
Coronary Lesions Treated, Coronary Arteriosclerosis	Stem Cell Exhaustion	To investigate the correlation between the number and activity of circulating endothelial progenitor cells (EPCs), insulin resistance and severity of coronary lesions in patients with coronary artery disease (CAD).	19100113
BCR gene	Stem Cell Exhaustion	In one of the ALL cases, relapse during chemotherapy, 5 months from diagnosis, was accompanied by clonal evolution; in another ALL case, early relapse appeared 51 days after allogeneic stem cell transplantation.	19100515
Gain, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Minimal residual disease (MRD) diagnostics in acute myeloid leukemia (AML) gain increasing importance after allogeneic stem cell transplantation (SCT).	19100523
Osteopetrosis	Stem Cell Exhaustion	Low-dose busulphan conditioning and neonatal stem cell transplantation preserves vision and restores hematopoiesis in severe murine osteopetrosis.	19100677
Thrombasthenia	Stem Cell Exhaustion	Allogeneic stem cell transplantation for Glanzmann thrombasthenia.	19101997
Heart failure, Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	[Assessment of therapeutic effects of stem cell transplantation in heart failure patients with old myocardial infarction by magnetic resonance imaging].	19102907
Heart failure, Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	To evaluate the therapeutic effects of stem cell transplantation in heart failure patients with old myocardial infarction (OMI) by MRI.	19102907
Heart failure	Stem Cell Exhaustion	Heart failure patients [NYHA 2.7 +/- 0.7, male = 18, mean age (59.5 +/- 10.1) y] with OMI were randomly divided into 2 groups (group A: CABG + stem cell transplantation, group B: CABG; n = 10 each).	19102907
Heart failure, Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Stem cell therapy on top of CABG aggravated LV remodeling in heart failure patients with old myocardial infarction.	19102907
Mycoses	Stem Cell Exhaustion	Clinical impact of enhanced diagnosis of invasive fungal disease in high-risk haematology and stem cell transplant patients.	19103864
Usual Severity Pain	Stem Cell Exhaustion	Three-tunnels core decompression with implantation of bMSCs and DBM not only removal the focus of disease, but also use DBM the induction of bone and autologous hone marrow stem cells to differentiate the functions of the femoral head can be resumed loading structure, eliminate pain,improve joint function.	19105378
Acute myocardial infarction	Stem Cell Exhaustion	Improved regional function after autologous bone marrow-derived stem cell transfer in patients with acute myocardial infarction: a randomized, double-blind strain rate imaging study.	19106196
Myocardial, Infarction	Stem Cell Exhaustion	Four months after revascularization and progenitor cell/placebo transfer, regional myocardial deformation (rate) improved significantly more in the infarct segments of BMPC patients (treatment effect on end-systolic strain: -3.7 +/- 1.0%, P = 0.0003; peak-systolic strain rate: -0.20 +/- 0.07 s(-1), P = 0.0035).	19106196
Acute myocardial infarction	Stem Cell Exhaustion	To investigate whether intracoronary transfer of bone marrow progenitor cells (BMPCs) early after reperfusion of an acute myocardial infarction improves regional myocardial function in a randomized double-blind, placebo-controlled strain rate imaging study.	19106196
Infection	Stem Cell Exhaustion	Patients with severe infections are thought to be ineligible for cord blood stem cell transplantation (CBT) because the conventional 5-6 day-conditioning regimens potentially makes them susceptible to fatal infections by the time neutrophil engraftment occurs.	19107331
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Nestin and CD133: valuable stem cell-specific markers for determining clinical outcome of glioma patients.	19108713
Glioma	Stem Cell Exhaustion	The aim of this study was to investigate the correlation of the stem cell markers Nestin and CD133 expression with the grading of gliomas, and to evaluate their prognostic value.	19108713
Acute Coronary Syndrome	Stem Cell Exhaustion	Expression of stromal-cell-derived factor-1 on circulating platelets is increased in patients with acute coronary syndrome and correlates with the number of CD34+ progenitor cells.	19109356
Coronary Arteriosclerosis	Stem Cell Exhaustion	In a subgroup of patients with coronary artery disease, platelet-bound SDF-1, but not other platelet activation markers, significantly correlated with the number of circulating CD34(+) progenitor cells (r = 0.252; P = 0.002) or CD34(+)/CD133(+) endothelial progenitor cells (r = 0.352; P = 0.008).	19109356
Anemia, Macrocytosis result	Stem Cell Exhaustion	Our analyses identified defects in mature blood cells, including macrocytosis and anemia, as well as abnormalities in fetal liver and bone marrow stem and progenitor cell function.	19109561
MYELODYSPLASTIC SYNDROME, Multiple Myeloma, Amyloidosis, Thalassemia, Aplastic Anemia, Pancreatoblastoma, Nephroblastoma, Systemic Scleroderma, Pfaundler-Hurler Syndrome, Sickle cell-thalassemia disease, Renal Cell Carcinoma Pathway, Mucopolysaccharidoses, Acute lymphocytic leukemia, Leukemia, Myelocytic, Acute, Myeloid Leukemia, Chronic, Neoplastic Stem Cells, Chronic Lymphocytic Leukemia, Lymphoma, Non-Hodgkin, Histiocytosis, Malignant neoplasm of ovary, Hodgkin Disease, Ewings sarcoma, MS gene, Fanconi Anemia, Severe congenital neutropenia, Paroxysmal nocturnal hemoglobinuria, Chediak-Higashi Syndrome, Osteopetrosis, Rhabdomyosarcoma, Malignant neoplasm of testis, Central neuroblastoma, Niemann-Pick Diseases, Childhood Breast Carcinoma, Nasopharyngeal carcinoma, Anemia, Sickle Cell, Medulloblastoma	Stem Cell Exhaustion	Stem cell transplantation was performed for various diseases including acute myelogenous leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia, chronic lymphoblastic leukemia, thalassemia major, sickle cell thalassemia, sickle cell disease, multiple myeloma, myelodysplasia, mucopolysaccharidosis, paroxysmal nocturnal hemoglobinuria, non-Hodgkin's lymphoma, Hodgkin's disease, severe aplastic anemia, plasma cell leukemia, Niemann-Pick disease, Fanconi anemia, severe combine immunodeficiency, congenital neutropenia, leukocyte adhesion deficiencies, Chediak-Higashi syndrome, osteopetrosis, histiocytosis X, Hurler syndrome, amyloidosis, systemic sclerosis, breast cancer, Ewing's sarcoma, testicular cancer, germ cell tumors, neuroblastoma, medulloblastoma, renal cell carcinoma, nasopharyngeal carcinoma, ovarian cancer, Wilms' tumor, rhabdomyosarcoma, pancreatoblastoma, and multiple sclerosis.	19111033
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Peripheral blood CD5-positive B lymphocytes (B-1a cells) after allogeneic stem cell transplantation for acute myeloid leukaemia in humans.	19112737
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Cytometric analyses were performed over time on 11 consecutive patients undergoing allogeneic peripheral blood stem cell transplantation for acute myeloid leukaemia in our Haematology Unit and the results were compared with available data regarding B- 1a cell reconstitution after allogeneic bone marrow stem cell transplantation.	19112737
Mycoses	Stem Cell Exhaustion	Epidemiology and outcome of invasive fungal infection in adult hematopoietic stem cell transplant recipients: analysis of Multicenter Prospective Antifungal Therapy (PATH) Alliance registry.	19115967
Mycoses	Stem Cell Exhaustion	With use of data from the Prospective Antifungal Therapy (PATH) Alliance registry, we performed this multicenter, prospective, observational study to assess the epidemiologic characters and outcomes of invasive fungal infection (IFI) in hematopoietic stem cell transplant (HSCT) recipients.	19115967
Acute myocardial infarction	Stem Cell Exhaustion	Mobilization of bone marrow-derived Oct-4+ SSEA-4+ very small embryonic-like stem cells in patients with acute myocardial infarction.	19118716
Acute myocardial infarction	Stem Cell Exhaustion	This study sought to assess of the mobilization of nonhematopoietic very small embryonic-like stem cells (VSELs) in acute myocardial infarction (MI).	19118716
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Diffuse large B-cell lymphoma (DLBCL) in Koreans is frequently accompanied by extranodal (EN) disease at the time of autologous stem cell transplantation (ASCT).	19119255
Lymphoma	Stem Cell Exhaustion	The stable mortality rates during the 1990s (in the face of increasing incidence) might have been because of introduction of novel therapies such as autologous stem cell transplant for relapsed diffuse large cell lymphoma or the purine analogue-based therapy for indolent lymphomas.	19120550
Neutropenia, Lymphoma	Stem Cell Exhaustion	Late onset neutropenia and immunoglobulin suppression of the patients with malignant lymphoma following autologous stem cell transplantation with rituximab.	19122357
BCR gene	Stem Cell Exhaustion	Some adult options, such as allogeneic stem-cell transplantation for patients with high-risk ALL, were nevertheless retained.	19124805
Hematological Disease, Neoplasms	Stem Cell Exhaustion	The purpose of this study was to analyse our experience of early discharge 2 days after high-dose melphalan (HDM) (Day-1) followed by peripheral blood stem cell re-infusion (Day-0) and re-admission on Day +5 in patients with hematological diseases or solid tumors.	19125385
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Hematopoietic stem cell transplantation for core binding factor acute myeloid leukemia: t(8;21) and inv(16) represent different clinical outcomes.	19126873
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We analyzed 338 adult patients with acute myeloid leukemia (AML) with t(8;21) and inv(16) undergoing stem cell transplantation (SCT) who were registered in the Japan Society for Hematopoietic Cell Transplantation database.	19126873
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The Wnt/beta-catenin signaling is important for controlling self-renewal of hematopoietic stem cells and its constitutive activation has recently been documented in a significant proportion of acute myeloid leukemia (AML) cases.	19127593
Hematologic Neoplasms, Mycoses	Stem Cell Exhaustion	Invasive fungal infections (IFI) are an important complication in hematologic malignancies and stem-cell transplantation (SCT).	19131772
Trichosporonosis, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	An 18-year-old man with myelodysplastic syndrome after stem-cell transplantation developed breakthrough trichosporonosis while being administered voriconazole, a broad-spectrum triazole.	19131780
Immunocompromised Host, Fungemia, Trichosporon	Stem Cell Exhaustion	This case illustrates that the serum polymerase chain reaction assay might be effective for early detection of fungemia in immunocompromised patients, including recipients of stem-cell transplants undergoing prophylactic antifungal therapy using voriconazole, which cannot be assumed to always provide complete protection against Trichosporon infection.	19131780
Hematological Disease, Mycoses	Stem Cell Exhaustion	To investigate the efficacy and safety of intravenous itraconazole for the treatment of invasive fungal infection (IFI) in patients with hematological disease or undergoing allogeneic hematopoietic stem cell transplantation (HSCT).	19134309
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Identification of genomic lesions in progenitor cells of patients with myelodysplastic syndrome (MDS) could lead to the discovery of new disease-specific genes and may be of prognostic value.	19135900
Multiple Myeloma	Stem Cell Exhaustion	Changes in quality-of-life and psychosocial adjustment among multiple myeloma patients treated with high-dose melphalan and autologous stem cell transplantation.	19135938
Multiple Myeloma	Stem Cell Exhaustion	High-dose melphalan and autologous hematopoietic stem cell transplantation (HSCT) is a standard treatment for myeloma, but very little is known about the psychosocial or quality-of-life difficulties that these patients encounter during treatment.	19135938
Fatigue, Usual Severity Pain	Stem Cell Exhaustion	At stem cell collection, physical deficits were common, with most patients scoring 1 standard deviation below population norms for physical well-being (70.2%) and functional well-being (57.5%), and many reporting at least moderate fatigue (94.7%) and pain (39.4%).	19135938
Renal Insufficiency	Stem Cell Exhaustion	Study of kidney function impairment after reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation.	19135939
Kidney Failure, Acute	Stem Cell Exhaustion	Acute renal failure (ARF) is a life-threatening complication after allogeneic stem cell transplantation (Allo-HSCT).	19135939
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Allogeneic stem cell transplantation for adults with myelodysplastic syndromes: importance of pretransplant disease burden.	19135940
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Allogeneic stem cell transplantation is the only known curative therapy for myelodysplastic syndromes (MDS).	19135940
PAFAH1B1 wt Allele	Stem Cell Exhaustion	We present the transplant outcomes for 84 adult MDS patients, median age 50 (18-69 years), undergoing allogeneic hematopoietic stem cell transplantation (HSCT) at the University of Minnesota between 1995 and 2007.	19135940
leukemia	Stem Cell Exhaustion	In the era of cytomegalovirus (CMV)-preemptive therapy, it is unclear whether CMV serostatus of donor or recipient affects outcome of allogeneic hematopoietic stem cell transplantation (HSCT) among children with leukemia.	19135943
Central Line Complication	Stem Cell Exhaustion	Early central nervous complications (CNS) are significant after allogeneic stem cell transplantation; however, the clinical characteristics of early CNS complications have not yet been well described.	19135947
Multiple Myeloma	Stem Cell Exhaustion	A Phase II trial of autologous stem cell transplantation followed by mini-allogeneic stem cell transplantation for the treatment of multiple myeloma: an analysis of Eastern Cooperative Oncology Group ECOG E4A98 and E1A97.	19135946
Multiple Myeloma	Stem Cell Exhaustion	Conventional allogeneic hematopoietic stem cell transplantation (HSCT) for multiple myeloma is associated with high transplantation-related mortality (TRM).	19135946
Graft-vs-Host Disease	Stem Cell Exhaustion	A calcineurin inhibitor combined with methotrexate is the standard prophylaxis for graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT).	19135948
Lymphoproliferative Disorders	Stem Cell Exhaustion	Stem cell mobilization with a single dose of PEGFIL was, therefore, comparable to that achieved using daily FIL in patients with lymphoproliferative diseases.	19139894
Chronic Lymphocytic Leukemia, Lymphoma, Multiple Myeloma, Lymphoproliferative Disorders	Stem Cell Exhaustion	In the present study, we evaluated the ability of PEGFIL to mobilize stem cells in 38 consecutive patients with lymphoproliferative diseases (multiple myeloma, n = 18; lymphomas, n = 15; chronic lymphocytic leukemia, n = 5).	19139894
Specialty Type - cancer	Stem Cell Exhaustion	The purpose of this study was to assess late effects of cytotoxic therapy with hematopoietic stem cell transplantation (HCT) on dental development in survivors of childhood cancer.	19139926
Acute lymphocytic leukemia	Stem Cell Exhaustion	Clinical risk classification is inaccurate in predicting relapse in adult patients with acute lymphoblastic leukemia, sometimes resulting in patients receiving inappropriate chemotherapy or stem cell transplantation (SCT).	19141862
Hematologic Neoplasms, Hepatitis C, HIV Infections	Stem Cell Exhaustion	Impact of hepatitis C virus seropositivity on survival after allogeneic hematopoietic stem cell transplantation for hematologic malignancies.	19144658
Allogeneic Hematopoietic Stem Cell Transplantation, Hepatitis C, Liver Dysfunction	Stem Cell Exhaustion	Because hepatitis C virus infection causes hepatic and immunological dysfunction, we hypothesized that seropositivity for this virus could be associated with increased non-relapse mortality after allogeneic hematopoietic stem cell transplantation.	19144658
Hepatitis C	Stem Cell Exhaustion	We performed a case-control study of the outcomes of patients who were hepatitis C virus seropositive at the time of allogeneic hematopoietic stem cell transplantation (N=31).	19144658
Hepatitis C, Liver Dysfunction	Stem Cell Exhaustion	Patients positive for hepatitis C virus were considered candidates for stem cell transplantation only if they had no significant evidence of hepatic dysfunction.	19144658
Hepatitis C, HIV Infections, Liver Dysfunction	Stem Cell Exhaustion	Hepatitis C virus seropositivity is a significant risk factor for non-relapse mortality after allogeneic hematopoietic stem cell transplantation even in patients with normal or minimally abnormal liver function tests.	19144658
Hematologic Neoplasms	Stem Cell Exhaustion	Haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for treatment of hematologic malignancies in children.	19147085
Neoplasms, Glioblastoma	Stem Cell Exhaustion	Cells isolated from seven glioblastomas (GBM 1-7) and grown using neural stem cell permissive conditions were characterized for in vivo tumorigenicity, expression of tumor stem cell markers (CD133, nestin), and multilineage differentiation properties, confirming that these cultures are enriched in TICs.	19147502
Glioblastoma Multiforme Pathway, Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Because a subpopulation of cancer stem cells (tumor-initiating cells, TICs) is believed to be responsible for the development, progression, and recurrence of many tumors, we evaluated the in vitro sensitivity of human glioma TICs to epidermal growth factor receptor (EGFR) kinase inhibitors (erlotinib and gefitinib) and possible molecular determinants for their effects.	19147502
leukemia	Stem Cell Exhaustion	We propose that short and dysfunctional telomeres limit normal stem cell proliferation and predispose for leukemia by selection of stem cells with defective DNA damage responses that are prone to genome instability.	19147845
Chronic Lymphocytic Leukemia, Antigens, Viral	Stem Cell Exhaustion	In conclusion, our findings indicate that the interactions of CLL progenitor cells expressing distinctive IGHV4-34 BCRs with viral antigens/superantigens might facilitate clonal expansion and, eventually, leukemic transformation.	19148139
Cytomegalovirus Infections	Stem Cell Exhaustion	Oral valganciclovir as preemptive therapy is effective for cytomegalovirus infection in allogeneic hematopoietic stem cell transplant recipients.	19148587
Communicable Diseases	Stem Cell Exhaustion	Between March 2007 and January 2008, the safety and efficacy of oral valganciclovir (VGC) preemptive therapy for cytomegalovirus (CMV) infection was evaluated in ten consecutive patients who received allogeneic hematopoietic stem cell transplantation (HSCT).	19148587
Fibrosis Assessment	Stem Cell Exhaustion	Fibrocytes are circulating mesenchymal cell progenitors that are involved in tissue repair and fibrosis.	19151190
Coronary Arteriosclerosis	Stem Cell Exhaustion	The potential of circulating endothelial progenitor cells to form colonies is inversely proportional to total vascular risk score in patients with coronary artery disease.	19151462
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Both expanded and uncultured mesenchymal stem cells from MDS patients are genomically abnormal, showing a specific genetic profile for the 5q- syndrome.	19151777
PAFAH1B1 wt Allele, Chromosome Aberrations, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	The presence of cytogenetic aberrations on mesenchymal stem cells (MSC) from myelodysplastic syndrome (MDS) patients is controversial.	19151777
Li-Fraumeni Syndrome	Stem Cell Exhaustion	Donor killer cell immunoglobulin-like receptor (KIR)-ligand incompatibility is associated with decreased relapse incidence (RI) and improved leukemia-free survival (LFS) after haploidentical and HLA-mismatched unrelated hematopoietic stem cell transplantation.	19151783
Sleep disturbances	Stem Cell Exhaustion	Sleep disturbances and emotional distress in the acute course of hematopoietic stem cell transplantation.	19151796
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Bone marrow-derived CD34+ hematopoietic progenitor cells from six healthy persons and 16 patients with MDS were analyzed on cDNA macroarrays comprising 1,185 genes.	19152102
Fracture	Stem Cell Exhaustion	Application of a new chair-side method for the harvest of mesenchymal stem cells in a patient with nonunion of a fracture of the atrophic mandible--a case report.	19155179
Mandibular Fractures	Stem Cell Exhaustion	This case report describes a new clinical method for chair-side processing of a cell mixture which contains mesenchymal stem cells (MSCs) which was applied for the first time in the treatment of a nonunion of an atrophic fractured mandible.	19155179
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Our results provide useful information for therapeutic approaches in AML, which, like haploidentical stem cell transplantation, rely on a sufficient NK cell response.	19155305
Zygomycosis	Stem Cell Exhaustion	Due to the increasing use of potent immunosuppression, stem cell and organ transplants and possibly selection for Zygomycetes by prior treatment with broad-spectrum antifungal therapy, the incidence of zygomycosis is rising.	19155544
Hypogonadism, Lymphoma	Stem Cell Exhaustion	Because of the adverse health effects following long-lasting endocrine hypogonadism, gonadal hormones should be assessed regularly in male lymphoma survivors, especially after treatment with alkylating agents and high-dose chemotherapy with autologous stem cell support and in male patients who are 50 years and older.	19156143
Graft-vs-Host Disease	Stem Cell Exhaustion	Ocular surface reconstruction in graft-versus-host disease with HLA-identical living-related allogeneic cultivated limbal epithelium after hematopoietic stem cell transplantation from the same donor.	19158575
Stable chronic Graft vs Host Disease, Intracapsular cataract extraction	Stem Cell Exhaustion	Review the clinical findings in a 58-year-old woman with bilateral limbal stem cell deficiency caused by cGVHD who underwent ocular surface reconstruction on the left eye with cultivated limbal epithelial cells (LECs) on intact human amniotic membrane combined with extracapsular cataract extraction and intraocular lens implantation.	19158575
Cornea	Stem Cell Exhaustion	At the present state, after a follow-up of 31 months, the patient shows a successful ocular surface reconstruction with a clear, smooth, and stable corneal ocular surface without recurrence of limbal stem cell deficiency.	19158575
Stable chronic Graft vs Host Disease	Stem Cell Exhaustion	The technique of HLA-typed allogeneic ex vivo expansion of LECs harvested from the same living-related donors who already donated hematopoietic stem cells offers a possibility to reconstruct ocular surface in cGVHD.	19158575
Aplastic Anemia	Stem Cell Exhaustion	We analyzed the medical records of 508 patients with aplastic anemia after excluding patients below 15 years of age or those who underwent stem cell transplantation between January 1, 2002, and December 31, 2007.	19165598
Colorectal Carcinoma	Stem Cell Exhaustion	Cell division per se may be an important mechanism underlying the increased incidence of colorectal cancer with ageing, because the neoplastic phase appears more commonly to start from mitotically older crypt stem cells.	19165870
Hypernatremia	Stem Cell Exhaustion	Iron overload might be an important contributor to nonrelapse mortality (NRM) in hematopoietic stem cell transplantation (HSCT).	19167679
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Assessment of the hematopoietic cell transplantation comorbidity index in non-Hodgkin lymphoma patients receiving reduced-intensity allogeneic hematopoietic stem cell transplantation.	19167682
Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	The hematopoietic cell transplantation comorbidity index (HCT-CI), a weighted index of 17 pretransplantation comorbidities, has been validated in nonmyeloablative and myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) studies, but it has not been specifically tested in patients with non-Hodgkin lymphoma (NHL) receiving reduced-intensity conditioning (RIC).	19167682
Lymphoma, Non-Hodgkin, Multiple Myeloma	Stem Cell Exhaustion	Treatment with plerixafor in non-Hodgkin's lymphoma and multiple myeloma patients to increase the number of peripheral blood stem cells when given a mobilizing regimen of G-CSF: implications for the heavily pretreated patient.	19167685
Multiple Myeloma, Lymphoma, Non-Hodgkin, Lymphoma, Non-Hodgkin, Familial, Toxic effect, Morular Metaplasia of the Endometrium	Stem Cell Exhaustion	We investigated the efficacy and toxicity of combining granulocyte-colony stimulating factor (G-CSF) at standard doses with plerixafor, a CXCR4 inhibitor, to mobilize stem cells in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM).	19167685
Cessation of life, Chronic graft-versus-host disease	Stem Cell Exhaustion	The major determinants of disease control after NST were the use of a peripheral blood stem cell graft and donor chimerism of at least 95%, whereas the major determinant of death was immunosuppression for chronic graft-versus-host disease.	19168784
Stable chronic Graft vs Host Disease, Malignant Neoplasms, Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic graft-versus-host disease (cGVHD) causes significant morbidity and mortality in patients otherwise cured of malignancy after hematopoietic stem cell transplantation (HSCT).	19168788
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	In a pilot trial, we evaluated the feasibility of stem cell mobilization with vinorelbine/G-CSF in patients with lymphoma, a regimen allowing precise timing and harvesting of sufficient stem cells in myeloma patients.	19169288
Lymphoma	Stem Cell Exhaustion	In conclusion, vinorelbine/G-CSF allows accurate timing and safe harvesting of sufficient stem cells in patients with malignant lymphoma.	19169288
Neoplasms	Stem Cell Exhaustion	The efficacy of pegfilgrastim+/-chemotherapy for mobilizing stem cells in patients with solid tumours was assessed.	19169289
Acute lymphocytic leukemia	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation in adult acute lymphoblastic leukemia: still not out of fashion.	19172272
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	The role of autologous hematopoietic stem cell transplantation (autoHSCT) in adult acute lymphoblastic leukemia (ALL) is still unclear.	19172272
Nephritis, Interstitial, Communicable Diseases	Stem Cell Exhaustion	[Acute necrotizing tubulointerstitial nephritis due to adenoviral infection following hematopoietic stem cell transplantation: clinical findings obtained from 4 autopsy cases].	19172806
Nephritis, Interstitial, Kidney Failure, Acute	Stem Cell Exhaustion	Once adenovirus infection extends to the kidney from the bladder in the immunosuppressive state after hematopoietic stem cell transplantation, most patients develop acute renal failure due to adenovirus-associated necrotizing tubulointerstitial nephritis.	19172806
Communicable Diseases	Stem Cell Exhaustion	In the 6 years from 2000 to 2006, we retrospectively investigated the characteristics of adenovirus infection in 402 patients who had received a hematopoietic stem cell transplantation in our hospital.	19172806
Hemorrhagic cystitis	Stem Cell Exhaustion	The incidence of adenovirus-associated hemorrhagic cystitis in patients who had received a hematopoietic stem cell transplantation was 3.5% (14/402).	19172806
Chronic heart failure	Stem Cell Exhaustion	Circulating CD34+/KDR+ endothelial progenitor cells are reduced in chronic heart failure patients as a function of Type D personality.	19173675
Nonscarring alopecia	Stem Cell Exhaustion	Stem cell markers (cytokeratin 15, CD34 and nestin) in primary scarring and nonscarring alopecia.	19175602
Alopecia	Stem Cell Exhaustion	Our findings of differential follicular localization of stem cells underscore follicular progenitor cell heterogeneity and suggest the target in scarring alopecia is not merely follicular bulge stem cells but involves stem cells in the inner and outer aspect of the ORS.	19175602
Alopecia	Stem Cell Exhaustion	Enhanced expression of nestin in the infundibular region in scarring alopecia indicates availability of an accessible, in vivo niche of potential utility as an autologous source of stem cells for therapeutic application.	19175602
Neoplasms	Stem Cell Exhaustion	In addition, malignant conversion is associated with increased number of putative tumor stem cells.	19176372
Lupus Erythematosus, Systemic	Stem Cell Exhaustion	Increased expression of CD40 on bone marrow CD34+ hematopoietic progenitor cells in patients with systemic lupus erythematosus: contribution to Fas-mediated apoptosis.	19180486
Lupus Erythematosus, Systemic, Encephalitis, St. Louis	Stem Cell Exhaustion	Patients with systemic lupus erythematosus (SLE) display increased apoptosis of bone marrow (BM) CD34+ hematopoietic progenitor cells.	19180486
Encephalitis, St. Louis	Stem Cell Exhaustion	These data reveal a novel role for the CD40/CD40L dyad in SLE by demonstrating that up-regulation and induction of CD40 on BM CD34+ cells from patients with SLE contribute to the amplification of Fas-mediated apoptosis of progenitor cells.	19180486
Neutropenia, Fungemia	Stem Cell Exhaustion	In multivariate analysis, patients having C. lusitaniae fungemia were more likely to have neutropenia (p=0.001), stem cell transplantation (p=0.014) and to have received prior antifungals (p=0.04).	19180749
Neutropenia, Fungemia	Stem Cell Exhaustion	Clinically, C. lusitaniae fungemia was more frequently associated with stem cell transplant and neutropenia.	19180749
Pancreatic carcinoma	Stem Cell Exhaustion	[Expression of prostate stem cell antigen and Claudin-4 in human pancreatic carcinoma].	19180924
Pancreatic carcinoma	Stem Cell Exhaustion	To investigate the expressions of prostate stem cell antigen (PSCA) and Claudin-4 in human pancreatic carcinoma and to discuss its role in the ontogenesis of pancreatic cancer.	19180924
Specialty Type - cancer	Stem Cell Exhaustion	Low-dose oral metronomic chemotherapy prevents mobilization of endothelial progenitor cells into the blood of cancer patients.	19181016
Neoplasms	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPCs) actively supply cells that may participate in tumor angiogenesis.	19181016
Colorectal Carcinoma, Malignant tumor of colon	Stem Cell Exhaustion	Noncolonic cancer stem cells in bone marrow of colorectal cancer patients.	19183332
Colorectal Carcinoma, Specialty Type - cancer, Cytogenetic Complete Response, Secondary malignant neoplasm of liver	Stem Cell Exhaustion	To investigate whether preoperative noncolonic cancer stem cells in bone marrow (BM) of R0 colorectal cancer (CRC) patients are cancer cells and impact on liver metastases (LM) rates.	19183332
Malignant tumor of colon	Stem Cell Exhaustion	Noncolonic cancer stem cells were defined according to UICC.	19183332
Malignant tumor of colon	Stem Cell Exhaustion	Noncolonic cancer stem cells in BM of PT mutation or MSI-positive patients were isolated with immunobeads coated with magnetically labelled anti-human epithelial antigen antibody and DNA-screened for mutations.	19183332
Specialty Type - cancer	Stem Cell Exhaustion	Twenty-five (2-170) noncolonic cancer stem cells were found in BM of 40 patients.	19183332
Specialty Type - cancer	Stem Cell Exhaustion	The same gene mutations or MSI were not found in noncolonic cancer stem cells of the BM of these patients.	19183332
Cessation of life, Malignant tumor of colon	Stem Cell Exhaustion	Noncolonic cancer stem cells in BM had no impact on LM rates, cancer-specific death rates, or all death rates.	19183332
Specialty Type - cancer, Cytogenetic Complete Response	Stem Cell Exhaustion	Preoperative noncolonic cancer stem cells in BM of R0 CRC patients were not cancer cells and had no impact on LM rates.	19183332
Central Neurocytoma	Stem Cell Exhaustion	This case seems to be in agreement with the hypothesis that central neurocytoma arises from the progenitor cells with potential for both neuronal and glial differentiation.	19183852
Heart failure	Stem Cell Exhaustion	We report the case of a patient in whom severe heart failure symptoms as a consequence of cardiac AL-amyloidosis resolved after tandem high-dose melphalan therapy followed by autologous blood-stem cell transplantation.	19183921
Multiple Myeloma	Stem Cell Exhaustion	Investigating the prognostic value of CT antigen expression in myeloma patients after allogeneic stem cell transplantation, we found that expression of genes, such as MAGE-C1, represents an important indicator of early relapse and dramatically reduced survival.	19190130
Tumor necrosis	Stem Cell Exhaustion	A 'random forest' classification algorithm was used with these parameters to define a 6-analyte panel, consisting of macrophage inflammatory protein-1alpha, carcinoembryonic antigen, stem cell factor, tumor necrosis factor-receptor I, interferon-gamma, and tumor necrosis factor-alpha, that was the optimum combination of biomarkers for identifying a patient's pathologic nodal status.	19190517
Amyotrophic Lateral Sclerosis	Stem Cell Exhaustion	Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients.	19191058
Antilymphocyte Serum	Stem Cell Exhaustion	Stem-cell transplantation in the motor cortex delays ALS progression and improves quality of life.	19191058
Neurodegenerative Disorders, Antilymphocyte Serum	Stem Cell Exhaustion	Stem cells may provide an alternative treatment for ALS and other neurodegenerative diseases.	19191058
Antilymphocyte Serum	Stem Cell Exhaustion	The autologous transplantation of CD133(+) stem cells into the frontal motor cortex is a safe and well-tolerated procedure in ALS patients.	19191058
Central neuroblastoma	Stem Cell Exhaustion	A 7-year-old male with neuroblastoma received ex vivo-expanded donor CD4(+) T lymphocyte infusion (CD4(+) DLI) after recurrence in the bone marrow following allogeneic hematopoietic stem cell transplantation from his HLA-identical mother.	19191346
Atherosclerosis	Stem Cell Exhaustion	Moreover, no signs of cardiovascular or atherosclerotic lesions were noted despite an elevated plasma cholesterol level (339 mg/dL after seven yr of follow-up) resistant to drug therapy and stem cell autotransplantation.	19191809
Central Nervous System Anaplastic Large Cell Lymphoma	Stem Cell Exhaustion	A 9-year-old immunocompetent male patient with primary central nervous system anaplastic large cell lymphoma was treated with 5 cycles of intensive chemotherapy including high-dose Ara-C, high-dose methotrexate, etoposide, and carmustine along with intraventricular chemotherapy followed by high-dose thiotepa and carboplatin with autologous peripheral blood hematopoietic stem cell transplantation.	19194199
Specialty Type - cancer	Stem Cell Exhaustion	We proposed that epithelial tissue stem cells and their cancer stem cell (CSC) counterparts may also share this property.	19194462
Specialty Type - cancer	Stem Cell Exhaustion	Association of reactive oxygen species levels and radioresistance in cancer stem cells.	19194462
Neoplasms	Stem Cell Exhaustion	These results indicate that, similar to normal tissue stem cells, subsets of CSCs in some tumours contain lower ROS levels and enhanced ROS defences compared to their non-tumorigenic progeny, which may contribute to tumour radioresistance.	19194462
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	The hematopoietic cell transplantation comorbidity index (HCT-CI) predicts clinical outcomes in lymphoma and myeloma patients after reduced-intensity or non-myeloablative allogeneic stem cell transplantation.	19194465
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Cytomorphology was characterized by parallel positive myeloperoxidase and non-specific esterase staining, therefore, French-American-British (FAB)-classification was impossible and origin of the AML with t(8;16) from an early stem cell with myeloid and monoblastic potential is hypothesized.	19194466
Multiple Myeloma	Stem Cell Exhaustion	Single daily dose of intravenous busulfan and melphalan as a conditioning regimen for patients with multiple myeloma undergoing autologous stem cell transplantation: a phase II trial.	19197734
Toxic effect, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We evaluated the toxicity and outcome of a conditioning regimen comprising intravenous (iv) busulfan (BU) and melphalan (MEL) in 55 patients (median age, 61 years; range, 34-71) with multiple myeloma (MM) undergoing autologous stem-cell transplantation (ASCT).	19197734
Specialty Type - cancer, Gastrointestinal mucositis	Stem Cell Exhaustion	Self-reported experience of mucositis in cancer patients who underwent conditioning regimen and stem cell transplantation.	19198890
Gastrointestinal mucositis	Stem Cell Exhaustion	This study was done to evaluate the frequency and severity of mucositis in the early period of stem cell transplantation (SCT) and the relation of conditioning regimens with mucositis.	19198890
Kidney Failure	Stem Cell Exhaustion	Corneal limbal insufficiency was suggested to be a premature aging sign resulting from a deficiency in corneal stem cell activity, a biological process caused by underlying telomeric defect in this disease.	19199342
Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology	Stem Cell Exhaustion	Prior studies showed that immune inhibitory CD34(+) progenitor cells, whose numbers are increased in head and neck squamous cell carcinoma (HNSCC) patients, can be differentiated into immune stimulatory dendritic cells by culture with 1alpha,25-dihydroxyvitamin D(3) (1,25[OH](2)D(3)).	19201295
Lymphoma, Follicular	Stem Cell Exhaustion	Transformation of follicular lymphoma to diffuse large B-cell lymphoma may occur by divergent evolution from a common progenitor cell or by direct evolution from the follicular lymphoma clone.	19202129
Colorectal Carcinoma	Stem Cell Exhaustion	Reduced-intensity allogeneic hematopoietic stem cell transplantation in metastatic colorectal cancer as a novel adoptive cell therapy approach.	19203723
Colorectal Carcinoma	Stem Cell Exhaustion	Reduced-intensity conditioning (RIC) regimens for allogeneic hematopoietic stem cell transplantation (HCT) allowed the existence of an allogeneic cell-mediated antitumor effect in metastatic colorectal cancer (mCRC) to be explored.	19203723
Failure, Chronic graft-versus-host disease, Hematologic Neoplasms	Stem Cell Exhaustion	Prolonged chronic graft-versus-host disease is a risk factor for thyroid failure in long-term survivors after matched sibling donor stem cell transplantation for hematologic malignancies.	19203730
Bronchiolitis Obliterans	Stem Cell Exhaustion	High-resolution CT findings of bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation.	19204468
Bronchiolitis Obliterans, Bosnian language	Stem Cell Exhaustion	To describe the high-resolution computed tomography (CT) findings occurring in bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplantation (HSCT) and to determine the relationship between pulmonary function tests (PFTs) and air trapping detected on expiratory CT.	19204468
Leukemia, Myelocytic, Acute, Cytopenia	Stem Cell Exhaustion	We performed a single center retrospective analysis of 84 autologous hemopoietic stem cell transplants done for AML to characterize the pattern of hemopoietic engraftment, post-transplant cytopenia and their impact on survival outcome.	19204715
Hodgkin Disease, Specialty Type - cancer, Neoplasms, Lymphoma	Stem Cell Exhaustion	Maybe, the recently published results of the latest researches in Hodgkin's lymphoma (evidence for the cancer stem cell; the role of T cells in tumour microenvironment in survival of lymphomas cells; the role of galectin-1 in tumor escape in Hodgkin's lymphoma) will help us to reach our therapeutic goal: cure for all patients with Hodgkin's lymphoma!	19205418
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Autologous stem cell transplantation for elderly patients with acute myeloid leukaemia conditioned with continuous infusion idarubicin and busulphan.	19206083
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Different studies have suggested the potential utility of autologous stem cell transplantation (ASCT) in acute myeloid leukaemia (AML) of the elderly with encouraging results in selected patients.	19206083
Failure	Stem Cell Exhaustion	However, while the introduction of peripheral blood stem cells (PBSC) has consistently reduced morbidity and mortality of the procedure, relapse still represents the major cause of ASCT failure.	19206083
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Intracoronary infusion of bone marrow-derived selected CD34+CXCR4+ cells and non-selected mononuclear cells in patients with acute STEMI and reduced left ventricular ejection fraction: results of randomized, multicentre Myocardial Regeneration by Intracoronary Infusion of Selected Population of Stem Cells in Acute Myocardial Infarction (REGENT) Trial.	19208649
Systemic Scleroderma	Stem Cell Exhaustion	Pregnancy and childbirth after treatment with autologous hematopoietic stem cell transplantation for severe systemic sclerosis requiring parenteral nutrition.	19210885
Sample Size Calculation	Stem Cell Exhaustion	We report a pregnancy in a patient who had undergone autologous hematopoietic stem cell transplantation (AHSCT) for diffuse cutaneous systemic sclerosis (SSc).	19210885
Hematologic Neoplasms	Stem Cell Exhaustion	Haploidentical stem cell transplantation after a reduced-intensity conditioning regimen for the treatment of advanced hematologic malignancies: posttransplantation CD8-depleted donor lymphocyte infusions contribute to improve T-cell recovery.	19211934
Hematologic Neoplasms	Stem Cell Exhaustion	Haploidentical hematopoietic stem cell transplantation provides an option for patients with advanced hematologic malignancies lacking a compatible donor.	19211934
Renal Cell Carcinoma	Stem Cell Exhaustion	We investigated the behavior of CECs in parallel with hematopoietic progenitor cells (HPCs) in the blood of renal cell cancer patients during sunitinib treatment.	19212818
Myeloid Stem Cell, Thrombocythemia, Essential	Stem Cell Exhaustion	Essential thrombocythemia (ET) is a clonal disorder of the myeloid stem cell that causes abnormal proliferation of the megakaryocytes.	19215011
Degenerative polyarthritis, Osteoporosis	Stem Cell Exhaustion	Osteogenic potential and responsiveness to leptin of mesenchymal stem cells between postmenopausal women with osteoarthritis and osteoporosis.	19215023
Degenerative polyarthritis, Osteoporosis	Stem Cell Exhaustion	The aim of this study was to compare the osteogenic potential and responsiveness to leptin of mesenchymal stem cells (MSCs) from bone marrow between postmenopausal women with osteoarthritis (OA) and osteoporosis (OP).	19215023
Coronary heart disease	Stem Cell Exhaustion	Hepatocyte growth factor plays a critical role in the regulation of cytokine production and induction of endothelial progenitor cell mobilization: a pilot gene therapy study in patients with coronary heart disease.	19215239
Coronary heart disease	Stem Cell Exhaustion	In conclusion, HGF gene therapy may play an important role in the regulation of cytokines and the induction of endothelial progenitor cell mobilization in patients with coronary heart disease.	19215239
Malignant Meningioma, Neoplasms, Astrocytoma	Stem Cell Exhaustion	Possible involvement of brain tumour stem cells in the emergence of a fast-growing malignant meningioma after surgical resection and radiotherapy of high-grade astrocytoma: case report and preliminary laboratory investigation.	19215696
Neoplasms, Astrocytoma	Stem Cell Exhaustion	A rare fraction of brain tumour stem cells (BTSC) was isolated from the primary astrocytoma using a serum-free culture system, suggesting that BTSC may have been involved in the rapid emergence of RIM after resection and radiation of the primary astrocytoma.	19215696
Pancytopenia	Stem Cell Exhaustion	Advances in HCT, such as the use of stem cells isolated from peripheral blood instead of bone marrow, have resulted in more rapid engraftment and thus a shorter duration of pancytopenia.	19217013
Cytogenetic Complete Response	Stem Cell Exhaustion	Field cancerization by modified stem cells may be the earliest changes associated with CRC.	19220296
Gastrointestinal mucositis	Stem Cell Exhaustion	Palifermin is a recombinant human keratinocyte growth factor that is used to reduce the duration and severity of oral mucositis in patients undergoing hematopoietic stem cell transplantation after myelotoxic therapy.	19221263
Erythema	Stem Cell Exhaustion	After receiving palifermin following autologous hematopoietic stem cell transplantation and treatment with melphalan, a patient developed erythema and lichenoid papules that were distributed primarily in intertriginous areas.	19221263
Kidney Diseases	Stem Cell Exhaustion	Rituximab in post allogeneic hematopoietic stem cell transplantation membranous nephropathy: a case report.	19229832
Kidney Diseases	Stem Cell Exhaustion	Membranous nephropathy (MN) post allogeneic hematopoietic stem cell transplantation (HSCT) is a rare complication with few long-term outcome data.	19229832
Lymphoma, Non-Hodgkin, Multiple Myeloma	Stem Cell Exhaustion	Peripheral blood progenitor cell collection without close monitoring of peripheral blood CD34+ cells: A feasible strategy for multiple myeloma or pre-treated Non-Hodgkin's Lymphoma patients mobilized with low-dose cyclophosphamide plus G-CSF.	19233728
Hematologic Neoplasms	Stem Cell Exhaustion	Daily monitoring of peripheral blood CD34+ cells may not be necessary for all patients with hematologic malignancies for adequate peripheral blood progenitor cells (PBPC) mobilization and harvesting.	19233728
Peripheral T-Cell Lymphoma, B-Cell Lymphomas	Stem Cell Exhaustion	Comparison of clinical outcome after autologous stem cell transplantation between patients with peripheral T-cell lymphomas and diffuse large B-cell lymphoma.	19234508
Peripheral T-Cell Lymphoma, Lymphoma, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Although patients with T-cell phenotype lymphomas are generally accepted to have worse prognosis than B-cell phenotype lymphomas, the studies comparing outcomes after autologous stem cell transplantation (ASCT) between peripheral T-cell lymphomas (PTCLs) and with diffuse large B-cell lymphoma (DLBCL) are few.	19234508
Restenosis	Stem Cell Exhaustion	The plasma levels of osteonectin-positive progenitor cells, neutrophils, and basophils did not differ in patients with and without restenosis.	19234576
Acute leukemia	Stem Cell Exhaustion	Low-dose azacitidine after allogeneic stem cell transplantation for acute leukemia.	19235255
Pathologic Neovascularization, Diabetes, Ischemia, diabetic	Stem Cell Exhaustion	Complications impaired endothelial progenitor cell function in Type 2 diabetic patients with or without critical leg ischaemia: implication for impaired neovascularization in diabetes.	19236615
Ischemia	Stem Cell Exhaustion	This study tested the hypothesis that migratory function of endothelial progenitor cells (EPCs) is impaired in Type 2 diabetic patients with or without critical leg ischaemia.	19236615
Cardiovascular Diseases	Stem Cell Exhaustion	Circulating progenitor cells such as CD34+ cells play a key role in maintenance of vascular endothelial function and neovascularization, and a decrease in the number of CD34+ cells is associated with cardiovascular disease.	19236621
Diabetic Nephropathy, Microvascular Angina	Stem Cell Exhaustion	However, the contribution of circulating progenitor cells to microvascular disease, such as diabetic nephropathy, is unclear.	19236621
Refractory cytopenia with multilineage dysplasia, Cytopenia, Refractory anemia with excess blasts II	Stem Cell Exhaustion	CD13 in RAEB-II was significantly higher than that in refractory cytopenia with or without multilineage dysplasia (RA/RCMD) (p < 0.01) and REAB-I (p < 0.05); CD33, CD117 (p < 0.05) and stem cell antigen CD34 (p < 0.01) in RAEB-II were significantly higher than that in RCMD (p < 0.01), but no statistically significant difference was found as compared with RAEB-I (p > 0.05).	19236759
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	It is concluded that standard-dose of idarubicin combined with continuous infusions of cytarabine as the induction therapy is highly effective and well tolerated approach in patients with AML, this regimen provides an opportune moment for hematopoietic stem cell transplantation.	19236781
Small cell carcinoma of lung	Stem Cell Exhaustion	High VEGFR-3-positive circulating lymphatic/vascular endothelial progenitor cell level is associated with poor prognosis in human small cell lung cancer.	19240177
Neoplasms	Stem Cell Exhaustion	The newly identified bone marrow-derived cell population, called lymphatic/vascular endothelial progenitor cells (LVEPC), has been shown to contribute to lymph capillary growth in experimental tumor systems.	19240177
Peripheral Stem Cell Transplantation, Pneumonia, Interstitial	Stem Cell Exhaustion	Nonspecific interstitial pneumonia after peripheral blood stem cell transplantation in an 11-year-old boy.	19242308
Pulmonary Complication, Opportunistic Infections, Pneumonia, Interstitial	Stem Cell Exhaustion	Late-onset pulmonary complications after peripheral blood stem cell transplantation include various conditions such as opportunistic infections and interstitial pneumonias.	19242308
Pneumonia, Interstitial, Infectious Lung Disorder, Acute lymphocytic leukemia	Stem Cell Exhaustion	We present a case of an 11-year-old boy who consecutively developed pulmonary infection and cellular nonspecific interstitial pneumonia 9 months after peripheral blood stem cell transplantation for recurrent acute lymphocytic leukemia.	19242308
Corneal stromal opacities	Stem Cell Exhaustion	To report the usefulness of the Boston type I keratoprosthesis (Massachusetts Eye and Ear Infirmary, Boston, MA) in the management of corneal opacification, corneal limbal stem cell failure, or both in a large single-surgeon series.	19243830
Visual Impairment, Corneal stromal opacities, Corneal graft failure	Stem Cell Exhaustion	The Boston type I keratoprosthesis is an effective means of managing repeat corneal graft failure and corneal limbal stem cell failure with or without corneal opacification in patients with both unilateral and bilateral visual impairment.	19243830
Philadelphia chromosome positive chronic myelogenous leukemia, BCR gene, Acute lymphocytic leukemia	Stem Cell Exhaustion	Prospective data on the value of allogeneic hematopoietic stem cell transplantation (alloHSCT) in Philadelphia chromosome-positive (Ph(+)) acute lymphoblastic leukemia (ALL) are limited.	19244158
Cerebrovascular accident	Stem Cell Exhaustion	Clinical evidence that very small embryonic-like stem cells are mobilized into peripheral blood in patients after stroke.	19246697
Cerebrovascular accident	Stem Cell Exhaustion	In a murine model of stroke, we identified a population of very small embryonic-like (VSEL) stem cells (SCs) in adult murine bone marrow that could be mobilized into peripheral blood (PB).	19246697
ST segment elevation myocardial infarction	Stem Cell Exhaustion	Consecutive patients with ST-segment elevation myocardial infarction and primary percutaneous coronary intervention were enrolled (n = 204) and randomly assigned to either stem cell therapy (bone marrow-derived progenitor cells [BMC]) or placebo after bone marrow aspiration.	19249426
Electrocardiogram: myocardial infarction (finding), Infarction	Stem Cell Exhaustion	Intracoronary administration of bone marrow-derived progenitor cells improves left ventricular function in patients at risk for adverse remodeling after acute ST-segment elevation myocardial infarction: results of the Reinfusion of Enriched Progenitor cells And Infarct Remodeling in Acute Myocardial Infarction study (REPAIR-AMI) cardiac magnetic resonance imaging substudy.	19249426
Infarction	Stem Cell Exhaustion	The cardiac CMR substudy of the randomized multicenter REPAIR-AMI trial (Reinfusion of Enriched Progenitor cells And Infarct Remodeling in Acute Myocardial Infarction study) aimed at gaining insight into postinfarction left ventricular remodeling processes.	19249426
DPM1 gene, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We raise the problem of a CML developing on an initial IMF, or two MPDs occurring from a common or two different stem cells.	19250672
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	To evaluate the patterns and timing of initial recurrence in patients with Hodgkin's lymphoma (HL) who subsequently underwent high-dose chemotherapy with autologous stem cell transplantation to enhance our understanding of the natural history of this disease and its modern treatment strategies and to direct approaches to disease surveillance.	19250770
Hypotension, CTCAE	Stem Cell Exhaustion	Peripheral blood stem cell recovery following early termination of apheresis due to hypotension in a 4.8-kg infant.	19253358
Hypotension, CTCAE	Stem Cell Exhaustion	We report a case in which peripheral blood stem cells (PBSC) were successfully recovered following early termination of a collection procedure due to hypotension in a 7-month-old patient.	19253358
Malignant neoplasm of ovary	Stem Cell Exhaustion	We report that human ovarian cancer is frequently associated with cells expressing the stem cell surface marker CD133.	19253934
Neoplasms, Krukenberg Tumor	Stem Cell Exhaustion	CD133-expressing stem cells associated with ovarian metastases establish an endothelial hierarchy and contribute to tumor vasculature.	19253934
Specialty Type - cancer	Stem Cell Exhaustion	This cell population is attracted by cancer stem cells (CSCs) and retains a direct physical association within the CSC-derived spheroids.	19253934
Neoplasms	Stem Cell Exhaustion	Our study further delineates the contribution of these vasculogenic CD133(+) stem cells, termed by us as endothelial stem cells (EnSCs) to the developing tumor vasculature during disease progression.	19253934
Heart failure	Stem Cell Exhaustion	These findings suggest that appositional growth of initial lymphatics, rather than "de novo" genesis from pluripotent stem cells or sprouting from preexisting venous vessels, may be the predominant mechanism of lymphangiogenesis in terminal heart failure.	19254175
Infections, Hospital, Virus Diseases, Community-Acquired Infections, Communicable Diseases	Stem Cell Exhaustion	Descriptive outbreak investigation of 2 hematopoietic stem cell transplant recipients and an elderly patient who developed hospital-acquired influenza A virus infection following exposure to an index patient with community-acquired H274Y-mutated influenza A(H1N1) virus infection in a medical ward at a Dutch university hospital in February 2008.	19255111
Cerebral Infarction	Stem Cell Exhaustion	[Influences of bFGF and EGF on the proliferation and differentiation of endogenous neural stem cells after cerebral infarction in human].	19257964
Cerebral Infarction	Stem Cell Exhaustion	To investigate the relationship of basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) and proliferation of endogenous neural stem cells (NSCs) after human cerebral infarction.	19257964
Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease transiently impairs thymic output in young patients after allogeneic hematopoietic stem cell transplantation.	19258596
Graft-vs-Host Disease	Stem Cell Exhaustion	Long-term T-cell reconstitution after hematopoietic stem cell transplantation (HSCT) is dependent on patient thymic function and affected by graft-versus-host disease (GVHD).	19258596
Rhabdoid Tumor	Stem Cell Exhaustion	Long-term survival after autologous peripheral blood stem cell transplantation in two patients with malignant rhabdoid tumor of the kidney.	19260106
Rhabdoid Tumor, Neoplasms	Stem Cell Exhaustion	A 5-month-old male with stage II malignant rhabdoid tumor of the kidney (MRTK) and a 24-month-old male with stage III MRTK were treated with surgical resection of tumors and chemotherapy of alternating ICE (ifosfamide, carboplatin, and etoposide) and VDC (vincristine, doxorubicin, and cyclophosphamide), followed by high-dose chemotherapy using etoposide, carboplatin, and melphalan with autologous hematopoietic stem cell transplantation (SCT).	19260106
Specialty Type - cancer	Stem Cell Exhaustion	TGF-beta1 may sensitize cancer stem cells to chemoradiotherapy.	19260117
Colorectal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers.	19261858
Specialty Type - cancer	Stem Cell Exhaustion	Methylation patterns were too diverse to be consistent with very rare cancer stem cells but were more consistent with multiple ( approximately 4 to 1,000) long-lived cancer stem cell lineages per cancer gland.	19261858
Acute Cerebrovascular Accidents	Stem Cell Exhaustion	Circulating endothelial progenitor cells in Chinese patients with acute stroke.	19262489
Acute cerebrovascular disease, Acute Cerebrovascular Accidents	Stem Cell Exhaustion	To test the hypothesis that a mobilization of endothelial progenitor cells (EPCs) occurs after acute cerebrovascular diseases, we evaluated the number of EPCs in the process of acute stroke.	19262489
Hematological Disease	Stem Cell Exhaustion	We compared a single, subcutaneous fixed dose of 6 mg pegfilgrastim on day +5 with daily lenograstim 263 microg from day +5 and continued until neutrophils were >or=0.5 x 10(9)/L after allogeneic peripheral blood stem-cell transplantation (PBSCT) from unrelated donors for various hematological disorders.	19263295
Prostate carcinoma	Stem Cell Exhaustion	CD90 is a marker of mesenchymal stem cells (MSCs) and its expression is higher in prostate cancer stroma compared to normal tissue.	19267366
Primary immune deficiency disorder, Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	Three forms exist; GS type 2 (GS2), the most common one, is characterized by severe primary immunodeficiency with acute episodes of hemophagocytic lymphohistiocytosis (HLH) which may be fatal in the absence of hematopoietic stem cell transplantation.	19270433
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	GEPD chemotherapy in patients with refractory or relapsed NHL was effective as a salvage therapy and helpful for stem cell harvest followed by autologous transplantation.	19270480
Multiple Myeloma	Stem Cell Exhaustion	Consolidation therapy with low-dose thalidomide and prednisolone prolongs the survival of multiple myeloma patients undergoing a single autologous stem-cell transplantation procedure.	19273705
44289	Stem Cell Exhaustion	The malignant and benign prostate cells, which are immunopositive for variant 2 of Oct 3/4, lack other stem cell markers supporting previously published data that variant 2 of Oct 3/4 is not a pluripotency marker.	19274762
Hypersensitivity	Stem Cell Exhaustion	A hematopoietic stem cell transplant patient with a history of immediate drug hypersensitivity reaction to micafungin was considered for a caspofungin trial.	19276144
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	GENAMI, an angiographic follow-up study was undertaken to evaluate the safety and efficacy of a new generation endothelial progenitor cell (EPC) capture stent, GENOUS during primary angioplasty for ST-elevation myocardial infarction (MI).	19276491
disease stage	Stem Cell Exhaustion	Distinct recommendations were produced for initial work-up, first-line therapy of early and advanced stage disease, monitoring procedures and salvage therapy, including hemopoietic stem cell transplant.	19278966
Relapsing course	Stem Cell Exhaustion	Relapsed or refractory patients should receive high-dose chemotherapy and autologous hemopoietic stem cells transplant.	19278966
Therapy-related myelodysplastic syndrome, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Risk factors for therapy-related myelodysplastic syndrome and acute myeloid leukemia treated with allogeneic stem cell transplantation.	19278968
Therapy-related myelodysplastic syndrome, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The aim of this study was to investigate outcome and risk factors in patients with therapy-related myelodysplastic syndrome or acute myeloid leukemia who underwent allogeneic stem cell transplantation.	19278968
Hematological Disease, Lymphoma, Myeloid, Therapy-related myelodysplastic syndrome, Neoplasms	Stem Cell Exhaustion	Between 1981 and 2006, 461 patients with therapy-related myelodysplastic syndrome or acute myeloid, a median age of 40 years and a history of solid tumor (n=163), malignant lymphoma (n=133), or other hematologic diseases (n=57) underwent stem cell transplantation and their data were reported to the European Group for Blood and Marrow Transplantation.	19278968
Therapy-related myelodysplastic syndrome, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic stem cell transplantation can cure patients with therapy-related myelodysplastic syndrome and acute myeloid leukemia and has markedly improved over time.	19278968
Multiple Myeloma	Stem Cell Exhaustion	Complete remission status before autologous stem cell transplantation is an important prognostic factor in patients with multiple myeloma undergoing upfront single autologous transplantation.	19285634
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Upfront high-dose myeloablative chemotherapy followed by a single autologous stem cell transplantation (ASCT) is the standard therapy for patients under the age of 65 years with newly diagnosed multiple myeloma (MM).	19285634
Peripheral Blood Stem Cells	Stem Cell Exhaustion	All patients received peripheral blood stem cell (PBSC) support after conditioning with melphalan (Mel) alone.	19285634
Peripheral Blood Eosinophilia	Stem Cell Exhaustion	Peripheral blood eosinophilia has a favorable prognostic impact on transplant outcomes after allogeneic peripheral blood stem cell transplantation.	19285635
Eosinophil count raised (finding)	Stem Cell Exhaustion	Peripheral eosinophilia after allogeneic stem cell transplant (ASCT) may reflect the activation of the Th2 cytokine pathway.	19285635
Febrile Neutropenia	Stem Cell Exhaustion	We analyzed the efficacy of imipenem/cilastatin alone (group I, 197 patients) or in combination with a glycopeptide (group I + G, 231 patients) as first-line antibiotic therapy for 2 consecutive cohorts of autologous stem cell transplantation (ASCT) recipients with febrile neutropenia.	19285640
Bacteremia	Stem Cell Exhaustion	Factors associated with bacteremia due to multidrug-resistant Gram-negative bacilli in hematopoietic stem cell transplant recipients.	19287908
Bacteremia	Stem Cell Exhaustion	We conducted a case-control study in order to identify factors associated with bacteremia due to multidrug-resistant Gram-negative (MDRGN) isolates in hematopoietic stem cell transplant recipients.	19287908
Communicable Diseases	Stem Cell Exhaustion	Infection due to MDRGN bacteria occurred in 2.9% of 342 hematopoietic stem cell transplant recipients.	19287908
Hodgkin Disease	Stem Cell Exhaustion	Bone marrow stem cell damage after three different chemotherapy regimens for advanced Hodgkin's lymphoma.	19288005
Childhood Ependymoma	Stem Cell Exhaustion	Furthermore, inhibition of Notch pathway with a gamma-secretase inhibitor impaired the growth of ependymoma stem cell cultures.	19289631
Bone necrosis	Stem Cell Exhaustion	The altered function of mesenchymal stem cells may be responsible for the pathogenesis and progression of osteonecrosis.	19292322
Immunologic Deficiency Syndromes	Stem Cell Exhaustion	The development of EBV-LPD has been associated with the use of immunosuppressive agents used in solid organ, bone marrow, and stem cell transplantation and in certain congenital immunodeficiencies.	19293260
Tumors of Adrenal Cortex	Stem Cell Exhaustion	We conclude that our findings provide further evidence that nestin, as a marker, is not restricted to neuronal stem cells and nestin expression is worth to be studied in adrenocortical tumors.	19294612
Lupus Erythematosus	Stem Cell Exhaustion	Expression of hair follicle stem cells detected by cytokeratin 15 stain: implications for pathogenesis of the scarring process in cutaneous lupus erythematosus.	19298282
Lupus Erythematosus, Discoid, Inflammation	Stem Cell Exhaustion	The fact that inflammation in DLE generally involves the bulge area of the follicles raises the possibility that damage to the stem cells of the bulge region may be one process leading to the permanent loss of follicles.	19298282
Lupus Erythematosus	Stem Cell Exhaustion	The aim of this study was to investigate the role of the hair follicle stem cells which reside in the bulge region in the scarring process in cutaneous lupus erythematosus (CLE).	19298282
Hair follicle structure	Stem Cell Exhaustion	We studied the reactivity of an antibody to the CD8 antigen (C8/144B), which recognizes cytokeratin (CK) 15 and preferentially immunostains hair follicle stem cells without staining the remaining hair follicle, on skin biopsies (scalp and body lesions) from patients with CLE (36 with discoid lesions and 10 with subacute lesions).	19298282
Inflammation	Stem Cell Exhaustion	The expression of CK15 in hair follicle stem cells was variable in the DLE lesions; there was normal to moderate CK15 expression at the bulge region of hair follicles when surrounded by mild or moderate inflammatory infiltrate (CD8+), but in cases of severe inflammation, CK15 expression was weak or absent.	19298282
Alopecia	Stem Cell Exhaustion	Damage to follicular stem cells may help to explain the irreversible alopecia and the scarring process which characterize this disease.	19298282
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myeloid leukemia (CML) is a clonal disorder of the stem cells which has impaired cell-mediated immune response.	19298721
Acute leukemia	Stem Cell Exhaustion	Outcome of HLA-matched related allogeneic hematopoietic stem cell transplantation for patients with acute leukemia in first complete remission treated in Eastern European centers.	19301005
Acute leukemia	Stem Cell Exhaustion	The goal of this study was to analyze results and to determine factors affecting outcome of HLA-matched hematopoetic stem cells transplantation (MRD-HSCT) for patients with acute leukemia transplanted in first complete remission in Eastern European countries.	19301005
Hematologic Neoplasms, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Fifteen patients received therapy for acute myeloid leukaemia and 27 patients received autologous stem cell transplantation for haematological malignancy.	19302556
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Combined inhibition of integrin linked kinase and FMS-like tyrosine kinase 3 is cytotoxic to acute myeloid leukemia progenitor cells.	19302919
Myocardial Ischemia	Stem Cell Exhaustion	Progenitor cells (PC) are thought to induce angiogenesis, and thereby, PC may help to improve ventricular performance in patients with ischemic heart disease (IHD).	19303649
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Reduced intensity versus full myeloablative stem cell transplant for advanced CLL.	19308041
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	[Effect of yiqi wenyang huoxue recipe on bone marrow stem cells' mobilization and its influence on heart function in patients with myocardial infarction].	19317161
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	To observe the effect of Yiqi Wenyang Huoxue Recipe (YWHR) on bone marrow stem cells' mobilization and heart function of myocardial infarction (MI) patients.	19317161
Usual Severity Pain	Stem Cell Exhaustion	Cyclosporine-induced pain syndrome in a child undergoing hematopoietic stem cell transplant.	19318596
melanoma	Stem Cell Exhaustion	The transformation of normal melanocytes, or melanocyte stem cells, to melanoma, is a complex process involving multiple mechanisms.	19318806
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The changing scene of allogeneic stem cell transplantation for chronic myeloid leukemia--a report from the German Registry covering the period from 1998 to 2004.	19319532
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Due to the recent changes in the indication to allogeneic stem cell transplantation (SCT) in chronic myeloid leukemia (CML), we retrospectively analyzed 1,716 patients with different CML stages who received an allograft from related (n = 767) or unrelated donors (n = 938) within the German Registry of Stem Cell Transplantation (DRST) from 1998 to 2004.	19319532
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	High CD4/CD8 ratio in allografts predicts adverse outcomes in unmanipulated HLA-mismatched/haploidentical hematopoietic stem cell transplantation for chronic myeloid leukemia.	19319533
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	HLA-mismatched/haploidentical hematopoietic stem cell transplantation (haplo-mismatched HSCT) has improved the outcome of chronic myeloid leukemia (CML) in patients without an HLA-matched donor.	19319533
Antilymphocyte Serum	Stem Cell Exhaustion	Growth factor-expressing human neural progenitor cell grafts protect motor neurons but do not ameliorate motor performance and survival in ALS mice.	19322031
nervous system disorder	Stem Cell Exhaustion	Neural progenitor cells (NPs) have shown several promising benefits for the treatment of neurological disorders.	19322031
Amyotrophic Lateral Sclerosis, Antilymphocyte Serum	Stem Cell Exhaustion	To evaluate the therapeutic potential of human neural progenitor cells (hNPs) in amyotrophic lateral sclerosis (ALS), we transplanted hNPs or growth factor (GF)-expressing hNPs into the central nervous system (CNS) of mutant Cu/Zn superoxide dismutase (SOD1(G93A)) transgenic mice.	19322031
Peripheral Stem Cell Transplantation, Multiple Myeloma	Stem Cell Exhaustion	A 54-year-old man with multiple myeloma underwent peripheral blood stem cell transplantation (PBSCT) with cells donated by his human leukocyte antigen (HLA)-identical sister.	19322189
Usual Severity Pain, Paraplegia	Stem Cell Exhaustion	A 46-year-old woman with IgA-lambda myeloma in partial remission, after a tandem autologous hematopoietic stem cells transplantation, complained of progressive lower back pain associated with paraplegia and neurological bladder 6 months after the second transplant.	19322629
Acute GVH disease, Necrosis	Stem Cell Exhaustion	Although anti-tumor necrosis factor alpha therapy has been widely used for the treatment of steroid-resistant acute graft-versus-host disease in the hematopoietic stem cell transplant setting, there previously have been no reported cases of its use in liver transplantation.	19326415
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is a clonal disorder of pluripotential stem cells of the bone marrow.	19332914
Acute myocardial infarction	Stem Cell Exhaustion	Percutaneous intramyocardial stem cell injection in patients with acute myocardial infarction: first-in-man study.	19336430
Acute myocardial infarction	Stem Cell Exhaustion	Clinical studies on intracoronary stem cell infusion in patients with acute myocardial infarction (AMI) have shown promising results for left ventricular ejection fraction (LVEF).	19336430
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	The hematopoietic stem cell transplantation comorbidity index is of prognostic relevance for patients with myelodysplastic syndrome.	19336740
Comorbidity, PAFAH1B1 wt Allele	Stem Cell Exhaustion	We studied the impact of comorbidities on survival and evaluated the prognostic utility of comorbidity scores in MDS patients, who received best supportive care and were assessable according to the Charlson Comorbidity Index (CCI) and the Hematopoietic Stem Cell Transplantation Comorbidity Index (HCTCI): 171 patients were identified in the Duesseldorf MDS Registry.	19336740
Ceramide Nanoliposome	Stem Cell Exhaustion	Although the prognosis of CNL was not determined, curative therapy including allogeneic hematopoietic stem cell transplantation should be attempted in young patients with CNL.	19336960
Intracranial Hemorrhage	Stem Cell Exhaustion	Intracranial hemorrhage following allogeneic hematopoietic stem cell transplantation.	19338041
COL4A2 wt Allele, Intracranial Hemorrhage	Stem Cell Exhaustion	Charts and radiographs of 622 allogeneic hematopoietic stem cell transplant (HSCT) recipients, over a 20-year period, were retrospectively reviewed for intracranial hemorrhage (ICH) following transplant.	19338041
Multiple Myeloma	Stem Cell Exhaustion	Combinations of cytogenetics and international scoring system can predict poor prognosis in multiple myeloma after high-dose chemotherapy and autologous stem cell transplantation.	19338045
Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is a standard therapy for newly diagnosed multiple myeloma.	19338045
Degenerative polyarthritis	Stem Cell Exhaustion	We show that repair tissue from human articular cartilage during the late stages of osteoarthritis harbors a unique progenitor cell population, termed chondrogenic progenitor cells (CPCs).	19341622
Degenerative polyarthritis	Stem Cell Exhaustion	Migratory chondrogenic progenitor cells from repair tissue during the later stages of human osteoarthritis.	19341622
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Consolidation with stem cell transplantation was used in 14 patients with aggressive lymphoma and 4 with indolent lymphoma; 14 patients, all with aggressive lymphoma, responded (12 complete, 2 partial).	19344007
Hemorrhagic cystitis	Stem Cell Exhaustion	Late onset hemorrhagic cystitis in a hematopoietic stem cell recipient: treatment with intravesical hyaluronic acid.	19344339
B-Cell Lymphomas, Acute GVH disease	Stem Cell Exhaustion	Prior rituximab correlates with less acute graft-versus-host disease and better survival in B-cell lymphoma patients who received allogeneic peripheral blood stem cell transplantation.	19344418
leukemia	Stem Cell Exhaustion	Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study.	19345145
leukemia	Stem Cell Exhaustion	From Aug 13, 2002, to March 26, 2008, 50 patients (median age 51 years, range 17-66) received haploidentical stem-cell transplants for high-risk leukaemia.	19345145
leukemia	Stem Cell Exhaustion	Overall survival at 3 years was 49% (95% CI 25-73) for 19 patients who were in remission from primary leukaemia at the time of stem-cell transplantation.	19345145
Graft-vs-Host Disease	Stem Cell Exhaustion	Infusion of TK-cells might be effective in accelerating immune reconstitution, while controlling GVHD and protecting patients from late mortality in those who are candidates for haploidentical stem-cell transplantation.	19345145
Graft-vs-Host Disease, leukemia, Aspects of mortality statistics	Stem Cell Exhaustion	Procedures to prevent severe graft-versus-host disease (GVHD) delay immune reconstitution secondary to transplants of haploidentical haemopoietic stem cells for the treatment of leukaemia, leading to high rates of late infectious mortality.	19345145
Inflammation, Rheumatoid Factor	Stem Cell Exhaustion	Mesenchymal stem cells in rheumatoid synovium: enumeration and functional assessment in relation to synovial inflammation level.	19346219
Lymphoma, Non-Hodgkin, Familial, Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation (AHCT) for relapsed/refractory aggressive non-Hodgkin lymphoma (NHL) results in long-term disease-free survival in 40-50% of patients.	19347727
Multiple Myeloma	Stem Cell Exhaustion	A simplified method for stem cell autografting in multiple myeloma: a single institution experience.	19349952
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	In a 14-year period in a single institution 31 autografts were performed in 26 patients with multiple myeloma (MM), using a simplified and affordable autografting procedure: conducting the grafts on an outpatient basis and avoiding stem cell freezing.	19349952
Gastrointestinal mucositis	Stem Cell Exhaustion	Characteristics and risk factors of oral mucositis after allogeneic stem cell transplantation with FLU/MEL conditioning regimen in context with BU/CY2.	19349956
Malignant Neoplasms	Stem Cell Exhaustion	Identification of gliotropic factors that induce human stem cell migration to malignant tumor.	19351187
Glioblastoma Multiforme Pathway, Brain Injuries	Stem Cell Exhaustion	Neural stem cells are mobile, are attracted to regions of brain damage, and can migrate a considerable distance to reach a glioma site.	19351187
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	This research is expected to provide clues to the molecular mechanisms underlying the migration of neural stem cells (F3 cell) to glioma sites.	19351187
Neoplasms	Stem Cell Exhaustion	Furthermore, this study suggests that the ability to propagate brain tumor stem cells in vitro is associated with clinical outcome.	19353526
Mammary Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	Tumourigenic subpopulations with stem cell-like features have been identified in breast tumours and breast cancer cell lines.	19353633
Cerebral Small Vessel Diseases	Stem Cell Exhaustion	Haptoglobin phenotype may alter endothelial progenitor cell cluster formation in cerebral small vessel disease.	19355924
Multiple Myeloma	Stem Cell Exhaustion	Mesenchymal stem cells from multiple myeloma patients display distinct genomic profile as compared with those from normal donors.	19357701
Multiple Myeloma	Stem Cell Exhaustion	We conducted an array-based comparative genomic hybridization (array-CGH) analysis to compare the extent of unbalanced genomic alterations in mesenchymal stem cells from 21 myeloma patients (MM-MSCs) and 12 normal donors (ND-MSCs) after in vitro culture expansion.	19357701
Toxic effect	Stem Cell Exhaustion	Secondary endpoints were to assess the toxicity of the regimen and to evaluate the ability of patients to proceed to stem cell transplant (SCT).	19358012
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Telomerase activity seems to be required in essentially all tumours for the immortalization of a subset of cells, including cancer stem cells.	19358275
Endothelial dysfunction	Stem Cell Exhaustion	This study evaluated the relative impact of the intensity of the conditioning regimen and the alloreactivity in the endothelial dysfunction occurring after allogeneic hematopoietic stem cell transplantation (allo-HSCT).	19361745
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	We conducted a phase II trial to investigate the safety and efficacy of alemtuzumab in treating steroid-refractory acute graft-versus-host disease (aGVHD) grade II or higher after stem cell transplantation.	19361757
Graft-vs-Host Disease	Stem Cell Exhaustion	Early recognition of gastrointestinal graft-versus-host disease (GI GVHD) after allogeneic hematopoietic stem cell transplantation (alloHSCT) is vital to initiation of therapy.	19361758
Multiple Myeloma	Stem Cell Exhaustion	Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma.	19363221
Multiple Myeloma	Stem Cell Exhaustion	This phase 3, multicenter, randomized (1:1), double-blind, placebo-controlled study evaluated the safety and efficacy of plerixafor with granulocyte colony-stimulating factor (G-CSF) in mobilizing hematopoietic stem cells in patients with multiple myeloma.	19363221
Coronary Arteriosclerosis, Impaired T cell function	Stem Cell Exhaustion	Role of extracellular signal-regulated kinase for endothelial progenitor cell dysfunction in coronary artery disease.	19363666
Coronary Arteriosclerosis	Stem Cell Exhaustion	In patients with coronary artery disease (CAD), number and function of endothelial progenitor cells (EPCs) are down-regulated.	19363666
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Prolonged survival of patients with peripheral T-cell lymphoma after first-line intensive sequential chemotherapy with autologous stem cell transplantation.	19365529
Diabetes Mellitus, Insulin-Dependent	Stem Cell Exhaustion	C-peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus.	19366777
Diabetes Mellitus, Insulin-Dependent, Dominica	Stem Cell Exhaustion	In 2007, the effects of the autologous nonmyeloablative hematopoietic stem cell transplantation (HSCT) in 15 patients with type 1 diabetes mellitus (DM) were reported.	19366777
insulinoma	Stem Cell Exhaustion	To investigate if this effect was due to preservation of beta-cell mass, continued monitoring was performed of C-peptide levels after stem cell transplantation in the 15 original and 8 additional patients.	19366777
Necrosis, HIV	Stem Cell Exhaustion	We conducted a prospective, randomized study to compare the humoral response upon standard intramuscular influenza vaccination with the response upon reduced-dose intradermal vaccination in patients treated with anti-tumor necrosis factor (TNF)-alpha, human immunodeficiency virus (HIV)-infected patients, hematologic stem cell transplantation (HSCT) patients, and healthy controls.	19368788
Pterygium	Stem Cell Exhaustion	The position or the presence of stem cells of the corneal epithelium is not important in the outcome of the pterygium surgery.	19370279
Coronary Arteriosclerosis	Stem Cell Exhaustion	Effect of atorvastatin on microRNA 221 / 222 expression in endothelial progenitor cells obtained from patients with coronary artery disease.	19371267
Acute myocardial infarction	Stem Cell Exhaustion	Role of stromal cell-derived factor-1alpha, level and value of circulating interleukin-10 and endothelial progenitor cells in patients with acute myocardial infarction undergoing primary coronary angioplasty.	19372622
ST segment elevation myocardial infarction	Stem Cell Exhaustion	The relationships among the circulating levels of endothelial progenitor cells (EPC), stromal cell-derived factor (SDF)-1alpha, interleukin (IL)-10 and outcome were examined in patients with ST-segment elevation acute myocardial infarction (ST-se AMI) undergoing primary coronary angioplasty.	19372622
Mitochondrial Damage, Specialty Type - cancer	Stem Cell Exhaustion	This was followed by a series of presentations on cell biology (Judith Campisi), evolutionary biology (Steven N. Austad), mitochondrial damage (Lawrence A. Loeb), stem cell functionality (Thomas A. Rando), oxidative stress and cancer resistance (Rochelle Buffenstein), signal transduction and replicative senescence in cancer and aging (Norman E. Sharpless), and telomere biology (Jack D. Griffith).	19377012
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	The graft-versus-leukemia effect is able to induce clinical responses in patients with chronic lymphocytic leukemia treated with a reduced intensity conditioning regimen, followed by allogeneic stem cell transplantation.	19377072
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	We investigated whether molecular remissions could be attained after reduced intensity conditioning and allogeneic stem cell transplantation in patients with relapsed chronic lymphocytic leukemia and whether the assessment of minimal residual disease might be used to predict the clinical outcome.	19377072
Hematologic Neoplasms	Stem Cell Exhaustion	Spontaneous CNS cell replacement compares poorly with the regenerative functional repair seen elsewhere, but harnessing, stimulating or supplementing this process represents a new and attractive therapeutic concept.Stem cells, traditionally defined as clone-forming, self-renewing, pluripotent progenitor cells, have already proved themselves to be an invaluable source of transplantation material in several clinical settings, most notably haematological malignancy, and attention is now turning to a wider variety of diseases in which there may be potential for therapeutic intervention with stem cell transplantation.	19378193
nervous system disorder	Stem Cell Exhaustion	Adult stem cells for the treatment of neurological disease.	19378193
Ischemia, Diabetic Foot	Stem Cell Exhaustion	Autologous bone marrow stem cell transplantation in patients with end-stage chronical critical limb ischemia and diabetic foot.	19378841
Ischemia	Stem Cell Exhaustion	To assess efficacy and safety of critical lower limb ischaemia treatment with marrow stem cell autotransplantation.	19378842
Ischemic	Stem Cell Exhaustion	Marrow stem cell autotransplantation into the ischaemic lower limb seems to be a potentially effective method of peripheral perfusion enhancement.	19378842
Pseudarthrosis, Fracture	Stem Cell Exhaustion	[Our first experiences with autologous transplantation of bone marrow stem cells to treat pseudarthrosis, delayed fracture healing and long bone defects fracture].	19378844
Retinal defect	Stem Cell Exhaustion	Traumatology and orthopaedics could utilise stem cells in the treatment of bone defects, i.e.	19378844
Pseudarthrosis	Stem Cell Exhaustion	A number of studies showed positive results for stem cells treatment of pseudarthrosis, with only a fraction, however, being statistically significant in human medicine.	19378844
Defect	Stem Cell Exhaustion	Autologous concentrate of bone marrow stem cells was applied in one session into the area of bone defect in a patient lightly anaesthetised with propofol.	19378844
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Herein, we present a 15-year-old acute myeloid leukemia patient who was resistant at relapse and could achieve remission with gemtuzumab ozogamicin at a total dose of 9 mg/m2, divided into three doses and delivered to hematopoietic stem-cell transplantation; however, the patient relapsed in a short time without application of transplantation.	19378895
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	CD34(+)CD38(+) progenitor cells and CD34(+)CD38(-)Lin(-) stem cells were sorted by flow cytometry (FCM) from the MNCs of 10 NBM and 21 AML BM specimen.	19379555
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	[Expression of 5 genes in CD7 positive acute myeloid leukemia stem/progenitor cells from bone marrow].	19379555
Bone Marrow, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This study was aimed to investigate abca5, mdr-1, kdr, dapk and irf-1 expressions in leukemia stem/progenitor cells (LSC) from CD7 positive acute myeloid leukemia, the expression of these 5 genes in mononuclear cells (MNC) from 15 normal bone marrow (NBM) and 16 AML patients bone marrow (AML BM) specimen were detected by real-time quantitative PCR (RQ-PCR).	19379555
Purpura, Thrombotic Thrombocytopenic	Stem Cell Exhaustion	The results showed that after one course of induction therapy, 4 patients all achieved complete remission (CR), in which 2 patients were in continuous CR after a follow-up of 3 and 4 months; 1 patient relapsed after 10 months and another one patient died of thrombotic thrombocytopenic purpura at 4 months after allogeneic peripheral blood stem cell transplantation.	19379589
Pancreatitis	Stem Cell Exhaustion	[Acute pancreatitis induced by cyclosporine a following allogeneic hematopoietic stem cell transplant].	19379591
Pancreatitis	Stem Cell Exhaustion	Pancreatitis has not been reported in allogeneic stem cell transplant (allo-SCT) recipients with cyclosporine in China.	19379591
Pancreatitis	Stem Cell Exhaustion	This article presented a case of acute pancreatitis in a 49-year-old patient with AML-M2a who received allogeneic stem cell transplant from her HLA identical sister.	19379591
Congestive heart failure	Stem Cell Exhaustion	Endothelial progenitor cells (EPC) which are characterised by the simulateous expression of CD34, CD133 and vascular endothelial growth receptor 2 (VEGF 2) are involved in the pathophysiology of congestive heart failure (CHF) and their number and function is reduced in CHF.	19380281
Congestive heart failure	Stem Cell Exhaustion	But so far our knowledge about the number of circulating hematopoietic stem/ progenitor cells (CPC) expressing the early hematopoietic marker CD133 and CD34 in CHF is spares and therefore we determined their number and correlated them with New York Heart Association (NYHA) functional class.	19380281
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	To identify risk factors for induction success and overall survival (OS) and relapse-free survival (RFS) and to evaluate the impact of allogeneic stem-cell transplantation (alloSCT) in adult patients up to 60 years old with acute myeloid leukemia (AML) and reciprocal translocations involving chromosome band 11q23 [t(11q23)].	19380453
Juvenile fibroadenoma of breast	Stem Cell Exhaustion	Cells with a very similar phenotype to the CK15+/CK19+ progenitor cells were observed in a juvenile fibroadenoma as well as in the large collecting ducts of the breast.	19383306
Specialty Type - cancer	Stem Cell Exhaustion	Further molecular characterization of these progenitor cells as well as unraveling of the signaling pathways that regulate their growth and differentiation may prove invaluable for developing novel therapeutic strategies that target cancer at an early stage.	19383306
Disorder of skeletal system	Stem Cell Exhaustion	Bone marrow stromal cell populations, containing a subset of multipotential skeletal stem cells, are increasingly contemplated for use in tissue engineering and stem cell therapy, whereas their involvement in the pathogenetic mechanisms of skeletal disorders is far less recognized.	19383412
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Epstein-Barr virus (EBV) reactivation after hematopoietic stem-cell transplantation can lead to posttransplant lymphoproliferative disease (PTLD), which carries a high mortality rate.	19384173
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Our PCR-guided and rituximab-based preemptive approach to avoid PTLD after allogeneic hematopoietic stem-cell transplantation is feasible but probably overtreated patients.	19384173
Lymphoma	Stem Cell Exhaustion	Poor hematopoietic stem cell mobilizers: a single institution study of incidence and risk factors in patients with recurrent or relapsed lymphoma.	19384931
Failure, Lymphoma	Stem Cell Exhaustion	The purpose of this retrospective study was to determine the incidence and predictive factors if any, of mobilization failure in lymphoma patients referred for autologous stem cell transplantation.	19384931
Mammary Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	The capacity for breast tumour development has been shown to be restricted to breast cancer stem cells with the CD44+/CD24(-/low) phenotype.	19385591
Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	Our findings suggest that the prevalence of CD44+ tumour cells as a subpopulation of breast cancer stem cells was of no clinicopathological significance, but was correlated with higher Bcl-2 expression.	19385591
Malignant neoplasm of breast	Stem Cell Exhaustion	Stem cell marker aldehyde dehydrogenase 1-positive breast cancers are characterized by negative estrogen receptor, positive human epidermal growth factor receptor type 2, and high Ki67 expression.	19385968
Childhood Breast Carcinoma	Stem Cell Exhaustion	Recently, aldehyde dehydrogenase (ALDH) 1 has been identified as a reliable marker for breast cancer stem cells.	19385968
Malignant neoplasm of breast, Specialty Type - cancer	Stem Cell Exhaustion	The aim of our study was to investigate the clinicopathological characteristics of breast cancers with ALDH1+ cancer stem cells.	19385968
Malignant neoplasm of breast, Specialty Type - cancer, Estrogen receptor negative	Stem Cell Exhaustion	Breast cancers with ALDH1+ cancer stem cells posses biologically aggressive phenotypes that tend to have a poor prognosis, and ALDH1+ cancer stem cells are characterized by ER-, Ki67-, and HER2+.	19385968
Neoplasms	Stem Cell Exhaustion	Recent studies suggest that vascular endothelial growth factor receptor (VEGFR) 1-positive hematopoietic progenitor cells precede the arrival of tumor cells and form clusters that may portend sites of future metastatic disease.	19385972
Coronary Arteriosclerosis	Stem Cell Exhaustion	Circulating endothelial progenitor cells in postmenopausal women with and without coronary artery disease.	19387882
Glioma	Stem Cell Exhaustion	Bmi-1 expression is elevated in most human gliomas, irrespective of grade, raising the question of whether Bmi-1 over-expression is sufficient to promote self-renewal or tumorigenesis by CNS stem/progenitor cells.	19389366
Coronary Arteriosclerosis	Stem Cell Exhaustion	Fourteen patients with diffuse coronary artery disease and medically refractory class III/IV angina who were not candidates for conventional therapies were treated using TMR in combination with intramyocardial injection of concentrated stem cells.	19394846
Angina Pectoris	Stem Cell Exhaustion	Efficient delivery of stem cells combined with TMR in a single device seems to be safe and effective for treating unmanageable angina.	19394846
Mastocytosis	Stem Cell Exhaustion	Systemic mastocytosis is a stem cell disorder characterized histologically by the presence of multifocal compact aggregates of mast cells in at least one extracutaneous organ with or without evidence of skin lesions.	19396155
PAFAH1B1 wt Allele	Stem Cell Exhaustion	This case clinically supports the nature of MDS as a pluripotent hematopoietic stem cell disorder.	19397230
Diabetes, Vascular Diseases	Stem Cell Exhaustion	Different subpopulations of endothelial progenitor cells and circulating apoptotic progenitor cells in patients with vascular disease and diabetes.	19398138
Diabetes	Stem Cell Exhaustion	CD34-/CD133+/KDR+ cells were lower, whereas staining for apoptosis in progenitor cells was higher in patients with diabetes.	19398138
Diabetes	Stem Cell Exhaustion	Higher apoptotic rates of progenitor cells in diabetes could represent an important mechanism explaining lower functional capability of these cells.	19398138
Rheumatoid Arthritis, Degenerative polyarthritis	Stem Cell Exhaustion	Equivalent osteoblastic differentiation function of human mesenchymal stem cells from rheumatoid arthritis in comparison with osteoarthritis.	19398485
Rheumatoid Arthritis	Stem Cell Exhaustion	To evaluate the osteoblastic differentiation of human mesenchymal stem cells (hMSCs) in patients with RA.	19398485
Neoplasms, Glioblastoma	Stem Cell Exhaustion	Brain tumor stem cells from an adenoid glioblastoma multiforme.	19398857
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Brain tumors may arise from and contain cancer stem cells (CSCs) capable of self-renewal, proliferation, and differentiation that recapitulate the parent tumor.	19398857
Hepatic Veno-Occlusive Disease	Stem Cell Exhaustion	Serum ferritin as risk factor for sinusoidal obstruction syndrome of the liver in patients undergoing hematopoietic stem cell transplantation.	19401560
Hepatic Veno-Occlusive Disease, Spondylo-ocular syndrome	Stem Cell Exhaustion	Hepatic sinusoidal obstruction syndrome (SOS) is a serious complication in hematopoietic stem cell transplant (HSCT) recipients.	19401560
Mouse mammary tumor virus, Malignant tumor of colon	Stem Cell Exhaustion	Nuclear beta-catenin and CD133 are linked with two hallmarks of colon cancer, wingless-type mouse mammary tumour virus integration site (WNT)-pathway dysregulation and colon cancer stem cells (Co-CSCs), respectively.	19403300
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	[Alterations of peripheral blood endothelial progenitor cells from patients with ST elevation myocardial infarction after snake venom fibrinolytic enzyme therapy].	19403409
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	To investigate the morphological and quantitative alterations of peripheral blood endothelial progenitor cells (EPCs) in patients with ST elevation myocardial infarction (STEMI) after snake venom fibrinolytic enzyme therapy.	19403409
Neoplasms	Stem Cell Exhaustion	Circulating endothelial progenitor cells are unique vascular precursors recruited from the bone marrow through the circulation to form new tumor blood vessels.	19404145
Infection of bloodstream	Stem Cell Exhaustion	Gram-negative bloodstream infections in hematopoietic stem cell transplant patients: the roles of needleless device use, bathing practices, and catheter care.	19406332
Infection of bloodstream	Stem Cell Exhaustion	Between August 1 and October 30, 1998 (outbreak period), an increased incidence of central venous catheter (CVC)-associated gram-negative bacterial bloodstream infection (GN-BSI) was detected in hematopoietic stem cell transplantation (HSCT) candidates and recipients in an outpatient HSCT unit.	19406332
Graft-vs-Host Disease	Stem Cell Exhaustion	Association of IL-10 and IL-10Rbeta gene polymorphisms with graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling donor.	19409109
Chronic graft-versus-host disease	Stem Cell Exhaustion	Cellular senescence of white blood cells in very long-term survivors after allogeneic hematopoietic stem cell transplantation: the role of chronic graft-versus-host disease and female donor sex.	19411630
Neoplasms, Squamous cell carcinoma of esophagus	Stem Cell Exhaustion	Since the function of pluripotency and self-renewal of these factors has been characterized in human embryonic stem cells, these data may indicate that the expression of these factors enables the tumours to have higher degree of stemness tumour cells, which in turn results in poorer clinical outcome for patients with esophageal squamous cell carcinomas.	19414369
Down Syndrome	Stem Cell Exhaustion	A systems biology approach to Down syndrome: identification of Notch/Wnt dysregulation in a model of stem cells aging.	19419698
Kidney Diseases, Nephrotic Syndrome	Stem Cell Exhaustion	To our knowledge, this patient is the youngest case with nephrotic syndrome due to membranous nephropathy after hematopoietic stem cell transplantation.	19424655
nervous system disorder	Stem Cell Exhaustion	Here, we report that neural stem/progenitor cells can also be cultured from rapid autopsy samples of SVZ from elderly human subjects, including patients with age-related neurologic disorders.	19425077
Osteosarcoma	Stem Cell Exhaustion	Increased number of mesenchymal stem cell-like cells in peripheral blood of patients with bone sarcomas.	19427966
Primary central nervous system lymphoma	Stem Cell Exhaustion	A successful treatment of relapsed primary CNS lymphoma patient with intraventricular rituximab followed by high-dose chemotherapy with autologous stem cell rescue.	19430564
Primary central nervous system lymphoma, Neurotoxicity Syndromes	Stem Cell Exhaustion	We describe a 46-year-old relapsed PCNSL patient who was successfully treated with intraventricular applications of rituximab to minimize neurotoxicity, 2 cycles of salvage chemotherapy with etoposide, ifosfamide, and cytarabine (VIA) regimen and high-dose chemotherapy with autologous stem cell rescue.	19430564
Neurotoxicity Syndromes	Stem Cell Exhaustion	Partial remission was detected after intraventricular rituximab therapy and the patient has been in complete remission without evidence of neurotoxicity for 28 months after high-dose chemotherapy with autologous stem cell rescue.	19430564
Myasthenia Gravis	Stem Cell Exhaustion	To describe a patient with intractable myasthenia gravis (MG) who was treated with a matched sibling peripheral blood stem cell transplantation.	19433668
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Myocardial homing and coronary endothelial function after autologous blood CD34+ progenitor cells intracoronary injection in the chronic phase of myocardial infarction.	19433985
Heart failure	Stem Cell Exhaustion	Transcoronary transplantation of progenitor cells has been proposed as a novel therapy for ischemic heart failure.	19433985
Coronary Arteriosclerosis	Stem Cell Exhaustion	Adiponectin levels are associated with the number and activity of circulating endothelial progenitor cells in patients with coronary artery disease.	19434763
Coronary Arteriosclerosis	Stem Cell Exhaustion	To study the relationship between plasma adiponectin concentration and the functional activities of circulating endothelial progenitor cells (EPCs) in patients with coronary artery disease (CAD).	19434763
Hollings Cancer Center, Carcinogenesis	Stem Cell Exhaustion	Our findings indicated that both viral hepatitis-associated ICC and HCC shared common disease process for carcinogenesis and, possibly, both arose from the hepatic progenitor cells.	19436294
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Further, treatment with TMPP significantly reduced the viability of AML specimens derived from AML patients, but only slightly reduced the viability of normal ALDH(hi) progenitor cells.	19436953
Infiltration	Stem Cell Exhaustion	Although renal infiltration generally shows a poor prognosis, long-term survival may be achieved with high dose chemotherapy and autologous peripheral blood stem cell transplantation.	19437146
Damage	Stem Cell Exhaustion	Early allogeneic hematopoietic stem cell transplantation (HSCT) should be considered before the manifestation of irreversible organ damage.	19437328
Specialty Type - cancer, Adenocarcinoma of large intestine	Stem Cell Exhaustion	Cancer stem cell markers CD133 and CD24 correlate with invasiveness and differentiation in colorectal adenocarcinoma.	19437567
Malignant tumor of colon, Specialty Type - cancer	Stem Cell Exhaustion	To verify that CD markers are available for detecting cancer stem cell populations and to evaluate their clinical significance in colon cancer.	19437567
Hodgkin Disease	Stem Cell Exhaustion	Outcomes for patients who fail high dose chemoradiotherapy and autologous stem cell rescue for relapsed and primary refractory Hodgkin lymphoma.	19438504
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	Most patients with Hodgkin lymphoma (HL) are cured with first and second-line treatment; however, the outcome is unknown for those who fail high dose chemoradiotherapy with autologous stem cell transplant (HDT-ASCT).	19438504
Acute lymphocytic leukemia	Stem Cell Exhaustion	Reduced-intensity conditioning allogeneic stem cell transplantation is a potential therapeutic approach for adults with high-risk acute lymphoblastic leukemia in remission: results of a prospective phase 2 study.	19440217
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	The aim of this prospective study was to investigate the feasibility of reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (SCT) in 37 adults with high-risk acute lymphoblastic leukemia (ALL) in first (n=30) or second (n=7) complete remission (CR).	19440217
Carcinosarcoma, Neoplasms	Stem Cell Exhaustion	Transdifferentiation, also seen in other tumors or carcinosarcomas, could be based on aberrant differentiation of a pluripotent stem cell.	19441090
Neutropenia, Hematologic Neoplasms, Pichia kudriavzevii	Stem Cell Exhaustion	Candida krusei candidemia was most commonly associated with prior use of antifungal agents (70.6%; P<.001), hematologic malignancy (52.9%; P<.001) or stem cell transplantation (17.7%; P<.001), neutropenia (45.1%; P<.001), and corticosteroid treatment (60.8%; P<.001).	19441981
Neoplasms	Stem Cell Exhaustion	A brief review of the clinical literature on collision tumor and tumor stem cells is presented.	19443356
Neoplasms, Colonic Neoplasms	Stem Cell Exhaustion	Collision tumors need to be distinguished from tumors originating from a progenitor cell with potential for multiphenotypic differentiation.	19443356
Hypophosphatasia	Stem Cell Exhaustion	New bone formation by allogeneic mesenchymal stem cell transplantation in a patient with perinatal hypophosphatasia.	19446101
Hypophosphatasia	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) can show osteogenic differentiation capability when implanted in vivo, as well as cultured in vitro; therefore we attempted to use allogeneic MSCs for an 8-month-old patient with hypophosphatasia.	19446101
Graft-vs-Host Disease	Stem Cell Exhaustion	Diffuse involvement of the gastrointestinal tract by graft versus host disease (GVHD) is a common complication of allogeneic hematopoietic stem cell transplant (HSCT).	19448368
Hematological Disease	Stem Cell Exhaustion	Sixty-eight patients with hematological diseases who underwent anticancer chemotherapy or stem cell transplantation were enrolled.	19449195
Metabolic Bone Disorder, diabetic	Stem Cell Exhaustion	In the pathophysiology of metabolic bone disease in diabetic patients, attention is currently being focused on the method in which the differentiation of mesenchymal stem cells in osteoblasts, or adipocytes is regulated.	19449752
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Cost utility of allogeneic stem cell transplantation with matched unrelated donor versus treatment with imatinib for adult patients with newly diagnosed chronic myeloid leukaemia.	19450068
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	To estimate, from the perspective of the German statutory health insurance, the cost utility of allogeneic stem cell transplantation with matched unrelated donor (MUD-SCT) in newly diagnosed, chronic-phase chronic myeloid leukaemia (CML) patients aged 40 years or younger, relative to the treatment with imatinib.	19450068
Specialty Type - cancer, Squamous cell carcinoma of the head and neck	Stem Cell Exhaustion	Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer.	19450560
Specialty Type - cancer	Stem Cell Exhaustion	Aldehyde dehydrogenase 1 (ALDH1) has been considered to be a marker for cancer stem cells.	19450560
Graft-vs-Host Disease, Stable chronic Graft vs Host Disease	Stem Cell Exhaustion	Chronic graft-versus-host-disease (cGVHD) is the major cause of late morbidity and mortality after allogeneic stem cell transplantation.	19450751
Communicable Diseases	Stem Cell Exhaustion	Cytomegalovirus (CMV) infection is 1 of the major causes of morbidity in patients undergoing allogeneic stem cell transplantation (allo-SCT).	19450752
Multiple Myeloma	Stem Cell Exhaustion	Age 40 years and under does not confer superior prognosis in patients with multiple myeloma undergoing upfront autologous stem cell transmplant.	19450753
Multiple Myeloma	Stem Cell Exhaustion	Impairment of filgrastim-induced stem cell mobilization after prior lenalidomide in patients with multiple myeloma.	19450756
Multiple Myeloma	Stem Cell Exhaustion	In 26 (9%) of 302 myeloma patients, stem cell mobilization failed.	19450756
Failure, Multiple Myeloma	Stem Cell Exhaustion	In patients with multiple myeloma, prior lenalidomide therapy is associated with failure of stem cell mobilization with filgrastim.	19450756
Graft-vs-Host Disease	Stem Cell Exhaustion	Early (day -7) versus conventional (day -1) inception of cyclosporine-A for graft-versus-host disease prophylaxis after unrelated donor hematopoietic stem cell transplantation in children.	19450759
Graft-vs-Host Disease, Hematologic Neoplasms	Stem Cell Exhaustion	We carried out a randomized, multicenter study comparing the inception of cyclosporine- A (CsA) on day -7 to conventional CsA (on day -1) to evaluate the influence of this modification on graft-versus-host disease (GVHD), treatment-related mortality (TRM), relapse rate (RR), and event-free survival (EFS) in children with hematologic malignancies given unrelated donor (UD) hematopoietic stem cell transplantation (HSCT).	19450759
Acute leukemia	Stem Cell Exhaustion	To investigate the efficacy and tolerability of well-fitting masks in high-risk patients, we conducted a prospective, randomised, multicentre study comparing standard hospital hygiene procedures with or without wearing masks in adults undergoing chemotherapy for acute leukaemia or allogeneic haematopoietic stem-cell transplantation (aHSCT).	19451183
Infection	Stem Cell Exhaustion	In this study we examined the effectiveness of chlorhexidine-silver sulfadiazine impregnated CVCs to prevent catheter-related infections in patients receiving high-dose chemotherapy followed by peripheral stem cell transplantation.	19453696
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Higher infused CD34+ hematopoietic stem cell dose correlates with earlier lymphocyte recovery and better clinical outcome after autologous stem cell transplantation in non-Hodgkin's lymphoma.	19453991
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Lymphocyte recovery after autologous stem cell transplantation (ASCT) has been shown to be associated with positive clinical outcome in non-Hodgkin's lymphoma (NHL).	19453991
Hepatobiliary Disorder, Amyloidosis	Stem Cell Exhaustion	Hepatic response after high-dose melphalan and stem cell transplantation in patients with AL amyloidosis associated liver disease.	19454500
Amyloidosis	Stem Cell Exhaustion	High-dose melphalan chemotherapy and autologous peripheral blood stem cell transplantation has been shown to result in durable hematologic response and prolonged overall survival in systemic AL amyloidosis.	19454500
Liver diseases	Stem Cell Exhaustion	In conclusion, hepatic disease improves in almost 2/3 patients treated with high-dose intravenous melphalan and autologous stem cell transplantation who have a complete or partial hematologic response to treatment.	19454500
Liver Cirrhosis	Stem Cell Exhaustion	Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: a phase I-II clinical trial.	19455046
Specialty Type - cancer	Stem Cell Exhaustion	When the migration rate is small, a single cancer stem cell can only generate a small, self-limited clone because of the finite life span of progeny and spatial constraints.	19455139
Neoplasms	Stem Cell Exhaustion	Tumours are heterogeneous populations composed of different cells types: stem cells with the capacity for self-renewal and more differentiated cells lacking such ability.	19455139
Up	Stem Cell Exhaustion	Although recent studies have shown that new neurons can be generated from progenitor cells in the neocortices of healthy adults, the neurogenic potential of the stem/progenitor cells of AD patients is not known.	19458225
Up	Stem Cell Exhaustion	To answer this question, we compared the properties of glial progenitor cells (GPCs) from the cortices of healthy control (HC) and AD subjects.	19458225
Up, Impaired	Stem Cell Exhaustion	These results suggest that Abeta-induced interruption of beta-catenin signaling may contribute to the impairment of neurogenesis in AD progenitor cells.	19458225
Disorder of the optic nerve	Stem Cell Exhaustion	A case of autoimmune-related retinopathy and optic neuropathy syndrome treated by autologous nonmyeloablative hematopoietic stem cell transplantation.	19458576
Abnormal vision	Stem Cell Exhaustion	A 47-year-old woman with progressive visual and hearing loss attributed to ARRON syndrome that was resistant to conventional therapies underwent autologous hematopoietic stem cell transplantation (HSCT).	19458576
Hypertension, CTCAE	Stem Cell Exhaustion	Hypertension induced by erythropoietin has a correlation with truncated erythropoietin receptor mRNA in endothelial progenitor cells of hemodialysis patients.	19458615
Hypertension, CTCAE	Stem Cell Exhaustion	To investigate the mechanism of EPO-induced hypertension, we examined circulating endothelial progenitor cells (EPCs) taken from 56 hemodialysis (HD) patients.	19458615
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Peripheral blood stem cell mobilisation by granulocyte-colony stimulating factor in patients with acute and old myocardial infarction for intracoronary cell infusion.	19460773
Coronary Arteriosclerosis	Stem Cell Exhaustion	Peripheral blood stem cells (PBSC) are one of the most promising stem cell sources for treatment of ischaemic heart disease.	19460773
Specialty Type - cancer, Benign prostatic hypertrophy	Stem Cell Exhaustion	Prostate stem cell antigen mRNA expression in preoperatively negative biopsy specimens predicts subsequent cancer after transurethral resection of the prostate for benign prostatic hyperplasia.	19462463
Prostate carcinoma, Benign prostatic hypertrophy	Stem Cell Exhaustion	Recent data showed that prostate stem cell antigen (PSCA) mRNA expression in transurethral resection of the prostate (TURP)-resected tissues predicted the subsequent prostate cancer after TURP in benign prostatic hyperplasia (BPH) patients with both PSA < 4.0 ng/ml and normal DRE findings.	19462463
GDC AJCC Clinical Stage Terminology, Acute Coronary Syndrome	Stem Cell Exhaustion	To compare the anti-inflammatory and endothelial progenitor cell mobilizing effects of ramipril and telmisartan in patients presenting with acute coronary syndrome (ACS), 42 patients with ACS were randomized after successful percutaneous coronary intervention to ramipril 5 mg/day (22 patients) or telmisartan 80 mg/day (20 patients).	19463506
Acute Coronary Syndrome	Stem Cell Exhaustion	Comparison of the effects of ramipril versus telmisartan on high-sensitivity C-reactive protein and endothelial progenitor cells after acute coronary syndrome.	19463506
Specialty Type - cancer, Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	Emerging evidence suggests that specific sub-populations of cancer cells with stem cell characteristics within the bulk of tumours are implicated in the pathogenesis of heterogeneous malignant tumours.	19464919
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	The cells that drive tumour growth have been denoted cancer-initiating cells or cancer stem cells (hereafter CSCs).	19464919
Cardiac complication, Hemopoietic stem cell transplant	Stem Cell Exhaustion	Cardiac complications in patients undergoing a reduced-intensity conditioning hematopoietic stem cell transplantation.	19465940
Deficiency	Stem Cell Exhaustion	On the other hand, it is not possible to avoid the limbic deficiency in these cases, which in the future will need limbal stem cell transplantation or other surgeries for correction of the ocular surface.	19466332
PAFAH1B1 wt Allele, Dysplasia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is a hematopoietic stem cell disorder characterized by ineffective hematopoiesis and dysplasia in one or more blood cell lines.	19469654
Failure, Colitis, Eczema, CTCAE	Stem Cell Exhaustion	An 8-months-old male infant with a mutation in the polyadenylation site of FOXP3 gene, absence of FOXP3 protein expression and clinical manifestations of IPEX syndrome, including eczema, colitis, failure to thrive, TPN requirement, and elevated serum IgE, underwent matched unrelated hematopoietic stem cell transplant.	19471859
Graft-vs-Host Disease	Stem Cell Exhaustion	Chronic graft versus host disease (GVHD) is a common late complication of hematopoietic stem cell transplantation.	19472035
Depressive disorder	Stem Cell Exhaustion	The purpose of this study of 23 adult haematopoietic stem cell transplantation (HSCT) recipients is to compare the presence of post-transplantation depression disorders by gender and to compare the outcomes among those with and without depressive disorders using a health psychology focus.	19473223
Anemia, Sickle Cell, Cardiac Arrest	Stem Cell Exhaustion	We show that lentiviral delivery of human gamma-globin gene under beta-globin regulatory control elements in hematopoietic stem cells (HSCs) results in sufficient postnatal fetal hemoglobin (HbF) expression to correct sickle cell anemia (SCA) in the Berkeley "humanized" sickle mouse.	19474450
Hodgkin Disease, Acute lymphocytic leukemia	Stem Cell Exhaustion	Epstein-Barr virus associated post-transplant Hodgkin lymphoma in an adult patient after cord blood stem cell transplantation for acute lymphoblastic leukemia.	19474517
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Post-transplant lymphoproliferative disorder (PTLD) is one of the most important complications of solid organ transplantation or hematopoietic stem cell transplantation.	19474517
Hodgkin Disease, Post-transplant lymphoproliferative disorder, LIPC gene	Stem Cell Exhaustion	Although post-transplant Hodgkin lymphoma (HL) is included in PTLD, there have been no studies in the literature on adult cases of post-transplant HL after cord blood stem cell transplantation (CBSCT).	19474517
Corneal Neovascularization, Limbal stem cell deficiency	Stem Cell Exhaustion	ProKera was most commonly used in patients with corneal neovascularization with or without limbal stem-cell deficiency (10 eyes).	19474753
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Continuous infusion idarubicin and intravenous busulphan as conditioning regimen to autologous stem cell transplantation for patients with acute myeloid leukaemia.	19475701
Toxic effect, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The current study aimed to evaluate the efficacy and toxicity of a combination of intravenous (iv) busulfan (Bu) and continuous infusion Idarubicin (IDA) as a conditioning regimen to autologous haematopoietic stem cell transplantation (ASCT) in patients with acute myeloid leukaemia (AML).	19475701
Specialty Type - cancer	Stem Cell Exhaustion	As one of the pluripotent factors involved in making induced pluripotent stem cells (iPS), lin-28 is considered a potential therapeutic target for cancer treatment.	19477633
Coronary Arteriosclerosis	Stem Cell Exhaustion	Genetic engineering with endothelial nitric oxide synthase improves functional properties of endothelial progenitor cells from patients with coronary artery disease: an in vitro study.	19479297
Impaired, Coronary Arteriosclerosis	Stem Cell Exhaustion	Recent studies have reported a marked impairment in the number and functions of endothelial progenitor cells (EPCs) in patients with coronary artery disease (CAD).	19479297
Stem Cell Factor	Stem Cell Exhaustion	SCF (stem cell factor) is a pleiotropic cytokine exerting its role at different stages of bone marrow development and affecting eosinophil activation, mast cells and basophil chemotaxis and survival.	19480722
Fibroid Tumor	Stem Cell Exhaustion	This is likely to represent rhabdomyosarcomatous differentiation in a leiomyomatous neoplasm or alternatively bidirectional differentiation from an uncommitted mesenchymal stem cell.	19483631
Lymphoma, Non-Hodgkin, Multiple Myeloma	Stem Cell Exhaustion	Safety and preliminary efficacy of plerixafor (Mozobil) in combination with chemotherapy and G-CSF: an open-label, multicenter, exploratory trial in patients with multiple myeloma and non-Hodgkin's lymphoma undergoing stem cell mobilization.	19483760
Hematopoietic Stem Cell Mobilization	Stem Cell Exhaustion	Further studies are warranted to evaluate the effect of plerixafor in combination with chemomobilization on stem cell mobilization and collection on the first and subsequent days of apheresis, and its impact on resource utilization.	19483760
Ocular surface disease, Corneal Perforation, Limbal stem cell deficiency, Communicable Diseases	Stem Cell Exhaustion	When corneal perforation develops in patients with severe ocular surface disease and limbal stem cell deficiency following childhood trachoma infection, penetrating keratoplasty is doomed to fail.	19485287
Epilepsy	Stem Cell Exhaustion	In contrast, the oligodendrocyte progenitor cell markers Olig2 and the surface antigen NG2 were expressed by the vast majority of cycling cells scattered throughout the cortex and white matter of both control and epileptic patients.	19486010
Multiple Myeloma	Stem Cell Exhaustion	Thirty-two patients with multiple myeloma who achieved only partial remission after allogeneic stem cell transplantation were treated with DLI.	19487069
Multiple Myeloma	Stem Cell Exhaustion	Retrospective comparison of bortezomib-containing regimens with vincristine-doxorubicin-dexamethasone (VAD) as induction treatment prior to autologous stem cell transplantation for multiple myeloma.	19487425
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Patients with multiple myeloma (MM) achieving high-quality responses, defined as a complete response (CR) and a very good partial response (VGPR) after transplant, benefit from high-dose therapy followed by autologous stem cell transplantation (ASCT).	19487425
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	The cancer stem cell (CSC) hypothesis suggests that CSCs are chemoresistant and enriched in recurrent tumors.	19488831
Graft-vs-Host Disease	Stem Cell Exhaustion	Imbalance of effector and regulatory CD4 T cells is associated with graft-versus-host disease after hematopoietic stem cell transplantation using a reduced intensity conditioning regimen and alemtuzumab.	19491336
Graft-vs-Host Disease	Stem Cell Exhaustion	A better understanding of the type of immune response causing graft-versus-host disease in defined clinical hematopoietic stem cell transplant settings is required to inform development of methods for monitoring patients and providing them tailored care.	19491336
Secondary Neoplasm	Stem Cell Exhaustion	Recent studies have showed that the bone marrow-derived endothelial progenitor cells play critical roles in metastasis and that ID1 is required in metastasis as regulator of angiogenesis.	19491902
Coronary Arteriosclerosis, Vascular System Injuries	Stem Cell Exhaustion	Levels of circulating endothelial progenitor cells (EPCs) and CXCR4-positive cells are decreased in patients with coronary artery disease (CAD); however, their ability to change in response to acute vascular injury remains to be elucidated.	19492159
Vascular System Injuries, Deficit	Stem Cell Exhaustion	Baseline levels of progenitor cells are differentially increased depending upon the severity of vascular injury incurred, regardless of a significant deficit in baseline levels in CAD patients.	19492159
Hematological Disease	Stem Cell Exhaustion	In Taiwan, haematopoietic stem cell transplantation (HSCT) has been used to treat patients with haematological diseases since 1983.	19494390
Hematologic Neoplasms	Stem Cell Exhaustion	Unrelated donor haematopoietic stem cell transplantation for adult patients with haematological malignancies.	19494392
Allogeneic Hematopoietic Stem Cell Transplantation, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	A 58-year-old man with myelodysplastic syndrome received allogeneic hematopoietic stem cell transplantation from an unrelated donor after being conditioned with fludarabine, melphalan, and total body irradiation.	19497045
Post-transplant lymphoproliferative disorder, Lymphoproliferative Disorders	Stem Cell Exhaustion	Epstein-Barr virus (EBV)-associated post-transplantation lymphoproliferative disease (PTLD) is a serious complication after allogeneic stem cell transplantation (SCT).	19497070
Malassezia	Stem Cell Exhaustion	Malassezia: is it a pulmonary pathogen in the stem cell transplant population?	19497074
Opportunistic fungal infection, Immunocompromised Host, Neutropenia, Infection caused by Malassezia	Stem Cell Exhaustion	Unlike many other common opportunistic fungal infections in immunocompromised hosts, neutropenia and the use of broad-spectrum antibiotics do not appear to be significant risk factors for Malassezia infections in the stem cell transplant (SCT) population.	19497074
Amyloidosis	Stem Cell Exhaustion	Successful treatment of primary AL amyloidosis by VAD therapy, high-dose melphalan, and autologous peripheral stem cell transplantation.	19499180
Proteinuria, Amyloidosis	Stem Cell Exhaustion	We report a 58-year-old Japanese man with primary systemic AL amyloidosis who achieved disappearance of proteinuria including Bence-Jones protein (lambda-type) after two courses of VAD therapy (vincristine, doxorubicin, and dexamethasone) and subsequent high-dose melphalan, followed by autologous peripheral blood stem cell transplantation.	19499180
Adult Glioblastoma	Stem Cell Exhaustion	Suppressing glioblastoma stem cell function by aldehyde dehydrogenase inhibition with chloramphenicol or disulfiram as a new treatment adjunct: an hypothesis.	19500061
Adult Glioblastoma, Specialty Type - cancer	Stem Cell Exhaustion	Strong expression of aldehyde dehydrogenase is a prominent feature of both normal and cancer stem cells, including the stem cell sub-population of glioblastoma.	19500061
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Cancer stem cells tend to be chemotherapy compared to the non-stem cell majority cell population in several common human cancers.	19500061
Adult Glioblastoma	Stem Cell Exhaustion	If a parallel situation obtains in glioblastoma stem cells, the migrating, far flung paucicellular extensions will be stem cell rich and use aldehyde dehydrogenase to generate the characteristic multiple metastases made up of mostly non-stem cells.	19500061
Neoplasms	Stem Cell Exhaustion	If GBM stem cell function can be thwarted by potent aldehyde dehydrogenase inhibition, they will be less able to regenerate a stem cell derived tumor mass after primary resection or chemotherapy.	19500061
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Aldehyde dehydrogenase function is used by cancer stem cells to repopulate a tumor mass after chemotherapy cytoreduction.	19500061
Degenerative polyarthritis	Stem Cell Exhaustion	The aim of this study was to examine the distribution of stem cell markers (Notch-1, Stro-1 and VCAM-1) and of molecules that modulate progenitor differentiation (Notch-1 and Sox9) in normal adult human articular cartilage and in osteoarthritis (OA) cartilage.	19500336
Degenerative polyarthritis	Stem Cell Exhaustion	Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis.	19500336
Up, Dementia	Stem Cell Exhaustion	Given that G-CSF is already utilized clinically to safely stimulate hematopoietic stem cell production, these basic research findings will be readily translated into clinical trials to reverse or forestall the progression of dementia in AD.	19500657
Liver carcinoma, Cirrhotic	Stem Cell Exhaustion	Differential role of circulating endothelial progenitor cells in cirrhotic patients with or without hepatocellular carcinoma.	19501032
Liver carcinoma, Hypertension, CTCAE	Stem Cell Exhaustion	Circulating endothelial progenitor cells have a negative prognostic impact in patients with hepatocellular carcinoma, but may play a different role in portal hypertension according to preclinical data.	19501032
Cirrhotic	Stem Cell Exhaustion	Endothelial progenitor cells levels in peripheral blood were elevated in cirrhotic (n=23) (mean: 0.12+/-0.06% S.D.)	19501032
Liver carcinoma	Stem Cell Exhaustion	Notably, hepatic venous pressure gradient was positively correlated with vascular endothelial growth factor (r=0.5, P=0.046) but negatively with endothelial progenitor cells levels (r=-0.51, P=0.02) in cirrhotics, but not hepatocellular carcinoma patients.	19501032
Liver Cirrhosis	Stem Cell Exhaustion	The negative correlation of endothelial progenitor cells with hepatic venous pressure gradient suggests a protective role of endothelial progenitor cells in liver cirrhosis whilst vascular endothelial growth factor is associated with high hepatic venous pressure gradient.	19501032
Liver carcinoma, Neoplasms	Stem Cell Exhaustion	In contrast, increased endothelial progenitor cells in hepatocellular carcinoma rather reflect tumour specific endothelial progenitor cells mobilisation.	19501032
Hepatitis B, Hepatitis B Antibodies	Stem Cell Exhaustion	We investigated the serological changes in hepatitis B virus (HBV)-related markers in 55 and 26 hepatitis B surface antigen (HBsAg)-negative patients undergoing allogeneic and autologous stem cell transplantation, respectively, over the past 4 yr. Five of the 17 allogeneic and one of the five autologous patients with pretransplant anti-hepatitis B core antigen antibodies (anti-HBc) were HBsAg-positive after transplantation, whereas none of the patients negative for anti-HBc were HBsAg-positive in both groups.	19508685
Neoplasms	Stem Cell Exhaustion	Primary tumor samples exhibited a variable degree of immunoreactivity for CD133/1, ranging from 1.3% to 62.6%, but stained negatively for other endothelial and stem cell-associated markers.	19509143
Endometrial Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	CD133 is expressed by human endometrial cancers and might represent a valuable tool to identify cells with cancer stem cell characteristics.	19509143
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells represent an attractive therapeutic target for tumor eradication.	19509143
Endometrial Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Cells with characteristics of cancer stem/progenitor cells express the CD133 antigen in human endometrial tumors.	19509143
Endometrial Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	The present study aimed to determine whether CD133 expression may identify cells with characteristics of cancer stem/progenitor cells in human endometrial tumors.	19509143
Malignant neoplasm of breast, Childhood Breast Carcinoma	Stem Cell Exhaustion	Association of breast cancer stem cells identified by aldehyde dehydrogenase 1 expression with resistance to sequential Paclitaxel and epirubicin-based chemotherapy for breast cancers.	19509181
Childhood Breast Carcinoma	Stem Cell Exhaustion	Breast cancer stem cells have been shown to be associated with resistance to chemotherapy in vitro, but their clinical significance remains to be clarified.	19509181
Malignant neoplasm of breast, Specialty Type - cancer	Stem Cell Exhaustion	The aim of this study was to investigate whether cancer stem cells were clinically significant for resistance to chemotherapy in human breast cancers.	19509181
Childhood Breast Carcinoma, Neoplasms	Stem Cell Exhaustion	Breast cancer stem cells were identified by immunohistochemical staining of CD44/CD24 and aldehyde dehydrogenase 1 (ALDH1) in tumor tissues obtained before and after neoadjuvant chemotherapy.	19509181
Neoplasms	Stem Cell Exhaustion	CD44(+)/CD24(-) tumor cells or ALDH1-positive tumor cells were considered stem cells.	19509181
Childhood Breast Carcinoma	Stem Cell Exhaustion	Our findings suggest that breast cancer stem cells identified as ALDH1-positive, but not CD44(+)/CD24(-), play a significant role in resistance to chemotherapy.	19509181
Childhood Breast Carcinoma	Stem Cell Exhaustion	ALDH1-positive thus seems to be a more significantly predictive marker than CD44(+)/CD24(-) for the identification of breast cancer stem cells in terms of resistance to chemotherapy.	19509181
Vasculitis, CTCAE	Stem Cell Exhaustion	Reduced number of endothelial progenitor cells is predictive of early relapse in anti-neutrophil cytoplasmic antibody-associated vasculitis.	19509188
Corneal Endothelial Cell Loss	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPCs) may provide an endogenous repair mechanism to counteract ongoing endothelial damage.	19509188
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	High-dose therapy (HDT) followed by autologous stem cell transplantation (ASCT) is the most common treatment for patients under 65 years of age with multiple myeloma (MM).	19513515
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	With chemotherapy and progenitor stem cell transplantation, about 60% of patients with DLBCL are long-term survivors.	19517471
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	DNA copy number changes identified by array comparative genomic hybridization (array-CGH) were studied in 40 patients who had DLBCL with a poor prognosis and who were treated uniformly with dose-escalated cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) and intensification before high-dose chemotherapy with autologous stem cell transplantation.	19517471
Multiple Myeloma	Stem Cell Exhaustion	Serum free light chain ratio, total kappa/lambda ratio, and immunofixation results are not prognostic factors after stem cell transplantation for newly diagnosed multiple myeloma.	19520760
Multiple Myeloma	Stem Cell Exhaustion	We evaluated disease response using serum immunofixation (s-IFIX), total kappa and lambda ratio (KLR), and free light chain (FLC) ratio in myeloma patients who underwent autologous or autologous plus allogeneic stem cell transplantation.	19520760
Acute myocardial infarction	Stem Cell Exhaustion	Intracoronary administration of stem cells in patients with acute myocardial infarction - angiographic follow-up.	19521932
Mucoepidermoid Carcinoma	Stem Cell Exhaustion	A link between the expression of the stem cell marker HMGA2, grading, and the fusion CRTC1-MAML2 in mucoepidermoid carcinoma.	19521953
Specialty Type - cancer	Stem Cell Exhaustion	Recently, the concept of cancer stem cells and their expression of embryonic stem cell markers has gained considerable experimental support.	19521953
Multiple Myeloma	Stem Cell Exhaustion	Thrombopoietic cytokine and P-selectin levels in patients with multiple myeloma undergoing autologous stem cell transplantation: decrease in posttransplantation P-selectin levels might predict the degree of maximum response.	19525192
Megakaryocytopoiesis, Multiple Myeloma	Stem Cell Exhaustion	This study was designed to determine the pretransplantation levels of thrombopoietic cytokines, which have a fundamental role in both megakaryopoiesis and myeloma pathogenesis and P-selectin in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation (AHSCT) and to correlate the cytokine levels with time to platelet recovery.	19525192
Chronic heart failure, Coronary heart disease	Stem Cell Exhaustion	[Influence of shenfu injection on heart function and bone marrow stem cell mobilization in patients with chronic heart failure of coronary heart disease].	19526754
Chronic heart failure	Stem Cell Exhaustion	To explore the influence of Shenfu Injection (SFI) on heart function and bone marrow stem cell mobilization in patients with chronic heart failure.	19526754
Cerebrovascular accident	Stem Cell Exhaustion	After one week of treatment, the cardiac function indexes, including left ventricular ejection fraction (LVEF), stroke volume (SV) and cardiac output (CO), as well as the number of CD34+ stem cells in the peripheral blood were detected and compared.	19526754
Myeloid to Erythroid Ratio Measurement	Stem Cell Exhaustion	Investigation of novel genes dysregulated in response to malarial pigment (hemozoin [PfHz]) revealed that stem cell growth factor (SCGF; also called C-type lectin domain family member 11A [CLEC11A]), a hematopoietic growth factor important for development of erythroid and myeloid progenitors, was one of the most differentially expressed genes.	19528216
Coronary Arteriosclerosis, Ventricular Dysfunction, Left	Stem Cell Exhaustion	Endothelial progenitor cells in patients with coronary artery disease and left ventricular dysfunction.	19528795
Lung Injury, Communicable Diseases	Stem Cell Exhaustion	As lung transplantation is associated with lung injury, which is severe early on and exacerbated during episodes of infection and rejection, we hypothesized that circulating epithelial progenitor cell levels could predict clinical outcome following lung transplantation.	19529775
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	"Cancer stem cells" (CSC) have been identified as a minority of cancer cells responsible for tumor initiation, maintenance and spreading.	19530513
JAK2 NP_004963.1:p.V617F, Lymphoid neoplasm	Stem Cell Exhaustion	The JAK2V617F mutation was found in lymphoid tumor cells in two of three cases evaluated, indicating that, in some patients, LPN originated in a JAK2V617F mutated common lymphoid-myeloid hematopoietic progenitor cell.	19531676
Lymphoproliferative Disorders	Stem Cell Exhaustion	[Lymphoproliferative disorder as a complication after haematopoietic stem cell transplantation].	19531835
RAPH1 gene, Lymphoproliferative Disorders	Stem Cell Exhaustion	Lymphoproliferative disorders (LPD) occur often in EBV-infected patients, especially in solid-organ and haematopoietic stem cell transplant recipients.	19531835
Cerebrovascular accident	Stem Cell Exhaustion	Autologous bone marrow stem cell neurotransplantation in stroke patients.	19531871
Cerebrovascular accident	Stem Cell Exhaustion	Bone marrow stem cells (BMSC) were transplanted into the perilesional area in five patients bearing sequels of stroke, to evaluate the safety of the procedure and tolerance to the transplanted cells.	19531871
leukemia	Stem Cell Exhaustion	[Demographic characteristics of patients with leukemia waiting for stem cell transplantation in Chinese Marrow Donor Program during 2000 to 2006].	19534874
leukemia	Stem Cell Exhaustion	The majority of leukemia patients for waiting stem cell transplantation were registered among children and the adolescents groups, males were suffered more than the females.	19534874
leukemia	Stem Cell Exhaustion	The distributive of patients with leukemia for waiting stem cell transplantation was different in 30 areas, and the peak region of leukemia should be in Jiangsu, Guangdong, Shangdong, and Zhejiang provinces.	19534874
Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Phase II study of bryostatin 1 and vincristine for aggressive non-Hodgkin lymphoma relapsing after an autologous stem cell transplant.	19536846
Lymphoma, Non-Hodgkin, Familial, Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	We tested the efficacy and safety of bryostatin 1 50 microg/m(2) given over 24 hr and vincristine 1.4 mg/m(2) on days 1 and 15 every 28 days in aggressive B-cell non-Hodgkin lymphoma (NHL) relapsing after autologous stem cell transplantation.	19536846
Childhood Ependymoma, Specialty Type - cancer, Epilepsies, Partial	Stem Cell Exhaustion	Taken together, the tumor localization-related gene sets mainly implicated in stem cell maintenance, renewal, and differentiation suggest the dysregulation of localized cancer stem cells during ependymoma development.	19536879
Brain Diseases, Metabolic, Multiple Myeloma	Stem Cell Exhaustion	Hypercytokinemia-induced metabolic encephalopathy in a multiple myeloma patient on hemodialysis undergoing autologous stem cell transplantation: clinical response after plasma exchange.	19539028
Kidney Failure, Chronic	Stem Cell Exhaustion	We report here a 50-years old female with multiple myeloma-associated chronic renal failure who underwent high-dose chemotherapy supported by autologous hematopoietic stem cell transplantation.	19539028
Mycoses	Stem Cell Exhaustion	Cost-effectiveness analysis of micafungin versus fluconazole for prophylaxis of invasive fungal infections in patients undergoing hematopoietic stem cell transplantation in Korea.	19539111
Mycoses	Stem Cell Exhaustion	Invasive fungal infections are often fatal complications in patients undergoing hematopoietic stem cell transplantation (HSCT), and prophylactic antifungal treatment has been recommended.	19539111
Acute GVH disease	Stem Cell Exhaustion	Adult human mesenchymal stem cells added to corticosteroid therapy for the treatment of acute graft-versus-host disease.	19539211
Graft-vs-Host Disease	Stem Cell Exhaustion	The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them a rationale agent to investigate for graft-versus-host disease (GVHD).	19539211
Kidney Failure, Multiple Myeloma	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation may reverse renal failure in patients with multiple myeloma.	19539212
Toxic effect	Stem Cell Exhaustion	Many of these patients are considered ineligible for autologous hematopoietic stem cell transplantation (auto-HSCT) because of a high risk of treatment-related toxicity.	19539212
Splenic Rupture	Stem Cell Exhaustion	Rare reports of splenic rupture have been associated with filgrastim treatment during peripheral blood progenitor cell (PBPC) mobilization in allogeneic donors.	19539214
Endothelial dysfunction, Peripheral Arterial Diseases	Stem Cell Exhaustion	We hypothesized that granulocyte macrophage colony-stimulating factor (GM-CSF) administration will be safe and will improve endothelial dysfunction and exercise capacity by mobilizing progenitor cells in patients with peripheral arterial disease (PAD).	19540392
Endothelial dysfunction	Stem Cell Exhaustion	Granulocyte macrophage colony-stimulating factor therapy in patients with PAD was associated with mobilization of progenitor cells, improvement of endothelial dysfunction, and exercise capacity.	19540392
Hematopoietic and Lymphoid Cell	Stem Cell Exhaustion	Multivariate analysis showed that serum beta2-microglobulin (P = .003) together with the presence of mast/stem cell growth factor receptor gene (KIT) mutation in mast cells plus myeloid and lymphoid hematopoietic lineages (P = .02) was the best combination of independent parameters for predicting disease progression (cumulative probability of disease progression of 1.7% +/- 1.2% at 5-10 years and of 8.4% +/- 5.0% at 20-25 years).	19541349
Neoplasms	Stem Cell Exhaustion	The aim was to assess the safety and efficacy of plerixafor for stem cell mobilization and tumor cell contamination.	19543330
Pneumonia	Stem Cell Exhaustion	Acute fibrinous and organizing pneumonia following hematopoietic stem cell transplantation.	19543497
Kidney Failure, Chronic, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	He had a history of acute myeloid leukemia and hematopoietic stem cell transplantation with chronic renal failure.	19543497
Depression, CTCAE, Anxiety Disorders	Stem Cell Exhaustion	Do coping and social support predict depression and anxiety in patients undergoing hematopoietic stem cell transplantation?	19544178
Depression, CTCAE, Anxiety Disorders	Stem Cell Exhaustion	This study examined whether different types of coping and social support predict anxiety and depression in 212 hematopoietic stem cell transplant (HSCT) recipients.	19544178
Diabetes	Stem Cell Exhaustion	Various attempts have been made to develop stem cell-based therapy to alleviate type I diabetes using animal models.	19544420
Diabetes	Stem Cell Exhaustion	Insulin-secreting cells from human eyelid-derived stem cells alleviate type I diabetes in immunocompetent mice.	19544420
Diabetes	Stem Cell Exhaustion	In this study, we isolated neural crest-like stem cells from the human eyelid fat and examined their therapeutic potentials for diabetes.	19544420
Diabetes	Stem Cell Exhaustion	In conclusion, human insulin alone produced from eyelid-derived stem cells following differentiation into insulin-secreting cells and transplantation could normalize type I diabetes in mice.	19544420
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Highly tumorigenic cancer cell (HTC) populations have been identified for a variety of solid tumors and assigned stem cell properties.	19544456
CEACAM6 wt Allele	Stem Cell Exhaustion	We identified a highly tumorigenic UC cell compartment that resembles benign urothelial stem cells (basal cells), co-expresses the 67-kDa laminin receptor and the basal cell-specific cytokeratin CK17, and lacks the carcinoembryonic antigen family member CEACAM6 (CD66c).	19544456
Multiple Myeloma	Stem Cell Exhaustion	A 59-year-old man with multiple myeloma underwent autologous hematopoetic stem cell transplantation (AHSCT).	19548772
Glaucoma, Primary Open Angle, Ocular Hypertension, Endothelial dysfunction	Stem Cell Exhaustion	Reduced endothelial progenitor cells and brachial artery flow-mediated dilation as evidence of endothelial dysfunction in ocular hypertension and primary open-angle glaucoma.	19549102
Glaucoma, Primary Open Angle, Glaucoma, CTCAE, Ocular Hypertension	Stem Cell Exhaustion	This study aimed to assess vascular endothelial function in patients with ocular hypertension (OHT) or primary open-angle glaucoma (POAG) by measuring: (a) endothelium-dependent flow-mediated vasodilation (FMD) of the brachial artery, and (b) circulating endothelial progenitor cells, which are believed to support the integrity of the vascular endothelium.	19549102
Barrett Esophagus	Stem Cell Exhaustion	Lgr5, an intestinal stem cell marker, is abnormally expressed in Barrett's esophagus and esophageal adenocarcinoma.	19549212
Malignant Neoplasms, Barrett Esophagus, Malignant tumor of colon, Liver carcinoma, Malignant neoplasm of ovary	Stem Cell Exhaustion	Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5), a recently discovered intestinal stem cell marker, is expressed in premalignant lesions including Barrett's esophagus (BE) and cancers including colon cancer, ovarian cancer, and hepatocellular carcinoma.	19549212
Neoplasms, Malignant tumor of colon, Specialty Type - cancer	Stem Cell Exhaustion	It was also recently found to be expressed in tumor spheres prepared from colon cancer, suggesting that it will likely serve as a cancer stem cell marker.	19549212
Infection	Stem Cell Exhaustion	The epidemiology of invasive Streptococcus pneumoniae infections in onco-haematology and haematopoietic stem cell transplant patients in France.	19549222
Multiple Myeloma, Amyloidosis	Stem Cell Exhaustion	[Auto-hematopoietic stem cell transplantation for multiple myeloma accompanied with amyloidosis in four limbs].	19549405
Specialty Type - cancer, Primary malignant neoplasm	Stem Cell Exhaustion	To elucidate whether MT1 might play a role in cancer cells positive for the stem cell marker nestin, we assessed paired carcinomatous (Ca) and adjacent noncancerous (NCa) samples from 42 patients with primary breast cancer for MT1 and nestin by double immunofluorescence staining and quantitative image analysis with Tissue-Quest software.	19552766
Mucopolysaccharidosis II, Cord blood stem cell	Stem Cell Exhaustion	Localized donor cells in brain of a Hunter disease patient after cord blood stem cell transplantation.	19556155
Mucopolysaccharidosis II	Stem Cell Exhaustion	The efficacy of hematopoietic stem cell transplantation (HSCT) for Hunter disease (deficiency of iduronate-2-sulfatase, IDS) remains unclear.	19556155
Mucopolysaccharidosis II, Cord Blood Stem Cell Transplantation, Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	We treated a 6-year-old male suffering from a severe type of Hunter disease with cord blood stem cell transplantation (CBSCT); however, he died at 10 months post-therapy due to a laryngeal post-transplantation lymphoproliferative disorder.	19556155
Aniridia	Stem Cell Exhaustion	Three different stages of epithelial characteristics were found in congenital aniridia and pemphigoid: (i) CK19-negative and inhomogenous CK12-positive cases indicating epithelium mainly from (partly) CK12-deficient limbal stem cells; (ii) CK19- and/or goblet cell-positive and CK12-positive cases with their epithelia originating from CK12-deficient limbal stem cells and from incursing conjunctival cells; and (iii) CK19-positive and CK12-negative cases consisting of conjunctival cells alone.	19558573
Myocardial Ischemia	Stem Cell Exhaustion	The stem cell therapy for treating ischemic diseases is promising; however, the limited availability and compromised quality of progenitor cells in aged and diseased patients limit its therapeutic use.	19558779
Myocardial Ischemia	Stem Cell Exhaustion	Additionally, proangiogenic growth factors overexpression in progenitor cells can potentially improve autologous or allogeneic stem cell therapy for ischemic diseases.	19558779
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic stem cell transplantation (SCT) is the most efficient antileukaemic treatment for patients with AML, but eligibility for the treatment was confined for a long time to younger patients.	19561407
Acute leukemia	Stem Cell Exhaustion	Reduced-toxicity conditioning therapy with allogeneic stem cell transplantation for acute leukemia.	19561406
Hematologic Neoplasms	Stem Cell Exhaustion	Reduced-intensity conditioning (RIC) has allowed the use of allogeneic stem cell transplantation (alloSCT) for haematological malignancies in elderly patients.	19561408
Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation, Infection, Malignant Neoplasms, Mycoses	Stem Cell Exhaustion	Infections in non-myeloablative hematopoietic stem cell transplantation patients with lymphoid malignancies: spectrum of infections, predictors of outcome and proposed guidelines for fungal infection prevention.	19561648
Infection	Stem Cell Exhaustion	The overall risk of infections is lower in patients undergoing non-myeloablative allogeneic stem cell transplantation (NST) than in conventional stem cell transplant recipients.	19561648
Aggressive behavior, Specialty Type - cancer	Stem Cell Exhaustion	Variability of tumor aggressiveness as a micro-evolutionary process of cancer stem cells with predetermined prognosis].	19562240
Specialty Type - cancer	Stem Cell Exhaustion	Formation of cancer stem cells which are both rare and variably therapy-resistant marks the beginning of a new disease without precursors.	19562240
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	The primary tumor acts as the supplier of cancer stem cells for metastases which appear in different organs.	19562240
Specialty Type - cancer	Stem Cell Exhaustion	When chemotherapy is administered the distribution of metastases in different organs appears dependent of the response or non-response of cancer stem cells to this therapy.	19562240
Acute GVH disease, Tumor necrosis	Stem Cell Exhaustion	Tumor necrosis factor-alpha is a key inflammatory cytokine involved in acute GVHD physiopathology, and infliximab has shown encouraging results for the treatment of acute GVHD following hematopoietic stem cell transplantation.	19562700
Childhood Breast Carcinoma, MYELODYSPLASTIC SYNDROME, Acute leukemia	Stem Cell Exhaustion	Acute leukemia and myelodysplasia after adjuvant chemotherapy for breast cancer: durable remissions after hematopoietic stem cell transplantation.	19564171
Neoplasms, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	A putative tumor suppressor gene, TET2, was recently implicated in MPN and myelodysplastic syndromes through the identification of acquired mutations affecting hematopoietic stem cells.	19564637
Blistering eruption, Watery, Cholestasis, Graft-vs-Host Disease, Leukemia, Myelocytic, Acute, Hemorrhagic diarrhea	Stem Cell Exhaustion	A 42 year-old woman develops steroid refractory graft-versus-host disease (GVHD) after second allogeneic stem cell transplantation for acute myelogenous leukemia with severe GVHD of her skin with blisters, severe GVHD of her gut with watery and bloody diarrhea and GVHD of her liver with cholestasis.	19565209
Diastolic dysfunction, Weight Gain, Atrial Fibrillation by ECG Finding	Stem Cell Exhaustion	Acute weight gain and diastolic dysfunction as a potent risk complex for post stem cell transplant atrial fibrillation.	19565646
Bone Marrow Suppression, Atrial Fibrillation by ECG Finding	Stem Cell Exhaustion	The management of atrial fibrillation (AF) following stem cell transplant (SCTX) is often challenging because of the universal presence of profound bone marrow suppression.	19565646
B-Cell Lymphomas	Stem Cell Exhaustion	Rituximab versus observation after high-dose consolidative first-line chemotherapy with autologous stem-cell transplantation in patients with poor-risk diffuse large B-cell lymphoma.	19567453
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	This study compared the induction regimens doxorubicin, cyclophosphamide and etoposide (ACE) with doxorubicin, cyclophosphamide, vincristine, bleomycin and prednisone (ACVBP) before high-dose therapy (HDT) followed by autologous stem-cell transplantation (ASCT) for patients with poor-risk diffuse large B-cell lymphoma (DLBCL).	19567453
RUNX1 protein, human	Stem Cell Exhaustion	Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells.	19570512
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Leukemia stem cells (LSCs) initiate and sustain the acute myeloid leukemia (AML) clonal hierarchy and possess biological properties rendering them resistant to conventional chemotherapy.	19570512
Hematologic Neoplasms	Stem Cell Exhaustion	We studied the appearance of free, non-transferrin-bound iron (NTBI) at baseline and during the 20-d period after the onset of cytotoxic chemotherapy in patients with haematological malignancy undergoing intensive chemotherapy or conditioning for autologous stem cell transplantation (aSCT).	19572995
Graft-vs-Host Disease, Intra-alveolar hemorrhage, Leucocytic infiltrate	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HSCT) recipients, all of whom had graft-versus-host disease, had more inflammatory cell infiltration but less intra-alveolar hemorrhage than non-HSCT patients (67% versus 14%, P=0.04; 50% versus 100%, P=0.02, respectively).	19576639
Unspecified visual loss	Stem Cell Exhaustion	Interview: stemming vision loss with stem cells: seeing is believing.	19580400
Up, Stem Cell Factor	Stem Cell Exhaustion	In the present study we investigated the impact of a 15-month treatment with the AChE inhibitor donepezil on blood levels of the HGFs stem cell factor (SCF), stromal cell-derived factor 1 (SDF-1), granulocyte colony- stimulating factor (G-CSF) and vascular endothelial growth factor (VEGF) in 19 patients with AD and 45 age-matched healthy controls.	19580698
Hepatitis B	Stem Cell Exhaustion	[Change in the serologic markers of hepatitis B after allogenic hematopoietic stem-cell transplantation].	19581765
Hepatitis B, Communicable Diseases	Stem Cell Exhaustion	This study examined the effects of hepatitis B virus (HBV) infection state and immunologic capability in both the recipients and donors of allogenic hematopoietic stem-cell transplantation (allo-HSCT) on changes in HBV serologic markers in recipients.	19581765
Communicable Diseases	Stem Cell Exhaustion	However, a reactivation of HBV can occur following hematopoietic stem-cell transplantation in the cases of recipients or donors with a history of HBV, infection by an accompanying immune suppression.	19581765
Malignant neoplasm of stomach	Stem Cell Exhaustion	Association of prostate stem cell antigen gene polymorphisms with the risk of stomach cancer in Japanese.	19582881
Malignant neoplasm of stomach	Stem Cell Exhaustion	A recent whole-genome association study identified a strong association between polymorphisms in the prostate stem cell antigen (PSCA) gene and stomach cancer risk.	19582881
Vascular lesions, Chronic Kidney Diseases	Stem Cell Exhaustion	This suggests that vascular lesions could stimulate progenitor cell mobilization, even in a context of reduced EPC induced by CKD.	19583820
Chronic Kidney Diseases, Vascular System Injuries	Stem Cell Exhaustion	In conclusion, uremic toxins and vascular injury appear to affect endothelial progenitor cell biology in CKD.	19583820
Vascular System Injuries	Stem Cell Exhaustion	Levels of circulating endothelial progenitor cells are related to uremic toxins and vascular injury in hemodialysis patients.	19583820
Chronic Kidney Diseases	Stem Cell Exhaustion	CKD patients have reduced numbers of endothelial progenitor cells, but little is known about the factors influencing these numbers.	19583820
Vascular System Injuries	Stem Cell Exhaustion	Among these factors, we hypothesized that uremic toxins and vascular injury affect endothelial progenitor cells.	19583820
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Much attention has been recently focused on the role of cancer stem cells (CSCs) in the initiation and progression of solid malignancies.	19583859
Venoocclusive disease	Stem Cell Exhaustion	Prior treatment with gemtuzumab ozogamicin and the risk of veno-occlusive disease after allogeneic haematopoietic stem cell transplantation.	19584826
Coronary Arteriosclerosis	Stem Cell Exhaustion	Habitual physical activity is associated with endothelial function and endothelial progenitor cells in patients with stable coronary artery disease.	19587603
Coronary Arteriosclerosis	Stem Cell Exhaustion	Exercise training reduces mortality in patients with coronary artery disease (CAD); however, the impact of habitual physical activity level (PAL) on vascular endothelial function and circulating endothelial progenitor cells (EPCs) remain unknown.	19587603
Neoplasms	Stem Cell Exhaustion	Four courses of BEP therapy [cisplatin (CDDP), bleomycin (BLM), etoposide (VP-16)] and a high dose chemotherapy followed by a peripheral blood stem cell transplantation made the tumor become smaller and effected its down-staging.	19588824
Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients.	19589136
Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	The persistence of circulating tumor cells (CTC) in breast cancer patients might be associated with stem cell like tumor cells which have been suggested to be the active source of metastatic spread in primary tumors.	19589136
Childhood Breast Carcinoma	Stem Cell Exhaustion	Here we evaluated 226 blood samples of 39 metastatic breast cancer patients during a follow-up of palliative chemo-, antibody - or hormonal therapy for the expression of the stem cell marker ALDH1 and markers for EMT and correlated these findings with the presence of CTC and response to therapy.	19589136
Neoplasms	Stem Cell Exhaustion	The recovered c-DNA was additionally multiplex tested for three EMT markers [Twist1, Akt2, PI3Kalpha] and separately for the tumor stem-cell markers ALDH1.	19589136
Childhood Breast Carcinoma, Neoplasms	Stem Cell Exhaustion	Our data indicate that a major proportion of CTC of metastatic breast cancer patients shows EMT and tumor stem cell characteristics.	19589136
Graft-vs-Host Disease	Stem Cell Exhaustion	Severe graft-versus-host disease (GVHD) and graft rejection still remain major complications of haploidentical nonmyeloablative (NMA) stem cell transplantation.	19589482
Graft-vs-Host Disease	Stem Cell Exhaustion	The purpose of this study was to observe if the new strategy, which included a haploidentical peripheral blood stem cell transplantation (PBSCT) combined with MSCs, modified NMA conditioning, and GVHD prophylaxis would improve donor engraftment and prevent severe GVHD.	19589482
Adverse reaction to drug	Stem Cell Exhaustion	We have analyzed by immunohistochemistry the number of CD3+ T lymphocytes and FOXP3+ Tregs in skin biopsies from (1) recipients of allogeneic hematopoietic stem cell transplantation (HSCT, n = 26), (2) nontransplanted patients diagnosed with cutaneous drug reaction (n = 12), and (3) healthy donors (n = 10).	19589483
Childhood Breast Carcinoma	Stem Cell Exhaustion	Although multiple randomized trials of high-dose chemotherapy and autologous progenitor cell transplantation (ASCT) for the treatment of breast cancer have yielded disappointing results, these data are not necessarily relevant to IBC, a distinct clinical and pathologic entity.	19589486
Acute GVH disease	Stem Cell Exhaustion	Low serum levels of total rabbit-IgG is associated with acute graft-versus-host disease after unrelated donor hematopoietic stem cell transplantation: results from a prospective study.	19589490
Uremia, Ischemia	Stem Cell Exhaustion	Perioperative iloprost and endothelial progenitor cells in uremic patients with severe limb ischemia undergoing peripheral revascularization.	19589539
Limb structure	Stem Cell Exhaustion	New vessel growth develops not exclusively by proliferation of endothelial cells in vascular extremities but also by cells mobilized from the bone marrow (HSC), transformed into endothelial progenitor cells (EPC) contributing to both re-endothelialization and neovascularization.	19589539
Uremia, Ischemia	Stem Cell Exhaustion	The aim of this study was to evaluate the effects of perioperative treatment with iloprost in uremic patients with acute ischemia of lower limbs, undergoing surgical revascularization, on endothelial progenitor cells, hypothesizing a possible biological mechanism induced by the prostanoids.	19589539
Multiple Myeloma	Stem Cell Exhaustion	Peripheral blood stem cell collection in multiple myeloma: a retrospective analysis of 6 years leukapheresis activity in 109 patients treated at the Istituto Nazionale dei Tumori of Milan.	19591198
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Double autologous stem cell transplantation is the standard treatment in newly diagnosed multiple myeloma (MM) patients younger than 65 years; therefore, optimization of leukapheresis is crucial.	19591198
Vasculitis, CTCAE, Toxic effect, Sepsis-associated lung injury, Decreased platelet count	Stem Cell Exhaustion	Vasculitis was causative in 19%, drug toxicity in 11%, thrombocytopenia in 27%, stem-cell transplantation in 5%, sepsis-associated lung injury in 22%, and unknown mechanisms in 16%.	19592204
Hematologic Neoplasms	Stem Cell Exhaustion	Sixty-four (58%) patients had hematologic malignancies; 27 patients had undergone hematopoietic stem cell transplantation.	19593226
Infection, Specialty Type - cancer	Stem Cell Exhaustion	The combination of tigecycline and an antipseudomonal drug may be appropriate for treating refractory infections and multidrug-resistant organisms in cancer patients, including hematopoietic stem cell transplant recipients.	19593226
Fetal Measurements Domain	Stem Cell Exhaustion	As a reduced-intensity stem-cell transplantation (RIST) regimen, the combination of fludarabine and melphalan (FM) with an appropriate immunosuppressant reduces nonrelapse mortality (NRM).	19593609
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Higher incidence of relapse with peripheral blood rather than marrow as a source of stem cells in adults with acute myelocytic leukemia autografted during the first remission.	19597030
Lymphoma, Non-Hodgkin, Neoplasms, Multiple Myeloma	Stem Cell Exhaustion	Mobilization of peripheral blood stem cells for autologous transplant in non-Hodgkin's lymphoma and multiple myeloma patients by plerixafor and G-CSF and detection of tumor cell mobilization by PCR in multiple myeloma patients.	19597422
Myeloid Leukemia	Stem Cell Exhaustion	Functional unresponsiveness and replicative senescence of myeloid leukemia antigen-specific CD8+ T cells after allogeneic stem cell transplantation.	19602548
Myeloid neoplasm	Stem Cell Exhaustion	The therapeutic effect of allogeneic hematopoietic stem cell transplantation (HSCT) for patients with myeloid malignancies has been attributed in part to a graft-versus-leukemia effect that is dependent on donor T lymphocytes.	19602548
Anemia	Stem Cell Exhaustion	Allogeneic stem cell transplantation for patients with refractory anaemia with matched related and unrelated donors: delay of the transplant is associated with inferior survival.	19604243
Anemia	Stem Cell Exhaustion	Allogeneic stem cell transplantation (alloSCT) for patients with refractory anaemia may result in a 50% event-free survival, but the high non-relapse mortality (NRM) precludes a general application of this therapeutic modality.	19604243
EYA1 wt Allele, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Consistently, BOR and PSI enhanced IM-induced inhibition of long-term clonogenic activity and short-term cell growth of CML stem/progenitor cells, and potentiated IM-caused inhibition of proliferation and induction of apoptosis of BCR-ABL+ cells.	19606213
Polypoidal choroidal vasculopathy	Stem Cell Exhaustion	[Circulating bone marrow-derived stem cells in patients with polypoidal choroidal vasculopathy].	19606806
Polypoidal choroidal vasculopathy, methyldopa	Stem Cell Exhaustion	The current study was designed to investigate the role of circulating bone marrow (BM)-derived stem cells in the pathogenesis of polypoidal choroidal vasculopathy (PCV), a distinct type of neovascular age-related macular degeneration (AMD).	19606806
methyldopa	Stem Cell Exhaustion	Similar to CNV associated with AMD, impaired functional activity of circulating BM-derived stem cells was observed in PCV patients with bilateral or larger lesions.	19606806
Acute lymphocytic leukemia, Myeloid Leukemia, Chronic, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We report outcomes of 932 recipients of unrelated donor peripheral blood stem cell hematopoietic cell transplantation (URD-PBSC HCT) for acute myeloid leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia, and myelodysplastic syndrome enrolled on a prospective National Marrow Donor Program trial from 1999 through 2003.	19608747
Stem Cell Factor	Stem Cell Exhaustion	Before and immediately after the coronary intervention, blood granulocyte-colony-stimulating factor (G-CSF), stem-cell factor (SCF), vascular endothelial growth factor (VEGF), and stroma-derived factor-1 (SDF-1alpha) were measured.	19609048
Coronary Arteriosclerosis	Stem Cell Exhaustion	In conclusion, our data suggest that the benefits of late reperfusion of a totally occluded IRA in patients with ongoing myocardial ischemia may involve mechanisms associated with stem cell-mobilizing and plaque-stabilizing cytokines.	19609048
Cytomegalovirus Infections	Stem Cell Exhaustion	Adoptive transfer of donor-derived cytomegalovirus (CMV)-specific T cells may provide long-lived protection from CMV disease after allogeneic stem cell transplantation.	19609244
Hematologic Neoplasms, Opportunistic Infections, Mycoses	Stem Cell Exhaustion	Intensive treatment of hematological malignancies with hematopoietic stem cell transplantation (HSCT) is accompanied by a high incidence of opportunistic invasive fungal infection, but individual risk varies significantly.	19614557
Gastrointestinal Stromal Tumors, Promotional Kit, Stem Cell Factor	Stem Cell Exhaustion	In the remaining 26 wild-type GISTs, KIT, stem cell factor (SCF), phospho-KIT and phospho-ERK expression was evaluated by immunohistochemistry.	19614767
Aspergillus, Zygomycosis, Fusarium, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We describe a case of fatal disseminated Scopulariopsis infection in a 56-year-old neutropenic male with chronic myelogenous leukemia status post peripheral blood stem cell transplant that was clinically and histologically indistinguishable from disseminated Aspergillus, Fusarium or zygomycosis infection.	19615008
JAK2 NP_004963.1:p.V617F	Stem Cell Exhaustion	(Chromosomally abnormal progenitor cells are closely associated with JAK2V617F homozygosity; p=0.0001.).	19615425
JAK2 NP_004963.1:p.V617F, Chromosome Aberrations	Stem Cell Exhaustion	These findings support the existence of earlier genetic events that precede JAK2V617F or cytogenetic abnormalities in MPN hematopoietic progenitor cells.	19615425
Infection of bloodstream	Stem Cell Exhaustion	A fall in bloodstream infections followed a change to 2% chlorhexidine in 70% isopropanol for catheter connection antisepsis: a pediatric single center before/after study on a hemopoietic stem cell transplant ward.	19616869
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We describe a rare ophthalmologic manifestation of CNS relapse in a 25-year-old patient with AML who had undergone allogeneic stem cell transplant, and demonstrate the value of MRI in the early diagnosis.	19618016
Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	Circulating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancer.	19619935
Childhood Breast Carcinoma	Stem Cell Exhaustion	In conclusion, we report the existence of a subpopulation of CTCs with putative stem cell progenitor phenotypes in patients with metastatic breast cancer.	19619935
Angioimmunoblastic Lymphadenopathy	Stem Cell Exhaustion	Allogeneic stem cell transplantation is able to induce long-term remissions in angioimmunoblastic T-cell lymphoma: a retrospective study from the lymphoma working party of the European group for blood and marrow transplantation.	19620487
Angioimmunoblastic Lymphadenopathy	Stem Cell Exhaustion	To analyze the long-term outcome in terms of nonrelapse mortality (NRM), relapse rate (RR), progression-free survival (PFS), and overall survival (OS) in patients with angioimmunoblastic T-cell lymphoma (AITL) treated with allogeneic stem-cell transplantation (alloSCT).	19620487
Failure	Stem Cell Exhaustion	Median age was 48 years (range, 23 to 68 years), 34 patients had received > or = two lines of chemotherapy before alloSCT, and 11 patients had experienced treatment failure with a prior autologous stem-cell transplantation.	19620487
Myeloproliferative disease	Stem Cell Exhaustion	Mutant hematopoietic stem cells yield a myeloproliferative-like disorder in xenotransplantation and syngenic mouse bone marrow engraftment assays.	19620628
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	The occurrence of autoantibodies has been reported in allogeneic stem-cell recipients, but the association of this occurrence with chronic graft-versus-host disease (cGVHD) or survival remains uncertain.	19623021
Stable chronic Graft vs Host Disease	Stem Cell Exhaustion	The occurrence of autoantibodies after allogeneic stem-cell transplantation was found to be related to cGVHD, and patients expressing autoantibodies had a better survival.	19623021
Leukemia, Myelocytic, Acute, Immunocompromised Host	Stem Cell Exhaustion	Xenotransplantation of human acute myeloid leukemia (AML) in immunocompromised animals has been critical for defining leukemic stem cells.	19626050
Colorectal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Prognostic significance of the cancer stem cell markers CD133, CD44, and CD166 in colorectal cancer.	19626493
Colorectal Carcinoma	Stem Cell Exhaustion	CD133, CD44, and CD166 are cell surface markers that have recently been associated with colorectal cancer stem cells.	19626493
Chronic myeloproliferative disorder, Childhood B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1	Stem Cell Exhaustion	We have used the ECFC and CFU-EC assays to readdress the issue of the clonal relation between endothelial progenitor cells and hematopoietic stem cells in patients with Philadelphia-positive and Philadelphia-negative chronic myeloproliferative disorders.	19628707
Congenital Heart Defects	Stem Cell Exhaustion	This study was designed to find the effects of age on circulating endothelial progenitor cells (EPCs) and their mobilization in infants and young children following surgical correction of congenital heart defects.	19632131
Multiple Myeloma	Stem Cell Exhaustion	Retrospective evaluation of response and survival among 758 consecutive patients with multiple myeloma treated at a single center, of whom 395 patients received intensive therapy supported by autologous stem cells within the first year.	19633690
Candida (fungus), Hematologic Neoplasms, Candidemia	Stem Cell Exhaustion	The incidence, epidemiology, Candida species distribution, resistance patterns, and outcome of candidemia in high-risk hematologic malignancy and/or stem cell transplantation patients have not been extensively described since the introduction of new antifungal agents.	19634156
Chronic Lymphoproliferative Disorder of NK-Cells	Stem Cell Exhaustion	Rituximab based therapy followed by autologous stem cell transplantation leads to superior outcome and high rates of PCR negativity in patients with indolent B-cell lymphoproliferative disorders.	19635181
Lymphoproliferative Disorders	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) and rituximab based therapy represent effective treatments of indolent B-cell lymphoproliferative disorders (B-LPDs) that often induce molecular remission (MR).	19635181
Toxic effect, Multiple Myeloma	Stem Cell Exhaustion	Toxicity of a second autologous peripheral blood stem cell transplant in patients with relapsed or recurrent multiple myeloma.	19637091
Toxic effect, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Toxicity associated with a second autologous peripheral blood stem cell transplant (APBSCT) in patients who relapse following initial APBSCT for multiple myeloma (MM) has not been well described.	19637091
Hypertrophy	Stem Cell Exhaustion	Subcellular localization of IRS-1 in IGF-I-mediated chondrogenic proliferation, differentiation and hypertrophy of bone marrow mesenchymal stem cells.	19639489
Hematological Disease, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	It was investigated whether the European Group for Blood and Marrow Transplantation risk score, previously established for chronic myeloid leukemia, could be used to predict outcome after allogeneic hematopoietic stem cell transplantation (HSCT) for hematological disease in general.	19642176
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	In patients with myelodysplasia, a general defect in the multipotent stem-cell compartment results in disturbed proliferation and differentiation of the erythroid, megakaryocytic and myeloid lineages.	19644139
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Although a number of genetic defects in myelodysplastic progenitor cells have been described, the intracellular signaling pathways underlying aberrant regulation of myelopoiesis remain relatively undefined.	19644139
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Here, an ex vivo differentiation system was used to selectively screen for molecules improving defective hematopoiesis in myelodysplastic CD34(+) progenitor cells.	19644139
Respiratory Tract Infections	Stem Cell Exhaustion	Timing and severity of community acquired respiratory virus infections after myeloablative versus non-myeloablative hematopoietic stem cell transplantation.	19644142
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	For patients with recurrent or refractory large B-cell non-Hodgkin's lymphoma, high-dose chemotherapy and autologous stem cell transplant (ASCT) is the treatment of choice.	19647953
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	The results of stem cell therapy after myocardial infarction (MI) have been conflicting.	19649993
Blood Vessel	Stem Cell Exhaustion	Also, more insight is needed whether CECs as detected by this assay predominantly measures CECs or also endothelial progenitor cells (EPCs), which originate from the bone marrow and reflect angiogenesis rather than vascular damage.	19652886
Failure	Stem Cell Exhaustion	These findings suggest that the PNH-type cells in patients with BM failure are derived from single PIGA mutant haematopoietic stem cells even when their percentages are <1% and their fate depends on the proliferation and self-maintenance properties of the individual PIGA mutants.	19656154
Graft-vs-Host Disease	Stem Cell Exhaustion	A 56-year-old man was diagnosed with Mycobacterium genavense duodenitis 21 months after an allogeneic peripheral stem cell transplant complicated by graft-versus-host disease requiring intense immunosuppression.	19656345
Specialty Type - cancer	Stem Cell Exhaustion	We investigated the role of three stem cell markers (CD133, OCT4, and SOX2) in rectal cancer and evaluated the association between these gene levels and clinical outcome in rectal cancer patients with preoperative CRT.	19657699
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells are associated with metastatic potential, treatment resistance, and poor patient prognosis.	19657699
Specialty Type - cancer, Glioblastoma	Stem Cell Exhaustion	These data suggest that STAT3 regulates the growth and self-renewal of GBM-SCs and is thus a potential target for cancer stem cell-directed therapy of glioblastoma multiforme.	19658181
Adult Glioblastoma	Stem Cell Exhaustion	STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells.	19658181
Adult Glioblastoma	Stem Cell Exhaustion	Recently, putative glioblastoma stem cells (GBM-SCs) were isolated and characterized.	19658181
Retinal Pigments	Stem Cell Exhaustion	Derivation of functional retinal pigmented epithelium from induced pluripotent stem cells.	19658190
Amyotrophic Lateral Sclerosis, Familial	Stem Cell Exhaustion	Transient recovery in a rat model of familial amyotrophic lateral sclerosis after transplantation of motor neurons derived from mouse embryonic stem cells.	19660174
Hematuria, CTCAE, Renal Insufficiency, Communicable Diseases	Stem Cell Exhaustion	BK virus infection is associated with hematuria and renal impairment in recipients of allogeneic hematopoetic stem cell transplants.	19660716
Kidney Diseases	Stem Cell Exhaustion	BK virus (BKV) is an important pathogen and cause of nephropathy in renal transplant recipients, but its significance following hematopoetic stem cell transplantation (HSCT) is less well described.	19660716
Renal Insufficiency	Stem Cell Exhaustion	Moderate renal function impairment does not affect outcomes of reduced-intensity conditioning with fludarabine and melphalan for allogeneic hematopoietic stem cell transplantation.	19660722
Immunocompromised Host	Stem Cell Exhaustion	The purpose of the study was to evaluate whether the knowledge of clinical data improves the diagnostic sensitivity of CXR in the particular setting of immunocompromised patients after hematopoietic stem cell transplantation (HSCT).	19662340
Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	Isolation of circulating epithelial and tumor progenitor cells with an invasive phenotype from breast cancer patients.	19662651
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	Of 15 patients with PNH, six underwent allogenic stem cell transplantation after diagnosis of BCS.	19664836
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	Stem cell transplantation appears to be a feasible treatment option for PNH in BCS patients.	19664836
Intravascular hemolysis, Venous Thrombosis, Paroxysmal nocturnal hemoglobinuria, Hematological Disease	Stem Cell Exhaustion	PNH is an acquired disorder of hematopoietic stem cells, characterized by intravascular hemolysis and venous thrombosis.	19664836
Cytomegalovirus Infections	Stem Cell Exhaustion	Cytomegalovirus infection and disease after reduced intensity conditioning allogeneic stem cell transplantation: single-centre experience.	19668235
Cytomegalovirus Infections	Stem Cell Exhaustion	The aim of this study was to analyse the incidence and risk factors for cytomegalovirus infection (CMV-I) and disease (CMV-D) after a reduced intensity conditioning allogeneic hematopoietic stem cell transplantation (alloHSCT-RIC).	19668235
Pregnancy Complications, Infectious	Stem Cell Exhaustion	Comparison of infectious complications during induction/consolidation chemotherapy versus allogeneic hematopoietic stem cell transplantation.	19668238
Hematologic Neoplasms, Infection	Stem Cell Exhaustion	Induction/consolidation chemotherapy and allogeneic hematopoietic stem cell transplantation (HSCT) for hematological malignancies are associated with treatment-related risks such as infections.	19668238
Metabolic Syndrome X	Stem Cell Exhaustion	The main goal of the Austrian Moderate Altitude Study (AMAS) was to investigate (a) the consequences of an active vacation at moderate altitude on the key parameters of the metabolic syndrome (AMAS I) and (b) the effects of a short active vacation on adult progenitor cells, bio-psychological parameters, and heart rate variability (HRV).	19669819
Bone lesion	Stem Cell Exhaustion	Autollogous stem-cell transplantation is also recommended in literature for patients with generalized bone lesions or progressive and disease-resistant therapy.	19670534
B-Cell Lymphomas, Lymphoma	Stem Cell Exhaustion	High rate of survival in transformed lymphoma after autologous stem cell transplant: pathologic analysis and comparison with de novo diffuse large B-cell lymphoma.	19672775
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Recently, a cancer stem cell (CSC) hypothesis has emerged describing a small subset of tumor cells with stem cell properties.	19676044
Hematologic Neoplasms, Aspergillosis	Stem Cell Exhaustion	Predicting survival in adults with invasive aspergillosis during therapy for hematological malignancies or after hematopoietic stem cell transplantation: Single-center analysis and validation of the Seattle, French, and Strasbourg prognostic indexes.	19676118
Liver carcinoma, Malignant neoplasm of liver	Stem Cell Exhaustion	Here, we show that cadherin-17 (CDH17) adhesion molecule is up-regulated in human liver cancers and can transform premalignant liver progenitor cells to produce liver carcinomas in mice.	19676131
Pneumonia	Stem Cell Exhaustion	Legionella is a common cause of health-care--associated pneumonia, particularly in settings with hematopoietic stem-cell or solid-organ transplant recipients.	19680220
Specialty Type - cancer, Squamous cell carcinoma	Stem Cell Exhaustion	Recent molecular biological studies have identified podoplanin as a candidate cancer stem cell (CSC) marker in squamous cell carcinoma (SqCC).	19681903
Amyotrophic Lateral Sclerosis	Stem Cell Exhaustion	Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: A Phase I clinical trial.	19682989
Antilymphocyte Serum	Stem Cell Exhaustion	Stem-cell-based therapies represent a new possible strategy for ALS clinical research.	19682989
Toxic effect, Antilymphocyte Serum	Stem Cell Exhaustion	The objectives of this Phase 1 clinical study were to assess the feasibility and toxicity of mesenchymal stem cell transplantation and to test the impact of a cell therapy in ALS patients.	19682989
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Efficacy of autologous bone marrow-derived stem cell transplantation in patients with type 2 diabetes mellitus.	19686048
Beta-cell dysfunction, Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Progressive and inexorable beta-cell dysfunction is the hallmark of type 2 diabetes mellitus (T2DM) and beta-cell regeneration using stem cell therapy may prove to be an effective modality.	19686048
Hollings Cancer Center	Stem Cell Exhaustion	Many established biomarkers for hepatic progenitor cells were over-expressed in H-JNK1 HCC, including AFP, TACSTD1, KRT19, KRT7, THY1, and PROM1.	19686584
Hollings Cancer Center	Stem Cell Exhaustion	Accordingly, we believe that the H-JNK1 HCC may originate from hepatic progenitor cells and is associated with poorer prognosis.	19686584
Acute leukemia	Stem Cell Exhaustion	Biphenotypic acute leukemia (BAL) is a rare entity that comprises 0.5-3% of all acute leukemias and probably arises from multipotent progenitor cells.	19687594
Hypertension, CTCAE	Stem Cell Exhaustion	Effects of Xuezhikang and pravastatin on circulating endothelial progenitor cells in patients with essential hypertension.	19688314
Hypertensive (finding)	Stem Cell Exhaustion	To investigate the impacts of Xuezhikang (XZK) or pravastatin combined with antihypertensive drugs on circulating endothelial progenitor cells (CEPCs) in essential hypertensive (EH) patients.	19688314
Ischemia	Stem Cell Exhaustion	[Autologous bone-marrow stem-cell transplantation for induction of arteriogenesis for limb salvage in critical limb ischaemia].	19688676
Peripheral demyelinating neuropathy	Stem Cell Exhaustion	Autologous peripheral blood stem cell transplantation for chronic acquired demyelinating neuropathy.	19691534
Peripheral demyelinating neuropathy	Stem Cell Exhaustion	Six patients with chronic acquired demyelinating neuropathy (CADP) were treated with autologous peripheral blood stem cell transplantation (PBSCT).	19691534
Multiple Myeloma, Acute lymphocytic leukemia	Stem Cell Exhaustion	Donor cell-derived acute lymphocytic leukemia after allogeneic stem cell transplantation for multiple myeloma.	19693451
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Intensive treatments like autologous blood stem cell transplantations are standard consolidation treatments for lymphoma and myeloma in young people.	19693499
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Post-autologous stem cell transplantation administration of rituximab improves the outcome of patients with aggressive B cell non-Hodgkin's lymphoma.	19693502
Aggressive Non-Hodgkin Lymphoma, Failure, Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	The major cause of treatment failure following high-dose therapy with autologous stem cell transplantation (ASCT) for aggressive B cell non-Hodgkin's lymphoma (NHL) is persistent disease or recurrence.	19693502
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal diseases of pluripotent hematopoietic stem or progenitor cells.	19694218
Diabetes Mellitus	Stem Cell Exhaustion	Alleviation of exogenous insulin requirement in type 1 diabetes mellitus after immunoablation and transplantation of autologous hematopoietic stem cells.	19694226
Lymphoproliferative Disorders	Stem Cell Exhaustion	Epstein-Barr virus (EBV) is important in the development of post-transplant lymphoproliferative disease in allogeneic stem cell and solid organ transplant recipients.	19694766
Toxic effect	Stem Cell Exhaustion	The mobilization of CD34(+) hematopoietic stem cells did not increase after treatment (p = 0.58), and there was no relationship with toxicity.	19695439
Aggressive behavior, S100A4 protein, human, Carcinoma	Stem Cell Exhaustion	Polycomb-group proteins Bmi1 is regarded as a "stemness" gene involved in the maintenance of stem cells, malignant transformation, and biologic aggressiveness of several human carcinomas.	19695678
Graft-vs-Host Disease, Cholestasis	Stem Cell Exhaustion	The aim of the study was to assess variations in the diameter of the common bile duct in patients with gastrointestinal graft-versus-host disease (GVHD) undergoing abdominal CT after allogeneic hematopoietic stem cell transplantation and to correlate the findings with laboratory results on cholestasis.	19696256
Hematologic Neoplasms, Acute on chronic graft-versus-host disease, Infection	Stem Cell Exhaustion	Hematopoietic stem-cell transplantation is a well-established treatment in various hematologic malignancies, but the outcome depends on disease relapse, infections, and the development and severity of acute and chronic graft-versus-host disease.	19696636
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	Of about 20% of patients with relapsed/refractory Hodgkin lymphoma (HL), approximately half achieve long-term remissions after high-dose chemoradiotherapy and autologous stem cell transplantation (HDT/ASCT).	19701081
Hepatic Veno-Occlusive Disease, Venoocclusive disease	Stem Cell Exhaustion	Hepatic Sinusoidal Obstruction Syndrome (HSOS), the new name given to veno-occlusive disease (VOD) of the liver, is a well-known complication of high-dose chemotherapy employed with hematopoietic stem cell transplantation, but it has rarely been observed in children who receive conventional chemotherapy.	19701718
TCL4 gene, Injury of cornea, Eczema, CTCAE	Stem Cell Exhaustion	Successful treatment of young-onset adult T cell leukemia/lymphoma and preceding chronic refractory eczema and corneal injury by allogeneic hematopoietic stem cell transplantation.	19705056
Adult T-Cell Lymphoma/Leukemia	Stem Cell Exhaustion	A 25-year-old female developed ATLL and underwent allogeneic hematopoietic stem cell transplantation (HSCT) in non-remission.	19705056
Aplastic Anemia	Stem Cell Exhaustion	Aplastic anemia (AA) is most frequently due to autoimmune attack on its own stem cells.	19705116
Malignant neoplasm of ovary	Stem Cell Exhaustion	These antigens may prove to be markers of 'repopulating' cells with stem cell-like characteristics and could be critical targets for immunotherapy in epithelial ovarian cancer (EOC).	19705800
Pregnancy Complications, Infectious	Stem Cell Exhaustion	Infectious complications associated with alemtuzumab use for allogeneic hematopoietic stem cell transplantation: comparison with anti-thymocyte globulin.	19708893
Pregnancy Complications, Infectious	Stem Cell Exhaustion	To evaluate the incidence of infectious complications after receiving alemtuzumab as part of a conditioning regimen for allogeneic hematopoietic stem cell transplantation (HSCT) in Korean patients.	19708893
Cardiovascular Diseases	Stem Cell Exhaustion	This genomic region contains the gene encoding cyclin-dependent kinase 2A, a regulator of proliferation and differentiation of endothelial progenitor cell (EPC) which has been implicated in vascular repair and protection against cardiovascular disease.	19709660
Cartilage damage, Musculoskeletal	Stem Cell Exhaustion	Recently, this therapy has been used in the treatment of a number of musculoskeletal pathologies on the basis of the effects produced by the induction of angiogenesis, recruitment of progenitor cells and downregulation of cartilage damage.	19711161
Myocardial Ischemia	Stem Cell Exhaustion	A number of preclinical studies have indicated the therapeutic potential of endothelial progenitor cells for vascular regeneration in ischemic diseases.	19711453
Endometrial Carcinoma, Myoma	Stem Cell Exhaustion	[The plasma levels and diagnostic utility of stem cell factor in patients with endometrial cancer and myoma uteri].	19711726
Stem Cell Factor	Stem Cell Exhaustion	Stem cell factor (SCF) is a member of a group of cytokines called hematopoietic growth factors (HGFs).	19711726
Adenocarcinoma, Adenoma of large intestine	Stem Cell Exhaustion	Expression of putative stem cell genes Musashi-1 and beta1-integrin in human colorectal adenomas and adenocarcinomas.	19714342
Hematologic Neoplasms, Graft vs Leukemia Effect	Stem Cell Exhaustion	Through an immune-mediated graft-versus-leukemia effect, allogeneic hematopoietic stem cell transplantation (HSCT) affords durable clinical benefits for many patients with hematologic malignancies.	19717467
Thrombomodulin Alfa	Stem Cell Exhaustion	Here, we retrospectively compared the incidence of TMA in patients given allogeneic hematopoietic stem cells after either nonmyeloablative (n=176) or high-dose (n=111) conditioning.	19718063
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Phase III prospective randomized double-blind placebo-controlled trial of plerixafor plus granulocyte colony-stimulating factor compared with placebo plus granulocyte colony-stimulating factor for autologous stem-cell mobilization and transplantation for patients with non-Hodgkin's lymphoma.	19720922
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	This study evaluates the safety and efficacy of plerixafor (AMD3100), a CXCR4 antagonist, in mobilizing hematopoietic stem cells for autologous stem-cell transplantation in non-Hodgkin's lymphoma (NHL) patients.	19720922
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Patients with non-Hodgkin's lymphoma requiring an autologous hematopoietic stem-cell transplantation in first or second complete or partial remission were eligible.	19720922
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cell marker CD133+ tumour cells and clinical outcome in rectal cancer.	19723143
Colorectal Carcinoma	Stem Cell Exhaustion	The CD133 antigen has been identified as a putative stem cell marker in colorectal cancer tissues.	19723143
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	According to the cancer stem cell hypothesis, CD133+ cells determine long-term tumour growth and are therefore suspected of influencing clinical outcome.	19723143
Specialty Type - cancer	Stem Cell Exhaustion	The expression of the CD133 stem cell antigen in a series of 73 patients with rectal cancer of various ypTNM stages was analysed by immunohistochemistry on formalin-fixed paraffin-embedded sections.	19723143
Specialty Type - cancer	Stem Cell Exhaustion	CD133 stem cell antigen expression correlates with patient survival in rectal cancer, lending support to the current cancer stem cell hypothesis.	19723143
Glaucoma, CTCAE	Stem Cell Exhaustion	Preoperative comorbidities included glaucoma [27 patients (73%)] and limbal stem cell deficiency [13 patients (35%)].	19724214
Ischemic stroke, Cerebrovascular accident	Stem Cell Exhaustion	Bone marrow-derived progenitor cells in the early phase of ischemic stroke: relation with stroke severity and discharge outcome.	19724287
Ischemic stroke, Infarction	Stem Cell Exhaustion	A limited number of studies suggested that in ischemic stroke patients, the number of bone marrow circulating progenitor cells (CPCs), either endothelial progenitor cells (EPCs) or CPCs, was negatively correlated with the number of infarcts as well as with the outcome.	19724287
Malignant tumor of colon	Stem Cell Exhaustion	CD133 has been postulated to be a colon cancer stem cell (CSCs) marker.	19724847
Medial collateral ligament	Stem Cell Exhaustion	Seven patients with MCL stayed free from progression after high-dose therapy with autologous or allogeneic stem cell transplantation in two and five cases, respectively.	19727725
Complication Aspects	Stem Cell Exhaustion	To study the incidence, causes, and outcome of major ocular complications in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT).	19729097
Complication Aspects	Stem Cell Exhaustion	There was no correlation between the pattern of ocular complications and the transplanted stem cell source.	19729097
Deficiency of testosterone biosynthesis	Stem Cell Exhaustion	Synergistic effects of asymmetrical dimethyl-L-arginine accumulation and endothelial progenitor cell deficiency on renal function decline during a 2-year follow-up in stable angina.	19729464
Neoplasms, Esophageal Neoplasms	Stem Cell Exhaustion	This tumor 'embryonization' supports the idea that stem or progenitor cells are implicated in esophageal cancer emergence.	19732125
Multiple Myeloma	Stem Cell Exhaustion	The purpose of this study was to evaluate the efficacy and safety of short-course bortezomib, melphalan, prednisone (VMP) in previously untreated multiple myeloma as frontline therapy for transplant-ineligible patients and induction prior to autologous stem cell transplantation (ASCT).	19733251
Infantile neuronal ceroid lipofuscinosis	Stem Cell Exhaustion	Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis.	19733542
Multiple Myeloma	Stem Cell Exhaustion	A polymorphism in NFKB1 is associated with improved effect of interferon-{alpha} maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support.	19734419
Multiple Myeloma	Stem Cell Exhaustion	Maintenance therapy with interferon-alpha after high-dose treatment with stem cell support in multiple myeloma has been intensively debated.	19734419
Acquired aplastic anemia	Stem Cell Exhaustion	Improved outcome of patients older than 30 years receiving HLA-identical sibling hematopoietic stem cell transplantation for severe acquired aplastic anemia using fludarabine-based conditioning: a comparison with conventional conditioning regimen.	19734425
Aplastic anemia, idiopathic	Stem Cell Exhaustion	Older age is a limitation for HLA-identical sibling hematopoietic stem cell transplantation (HSCT) as first-line therapy for severe acquired idiopathic aplastic anemia (SAA).	19734425
Hemophilia A	Stem Cell Exhaustion	A 22-year-old male with severe haemophilia A and high responding factor VIII (FVIII) inhibitor underwent sibling haematopoietic stem cell transplantation in an attempt to eradicate the inhibitor.	19735311
Erythropoietic Protoporphyria	Stem Cell Exhaustion	Delayed immune recovery following sequential orthotopic liver transplantation and haploidentical stem cell transplantation in erythropoietic protoporphyria.	19735434
Peritoneal Gliomatosis, Teratoma	Stem Cell Exhaustion	The pathophysiology of gliomatosis peritonei was originally thought to be the direct extrusion or lymphatic spread of glial cells from the associated teratoma, although it has been postulated that the glial implants may instead be the result of pluripotent Mullerian stem cells that undergo metaplasia.	19735831
Specialty Type - cancer, Lung Neoplasms, Drug-induced	Stem Cell Exhaustion	Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: implications for drug resistance and in vitro drug screening models.	19738435
Specialty Type - cancer, Lung Neoplasms	Stem Cell Exhaustion	We show that this re-growth is associated with the presence of cancer stem cells (CSCs) in lung tumor cell population.	19738435
Cervix carcinoma	Stem Cell Exhaustion	Vascular endothethial growth factor (VEGF) and stem cell factor (c-KIT) signaling may play a role in the development and progression of cervical carcinoma.	19740535
B-Cell Lymphomas	Stem Cell Exhaustion	Low nonrelapse mortality and prolonged long-term survival after reduced-intensity allogeneic stem cell transplantation for relapsed or refractory diffuse large B cell lymphoma: report of the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire.	19744569
Graft-vs-Host Disease	Stem Cell Exhaustion	Although allogeneic hematopoietic progenitor cell transplant (HPCT) is curative therapy for many disorders, it is associated with significant morbidity and mortality, which can be related to graft-versus-host disease (GVHD) and the immunosuppressive measures required for its prevention and/or treatment.	19744572
Neoplasms	Stem Cell Exhaustion	OS1 cells, derived from a pre-chemotherapeutic tumor in the femur of a 6-year-old female, were examined for molecular markers characteristic for osteoblasts, stem cells, and cell cycle control by immunohistochemistry, reverse transcriptase-PCR, Western blotting and flow cytometry.	19746444
Left ventricular ejection fraction	Stem Cell Exhaustion	Outcome of allogeneic hematopoietic stem cell transplantation in patients with low left ventricular ejection fraction.	19747634
Allogeneic Hematopoietic Stem Cell Transplantation	Stem Cell Exhaustion	A high risk of regimen-related toxicity with allogeneic hematopoietic stem cell transplantation (allo-HSCT) limits this potentially curative treatment for patients with a left ventricular ejection fraction (LVEF) of > or =50%.	19747634
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation as an intensive consolidation therapy for adult patients in remission from acute myelogenous leukemia.	19747639
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Autologous peripheral blood stem/progenitor cell transplantation (APBSCT) has been investigated as a potential therapeutic option to improve outcome in patients with acute myelogenous leukemia (AML).	19747639
Avascular Necrosis, CTCAE	Stem Cell Exhaustion	Decreased in the number and function of circulation endothelial progenitor cells in patients with avascular necrosis of the femoral head.	19747991
Avascular Necrosis of Femur Head	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPCs) numbers and functions are reduced in ANFH patients, suggesting that risk factors of ANFH may alter EPCs biology in angiogenesis and vascular repair.	19747991
Lymphoma, Non-Hodgkin, Familial, Morular Metaplasia of the Endometrium, Childhood Non-Hodgkin Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Plerixafor is a selective antagonist of CXCR4 used for mobilization of hematopoietic stem cells (HSCs) for autologous stem cell transplantation (SCT) in patients with multiple myeloma (MM) and non-Hodgkin lymphoma (NHL).	19748593
Ischemia	Stem Cell Exhaustion	Impact of implanted bone marrow progenitor cell composition on limb salvage after cell implantation in patients with critical limb ischemia.	19748620
Anemia, Kidney Failure	Stem Cell Exhaustion	When compared with their control cohort, bone marrow cells from patients with advanced age, renal failure, or anemia had significantly less c-kit- and CD34-positive stem cells (P < .05) and showed significantly lower vascular endothelial growth factor production and colony-forming units in culture (P < .05).	19748631
Acute myocardial infarction	Stem Cell Exhaustion	Effects of exercise training on mobilization and functional activity of blood-derived progenitor cells in patients with acute myocardial infarction.	19748858
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Bi-directional activation between mesenchymal stem cells and CLL B-cells: implication for CLL disease progression.	19751240
Atherosclerosis, Diabetes Mellitus	Stem Cell Exhaustion	Effects of atorvastatin on circulating CD34+/CD133+/ CD45- progenitor cells and indices of angiogenesis (vascular endothelial growth factor and the angiopoietins 1 and 2) in atherosclerotic vascular disease and diabetes mellitus.	19754853
Disease	Stem Cell Exhaustion	A new bone marrow transplantation method for stem cell disorders.	19758228
Autoimmune Diseases	Stem Cell Exhaustion	Using animal models for autoimmune diseases, we have previously shown that allogeneic bone marrow transplantation (BMT) can be used to treat autoimmune diseases and that autoimmune diseases are hemopoietic stem cell (HSC) disorders.	19758228
Disease, Pulmonary Emphysema, Osteoporosis	Stem Cell Exhaustion	Using this new method, we show that most age-associated diseases, such as osteoporosis and emphysema, are MSC disorders and, on the basis of this evidence, propose a new concept of stem cell disorders, including HSC and MSC disorders.	19758228
TG wt Allele	Stem Cell Exhaustion	Patient HSP70-hom TG haplotype is associated with decreased transplant-related mortality and improved survival after sibling HLA-matched hematopoietic stem cell transplantation.	19758266
Lesion of brain	Stem Cell Exhaustion	Granulocyte colony stimulating factor (GCSF) may boost physiological stem cell repair system in patients with cerebral lesions.	19765889
Supranuclear paralysis, Corticobasal degeneration, Multiple System Atrophy	Stem Cell Exhaustion	The effect of repeated administrations of granulocyte colony stimulating factor for blood stem cells mobilization in patients with progressive supranuclear palsy, corticobasal degeneration and multiple system atrophy.	19765889
Hypernatremia	Stem Cell Exhaustion	Iron overload in patients receiving allogeneic hematopoietic stem cell transplantation: quantification of iron burden by a superconducting quantum interference device (SQUID) and therapeutic effectiveness of phlebotomy.	19766730
Thalassemia, Hematological Disease	Stem Cell Exhaustion	Iron overload (IO) is a known adverse prognostic factor in patients who undergo allogeneic hematopoietic stem cell transplantation (HSCT) for thalassemia and appears to play a similar role in patients with other hematologic disorders.	19766730
Specialty Type - cancer, HIV Infections, Diabetes Mellitus, Communicable Diseases	Stem Cell Exhaustion	A control group was matched to the IFI group based on high-risk conditions (i.e., cancer, infection with human immunodeficiency virus, chronic obstructive pulmonary disease, diabetes mellitus, and solid-organ, hematopoietic stem cell, or bone marrow transplant), age, sex, and hospital region and teaching status.	19767376
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Relationship between tumor-infiltrating T lymphocytes and clinical response after reduced-intensity allogeneic hematopoietic stem cell transplantation for advanced renal cell carcinoma: a single center prospective study.	19770130
Refractory Cytopenia of Childhood	Stem Cell Exhaustion	However, because RCC is sensitive to cytokine therapy, an immunotherapeutic approach such as hematopoietic stem cell transplantation (HSCT) might lead to a cure.	19770130
CNS disorder, Pleural Effusion, CTCAE	Stem Cell Exhaustion	Those with CNS disease, pleural effusion, circulating lymphoma cells > or = 5,000/microL, or history of stem-cell transplant were ineligible.	19770379
altretamine/cisplatin/cyclophosphamide protocol	Stem Cell Exhaustion	Telomere shortening in patients with CHD could potentially be attributed to either inherited TL shortening or acquired accelerated telomere shortening restricted to the hematopoietic system, which affects the baseline TL of all peripheral blood cell populations, including peripheral blood stem cells and progenitor cells.	19770396
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We evaluated the number and clonogenic potential of bone marrow erythroid/myeloid/megakaryocytic progenitor cells using clonogenic assays, the apoptotic characteristics and adhesion molecule expression of CD34(+) cells by flow cytometry, the hematopoiesis-supporting capacity of bone marrow stromal cells using long-term bone marrow cultures and the number and activation status of peripheral blood lymphocytes in ten patients with low/intermediate-1 risk myelodysplastic syndrome with del(5q) receiving lenalidomide.	19773257
Stroma of bone marrow, Hypoplastic anemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	The beneficial effect of lenalidomide in patients with lower risk myelodysplastic syndrome with del(5q) is associated with significant increases in the proportion of bone marrow erythroid precursor cells and in the frequency of clonogenic progenitor cells, a substantial improvement in the hematopoiesis-supporting potential of bone marrow stroma and significant alterations in the adhesion profile of bone marrow CD34(+) cells.	19773257
Autoimmune Diseases	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation for autoimmune diseases: an observational study on 12 years' experience from the European Group for Blood and Marrow Transplantation Working Party on Autoimmune Diseases.	19773265
Autoimmune Diseases	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation has been used since 1996 for the treatment of severe autoimmune diseases refractory to approved therapies.	19773265
Autoimmune Diseases	Stem Cell Exhaustion	In this observational study we analyzed all first autologous hematopoietic stem cell transplants for autoimmune diseases reported to the European Group for Blood and Marrow Transplantation (EBMT) registry between 1996-2007.	19773265
Autoimmune Diseases	Stem Cell Exhaustion	Nine hundred patients with autoimmune diseases (64% female; median age, 35 years) who underwent a first autologous hematopoietic stem cell transplant were included.	19773265
Autoimmune Diseases	Stem Cell Exhaustion	This largest cohort studied worldwide shows that autologous hematopoietic stem cell transplantation can induce sustained remissions for more than 5 years in patients with severe autoimmune diseases refractory to conventional therapy.	19773265
Autoimmune Diseases	Stem Cell Exhaustion	These data support ongoing and planned phase III trials to evaluate the place of autologous hematopoietic stem cell transplantation in the treatment strategy for severe autoimmune diseases.	19773265
Moyamoya Disease	Stem Cell Exhaustion	Decreased level and defective function of circulating endothelial progenitor cells in children with moyamoya disease.	19774676
Myocardial Ischemia	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPCs) play an important role in physiological and pathological neovascularization and may be involved in attenuating ischemic diseases.	19774676
Acute lymphocytic leukemia	Stem Cell Exhaustion	In the process of family screening to locate a donor for hematopoietic stem cell transplantation, the younger sibling was found to have hypocellular bone marrow and later developed acute lymphoblastic leukemia.	19779378
PAFAH1B1 wt Allele, Mastocytosis, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are a group of heterogeneous clonal stem cell diseases with a tendency to progress to leukemic transformation.	19781444
Communicable Diseases	Stem Cell Exhaustion	Human parainfluenza virus 3 (HPIV3) infection can cause significant morbidity and mortality in patients undergoing hematopoietic stem cell transplantation (HSCT).	19781656
Specialty Type - cancer	Stem Cell Exhaustion	The preventive health behaviors of long-term survivors of cancer and hematopoietic stem cell transplantation compared with matched controls.	19781657
Cholangiolocellular Carcinoma	Stem Cell Exhaustion	Cholangiolocellular carcinoma (CoCC) is currently considered to originate from hepatic progenitor cells.	19781883
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Determinants of functional performance in long-term survivors of allogeneic hematopoietic stem cell transplantation with chronic graft-versus-host disease (cGVHD).	19784078
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	This study examined factors accounting for functional performance limitations in 100 long-term survivors of allogeneic hematopoietic stem cell transplantation with chronic graft-versus-host disease (cGVHD).	19784078
Neoplasms	Stem Cell Exhaustion	As another theory, it is possible for this tumor to originate from the pluripotent stem cells in the stomach.	19784744
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Two large studies compared posaconazole and fluconazole or itraconazole for prophylaxis in subjects undergoing allogeneic hematopoietic stem cell transplantation or subjects with acute myelogenous leukemia.	19786600
Pancreatic Ductal Adenocarcinoma, Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	We examined the expression pattern of the cell surface marker CD133, which has been used to identify putative cancer stem cells from solid tumors, in adult pancreatic ductal adenocarcinomas (n = 10) and IPMNs (n = 34).	19786935
Pterygium	Stem Cell Exhaustion	The limbus and its stem cells are important in the pathogenesis of pterygium.	19787589
Pterygium	Stem Cell Exhaustion	In this study, the usefulness of limbal stem cells and conjunctival autograft transplantation for the treatment of primary pterygium is assessed.	19787589
Pterygium	Stem Cell Exhaustion	In this prospective noncomparative cohort study, 42 eyes of 42 patients with grade I-III primary pterygium underwent pterygium excision followed by superotemporal limbal stem cells and conjunctival autograft transplantation.	19787589
Pterygium	Stem Cell Exhaustion	Although limbal stem cells and conjunctival autograft transplantation is a time-consuming procedure, it is a safe and effective technique for the treatment of different grades of pterygium.	19787589
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Reserves, functional, immunoregulatory, and cytogenetic properties of bone marrow mesenchymal stem cells in patients with myelodysplastic syndromes.	19788374
PAFAH1B1 wt Allele	Stem Cell Exhaustion	The aim of this study is to explore whether the BM stroma progenitors, namely the mesenchymal stem cells (MSCs), are primarily affected in MDS by evaluating the reserves, the functional properties, as well as the cytogenetic characteristics, in comparison to BM hematopoietic cells, in patients with de novo MDS (n = 13).	19788374
Electrocardiogram: myocardial infarction (finding), Ventricular Remodeling, Acute myocardial infarction, Infarction	Stem Cell Exhaustion	Intracoronary infusion of bone marrow-derived mononuclear cells abrogates adverse left ventricular remodelling post-acute myocardial infarction: insights from the reinfusion of enriched progenitor cells and infarct remodelling in acute myocardial infarction (REPAIR-AMI) trial.	19789401
Multiple Myeloma	Stem Cell Exhaustion	Clonotypic B lymphocytes expressing CD34, but not CD19, were identified in stem cell harvests from patients with myeloma and could represent progenitor cells of neoplastic plasma cells.	19792049
Multiple Myeloma	Stem Cell Exhaustion	Harvests of cryopreserved peripheral blood stem-cells from 20 myeloma patients were enriched for clonotypic B lymphocytes.	19792049
Mycoses	Stem Cell Exhaustion	Voriconazole is safe and effective as prophylaxis for early and late fungal infections following allogeneic hematopoietic stem cell transplantation.	19793068
Hollings Cancer Center, Neoplasms	Stem Cell Exhaustion	Paediatric HCC has a morphology different from adult HCC, sometimes resembling HB, and a larger proportion of paediatric tumours have progenitor cell features.	19793197
Malignant neoplasm of liver	Stem Cell Exhaustion	Hepatic progenitor cells in liver cancers from Asian children.	19793197
Hollings Cancer Center	Stem Cell Exhaustion	HB and HCC in children may represent malignant transformation at an early stage in the cellular lineage and often arise from hepatic progenitor cells.	19793197
Lymphoma, Follicular, Lymphoma	Stem Cell Exhaustion	Matched unrelated donor stem cell transplant in 131 patients with follicular lymphoma: an analysis from the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation.	19793383
Lymphoma, Follicular	Stem Cell Exhaustion	Matched unrelated donor stem cell transplantation (MUD-SCT) provides the only curative option for patients with follicular lymphoma (FL) who fail conventional therapies and do not have a sibling donor.	19793383
Specialty Type - cancer, Primary malignant neoplasm	Stem Cell Exhaustion	Numb protein expression correlates with a basal-like phenotype and cancer stem cell markers in primary breast cancer.	19795205
Malignant neoplasm of breast, Neoplasms	Stem Cell Exhaustion	The aim of this study was to investigate the relationship between Numb protein expression and clinicopathological characteristics, tumor biological subtypes and putative cancer stem cell markers in a well-characterized cohort of primary human breast cancers.	19795205
Specialty Type - cancer, Primary Neoplasm	Stem Cell Exhaustion	We further established an inverse correlation between the Numb expression levels and the CD44+/CD24- cancer stem cell phenotype (P = 0.05) in primary tumors.	19795205
Aggressive behavior, Specialty Type - cancer, Primary malignant neoplasm	Stem Cell Exhaustion	Taken together, our results indicate that loss of Numb expression is a marker of tumor aggressiveness, potentially linked to BRCA1 status and a cancer stem cell phenotype in primary breast cancer.	19795205
Neoplasms	Stem Cell Exhaustion	Progressive telomere shortening limits stem cell divisions and probably acts as a tumor suppressor mechanism.	19796246
Premature tooth loss, Malignant Neoplasms	Stem Cell Exhaustion	We have found heritable hypomorphic TERT mutations in other cancers as well, and we propose that such mutations result in short telomeres and premature loss of stem cells.	19796246
Multiple Myeloma	Stem Cell Exhaustion	The prevalence of an abnormal serum free light chain (FLC) ratio in 34 patients with multiple myeloma in complete response (CR) after hematopoietic stem cell transplantation was studied.	19797521
Malignant neoplasm of stomach	Stem Cell Exhaustion	We identified three oncogenic pathways (proliferation/stem cell, NF-kappaB, and Wnt/beta-catenin) deregulated in the majority (>70%) of gastric cancers.	19798449
Periodontitis	Stem Cell Exhaustion	Increased levels of circulating endothelial progenitor cells in subjects with moderate to severe chronic periodontitis.	19799717
Periodontitis	Stem Cell Exhaustion	The purpose of this study was to determine the association between chronic periodontitis (CP) and circulating endothelial progenitor cells (EPC).	19799717
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Hematopoietic stem cell transplantation for refractory or recurrent non-Hodgkin lymphoma in children and adolescents.	19800015
Burkitt Lymphoma, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	We examined the role of hematopoietic stem cell transplantation (HSCT) for patients aged< or =18 years with refractory or recurrent Burkitt (n=41), lymphoblastic (n=53), diffuse large B cell (DLBCL; n=52), and anaplastic large cell lymphoma (n=36), receiving autologous (n=90) or allogeneic (n=92; 43 matched sibling and 49 unrelated donor) HSCT in 1990-2005.	19800015
Precursor cell lymphoblastic lymphoma	Stem Cell Exhaustion	Allogeneic donor HSCT was more likely to use irradiation-containing conditioning regimens, bone marrow (BM) stem cells, be performed in more recent years, and for lymphoblastic lymphoma.	19800015
Specialty Type - cancer, Communicable Diseases	Stem Cell Exhaustion	To determine the prevalence of infection of HBV in children with cancer who have undergone chemotherapy or have had a hematopoietic stem cell transplant.	19802418
Dilated Cardiomyopathy Pathway	Stem Cell Exhaustion	A pilot trial to assess potential effects of selective intracoronary bone marrow-derived progenitor cell infusion in patients with nonischemic dilated cardiomyopathy: final 1-year results of the transplantation of progenitor cells and functional regeneration enhancement pilot trial in patients with nonischemic dilated cardiomyopathy.	19808371
Myocardial Ischemia	Stem Cell Exhaustion	Intracoronary administration of bone marrow-derived progenitor cells (BMC) was shown to improve coronary microvascular function in ischemic heart disease.	19808371
Primary Myelofibrosis, leukemia	Stem Cell Exhaustion	Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: a prospective, multicenter study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation.	19812383
Primary Myelofibrosis, Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase, Thrombocythemia, Essential	Stem Cell Exhaustion	From 2002 to 2007, 103 patients with primary myelofibrosis or postessential thrombocythemia and polycythemia vera myelofibrosis and a median age of 55 years (range, 32-68 years) were included in a prospective multicenter phase 2 trial to determine efficacy of a busulfan (10 mg/kg)/fludarabine (180 mg/m(2))-based reduced-intensity conditioning regimen followed by allogeneic stem cell transplantation from related (n = 33) or unrelated donors (n = 70).	19812383
Primary cutaneous CD30+ T-cell lymphoproliferative disorder	Stem Cell Exhaustion	Primary cutaneous T-cell lymphoproliferative disorder of donor origin after allogeneic haematopoietic stem-cell transplantation.	19817764
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Stem Cell Exhaustion	A 56-year-old male patient had a history of mantle-cell lymphoma, which was treated with polychemotherapy and reduced-intensity conditioning allogeneic haematopoietic stem cell transplantation (ASCT) from his healthy sister with an identical human leucocyte antigen profile.	19817764
leukemia	Stem Cell Exhaustion	Aldehyde dehydrogenase activity among primary leukemia cells is associated with stem cell features and correlates with adverse clinical outcomes.	19819294
leukemia	Stem Cell Exhaustion	Animal models have provided evidence for the existence of leukemia stem cells (LSC).	19819294
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Superior survival after replacing oral with intravenous busulfan in autologous stem cell transplantation for non-Hodgkin lymphoma with busulfan, cyclophosphamide and etoposide.	19821828
Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) with cyclophosphamide, etoposide and oral busulfan (BuCyVP) is an effective therapy for relapsed or refractory non-Hodgkin lymphoma (NHL).	19821828
Prostate carcinoma	Stem Cell Exhaustion	Immunohistochemical expression of prostate stem cell antigen in cystoprostatectomies with incidental prostate cancer.	19822092
Prostate carcinoma	Stem Cell Exhaustion	High expression of prostate stem cell antigen (PSCA) has been shown to be associated with adverse prognostic features in clinically-diagnosed prostate cancer.	19822092
Failure, Multiple Myeloma	Stem Cell Exhaustion	Failure to achieve a threshold dose of CD34+CD110+ progenitor cells in the graft predicts delayed platelet engraftment after autologous stem cell transplantation for multiple myeloma.	19822297
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	To predict platelet engraftment more accurately post autologous stem cell transplantation (SCT), we retrospectively analyzed the CD34(+)CD110(+) (CD110 or c-mpl, thrombopoietin receptor) content in the grafts of 70 patients undergoing transplantation for multiple myeloma (MM) with an in-house flow cytometric assay.	19822297
Acute lymphocytic leukemia	Stem Cell Exhaustion	Reduced-intensity conditioning followed by peripheral blood stem cell transplantation for adult patients with high-risk acute lymphoblastic leukemia.	19822300
BCR gene	Stem Cell Exhaustion	We conducted a retrospective study of 24 high-risk adult ALL patients who received an RIC regimen of fludarabine (Flu)/melphalan (Mel) prior to allogeneic peripheral blood stem cell transplantation (PBSCT) between 6/14/02 and 6/15/07 at the City of Hope.	19822300
Graft-vs-Host Disease, Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Randomized controlled trials and an individual patient data meta-analysis (IPDMA) have demonstrated a decreased risk of disease relapse and an increased risk of acute and chronic graft-versus-host disease (aGVHD, cGVHD) in patients receiving PBSCs compared with those receiving BM stem cells.	19822301
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Quantifying the survival benefit for allogeneic hematopoietic stem cell transplantation in relapsed acute myelogenous leukemia.	19822303
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HSCT) is the recommended therapy for patients with relapsed acute myelogenous leukemia (AML), despite little evidence showing a survival benefit in patients who undergo HSCT versus chemotherapy alone.	19822303
neurological complication	Stem Cell Exhaustion	Early and late neurological complications after reduced-intensity conditioning allogeneic stem cell transplantation.	19822304
neurological complication	Stem Cell Exhaustion	Neurological complications (NC) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) are common and life-threatening in most cases.	19822304
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Busulfan and cyclophosphamide (Bu/Cy) as a preparative regimen for autologous stem cell transplantation in patients with non-Hodgkin lymphoma: a single-institution experience.	19822305
Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	High-dose chemotherapy with autologous stem cell transplantation (ASCT) has been established as a standard form of therapy for patients with non-Hodgkin lymphoma (NHL).	19822305
B-Cell Lymphomas	Stem Cell Exhaustion	Impact of pre-transplant rituximab on survival after autologous hematopoietic stem cell transplantation for diffuse large B cell lymphoma.	19822306
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Despite this progress, however, many patients develop refractory or recurrent DLBCL and then undergo autologous hematopoietic stem cell transplantation (AuHCT).	19822306
Primary hypogonadism	Stem Cell Exhaustion	Hematopoietic stem-cell transplantation (HSCT) is associated with high rates of gonadal failure, which is distressing for younger patients desiring to start a family.	19822307
Deep Vein Thrombosis	Stem Cell Exhaustion	Batroxobin mobilizes circulating endothelial progenitor cells in patients with deep vein thrombosis.	19825915
Hodgkin Disease	Stem Cell Exhaustion	[Autologous stem cell transplantation in patients with relapsed or refractory Hodgkin's disease].	19827348
Hodgkin Disease, HD Term Type	Stem Cell Exhaustion	Patients with relapsed or refractory Hodgkin's disease (HD) are routinely treated with intensive chemotherapy followed by autologous stem cell transplantation (ASCT).	19827348
Chronic Kidney Diseases, Chronic Kidney Disease, CTCAE	Stem Cell Exhaustion	Reported data regarding chronic kidney disease (CKD) in haematopoietic stem cells transplantation (HSCT) recipients are highly discrepant.	19828460
Adult Glioblastoma, Specialty Type - cancer	Stem Cell Exhaustion	We established a cancer stem (CS) cell line, U87CS, by means of spheroid culture of U87MG cells derived from glioblastoma (GBM) in neuronal stem cell medium.	19832037
Adult Glioblastoma, Specialty Type - cancer	Stem Cell Exhaustion	Enhanced MDR1 expression and chemoresistance of cancer stem cells derived from glioblastoma.	19832037
Epstein-Barr virus, Post-transplant lymphoproliferative disorder, Lymphoproliferative Disorders	Stem Cell Exhaustion	Epstein Barr viremia (EBV) and posttransplantation lymphoproliferative disorder (PTLD) are complications of hematopoietic stem cell transplantation (HSCT).	19835968
Graft-vs-Host Disease	Stem Cell Exhaustion	An age-dependent pharmacokinetic study of intravenous and oral mycophenolate mofetil in combination with tacrolimus for GVHD prophylaxis in pediatric allogeneic stem cell transplantation recipients.	19835971
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease (aGVHD) still remains a major limiting factor following allogeneic stem cell transplantation (AlloSCT) in pediatric recipients.	19835971
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease (aGVHD) limits the effectiveness of allogeneic hematopoietic stem cell transplantation.	19838066
Graft-vs-Host Disease	Stem Cell Exhaustion	Early-onset lichenoid graft-vs.-host disease: a unique variant of acute graft-vs.-host disease occurring in peripheral blood stem cell transplant recipients.	19843195
Graft-vs-Host Disease, Scleroderma	Stem Cell Exhaustion	A complication of stem cell transplantation is chronic graft-vs.-host disease (GvHD), developing months to years after transplant; the two commonest manifestations are lichenoid GvHD and scleroderma.	19843195
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Inhibiting mammalian target of rapamycin (mTOR) signaling in acute myelogenous leukemia (AML) blasts and leukemic stem cells may enhance their sensitivity to cytotoxic agents.	19843663
Cessation of life, Mycoses	Stem Cell Exhaustion	Time trends in fungal infections as a cause of death in hematopoietic stem cell transplant recipients: an autopsy study.	19846817
Cessation of life	Stem Cell Exhaustion	Infectious complications remain an important cause of death in hematopoietic stem cell transplant (HSCT) recipients.	19846817
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic graft-versus-host disease (cGVHD) is a common and potentially lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT).	19848412
Malignant Peripheral Nerve Sheath Tumor, Myeloproliferative disease	Stem Cell Exhaustion	Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by proliferation of one or more myeloid cell lineages.	19850737
Muscular Dystrophy, Infiltration	Stem Cell Exhaustion	Our data should provide valuable insights into the mechanisms that control muscle stem cell differentiation and into the mechanism of metaplasia observed in aging or muscular dystrophy where adipose infiltration of muscle occurs.	19851509
Childhood Breast Carcinoma	Stem Cell Exhaustion	To determine whether dose-intensive adjuvant regimens for breast cancer induce genetic damage to hematopoietic stem cells, defined by the emergence of clonal hematopoiesis, and whether detection of clonal hematopoiesis could be used as an early marker for the subsequent development of t-MN, the Southwest Oncology Group designed a pilot clonality investigation to estimate the incidence of clonal hematopoiesis during and shortly after completion of the dose intensive neoadjuvant regimens for high-risk breast cancer patients.	19851858
Pruritus senilis	Stem Cell Exhaustion	[Effect of guishen zhiyang recipe for treatment of patients with senile pruritus of blood-deficiency and Gan-hyperactive syndrome type and its impact on stem cell factor and dynorphin].	19852293
Pruritus senilis, Stem Cell Factor	Stem Cell Exhaustion	To explore the mechanism of Chinese medicinal therapy for nourishing blood and softening Gan in treating senile pruritus through observing the impact of Guishen Zhiyang Recipe (GZR) on serum levels of stem cell factor (SCF) and dynorphin (DYN) in patients suffered from the disease of blood-deficiency and Gan-hyperactive syndrome type (BDGH).	19852293
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Little is known about aberrant methylation in myelodysplastic syndrome (MDS), a heterogeneous clonal stem cell disorder with a approximately 30% risk of transformation into secondary AML.	19853913
Mikulicz Disease, Multiple Myeloma, Decreased platelet count	Stem Cell Exhaustion	Mikulicz's disease with severe thrombocytopenia following autologous stem cell transplantation in a multiple myeloma patient.	19856041
Mikulicz Disease, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We report the first case of Mikulicz's disease (MD) occurring 2 years after autologous peripheral blood stem cell transplantation (PBSCT) for multiple myeloma (MM).	19856041
Decreased cardiac function	Stem Cell Exhaustion	In this Canadian randomized, double-blind, placebo-controlled, Phase I-II study ("COMPARE-AMI"), we are evaluating the feasibility, safety, and efficacy of intracoronary injection of selected CD133+ stem cells for cardiac repair in patients with impaired cardiac function after successfully stented acute MI.	19857748
Diarrhea, Fever	Stem Cell Exhaustion	The list of covariates tested included age; body weight; body height; gender; posaconazole dose; race; coadministration of antineoplastic chemotherapy; day of stem cell transplantation; concomitant ranitidine, pantoprazole, cyclosporine, or tacrolimus administration; coincident fever; diarrhea; and plasma gamma-glutamyltransferase activity.	19858252
Diarrhea, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	A 40-year-old man undergoing allo-hematopoietic stem cell transplantation for chronic myelogenous leukemia and developing diarrhea was administered prophylactic antibiotics including levofloxacin, fluconazole, cotrimoxazole, and vancomycin.	19860258
B-Cell Lymphomas, Central Nervous System	Stem Cell Exhaustion	Disease status at autologous stem cell transplantation and the cell of origin phenotype are important predictors of outcome in patients with neurologic (central nervous system) relapse of diffuse large B-cell lymphoma undergoing autologous stem cell transplantation.	19860614
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	We present a retrospective analysis of patients with neurological relapse of DLBCL and correlate the outcome according to the disease stage at autologous stem cell transplantation (ASCT) and the cell of origin phenotype.	19860614
Hemopoietic stem cell transplant	Stem Cell Exhaustion	Total parenteral nutrition (TPN) is still of great importance for haematopoietic stem cell transplantation (HSCT) patients because one of the major adverse effects of the high-dose therapy followed by HSCT is an inadequate oral nutrition intake.	19860986
Pancreatic carcinoma	Stem Cell Exhaustion	[Role of prostate stem cell antigen in human pancreatic carcinoma: a tissue microarray-based study].	19861285
Pancreatic carcinoma	Stem Cell Exhaustion	To investigate the expression of prostate stem cell antigen (PSCA) in human pancreatic carcinoma and explore its role in the oncogenesis of pancreatic cancer.	19861285
Multiple Myeloma	Stem Cell Exhaustion	Retrospective comparison of mobilization methods for autologous stem cell transplantation in multiple myeloma.	19862826
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The combination of cyclophosphamide and granulocyte-colony stimulating factor (G-CSF) has widely been used to mobilize hematopoietic stem cells (HSCs) for autologous stem cell transplantation (ASCT) for multiple myeloma (MM).	19862826
Hematologic Neoplasms	Stem Cell Exhaustion	Sensitivity was slightly lower among patients with hematologic malignancy or stem cell transplantation.	19863452
Renal function	Stem Cell Exhaustion	After 6 years, deterioration of kidney function occurred and autologous stem cell transplantation was considered, but the patient refused specific therapies.	19863884
LACRIMAL DUCT DEFECT, Renal function	Stem Cell Exhaustion	This case, documented by repeated biopsies, demonstrates the very slow loss of kidney function, suggesting the possibility of conservative treatment strategies without taking the risks of chemotherapy or autologous stem cell transplantation, since no long term follow up data of these therapies are available for LCDD.	19863884
Chronic granulomatous disease, Aspergillosis	Stem Cell Exhaustion	Treosulfan-based conditioning regimen in a second matched unrelated peripheral blood stem cell transplantation for a pediatric patient with CGD and invasive aspergillosis, who experienced initial graft failure after RIC.	19866337
Juvenile Myelomonocytic Leukemia	Stem Cell Exhaustion	To evaluate minimal residual disease (MRD) after chemotherapy and haematopoietic stem cell transplantation in juvenile myelomonocytic leukaemia (JMML), a locked nucleic acid-allele specific quantitative polymerase chain reaction (LNA-AS-qPCR) was developed for 13 patients (four types of PTPN11 mutation and four types of RAS mutation).	19874312
Osteoporosis	Stem Cell Exhaustion	Circulating mesenchymal stem cells with abnormal osteogenic differentiation in patients with osteoporosis.	19877060
Osteoporosis	Stem Cell Exhaustion	Several genes contribute to normal osteoblastic differentiation from mesenchymal stem cells (MSCs), but an understanding of their role in the pathogenesis of osteoporosis is still lacking.	19877060
Peripheral Blood Stem Cells, Thrombotic Microangiopathies	Stem Cell Exhaustion	Thrombotic microangiopathy during peripheral blood stem cell mobilization.	19877288
Anemia, Decreased platelet count	Stem Cell Exhaustion	During stem cell mobilization with GCSF, she developed worsening of anemia; thrombocytopenia and worsening of renal function.	19877288
Hematological Disease	Stem Cell Exhaustion	Therefore we hypothesized that there should be a quantitative and qualitative relationship between MSC colonies (CFU-F) and hematopoietic stem cell colonies (colony-forming unit-granulocyte-macrophages; CFU-GM) among patients with and without hematologic diseases.	19878078
Hematological Disease	Stem Cell Exhaustion	The clonogenic potential of hematopoietic stem cells and mesenchymal stromal cells in various hematologic diseases: a pilot study.	19878078
Hematological Disease	Stem Cell Exhaustion	This is the first study that has compared the clonogenic potential of stromal cells and hematopoietic stem cells in the same subjects with and without hematologic diseases.	19878078
Communicable Diseases	Stem Cell Exhaustion	However, stem cells are difficult to transport in culture media without risk of contamination, infection and reduced viability.	19878080
Metapneumovirus	Stem Cell Exhaustion	Human metapneumovirus infection in hematopoietic stem cell transplant recipients.	19878491
Respiratory Tract Infections, Communicable Diseases	Stem Cell Exhaustion	The objective of this study was to identify hMPV as the etiological agent of acute respiratory infection in hematopoietic stem cell transplant (HSCT) patients and to determine the clinical features of hMPV infection in these patients.	19878491
Antilymphocyte Serum	Stem Cell Exhaustion	Stem cell therapy therefore has been proposed as an alternative therapy for ALS.	19879334
Antilymphocyte Serum	Stem Cell Exhaustion	These data suggest that intrathecal injection with an optimized cell number could be a potential route for stem cell therapy in ALS patients.	19879334
Antilymphocyte Serum	Stem Cell Exhaustion	Dose-dependent efficacy of ALS-human mesenchymal stem cells transplantation into cisterna magna in SOD1-G93A ALS mice.	19879334
Antilymphocyte Serum	Stem Cell Exhaustion	In this study, we evaluated the dose-dependent effects of human bone marrow mesenchymal stem cells (hMSCs) obtained from an ALS patient (ALS-hMSCs) on SOD1 mice via intrathecal injection and showed its practicality for hMSCs.	19879334
Mantle cell lymphoma	Stem Cell Exhaustion	Immunologic recovery following autologous stem-cell transplantation with pre- and posttransplantation rituximab for low-grade or mantle cell lymphoma.	19880437
Mantle cell lymphoma	Stem Cell Exhaustion	Seventy-seven patients with low-grade or mantle cell lymphoma received autologous stem-cell transplantation (ASCT) on a phase II study.	19880437
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The median age of the patients was 56 (range 18-70) y. Nineteen patients received therapy for acute myeloid leukaemia and 51 patients received autologous stem cell transplantation.	19883163
Lymphopenia, Hematopoietic stem cells, B-Cell Lymphomas	Stem Cell Exhaustion	New-onset lymphopenia assessed during routine follow-up is a risk factor for relapse postautologous peripheral blood hematopoietic stem cell transplantation in patients with diffuse large B-cell lymphoma.	19883776
Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	A specific predictor during routine follow-up to ascertain risk for postautologous peripheral blood hematopoietic stem cell transplantation (post-APHSCT) relapse in non-Hodgkin lymphoma (NHL) has not been identified.	19883776
Multiple Myeloma	Stem Cell Exhaustion	Bortezomib and high-dose melphalan as conditioning regimen before autologous stem cell transplantation in patients with de novo multiple myeloma: a phase 2 study of the Intergroupe Francophone du Myelome (IFM).	19884643
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) is recommended for younger patients with newly diagnosed multiple myeloma.	19884643
leukemia	Stem Cell Exhaustion	We evaluated gender, age, location, GS antedating leukemia, underlying disorders, treatment type and stem cell transplantation.	19887783
Liver Cirrhosis, Hepatitis B	Stem Cell Exhaustion	Expression of contactin associated protein-like 2 in a subset of hepatic progenitor cell compartment identified by gene expression profiling in hepatitis B virus-positive cirrhosis.	19889080
GDC Disease Response Terminology	Stem Cell Exhaustion	Hepatic progenitor cells (HPC), a cell compartment capable of differentiating into hepatocytic and biliary lineages, may give rise to the formation of intermediate hepatobiliary cells (IHBC) or ductular reactions (DR).	19889080
Myelosuppression, Hypothyroidism	Stem Cell Exhaustion	The cRIT-salvage regimen was well tolerated, notable for myelosuppression minimized by stem cell support (n = 5), and biochemical hypothyroidism (n = 5).	19890606
Acute myocardial infarction	Stem Cell Exhaustion	Effect of intracoronary injection of mononuclear bone marrow stem cells on left ventricular function in patients with acute myocardial infarction.	19892047
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	To investigate the effect of intracoronary injection of autologous mononuclear bone marrow stem cells (BMSCs) in patients with ST-elevation myocardial infarction (STEMI) on left ventricular (LV) systolic and diastolic function using standard echocardiography and 2-dimensional systolic strain.	19892047
Graft-vs-Host Disease	Stem Cell Exhaustion	Although he received allogeneic peripheral blood stem cell transplantation after the first remission, he died 9 months after the initial diagnosis due to relapse of the disease and graft-versus-host disease.	19893346
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Isolated extramedullary relapse with involvement of the breasts by acute myeloid leukemia (AML) after allogeneic stem cell transplantation is an uncommon event.	19893411
Xerostomia	Stem Cell Exhaustion	Xerostomia and chronic oral complications among patients treated with haematopoietic stem cell transplantation.	19893563
Xerostomia	Stem Cell Exhaustion	To assess the severity of xerostomia (subjective dry mouth) in haematopoietic stem cell transplantation (HSCT) patients and to investigate the association of xerostomia with other chronic oral complications.	19893563
Pfaundler-Hurler Syndrome	Stem Cell Exhaustion	As intravenously administered enzyme cannot cross the blood-brain barrier, the therapy of choice for the more severe Hurler syndrome is haematopoietic stem cell transplantation (HCT).	19894140
Graft-vs-Host Disease	Stem Cell Exhaustion	Up to 50% of patients undergoing allogenic stem cell transplantation or bone marrow transplantation (BMT) can develop acute or chronic graft versus host disease (GVHD) as a severe complication.	19894371
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	We show that the reduction in hematopoietic and endothelial progenitor cells correlates with COPD severity.	19895908
Pertussis	Stem Cell Exhaustion	Pertussis immunity and response to tetanus-reduced diphtheria-reduced pertussis vaccine (Tdap) after autologous peripheral blood stem cell transplantation.	19896077
Pertussis	Stem Cell Exhaustion	This study assessed pertussis titers in 57 adult survivors of an autologous peripheral blood stem cell transplantation (PBSCT; median age, 37.5 years), 28 of whom were subsequently vaccinated with Tdap containing 2.5microg of PT (Adacel).	19896077
Mycoses	Stem Cell Exhaustion	Incidence of Viral and fungal infections following busulfan-based reduced-intensity versus myeloablative conditioning in pediatric allogeneic stem cell transplantation recipients.	19896083
Neutropenia, Bacteremia	Stem Cell Exhaustion	Reductions in the duration and nadir of neutropenia have translated into a significant decrease in bacteremia in adult recipients of allogeneic stem cell transplantation (allo-SCT) with reduced-intensity conditioning (RIC) during the first 30 days after transplantation.	19896083
Glioblastoma Multiforme Pathway, Specialty Type - cancer, Malignant Glioma	Stem Cell Exhaustion	Although the concept of cancer stem cells reveals a new framework of cancer therapeutic strategies against malignant glioma, it remains unclear how glioma stem cells could be eradicated.	19896441
Ischemia	Stem Cell Exhaustion	Intraoperative adjunctive stem cell treatment in patients with critical limb ischemia using a novel point-of-care device.	19896796
CLU protein, human, Ischemia	Stem Cell Exhaustion	In a prospective trial we tested whether adjunctive intraoperative stem cell treatment in patients with critical limb ischemia (CLI) can be performed safely in combination with bypass surgery and/or interventional treatment.	19896796
Malignant neoplasm of lung	Stem Cell Exhaustion	Circulating endothelial progenitor cells are increased in human lung cancer and correlate with stage of disease.	19896859
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	Recent studies suggest that circulating endothelial progenitor cells (cEPCs) are recruited to the angiogenic vascular system of non-small-cell lung cancer (NSCLC) and correlate with clinical behaviour.	19896859
Neoplasms	Stem Cell Exhaustion	The potential applications of human neural progenitor cells (hNPCs) are wide ranging, but a normal cytogenetic profile is important to avoid the risk of tumor formation in clinical trials.	19898616
Toxic nephropathy	Stem Cell Exhaustion	Long-term renal toxicity in children following fractionated total-body irradiation (TBI) before allogeneic stem cell transplantation (SCT).	19899009
Renal dysfunction	Stem Cell Exhaustion	To retrospectively assess the incidence and time course of renal dysfunction in children (< or = 16 years) following total- body irradiation (TBI) before allogeneic stem cell transplantation (SCT).	19899009
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Vaccines are attractive as consolidation therapy after autologous stem cell transplantation (ASCT) for multiple myeloma (MM).	19899131
Hematologic Neoplasms	Stem Cell Exhaustion	Low-dose total body irradiation and fludarabine conditioning for HLA class I-mismatched donor stem cell transplantation and immunologic recovery in patients with hematologic malignancies: a multicenter trial.	19900571
Amyotrophic Lateral Sclerosis	Stem Cell Exhaustion	Telomerase activity and expression in adult human mesenchymal stem cells derived from amyotrophic lateral sclerosis individuals.	19903097
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Prognostic impact of pre-transplantation transfusion history and secondary iron overload in patients with myelodysplastic syndrome undergoing allogeneic stem cell transplantation: a GITMO study.	19903678
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	The relative impact of these factors on the outcome of patients with myelodysplastic syndrome receiving allogeneic stem-cell transplantation remains to be clarified.	19903678
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Pre-transplantation transfusion history and serum ferritin have significant prognostic value in patients with myelodysplastic syndrome undergoing myeloablative allogeneic stem cell transplantation, inducing a significant increase of non-relapse mortality.	19903678
Thyroid Diseases	Stem Cell Exhaustion	TR gene expression at the mRNA and protein levels in human CD34(+)-enriched haematopoietic progenitor cells (HPCs) obtained from the peripheral blood of patients with thyroid disorders and healthy volunteers was analysed.	19903799
Endothelial dysfunction	Stem Cell Exhaustion	These findings suggest that low HDL cholesterol is an independent risk factor for endothelial dysfunction and that pravastatin improves endothelial function in individuals with isolated low HDL cholesterol through, at least in part, an increase in circulating progenitor cells.	19903864
Acute myelomonocytic leukemia	Stem Cell Exhaustion	A 56-year-old woman with acute myelomonocytic leukemia underwent myeloablative allogeneic hematopoietic stem cell transplantation (allo-SCT) from a matched unrelated donor in her first complete remission (CR).	19904520
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Determinants of functional recovery after myocardial infarction of patients treated with bone marrow-derived stem cells after thrombolytic therapy.	19910293
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	To assess the determinants of functional recovery in patients with ST-elevation myocardial infarction (STEMI) treated initially with thrombolysis, followed by percutaneous coronary intervention and intracoronary injection of bone marrow-derived stem cells (BMC).	19910293
Specialty Type - cancer	Stem Cell Exhaustion	A serious dichotomy currently exists in hematopoietic stem cell transplantation (HSCT) and cancer research.	19911448
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	In recent years, a significant improvement in haematopoietic stem cell transplantation (HSCT) procedures in patients with high-risk CLL has been observed.	19911856
Persistent CMV viremia	Stem Cell Exhaustion	Relationship of reconstituted adaptive and innate cytomegalovirus (CMV)-specific immune responses with CMV viremia in hematopoietic stem cell transplant recipients.	19911937
Cytomegalovirus Infections	Stem Cell Exhaustion	Thirty-eight allogeneic hematopoietic stem cell transplant recipients at risk of CMV disease were prospectively monitored using whole blood CMV-DNA polymerase chain reaction assay, lymphocyte proliferation assay (LPA), interferon gamma enzyme-linked immunospot assay (ELISPOT), and flow cytometric enumeration of CMV-specific CD69+interferon (IFN)gamma+CD4, CD8, natural killer cells, and gammadelta T cells.	19911937
Persistent CMV viremia	Stem Cell Exhaustion	To our knowledge, this is the first study to prospectively compare multiple measures of innate and adaptive immune responses in hematopoietic stem cell transplant recipients with CMV viremia.	19911937
Viremia	Stem Cell Exhaustion	The strongest immune correlates with protection against CMV viremia in hematopoietic stem cell transplant recipients are reconstitution of CMV-specific T cell memory responses (LPA) and recovery of natural killer cell function.	19911937
Peripheral Blood Stem Cells	Stem Cell Exhaustion	Here, we report on a case of a 30-month-old girl with LAD-I, in whom peripheral blood stem cell from a genotypically identical sibling resulted in mixed chimerism.	19912557
Graft-vs-Host Disease	Stem Cell Exhaustion	Extended mycophenolate mofetil administration beyond day 30 in allogeneic hematopoietic stem cell transplantation as preemptive therapy for severe graft-versus-host disease.	19917404
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	To prevent acute graft-versus-host disease (GVHD), mycophenolate mofetil (MMF) combined with calcineurin inhibitors have been used in allogeneic hematopoietic stem cell transplantation (allo-SCT).	19917404
Mycosis Fungoides	Stem Cell Exhaustion	[Long-term efficacy of autologous stem cell transplantation for stage IV mycosis fungoides].	19917433
Mycosis Fungoides	Stem Cell Exhaustion	We report the case of a young man still in complete remission for transformed mycosis fungoides 14 years after autologous stem cell transplantation.	19917433
Lymphadenopathy, Neoplasms, Neurologic Symptoms, Aggressive behavior	Stem Cell Exhaustion	Because of tumour aggressiveness, autologous stem cell transplantation was performed and resulted in rapid regression of the tumours, lymphadenopathy and neurological symptoms.	19917433
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Stem Cell Exhaustion	Immunochemotherapy and autologous stem-cell transplantation for untreated patients with mantle-cell lymphoma: CALGB 59909.	19917845
Medial collateral ligament	Stem Cell Exhaustion	We explored the feasibility, safety, and effectiveness of an aggressive immunochemotherapy treatment program that included autologous stem-cell transplantation (ASCT) for patients up to age 69 years with newly diagnosed MCL.	19917845
Disease, Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer precursor/progenitor cells may initiate and sustain the growth of tumors, but evidence for their existence in human disease is indirect, relying on their in vitro properties and animal models.	19922650
Malignant Neoplasms	Stem Cell Exhaustion	This outcome supports the presence of a rare population of precursor/progenitor cells in human malignancies, and suggests benefit from their removal.	19922650
Inflammation, Fever	Stem Cell Exhaustion	After allogeneic stem cell transplantation, a 49-year-old man developed fever and inflammation at the site of a plant puncture on a finger.	19923491
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Patients (pts) with fulminant progression (FPG) of multiple myeloma (MM) after autologous stem cell transplantation (ASCT) have poor prognosis.	19924414
Neurocytoma	Stem Cell Exhaustion	Treatment of atypical central neurocytoma in a child with high dose chemotherapy and autologous stem cell rescue.	19924515
Neurocytoma	Stem Cell Exhaustion	The authors describe a 9 month old female with recurrent atypical central neurocytoma and leptomeningeal spread treated with high dose chemotherapy, autologous stem cell rescue, and adjuvant therapy.	19924515
Neurocytoma	Stem Cell Exhaustion	The use of intensive chemotherapy followed by autologous stem cell rescue for atypical neurocytoma may be considered as an adjunct to surgical therapy in young patients with atypical neurocytoma not amenable to radiation therapy.	19924515
atherosclerotic	Stem Cell Exhaustion	During atherosclerotic progression, a stable fraction of leukocytes represented mast cells (6%) and CD117-positive cells as potential progenitor cells (1%).	19926495
Heart failure	Stem Cell Exhaustion	[Association between the number of peripheral blood stem cells and cardiac function index in patients with ischemic heart failure].	19927627
Heart failure	Stem Cell Exhaustion	To observe the association between the number of peripheral blood stem cells (PBSC) and cardiac function index (NYHA grade, left ventricular ejection fraction, LVEF, N-terminal-proB-type Natriuretic Peptide, NT-pro BNP) in patients with ischemic heart failure (IHF).	19927627
Hemorrhage	Stem Cell Exhaustion	We analysed in three cohorts of 100 patients each treated with allogeneic hematopoietic stem cell transplantation (HSCT), autologous HSCT, and intensive chemotherapy, respectively, whether treatment with these drugs was associated with an increased risk of bleeding.	19929239
Coronary Lesions Treated, Coronary Restenosis	Stem Cell Exhaustion	Genous endothelial progenitor cell capturing stent vs. the Taxus Liberte stent in patients with de novo coronary lesions with a high-risk of coronary restenosis: a randomized, single-centre, pilot study.	19933225
Coronary Lesions Treated, Coronary Restenosis	Stem Cell Exhaustion	The purpose of this study was to evaluate the Genous(TM) endothelial progenitor cell capturing stent vs. the Taxus Liberte paclitaxel-eluting stent in patients with de novo coronary lesions with a high-risk of coronary restenosis.	19933225
Mycoses	Stem Cell Exhaustion	Voriconazole is used to manage invasive fungal diseases in recipients of an allogeneic haematopoietic stem cell transplant (HSCT) after myeloablative treatment.	19933691
Respiratory Syncytial Virus Infections	Stem Cell Exhaustion	Respiratory syncytial virus infection in recipients of allogeneic stem-cell transplantation: a retrospective study of the incidence, clinical features, and outcome.	19935377
Respiratory Tract Infections	Stem Cell Exhaustion	Respiratory syncytial virus (RSV) is a common cause of serious respiratory infections in hematopoietic stem-cell transplant (HSCT) recipients.	19935377
Sinus Tachycardia	Stem Cell Exhaustion	Inappropriate sinus tachycardia after hematopoietic stem cell transplantation.	19935431
Specialty Type - cancer, Abnormal cardiac conduction	Stem Cell Exhaustion	Survivors of childhood cancer and hematopoietic stem cell transplantation are subject to a range of cardiac late effects including conduction abnormalities.	19935431
Inappropriate sinus tachycardia, Acute lymphocytic leukemia	Stem Cell Exhaustion	We present, the case of a 12-year-old girl diagnosed with inappropriate sinus tachycardia after a history of multiply relapsed acute lymphoblastic leukemia and an exposure history including anthracycline-based chemotherapy followed by the total body irradiation in the context of a hematopoietic stem cell transplant.	19935431
Huntington Disease	Stem Cell Exhaustion	Slowed progression in models of Huntington disease by adipose stem cell transplantation.	19938161
Nocardia, Opportunistic Infections	Stem Cell Exhaustion	Nocardia pseudobrasiliensis as an emerging cause of opportunistic infection after allogeneic hematopoietic stem cell transplantation.	19940053
Pneumonia	Stem Cell Exhaustion	We report the case of a 55-year-old man who exhibited a nodular pneumonia 4 months after an allogeneic hematopoietic stem cell transplantation.	19940053
Neoplasms	Stem Cell Exhaustion	Three bioinformatics-verified miRNA-128 targets, angiopoietin-related growth factor protein 5 (ARP5; ANGPTL6), a transcription suppressor that promotes stem cell renewal and inhibits the expression of known tumor suppressor genes involved in senescence and differentiation, Bmi-1, and a transcription factor critical for the control of cell-cycle progression, E2F-3a, were found to be up-regulated.	19941032
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Impact of pre-transplant serum ferritin on outcomes of patients with myelodysplastic syndromes or secondary acute myeloid leukaemia receiving reduced intensity conditioning allogeneic haematopoietic stem cell transplantation.	19944463
Neoplasm Metastasis	Stem Cell Exhaustion	The putative stem cell marker CD24 is a small, heavily glycosylated, cell surface molecule which was originally associated with tumour metastasis.	19946098
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	MiR-125b is critical for the suppression of human U251 glioma stem cell proliferation.	19948152
Glioblastoma Multiforme Pathway, Negative Regulation of Cell Cycle	Stem Cell Exhaustion	Further research on the mechanism demonstrated that inhibition of miR-125b-induced U251 glioma stem cell proliferation was due to cell cycle arrest at the G1/S transition and involved the cell cycle regulated proteins CDK6 and CDC25A; miR-125b overexpression decreased CDK6 and CDC25A expression.	19948152
Glioblastoma Multiforme Pathway, insensitivity, Glioma	Stem Cell Exhaustion	Given the insensitivity of gliomas to chemotherapy and the hypothesis that glioma stem cells cause resistance to drug therapy, exploring the functions and mechanisms of miR-125b in glioma stem cells would be valuable.	19948152
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	In this study, we found that miR-125b was downregulated in human U251 glioma stem cells, therefore suggesting that its upregulation can lead to the growth inhibition of U251 glioma stem cells in vitro.	19948152
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	These findings underscore the potential of miR-125b to regulate the proliferation of U251 glioma stem cells through the cell cycle regulated proteins CDK6 and CDC25A.	19948152
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	It is generally assumed that plasma cells from multiple myeloma (MM) patients do not express the stem cell marker CD34.	19948206
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	busulfan (Bu) is well tolerated and effective in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) for acute myelogenous leukemia (AML).	19948235
Diabetic Retinopathy	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) mobilized and activated by neurotrophic factors may contribute to pathologic neovascularization in diabetic retinopathy.	19948824
Lymphoma	Stem Cell Exhaustion	Other studies have suggested that ferritin is a surrogate for advanced disease and has an impact on relapse, because elevated serum ferritin predicts overall survival (OS) and relapse-free survival following autologous stem cell transplantation for lymphomas.	19949737
Nasal Type Extranodal NK/T-Cell Lymphoma	Stem Cell Exhaustion	Successful treatment of refractory advanced nasal NK/T cell lymphoma with unrelated cord blood stem cell transplantation incorporating focal irradiation.	19949902
Precursor cell lymphoblastic lymphoma	Stem Cell Exhaustion	[Comparison of the efficiency of CHOP-based regimen with or without high dose consolidation treatment combined with hematopoietic stem cell transplantation in 63 lymphoblastic lymphoma patients].	19950562
Precursor cell lymphoblastic lymphoma	Stem Cell Exhaustion	To retrospectively analyze and compare the treatment efficiency of CHOP-based regimens with or without high-dose consolidation treatment combined with hematopoietic stem cell transplantation (HDT-HSCT) in the patients with lymphoblastic lymphoma (LBL).	19950562
Specialty Type - cancer, Neoplasms, Ductal Breast Carcinoma	Stem Cell Exhaustion	We have examined the possible correlation between cancer stem cell (CSC)-like markers (CD133, paired box gene 2 protein (PAX2), epithelial specific antigen (ESA)), and a new membrane estrogen receptor (G-protein coupled receptor 30 (GPR30)) in invasive ductal breast carcinomas with known clinicopathological parameters, tumor recurrence, and expression of some known biomarkers.	19951611
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation (autoSCT) has an important role in the treatment of patients with symptomatic multiple myeloma (MM).	19951883
Hodgkin Disease	Stem Cell Exhaustion	Brazilian experience using high-dose sequential chemotherapy followed by autologous hematopoietic stem cell transplantation for relapsed or refractory Hodgkin lymphoma.	19951885
DHDDS gene	Stem Cell Exhaustion	HDS consisted of the sequential administration of cyclophosphamide and granulocyte colony-stimulating factor with stem cell harvesting, followed by methotrexate plus vincristine and etoposide.	19951885
Atrial Fibrillation by ECG Finding	Stem Cell Exhaustion	Relationship of circulating endothelial progenitor cells to the recurrence of atrial fibrillation after successful conversion and maintenance of sinus rhythm.	19951966
Cardiac Arrhythmia, Atrial Fibrillation, Atrial Fibrillation by ECG Finding	Stem Cell Exhaustion	To determine whether the number of circulating endothelial progenitor cells (EPCs) in patients with persistent atrial fibrillation (AF) predicts arrhythmia recurrence after direct current cardioversion (DCCV).	19951966
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Factors predicting long-term survival after T-cell depleted reduced intensity allogeneic stem cell transplantation for acute myeloid leukemia.	19951968
Embryonal Carcinoma	Stem Cell Exhaustion	Pluripotent embryonal carcinomas (EC) are the malignant counterparts to embryonic stem cells and are considered the stem cells of TGCTs.	19951990
Multiple Myeloma	Stem Cell Exhaustion	[Pelvic and spinal MR follow-up of multiple myeloma patients after high-dose chemotherapy and autologous peripheral blood stem cell transplant].	19953058
Bone Marrow, Multiple Myeloma	Stem Cell Exhaustion	To evaluate the changes of bone marrow lesions on pelvic and spinal MR in patients with multiple myeloma after high-dose chemotherapy and autologous peripheral blood stem cell transplant.	19953058
Disease	Stem Cell Exhaustion	Human induced pluripotent stem cells (IPSCs) have enormous potential in the development of cellular models of human disease and represent a potential source of autologous cells and tissues for therapeutic use.	19956585
melanoma	Stem Cell Exhaustion	The stem cell marker nestin predicts poor prognosis in human melanoma.	19956860
melanoma, Specialty Type - cancer	Stem Cell Exhaustion	The cancer stem cell hypothesis suggests that mutated melanocyte stem cells are present in skin as precursors of melanoma cells.	19956860
melanoma	Stem Cell Exhaustion	The aim of this study was to establish if melanocytic stem cells could have a prognostic significance in melanoma progression.	19956860
Aggressive behavior, S100A4 protein, human, Carcinoma	Stem Cell Exhaustion	Polycomb-group proteins Bmi1 is regarded as a "stemness" gene involved in the maintenance of stem cells, malignant transformation, and biologic aggressiveness of several human carcinomas.	19957112
Peripheral Blood Stem Cells, Heart failure, Syndrome	Stem Cell Exhaustion	[Relationship between Chinese medicine syndrome and peripheral blood stem cells in patients with ischemic heart failure].	19960976
Heart failure	Stem Cell Exhaustion	To explore the relationship of Chinese medicine syndromes with heart function and peripheral blood stem cells (PBSCs) count in patients with ischemic heart failure (IHF).	19960976
Up	Stem Cell Exhaustion	Our data indicate that mean diffusivity (MD) values increase continuously from HC through a-MCI to AD in the bilateral SVZ, where most of the proliferating stem cells in the adult brain are located.	19962428
MICROPHTHALMIA, SYNDROMIC 7, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukemias (AMLs) result from multiple genetic alterations in hematopoietic stem cells.	19965692
Squamous metaplasia	Stem Cell Exhaustion	The presence of goblet cells on the surface of corneas with squamous metaplasia grade 1, in a significant number of patients, suggests that limbal stem cell deficiency is a common condition associated with advanced cases of BK.	19965819
Small cell carcinoma of lung, Adenocarcinoma	Stem Cell Exhaustion	Therapeutic procedures employed were surgery in 3 cases of adenocarcinoma and a high dose chemotherapy (HDC) with autologous peripheral blood stem cell transplantation (APBSCT) in 1 case of SCLC.	19994601
Myeloid neoplasm	Stem Cell Exhaustion	Within an ongoing prospective phase II trial, 22 patients with advanced myeloid malignancies and a median age of 65 years (range 54-76) received anti-CD66 Rhenium radioimmunotherapy followed by fludarabine (150 mg/m(2)), busulfan (8 mg/kg) and alemtuzumab (75 mg) before allogeneic haematopoietic stem cell transplantation from matched sibling (n = 7) and unrelated donors (n = 15).	19995390
Acute myocardial infarction	Stem Cell Exhaustion	Clinical outcome 2 years after intracoronary administration of bone marrow-derived progenitor cells in acute myocardial infarction.	19996415
Acute myocardial infarction	Stem Cell Exhaustion	The aim of this study was to investigate the clinical outcome 2 years after intracoronary administration of autologous progenitor cells in patients with acute myocardial infarction (AMI).	19996415
Infarction	Stem Cell Exhaustion	Using a double-blind, placebo-controlled, multicenter trial design, we randomized 204 patients with successfully reperfused AMI to receive intracoronary infusion of bone marrow-derived progenitor cells (BMC) or placebo medium into the infarct artery 3 to 7 days after successful infarct reperfusion therapy.	19996415
Graft-vs-Host Disease	Stem Cell Exhaustion	Interleukin-17-producing T-helper cells as new potential player mediating graft-versus-host disease in patients undergoing allogeneic stem-cell transplantation.	19996925
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GVHD) is a major obstacle to safe allogeneic hematopoietic stem-cell transplantation, leading to significant mortality.	19996925
Malignant neoplasm of brain, Medulloblastoma	Stem Cell Exhaustion	Contemporary protocols for the treatment of malignant brain tumors such as medulloblastoma (MB) in children, often involve craniospinal irradiation (CSI) at diagnosis followed by serial courses of high dose chemotherapy and autologous hematopoietic stem cell support.	19998469
Medulloblastoma	Stem Cell Exhaustion	Successful mobilization, harvest and transplant of peripheral blood stem cells using AMD3100 and G-CSF following high dose craniospinal irradiation for medulloblastoma in a young child.	19998469
Malignant Neoplasms	Stem Cell Exhaustion	Thiotepa/topotecan/carboplatin with autologous stem cell rescue in recurrent/refractory/poor prognosis pediatric malignancies of the central nervous system.	19998470
Multiple Myeloma	Stem Cell Exhaustion	Bortezomib plus dexamethasone can improve stem cell collection and overcome the need for additional chemotherapy before autologous transplant in patients with myeloma.	20001242
Specialty Type - cancer	Stem Cell Exhaustion	Our clinical trial at Memorial Sloan-Kettering Cancer Center builds on a 20-year long investigation to develop an erythroid-specific vector to regulate beta-globin transgene expression in the progeny of transduced hematopoietic stem cells.	20001625
Urinary Stress Incontinence	Stem Cell Exhaustion	Periurethral injection of autologous adipose-derived stem cells for the treatment of stress urinary incontinence in patients undergoing radical prostatectomy: report of two initial cases.	20002225
Urinary Incontinence, CTCAE 5.0, Urethral Sphincters, Urinary Stress Incontinence	Stem Cell Exhaustion	To report a novel cell therapy using autologous adipose tissue-derived stem cells (ADSC) for stress urinary incontinence caused by urethral sphincteric deficiency and the outcomes in two initial cases undergoing periurethral injection of stem cells for the treatment of urinary incontinence after radical prostatectomy.	20002225
Specialty Type - cancer, Hepatitis B	Stem Cell Exhaustion	Clinical and virological factors associated with hepatitis B virus reactivation in HBsAg-negative and anti-HBc antibodies-positive patients undergoing chemotherapy and/or autologous stem cell transplantation for cancer.	20002298
Hematologic	Stem Cell Exhaustion	All were treated for haematological cancer, 3/7 received haematopoietic stem cell transplantation (HSCT), and 4/7 received rituximab.	20002298
Epithelial metaplasia, Inflammation	Stem Cell Exhaustion	Epithelial metaplasia is a phenomenon where a native mucosal cell type is replaced by another due to altered stem cell differentiation, usually as the result of long-standing injury or inflammation.	20003139
Childhood Breast Carcinoma	Stem Cell Exhaustion	Breast cancer cells with the CD44(+)/CD24(-) phenotype have been associated with stem cell properties.	20004947
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	In conclusion, our findings challenge the proposed role of CD44(+)/CD24(-) cells as cancer stem cells in tumor resistance to chemotherapy as they apparently are not selected by conventional cytotoxic agents.	20004947
melanoma, Neoplasms	Stem Cell Exhaustion	CD133 is recognised as a stem cell marker and is capable of identifying a tumour-initiating subpopulation in brain, colon, melanoma and other solid tumours.	20005089
Specialty Type - cancer, Neoplasms, Secondary Neoplasm, leukemia	Stem Cell Exhaustion	Cancer stem cells have been isolated and expanded from leukaemia and several solid tumours, and have been associated with metastasis, chemoresistance and relapse.	20005089
Multiple Myeloma	Stem Cell Exhaustion	Herein we have described a 39-year-old Caucasian man with a history of immunoglobulin G-kappa multiple myeloma who failed two chemotherapy regimens, but ultimately responded to the combination of thalidomide, bortezomib, and dexamethasone followed by high-dose melphalan and autologous stem cell transplantation 3 years prior to transplantation, during which time he showed no evidence of persistent or recurrent disease.	20005409
Primary Myelofibrosis	Stem Cell Exhaustion	Allogeneic stem cell transplantation for myelofibrosis with leukemic transformation.	20005966
Lymphotoxin-Alpha, human, Primary Myelofibrosis	Stem Cell Exhaustion	We hypothesized that allogeneic stem cell transplantation (ASCT) can improve outcomes for patients with LT, and reviewed 55 consecutive patients that were treated for myelofibrosis with ASCT at our institution.	20005966
Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria: long-term results of a retrospective study on behalf of the Gruppo Italiano Trapianto Midollo Osseo (GITMO).	20007144
Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria is an acquired clonal disorder of the hemopoietic stem cells for which the only curative treatment is allogeneic hematopoietic stem cell transplantation.	20007144
Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	The aim of this retrospective study was to assess the long-term clinical and hematologic results in 26 paroxysmal nocturnal hemoglobinuria patients who received hematopoietic stem cell transplantation in Italy between 1988 and 2006.	20007144
Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	The findings of this study confirm that most patients with paroxysmal nocturnal hemoglobinuria may be definitively cured with hematopoietic stem cell transplantation.	20007144
MYELODYSPLASTIC SYNDROME, Secondary Acute Myeloid Leukemia	Stem Cell Exhaustion	Allogeneic hematopoietic stem-cell transplantation for patients 50 years or older with myelodysplastic syndromes or secondary acute myeloid leukemia.	20008642
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Allogeneic hematopoietic stem-cell transplantation remains a potential curative therapeutic option for many older patients with MDS.	20008642
B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1	Stem Cell Exhaustion	The prognosis of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+)ALL) relapsing after allogeneic hematopoietic stem cell transplantation is dismal.	20009435
Polycythemia Vera, Primary Myelofibrosis	Stem Cell Exhaustion	Successful treatment with reduced-intensity stem cell transplantation for secondary myelofibrosis following polycythemia vera.	20009439
Acquired Immunodeficiency Syndrome	Stem Cell Exhaustion	Successful treatment with autologous peripheral blood stem cell transplantation for acquired immunodeficiency syndrome (AIDS)-related malignant lymphoma.	20009441
infectious - Entity Risk, NCI CTEP SDC AIDS-related Lymphoma Sub-Category Terminology	Stem Cell Exhaustion	Because of the poor prognosis of AIDS-related lymphoma, he received autologous peripheral blood stem cell transplantation with the MEAM protocol (ranimustine, etoposide, cytarabine, melphalan) as a conditioning procedure without a severe infectious episode.	20009441
Neoplasms, leukemia	Stem Cell Exhaustion	Increased aldehyde dehydrogenase 1A1 (ALDH1A1) activity has been found in the stem cell populations of leukemia and some solid tumors.	20010854
Prostate carcinoma, Malignant neoplasm of prostate	Stem Cell Exhaustion	ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome.	20010854
Prostate carcinoma, Specialty Type - cancer, Passive Cutaneous Anaphylaxis	Stem Cell Exhaustion	Prostate cancer (PCa) contains a small population of cancer stem cells (CSCs) that contribute to its initiation and progression.	20010854
Childhood Breast Carcinoma	Stem Cell Exhaustion	Putative breast cancer stem cells might express surface markers such as aldehyde dehydrogenase 1 (ALDH1) and BMI-1 proteins.	20010944
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	CD133+ circulating haematopoietic progenitor cells predict for response to sorafenib plus erlotinib in non-small cell lung cancer patients.	20010948
Neoplasms	Stem Cell Exhaustion	Circulating endothelial cells (CECs) and haematopoietic progenitor cells (HPCs) might have a role in tumour angiogenesis and in tumour growth.	20010948
Amyloidosis	Stem Cell Exhaustion	Short and long-term outcome of treatment with high-dose melphalan and stem cell transplantation for multiple myeloma-associated AL amyloidosis.	20012043
Multiple Myeloma, Amyloidosis	Stem Cell Exhaustion	High-dose melphalan chemotherapy and autologous peripheral blood stem cell transplantation (HDM/SCT) has been shown to result in a durable hematologic response and prolonged overall survival in systemic amyloid light-chain (AL) amyloidosis as well as multiple myeloma.	20012043
diabetic	Stem Cell Exhaustion	In this chapter we describe the use of two potent gene transfer techniques to deliver the therapeutic gene extracellular superoxide dismutase (ecSOD) into the penis of aged or diabetic rats for therapy of ED: adenoviral-mediated intracavernosal ecSOD gene transfer for gene therapy of ED and ecSOD gene-modified marrow stromal cells, also known as mesenchymal stem cells, based stem cell and gene therapy.	20013181
Failure	Stem Cell Exhaustion	In addition, for the first time, a strictly defined uniform group of patients with total unilateral LSCD and no other significant ocular conditions has been used to allow the success or failure of treating LSCD to be attributable directly to the proposed stem cell therapy.	20014040
Endometrial Endometrioid Adenocarcinoma	Stem Cell Exhaustion	Increased epithelial stem cell traits in advanced endometrial endometrioid carcinoma.	20015385
Specialty Type - cancer	Stem Cell Exhaustion	It has been recognized cancer cells acquire characters reminiscent of those of normal stem cells, and the degree of stem cell gene expression correlates with patient prognosis.	20015385
Neoplasms	Stem Cell Exhaustion	Shared EpiSC genes in late EECs may contribute to the stem cell-like phenotypes shown by advanced tumors and hold the potential of being candidate therapeutic targets and novel prognosis biomarkers.	20015385
Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	Identifying genes shared between advanced tumors and stem cells will not only unmask the mechanisms of tumor malignancy but also provide novel therapeutic targets.	20015385
Multiple Sclerosis	Stem Cell Exhaustion	In multiple sclerosis lesions resident oligodendrocyte progenitor cells (OPCs) are present, but fail to remyelinate.	20016084
Malignant Glioma	Stem Cell Exhaustion	Platelet-derived growth factor BB mediates the tropism of human mesenchymal stem cells for malignant gliomas.	20023545
Glioblastoma Multiforme Pathway, Glioma	Stem Cell Exhaustion	Bone marrow-derived human mesenchymal stem cells (hMSCs) are capable of localizing to gliomas after systemic delivery and can be used in glioma therapy.	20023545
Specialty Type - cancer	Stem Cell Exhaustion	We have tested an approach to identify putative cancer stem cells that involves measurement of the infrared absorption spectrum of individual cells in an aqueous environment, and their subsequent classification using multivariate data analysis techniques.	20024181
Multiple Myeloma	Stem Cell Exhaustion	We again used the standard Prescrire methodology to review the latest data; (2) In patients who are symptomatic but who do not qualify for haematopoietic stem cell transplantation (especially people aged over 65), the results of five comparative trials suggest that adding thalidomide to the melphalan-prednisone combination delays myeloma progression by an additional 5 to 10 months.	20025098
Myocardial dysfunction	Stem Cell Exhaustion	In the 3rd stage, a clinical trial of stem cell implantation in patients with severe myocardial dysfunction involved injection of peripheral blood-derived endothelial precursor cells in 11 patients and autologous bone marrow mononuclear cells in 29.	20026532
Haiti	Stem Cell Exhaustion	The 19 patients who had HT were treated with curative intent: Nine patients received high-dose therapy with subsequent autologous stem cell transplantation (ASCT), and 10 patients received different chemotherapy regimens.	20029973
Amyotrophic Lateral Sclerosis	Stem Cell Exhaustion	Bone marrow-derived stromal cells from amyotrophic lateral sclerosis patients have diminished stem cell capacity.	20030561
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The objective of study was to primarily explore the efficacy of combination of high doses cytarabine, fludarabine and G-CSF (FLAG) as the consolidation therapy for patients with acute myeloid leukemia (AML), and to analyze the influence of FLAG on peripheral stem cell mobilization.	20030951
Toxic effect, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	It is concluded that as consolidation regimen, the FLAG is an effective and well-tolerated treatment in AML with acceptable toxicity, and may not influence the peripheral stem cell mobilization for autologous stem cell transplantation after 2 courses of FLAG.	20030951
Muscular Atrophy	Stem Cell Exhaustion	Embryonic stem cell-derived neural stem cells improve spinal muscular atrophy phenotype in mice.	20032086
Muscular Atrophy	Stem Cell Exhaustion	We previously showed that primary neural stem cells derived from spinal cord can ameliorate the spinal muscular atrophy phenotype in mice, but this primary source has limited translational value.	20032086
Muscular Atrophy	Stem Cell Exhaustion	In addition, following their intrathecal transplantation into spinal muscular atrophy mice, the neural stem cells, like those derived from spinal cord, survived and migrated to appropriate areas, ameliorated behavioural endpoints and lifespan, and exhibited neuroprotective capability.	20032086
melphalan/prednisone protocol	Stem Cell Exhaustion	Since the patient refrained from more intensive therapy, including autologous stem cell transplantation (auto-SCT), he was treated with vertebral irradiation and included in an institutionally guided study which randomized melphalan, prednisone (MP)-lenalidomide (MPR) to MP alone.	20032430
Medial collateral ligament	Stem Cell Exhaustion	Sustained MR during the postinduction period was predictive for outcome in MCL Younger after autologous stem cell transplantation (ASCT; RD at 2 years 100% vs 65%, P = .001) and during maintenance in MCL Elderly (RD at 2 years: 76% vs 36%, P = .015).	20032498
Histogenic Process, Neoplasms	Stem Cell Exhaustion	The histogenesis of GPG most likely involves proliferation and differentiation of pluripotent stem cells in the duodenal crypts in the duodenum as a true tumor, although it is also possible that the retroperitoneal components of both GCs and SCs proliferate, together with ECs, from ventral primordial tissue of the pancreas in the duodenum.	20033372
Opportunistic Infections	Stem Cell Exhaustion	HAART can lead to a successful hematopoietic stem cell transplantation without severe opportunistic infections.	20033800
Leukoencephalopathy, Autosome, Arteriopathic disease, Infarction	Stem Cell Exhaustion	Bone marrow-derived progenitor cells in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.	20035077
NOTCH3 wt Allele	Stem Cell Exhaustion	Our objective in this study was to evaluate endothelial progenitor cells and CPCs role in CADASIL.	20035077
NOTCH3 wt Allele	Stem Cell Exhaustion	Endothelial progenitor cells were significantly lower in patients with CADASIL than in control subjects (CD34/KDR: 0.05 versus 0.1 cells/microL, P=0.005; CD133/KDR: 0.07 versus 0.1 cells/microL, P=0.006; CD34/CD133/KDR: 0.05 versus 0.1 cells/microL, P=0.001).	20035077
NOTCH3 wt Allele, Endothelial dysfunction	Stem Cell Exhaustion	We have documented an association between endothelial progenitor cells and CPCs and CADASIL, extending previous data about the presence of endothelial dysfunction in this disease and its potential role in modulating phenotype.	20035077
Specialty Type - cancer	Stem Cell Exhaustion	A recent study has further suggested that ALDH1 may be considered to be a putative marker for HNSCC-derived cancer stem cells.	20036608
Leukemia, Myelocytic, Acute, Communicable Diseases	Stem Cell Exhaustion	The child had been included in pediatric acute myeloid leukemia trials as the parents were not ready for stem cell transplantation, but he died after 3 months due to overwhelming infection.	20037898
Multiple Myeloma	Stem Cell Exhaustion	Effects of induction with novel agents versus conventional chemotherapy on mobilization and autologous stem cell transplant outcomes in multiple myeloma.	20038230
Prostate carcinoma	Stem Cell Exhaustion	Prostate stem cell antigen mRNA in peripheral blood as a potential predictor of biochemical recurrence in high-risk prostate cancer.	20039280
Prostate carcinoma	Stem Cell Exhaustion	To determine whether the presence of prostate stem cell antigen (PSCA) mRNA in peripheral blood can predict biochemical recurrence (BCR) after radical prostatectomy in patients with high-risk prostate cancer.	20039280
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Correlation of pretransplant and early post-transplant response assessment with outcomes after reduced-intensity allogeneic hematopoietic stem cell transplantation for non-Hodgkin's lymphoma.	20041482
Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Chemotherapy sensitivity, defined simply as at least a partial response to chemotherapy, is an important outcome predictor for non-Hodgkin lymphoma (NHL) patients undergoing reduced-intensity allogeneic hematopoietic stem cell transplantation (allo-HCT).	20041482
Rheumatoid Arthritis	Stem Cell Exhaustion	Chondrogenic differentiation of human subchondral progenitor cells is impaired by rheumatoid arthritis synovial fluid.	20041492
Infection of bloodstream	Stem Cell Exhaustion	Comparison of fluorescence in situ hybridisation using peptide nucleic acid probes, Gram stain/acridine orange leukocyte cytospin and differential time to positivity methods for detection of catheter-related bloodstream infection in patients after haematopoietic stem cell transplantation.	20041887
Neutropenia, Infection of bloodstream	Stem Cell Exhaustion	In 46 febrile neutropenic patients who had undergone haematopoietic stem cell transplantation, the fluorescence in situ hybridisation using peptide nucleic acid probes (PNA FISH), Gram stain/acridine orange leukocyte cytospin (Gram/AOLC), and differential time to positivity (DTP) methods were performed for detection of catheter-related bloodstream infections (CRBSIs).	20041887
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Bone marrow (BM) stem cells improve cardiac function and outcome after acute ST-segment elevation myocardial infarction (MI).	20042424
Specialty Type - cancer	Stem Cell Exhaustion	CXCR4, CD133, CD44 and ABCG2 are representative transmembrane proteins expressed on the surfaces of normal and/or cancer stem cells.	20043076
Specialty Type - cancer	Stem Cell Exhaustion	Because CXCR4 is downregulated by p53-GFI1 signaling axis, p53 mutation in cancer stem cells leads to CXCR4 upregulation.	20043076
Primary Lesion, Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	Small molecule compound or human antibody targeted to CXCR4 will be applied for cancer therapeutics focusing on cancer stem cells at the primary lesion as well as metastasis or recurrence niches, such as bone marrow and peritoneal cavity.	20043076
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Stem cell transplantation is a potential treatment to improve left ventricular ejection fraction (LVEF) after ST elevation myocardial infarction (STEMI).	20043559
B-Cell Lymphomas, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	To evaluate the effect of rituximab in poor-prognosis patients with diffuse large B-cell lymphoma (DLBCL), a multicenter phase II trial combining rituximab with chemotherapy followed by high-dose therapy (HDT) with autologous stem cell transplant was conducted by the Groupe Ouest-Est des Leucemies et des Autres Maladies du Sang (GOELAMS).	20045738
Depression, CTCAE, Sleeplessness	Stem Cell Exhaustion	We assessed insomnia and depression, as well as concomitant corticosteroid (CS) administration, stem cell transplantation (SCT) therapy, and complications resulting from these therapies.	20045996
Colorectal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	When applied to several colorectal cancer data sets, parameter values consistent with crypt stem cell biology and normal mutation rates were able to match the increase in cancer with aging, and the mutation frequencies found in cancer genomes.	20051132
Specialty Type - cancer	Stem Cell Exhaustion	The analysis of this model yields a simple algebraic equation, which takes as inputs the number of stem cells, mutation and division rates, and the number of driver mutations, and makes predictions about cancer epidemiology.	20051132
Specialty Type - cancer	Stem Cell Exhaustion	The equation [p = 1 - (1 - (1 - (1 - u)d)k)Nm ] calculates the probability of cancer (p) and contains five parameters: the number of divisions (d), the number of stem cells (N x m), the number of critical rate-limiting pathway driver mutations (k), and the mutation rate (u).	20051132
Specialty Type - cancer	Stem Cell Exhaustion	APC mutations may shorten pathways to cancer by effectively increasing the numbers of stem cells at risk.	20051132
Diffuse alveolar hemorrhage	Stem Cell Exhaustion	Successful use of extracorporeal life support in a hematopoietic stem cell transplant patient with diffuse alveolar hemorrhage.	20051788
Diffuse alveolar hemorrhage	Stem Cell Exhaustion	To describe the successful use of extracorporeal life support in a hematopoietic stem cell transplant patient with diffuse alveolar hemorrhage.	20051788
Diffuse alveolar hemorrhage, Respiratory Failure, Pfaundler-Hurler Syndrome	Stem Cell Exhaustion	A 20-mo-old male with Hurler syndrome who developed respiratory failure from diffuse alveolar hemorrhage after hematopoietic stem cell transplant and was managed successfully with extracorporeal life support.	20051788
Diffuse alveolar hemorrhage, Pfaundler-Hurler Syndrome	Stem Cell Exhaustion	Diffuse alveolar hemorrhage is a well-known complication in hematopoietic stem cell transplant patients, with an even higher occurrence in those with Hurler syndrome.	20051788
Pulmonary hemorrhage	Stem Cell Exhaustion	Extracorporeal membrane oxygenation has been contraindicated traditionally in both pulmonary hemorrhage and hematopoietic stem cell transplant patients.	20051788
Diffuse alveolar hemorrhage	Stem Cell Exhaustion	We report the successful use of extracorporeal membrane oxygenation and survival to hospital discharge in a hematopoietic stem cell transplant patient with diffuse alveolar hemorrhage.	20051788
Hodgkin Disease, Childhood Burkitt Lymphoma	Stem Cell Exhaustion	In a later cohort of patients after hematopoietic stem cell transplantation, 4 of 7 patients with Hodgkin lymphoma or Burkitt lymphoma had EBV LMP1 detected.	20052729
Spinal Cord Injuries	Stem Cell Exhaustion	HPMA-RGD hydrogels seeded with mesenchymal stem cells improve functional outcome in chronic spinal cord injury.	20053128
Lesion	Stem Cell Exhaustion	We studied whether we can bridge a chronic spinal cord lesion by implantation of our newly developed hydrogel based on 2-hydroxypropyl methacrylamide, either alone or seeded with mesenchymal stem cells (MSCs), and whether this treatment leads to functional improvement.	20053128
Acute GVH disease	Stem Cell Exhaustion	Impact of cyclosporine-A concentration on the incidence of severe acute graft-versus-host disease after allogeneic stem cell transplantation.	20053329
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	This single-center retrospective study analyzed 85 consecutive patients who underwent allogeneic stem cell transplantation (allo-SCT) with the aim to assess whether there is a correlation between exposure to cyclosporine-A (CsA; as measured by CsA concentrations during the first month after allo-SCT) and the risk for developing severe grade III-IV acute graft-versus-host disease (aGVHD).	20053329
Acute Coronary Syndrome	Stem Cell Exhaustion	Differential levels of circulating progenitor cells in acute coronary syndrome patients with a first event versus patients with recurring events.	20053471
cytidylyl-(3-5)-cytidine	Stem Cell Exhaustion	We assessed inflammatory activation and circulating progenitor cells' (CPC) mobilisation in patients with a FCE versus those with RCE.	20053471
Hemorrhagic cystitis	Stem Cell Exhaustion	To validate this assay, urine samples from 124 renal transplant patients and serum samples from 18 hemorrhagic cystitis patients after hematopoietic stem cell transplantation were examined.	20053854
Childhood Breast Carcinoma, S100A4 protein, human	Stem Cell Exhaustion	We have hypothesized that breast cancer susceptibility loci may have a greater influence on breast cancer risk among women with higher birth weight, who are expected to have a larger pool of mammary stem cells that are susceptible to malignant transformation.	20054709
Premalignant, Specialty Type - cancer, precancerous lesions	Stem Cell Exhaustion	In order to develop useful diagnosis of pre-malignant lesions, expression of p53 family members and the cancer stem cell (CSCs) marker, CD44v6, were studied in histologically normal oral epithelium, precancerous lesions and succeeding invasive OSCCs.	20054805
Hepatitis B	Stem Cell Exhaustion	Resolved hepatitis B virus infection is not associated with worse outcome after allogeneic hematopoietic stem cell transplantation.	20056165
Hepatitis, Hepatitis B, Communicable Diseases	Stem Cell Exhaustion	Serologic evidence of resolved hepatitis B virus (HBV) infection has been associated with reactivation of hepatitis after allogeneic hematopoietic stem cell transplantation (allo-HSCT), but the true impact of this finding is unknown.	20056165
Hematopoietic stem cells, Aplastic Anemia	Stem Cell Exhaustion	The functional definition of aplastic anemia (AA) is the failure of hematopoietic stem cells to proliferate.	20058476
Melanosis	Stem Cell Exhaustion	Limbal stem cell deficiency after topical mitomycin C therapy for primary acquired melanosis with atypia.	20060167
Primary acquired melanosis	Stem Cell Exhaustion	To describe the incidence, characteristics, risk factors, and clinical outcome of limbal stem cell deficiency (LSCD) resulting from topical treatment with mitomycin C (MMC) for primary acquired melanosis (PAM) with atypia.	20060167
Hepatitis B	Stem Cell Exhaustion	Hepatitis B virus reactivation and efficacy of prophylaxis with lamivudine in patients undergoing allogeneic stem cell transplantation.	20060484
Multiple Myeloma	Stem Cell Exhaustion	Clinical impact and resource utilization after stem cell mobilization failure in patients with multiple myeloma and lymphoma.	20062089
Failure	Stem Cell Exhaustion	Failure to achieve optimal stem cell mobilization results in multiple subsequent attempts, which consumes large amounts of growth factors and potentially requires antibiotics and transfusions.	20062089
Hematologic Neoplasms	Stem Cell Exhaustion	We retrospectively reviewed the natural history of stem cell mobilization attempts at our institution from 2001 to 2007 to determine the frequency of suboptimal mobilization in patients with hematologic malignancy undergoing autologous transplant and analyzed the subsequent resource utilization in patients with initially failed attempts.	20062089
Specialty Type - cancer, Aspergillosis	Stem Cell Exhaustion	Caspofungin first-line therapy for invasive aspergillosis in allogeneic hematopoietic stem cell transplant patients: an European Organisation for Research and Treatment of Cancer study.	20062093
Neutropenia	Stem Cell Exhaustion	The high doses of chemotherapy used for the preparatory regimens before autologous blood or marrow stem cell transplantation leave patients at risk for neutropenic complications.	20062102
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease (GVHD) is a potentially fatal complication following allogeneic hematopoietic stem cell transplant.	20063098
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic stem cell transplantation versus chemotherapy as post-remission therapy for intermediate or poor risk adult acute myeloid leukemia: results of the JALSG AML97 study.	20063133
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We prospectively compared allogeneic hematopoietic stem cell transplantation (allo-HSCT) with chemotherapy as a post-remission therapy in a multicenter trial (JALSG AML97) of adult patients with intermediate or poor risk acute myeloid leukemia (AML).	20063133
Neoplasms, Glioblastoma	Stem Cell Exhaustion	Preliminary report on tumor stem cell/B cell hybridoma vaccine for recurrent glioblastoma multiforme.	20063522
Aggressive course, Neoplasms, Glioblastoma	Stem Cell Exhaustion	Glioblastoma multiforme (GBM), the most aggressive glioma, presents with a rapid evolution and relapse within the first year, which is attributed to the persistence of tumor stem cells (TSC) and the escape of immune surveillance.	20063522
Encephalitis, Neoplasms	Stem Cell Exhaustion	TSC vaccine consisting of TBH alone seems to have potent adjuvant reactions overcoming both persistence of tumor stem cells and immune escape of GBM without provoking an encephalitic reaction.	20063522
BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 20	Stem Cell Exhaustion	Reduction of both number and proliferative activity of human endothelial progenitor cells in obesity.	20065973
atherosclerotic, physiopathological	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPCs), responsible for neoangiogenesis and vascular repair, negatively correlate with vascular dysfunction and atherosclerotic risk factors.	20065973
Squamous cell carcinoma of vulva, Specialty Type - cancer	Stem Cell Exhaustion	Podoplanin, a mucin-type transmembrane glycoprotein, is thought to be one of the cancer stem cell markers for squamous-cell carcinoma of the vulva.	20066519
Specialty Type - cancer	Stem Cell Exhaustion	Because cancer stem-cell quantities have been reported to increase with chemotherapy and radiotherapy, cases in patients who did not receive such prior therapies were included in this study.	20066519
Extrapulmonary Small Cell Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	To examine whether podoplanin could be used as a cancer stem cell marker for ESCC, podoplanin-positive and podoplanin-negative fractions were sorted separately from the ESCC cell line and cultured.	20066519
Morular Metaplasia of the Endometrium, Multiple Myeloma, Waldenstrom Macroglobulinemia	Stem Cell Exhaustion	High-dose chemotherapy followed by autologous stem cell transplantation is the established treatment for symptomatic multiple myeloma (MM) or Waldenstrom macroglobulinemia (WM).	20066576
Toxic effect, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Our laboratory studies showed combined Bezafibrate and Medroxyprogesterone acetate (BaP) had activity against AML without toxicity to normal stem cells.	20067564
Multiple Myeloma	Stem Cell Exhaustion	Plerixafor (Mozobil) alone to mobilize hematopoietic stem cells from multiple myeloma patients for autologous transplantation.	20067838
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Unacylated ghrelin rescues endothelial progenitor cell function in individuals with type 2 diabetes.	20068135
Diabetes	Stem Cell Exhaustion	An altered UAG/AG profile together with an impairment of circulating endothelial progenitor cell (EPC) bioavailability were found in diabetes.	20068135
Colorectal Neoplasms	Stem Cell Exhaustion	Cultures of NIH-3T3 cells and human adipose-derived stem cells (hASC) were supplemented with samples of plasma from patients with K-ras-mutated colorectal tumors or from healthy subjects using two different protocols: direct addition of plasma to cultures in standard plates and addition in the absence of contact between plasma and cells, which were separated by a membrane with 0.4-mum pores.	20068178
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	High-dose chemotherapy supported by autologous peripheral blood stem cell transplantation (PBSCT) is beneficial for patients with relapsed or refractory but chemosensitive diffuse large B-cell lymphoma (DLBCL).	20068281
Memory impairment	Stem Cell Exhaustion	The memory deficit was paralleled by a decrease in the hippocampal stem cell pool and persistently reduced neurogenesis, subsequently causing a reduction in the number of dentate gyrus granule cell neurons in isoflurane-treated rats.	20068576
Memory impairment	Stem Cell Exhaustion	Isoflurane anesthesia induced persistent, progressive memory impairment, caused a loss of neural stem cells, and reduced neurogenesis in young, but not adult, rodents.	20068576
Specialty Type - cancer	Stem Cell Exhaustion	Late release of circulating endothelial cells and endothelial progenitor cells after chemotherapy predicts response and survival in cancer patients.	20072657
Myocardial Ischemia	Stem Cell Exhaustion	Transmyocardial laser revascularization combined with intramyocardial endothelial progenitor cell transplantation in patients with intractable ischemic heart disease ineligible for conventional revascularization: preliminary results in a highly selected small patient cohort.	20072970
Angina Pectoris, Myocardial Ischemia	Stem Cell Exhaustion	Transmyocardial laser revascularization for angina relief and intramyocardial autologous endothelial progenitor cell injection for neoangiogenesis may offer a new treatment strategy for patients with intractable ischemic heart disease.	20072970
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	In accord with the cancer stem cell (CSC) theory, only a small subset of cancer cells are capable of forming tumors.	20073073
NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology	Stem Cell Exhaustion	Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase.	20073073
Anemia, Polycystic Ovary Syndrome, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Pregnancy in a woman with polycystic ovary syndrome and myelodysplastic syndrome (in the form of refractory anemia) treated with allogeneic hemopoietic stem-cell transplantation (alloHSCT).	20074022
Specialty Type - cancer	Stem Cell Exhaustion	Endothelial progenitor cells are mobilized after major laparotomic surgery in patients with cancer.	20074467
Neoplasms	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPC) have the ability to form complete vascular structures in vitro and play a crucial role in tumor vasculogenesis.	20074467
Malignant Neoplasms	Stem Cell Exhaustion	Reduced-intensity conditioning hematopoietic stem cell transplantation in patients over 60 years: hematologic malignancy outcomes are not impaired in advanced age.	20074656
Graft-vs-Host Disease	Stem Cell Exhaustion	Genetic variations in the heparanase gene (HPSE) associate with increased risk of GVHD following allogeneic stem cell transplantation: effect of discrepancy between recipients and donors.	20075159
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GVHD) is the most common cause of nonrelapse mortality and morbidity after hematopoietic stem cell transplantation (HSCT).	20075159
Coronary Arteriosclerosis	Stem Cell Exhaustion	Evaluation of mobilized peripheral blood CD34(+) cells from patients with severe coronary artery disease as a source of endothelial progenitor cells.	20078384
Neoplasms	Stem Cell Exhaustion	[A preliminary study on the effects of feto-maternal microchimerism in activated human leukocyte antigen haploidentical mobilized peripheral blood stem cells on treatment of solid tumors].	20079231
Neoplasms	Stem Cell Exhaustion	HCCs also contained isolated tumor cell which expressed the same stem cell markers.	20080086
Liver carcinoma, Liver diseases	Stem Cell Exhaustion	The identification of stem cells in human liver diseases and hepatocellular carcinoma.	20080086
Liver neoplasms	Stem Cell Exhaustion	In the present study 69 liver biopsies and surgically excised liver tumors were studied for the presence of liver stem cells.	20080086
Liver carcinoma, Hollings Cancer Center	Stem Cell Exhaustion	It was found that human cirrhotic livers and hepatocellular carcinomas (HCC) frequently exhibited isolated single scattered hepatocyte stem cells within the liver parenchyma rather than in the portal tract, bile duct or the canal of Hering.	20080086
Liver carcinoma, HCCS gene	Stem Cell Exhaustion	Immunohistochemistry and RNA-FISH performed on human livers identified isolated stem cells in liver parenchyma as follows: Stem cells identified by immunohistochemical markers (OV-6 and GST-P) and RNA-FISH markers (HGF, EGF, CK19 and H19) were found scattered in the liver parenchyma of cirrhotic livers and within hepatocellular carcinomas (HCCs).	20080086
Fatty Liver Disease	Stem Cell Exhaustion	Precirrhotic ASH or NASH all stained negative for these stem cells.	20080086
Neoplasms	Stem Cell Exhaustion	In HCCs, 13 out of 15 had stem cells located within the tumor (78%).	20080086
Fatty Liver Disease, Alcoholic Steatohepatitis, Nonalcoholic Steatohepatitis	Stem Cell Exhaustion	Stem cells were found in 33% of HBV, 47% of HCV, 25% of alcoholic steatohepatitis (ASH) and 17% of non-alcoholic steatohepatitis (NASH).	20080086
Hollings Cancer Center	Stem Cell Exhaustion	The frequency of stem cells found in the different disease categories correlates with the frequency of HCC occurring in these different diseases.	20080086
Rheumatoid Arthritis, Calcification of coronary artery	Stem Cell Exhaustion	Role of circulating endothelial progenitor cells in patients with rheumatoid arthritis with coronary calcification.	20080904
Rheumatoid Arthritis, Atherosclerosis	Stem Cell Exhaustion	We hypothesize that depletion of circulating endothelial progenitor cells (EPC) related to RA can contribute to the development of atherosclerosis.	20080904
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Abnormal levels of circulating endothelial progenitor cells during exacerbations of COPD.	20082199
Cessation of life, Coronary Arteriosclerosis	Stem Cell Exhaustion	Reduced levels of circulating endothelial progenitor cells (EPCs) are associated with increased risk of death in patients with stable coronary artery disease (CAD).	20082199
Glioblastoma Multiforme Pathway, Cancer/Testis Antigen	Stem Cell Exhaustion	Enhanced expression of cancer testis antigen genes in glioma stem cells.	20082319
Specialty Type - cancer, Resistance Process	Stem Cell Exhaustion	Cancer stem cells are an important target for effective therapy, since they show tumorigenicity, chemoresistance, and radioresistance.	20082319
Glioblastoma Multiforme Pathway, Cancer/Testis Antigen, Specialty Type - cancer	Stem Cell Exhaustion	We isolated cancer stem cells from glioma cell lines and tissues and examined the expression of cancer testis antigen (CTA) genes as potential target molecules for cancer vaccine therapy.	20082319
Specialty Type - cancer	Stem Cell Exhaustion	CTA genes were highly and frequently expressed in cancer stem cells compared with differentiated cells.	20082319
Specialty Type - cancer	Stem Cell Exhaustion	In addition, histone acetylation levels in the promoter regions of CTA genes were high in cancer stem cells and low in differentiated cells, while DNA methylation analysis of the promoter regions revealed hypomethylation in cancer stem cells.	20082319
Specialty Type - cancer	Stem Cell Exhaustion	Moreover, the expression level of HLA class I antigens was not affected by the differentiation status, suggesting that CTA genes may present as surface antigens in cancer stem cells.	20082319
Glioblastoma Multiforme Pathway, Specialty Type - cancer	Stem Cell Exhaustion	Taken together, these findings suggest that CTA genes may be attractive candidates for targeted vaccine therapy against cancer stem cells in glioma patients.	20082319
Relapsing course	Stem Cell Exhaustion	Relapsed patients have a good prognosis, but refracter patients have long chance despite autolog or allogen hemopoietic stem cell transplantation.	20083465
Corneal Endothelial Cell Loss	Stem Cell Exhaustion	Progenitor cell outgrowth was shifted towards SPC with progression of endothelial damage.	20083473
Chronic Kidney Disease, CTCAE	Stem Cell Exhaustion	Progenitor cells and vascular function are impaired in patients with chronic kidney disease.	20083473
Atherosclerosis	Stem Cell Exhaustion	Bone marrow-derived endothelial progenitor cells (EPC) constitute an endogenous vascular repair system protecting against atherosclerosis.	20083473
Atherosclerosis	Stem Cell Exhaustion	Smooth muscle progenitor cells (SPC) may stimulate atherosclerosis development.	20083473
Chronic Kidney Diseases, Endothelial dysfunction	Stem Cell Exhaustion	Renal function, CKD cause, CVD history and endothelial dysfunction parameters were determined as factors of influence on progenitor cells.	20083473
Malignant neoplasm of urinary bladder	Stem Cell Exhaustion	Recently, two genome-wide association studies identified a significant association between the prostate stem cell antigen (PSCA) rs2294008 (C>T) polymorphism and risk of diffuse-type of gastric cancer in Asians and bladder cancer in Caucasians, respectively.	20083643
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	Clinical significance of prostate stem cell antigen expression in non-small cell lung cancer.	20085909
Prostate carcinoma	Stem Cell Exhaustion	Prostate stem cell antigen was originally identified as an overexpressed gene in prostate cancer and its overexpression correlated with disease progression and prognosis.	20085909
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	In this study, we investigated the clinical significance and therapeutic potential of prostate stem cell antigen expression in non-small cell lung cancer.	20085909
Non-Small Cell Lung Carcinoma, Primary Neoplasm	Stem Cell Exhaustion	Prostate stem cell antigen expression was examined by immunohistochemistry in 97 primary tumors and 21 metastatic lymph nodes from non-small cell lung cancer patients who underwent curative resection from January 2001 through March 2003.	20085909
Malignant neoplasm of lung	Stem Cell Exhaustion	Therapeutic potential of targeting prostate stem cell antigen was further examined by small interfering RNA method using human lung cancer cell line (A549).	20085909
PSCA gene, prostate stem cell antigen	Stem Cell Exhaustion	The prognosis of patients with low prostate stem cell antigen expression was significantly better than those with high prostate stem cell antigen expression (5-year disease-free survival rate; 90% vs. 53%, P = 0.001).	20085909
Malignant neoplasm of lung	Stem Cell Exhaustion	Finally, small interfering RNA-mediated knockdown of prostate stem cell antigen resulted in the inhibition of lung cancer cell growth.	20085909
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	Prostate stem cell antigen is highly expressed in non-small cell lung cancer and may be functionally important for this fatal disease.	20085909
Recurrent ovarian cancer, Acute lymphocytic leukemia	Stem Cell Exhaustion	Breast and ovarian recurrence of acute lymphoblastic leukaemia after allogeneic peripheral blood haematopoietic stem cell transplantation.	20087541
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	Breast recurrence of acute lymphoblastic leukaemia (ALL) after stem cell transplant is uncommon, with less than 20 reported cases in the literature.	20087541
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Successful treatment of acute myelogenous leukemia with favorable cytogenetics by reduced-intensity stem cell transplantation.	20087795
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Since the efficacy of reduced-intensity stem cell transplantation (RIST) for AML with favorable cytogenetics has not been established, we retrospectively analyzed the outcomes of allo-HSCT in AML patients according to cytogenetic risks.	20087795
Primary amyloidosis	Stem Cell Exhaustion	High-dose melphalan with autologous peripheral blood stem cell transplantation (ASCT) is an effective treatment for systemic primary amyloidosis.	20088306
Multiple Myeloma	Stem Cell Exhaustion	Stem cell transplantation in multiple myeloma: impact of response failure with thalidomide or lenalidomide induction.	20089967
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation as a platform for multiple myeloma treatment is the standard of care for patients who can safely withstand the procedure.	20089967
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	Unusual sites of relapses following allogenic hematopoietic stem cell transplantation (HSCT) for acute lymphoblastic leukemia (ALL) are rarely reported.	20090251
Antilymphocyte Serum	Stem Cell Exhaustion	Since MMPs act as fundamental effectors of extra-cellular matrix remodeling and stem cell mobilization, their modifications in ALS may influence reparative mechanisms effective in counteracting the pathology.	20091292
Matrix Metalloproteinase 9	Stem Cell Exhaustion	Moreover, by quantitative real-time approach, we observed altered Collagen IV and Metalloproteinase-9 levels in patients' derived mesenchymal stem cells (MSCs).	20091292
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Although high-dose sequential chemotherapy followed by autologous hematopoietic stem cell transplantation has been reported to improve overall survival in patients with PTCL, this therapy is only feasible for the small minority of patients who experience a durable complete response to induction therapy.	20095101
Mycoses, Acute leukemia	Stem Cell Exhaustion	Epidemiology of paediatric invasive fungal infections and a case-control study of risk factors in acute leukaemia or post stem cell transplant.	20096013
Acute leukemia	Stem Cell Exhaustion	Cases with an underlying diagnosis of acute leukaemia or following stem cell transplantation were included in a case control study.	20096013
Acute leukemia	Stem Cell Exhaustion	Controls included all other children with acute leukaemia or stem cell transplant in the corresponding time period.	20096013
Mycoses, Leukemia, Myelocytic, Acute, Acute lymphocytic leukemia	Stem Cell Exhaustion	The incidence of invasive fungal infection was 21% in acute lymphoblastic leukaemia, 15% in acute myeloid leukaemia and 25% following stem cell transplantation.	20096013
Pfaundler-Hurler Syndrome	Stem Cell Exhaustion	Dried blood spot analysis: an easy and reliable tool to monitor the biochemical effect of hematopoietic stem cell transplantation in hurler syndrome patients.	20096360
Multiple Myeloma, Chromosome Aberrations	Stem Cell Exhaustion	Negative prognostic significance of two or more cytogenetic abnormalities in multiple myeloma patients treated with autologous stem cell transplantation.	20099973
myocardial injury	Stem Cell Exhaustion	Juvenile exposure to anthracyclines impairs cardiac progenitor cell function and vascularization resulting in greater susceptibility to stress-induced myocardial injury in adult mice.	20100968
Electrocardiogram: myocardial infarction (finding), Infarction	Stem Cell Exhaustion	Progenitor cells participate in regeneration and blood vessel formation after a myocardial infarction, but doxorubicin-treated mice had fewer progenitor cells in the infarct border zone.	20100968
Hepatitis B	Stem Cell Exhaustion	Sustained seroconversion of chronic hepatitis B infection after stem cell transplantation.	20102530
Cerebrovascular accident	Stem Cell Exhaustion	In the groups undergoing pulmonary artery banding, cord blood stem cell transplantation was accompanied by functional benefits compared with placebo injection: end-systolic elastance increased by a mean of 1.4 +/- 0.2 mm Hg/mL compared with 0.9 +/- 0.1 mm Hg/mL, and the slope of preload recruitable stroke work increased by 21.1 +/- 2.9 mm Hg compared with 15.8 +/- 2.5 mm Hg.	20103347
Cerebrovascular accident	Stem Cell Exhaustion	Induction of nestin- and musashi-1-positive cells, potential neural stem/progenitor cells, was observed at the site of ischemic lesions from day 1 after stroke.	20104652
Malignant Neoplasms	Stem Cell Exhaustion	In a Cox multivariate analysis risk factors for a Grade 3 or 4 condition included minority race, diagnosis of other malignancy, older age, and a history of a hematopoietic stem cell transplant.	20108334
Neutropenia, Graft-vs-Host Disease	Stem Cell Exhaustion	In our study these risk factors included neutropenia (n = 34, 52%), stem cell transplantation (SCT; n = 30, 45%), graft versus host disease (GVHD; n = 22, 33%), and steroid use (n = 29, 44%).	20109093
Cessation of life, Graft-vs-Host Disease	Stem Cell Exhaustion	Cotransplantation of mesenchymal stem cells might prevent death from graft-versus-host disease (GVHD) without abrogating graft-versus-tumor effects after HLA-mismatched allogeneic transplantation following nonmyeloablative conditioning.	20109568
Graft-vs-Host Disease	Stem Cell Exhaustion	Recent studies have suggested that coinfusion of mesenchymal stem cells (MSCs) the day of hematopoietic cell transplantation (HCT) might promote engraftment and prevent graft-versus-host disease (GVHD) after myeloablative allogeneic HCT.	20109568
Hematologic Neoplasms	Stem Cell Exhaustion	Twenty patients with hematologic malignancies were given MSCs from third party unrelated donors 30-120 minutes before peripheral blood stem cells (PBSCs) from HLA-mismatched unrelated donors, after conditioning with 2 Gy total body irradiation (TBI) and fludarabine.	20109568
Dementia, "Alzheimers Disease	Stem Cell Exhaustion	Increased circulating progenitor cells in Alzheimer's disease patients with moderate to severe dementia: evidence for vascular repair and tissue regeneration?	20110604
Up	Stem Cell Exhaustion	Whether CD34+ and, specifically, CD34+/CD133+ progenitor cells are involved in the pathophysiology of AD is poorly understood so far.	20110604
Up	Stem Cell Exhaustion	In the present study, peripheral blood concentrations of circulating CD34+/CD133+ and CD34+ progenitor cells were measured in 45 AD patients and in 30 healthy elderly controls by flow cytometry.	20110604
Up, Dementia	Stem Cell Exhaustion	In the present study, AD patients with moderate to severe dementia, but not those with mild dementia, showed significantly increased circulating CD34+/CD133+ and CD34+ progenitor cells compared to healthy elderly controls independent of cardiovascular risk factors and medication.	20110604
Up	Stem Cell Exhaustion	In addition, the number of circulating CD34+/CD133+ progenitor cells in AD patients was significantly inversely correlated with cognitive function, age, and plasma levels of SDF-1, the most potent chemokine for progenitor cells.	20110604
Up	Stem Cell Exhaustion	Our findings suggest a stage-dependent upregulation of circulating CD34+/CD133+ and CD34+ progenitor cells in AD patients, which could take part in tissue healing processes of the brain in AD.	20110604
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Graft-versus-lymphoma effect after reduced intensity allogeneic hematopoietic stem cell transplantation from HLA-two loci mismatched father in a patient with refractory non-Hodgkin lymphoma.	20112609
Hematological Disease	Stem Cell Exhaustion	Immunohematopoietic stem cell transplantation has curative potential in selected hematologic disorders.	20118055
Lung Diseases, Fungal	Stem Cell Exhaustion	Risk factors for fungal pulmonary infections in hematopoietic stem cell transplantation recipients: the role of iron overload.	20118991
Lung Diseases, Fungal	Stem Cell Exhaustion	Fungal pulmonary infections (FPIs) are frequent causes of mortality in hematopoietic stem cell transplantation (HSCT) recipients.	20118991
Hematologic Neoplasms, Palmar-plantar erythrodysesthesia syndrome	Stem Cell Exhaustion	Chemotherapy-induced mesenchymal stem cell damage in patients with hematological malignancy.	20119670
Hematopoietic stem cells	Stem Cell Exhaustion	This is generally attributed to progressive hematopoietic stem cell failure, although defective hematopoiesis may be in part due to poor stromal function.	20119670
Multiple Myeloma	Stem Cell Exhaustion	With evolving concepts concerning the presence of myeloma stem (initiating) cells, we aimed this investigation to specifically address the supportive role of BMSCs for myeloma stem cell growth in vitro and in vivo.	20121456
Multiple Myeloma	Stem Cell Exhaustion	Bone marrow stromal cells from myeloma patients support the growth of myeloma stem cells.	20121456
Multiple Myeloma	Stem Cell Exhaustion	Myeloma stem cells of the RPMI 8226 myeloma cell line were recognized through the identification of "side populations" (SP) with Hoechst dye staining.	20121456
Multiple Myeloma	Stem Cell Exhaustion	These findings indicate that the myeloma BMSCs create a microenvironment supportive of myeloma stem cells via, at least partially, the CXCR4 signaling pathway.	20121456
Bone Diseases	Stem Cell Exhaustion	This review summarizes the recent findings of proteomic studies on bone diseases, properties of mesenchymal stem cells with high expansion rates and osteoblast and osteoclast differentiation, with emphasis on the role of quantitative proteomics in the study of signaling dynamics, biomarkers and discovery of therapeutic targets.	20121480
Hemorrhage	Stem Cell Exhaustion	Post hematopoietic stem cell transplantation (HSCT) gastrointestinal (GI) bleeding is a dreaded complication.	20121552
Gastrointestinal Hemorrhage	Stem Cell Exhaustion	We present a 10 month-old female child, who had three episodes of life threatening lower GI bleeding post unrelated Umbilical Stem Cell Transplant (UCBT) controlled successfully each time by use of rFVIIa and octreotide infusion and review of literature.	20121552
Cytomegalovirus Reactivation	Stem Cell Exhaustion	Epstein-Barr virus (EBV) and cytomegalovirus reactivations are frequent complications of hematopoeitic allogeneic stem cell transplantation (SCT) because of a lack of T cell control after immunosuppression.	20121571
Lymphoma	Stem Cell Exhaustion	Prognostic role of PET scanning before and after reduced-intensity allogeneic stem cell transplantation for lymphoma.	20124510
Lymphoma	Stem Cell Exhaustion	Allogeneic stem cell transplantation (SCT) is an established therapy for patients with relapsed lymphoma, but the role of positron emission tomography (PET) scanning preallogeneic and postallogeneic SCT is uncertain.	20124510
Graft-vs-Host Disease	Stem Cell Exhaustion	Because of its potent immunosuppressive yet stem cell-sparing activity, high-dose cyclophosphamide was tested as sole prophylaxis of graft-versus-host disease (GVHD) after myeloablative allogeneic bone marrow transplantation (alloBMT).	20124511
Parkinson Disease	Stem Cell Exhaustion	Open-labeled study of unilateral autologous bone-marrow-derived mesenchymal stem cell transplantation in Parkinson's disease.	20129486
Neurodegenerative Disorders, palladium, Parkinson Disease	Stem Cell Exhaustion	Parkinson's disease (PD) is a progressive neurodegenerative disease for which stem cell research has created hope in the last few years.	20129486
palladium	Stem Cell Exhaustion	These results indicate that our protocol seems to be safe, and no serious adverse events occurred after stem-cell transplantation in PD patients.	20129486
palladium	Stem Cell Exhaustion	Seven PD patients aged 22 to 62 years with a mean duration of disease 14.7+/-7.56 years were enrolled to participate in the prospective, uncontrolled, pilot study of single-dose, unilateral transplantation of autologous bone-marrow-derived mesenchymal stem cells (BM-MSCs).	20129486
Restenosis, Coronary Arteriosclerosis	Stem Cell Exhaustion	Role of endothelial progenitor cells in restenosis and progression of coronary atherosclerosis after percutaneous coronary intervention: a prospective study.	20129574
Coronary Arteriosclerosis, In-Stent Restenosis Indicator	Stem Cell Exhaustion	We prospectively investigated the relationship of circulating endothelial progenitor cells at time of percutaneous coronary intervention to the subsequent development of in-stent restenosis or progression of coronary atherosclerosis.	20129574
Atherosclerosis	Stem Cell Exhaustion	Endothelial progenitor cells provide an endogenous repair mechanism of the dysfunctional endothelium and therefore can play a pathogenic role in coronary atherosclerosis.	20129574
Restenosis, Coronary Arteriosclerosis	Stem Cell Exhaustion	Patients with restenosis have higher numbers of subpopulations of endothelial progenitor cells that incorporate into endothelial cells or play a role in arteriogenesis compared with controls and patients with either progression of coronary atherosclerosis or stable disease.	20129574
Degenerative polyarthritis	Stem Cell Exhaustion	Sex differences of chondrogenic progenitor cells in late stages of osteoarthritis.	20131243
Degenerative polyarthritis	Stem Cell Exhaustion	We undertook this study to determine whether the regenerative potential of chondrogenic progenitor cells (CPCs) present in the arthritic tissue during the late stages of human OA might also be subject to sex-specific differences and influenced by sex steroids.	20131243
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Predictive value of (18)F-FDG hybrid PET/CT for the clinical outcome in patients with non-Hodgkin's lymphoma prior to and after autologous stem cell transplantation.	20132658
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Evaluation of therapeutic response in non-Hodgkin's lymphoma (NHL) patients with autologous stem cell transplantation (ASCT) is of great clinical significance.	20132658
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	(18)F-FDG hybrid PET/CT imaging prior to and following autologous stem cell transplantation in NHL contains predictive information on the long-term clinical outcome.	20132658
Neoplasms	Stem Cell Exhaustion	Stem cell marker nestin has been reported to be activated in various neoplasms, and its expression is correlated with poor prognosis.	20132963
Cessation of life, Complication Aspects, Mycoses	Stem Cell Exhaustion	Systemic fungal infection (SFI) is now one of the main causes of death from infective complications after hematopoietic stem cell transplantation (HSCT) and the role of prophylaxis of fungal infection has been established.	20134142
Hepatic Veno-Occlusive Disease	Stem Cell Exhaustion	[Usefulness of serum plasminogen activator inhibitor-1 for diagnosis and monitoring of late-onset sinusoidal obstruction syndrome after allogeneic stem cell transplantation].	20134143
Glioblastoma	Stem Cell Exhaustion	Association of stem cell marker CD133 expression with dissemination of glioblastomas.	20135187
Adult Glioblastoma	Stem Cell Exhaustion	We tested in this study for an association between the expression of stem cell marker CD133 and the risk of dissemination in 26 cases of glioblastoma (16 with dissemination and 10 without dissemination).	20135187
Adult Glioblastoma, Specialty Type - cancer	Stem Cell Exhaustion	The results suggest that CD133 could be a molecular predictor of glioblastoma dissemination, and also give rise to an intriguing idea that CD133-positive cancer stem cells may be implicated in the initiation of disseminated lesions.	20135187
Specialty Type - cancer	Stem Cell Exhaustion	Of the 57 cases, cancer stem cells were detected in 52, including OCT4(+) bronchioloalveolar stem cell (BASC) phenotype (SP-C(+) CCSP(+) OCT4(+)) in 40 cases and OCT4(-) BASC phenotype (SP-C(+) CCSP(+) OCT4(-)) in 12 cases.	20137348
Adenocarcinoma of lung (disorder), Specialty Type - cancer	Stem Cell Exhaustion	To detect the cancer stem cells and to evaluate their prognostic implication in patients with lung adenocarcinoma.	20137348
Adenocarcinoma of lung (disorder), Specialty Type - cancer	Stem Cell Exhaustion	Three phenotypic markers of cancer stem cells (SP-C, CCSP and OCT4) in lung adenocarcinoma were detected by immunofluorecence staining.	20137348
Specialty Type - cancer	Stem Cell Exhaustion	The correlation among the clinicopathological parameters and phenotypes of cancer stem cells as well as survival were analyzed by Cox proportional hazard method.	20137348
Specialty Type - cancer	Stem Cell Exhaustion	Statistical analysis revealed that the phenotype of cancer stem cells was related with the cellular differentiation, i.e.	20137348
Adenocarcinoma of lung (disorder)	Stem Cell Exhaustion	The lung adenocarcinoma stem cells have phenotypic features of bronchioalveolar stem cells (SP-C(+) CCSP(+)).	20137348
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Total body irradiation compared with BEAM: Long-term outcomes of peripheral blood autologous stem cell transplantation for non-Hodgkin's lymphoma.	20137862
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	The optimal preparative regimen for non-Hodgkin's lymphoma patients undergoing autologous peripheral blood stem cell transplantation (PBSCT) is unknown.	20137862
Hematologic Neoplasms	Stem Cell Exhaustion	Most (71%) patients had uncontrolled hematological malignancy and 21 patients (47%) received hematopoietic stem cell transplantation (85% allogeneic).	20138081
Influenza due to Influenza A virus subtype H1N1, Specialty Type - cancer	Stem Cell Exhaustion	2009 H1N1 influenza infection in cancer patients and hematopoietic stem cell transplant recipients.	20138188
Specialty Type - cancer	Stem Cell Exhaustion	To determine outcome in patients with cancer and/or hematopoietic stem cell transplant (HSCT), we reviewed our recent experience at Memorial Sloan-Kettering Cancer Center (MSKCC).	20138188
Dementia, Vascular, Infarction	Stem Cell Exhaustion	The results were striking, showing a significant increase of progenitor cells in both the subventricular zone and in peri-infarct area in patients with vascular dementia compared to controls, which was sustained even in patients with infarcts occurring more than three months prior to autopsy.	20138403
Extramedullary	Stem Cell Exhaustion	Gemtuzumab ozogamicin therapy for isolated extramedullary AML relapse after allogeneic hematopoietic stem-cell transplantation.	20139663
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Imatinib induces sustained remissions in patients with chronic myelogenous leukemia (CML), but fails to eradicate CML stem cells.	20142590
CHROMOSOME 8p11 MYELOPROLIFERATIVE SYNDROME, Myeloproliferative disease, Eosinophil count raised (finding)	Stem Cell Exhaustion	Three of the four FGFR1-rearranged cases were associated with myeloproliferative neoplasms but none, including the two with sole 8p11.2, displayed the typical phenotype for stem cell leukemia/lymphoma (SCLL) and only one had eosinophilia; the fourth case had AML-M4.	20143402
Acute lymphocytic leukemia	Stem Cell Exhaustion	Adults with high-risk acute lymphoblastic leukemia (HR-ALL) have a poor outcome with standard chemotherapy and usually undergo unrelated stem cell transplantation (SCT) if a matched sibling donor is not available.	20144909
Disease	Stem Cell Exhaustion	Although Argonaute proteins are considered to play important roles in stem cell self-renewal, RNA interference (RNAi) and translational regulation, relatively little is known about their functions in human disease.	20146808
Specialty Type - cancer, Cholangiocarcinoma	Stem Cell Exhaustion	We aimed to demonstrate that alpha-fetoprotein (AFP)-producing cells in cholangiocarcinomas possessed cancer stem cell (CSC)-like properties.	20149523
Specialty Type - cancer, Cholangiocarcinoma	Stem Cell Exhaustion	Alpha-fetoprotein producing cells act as cancer progenitor cells in human cholangiocarcinoma.	20149523
Heart failure	Stem Cell Exhaustion	Direct myocardial implantation of human fetal stem cells in heart failure patients: long-term results.	20150037
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Time course and mechanisms of circulating progenitor cell reduction in the natural history of type 2 diabetes.	20150295
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	The present study was designed to describe the extent and potential mechanisms of progenitor cell reduction during the natural history of type 2 diabetes.	20150295
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Circulating progenitor cell reduction marks the clinical onset of type 2 diabetes.	20150295
Cardiovascular Diseases, Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Reduction of bone marrow-derived circulating progenitor cells has been proposed as a novel mechanism of cardiovascular disease in type 2 diabetes.	20150295
Thrombotic Microangiopathies, Chronic Kidney Disease, CTCAE, Hypertension, CTCAE	Stem Cell Exhaustion	Chronic kidney disease, thrombotic microangiopathy, and hypertension following T cell-depleted hematopoietic stem cell transplantation.	20153836
Chronic Kidney Diseases, Chronic Kidney Disease, CTCAE	Stem Cell Exhaustion	Chronic kidney disease (CKD) is now an accepted long-term complication of allogeneic hematopoietic stem cell transplantation.	20153836
Primary Myelofibrosis, PMF Regimen	Stem Cell Exhaustion	Fifty-one patients with primary myelofibrosis (PMF) received allogeneic haematopoietic stem cell transplants from related (n=33) or unrelated (n=18) donors.	20154739
Multiple Myeloma	Stem Cell Exhaustion	Abnormal protein bands in patients with multiple myeloma after haematopoietic stem cell transplantation: does it have a prognostic significance?	20155734
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Abnormal protein bands (APB) unrelated to the original monoclonal protein occasionally appear in serum immunofixation samples from patients with multiple myeloma (MM) following haematopoietic stem cell transplantation (HCT).	20155734
melanoma	Stem Cell Exhaustion	Prognostic significance of the hair follicle stem cell marker nestin in patients with malignant melanoma.	20156773
Neoplasms	Stem Cell Exhaustion	Aging is generally considered to be the consequence of stem cell attrition caused by the activity of tumor suppressor pathways that censor potentially malignant clones by eliciting apoptosis or senescence.	20157576
Posterior reversible encephalopathy syndrome, Acute lymphocytic leukemia	Stem Cell Exhaustion	We describe rapidly progressive PRES following stem cell transplant for acute lymphoblastic leukemia.	20158377
Diabetes, Chronic disease, Spinal Cord Injuries, Ischemia, Parkinson Disease, "Alzheimers Disease	Stem Cell Exhaustion	The use of mesenchymal stem cells (MSCs) has been shown to be promising in chronic disorders such as diabetes, Alzheimer's dementia, Parkinson's disease, spinal cord injury and brain ischemia.	20158462
Tooth Germ	Stem Cell Exhaustion	In this report, we isolated human tooth germ stem cells (hTGSCs) with MSC characteristics from third molar tooth germs, cryo-preserved them at -80( degrees )C for 6 months, and evaluated for their surface antigens, expression of pluri-potency associated genes, differentiation capacity, karyotype, and proliferation rate.	20158462
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	In multiple myeloma (MM), allogeneic stem cell transplantation (alloHCT) carries a lower relapse risk than autologous transplantation but a greater transplant-related mortality.	20162541
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	An allogenic hematopoietic stem cell transplantation or new molecular target therapy might be finally selected for refractory peripheral T cell lymphoma.	20163018
Malignant melanoma of conjunctiva	Stem Cell Exhaustion	Persistent epitheliopathy, presumably resulting from limbal stem cell deficiency, is an uncommon complication of treatment of conjunctival malignant melanoma with surgical excision, cryotherapy, and mitomycin C. The Boston Ocular Surface Prosthesis was successful in improving vision, comfort, and epithelial status in our patients.	20164756
Epidermolysis Bullosa	Stem Cell Exhaustion	Ocular surface reconstruction with cultivated limbal epithelium in a patient with unilateral stem cell deficiency caused by Epidermolysis bullosa dystrophica hallopeau-Siemens.	20164760
Epidermolysis Bullosa Dystrophica	Stem Cell Exhaustion	To report a case of partial limbal stem cell deficiency (LSCD) caused by epidermolysis bullosa dystrophica mutilans Hallopeau-Siemens treated by transplantation of autologous ex vivo expanded limbal epithelium.	20164760
Medulloblastoma	Stem Cell Exhaustion	High-dose carboplatin, thiotepa, and etoposide with autologous stem cell rescue for patients with previously irradiated recurrent medulloblastoma.	20167818
Infant Acute Lymphoblastic Leukemia	Stem Cell Exhaustion	Graft-versus-leukemia effect on infant lymphoblastic leukemia relapsed after sibling hematopoietic stem cell transplantation.	20168246
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	Stem Cell Exhaustion	An earlier healthy 9-week-old Hispanic male diagnosed with precursor B-cell lymphoblastic leukemia was treated with protocol P9407 and matched sibling hematopoietic stem cell transplantation.	20168246
BCR gene	Stem Cell Exhaustion	Traditionally, graft-versus-leukemia effect was thought to contribute therapeutically little to the treatment of ALL by hematopoietic stem cell transplantation (HSCT).	20168246
Metabolic Syndrome X, Renal Insufficiency	Stem Cell Exhaustion	Decreased number and impaired functionality of endothelial progenitor cells in subjects with metabolic syndrome: implications for increased cardiovascular risk.	20171637
Cardiovascular Diseases, Cyclophosphamide/Vincristine/Dacarbazine Regimen	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) are a measure of vascular health and are decreased in patients with various risk factors for cardiovascular disease (CVD).	20171637
Neutropenia, infectious - Entity Risk, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Clinical impact and predisposing factors of delayed-onset neutropenia after autologous hematopoietic stem-cell transplantation for B-cell non-Hodgkin lymphoma: association with an incremental risk of infectious events.	20172906
Neutropenia	Stem Cell Exhaustion	Clinical significance of delayed-onset neutropenia (DON) after autologous hematopoietic stem-cell transplantation (ASCT) has not been well described.	20172906
THROMBOCYTOPENIA 1 (disorder)	Stem Cell Exhaustion	Whereas stem cell transplantation at an early age is the treatment of choice for patients with WAS, therapeutic options for patients with XLT are controversial.	20173115
Hepatic Veno-Occlusive Disease	Stem Cell Exhaustion	Plasma brain natriuretic peptide is associated with hepatic veno-occlusive disease and early mortality after allogeneic hematopoietic stem cell transplantation.	20173786
Venoocclusive disease	Stem Cell Exhaustion	We hypothesized that plasma brain natriuretic peptide (BNP), a neurohormone secreted in response to volume expansion, may be associated with VOD after hematopoietic stem cell transplantation (HSCT).	20173786
Peripheral Nervous System Diseases	Stem Cell Exhaustion	Enriched population of PNS neurons derived from human embryonic stem cells as a platform for studying peripheral neuropathies.	20174633
Colorectal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Establishment and characterization of 13 human colorectal carcinoma cell lines: mutations of genes and expressions of drug-sensitivity genes and cancer stem cell markers.	20176655
Specialty Type - cancer	Stem Cell Exhaustion	The cancer stem cell biomarkers CD133, CD44 and Lgr5 were expressed in 12, 13 and 13 cell lines, respectively.	20176655
Specialty Type - cancer, Cytogenetic Complete Response	Stem Cell Exhaustion	The presently well-characterized CRC cell lines should be useful in investigations of the biological characteristics of CRC, particularly for investigations related to gene alterations associated with CRC and biology of cancer stem cells.	20176655
Ischemia	Stem Cell Exhaustion	Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice.	20176987
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells are believed to be the driving force behind tumor progression and development.	20178779
Specialty Type - cancer	Stem Cell Exhaustion	Despite extensive studies on the effects of cryopreservation on embryonic and hematopoietic stem cells there is only limited data that directly deals with in the cryopreservation of cancer stem cells.	20178779
Childhood Breast Carcinoma	Stem Cell Exhaustion	The stability of breast cancer progenitor cells during cryopreservation: Maintenance of proliferation, self-renewal, and senescence characteristics.	20178779
Breast Carcinoma, Childhood Breast Carcinoma	Stem Cell Exhaustion	In this study, we looked at the effect of cryopreservation on breast cancer progenitor cells known as mammospheres, which are derived from the MCF7 breast carcinoma cell line.	20178779
Multiple Myeloma	Stem Cell Exhaustion	Reduced-intensity allogeneic hematopoietic stem cell transplantation for relapsed multiple myeloma.	20178853
Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	These data provide a useful resource for future studies, including those of potential tumor progenitor cells, which may help illuminate the etiology and natural history of these cancers.	20179752
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Reduced intensity conditioning prior to allogeneic stem cell transplantation in first complete remission is effective in patients with acute myeloid leukemia and an intermediate-risk karyotype.	20180052
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	To evaluate the efficacy of reduced intensity conditioning (RIC) prior to allogeneic stem cell transplantation (alloSCT) in patients with acute myeloid leukemia (AML) in first complete remission (CR1), we retrospectively analyzed the outcome of 93 consecutive patients transplanted at our institution either following RIC (n = 37) or standard myeloablative conditioning (MAC) (n = 56) between 1999 and 2007.	20180052
Neoplasms	Stem Cell Exhaustion	The novel stem cell marker SALL4 has been identified as a diagnostic marker of germ cell tumors, especially yolk sac tumors, in gonadal organs.	20182341
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We conducted a retrospective study on 138 patients aged less than 60 years diagnosed with core binding factor acute myeloid leukaemia between 1994 and 2006, comparing allogeneic stem cell transplantation and high-dose cytarabine chemotherapy as post-remission treatment options after the first remission.	20185460
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Especially, 3-year probabilities of disease-free survival (95.2% vs. 59.3%, P = 0.008) and overall survival (95.2% vs. 59.6%, P = 0.032) of allogeneic stem cell transplantation group were significantly better than high-dose cytarabine group in cohort after 2003 of acute myeloid leukaemia patients with t(8;21).	20185460
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic stem cell transplantation is currently the more effective post-remission therapy than it was prior to 2003 for core binding factor acute myeloid leukaemia achieving first remission.	20185460
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	On the contrary to previous findings, allogeneic stem cell transplantation provides significantly improved outcomes than high-dose cytarabine chemotherapy in acute myeloid leukaemia with t(8;21).	20185460
Pulmonary Dysfunction	Stem Cell Exhaustion	Pulmonary dysfunction in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem cell transplantation.	20186702
Immunodeficiency with thymoma	Stem Cell Exhaustion	Pure red cell aplasia associated with Good's syndrome accompanied by decreased stem cell factor production in the bone marrow.	20190468
Congestive heart failure	Stem Cell Exhaustion	A 55-year-old woman was diagnosed with POEMS syndrome; however, we could not perform high-dose chemotherapy with autologous peripheral blood stem cell transplantation (auto-PBSCT) because of rapidly progressive congestive heart failure.	20190484
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Two hundred and sixty-six patients with newly diagnosed multiple myeloma (MM) were primarily treated with thal-dex in preparation for subsequent high-dose therapy and autologous stem-cell transplantation.	20192986
Colorectal Carcinoma	Stem Cell Exhaustion	Effects of heterochromatin in colorectal cancer stem cells on radiosensitivity.	20193109
Specialty Type - cancer	Stem Cell Exhaustion	The radioresistance of cancer stem cells (CSCs) is a key factor that influences therapeutic effectiveness.	20193109
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Targeting integrin linked kinase and FMS-like tyrosine kinase-3 is cytotoxic to acute myeloid leukemia stem cells but spares normal progenitors.	20193963
Toxic effect	Stem Cell Exhaustion	In contrast, little toxicity toward normal bone marrow progenitors was observed, demonstrating that candidate leukemic stem cells can be eliminated by inhibition of these targets while normal hematopoietic counterparts are spared.	20193963
Kidney Failure, Multiple Myeloma	Stem Cell Exhaustion	Thalidomide-dexamethasone as induction therapy before autologous stem cell transplantation in patients with newly diagnosed multiple myeloma and renal insufficiency.	20197100
Kidney Failure, Toxic effect, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The aim of this study was to evaluate the efficacy and the toxicity of thalidomide-dexamethasone (Thal-Dex) as induction therapy before autologous peripheral blood stem cell (PBSC) transplantation in patients with newly diagnosed multiple myeloma (MM) with renal insufficiency.	20197100
T-Cell Lymphoma	Stem Cell Exhaustion	Evaluation of enteropathy-associated T-cell lymphoma comparing standard therapies with a novel regimen including autologous stem cell transplantation.	20197551
TRPV6 wt Allele	Stem Cell Exhaustion	We describe EATL in a population-based setting and evaluate a new treatment with aggressive chemotherapy and autologous stem cell transplantation (ASCT).	20197551
Malignant Neoplasms	Stem Cell Exhaustion	Mutations in bone marrow-derived stromal stem cells unmask latent malignancy.	20199238
Breast Carcinoma	Stem Cell Exhaustion	To address this question, Apc(Min/+) and Apc(Min/+) Rag2(-/-) mice, which have a predilection to mammary carcinoma (as well as wild-type (wt) mice), received mesenchymal stem cells (MSC) with mutant p53 (p53MSC) transferred via tail vein injection.	20199238
Neutropenia, Hematologic Neoplasms, Pulmonary Aspergillosis	Stem Cell Exhaustion	Invasive pulmonary aspergillosis (IPA) is a major cause of morbidity and mortality in patients with hematological malignancies in the setting of profound neutropenia and/or hematopoietic stem cell transplantation.	20199673
Childhood Burkitt Lymphoma	Stem Cell Exhaustion	Successful mobilization with AMD3100 and filgrastim with engraftment of autologous peripheral blood stem cells in a heavily pretreated pediatric patient with recurrent Burkitt lymphoma.	20201695
Neoplasms	Stem Cell Exhaustion	Hematopoietic progenitor cells were subsequently successfully mobilized with a combination of AMD3100 and filgrastim without tumor or fungus contamination.	20201695
Childhood Burkitt Lymphoma	Stem Cell Exhaustion	This is the first case report of a pediatric patient with relapsed Burkitt lymphoma with mobilization of hematopoietic progenitor cells by AMD3100 without any adverse reactions.	20201695
Glioblastoma Multiforme Pathway, Malignant Glioma	Stem Cell Exhaustion	Recent evidence suggests that a glioma stem cell subpopulation might contribute to radioresistance in malignant gliomas.	20205512
Nasopharyngeal carcinoma	Stem Cell Exhaustion	Notch1 signaling is activated in cells expressing embryonic stem cell proteins in human primary nasopharyngeal carcinoma.	20211102
Acute myocardial infarction	Stem Cell Exhaustion	Results of intracoronary stem cell therapy after acute myocardial infarction.	20211323
Coronary Arteriosclerosis	Stem Cell Exhaustion	In patients with coronary artery disease (CAD), higher numbers of circulating endothelial progenitor cells (EPC) favourably influence clinical outcome.	20211468
Hematologic Neoplasms	Stem Cell Exhaustion	All patients admitted with hematological malignancy and undergoing chemotherapy or stem cell transplant were included.	20214445
Malignant neoplasm of liver	Stem Cell Exhaustion	Liver surgery induces an immediate mobilization of progenitor cells in liver cancer patients: A potential role for G-CSF.	20215863
Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	In preclinical models recruitment of bone-marrow derived (endothelial) progenitor cells (BD(E)PCs) contributes to tumor growth and metastasis formation.	20215863
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Efficacy of rituximab and cladribine in patients with chronic lymphocytic leukemia and feasibility of stem cell mobilization: a prospective multicenter phase II trial (protocol SAKK 34/02).	20218808
Opportunistic Infections, Toxoplasmosis	Stem Cell Exhaustion	Toxoplasmosis is an often fatal opportunistic infection following allogeneic hematopoietic stem cell transplantation and is largely due to deferred diagnosis.	20218875
Mycoses	Stem Cell Exhaustion	Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001-2006: overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database.	20218877
Cessation of life, Intraoperative floppy iris syndrome, Mycoses	Stem Cell Exhaustion	The incidence and epidemiology of invasive fungal infections (IFIs), a leading cause of death among hematopoeitic stem cell transplant (HSCT) recipients, are derived mainly from single-institution retrospective studies.	20218877
Specialty Type - cancer	Stem Cell Exhaustion	Age is the most important demographic risk factor for cancer, and we hypothesized that its carcinogenic potential may be referred by irreversibly stabilizing stem cell features.	20219944
S100A4 protein, human	Stem Cell Exhaustion	These findings shed substantial novel insights into the epigenetic effects of aging and support the view that age may predispose to malignant transformation by irreversibly stabilizing stem cell features.	20219944
Specialty Type - cancer	Stem Cell Exhaustion	Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer.	20219944
Mantle cell lymphoma	Stem Cell Exhaustion	Background There is currently no international consensus for first-line treatment (prior to autologous stem cell transplantation) in mantle cell lymphoma patients.	20220059
Hemorrhagic cystitis	Stem Cell Exhaustion	BK virus-associated hemorrhagic cystitis presenting as mural nodules in the urinary bladder after hematopoietic stem cell transplantation.	20221593
Hemorrhagic cystitis, Virus Diseases, Acute lymphocytic leukemia	Stem Cell Exhaustion	We report an unusual sonographic presentation of late-onset hemorrhagic cystitis caused by BK virus infection in an 8-year-old who had undergone hematopoietic stem cell transplantation for treatment of relapsed acute lymphoblastic leukemia.	20221593
Toxic effect	Stem Cell Exhaustion	CTD resulted in a favorable response with tolerable toxicity in patients with MM and did not affect the yield of the stem cell collection.	20223731
Cessation of life, Neurologic decline, Lupus Erythematosus, Unspecified visual loss	Stem Cell Exhaustion	A 23-year-old man (Case 1) with systemic lupus erythematosus developed rapid and severe vision loss, generalized neurologic decline, and eventual death after administration of fludarabine before stem cell transplantation.	20224467
Degenerative polyarthritis	Stem Cell Exhaustion	Novel insights into the mechanism of decreased expression of type X collagen in human mesenchymal stem cells from patients with osteoarthritis cultured on nitrogen-rich plasma polymers: implication of cyclooxygenase-1.	20225218
Hypertrophy, Degenerative polyarthritis, Endochondral Ossification	Stem Cell Exhaustion	Recent evidence indicates that a major drawback of current cartilage- and intervertebral disc (IVD) tissue engineering is that human mesenchymal stem cells (MSCs) from patients with osteoarthritis rapidly express type X collagen (COL10A1), a marker of late stage chondrocyte hypertrophy associated with endochondral ossification.	20225218
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	In situ identification of putative cancer stem cells by multiplexing ALDH1, CD44, and cytokeratin identifies breast cancer patients with poor prognosis.	20228222
Neoplasms, Specialty Type - cancer, Aggressive behavior, Childhood Breast Carcinoma	Stem Cell Exhaustion	A subset of cells, tentatively called cancer stem cells (CSCs), in breast cancer have been associated with tumor initiation, drug resistance, and tumor persistence or aggressiveness.	20228222
Hematologic Neoplasms	Stem Cell Exhaustion	Allogenic haematopoietic stem cell transplantation (HCT) has become an effective therapy in patients with various haematological malignancies.	20228854
Hepatic Veno-Occlusive Disease	Stem Cell Exhaustion	Coagulation disturbances in paediatric patients with hepatic veno-occlusive disease after stem cells transplantation.	20229680
Hepatic Veno-Occlusive Disease, Venoocclusive disease	Stem Cell Exhaustion	Hepatic veno-occlusive disease (VOD) is a life threatening complication after stem cells transplantation (SCT).	20229680
Communicable Diseases	Stem Cell Exhaustion	In the absence of a protective immune response, human cytomegalovirus (HCMV) infection remains a life-threatening complication after allogeneic stem cell transplantation (SCT), especially in recipients of grafts from HCMV-seronegative donors.	20230226
B-Cell Lymphomas	Stem Cell Exhaustion	Effect of addition of rituximab to salvage chemotherapy on outcome of patients with diffuse large B-cell lymphoma relapsing after an autologous stem-cell transplantation.	20231299
B-Cell Lymphomas, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	We have investigated if rituximab-based salvage regimens improve response rates and survival of patients with diffuse large B-cell lymphoma (DLBCL) relapsing after an autologous stem-cell transplantation (ASCT).	20231299
Memory impairment, "Alzheimers Disease	Stem Cell Exhaustion	In this study, we investigated the efficacy of APalpha to promote neurogenesis in the hippocampal subgranular zone (SGZ), to reverse learning and memory deficits in 3-month-old male triple transgenic mouse model of Alzheimer's (3xTgAD) and the correlation between APalpha-induced neural progenitor cell survival and memory function in 3xTgAD mice.	20231471
Autonomic neuropathy, Amyloidosis	Stem Cell Exhaustion	Stem cell transplantation in patients with autonomic neuropathy due to primary (AL) amyloidosis.	20231668
Amyloidosis	Stem Cell Exhaustion	Patients with AL amyloidosis can benefit from high-dose chemotherapy and autologous stem cell transplantation (ASCT).	20231668
Autonomic neuropathy, Amyloidosis	Stem Cell Exhaustion	Patients with autonomic neuropathy secondary to AL amyloidosis can undergo autologous stem cell transplantation with relative safety.	20231668
Extrahepatic Cholangiocarcinoma	Stem Cell Exhaustion	Isolation and characterization of tumorigenic extrahepatic cholangiocarcinoma cells with stem cell-like properties.	20232394
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Recent studies suggest that the ability to form and grow tumors specifically resides in a small cell population called cancer stem cells (CSCs).	20232394
Malignant Neoplasms, Cholangiocarcinoma	Stem Cell Exhaustion	These studies were conducted mainly on various human cancers; however, isolation and characterization of stem cells from cholangiocarcinoma have not been attempted.	20232394
Extrahepatic Cholangiocarcinoma, Specialty Type - cancer	Stem Cell Exhaustion	In this study, we used these markers to identify a subpopulation of cells in extrahepatic cholangiocarcinoma (ECC) with cancer stem/progenitor cell-like properties.	20232394
Toxic effect, Multiple Myeloma	Stem Cell Exhaustion	A 3-day short course of palifermin before HDT reduces toxicity and need for supportive care after autologous blood stem-cell transplantation in patients with multiple myeloma.	20233744
Toxic effect, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We retrospectively determined whether a 3-day short course of palifermin could reduce the toxicity of high-dose therapy (HDT) and autologous blood stem-cell transplantation (ASCT) in patients with multiple myeloma (MM).	20233744
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Two-year clinical registry follow-up of endothelial progenitor cell capture stent versus sirolimus-eluting bioabsorbable polymer-coated stent versus bare metal stents in patients undergoing primary percutaneous coronary intervention for ST elevation myocardial infarction.	20236214
Acute myocardial infarction	Stem Cell Exhaustion	Endothelial progenitor cell (EPC) capture stent is designed to promote rapid endothelization and healing and is potentially useful in patients undergoing primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI).	20236214
Neoplasms, Malignant neoplasm of liver	Stem Cell Exhaustion	The results indicate that loss of heterozygosity of the tumor suppressor gene Tg737 may play an important role in the carcinogenetic mechanism of liver cancer stem cells.	20300861
Uremia	Stem Cell Exhaustion	Genomic damage in endothelial progenitor cells from uremic patients in hemodialysis.	20301080
Blood Vessel	Stem Cell Exhaustion	Patients undergoing hemodialysis show a reduced number and an impaired function of endothelial progenitor cells (EPCs), which in physiological conditions contribute to repair the vascular damage.	20301080
Hematologic Neoplasms, leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Donor KIR Genes 2DL5A, 2DS1 and 3DS1 are associated with a reduced rate of leukemia relapse after HLA-identical sibling stem cell transplantation for acute myeloid leukemia but not other hematologic malignancies.	20302958
Hematologic Neoplasms	Stem Cell Exhaustion	Stem cell transplantation (SCT) from a healthy donor can be curative for patients with hematologic malignancies resistant to other treatments.	20302958
SERPINB3 wt Allele, Malignant Neoplasms, Squamous cell carcinoma	Stem Cell Exhaustion	Squamous cell carcinoma (SCC) is among the most common secondary cancers after allogeneic stem cell transplantation (allo-SCT).	20302962
Respiratory Tract Infections, Malignant Neoplasms, Community-Acquired Infections	Stem Cell Exhaustion	Respiratory syncytial virus (RSV) is a common community-acquired virus that causes upper and lower respiratory tract infections in children, hematologic malignancy patients, and hematopoietic stem cell transplant (HSCT) recipients.	20304082
Complication Aspects, Abdominal Infection, Sepsis	Stem Cell Exhaustion	Five articles on Leuconostoc infections in transplant patients were found in PubMed including two liver recipients with intraabdominal infection due to biliary complications and four stem cell recipients with sepsis.	20305321
Multiple Myeloma	Stem Cell Exhaustion	He had been previously treated for IgA lambda multiple myeloma with chemotherapy, radiation, and autologous stem cell transplant.	20305517
Carcinoma of lung	Stem Cell Exhaustion	Progenitor stem cell marker expression by pulmonary carcinomas.	20305619
Malignant neoplasm of lung, Neoplasms	Stem Cell Exhaustion	We hypothesized that there is a differential distribution of progenitor cell markers among different histological types of lung cancers, with poorly differentiated tumors being more likely to express progenitor stem cell markers.	20305619
Carcinoma of lung	Stem Cell Exhaustion	Stem cell markers were detected in all histological types of pulmonary carcinomas.	20305619
Malignant neoplasm of lung	Stem Cell Exhaustion	Therefore, stem cell markers are expressed in lung cancers with different patterns seen for different histological types and degrees of differentiation.	20305619
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Plerixafor was recently approved by the US Food and Drug Administration (FDA) and the European Medicines Evaluation Agency (EMEA) to enhance stem cell mobilization for autologous transplant in patients with lymphoma and multiple myeloma.	20305700
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Plerixafor plus granulocyte CSF can mobilize hematopoietic stem cells from multiple myeloma and lymphoma patients failing previous mobilization attempts: EU compassionate use data.	20305700
Mycoses	Stem Cell Exhaustion	Invasive fungal infections (IFI) are a significant cause of morbidity and mortality in hematopoietic stem cell transplant (HSCT) recipients.	20307998
Anterior myocardial infarction	Stem Cell Exhaustion	Intracoronary infusion of selected autologous bone marrow stem cells improves longitudinal myocardial strain and strain rate in patients with old anterior myocardial infarction without recent revascularization.	20308191
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	For DLBCL relapse, 3-year EFS was 56% versus 18% with autologous stem-cell transplantation or not, respectively (P = .0661).	20308668
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	The outcome of patients with DLBCL at time of relapse remains poor, and aggressive treatment such as autologous stem-cell transplantation should be pursued whenever possible.	20308668
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	PURPOSE We investigated the effect on minimal residual disease, by qualitative and real-time quantitative polymerase chain reaction (RQ-PCR), of a consolidation regimen that included bortezomib, thalidomide, and dexamethasone (VTD) in patients with multiple myeloma (MM) responding to autologous stem-cell transplantation (auto-SCT).	20308672
Multiple Myeloma	Stem Cell Exhaustion	ThaDD plus high dose therapy and autologous stem cell transplantation does not appear superior to ThaDD plus maintenance in elderly patients with de novo multiple myeloma.	20331733
Toxic effect, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	With the aim to address the issue whether high-dose therapy (HDT) is required after new drugs combinations to improve outcome of elderly newly diagnosed multiple myeloma (MM) patients, we compared the toxicity and the outcome of ThaDD plus maintenance to those of ThaDD plus HDT-autologous stem cell transplantation (ASCT).	20331733
Neoplasms	Stem Cell Exhaustion	Immunostaining of these tumours further suggests they are derived from similar stem cells which show immunophenotypic features of both the proximal and distal nephron.	20332483
Malignant tumor of colon, Specialty Type - cancer	Stem Cell Exhaustion	Expansion of CD133(+) colon cancer cultures retaining stem cell properties to enable cancer stem cell target discovery.	20332776
Neoplasms	Stem Cell Exhaustion	Despite earlier studies demonstrating in vitro propagation of solid tumour cancer stem cells (CSCs) as non-adherent tumour spheres, it remains controversial as to whether CSCs can be maintained in vitro.	20332776
Congenital Abnormality	Stem Cell Exhaustion	These results rule out a direct function of Lrp5 in osteoblast progenitor cells and add further support to the notion that dysregulation of serotonin synthesis is involved in bone mass abnormalities observed in OPPG patients.	20333369
Acute GVH disease	Stem Cell Exhaustion	This study is the first to demonstrate that a genetic difference derived from HLA haplotype itself is associated with acute GVHD in allogeneic hematopoietic stem cell transplantation.	20335219
Prehypertension	Stem Cell Exhaustion	Prehypertension and endothelial progenitor cell function.	20336149
Acute myocardial infarction	Stem Cell Exhaustion	The objective of the present study was to evaluate the safety and feasibility of autologous bone marrow mesenchymal stem cell transplantation via such an approach in patients with acute myocardial infarction (AMI).	20337639
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	A novel approach to transplanting bone marrow stem cells to repair human myocardial infarction: delivery via a noninfarct-relative artery.	20337639
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Our previous study demonstrated a safe and efficient approach to delivering bone marrow stem cells via a noninfarcted artery in an animal myocardial infarction model.	20337639
Anaplastic ganglioglioma, S100A4 protein, human	Stem Cell Exhaustion	The expression of nestin may suggest that the origin or malignant transformation in anaplastic gangliogliomas is related to the undifferentiated neural stem cells.	20339274
Encephalitis	Stem Cell Exhaustion	Ganciclovir-resistant cytomegalovirus encephalitis in a hematopoietic stem cell transplant recipient.	20345320
Inflammation	Stem Cell Exhaustion	However, it remains unclear whether such abnormalities result from systemic inflammation or from abnormalities at stem cell level.	20346245
diabetic	Stem Cell Exhaustion	We hypothesized that clopidogrel treatment would result in a decrease in CEC number and increased activity of endothelial progenitor cell recruitment signaling pathways in diabetic patients.	20346323
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	In conclusion, clopidogrel reduces endothelial cell sloughing and increases expression of endothelial progenitor cell phosphorylated Akt and phosphorylated adenosine monophosphate kinase in the peripheral blood of patients with type 2 diabetes mellitus.	20346323
Parkinson Disease	Stem Cell Exhaustion	Intraarterial autologous implantation of adult stem cells for patients with Parkinson disease.	20346882
palladium, Parkinson Disease	Stem Cell Exhaustion	To evaluate the feasibility, safety, and effectiveness of intraarterial autologous implantation of adult stem cells for Parkinson disease (PD).	20346882
palladium	Stem Cell Exhaustion	From June 2006 to August 2008, 36 men and 14 women (mean age, 62.5 years +/- 10.4; range, 38-81 y) with PD (mean duration, 9.3 years; range, 1-28 y) underwent autologous implantation of stem cells with superselective arterial catheterization.	20346882
palladium	Stem Cell Exhaustion	Treatment of PD with intraarterial autologous implantation of adult stem cells is feasible and safe and results in improved severity of disease and QOL.	20346882
Kidney Failure, Diabetes, Heart Diseases	Stem Cell Exhaustion	However, progenitor cell elements contributing to this neovascularization are typically diminished in number and function in the elderly dysvascular patient, particularly in the presence of diabetes, renal insufficiency, and cardiac disease.	20347552
Heart failure	Stem Cell Exhaustion	To assess the safety and efficacy of the intracoronary infusion of CD133+ hematopoietic stem cells to improve ventricular function and quality of life in candidates for heart transplantation due to post-infarct chronic heart failure.	20347795
Heart failure, Premature ventricular contractions	Stem Cell Exhaustion	The intracoronary inoculation of CD133+ stem cells was safe and effective to improve ventricular contraction and symptomatic class function in patients with refractory post-infarct heart failure.	20347795
Thrombosis	Stem Cell Exhaustion	Leukocyte count and risk of thrombosis in patients undergoing haematopoietic stem cell transplantation or intensive chemotherapy.	20352161
Thrombosis	Stem Cell Exhaustion	We evaluated retrospectively the association of leukocyte counts and thrombosis in three cohorts of 100 patients each undergoing autologous or allogeneic haematopoietic stem cell transplantation or chemotherapy, respectively.	20352161
Noninfiltrating Intraductal Carcinoma	Stem Cell Exhaustion	The effect diminished one year later, suggesting that the progeny of patients' irradiated stem cells did not produce new daughter lymphocytes exhibiting DCI during the studied post-irradiation period.	20353337
Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	HIV status does not affect the outcome of autologous stem cell transplantation (ASCT) for non-Hodgkin lymphoma (NHL).	20353830
Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Randomized trials comparing autologous stem cell transplant (ASCT) to conventional chemotherapy have demonstrated superior survival among HIV-negative ASCT patients with relapsed non-Hodgkin lymphoma (NHL).	20353830
Graft-vs-Host Disease, Communicable Diseases	Stem Cell Exhaustion	Cytomegalovirus (CMV) infection and graft-versus-host disease (GVHD) are important complications after allogeneic hematopoietic stem cell transplantation (HSCT) with a clear link.	20353832
Reperfusion Injury	Stem Cell Exhaustion	Bone marrow-derived endothelial progenitor cells and endothelial cells may contribute to endothelial repair in the kidney immediately after ischemia-reperfusion.	20354148
Ischemia	Stem Cell Exhaustion	We hypothesized that bone marrow-derived (BMD) endothelial progenitor cells (EPCs) might play an important role in renal functional recovery after ischemia.	20354148
Neoplasms	Stem Cell Exhaustion	Metastasis-associated protein CD24 has been identified as a new prognostic factor and stem cell marker in the human neoplasm.	20354454
Monomorphic B-Cell Post-Transplant Lymphoproliferative Disorder, Neoplasms, Acute lymphocytic leukemia	Stem Cell Exhaustion	EBV-associated post-transplantation B-cell lymphoproliferative disorder following allogenic stem cell transplantation for acute lymphoblastic leukaemia: tumor regression after reduction of immunosuppression--a case report.	20356360
Post-transplant lymphoproliferative disorder, Lymphoproliferative Disorders	Stem Cell Exhaustion	Epstein-Barr virus (EBV)-associated B-cell post-transplantation lymphoproliferative disorder (PTLD) is a severe complication following stem cell transplantation.	20356360
Post-transplant lymphoproliferative disorder, Acute lymphocytic leukemia	Stem Cell Exhaustion	In support of this notion, reduction of immunosuppressive therapy may lead to regression of PTLD.We present a case of an 18-year-old male developing a monomorphic B-cell PTLD 2 months after receiving an allogenic stem cell transplant for acute lymphoblastic leukemia.	20356360
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: possible role of stromal-derived factor-1alpha.	20357375
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Vasculoprotective endothelial progenitor cells (EPCs) are regulated by stromal-derived factor-1alpha (SDF-1alpha) and are reduced in type 2 diabetes.	20357375
Neoplasms	Stem Cell Exhaustion	The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation.	20360385
Neoplasms	Stem Cell Exhaustion	Here we demonstrate that the nuclear receptor tailless (Tlx), which in the adult is expressed exclusively in astrocyte-like B cells of the subventricular zone, acts as a key regulator of neural stem cell (NSC) expansion and brain tumor initiation from NSCs.	20360385
Histogenic Process, Neoplasms	Stem Cell Exhaustion	Our study clearly demonstrates how NSCs contribute to brain tumorgenesis driven by a stem cell-specific transcription factor, thus providing novel insights into the histogenesis and molecular pathogenesis of primary brain tumors.	20360385
Neoplasms	Stem Cell Exhaustion	Tlx-induced NSC expansion and gliomagenesis are associated with increased angiogenesis, which allows for the migration and maintenance of brain tumor stem cells in the perivascular niche.	20360385
Acute leukemia	Stem Cell Exhaustion	Cytogenetic studies in acute leukemia patients relapsing after allogeneic stem cell transplantation.	20362228
Acute leukemia	Stem Cell Exhaustion	We analyzed karyotype stability in 22 patients with acute leukemia at relapse or disease progression after allogeneic stem cell transplantation (allo-SCT).	20362228
Coronary Arteriosclerosis	Stem Cell Exhaustion	Coincidence of moderately elevated N-terminal pro-B-type natriuretic peptide, endothelial progenitor cells deficiency and propensity to exercise-induced myocardial ischemia in stable angina.	20364046
Coronary Arteriosclerosis, Ischemia, Ventricular Dysfunction, Left	Stem Cell Exhaustion	To assess endothelial progenitor cells (EPC) counts, a novel prognostic marker, in relation to classical adverse outcome predictors - N-terminal pro-B-type natriuretic peptide (NT-proBNP), impaired left ventricular (LV) relaxation and exercise-induced ischemia - in stable coronary artery disease (CAD) with preserved LV systolic function.	20364046
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Autologous stem cell transplant (ASCT) is the standard of care for patients with relapsed diffuse large B-cell lymphoma (DLBCL).	20367136
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The highest expressed gene and microRNAs in R172 IDH2-mutated patients compared with the IDH1/IDH2wt patients were APP (previously associated with complex karyotype AML) and miR-1 and miR-133 (involved in embryonal stem-cell differentiation), respectively.	20368543
CLTC gene, Hemorrhagic cystitis	Stem Cell Exhaustion	Polyomavirus BK (BKV) is known as an important etiologic agent in the development of hemorrhagic cystitis (HC) after allogeneic stem cell transplant (SCT).	20370539
Purpura, Thrombotic Thrombocytopenic	Stem Cell Exhaustion	A significantly longer TTP was observed in patients who previously underwent allogeneic stem cell transplantation (12.5 months vs. 8 months; P = .036).	20371448
Evans syndrome, Multiple Myeloma	Stem Cell Exhaustion	Refractory Evans syndrome after autologous stem cell transplantation for multiple myeloma: management with a second transplantation.	20371959
Autoimmune Diseases, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The development of autoimmune disease after autologous stem cell transplantation (ASCT) is very rare in multiple myeloma (MM).	20371959
Adenocarcinoma of lung (disorder)	Stem Cell Exhaustion	We propose that half of immortal lung adenocarcinomas are derived from innately telomerase-positive stem cells, which might be the origin of CSCs, and that high telomerase activity with intact p16/Rb could be a marker of stem cell origin.	20372796
Malignant neoplasm of lung, Specialty Type - cancer	Stem Cell Exhaustion	Existence of cancer stem cells (CSCs) is still hypothetical and their practical marker is not available yet in lung cancer.	20372796
Age related macular degeneration, Chronic liver disease	Stem Cell Exhaustion	This conference report highlights selected presentations on big pharma's perspective on the field, stem cell-based therapies for chronic liver disease and age-related macular degeneration, and strategies to gain approval for the conduct of clinical trials involving stem cells.	20373250
Adult Glioblastoma	Stem Cell Exhaustion	We hypothesized that CD133+ glioblastoma cells presenting stem-cell properties may express pro-vascular molecules allowing them to form blood vessels de novo.	20375132
Hypertension, CTCAE	Stem Cell Exhaustion	Accelerated senescence of endothelial progenitor cells in hypertension is related to the reduction of calcitonin gene-related peptide.	20375903
Hypertension, CTCAE	Stem Cell Exhaustion	To explore whether the accelerated senescence of endothelial progenitor cells (EPCs) is related to the reduction of calcitonin gene-related peptide (CGRP) in hypertension.	20375903
Specialty Type - cancer	Stem Cell Exhaustion	Here, we discuss the implications of these discoveries for improving the safety and efficiency of iPSC generation, and for increasing our understanding of different aspects of basic biology-such as the control of pluripotency or the mechanisms involved in the generation of cancer stem cells.	20379220
Lymphoma	Stem Cell Exhaustion	Osteogenic potential of mesenchymal stem cells from bone marrow was found to be correlated with the expression of Dickkopf1 (DKK-1) in the bone marrow plasma and lymphoma cells before and after treatment.	20379806
Malignant tumor of colon, Malignant Neoplasms	Stem Cell Exhaustion	CD133 is one of the most important cancer-initiating (stem) cell markers and was confirmed to be expressed in solid cancers such as colon cancer.	20379837
Hepatitis B	Stem Cell Exhaustion	To investigate the frequency of occult hepatitis B, the clinical course of hepatitis B virus (HBV) reactivation and reverse seroconversion and associated risk factors in autologous hematopoietic stem cell transplantation (HSCT) recipients.	20380010
diabetic	Stem Cell Exhaustion	Adipose-tissue-derived mesenchymal stem cells (ASCs) derived from nondiabetic (nASCs) and diabetic (dASCs) donors were compared with regard to glucose metabolism, cell replication, apoptosis, and differentiation potential.	20380516
Diabetes	Stem Cell Exhaustion	These results indicate that in addition to involvement in insulin resistance, impaired function of mesenchymal stem cells that reside in adipose tissue as one of the major sources of adult stem cells might be responsible for complications related to diabetes type 2.	20380516
Stem Cell Factor, Azoospermia	Stem Cell Exhaustion	The transcription levels of stem cell factor (SCF) and c-kit were examined using real-time RT PCR in interstitial and intratubular cell fractions, as well as in tissue homogenates from normal, azoospermic and neoplasmic patients.	20384797
Toxic effect, Multiple Myeloma	Stem Cell Exhaustion	We studied in patients with multiple myeloma (MM) the efficacy, cost-effectiveness, and toxicity of a strategy of submyeloablative doses of Mel and stem cell support in the ambulatory setting, followed by a standard myeloablative dose transplant.	20385248
Glycogen storage disease type II	Stem Cell Exhaustion	Lentiviral gene therapy of murine hematopoietic stem cells ameliorates the Pompe disease phenotype.	20385789
Glycogen storage disease type II	Stem Cell Exhaustion	We have explored the potential of lentiviral vector-mediated expression of human acid alpha-glucosidase in hematopoietic stem cells (HSCs) in a Pompe mouse model.	20385789
Primary cerebral lymphoma	Stem Cell Exhaustion	Therapeutic drug monitoring for busulfan in plasma during conditioning chemotherapy for autologous stem cell transplantation in relapsed primary cerebral lymphoma.	20386358
Primary cerebral lymphoma	Stem Cell Exhaustion	Therapeutic drug monitoring for busulfan in plasma during conditioning chemotherapy for autologous stem cell transplantation in relapsed primary cerebral lymphoma has not previously been reported.	20386358
Peripheral Stem Cell Transplantation, Neoplasms	Stem Cell Exhaustion	[Case of far-advanced retroperitoneal extra-gonadal germ cell tumor responding to intensive treatment including multi-drug chemotherapy with peripheral blood stem cell transplantation and residual tumor removal].	20387517
Communicable Diseases	Stem Cell Exhaustion	From July 2002 to September 2009, 115 cases of graft occlusion were treated in 64 patients with lower extremity arterial bypass, including medical therapy for 8 cases and redo operations for 107 cases: graft thrombectomy alone for 32 cases, redo bypass operation with prosthetic grafts for 27 cases, graft thrombectomy plus balloon angioplasty for 17 cases, major amputation for 13 cases, graft thrombectomy plus endarterectomy for 10 cases, removal of occluded graft with infection for 4 case, distally bypass grafting with autologous saphenous vein for 3 case, and autologous stem cell transplanting for 1 case.	20388433
Multiple Myeloma	Stem Cell Exhaustion	During the 9 years after first diagnosis of myeloma in April 2000, our patient twice underwent an autologous stem cell transplantation and was also treated with the new substances bortezomib, thalidomide and lenalidomide.	20389145
Hematologic Neoplasms	Stem Cell Exhaustion	Haploidentical hematopoietic stem cell transplantation to adults with hematologic malignancies: analysis of 66 cases at a single Japanese center.	20390388
Hematologic Neoplasms	Stem Cell Exhaustion	Sixty-six adult patients with hematologic malignancies underwent haploidentical hematopoietic stem cell transplantation (haplo-HSCT) without T cell depletion.	20390388
Relapsing course	Stem Cell Exhaustion	Relapsed diffuse large B-cell lymphoma treated by reduced-intensity allogeneic stem cell transplantation with donor lymphocyte infusion.	20392389
Hematological Disease, Hyperferritinaemia	Stem Cell Exhaustion	Hyperferritinemia is associated with low incidence of graft versus host disease, high relapse rate, and impaired survival in patients with blood disorders receiving allogeneic hematopoietic stem cell grafts.	20393815
Acute leukemia	Stem Cell Exhaustion	Association of Human Development Index with rates and outcomes of hematopoietic stem cell transplantation for patients with acute leukemia.	20395416
Acute leukemia	Stem Cell Exhaustion	We evaluated the association of HDI with rates and outcomes of hematopoietic stem cell transplantation (HSCT) for patients with acute leukemia.	20395416
Graft-vs-Host Disease, Pneumonia, Interstitial	Stem Cell Exhaustion	Non-specific interstitial pneumonia as a manifestation of graft-versus-host disease following pediatric allogeneic hematopoietic stem cell transplantation.	20398200
Nonspecific interstitial pneumonia, Pneumonia, Interstitial, Fibrosis Assessment, Central neuroblastoma, bottle - unit dose	Stem Cell Exhaustion	Reported herein is a fibrosing non-specific interstitial pneumonia (NSIP) pattern together with BO in both lungs in an 8-year-old girl following a second allogeneic hematopoietic stem cell transplantation for relapsed neuroblastoma of adrenal origin.	20398200
Pneumothorax	Stem Cell Exhaustion	The course was complicated by bilateral pneumothoraces, and the patient underwent lung transplantation 3 years after the second stem cell transplantation.	20398200
Coronary heart disease	Stem Cell Exhaustion	[Changes of circulating endothelial progenitor cells in patients with coronary heart diseases before and after percutaneous coronary intervention].	20398557
Coronary heart disease, altretamine/cisplatin/cyclophosphamide protocol	Stem Cell Exhaustion	To compare circulating endothelial progenitor cells (EPCs) number between normal controls and patients with coronary heart diseases (CHD), and to explore the influence of percutaneous coronary intervention (PCI) on the number of EPCs in patients with CHD.	20398557
Carcinogenesis	Stem Cell Exhaustion	The expression of biliary lineage markers such as cytokeratin (K) 7 by hepatocytes is thought to reflect an altered regeneration pathway recruiting a stem cell compartment, more prone to carcinogenesis.	20399781
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	Outcome following Reduced-Intensity Allogeneic Stem Cell Transplantation (RIC AlloSCT) for relapsed and refractory mantle cell lymphoma (MCL): a study of the British Society for Blood and Marrow Transplantation.	20399879
Aggressive Non-Hodgkin Lymphoma, Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	Reduced-intensity allogeneic stem cell transplantation (RIC-AlloSCT) is being increasingly considered for patients with aggressive lymphoma, but limited evidence exists in mantle cell lymphoma (MCL).	20399879
Adult Myelodysplastic Syndrome, Communicable Diseases	Stem Cell Exhaustion	BM as a source of stem cells and myelodysplastic syndrome as the indication for transplantation were independently associated with higher risk of acquiring AdV infection.	20400984
Impaired T cell function	Stem Cell Exhaustion	Human umbilical cord blood (HUCB)-derived EPCs could be an alternative to rescue impaired stem cell function in the sick and elderly.	20404026
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Immunohistochemical expression of stem cell, endothelial cell, and chemosensitivity markers in primary glioma spheroids cultured in serum-containing and serum-free medium.	20404698
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Paraffin sections of the original surgical specimens, primary glioma spheroids, and U87 derived spheroids were stained immunohistochemically with the stem cell markers CD133, podoplanin, Sox2, Bmi-1, and nestin; the endothelial cell markers CD31, CD34, and Von Willebrand Factor (VWF); the chemosensitivity markers P-glycoprotein and tissue inhibitor of metalloproteinases-1 (TIMP-1); and glial fibrillary acidic protein, neural cell adhesion molecule CD56, and the proliferation marker Ki67.	20404698
Graft-vs-Host Disease	Stem Cell Exhaustion	Remission was achieved by treatment with the anti-CD52 monoclonal antibody, alemtuzumab, after which allogeneic stem-cell transplantation (with reduced-intensity conditioning treatment and graft-versus-host disease prophylaxis) resulted in a definitive cure.	20404855
Breast Carcinoma, Neoplasms	Stem Cell Exhaustion	Breast carcinomas have been reported to contain a subpopulation of CD44+/CD24- tumor cells with stem cell-like properties.	20405247
Breast Carcinoma	Stem Cell Exhaustion	The phenotypic profile of 139 breast carcinomas was investigated in paraffin sections using markers previously associated with stem cell-like properties (CD44, CD24), the "triple-state" (ER, PR, c-erb-B2), and angiogenesis (CD31).	20405247
Secondary Neoplasm, Neoplasms, Carcinoma of supraglottis	Stem Cell Exhaustion	The probable role of tumor stem cells for lymph node metastasis in supraglottic carcinoma.	20407935
Neoplasm Metastasis, Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Tumor stem cells (TSC), which are considered as likely candidates for the origin of cancer, are deduced to be responsible for tumor metastasis theoretically.	20407935
Hemorrhagic cystitis	Stem Cell Exhaustion	Hemorrhagic cystitis after allogeneic hematopoietic stem cell transplants is the complex result of BK virus infection, preparative regimen intensity and donor type.	20410183
Hemorrhagic cystitis	Stem Cell Exhaustion	Hemorrhagic cystitis is a common cause of morbidity after allogeneic stem cell transplantation, frequently associated with BK virus infection.	20410183
Hemorrhagic cystitis	Stem Cell Exhaustion	We hypothesized that patients with positive BK viruria before unrelated or mismatched related donor allogeneic hematopoietic stem cell transplantation have a higher incidence of hemorrhagic cystitis.	20410183
Hematologic Neoplasms	Stem Cell Exhaustion	To test this hypothesis, we prospectively studied 209 patients (median age 49 years, range 19-71) with hematologic malignancies who received bone marrow (n=78), peripheral blood (n=108) or umbilical cord blood (n=23) allogeneic hematopoietic stem cell transplantation after myeloablative (n=110) or reduced intensity conditioning (n=99).	20410183
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Monitoring of minimal residual disease by quantitative WT1 gene expression following reduced intensity conditioning allogeneic stem cell transplantation in acute myeloid leukemia.	20412098
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We compared outcomes by body mass index (BMI) for adult patients with acute myelogenous leukemia (AML) who underwent autologous (auto, n = 373), related donor (RD, n = 2041), or unrelated donor (URD, n = 1801) allogeneic myeloablative hematopoietic cell transplantation (HCT) using bone marrow or peripheral blood stem cells reported to the Center for International Blood and Marrow Transplant Research (CIBMTR) from 1995 to 2004.	20412867
Peripheral pulmonary artery stenosis	Stem Cell Exhaustion	CD34(+)CD133(+) cell and endothelial progenitor cell numbers were respectively determined by flow cytometry and cell culture, in peripheral vein and pulmonary artery blood.	20413531
Vascular System Injuries	Stem Cell Exhaustion	The respective abundance of circulating endothelial cells and endothelial progenitor cells may reflect the balance between vascular injury and repair.	20413531
Vascular System Injuries	Stem Cell Exhaustion	In conclusion, PAH, in contrast to CTEPH, is associated with markers of vascular injury (circulating endothelial cells, soluble E-selectin and sVCAM) but not with markers of remodelling (endothelial progenitor cells, CD34(+)CD133(+) cells and VEGF).	20413531
Cauda Equina	Stem Cell Exhaustion	[Cauda equina relapse after autologous stem cell transplantation in a patient with primary plasma cell leukemia].	20414040
Chronic Lymphocytic Leukemia, Cauda Equina	Stem Cell Exhaustion	We report a rare case showing involvement with the cauda equina after autologous peripheral blood stem cell transplantation for primary plasma cell leukemia (PCL).	20414040
Alopecia	Stem Cell Exhaustion	The pathogenesis of scarring alopecia is believed to be related to damage to stem cells within, and outside the confines of, the follicular bulge region.	20414092
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Interleukin-15 affects patient survival through natural killer cell recovery after autologous hematopoietic stem cell transplantation for non-Hodgkin lymphomas.	20414345
Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Natural killer cells at day 15 (NK-15), after autologous peripheral blood hematopoietic stem cell transplantation (APHSCT), is a prognostic factor for overall survival (OS) and progression-free survival (PFS) in non-Hodgkin lymphoma (NHL).	20414345
Ann Arbor Stage I Nasal Type NK/T-Cell Lymphoma	Stem Cell Exhaustion	Allogeneic haematopoietic stem cell transplantation as a salvage strategy for relapsed or refractory nasal NK/T-cell lymphoma.	20414818
Ann Arbor Stage I Nasal Type NK/T-Cell Lymphoma	Stem Cell Exhaustion	There are limited data about allogeneic haematopoietic stem cell transplantation (allo-HSCT) for relapsed or refractory nasal NK/T-cell lymphoma.	20414818
Graft-vs-Host Disease	Stem Cell Exhaustion	The stem cell source was peripheral blood for both patients, and there was no severe graft-versus-host disease in either patient.	20414818
Dental Pulp	Stem Cell Exhaustion	The biological examination of pulp injury, repair events and response of dental pulp stem cells to dental restorative materials is important to accomplish restorative treatment, especially to commonly used dental materials in paediatric dentistry, such as glass ionomer cement (GIC) and calcium hydroxide (Ca(OH)(2)) lining cement.	20415916
Multiple Myeloma	Stem Cell Exhaustion	Thalidomide maintenance therapy after stem cell transplantation resulted in increased progression-free survival and overall survival in a few trials, but its role in non-transplant eligible patients with multiple myeloma remains unclear.	20418244
Fibrous	Stem Cell Exhaustion	Marrow mesenchymal cells (MSCs) contain stem cells and possess the ability to regenerate bone, cartilage, and fibrous tissues.	20421856
Cytomegalovirus Infections	Stem Cell Exhaustion	Low-dose valganciclovir as preemptive therapy for cytomegalovirus infection occurring in allogeneic stem cell transplant recipients.	20424437
Hematologic Neoplasms	Stem Cell Exhaustion	Valganciclovir was used in 34 patients who underwent allogeneic stem cell transplantation for hematological malignancies at the dose of 900 mg oral administration/day (12 patients, group 1) or 1,800 mg oral administration/day (22 patients, group 2).	20424437
Stenotrophomonas maltophilia Measurement	Stem Cell Exhaustion	Clinical characteristics of Stenotrophomonas maltophilia infection in hematopoietic stem cell transplantation recipients: a single center experience.	20425134
Stenotrophomonas maltophilia Measurement, Infection	Stem Cell Exhaustion	Recipients of hematopoietic stem-cell transplantation (HSCT) are at high risk for infections caused by Stenotrophomonas maltophilia.	20425134
Ischemia	Stem Cell Exhaustion	Expression of nestin and glial-derived neurotrophic factor in human endogenous neural stem cells following ischemia.	20426902
Cerebral Infarction	Stem Cell Exhaustion	We investigated the relationship between glial cell line-derived neurotrophic factor (GDNF), nestin, and the activation of endogenous neural stem cells (NSCs) following cerebral infarction in humans.	20426902
Cerebral Infarction	Stem Cell Exhaustion	Our results indicate that, as in other mammals, proliferation of endogenous neural stem cells in the subventricular zone and subgranular zone of the hippocampus dentate gyrus of humans is activated by cerebral infarction and may be related to increases in GDNF expression.	20426902
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Although tyrosine kinase inhibitors is effective for dramatically reducing CML cells, it might be difficult to eradicate completely the CML stem cells.	20428337
Multiple Myeloma	Stem Cell Exhaustion	A staged approach with vincristine, adriamycin, and dexamethasone followed by bortezomib, thalidomide, and dexamethasone before autologous hematopoietic stem cell transplantation in the treatment of newly diagnosed multiple myeloma.	20428873
cytidylyl-(3-5)-cytidine	Stem Cell Exhaustion	This has been causally linked to an impaired endogenous regenerative capacity of circulating progenitor cells (CPC).	20430934
Hematological Disease	Stem Cell Exhaustion	Cell viability in peripheral blood progenitor cell (PBPC) grafts and its influence on the clinical course following transplantation was evaluated in 81 consecutive transplantations (72 autologous, 9 allogeneic) performed in patients with hematological diseases.	20432746
leukemia	Stem Cell Exhaustion	Institute of Clinical Chemistry, the first laboratory accredited for clinical cell analysis by flow cytometry in Croatia, participated in UKNEQAS for Leukocyte Immunophenotyping in 3 schemes: "Immune Monitoring", "CD34 Stem Cell Enumeration" and "Leukaemia Immunophenotyping".	20432753
Juvenile Myelomonocytic Leukemia	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment of JMML.	20432758
Malignant tumor of colon	Stem Cell Exhaustion	Endogenous miR-215 was elevated about 3-fold in CD133+HI/CD44+HI colon cancer stem cells that exhibit slow proliferating rate and chemoresistance compared to control bulk CD133+/CD44+ colon cancer cells.	20433742
Skin lesion, Mastocytosis	Stem Cell Exhaustion	Patients showing clonal BM MCs were grouped into indolent systemic mastocytosis without skin lesions (ISMs(-); n = 48) and other c-MCADs (n = 3)-both with CD25(++) BM MCs and either positive mast/stem cell growth factor receptor gene (KIT) mutation or clonal human androgen receptor assay (HUMARA) tests-and nc-MCAD (CD25-negative BM MCs in the absence of KIT mutation; n = 32) and compared for their clinical, biological, and molecular characteristics.	20434205
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Hematopoietic stem cell transplantation after posttransplant lymphoproliferative disorder.	20436718
Aplastic Anemia	Stem Cell Exhaustion	Aplastic anemia developed, and she received hematopoietic stem cell transplantation (HSCT).	20436718
Neoplasms	Stem Cell Exhaustion	Nestin, a neuronal stem cell marker was expressed in reverse Transcriptase-Polymerase Chain Reaction of both tumors.	20436722
diabetic, Diabetic Cardiomyopathies	Stem Cell Exhaustion	Different gene expression in human heart tissue and progenitor cells from control and diabetic subjects: relevance to the pathogenesis of human diabetic cardiomyopathy.	20437361
Heart failure, Coronary Arteriosclerosis, Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Moreover, we intend to characterize both in human myocardial tissue and in the related cardiac progenitor cells the pattern of gene expression and the levels of expression and protein activation of molecular effectors involved in the regulation of the myocardial function and differentiation to clarify whether in specific human pathological conditions (type 2 diabetes mellitus, cardiac failure, coronary artery disease) specific alterations of the aforementioned factors could take place.	20437361
Coronary Arteriosclerosis, Diabetic Cardiomyopathies	Stem Cell Exhaustion	As for the coronary artery disease, diabetic cardiomyopathy could be associated with a reduction of the cardiac stem and progenitor cells pool.	20437361
Neoplasms, HEY2 gene	Stem Cell Exhaustion	The hairy/enhancer of split (E(spl))-related family of transcription factors (HES and HEY) are established targets of the notch signaling pathway, which has been implicated in different developmental processes, tumor formation and the self-renewal of neural stem cells.	20437865
Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology	Stem Cell Exhaustion	Prior studies have shown that treatment of head and neck squamous cell carcinoma (HNSCC) patients with 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] reduced intratumoral levels of immune inhibitory CD34(+) progenitor cells while increasing levels of mature progeny dendritic cells.	20438786
Leukemia, Myelocytic, Acute, Cytopenia	Stem Cell Exhaustion	Two of these six patients developed AML indicating that a clonal stem cell disorder was the reason for the anteceding cytopenia, while there was no AML observed among the 17 patients with non-clonal patterns (P = 0.013).	20439346
Fibrosis Assessment, Primary Myelofibrosis	Stem Cell Exhaustion	Although allogeneic hematopoietic stem cell transplantation has recently been applied to patients with myelofibrosis with reproducible engraftment and resolution of marrow fibrosis, no data describe the outcomes of umbilical cord blood transplantation.	20439618
Leukoencephalopathy, Progressive Multifocal	Stem Cell Exhaustion	A WT1 mutation-associated gene-expression signature, reported here for the first time, included CD96, a leukemia stem cell-specific marker, and genes involved in gene regulation (eg, MLL, PML, and SNRPN) and in proliferative and metabolic processes (eg, INSR, IRS2, and PRKAA1), supporting the role of mutated WT1 in deregulating multiple homeostatic processes.	20442368
B-Cell Lymphomas	Stem Cell Exhaustion	High-dose therapy followed by autologous stem-cell transplantation with and without rituximab for primary treatment of high-risk diffuse large B-cell lymphoma.	20444844
Lymphoma	Stem Cell Exhaustion	A randomized controlled multicenter study comparing recombinant interleukin 2 (rIL-2) in conjunction with recombinant interferon alpha (IFN-alpha) versus no immunotherapy for patients with malignant lymphoma postautologous stem cell transplantation.	20445353
Lymphoma	Stem Cell Exhaustion	We have earlier shown an advantage in overall survival for malignant lymphoma (ML) patients who received combined Interleukin-2 (rIL-2) and interferon alpha (IFN-alpha) immunotherapy after autologous stem cell transplantation (AutoSCT) in comparison with historic controls.	20445353
Hematological Disease	Stem Cell Exhaustion	Treatment of the hematopoietic syndrome includes replacement with blood products, stem cell transplantation, and the use of hematopoietic cytokines.	20445391
Acute Radiation Syndrome	Stem Cell Exhaustion	Mesenchymal stem cell therapy for cutaneous radiation syndrome.	20445394
Defect	Stem Cell Exhaustion	Human mesenchymal stem cells and adipose-derived stem cells, together with angiogenic and mitogenic factor of basic fibroblast growth factor and an artificial dermis, were applied over the excised irradiated skin defect and were tested for differentiation and local stimulation effects in the radiation-exposed wounds.	20445394
Multiple Myeloma	Stem Cell Exhaustion	High complete remission rate and durable remissions achieved with rational use of autologous stem-cell transplantation, thalidomide maintenance, and non-myeloablative allogeneic transplantation in patients with multiple myeloma.	20447186
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem-cell transplantation (ASCT) has emerged as the standard approach in patients with multiple myeloma, although it is unlikely to achieve cure.	20447186
Retinal Diseases	Stem Cell Exhaustion	This study demonstrates that immortalized human fetal retinal progenitor cells retain their progenitor characteristics and may therefore have therapeutic potential in strategies that demand a renewable and consistent supply of donor cells for the treatment of degenerative retinal diseases.	20447347
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Over the last 20 years, high dose therapy followed by hemopoietic stem cell transplantation has been employed in patients with multiple myeloma (MM).	20450334
Neoplasms	Stem Cell Exhaustion	During 16 years of follow-up, the degree of tumor response and survival in 238 patients with autologous stem cell transplantation (ASCT) and changes in the serum protein electrophoretic pattern were analyzed.	20450334
Nodular Sclerosis Classical Hodgkin Lymphoma, Hodgkin Disease, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	A 58-year-old man with a remote history of diffuse large B-cell lymphoma (DLBCL), status post chemotherapy, radiation, and peripheral blood stem cell transplantation, presented with splenic nodular sclerosis classical Hodgkin lymphoma.	20451348
Colonization	Stem Cell Exhaustion	The dectin-1 Y238X polymorphism, which results in decreased Th17 responses, is associated with increased Candida colonization of stem cell transplantation (SCT) recipients.	20452827
nervous system disorder	Stem Cell Exhaustion	Exploitation of genetically modified neural stem cells for neurological disease.	20455497
nervous system disorder	Stem Cell Exhaustion	Neural stem cells (NSCs) have provided optimism for the horizon of therapeutic progress in treating neurological diseases.	20455497
Gastrointestinal Stromal Tumors	Stem Cell Exhaustion	The author concludes that all GISTs derive from stem cells in the gut retaining some of the differentiation potential seen in primitive gut cells.	20455665
Gastrointestinal Stromal Tumors	Stem Cell Exhaustion	Recent discovery of their expression of insulin-like growth factors may indicate that they represent persisting primitive gut cells (gut stem cells), which may serve as the progenitor cells to GIST.	20455665
Gastrointestinal Stromal Tumors, Smooth muscle (tissue)	Stem Cell Exhaustion	In this regard, it is important to note that the putative primordial cell of GIST, interstitial cells of Cajal (ICC), and intestinal smooth muscle cells have been shown to develop from the common progenitor cells of the primitive gut, and c-Kit plays a crucial role in the determination of their fate to differentiate to muscle cells or ICC.	20455665
Gastrointestinal Stromal Tumors, Neoplasms	Stem Cell Exhaustion	The author proposes that all GISTs develop from the common progenitor cells similar to primitive gut cells, which may differentiate into tumor cells with more myoid features in the stomach (similar to so-called ICC-DMP) as well as spindle cells with less myoid features (similar to ICC-MP [interstitial cells of Cajal associated with the myenteric plexus] in the small intestine and rectum).	20455665
Gastrointestinal Stromal Tumors, Neoplasms, Intestinal Neoplasms	Stem Cell Exhaustion	It is also pointed out that in this era of ICC and GIST pandemonium, a minority of intestinal stromal tumors with mature smooth muscle features have been totally ignored; these now appear to belong to GISTs, representing the best differentiated example among the tumors developing from the same progenitor cells.	20455665
Sample Size Calculation	Stem Cell Exhaustion	The clinical and laboratory data variations before and after rHuEPO treatment give new insights into the pathogenetic role of impaired endothelial stem-cell maturation and defective neoangiogenesis in patients with SSc.	20456380
Specialty Type - cancer	Stem Cell Exhaustion	The immature platelet fraction is a useful marker for predicting the timing of platelet recovery in patients with cancer after chemotherapy and hematopoietic stem cell transplantation.	20456520
Prehypertension, Endothelial dysfunction	Stem Cell Exhaustion	Impaired endothelial repair capacity of early endothelial progenitor cells in prehypertension: relation to endothelial dysfunction.	20458006
Coronary Artery Vasospasm	Stem Cell Exhaustion	This inhibition may increase endothelial progenitor cell apoptosis and decrease endothelial nitric oxide synthase/nitric oxide (eNOS/NO), thus leading to coronary spasm.	20458563
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We examined responses developing against CML66, an immunogenic antigen preferentially expressed in myeloid progenitor cells identified from a patient with chronic myelogenous leukemia who attained long-lived remission following CD4+ donor lymphocyte infusion (DLI).	20460482
Colorectal Neoplasms	Stem Cell Exhaustion	We found that Aurora-A is overexpressed in primary colorectal tumor cells, in the CR-CSC fraction, and in stem cell-derived differentiated cells, compared with normal colon tissue.	20460511
Colorectal Carcinoma	Stem Cell Exhaustion	Altogether, these results indicate that Aurora-A is essential for CR-CSC regeneration and resistance to cytotoxic stimuli and suggest that therapies directed against Aurora-A may effectively target the stem cell population in colorectal cancer.	20460511
Colorectal Carcinoma	Stem Cell Exhaustion	Aurora-a is essential for the tumorigenic capacity and chemoresistance of colorectal cancer stem cells.	20460511
Colorectal Carcinoma, Intestinal Neoplasms	Stem Cell Exhaustion	Colorectal cancer stem cells (CR-CSC) are responsible for the generation and maintenance of intestinal tumors and are highly resistant to conventional chemotherapeutic agents.	20460511
Hodgkin Disease	Stem Cell Exhaustion	The use of high-dose chemotherapy and autologous stem-cell transplantation in patients with relapsed Hodgkin's lymphoma is supported by two randomized clinical trials but its benefit in patients with primary refractory disease is less clear.	20460643
Hodgkin Disease	Stem Cell Exhaustion	Aiming to shed light on this issue, we analyzed and compared the outcomes of patients with relapsed or refractory Hodgkin's lymphoma treated with second-line chemotherapy and planned autologous stem-cell transplantation.	20460643
Hodgkin Disease	Stem Cell Exhaustion	We retrospectively analyzed data on 157 consecutive patients with Hodgkin's lymphoma referred to our institution for consideration of autologous stem-cell transplantation between 1999 and 2006.	20460643
Refractory Hodgkin Lymphoma	Stem Cell Exhaustion	Using the group with relapsed disease as a reference, we can conclude that the subset of patients with chemosensitive primary refractory Hodgkin's lymphoma do benefit from autologous stem-cell transplantation.	20460643
Adenocarcinoma of lung (disorder), Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem-like cells with bronchioalveolar stem cell properties in human lung adenocarcinoma were subdivided into two phenotypes: OCT4(+)BASC (SPC(+)CCSP(+)OCT4(+)) and OCT4(-)BASC (SPC(+)CCSP(+)OCT4(-)).	20462980
Adenocarcinoma of lung (disorder), Specialty Type - cancer	Stem Cell Exhaustion	The purpose of this study was to detect the presence of cancer stem-like cells with bronchioalveolar stem cells (BASCs) properties and investigate the clinicopathological role of expression of OCT4 as well as the correlation with clinical outcomes in adenocarcinoma of the lung.	20462980
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	The putative cancer stem cells in tumor sections were visualized immunofluorescently by using the antibodies against three bronchioalveolar stem cells markers: surfactant protein C (SPC), Clara cell secretary protein (CCSP) and Octamer-4 (OCT4).	20462980
Tetranitromethane	Stem Cell Exhaustion	Multivariate Cox's analysis reveals that pathological stages of TNM (P = 0.008) and bronchioalveolar stem cells phenotypes (P = 0.015) are the independent prognostic factors.	20462980
Adenocarcinoma of lung (disorder), Specialty Type - cancer	Stem Cell Exhaustion	The cancer cells with bronchioalveolar stem cells phenotype are detectable in adenocarcinoma of the lung and the expression of self-renewal regulatory gene OCT4 in these cells indicated the worse clinical outcomes.	20462980
Liver Cirrhosis, Hepatitis	Stem Cell Exhaustion	Acute hepatitis after autologous stem cell transplantation and rapid progression to liver cirrhosis.	20463583
Hepatitis, Hepatitis C	Stem Cell Exhaustion	During the period of a combined chemotherapy followed by autologous stem cell transplantation with multiple blood donations, an acute hepatitis without hepatitis C antibodies was diagnosed.	20463583
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Adoptive immunotherapy is an important therapy option to reduce relapse rates after stem-cell transplantation in patients suffering from acute myeloid leukemia and myelodysplastic syndromes.	20463595
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	To further elicit DC/DC(leu)-induced T-cell-response patterns, we generated DC from 17 Acute myeloid leukemia (AML) and 2 myelodysplastic syndrome cases and carried out flowcytometry and (functional) nonradioactive fluorolysis assays before/after mixed lymphocyte cultures of matched (allogeneic) donor T cells (n=6), T cells prepared at relapse after stem-cell transplantation (n=4) or (autologous) patients' T cells (n=7) with blast containing mononuclear cells ("MNC") or DC(leu) ("DC").	20463595
Malignant Neoplasms	Stem Cell Exhaustion	The Extracorporeal Life Support Organization Registry was queried for patients aged >or=21 years with diagnoses of malignancy or hematopoietic stem cell transplantation.	20466114
Hematologic Neoplasms, Neoplasms	Stem Cell Exhaustion	Seventy-two adults met inclusion criteria: 47 with solid tumors, 21 with hematologic malignancies, and 4 with hematopoietic stem cell transplantation.	20466114
Acquired disorder, Thrombophilia, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria is a rare acquired disorder of clonal hematopoietic stem cells and it is characterized as a hypercoagulable disorder.	20467181
Aggressive natural killer-cell leukemia	Stem Cell Exhaustion	[Aggressive NK-cell leukemia with sustained relapse-free survival after allogeneic peripheral blood stem cell transplantation].	20467222
Neoplasms, Malignant Glioma	Stem Cell Exhaustion	Side population (SP) cells identified using the Hoechst 33342 fluorescent dye efflux technique overlap with the tumor stem cell fraction that is responsible for tumorigenesis and recurrence in malignant gliomas.	20467330
Neoplasms	Stem Cell Exhaustion	We next performed immunohistochemistry to determinethe distribution patterns of erbB receptors among the main neuralcell types in the tumors with special reference to the putative tumor stem cell population.	20467331
Specialty Type - cancer, Glioblastoma	Stem Cell Exhaustion	Differential distribution of erbB receptors in human glioblastoma multiforme: expression of erbB3 in CD133-positive putative cancer stem cells.	20467331
Neoplasms	Stem Cell Exhaustion	Although erbB1 immunoreactivity was detected in only small subsets of CD133-positive putative tumor stem cells, erbB3 immunoreactivity was prominent in this population, suggesting that erbB3 may represent a new potential therapeutic target.	20467331
Neoplasms	Stem Cell Exhaustion	Mesenchymal stem cell (MSC)-like cells, a subpopulation of tumor microenvironment, have been isolated from several tumor tissues.	20473524
Thrombotic Microangiopathies, Chronic Kidney Disease, CTCAE	Stem Cell Exhaustion	A case of chronic kidney disease with thrombotic microangiopathy in a hematopoietic stem cell transplant recipient.	20473542
Renal function, Proteinuria, Acute lymphocytic leukemia	Stem Cell Exhaustion	A 23-year-old Japanese man who had undergone hematopoietic stem cell transplantation for acute lymphocytic leukemia from an HLA-identical sibling 6 years earlier developed proteinuria and impaired kidney function.	20473542
Multiple Myeloma	Stem Cell Exhaustion	Improved survival of multiple myeloma patients with late relapse after high-dose treatment and stem cell support, a population-based study of 348 patients in Denmark in 1994-2004.	20477864
TRPV6 wt Allele, Leukemia, T-Cell, Human T-lymphotropic virus 1	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HSCT) is increasingly used as a curative option for adult T-cell leukemia (ATL), an intractable mature T-cell neoplasm causally linked with human T-cell leukemia virus type I (HTLV-I).	20479287
Leukemia, T-Cell	Stem Cell Exhaustion	Transplantation of allogeneic hematopoietic stem cells for adult T-cell leukemia: a nationwide retrospective study.	20479287
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	He had previously been treated for non-Hodgkin lymphoma by autologous stem cell transplantation, as a result of which bone marrow function was reduced.	20482913
Idiopathic Pulmonary Fibrosis	Stem Cell Exhaustion	Investigation of bone marrow mesenchymal stem cells (BM MSCs) involvement in Idiopathic Pulmonary Fibrosis (IPF).	20483575
Idiopathic Pulmonary Fibrosis	Stem Cell Exhaustion	To probe the possible involvement of BM mesenchymal stem cells (MSCs) in the pathophysiology of Idiopathic Pulmonary Fibrosis (IPF) by investigating the molecular profile of these cells.	20483575
Congenital Bone Marrow Failure Syndromes	Stem Cell Exhaustion	We report a 6-year-old female with congenital bone marrow failure, who was referred for allogeneic stem cell transplantation.	20486183
Virus Diseases	Stem Cell Exhaustion	Low-dose cidofovir in the treatment of symptomatic BK virus infection in patients undergoing allogeneic hematopoietic stem cell transplantation: a retrospective analysis of an algorithmic approach.	20487411
JAK2 NP_004963.1:p.V617F, Primary Myelofibrosis	Stem Cell Exhaustion	Impact of JAK2V617F mutation status, allele burden, and clearance after allogeneic stem cell transplantation for myelofibrosis.	20489052
Primary Myelofibrosis	Stem Cell Exhaustion	Allogeneic stem cell transplantation (ASCT) after reduced-intensity conditioning has become a reasonable treatment option for patients with advanced myelofibrosis.	20489052
Substance	Stem Cell Exhaustion	Tissue regeneration in loss of substance on the lower limbs through use of platelet-rich plasma, stem cells from adipose tissue, and hyaluronic acid.	20489388
Graft-vs-Host Disease	Stem Cell Exhaustion	Ocular graft-versus-host disease after allogeneic stem cell transplantation.	20489577
Graft-vs-Host Disease	Stem Cell Exhaustion	To determine the prevalence and manifestations of ocular graft-versus-host disease (GvHD) after allogeneic stem cell transplantation (allo-SCT).	20489577
Cytomegalovirus Infections	Stem Cell Exhaustion	Immune reconstitution and cytomegalovirus infection after allogeneic stem cell transplantation: the important impact of in vivo T cell depletion.	20490728
Communicable Diseases	Stem Cell Exhaustion	We analyzed cytomegalovirus (CMV) infection risk factors and immune reconstitution kinetics in 89 patients after allogeneic stem cell transplantation (allo-SCT).	20490728
Kidney Failure, Chronic, Atherosclerosis	Stem Cell Exhaustion	Advanced glycation end products, carotid atherosclerosis, and circulating endothelial progenitor cells in patients with end-stage renal disease.	20494372
Kidney Failure, Chronic	Stem Cell Exhaustion	Numbers of endothelial progenitor cells (EPCs) have been shown to be decreased in subjects with end-stage renal disease (ESRD), the mechanism of which remained poorly understood.	20494372
Fanconi Anemia	Stem Cell Exhaustion	Fertility recovery and pregnancy after allogeneic hematopoietic stem cell transplantation in Fanconi anemia patients.	20494929
Gonadal structure, Infertility	Stem Cell Exhaustion	Most recipients of allogeneic hematopoietic stem cell transplantation suffer from secondary infertility owing to gonadal damage from myeloablative conditioning.	20494929
Fanconi Anemia	Stem Cell Exhaustion	Before hematopoietic stem cell transplantation all had confirmed Fanconi anemia diagnosis.	20494929
Fanconi Anemia	Stem Cell Exhaustion	In conclusion, recovery of normal ovarian function and a viable pregnancy is a realistic but relatively rare possibility even in Fanconi anemia patients following hematopoietic stem cell transplantation.	20494929
MYELODYSPLASTIC SYNDROME, Secondary Acute Myeloid Leukemia	Stem Cell Exhaustion	Value of allogeneic versus autologous stem cell transplantation and chemotherapy in patients with myelodysplastic syndromes and secondary acute myeloid leukemia.	20494931
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Allogeneic stem cell transplantation is usually considered the only curative treatment option for patients with advanced or transformed myelodysplastic syndromes in complete remission, but post-remission chemotherapy and autologous stem cell transplantation are potential alternatives, especially in patients over 45 years old.	20494931
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Patients with a donor and candidates for allogeneic stem cell transplantation in first complete remission may have a better disease-free survival than those without a donor in case of myelodysplastic syndromes with intermediate/high-risk cytogenetics.	20494931
Post-Traumatic Stress Disorder, Specialty Type - cancer	Stem Cell Exhaustion	To study posttraumatic growth and psychological and physical well-being among 25 cancer survivors (12 men, 13 women) 9 years after receiving a hematopoietic stem cell transplant from an unrelated donor.	20496975
Lymphoma	Stem Cell Exhaustion	Phase II study of immunomodulation with granulocyte-macrophage colony-stimulating factor, interleukin-2, and rituximab following autologous stem cell transplant in patients with relapsed or refractory lymphomas.	20496994
Aggressive Non-Hodgkin Lymphoma, Chemosensitivity	Stem Cell Exhaustion	High-dose chemotherapy followed by autologous stem cell transplant (ASCT) leads to durable remissions in approximately half of patients with chemosensitive relapsed or refractory aggressive lymphomas; however, many will relapse despite ASCT secondary to persistent minimal residual disease (MRD) or malignant graft contamination.	20496994
Specialty Type - cancer	Stem Cell Exhaustion	The aberrant asynchronous replication - characterizing lymphocytes of cancer patients - is erased following stem cell transplantation.	20497575
Hematologic Neoplasms, Aneuploidy	Stem Cell Exhaustion	The study aimed at following the epigenetic markers and aneuploidy levels in cells of patients with haematological malignancies from diagnosis to full remission, as achieved by allogeneic stem cell transplantation (alloSCT).	20497575
Ischemia	Stem Cell Exhaustion	Combination stem cell therapy for the treatment of severe limb ischemia: safety and efficacy analysis.	20498146
Degenerative polyarthritis	Stem Cell Exhaustion	Large-scale gene expression in bone marrow mesenchymal stem cells: a putative role for COL10A1 in osteoarthritis.	20498197
Degenerative polyarthritis	Stem Cell Exhaustion	To elucidate disease-specific molecular changes occurring in osteoarthritis (OA) by analysing the differential gene expression profiles of bone marrow mesenchymal stem cells (BM-MSCs) from patients with OA compared with those without OA.	20498197
Endometrial Carcinoma	Stem Cell Exhaustion	The expression of prostate stem cell antigen (PSCA), piwi-like 1 (PIWIL1), and T-box 2 (TBX2) in endometrial cancer remains to be elucidated.	20502058
Ischemic stroke	Stem Cell Exhaustion	A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke.	20506226
Ischemic stroke	Stem Cell Exhaustion	We previously evaluated the short-term follow-up preliminary data of mesenchymal stem cells (MSCs) transplantation in patients with ischemic stroke.	20506226
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Randomized comparison of endothelial progenitor cells capture stent versus cobalt-chromium stent for treatment of ST-elevation myocardial infarction.	20506282
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	The aim of this trial was to assess the feasibility and safety of endothelial progenitor cells capture (EPC) stent in the treatment of acute ST-elevation myocardial infarction (STEMI) when compared with cobalt-chromium stents (CoCr).	20506282
Primary chondrosarcoma of bone, Neoplasms	Stem Cell Exhaustion	Human primary chondrosarcoma cells, articular chondrocytes, mesenchymal stem cells, fibroblasts, and a panel of tumor cell lines from chondrocytic or epithelial origin were clustered based on the expression profile of eleven surface markers.	20506378
Chondrosarcoma	Stem Cell Exhaustion	By selecting clustering approaches shown to give reproducible results for cluster recovery of known cell types, primary conventional central chondrosacoma cells could be grouped in two main clusters with distinctive marker expression signatures: one group clustering together with mesenchymal stem cells (CD49b-high/CD10-low/CD221-high) and a second group clustering close to fibroblasts (CD49b-low/CD10-high/CD221-low).	20506378
Cessation of life, Malignant Neoplasms	Stem Cell Exhaustion	Patients with FA had earlier onset of cancers, need for stem cell transplant, and death; followed by DC; DBA and SDS were mildest.	20507306
Cytomegalovirus Infections	Stem Cell Exhaustion	Immune monitoring with iTAg MHC Tetramers for prediction of recurrent or persistent cytomegalovirus infection or disease in allogeneic hematopoietic stem cell transplant recipients: a prospective multicenter study.	20508161
Communicable Diseases	Stem Cell Exhaustion	Cytomegalovirus (CMV) infection is an important cause of morbidity and mortality in hematopoietic stem cell transplant recipients despite the introduction of posttransplantation viral monitoring and preemptive antiviral therapy.	20508161
Inflammation, Atrial Fibrillation by ECG Finding	Stem Cell Exhaustion	Circulating progenitor cells in patients with atrial fibrillation and their relation with serum markers of inflammation and angiogenesis.	20508899
Corneal Endothelial Cell Loss	Stem Cell Exhaustion	Circulating progenitor cells (CPCs) have been recently described as a cell population that may promote repair of endothelial damage.	20508899
Graft-vs-Host Disease	Stem Cell Exhaustion	Minor histocompatibility antigens influence the occurrence of graft-vs.-host disease and graft-vs.-leukemia effects after hematopoietic stem cell transplantation (HSCT).	20509834
Liver carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Immunohistochemical staining of cancer stem cell markers in hepatocellular carcinoma.	20511115
Specialty Type - cancer, Chronic liver disease	Stem Cell Exhaustion	The use of cancer stem cell markers to screen tissues with chronic liver diseases provides limited guidance in the identification of malignant cells.	20511115
Specialty Type - cancer, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Cancer stem cells (CSCs) are thought to be a critical subpopulation in tumor development, progression, metastasis and recurrence, and the identification of these cells is an initial step in understanding their role in oncogenesis and in seeking valuable markers for diagnosis or development of targeting therapeutics.	20511115
Neutropenia, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Pegfilgrastim appears equivalent to daily dosing of filgrastim to treat neutropenia after autologous peripheral blood stem cell transplantation in patients with non-Hodgkin lymphoma.	20511163
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Patients with diffuse large B-cell lymphoma (DLBCL) who are not cured by initial therapy sometimes experience disease-free survival after autologous stem cell transplantation.	20511164
Childhood Ependymoma, Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	A clinically relevant orthotopic xenograft model of ependymoma that maintains the genomic signature of the primary tumor and preserves cancer stem cells in vivo.	20511191
Neoplasms, Ependymoma	Stem Cell Exhaustion	The xenograft tumors shared nearly identical histopathological features with the original tumors, harbored 8 structural chromosomal abnormalities as detected with spectral karyotyping, maintained gene expression profiles resembling that of the original patient tumor with the preservation of multiple key genetic abnormalities commonly found in human ependymomas, and contained a small population (<2.2%) of CD133(+) stem cells that can form neurospheres and display multipotent capabilities in vitro.	20511191
Lupus Erythematosus, Encephalitis, St. Louis	Stem Cell Exhaustion	Systemic lupus erythematosus (SLE) has been considered as stem cell disorder.	20511276
Lupus Erythematosus	Stem Cell Exhaustion	Defective phenotype of mesenchymal stem cells in patients with systemic lupus erythematosus.	20511276
Encephalitis, St. Louis	Stem Cell Exhaustion	The objective of this study was to examine the phenotype, growth and immunomodulatory effect of mesenchymal stem cells (MSCs) from SLE patients compared with those from age- and sex-matched healthy donors.	20511276
Cytomegalovirus Infections	Stem Cell Exhaustion	Kinetics of cytomegalovirus (CMV) pp65 and IE-1-specific IFNgamma CD8+ and CD4+ T cells during episodes of viral DNAemia in allogeneic stem cell transplant recipients: potential implications for the management of active CMV infection.	20513086
Peripheral Blood Stem Cells, Multiple Myeloma	Stem Cell Exhaustion	A Phase II study of (153)Sm-EDTMP and high-dose melphalan as a peripheral blood stem cell conditioning regimen in patients with multiple myeloma.	20513117
Neoplasms	Stem Cell Exhaustion	Exposure of human and murine stem-like brain tumour cells to neurosphere-derived bone morphogenetic protein-7 induces tumour stem cell differentiation, attenuates stem-like marker expression and reduces self-renewal and the ability for tumour initiation.	20513660
Urinary Stress Incontinence	Stem Cell Exhaustion	Human cord blood stem cell therapy for treatment of stress urinary incontinence.	20514298
Urinary Stress Incontinence	Stem Cell Exhaustion	Our objective in this study was to evaluate the safety and efficacy of transurethral cord blood stem cell injection for treatment of stress urinary incontinence in women.	20514298
Urinary Stress Incontinence	Stem Cell Exhaustion	Our results suggest that transurethral umbilical cord blood stem cell injection is an effective treatment for women with all types of stress urinary incontinence.	20514298
Cryoglobulinemia	Stem Cell Exhaustion	Endothelial progenitor cells in mixed cryoglobulinemia.	20516023
Diffuse alveolar hemorrhage, Encephalitis, St. Louis	Stem Cell Exhaustion	Mesenchymal stem cell transplantation for diffuse alveolar hemorrhage in SLE.	20517294
Multiple Myeloma	Stem Cell Exhaustion	High-dose melphalan (Alkeran) and autologous stem cell transplantation are commonly incorporated into the initial line of therapy for patients newly diagnosed with multiple myeloma.	20518365
Multiple Myeloma	Stem Cell Exhaustion	No survival advantage of autologous stem cell transplantation (ASCT) has been documented for patients older than 65 years, and in the era of thalidomide (Thalomid), bortezomib (Velcade), and lenalidomide (Revlimid), ASCT has a diminished role in the front-line treatment of older patients with myeloma.	20518366
neurofibroma, Neurofibromatoses	Stem Cell Exhaustion	Nestin-positive stem cells in neurofibromas from patients with neurofibromatosis type 1-tumorigenic or incidental?	20520523
neurofibroma	Stem Cell Exhaustion	Although we found no difference in melanogenic cells in neurofibromas from patients with NF1 relative to the sporadic group, we did find a significant population of nestin-positive progenitor cells in neurofibromas from patients with NF1.	20520523
neurofibroma	Stem Cell Exhaustion	In light of recent evidence linking formation of neural neoplasms such as neurofibroma to alterations in the self-renewal program of stem/progenitor cells, our findings reinforce the potentially tumorigenic role of nestin-positive progenitor cells in neurofibromas from patients with NF1.	20520523
Microalbuminuria, Hypertensive (finding)	Stem Cell Exhaustion	Increased circulating CD31+/annexin V+ apoptotic microparticles and decreased circulating endothelial progenitor cell levels in hypertensive patients with microalbuminuria.	20520578
Microalbuminuria, Cardiovascular Diseases	Stem Cell Exhaustion	Here, we tested the hypothesis that enhanced endothelial apoptotic microparticles and decreased endothelial progenitor cell (EPC) levels might contribute to the pathophysiology of microalbuminuria or macroalbuminuria in cardiovascular disease.	20520578
Neoplasms, Medulloblastoma	Stem Cell Exhaustion	Explanations of this very unusual association include radio-induced tumors, second tumors developing from remnants of medulloblastoma cancer stem cells, or the changing histology after adjuvant therapy.	20522094
Up, Dental Plaque	Stem Cell Exhaustion	Our results provide a foundation for an adult stem cell-based therapy to suppress soluble Abeta peptide and plaque accumulation in the cerebrum of patients with AD.	20522650
Peripheral Stem Cell Transplantation, Seminoma	Stem Cell Exhaustion	Salvage chemotherapy with high-dose carboplatin and etoposide with peripheral blood stem cell transplant in patients with relapsed pure seminoma.	20523207
Peripheral Stem Cell Transplantation, Seminoma	Stem Cell Exhaustion	To evaluate rates of complete remission and overall survival for patients with relapsed pure seminoma treated with high-dose carboplatin and etoposide followed by peripheral blood stem cell transplant.	20523207
Seminoma	Stem Cell Exhaustion	Forty-eight consecutive patients with relapsed pure seminoma who were treated with high-dose chemotherapy (HDCT) and autologous peripheral blood stem cell transplant between May 1996 and June 2006 were retrospectively reviewed.	20523207
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Since MCF-7 cells are representative of cancer cells that do not readily undergo apoptosis, consideration of senescence pathways may play a role in targeting stem cells from such tumors.	20525204
Endothelium	Stem Cell Exhaustion	In this study we analyzed direct markers of endothelial injury, circulating endothelial cells (CECs) and endothelial microparticles (EMPs), and endothelial progenitor cells (EPCs) as a marker of endothelial repair in patients after CPR.	20525353
Cerebrovascular accident	Stem Cell Exhaustion	In this study, we demonstrated that implantation of human umbilical cord mesenchymal stem cells (hUCMSCs) cultured in human umbilical cord serum (hUCS) significantly enhanced neuroplasticity and angiogenesis in stroke and ischemic limb models.	20525429
Hodgkin Disease	Stem Cell Exhaustion	Long-term results of high-dose chemotherapy with autologous bone marrow or peripheral stem cell transplant as first salvage treatment for relapsed or refractory Hodgkin lymphoma: a single institution experience.	20528244
Failure, HD Term Type, Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	The introduction of high-dose (HD) chemotherapy (CT) and autologous stem cell (ASCT) or bone marrow transplant (ABMT) in the last two decades has improved the prognosis of patients with refractory or relapsed Hodgkin lymphoma (HL) over conventional-dose salvage CT. To evaluate the outcome of adult patients with HL treated with HD CT and ASCT or ABMT after failure or relapse from first-line treatment with CT +/- radiotherapy, we report the results of a retrospective analysis in 82 consecutive patients given HD CT and autologous transplant as second-line therapy between October 1984 and December 2006.	20528244
PAFAH1B1 wt Allele	Stem Cell Exhaustion	The only potentially curative treatment for MDS is hematopoietic stem cell transplantation, which often is not an option because of advanced age at diagnosis (median age = 76 years).	20529786
PAFAH1B1 wt Allele, Hematological Disease, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are a group of heterogeneous clonal disorders of myeloid hematopoietic stem cells affecting about 300,000 people worldwide.	20529786
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	On December 15, 2008, the US Food and Drug Administration approved plerixafor (Mozobil; Genzyme Corp.), a new small-molecule inhibitor of the CXCR4 chemokine receptor, for use in combination with granulocyte colony-stimulating factor (G-CSF) to mobilize hematopoietic stem cells (HSC) to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM).	20530974
Alpha1 Significance, Prostate carcinoma	Stem Cell Exhaustion	Alpha1 and beta1 integrins enhance the homing and differentiation of cultured prostate cancer stem cells.	20531279
Prostate carcinoma	Stem Cell Exhaustion	CD133(+) prostate cancer stem cells (PCSCs) have recently been identified in human prostate cancer tissues.	20531279
Prostate carcinoma	Stem Cell Exhaustion	Our analysis of the expression of surface integrins and their adhesion patterns of prostate cancer stem cells derived from prostate cancer tissues revealed that the levels of beta(1) and alpha(2)beta(1) integrins were significantly higher (P < 0.05) than those of the other integrins.	20531279
Prostate carcinoma	Stem Cell Exhaustion	The present study reports the integrin profile of prostate cancer progenitor cells and the role of alpha(1) and beta(1) integrins in the homing and differentiation of PCSCs in vitro.	20531279
varicella zoster, Gammaherpesvirinae	Stem Cell Exhaustion	Lymphoproliferative response to herpes simplex virus type 1, cytomegalovirus, Epstein-Barr virus, varicella zoster virus, human herpes virus 6, 7, and 8 antigen stimulation in pediatric allogeneic stem cell transplant recipients.	20534025
Herpes	Stem Cell Exhaustion	Choice of donor and stem cell source were important determinants of eventual LPR to various herpes viruses at 3-month post-transplant.	20534025
Acute myocardial infarction	Stem Cell Exhaustion	Endothelial progenitor cells and left ventricle function in patients with acute myocardial infarction: potential therapeutic considertions.	20535003
Multiple Myeloma	Stem Cell Exhaustion	We are the first to prospectively explore single agent bortezomib as primary therapy (induction, maintenance and re-induction) without consolidative autologous stem cell transplant in a cohort selected to have high-risk multiple myeloma.	20535147
Therapy-related acute myeloid leukemia and myelodysplastic syndrome	Stem Cell Exhaustion	Treatment of therapy-related myeloid neoplasms with high-dose cytarabine/mitoxantrone followed by hematopoietic stem cell transplant.	20536346
Rupture, Amyloidosis	Stem Cell Exhaustion	Spontaneous rupture of the liver in a patient with systemic AL amyloidosis undergoing treatment with high-dose melphalan and autologous stem cell transplantation: a case report with literature review.	20536404
Rupture, Amyloidosis	Stem Cell Exhaustion	A 55-year-old woman with primary Immunoglobulin light chain (AL) systemic amyloidosis died due to spontaneous rupture of her liver following treatment with high-dose melphalan and autologous stem cell transplant (HDM/SCT).	20536404
Hair follicle structure, melanoma	Stem Cell Exhaustion	In the present study, we examined the expression of the hair follicle and neural stem cell marker nestin, as well as S-100 and HMB-45, in melanoma.	20536663
Hair follicle structure	Stem Cell Exhaustion	Nestin, a marker of neural stem cells, is expressed in the stem cells of the mouse hair follicle.	20536663
Fracture	Stem Cell Exhaustion	Circulating plastic adherent mesenchymal stem cells in aged hip fracture patients.	20540091
Fracture	Stem Cell Exhaustion	We examined the presence of circulating plastic adherent multipotent mesenchymal stem cells (MSCs) in fracture patients.	20540091
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic graft-versus-host disease (cGVHD) associated morbidity and mortality remain major barriers for successful allogeneic hematopoietic stem cell transplantation (alloHSCT).	20541028
FLT3 Internal Tandem Duplication	Stem Cell Exhaustion	Further studies are required to determine whether the degree of leukemic stem cell expansion (CD45+CD123+cells) increases the risk of acquisition of FLT3-ITD and/or provides selective advantages.	20542566
MS gene	Stem Cell Exhaustion	Characterization of in vitro expanded bone marrow-derived mesenchymal stem cells from patients with multiple sclerosis.	20542920
MS gene	Stem Cell Exhaustion	Recent studies have investigated the potential of autologous bone marrow-derived mesenchymal stem cells (MSCs) as a therapy for multiple sclerosis.	20542920
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Granulocytic sarcoma of the stomach: relapse after hematopoietic stem-cell transplantation for chronic myeloid leukemia.	20543544
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	An 18-year-old male underwent an allogeneic hematopoietic stem cell transplantation (allo-HSCT) for chronic myeloid leukemia (CML) in the first late chronic phase.	20543544
diabetic	Stem Cell Exhaustion	Relationship of microparticles to progenitor cells as a measure of vascular health in a diabetic population.	20544836
Mycoses	Stem Cell Exhaustion	Disseminated fungal infection is a major cause of morbidity and mortality in children undergoing hematopoietic stem cell transplantation (HSCT).	20546908
Busulfan/Melphalan Regimen	Stem Cell Exhaustion	Recommended treatment consisted of six cycles of vincristine, ifosfamide, doxorubicin, and etoposide (VIDE), one cycle of vincristine, dactinomycin, and ifosfamide (VAI), local treatment (surgery and/or radiotherapy), and high-dose busulfan-melphalan followed by autologous stem-cell transplantation (HDT/SCT).	20547982
Infarction	Stem Cell Exhaustion	Administration of multipotent stem cell (MSC) into such infarct may regenerate the myocardium and capillary network.	20552656
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Transcoronary infusion of bone marrow derived multipotent stem cells to preserve left ventricular geometry and function after myocardial infarction.	20552656
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Transcoronary infusion of bone marrow derived multipotent stem cells into infarcted related artery after acute myocardial infarction is feasible, safe and improve left ventricular function.	20552656
Hematologic Neoplasms, Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	Standard- versus high-dose lenograstim in adults with hematologic malignancies for peripheral blood progenitor cell mobilization.	20553434
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Monosomal karyotype provides better prognostic prediction after allogeneic stem cell transplantation in patients with acute myelogenous leukemia.	20553926
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We studied cytogenetic risk grouping schemes to stratify patients with acute myelogenous leukemia (AML) (n = 212) into prognostically distinct subgroups for relapse incidence (RI), progression-free survival (PFS), and overall survival (OS) after allogeneic hematopoietic stem cell transplantation (HSCT).	20553926
Osteoporosis, Postmenopausal	Stem Cell Exhaustion	An increased number of circulating osteoprogenitor cells (OPCs) expressing bone-related proteins and the stem cell marker CD34 have been identified in women with postmenopausal osteoporosis, who also have stiffer arteries than nonosteoporotic subjects.	20554181
Cytomegaloviral gastritis	Stem Cell Exhaustion	Endoscopic diagnosis of cytomegalovirus gastritis after allogeneic hematopoietic stem cell transplantation.	20556837
Gastritis	Stem Cell Exhaustion	To clarify the endoscopic and clinical findings of cytomegalovirus (CMV) gastritis after allogeneic hematopoietic stem cell transplantation (allo-SCT).	20556837
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Post-transplant immune reconstitution after unrelated allogeneic stem cell transplant in patients with acute myeloid leukemia.	20557144
Acute leukemia	Stem Cell Exhaustion	Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis.	20558104
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Relapse of acute myelogenous leukemia has been associated with clonal cytogenetic evolution, but no study focused specifically on relapse after allogeneic hematopoietic stem cell transplantation (HSCT).	20558312
Complex Karyotype	Stem Cell Exhaustion	Thus, higher frequencies of clonal evolution and increasing cytogenetic complexity were observed in the stem cell recipients probably related to the more unfavorable cytogenetic profiles already depicted at diagnosis.	20558312
Chronic myeloproliferative disorder, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myelogenous leukemia (CML) is a myeloproliferative disease that originates in abnormal pluripotent bone marrow stem cells and it is consistently associated with the Philadelphia chromosome and/or BCR/ ABL fusion gene.	20558931
Heart failure	Stem Cell Exhaustion	Stem cell therapy has emerged as a promising approach to improve healing of the infarcted myocardium, to treat or prevent cardiac failure, and to restore lost cardiac function.	20560029
Acute myocardial infarction, Ventricular Dysfunction, Left	Stem Cell Exhaustion	COMPARE-AMI trial: comparison of intracoronary injection of CD133+ bone marrow stem cells to placebo in patients after acute myocardial infarction and left ventricular dysfunction: study rationale and design.	20560029
Electrocardiogram: myocardial infarction (finding), Ventricular Dysfunction, Acute myocardial infarction	Stem Cell Exhaustion	COMPARE-acute myocardial infarction (AMI) study is a phase II, randomized, double-blind, placebo-controlled trial evaluating the safety and effectiveness of intracoronary CD133(+)-enriched hematopoietic bone marrow stem cells in patients with acute myocardial infarction and persistent left ventricular dysfunction.	20560029
Multiple Myeloma	Stem Cell Exhaustion	Interaction between KIR3DS1 and HLA-Bw4 predicts for progression-free survival after autologous stem cell transplantation in patients with multiple myeloma.	20562327
Multiple Myeloma	Stem Cell Exhaustion	High rate of stem cell mobilization failure after thalidomide and oral cyclophosphamide induction therapy for multiple myeloma.	20562926
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Novel agents are increasingly used during induction therapy for multiple myeloma (MM), but there is concern about their potential impact on stem cell mobilization.	20562926
Hematopoietic Stem Cell Mobilization	Stem Cell Exhaustion	In this retrospective review of 136 patients with newly diagnosed MM, we show that the combination of thalidomide and oral CY with dexamethasone (CTD) during induction therapy impaired stem cell mobilization substantially.	20562926
Hematologic Neoplasms, Neoplasms	Stem Cell Exhaustion	The feasibility and safety of immunotherapy mediated by intentionally mismatched rIL-2 activated killer lymphocytes (IMAK) with no prior stem cell engraftment was investigated in patients with advanced chemotherapy-resistant hematological malignancies and metastatic solid tumors.	20563804
Multiple Myeloma, Lymphoma, Morular Metaplasia of the Endometrium, leukemia	Stem Cell Exhaustion	The purpose of the current study was to determine whether the use of hematopoietic stem cell transplantation (HCT) to treat leukemia, lymphoma, or multiple myeloma (MM) differs by race and sex.	20564154
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	This single-center retrospective study determined the efficacy of bortezomib, thalidomide, and dexamethasone (BTD) as induction for patients with multiple myeloma (MM) who were eligible for autologous stem cell transplantation (ASCT).	20564642
Specialty Type - cancer	Stem Cell Exhaustion	Patients with symptomatic MM who had received BTD induction before stem cell collection at Winship Cancer Institute were included.	20564642
Muscle Rigidity	Stem Cell Exhaustion	Rigidity increased as the result of stem cell therapy alone, but was insufficient for penetration.	20565373
Erectile dysfunction, Diabetes Mellitus	Stem Cell Exhaustion	Human umbilical cord blood stem cell therapy has positive effects on erectile dysfunction and diabetes mellitus.	20565373
Erectile dysfunction	Stem Cell Exhaustion	Stem cells are characterized by self renewal and multipotent differentiation.We report the effects of intracavernosal transplant of human umbilical cord blood stem cells on diabetic erectile dysfunction.	20565373
POEMS Syndrome, Peripheral Stem Cell Transplantation, Endocrine System Diseases, Gammopathy, Polyneuropathy, Organomegaly	Stem Cell Exhaustion	To investigate skin manifestations of the polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome and their correlation with serum vascular endothelial growth factor (s-VEGF-A) levels and to describe the impact of autologous peripheral blood stem cell transplantation (aPBSCT) on these manifestations and the correlation with s-VEGF-A levels.	20566924
Hypertrophy, Degenerative polyarthritis, Endochondral Ossification	Stem Cell Exhaustion	A major drawback of current cartilage and intervertebral disc tissue engineering is that human mesenchymal stem cells (MSCs) from osteoarthritic (OA) patients express type X collagen (COL10), a marker of late-stage chondrocyte hypertrophy (associated with endochondral ossification).	20569194
Neutropenia, Malignant Neoplasms	Stem Cell Exhaustion	Malignancy (76.7%), neutropenia (64.1%), allogeneic hematopoietic stem cell transplantation (HSCT, 22.3%), solid organ transplantation (8.7%), autologous HSCT (4.9%), and HIV/AIDS (2.9%) were the most common underlying conditions.	20569436
Thrombocytosis, Myeloproliferative disease, Primary Myelofibrosis, Thrombosis, Polycythemia Vera, Bone marrow hypercellularity	Stem Cell Exhaustion	The classic myeloproliferative neoplasms--essential thrombocytosis, polycythemia vera, and primary myelofibrosis--are acquired, clonal hematopoietic stem cell disorders characterized by an overproduction of mature blood cells, bone marrow hypercellularity, extramedullary hematopoiesis, a tendency for thrombosis, and, rarely, leukemic transformation.	20571018
Medulloblastoma	Stem Cell Exhaustion	At the age of 11, the patient underwent an MRI-confirmed incomplete resection of a fourth-ventricle medulloblastoma, followed by conventional chemotherapy, craniospinal irradiation (55.8 Gy, 1.8 Gy/fraction) and then myeloablative chemotherapy followed by peripheral blood progenitor cell rescue.	20572594
melanoma	Stem Cell Exhaustion	CD133 and ABCB5 as stem cell markers on sentinel lymph node from melanoma patients.	20573479
Burn injury, Limbal stem cell deficiency	Stem Cell Exhaustion	Ocular burns may destroy the limbus, causing limbal stem-cell deficiency.	20573916
Herpes Zoster Ophthalmicus, Limbal stem cell deficiency	Stem Cell Exhaustion	We investigated the long-term clinical results of cell therapy in patients with burn-related corneal destruction associated with limbal stem-cell deficiency, a highly disabling ocular disease.	20573916
Injury of cornea, Limbal stem cell deficiency	Stem Cell Exhaustion	We used autologous limbal stem cells cultivated on fibrin to treat 112 patients with corneal damage, most of whom had burn-dependent limbal stem-cell deficiency.	20573916
Burn injury	Stem Cell Exhaustion	Cultures of limbal stem cells represent a source of cells for transplantation in the treatment of destruction of the human cornea due to burns.	20573916
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Properties of CD34+ CML stem/progenitor cells that correlate with different clinical responses to imatinib mesylate.	20574046
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We recently identified several features of CML CD34(+) stem/progenitor cells expected to confer resistance to BCR-ABL-targeted therapeutics.	20574046
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Thus, 2 properties of pretreatment CML stem/progenitor cells correlate with subsequent response to IM therapy.	20574046
Specialty Type - cancer	Stem Cell Exhaustion	This data has implications for the modulation of redox states in cancer stem cells, which are thought to be resistant to therapy due to their low ROS states.	20574517
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	No curative treatment exists for patients with myelodysplastic syndrome (MDS) besides allogeneic stem cell transplantation.	20574731
Chronic heart failure	Stem Cell Exhaustion	The acute and long-term effects of intracoronary Stem cell Transplantation in 191 patients with chronic heARt failure: the STAR-heart study.	20576835
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Long term follow-up of allogeneic stem cell transplantation in patients with myelodysplastic syndromes using busulfan, cytosine arabinoside, and cyclophosphamide.	20578198
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We report here the 10-year follow-up of 86 patients who underwent allogeneic stem cell transplantation (ASCT) for myelodysplastic syndrome (MDS).	20578198
Peripheral Blood Stem Cells	Stem Cell Exhaustion	The median CD34 yield in patients attempting peripheral blood stem cell (PBSC) collection following this regimen was 10.9 x 10(6) CD34+ cells/kg (range 5.0-24.1 x 10(6)).	20578815
Spondylarthritis	Stem Cell Exhaustion	Undifferentiated spondyloarthritis following allogeneic stem cell transplantation.	20579362
Malignant Neoplasms, Rheumatism	Stem Cell Exhaustion	Stem cell transplant has been utilized in the treatment of malignancies and rheumatic disease.	20579362
Dactylitis	Stem Cell Exhaustion	After a thorough history and physical exam, it was noted that our patient had developed signs of axial disease along with dactylitis and overall that he had been insidiously developing an undifferentiated spondyloarthopathy after allogeneic stem cell transplantation.	20579362
Rheumatism	Stem Cell Exhaustion	Our observation supports the hypothesis that de novo rheumatic disease can develop after stem cell transplant for a variety of reasons.	20579362
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) represent a heterogeneous group of clonal hematopoietic stem cell disorders that are preferentially diagnosed in the elderly.	20580567
Graft-vs-Host Disease, Chronic graft-versus-host disease, Lymphoproliferative Disorders	Stem Cell Exhaustion	The monoclonal anti-CD20 antibody Rituximab (RTX) is increasingly used in allogeneic stem cell transplantation (SCT) to treat lymphoproliferative disorders and chronic graft-versus-host disease (GVHD).	20580848
Neoplasms	Stem Cell Exhaustion	We propose that this function is conserved and that tumour growth and stem cell behaviour rely on the status of a functional GLI1-NANOG-p53 network.	20581802
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53.	20581802
Multiple Myeloma	Stem Cell Exhaustion	Phase II trial of high-dose topotecan, melphalan and CY with autologous stem cell support for multiple myeloma.	20581887
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	The effect of age on the efficacy of human mesenchymal stem cell transplantation after a myocardial infarction.	20583954
Ischemic cardiomyopathy	Stem Cell Exhaustion	Here, we evaluated the effects of donor age on the function of human mesenchymal stem cells (hMSCs) in the context of cell therapy for ischemic cardiomyopathy.	20583954
Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Reduced-intensity conditioning allogeneic stem cell transplant for relapsed or transformed aggressive B-cell non-Hodgkin lymphoma.	20583964
Lymphoma, Non-Hodgkin, Familial, Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	The role of reduced-intensity conditioning allogeneic stem cell transplant (RIC allo-SCT) in aggressive B-cell non-Hodgkin lymphoma (NHL) remains a matter of debate.	20583964
Childhood Breast Carcinoma	Stem Cell Exhaustion	Based on their ability to generate senescent progeny under low-density clonogenic conditions, we classified breast cancer cell lines as senescent cell progenitor (SCP) and immortal cell progenitor (ICP) subtypes.	20585577
Childhood Non-Hodgkin Lymphoma, Myeloma cell, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The concentration of CD44 is increased in hematopoietic stem cell grafts of patients with acute myeloid leukemia, plasma cell myeloma, and non-Hodgkin lymphoma.	20586634
Hematologic Neoplasms	Stem Cell Exhaustion	We measured CD44 in 157 hematopoietic stem cell grafts from patients with hematologic malignancies and from 43 healthy donors by enzyme-linked immunosorbent assay.	20586634
CLU protein, human	Stem Cell Exhaustion	In an effort to understand the clinical benefit provided by stem cells therapy in patients with CLI, we characterized the marrow-derived stromal cells of CLI patients and we provided a correlation between the in vitro features of these cells and the clinical follow up at 12 months.	20587143
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	However, chronic myeloid leukemia (CML) is rarely complicated by the NS, and it occurs usually after allogenic stem cell transplantation or interferon alpha therapy for CML.	20587884
Parkinson Disease	Stem Cell Exhaustion	Our observations suggest strategies for avoiding and treating graft-induced dyskinesias that result from cell therapies for Parkinson's disease with fetal tissue or stem cells.	20592420
Arteriosclerosis of carotid artery, Hypertension, CTCAE	Stem Cell Exhaustion	[The relationship between the level of circulating endothelial progenitor cells CD34+; and carotid artery arteriosclerosis in youth and middle aged patients with essential hypertension].	20594475
Blood Vessel, Hypertension, CTCAE	Stem Cell Exhaustion	To explore the relationship between the level of circulating endothelial progenitor cells (EPCs) CD34+ with the Framingham cardiovascular risk factors, or with the carotid artery intima-media thickness (IMT), and to evaluate the value of circulating EPCs CD34+ level as a cytological marker of early vascular lesion in youth and middle aged essential hypertension (EH) patients.	20594475
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Recent data suggest that proper assessment of comorbidities is useful to predict the outcome of MDS patients receiving allogeneic stem cell transplantation.	20594593
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the German CLL Study Group CLL3X trial.	20595516
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	The purpose of this prospective multicenter phase 2 trial was to investigate the long-term outcome of reduced-intensity conditioning allogeneic stem cell transplantation (alloSCT) in patients with poor-risk chronic lymphocytic leukemia.	20595516
Colorectal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	CD133 has been described as a marker for cancer stem cells (CSCs) in colorectal cancer.	20596619
Liver carcinoma, HCCS gene, Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	CD133 antigen has been used to identify cancer stem cells in several solid tumor types, including hepatocellular carcinomas (HCCs).	20596644
Infection	Stem Cell Exhaustion	Early infections in the stem cell transplant recipients at AIIMS, New Delhi: a prospective study.	20601334
Neutropenia, Infection	Stem Cell Exhaustion	The pattern of infections in neutropenic patients including those undergoing stem cell transplant in the west has changed but the same may not be the case in the developing countries as brought out through some earlier observations in some transplant centers in India.	20601334
Infection	Stem Cell Exhaustion	To determine the frequency and pattern of infections in haemopoietic stem cell transplant (HSCT) recipients at this center in India.	20601334
Joints	Stem Cell Exhaustion	Safety of autologous bone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months.	20603892
Carcinoma, Chronic graft-versus-host disease	Stem Cell Exhaustion	A case of tongue carcinoma associated with chronic graft-versus-host disease after allogeneic haematopoietic stem cell transplantation.	20604764
Immunocompromised Host	Stem Cell Exhaustion	In the context of the severely immunocompromised state of the patient and her need for allogeneic hematopoietic stem cell transplantation (HSCT), surgical treatment options were not favored.	20604906
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	Short imatinib pulses were added to chemotherapy to improve the long-term survival of adult patients with Philadelphia chromosome (Ph) -positive acute lymphoblastic leukemia (ALL), to optimize complete remission (CR) and stem-cell transplantation (SCT) rates.	20606084
CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology	Stem Cell Exhaustion	Information on the treatment of AA was available in 49 patients: 38 received only immunosuppressive therapy (IST), 8 patients underwent hematopoietic stem cell transplantation (HSCT) - 6 as first-line therapy and 2 after failure of IST - whilst 3 patients had a spontaneous recovery.	20606411
Colorectal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer.	20606680
Colorectal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	The aim of this study was to elucidate the prognostic impact of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and aldehyde dehydrogenase-1 (ALDH1) in colorectal cancer.	20606680
Depression, CTCAE, Anxiety Disorders	Stem Cell Exhaustion	depression and anxiety) is a strong predictor of functional status and other aspects of quality of life in autologous stem cell transplantation following high-dose chemotherapy.	20609251
Hematologic Neoplasms, Psychological Distress	Stem Cell Exhaustion	The aim is to evaluate the outcome of stepped care for psychological distress on functional status and other aspects of quality of life in patients with hematological malignancy treated with autologous stem cell transplantation.	20609251
Hematologic Neoplasms	Stem Cell Exhaustion	First, the outcome of the intervention for psychological distress in patients with hematological malignancy treated with autologous stem cell transplantation is evaluated in a randomized controlled study.	20609251
Retinoblastoma	Stem Cell Exhaustion	Initially, retinoblastoma protein (pRB) was linked to cell cycle regulation, but it also regulates senescence, apoptosis, autophagy, differentiation, genome stability, immunity, telomere function, stem cell biology, and embryonic development.	20610631
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) comprise a heterogeneous group of clonal stem-cell disorders characterized by ineffective hematopoiesis and risk of progression to acute myeloid leukemia.	20613786
Neutropenia, palladium	Stem Cell Exhaustion	A mechanism-based population PD model was developed to describe neutropenia and the final model consisted of (1) a drug-sensitive uncommitted progenitor cell compartment (2) three transit compartments, and (3) a circulating neutrophil compartment with feedback mechanism.	20614121
Odontogenesis	Stem Cell Exhaustion	[Tooth development disturbances following haematopoietic stem cell transplantation].	20614798
Hematologic Neoplasms	Stem Cell Exhaustion	Forty children treated with allogenic haematopoietic stem cell transplantation for haematological malignancies, were examined at least 2 years after transplantation.	20614798
Hematologic Neoplasms	Stem Cell Exhaustion	We investigated the role of sCD30 in 30 patients undergoing allogeneic hematopoietic stem cell transplantation for hematologic malignancies.	20620210
Graft-vs-Host Disease	Stem Cell Exhaustion	We suggest a potential role of sCD30 serum levels in prediction of aGvHD following allogeneic stem cell transplantation.	20620210
Hypernatremia	Stem Cell Exhaustion	Iron overload is an important problem in candidates for and survivors of hematopoietic stem cell transplantation (HSCT), and affects long-term outcome and survival.	20620535
Hematologic Neoplasms	Stem Cell Exhaustion	High-dose chemotherapy with autologous stem cell transplantation (ASCT) is curative treatment in various hematologic malignancies.	20623783
Acute leukemia	Stem Cell Exhaustion	Hematopoietic stem-cell transplantation for acute leukemia in relapse or primary induction failure.	20625136
Acute leukemia	Stem Cell Exhaustion	Patients with acute leukemia refractory to induction or reinduction chemotherapy have poor prognoses if they do not undergo hematopoietic stem-cell transplantation (HSCT).	20625136
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	A multicenter trial evaluated two or three weekly infusions of yttrium-90 ((90)Y) epratuzumab tetraxetan (humanized anti-CD22 antibody) in 64 patients with relapsed/refractory NHL, including 17 patients who underwent prior autologous stem-cell transplantation (ASCT).	20625137
Malignant Neoplasms	Stem Cell Exhaustion	Underlying conditions analyzed included hematopoietic stem cell transplant (HSCT; 18%), hematologic malignancy (HM; 60%), chronic immunosuppression (CI; 12%), or other condition (OC; 10%).	20625156
Angina Pectoris	Stem Cell Exhaustion	This study explored the clinical significance of CD34(+)/133(+) circulating progenitor cell (CPC) counts in patients with stable angina pectoris (AP) who underwent percutaneous coronary intervention (PCI).	20625217
Angina Pectoris	Stem Cell Exhaustion	Circulating CD34+/133+ progenitor cells in patients with stable angina pectoris undergoing percutaneous coronary intervention.	20625217
Bronchiolitis Obliterans, Graft-vs-Host Disease, Acute lymphocytic leukemia	Stem Cell Exhaustion	We describe a 15- year-old patient who underwent cut-down lobar lung transplant for end-stage obliterative bronchiolitis secondary to GVHD that had developed as a result of haematopoietic stem cell transplantation for childhood acute lymphoblastic leukaemia.	20626714
Malignant Neoplasms	Stem Cell Exhaustion	Among 386 CBTs, which were first myeloablative stem cell transplantations for malignancies and used a single unit of cord blood, 89 tested positive.	20628152
Chronic Kidney Disease, CTCAE	Stem Cell Exhaustion	Endothelial progenitor cells and cardiovascular events in patients with chronic kidney disease--a prospective follow-up study.	20628606
Aspergillosis	Stem Cell Exhaustion	Impact of prior invasive aspergillosis on outcome in patients receiving reduced-intensity conditioning allogeneic hematopoietic stem cell transplant.	20629522
Hematologic Neoplasms, Aspergillosis	Stem Cell Exhaustion	Invasive aspergillosis (IA) is a major cause of morbidity in patients with hematological malignancies, and a major impediment to the success of allogeneic stem cell transplant (allo-SCT).	20629522
Hypoxia	Stem Cell Exhaustion	Hypoxia suppressed the osteo/odontogenic differentiation of hDPCs in vitro and increased the number of cells expressing STRO-1, an early mesenchymal stem cell marker.	20630496
Lymphoma, Follicular, Lymphoma, Neoplasms	Stem Cell Exhaustion	Rather than the follicular lymphomas typical of vavP-BCL-2 mice, aging vavP-Mcl-1 mice were primarily susceptible to lymphomas having the phenotype of a stem/progenitor cell (11 of 30 tumors) or pre-B cell (12 of 30 tumors).	20631380
Adenocarcinoma of lung (disorder), Aggressive behavior	Stem Cell Exhaustion	Sox2 is a marker of embryonic stem cell pluripotency that is associated with aggressive tumor behavior and is expressed in a subset of lung adenocarcinomas.	20631605
Gammopathy, Amyloidosis	Stem Cell Exhaustion	AL amyloidosis with IgD-lambda monoclonal gammopathy and lambda-type Bence-Jones protein: successful treatment by autologous stem cell transplantation.	20632063
Congestive heart failure, Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Recent advances in stem cell therapy to restore cardiac function have great promise for patients with congestive heart failure after myocardial infarction in an adult population.	20632394
Congestive heart failure, Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	We present our first case of transcoronary autologous stem cell transplantation in a 9-year-old girl with refractory congestive heart failure secondary to myocardial infarction 1 year after transcatheter revascularization.	20632394
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Transcoronary bone marrow-derived progenitor cells in a child with myocardial infarction: first pediatric experience.	20632394
Heart Diseases	Stem Cell Exhaustion	This is the first reported pediatric case of successful transcoronary injection of bone marrow-derived progenitor cells for end-stage heart disease.	20632394
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Characterization of ncRNAs in progenitor cells and stromal cells of MDS patients could be strategic for understanding gene expression regulation in this disease.	20633296
Thalassemia	Stem Cell Exhaustion	A cost-utility and budget impact analysis of allogeneic hematopoietic stem cell transplantation for severe thalassemic patients in Thailand.	20633303
Thalassemia	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) is the only curative treatment available to severe thalassemic patients.	20633303
Hematologic Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	The presence of two different abnormal cell lines at diagnosis in hematologic malignancies is rare and raises the question of etiology and pathogenesis--two separate malignant lineages occurring together or a common stem cell malignancy?	20633764
Histiocytosis, Langerhans-Cell	Stem Cell Exhaustion	ECD and LCH may have a close association with divergent differentiation from the same stem cells under different microenvironmental conditions.	20633799
Mycoses	Stem Cell Exhaustion	Voriconazole for secondary prophylaxis of invasive fungal infections in allogeneic stem cell transplant recipients: results of the VOSIFI study.	20634495
Mycoses	Stem Cell Exhaustion	Recurrence of prior invasive fungal infection (relapse rate of 30-50%) limits the success of stem cell transplantation.	20634495
Mycoses	Stem Cell Exhaustion	A prospective, open-label, multicenter trial was conducted evaluating voriconazole (4 mg/kg/12 h intravenously or 200 mg/12 h orally) as secondary antifungal prophylaxis in allogeneic stem cell transplant recipients with previous proven or probable invasive fungal infection.	20634495
Mycoses	Stem Cell Exhaustion	Voriconazole appears to be safe and effective for secondary prophylaxis of systemic fungal infection after allogeneic stem cell transplantation.	20634495
B-Cell Lymphomas	Stem Cell Exhaustion	High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is a recognized treatment option for patients with relapsed diffuse large B-cell lymphoma.	20635327
Immune-mediated	Stem Cell Exhaustion	Immune-mediated cytopenias after allogeneic stem cell transplantation can be categorized as either alloimmune when host or donor immunity reacts against donor or host elements, respectively, or autoimmune when donor immunity reacts against donor hematopoietic tissue, owing to poorly understood mechanisms that result in severe impairment of central and peripheral tolerance.	20635972
Specialty Type - cancer	Stem Cell Exhaustion	In this study, the safety of donor-derived long-term ex vivo-expanded human NK and NK-like T cells given as DLIs was investigated as immunotherapy for cancer in five patients following allogeneic stem cell infusion.	20636021
Diabetes Mellitus, Fibrosis Assessment, Neoplasms, Immunocompromised Host, Hematologic Neoplasms	Stem Cell Exhaustion	Twenty-six were immunocompromised, as follows: haematological malignancy (18) with allogeneic stem cell transplantation (16/18), solid tumour (three), solid organ transplantation (two), diabetes mellitus (two) and cystic fibrosis (one).	20636432
Bacteremia	Stem Cell Exhaustion	Risk factors for enterococcal bacteremia in allogeneic hematopoietic stem cell transplant recipients.	20636482
Bacteremia	Stem Cell Exhaustion	Bacteremia is a well known cause of morbidity and mortality in hematopoietic stem cell transplant (HSCT) recipients and enterococci are among the most frequently isolated pathogens.	20636482
Pregnancy Complications, Infectious	Stem Cell Exhaustion	Donor lymphocyte infusions (DLIs) are used for adoptive immunotherapy to prevent or treat relapse and infectious complications after allogeneic hematopoietic stem cell transplantation (HSCT).	20637880
Multiple Myeloma	Stem Cell Exhaustion	The optimal mobilization strategy prior to autologous stem cell transplantation for patients with multiple myeloma remains unclear.	20637882
Multiple Myeloma	Stem Cell Exhaustion	VP-16 and G-CSF appears to be a safe and effective mobilization regimen for patients with multiple myeloma undergoing autologous stem cell transplantation, producing excellent stem cell yield with the majority of patients requiring 1 day of apheresis.	20637882
Bone necrosis	Stem Cell Exhaustion	We examined the apoptosis of circulating endothelial progenitor cells in MM subjects before and after BP treatment and in osteonecrosis patients using a flow-cytometric analysis.	20639624
Specialty Type - cancer	Stem Cell Exhaustion	High telomerase activity is one distinct cancer stem cell feature and the here described cellular constructs in combination with stem cell markers like CD133, Aldehyddehydrogenase-1 (ALDH-1) or Side population (SP) may help to investigate the impact of telomerase activity on cancer stem cell survival under therapy.	20642823
Anemia, Sickle Cell	Stem Cell Exhaustion	RH genotyping in a sickle cell disease patient contributing to hematopoietic stem cell transplantation donor selection and management.	20644109
Alzheimers Disease	Stem Cell Exhaustion	Alzheimer's disease modifies progenitor cell expression of monoamine oxidase B in the subventricular zone.	20648649
Up, "Alzheimers Disease	Stem Cell Exhaustion	Because the very high expression of monoamine oxidase B (MAO-B) in the subventricular area has been related to epithelial and astroglial expression, we sought to ascertain whether it was also expressed by progenitor cells of human control and Alzheimer's disease (AD) patients.	20648649
Up	Stem Cell Exhaustion	In the early AD stages, the discrete MAO-B reduction, different from the severe GFAP decrease, would reflect the capacity of this population of MAO-B-positive progenitor cells to adapt to the neurodegenerative process.	20648649
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	CD133 expression in cancer cells has been recognised as a putative cancer stem cell (CSC) marker in epithelial malignancies.	20651407
Hypoalbuminemia, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Severe hypoalbuminemia at day 90 predicts worse nonrelapse mortality and overall survival after allogeneic hematopoietic stem cell transplantation for acute myelogenous leukemia and myelodysplastic syndrome.	20655389
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Hematopoietic stem cell transplantation for T315I-mutated chronic myelogenous leukemia.	20657522
Fanconi Anemia	Stem Cell Exhaustion	Haploidentical stem cell transplantation as a salvage therapy for cord blood engraftment failure in a patient with Fanconi anemia.	20658637
Fanconi Anemia, Primary graft failure	Stem Cell Exhaustion	A 7-year-old male with Fanconi Anemia who developed primary graft failure following one antigen-mismatched unrelated cord blood transplantation and a nonradiation-based conditioning, underwent a second hematopoietic stem cell transplantation (HSCT) from his 2-loci mismatched haploidentical father, using a nonradiation-based regimen, 79 days after the first HSCT.	20658637
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Salvage chemotherapy followed by high-dose therapy and autologous stem-cell transplantation (ASCT) is the standard treatment for relapsed diffuse large B-cell lymphoma (DLBCL).	20660832
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is a kind of clonal stem-cell disorder in which aberration within a hematopoietic stem cell (HSC) gives rise to the entire disease as in acute myeloid leukemia (AML).	20662087
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Studies have showed that contrasting normal stem cells, AML stem cells express CD96 and CD123, but lack of CD90, although both of them reside within the CD34(+)CD38(-) population.	20662087
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Taken together, we demonstrate MDS stem cells display deranged phenotypic abnormalities that may make them particularly difficult to eradicate using therapies targeted against surface antigens, and the percentage of cells expressing CD13 is notably higher in patients with high-grade MDS that may be a potential prognostic indicator of MDS in the future.	20662087
Hyperpigmentation, Stem Cell Factor	Stem Cell Exhaustion	To analyse the involvement of the fibroblast-derived growth factors, hepatocyte growth factor (HGF), keratinocyte growth factor (KGF) and stem cell factor (SCF) in SL hyperpigmentation; to evaluate whether the photoageing process occurring in fibroblasts could be responsible for the altered expression of these cytokines; and to investigate a new possible role of KGF in regulating pigmentation through the specific induction of melanogenic cytokines by keratinocytes.	20662835
Specialty Type - cancer, Malignant Glioma	Stem Cell Exhaustion	Irradiation of the potential cancer stem cell niches in the adult brain improves progression-free survival of patients with malignant glioma.	20663133
Glioblastoma Multiforme Pathway, Neoplasms	Stem Cell Exhaustion	Our study leads us to hypothesize that in glioma targeted radiotherapy of the stem cell niches in the adult brain could yield significant benefits over radiotherapy of the primary tumor mass alone and that damage caused by smaller fractions of radiation maybe less efficiently detected by the DNA repair mechanisms in CSCs.	20663133
Adult Glioblastoma, Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	The mechanisms leading to glioblastoma are not well understood but animal studies support that inactivation of tumor suppressor genes in neural stem cells (NSC) is required and sufficient to induce glial cancers.	20663133
Specialty Type - cancer	Stem Cell Exhaustion	This suggests that the NSC niches in the brain may harbor cancer stem cells (CSCs), Thus providing novel therapy targets.	20663133
Multiple Myeloma	Stem Cell Exhaustion	The aim of this study was to compare the long-term safety and efficacy of oral busulfan 12 mg/kg plus melphalan 140 mg/m(2) and melphalan 200 mg/m(2) as conditioning regimens for autologous stem cell transplantation in newly diagnosed patients with multiple myeloma in the GEM2000 study.	20663944
Hodgkin Disease, Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Pretransplantation [18-F]fluorodeoxyglucose positron emission tomography scan predicts outcome in patients with recurrent Hodgkin lymphoma or aggressive non-Hodgkin lymphoma undergoing reduced-intensity conditioning followed by allogeneic stem cell transplantation.	20665491
Hodgkin Disease, LIPC gene, Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	The use of positron emission tomography (PET) scanning in Hodgkin lymphoma (HL) and aggressive non-Hodgkin lymphoma (HG-NHL) has recognized prognostic value in patients who are receiving chemotherapy or undergoing autologous stem cell transplantation (SCT).	20665491
Best Case Imputation Technique, Triple-Negative Breast Cancer Finding	Stem Cell Exhaustion	The combination of increased parity and shorter breastfeeding duration might increase the odds of the least differentiated triple-negative breast cancer (BC) phenotype, theoretically because an expanded progenitor cell population from each pregnancy would incompletely differentiate postpartum.	20665494
dendritic lamellar body	Stem Cell Exhaustion	To evaluate changes in neural stem cells and progenitors in the hippocampal neurogenic niche, immunohistochemistry (IHC) using the neural stem cell markers Musashi 1, nestin, proliferating cell nuclear antigen (PCNA), doublecortin, and glial fibrillary acidic protein (GFAP) were examined in age-matched control and DLB groups.	20665591
Communicable Diseases	Stem Cell Exhaustion	Cytomegalovirus (HCMV) remains an important infection following stem cell transplantation (SCT) and is managed via pre-emptive therapy.	20667769
Pneumocystis jiroveci pneumonia, Bronchiolitis Obliterans Organizing Pneumonia	Stem Cell Exhaustion	Relapsing infiltrates after pneumocystis pneumonia in stem cell transplant patients: think about BOOP!	20669790
Bronchiolitis, Bronchiolitis Obliterans Organizing Pneumonia, Pneumonia	Stem Cell Exhaustion	Bronchiolitis Obliterans Organizing Pneumonia (BOOP) can complicate allogeneic haematopoietic stem cell transplantation.	20669790
Pneumocystis jiroveci pneumonia, Bronchiolitis Obliterans Organizing Pneumonia	Stem Cell Exhaustion	We report a fatal case of BOOP after tapering the corticosteroids that the patient received for a Pneumocystis jirovecii pneumonia after stem cell transplantation.	20669790
Infection, Childhood Non-Hodgkin Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Early infections in patients undergoing high-dose treatment with stem cell support: a comparison of patients with non-Hodgkin lymphoma and multiple myeloma.	20670481
Infection	Stem Cell Exhaustion	Infections are life-threatening complications in patients undergoing high-dose chemotherapy with stem cell support (HDT).	20670481
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Anemia, Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH) and myelodysplastic syndromes (MDS) are clonal disorder of haematopoietic stem cells that may eventually lead to chronic anemia.	20670483
Neoplasms	Stem Cell Exhaustion	Taken together, the above findings suggest that Notch3 pathway activation reprograms tumor cells to assume an array of embryonic stem cell markers and participates in development of chemoresistance in HGSC.	20671266
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Maintenance therapy with low-dose azacitidine after allogeneic hematopoietic stem cell transplantation for recurrent acute myelogenous leukemia or myelodysplastic syndrome: a dose and schedule finding study.	20672358
Calcinosis	Stem Cell Exhaustion	We propose that this stimulation of TNAP in VSMCs in vitro and in vivo may be sufficient to induce the calcification of collagen fibrils, and that the absence of crystal clearance, in turn, induces the differentiation of VSMCs and/or mesenchymal stem cells into bone-forming cells, eventually leading to formation of a bone-like tissue.	20674184
Malignant Neoplasms	Stem Cell Exhaustion	Intravenous busulfan plus melphalan is a highly effective, well-tolerated preparative regimen for autologous stem cell transplantation in patients with advanced lymphoid malignancies.	20674757
Malignant Neoplasms	Stem Cell Exhaustion	busulfan (Bu) combined with melphalan (Mel) in patients with advanced lymphoid malignancies undergoing autologous stem cell transplantation.	20674757
Aneuploidy	Stem Cell Exhaustion	Here we attempt to avoid aneuploidy and improve cell quality by expanding human cardiac stem cells in physiological low-oxygen (5% O(2)) conditions, rather than in traditional culture in a general CO(2) incubator (20% O(2)).	20675298
Malignant Neoplasms	Stem Cell Exhaustion	Further studies are required to determine whether management of malignancy, particularly stem-cell transplantation should be adapted to HEV status.	20678959
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	PTLD has been described in allogeneic hematopoietic stem cell transplant (HSCT) and rarely in autologous HSCT.	20680523
Therapy-related myelodysplastic syndrome, Acute leukemia	Stem Cell Exhaustion	Hematopoietic stem cell transplantation for therapy-related myelodysplastic syndrome and acute leukemia: a single-center analysis of 47 patients.	20680530
Cessation of life	Stem Cell Exhaustion	Early evidence linked age-associated reductions in the levels of circulating marrow-derived hematopoietic stem cells (HSC), characterized by expression of early HSC markers CD133 and CD34, with the occurrence of cardiovascular events and associated death.	20680811
Liver carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	The cancer stem cell marker CD133 is a predictor of the effectiveness of S1+ pegylated interferon a-2b therapy against advanced hepatocellular carcinoma.	20683621
Lymphoma, Non-Hodgkin, Toxic effect	Stem Cell Exhaustion	BEAM or BuCyE high-dose chemotherapy followed by autologous stem cell transplantation in non-Hodgkin's lymphoma patients: a single center comparative analysis of efficacy and toxicity.	20684990
Toxic effect, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	We compared the efficacy and toxicity of BEAM (BCNU, etoposide, cytarabine and melphalan) and BuCyE (busulfan, cyclophosphamide and etoposide), given prior to autologous stem cell transplantation (ASCT), in 65 patients with non-Hodgkin's lymphoma.	20684990
Bacteremia, Vancomycin-Resistant Enterococci	Stem Cell Exhaustion	The changing epidemiology of vancomycin-resistant Enterococcus (VRE) bacteremia in allogeneic hematopoietic stem cell transplant (HSCT) recipients.	20685257
Bacteremia, Vancomycin-Resistant Enterococci, Hemopoietic stem cell transplant	Stem Cell Exhaustion	The impact of the rising prevalence of vancomycin-resistant Enterococcus (VRE) prior to hematopoietic stem cell transplantation (HSCT) and changes in transplant techniques on risk of VREB (VRE bacteremia) early after HSCT is not known.	20685257
Myelitis	Stem Cell Exhaustion	Human herpes virus (HHV)6-associated limbic encephalitis and/or myelitis is one of the life-threatening central nervous system complications following allogeneic hematopoietic stem cell transplantation (HSCT).	20685258
Kidney Failure	Stem Cell Exhaustion	Patients 1 and 2 were not considered candidates for autologous peripheral blood stem cell transplantation (PBSCT) because of their nonresponse to the bortezomib-based regimens and severe deterioration of their clinical conditions (kidney and liver failure) due to disease progression.	20685499
Cryoglobulinemic glomerulonephritis, Waldenstrom Macroglobulinemia	Stem Cell Exhaustion	Successful treatment of cryoglobulinemic glomerulonephritis derived from Waldenstrom's macroglobulinemia by rituximab-CHOP and tandem high-dose chemotherapy with autologous peripheral blood stem cell transplantation.	20686877
Chronic disease	Stem Cell Exhaustion	It is reasonable to suspect that many undefined chronic diseases are caused by the malfunction of stem cells.	20691545
Chronic disease	Stem Cell Exhaustion	Chronic diseases are phenotypes of stem cells' malfunction.	20691545
Chronic disease	Stem Cell Exhaustion	In addition, stem cells accumulate mutations from fetus stage to aging period and usually develop chronic diseases in late life periods.	20691545
PDX1 gene	Stem Cell Exhaustion	We also tested whether growth factors and protein transduction of pancreatic and duodenal homeobox factor-1 (PDX-1) and BETA2/NeuroD into human pancreatic stem/progenitor cells induced insulin or pancreas-related gene expressions.	20692413
Coronary heart disease	Stem Cell Exhaustion	[Effect of soluble epoxide hydrolase inhibitor on the function of endothelial progenitor cells in patients with coronary heart disease].	20693709
Coronary heart disease, altretamine/cisplatin/cyclophosphamide protocol	Stem Cell Exhaustion	To investigate the effect of soluble epoxide hydrolase inhibitor (sEHi) tAUCB on the function of endothelial progenitor cells (EPCs) and expression of vascular endothelial growth factor (VEGF) in EPCs in patients with coronary heart disease (CHD).	20693709
Cytomegalovirus Infections, Allogeneic Hematopoietic Stem Cell Transplantation	Stem Cell Exhaustion	Use of foscarnet for cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation from a related donor.	20694532
Communicable Diseases	Stem Cell Exhaustion	Foscarnet is an active agent against cytomegalovirus (CMV) infection after hematopoietic stem cell transplantation (HSCT), as well as ganciclovir.	20694532
Adult Glioblastoma, Neoplasms	Stem Cell Exhaustion	Studies in glioblastoma demonstrated that ASPM gene was overexpressed when compared to normal brain and ASPM inhibition by siRNA-mediated inhibits tumor cell proliferation and neural stem cell proliferation, supporting ASPM gene as a potential molecular target in glioblastoma.	20694558
Neoplasms, Medulloblastoma	Stem Cell Exhaustion	ASPM overexpression may modify the ability of stem cells to differentiate during the development of the central nervous system, contributing to the development of medulloblastoma, a tumor of embryonic origin from cerebellar progenitor cells.	20694558
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Favorable outcomes of intravenous busulfan, fludarabine, and 400 cGy total body irradiation-based reduced-intensity conditioning allogeneic stem cell transplantation for acute myelogenous leukemia with old age and/or co-morbidities.	20694843
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	To define the role of RIC in AML with old age (>or=55 years) and/or co-morbidities (HCT-CI scores >or=2), we analyzed patients who received allogeneic stem cell transplantation (SCT) with Flu/Bu/TBI 400 cGy/+/-antithymocyte globulin (ATG) conditioning regimen.	20694843
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	High-dose melphalan with or without stem cell support before myeloablative allo-SCT for remission induction in patients with advanced relapsed or refractory AML.	20697364
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A total of 23 patients with relapsed/refractory AML were prospectively scheduled for HDM with or without stem cell support followed by myeloablative allogeneic HSCT.	20697364
Toxic effect, Gastrointestinal mucositis	Stem Cell Exhaustion	There were no differences between patients with or without immediate stem cell support regarding mucositis or other organ toxicity.	20697364
Pleural Effusion, CTCAE, Pulmonary Aspergillosis	Stem Cell Exhaustion	The patient was submitted to two cycles of chemotherapy, autologous stem cell transplantation, and intrathecal chemotherapy, but he died after 10 months because of disease complications (lung aspergillosis and pleural effusion).	20698152
Hematological Disease, leukemia	Stem Cell Exhaustion	Leukemia is a hematological disorder arises from a hematopoietic stem cell characterized by a disordered differentiation and proliferation of neoplastic cells.	20701007
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	The impact of HLA matching on long-term transplant outcome after allogeneic hematopoietic stem cell transplantation for CLL: a retrospective study from the EBMT registry.	20703257
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	We analyzed 368 chronic lymphocytic leukemia patients who underwent allogeneic hematopoietic stem cell transplantation reported to the EBMT registry between 1995 and 2007.	20703257
Neutropenia	Stem Cell Exhaustion	To reduce the duration of neutropenia after conditioning chemotherapy and autologous peripheral blood stem cell transplantation (APBSCT), granulocyte-colony stimulating factors (G-CSF) are commonly administered.	20706722
Hemopoietic stem cell transplant	Stem Cell Exhaustion	Novel H1N1 influenza in hematopoietic stem cell transplantation recipients: two centers' experiences.	20708084
Respiratory Tract Infections, Influenza, Hemopoietic stem cell transplant	Stem Cell Exhaustion	Respiratory virus infections, such as influenza A, cause significant morbidity in hematopoietic stem cell transplantation (HSCT) recipients.	20708084
Influenza due to Influenza A virus subtype H1N1, Hematologic Neoplasms	Stem Cell Exhaustion	Humoral and cellular immunity to primary H1N1 infection in patients with hematologic malignancies following stem cell transplantation.	20708085
Influenza due to Influenza A virus subtype H1N1, Multiple Myeloma, Myeloid Leukemia, Chronic, Chronic Lymphocytic Leukemia, Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Ninety-two patients presented with influenza-like symptoms, and 13 had H1N1 infection confirmed by RT-PCR, including 4 allogeneic stem cell transplant recipients (1 with acute myelogenous leukemia, 1 with chronic lymphoblastic leukemia [CLL], 1 with non-Hodgkin lymphoma, and 1 with chronic myelogenous leukemia), 5 patients with multiple myeloma following autologous stem cell transplantation, 1 patient with multiple myeloma perimobilization, 2 patients with NHL post chemotherapy, and 1 patient with CLL.	20708085
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	The stem cell gene "inhibitor of differentiation 1" (ID1) is frequently expressed in non-small cell lung cancer.	20709421
Lymphoma, Non-Hodgkin, Familial, B-Cell Lymphomas	Stem Cell Exhaustion	Salvage therapy for patients with refractory/relapsed B-cell non-Hodgkin lymphoma (NHL) is based on polychemotherapy, followed by high-dose therapy and autologous stem cell transplantation in eligible patients (HDT/ASCT).	20709662
Multiple Myeloma	Stem Cell Exhaustion	Improved survival for multiple myeloma in denmark based on autologous stem cell transplantation and novel drug therapy in collaborative trials: analysis of accrual, prognostic variables, selection bias, and clinical behavior on survival in more than 1200 patients in trials of the nordic myeloma study group.	20709667
Malignant tumor of colon	Stem Cell Exhaustion	Although CD133 has been reported to be a promising colon cancer stem cell marker, the biological functions of CD133+ colon cancer cells remain controversial.	20711432
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Human progenitor cells derived from cardiac adipose tissue ameliorate myocardial infarction in rodents.	20713059
Autoimmune Diseases	Stem Cell Exhaustion	Rheumatic autoimmune disorders are characterized by a sustained pro-inflammatory microenvironment associated with impaired function of endothelial progenitor cells (EPC) and concomitant vascular defects.	20716116
Acute lymphocytic leukemia	Stem Cell Exhaustion	Reduced-intensity versus conventional myeloablative conditioning allogeneic stem cell transplantation for patients with acute lymphoblastic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation.	20716774
Acute lymphocytic leukemia	Stem Cell Exhaustion	This retrospective study assessed the outcome of 576 adult acute lymphoblastic leukemia patients aged >= 45 years, and who received a reduced-intensity conditioning (RIC; n = 127) or myeloablative conditioning (MAC; n = 449) allogeneic stem cell transplantation (allo-SCT) from a human leukocyte antigen-identical sibling while in complete remission.	20716774
Thrombotic Microangiopathies	Stem Cell Exhaustion	Validation of recently proposed consensus criteria for thrombotic microangiopathy after allogeneic hematopoietic stem-cell transplantation.	20717073
Thrombomodulin Alfa	Stem Cell Exhaustion	To validate recently proposed criteria for TMA by CTN and IWG, we analyzed 672 patients who underwent allogeneic stem-cell transplantation between January 2002 and December 2006.	20717073
S100A4 protein, human	Stem Cell Exhaustion	PcG genes play an important role in developmental processes; they are also involved in the self-renewal of hematopoietic and neural stem cells as well as in malignant transformation.	20717685
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	The combination of stem cell markers CD133 and ABCG2 predicts relapse in stage I non-small cell lung carcinomas.	20717756
Non-Small Cell Lung Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	The aim of the study was to investigate the expression of two cancer stem cell markers CD133 and ATP-binding cassette superfamily G member 2 (ABCG2) in non-small cell lung carcinomas (NSCLC) and evaluate their prognostic values for postoperative relapse.	20717756
Lupus Nephritis	Stem Cell Exhaustion	Therapeutic effects of umbilical cord blood-derived mesenchymal stem cell transplantation in experimental lupus nephritis.	20719085
Endothelial dysfunction	Stem Cell Exhaustion	Circulating endothelial cells (CECs) and endothelial progenitor cells (EPCs) may serve as novel markers of endothelial dysfunction.	20720219
Autoimmune Diseases	Stem Cell Exhaustion	Differences in clearance of mycophenolic acid among renal transplant recipients, hematopoietic stem cell transplant recipients, and patients with autoimmune disease.	20720518
Autoimmune Diseases	Stem Cell Exhaustion	MMF is being used increasingly in hematopoietic stem cell transplantation (HSCTx) and autoimmune diseases (AID).	20720518
Hepatitis C, Hepatobiliary Disorder	Stem Cell Exhaustion	Hepatic progenitor cells in chronic hepatitis C: a phenomenon of older age and advanced liver disease.	20721577
Liver diseases	Stem Cell Exhaustion	Hepatic progenitor cells (HPC) appear in a variety of liver diseases.	20721577
Multiple Myeloma	Stem Cell Exhaustion	Depth of response assessed by quantitative ASO-PCR predicts the outcome after stem cell transplantation in multiple myeloma.	20722702
Multiple Myeloma	Stem Cell Exhaustion	We used a sensitive real-time quantitative polymerase chain reaction by allele-specific primers (qASO-PCR) to assess the level of minimal residual disease (MRD) in bone marrow of 37 patients with myeloma who had achieved CR/near-to-CR after autologous or allogeneic stem cell transplantation (SCT).	20722702
Hemorrhagic cystitis	Stem Cell Exhaustion	[Incidence and risk factors of hemorrhagic cystitis after hematopoietic stem cell transplantation].	20723318
CLTC gene, Hemorrhagic cystitis	Stem Cell Exhaustion	The aim of this study was to analyze the risk factors of hemorrhagic cystitis (HC) after hematopoietic stem cell transplantation (HSCT).	20723318
Systemic Scleroderma	Stem Cell Exhaustion	Mobilization of endothelial progenitor cells by intravenous cyclophosphamide in patients with systemic sclerosis.	20724431
Lung Diseases, Interstitial, Sample Size Calculation	Stem Cell Exhaustion	CYC on the number of circulating endothelial progenitor cells (EPCs) in patients with SSc, and the potential association of the EPC response with CYC's effect for treating interstitial lung disease (ILD).	20724431
Disseminated, Toxoplasmosis	Stem Cell Exhaustion	Acute disseminated fatal toxoplasmosis after haploidentical stem cell transplantation despite atovaquone prophylaxis in a young man.	20724953
Disseminated, Toxoplasmosis, Acute lymphocytic leukemia	Stem Cell Exhaustion	We describe a case of fatal acute disseminated breakthrough toxoplasmosis in a 19-year-old adolescent after haploidentical hematopoietic stem cell transplantation for acute lymphoblastic leukemia despite continued atovaquone prophylaxis.	20724953
Aggressive course	Stem Cell Exhaustion	A case of aggressive myeloma recognized shortly after the remission following high-dose chemotherapy with autologous peripheral blood stem cell transplantation.	20725814
Multiple Myeloma	Stem Cell Exhaustion	In August 2005, the patient was diagnosed with IgA-l type multiple myeloma with chromosome 13 deletion, and received three cycles of vinclistine, adriamycin and dexamethasone followed by high-dose melphalan-based autologous peripheral stem cell transplantation: this resulted in remission 2 months before admission to our hospital.	20725814
Colorectal Carcinoma, Cytogenetic Complete Response	Stem Cell Exhaustion	Here we asked whether different TLR, COX-2 and stem cell marker expression profiles in colorectal cancer (CRC) provide further evidence for this hypothesis from a clinical perspective.	20728343
Adult Glioblastoma	Stem Cell Exhaustion	Human glioblastoma tumours and neural cancer stem cells express the chemokine CX3CL1 and its receptor CX3CR1.	20728344
MS gene	Stem Cell Exhaustion	Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis.	20730303
MS gene	Stem Cell Exhaustion	To evaluate the impact of autologous hematopoetic stem cell transplantation (autoHSCT) in the health related quality of life (HRQL) in patients with multiple sclerosis.	20730303
Hodgkin Disease	Stem Cell Exhaustion	Pretransplantation functional imaging predicts outcome following autologous stem cell transplantation for relapsed and refractory Hodgkin lymphoma.	20733154
Heart failure, Amyloidosis	Stem Cell Exhaustion	Cardiac transplantation followed by dose-intensive melphalan and autologous stem-cell transplantation for light chain amyloidosis and heart failure.	20733534
Heart failure, Amyloidosis	Stem Cell Exhaustion	Autologous stem-cell transplantation (ASCT) has become a common therapy for AL amyloidosis, but there is an exceedingly high treatment-related mortality in patients with heart failure.	20733534
Adult Glioblastoma	Stem Cell Exhaustion	EGFR signaling is differentially activated in patient-derived glioblastoma stem cells.	20734923
Seizures, Hepatic Encephalopathy, Hypertension, CTCAE	Stem Cell Exhaustion	Prophylactic treatment for hypertension and seizure in a case of allogeneic hematopoietic stem cell transplantation after posterior reversible encephalopathy syndrome.	20735807
Neoplasms	Stem Cell Exhaustion	The molecular characterization of these potential stem cell populations could be critical to find new therapeutic targets and to develop an effective therapy for these tumours with very dismal prognosis.	20735813
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Recent studies have demonstrated the existence of a small fraction of glioma cells with characteristics of neural stem cells which are able to grow in vitro forming neurospheres and that can be isolated in vivo using surface markers such as CD133.	20735813
Inferior, Osteoporosis	Stem Cell Exhaustion	It has been previously shown that in patients with osteoporosis, mesenchymal stem cell (MSC) growth rate and osteogenic potential is decreased contributing to inferior fracture consolidation.	20736793
Osteoporotic Fractures	Stem Cell Exhaustion	The effect of bone morphogenetic protein-2, bone morphogenetic protein-7, parathyroid hormone, and platelet-derived growth factor on the proliferation and osteogenic differentiation of mesenchymal stem cells derived from osteoporotic bone.	20736793
Gammopathy	Stem Cell Exhaustion	Prospective evaluation of epstein-barr virus reactivation after stem cell transplantation: association with monoclonal gammopathy.	20737201
EBV-Related Clonal Post-Transplant Lymphoproliferative Disorder, Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Epstein-Barr Virus (EBV) reactivation and EBV-related post-transplant lymphoproliferative disease (PTLD) have emerged as a severe complication after stem cell transplantation (SCT).	20737201
Cessation of life, Bacterial Infections	Stem Cell Exhaustion	Although bacterial infection is a major cause of death even after reduced-intensity conditioning (RIC) for allogeneic stem cell transplantation (SCT), little is known about the epidemiology and risk factors.	20738830
Aspergillosis	Stem Cell Exhaustion	Catheter-associated aspergillosis of the chest wall following allogeneic hematopoietic stem cell transplantation.	20738831
Herbaspirillum, Acute lymphocytic leukemia	Stem Cell Exhaustion	We report Herbaspirillum bacteremia in a 2-year-old female patient following a hematopoietic stem cell transplant for relapsed acute lymphoblastic leukemia.	20739483
Metabolic Diseases	Stem Cell Exhaustion	Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells.	20739751
Malignant Neoplasms, Chronic Obstructive Asthma, Osteoporosis, Fibrosis, Liver, Atherosclerosis, Periodontitis, Liver Cirrhosis, Lung diseases, Degenerative disorder, Nephrosclerosis	Stem Cell Exhaustion	A parallel literature describes an elevated list of chronic degenerative disease as common in such patients including neurodegenerative conditions, atherosclerosis, nephrosclerosis, hepatic fibrosis and cirrhosis, chronic obstructive and fibrotic lung disease, osteoporosis, chronic periodontitis, various cancers, hair greying, and stem cell suppression.	20800362
Mucopolysaccharidoses	Stem Cell Exhaustion	Maroteaux-Lamy syndrome (mucopolysaccharidosis type VI): a single dose of galsulfase further reduces urine glycosaminoglycans after hematopoietic stem cell transplantation.	20800524
Ultrastructural Pathology, Cervical cord compression	Stem Cell Exhaustion	Patients fully engrafted after hematopoietic stem cell transplantation (HSCT) demonstrate several indicators of metabolic correction such as reduction in liver size, absence of hepatic ultrastructural pathology, and patients do not develop cervical cord compression.	20800524
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Reduced stem cell mobilization with advancing age could explain, in part, the observation that age is associated with poor prognosis in patients with myocardial infarction.	20800644
Coronary Arteriosclerosis	Stem Cell Exhaustion	Evidence of mobilization of pluripotent stem cells into peripheral blood of patients with myocardial ischemia.	20800644
Inflammation	Stem Cell Exhaustion	To elucidate the mechanistic link between inflammation and stem cell mobilization after coronary stenting.	20800911
Restenosis, Vascular System Injuries	Stem Cell Exhaustion	After stent-related vascular injury, an inflammatory response triggers the mobilization of bone marrow-derived stem cells, including both endothelial and smooth muscle progenitors, leading to re-endothelialization as well as restenosis.	20800911
Thrombocytosis, Myeloproliferative disease, Primary Myelofibrosis, Polycythemia Vera, Fibrosis Assessment, PMF Regimen	Stem Cell Exhaustion	We have studied TGFb1 levels in Philadelphia-negative (Ph-) myeloproliferative diseases, evaluating patients with primary myelofibrosis (PMF) that is characterized by increased numbers of circulating progenitor cells and bone marrow (BM) fibrosis, and patients with polycythemia vera (PV) or essential thrombocythemia (ET) that do not present BM fibrosis.	20801055
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukaemia (AML) is a heterogeneous clonal disorder of haematopoietic progenitor cells.	20803351
Neoplasms	Stem Cell Exhaustion	We have previously developed a polychromatic flow cytometry (PFC) protocol to isolate subsets of hematopoietic cells and we now identify the circulating pool of CD34(+)CD45(dim) cells representing functional circulating hematopoietic stem and progenitor cells (CHSPCs) that can be separated on the basis of AC133 expression and report that the AC133(+) subset of the CHSPCs enhances the growth of tumor blood vessels in vivo in immunodeficient mice.	20803735
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Three months after stem cell transplantation, central nervous system myelomatosis progressed to plasma cell leukemia and two months later, the patient expired.	20805703
Adult Glioblastoma	Stem Cell Exhaustion	Expression of the stem cell marker CD133 in recurrent glioblastoma and its value for prognosis.	20806346
Adult Glioblastoma, Aggressive behavior	Stem Cell Exhaustion	Experimental data suggest that glioblastoma cells expressing the stem cell marker CD133 play a major role in radiochemoresistance and tumor aggressiveness.	20806346
Adult Glioblastoma, Specialty Type - cancer	Stem Cell Exhaustion	An analysis of tumor-specific chromosomal aberrations and in vivo studies revealed that the CD133-positive cell compartment of recurrent glioblastoma was composed of both cancer stem cells and nontumor neural stem cells.	20806346
Adult Glioblastoma, Neoplasms	Stem Cell Exhaustion	The authors hypothesized that, similar to the phenomenon described in glioblastoma models, neural stem/progenitor cells that are recruited by the tumor from surrounding brain may exert an antitumorigenic effect.	20806346
Aspergillosis	Stem Cell Exhaustion	In this study, the recently characterized human DECTIN1 Y238X early stop codon polymorphism leading to diminished Dectin-1 receptor activity was studied in relation to invasive aspergillosis susceptibility and severity in patients receiving hematopoietic stem cell transplantation.	20807886
Aspergillosis	Stem Cell Exhaustion	We found that the presence of the DECTIN1 Y238X polymorphism in either donors or recipients of hematopoietic stem cell transplantation increased susceptibility to aspergillosis, with the risk being highest when the polymorphism was present simultaneously in both donors and recipients (adjusted hazard ratio = 3.9; P = .005).	20807886
Glomerulonephritis, Membranoproliferative	Stem Cell Exhaustion	Membranoproliferative glomerulonephritis following allogeneic hematopoietic stem cell transplantation.	20809109
Graft-vs-Host Disease, Nephrotic Syndrome, Glomerulonephritis, Membranoproliferative, Chronic graft-versus-host disease	Stem Cell Exhaustion	Nephrotic syndrome after allogeneic hematopoietic stem cell transplantation has been increasingly described as a manifestation of chronic graft-versus-host disease (GVHD); however, GVHD-associated membranoproliferative glomerulonephritis is extremely rare.	20809109
Myelitis	Stem Cell Exhaustion	Recurrent myelitis after allogeneic stem cell transplantation.	20809972
Hematologic Neoplasms, Autoimmune Diseases	Stem Cell Exhaustion	Allogeneic and autologous haematopoietic stem cell transplantation are established treatment options for haematological malignancies and may possibly be employed to treat a range of genetic and autoimmune diseases.	20809972
Myelitis	Stem Cell Exhaustion	We report two patients who developed an acute myelitis within their thoracic spinal cord after allogeneic stem cell transplantation.	20809972
Myelitis	Stem Cell Exhaustion	Myelitis is a possibly disabling consequence of haematopoietic stem cell transplantation.	20809972
Amyotrophic Lateral Sclerosis, Antilymphocyte Serum	Stem Cell Exhaustion	Functional neural stem cell isolation from brains of adult mutant SOD1 (SOD1(G93A)) transgenic amyotrophic lateral sclerosis (ALS) mice.	20810028
Amyotrophic Lateral Sclerosis, Antilymphocyte Serum	Stem Cell Exhaustion	The aim of present study is to investigate more functional neural stem cells (NSCs) could be isolated from brains with amyotrophic lateral sclerosis (ALS) and expanded in vitro, based on previous reports demonstrating de novo neurogenesis is enhanced to replace degenerating neural tissue.	20810028
Coronary Arteriosclerosis	Stem Cell Exhaustion	Organic nitrates differentially modulate circulating endothelial progenitor cells and endothelial function in patients with symptomatic coronary artery disease.	20812862
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	We hypothesised that autoantibodies detected in PNH patients could identify antigens that might play a role in the pathophysiology of this disease and screened a human fetal liver cDNA library for serological reactivity against haematopoietic stem/progenitor cells antigens using the SEREX approach.	20813002
Osteomyelitis	Stem Cell Exhaustion	Descriptive and statistical evaluations were conducted to investigate the influence of chemotherapy, corticosteroids, stem cell transplantation, and bisphosphonates on the development and clinical picture of osteomyelitis.	20817480
Agrobacterium tumefaciens	Stem Cell Exhaustion	Asymptomatic catheter related Rhizobium radiobacter infection in a haploidentical hemapoetic stem cell recipient.	20818107
Adenocarcinoma of lung (disorder)	Stem Cell Exhaustion	The expression of stem cell-related indicators as a prognostic factor in human lung adenocarcinoma.	20818602
Adenocarcinoma of lung (disorder)	Stem Cell Exhaustion	The purpose of the present study was to detect the presence of BASC-like stem cell-related indicators, such as clara cell secretory protein (CCSP), Octamer-4 (OCT4) and Bmi-1, and evaluate their implications in the prognosis of patients with lung adenocarcinoma.	20818602
Spinal Cord Injuries	Stem Cell Exhaustion	Combined NgR vaccination and neural stem cell transplantation promote functional recovery after spinal cord injury in adult rats.	20819171
serine-pyruvate transaminase activity, Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	SPT is a tumor of low-grade malignancy and may be derived from multipotent stem cells.	20819487
Neoplasms, Leukemia, Myelocytic, Acute, leukemia	Stem Cell Exhaustion	Recent studies have shown that interleukin-3 receptor alpha (CD123) is highly expressed on leukemia stem cells of patients with acute myeloid leukemia, and is correlated with tumor load and poor prognosis.	20819538
Infarction	Stem Cell Exhaustion	Mobilization of stem cells by G-CSF after reperfusion of infarct myocardium is safe and seems to offer a pragmatic strategy for recovery of myocardial global function.	20819563
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Persistent malignant stem cells in del(5q) myelodysplasia in remission.	20825315
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	To determine whether the persistence of rare but distinct malignant stem cells accounts for such relapses, we examined bone marrow specimens obtained from seven patients with the del(5q) myelodysplastic syndrome who became transfusion-independent while receiving lenalidomide treatment and entered cytogenetic remission.	20825315
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	In these patients with the del(5q) myelodysplastic syndrome, we identified rare and phenotypically distinct del(5q) myelodysplastic syndrome stem cells that were also selectively resistant to therapeutic targeting at the time of complete clinical and cytogenetic remission.	20825315
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Results of a phase 1, randomized, double-blind, placebo-controlled trial of bone marrow mononuclear stem cell administration in patients following ST-elevation myocardial infarction.	20826249
Kidney Failure, Acute	Stem Cell Exhaustion	This was confirmed in a blinded validation set of 20 patients in the intensive care unit and 31 allogeneic hematopoietic stem cell transplantation patients, of which 13 had and 18 had not experienced an episode of AKI.	20827258
Chronic graft-versus-host disease	Stem Cell Exhaustion	The graft-versus-leukemia effect is mainly restricted to NIH-defined chronic graft-versus-host disease after reduced intensity conditioning before allogeneic stem cell transplantation.	20827288
Chronic myocardial ischemia	Stem Cell Exhaustion	Stem cell therapy has been combined in most cases with coronary artery bypass grafting (CABG) for chronic ischemic heart disease.	20829387
Mitral Valve Insufficiency	Stem Cell Exhaustion	Here, we report the first case of a patient with ischemic mitral regurgitation treated by videoscopic, transvalvular, intramyocardial bone marrow stem cell injection, while undergoing minimally-invasive mitral valve repair.	20829387
Maxillary Sinus	Stem Cell Exhaustion	Maxillary sinus floor elevation with bovine bone mineral combined with either autogenous bone or autogenous stem cells: a prospective randomized clinical trial.	20831758
bone marrow fibrosis	Stem Cell Exhaustion	The impact of bone marrow fibrosis on the outcome of hematopoietic stem cell transplantation.	20832575
bone marrow fibrosis	Stem Cell Exhaustion	We retrospectively analyzed the data of 175 patients who underwent autologous (n = 69) or allogeneic hematopoietic stem cell transplantation (HCT) (n = 106) including 19 (27.5%) and 38 (35.8%) recipients who had bone marrow fibrosis (BMF) prior to transplantation, respectively.	20832575
Graft-vs-Host Disease	Stem Cell Exhaustion	Tacrolimus is commonly used in stem cell transplant recipients for prophylaxis of graft-vs-host disease.	20832577
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic haematopoietic stem cell transplantation represents a potential life-saving procedure for many patients affected by acute myeloid leukaemia.	20837331
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A multicentric, prospective intention-to-treat study is warranted in order to define which haematopoietic stem cell source represents the best choice for allogeneic transplant in high-risk acute myeloid leukaemia.	20837331
Ischemia	Stem Cell Exhaustion	Waon therapy mobilized circulating endothelial progenitor cells and improved limb ischemia in patients with PAD.	20843662
Trichoepithelioma, Experimental Organism Basal Cell Carcinoma	Stem Cell Exhaustion	PHLDA1 (TDAG51) is a follicular stem cell marker and differentiates between morphoeic basal cell carcinoma and desmoplastic trichoepithelioma.	20846311
Trichoepithelioma	Stem Cell Exhaustion	Given the differentiation of trichoepithelioma along the follicular lineage and the proposed role of PHLDA1 as a follicular stem cell marker, we examined the staining pattern of PHLDA1 in the desmoplastic variant of trichoepithelioma and in its differential diagnostic conundrum, morphoeic BCC.	20846311
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic graft-versus-host disease (cGvHD) is a major concomitant phenomenon in recipients of allogeneic hematopoietic stem cell transplantations, affecting multiple organ systems including the eye.	20847653
Graft-vs-Host Disease, Dry Eye Syndromes	Stem Cell Exhaustion	To evaluate the efficacy of topical cyclosporine-A 0.05% (CsA) in the treatment of dry eye syndrome in ocular graft-versus-host disease after bone marrow transplantation (BMT) of hematopoietic stem cells.	20847658
Infection	Stem Cell Exhaustion	PCR diagnostics and monitoring of adenoviral infections in hematopoietic stem cell transplantation recipients.	20848295
Opportunistic Infections	Stem Cell Exhaustion	After stem cell transplantation, human patients are prone to life-threatening opportunistic infections with a plethora of microorganisms.	20848295
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Considering the high relapse rates of AML after allogeneic hematopoietic stem cell transplant, research aims to improve post-transplant surveillance.	20849383
Acute myeloid leukemia with mutated NPM1	Stem Cell Exhaustion	To determine the value of peripheral blood (PB) for post-transplant minimal residual disease monitoring, we compared 38 PB and bone marrow (BM) sample pairs in 25 stem cell recipients with NPM1-mutated AML (12 males, 13 females, ages 21-73 years).	20849383
Angina Pectoris, Coronary Arteriosclerosis	Stem Cell Exhaustion	To evaluate the midterm results of patients with angina and diffuse coronary artery disease treated with transmyocardial revascularization in combination with autologous stem cell therapy.	20849586
Coronary Arteriosclerosis	Stem Cell Exhaustion	Nineteen patients with diffuse coronary artery disease and medically refractory class III/IV angina were evaluated between June 2007 and December 2009 for sole therapy TMR combined with intramyocardial injection of concentrated stem cells.	20849586
Hematologic Neoplasms	Stem Cell Exhaustion	The development of reduced-intensity conditioning regimens rather than myeloablative regimens for allogeneic stem cell transplantation has led to decreased treatment-related mortality and increased use of this treatment modality, especially in older patients with hematological malignancies.	20850502
Hematologic Neoplasms	Stem Cell Exhaustion	In an attempt to address this limitation, we analyzed a single-center cohort of 100 consecutive patients with hematological malignancies undergoing allogeneic stem cell transplantation from a human leukocyte antigen-matched related donor with median follow-up of 60 months.	20850502
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Chimerism studies with quantitative real-time PCR in stem cell recipients with acute myeloid leukemia.	20851159
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Chimerism is well-established for surveillance of acute myeloid leukemia (AML) patients after allogeneic hematopoietic stem cell transplantation (HSCT), but interpretation of the results and techniques is not standardized.	20851159
Viral Encephalitis	Stem Cell Exhaustion	Viral encephalitis after allogeneic stem cell transplantation: a rare complication with distinct characteristics of different causative agents.	20851868
Viral Encephalitis	Stem Cell Exhaustion	Limited data are available on characteristics of viral encephalitis in patients after allogeneic stem cell transplantation.	20851868
Viral Encephalitis	Stem Cell Exhaustion	We analyzed 2,628 patients after allogeneic stem cell transplantation to identify risk factors and characteristics of viral encephalitis.	20851868
Encephalitis, Leukoencephalopathy	Stem Cell Exhaustion	The median onset time was 106 days after allogeneic stem cell transplantation for the total group of 32 patients, but onset times were shortest in those with human herpesvirus-6 encephalitis and longest in those with JC virus-associated progressive multifocal leukoencephalopathy.	20851868
Viral Encephalitis	Stem Cell Exhaustion	The use of OKT-3 or alemtuzumab for in vivo T-cell depletion is associated with an increased risk of viral encephalitis after allogeneic stem cell transplantation.	20851868
Stem Cell Factor	Stem Cell Exhaustion	Among the cytokine combinations tested for the CD34(+) fraction, a combination (SFIb) consisting of stem cell factor (SCF), FMS-like tyrosine kinase 3 ligand, interleukin-3, and basic fibroblast growth factor resulted in a reproducible 64- to 1468-fold EPC expansion from various cord blood origins.	20852063
Myocardial Ischemia	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) have been shown to have therapeutic potential in ischemic disease.	20852063
Nephritis, Tubulointerstitial	Stem Cell Exhaustion	Stem cell marker TRA-1-60 is expressed in foetal and adult kidney and upregulated in tubulo-interstitial disease.	20853169
Gastrointestinal mucositis	Stem Cell Exhaustion	Palifermin reduces mucositis when given in multiple doses to patients undergoing hematopoietic stem-cell transplantation.	20855800
Mandibulofacial Dysostosis	Stem Cell Exhaustion	This is a report of a 14-year-old adolescent boy with Treacher Collins syndrome whose bilateral orbitozygomatic defects were treated with engineered bone made from a combination of human bone allograft, adipose-derived mesenchymal stem cells, bone morphogenic protein-2, and periosteal grafts.	20856057
Hodgkin Disease	Stem Cell Exhaustion	Quality of life of long-term survivors with Hodgkin lymphoma after high-dose chemotherapy, autologous stem cell transplantation, and conventional chemotherapy.	20858092
Hodgkin Disease	Stem Cell Exhaustion	In this study, we investigated the quality of life (QoL) of long-term survivors with Hodgkin lymphoma who received high-dose chemotherapy (HDCT) followed by peripheral blood stem cell transplantation (PBSCT).	20858092
Graft-vs-Host Disease	Stem Cell Exhaustion	Defects in central and peripheral tolerance are thought to contribute to life-threatening graft-versus-host disease (GvHD), a severe complication following allogeneic stem cell transplantation (SCT).	20859740
Multiple Myeloma	Stem Cell Exhaustion	Lower alimentary tract mucositis was evaluated among 303 consecutive patients with myeloma (2004-2007) enrolled in a clinical trial consisting of induction chemotherapy, tandem melphalan-based autologous stem cell transplantation (ASCT), and consolidation.	20862749
Influenza vaccination, Multiple Myeloma	Stem Cell Exhaustion	Transfer of influenza vaccine-primed costimulated autologous T cells after stem cell transplantation for multiple myeloma leads to reconstitution of influenza immunity: results of a randomized clinical trial.	20864577
Multiple Myeloma, Morbidity - disease rate, Immunologic Deficiency Syndromes	Stem Cell Exhaustion	Severe immune deficiency follows autologous stem cell transplantation for multiple myeloma and is associated with significant infectious morbidity.	20864577
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Gene expression profiling of myelodysplastic CD34+ hematopoietic stem cells treated in vitro with decitabine.	20869114
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	We analyzed the gene expression profile of myelodysplastic and normal CD34+ hematopoietic stem cells (HSCs) treated in vitro with decitabine.	20869114
Engraftment syndrome	Stem Cell Exhaustion	Syngeneic donor hematopoietic stem cell transplantation is associated with high rates of engraftment syndrome.	20870027
Exanthema, Engraftment syndrome, Non-cardiogenic pulmonary edema	Stem Cell Exhaustion	Engraftment syndrome (ES), typically characterized by noninfectious fever, rash, and/or noncardiogenic pulmonary edema, is a complication of autologous and allogeneic hematopoietic stem cell transplantation (HSCT).	20870027
Malignant Neoplasms, TP53 gene, Neoplasms, Central neuroblastoma	Stem Cell Exhaustion	Inactivation of the p53 tumor suppressor pathway allows cell survival in times of stress and occurs in many human cancers; however, normal embryonic stem cells and some cancers such as neuroblastoma maintain wild-type human TP53 and mouse Trp53 (referred to collectively as p53 herein).	20871609
Neuroblastoma, Central neuroblastoma	Stem Cell Exhaustion	miR-380-5p is highly expressed in mouse embryonic stem cells and neuroblastomas, and high expression correlates with poor outcome in neuroblastomas with neuroblastoma derived v-myc myelocytomatosis viral-related oncogene (MYCN) amplification.	20871609
Specialty Type - cancer, Central neuroblastoma	Stem Cell Exhaustion	We demonstrate a new mechanism of p53 regulation in cancer and stem cells and uncover a potential therapeutic target for neuroblastoma.	20871609
Acute myocardial infarction	Stem Cell Exhaustion	Level and value of circulating endothelial progenitor cells in patients with acute myocardial infarction undergoing primary coronary angioplasty: in vivo and in vitro studies.	20875902
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Levels of circulating endothelial progenitor cells (EPCs) in acute ST-elevation myocardial infarction (STEMI) patients undergoing primary coronary intervention (PCI) were investigated in this study.	20875902
Peripheral Stem Cell Transplantation, Hematological Disease	Stem Cell Exhaustion	This phase 1/2 study assessed the augmentation of reduced-intensity conditioning (RIC) with total marrow and lymph node irradiation (TMLI), for peripheral blood stem cell transplantation, in patients with advanced hematologic disease.	20876852
Colorectal Carcinoma	Stem Cell Exhaustion	Frequency and pattern of expression of the stem cell marker CD133 have strong prognostic effect on the surgical outcome of colorectal cancer patients.	20878111
Colorectal Carcinoma, Specialty Type - cancer, Cytogenetic Complete Response	Stem Cell Exhaustion	CD133 has been reported to be a cancer stem cell marker in colorectal cancer (CRC).	20878111
Comorbidity	Stem Cell Exhaustion	Isolation of ASCs from 53 patients (50-89 years) revealed that advanced age or comorbidity did not negatively impact stem cell harvest; rather, higher numbers were observed in older donors (>70 years) than in younger.	20879833
Cardiovascular Diseases	Stem Cell Exhaustion	Endothelial differentiation of adipose-derived stem cells from elderly patients with cardiovascular disease.	20879833
Comorbidity	Stem Cell Exhaustion	These results suggest that (1) advanced age and comorbidity do not negatively impact isolation of ASCs, and (2) these stem cells retain significant capacity to acquire key endothelial cell traits throughout life.	20879833
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Plerixafor and granulocyte-colony-stimulating factor (G-CSF) in patients with lymphoma and multiple myeloma previously failing mobilization with G-CSF with or without chemotherapy for autologous hematopoietic stem cell mobilization: the Austrian experience on a named patient program.	20880037
Hodgkin Disease, Lymphoma, Non-Hodgkin, Multiple Myeloma	Stem Cell Exhaustion	Plerixafor in combination with granulocyte-colony-stimulating factor (G-CSF) has been shown to enhance stem cell mobilization in patients with multiple myeloma, non-Hodgkin's lymphoma, and Hodgkin's disease who demonstrated with previous mobilization failure.	20880037
Disease	Stem Cell Exhaustion	Although this disorder is curable by way of allogeneic stem cell transplantation, advanced age, limited donor availability, and multiple comorbidities often exclude patients from curative treatment.	20880813
Nephroblastoma	Stem Cell Exhaustion	Second high-dose chemotherapy intensification followed by hematopoietic stem cell transplantation applying a novel high-dose topotecan-based regimen in an adult Wilms' tumor patient: case report.	20881835
Nephroblastoma	Stem Cell Exhaustion	High-dose chemotherapy and hematopoietic stem cell support remains a valuable treatment option for the rare patient population with relapsed Wilms' tumor.	20881835
Acute lymphocytic leukemia	Stem Cell Exhaustion	Late recurrence of precursor B-cell acute lymphoblastic leukemia 9 years and 7 months after allogeneic hematopoietic stem cell transplantation.	20881873
Acute lymphocytic leukemia	Stem Cell Exhaustion	We present the case of a 15-year-old adolescent boy with recurrent precursor B-cell acute lymphoblastic leukemia, which appeared 9 years and 7 months after a first unrelated allogeneic hematopoietic stem cell transplantation (HSCT).	20881873
melanoma	Stem Cell Exhaustion	Expression of the stem cell markers nestin and CD133 on circulating melanoma cells.	20882037
NES gene	Stem Cell Exhaustion	These findings show that CMCs expressed stem cell-associated markers NES and CD133.	20882037
Graft-vs-Host Disease	Stem Cell Exhaustion	Antithymocyte globulins and chronic graft-vs-host disease after myeloablative allogeneic stem cell transplantation from HLA-matched unrelated donors: a report from the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire.	20882046
Graft-vs-Host Disease	Stem Cell Exhaustion	This retrospective report assessed the impact of rabbit antithymocyte globulins (ATG), incorporated within a standard myeloablative conditioning regimen prior to allogeneic stem cell transplantation (allo-SCT) using human leukocyte antigen-matched unrelated donors (HLA-MUD), on the incidence of acute and chronic graft-vs-host disease (GVHD).	20882046
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	We analyzed long-term outcomes of myeloablative stem cell transplantation (SCT) in 292 adults with Philadelphia (Ph)-negative acute lymphoblastic leukemia (ALL).	20882049
Cerebral artery occlusion, Infarction	Stem Cell Exhaustion	We reported previously that transplantation of human embryonic stem cell (hESC)-derived NPCs together with biomaterial (Matrigel) scaffolding into the brains of young adult Sprague-Dawley rats 3 weeks after distal middle cerebral artery occlusion (MCAO) reduced infarct volume and improved neurobehavioral performance.	20883527
Multiple Myeloma	Stem Cell Exhaustion	The emergence of oligoclonal bands is associated with a favorable outcome after autologous stem cell transplantation in multiple myeloma.	20884709
Type II Mucolipidosis, Osteosclerosis, Primary Myelofibrosis, Pancytopenia	Stem Cell Exhaustion	Agnogenic myeloid metaplasia (AMM) is a clonal stem cell disease, which is characterized by myelofibrosis, osteosclerosis and pancytopenia.	20886427
Hypersensitivity, Lymphoma, leukemia	Stem Cell Exhaustion	Lymphomatoid hypersensitivity reaction to levofloxacin during autologous stem cell transplantation: a potential diagnostic pitfall in patients treated for lymphoma or leukemia.	20887372
Mantle cell lymphoma	Stem Cell Exhaustion	We report a 61-year-old female who developed a purpuric eruption prior to engraftment of an autologous hematopoietic stem cell transplant for stage IV mantle cell lymphoma.	20887372
Lymphoma, Leukemia, Myelocytic, Acute, leukemia	Stem Cell Exhaustion	The histopathologic features presented in this paper underscore the potential for misdiagnosis of such lesions as lymphoma or acute myeloid leukemia, particularly in the setting of hematopoietic stem cell transplantation for underlying lymphoma or leukemia.	20887372
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	B1a cells identified during routine follow-up by immunophenotypic analysis in a middle-aged man who had a haploidentical stem cell transplant for acute myeloid leukemia were compared with a reference set of post-transplant samples.	20890952
melanoma, Childhood Breast Carcinoma, Adenocarcinoma of colon	Stem Cell Exhaustion	We first show that scoring captures differential induction of damage or inflammatory pathways in a series of public datasets involving radiotherapy of colon adenocarcinoma, chemotherapy of breast cancer cells, replicative senescence of mesenchymal stem cells, and progression of melanoma.	20920304
monoblast, Decreased platelet count, Leukocytosis	Stem Cell Exhaustion	On multivariate analysis, severe thrombocytopenia, leukocytosis, increasing marrow blast percentage, unfavorable cytogenetics, and salvage not including allogeneic stem cell transplantation were associated with a worse survival.	20923968
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Extensive analysis of the T315I substitution and detection of additional ABL mutations in progenitors and primitive stem cell compartment in a patient with tyrosine kinase inhibitor-resistant chronic myeloid leukemia.	20929330
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The aim of this study was to evaluate the behavior of T315I mutated cells and to study the presence of potential additional mutations in progenitors and stem cells from a patient with CML.	20929330
T-Cell Lymphoma	Stem Cell Exhaustion	Successful treatment of refractory enteropathy-associated T-cell lymphoma using high-dose chemotherapy and autologous stem cell transplantation.	20930447
Acute biphenotypic leukemia	Stem Cell Exhaustion	His past medical history revealed acute biphenotypic leukaemia with complete remission after allogeneic hematopoietic stem cell transplantation (unrelated donor).	20932445
Multiple Myeloma, Chemotherapy-induced Nausea and Vomiting Questionnaire	Stem Cell Exhaustion	Three palonosetron regimens to prevent CINV in myeloma patients receiving multiple-day high-dose melphalan and hematopoietic stem cell transplantation.	20935058
Morular Metaplasia of the Endometrium, Multiple Myeloma, Vomiting	Stem Cell Exhaustion	Explore safety and efficacy of three palonosetron-containing regimens for emesis prevention over 7 days in multiple myeloma (MM) patients receiving melphalan (100 mg/m(2)) and hematopoietic stem cell transplantation (HSCT).	20935058
Rheumatoid Arthritis, Chronic Fatigue Syndrome, HIV Infections	Stem Cell Exhaustion	Participants were recruited from the following 5 groups of patients: chronic fatigue syndrome (n = 32), human immunodeficiency virus infection (n = 43), rheumatoid arthritis (n = 97), hematopoietic stem-cell or solid organ transplant (n = 26), or a general cohort of patients presenting for medical care (n = 95).	20936980
Diffuse alveolar hemorrhage	Stem Cell Exhaustion	Serum cytokine profiles at the onset of severe, diffuse alveolar hemorrhage complicating allogeneic hematopoietic stem cell transplantation, treated successfully with pulse intravenous cyclophosphamide.	20938173
Hodgkin Disease, Lymphoma, Non-Hodgkin, Multiple Myeloma	Stem Cell Exhaustion	We analyzed retrospectively data regarding stem cell mobilization with plerixafor in a cohort of 61 patients suffering from multiple myeloma (N = 23), non-Hodgkin's lymphoma (N = 20), or Hodgkin's lymphoma (N = 18).	20938660
Failure, Pterygium	Stem Cell Exhaustion	However, there is a controversy in the pathogenesis of primary pterygium between limbal stem cell failure versus proliferation.	20938674
Multiple Myeloma	Stem Cell Exhaustion	A phase II open-label trial of bortezomib in patients with multiple myeloma who have undergone an autologous peripheral blood stem cell transplant and failed to achieve a complete response.	20938715
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	A majority of multiple myeloma (MM) patients fail to achieve complete response (CR) to peripheral blood stem cell transplantation (PBSCT); effective options following autologous transplantation are needed.	20938715
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Importantly, apoptosis was most pronounced in CD34+38- AML stem cells and all phase 2 patients showing apoptosis induction in CD34+38- cells achieved response.	20938744
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We conclude that at 350 mg/m2, AEG35156 is effective in knocking down XIAP in circulating blasts accompanied by the preferential induction of apoptosis in CD34+38- AML stem cells.	20938744
Neoplasms, Germ Cells	Stem Cell Exhaustion	This methodology is of importance in light of the evidence that cellular senescence is not only a biological process that is fundamental for organismal aging but also impedes formation of induced-pluripotent stem cells providing the barrier for neoplastic transformation and is the major mechanism of induction of reproductive cell death during treatment of solid tumors.	20939035
Graft-vs-Host Disease	Stem Cell Exhaustion	In vivo T-cell depletion with anti-thymocyte globulin is a commonly used strategy for the prevention of graft-versus-host disease (GVHD) and to avoid rejection after hematopoietic stem cell transplantation (HSCT).	20942840
Malignant neoplasm of kidney	Stem Cell Exhaustion	Increased haematopoietic progenitor cells are associated with poor outcome in patients with metastatic renal cancer treated with sunitinib.	20943595
Renal Cell Carcinoma	Stem Cell Exhaustion	Haematopoietic progenitor cells (HPCs) are present in blood in metastatic renal cell cancer (mRCC).	20943595
Acute Promyelocytic Leukemia	Stem Cell Exhaustion	Autologous stem cell transplantation for patients with acute promyelocytic leukemia in second molecular remission.	20944181
Aplastic Anemia, Mycoses	Stem Cell Exhaustion	Successful treatment of disseminated mixed invasive fungal infection after hematopoietic stem cell transplantation for severe aplastic anemia.	20946236
Asymptomatic Diseases, Multiple Myeloma	Stem Cell Exhaustion	Despite new medical products introduced in multiple myeloma therapy, autologous stem cell transplant (ASCT) remains a standard procedure in younger patients with symptomatic disease.	20946721
Multiple Myeloma	Stem Cell Exhaustion	Retrospective analysis of the results of high-dose chemotherapy with the support of autologous blood stem cells in patients with multiple myeloma.	20946721
Specialty Type - cancer, Precursor T cell lymphoblastic leukemia/lymphoblastic lymphoma	Stem Cell Exhaustion	Parents of children with cancer receiving intensive chemotherapy for leukaemia/lymphoma or undergoing stem cell transplantation (SCT) were asked to complete OMDQ daily for 21 d after chemotherapy.	20947338
Peripheral Blood Stem Cells, Multiple Myeloma	Stem Cell Exhaustion	Multiple myeloma patients at peripheral blood stem cell harvest: restricted usage of TCR beta variable families.	20947434
Peripheral Blood Stem Cells, Multiple Myeloma	Stem Cell Exhaustion	The methodology was used to analyse the relative expression of 27 T-cell receptor beta variable gene families (BV families) in multiple myeloma patients undergoing peripheral blood stem cell harvest.	20947434
Chronic heart failure	Stem Cell Exhaustion	Stem cell transplantation associated with bypass grafting is feasible and safe in patients with chronic heart failure with low ejection fractions, and it improves ventricular systolic function and functional class.	20947595
Chronic heart failure	Stem Cell Exhaustion	From June 2004 to October 2007, 34 patients with chronic heart failure and low ejection fraction underwent surgical revascularization; 23 received bypass grafting plus transplantation of bone marrow-derived stem cells (study group) and 11 had revascularization only (control group).	20947595
Merkel Cell Polyomavirus Infection, Neoplasms, Merkel cell carcinoma	Stem Cell Exhaustion	Association of Merkel cell polyomavirus infection with tumor p53, KIT, stem cell factor, PDGFR-alpha and survival in Merkel cell carcinoma.	20949558
Colorectal Carcinoma	Stem Cell Exhaustion	Bone morphogenetic protein 4 induces differentiation of colorectal cancer stem cells and increases their response to chemotherapy in mice.	20951698
Colorectal Carcinoma	Stem Cell Exhaustion	The limited clinical response observed in many patients with colorectal cancer may be related to the presence of chemoresistant colorectal cancer stem cells (CRC-SCs).	20951698
Colorectal Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	BMP4 might be developed as a therapeutic agent against cancer stem cells in advanced colorectal tumors.	20951698
Neoplasms	Stem Cell Exhaustion	The tumour was treated initially with neoadjuvant chemotherapy, followed by dose escalation, peripheral blood stem cell transplantation and resection of the lesion.	20952750
Graft-vs-Host Disease	Stem Cell Exhaustion	Gastrointestinal pathology of autologous graft-versus-host disease following hematopoietic stem cell transplantation: a clinicopathological study of 17 cases.	20953169
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease is the major complication after allogeneic hematopoietic stem cell transplantation and is attributable to donor T-cell recognition of recipient alloantigens.	20953169
Graft-vs-Host Disease	Stem Cell Exhaustion	In patients undergoing autologous hematopoietic stem cell transplantation in which there is no genetic disparity to induce an alloresponse, a syndrome similar to allogeneic graft-versus-host disease has been described.	20953169
Graft-vs-Host Disease, Multiple Myeloma	Stem Cell Exhaustion	We report the development of autologous graft-versus-host disease following hematopoietic stem cell transplantation in 17 patients (15 with multiple myeloma) based on 388 autologous stem cell transplants carried out at our institution over a 6-year period.	20953169
Graft-vs-Host Disease, Multiple Myeloma	Stem Cell Exhaustion	Patients treated with autologous hematopoietic stem cell transplantation, particularly those with multiple myeloma, may develop a potentially life-threatening syndrome pathologically identical to allogeneic graft-versus-host disease.	20953169
Gastrointestinal symptom	Stem Cell Exhaustion	This diagnosis must be considered when interpreting biopsies from patients with gastrointestinal symptoms following autologous hematopoietic stem cell transplantation.	20953169
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Effects of intracoronary injection of autologous bone marrow-derived stem cells on natriuretic peptides and inflammatory markers in patients with acute ST-elevation myocardial infarction.	20953959
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Intracoronary administration of autologous bone marrow stem cells (BMC) has been shown to result in a subtle improvement of global left ventricular ejection fraction after ST-elevation myocardial infarction (STEMI), but the overall benefits of BMC therapy are still unclear.	20953959
Degenerative polyarthritis	Stem Cell Exhaustion	The potential of stem cells to repair compromised cartilage tissue, such as in osteoarthritis (OA), depends strongly on how transplanted cells respond to factors secreted from the residing OA chondrocytes.	20954186
Degenerative polyarthritis	Stem Cell Exhaustion	This study was undertaken to determine the effect of morphogenetic signals from OA chondrocytes on chondrogenic differentiation of human mesenchymal stem cells (MSCs).	20954186
Prostatic Intraepithelial Neoplasias, Prostate carcinoma	Stem Cell Exhaustion	Expression of prostate stem cell antigen in high-grade prostatic intraepithelial neoplasia and prostate cancer.	20955382
Prostatic Intraepithelial Neoplasias, Atrophic, Adenocarcinoma of prostate, Passive Cutaneous Anaphylaxis	Stem Cell Exhaustion	To investigate prostate stem cell antigen (PSCA) and Ki-67 expression in normal-looking epithelium (NEp), atrophy, high-grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma (PCa).	20955382
Inflammation	Stem Cell Exhaustion	Ambulatory blood pressure, heart rate, endothelium-dependent and -independent vasodilatation, platelet function, endothelial progenitor cells, markers of the renin-angiotensin system, inflammation, and oxidative stress were determined at baseline and after each treatment period.	20956208
Multiple Myeloma	Stem Cell Exhaustion	The primary aim of this retrospective study was to compare reinfused CD34(+) cell dose, assessed from the fresh collection, with the post-thaw viable (v) CD34(+) and vCD34/CXCR4(+) dual positive cell dose as predictors of haematopoietic recovery in multiple myeloma patients undergoing autologous stem cell transplantation.	20957366
Multiple Myeloma	Stem Cell Exhaustion	Cryopreserved samples from stem cell collections of 27 myeloma patients were analysed for CD34 and CXCR4 expression and times to haematological engraftment measured.	20957366
Malignant neoplasm of thyroid	Stem Cell Exhaustion	Tumorigenic and metastatic activity of human thyroid cancer stem cells.	20959469
Malignant neoplasm of thyroid, Neoplasms, Aggressive course, Thyroid carcinoma	Stem Cell Exhaustion	Orthotopic injection of minute numbers of thyroid cancer stem cells recapitulates the behavior of the parental tumor, including the aggressive metastatic features of undifferentiated thyroid carcinomas, which are sustained by constitutive activation of cMet and Akt in thyroid cancer stem cells.	20959469
Liver Failure, Kidney Failure	Stem Cell Exhaustion	Comorbidities significantly decreased survival to 33% for those with renal failure (n = 329), 16% with liver failure (n = 51), and 5% with hematopoietic stem cell transplantation (n = 22).	20959787
Acidophil Stem Cell Pituitary Gland Adenoma, Neoplasms, Acromegaly	Stem Cell Exhaustion	Fugitive acromegaly is most commonly caused by pituitary acidophil stem cell adenomas, and is characterized by a relatively short clinical history, a large and locally invasive tumor, and relatively low hormonal activity.	20960094
GDC Disease Response Terminology, MYELOPROLIFERATIVE SYNDROME, TRANSIENT	Stem Cell Exhaustion	A 56 year-old, multiparous woman suffering from a myeloproliferative syndrome, who had received multiple red blood cell and platelet transfusions, was the recipient of an allograft of peripheral blood stem cells derived from her HLA-A, B, DR, DQ and DP and ABO identical sister, following myeloablative conditioning.	20961787
Allogeneic Hematopoietic Stem Cell Transplantation, Hematological Disease, nervous system disorder	Stem Cell Exhaustion	Plasma was collected by machine and combined with low-molecular-weight dextran and albumin for use as a replacement fluid for TPE treatment of 43 patients suffering from various blood disorders, diseases of the nervous system, ABO incompatible allogeneic hematopoietic stem cell transplantation and kidney disease.	20961812
Angiosarcoma of spleen	Stem Cell Exhaustion	Long-term survival of a patient with splenic angiosarcoma after resection, high-dose chemotherapy, and autologous peripheral blood stem cell transplantation.	20962445
Bronchiolitis Obliterans	Stem Cell Exhaustion	[A case of bronchiolitis obliterans caused by allogeneic hematopoietic stem cell transplantation diagnosed with a body plethysmograph].	20963951
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 19-year-old woman with acute myeloid leukemia (M1) was treated with allogeneic hematopoietic stem cell transplantation.	20963951
Brain Injuries	Stem Cell Exhaustion	Significant recovery of brain function through neural stem cell implantation has been shown in several animal models of brain damage, but remains to be investigated in detail in neonates.	20964621
Sarcoma, Myeloid, Plasmacytoma, Multiple Myeloma	Stem Cell Exhaustion	A 44-yr-old man with IgG-lambda multiple myeloma reached a complete response after induction chemotherapy and autologous stem cell transplantation and maintenance therapy with interferon a2b and prednisone 4 yr later, he presented an increase in the M-protein plus extramedullary myeloma involvement with sacrum and clivus plasmacytomas.	20964719
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	A phase I trial of high-dose clofarabine, etoposide, and cyclophosphamide and autologous peripheral blood stem cell transplantation in patients with primary refractory and relapsed and refractory non-Hodgkin lymphoma.	20965266
Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	We conducted a phase I trial to determine the maximum tolerated dose (MTD) of clofarabine in combination with high-dose etoposide and cyclophosphamide followed by autologous peripheral blood stem cell transplantation in patients with refractory non-Hodgkin lymphoma (NHL).	20965266
Malignant Neoplasms	Stem Cell Exhaustion	Patients who had undergone immunomodulatory treatment (apart from interferon a), treatment for other malignancies, or allogeneic haemopoietic stem-cell transplantation were not included.	20965785
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Infusion of HLA-mismatched peripheral blood stem cells improves the outcome of chemotherapy for acute myeloid leukemia in elderly patients.	20966170
Liver carcinoma, HCCS gene, Aggressive behavior, Specialty Type - cancer	Stem Cell Exhaustion	Hepatocellular carcinomas (HCCs) with expression of stem/progenitor cell markers including CD133 have been reported to have more aggressive biological behavior, and epithelial-mesenchymal transition (EMT), closely related invasion, has been suggested to generate cancer stem cells.	20969862
Specialty Type - cancer	Stem Cell Exhaustion	Recently, it was reported that hypoxic conditions were correlated with cancer stem cell generation.	20970309
Pathology, Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	The pathologies of paroxysmal nocturnal hemoglobinuria (PNH) are primarily caused by somatic mutation in the PIG-A gene in hematopoietic stem cells resulting in glycosyl phosphatidylinositol deficiency and accumulation of phosphatidylinositol (PI) in plasma membranes.	20970669
bone marrow fibrosis, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Allogeneic stem cell transplantation for myelodysplastic syndromes with bone marrow fibrosis.	20971823
bone marrow fibrosis, Fibrosis Assessment, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Bone marrow fibrosis in patients with myelodysplastic syndrome is associated with a poor outcome, but whether the outcome after allogeneic stem cell transplantation is related to the degree of bone marrow fibrosis is unknown.	20971823
bone marrow fibrosis, Fibrosis Assessment, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Patients with myelodysplastic syndrome and known bone marrow histology (n=721) who underwent hematopoietic stem cell transplantation were classified according to the degree of bone marrow fibrosis into those without fibrosis (n=483), those with mild or moderate fibrosis (n=199) and those with severe fibrosis (n=39) and analyzed regarding engraftment, treatment-related mortality, relapse and survival.	20971823
bone marrow fibrosis, Fibrosis Assessment, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Among patients with myelodysplastic syndromes, only severe fibrosis affects survival after hematopoietic stem cell transplantation while patients with mild or moderate fibrosis have an outcome comparable to that of patients without bone marrow fibrosis.	20971823
Malignant Neoplasms, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	By day 21 post-vaccination, protective antibody titers of 1:32 or more were seen in 100% of controls compared to 39% of patients with B-cell malignancies (P<0.001), 46% of allogeneic stem cell transplant recipients (P<0.001) and 85% of patients with chronic myeloid leukemia (P=0.086).	20971824
Malignant Neoplasms, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	After a second dose, seroprotection rates increased to 68%, (P=0.008), 73%, (P=0.031), and 95% (P=0.5) in patients with B-cell malignancies, after allogeneic stem cell transplantation and with chronic myeloid leukemia, respectively.	20971824
Hemangioblastoma	Stem Cell Exhaustion	Hemangioblastomas might derive from neoplastic transformation of neural stem cells/progenitors in the specific niche.	20974685
Angina Pectoris	Stem Cell Exhaustion	Intracoronary autologous CD34+ stem cell therapy for intractable angina.	20975266
Angina Pectoris	Stem Cell Exhaustion	Laboratory and preclinical studies have provided evidence for the safety and potential efficacy of autologous CD34+ stem cell therapies as treatment for angina.	20975266
Angina Pectoris	Stem Cell Exhaustion	Clinical studies investigating intramyocardial transplantation of autologous CD34+ stem cells by catheter injection for patients with refractory angina show that this is safe and feasible.	20975266
Angina Pectoris	Stem Cell Exhaustion	It remains unclear whether intracoronary infusion of CD34+ stem cells exerts beneficial effects in patients with angina as well.	20975266
Rhabdomyosarcoma	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation against recurrent rhabdomyosarcoma.	20975586
Toxic effect	Stem Cell Exhaustion	Secondary objectives were to determine toxicity and to evaluate if response was associated with change in number of circulating endothelial cells or circulating endothelial progenitor cells.	20976541
Hematological Disease	Stem Cell Exhaustion	To describe activities in the field of autologous stem cell transplantation in haematological disorders in the Netherlands in the periods before and after 1993 (at that time blood was introduced as source of stem cells).	20977803
Lymphoma, Non-Hodgkin, Familial, Morular Metaplasia of the Endometrium	Stem Cell Exhaustion	The number of autologous stem cell transplantations has increased considerably since 1993, especially in patients with MM and NHL.	20977803
Dilated Cardiomyopathy Pathway	Stem Cell Exhaustion	Almost half of the children with symptomatic dilated cardiomyopathy receive a transplant or die within 2 years; however, cardiac stem cell transplantation has become a promising therapeutic option.	20977823
Neoplasms	Stem Cell Exhaustion	Positive selection of undifferentiated progenitor cells required the expression of the tumor suppressor protein p53.	20978349
Hematopoietic stem cells	Stem Cell Exhaustion	Treatment with androgen and methylprednisolone was started due to unavailability of a matched-related hematopoietic stem cell donor.	20979174
Nephrotic Syndrome, Multiple Myeloma	Stem Cell Exhaustion	After high-dose melphalan and autologous peripheral blood stem cell transplantation (PBSCT), the multiple myeloma and nephrotic syndrome were in complete remission; her renal function was improved, but a renal biopsy performed 6 months after PBSCT showed the persistence of diffuse and nodular lesions.	20979947
Kidney Failure, Chronic, Cardiovascular Diseases	Stem Cell Exhaustion	Chronic renal failure patients have a high cardiovascular disease burden, low numbers and impaired function of endothelial progenitor cells (EPCs).	20980359
Heart failure	Stem Cell Exhaustion	Circulating stem cell vary with NYHA stage in heart failure patients.	21029373
Heart failure	Stem Cell Exhaustion	We have investigated the blood levels of sub-classes of stem cells (SCs) [mesenchymal stem cells (MSCs), haematopoietic stem cells (HSCs), endothelial progenitor cells/circulating endothelial cells (EPCs/CECs) and tissue-committed stem cells (TCSCs)] in heart failure (HF) patients at different stage of pathology and correlated it with plasmatic levels of proangiogenic cytokines.	21029373
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	The patients participated in the Autologous Stem Cell Transplantation in Acute Myocardial Infarction (ASTAMI) trial.	21029812
Smoking, Coronary Arteriosclerosis	Stem Cell Exhaustion	Smoking is associated with depletion of circulating endothelial progenitor cells and elevated pulmonary artery systolic pressure in patients with coronary artery disease.	21029820
physiopathological, Smoking	Stem Cell Exhaustion	Smoking is associated with depletion of endothelial progenitor cells (EPCs) and may subsequently contribute to the development of vascular dysfunction.	21029820
Neoplasms, Multiple Myeloma	Stem Cell Exhaustion	Adoptive transfer of tumor antigen vaccine-primed and costimulated T cells leads to augmented and accelerated cellular and humoral immune reconstitution, including antitumor immunity, after autologous stem cell transplantation for myeloma.	21030558
leukemia	Stem Cell Exhaustion	Notch signaling regulates the fate of hematopoietic stem cells and leukemia cells.	21036721
Leukemia, Myelocytic, Acute, Multiple Myeloma	Stem Cell Exhaustion	Simultaneous acute myeloid leukemia and multiple myeloma successfully treated with allogeneic stem cell transplantation.	21037523
Leukemia, Myelocytic, Acute, Multiple Myeloma	Stem Cell Exhaustion	We present a case of concurrent diagnosis of acute myeloid leukemia (AML) with multiple myeloma with complex karyotype, which was successfully treated with allogeneic stem cell transplantation.	21037523
Leukemia, Myelocytic, Acute, Multiple Myeloma	Stem Cell Exhaustion	To our knowledge, this is the first case of a patient with simultaneous AML and multiple myeloma who has undergone successful treatment with allogeneic stem cell transplantation.	21037523
Adult T-Cell Lymphoma/Leukemia, leukemia, BAALC gene	Stem Cell Exhaustion	In concordance, gene expression profiles of 86 T-ALL patients revealed upregulation of stem cell markers (CD34 and CD133) as well as genes associated with poor outcome and pathogenesis of leukemia (MN1, BAALC, FLT3) in the high IGFBP7 expression group.	21040219
Echinococcosis, Hepatic, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Successful allogeneic hematopoietic stem cell transplantation for acute myelogenous leukemia in a patient with hepatic echinococcal cyst managed by delayed hepatectomy.	21040282
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We report the case of a patient who underwent cytotoxic chemotherapy and allogeneic hematopoietic stem cell transplantation (HSCT) for acute myelogenous leukemia in the presence of hepatic cystic echinococcal infection.	21040282
Stem Cell Factor	Stem Cell Exhaustion	The aim of this study was to assay EPC mobilizing factors, including granulocyte colony-stimulating factor, stem cell factor/c-kit ligand (SCF), vascular endothelial growth factor, and stromal cell-derived factor-1 levels, in patients with MS (n = 36) and age- and gender-matched controls (n = 38).	21040691
Metabolic Syndrome X	Stem Cell Exhaustion	Circulating levels of endothelial progenitor cell mobilizing factors in the metabolic syndrome.	21040691
Stem Cell Factor	Stem Cell Exhaustion	In conclusion, in addition to progenitor cell exhaustion as a mechanism for the decrease in EPCs in patients with MS, they also have a mobilization defect, as manifested by decreased levels of granulocyte colony-stimulating factor and SCF, resulting in a decrease in EPCs.	21040691
Malignant tumor of colon	Stem Cell Exhaustion	These results suggest that effective chemoprevention of colon cancer by NSAIDs lies in the elimination of stem cells that are inappropriately activated by oncogenic events through induction of apoptosis.	21041628
Bone marrow hypocellularity	Stem Cell Exhaustion	Bone marrow failure is the principal cause of early mortality, and stem cell transplantation is the only cure for these patients.	21042011
Toxic effect	Stem Cell Exhaustion	Outcome, toxicity profile and cost analysis of autologous stem cell mobilization.	21042307
Primary Myelofibrosis	Stem Cell Exhaustion	Retrospective study of allogeneic haematopoietic stem-cell transplantation for myelofibrosis.	21042309
Primary Myelofibrosis	Stem Cell Exhaustion	Allogeneic haematopoietic stem-cell transplantation (HSCT) is the only curative treatment for myelofibrosis.	21042309
Liver carcinoma	Stem Cell Exhaustion	Complete response in 5 out of 38 patients with advanced hepatocellular carcinoma treated with stem cell differentiation stage factors: case reports from a single centre.	21044000
Chronic myeloproliferative disorder, Hematopoietic Neoplasms, peripheral blood, DPM1 gene	Stem Cell Exhaustion	Chronic myeloproliferative disorders (MPDs) are clonal haematopoietic stem cell malignancies characterised by an accumulation of mature myeloid cells in bone marrow and peripheral blood.	21045235
Paroxysmal nocturnal hemoglobinuria, Hemolysis (biological function), Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal stem cell disorder characterized by complement-mediated hemolysis due to reduced expression of glycosyl phosphatidylinositol-anchored complement deactivating proteins such as CD55 and CD59 on RBC.	21045396
PPP1R13L wt Allele, Multiple Myeloma	Stem Cell Exhaustion	The importance of a sub-region on chromosome 19q13.3 for prognosis of multiple myeloma patients after high-dose treatment and stem cell support: a linkage disequilibrium mapping in RAI and CD3EAP.	21046104
Glioblastoma Multiforme Pathway, Neoplasms	Stem Cell Exhaustion	We report a rare case of epileptogenic glioma composed of glial progenitor cells that differentiated into an astrocytic and oligodendrocytic tumor.	21046316
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	The pathological diagnosis was epileptogenic glioma (grade I) composed of glial progenitor cells.	21046316
Chronic idiopathic neutropenia	Stem Cell Exhaustion	Mesenchymal stem cells contribute to the abnormal bone marrow microenvironment in patients with chronic idiopathic neutropenia by overproduction of transforming growth factor-b1.	21047210
Cervical Intraepithelial Neoplasia	Stem Cell Exhaustion	In this study, we investigated the possible involvement of BM mesenchymal stem cells (MSCs) in the pathophysiology of CIN by assessing the frequency and function of BM MSCs in terms of the proliferative/clonogenic characteristics, the differentiation capacity, the potential to produce pro-inflammatory cytokines, and the ability to suppress T-cell proliferation.	21047210
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Networks of oncogenes and tumor suppressor genes that control cancer cell proliferation also regulate stem cell renewal and possibly stem cell aging.	21047255
Neoplasms	Stem Cell Exhaustion	By following this methodological approach, we recently obtained data fitting a model in which, in response to chronic impairment of cellular bioenergetics imposed by metformin-induced mitochondrial uncoupling as assessed by the phosphorylation state of cAMP-response element binding protein (CREB), tumor cells can retrogress from a differentiated state to a more CD44(+) stem-like primitive state epigenetically governed by the Polycomb-group suppressor BMI1-a crucial "stemness" gene involved in the epigenetic maintenance of adult stem cells.	21047255
Multiple Myeloma	Stem Cell Exhaustion	Total marrow irradiation: a new ablative regimen as part of tandem autologous stem cell transplantation for patients with multiple myeloma.	21047977
VWF wt Allele	Stem Cell Exhaustion	ECs expanded from blood-derived endothelial progenitor cells of VWD patients confirmed these results.	21048155
Neoplasms	Stem Cell Exhaustion	CGN and NMN are neural crest stem cell-derived tumors that exhibit overlapping and unique phenotypic traits.	21048488
Cis Golgi network	Stem Cell Exhaustion	Although transformation of an intradermal melanocytic nevus to CGN is a theoretical possibility, the multiple coexisting phenotypes they display most likely arose ab initio in the dermis, mirroring the multiple pathways of differentiation possible for neural crest stem cells.	21048488
Stomatitis	Stem Cell Exhaustion	Palifermin is a modified human keratinocyte growth factor (KGF) given to decrease the incidence and duration of severe oral mucositis in patients receiving myelotoxic chemotherapy followed by a hematopoietic stem cell transplant.	21049730
Scleroderma , Sample Size Calculation	Stem Cell Exhaustion	Results of previous studies on the level of circulating endothelial progenitor cells (EPCs), which are involved in vascular repair, in scleroderma (SSc) patients have been controversial.	21050541
SERPINB3 wt Allele, Specialty Type - cancer	Stem Cell Exhaustion	Furthermore, discussion of the hypothesis of cancer stem cell biology in OSCC would be anticipated.	21057559
Cessation of life, Specialty Type - cancer	Stem Cell Exhaustion	Beside the recent hypothesis of cancer stem cells, the consideration of its cell death and cell proliferation has emerged as important diagnostic and prognostic tools.	21057559
Specialty Type - cancer	Stem Cell Exhaustion	Furthermore, deregulation of cell cycle control might aid in the attainment of genetic changes in normal stem cells to be altered to cancer stem cells.	21057559
Cerebral Ischemia	Stem Cell Exhaustion	Endothelial progenitor cells in patients with acute cerebrovascular ischemia.	21059541
Cardiovascular Diseases	Stem Cell Exhaustion	Statins have been shown to increase endothelial progenitor cells (EPCs) in patients with cardiovascular disease.	21059541
Ewings sarcoma, Neoplasms	Stem Cell Exhaustion	Nonmetastatic Ewing family tumors: high-dose chemotherapy with stem cell rescue in poor responder patients.	21059639
Hematologic Neoplasms	Stem Cell Exhaustion	Stem cell transplantation using non-myeloablative conditioning regimen with fludarabine for hematological malignancies.	21060236
Hematologic Neoplasms	Stem Cell Exhaustion	Stem cell transplantation (SCT) is a useful treatment for hematological malignancies, but it is limited to younger patients because of its high treatment-related mortality.	21060236
Toxic effect	Stem Cell Exhaustion	No severe toxicity related conditioning regimens was observed in our patients, even though there were 10 patients with a history of autologous (n = 5) or allogeneic stem cell transplantation (n = 5).	21060236
Hematologic Neoplasms	Stem Cell Exhaustion	We concluded that stem cell transplantation using a non-myeloablative conditioning regimen with Flu was a useful therapeutic approach for patients with hematological malignancies.	21060236
Liver carcinoma, Hollings Cancer Center	Stem Cell Exhaustion	Cytokeratin 19 (CK19), a molecular marker of hepatic progenitor cells and cholangiocytes, is expressed in hepatocellular carcinomas (HCC), but not in normal hepatocytes.	21061181
Neoplasms	Stem Cell Exhaustion	There is mounting evidence for sarcomatoid transformation from the epithelial component, supporting the theory that SpCC is a monoclonal neoplasm originating from a stem cell giving rise to both components.	21070371
Specialty Type - cancer	Stem Cell Exhaustion	It is now believed that cancer often is a stem cell (SC)-based disease, and there is no reason to think cancer induced by developmental chemical exposure is any different.	21071725
Specialty Type - cancer	Stem Cell Exhaustion	Arsenic, stem cells, and the developmental basis of adult cancer.	21071725
Cardiovascular Diseases	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPC), involved in endothelial regeneration, neovascularisation, and determination of prognosis in cardiovascular disease can be characterised with functional assays or using immunofluorescence and flow cytometry.	21072182
Specialty Type - cancer, Squamous cell carcinoma	Stem Cell Exhaustion	Cancer stem cell immunophenotypes in oral squamous cell carcinoma.	21073537
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	The presence of cancer stem cell (CSC) antigens can be evidenced in some human tumors by phenotypic analysis through immunostaining.	21073537
Lymphoma	Stem Cell Exhaustion	With the eventual goal of reducing relapse and thus improving overall survival in selected lymphoma patients, a Phase I study was performed using the cytoprotectant amifostine to permit safe dose-augmentation of melphalan in the carmustine (BCNU), etoposide, cytarabine (arabinosylcytosine), and melphalan (BEAM) regimen before autologous hematopoietic stem cell transplantation.	21074630
Multiple Myeloma	Stem Cell Exhaustion	Characterization of hematopoietic stem cell subsets from patients with multiple myeloma after mobilization with plerixafor.	21077729
Degenerative polyarthritis	Stem Cell Exhaustion	To quantify cells expressing mesenchymal stem cell (MSC) markers in synovial membranes from human osteoarthritic (OA) and healthy joints.	21078714
Necrosis	Stem Cell Exhaustion	Areas of necrotic skin were reduced after the first mesenchymal stem-cell infusion.	21079220
Acute myocardial infarction	Stem Cell Exhaustion	In experimental models of acute myocardial infarction, mesenchymal stem cells led to the recovery of cardiac function through the formation of a new vascular network.	21079220
Systemic Scleroderma, Ischemia	Stem Cell Exhaustion	To describe treatment with intravenous infusions of expanded autologous mesenchymal stem cells in 1 patient with critical limb ischemia due to systemic sclerosis.	21079220
Skin necrosis, Systemic Scleroderma, Peripheral Ischemia	Stem Cell Exhaustion	In patients with systemic sclerosis who have severe peripheral ischemia, intravenous infusion of expanded autologous mesenchymal stem cells may foster the recovery of the vascular network, restore blood flow, and reduce skin necrosis.	21079220
Lymphoma	Stem Cell Exhaustion	Equivalence of pegfilgrastim and filgrastim in lymphoma patients treated with BEAM followed by autologous stem cell transplantation.	21079406
HODGKINS AND NON-HODGKINS LYMPHOMA	Stem Cell Exhaustion	To evaluate the impact of pegfilgrastim on engraftment, hospital stay and resources in patients with Hodgkin's and non-Hodgkin's lymphoma after conditioning with high-dose BEAM followed by autologous peripheral blood stem cell transplantation (APBSCT) compared with filgrastim.	21079406
Multiple Myeloma	Stem Cell Exhaustion	Several pilot studies and two randomized trials have evaluated the role of bortezomib-based combinations as induction therapy in myeloma patients who are candidates for transplant, showing high efficacy (>80% response rate with 20-30% complete remission), which increased after autologous stem cell transplant.	21083004
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Imatinib is safe and effective in treating pediatric CML where stem cell transplant in not available.	21083363
Neoplasms	Stem Cell Exhaustion	However, chemotherapy-resistant tumors relapsed, and allogeneic hematopoietic stem cell transplantation was performed at 17 months.	21083707
Peripheral Stem Cell Transplantation, Multiple Myeloma	Stem Cell Exhaustion	Consequences of ABO incompatibility in multiple myeloma patients undergoing peripheral blood stem cell transplantation after reduced intensity conditioning.	21084015
Multiple Myeloma	Stem Cell Exhaustion	We retrospectively analysed data from 19 multiple myeloma patients included in a prospective RIC allogeneic haematopoietic progenitor cell transplantation protocol, focusing on engraftment, transfusion requirement, Graft-versus-Host Disease, transplant-related mortality and survival.	21084015
Hematologic Neoplasms, Pulmonary Aspergillosis	Stem Cell Exhaustion	Galactomannan testing in bronchoalveolar lavage fluid facilitates the diagnosis of invasive pulmonary aspergillosis in patients with hematologic malignancies and stem cell transplant recipients.	21087680
Hematologic Neoplasms, Pulmonary Aspergillosis	Stem Cell Exhaustion	Invasive pulmonary aspergillosis (IPA) is a major cause of mortality in patients with stem cell transplants and hematologic malignancies.	21087680
Metabolic Syndrome X, Childhood Breast Carcinoma, Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Earlier studies from our group have revealed that clinically-relevant concentrations of the biguanide derivative metformin, the most widely used oral agent to lower blood glucose concentration in patients with type 2 diabetes and metabolic syndrome, notably decreased both the self-renewal and the proliferation of trastuzumab-refractory breast cancer stem cell populations.	21088486
TGIF1 gene, Fibrosis Assessment, Specialty Type - cancer	Stem Cell Exhaustion	Metformin against TGFb-induced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis.	21088486
Specialty Type - cancer	Stem Cell Exhaustion	TGFb-driven EMT is sufficient to generate migrating cancer stem cells by directly linking the acquisition of cellular motility with the maintenance of tumor-initiating (stemness) capacity.	21088486
Zebrafish, Specialty Type - cancer	Stem Cell Exhaustion	tumor-initiating cancer stem cells display a significant enrichment in the expression of basal/mesenchymal or myoepithelial markers, including an increased secretion of TGFb; b.)	21088486
TGIF1 gene	Stem Cell Exhaustion	ZEB1, TWIST1, SNAIL2 [Slug], TGFbs), we recently hypothesized that prevention of TGFb-induced EMT might represent a common molecular mechanism underlying the anti-cancer stem cells and anti-fibrotic actions of metformin.	21088486
Pancytopenia	Stem Cell Exhaustion	Effect of splenectomy on pancytopenia after a peripheral blood stem cell transplantation.	21092413
Pancytopenia, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	To analyze the effect of a splenectomy on pancytopenia after a peripheral blood stem cell transplantation (PBSCT) in chronic myeloid leukemia (CML) patients.	21092413
Communicable Diseases	Stem Cell Exhaustion	From Oct. 2004 to Oct. 2009, 104 cases of graft occlusion were treated in 53 patients with lower extremity arterial bypasses, including medical therapy for 10 cases and redo operations for 94 cases: graft thrombectomy alone for 26 cases, redo bypass or extension bypass with prosthetic or autologous vein grafts for 23 cases, graft thrombectomy plus balloon angioplasty for 18 cases, major amputation for 14 cases, graft thrombectomy plus femoral or popliteal artery endarterectomy for 10 cases, removal of occluded graft with infection for 2 case, and autologous stem cell transplantation for 1 case.	21092492
Chronic heart failure, Congestive heart failure	Stem Cell Exhaustion	We studied the effect of a short-term (3 weeks) exercise training program on the number of circulating CD34/KDR(+) endothelial progenitor cells (EPCs) and on serum levels of matrix metalloproteinases (MMPs) in chronic heart failure (CHF) patients as well as on serum capacity to foster colony forming units-endothelial cells (CFU-ECs) in vitro.	21094549
Infarction	Stem Cell Exhaustion	Animal models of ischemia/reperfusion have demonstrated that single-dose erythropoietin may reduce infarct size, decrease apoptosis, and increase neovascularization, possibly through mobilization of endothelial progenitor cells.	21095264
Cerebrovascular Trauma	Stem Cell Exhaustion	Vascular trauma induced by surgical revascularization stimulates mobilization of hematopoietic and nonhematopoietic progenitor cells.	21095342
Adult Glioblastoma	Stem Cell Exhaustion	Ten paired samples of glioblastoma and respective glioblastoma-derived spheres (GS), cultured under stem cell conditions, were analyzed for the degree and pattern of MGMT promoter methylation by methylation-specific clone sequencing, MGMT gene dosage, chromatin status, and respective effects on MGMT expression and MGMT activity.	21097691
Limbal stem cell deficiency	Stem Cell Exhaustion	Participants This study involved 19 eyes of 17 patients who received autologous COMET for total limbal stem-cell deficiency.	21097786
Multiple Myeloma	Stem Cell Exhaustion	A 38-year-old man with multiple myeloma and dialysis-dependent renal failure was evaluated for stem cell transplantation.	21098756
Lymphoma, Non-Hodgkin, Multiple Myeloma	Stem Cell Exhaustion	Plerixafor is a chemokine receptor 4 antagonist approved for use to mobilize stem cells for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma.	21098756
Malignant neoplasm of testis	Stem Cell Exhaustion	Plerixafor enables successful hematopoietic stem cell collection in an extensively pretreated patient with testicular cancer.	21099212
Dupuytrens Disease	Stem Cell Exhaustion	Characterization of stem cells in Dupuytren's disease.	21104823
Malignant neoplasm of stomach	Stem Cell Exhaustion	CD44 is a transmembrane receptor for hyaluronan and osteopontin, and has recently attracted attention as a gastric cancer stem cell marker.	21105049
Graft-vs-Host Disease	Stem Cell Exhaustion	Reduced-intensity conditioning regimens have reshaped the clinical presentation of graft-versus-host disease after hematopoietic stem cell transplants.	21106223
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation in chronic lymphocytic leukemia: results of European intergroup randomized trial comparing autografting versus observation.	21106985
Neoplasms	Stem Cell Exhaustion	When compared with their CD133- counterparts, CD133(+) cells not only possess the preferential ability to form undifferentiated tumor spheroids in vitro but also express an enhanced level of stem cell-associated genes, have a greater ability to form tumors when implanted orthotopically in immunodeficient mice, and can be serially passaged into secondary animal recipients.	21112564
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	A novel paradigm in tumor biology suggests that cancer growth is driven by stem-like cells within a tumor, called tumor-initiating cells (TICs) or cancer stem cells (CSCs).	21112564
Primary Neoplasm	Stem Cell Exhaustion	After surgery on primary tumour, a fifth course with vincristine, doxorubicin and CPM was given, followed by high-dose chemotherapy with stem cell support.	21112775
Hematologic Neoplasms	Stem Cell Exhaustion	Psychological distress as a negative survival factor for patients with hematologic malignancies who underwent allogeneic hematopoietic stem cell transplantation.	21114391
Cessation of life, Hematologic Neoplasms	Stem Cell Exhaustion	To evaluate the influence of distress on overall survival of patients with hematologic malignancies who underwent allogeneic stem cell transplantation (allo-SCT) and to analyze the possible risk factors for death.	21114391
Neoplasms	Stem Cell Exhaustion	Sp100 as a potent tumor suppressor: accelerated senescence and rapid malignant transformation of human fibroblasts through modulation of an embryonic stem cell program.	21118961
Graft-vs-Host Disease, Opportunistic Infections, Thrombotic Microangiopathies	Stem Cell Exhaustion	Transplantation-associated thrombotic microangiopathy (TA-TMA) is a rare but devastating syndrome that occurs in allogeneic hematopoietic stem cell transplant recipients, and is associated with a variety of transplantation-related factors, including conditioning regimens, immunosuppressive agents, graft-versus-host disease (GVHD) and opportunistic infections.	21120571
Kidney Diseases, Polyserositis	Stem Cell Exhaustion	We present a case of a 37-year-old man with membranous nephropathy (MN) and polyserositis caused by GVHD after hematopoietic stem cell transplantation.	21120571
Glomerulonephritis	Stem Cell Exhaustion	Acute glomerulonephritis in a donor as a side effect of allogeneic peripheral blood stem cell mobilization with granulocyte colony-stimulating factor.	21120643
Glomerulonephritis	Stem Cell Exhaustion	Following on from the recently published articles reported side effects occurring due to donation of stem cells, we describe a case of a donor with transient, biopsy-proved acute focal segmental proliferative glomerulonephritis (GN) due to peripheral blood stem cells (PBSC) mobilization with granulocyte colony-stimulating factor (G-CSF).	21120643
Proteinuria, Nephrons	Stem Cell Exhaustion	Due to mobilization and collection of stem cells, proteinuria was becoming more intense and reached the nephrotic range.	21120643
Congestive heart failure	Stem Cell Exhaustion	Effects of rosuvastatin and allopurinol on circulating endothelial progenitor cells in patients with congestive heart failure: the impact of inflammatory process and oxidative stress.	21122851
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	Non-small cell lung cancer cells expressing CD44 are enriched for stem cell-like properties.	21124918
Specialty Type - cancer, Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	The cancer stem cell theory hypothesizes that cancers are perpetuated by cancer stem cells (CSC) or tumor initiating cells (TIC) possessing self-renewal and other stem cell-like properties while differentiated non-stem/initiating cells have a finite life span.	21124918
Malignant neoplasm of lung	Stem Cell Exhaustion	The expression profiles of five stem cell markers (CD34, CD44, CD133, BMI1 and OCT4) were screened by flow cytometry in 10 lung cancer cell lines.	21124918
Malignant neoplasm of lung	Stem Cell Exhaustion	Overall, our results demonstrated that stem cell-like properties are enriched in CD44-expressing subpopulations of some lung cancer cell lines.	21124918
Amyloidosis	Stem Cell Exhaustion	AL amyloidosis in a young adult: remission with autologous stem cell transplantation.	21125195
Primary amyloidosis	Stem Cell Exhaustion	Autologous stem cell transplant is one of the therapies employed in the treatment of primary amyloidosis or AL.	21125195
Primary amyloidosis	Stem Cell Exhaustion	The diagnosis of primary amyloidosis or AL was confirmed and the treatment proposed consisted of high-dose melphalan as conditioning regimen before autologous stem cell transplant, which determined complete remission of the disease, along with the disappearance of clinical signs and absence of the monoclonal component.	21125195
Specialty Type - cancer	Stem Cell Exhaustion	Significance of Lgr5(+ve) cancer stem cells in the colon and rectum.	21125339
Specialty Type - cancer	Stem Cell Exhaustion	Although recent studies show that leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5)(+ve) cells targeted by Wnt drive self-renewal in the skin and gastrointestinal organs, the clinicopathological significance of Lgr5(+ve) cancer stem cells (CSCs) of the colon remains to be elucidated.	21125339
Cytogenetic Complete Response	Stem Cell Exhaustion	This study supports a significant role for LGR5 in the CSC hypothesis in CRC: (1) Lgr5(+ve) CSCs, presumably derived from normal stem cells in colonic crypts, proliferate, and the gene is overexpressed during CRC development; (2) LGR5 expression is associated with activation of Wnt pathway, including oncogenic c-MYC and high energy production via glutaminolysis; (3) LGR5 expression may be a poor prognostic factor for CRC patients.	21125339
Cessation of life, Graft-vs-Host Disease, Mycoses, Acute leukemia	Stem Cell Exhaustion	Invasive fungal infections (IFI) are major causes of death in high-risk haematological patients receiving induction therapy for acute leukaemia or intensified immunosuppression due to acute or chronic graft-vs.-host disease (GvHD) following allogeneic stem cell transplantation (SCT).	21126267
Malignant neoplasm of kidney, Refractory Cytopenia of Childhood	Stem Cell Exhaustion	The chemokine receptor CXCR4 and CD133, putative stem cell markers, were previously described in renal cancer (RCC).	21127401
Pulmonary Aspergillosis, Acute lymphocytic leukemia	Stem Cell Exhaustion	A 10-year-old boy with high-risk acute lymphoblastic leukemia treated with hematopoietic stem-cell transplantation developed pulmonary aspergillosis while receiving prophylactic voriconazole.	21127455
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	To verify molecular mechanisms by which leukemia stem cells (LSCs) maintain a dormant state, we explored the activity of the major prosurvival signal pathways in CD34(+) /CD38(-) compartment, supposed to contain LSCs, and CD34(+) /CD38(+) counterparts from patients with acute myelogenous leukemia (AML, n = 11) by fluorescence-activated cell sorting (FACS).	21128225
Hematologic Neoplasms, Mycoses	Stem Cell Exhaustion	[Early antigen diagnosis of invasive fungal infection in patients with hematological malignancies and patients receiving hematopoietic stem cell transplantation].	21129281
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	High-dose ara-C (HIDAC) is the standard chemotherapy-based post-remission treatment for younger AML patients, but diagnostic cytogenetics and genetic features may mandate an allogeneic stem cell transplant.	21130410
Blood Vessel, Sepsis	Stem Cell Exhaustion	Elevated circulating endothelial cell (CEC) and circulating endothelial progenitor cell (CEPC) counts may indicate vascular damage and disease status, but data on these cell populations in patients with severe sepsis are limited.	21130783
Sepsis	Stem Cell Exhaustion	Circulating endothelial and endothelial progenitor cells in patients with severe sepsis.	21130783
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Characterization of chronic myeloid leukemia stem cells.	21132730
leukemia, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Although tyrosine kinase inhibitors have redefined the care of chronic myeloid leukemia (CML), these agents have not proved curative, likely due to resistance of the leukemia stem cells (LSC).	21132730
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Thus, ALDH activity appears to enrich for CML stem cells, which display an expression profile that is distinct from normal stem/progenitor cells and even the CML progenitors.	21132730
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	These expression patterns suggest that PROTEINASE 3, SURVIVIN, and hTERT are not optimal therapeutic targets in CML stem cells; whereas PRAME and WT1 seem promising.	21132730
Blast Phase	Stem Cell Exhaustion	We therefore isolated subsets of CD34(+) stem/progenitor cells from normal donors and from patients with chronic phase or blast crisis CML.	21132730
BCR gene	Stem Cell Exhaustion	Hyper-CVAD is an effective and tolerable induction strategy for adult ALL, and is suitable for use prior to allogeneic stem cell transplant in first complete remission.	21133717
Waldenstrom Macroglobulinemia	Stem Cell Exhaustion	In a patient with biclonal Waldenstrom macroglobulinemia only one clone expands in three-dimensional culture and includes putative cancer stem cells.	21133724
Specialty Type - cancer	Stem Cell Exhaustion	After 3-D culture, secondary culture in a colony forming unit assay, and RQ-PCR, only the V(H)4 clone was shown to harbor a subpopulation with characteristics of cancer stem cells, including proliferative quiescence, self-regeneration, and the ability to generate clonotypic progeny, suggesting that the V(H)4, but not the V(H)3, clone is clinically significant.	21133724
Primary Myelofibrosis	Stem Cell Exhaustion	Allogeneic haematopoietic stem cell transplantation for myelofibrosis: a report of the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire (SFGM-TC).	21133885
Primary Myelofibrosis	Stem Cell Exhaustion	Allogeneic haematopoietic stem-cell transplantation (HSCT) is the only curative treatment for myelofibrosis.	21133885
Decreased platelet count	Stem Cell Exhaustion	Factors affecting favourably engraftment were splenectomy before HSCT, human leucocyte antigen (HLA) matched sibling donor, peripheral stem cell use as source of stem cells and absence of pre-transplant thrombocytopenia.	21133885
Periodontal Diseases, Endothelial dysfunction, "cytidylyl-(3-5)-cytidine	Stem Cell Exhaustion	periodontal disease is associated with endothelial dysfunction and increased circulating progenitor cell (CPC) count.	21133981
filgrastim, Fever, Multiple Myeloma	Stem Cell Exhaustion	Lenograstim reduces the incidence of febrile episodes, when compared with filgrastim, in multiple myeloma patients undergoing stem cell mobilization.	21134693
Fever, Multiple Myeloma	Stem Cell Exhaustion	The aim of this study was to show a lower incidence of febrile episodes in multiple myeloma patients receiving lenograstim vs. filgrastim after high-dose cyclophosphamide for stem cell mobilization.	21134693
Acute Cerebrovascular Accidents	Stem Cell Exhaustion	Endothelial progenitor cells correlate with lesion volume and growth in acute stroke.	21135380
Vascular System Injuries, Acute Cerebrovascular Accidents	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPC) are markers of vascular injury and their numbers decrease in acute stroke.	21135380
Chronic heart failure	Stem Cell Exhaustion	There are continued debates on potential proarrhythmic effects of intracoronary bone marrow-derived progenitor cell (BMC) therapy for treatment of chronic heart failure.	21138937
Lymphoma	Stem Cell Exhaustion	We analyzed 67 patients with lymphoma who received alemtuzumab-based conditioning regimens for allogeneic stem cell transplant and no post-transplant DLI.	21142785
leukemia	Stem Cell Exhaustion	Clinical outcomes and health-related quality of life (HRQOL) following haemopoietic stem cell transplantation (HSCT) for paediatric leukaemia.	21143268
Multiple Myeloma	Stem Cell Exhaustion	Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: a randomised phase 3 study.	21146205
Trial Disease Assessments Domain, Multiple Myeloma	Stem Cell Exhaustion	We aimed to assess the efficacy and safety of addition of bortezomib to TD (VTD) versus TD alone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma.	21146205
Trial Disease Assessments Domain	Stem Cell Exhaustion	After double autologous stem-cell transplantation, patients received two 35-day cycles of their assigned drug regimen, VTD or TD, as consolidation therapy.	21146205
Multiple Myeloma	Stem Cell Exhaustion	VTD induction therapy before double autologous stem-cell transplantation significantly improves rate of complete or near complete response, and represents a new standard of care for patients with multiple myeloma who are eligible for transplant.	21146205
Neoplasms	Stem Cell Exhaustion	The variations in ages at diagnosis associated with different tumor catecholamine phenotypes and locations suggest origins of PPGLs from different chromaffin progenitor cells with variable susceptibility to disease causing mutations.	21147885
HIV Infections	Stem Cell Exhaustion	Evidence for the cure of HIV infection by CCR5D32/D32 stem cell transplantation.	21148083
HIV Infections	Stem Cell Exhaustion	In the present study, we demonstrate successful reconstitution of CD4(+) T cells at the systemic level as well as in the gut mucosal immune system after CCR5D32/D32 stem cell transplantation, while the patient remains without any sign of HIV infection.	21148083
PDX1 gene	Stem Cell Exhaustion	The presence of the neural stem cell marker nestin, duct cell marker cytokeratin 19, and endocrine cell markers C-peptide and pancreatic and duodenal homeobox 1, was also observed.	21149438
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease (aGVHD) is a major cause of morbidity and mortality after matched unrelated, related, or mismatched related donor hematopoietic stem-cell transplantation (HSCT).	21149654
Graft-vs-Host Disease, Mycoses	Stem Cell Exhaustion	Once-weekly liposomal amphotericin B for prophylaxis of invasive fungal infection after graft-versus-host disease in allogeneic hematopoietic stem cell transplantation: a comparative retrospective single-center study.	21150235
Graft-vs-Host Disease, Mycoses	Stem Cell Exhaustion	We investigated the efficacy and safety of high-dose LAmB (7.5 mg/kg once weekly) prophylaxis of fungal infections in allogeneic stem-cell transplanted (allo-SCT) patients with graft-versus-host disease (GvHD).	21150235
Malignant neoplasm of stomach	Stem Cell Exhaustion	Detection of b-catenin, gastrokine-2 and embryonic stem cell expressed ras in gastric cancers.	21151392
Myeloproliferative disease	Stem Cell Exhaustion	Increased mobilization of circulating endothelial progenitor cells may represent a new biological hallmark of myeloproliferative neoplasms.	21151606
Alzheimers Disease	Stem Cell Exhaustion	This conference report highlights selected presentations on the use of patient-specific stem cells, and neuroprotection, regeneration and cognitive enhancement strategies for the prevention or treatment of Alzheimer's disease.	21154134
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Glomerulonephritis	Stem Cell Exhaustion	Expression of stem cell marker CD133 in fetal and adult human kidneys and pauci-immune crescentic glomerulonephritis.	21154236
Kidney Diseases	Stem Cell Exhaustion	In this study, we sought to clarify the location and nature of adult renal stem cells and to address their reparative role in native kidney disease.	21154236
Liver damage	Stem Cell Exhaustion	These results suggest that adult renal stem cells reside predominantly in the S3 segment of the proximal tubule, where they remain mitotically silent under normal conditions, but can be induced by cellular injury.	21154236
Kidney Diseases	Stem Cell Exhaustion	These results also suggest a potential role for adult renal stem cells in recovery from native human kidney disease.	21154236
Amyloidosis	Stem Cell Exhaustion	Aggressive treatment of amyloid light chain (AL) amyloidosis with high-dose intravenous melphalan followed by autologous stem cell transplantation (HDM/SCT) is effective in inducing hematologic remission and clinical improvement.	21156464
Multiple Myeloma	Stem Cell Exhaustion	Outcome of patients with IgD and IgM multiple myeloma undergoing autologous hematopoietic stem cell transplantation: a retrospective CIBMTR study.	21156462
Damage	Stem Cell Exhaustion	Those with allogeneic engraftment,	21166499
Thrombotic Microangiopathies	Stem Cell Exhaustion	Renal thrombotic microangiopathy associated with chronic humoral graft versus host disease after hematopoietic stem cell transplantation.	21166941
Thrombomodulin Alfa, Thrombotic Microangiopathies	Stem Cell Exhaustion	Thrombotic microangiopathy (TMA) is a known complication of hematopoietic stem cell transplantation (HSCT).	21166941
Cerebral artery occlusion, Infarction	Stem Cell Exhaustion	We found previously that transplantation of neuronal precursors derived from BG01 human embryonic stem cells reduced infarct volume and improved behavioral outcome after distal middle cerebral artery occlusion (MCAO) in rats.	21167824
Neoplasms	Stem Cell Exhaustion	Tumor incidence in related hematopoietic stem cell donors.	21170092
Hematologic Neoplasms	Stem Cell Exhaustion	This single center retrospective cohort study evaluated all HLA-identical sibling pairs with hematopoietic stem cell transplantation (HSCT) for a hematological malignancy, treated from 1974 to 2001 at the University Hospital of Basel.	21170092
Malignant Neoplasms	Stem Cell Exhaustion	Late malignancies have been discussed as a potential risk for growth factor mobilized donors of hematopoietic stem cells.	21170092
Neoplasms	Stem Cell Exhaustion	Tumors do occur in donors of hematopoietic stem cells at least at the rate as expected in a normal population; whether incidence exceeds expected rates needs to be determined in larger international cohorts.	21170092
Sensorineural Hearing Loss (disorder)	Stem Cell Exhaustion	Endothelial progenitor cells in sudden sensorineural hearing loss.	21171834
BCR gene	Stem Cell Exhaustion	Most older adolescents with ALL can be cured with risk-adjusted intensive chemotherapy without stem-cell transplantation.	21172890
Rickets, Osteopetrosis	Stem Cell Exhaustion	Coexistence of rickets and osteopetrosis may have adverse effects on clinical response to stem cell transplantation.	21175093
Multiple Myeloma	Stem Cell Exhaustion	The objective of this investigation was to assess the effect of aprepitant on the pharmacokinetics of high-dose melphalan used as conditioning therapy before blood stem cell transplantation in multiple myeloma.	21175446
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	HDAC1 binding was significantly increased in AML blasts compared to CD34+ progenitor cells at 130 gene promoters whereas decreased binding was observed at 66 gene promoters.	21176959
Liver damage	Stem Cell Exhaustion	[Therapeutic effect of autologous bone marrow stem cell transplantation in the treatment of severe liver damage].	21177200
Liver damage	Stem Cell Exhaustion	To evaluate the effect of autologous bone marrow stem cell transplantation in the treatment of severe liver damage.	21177200
Liver damage	Stem Cell Exhaustion	Autologous bone marrow stem cell transplantation can improve the liver function of patients with severe liver damage without causing serious complications.	21177200
Atrial Fibrillation by ECG Finding	Stem Cell Exhaustion	Identifying the VOM and infusing stem cells may ablate related ganglia autonomic function and offer an innovative treatment for atrial fibrillation.	21177278
Anemia, Multiple Myeloma	Stem Cell Exhaustion	Donor cell origin of multiple myeloma occurring after allogeneic haematopoietic stem cell transplantation in a patient with refractory anaemia with ring sideroblast.	21177746
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Post-transplant lymphoproliferative disorder (PTLD) is a rare but life-threatening complication after solid organ and haematopoietic stem cell transplantation.	21177746
Anemia	Stem Cell Exhaustion	A 40-year-old woman who was diagnosed as having refractory anaemia with ring sideroblast 6 years ago took an ABO mismatched, unrelated allogeneic haematopoietic stem cell transplantation (HSCT) from a 32-year-old healthy male donor.	21177746
Post-transplant lymphoproliferative disorder, Acute lymphocytic leukemia	Stem Cell Exhaustion	Examining the origin of posttransplant lymphoproliferative disorder in a patient after a second allogeneic hematopoeitic stem cell transplantation for relapsed BCR-ABL positive acute lymphoblastic leukemia.	21178708
Fibrosis Assessment	Stem Cell Exhaustion	Epithelial-mesenchymal transition may be partially involved in the development of subepithelial corneal fibrosis due to total limbal stem cell deficiency.	21179238
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Experimental data suggests that bone marrow derived Mesenchymal Stem Cells (MSCs) may contribute to the healing of Myocardial infarction.	21180034
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder in which the diagnosis is confirmed by detection of a genetic marker: Philadelphia (Ph) chromosome in almost 90% of cases.	21180244
Hematologic Neoplasms, Respiratory Tract Infections	Stem Cell Exhaustion	Human respiratory syncytial virus (HRSV) is an important cause of respiratory infection in patients with hematological malignancy, particularly hematopoietic stem cell transplant recipients.	21181932
Delirium	Stem Cell Exhaustion	The neuropsychological course of acute delirium in adult hematopoietic stem cell transplantation patients.	21183605
Delirium	Stem Cell Exhaustion	We characterize neuropsychological performance in 54 hemapoietic stem cell/bone marrow transplantation (BMT) patients shortly before, during, and after delirium and in BMT patients without delirium and 10 healthy adults.	21183605
Neoplasms	Stem Cell Exhaustion	Putative CD133(+) brain tumor stem cells have been shown to be located in niches and as single cells.	21184132
Mesenchymal Stem Cells, Muscle, Smooth, Vascular, Progeria	Stem Cell Exhaustion	A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects.	21185252
LMNA wt Allele	Stem Cell Exhaustion	To understand the underlying molecular pathology of HGPS, we derived induced pluripotent stem cells (iPSCs) from HGPS dermal fibroblasts.	21185252
Hemorrhagic cystitis	Stem Cell Exhaustion	Efficacy and safety of ciprofloxacin for prophylaxis of polyomavirus BK virus-associated hemorrhagic cystitis in allogeneic hematopoietic stem cell transplantation recipients.	21185389
Hemorrhagic cystitis	Stem Cell Exhaustion	Polyoma virus BK-induced hemorrhagic cystitis is an important cause of morbidity after hematopoietic stem cell transplantation (HSCT).	21185389
leukemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	[General calculating model of the needs for allogenic stem cell transplantation for the patients with leukaemia and myelodysplastic syndrome in Vojvodina].	21186542
Hematological Disease	Stem Cell Exhaustion	Allogeneic stem cell transplantation (SCT) application represents a treatment of choice that enables the eradication of malignant clone and chance for remedy of the patients with hematological diseases.	21186542
PAFAH1B1 wt Allele, Myeloid Leukemia, Chronic, Chronic Lymphocytic Leukemia, Leukemia, Myelocytic, Acute, BCR gene	Stem Cell Exhaustion	Total annual needs for allogeneic SCT for the patients suffering from ANLL, ALL, CML, CLL and MDS together, in transplantation with stem cells from their related donors are 786 days, from the unrelated donors are 306 days, while for nonmyeloablative transplantation with stem cells from their related donors are 558 days and from the unrelated ones are 297 days.	21186542
Neutropenia, Fever, Pregnancy Complications, Infectious, Inflammatory	Stem Cell Exhaustion	Stem cell transplantation (SCT) is still complicated by the occurrence of fever and inflammatory complications attributed to neutropenia and subsequent infectious complications.	21188146
Myocardial Ischemia	Stem Cell Exhaustion	Improved functional activity of bone marrow derived circulating progenitor cells after intra coronary freshly isolated bone marrow cells transplantation in patients with ischemic heart disease.	21188654
Myocardial Ischemia	Stem Cell Exhaustion	In this randomized controlled study we analyzed the influence of intracoronary autologous freshly isolated bone marrow cells transplantation by use of point of care system on cardiac function and on the functional activity of bone marrow derived circulating progenitor cells (BM-CPCs) in patients with ischemic heart disease (IHD).	21188654
Lymphoma, Adverse Event Associated with Secondary Malignancy	Stem Cell Exhaustion	High-dose chemotherapy with peripheral blood progenitor cell (PBPC) autograft is effective in high-risk lymphoma, particularly with the addition of rituximab; however, it is associated with risk of secondary malignancy.	21189387
Myocardial Ischemia	Stem Cell Exhaustion	Improved mobilization of the CD34(+) and CD133(+) bone marrow-derived circulating progenitor cells by freshly isolated intracoronary bone marrow cell transplantation in patients with ischemic heart disease.	21190450
Myocardial Ischemia	Stem Cell Exhaustion	Because the role of bone marrow-derived circulating progenitor cells (BM-CPCs) after cell therapy is less clear, we analyzed in this randomized, controlled study the influence of intracoronary autologous freshly isolated bone marrow cell transplantation (BMC-Tx) by using a point-of-care system on cardiac function and on the mobilization of BM-CPCs in patients with ischemic heart disease (IHD).	21190450
Hematologic Neoplasms	Stem Cell Exhaustion	The outcomes of family haploidentical hematopoietic stem cell transplantation in hematologic malignancies are not associated with patient age.	21193055
Disease, Bone marrow hypocellularity, MYELODYSPLASTIC SYNDROME, Cytopenia, Dysplasia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Myelodysplastic syndromes (MDSs) are clonal stem cell disorders characterized by cytopenias, dysplasia in one or more cell lineages and ineffective hematopoiesis and are associated with significant morbidity and mortality due to bone marrow failure or evolution to acute myeloid leukemia.	21193364
Ischemic	Stem Cell Exhaustion	The identification of factors that mobilize subsets of endogenous progenitor cells may provide new therapeutic tools to enhance the repair of ischaemic tissue.	21193434
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Allogeneic stem cell transplantation is a potentially curative treatment for myelodysplastic syndromes.	21195312
Malignant Neoplasms	Stem Cell Exhaustion	During a 15 month period, altogether 63 patients with lymphoid malignancies were admitted to our department for blood stem cell collection.	21198864
Hematopoietic Stem Cell Mobilization	Stem Cell Exhaustion	Altogether 13/16 patients mobilized with a combination of chemomobilization and plerixafor received high-dose therapy with stem cell support and all engrafted.	21198864
Hematologic Neoplasms, Trauma, Diabetes Mellitus	Stem Cell Exhaustion	Underlying conditions included haematological malignancies (44%), trauma (15%), haematopoietic stem cell transplantation (9%) and diabetes mellitus (9%).	21199154
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In January 2005, an 18-year-old male patient with acute myeloid leukemia (AML) received a haploidentical hematopoietic stem cell transplantation (HSCT) from his father.	21199355
Multiple Myeloma	Stem Cell Exhaustion	Impairment in immunomodulatory function of mesenchymal stem cells from multiple myeloma patients.	21199732
Hemopoietic stem cell transplant, Acute lymphocytic leukemia	Stem Cell Exhaustion	A 35-year-old Caucasian man with a history of refractory acute lymphoblastic leukemia was admitted for a third allogeneic, mismatched, peripheral blood hematopoietic stem cell transplant from an unrelated donor, with a conditioning regimen that included busulfan and fludarabine.	21200060
Specialty Type - cancer	Stem Cell Exhaustion	Fetal-maternal microchimerism enhances the survival effect of interleukin-2-activated haploidentical peripheral blood stem cell treatment in patients with advanced solid cancer.	21204769
Specialty Type - cancer	Stem Cell Exhaustion	The goal of this study was to determine the clinical efficacy of KIR-ligand incompatibility and fetal-maternal microchimerism for interleukin-2-activated haploidentical peripheral blood stem cells (haplo-PBSCs) treatment for patients with advanced solid cancer.	21204769
Intrahepatic Cholangiocarcinoma, Hepatitis B, Communicable Diseases	Stem Cell Exhaustion	Recent efforts suggest an etiologic role of hepatitis B virus (HBV) infection in intrahepatic cholangiocarcinoma (ICC) and the involvement of hepatic progenitor cell in ICC development, without definitive conclusions.	21207172
Liver carcinoma, Liver Cirrhosis	Stem Cell Exhaustion	The independent association of HBV infection with ICC, synergy between cirrhosis and HBV infection, and some clinicopathological similarities between HBV-related ICC and hepatocellular carcinoma suggests that both may share similar or common tumorigenic process and may possibly originate from malignant transformation of hepatic progenitor cell.	21207172
Rheumatoid Arthritis	Stem Cell Exhaustion	In our case, it may be hypothesized that synchronous, heterogeneous mutations occurred in different type of committed cells or in stem cells, due to the production of cytokines by RA nodule histiocytes and lymphocytes, which are contiguous to the carcinomatous area.	21210348
Allogeneic Hematopoietic Stem Cell Transplantation, Chronic graft-versus-host disease	Stem Cell Exhaustion	Gene expression profile of cytokines in patients with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation with reduced conditioning.	21211989
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	There are no reliable markers useful to predict the onset or the evolution of chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (HSCT), although several candidate biomarkers have been identified from limited hypothesis-driven studies.	21211989
Central neuroblastoma	Stem Cell Exhaustion	Stem-cell-supported chemotherapy is the current treatment of choice for high-stage, high-risk neuroblastoma, as in this case.	21212023
Thrombus, Myeloproliferative disease	Stem Cell Exhaustion	Endothelial progenitor cells are clonal and exhibit the JAK2(V617F) mutation in a subset of thrombotic patients with Ph-negative myeloproliferative neoplasms.	21212285
Malignant - descriptor, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myeloid leukemia (CML) is a clonal malignant disorder of a pluripotent hematopoietic stem cell characterized by the presence of a Philadelphia (Ph) chromosome.	21212648
Graft-vs-Host Disease	Stem Cell Exhaustion	Through a retrospective analysis, we investigated the efficacy of GVHD prophylaxis with rabbit anti-thymocyte globulin (ATG) 7.5 mg/kg (1 mg/kg given on day -3, then 3.25 mg/kg/day on days -2 and -1 before stem cell infusion) followed by standard tacrolimus plus methotrexate in a consecutive series of 45 HLA partially matched unrelated donor HCT recipients.	21215811
Neutropenia, Hematologic Neoplasms, Pichia kudriavzevii	Stem Cell Exhaustion	Candida krusei candidaemia was most commonly associated with haematological malignancy (61%; P < 0.001), stem cell transplantation (22%; P = 0.004), neutropenia (57%; P = 0.001) and prior use of antifungal azole agents (26%; P < 0.001).	21216030
Ischemia, diabetic, Ulcer	Stem Cell Exhaustion	Comparison of bone marrow mesenchymal stem cells with bone marrow-derived mononuclear cells for treatment of diabetic critical limb ischemia and foot ulcer: a double-blind, randomized, controlled trial.	21216483
CLU protein, human, diabetic, Ulcer	Stem Cell Exhaustion	Under ordinary treatment, the limbs of 41 type 2 diabetic patients with bilateral CLI and foot ulcer were injected intramuscularly with bone marrow mesenchymal stem cells (BMMSCs), bone marrow-derived mononuclear cells (BMMNCs), or normal saline (NS).	21216483
Exencephaly	Stem Cell Exhaustion	Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly.	21220025
Fanconi Anemia	Stem Cell Exhaustion	In the mid-1990s, we introduced a fludarabine (Flu)-based conditioning regimen for hematopoietic stem cell transplantation (HSCT) in patients with Fanconi anemia (FA).The aim of this study is to compare Flu-based conditioning to alternative regimens in patients with FA.	21220033
Multiple Myeloma	Stem Cell Exhaustion	Increased copy number of the interleukin-6 receptor gene is associated with adverse survival in multiple myeloma patients treated with autologous stem cell transplantation.	21220034
Myocardial Ischemia	Stem Cell Exhaustion	It has been questioned whether bone marrow-derived mesenchymal stromal cells (MSCs) from patients with ischemic heart disease are suitable for use in regenerative stem cell therapy.	21222501
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	High dose chemotherapy followed by autologous stem cell transplantation (ASCT) is the preferred treatment modality for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL).	21223255
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	It was demonstrated previously that the STAT3 pathway maintains the tumorigenicity and therapeutic resistance of malignant tumors as well as cancer stem cells (CSCs).	21225866
Uremia	Stem Cell Exhaustion	In this study we evaluate the effect of uremia on LDL carbamylation and the effect of cLDL and oxidized LDL (oxLDL; 200 mg/ml) on number, function, and genomic stability of endothelial progenitor cells (EPCs) obtained from healthy volunteers.	21228221
Breast Carcinoma, Autoimmune Diseases, Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	The 13 cases studied included 5 bone marrow/stem cell transplantations, 3 solid organ transplantations, 1 autoimmune disease, 3 chronic lymphocytic leukemias, and 1 breast carcinoma.	21228370
Specialty Type - cancer	Stem Cell Exhaustion	CD133 is one of the most representative cancer stem cell markers.	21228926
Mucopolysaccharidosis I	Stem Cell Exhaustion	In seven patients, five with MPS I-H treated with stem cell transplantation (SCT), and two with MPS VI, one treated with SCT and the other with enzyme therapy, the IOP was examined with ORA.	21232085
Hemopoietic stem cell transplant, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Pre-transplant consolidation chemotherapy may not improve outcomes after reduced intensity conditioning hematopoietic stem cell transplantation for acute myeloid leukemia in first complete remission.	21232793
Hollings Cancer Center	Stem Cell Exhaustion	In particular, a stem cell marker EpCAM was dominantly expressed in CM-type HCC.	21233610
Specialty Type - cancer	Stem Cell Exhaustion	These were the cancer cell-, the microenvironment- and the stem cell-specific gene groups.	21234521
Liver carcinoma	Stem Cell Exhaustion	Immunohistochemical study of hepatocyte, cholangiocyte and stem cell markers of hepatocellular carcinoma.	21234612
Hollings Cancer Center	Stem Cell Exhaustion	At the same time, the expression of stem/progenitor cell markers and cholangiocyte markers may also indicate de-differentiation and transdifferentiation of ordinary HCC cells.	21234612
Hollings Cancer Center	Stem Cell Exhaustion	Sixty-eight surgically resected HCC lesions no larger than 5 cm were studied immunohistochemically using a hepatocyte marker (Hepatocyte), 2 cholangiocyte markers (cytokeratins CK7 and CK19), a marker for mucin (Muc1), and a hepatic stem/progenitor cell marker (C-kit).	21234612
Hollings Cancer Center	Stem Cell Exhaustion	The positivity of cholangiocyte markers, the stem/progenitor cell marker and mucin production were thought to be due to transdifferentiation of HCC cells rather than malignant transformation of stem/progenitor cells.	21234612
TG wt Allele	Stem Cell Exhaustion	Positive staining for bcl-2 and p63, and negative staining for PTH, CT, and TG in SCN main cells are both consistent with the widely accepted minimalist definition of stem cells, thus supporting the hypothesis that they may play a stem cell role in the thyroid gland, although further research will be required into stem cell markers.	21234707
insensitivity	Stem Cell Exhaustion	The impact of inflammatory mediators, EPO insensitivity, and other factors that may act on the hematopoietic stem cell to decrease erythropoiesis are under active study and should serve to elucidate the pathophysiology of this important cause of morbidity and mortality in elderly individuals.	21239805
Membranoproliferative Glomerulonephritis, Type II	Stem Cell Exhaustion	Marked improvement by high-dose chemotherapy and autologous stem cell transplantation in a case of light chain deposition disease.	21240874
Proteinuria	Stem Cell Exhaustion	Proteinuria disappeared and renal function stabilized after high-dose chemotherapy and autologous stem cell transplantation.	21240874
Membranoproliferative Glomerulonephritis, Type II	Stem Cell Exhaustion	It appears that an early initiation of active therapy such as high-dose chemotherapy and autologous stem cell transplantation may be beneficial for patients with light chain deposition disease.	21240874
Dyskeratosis Congenita	Stem Cell Exhaustion	Accelerated hematopoietic stem cell aging in a mouse model of dyskeratosis congenita responds to antioxidant treatment.	21241452
Ischemia	Stem Cell Exhaustion	Combination stem cell therapy for the treatment of medically refractory coronary ischemia: a Phase I study.	21241969
Ischemia	Stem Cell Exhaustion	Infusion of a source of endothelial progenitor cells (EPC) into the ischemic myocardium is emerging as a promising therapy for coronary ischemia, probably mediated by the formation of new blood vessels.	21241969
Congenital heart disease	Stem Cell Exhaustion	Characterization and functionality of cardiac progenitor cells in congenital heart patients.	21242485
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Pralatrexate induced durable responses in relapsed or refractory PTCL irrespective of age, histologic subtypes, amount of prior therapy, prior methotrexate, and prior autologous stem-cell transplant.	21245435
Age related macular degeneration	Stem Cell Exhaustion	SU5416 induces premature senescence in endothelial progenitor cells from patients with age-related macular degeneration.	21245959
Encephalitis, St. Louis, Calcification of coronary artery	Stem Cell Exhaustion	Circulating endothelial progenitor cells are reduced in SLE in the absence of coronary artery calcification.	21246370
Lupus Erythematosus, Systemic, Encephalitis, St. Louis	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPCs) are reduced in patients with systemic lupus erythematosus (SLE).	21246370
Esophageal Neoplasms	Stem Cell Exhaustion	To determine the relationship between resistance to chemotherapy and microRNA (miRNA) expression in esophageal cancer, we focused on miRNAs known to be associated with maintenance of stem cell function.	21248297
Esophageal Neoplasms	Stem Cell Exhaustion	Using 98 formalin-fixed, paraffin-embedded samples obtained from patients with esophageal cancer who had received preoperative chemotherapy followed by surgery, we measured expression levels of several miRNAs that are considered to be involved in the regulation of stem cell function (e.g., let-7a, let-7g, miR-21, miR-134, miR-145, miR-155, miR-200c, miR-203, and miR-296) by real-time reverse transcriptase PCR.	21248297
Dermatofibrosarcoma Protuberans, Cutaneous Fibrous Histiocytoma	Stem Cell Exhaustion	Expression of embryonic stem cell markers SOX2 and nestin in dermatofibrosarcoma protuberans and dermatofibroma.	21251041
Giant Cell Fibroblastoma	Stem Cell Exhaustion	Dermatofibrosarcoma protuberans (DFSP) was recently proposed to originate from a nestin-positive stem cell.	21251041
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia.	21251617
T-Cell Lymphoma, Mycosis Fungoides and Sezary Syndrome	Stem Cell Exhaustion	A large single-center experience with allogeneic stem-cell transplantation for peripheral T-cell non-Hodgkin lymphoma and advanced mycosis fungoides/Sezary syndrome.	21252059
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Effects of pioglitazone versus metformin on circulating endothelial microparticles and progenitor cells in patients with newly diagnosed type 2 diabetes--a randomized controlled trial.	21255215
Endothelium	Stem Cell Exhaustion	Endothelial microparticles (EMPs) and endothelial progenitor cells (EPCs) are markers of endothelial injury and repair.	21255215
Cerebrovascular accident	Stem Cell Exhaustion	Plasma VEGF, SDF-1a, granulocyte colony-stimulating factor, and stem cell factor were determined by enzyme-linked immunosorbent assay on days 1 and 3, and brain MRI was performed at baseline and on days 1 and 5 after the stroke onset.	21257825
Ischemic stroke	Stem Cell Exhaustion	These results indicate that SDF-1a and stem cell factor correlate with an increase in EPC early in ischemic stroke patients.	21257825
Cerebrovascular accident	Stem Cell Exhaustion	Stromal-derived factor-1[alpha] correlates with circulating endothelial progenitor cells and with acute lesion volume in stroke patients.	21257825
Chronic graft-versus-host disease	Stem Cell Exhaustion	Association between serum high-molecular-weight adiponectin level and the severity of chronic graft-versus-host disease in allogeneic stem cell transplantation recipients.	21258011
Intestinal Perforation, Lymphoproliferative Disorders	Stem Cell Exhaustion	[Epstein-Barr virus-associated post-transplant lymphoproliferative disorder diagnosed by the episode of intestinal perforation following allogeneic hematopoietic stem cell transplantation].	21258188
Post-transplant lymphoproliferative disorder, Gastrointestinal perforation	Stem Cell Exhaustion	PTLD after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is relatively rare, and the development of gastrointestinal perforation after allo-HSCT is very rare.	21258188
Lymphoma	Stem Cell Exhaustion	We identified 496 consecutive individuals with lymphoma who underwent hematopoietic stem cell mobilization using etoposide and G-CSF and first autologous transplantation.	21258422
Malignant Hypertension, Hypertension, CTCAE	Stem Cell Exhaustion	We measured flow (hyperemia)-mediated dilation and response to glyceryl trinitrate of brachial artery (ultrasound), microvascular (forearm) response to acetylcholine and sodium nitroprusside (laser Doppler), pulse wave velocity, circulating endothelial and endothelial progenitor cells in 15 patients with malignant hypertension, 40 matched patients with hypertension, and 40 healthy controls.	21263115
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft versus host disease (GVHD) represents one of the major limiting factors to the successful applicability of hematopoietic stem cells transplantation (HSCT).	21264911
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A modified EBMT risk score predicts the outcome of patients with acute myeloid leukemia receiving allogeneic stem cell transplants.	21265883
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	To investigate the capacity of a modified European group for blood and marrow transplantation (mEBMT) risk score to predict the outcome of patients with acute myeloid leukemia (AML) receiving allogeneic stem cell transplants, we retrospectively analyzed 214 patients transplanted at our center between 1995 and 2008.	21265883
Malignant neoplasm of stomach	Stem Cell Exhaustion	Polymorphisms in prostate stem cell antigen gene rs2294008 increase gastric cancer risk in Chinese.	21268123
Ovarian Teratoma, Teratoma	Stem Cell Exhaustion	To understand the molecular mechanisms of ovarian teratoma growth, a comparative proteomic analysis was undertaken using mesenchymal stem cell-like cells (MSCLCs) isolated from normal human ovarian or teratoma tissues.	21268265
Glioblastoma	Stem Cell Exhaustion	The presence of stem cell marker-expressing cells is not prognostically significant in glioblastomas.	21269333
Adult Glioblastoma, Specialty Type - cancer	Stem Cell Exhaustion	To evaluate the prognostic implication of cancer stem cell markers in glioblastoma, the expression of these markers was investigated in a large series of glioblastoma patients in relation to the survival rate.	21269333
Glioblastoma Multiforme Pathway, Adult Glioblastoma	Stem Cell Exhaustion	Although the correlation of stem cell marker expression with clinical outcome in glioma is of considerable interest, the data do not support their prognostic value in glioblastoma.	21269333
Ischemic stroke	Stem Cell Exhaustion	Effect of erythropoietin on level of circulating endothelial progenitor cells and outcome in patients after acute ischemic stroke.	21269484
Ischemic stroke	Stem Cell Exhaustion	Erythropoietin (EPO) enhances the circulating level of endothelial progenitor cells (EPCs), which has been reported to be associated with prognostic outcome in ischemic stroke (IS) patients.	21269484
Colorectal Neoplasms	Stem Cell Exhaustion	Expression of LGR5, an intestinal stem cell marker, during each stage of colorectal tumorigenesis.	21273608
Glioma	Stem Cell Exhaustion	Recent studies suggest a possible origin of human gliomas from subventricular zone (SVZ) stem cells.	21273932
Myeloproliferative disease	Stem Cell Exhaustion	It is a chronic clonal myeloproliferative disorder, originating in a pluripotent stem cell common to all three hematopoietic lineages, characterized by overproduction of myeloid cells in all stages of maturation.	21273957
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Treatment options for patients with high-risk acute myeloid leukemia (AML) include high-dose chemotherapy regimens in combination with allogeneic hematopoietic stem cell transplantation, which takes advantage of the donor T-cell-mediated graft-versus-leukemia effect.	21274712
Fanconi Anemia	Stem Cell Exhaustion	A 14-year-old girl with Fanconi anemia was submitted to allogeneic hematopoietic stem cell transplantation.	21276065
Breast Carcinoma	Stem Cell Exhaustion	Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma.	21276239
Postmenopausal state	Stem Cell Exhaustion	In this report, we show that the embryonic stem cell factor SOX2 is expressed in a variety of early stage postmenopausal breast carcinomas and metastatic lymph nodes.	21276239
Neoplasms	Stem Cell Exhaustion	Serum samples for PK or whole blood for the evaluation of circulating tumor cells, endothelial cells, and endothelial progenitor cells were obtained on Days 1, 8, 15, 29, and 50.	21276608
Hollings Cancer Center	Stem Cell Exhaustion	A decreased serum stem cell-derived factor-1 level 1 month after RT completion was a significant predictor of the overall survival of HCC patients receiving RT.	21277098
Aplastic Anemia, CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology	Stem Cell Exhaustion	Immunosuppressive therapy (IST) with anti-thymocyte globulin (ATG) plus cyclosporine A (CsA) is the standard treatment for aplastic anemia (AA) patients not eligible for allogeneic hematopoietic stem cell transplantation (HSCT).	21279356
Uveal melanoma, Stem Cell Factor	Stem Cell Exhaustion	To evaluate the concurrent rate of expression of c-Kit and its ligand stem cell factor (SCF) in uveal melanoma in respect to the further clinical course and the correlation of these markers.	21279973
Globoid cell leukodystrophy	Stem Cell Exhaustion	Mesenchymal lineage stem cells have pronounced anti-inflammatory effects in the twitcher mouse model of Krabbe's disease.	21280158
Inflammation	Stem Cell Exhaustion	These data indicate that mesenchymal lineage stem cells are potent inhibitors of inflammation associated with KD progression and offer potential benefits as a component of a combination approach for in vivo treatment by reducing the levels of inflammation.	21280158
Pterygium	Stem Cell Exhaustion	Ophthalmic pterygium: a stem cell disorder with premalignant features.	21281814
leukemia	Stem Cell Exhaustion	TRAIL-R3 expression was also high on CD34+/CD38- cells, the compartment that harbors the leukemia initiating stem cell.	21281967
Schistocyte	Stem Cell Exhaustion	Observation of schistocytes on the peripheral blood following haematopoietic stem cell transplantation (SCT) is a common finding.	21284831
Gastrointestinal Stromal Tumors, Mesenchymal Cell Neoplasm	Stem Cell Exhaustion	Gastrointestinal stromal tumors (GIST) are mesenchymal tumors of the gastrointestinal tract, usually kit-positive, that are believed to originate from interstitial cell of Cajal, or their related stem cells.	21284869
Lymphoma, Non-Hodgkin, Multiple Myeloma	Stem Cell Exhaustion	Several studies in adults have shown plerixafor to be effective for the mobilization of hematopoietic stem cells when used in combination with G-CSF in adults with non-Hodgkin's lymphoma and multiple myeloma who failed to mobilize sufficient CD34+ cells with G-CSF alone.	21285407
Myeloid	Stem Cell Exhaustion	Evi1 (ecotropic viral integration site 1) is essential for proliferation of hematopoietic stem cells and implicated in the development of myeloid disorders.	21289308
Chronic heart failure	Stem Cell Exhaustion	The effect of acute exercise on endothelial progenitor cells is attenuated in chronic heart failure.	21290145
Chronic heart failure, Congestive heart failure	Stem Cell Exhaustion	Exercise training improves endothelial function in patients with chronic heart failure (CHF) through functional enhancement of circulating angiogenic cells and increased numbers of circulating endothelial progenitor cells (EPC).	21290145
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	The findings from this case have both diagnostic and biological implications that may inspire future studies on the pathogenic mechanisms by which cancer stem cells assume aberrant differentiation programs and the molecular switch(es) that initiates trophoblastic differentiation in adult tumor tissues.	21293290
Neoplasms, Secondary Neoplasm, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology	Stem Cell Exhaustion	MicroRNA-200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells.	21294122
Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology	Stem Cell Exhaustion	However, the role of miR200c in head and neck squamous cell carcinoma (HNSCC) and HNSCC-associated cancer stem cells (HNSCC-CSCs) is unknown.	21294122
Specialty Type - cancer	Stem Cell Exhaustion	This has the potential to be a powerful adjunct to stem-cell and cancer research.	21294632
Central neuroblastoma	Stem Cell Exhaustion	Patients were included when they fulfilled all of the following criteria: Age at diagnosis being 1 year or older, first diagnosis between 1990 and 2007, stage 4 disease or stage 3 neuroblastoma with MYCN amplification, and relapse or progression after successful first-line autologous stem cell transplantation (ASCT).	21298742
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Nineteen patients had acute myeloid leukaemia and 47 had received high-dose chemotherapy supported by autologous stem cell transplant.	21299364
Pneumocystis jiroveci	Stem Cell Exhaustion	Pneumocystis jirovecii prophylaxis is standard in allogeneic stem cell transplantation (alloSCT), sometimes with pentamidine at a low dose inhaled monthly.	21299635
Russell-Silver syndrome	Stem Cell Exhaustion	Repeat SRS is promising to preserve neurocognition, because the convergent dose distribution decreases the unfavorable influences from radiation on germinal niches, thereby preserving neural stem cells that are responsible for the nervous system repair.	21301184
leukemia	Stem Cell Exhaustion	In this clonal disorder possibly involving a pluripotent hematopoietic stem cell, we postulate that the well documented relationships between PDGFRA downstream signals and intracellular ROS levels might influence the phenotype of this leukemia.	21302907
Malignant Neoplasms	Stem Cell Exhaustion	Common underlying conditions were hematopoietic stem cell and other transplantations (26.1%), malignancies (20.8%) and HIV (32.9%).	21306282
Childhood Breast Carcinoma, Neoplasms	Stem Cell Exhaustion	In this study, to explore putative breast cancer stem cells with CD44+CD24- in the SLN, we retrospectively analyzed the expression of CD44+CD24- on metastatic tumor cells within SLNs as a predictive factor for positive non-SLNs (NSLNs).	21308353
Deficiency	Stem Cell Exhaustion	Telomere shortening owing to telomerase deficiency leads to accelerated senescence of human skeletal (mesenchymal) stem cells (MSCs) in vitro, whereas overexpression leads to telomere elongation, extended life span, and enhanced bone formation.	21308778
Gastrointestinal mucositis	Stem Cell Exhaustion	The risk factors for oral mucositis and the effect of cryotherapy in patients after the BEAM and HD-l-PAM 200 mg/m(2) autologous hematopoietic stem cell transplantation.	21310656
Gastrointestinal mucositis	Stem Cell Exhaustion	Oral mucositis (OM) still represents a significant complication of hematopoietic stem cell transplantations (HSCT).	21310656
Multiple Myeloma	Stem Cell Exhaustion	Infusional mitoxantrone plus bolus melphalan as a stem cell transplant conditioning regimen for multiple myeloma.	21314330
Peripheral Blood Stem Cells, Mantle cell lymphoma	Stem Cell Exhaustion	To address whether treatment with hyper-CVAD impairs mobilization of peripheral blood stem cells, we retrospectively analyzed mobilization data from 77 consecutive adult patients with mantle cell lymphoma who underwent peripheral blood stem cell (PBSC) mobilization for planned autologous stem cell transplant (ASCT).	21314484
Mantle cell lymphoma	Stem Cell Exhaustion	Treatment with hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone combined with cytarabine and methotrexate results in poor mobilization of peripheral blood stem cells in patients with mantle cell lymphoma.	21314484
Ovarian Carcinoma	Stem Cell Exhaustion	The objective of this study was to analyze the clinical role of nestin, a stem cell marker, and class III b-tubulin in advanced-stage serous ovarian carcinoma.	21315408
Injury of kidney	Stem Cell Exhaustion	Animal studies indicate that adult renal stem/progenitor cells can undergo rapid proliferation in response to renal injury, but whether the same is true in humans is largely unknown.	21315412
Acute Kidney Tubular Necrosis	Stem Cell Exhaustion	To examine the profile of renal stem/progenitor cells responsible for acute tubular necrosis in human kidney, double and triple immunostaining was performed using proliferative marker and stem/progenitor protein markers on sections from 10 kidneys with acute tubular necrosis and 4 normal adult kidneys.	21315412
Acute Kidney Tubular Necrosis	Stem Cell Exhaustion	Our data suggest that renal stem/progenitor cells may reside not only in the parietal layer of Bowman capsule but also in the cortex and medulla in normal human kidney, and the proliferative capacity of renal stem/progenitor cells after acute tubular necrosis may be an important determinant of a patient's outcome.	21315412
Childhood Breast Carcinoma	Stem Cell Exhaustion	The number of circulating CD34(+) (hematopoietic stem) cells (HSCs) was observed to decline by 15% in breast cancer patients after starting adjuvant radiation therapy, regardless of age or preceding chemotherapy.	21316784
Pancytopenia, Acquired aplastic anemia, Hematological Disease	Stem Cell Exhaustion	Acquired aplastic anemia is a rare hematopoietic stem-cell disorder that results in pancytopenia and hypocellular bone marrow.	21319000
Acquired aplastic anemia	Stem Cell Exhaustion	Acquired aplastic anemia can now be cured or ameliorated by stem-cell transplantation or immunosuppressive drug therapy such as antithymocyte globulin or cyclosporine.	21319000
Liver Cirrhosis	Stem Cell Exhaustion	Proliferating cell nuclear antigen (proliferation marker) and p21 (senescence marker) were both higher in hepatocytes in cirrhosis than in normal livers, but ductular reaction hepatobiliary cells had the highest proliferation rate, in keeping with being stem/progenitor cell-derived transit amplifying cells.	21319194
Hepatitis A, Hepatobiliary System	Stem Cell Exhaustion	These morphologic, topographic, immunophenotypic, and molecular data support the concept that EpCAM(+) hepatocytes in chronic viral hepatitis are recent progeny of the hepatobiliary stem/progenitor cell compartment through intermediates of the transit amplifying, ductular reaction hepatobiliary cells.	21319194
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Allogeneic stem-cell transplantation as salvage therapy for patients with diffuse large B-cell non-Hodgkin's lymphoma relapsing after an autologous stem-cell transplantation: an analysis of the European Group for Blood and Marrow Transplantation Registry.	21321299
Lymphoma, Non-Hodgkin, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	To analyze the outcome, including nonrelapse mortality (NRM), relapse rate (RR), progression-free survival (PFS), and overall survival (OS), of patients with diffuse large B-cell non-Hodgkin's lymphoma (DLBCL) relapsed after an autologous stem-cell transplantation (ASCT) and treated with an allogeneic stem-cell transplantation (allo-SCT).	21321299
palladium	Stem Cell Exhaustion	We have investigated the effects of commonly used treatments for PD on neural stem cell (NSC) activity in nondemented patients.	21322018
Neutropenia, Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Pegfilgrastim to accelerate neutrophil engraftment following peripheral blood stem cell transplant and reduce the duration of neutropenia, hospitalization, and use of intravenous antibiotics: a phase II study in multiple myeloma and lymphoma and comparison with filgrastim-treated matched controls.	21323524
Fusariosis, Endophthalmitis	Stem Cell Exhaustion	Endophthalmitis as primary clinical manifestation of fatal fusariosis in an allogeneic stem cell recipient.	21324055
Fever, Endophthalmitis, Myalgia	Stem Cell Exhaustion	Here, we report the case of a patient presenting with fever, muscle pain, and bilateral endophthalmitis after allogeneic hematopoietic stem cell transplantation.	21324055
Hematologic Neoplasms	Stem Cell Exhaustion	Seroconversion rates following influenza vaccination in patients with hematologic malignancies after hematopoietic stem cell transplantation (HSCT) are known to be lower compared to healthy adults.	21324375
Dominica	Stem Cell Exhaustion	We aimed to investigate the cross-sectional association of Vit-D status with brachial flow-mediated dilation (FMD) and circulating endothelial progenitor cell (EPC) numbers in type 2 DM patients.	21325459
Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes.	21325459
Endothelial dysfunction, Deficiency	Stem Cell Exhaustion	The relationship of Vit-D deficiency with circulating endothelial progenitor cells and endothelial dysfunction in type 2 DM patients nonetheless remains unclear.	21325459
Heart failure	Stem Cell Exhaustion	Repeated intracoronary infusion of peripheral blood stem cells with G-CSF in patients with refractory ischemic heart failure--a pilot study.	21325723
Electrocardiogram: myocardial infarction (finding), Congestive heart failure	Stem Cell Exhaustion	Recent investigations have suggested the clinical efficacy of granulocyte colony-stimulating factor (G-CSF) infusion alone or in combination with a single dose delivery of peripheral blood stem cells (PBSC) infusion in patients with myocardial infarction (MI) and congestive heart failure (HF).	21325723
Hematologic Neoplasms, Herpesviridae Infections	Stem Cell Exhaustion	Herpesviridae viral infections (HVIs) are particularly common in patients with hematologic malignancies after undergoing hematopoietic stem cell transplantation or receiving chemotherapy.	21325812
Hemorrhagic cystitis	Stem Cell Exhaustion	BK-virus-associated hemorrhagic cystitis in children after hematopoietic stem cell transplantation.	21325972
Hemorrhagic cystitis	Stem Cell Exhaustion	BK-virus-induced hemorrhagic cystitis (BK-HC) is a serious complication in children undergoing hematopoietic stem cell transplantation (HSCT).	21325972
leukemia	Stem Cell Exhaustion	We conducted a retrospective study assessing the predictive value of early full donor chimerism status for relapse after allogeneic peripheral blood progenitor cell transplantation in 40 children aged between 1 and 16 years (median 8) with leukemia.	21325973
Neoplasms	Stem Cell Exhaustion	These cases demonstrate the capacity of tumor cells to differentiate into divergent elements, supporting the concept of pluripotent tumor stem cells.	21326817
Liver Cirrhosis	Stem Cell Exhaustion	Transplanted human amniotic membrane-derived mesenchymal stem cells ameliorate carbon tetrachloride-induced liver cirrhosis in mouse.	21326862
Fibrosis, Liver, Pulmonary Fibrosis	Stem Cell Exhaustion	Human amniotic membrane-derived mesenchymal stem cells (hAMCs) have the potential to reduce heart and lung fibrosis, but whether could reduce liver fibrosis remains largely unknown.	21326862
Tumor necrosis	Stem Cell Exhaustion	Human dermally-derived stem cells (FmSCs) were exposed to the cytokines interleukin-6 (IL-6), IL-1b, and tumor necrosis factor-a (TNF-a) in the presence of erythropoietin (EPO).	21329452
Cardiomyopathies	Stem Cell Exhaustion	Functionally competent cardiac stem cells can be isolated from endomyocardial biopsies of patients with advanced cardiomyopathies.	21330601
Malignant neoplasm of stomach, Specialty Type - cancer	Stem Cell Exhaustion	Recently, the CD44 molecule was reported to be a marker of cancer stem cells in gastric cancer.	21331451
Intimal proliferation	Stem Cell Exhaustion	Differentiation profile of peripheral blood-derived vascular progenitor cell predicts intimal hyperplasia after coronary stenting.	21331618
Liver carcinoma	Stem Cell Exhaustion	Elevated expression of the stem cell marker CD133 associated with Line-1 demethylation in hepatocellular carcinoma.	21331808
Liver carcinoma, Specialty Type - cancer, Hollings Cancer Center	Stem Cell Exhaustion	The relationship of Line-1 demethylation and the CD133 expression of cancer stem cells were discussed in hepatocellular carcinoma (HCC).	21331808
Hematologic Neoplasms	Stem Cell Exhaustion	A randomized clinical trial comparing granulocyte-colony-stimulating factor administration sites for mobilization of peripheral blood stem cells for patients with hematologic malignancies undergoing autologous stem cell transplantation.	21332729
Multiple Myeloma	Stem Cell Exhaustion	We completed a prospective randomized study to determine the efficacy and tolerability of different injection sites for patients with multiple myeloma or lymphoma undergoing stem cell mobilization and apheresis.	21332729
Specialty Type - cancer, Primary malignant neoplasm	Stem Cell Exhaustion	Primary breast cancer patients with high risk clinicopathologic features have high percentages of bone marrow epithelial cells with ALDH activity and CD44+CD24lo cancer stem cell phenotype.	21334874
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSCs) are purported to be epithelial tumour cells expressing CD44(+)CD24(lo) that exhibit aldehyde dehydrogenase activity (Aldefluor(+)).	21334874
Multiple Myeloma	Stem Cell Exhaustion	Mobilization and collection of peripheral blood stem cells in multiple myeloma patients older than 65 years.	21335198
B-Cell Lymphomas, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	This phase II trial evaluated the efficacy and safety of tandem consolidation using (90)yttrium ibritumomab tiuxetan ((90)Y-IT) and high-dose therapy (HDT) with autologous peripheral blood stem cell transplantation (PBSCT) in high-risk patients with diffuse large B-cell lymphoma (DLBCL) who were in primary remission.	21336624
Febrile Neutropenia, Infection, Acute leukemia	Stem Cell Exhaustion	Objective of the present study was to describe the profile of infections in febrile neutropenia (FN) in acute leukemia and hematopoietic stem cell transplant (HSCT) with emphasis on response to therapy and outcome.	21336987
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	busulfan-fludarabine and allogeneic hematopoietic stem cell transplant for patients with acute myeloid leukemia or myelodysplastic syndrome in the sixth through eighth decades of life.	21338705
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	b-catenin was found upregulated in the vast majority of AML samples and more frequently localized in the nucleus of leukemic stem cells compared with normal bone marrow CD34(+) cells.	21339756
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Factors predicting outcome after unrelated donor stem cell transplantation in primary refractory acute myeloid leukaemia.	21339758
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Some studies have shown that OCT4 is expressed in adult stem cells, somatic cancers and, further, cancer stem cells, while other studies failed to make such an observation.	21341266
Glioblastoma Multiforme Pathway, Breast Carcinoma, Solid Neoplasm, Specialty Type - cancer	Stem Cell Exhaustion	OCT4-pg1, OCT4-pg3 and OCT4-pg4 but excluding the OCT4 gene, were found to be expressed in two types of human solid tumours, glioma and breast carcinoma, from which cancer stem cells had earlier been isolated.	21341266
Malignant Neoplasms	Stem Cell Exhaustion	Hence, in investigations of OCT4 expression in cancers and stem cells, different approaches with appropriate controls would be desirable to exclude possibility of false-positive results.	21341266
Specialty Type - cancer, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Cancer stem cells (CSC) model theoretically contribute to tumor growth, metastasis, and chemo-radioresistance.	21342274
Bone marrow hypocellularity, Aplastic Anemia	Stem Cell Exhaustion	In addition, they suggest that human marrow failure, such as the marrow failure that occurs after umbilical cord blood transplantation and with aplastic anemia, results from insufficient numbers of early progenitor cells, and not the absence of HSCs.	21343613
Malignant Neoplasms	Stem Cell Exhaustion	They exhibited immunohistochemical features of hepatic progenitor cells, i.e., expressing CK7, CK19, and N-CAM; and their malignancy was supported by the p53 and Ki67 immunoreactivity.	21344355
Cholangiolocellular Carcinoma, Hepatitis B, Chronic, Liver carcinoma, Cholangiocarcinoma	Stem Cell Exhaustion	Cholangiolocellular carcinoma has been reported to be associated with chronic hepatitis C viral infection and to derive from hepatic progenitor cells, which explains why hepatocellular carcinoma and/or cholangiocarcinoma component may be present.	21344355
South Ndebele language	Stem Cell Exhaustion	Unfortunately the prognosis for patients within the high-risk group accounting for more than 50% of all NBL patients remains poor despite the introduction of more intensive chemotherapy regimens with radical surgery procedures and megachemotherapy with subsequent stem cell transplantation.	21344767
Acute monoblastic leukemia	Stem Cell Exhaustion	[Complete autologous bone marrow recovery after allogeneic stem cell transplantation in a child with acute monoblastic leukemia].	21344774
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We present a case of autologous bone marrow recovery after allogeneic hematopoietic stem cell transplantation (HSCT) in a 7-year old girl who was treated due to acute myelocytic leukemia.	21344774
Ki-1+ Anaplastic Large Cell Lymphoma	Stem Cell Exhaustion	Patient with ALCL was treated with chemotherapy and allogeneic stem cell transplantation.	21344776
Barrett Esophagus, Specialty Type - cancer, Adenocarcinoma Of Esophagus	Stem Cell Exhaustion	LgR5 expression and cancer stem cell hypothesis: clue to define the true origin of esophageal adenocarcinomas with and without Barrett's esophagus?	21345220
Barrett Esophagus, Specialty Type - cancer, Adenocarcinoma Of Esophagus	Stem Cell Exhaustion	Investigation of the expression of an intestinal stem cell marker in esophageal adenocarcinomas (EAC) with and without Barrett's Esophagus (BE), with respect to a cancer stem cell (CSC) hypothesis.	21345220
Extrapulmonary Small Cell Carcinoma, Adenocarcinoma, Squamous cell carcinoma of esophagus, Esophageal Neoplasms	Stem Cell Exhaustion	Expression of a putative intestinal stem cell marker LgR5 was analyzed in esophageal cancer specimen (n = 70: 41 EAC with BE, 19 EAC without BE, and n = 10 esophageal squamous-cell carcinomas, ESCC) and in the adenocarcinoma cell line OE-33.	21345220
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	New data suggest that glioma stem-like cells (GSCs) and neural stem/progenitor cells (NSCs) may share common origins.	21346220
LMNA wt Allele	Stem Cell Exhaustion	Here we report the generation of induced pluripotent stem cells (iPSCs) from fibroblasts obtained from patients with HGPS.	21346760
Multiple Myeloma	Stem Cell Exhaustion	The place of allogeneic stem cell transplantation in the treatment of myeloma remains controversial.	21349768
EBV-Related Lymphoproliferative Disorder	Stem Cell Exhaustion	This single centre study assessed the incidence, kinetics and predictive factors of Epstein-Barr Virus (EBV) reactivation and EBV-related lymphoproliferative diseases (LPDs) in 175 consecutive patients who received a reduced-intensity conditioning (RIC) before allogeneic hematopoietic stem cell transplantation (allo-HSCT).	21350556
Trichoepithelioma, Experimental Organism Basal Cell Carcinoma	Stem Cell Exhaustion	Follicular stem cell marker PHLDA1 (TDAG51) is superior to cytokeratin-20 in differentiating between trichoepithelioma and basal cell carcinoma in small biopsy specimens.	21352265
Specialty Type - cancer	Stem Cell Exhaustion	Additionally, we explored the function of Skp2 in maintaining a cancer stem cell-like phenotype in NPC cell lines.	21352698
Specialty Type - cancer	Stem Cell Exhaustion	Skp2 may play a role in maintaining the cancer stem cell-like phenotype of NPC cell lines.	21352698
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Impaired endothelial progenitor cell mobilization and colony-forming capacity in chronic obstructive pulmonary disease.	21355963
Hematologic Neoplasms	Stem Cell Exhaustion	Using a case-control study with activity-based costing of patients admitted to a quaternary hospital from 2002 to 2007, we determined attributable hospitalization cost (and 12 weeks thereafter), length of stay (LOS), and costly antifungal treatment (C-AT; liposomal amphotericin B, voriconazole, posaconazole, caspofungin), expressed as defined daily doses (DDDs) per IFD episode, in patients with hematological malignancies and hematopoietic stem cell recipients.	21357302
Primary malignant neoplasm	Stem Cell Exhaustion	We explored the possible correlation between bone marrow mesenchymal stem cells (BM-MSC) and disseminated breast cancer-initiating cells (BCIC) in primary breast cancer patients.	21358274
Primary malignant neoplasm	Stem Cell Exhaustion	There was a positive correlation between mesenchymal stem cells expressing GD2 and CD271 and breast cancer-initiating cells in BM of patients with primary breast cancer.	21358274
Rhizomucor pusillus, Aplastic Anemia, Multiple Organ Failure	Stem Cell Exhaustion	Disseminated Rhizomucor pusillus causing early multiorgan failure during hematopoietic stem cell transplantation for severe aplastic anemia.	21358340
Aplastic Anemia	Stem Cell Exhaustion	Matched sibling donor hematopoietic stem cell transplantation is the standard of care for severe aplastic anemia, with an overall survival of 80% to 90%.	21358340
Aplastic Anemia, Multiple Organ Failure	Stem Cell Exhaustion	A 10-year-old patient with severe aplastic anemia underwent matched sibling donor hematopoietic stem cell transplantation, but developed sudden onset of fatal multiorgan failure on day +12.	21358340
Autoimmune Diseases, Aplastic Anemia	Stem Cell Exhaustion	High-dose cyclophosphamide without stem cell rescue in 207 patients with aplastic anemia and other autoimmune diseases.	21358440
Autoimmune Diseases, Aplastic Anemia	Stem Cell Exhaustion	High-dose cyclophosphamide has long been used as an anticancer agent, a conditioning regimen for hematopoietic stem cell transplantation, and a potent immunosuppressive agent in autoimmune diseases including aplastic anemia.	21358440
Autoimmune Diseases	Stem Cell Exhaustion	Moreover, high-dose cyclophosphamide without hematopoietic stem cell rescue has shown activity in a variety of other severe autoimmune diseases.	21358440
Autoimmune Diseases	Stem Cell Exhaustion	This latter component was designed to assess the safety and efficacy of high-dose cyclophosphamide therapy without stem cell rescue in patients with refractory autoimmune diseases.	21358440
Autoimmune Diseases	Stem Cell Exhaustion	High-dose cyclophosphamide without stem cell rescue is well tolerated and induces a high rate of remission in severe autoimmune diseases.	21358440
Lymphoma, Non-Hodgkin, Familial, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	The significance of early lymphocyte recovery following a stem cell transplant in NHL subtype diffuse large B-cell lymphoma (DLBCL) in the rituximab era remains unclear.	21358691
Nasal sinus	Stem Cell Exhaustion	Retrospective analysis of paranasal sinusitis in patients receiving hematopoietic stem cell transplantation.	21360008
Nasal sinus, Opportunistic Infections	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) recipients frequently develop opportunistic infections, including paranasal sinusitis.	21360008
diabetic	Stem Cell Exhaustion	Vasculogenic stem cell mobilization and wound recruitment in diabetic patients: increased cell number and intracellular regulatory protein content associated with hyperbaric oxygen therapy.	21362081
Leg Ulcer, Hypoxia, diabetic	Stem Cell Exhaustion	Diabetic patients undergoing hyperbaric oxygen therapies (HBO(2)T) for refractory lower extremity neuropathic ulcers exhibit more than a twofold elevation (p=0.004) in circulating stem cells after treatments and the post-HBO(2)T CD34(+) cell population contains two- to threefold higher levels of hypoxia inducible factors-1, -2, and -3, as well as thioredoxin-1 (p<0.003), than cells present in blood before HBO(2)T. Skin margins obtained from 2-day-old abdominal wounds exhibit higher expression of CD133, CD34, hypoxia inducible factor-1, and Trx-1 vs. margins from refractory lower extremity wounds and expression of these proteins in all wounds is increased due to HBO(2)T (p<0.003).	21362081
Neoplasms	Stem Cell Exhaustion	In conclusion, AITL is characterized by aggressive progress and generally occurs in elderly patients, its clinical prognosis is poor, the large granular lymphocytosis may be an autoimmune response to the tumor cells or originate from tumor stem/progenitor cells.	21362234
Ewings sarcoma, Pneumonia	Stem Cell Exhaustion	A 9-year-old and a 17-year-old male patients affected by metastatic Ewing sarcoma developed an organizing pneumonia after high-dose chemotherapy with autologous peripheral blood stem cell transplantation followed by total-lung irradiation.	21364470
Symptoms, Peripheral Stem Cell Transplantation, "Metastatic Ewings Sarcoma	Stem Cell Exhaustion	For this reason, even if rare, has to be considered in children affected by lung metastatic Ewing sarcoma with persisting pulmonary symptoms after peripheral blood stem cell transplantation and total-lung irradiation.	21364470
herpesvirus 3, human	Stem Cell Exhaustion	Significant risk factors for the development of herpes zoster were post-autologous peripheral blood stem cell transplantation, relapsing patients, ten or more total treatments and the use of two or more regimens.	21368488
Childhood Breast Carcinoma	Stem Cell Exhaustion	Aldehyde dehydrogenase 1 (ALDH1) has been identified as a reliable marker of breast cancer stem cells.	21371077
Malignant Neoplasms	Stem Cell Exhaustion	Other common underlying conditions were hematopoietic stem cell transplantation (33.8%) and hematologic malignancy (29.1%).	21378595
Glioblastoma	Stem Cell Exhaustion	CSF samples from patients with glioblastoma multiforme show elevated Igf2 and stimulate stem cell proliferation in an Igf2-dependent manner.	21382550
Ischemia	Stem Cell Exhaustion	Parathyroid hormone (PTH) revealed a positive action on progenitor cells released from bone marrow, and many mechanisms supported PTH as a tool to improve stem cell-based therapy in experimental models of ischemia.	21383630
Uremia	Stem Cell Exhaustion	In the present study, we investigated, in a cohort of uremic patients, the effect of different levels of PTH on mobilization of progenitor cell populations.	21383630
Hyperparathyroidism	Stem Cell Exhaustion	After 4 months, we demonstrated an increase in endothelial progenitor cell number in 13 patients with secondary hyperparathyroidism that achieved KDOQI targets in PTH levels after pharmacological treatment.	21383630
Multiple Myeloma	Stem Cell Exhaustion	Successful treatment of early relapse of ocular myeloma with bortezomib and steroid after autologous stem cell transplantation.	21384738
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) can prolong remission duration, overall and progression free-survival in multiple myeloma (MM).	21384738
Toxic effect	Stem Cell Exhaustion	We evaluated the IVOx (ifosfamide-etoposide-oxaliplatin) salvage regimen in terms of response rate, toxicity and stem-cell mobilization.	21385169
LIPC gene	Stem Cell Exhaustion	IVOx is a well-tolerated outpatient regimen for relapsed HL, that does not hamper stem-cell mobilization, achieves good response rates and compares favourably with previously published salvage regimens.	21385169
Osteosarcoma, Specialty Type - cancer	Stem Cell Exhaustion	Human primary bone sarcomas contain CD133+ cancer stem cells displaying high tumorigenicity in vivo.	21385990
Specialty Type - cancer	Stem Cell Exhaustion	This study aimed to identify, isolate, and characterize cancer stem cells from human primary sarcomas.	21385990
Osteosarcoma, Specialty Type - cancer	Stem Cell Exhaustion	Our findings show the existence of cancer stem cells in human primary bone sarcomas and highlight CD133 as a pivotal marker for identification of these cells.	21385990
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Levels of circulating CD45(dim)CD34(+)VEGFR2(+) progenitor cells correlate with outcome in metastatic renal cell carcinoma patients treated with tyrosine kinase inhibitors.	21386843
Amyloidosis	Stem Cell Exhaustion	High-dose melphalan and autologous stem cell transplantation (HDM) is an effective treatment for systemic amyloid light chain (AL) amyloidosis but the eligibility criteria exclude many patients with this disorder.	21387097
malignant disease, PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) represents a heterogeneous group of potentially malignant diseases of bone-marrow stem cells.	21387357
Myocardial necrosis, Coronary Arteriosclerosis	Stem Cell Exhaustion	Are endothelial progenitor cells mobilized by myocardial ischemia or myocardial necrosis?	21392766
Electrocardiogram: myocardial infarction (finding), ST segment elevation myocardial infarction	Stem Cell Exhaustion	In ST-elevation myocardial infarction (STEMI) patients, the main stimuli involved in endothelial progenitor cells (EPCs) mobilization are not fully understood.	21392766
Myocardial, Myocardial necrosis, Coronary Arteriosclerosis	Stem Cell Exhaustion	Our data show that EPCs were strongly correlated to extent of myocardial AAR, thus suggesting that progenitor cells mobilization in STEMI develops in response to myocardial ischemia and not to myocardial necrosis.	21392766
Chronic graft-versus-host disease	Stem Cell Exhaustion	This trial evaluated the feasibility and efficacy of the infusion of mesenchymal stem cells expanded using human serum for the treatment of refractory acute or chronic graft-versus-host disease.	21393326
Graft-vs-Host Disease	Stem Cell Exhaustion	In reduced intensity, allogeneic stem cell transplantation from unrelated donors (u-RIST), graft-versus-host disease (GVHD), graft failure, and non-relapse mortality (NRM) are persistent problems.	21394567
Glioblastoma, IDH-Wildtype, Specialty Type - cancer	Stem Cell Exhaustion	Both in U87MG cells and in primary glioblastoma cultures, the chronic administration of RV (100 mM for up to 96 h) decreased the expression of nestin (a brain (cancer) stem cells marker) but increased that of glial acidic fibrillary protein (a mature glial cell marker) and of bIII-tubulin (a neuronal differentiation marker).	21395220
Lymphoproliferative Disorders	Stem Cell Exhaustion	Isolated cerebral manifestation of Epstein-Barr virus-associated post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation: a case of clinical and diagnostic challenges.	21395956
Post-transplant lymphoproliferative disorder, Lymphoproliferative Disorders	Stem Cell Exhaustion	We present the case of a 49-year-old male patient with Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disorder (PTLD) limited to the brain that occurred 6 months after allogeneic hematopoietic stem cell transplantation (HSCT).	21395956
Sepsis, Renal Insufficiency	Stem Cell Exhaustion	The aim of the present study was to analyze the endothelial progenitor cell system in patients suffering from sepsis with acute renal dysfunction.	21396100
Sepsis	Stem Cell Exhaustion	Sepsis significantly affects the endothelial progenitor cell system, as reflected by increased EPC numbers, increased concentrations of proangiogenic mediators, and reduced proliferative capacity of the cells.	21396100
Sepsis, Renal Insufficiency	Stem Cell Exhaustion	Endothelial progenitor cells (EPC) in sepsis with acute renal dysfunction (ARD).	21396100
Specialty Type - cancer, Malignant neoplasm of stomach, Neoplasms	Stem Cell Exhaustion	In this case, the anastomosis site where a gastrectomy for gastric cancer was once performed might be a good niche or microenvironment for cancer cells or tumor stem cells to metastasize to.	21396733
Hematologic Neoplasms	Stem Cell Exhaustion	Patients with hematological malignancies undergoing intensive chemotherapy or hematopoietic stem cell transplantation were randomized to two arms.	21397541
Keratitis	Stem Cell Exhaustion	Management of mustard gas-induced limbal stem cell deficiency and keratitis.	21397949
Ischemia, Dryness of eye	Stem Cell Exhaustion	The symptoms and clinical findings of patients are presented, and medical and surgical interventions to address dry eye, limbal ischemia and limbal stem cell deficiency (LSCD), and corneal involvements are explained.	21397949
Dilated Cardiomyopathy Pathway	Stem Cell Exhaustion	[Usefulness of intracoronary therapy with progenitor cells in patients with dilated cardiomyopathy: Bridge or alternative to heart transplantation?].	21398194
Heart failure, Doctor of Chiropractic, Dilated Cardiomyopathy Pathway	Stem Cell Exhaustion	Some paediatric publications have recently raised the value of intracoronary therapy with autologous bone marrow-derived progenitor cells (APCs) in children with dilated cardiomyopathy (DCM) and heart failure.	21398194
Diabetes Mellitus, Non-Insulin-Dependent, GDC Disease Response Terminology, Vascular Diseases, Diabetic Retinopathy	Stem Cell Exhaustion	To investigate different types of circulating angiopoietic cells, such as vasculogenic circulating progenitor cells (CPCs), endothelial progenitor cells (EPCs), and mature EPCs (matEPCs) in patients with type 2 diabetes mellitus (T2DM), with or without diabetic retinopathy (DR) and with or without macrovascular disease (MVD).	21398276
Infection	Stem Cell Exhaustion	We recently showed that HIV enters multipotent hematopoietic progenitor cells and establishes both active cytotoxic and latent infections that can be reactivated by myeloid differentiation.	21402361
Acute lymphocytic leukemia	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation overcomes the adverse prognostic impact of CD20 expression in acute lymphoblastic leukemia.	21403127
Diabetes	Stem Cell Exhaustion	Recently a considerable number of promising clinical trials have been designed to perform infusion of stem cells by pancreatic arterial intervention to improve the endocrine function of the pancreas for better diabetes control.	21406019
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Autologous stem cell transplantation as a first-line treatment strategy for chronic lymphocytic leukemia: a multicenter, randomized, controlled trial from the SFGM-TC and GFLLC.	21406717
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Long-term responses have been reported after autologous stem cell transplantation (ASCT) for chronic lymphocytic leukemia (CLL).	21406717
Infection	Stem Cell Exhaustion	Limited information is available from developing countries about complications, pattern of infections, and long-term outcome of patients following high-dose chemotherapy (HDCT) and autologous blood stem cell transplantation (ASCT).	21409382
Hemangiosarcoma	Stem Cell Exhaustion	Our study aimed to examine the correlations between 6 immunohistochemical biomarkers-stem cell factor receptor (KIT), platelet-derived growth factor receptor (PDGFR)-a, PDGFR-b, vascular endothelial growth factor receptor (VEGFR)-1, VEGFR-2, and VEGFR-3-and overall survival (OS) in patients with angiosarcomas.	21409488
Hodgkin Disease	Stem Cell Exhaustion	Autologous stem cell transplant for early relapsed/refractory Hodgkin lymphoma: results from two transplant centres.	21410449
Multiple Myeloma	Stem Cell Exhaustion	Haematopoietic stem cell mobilization with plerixafor and G-CSF in patients with multiple myeloma transplanted with autologous stem cells.	21410533
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	A proportion of patients with multiple myeloma (MM) who have already undergone autologous stem cell transplantation (autoSCT) might benefit from a further transplantation.	21410533
macroangiopathy, Diabetes, Corneal Endothelial Cell Loss	Stem Cell Exhaustion	In diabetes, endothelial damage promotes macroangiopathy and endothelial regeneration is impaired, owing to reduced endothelial progenitor cells (EPCs).	21410861
Coronary Arteriosclerosis	Stem Cell Exhaustion	We report the successful use of the Genous endothelial progenitor cell (EPC) capture stent in two patients requiring PCI for significant coronary artery disease prior to lung resection.	21411333
Glioma, Neoplasms	Stem Cell Exhaustion	The putative tumor stem cell marker CD133 is the marker of choice for identifying brain tumor stem cells in gliomas, but the use of different CD133 antibody clones possibly recognizing different CD133 splice variants with epitopes of different glycosylation status confuses the field.	21411810
Influenza due to Influenza A virus subtype H1N1	Stem Cell Exhaustion	Data derived from epidemiologic surveillance adopted at our center in hematologic and stem cell transplant patients during the 2009 influenza A (H1N1)v pandemic are reported.	21411983
Necrosis	Stem Cell Exhaustion	Trials have brought diverse results of bone marrow stem cell treatment in necrotic myocardium.	21414223
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	This substudy from the Autologous Stem Cell Transplantation in Acute Myocardial Infarction trial (ASTAMI) explored global and regional myocardial function after intracoronary injection of autologous mononuclear bone marrow cells (mBMC) in acute anterior wall myocardial infarction treated with percutaneous coronary intervention.	21414223
Cytomegalovirus Infections	Stem Cell Exhaustion	Maribavir prophylaxis for prevention of cytomegalovirus disease in recipients of allogeneic stem-cell transplants: a phase 3, double-blind, placebo-controlled, randomised trial.	21414843
Cytomegalovirus Infections	Stem Cell Exhaustion	Cytomegalovirus disease as a primary endpoint might not be sufficient to show improvements in cytomegalovirus prevention in recipients of allogeneic stem-cell transplants in the setting of pre-emptive antiviral treatment.	21414843
Ischemic cardiomyopathy	Stem Cell Exhaustion	Intramyocardial stem cell injection in patients with ischemic cardiomyopathy: functional recovery and reverse remodeling.	21415390
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	We used cardiac MRI (CMR) in patients with left ventricular (LV) dysfunction related to remote myocardial infarction (MI) to test the hypothesis that bone marrow progenitor cell injection causes functional recovery of scarred myocardium and reverse remodeling.	21415390
Myocardial	Stem Cell Exhaustion	These data suggest that transcatheter, intramyocardial injections of autologous bone marrow progenitor cells improve regional contractility of a chronic myocardial scar, and these changes predict subsequent reverse remodeling.	21415390
Neoplasms	Stem Cell Exhaustion	It is hypothesized that composite tumors arise from a multipotential stem cell with subsequent bidirectional differentiation.	21419473
Neoplasms	Stem Cell Exhaustion	The concordant E-cadherin status in the neuroendocrine and signet ring cell tumor components and the frequent admixture of mucin 5AC+ cells with foveolar differentiation and mucin 2+ cells with intestinal differentiation may support the hypothesis that composite tumors arise from a common stem cell with bilineage or multilineage differentiation.	21419473
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease is the major determinant of humoral responses to the AS03-adjuvanted influenza A/09/H1N1 vaccine in allogeneic hematopoietic stem cell transplant recipients.	21422117
Graft-vs-Host Disease, Gastrointestinal mucositis	Stem Cell Exhaustion	Efficacy of folinic acid in preventing oral mucositis in allogeneic hematopoietic stem cell transplant patients receiving MTX as prophylaxis for GVHD.	21423118
Adult Glioblastoma	Stem Cell Exhaustion	Cancer-initiating or progenitor cells have been described to be the only cell population with tumorigenic capacity in glioblastoma.	21423202
Pterygium	Stem Cell Exhaustion	Recent studies linked pterygium with neoplastic proliferation, as ocular limbic stem cells and p53-protein expression are altered.	21424047
Bronchiolitis Obliterans	Stem Cell Exhaustion	Incidence, risk factors and outcomes of bronchiolitis obliterans after allogeneic stem cell transplantation.	21424350
Bronchiolitis Obliterans, Respiratory complication, bottle - unit dose, Late Onset Disorders	Stem Cell Exhaustion	Bronchiolitis obliterans (BO) after allogeneic stem cell transplantation (allo-SCT) is a late-onset, life-threatening respiratory complication that significantly reduces a patient's quality of life.	21424350
Trilateral Retinoblastoma	Stem Cell Exhaustion	High-dose chemotherapy followed by autologous and allogeneic peripheral blood stem cell transplantation for recurrent disseminated trilateral retinoblastoma.	21424400
Neoplasms	Stem Cell Exhaustion	The disseminated tumor disappeared after the first autologous peripheral blood stem cell transplantation (PBSCT) with high-dose melphalan and thiotepa.	21424400
Specialty Type - cancer, Neoplasms, Intracranial	Stem Cell Exhaustion	The cancer stem cell potential of TG20 cells was confirmed based on their expression of neural stem cell markers, their capacity of in vitro long-term proliferation and to form intracranial tumors in immune-deficient mice.	21425407
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Alternative lengthening of telomeres in human glioma stem cells.	21425407
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells are increasingly recognized as major therapeutic targets.	21425407
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	We report here the isolation of glioma stem cells (GSCs) maintaining telomere length through a telomerase-independent mechanism known as alternative lengthening of telomeres (ALTs).	21425407
Specialty Type - cancer	Stem Cell Exhaustion	Therefore, our data show for the first time that the ALT pathway can confer to cancer stem cells the capacity to sustain long-term proliferation as telomerase activity and importantly may also affect treatment efficiency.	21425407
Neutropenia, Asthenia, Venous Thromboembolism, Toxic effect, Abnormal digestive tract function, Atrial Fibrillation by ECG Finding, Myelosuppression, skin toxicity	Stem Cell Exhaustion	The major adverse events (AEs) associated with lenalidomide include: hematological toxicities (myelosuppression), mainly neutropenia, venous thromboembolism, gastrointestinal disturbance, skin toxicity, atrial fibrillation, asthenia, and decreased peripheral blood stem cell yield during stem cell collection when lenalidomide is used after a long period of time.	21431627
Gain, Loss	Stem Cell Exhaustion	Of note, the loss and gain of this capacity to differentiate coincided with the loss and gain of a subpopulation within the CD34(+) proliferative compartment with surface expression of the stem cell factor receptor (SCF-R/CD117/c-Kit).	21431918
Drug-induced	Stem Cell Exhaustion	In order to achieve high telomerase activity as detected in hematological stem cells, precursor cells from the acute-myeloid leukemia (AML)-derived cell line MUTZ3 were stably transduced with human telomerase reverse transcriptase (hTERT) to facilitate their growth potential, while preventing growth, and drug-induced senescence, and preserving their unique capacity for cytokine-dependent DC and LC differentiation.	21431918
Teratoma	Stem Cell Exhaustion	In particular, we found that these cells share the following features with ES: (i) high levels of embryonic stem cell markers (CD90, TRA1-60, TRA1-81, OCT-4, CD133, and SSEA-4); (ii) mRNA transcripts for Nanog and Rex-1; (iii) broader potency, being able to differentiate in cell types of all three germ layer, including smooth and skeletal muscle, osteoblasts, neurons, glial cells, and adipocytes; (iv) high levels of telomerase activity; (v) ability to form embryoid bodies; (vi) ability, after injection in murine blastocysts, to be localised within the inner cell mass; (vii) no teratoma formation after injection; (viii) in vivo tissue formation after transplantation.	21432784
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukemia (AML) is a heterogeneous clonal disorder of hematopoietic progenitor cells that presents genetic abnormalities in several genes, including NPM.	21434520
Hematological Disease	Stem Cell Exhaustion	This work aims at assessing and describing the most frequent clinical manifestations of the Graft-versus- Host Disease (GvHD) in the oral and maxillofacial region in paediatric patients affected by neoplastic or non neoplastic haematologic disorders who undergo specific haematopoietic stem cell transplantation (HSCT) protocols, with a view to detecting the potential pathological modifications that are recognised as the cause of a possible altered harmonious development of the child.	21434736
Hematological Disease	Stem Cell Exhaustion	Thirty-eight paediatric patients aged between 3 and 13 years, coming from the haematological department of Tor Vergata University (Roma, Italy) and affected by GvHD, assessed on the basis of their medical history and accurate clinical and instrumental exams, after having received haematopoietic stem cell transplantation for neoplastic or non neoplastic haematologic disorders, were enrolled in this study.	21434736
Neoplasms	Stem Cell Exhaustion	In conclusion, human gastric cancer cell lines enclose a phenotypically and genotypically distinct cell population with tumor stem cell features.	21435459
Neoplasms	Stem Cell Exhaustion	The side population (SP) of tumor cell lines shares characteristics with tumor stem cells.	21435459
Neoplasms	Stem Cell Exhaustion	The p53 tumor suppressor has been shown to negatively regulate the activity of the Shh effector, Gli1, in neural stem cells; however, the contribution of p53 to the regulation of Shh signaling in GNPs during cerebellar development has not been determined.	21437245
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Nineteen patients received therapy for acute myeloid leukemia, and 50 patients were autologous stem cell transplantation recipients.	21437589
Angiolymphoid hyperplasia	Stem Cell Exhaustion	Autologous stem cell transplantation in a rare multicentric Castleman disease of the plasma cell variant.	21437636
Graft-vs-Host Disease	Stem Cell Exhaustion	Spontaneous autologous graft-versus-host disease in plasma cell myeloma autograft recipients: flow cytometric analysis of hematopoietic progenitor cell grafts.	21440080
Multiple Myeloma	Stem Cell Exhaustion	Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients.	21440298
Specialty Type - cancer, Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	Its expression might be a suitable diagnostic and prognostic indicator of malignancy and a potential marker of cancer stem cells in solid tumors.	21440298
Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	The deficiency of glycosyl-phosphatidylinositol (GPI)-anchored proteins in plasma membranes of PIG-A gene mutated hematopoietic stem cells (HSCs) is so far insufficient to explain the domination of paroxysmal nocturnal hemoglobinuria (PNH) clone over the normal HSC.	21442308
Cytomegalovirus Infections	Stem Cell Exhaustion	In this first case-series of 6 stem cell transplant recipients who received preemptive artesunate treatment for CMV infection, we have examined the viral kinetics following institution of artesunate, and employed first-phase viral kinetics studies to calculate its antiviral effectiveness.	21443904
Lymphopenia, Unknown (origin) (qualifier value)	Stem Cell Exhaustion	Non-myeloablative hematopoietic stem cell transplantation in the treatment of severe idiopathic CD4+ lymphocytopenia.	21447008
Lymphopenia, Opportunistic Infections	Stem Cell Exhaustion	A 40-year-old man with severe chronic idiopathic CD4+ lymphocytopenia complicated with opportunistic infections was successfully treated with non-myeloablative allogeneic hematopoietic stem cell transplantation.	21447008
Lymphopenia	Stem Cell Exhaustion	Non-myeloablative allogeneic hematopoietic stem cell transplantation should be considered a treatment option for patients with severe forms of idiopathic CD4+ lymphocytopenia.	21447008
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	To examine mitochondrial gene expression in hematopoietic progenitor cells of patients with myelodysplastic syndromes (MDS).	21447369
Malignant neoplasm of stomach, Specialty Type - cancer	Stem Cell Exhaustion	Cancer spheres from gastric cancer patients provide an ideal model system for cancer stem cell research.	21448722
Specialty Type - cancer	Stem Cell Exhaustion	Interestingly, a single cancer stem cell generated a cancer sphere that contained various differentiated cells, supporting multi-potency and self-renewal of a cancer stem cell.	21448722
Malignant neoplasm of stomach, Specialty Type - cancer	Stem Cell Exhaustion	The above in vivo and in vitro results suggest that cancer stem cells, which are enriched in the EpCAM(+)/CD44(+) subpopulation of gastric cancer cells, provide an ideal model system for cancer stem cell research.	21448722
Specialty Type - cancer, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Cancer stem cells have been hypothesized to drive the growth and metastasis of tumors.	21448722
Specialty Type - cancer, Primary malignant neoplasm	Stem Cell Exhaustion	However, cancer stem cells from primary human gastric cancer tissues have not been isolated as yet.	21448722
Cardiovascular Diseases	Stem Cell Exhaustion	Dietary intake of phytoestrogen is associated with increased circulating endothelial progenitor cells in patients with cardiovascular disease.	21450646
CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology	Stem Cell Exhaustion	Eight patients (8.9%) underwent haematopoietic stem cell transplantation (HSCT), 12 (13.3%) received immunosuppressive therapy (IST) and 70 patients (77.7%) received other and supportive therapy.	21453618
PAFAH1B1 wt Allele, Bone marrow hypocellularity	Stem Cell Exhaustion	In MDS, activated T cells are thought to mediate bone marrow failure via overproduction of proinflammatory cytokines that cause stem cell apoptosis.	21454192
Waldenstrom Macroglobulinemia	Stem Cell Exhaustion	Autologous stem cell transplantation as a care option in Waldenstrom's macroglobulinemia.	21454216
Malignant Neoplasms	Stem Cell Exhaustion	Pandemic 2009 H1N1 influenza in patients with hematopoietic stem cell transplantation and hematologic malignancy: single center experience.	21455013
H1N1	Stem Cell Exhaustion	In this study, we present the results of active H1N1 surveillance in 32 patients who were treated at our hematology/stem cell transplantation clinic between December 2009 and January 2010.	21455013
Influenza due to Influenza A virus subtype H1N1	Stem Cell Exhaustion	Eight patients in the hematology clinic and 7 patients in the hematology/stem cell transplantation unit tested positive for pandemic H1N1 infection.	21455013
Impaired	Stem Cell Exhaustion	Clinical impact of pre-transplant pulmonary impairment on survival after allogeneic hematopoietic stem cell transplantation.	21455634
Impaired	Stem Cell Exhaustion	We retrospectively analyzed the clinical outcomes of patients with pulmonary impairment before undergoing allogeneic hematopoietic stem cell transplantation (HSCT) for the first time.	21455634
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Nonmyeloablative allogeneic stem cell transplantation in relapsed/refractory chronic lymphocytic leukemia: long-term follow-up, prognostic factors, and effect of human leukocyte histocompatibility antigen subtype on outcome.	21455998
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	The role of nonmyeloablative allogeneic stem cell transplantation (NST) in the treatment of chronic lymphocytic leukemia (CLL) is not well established.	21455998
Uterine Fibroids, Lipoma	Stem Cell Exhaustion	To understand the HMGA2-p14(Arf) -relationship in benign tumorigenesis, we performed a series of experiments on mesenchymal stem-cells, i.e., the proposed cells of origin of lipomas and uterine leiomyomas.	21456046
leukemia	Stem Cell Exhaustion	Ex vivo purging is an emerging technique for successful transplantation of autologous hematopoietic stem cells in the treatment of leukemia.	21457188
Alzheimers Disease	Stem Cell Exhaustion	If microglia telomere damage is causing Alzheimer's disease, self-donated bone marrow or dental pulp stem cell transplants could give rise to new microglia populations that would maintain neuronal health while the original resident microglia population died.	21458164
methyldopa	Stem Cell Exhaustion	To compare RPE derived from human embryonic stem cells (hES-RPE) and fetal RPE (fRPE) behavior on human Bruch's membrane (BM) from aged and AMD donors.	21460262
Multiple Myeloma	Stem Cell Exhaustion	Age at transplantation and outcome after autologous stem cell transplantation in elderly patients with multiple myeloma.	21460604
Trauma	Stem Cell Exhaustion	The study is designed to investigate the endothelial progenitor cell mobilization after injury and a potential use of circulating endothelial progenitor cells as a prognostic marker for evaluating trauma severity and clinical outcomes.	21460712
Traumatic	Stem Cell Exhaustion	Endothelial progenitor cells correlate with clinical outcome of traumatic brain injury.	21460712
Traumatic	Stem Cell Exhaustion	Endothelial progenitor cells play an active role in vascular repair and revascularization of tissue damaged by traumatic, inflammatory, and ischemic injures.	21460712
Traumatic	Stem Cell Exhaustion	We correlate the changes in circulating endothelial progenitor cells with the severity of traumatic brain injury.	21460712
Traumatic	Stem Cell Exhaustion	Changes in the levels of circulating endothelial progenitor cells were monitored for up to 21 days in 84 patients with traumatic brain injury.	21460712
Trauma	Stem Cell Exhaustion	Circulating endothelial progenitor cells in patients with improved Glasgow Coma Scale scores were significantly higher than those with deteriorated conditions and remained persistently low in patients who died of trauma.	21460712
Traumatic	Stem Cell Exhaustion	The results suggest that the level of circulating endothelial progenitor cells correlates with the clinical severity and outcome of traumatic brain injury and may offer potential as a prognostic marker for traumatic brain injury.	21460712
Intraepithelial Neoplasia, Squamous cell carcinoma	Stem Cell Exhaustion	Oral epithelial dysplasia and squamous cell carcinoma following allogeneic hematopoietic stem cell transplantation: clinical presentation and treatment outcomes.	21460866
Neoplasm Metastasis	Stem Cell Exhaustion	Late complications of allogeneic hematopoietic stem cell transplantation (HSCT) include a risk of secondary malignancies.	21460866
Therapy-related myelodysplastic syndrome	Stem Cell Exhaustion	The use of etoposide (VP-16) for stem cell mobilization has been reported as a significant risk factor for the development of therapy-related myelodysplasia/therapy-related AML (tMDS/tAML) after transplantation.	21460870
Lymphoma	Stem Cell Exhaustion	An XRCC1 polymorphism is associated with the outcome of patients with lymphoma undergoing autologous stem cell transplant.	21463129
Lymphoma	Stem Cell Exhaustion	High-dose chemotherapy supported by autologous stem cell transplant (ASCT) remains the treatment of choice for patients with lymphoma failing first-line chemotherapy.	21463129
Angina Pectoris, Acute myocardial infarction	Stem Cell Exhaustion	Circulating CD34+ progenitor cells and growth factors in patients treated with PCI for acute myocardial infarction or stable angina pectoris.	21463159
Hepatitis B, Malignant neoplasm of liver	Stem Cell Exhaustion	Does the hepatitis B antigen HBx promote the appearance of liver cancer stem cells?	21464043
Hollings Cancer Center	Stem Cell Exhaustion	HBV-encoded X antigen, HBx, and pathways implicated in the self-renewal of stem cells contribute to HCC, but it is not clear whether HBx expression promotes "stemness."	21464043
Specialty Type - cancer	Stem Cell Exhaustion	Thus, experiments were designed to test the hypothesis that HBx triggers malignant transformation by promoting properties that are characteristic of cancer stem cells (CSC).	21464043
Heart failure, Hypokinesia	Stem Cell Exhaustion	While hematopoietic stem cell transplantation was being planned, progressive cardiac failure developed with a striking hypokinesia of the left-ventricle free wall.	21464194
Hematologic Neoplasms	Stem Cell Exhaustion	Impact of immune modulation with anti-T-cell antibodies on the outcome of reduced-intensity allogeneic hematopoietic stem cell transplantation for hematologic malignancies.	21464372
Pterygium	Stem Cell Exhaustion	Because ultraviolet exposure is a risk factor for development and growth of pterygium, 1 possible explanation for this patient's findings is the effect of the excimer laser (which has a wavelength in the ultraviolet spectrum) on a previously insignificant corneal growth and/or the corneal limbal stem cells.	21464701
Graft-vs-Host Disease	Stem Cell Exhaustion	Thus, our findings suggest that MMF is safe and effective for the prevention and treatment of GVHD in patients who have received an allogeneic stem cell transplant.	21465117
Specialty Type - cancer, Neoplasms, Carcinogenesis	Stem Cell Exhaustion	Cancer testis (CT) antigens are potential candidates because their expression is restricted to tumors, and accumulating data suggest that they play important roles in cellular proliferation, stem cell function, and carcinogenesis.	21465317
Mantle cell lymphoma	Stem Cell Exhaustion	Autologous stem-cell transplantation in patients with mantle cell lymphoma beyond 65 years of age: a study from the European Group for Blood and Marrow Transplantation (EBMT).	21467125
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	Limited experience is available on the feasibility and efficacy of autologous stem-cell transplantation (ASCT) in patients with mantle cell lymphoma (MCL) beyond 65 years.	21467125
Fibrosis Assessment	Stem Cell Exhaustion	The thickness of myofibroblast layers increased towards Group 4 without cell proliferation, but CD34(+) cells, marking cells of haematopoetic lineage and progenitor cells (in lung fibrosis), were found in close proximity to tubules.	21467201
Tetraploidy	Stem Cell Exhaustion	The clinical course of this case suggests that hematopoietic stem cell transplantation during the first CR phase should be considered a treatment option for tetraploid AML.	21471699
HIV-Associated Lymphoproliferative Disorder	Stem Cell Exhaustion	[EBV-associated B-cell lymphoproliferative disorder of the elderly successfully treated with autologous peripheral blood stem cell transplantation and locoregional radiotherapy].	21471700
HIV-Associated Lymphoproliferative Disorder	Stem Cell Exhaustion	This is the first report of successful autologous stem cell transplantation for a patient with age-related EBV-associated B-cell lymphoproliferative disorder.	21471700
Multiple Myeloma	Stem Cell Exhaustion	[Bortezomib plus dexamethasone treatment followed by reduced-intensity allogeneic stem cell transplantation for multiple myeloma refractory to high-dose chemotherapy with autologous transplantation].	21471701
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We present two long-term survivors after allogeneic transplantation with reduced-intensity conditioning regimen following relapse after autologous stem cell transplantation (ASCT) for multiple myeloma (MM).	21471701
Dryness of eye	Stem Cell Exhaustion	Donor-recipient gender difference affects severity of dry eye after hematopoietic stem cell transplantation.	21475315
Dryness of eye	Stem Cell Exhaustion	To determine whether the incidence rate and severity of dry eye after hematopoietic stem cell transplantation varies with donor vs recipient gender.	21475315
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In the univariable analyses of the influence of pre-transplant variables on OS, poor-risk cytogenetics, number of BM blasts (>26%), MDS overt AML and CB as stem cell source were significantly associated with worse prognosis (p = .03, p = .01, p = .02 and p < .001, respectively).	21477348
Immunologic Deficiency Syndromes	Stem Cell Exhaustion	In vivo T-cell dynamics during immune reconstitution after hematopoietic stem cell gene therapy in adenosine deaminase severe combined immune deficiency.	21477850
Immunologic Deficiency Syndromes	Stem Cell Exhaustion	Gene therapy (GT) with hematopoietic stem cells is a promising treatment for inherited immunodeficiencies.	21477850
Malignant neoplasm of brain, Adult Glioblastoma	Stem Cell Exhaustion	The CD133 antigen has been described as a putative stem cell marker in malignant brain tumor that could identify such a tumorigenic population in a subset of glioblastoma.	21479688
Adult Glioblastoma	Stem Cell Exhaustion	The quantitative expression of CD133 stem cell antigen mRNA using real-time QRT-PCR was assessed in a cohort of 48 consecutive primary glioblastoma patients treated by chemoradiation with temozolomide.	21479688
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells are thought to represent the population of tumorigenic cells responsible for tumor development.	21479688
Aneurysm	Stem Cell Exhaustion	Presence of circulating endothelial progenitor cells and levels of stromal-derived factor-1a are associated with ascending aorta aneurysm size.	21481600
Peripheral Arterial Diseases	Stem Cell Exhaustion	Exercise training increases endothelial progenitor cells and decreases asymmetric dimethylarginine in peripheral arterial disease: a randomized controlled trial.	21481871
Childhood Breast Carcinoma, Metaplastic carcinoma	Stem Cell Exhaustion	Responses to liposomal Doxorubicin, bevacizumab, and temsirolimus in metaplastic carcinoma of the breast: biologic rationale and implications for stem-cell research in breast cancer.	21482991
Werner Syndrome, Progeria	Stem Cell Exhaustion	Here we describe the generation of induced pluripotent stem cells (iPSCs) from a patient with inherited dilated cardiomiopathy and 2 patients with distinct accelerated forms of aging, atypical Werner syndrome and Hutchinson Gilford progeria, all of which are caused by mutations in lamin A/C.	21483033
Granuloma of conjunctiva, Conjunctival melanosis, Special Handling Code - Dry	Stem Cell Exhaustion	Associated ocular features were limbal stem cell deficiency in nine eyes (64.3%), dry eye in all 14 eyes (100%), conjunctival melanosis in seven eyes (50%), pseudopterygium in two eyes (14.3%), anterior symblepharon in three eyes (21.4%) and conjunctival inflammatory granuloma in one eye (7.1%).	21484462
Angina Pectoris, Coronary Arteriosclerosis	Stem Cell Exhaustion	We evaluated the feasibility, safety and efficacy of intra-myocardial injection of autologous mesenchymal stromal cells derived endothelial progenitor cell (MSC) in patients with stable coronary artery disease (CAD) and refractory angina in this first in man trial.	21486102
Cardiovascular Diseases	Stem Cell Exhaustion	Statins, a major component of the prevention of cardiovascular disease, aid progenitor cell functions in vivo and in vitro.	21486281
Lymphoma, Follicular	Stem Cell Exhaustion	Impact of the use of autologous stem cell transplantation at first relapse both in naive and previously rituximab exposed follicular lymphoma patients treated in the GELA/GOELAMS FL2000 study.	21486862
Lymphoma, Follicular	Stem Cell Exhaustion	Regardless of front-line rituximab exposure, this study supports incorporating autologous stem cell transplantation in the therapeutic approach at first relapse for follicular lymphoma patients.	21486862
Enterovirus Gastroenteritis	Stem Cell Exhaustion	Norovirus gastroenteritis causes severe and lethal complications after chemotherapy and hematopoietic stem cell transplantation.	21487110
Cerebral Hemorrhage	Stem Cell Exhaustion	Cd34+ progenitor cells likely are involved in the good functional recovery after intracerebral hemorrhage in humans.	21488087
COL4A2 wt Allele, Cerebral Hemorrhage	Stem Cell Exhaustion	Our aim was to study the influence of CD34(+) progenitor cells in the outcome of intracerebral hemorrhage (ICH).	21488087
COL4A2 wt Allele	Stem Cell Exhaustion	These findings suggest that CD34(+) progenitor cells may participate in the functional recovery of ICH patients.	21488087
Hodgkin Disease, Malignant Fibrous Histiocytoma	Stem Cell Exhaustion	Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: evidence for genomic instability.	21488163
Autistic Disorder, Malignant Fibrous Histiocytoma	Stem Cell Exhaustion	We report a 14 year old autistic male, who developed malignant fibrous histiocytoma (MFH) two years after autologous stem cell transplantation for advanced stage HL.	21488163
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Plerixafor is a recently Food and Drug Administration (FDA)-approved CXCR4 antagonist, which is combined with granulocyte-colony-stimulating factor (G-CSF) to facilitate stem cell mobilization of lymphoma and myeloma patients.	21492180
Hematologic Neoplasms	Stem Cell Exhaustion	The targeted use of plerixafor increased the overall success rate of mobilizing a minimum number of CD34+ cells from 93% to 98% in patients with hematologic malignancies scheduled for autotransplant and increased the overall charges associated with stem cell collection in all patients by an average of 17%.	21492180
Cell Growth, Malignant Neoplasms, Venous Thromboembolism, Neoplasms, Communicable Diseases, Progressive neurologic deterioration	Stem Cell Exhaustion	We did not observe any central nervous system tumours, abnormal cell growths or neurological deterioration, and there was no evidence for venous thromboembolism, systemic malignancy or systemic infection in any of the patients following stem cell infusion.	21493695
Cerebrovascular accident	Stem Cell Exhaustion	While we would emphasize that the current study was unblinded, did not assess overall function or relative functional importance of different types of deficits, and does not exclude placebo effects or a contribution of recovery as a result of the natural history of stroke, our observations provide evidence supporting the feasibility and safety of delivery of a relatively large dose of autologous mesenchymal human stem cells, cultured in autologous human serum, into human subjects with stroke and support the need for additional blinded, placebo-controlled studies on autologous mesenchymal human stem cell infusion in stroke.	21493695
Cerebrovascular accident	Stem Cell Exhaustion	Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke.	21493695
Cerebrovascular accident, Infarction	Stem Cell Exhaustion	Transplantation of human mesenchymal stem cells has been shown to reduce infarct size and improve functional outcome in animal models of stroke.	21493695
Cerebrovascular accident	Stem Cell Exhaustion	Here, we report a study designed to assess feasibility and safety of transplantation of autologous human mesenchymal stem cells expanded in autologous human serum in stroke patients.	21493695
Cerebral cortex	Stem Cell Exhaustion	We report an unblinded study on 12 patients with ischaemic grey matter, white matter and mixed lesions, in contrast to a prior study on autologous mesenchymal stem cells expanded in foetal calf serum that focused on grey matter lesions.	21493695
Gastrointestinal mucositis	Stem Cell Exhaustion	A comparison of oral mucositis in allogeneic hematopoietic stem cell transplantation between conventional and reduced-intensity regimens.	21494780
Bacteremia, Gastrointestinal mucositis, Usual Severity Pain	Stem Cell Exhaustion	Severe oral mucositis developed in allogeneic hematopoietic stem cell transplantation (HSCT) accompanies intolerable pain and risk for systemic bacteremia infection.	21494780
Stomatitis	Stem Cell Exhaustion	Conventional stem cell transplantation (CST) and reduced-intensity regimens for allogeneic HSCT (RIST) may differently affect the occurrence and severity of oral mucositis.	21494780
Prostate carcinoma	Stem Cell Exhaustion	Haplotype analysis of prostate stem cell antigen and association with prostate cancer risk.	21497359
Prostate carcinoma	Stem Cell Exhaustion	Prostate stem cell antigen has become a promising target as a potential biomarker for prostate cancer, but to our knowledge there are no reports of a genetic variation of the PSCA gene associated with prostate cancer risk.	21497359
Fibroid Tumor	Stem Cell Exhaustion	To address the influence of genes involved in stem cell self-renewal and senescence on the growth of leiomyoma cells in vitro and to explore possible therapeutic implications of a targeted disruption of the p53-murine double minute 2 (MDM2) interaction.	21498692
Acute leukemia, Aplastic Anemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (allo-HSCT) was performed in 37 cases of acute leukemia, 10 of myelodysplastic syndrome, 5 of aplastic anemia, and 5 others.	21502710
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation (auto-HSCT) was performed in 34 cases of malignant lymphoma, 15 of multiple myeloma, and 8 others.	21502710
Nephrotic Syndrome, Amyloid nephropathy	Stem Cell Exhaustion	A long-term remission of renal amyloidosis with nephrotic syndrome after autologous peripheral blood stem-cell transplantation.	21502717
Nephrotic Syndrome, Amyloid nephropathy	Stem Cell Exhaustion	We report the case of a patient with renal amyloidosis associated with nephrotic syndrome who maintained remission for 6 years after undergoing high-dose chemotherapy followed by autologous peripheral blood stem-cell transplantation (auto-PBSCT).	21502717
Glioma	Stem Cell Exhaustion	Neuroepithelial stem cell marker nestin regulates the migration, invasion and growth of human gliomas.	21503585
liver and pancreas	Stem Cell Exhaustion	CX32 has three tissue-specific promoters, P1 which is specific for liver and pancreas, P1a specific for liver, oocytes and embryonic stem cells, and P2 which is nerve-specific.	21504505
Hematological Disease, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	In this study, we used Myelodysplastic Syndromes (MDSs), a heterogeneous family of clonal disorders of hematopoietic stem cells, as a general model to explore the network properties of the heterogeneity of complex diseases.	21505650
Specialty Type - cancer	Stem Cell Exhaustion	Taken together, our results show that cancer cells can program proangiogenic activity in CD11b(+) myelomonocytes during differentiation of their progenitor cells in a PlGF-dependent manner.	21507936
Mantle cell lymphoma	Stem Cell Exhaustion	Patterns and outcome of relapse after autologous stem cell transplantation for mantle cell lymphoma.	21509767
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation (autoSCT) has improved the outcome of patients with mantle cell lymphoma (MCL) considerably.	21509767
Therapy-related myelodysplastic syndrome	Stem Cell Exhaustion	In this study, we carried out metabolomic analysis of peripheral blood stem cell samples collected in a cohort of patients before hematopoietic cell transplantation to gain insights into the molecular and cellular pathogenesis of t-MDS.	21510650
Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Tumors with constitutive LIN28B expression exhibit increased expression of colonic stem cell markers LGR5 and PROM1, mucinous differentiation, and metastasis.	21512136
Graft-vs-Host Disease	Stem Cell Exhaustion	Successful neutrophil engraftment by reduced use of granulocyte colony-stimulating factor after allogeneic hematopoietic stem cell transplantation with mycophenolate mofetil for graft-versus-host disease prophylaxis.	21512728
HD Term Type	Stem Cell Exhaustion	In allogeneic hematopoietic stem cell transplantation (allo-SCT), most physicians in Japan utilize granulocyte colony-stimulating factor (G-CSF) at a high dose (HD) of 300 mg/m(2) per day for filgrastim to promote faster neutrophil engraftment.	21512728
Malignant Neoplasms	Stem Cell Exhaustion	Underlying conditions were haematopoietic stem cell transplantation (HSCT, 35), haematologic malignancy (HM, 35), solid-organ transplantation (SOT, 25), chronic immunosuppression (CI, 40) and other conditions (OC, 57).	21512792
Communicable Diseases	Stem Cell Exhaustion	In immunocompetent persons, cytomegalovirus (CMV) is thought to persist primarily in monocytes and myeloid progenitor cells, establishing a chronic infection.	21513787
Hematologic Neoplasms	Stem Cell Exhaustion	Patients with hematologic malignancies and hematopoietic stem cell transplantation recipients admitted to the hospital.	21515980
Angina, Unstable, Infarction	Stem Cell Exhaustion	Influence of preinfarction angina on the release kinetics of endothelial progenitor cells and cytokines during the week after infarction.	21517829
Angina, Unstable	Stem Cell Exhaustion	The aim of this study was to determine the possible involvement of endothelial progenitor cells (EPC), the vascular endothelial growth factor (VEGF) and the hepatocyte growth factor (HGF) in the development of preinfarction angina.	21517829
Acute leukemia	Stem Cell Exhaustion	We performed a retrospective single-center analysis of 604 CVC insertions in 193 patients with acute leukemia receiving intensive chemotherapy or stem cell transplantation.	21517892
Degenerative polyarthritis	Stem Cell Exhaustion	Mesenchymal stem cell therapy for knee osteoarthritis.	21518322
Hematologic Neoplasms	Stem Cell Exhaustion	[Comparison of curative efficacy after G-CSF-mobilized sibling HLA-matched peripheral blood hematopoietic stem cell transplantation versus that combined with BMT for patients with hematologic malignancies in a single center].	21518497
Hematologic Neoplasms	Stem Cell Exhaustion	This study was aimed to retrospectively analyze and compare the clinical curative efficacy of patients with hematologic malignancies after G-CSF-mobilized sibling HLA-matched (sm) peripheral blood hematopoietic stem cell transplantation (sm-allo-PBHSCT) and sm-allo-PBHSCT combined with bone marrow transplantation (BMT).	21518497
Alzheimers Disease	Stem Cell Exhaustion	Endothelial progenitor cells with Alzheimer's disease.	21518600
Up	Stem Cell Exhaustion	The patients with AD had significantly lower CD34(+)CD133(+) EPCs (CD34 and CD133 double positive endothelial progenitor cells) than the control subjects (P < 0.05).	21518600
Abnormality of red blood cells	Stem Cell Exhaustion	Most patients (16/22) with high myeloid progenitor cells (MyPC) (> 20%) also exhibited maturing myeloid cell abnormalities by FCM.	21520402
Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	An imbalance in progenitor cell populations reflects tumour progression in breast cancer primary culture models.	21521500
Childhood Breast Carcinoma, Neoplasms	Stem Cell Exhaustion	Many factors influence breast cancer progression, including the ability of progenitor cells to sustain or increase net tumour cell numbers.	21521500
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Deletions of derivative chromosome 9 are a poor prognostic factor in patients with chronic myeloid leukemia (CML) treated with hydroxyurea, interferon, or stem cell transplantation.	21523765
leukemia	Stem Cell Exhaustion	We are the first to demonstrate a direct link between stem cell factor SALL4, SP and drug resistance in leukemia.	21526180
Specialty Type - cancer	Stem Cell Exhaustion	This led to our investigation of the implication of SALL4 in drug resistance and its role in side population (SP) cancer stem cells.	21526180
PAFAH1B1 wt Allele, Aplastic Anemia, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	In aplastic anemia (AA), contraction of the stem cell pool may result in oligoclonality, while in myelodysplastic syndromes (MDS) a single hematopoietic clone often characterized by chromosomal aberrations expands and outcompetes normal stem cells.	21527527
Choroidal Neovascularization	Stem Cell Exhaustion	Amyloid beta enhances migration of endothelial progenitor cells by upregulating CX3CR1 in response to fractalkine, which may be associated with development of choroidal neovascularization.	21527754
Choroidal Neovascularization	Stem Cell Exhaustion	We have also shown that endothelial progenitor cells (EPCs) may contribute to the development of choroidal neovascularization (CNV).	21527754
Intrahepatic bile duct, Liver Cirrhosis, Hollings Cancer Center, Cholangiocarcinoma	Stem Cell Exhaustion	It seems possible in this case that hepatic progenitor cells located in reactive bile ductules in liver cirrhosis may have been responsible for the development of the cholangiocarcinoma and HCC, and that the former could have spread in the intrahepatic bile ducts and eventually formed grossly visible IPNB.	21528069
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	The myelodysplastic syndromes (MDSs) are hematologically diverse hematopoietic stem cell malignancies primarily affecting older individuals.	21531980
Behavior, Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	The new cancer stem cell concept proposes that the expression of such genes is potentially correlated with tumorigenesis and can affect some aspects of the cancer behavior, such as recurrence or metastasis.	21533858
Multiple Myeloma	Stem Cell Exhaustion	Melphalan 100 mg/m2 with stem cell support as first relapse treatment is safe and effective for myeloma patients with long remission after autologous stem cell transplantation.	21535157
Multiple Myeloma	Stem Cell Exhaustion	Today, a number of therapeutic options are available as the patient with myeloma relapses from initial treatment with high-dose melphalan and autologous stem cell transplantation (ASCT).	21535157
Multiple Myeloma	Stem Cell Exhaustion	In this retrospective study, we account for the outcome of 66 patients with myeloma in first systemic relapse after ASCT, who were treated with intermediate-dose melphalan, 100 mg/m2, and stem cell support (MEL 100).	21535157
Alzheimers Disease	Stem Cell Exhaustion	Tenuigenin, an active component of Polygala tenuifolia root extracts, has been shown to provide antioxidative and anti-aging effects in Alzheimer's disease, as well as to promote proliferation and differentiation of neural progenitor cells.	21536104
Supraventricular Tachycardia by ECG Finding, Supraventricular tachycardia	Stem Cell Exhaustion	We retrospectively reviewed the data on patients who received hematopoietic stem cell transplant (bone marrow transplant; BMT) from 1998 to 2005 and developed supraventricular tachycardia (SVT) during the same hospital admission.	21538392
Malignant neoplasm of stomach	Stem Cell Exhaustion	Association of a common genetic variant in prostate stem-cell antigen with gastric cancer susceptibility in a Korean population.	21538581
Malignant neoplasm of stomach	Stem Cell Exhaustion	A recent genome wide association study (GWAS) indentified a significant association between rs2294008 (C > T) polymorphism in prostate stem-cell antigen (PSCA) and increased risk of gastric cancer in Japanese and Korean populations.	21538581
Graft-vs-Host Disease, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Donor lymphocyte infusions have been effective in patients with chronic myeloid leukemia (CML) relapsing after allogeneic stem cell transplantation, but their use is associated with the risk of graft-versus-host disease.	21540460
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Fourteen CML patients received conditioning therapy followed by CD34(+)-selected peripheral blood stem cells from matched siblings (n = 7) or unrelated (n = 7) donors.	21540460
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The impact of early human cytomegalovirus (HCMV) replication on leukemic recurrence was evaluated in 266 consecutive adult (median age, 47 years; range, 18-73 years) acute myeloid leukemia patients, who underwent allogeneic stem cell transplantation (alloSCT) from 10 of 10 high-resolution human leukocyte Ag-identical unrelated (n = 148) or sibling (n = 118) donors.	21540462
Aplastic Anemia	Stem Cell Exhaustion	First-line matched related donor hematopoietic stem cell transplantation compared to immunosuppressive therapy in acquired severe aplastic anemia.	21541024
Aplastic Anemia	Stem Cell Exhaustion	Acquired severe aplastic anemia (SAA) is a rare and progressive disease characterized by an immune-mediated functional impairment of hematopoietic stem cells.	21541024
Coronary artery, Restenosis	Stem Cell Exhaustion	Two-year follow-up of the Genous(tm) endothelial progenitor cell capturing stent versus the Taxus Liberte stent in patients with de novo coronary artery lesions with a high-risk of restenosis: a randomized, single-center, pilot study.	21542109
Atherosclerosis	Stem Cell Exhaustion	Endothelial progenitor cells (CD34+KDR+) and monocytes may provide the development of good coronary collaterals despite the vascular risk factors and extensive atherosclerosis.	21543296
Atherosclerosis, Coronary Arteriosclerosis	Stem Cell Exhaustion	Endothelial progenitor cells can be mobilized from bone marrow to induce the coronary collateral growth in case of myocardial ischemia even in presence of the vascular risk factors and extensive atherosclerosis.	21543296
Idiopathic Pulmonary Fibrosis	Stem Cell Exhaustion	Mutations in the genes encoding telomerase (TERT and TERC) cause IPF through shortening of telomere lengths and probable exhaustion of lung stem cells.	21543794
Hepatitis B	Stem Cell Exhaustion	Development of immunity against hepatitis B virus after donor lymphocyte infusion in a peripheral blood stem cell transplantation recipient with chronic hepatitis B.	21544586
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	She received allogeneic matched unrelated donor peripheral blood stem cell transplantation (allo-MUD-PBSCT) for her refractory acute myeloid leukemia (AML).	21544586
Specialty Type - cancer	Stem Cell Exhaustion	Development and implementation of an Internet-based survivorship care program for cancer survivors treated with hematopoietic stem cell transplantation.	21544671
Osteoporotic Fractures	Stem Cell Exhaustion	Proliferation and differentiation potential of human adipose-derived mesenchymal stem cells isolated from elderly patients with osteoporotic fractures.	21545685
Osteoporotic Fractures	Stem Cell Exhaustion	Aging has less effect on adipose-derived mesenchymal stem cells (ADSCs) than on bone marrow-derived mesenchymal stem cells (BMSCs), but whether the fact holds true in stem cells from elderly patients with osteoporotic fractures is unknown.	21545685
Hematopoietic Cell Transplant Recipient	Stem Cell Exhaustion	A prospective study was performed to collect data regarding risk factors and outcome of A/H1N1 in hematopoietic stem cell transplant recipients.	21546495
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Targeting constitutively activated FMS-like tyrosine kinase 3 [(FLT3); FLT3-ITD] with tyrosine kinase inhibitor (TKI) in acute myeloid leukemia (AML) leads to clearance of blasts in the periphery but not in the bone marrow, suggesting a protective effect of the marrow niche on leukemic stem cells.	21546568
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Thus, TKIs with first-generation inhibitors fail to eradicate early leukemic stem/progenitor cells in FLT3-ITD(+) AML.	21546568
Heart failure	Stem Cell Exhaustion	hCSCs expressing only IGF-1R synthesize both IGF-1 and IGF-2, which are potent modulators of stem cell replication, commitment to the myocyte lineage, and myocyte differentiation, which points to this hCSC subset as the ideal candidate cell for the management of human heart failure.	21546606
Coronary Arteriosclerosis	Stem Cell Exhaustion	Age and coronary artery disease may negatively affect the function of human cardiac stem cells (hCSCs) and their potential therapeutic efficacy for autologous cell transplantation in the failing heart.	21546606
Neoplasms, Malignant neoplasm of ovary, Specialty Type - cancer	Stem Cell Exhaustion	Recently, accumulating evidence has suggested that tumors, including ovarian cancer, are composed of a heterogeneous cell population with a small subset of cancer stem cells (CSCs) that sustain tumor formation and growth.	21547690
Hepatitis B, Multiple Myeloma, Communicable Diseases	Stem Cell Exhaustion	Risk of hepatitis B reactivation and the role of novel agents and stem-cell transplantation in multiple myeloma patients with hepatitis B virus (HBV) infection.	21551005
Osteopetrosis	Stem Cell Exhaustion	She later went on to have stem cell transplantation to treat the osteopetrosis.	21552996
Malignant neoplasm of stomach	Stem Cell Exhaustion	Stem cell associated genes working with one miRNA cluster have different clinic pathologic values in gastric cancer.	21553350
Malignant Neoplasms	Stem Cell Exhaustion	Also, stem cell associated genes are emerging as predictors of cancer malignancy.	21553350
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells are nowadays considered to be the origin of cancer.	21553350
Acute lymphocytic leukemia	Stem Cell Exhaustion	She was treated with combined acute myeloid leukaemia/acute lymphoblastic leukaemia induction therapy followed by autologous stem cell transplantation.	21553470
Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	To investigate the presence of T cells with natural killer cell receptors (NKR) in paroxysmal nocturnal hemoglobinuria (PNH), and their potential involvement in clonal expansion of glycosylphosphatidylinositol (GPI)-deficient hematopoietic stem cells by selective immune attack to normal and not GPI-deficient hematopoietic stem cells.	21554925
Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	T cells expressing the activating NK-cell receptors KIR2DS4, NKG2C and NKG2D are elevated in paroxysmal nocturnal hemoglobinuria and cytotoxic toward hematopoietic progenitor cell lines.	21554925
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	Elevated T cell subsets in PNH were assessed for differential cytotoxic lysis of GPI(+) and GPI(-) CD34(+) hematopoietic progenitor cell lines.	21554925
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	NKR(+) cytotoxic T-lymphocyte lines isolated from PNH patient peripheral blood and bone marrow displayed high cytotoxicity towards CD34(+) hematopoietic progenitor cell lines and K562 cells, suggesting major histocompatibility complex class I-independent cytotoxicity.	21554925
Leukemia, Myelocytic, Acute, Chromosome Aberrations	Stem Cell Exhaustion	Persistence of cytogenetic abnormalities at complete remission after induction in patients with acute myeloid leukemia: prognostic significance and the potential role of allogeneic stem-cell transplantation.	21555694
Leukemia, Myelocytic, Acute, Chromosome Aberrations	Stem Cell Exhaustion	To determine the prognostic impact of persistent cytogenetic abnormalities at complete remission (CR) on relapse-free survival (RFS) and overall survival (OS) in patients with acute myeloid leukemia (AML) and to examine the potential role of allogeneic stem-cell transplantation (SCT) in this setting.	21555694
Prostate carcinoma	Stem Cell Exhaustion	Endothelial progenitor cells and circulating endothelial cells in early prostate cancer: a comparison with plasma vascular markers.	21557269
Specialty Type - cancer	Stem Cell Exhaustion	Separate studies indicate that endothelial perturbation, as demonstrated by abnormal endothelial progenitor cells (EPCs), circulating endothelial cells (CECs), and plasma markers such as von Willebrand factor (vWf) and soluble E selectin (sEsel) are present in cancer.	21557269
Thalassemia	Stem Cell Exhaustion	Antiphospholid antibody syndrome and Hb E/Beta thalassemia disease post-allogeneic stem cell transplantation.	21557460
Stable chronic Graft vs Host Disease, Thalassemia, Chronic graft-versus-host disease, Antiphospholipid Antibodies	Stem Cell Exhaustion	We report a 10-year-old male with Hb E/Beta thalassemia disease who developed chronic graft-versus-host disease (cGVHD) of antiphospholipid antibody syndrome after successful allogeneic stem cell transplantation (SCT).	21557460
Branchioma, S100A4 protein, human	Stem Cell Exhaustion	Branchial cyst carcinoma revisited: stem cells, dormancy and malignant transformation.	21558916
Carcinogenesis	Stem Cell Exhaustion	The wide recognition of stem cells and their role in carcinogenesis provides a new context for the etiopathogenesis of controversial and rare entities such as the BCCC.	21558916
Branchioma, Neoplasms	Stem Cell Exhaustion	We argue for the first time the hypothesis that congenital branchial cysts and BCCC tumors may result from progenitor cell rests of the embryological branchial development.	21558916
Histogenic Process	Stem Cell Exhaustion	Although the histogenesis of ESFT is controversial, mesenchymal (MSC) and/or neural crest (NCSC) stem cells have been implicated as cells of origin.	21559395
Kidney Diseases, Stricture of ureter, Hemorrhagic cystitis	Stem Cell Exhaustion	Polyoma virus is a recognized cause of hemorrhagic cystitis, viral nephropathy, and ureteral stricture in renal and stem cell transplant recipients.	21559788
Lymphoproliferative Disorders	Stem Cell Exhaustion	Epstein-Barr virus-associated post-transplant lymphoproliferative disease (EBV-PTLD) is a life-threatening complication following allogeneic hematopoietic stem cell transplantation (HSCT).	21559814
Immunologic Deficiency Syndromes, Communicable Diseases	Stem Cell Exhaustion	We report an 11-month-old boy with severe combined immunodeficiency dying of serious disseminated BCG infection despite anti-tuberculosis therapy and blood stem cell transplantation.	21560422
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Autologous blood stem cell transplantation for Hodgkin and non-Hodgkin lymphoma: complications and outcome.	21561042
Toxic effect, Infection, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	We analysed data on patients of Hodgkin and non-Hodgkin lymphoma treated with high dose chemotherapy followed by autologous stem cell transplantation to determine the toxicity, pattern of infections and long-term outcome.	21561042
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Our findings suggest that alterations in KIR/KIR-L matching, such as increased 3DL2 and decreased 2DS1 mismatch, and in the polymorphisms of TGFb1, IFN-g, TNF- a and IL-10 may account for the propensity to immunemediated killing of hematopoietic stem cells and/or ineffective hematopoiesis characteristic of AA and MDS.	21561401
Disease, Hyperplasia	Stem Cell Exhaustion	Mastocytoses represent a heterogeneous group of stem cell disorders marked by an abnormal hyperplasia and accumulation of mast cells in one or more tissues, including bone marrow, gastrointestinal tract, liver, spleen, lymph nodes and skin.	21564325
Hepatitis B	Stem Cell Exhaustion	Changes of hepatitis B virus serologic status after allogeneic hematopoietic stem cell transplantation and impact of donor immunity on hepatitis B virus.	21565276
Multiple Myeloma	Stem Cell Exhaustion	Factors influencing the outcome of a second autologous stem cell transplant (ASCT) in relapsed multiple myeloma: a study from the British Society of Blood and Marrow Transplantation Registry.	21565277
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplant as primary (first ASCT) therapy in multiple myeloma (MM) is standard practice.	21565277
Hematologic Neoplasms, Pregnancy Complications, Infectious, Mycoses	Stem Cell Exhaustion	An electronic medical record system, the "Hema e-Chart", was designed and implemented to collect information prospectively on infectious complications, particularly on invasive fungal diseases, in patients with hematologic malignancies treated with chemotherapy and/or autologous or allogenic hemopoietic stem cell transplantation.	21565903
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This study shows an extremely low incidence of meningeal relapse in adult patients with acute myeloid leukemia treated with modern protocols including stem cell transplantation without intrathecal prophylaxis.	21565904
Thrombasthenia	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation in Glanzmann thrombasthenia complicated by platelet alloimmunization.	21567370
Thrombasthenia	Stem Cell Exhaustion	For Thrombasthenia Glanzmann (GT) patients presenting with a severe clinical phenotype due to complete lack of thrombocyte function or increased titres of anti-platelet antibodies hematopoietic stem cell transplantation (SCT) is the only curative therapy.	21567370
Antilymphocyte Serum	Stem Cell Exhaustion	The intrathecal synthesis of CCL2 suggests the involvement of adult neural stem cells and microglial activation in ALS pathogenesis which needs further investigation.	21569455
Ocular Cicatricial Pemphigoid, Corneal dystrophy, Lattice type 3, Burn injury, Stevens-Johnson Syndrome	Stem Cell Exhaustion	Forty eyes in 36 patients with total limbal stem cell deficiency (Stevens-Johnson syndrome in 12 eyes, chemical or thermal burns in 11 eyes, ocular cicatricial pemphigoid [OCP] in 9 eyes, pseudo-OCP in 7 eyes, and gelatinous drop-like dystrophy in 1 eye) were treated at the Department of Ophthalmology, Tokyo Dental College, Chiba, Japan.	21571372
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Assessing the charges associated with hematopoietic stem cell mobilization and remobilization in patients with lymphoma and multiple myeloma undergoing autologous hematopoietic peripheral blood stem cell transplantation.	21575005
Hematopoietic Stem Cell Mobilization	Stem Cell Exhaustion	The purpose of this study was to perform a detailed analysis of the charges associated with chemomobilization and remobilization of autologous hematopoietic stem cells (HSCs) and to quantify medical costs and resource utilization associated with these procedures.	21575005
Aneurysm, Ruptured	Stem Cell Exhaustion	Mobilization of circulating endothelial progenitor cells after endovascular therapy for ruptured cerebral aneurysms.	21575677
Vascular System Injuries	Stem Cell Exhaustion	Emerging evidence shows that circulating endothelial progenitor cells (EPCs) promote regeneration of the endothelium at sites of vessel injury.	21575677
BCL6 Positive	Stem Cell Exhaustion	(90)Y ibritumomab tiuxetan (Zevalin) combined with BEAM (Z -BEAM) conditioning regimen plus autologous stem cell transplantation in relapsed or refractory low-grade CD20-positive B-cell lymphoma.	21575926
Lymphoma	Stem Cell Exhaustion	This study was designed to evaluate the safety and efficacy of a conventional dose of yttrium-90 ((90)Y) ibritumomab tiuxetan combined with the etoposide rabinoside acytarabine melphalan (BEAM) regimen before autologous stem cell transplantation (ASCT) in chemosensitive relapsed or refractory low-grade B-cell lymphomas.	21575926
palladium, Parkinson Disease	Stem Cell Exhaustion	Parkinson disease (PD) involves the selective loss of midbrain dopamine (mDA) neurons and is a possible target disease for stem cell-based therapy.	21576821
Trigeminal Neuralgia, Diplopia	Stem Cell Exhaustion	Extramedullary relapse presenting as trigeminal neuralgia and diplopia after allogeneic hematopoietic stem cell transplantation.	21576839
Trigeminal Neuralgia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 23-year-old woman presented with trigeminal neuralgia four months after hematopoietic stem cell transplantation (HSCT) for acute myeloblastic leukemia.	21576839
Colorectal Carcinoma	Stem Cell Exhaustion	Expression of the adult intestinal stem cell marker Lgr5 in the metastatic cascade of colorectal cancer.	21577318
Specialty Type - cancer, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	The recently advanced cancer stem cell model postulates that progression and metastasis of cancer are mainly driven by tumor cells with stem cell properties.	21577318
Colorectal Carcinoma, Intestinal Cancer	Stem Cell Exhaustion	Intestinal cancer stem cells are difficult to study due to the lack of reliable markers, but expression of the Wnt target gene Lgr5 is promising to define at least stem cell like cells in intestinal and colorectal cancer.	21577318
Colorectal Carcinoma	Stem Cell Exhaustion	The aim of this study was to find a possible link of stem cell like cancer cells to the metastatic process of colorectal cancer.	21577318
Colorectal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	In conclusion, our results point to rare evidence of Lgr5 positive stem cell like cells in the metastatic cascade of colorectal cancer, but these few cells might be biologically powerful in the metastatic process of cancer subsets.	21577318
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Intermediate intensity conditioning regimen containing FLAMSA, treosulfan, cyclophosphamide, and ATG for allogeneic stem cell transplantation in elderly patients with relapsed or high-risk acute myeloid leukemia.	21584670
Toxic effect	Stem Cell Exhaustion	Lower dosage of total body irradiation (TBI) and chemotherapy in reduced-intensity conditioning (RIC) regimens prior to allogeneic stem cell transplantation have reduced the toxicity of the conditioning and non-relapse mortality.	21584670
Impaired cognition, "Alzheimers Disease	Stem Cell Exhaustion	Stem cell factor plasma levels are decreased in Alzheimer's disease patients with fast cognitive decline after one-year follow-up period: the Pythia-study.	21593573
Stem Cell Factor	Stem Cell Exhaustion	Stem cell factor (SCF) is a hematopoietic growth factor that promotes neuroprotective effects and supports neurogenesis in the brain.	21593573
REG1CP gene, Neoplastic Stem Cells	Stem Cell Exhaustion	We conclude that the presence of >=15% RS in the post-therapy setting is not necessarily indicative of a clonal stem cell neoplasm.	21596435
Degenerative polyarthritis	Stem Cell Exhaustion	Several studies have been directed toward using MSCs from patients with osteoarthritis (OA) for cartilage repair, not only because these are the ones that will require a source of autologous stem cells if biological repair of cartilage lesions is to be a therapeutic option, but also to further an understanding of stem cell differentiation.	21599539
Neutropenia, Infection, Multiple Myeloma	Stem Cell Exhaustion	CD4(+) CD28(+) lymphocytes on day 5 after high-dose melphalan for multiple myeloma predict a low risk of infections during severe neutropenia and are associated with the number of reinfused T lymphocytes of the autologous stem cell graft.	21599548
Multiple Myeloma	Stem Cell Exhaustion	Residual leukocytes in the peripheral blood on day 5 after autologous blood stem cell transplantation were analyzed by three-color flow cytometry in 55 consecutive patients with multiple myeloma.	21599548
Multiple Myeloma	Stem Cell Exhaustion	Prognostic value of bone marrow microvessel density and angiogenic cytokines in patients with multiple myeloma undergoing autologous stem cell transplant.	21599578
Septicemia	Stem Cell Exhaustion	Blood stream infections after allogeneic stem cell transplantation: a single-center experience with the use of levofloxacin prophylaxis.	21599817
Septicemia, Behavioral Symptoms Index Composite Score (BASC-2)	Stem Cell Exhaustion	Blood stream infections (BSIs) remain one of the major causes of morbidity and mortality for patients receiving an allogeneic hematopoietic stem cell transplantation (HSCT).	21599817
Prostate carcinoma	Stem Cell Exhaustion	Expression of prostate-specific antigen (PSA), prostate-specific membrane antigen (PSMA), human kallikrein 2 (hK2), prostate stem cell antigen (PSCA), and differential display code 3 (DD3) in 2215 LNs isolated from 120 patients with localized prostate cancer were assessed by fully quantitative real-time RT-PCR.	21600799
Premalignant, Specialty Type - cancer	Stem Cell Exhaustion	Repositioning chloroquine and metformin to eliminate cancer stem cell traits in pre-malignant lesions.	21600837
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Such ideal molecules, which are expected to molecularly abrogate all the instrumental mechanisms acquired by migrating cancer stem cells (CSCs) to by-pass tumour suppressor barriers, might already exist.	21600837
Hodgkin Disease	Stem Cell Exhaustion	Prognostic significance of FDG-PET in relapsed or refractory classical Hodgkin lymphoma treated with standard salvage chemotherapy and autologous stem cell transplantation.	21601641
Malignant Neoplasms	Stem Cell Exhaustion	Fludarabine, antithymocyte globulin, and very low-dose busulfan for reduced-intensity conditioning before allogeneic stem cell transplantation in patients with lymphoid malignancies.	21601642
Specialty Type - cancer, Squamous cell carcinoma	Stem Cell Exhaustion	To detect the expression of stem cell transcription factor Oct-4 in squamous cell carcinoma (SCC) and seborrheic keratosis (SK) and its association with cancer stem cells.	21602158
Neoplasms	Stem Cell Exhaustion	The Oct-4-positive cells in SCC and SK are probably tumor stem cells.	21602158
Liver Failure, Hepatitis B	Stem Cell Exhaustion	Autologous bone marrow mesenchymal stem cell transplantation in liver failure patients caused by hepatitis B: short-term and long-term outcomes.	21608000
Liver Failure, Hepatitis B	Stem Cell Exhaustion	Our study aimed to investigate the short-term efficacy and long-term prognosis of liver failure patients caused by hepatitis B after a single transplantation with autologous marrow mesenchymal stem cells (MMSCs).	21608000
Specialty Type - cancer	Stem Cell Exhaustion	(v) How the impairment of stem cell fitness, as occurs in old age, can promote selection for adaptive mutations and cancer initiation.	21610109
Specialty Type - cancer	Stem Cell Exhaustion	(vi) Why differential maintenance of stem cell fitness may explain how different vertebrate species with enormous differences in life span and body size similarly avoid cancer through reproductive years.	21610109
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease (aGvHD) is a common complication of allogeneic stem cell transplantation.	21616558
Specialty Type - cancer, Pancreatic carcinoma	Stem Cell Exhaustion	Alpha-fetoprotein-producing pancreatic cancer cells possess cancer stem cell characteristics.	21616586
Specialty Type - cancer, Pancreatic carcinoma	Stem Cell Exhaustion	We aimed to demonstrate the existence of cancer stem cells in human pancreatic cancer, and to clarify that they are alpha-fetoprotein (AFP) producing cells.	21616586
Pancreatic carcinoma	Stem Cell Exhaustion	The AFP-producing cells were shown to be putative pancreatic cancer stem cells.	21616586
Coronary Arteriosclerosis	Stem Cell Exhaustion	Prospective randomised trial evaluating a paclitaxel-coated balloon in patients treated with endothelial progenitor cell capturing stents for de novo coronary artery disease.	21617163
Coronary Arteriosclerosis	Stem Cell Exhaustion	To define the impact of paclitaxel-coated balloon angioplasty plus endothelial progenitor cell capturing (EPC) stent implantation in de novo coronary artery disease.	21617163
NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology	Stem Cell Exhaustion	CD44 as a stem cell marker in head and neck squamous cell carcinoma.	21617876
Specialty Type - cancer	Stem Cell Exhaustion	These cancer stem cells (CSCs) have features of somatic stem cells such as selfrenewal, proliferation and differentiation.	21617876
Amyloidosis	Stem Cell Exhaustion	Comparison of hematopoietic progenitor cell collections using the COBE Spectra version 7 and Amicus version 3.1 for patients with AL amyloidosis.	21618597
Acute Coronary Syndrome	Stem Cell Exhaustion	ACE inhibition modulates endothelial apoptosis and renewal via endothelial progenitor cells in patients with acute coronary syndromes.	21619382
Neoplasms	Stem Cell Exhaustion	VIL1-positive tumors were further examined histologically and immunostained for epithelial cell surface marker, EpCAM, and mesenchymal stem cell marker, CD44.	21623163
Psoriasis	Stem Cell Exhaustion	The mesenchymal stem cell profile in psoriasis.	21623755
Atopy, Psoriasis	Stem Cell Exhaustion	To isolate MSCs in patients with psoriasis and to compare them with those obtained from atopic and healthy subjects, in order to analyse whether MSCs show some typical psoriatic profiles and to understand whether pathophysiological events leading to psoriasis start early at the stem cell level.	21623755
Sleep disturbances	Stem Cell Exhaustion	Sleep disturbance in hospitalized recipients of stem cell transplantation.	21624862
Sleep disturbances	Stem Cell Exhaustion	Although sleep disturbances have been studied in recipients of hematopoietic stem cell transplantations (HSCTs), these studies have not examined the acute phase of transplantation.	21624862
Sleep disturbances, Hemopoietic stem cell transplant	Stem Cell Exhaustion	The current study aimed to identify the level of sleep disturbance in this patient population, identify factors contributing to decreased ability to sleep for hospitalized recipients of HSCT, and compare the differences in sleep disturbance between age, gender, type of transplantation, and initial stem cell transplantation versus readmission for transplantation-associated complications.	21624862
Multiple System Atrophy	Stem Cell Exhaustion	Mesenchymal stem cells in a transgenic mouse model of multiple system atrophy: immunomodulation and neuroprotection.	21625635
Psychological Distress	Stem Cell Exhaustion	Family caregivers of allogeneic hematopoietic stem cell transplant (HSCT) patients are at risk for experiencing significant psychological distress yet screening caregivers has not been well studied.	21626610
Graft-vs-Host Disease, Stable chronic Graft vs Host Disease, Autoimmune Diseases, Chronic graft-versus-host disease	Stem Cell Exhaustion	Because patients with classic and overlap chronic GVHD (cGVHD) have features of autoimmune diseases, we studied the association of recipient and/or donor BAFF SNPs with the phenotype of GVHD after allogeneic stem cell transplantation.	21628416
Aspergillosis, Acute lymphocytic leukemia	Stem Cell Exhaustion	Isolated cutaneous aspergillosis in an acute lymphoblastic leukemia patient after allogeneic stem cell transplantation.	21628821
Acute lymphocytic leukemia, Aspergillosis	Stem Cell Exhaustion	We report a 26-year-old male with acute lymphoblastic leukemia who developed cutaneous aspergillosis after undergoing combined immunosuppressive treatment including corticosteroid, cyclosporine A, mychophenolate mofetil and mesenchymal stem cells for steroid refractory skin acute graft versus host disease after myeloablative haematopoietic stem cell transplantation.	21628821
Anemia, Sickle Cell	Stem Cell Exhaustion	The patient's past medical history was significant for sickle cell disease and she had undergone an allogeneic stem cell transplant 4 months prior with Sirolimus prescribed to prevent rejection.	21628828
Hepatitis, Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	We present a case of life-threatening Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) with severe hepatitis that was successfully treated by allogeneic stem cell transplantation from an unrelated donor.	21628862
Multiple Myeloma	Stem Cell Exhaustion	Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience.	21630163
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy with subsequent autologous stem cell transplantation (ASCT) is an important treatment option in younger patients with multiple myeloma (MM).	21630163
Alzheimers Disease	Stem Cell Exhaustion	Adipocytokines and CD34 progenitor cells in Alzheimer's disease.	21633502
Coronary Arteriosclerosis	Stem Cell Exhaustion	Adipocytokines and CD34(+) progenitor cells are associated with the progression and prognosis of atherosclerotic diseases.	21633502
Up	Stem Cell Exhaustion	In the present study, we measured in 41 patients with early AD and 37 age- and weight-matched healthy controls blood concentrations of adiponectin and leptin by enzyme linked immunoabsorbent assay and of CD34(+) progenitor cells using flow cytometry.	21633502
Up	Stem Cell Exhaustion	Our findings suggest that low plasma levels of leptin and increased numbers of CD34(+) progenitor cells are both associated with AD.	21633502
Up	Stem Cell Exhaustion	In addition, the results of our study provide first evidence that increased leptin plasma levels are associated with a reduced number of CD34(+) progenitor cells in AD patients.	21633502
Up	Stem Cell Exhaustion	These findings point towards a combined involvement of leptin and CD34(+) progenitor cells in the pathogenesis of AD.	21633502
Up, Coronary Arteriosclerosis	Stem Cell Exhaustion	Thus, plasma levels of leptin and circulating CD34(+) progenitor cells could represent an important molecular link between atherosclerotic diseases and AD.	21633502
Up	Stem Cell Exhaustion	Further studies should clarify the pathophysiological role of both adipocytokines and progenitor cells in AD and possible diagnostic and therapeutic applications.	21633502
Respiratory Failure, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Successful allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia during respiratory failure and invasive mechanical ventilation.	21633813
Hematological Disease	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment option for various hematologic disorders.	21633813
respiratory	Stem Cell Exhaustion	Because of respiratory deterioration, stem cell infusion was postponed.	21633813
Astrocytoma	Stem Cell Exhaustion	BRAF activation induces transformation and then senescence in human neural stem cells: a pilocytic astrocytoma model.	21636552
Neoplasms	Stem Cell Exhaustion	We investigated the functional effect of constitutive BRAF activation in normal human neural stem and progenitor cells to determine its role in tumor induction in the brain.	21636552
Chronic Kidney Disease, CTCAE	Stem Cell Exhaustion	Effect of darbepoetin alfa on endothelial progenitor cells and vascular reactivity in chronic kidney disease.	21636677
Liver carcinoma, Specialty Type - cancer, Hollings Cancer Center	Stem Cell Exhaustion	In the present study, we analyzed the regulatory function of RUNX3 on Jagged-1 (JAG1) expression and cancer stem cell (CSC) signaling in hepatocellular carcinoma (HCC).	21637926
Liver carcinoma, Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Restored expression of the tumor suppressor gene RUNX3 reduces cancer stem cells in hepatocellular carcinoma by suppressing Jagged1-Notch signaling.	21637926
LMNA wt Allele	Stem Cell Exhaustion	Two groups recently reported the successful generation and characterization of induced pluripotent stem cells (iPSCs) from HGPS fibroblasts.	21639955
Colorectal Carcinoma	Stem Cell Exhaustion	SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells.	21640118
Colorectal Carcinoma, Specialty Type - cancer, Cytogenetic Complete Response	Stem Cell Exhaustion	Little is known about the mechanisms that regulate the stem cell-like features of cancer cells; we investigated genes associated with stem cell-like features of colorectal cancer (CRC) cells.	21640118
Cytogenetic Complete Response	Stem Cell Exhaustion	In CRC tissues, SNAIL and IL-8 were coexpressed with the stem cell marker CD44 but not with CD133 or CD24.	21640118
Specialty Type - cancer	Stem Cell Exhaustion	In human CRC tissues, SNAIL regulates expression of IL-8 and other genes to induce cancer stem cell activities.	21640118
Specialty Type - cancer	Stem Cell Exhaustion	Some cancer cells have activities that are similar to those of stem cells from normal tissues, and cell dedifferentiation correlates with poor prognosis.	21640118
Specialty Type - cancer, Malignant tumor of colon, Neoplasms	Stem Cell Exhaustion	Expanded CRC colonospheres contained cells that expressed high levels of CD44 and CD166, which are markers of colon cancer stem cells, and had many features of cancer stem cells, including chemoresistance and radioresistance, the ability to initiate tumor formation, and activation of epithelial-mesenchymal transition (EMT).	21640118
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Strategies that disrupt this pathway might be developed to block tumor formation by cancer stem cells.	21640118
Pruritus	Stem Cell Exhaustion	The patient's pruritus markedly improved within 2 cycles of chemotherapy; however, his HL relapsed and additional salvage combination chemotherapy followed by high-dose chemotherapy and autologous stem cell transplant were required.	21644488
Pericardial Effusion, CTCAE, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Differential diagnosis of pericardial effusion after stem cell transplantation in acute myeloic leukemia.	21647784
Pericardial Effusion, CTCAE, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The pathology underlying a pericardial effusion in a 24-year-old patient, who had suffered from acute myeloic leukemia 5 years previously and undergone chemotherapy followed by whole body radiation prior to allogeneic stem cell transplantation, could be identified by the careful analysis of pericardial cytology and epicardial biopsy guided by flexible pericardioscopy.	21647784
Multiple Myeloma	Stem Cell Exhaustion	Predicting hematopoietic stem cell mobilization failure in patients with multiple myeloma: a simple method using day 1 CD34+ cell yield.	21647951
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Early and reliable prediction of the likelihood of achieving adequate stem cell collection for autologous stem cell transplantation (ASCT) in patients with multiple myeloma (MM) would improve collection efficiency, prevent unnecessary aphereses, and permit appropriate treatment alterations.	21647951
Irritation, Keratopathy, Rupture, Usual Severity Pain	Stem Cell Exhaustion	Most common complications included injection (n=13), tearing (n=10), irritation (n=9), pain (n=9), and limbal stem cell deficiency with keratopathy (n=4).	21652078
HD Term Type, Chemosensitivity	Stem Cell Exhaustion	This randomized open phase III study examines whether high-dose (HD) chemotherapy with peripheral blood stem cells (PBSCs) could improve overall survival (OS) of chemosensitive patients.	21652583
melphalan/prednisone protocol, Multiple Myeloma	Stem Cell Exhaustion	As part of the randomized MRC Myeloma IX trial, we compared an attenuated regimen of cyclophosphamide, thalidomide, and dexamethasone (CTDa; n = 426) with melphalan and prednisolone (MP; n = 423) in patients with newly diagnosed multiple myeloma ineligible for autologous stem-cell transplantation.	21652683
Renal glomerular disease, Myeloproliferative disease	Stem Cell Exhaustion	Myeloproliferative neoplasms are clonal hematopoietic stem cell disorders that can produce an undefined glomerulopathy.	21654720
Hypertensive (finding), Electrocardiogram: left ventricle hypertrophy (finding)	Stem Cell Exhaustion	Decreased circulating endothelial progenitor cell levels and function in essential hypertensive patients with electrocardiographic left ventricular hypertrophy.	21654753
Left Ventricular Hypertrophy, Hypertensive (finding), Electrocardiogram: left ventricle hypertrophy (finding)	Stem Cell Exhaustion	The aim of this study was to explore the role of circulating endothelial progenitor cells (EPCs) and endothelial apoptotic microparticles in hypertensive patients with and without electrocardiographic left ventricular hypertrophy (LVH).	21654753
Endothelial dysfunction	Stem Cell Exhaustion	Angiotensin II (Ang II) is essential for endothelial progenitor cells (EPCs) function as Ang-II-induced oxidative stress causes senescence of EPCs and endothelial dysfunction and Ang II type 1 receptor blockers increase EPCs.	21654754
Sjogrens Syndrome	Stem Cell Exhaustion	Comparison of telomere length and association with progenitor cell markers in lacrimal gland between Sjogren syndrome and non-Sjogren syndrome dry eye patients.	21655359
Sjogrens Syndrome	Stem Cell Exhaustion	The aims of this study were to 1) determine the viability of quantitative fluorescence in situ hybridization of telomeres (telo-FISH) for the assessment of telomere length in lacrimal gland in Sjogren and non- Sjogren syndrome patients; and 2) investigate the relationship between progenitor cell markers and telomere length in both groups.	21655359
Sui Chinese, Urinary Stress Incontinence	Stem Cell Exhaustion	Stem-cell injection into the degenerated external urethral sphincter is a new treatment modality for stress urinary incontinence (SUI).	21656833
Urinary Stress Incontinence	Stem Cell Exhaustion	Long-term cryopreservation of pyramidalis muscle specimens as a source of striated muscle stem cells for treatment of post-prostatectomy stress urinary incontinence.	21656833
Sui Chinese	Stem Cell Exhaustion	We examined the possibility of long-term cryopreserved pyramidalis muscle (PM) specimens as a source of striated muscle stem cells for the treatment of post-prostatectomy SUI.	21656833
Multiple Myeloma	Stem Cell Exhaustion	Predictive factors for successful salvage high-dose therapy in patients with multiple myeloma relapsing after autologous blood stem cell transplantation.	21657961
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	For patients with relapsed or refractory multiple myeloma (MM) treated with a prior high-dose therapy (HDT) followed by autologous peripheral blood stem cell transplantation (PBSCT), the reapplication of HDT is a widely used salvage strategy.	21657961
Childhood Non-Hodgkin Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Plerixafor was recently approved for stem cell mobilization in patients who have non-Hodgkin lymphoma or multiple myeloma.	21658654
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Of 48 patients, including 24 with myeloma and 24 with lymphoma, 47 had enough stem cells collected (> 2 x 10E6 CD34+ cells/kg) to proceed to transplant, including all 13 patients who had failed previous chemotherapy plus G-CSF mobilization and 18 patients treated with four cycles or more of lenalidomide.	21658654
Hematologic Neoplasms, Aspergillosis	Stem Cell Exhaustion	Outcome analysis of invasive aspergillosis in hematologic malignancy and hematopoietic stem cell transplant patients: the role of novel antimold azoles.	21659609
Multiple Myeloma	Stem Cell Exhaustion	A randomized trial with melphalan and prednisone versus melphalan and prednisone plus thalidomide in newly diagnosed multiple myeloma patients not eligible for autologous stem cell transplant.	21663513
Infarction	Stem Cell Exhaustion	Impact of preoperative left ventricular function and time from infarction on the long-term benefits after intramyocardial CD133(+) bone marrow stem cell transplant.	21664627
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Preoperative left ventricular ejection fraction and time since myocardial infarction may be critical parameters for selection of patients who can benefit most from intramyocardial stem cell treatment during coronary artery bypass grafting.	21664627
Bone Marrow-Derived Cell, Dendritic Cell Sarcoma, Interdigitating, Neoplasms, histiocytic	Stem Cell Exhaustion	Histiocytic and interdigitating dendritic cell sarcomas are rare tumors originating from bone marrow-derived myeloid stem cells.	21666687
Acute leukemia, Lymphoproliferative Disorders	Stem Cell Exhaustion	Acute leukaemia (34.6%) and allogeneic stem cell transplantation (21.4%) were major host factors, together with chronic lymphoproliferative disorders (21.6%), which emerged as a new high-risk group.	21668573
Acute leukemia	Stem Cell Exhaustion	Serum galactomannan tests were more often positive (>=69%) for acute leukaemia and allogeneic stem cell transplantation than for the others (<42%; p <10(-3)).	21668573
Burn injury	Stem Cell Exhaustion	Long-term effectiveness of autologous cultured limbal stem cell grafts in patients with limbal stem cell deficiency due to chemical burns.	21668791
Burn injury, Abnormal vision, Corneal Opacity	Stem Cell Exhaustion	Chemical burns cause depletion of limbal stem cells and eventually lead to corneal opacity and visual loss.	21668791
Antilymphocyte Serum	Stem Cell Exhaustion	Optimization of immunosuppressive therapy for spinal grafting of human spinal stem cells in a rat model of ALS.	21669047
Antilymphocyte Serum	Stem Cell Exhaustion	In the present study we characterized the survival of human spinal stem cells when grafted into the lumbar spinal cords of a rodent model of ALS, SOD1 (G93A) male and female rats (60-67 days old).	21669047
Liver carcinoma	Stem Cell Exhaustion	Hepatocellular carcinoma with progenitor cell features distinguishable by the hepatic stem/progenitor cell marker NCAM.	21669487
Liver carcinoma, Hollings Cancer Center	Stem Cell Exhaustion	We analyzed hepatocellular carcinoma (HCC) with progenitor cell features using hepatic stem/progenitor cell marker neural cell adhesion molecule (NCAM).	21669487
CLU protein, human	Stem Cell Exhaustion	However, most patients with Fontaine stage IV CLI limbs had to undergo amputation even after stem cell therapy.	21671823
Cartilaginous exostosis	Stem Cell Exhaustion	Expression of the stem cell marker nestin in pre/hypertrophic chondrocytes in osteochondroma.	21672338
Pregnancy Complications, Infectious, Multiple Myeloma	Stem Cell Exhaustion	Prophylactic intravenous immunoglobulin during autologous haemopoietic stem cell transplantation for multiple myeloma is not associated with reduced infectious complications.	21674144
Pregnancy Complications, Infectious, Multiple Myeloma	Stem Cell Exhaustion	Patients with multiple myeloma undergoing autologous haemopoietic stem cell transplantation (ASCT) are at high risk for infectious complications.	21674144
Specialty Type - cancer	Stem Cell Exhaustion	Recent data showed that prostate stem cell antigen (PSCA) mRNA expression is predictive of the subsequent cancer in BPH patients treated with TURP.	21674503
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	The introduction of plerixafor has enabled successful collection of stem cells in the majority of patients with lymphoma or myeloma in whom previous attempts at mobilization have failed.	21674573
Bacteremia	Stem Cell Exhaustion	In the retrospective survey Gram-negative bacteremic episodes occurring in a centre for hematology and stem cell transplantation were studied.	21676672
Aplastic Anemia	Stem Cell Exhaustion	Effect of stem cell source on outcomes after unrelated donor transplantation in severe aplastic anemia.	21677312
Childhood Breast Carcinoma	Stem Cell Exhaustion	Breast cancer stem cell markers CD44, CD24 and ALDH1: expression distribution within intrinsic molecular subtype.	21680574
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	The study of CD44/CD24 and ALDH1 expression is the most accurate method to identify cancer stem cells (CSC) from breast cancer populations.	21680574
Uremia	Stem Cell Exhaustion	Exposure to uremic serum induces a procalcific phenotype in human mesenchymal stem cells.	21680902
Chronic Kidney Disease, CTCAE	Stem Cell Exhaustion	The current study is based on the hypothesis that mesenchymal stem cells (MSC) constitute critical cells for procalcific extracellular matrix remodeling in patients with chronic kidney disease.	21680902
Specialty Type - cancer	Stem Cell Exhaustion	There is compelling evidence that blood-borne tissue factor that is predominantly found on circulating microparticles (MPs) plays an important role in both, cancer biology and organ and stem-cell transplantation (SCT).	21681142
Hypertrophy, Acute myocardial infarction	Stem Cell Exhaustion	Maladaptive hypertrophy after acute myocardial infarction positive effect of bone marrow-derived stem cell therapy on regional remodeling measured by cardiac MRI.	21681619
Hypertrophy	Stem Cell Exhaustion	Bone marrow-derived stem cell therapy yields smaller EDWT when compared with placebo patients suggesting a positive effect on maladaptive hypertrophy of viable myocardium.	21681619
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study.	21681681
Chronic disease, Diabetes	Stem Cell Exhaustion	Mesenchymal stem cells (MSC) have been used in clinical trials for severe diabetes, a chronic disease with high morbidity and mortality.	21681681
physiopathological	Stem Cell Exhaustion	Relationships between vascular dysfunction, circulating endothelial progenitor cells, and psychological status in healthy subjects.	21681866
Communicable Diseases	Stem Cell Exhaustion	Vascular endothelial growth factor levels in the media from infected urine derived stem cell cultures reached a peak value on day 10 after infection.	21683398
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Platelet recovery before allogeneic stem cell transplantation predicts posttransplantation outcomes in patients with acute myelogenous leukemia and myelodysplastic syndrome.	21684343
Hematologic Neoplasms	Stem Cell Exhaustion	Twenty-four patients with hematologic malignancies (16 high risk) conditioned with fludarabine, cyclophosphamide, and totalbody irradiation received a CD34-selected stem cell allograft from an HLA-matched sibling along with 5 x 10(6)/kg selectively depleted donor T cells.	21684344
Medulloblastoma	Stem Cell Exhaustion	Medulloblastoma with myogenic differentiation: long-term survival in a patient treated with aggressive combination therapy and autologous stem cell transplantation.	21688181
Communicable Diseases	Stem Cell Exhaustion	Cytomegalovirus (CMV) infection and disease are important complications after hematopoietic stem cell transplant, particularly after transplant from alternative donors.	21689774
Multiple Myeloma	Stem Cell Exhaustion	Lenalidomide maintenance after nonmyeloablative allogeneic stem cell transplantation in multiple myeloma is not feasible: results of the HOVON 76 Trial.	21690556
Multiple Myeloma	Stem Cell Exhaustion	To improve the outcome of allogeneic stem cell transplantation (allo-SCT) in multiple myeloma as part of first-line treatment, we prospectively investigated the feasibility and efficacy of lenalidomide maintenance.	21690556
Multiple Myeloma	Stem Cell Exhaustion	Trends in allogeneic stem cell transplantation for multiple myeloma: a CIBMTR analysis.	21690560
Malignant neoplasm of ovary	Stem Cell Exhaustion	Small interfering RNA knockdown experiments and MTS assays were used to evaluate CPE-induced cytotoxicity against ovarian cancer stem cell lines in vitro.	21692061
Malignant neoplasm of ovary	Stem Cell Exhaustion	C.B-17/SCID mice harboring ovarian cancer stem cell xenografts were used to evaluate CPE therapeutic activity in vivo.	21692061
Malignant neoplasm of ovary, Clostridium perfringens	Stem Cell Exhaustion	Eradication of chemotherapy-resistant CD44+ human ovarian cancer stem cells in mice by intraperitoneal administration of Clostridium perfringens enterotoxin.	21692061
Neoplasms, Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Emerging evidence has suggested that the capability to sustain tumor formation, growth, and chemotherapy resistance in ovarian as well as other human malignancies exclusively resides in a small proportion of tumor cells termed cancer stem cells.	21692061
Malignant neoplasm of ovary	Stem Cell Exhaustion	During the characterization of CD44(+) ovarian cancer stem cells, we found a high expression of the genes encoding for claudin-4.	21692061
Malignant neoplasm of ovary, Clostridium perfringens	Stem Cell Exhaustion	Because this tight junction protein is the natural high-affinity receptor for Clostridium perfringens enterotoxin (CPE), we have extensively investigated the sensitivity of ovarian cancer stem cells to CPE treatment in vitro and in vivo.	21692061
Malignant neoplasm of ovary	Stem Cell Exhaustion	Real-time polymerase chain reaction and flow cytometry were used to evaluate claudin-3/-4 expression in ovarian cancer stem cells.	21692061
Malignant neoplasm of ovary	Stem Cell Exhaustion	CD44(+) ovarian cancer stem cells expressed claudin-4 gene at significantly higher levels than matched autologous CD44(-) ovarian cancer cells, and regardless of their higher resistance to chemotherapeutic agents died within 1 hour after exposure to 1.0 mg/mL of CPE in vitro.	21692061
Specialty Type - cancer	Stem Cell Exhaustion	Conversely, small-interfering RNA-mediated knockdown of claudin-3/-4 expression in CD44(+) cancer stem cells significantly protected cancer stem cells from CPE-induced cytotoxicity.	21692061
Neoplasms	Stem Cell Exhaustion	Importantly, multiple intraperitoneal administrations of sublethal doses of CPE in mice harboring xenografts of chemotherapy-resistant CD44(+) ovarian cancer stem cells had a significant inhibitory effect on tumor progression leading to the cure and/or long-term survival of all treated animals (ie, 100% reduction in tumor burden in 50% of treated mice; P < .0001).	21692061
Ulcer	Stem Cell Exhaustion	Clinically shows the high efficiency of the transplantations autologous mesenchymal stem cells in treatment of deep beam ulcers, intractable standard conservative treatment.	21692224
Radiation injury	Stem Cell Exhaustion	Found promising application of mesenchymal stem cells for treatment of severe local radiation injuries and the need to develop the best possible conditions for their use.	21692224
Specialty Type - cancer	Stem Cell Exhaustion	Patients without surgery (n = 111), with stem cell transplantation (n = 98), unknown or non-standard chemotherapy regimens (n = 94), lost to follow up (n = 66) or 'cancer status unknown' (n = 67) were excluded.	21693006
Graft-vs-Host Disease	Stem Cell Exhaustion	Correlation between the kinetics of CD3+ chimerism and the incidence of graft-versus-host disease in patients undergoing allogeneic hematopoietic stem cell transplantation.	21693300
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GvHD) remains a significant complication after allogeneic hematopoietic stem cell transplantation (HSCT).	21693300
Acute GVH disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Upon univariate analysis, decreasing mixed chimerism among CD3(+) and infused CD34(+) cell numbers was significantly correlated with acute GvHD development, while the PB stem cell source, reduced-intensity conditioning regimen, and female donor sex were associated with an increased risk of chronic GvHD.	21693300
Diabetic Foot, Peripheral Arterial Diseases	Stem Cell Exhaustion	Our study suggests that stem cell therapy of diabetic foot disease is an effective therapeutic option with no adverse events for patients with severe peripheral arterial disease.	21695925
Ischemia, Diabetic Foot	Stem Cell Exhaustion	[Treatment of critical limb ischemia and diabetic foot disease by the use of autologous stem cells].	21695925
Ischemia	Stem Cell Exhaustion	The aim of our study was to assess safety and effectiveness of therapy of critical limb ischaemia by autologous stem cells and evaluation of potential adverse events.	21695925
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Stem cell transplantation is a potential treatment to improve left ventricular ejection fraction (LVEF) after ST elevation myocardial infarction (STEMI).	21696072
Multiple Myeloma	Stem Cell Exhaustion	Thalidomide, dexamethasone and lovastatin with autologous stem cell transplantation as a salvage immunomodulatory therapy in patients with relapsed and refractory multiple myeloma.	21698395
Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	Previous reports suggest that nestin-expressing hair follicle stem cells are undifferentiated and pluripotent, and nestin expression in some tumors indicates poor differentiation and high grade of malignancy.	21700534
Cerebral Infarction, diabetic	Stem Cell Exhaustion	Comparison of the effect of cilostazol with aspirin on circulating endothelial progenitor cells and small-dense LDL cholesterol in diabetic patients with cerebral ischemia: a randomized controlled pilot trial.	21701082
Cardiovascular Diseases	Stem Cell Exhaustion	We compared the effects of cilostazol with aspirin on circulating endothelial progenitor cells (EPCs), a surrogate marker for cardiovascular disease, and lipid metabolism in a randomized controlled trial (UMIN000000537).	21701082
Bronchiolitis Obliterans	Stem Cell Exhaustion	Endothelin-1 governs proliferation and migration of bronchoalveolar lavage-derived lung mesenchymal stem cells in bronchiolitis obliterans syndrome.	21701423
Cerebellar Diseases	Stem Cell Exhaustion	Brain stem cell and cerebellum dysfunction is thought to be due to an autoimmune mechanism.	21702171
Diabetic Retinopathy	Stem Cell Exhaustion	Erythropoietin receptor positive circulating progenitor cells and endothelial progenitor cells in patients with different stages of diabetic retinopathy.	21703113
GDC Disease Response Terminology, diabetic	Stem Cell Exhaustion	EPOR positive circulating progenitor cells (CPCs: CD34(+)) and endothelial progenitor cells (EPCs: CD34(+)KDR(+)) were assessed by flow cytometry in type 2 diabetic patients with different stages of DR.	21703113
Heart failure	Stem Cell Exhaustion	Effects of age and heart failure on human cardiac stem cell function.	21703415
Heart failure, Congestive heart failure	Stem Cell Exhaustion	Currently, it is unknown whether defects in stem cell growth and differentiation contribute to myocardial aging and chronic heart failure (CHF), and whether a compartment of functional human cardiac stem cells (hCSCs) persists in the decompensated heart.	21703415
Allogeneic Hematopoietic Stem Cell Transplantation, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Extramedullary relapse of acute myelogenous leukemia after allogeneic hematopoietic stem cell transplantation: better prognosis than systemic relapse.	21703975
Graft-vs-Host Disease	Stem Cell Exhaustion	Because of its ability to target CD20(+) lymphocytes, its use before allogeneic stem cell transplantation seemed to reduce risk of graft-vs.-host disease (GVHD) occurrence.	21703987
Lymphoproliferative Disorders	Stem Cell Exhaustion	We retrospectively analyzed the outcomes of adult patients diagnosed with CD20(+) lymphoproliferative disease undergoing allogeneic stem cell transplantation and receiving, or not receiving, rituximab up to 3 months before transplantation.	21703987
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders primarily seen in the elderly that are characterized by ineffective hematopoiesis and a propensity to develop AML.	21704372
Communicable Diseases, Mycoses	Stem Cell Exhaustion	We investigated the efficacy of infection control measures on the frequency of fungal infection among hemato-oncologic patients undergoing stem cell transplantation during excavation and construction work of an adjacent hospital building.	21704432
B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1, BCR gene	Stem Cell Exhaustion	Intermediate dose of imatinib in combination with chemotherapy followed by allogeneic stem cell transplantation improves early outcome in paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (ALL): results of the Spanish Cooperative Group SHOP studies ALL-94, ALL-99 and ALL-2005.	21707583
Specialty Type - cancer, F9 wt Allele	Stem Cell Exhaustion	Moreover, human PTC cell line BCPAP and cancer stem cells from PTC, analyzed under hypoxic conditions, showed a hypoxia-driven increase in ER-a expression.	21707866
Acute myocardial infarction	Stem Cell Exhaustion	Enhanced mobilization of the bone marrow-derived circulating progenitor cells by intracoronary freshly isolated bone marrow cells transplantation in patients with acute myocardial infarction.	21707914
Acute myocardial infarction	Stem Cell Exhaustion	We analysed in a randomized controlled study the influence of the intracoronary autologous freshly isolated BMCs-Tx on the mobilization of bone marrow-derived circulating progenitor cells (BM-CPCs) in patients with acute myocardial infarction (AMI).	21707914
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Aldehyde dehydrogenase 1 (ALDH1) has been characterised as a cancer stem cell marker in different types of tumours.	21708005
Ischemic stroke	Stem Cell Exhaustion	CDP-choline treatment increases circulating endothelial progenitor cells in acute ischemic stroke.	21708065
Ischemic stroke	Stem Cell Exhaustion	The increase in circulating endothelial progenitor cells (EPCs) is associated with a better outcome in patients with acute ischemic stroke.	21708065
Venoocclusive disease	Stem Cell Exhaustion	The incidence of veno-occlusive disease following allogeneic hematopoietic stem cell transplantation has diminished and the outcome improved over the last decade.	21708110
Venoocclusive disease	Stem Cell Exhaustion	The evolution of the incidence, morbidity, and mortality of veno-occlusive disease (VOD) was analyzed in 845 allogeneic hematopoietic stem cell transplantations (allo-HSCTs) performed over 24 years.	21708110
Fever, Multiple Myeloma, Adverse Event Associated with Constitutional Symptoms	Stem Cell Exhaustion	A 45 year old male presented with IgA multiple myeloma s/p (status post) autologous hematopoietic stem cell transplantation; and with a history of six weeks of fever and constitutional symptoms.	21713352
Precursor T cell lymphoblastic leukemia/lymphoblastic lymphoma	Stem Cell Exhaustion	High single-drug activity of nelarabine in relapsed T-lymphoblastic leukemia/lymphoma offers curative option with subsequent stem cell transplantation.	21715318
Acute lymphocytic leukemia	Stem Cell Exhaustion	Extramedullary gastric relapse of acute lymphoblastic leukemia following allogeneic stem cell transplant: staging with F-18 FDG PET/CT.	21716008
Gastric mucosa, Acute leukemia	Stem Cell Exhaustion	A 26-year-old man with a prior history of acute leukemia that was treated with a stem cell transplant (SCT) was referred for an F-18 FDG PET/CT to assess suspicious new gastric mucosal lesions.	21716008
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The p53 antisense oligonucleotide cenersen has been shown to sensitize acute myeloid leukemia (AML) stem cells to DNA damaging agents.	21717444
Childhood Breast Carcinoma	Stem Cell Exhaustion	Loss of p16 expression is associated with the stem cell characteristics of surface markers and therapeutic resistance in estrogen receptor-negative breast cancer.	21717460
Childhood Breast Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	The loss of p16 expression may thus reduce the response of ER-negative breast cancer cells to chemotherapy by conferring cancer stem cell-like properties.	21717460
Liver Regeneration	Stem Cell Exhaustion	The declining hepatic progenitor cell population might be one of the reasons for impaired liver regeneration in aged donors.	21719061
Coronary Arteriosclerosis	Stem Cell Exhaustion	Darbepoetin improves endothelial function and increases circulating endothelial progenitor cell number in patients with coronary artery disease.	21719555
palladium	Stem Cell Exhaustion	To date, stem cell transplantation therapy has been developed to replace lost or damaged neural cells in PD patients, in whom dopaminergic neuron cells are lost.	21720700
Medulloblastoma	Stem Cell Exhaustion	Growth-inhibitory effect of neurotrophin-3-secreting adipose tissue-derived mesenchymal stem cells on the D283-MED human medulloblastoma cell line.	21720807
Neoplasms	Stem Cell Exhaustion	The purpose of this study was to demonstrate in vitro biological effects of neurotrophins-3 (NT-3) on MBL cells and to evaluate the growth-inhibitory effect of neurotrophin-3 (NT-3)-secreting stem cells on tumor cells.	21720807
FCER2 gene	Stem Cell Exhaustion	The median event-free survival in patients treated with autologous stem cell transplantation (n = 29) was similar regardless of CD23 status, whereas the median OS (all patients) was longer in CD23(-) than in CD23(+) PCMs: not reached vs 3365 days (P = .08).	21724429
Gastrointestinal complication	Stem Cell Exhaustion	Early gastrointestinal complications of stem cell transplant - results of prospective study at IRCH, AIIMS, India.	21724528
Gastrointestinal complication	Stem Cell Exhaustion	The study was conducted with the purpose of finding clinical profile of early gastrointestinal complications of stem cell transplant at this center.	21724528
Inflammation	Stem Cell Exhaustion	Exercise training improved FMD and exercise capacity in stable CAD patients independent of the changes in inflammation, oxidative stress, or endothelial progenitor cells.	21724681
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Therapeutic resistance of acute myeloid leukemia stem cells, enriched in the CD34(+)38(-)123(+) progenitor population, is supported by extrinsic factors such as the bone marrow niche.	21725365
Specialty Type - cancer, Adult Glioblastoma, Neoplasms, Hypoxia	Stem Cell Exhaustion	We recently described a three-layer concentric model of a glioblastoma (GBM) related to a specific distribution of molecular and phenotypic characteristics driven by the intratumoral hypoxic gradient in which the cancer stem cells niche is located in the hypoxic necrotic core of the tumour.	21725802
Mucositis following radiation therapy	Stem Cell Exhaustion	This study seeks to investigate the use of extra-orally applied near-infrared phototherapy for the reduction of oral pain secondary to chemotherapy- and radiation therapy-induced mucositis in adult and pediatric hematopoietic stem cell transplant (HSCT) patients.	21725826
Multiple Myeloma	Stem Cell Exhaustion	Tandem autologous/reduced-intensity conditioning allogeneic stem-cell transplantation versus autologous transplantation in myeloma: long-term follow-up.	21730266
Multiple Myeloma	Stem Cell Exhaustion	Results of allogeneic stem-cell transplantation (allo) in myeloma are controversial.	21730266
Multiple Myeloma	Stem Cell Exhaustion	In this trial autologous stem-cell transplantation (auto) followed by reduced-intensity conditioning matched sibling donor allo (auto-allo) was compared with auto only in previously untreated multiple myeloma.	21730266
Mantle cell lymphoma, Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Stem Cell Exhaustion	Mantle cell lymphoma international prognostic index but not pretransplantation induction regimen predicts survival for patients with mantle-cell lymphoma receiving high-dose therapy and autologous stem-cell transplantation.	21730271
Medial collateral ligament, Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Stem Cell Exhaustion	High-dose therapy (HDT) and autologous stem-cell transplantation (ASCT) are frequently used in an attempt to improve outcome in patients with mantle-cell lymphoma (MCL); however, the importance of intensive induction regimens before transplantation is unknown.	21730271
Hematologic Neoplasms	Stem Cell Exhaustion	Busulfan is a bifunctional alkylating agent widely used in pretransplant conditioning regimens in patients undergoing stem cell transplantation for hematologic malignancies.	21730282
Sarcoma	Stem Cell Exhaustion	Human sarcomas have been modeled in mice by expression of specific fusion genes in mesenchymal stem cells (MSCs).	21732477
Communicable Diseases, Acute leukemia	Stem Cell Exhaustion	Comparison of the occurrence of mold infection among patients receiving chemotherapy for acute leukemia versus patients undergoing stem cell transplantation.	21732981
PAFAH1B1 wt Allele, Acute leukemia	Stem Cell Exhaustion	We performed a single-center retrospective analysis examining both adult patients treated with chemotherapy for acute leukemia or MDS and patients undergoing allogeneic or autologous stem cell transplantation (SCT) between June 2007 and August 2009.	21732981
Pulmonary arterial hypertension	Stem Cell Exhaustion	Design and validation of an endothelial progenitor cell capture chip and its application in patients with pulmonary arterial hypertension.	21735044
Enlargement procedure, Paraproteinemias	Stem Cell Exhaustion	After high dose chemotherapy with autologous peripheral stem cell transplantation, his clinical manifestations, IgG lambda type monoclonal proteinemia, and elevated level of serum VEGF were improved, whereas diffuse enlargement of the pancreas did not change.	21735734
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Idiotype immunization following high-dose therapy and autologous stem cell transplantation for non-Hodgkin lymphoma.	21736867
Parkinson Disease	Stem Cell Exhaustion	Comparison of endothelial progenitor cells in Parkinson's disease patients treated with levodopa and levodopa/COMT inhibitor.	21738693
Lymphoma, Follicular	Stem Cell Exhaustion	Durable event-free survival following autologous stem cell transplant for relapsed or refractory follicular lymphoma: positive impact of recent rituximab exposure and low-risk Follicular Lymphoma International Prognostic Index score.	21740097
Lymphoma, Follicular	Stem Cell Exhaustion	Published studies have provided conflicting results regarding the curative potential of high dose chemotherapy and autologous stem cell transplant (HDT/ASCT) for follicular lymphoma (FL).	21740097
MYELODYSPLASTIC SYNDROME, Therapy-Related Acute Myeloid Leukemia	Stem Cell Exhaustion	Allogeneic stem cell transplantation in therapy-related acute myeloid leukemia and myelodysplastic syndromes: impact of patient characteristics and timing of transplant.	21740299
Therapy-related myelodysplastic syndrome, MYELODYSPLASTIC SYNDROME, Therapy-Related Acute Myeloid Leukemia	Stem Cell Exhaustion	Patients with therapy-related acute myeloid leukemia (t-AML) and myelodysplastic syndromes (t-MDS) have poor survival and high non-relapse mortality (NRM) after allogeneic stem cell transplantation.	21740299
Acute myocardial infarction	Stem Cell Exhaustion	Endothelin-1 levels predict endothelial progenitor cell mobilization after acute myocardial infarction.	21741393
Acute myocardial infarction	Stem Cell Exhaustion	Endothelin-1 (ET-1), circulating endothelial cells (CEC) and endothelial progenitor cells (EPC) are well-known modulators of endothelial function with important cardiac effects after an acute myocardial infarction.	21741393
Adenoviruses, Human	Stem Cell Exhaustion	High lethality of human adenovirus disease in adult allogeneic stem cell transplant recipients with high adenoviral blood load.	21742548
Infection	Stem Cell Exhaustion	Human adenoviruses (HAdV) can cause disseminated disease as a severe complication after haematopoietic stem cell transplantation (SCT) and may originate from the reactivation of latent infections.	21742548
leukemia, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Role of HCT-comorbidity index, age and disease status at transplantation in predicting survival and non-relapse mortality in patients with myelodysplasia and leukemia undergoing reduced-intensity-conditioning hemopoeitic progenitor cell transplantation.	21743502
Multiple Myeloma	Stem Cell Exhaustion	Treatment of multiple myeloma patients with autologous stem cell transplantation - a fresh analysis.	21744324
Multiple Myeloma	Stem Cell Exhaustion	High dose chemotherapy followed by autologous stem cell transplantation (ASCT), first introduced in the mid-1980s, is now considered the standard therapy for almost all patients with multiple myeloma, because it prolongs overall survival and disease free survival.	21744324
Multiple Myeloma	Stem Cell Exhaustion	The level of minimal residual disease in the bone marrow of patients with multiple myeloma before high-dose therapy and autologous blood stem cell transplantation is an independent predictive parameter.	21745451
Graft-vs-Host Disease	Stem Cell Exhaustion	Corticosteroid refractory graft-versus-host disease (GVHD) is one of the major challenges in the management of allogeneic stem cell transplant recipients.	21745454
Childhood Breast Carcinoma, S100A4 protein, human	Stem Cell Exhaustion	The results of this study suggest that, following malignant transformation, breast cancer stem/progenitor cells retain their stem cell functions and relative frequencies.	21748247
Childhood Breast Carcinoma	Stem Cell Exhaustion	The process by which breast cancer stem cells arise is unknown.	21748247
Neoplasms	Stem Cell Exhaustion	Genetic mutations in the PIK/AKT pathway were found in 73% of the tumors' stem cells, specifically within two subpopulations.	21748247
Childhood Breast Carcinoma	Stem Cell Exhaustion	In this study, we collected and compared benign and malignant breast stem/progenitor cells to determine whether specific genetic abnormalities occur in breast cancer stem/progenitor cells within the human body.	21748247
Pneumonia	Stem Cell Exhaustion	Use of a novel virus detection assay to identify coronavirus HKU1 in the lungs of a hematopoietic stem cell transplant recipient with fatal pneumonia.	21749586
Lupus Erythematosus, Pulmonary Infiltrate, Hypoxemia	Stem Cell Exhaustion	A 38-year-old female patient with systemic lupus erythematosus presented with pulmonary infiltrates and hypoxemia for several months following immunodepleting autologous hematopoietic stem cell transplantation.	21749586
Aspergillosis	Stem Cell Exhaustion	Low incidence of invasive aspergillosis in allogeneic stem cell transplant recipients receiving amphotericin B inhalation prophylaxis.	21749589
Aspergillosis	Stem Cell Exhaustion	In this retrospective study we evaluated the impact of amphotericin B (AmB) deoxycholate inhalation prophylaxis on invasive aspergillosis (IA) in 611 allogeneic stem cell transplant (alloSCT) recipients and their tolerance of the inhalations.	21749589
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation with thiotepa, busulfan, and cyclophosphamide (TBC) conditioning in patients with CNS involvement by non-Hodgkin lymphoma.	21749848
Graft-vs-Host Disease	Stem Cell Exhaustion	Mycophenolate mofetil (MMF) has been widely used for prophylaxis against graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transplantation (allo-SCT).	21751082
Endometrial Hyperplasia, Carcinoma, Endometrioid	Stem Cell Exhaustion	Firstly to examine the expression characteristics of Musashi (Msi)-1 in fetal endometrium, reproductive normal endometrium, endometrial hyperplasia and endometrioid adenocarcinoma, next, to focus on exploring the possibility that Msi-1 serves as a marker of the endometrial stem cells in-situ.	21751144
Adenocarcinoma	Stem Cell Exhaustion	The high expression of Msi-1 in fetal endometrium and endometrioid adenocarcinoma suggests that Msi-1 positive cells have several characteristics of stem cells, such as high proliferative potentiality and multipotency.	21751144
Mantle cell lymphoma	Stem Cell Exhaustion	High-dose cyclophosphamide and rituximab without stem cell transplant: a feasibility study for low grade B-cell, transformed and mantle cell lymphomas.	21756035
Neoplasms	Stem Cell Exhaustion	Relapse after autologous stem cell transplant for low grade B-cell lymphoma is common secondary to ineffective conditioning and/or tumor autograft contamination.	21756035
Lymphoma	Stem Cell Exhaustion	We investigated high-dose cyclophosphamide and rituximab without stem cell rescue as first-line or salvage therapy in lymphomas.	21756035
Hemorrhagic cystitis	Stem Cell Exhaustion	Clinical profile and outcome of urotheliotropic viral haemorrhagic cystitis following haematopoietic stem cell transplantation: a 7-year tertiary centre analysis.	21756537
CLTC gene, Hemorrhagic cystitis	Stem Cell Exhaustion	Viral haemorrhagic cystitis (HC) is a significant complication after haematopoietic stem cell transplantation (HSCT), with a potential for major morbidity.	21756537
Stanford Cancer Institute, Ulcer	Stem Cell Exhaustion	Prompted by encouraging results obtained using bone marrow stem cells to treat several diseases including chronic wounds, this study examines the use of autologous stem cells from bone marrow to promote the healing of pressure ulcers in patients with SCI.	21756569
Breast Carcinoma	Stem Cell Exhaustion	Hematopoietic progenitor cells (HPCs) in node-negative invasive breast carcinomas: Immunohistochemical analysis and clinico-pathological correlations.	21757299
Childhood Breast Carcinoma	Stem Cell Exhaustion	Using immunohistochemistry, we investigated 603 negative lymph nodes from 51 patients affected by invasive breast cancer (BC) to recognize bone marrow-derived hematopoietic progenitor cells (HPCs).	21757299
Endothelial dysfunction, Uremia	Stem Cell Exhaustion	Vitamin D deficiency is associated with endothelial dysfunction in uremic patients, possibly by the impairment in the number and function of endothelial progenitor cells (EPCs).	21757895
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Gene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML.	21760593
Coronary artery	Stem Cell Exhaustion	To assess the safety and efficacy of the Genous(tm) endothelial progenitor cell (EPC) capturing stent in conjunction with HmG-CoA-reductase inhibitors (statins) to stimulate EPC recruitment, in the treatment of patients with de novo coronary artery lesions.	21763653
Secondary to	Stem Cell Exhaustion	Secondary MGUS was more common in patients after stem cell transplantation than in those who had not undergone such treatment (22.7% vs 1.6%, P < .001).	21765020
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Treatment of FLT3-ITD-positive acute myeloid leukemia relapsing after allogeneic stem cell transplantation with sorafenib.	21767516
FLT3 Internal Tandem Duplication, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Patients with acute myeloid leukemia (AML) and internal tandem duplication of FMS-like tyrosine kinase receptor-3 gene (FLT3-ITD) mutation have poor prognoses and are often treated with allogeneic hematopoietic stem cell transplantation (HSCT).	21767516
Hair follicle structure	Stem Cell Exhaustion	Whether the change is triggered at the level of stem cell differentiation, by cytokine or hormonal influences, gene expression during hair follicle development, a combination of all of these, or an unknown cause is a question that remains to be answered.	21768446
Childhood Breast Carcinoma	Stem Cell Exhaustion	High-dose chemotherapy with autologous hematopoietic stem-cell transplantation in metastatic breast cancer: overview of six randomized trials.	21768454
Childhood Breast Carcinoma	Stem Cell Exhaustion	Substantial interest in supporting high-dose chemotherapy with bone marrow or autologous hematopoietic stem-cell transplantation in the 1980s and 1990s led to the initiation of randomized trials to evaluate its effect in the treatment of metastatic breast cancer.	21768454
Childhood Breast Carcinoma	Stem Cell Exhaustion	We identified six randomized trials in metastatic breast cancer that evaluated high doses of chemotherapy with transplant support versus a control regimen without stem-cell support.	21768454
Childhood Breast Carcinoma	Stem Cell Exhaustion	High-dose chemotherapy with autologous stem-cell support as adjuvant therapy in breast cancer: overview of 15 randomized trials.	21768471
Primary malignant neoplasm	Stem Cell Exhaustion	Adjuvant high-dose chemotherapy (HDC) with autologous hematopoietic stem-cell transplantation (AHST) for high-risk primary breast cancer has not been shown to prolong survival.	21768471
Abdominal Pain, BCR gene, primary disorders	Stem Cell Exhaustion	We report a case of a 4-year-old African-American male with a previous history of ALL and hematopoietic stem cell transplant who presented with decreased arm movement and abdominal pain with relapse of primary disease into the brachial plexus and pancreas.	21768888
Glioblastoma Multiforme Pathway, Glioma	Stem Cell Exhaustion	Expression of glioma stem cell marker CD133 and O6-methylguanine-DNA methyltransferase is associated with resistance to radiotherapy in gliomas.	21769436
Glioblastoma Multiforme Pathway, Malignant Glioma	Stem Cell Exhaustion	In the present study, we investigated the prognostic roles of the O6-methylguanine-DNA methyltransferase (MGMT) gene methylation status, the protein profiles of MGMT, and the glioma stem cell (GSC) marker CD133 in malignant glioma resistance to radiotherapy.	21769436
Systemic Scleroderma, Sample Size Calculation	Stem Cell Exhaustion	To determine the gene expression profile of endothelial cells derived from the endothelial progenitor cells (EPCs) of patients with systemic sclerosis (SSc).	21769840
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation in multiple myeloma and lymphoma: an analysis of factors influencing stem cell collection and hematological recovery.	21779930
Childhood Non-Hodgkin Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation is standard treatment for newly diagnosed younger patients with multiple myeloma and for relapsed or refractory Hodgkin or non-Hodgkin lymphoma.	21779930
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Multiple myeloma patients were older than lymphoma patients but received stem cell transplant up-front as opposed to second line therapy for other patient groups.	21779930
Multiple Myeloma	Stem Cell Exhaustion	Feasibility of autologous hematopoietic stem cell transplant in patients aged >=70 years with multiple myeloma.	21780997
Multiple Myeloma	Stem Cell Exhaustion	Abstract We retrospectively analyzed the outcomes of all consecutive patients with myeloma (n = 84) aged >=70 years who had received autologous hematopoietic stem cell transplant (auto HCT) between July 1999 and June 2010 at our institution.	21780997
Hematological Disease	Stem Cell Exhaustion	This retrospective multicenter report assessed the outcome of 600 patients with hematologic diseases older than 60 years who received reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (allo-HSCT), with the specific aim to compare outcomes of patients between 60 and 65 years old (N = 493) with those older than 65 years (N = 107).	21781949
Anterior myocardial infarction	Stem Cell Exhaustion	Safety and feasibility of combined granulocyte colony stimulating factor and erythropoetin based-stem cell therapy using intracoronary infusion of peripheral blood stem cells in patients with recent anterior myocardial infarction: one-year follow-up of a phase 1 study.	21785174
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	to assess the safety and feasibility of combined granulocyte colony-stimulating factor (G-CSF) and erythropoietin (EPO) based intracoronary peripheral blood stem cells (PBSCs) therapy in patients with recent myocardial infarction (RMI) who had successful reperfusion therapy with drug-eluting stent.	21785174
melanoma	Stem Cell Exhaustion	Embryonic stem-cell-preconditioned microenvironment induces loss of cancer cell properties in human melanoma cells.	21787378
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells (CSCs) play an important role in the recurrence and drug resistance of cancer.	21787767
Neoplasms	Stem Cell Exhaustion	The tumors that arose from purified CD117(+)Lineage(-) cells reproduced the original tumor heterogeneity and could be serially generated, demonstrating the ability to self-renew and to differentiate, two defining properties of stem cells.	21787767
Cytopenia, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Myelodysplastic syndromes encompass a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis, refractory cytopenia and a tendency to progress toward acute myeloid leukemia.	21789382
Chronic myeloproliferative disorder, Polycythemia Vera	Stem Cell Exhaustion	Polycythemia vera (PV) is a clonal myeloproliferative neoplasm (MPN) of hematopoietic stem cells.	21790864
Multiple Myeloma, Lymphoma, Morular Metaplasia of the Endometrium	Stem Cell Exhaustion	We evaluated the safety and efficacy of plerixafor, subsequent to disease-specific chemotherapy followed by granulocyte-colony stimulating factor (G-CSF), in 37 multiple myeloma (MM) or lymphoma patients, who were candidates for autologous stem cell transplantation (ASCT) predicted as poor mobilizers (PMs).	21791194
Lymphoma	Stem Cell Exhaustion	Of the 27 patients rescued with plerixafor, 24 (13 MM, 11 lymphoma) have been transplanted with plerixafor-mobilized peripheral blood stem cells, showing a rapid and durable hematologic recovery.	21791194
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Leukemic stem cell persistence in chronic myeloid leukemia patients with sustained undetectable molecular residual disease.	21791426
leukemia	Stem Cell Exhaustion	It remains unclear whether these patients are definitively cured of their leukemia or whether leukemic stem cells (LSCs) persist in their BM.	21791426
Graft-vs-Host Disease	Stem Cell Exhaustion	From a total cohort (n = 242) of patients surviving more than 100 days after hematopoietic stem cell transplantation, 181 (75% of those at risk) had some manifestations of graft-versus-host disease after day 100.	21791465
Chronic graft-versus-host disease	Stem Cell Exhaustion	We aimed to study the association of the proposed chronic graft-versus-host disease classification and global severity with transplantation outcomes among a consecutive series of patients who received pharmacokinetically-targeted doses of intravenous busulfan and fludarabine conditioning followed by transplantation of allogeneic peripheral blood stem cells.	21791465
Endothelium	Stem Cell Exhaustion	The circulating endothelial progenitor cell (EPC) plays an important role in postnatal vasculogenesis and reduction of endothelial injury.	21793037
Cerebral Aneurysm	Stem Cell Exhaustion	Changes and function of circulating endothelial progenitor cells in patients with cerebral aneurysm.	21793037
Morular Metaplasia of the Endometrium, Malignant Neoplasms	Stem Cell Exhaustion	We calculated standardized incidence rates (SIRs) for all subsequent hematologic and nonhematologic malignancies for MM patients diagnosed before/after 1995 (introduction of high-dose melphalan/autologous stem cell transplantation [HDM-ASCT]) and 2000 (introduction of immunomodulatory drugs [IMiDs]), respectively.	21795746
Specialty Type - cancer	Stem Cell Exhaustion	CD133 is known to be a cancer stem cell (CSC) marker.	21798073
Graft-vs-Host Disease	Stem Cell Exhaustion	We report the case of a 24-year-old patient who underwent a duodenal biopsy due to the suspicion of graft-versus-host disease following allogeneic stem cell transplantation 3 months previously.	21800189
Concomitant Medication Submission Domain	Stem Cell Exhaustion	The identification of cells with properties of retinal progenitor cells (RPCs) in the adult human ciliary margin (CM) prompted a number of studies of their proliferative and differentiation potential.	21801333
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We performed a phase I study of the combination of clofarabine plus melphalan as a reduced-intensity conditioning regimen for allogeneic stem cell transplantation in patients with acute myelogenous leukemia.	21801703
Ductal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Clinicopathologic correlation of cancer stem cell markers CD44, CD24, VEGF and HIF-1a in ductal carcinoma in situ and invasive ductal carcinoma of breast: an immunohistochemistry-based pilot study.	21802218
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	CD24(-/low)CD44(+) cells have been identified as putative cancer stem cells (CSCs) in breast cancer.	21802218
Liver Dysfunction	Stem Cell Exhaustion	The role of ERCP in evaluating patients with hepatobiliary dysfunction after hematopoietic stem cell transplantation (HSCT) has not been well-defined.	21802682
Malignant melanoma of conjunctiva, Ocular Cicatricial Pemphigoid, Stevens-Johnson Syndrome	Stem Cell Exhaustion	Seven patients (7 eyes) with total limbal stem cell deficiency caused by chemical burn (4 eyes), Stevens-Johnson syndrome / toxic epidermal necrolysis (1 eye), ocular cicatricial pemphigoid (1 eye), and multiple cryotherapies and application of mitomycin C for conjunctival melanoma (1 eye) were enrolled in this study.	21803325
Hematologic Neoplasms, Cardiotoxicity	Stem Cell Exhaustion	The current treatment of hematologic malignancies includes diverse potentially cardiotoxic chemotherapy agents, including high-dose myeloablative regimens used in autologous hematopoietic stem cell transplantation (HSCT).	21807325
Degenerative polyarthritis, Osteopenia	Stem Cell Exhaustion	Aging is associated with bone loss and degenerative joint diseases, in which the aging of bone marrow-derived mesenchymal stem cell (bmMSC)[1] may play an important role.	21808097
Disorder of skeletal system	Stem Cell Exhaustion	Gene expression profiling suggests a pathological role of human bone marrow-derived mesenchymal stem cells in aging-related skeletal diseases.	21808097
Globoid cell leukodystrophy	Stem Cell Exhaustion	Neural stem cell gene therapy ameliorates pathology and function in a mouse model of globoid cell leukodystrophy.	21809420
Globoid cell leukodystrophy	Stem Cell Exhaustion	Murine neural stem cells (mNSCs), either naive or genetically modified to express supranormal levels of b-galactocerebrosidase (GALC), were transplanted into the brain of Twitcher mice, a murine model of globoid cell leukodystrophy, a severe sphingolipidosis.	21809420
Peripheral Arterial Diseases	Stem Cell Exhaustion	Controlled-release basic fibroblast growth factor for peripheral artery disease: comparison with autologous bone marrow-derived stem cell transfer.	21810028
Hemorrhagic cystitis	Stem Cell Exhaustion	Different risk factors related to adenovirus- or BK virus-associated hemorrhagic cystitis following allogeneic stem cell transplantation.	21810401
CLTC gene, Hemorrhagic cystitis	Stem Cell Exhaustion	Virus-associated hemorrhagic cystitis (HC) is a major cause of morbidity and mortality following allogeneic hematopoietic stem cell transplantation (HSCT).	21810401
Acute Undifferentiated Leukemia	Stem Cell Exhaustion	Further, corresponding to the morphological changes of nucleolus in number and size, these highly proliferating SSEA1 cells demonstrated coexpression of either D2-40 or the mesodermal marker Scl (stem cell leukemia), brachyury, and Flk-1 (vascular endothelial growth factor-2), respectively, indicative of the neoplasmtic transformation into the stromal or vascular cells.	21811099
Antilymphocyte Serum	Stem Cell Exhaustion	As pharmacological therapies have failed to provide sufficient neuroprotective effects in ALS, transplantation of stem or progenitor cells is considered a promising treatment strategy.	21812628
Antilymphocyte Serum	Stem Cell Exhaustion	We present a 63-year-old male patient suffering from ALS who underwent intramedullary thoracic spinal cord implantation of human CD34(+) umbilical cord-derived haematopoietic progenitor cells with a three-year follow up after transplantation.	21812628
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Efficacy of large doses of IL-2-activated human leukocyte antigen haploidentical peripheral blood stem cells on refractory metastatic renal cell carcinoma.	21812652
Refractory Cytopenia of Childhood	Stem Cell Exhaustion	The aim of this article was to evaluate the clinical efficacy of the infusion of a high dose of interleukin (IL)-2-activated allogeneic haploidentical peripheral blood stem cells (haplo-PBSCs) in patients with advanced intractable RCC.	21812652
Aplastic Anemia, Hematopoietic	Stem Cell Exhaustion	In severe acquired aplastic anemia, hematopoietic failure is the result of immune-mediated destruction of bone marrow stem and progenitor cells.	21812672
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Clinical outcomes of patients with plasma cell leukemia in the era of novel therapies and hematopoietic stem cell transplantation strategies: a single-institution experience.	21813352
Engraftment syndrome	Stem Cell Exhaustion	Cyclophosphamide and prednisone induction followed by cyclophosphamide mobilization effectively decreases the incidence of engraftment syndrome in patients with POEMS syndrome who undergo stem cell transplantation.	21815185
Specialty Type - cancer	Stem Cell Exhaustion	High-dose chemotherapy with autologous stem cell transplantation (ASCT) can achieve excellent clinical responses in patients with POEMS syndrome (Jimenez Zepeda et al., Blood 2010;116:2403; Gertz et al., Am J Hematol 2005;79:319-328; Gherardi et al., Ann Neurol 1994;35:501-505; Gattinoni et al., Nat Rev Immunol 2006;6:383-393; Salem et al., J Immunol 2009;182:2030-2040; Salem et al., Cancer Immunol Immunother 2010;59:341-353; Salem et al., Cell Immunol 2010;261:134-143).	21815185
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Further studies should focus on alternative approaches to using proteasome inhibitors in the treatment of CML, such as in combination with tyrosine kinase inhibitors (TKIs) or as a strategy to eradicate leukemic stem cells.	21816374
Conn Syndrome	Stem Cell Exhaustion	Endothelial progenitor cells in primary aldosteronism: a biomarker of severity for aldosterone vasculopathy and prognosis.	21816781
Arterial Stiffness	Stem Cell Exhaustion	Our objective was to investigate the number and function of endothelial progenitor cells (EPC) in PA and the relationship with arterial stiffness and disease progression.	21816781
Lymphoma	Stem Cell Exhaustion	BeEAM (bendamustine, etoposide, cytarabine, melphalan) before autologous stem cell transplantation is safe and effective for resistant/relapsed lymphoma patients.	21816830
Lymphoma	Stem Cell Exhaustion	We designed a phase 1-2 study to evaluate the safety and the efficacy of increasing doses of bendamustine (160 mg/m2, 180 mg/m2, and 200 mg/m2 given on days -7 and -6) coupled with fixed doses of etoposide, cytarabine, and melphalan (BeEAM regimen) as the conditioning regimen to autologous stem cell transplantation for resistant/relapsed lymphoma patients.	21816830
Inflammatory Bowel Diseases, Dysplasia	Stem Cell Exhaustion	Dysplastic lesions in inflammatory bowel disease show increased positivity for the stem cell marker aldehyde dehydrogenase.	21820149
Inflammatory Bowel Diseases, Specialty Type - cancer, Dysplasia	Stem Cell Exhaustion	To this end, we studied the expression of the cancer stem cell marker aldehyde dehydrogenase to determine whether expression is increased in dysplastic lesions arising in inflammatory bowel disease.	21820149
Inflammatory Bowel Diseases, Specialty Type - cancer, Dysplasia	Stem Cell Exhaustion	Our findings support the hypothesis that dysplasia in inflammatory bowel disease is associated with increased aldehyde dehydrogenase positivity, which supports the cancer stem cell hypothesis.	21820149
Multiple Myeloma	Stem Cell Exhaustion	Allogeneic stem cell transplantation in multiple myeloma relapsed after autograft: a multicenter retrospective study based on donor availability.	21820394
Multiple Myeloma	Stem Cell Exhaustion	Allogeneic stem cell transplantation (allo-SCT) using reduced-intensity conditioning (RIC) is a feasible procedure in selected patients with relapsed multiple myeloma (MM), but its efficacy remains a matter of debate.	21820394
Neoplasms	Stem Cell Exhaustion	We will also review data about stem cells, tumor initiating cells and dormancy state.	21826967
Damage	Stem Cell Exhaustion	Marrow damage from chemo- and radiation therapies has been suggested to affect quality and quantity of hematopoietic stem cell (HSC) products.	21827503
Amyloidosis	Stem Cell Exhaustion	Outcome of AL amyloidosis after high-dose melphalan and autologous stem cell transplantation: long-term results in a series of 421 patients.	21828140
Amyloidosis	Stem Cell Exhaustion	Previous studies have suggested that, in patients with AL amyloidosis treated with high-dose melphalan and autologous stem-cell transplantation (HDM/SCT), the greatest benefit is seen in those patients achieving a hematologic complete response (CR).	21828140
Diabetes, Myocardial Ischemia	Stem Cell Exhaustion	Impaired mobilization of CD133(+) bone marrow-derived circulating progenitor cells with an increased number of diseased coronary arteries in ischemic heart disease patients with diabetes.	21828932
Myocardial Ischemia	Stem Cell Exhaustion	The influence of the number of diseased coronary arteries on the mobilization of CD133/45(+) bone marrow-derived circulating progenitor cells (BM-CPCs) in peripheral blood (PB) in patients with ischemic heart disease (IHD) was analyzed.	21828932
Aggressive course, Specialty Type - cancer	Stem Cell Exhaustion	Podocalyxin-like 1 (PODXL) is a cell-adhesion glycoprotein and stem cell marker that has been associated with an aggressive tumour phenotype and poor prognosis in several forms of cancer.	21829192
Carcinogenesis	Stem Cell Exhaustion	Sequential expression of putative stem cell markers in gastric carcinogenesis.	21829201
Decreased platelet count	Stem Cell Exhaustion	Prognostic significance of delayed thrombocytopenia after allogeneic stem cell transplant.	21830231
Neoplasms	Stem Cell Exhaustion	It is recognized as a rare but life-threatening complication of organ transplantation, tumor eradication chemotherapy and is associated with haematopoietic stem cell transplantation (SCT).	21830430
B-Cell Lymphomas	Stem Cell Exhaustion	A prospective phase II study of RICE re-induction, then high-dose fludarabine and busulfan, followed by autologous or allogeneic blood stem cell transplantation for indolent b-cell lymphoma.	21831743
Lymphoma	Stem Cell Exhaustion	Optimal high dose conditioning and relative roles of autologous stem cell transplantation (autoSCT) or allogeneic (alloSCT) for indolent lymphoma are uncertain.	21831743
SERPINB3 wt Allele, Leukoplakia, Squamous cell carcinoma	Stem Cell Exhaustion	This study examined immunohistochemical expression of DNp63, a keratinocyte stem cell marker, in oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC) and then to elucidate usefulness of DNp63 as a marker for diagnosis and prognosis.	21833468
Childhood Breast Carcinoma, Neoplasms, Secondary Neoplasm, Triple Negative Breast Neoplasms	Stem Cell Exhaustion	We determined that patients with triple-negative tumors had significantly higher incidence of recurrence or distant metastasis associated with increased frequency of breast cancer stem cell phenotypes compared with those with non-triple-negative tumors.	21835433
Neoplasms, Childhood Breast Carcinoma, Primary Neoplasm	Stem Cell Exhaustion	Preclinical studies in FVBN202 transgenic mice confirmed these findings by showing that relapsed tumors were triple negative and had significantly higher frequency of breast cancer stem cells compared with their related primary tumors.	21835433
Childhood Breast Carcinoma	Stem Cell Exhaustion	The importance of CD44(+)/CD24(-/low) (stem/progenitor cell-phenotype) in breast cancer patients has also been appreciated.	21835433
Breast Carcinoma, Specialty Type - cancer, Triple-Negative Breast Cancer Finding	Stem Cell Exhaustion	CD44(+)/CD24(-/low) cancer stem/progenitor cells are more abundant in triple-negative invasive breast carcinoma phenotype and are associated with poor outcome.	21835433
Histogenic Process	Stem Cell Exhaustion	Histogenesis remains controversial, although the consensus tends toward a pluripotent stem cell of the middle ear mucosa as the origin of the lesion.	21838097
Neoplasms, Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	CD44(+) /CD24(-) tumor cells are reported to contain cancer stem cells in breast cancer.	21838786
Hyperlipidemia	Stem Cell Exhaustion	Hyperlipidemia and statin use after allogeneic hematopoietic stem cell transplantation.	21839706
Cardiac complication	Stem Cell Exhaustion	An increased incidence of cardiovascular complications has been documented in recipients of allogeneic hematopoietic stem cell transplantation (HSCT).	21839706
Graft-vs-Host Disease, Enterovirus Gastroenteritis, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We present a 43-year-old individual with large-volume stool output Norovirus acute gastroenteritis in the setting of relapsed refractory acute myelogenous leukemia, hematopoietic stem cell transplantation, and biopsy-proven cutaneous and pulmonary graft-versus-host disease.	21839773
Hematologic Neoplasms	Stem Cell Exhaustion	Patients with hematologic malignancies not in remission before allogeneic hematopoietic stem cell transplantation (HSCT) have a poor prognosis.	21841163
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Complete remission was achieved in 80% of all patients by day +30 and in 100% of AML patients without prior hematopoietic stem cell transplantation.	21841163
Myxoma	Stem Cell Exhaustion	The potential origin from pluripotent mesenchymal cells or from seeded stem cells is hypothesized for glandular differentiation in myxomas.	21843055
Neutropenia	Stem Cell Exhaustion	Disease-specific factors including hematological diagnosis, neutropenia, remission status, prior stem cell transplant, time from diagnosis to admission and degree of prior treatment were not predictive.	21846185
methyldopa	Stem Cell Exhaustion	Neural stem/progenitor cells circulating in peripheral blood of patients with neovascular form of AMD: a novel view on pathophysiology.	21847578
methyldopa	Stem Cell Exhaustion	Our findings suggest that neural progenitor cells, together with low SDF-1 concentrations, may play a considerable role in the process of AMD progression.	21847578
Pure Red-Cell Aplasia, Hemolysis (biological function)	Stem Cell Exhaustion	Major ABO mismatch in hematopoietic progenitor cell transplantation (HPCT) is associated with a range of immunohematologic consequences including progenitor cell infusion (PCI)-related hemolysis, delayed red blood cell engraftment, and pure red cell aplasia (PRCA).	21848968
Bone necrosis	Stem Cell Exhaustion	Autologous bone marrow stem cell intralesional transplantation repairing bisphosphonate related osteonecrosis of the jaw.	21849044
Bone necrosis	Stem Cell Exhaustion	Before the injection of stem cells into the osteonecrosis, the patient underwent surgical toilet, local anesthesia was done and spongostan was applied as a carrier of stem cells suspension in the bone cavity, then 4 ml of stem cells suspension and 1 ml of patient's activated platelet-rich plasma were injected in the lesion of BRONJ.	21849044
Zygomycosis	Stem Cell Exhaustion	Mucormycosis has been reported to be occurring more frequently in hematopoietic stem cell transplant (HSCT) recipients in recent years.	21851872
Restenosis	Stem Cell Exhaustion	1-year outcome of TRIAS HR (TRI-stent adjudication study-high risk of restenosis) a multicenter, randomized trial comparing genous endothelial progenitor cell capturing stents with drug-eluting stents.	21851905
Cardiac Death, Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	This study sought to demonstrate the noninferiority of endothelial progenitor cell capturing stents (ECS) relative to drug-eluting stents (DES) regarding target lesion failure (TLF) and the composite of cardiac death, myocardial infarction, and target lesion repeat revascularization within 1 year.	21851905
Graft-vs-Host Disease, leukemia	Stem Cell Exhaustion	Minor histocompatibility antigens (mHA) mediate much of the graft vs. leukemia (GvL) effect and graft vs. host disease (GvHD) in patients who undergo allogeneic stem cell transplantation (SCT).	21858034
Heart failure	Stem Cell Exhaustion	Two of these splicing factors, RBM25 and LUC7L3, were elevated in human heart failure tissue and mediated truncation of SCN5A mRNA in both Jurkat cells and human embryonic stem cell-derived cardiomyocytes.	21859973
Neoplasms	Stem Cell Exhaustion	Immunophenotype of tumor cells with intermediate morphology suggested a progenitor cell origin for this tumor.	21860552
Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	Hematopoietic stem cell transplantation with reduced intensity conditioning from a family haploidentical donor in an infant with familial hemophagocytic lymphohistocytosis.	21863286
Familial Hemophagocytic Lymphocytosis, Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation is the only curative method for patients with familial hemophagocytic lymphohistiocytosis (FHL).	21863286
Lymphoma, Follicular	Stem Cell Exhaustion	The impact of high-dose chemotherapy, autologous stem cell transplant and conventional chemotherapy on quality of life of long-term survivors with follicular lymphoma.	21864036
Lymphoma, Follicular	Stem Cell Exhaustion	In this study we investigated the quality of life (QoL) of long-term survivors with follicular lymphoma (FL) after high-dose chemotherapy (HDCT) and autologous stem cell transplant (ASCT) using two standardized questionnaires.	21864036
diabetic	Stem Cell Exhaustion	Alterations of epithelial stem cell marker patterns in human diabetic corneas and effects of c-met gene therapy.	21866211
diabetic	Stem Cell Exhaustion	The present study examined whether limbal stem cell marker patterns were altered in diabetic corneas and whether c-met gene overexpression could normalize these patterns.	21866211
diabetic	Stem Cell Exhaustion	Cryostat sections of 28 ex vivo and 26 organ-cultured autopsy human normal and diabetic corneas were examined by immunohistochemistry using antibodies to putative limbal stem cell markers including ATP-binding cassette sub-family G member 2 (ABCG2), N-cadherin, DNp63a, tenascin-C, laminin g3 chain, keratins (K) K15, K17, K19, b(1) integrin, vimentin, frizzled 7, and fibronectin.	21866211
Diabetes	Stem Cell Exhaustion	The data suggest that limbal stem cell compartment is altered in long-term diabetes.	21866211
Graft-vs-Host Disease	Stem Cell Exhaustion	Studies of haploidentical hematopoietic stem cell transplantation (HSCT) have identified threshold doses of T cells below which severe GVHD is usually absent.	21868572
Erectile dysfunction	Stem Cell Exhaustion	Arterial erectile dysfunction: reliability of penile Doppler evaluation integrated with serum concentrations of late endothelial progenitor cells and endothelial microparticles.	21868743
Hypogonadism, Metabolic Syndrome X, Erectile dysfunction	Stem Cell Exhaustion	We recently showed the diagnostic value of a new immunophenotype of blood endothelial progenitor cells (EPC) (CD45(-)/CD34(+)/CD144(+)) and endothelial microparticles (EMP) (CD45(-)/CD144(+)/annexin V(+)) in patients with arterial erectile dysfunction (AED), particularly in patients with associated late-onset hypogonadism and/or metabolic syndrome.	21868743
Cytomegalovirus Infections	Stem Cell Exhaustion	Dynamics of cytomegalovirus (CMV) plasma DNAemia in initial and recurrent episodes of active CMV infection in the allogeneic stem cell transplantation setting: implications for designing preemptive antiviral therapy strategies.	21871245
Communicable Diseases	Stem Cell Exhaustion	Preemptive antiviral therapy strategies for active cytomegalovirus (CMV) infection occurring in allogeneic stem cell transplant recipients should be optimized to avoid overtreatment.	21871245
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	Late relapses following high-dose autologous stem cell transplantation (HD-ASCT) for Hodgkin's lymphoma (HL) in the ABVD therapeutic era.	21871246
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	Salvage chemotherapy followed by high-dose autologous stem cell transplantation (HD-ASCT) is the standard of care for patients who have relapsed or refractory Hodgkin's lymphoma (HL).	21871246
Graft-vs-Host Disease	Stem Cell Exhaustion	Significant oral graft-versus-host disease after allogeneic stem cell transplantation with the FLU/MEL conditioning regimen.	21873943
Graft-vs-Host Disease	Stem Cell Exhaustion	Oral graft-versus-host disease (GVHD) is a significant complication after allogeneic stem cell transplantation (SCT) and there is no consistent information about its characteristics in patients after reduced-intensity conditioning regimen FLU/MEL (fludarabine 120 mg/m2 and melphalan 140 mg/m2).	21873943
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Intravenous compared with oral busulfan as preparation for allogeneic hematopoietic progenitor cell transplantation for AML and MDS.	21874055
Specialty Type - cancer	Stem Cell Exhaustion	A generalized avoidant coping style before treatment increased interference from common cancer symptoms six months after hematopoietic stem cell transplantation.	21875845
Hematologic Neoplasms, Zygomycosis, Aspects of mortality statistics	Stem Cell Exhaustion	Mortality in hematologic malignancy and hematopoietic stem cell transplant patients with mucormycosis, 2001 to 2009.	21876046
Zygomycosis, Malignant Neoplasms	Stem Cell Exhaustion	We assessed clinical characteristics and mortality among stem cell transplant and hematologic malignancy patients diagnosed with mucormycosis from 2001 to 2009.	21876046
Aggressive course	Stem Cell Exhaustion	However, some cells appear to escape and generate stable colonies with an aggressive tumor stem cell-like phenotype.	21878644
Drug Eruptions	Stem Cell Exhaustion	Further studies provided evidence for the stabilization of Nrf2 due to reduced 26 S proteasome activity and increased p21 association as the driving signaling event that contributes to the transition from a high ROS quiescent state to a low ROS proliferating stage in drug-induced tumor stem cell enrichment.	21878644
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	A subset of cancer cells, termed cancer stem cells, can elude conventional treatments and eventually regenerate a tumor that is more aggressive.	21878644
Syndrome	Stem Cell Exhaustion	Cord colitis syndrome in cord-blood stem-cell transplantation.	21879899
Diarrhea	Stem Cell Exhaustion	Diarrhea is a frequent complication of hematopoietic stem-cell transplantation (HSCT).	21879899
Diarrhea	Stem Cell Exhaustion	After the transplantation and engraftment of hematopoietic stem cells from umbilical-cord blood, we observed a new syndrome of culture-negative, antibiotic-responsive diarrhea not attributable to any known cause.	21879899
Intraoperative floppy iris syndrome, Yeast infection	Stem Cell Exhaustion	Antifungal prophylaxis for allogeneic haematopoietic stem-cell transplant (alloHCT) recipients should prevent invasive mould and yeast infections (IFIs) and be well tolerated.	21880032
Virus Diseases	Stem Cell Exhaustion	Etiologies include myelotoxic agents, viral infections, and possibly transplant-related factors such as the intensity of the conditioning regimen and the source of stem cells.	21880629
Cytopenia	Stem Cell Exhaustion	Peripheral blood stem cells did not confer protection from cytopenias when compared to bone marrow.	21880629
Secondary malignant neoplasm of bone, Specialty Type - cancer, Primary malignant neoplasm	Stem Cell Exhaustion	Increased expression of putative cancer stem cell markers in primary prostate cancer is associated with progression of bone metastases.	21882211
Aggressive behavior, Prostate carcinoma	Stem Cell Exhaustion	A number of putative stem cell markers have been associated with aggressiveness of prostate cancer, including alpha 2 and alpha 6 integrin and c-met.	21882211
Prostate carcinoma, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	The study aimed to test the hypothesis that the development of bone metastasis correlates with the proportion of prostate cancer stem cell-like cells present in the primary tumor.	21882211
Prostate carcinoma	Stem Cell Exhaustion	It can be concluded that percentage of stem cell-like prostate cancer cells has a prognostic impact especially on the risk of metastatic bone progression.	21882211
Febrile Neutropenia	Stem Cell Exhaustion	We evaluated inflammatory markers in febrile neutropenic lymphoma patients undergoing high-dose chemotherapy with autologous stem cell support.	21883353
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Cytoreductive treatment with clofarabine/ara-C combined with reduced-intensity conditioning and allogeneic stem cell transplantation in patients with high-risk, relapsed, or refractory acute myeloid leukemia and advanced myelodysplastic syndrome.	21883483
Toxic effect, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Purpose of this retrospective analysis was to evaluate the antileukemic efficacy and toxicity of clofarabine-based chemotherapy followed by RIC and allogeneic stem cell transplantation (SCT) for high-risk, relapsed, or refractory acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS).	21883483
glycation	Stem Cell Exhaustion	Serum levels of advanced glycation end products (AGEs) are inversely associated with the number and migratory activity of circulating endothelial progenitor cells in apparently healthy subjects.	21884000
Cardiovascular Diseases, Cyclophosphamide/Vincristine/Dacarbazine Regimen	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) have been shown to participate in the process of vascular repair, thus playing a protective role against cardiovascular disease (CVD).	21884000
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This study evaluated azacitidine as treatment of minimal residual disease (MRD) determined by a sensitive donor chimerism analysis of CD34(+) blood cells to pre-empt relapse in patients with CD34(+) myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (HSCT).	21886171
Thalassemia	Stem Cell Exhaustion	Stem-cell transplantation is the preferred treatment for the severe forms of thalassemia.	21886666
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Sclerodermatous chronic graft-versus-host disease (cGVHD) following allogeneic hematopoietic stem cell transplantation (HSCT) in children is difficult to treat and life-threatening.	21890415
Specialty Type - cancer	Stem Cell Exhaustion	Zinc finger E-box-binding (ZEB) proteins ZEB1 and ZEB2 are transcription factors essential in TGF-b-mediated senescence, epithelial-to-mesenchymal transition (EMT), and cancer stem cell functions.	21890822
Liver carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Prediction of posthepatectomy recurrence of hepatocellular carcinoma by circulating cancer stem cells: a prospective study.	21892074
Liver carcinoma, Specialty Type - cancer, Hollings Cancer Center	Stem Cell Exhaustion	To investigate whether circulating cancer stem cells (CSCs) of hepatocellular carcinoma (HCC) can predict its recurrence after hepatectomy.	21892074
Multiple Myeloma	Stem Cell Exhaustion	[Optimization of mobilization regimes of blood hemopoietic stem cells in patients with multiple myeloma].	21894752
Trauma, Nervous System	Stem Cell Exhaustion	Interest in promoting regeneration of the injured nervous system has recently turned toward the use of endogenous stem cells.	21895532
Traumatic	Stem Cell Exhaustion	Endogenous GFAP-positive neural stem/progenitor cells in the postnatal mouse cortex are activated following traumatic brain injury.	21895532
Graft-vs-Host Disease	Stem Cell Exhaustion	Methotrexate dose delivery is more important than ciclosporin level in graft-versus-host disease prophylaxis following T-replete reduced-intensity sibling allogeneic stem cell transplant.	21898174
Chronic graft-versus-host disease	Stem Cell Exhaustion	We investigated the contributions of methotrexate (MTX) and ciclosporin (CsA) prophylaxis to acute/chronic graft-versus-host disease (a/cGvHD) prevention following reduced-intensity conditioned allogeneic haematopoietic stem cell transplant (HSCT).	21898174
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Emerging evidence suggests that tumors contain and are driven by a cellular component that displays stem cell properties, the so-called cancer stem cells (CSCs).	21898409
Specialty Type - cancer, Primary Neoplasm	Stem Cell Exhaustion	CD133 and CD44 cell surface markers do not identify cancer stem cells in primary human gastric tumors.	21898409
Prostatic Neoplasms	Stem Cell Exhaustion	The location of stem cells in the epithelium of the prostatic acinus remains uncertain, as does the cellular origin of prostatic neoplasia.	21898875
Disease, Neurodegenerative Disorders	Stem Cell Exhaustion	Induced pluripotent stem cell (iPSC) technology can be used to model human disorders and provide novel opportunities to study cellular mechanisms and establish therapeutic strategies against various diseases, including neurodegenerative diseases.	21900357
Alzheimers Disease	Stem Cell Exhaustion	Modeling familial Alzheimer's disease with induced pluripotent stem cells.	21900357
Liver Failure	Stem Cell Exhaustion	This study demonstrated the safety and short-term efficacy of autologous bone marrow-derived mesenchymal stem cell injection in liver cell failure.	21900788
Uveal melanoma	Stem Cell Exhaustion	Expression of CD133 and other putative stem cell markers in uveal melanoma.	21900792
Cutaneous Melanoma, Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	'Cancer stem cells' (CSCs) are tumor cells with stem cell properties hypothesized to be responsible for tumorigenesis, metastatis, and resistance to treatment, and have been identified in different tumors including cutaneous melanoma, using stem cell markers such as CD133.	21900792
Uveal melanoma	Stem Cell Exhaustion	This study explored expression of CD133 and other putative stem cell markers in uveal melanoma.	21900792
Uveal melanoma	Stem Cell Exhaustion	Eight uveal melanoma cell lines were subjected to flow-cytometric (fluorescence-activated cell sorting) analysis of CD133 and other stem cell markers.	21900792
Uveal melanoma	Stem Cell Exhaustion	Ocular, uveal melanoma, and hematopoietic stem cell distributions of C-terminal and N-terminal CD133 mRNA splice variants were compared by reverse-transcription PCR.	21900792
Uveal melanoma	Stem Cell Exhaustion	Further experiments are needed to isolate stem cell marker-positive cells, to evaluate their functional properties and to explore therapeutical approaches to these putative CSCs in uveal melanoma.	21900792
Fibromatosis	Stem Cell Exhaustion	Recapitulation of fibromatosis nodule by multipotential stem cells in immunodeficient mice.	21901157
Fibromatosis	Stem Cell Exhaustion	In this study, we demonstrate that fibromatosis stem cells (FSCs) can be isolated from palmar nodules but not from cord or normal palm tissues.	21901157
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Although BCR-ABL+ stem cells in chronic myeloid leukemia (CML) resist elimination by targeted pharmacotherapy in most patients, immunological graft-versus-leukemia effects can cure the disease.	21904381
Lupus Erythematosus, Systemic, physiopathological	Stem Cell Exhaustion	Reversal of serologic, immunologic, and histologic dysfunction in mice with systemic lupus erythematosus by long-term serial adipose tissue-derived mesenchymal stem cell transplantation.	21904997
Lupus Erythematosus, Encephalitis, St. Louis	Stem Cell Exhaustion	To investigate the efficacy of human adipose tissue-derived mesenchymal stem cell (AD-MSC) transplantation in systemic lupus erythematosus (SLE) and to determine the optimal transplantation window for stem cells either before or after disease onset.	21904997
Multiple Myeloma	Stem Cell Exhaustion	Effects of peripheral blood stem cell apheresis on systemic cytokine levels in patients with multiple myeloma.	21905955
Multiple Myeloma	Stem Cell Exhaustion	We investigated how peripheral blood stem cell (PBSC) collection affected plasma angioregulatory cytokine levels in 15 consecutive myeloma patients.	21905955
Hypertension, CTCAE	Stem Cell Exhaustion	Effects of calcium channel blockers on glucose tolerance, inflammatory state, and circulating progenitor cells in non-diabetic patients with essential hypertension: a comparative study between azelnidipine and amlodipine on glucose tolerance and endothelial function--a crossover trial (AGENT).	21906391
Hypertension, CTCAE	Stem Cell Exhaustion	These results suggest that azelnidipine treatment may have beneficial effects on glucose tolerance, insulin sensitivity, the inflammatory state, and number of circulating progenitor cells in non-diabetic patients with essential hypertension.	21906391
Neoplasms	Stem Cell Exhaustion	Recent findings on the regulation of stem cell (SC) division and reprogramming suggest the intriguing possibility that p53 also carries out its tumor suppression function by regulating SC homeostasis.	21907001
Pulmonary Complication	Stem Cell Exhaustion	Lethal pulmonary complications after pediatric allogeneic hematopoietic stem cell transplantation.	21909046
Pulmonary Complication	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) in children is accompanied by a transplant-related mortality of 10% to 30%, which is the result of lethal pulmonary complications (LPCs) in many cases.	21909046
Chronic Kidney Disease, CTCAE	Stem Cell Exhaustion	Endostatin and vascular endothelial growth factor: potential regulators of endothelial progenitor cell number in chronic kidney disease.	21909059
Specialty Type - cancer	Stem Cell Exhaustion	Stem cells and cancer cells accumulate MB(d)s by evading autophagosome encapsulation and exhibit low autophagic activity.	21909099
Specialty Type - cancer	Stem Cell Exhaustion	MB(d) enrichment enhances reprogramming to induced pluripotent stem cells and increases the in vitro tumorigenicity of cancer cells.	21909099
Post-Treatment Lyme Disease Syndrome, Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Posttransplant lymphoproliferative disorders (PTLDs) are among the most serious and potentially fatal complications of both stem-cell and solid-organ transplantation.	21911168
Cessation of life, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In this high risk AML population, HiDAC/MITO induction demonstrated an overall response rate of 55% with a low induction death rate of 9% and allowed 32 (41%) patients to proceed to allogeneic stem cell transplant.	21913806
Multiple Myeloma	Stem Cell Exhaustion	An overview of the VISTA trial: newly diagnosed, untreated patients with multiple myeloma ineligible for stem cell transplantation.	21913826
Multiple Myeloma	Stem Cell Exhaustion	The VISTA study evaluated the effect of this combination with or without the first-in-class proteasome inhibitor bortezomib in newly diagnosed myeloma patients who were not candidates for autologous stem cell transplantation.	21913826
melphalan/prednisone protocol, Multiple Myeloma	Stem Cell Exhaustion	These results confirm the superiority of MP plus bortezomib combination over MP therapy in treatment-naive patients with newly diagnosed multiple myeloma who are ineligible for autologous stem cell transplantation.	21913826
Syringocystadenoma Papilliferum	Stem Cell Exhaustion	We focused on one cell type, undifferentiated clear cells, which have been suggested to be pluripotent cells bearing stem cell nature in syringocystadenoma papilliferum.	21914158
Neoplasms	Stem Cell Exhaustion	Immunohistochemically, the tumor cells were negative for cytokeratin 15, which is known as a relatively specific marker for multipotent stem cells in the follicular bulge.	21914158
Specialty Type - cancer, Glioblastoma	Stem Cell Exhaustion	Identification of cancer stem cells from human glioblastomas: growth and differentiation capabilities and CD133/prominin-1 expression.	21916848
Specialty Type - cancer, Glioblastoma	Stem Cell Exhaustion	CD133 can be a marker of tumorigenic CSCs (cancer stem cells) in human GBM (glioblastoma multiforme), although tumorigenic CD133-negative CSCs have been also isolated.	21916848
Common (qualifier value), Malignant tumor of colon	Stem Cell Exhaustion	Common cancer stem cell gene variants predict colon cancer recurrence.	21918173
Malignant tumor of colon, Specialty Type - cancer	Stem Cell Exhaustion	Recent evidence suggests that cancer stem cells (CSC) are responsible for key elements of colon cancer progression and recurrence.	21918173
MS gene	Stem Cell Exhaustion	To assess safety and tolerability of treatment with autologic multipotent mesenchymal stem cells (MSC) in multiple sclerosis (MS), we have obtained autologic red bone marrow-derived MSC from 8 patients.	21919233
Multiple Myeloma	Stem Cell Exhaustion	Non-cryopreserved hematopoietic stem cell transplantation in multiple myeloma, a single center experience.	21919958
Multiple Myeloma	Stem Cell Exhaustion	Several clinical trials have shown the superiority of high-dose therapy (HDT) and autologous stem cell transplantation (ASCT) over conventional dose therapy for patients with multiple myeloma.	21919958
Hepatitis B	Stem Cell Exhaustion	New therapeutic options like monoclonal antibodies (anti-CD20/rituximab) and hematopoietic stem cell transplantation (HSCT) have increased both the effectiveness of therapies and the risk for reactivation of Hepatitis B virus (HBV).	21920838
Pancreatic Ductal Adenocarcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Comparative evaluation of cancer stem cell markers in normal pancreas and pancreatic ductal adenocarcinoma.	21922151
Pancreatic Ductal Adenocarcinoma, Specialty Type - cancer, Neoplasms, Resistance Process, ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Stem Cell Exhaustion	Chemoresistance and self-renewal of cancer stem cells (CSC), found in many tumors including pancreatic ductal adenocarcinoma (PDAC), are believed to underlie tumor mass regrowth.	21922151
Multiple Myeloma	Stem Cell Exhaustion	Comparison of fixed dose pegfilgrastim and daily filgrastim after autologous stem cell transplantation in patients with multiple myeloma autografted on a outpatient basis.	21922508
Chemotherapy-Induced Febrile Neutropenia	Stem Cell Exhaustion	Peg-filgrastim (PEG), a long-acting recombinant G-CSF, has similar efficacy when compared to conventional G-CSF for chemotherapy-induced neutropenia, but little is known about its use in the autologous stem-cell transplantation (ASCT) setting, namely in patients programmed to be autografted on outpatient basis.	21922508
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Multiple extramedullary relapses without bone marrow involvement after second allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia.	21923886
Acute leukemia	Stem Cell Exhaustion	Our experience demonstrates that infusing a megadose of extensively T-cell-depleted hematopoietic peripheral blood stem cells after an immuno-myeloablative conditioning regimen in acute leukemia patients ensures sustained engraftment with minimal GvHD without the need of any post-transplant immunosuppressive treatment.	21925085
Hematologic Neoplasms	Stem Cell Exhaustion	Hematopoietic stem cell transplantation provides the only potential curative option in many patients with hematological malignancies.	21925089
Hematologic Neoplasms	Stem Cell Exhaustion	Nonmyeloablative haploidentical stem cell transplantation with post-transplantation cyclophosphamide seems to be a promising, potentially curative, option for patients with hematological malignancies who either lack an HLA-matched related or unrelated donor, or in whom a myeloablative preparative regimen is contraindicated due to significant co-morbidities or history of extensive pre-treatment.	21925089
leukemia	Stem Cell Exhaustion	Allogeneic stem cell transplantation for patients harboring T315I BCR-ABL mutated leukemias.	21926354
Graft-vs-Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic graft-versus-host disease (GVHD) remains a serious complication after allogeneic hematopoietic stem cell transplantation (HCT).	21926960
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	Endothelial progenitor cells are associated with response to chemotherapy in human non-small-cell lung cancer.	21927909
Neoplasms	Stem Cell Exhaustion	Bone marrow-derived endothelial progenitor cells (EPCs) play an important role in angiogenesis and tumor growth.	21927909
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	High-dose thiotepa, etoposide and carboplatin as conditioning regimen for autologous stem cell transplantation in patients with high-risk non-Hodgkin lymphoma.	21928053
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	High-dose chemotherapy conditioning regimens followed by autologous stem cell transplantation generally provide good results in non-Hodgkin lymphoma.	21928053
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	The thiotepa, etoposide and carboplatin conditioning regimen for autologous stem cell transplantation in non-Hodgkin lymphoma has a good anti-lymphoma effect and provides encouraging results in terms of response to treatment and 5-year overall survival.	21928053
Specialty Type - cancer	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) is an intensive cancer therapy entailing numerous physical, emotional, cognitive, and practical challenges.	21928059
Prostate carcinoma, Specialty Type - cancer, Hormone refractory prostate cancer	Stem Cell Exhaustion	A stem cell model of prostate cancer tumourigenesis explains progression to castration resistant prostate cancer (CRPC) and offers novel perspectives in targeting this cancer in its more advanced forms.	21929909
Neoplasms	Stem Cell Exhaustion	Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14.	21930782
Neoplasms	Stem Cell Exhaustion	Overall, these studies identify GATA-3 as an important regulator of tumor initiation through its ability to promote the differentiation of committed luminal progenitor cells.	21930782
Colorectal Carcinoma	Stem Cell Exhaustion	Circulation of progenitor cells in obese and lean colorectal cancer patients.	21930958
Cytogenetic Complete Response	Stem Cell Exhaustion	The purpose of this study was to measure the frequency of circulating CD34-positive endothelial and progenitor cells in the circulation and evaluate their potential values as CRC biomarkers.	21930958
Hematological Disease, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Myelodysplastic syndromes (MDSs) are clonal disorders of hematopoietic stem cells (HSCs) characterized by ineffective hematopoiesis.	21933023
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukemias arise from a rare population of leukemic cells, known as leukemic stem cells, which initiate the disease and contribute to frequent relapses.	21933861
Tumor necrosis	Stem Cell Exhaustion	This study examined the effects of cytokines interleukin-1b, tumor necrosis factor-a and interferon-g on apoptosis of b-thal/HbE erythroid progenitor cells in vitro, including nitric oxide-mediated apoptotic processes.	21934298
Thalassemia	Stem Cell Exhaustion	The marked sensitivity of erythroid progenitor cells from b-thal/HbE patients to cytokine-induced apoptosis via an NO-mediated process reflects a proapoptotic status of such thalassemic red blood cells.	21934298
Fatty Liver Disease	Stem Cell Exhaustion	Ultrastructural examinations of the liver progenitor/oval cells in children with NASH show a quite prominent number of these cells, especially their two types, hepatic progenitor cells (HPCs) and intermediate hepatocyte-like cells (IHCs), with intermediate bile-like cells being the least frequent.	21940261
Adenomatous Polyposis Coli, Peutz-Jeghers Syndrome	Stem Cell Exhaustion	Aberrant intestinal stem cell lineage dynamics in Peutz-Jeghers syndrome and familial adenomatous polyposis consistent with protracted clonal evolution in the crypt.	21940722
Burn injury	Stem Cell Exhaustion	Their resemblance to ASCs could also be cause for speculation that in deep burns the subcutaneous adipose tissue might be an important stem cell source for the healing wound.	21944933
Burn, CTCAE	Stem Cell Exhaustion	A population of multipotent stem cells in burn eschar could be an interesting resource for tissue engineering approaches to heal burn wounds.	21944933
Burn, CTCAE, Burn injury	Stem Cell Exhaustion	The origin of the cells from burn eschar remains unclear, but it is likely they represent a population of adult stem cells mobilized from other parts of the body in response to the burn injury.	21944933
Huntingtons Disease Pathway	Stem Cell Exhaustion	No change in progenitor cell proliferation in the hippocampus in Huntington's disease.	21946006
Neutropenia, Hematologic Neoplasms, Pregnancy Complications, Infectious	Stem Cell Exhaustion	18F-FDG PET/CT for diagnosing infectious complications in patients with severe neutropenia after intensive chemotherapy for haematological malignancy or stem cell transplantation.	21947022
Neutropenia, Hematologic Neoplasms	Stem Cell Exhaustion	Twenty-eight consecutive patients with neutropenia as a result of intensive chemotherapy for haematological malignancies or myeloablative therapy for haematopoietic stem cell transplantation were prospectively included.	21947022
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	To evaluate the prognostic value of the cell of origin (COO) in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBLC), prospectively treated by rituximab, dexamethasone, high-dose cytarabine, and cisplatin (R-DHAP) versus rituximab, ifosfamide, carboplatin, and etoposide and followed by intensive therapy plus autologous stem-cell transplantation on the Collaborative Trial in Relapsed Aggressive Lymphoma (CORAL) trial.	21947824
Adult Glioblastoma	Stem Cell Exhaustion	Mast cell accumulation in glioblastoma with a potential role for stem cell factor and chemokine CXCL12.	21949886
Inflammation, Psoriasis vulgaris	Stem Cell Exhaustion	In the skin, vitamin D receptor (VDR) is a master regulator of epidermal barrier function, inflammation, stem cell proliferation and microbial defense; therefore, we tested whether VDR 3'-regulatory haplotypes, a portion of which affect VDR transcriptional efficiency, allelic symmetry and mRNA turnover, were associated with psoriasis vulgaris.	21951018
Ischemic, Vascular System Injuries	Stem Cell Exhaustion	Platelet stromal-cell-derived factor-1 (SDF-1) plays a pivotal role in angiogenesis and the regeneration of ischaemic tissue through the regulation of haematopoietic progenitor cells and is upregulated at the sites of vascular injury and platelet activation.	21951424
Ischemia	Stem Cell Exhaustion	Autologous bone marrow-derived stem cells have been ascribed an important therapeutic role in No-Option Critical limb Ischemia (NO-CLI).	21951607
Carcinoma, Neoplastic Stem Cells	Stem Cell Exhaustion	Mixed adenoneuroendocrine carcinoma (MANEC) of the gallbladder: a possible stem cell tumor?	21951672
Neoplasms, Genotype	Stem Cell Exhaustion	The aforementioned histological, ultrastructural and immunohistochemical profile is strongly suggestive of a biphenotypic stem/progenitor cell tumor of the gallbladder.	21951672
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukemia of donor origin after allogeneic stem cell transplantation from a sibling who harbors germline XPD and XRCC3 homozygous polymorphisms.	21951951
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Additionally, polymorphisms of the XPA, XPD, XRCC1, XRCC3 and RAD51 DNA repair genes revealed three unfavorable alleles with low DNA repair capacity.In summary, we report the first case of AML involving XPD and XRCC3 polymorphisms from donor origin following allogeneic stem cell transplantation and highlight the potential need for careful analysis of DNA repair gene polymorphisms in selecting candidate donors prior to allogeneic stem cell transplantation.	21951951
Degenerative polyarthritis	Stem Cell Exhaustion	Generation of human induced pluripotent stem cells from osteoarthritis patient-derived synovial cells.	21953087
Degenerative polyarthritis	Stem Cell Exhaustion	This study was undertaken to generate and characterize human induced pluripotent stem cells (PSCs) from patients with osteoarthritis (OA) and to examine whether these cells can be developed into disease-relevant cell types for use in disease modeling and drug discovery.	21953087
leukemia, MLL/MLLT1 Fusion Gene	Stem Cell Exhaustion	The observed inconsistency between the clinical cure and the presence of detectable MLL/ENL transcript suggests the existence of a MLL/ENL-expressing "preleukemia" stem cells, similar to what demonstrated for the AML1/ETO-positive leukemia setting.	21953510
Respiratory Tract Infections	Stem Cell Exhaustion	Influenza viruses cause potentially fatal respiratory infections in stem cell transplant patients.	21954837
Cessation of life	Stem Cell Exhaustion	We propose that reconstructing host immunity through adoptive transfer of influenza virus-specific T cells will reduce the frequency of influenza-related deaths in the period of severe immune suppression that follows stem cell transplantation.	21954837
Amyotrophic Lateral Sclerosis, Antilymphocyte Serum	Stem Cell Exhaustion	Mesenchymal stem cells/marrow stromal cells (MSC) represent a promising tool for stem cell-based clinical trials in amyotrophic lateral sclerosis (ALS).	21954839
Subcutaneous panniculitis-like T-cell lymphoma	Stem Cell Exhaustion	Durable remission in a patient with refractory subcutaneous panniculitis-like T-cell lymphoma relapse after allogeneic hematopoietic stem cell transplantation through withdrawal of cyclosporine.	21959522
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation is an important part of therapy in patients with multiple myeloma.	21959988
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Prognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks.	21960591
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Genes targeted by Polycomb group (PcG) proteins and genes associated with bivalent histone marks in stem cells showed increased aberrant methylation in AML (P < .0001).	21960591
Multiple Myeloma	Stem Cell Exhaustion	Autologous haemopoietic stem-cell transplantation followed by allogeneic or autologous haemopoietic stem-cell transplantation in patients with multiple myeloma (BMT CTN 0102): a phase 3 biological assignment trial.	21962393
Multiple Myeloma	Stem Cell Exhaustion	Autologous haemopoietic stem-cell transplantation (HSCT) improves survival in patients with multiple myeloma, but disease progression remains an issue.	21962393
Electrocardiogram: myocardial infarction (finding), Coronary heart disease	Stem Cell Exhaustion	[Coronary disease extension determines mobilization of endothelial progenitor cells and cytokines after a first myocardial infarction with ST elevation].	21962766
Coronary heart disease	Stem Cell Exhaustion	The aim of this study was to determine the time sequence of various sets of endothelial progenitor cells and angiogenic cytokines (vascular endothelial growth factor, hepatocyte growth factor) according to the degree of extension of the postinfarction coronary disease.	21962766
One Vessel Coronary Disease, Acute myocardial infarction	Stem Cell Exhaustion	Although the release kinetics of different subsets of endothelial progenitor cells in patients with a first acute myocardial infarction with ST elevation was similar in those with single vessel disease to those with multivessel disease, the number of circulating endothelial progenitor cells was greater in the patients with single vessel disease.	21962766
Secondary Acute Myeloid Leukemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Upfront allogeneic blood stem cell transplantation for patients with high-risk myelodysplastic syndrome or secondary acute myeloid leukemia using a FLAMSA-based high-dose sequential conditioning regimen.	21963618
PAFAH1B1 wt Allele	Stem Cell Exhaustion	The purpose of our prospective single-center study was to examine the safety and efficacy of an allogeneic hematopoietic stem cell transplantation (HSCT) following a sequential conditioning regimen as first-line therapy for previously untreated patients with high-risk MDS or sAML.	21963618
Acute lymphocytic leukemia, Myeloid Leukemia, Chronic, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We evaluated the ability of an MM ranking system, HistoCheck, to predict the risk associated with HLA class I disparity in a population of 744 single allele or antigen HLA-A, -B, or -C MM myeloablative unrelated donor hematopoietic stem cell transplantation recipients with acute myelogenous leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia, or myelodysplastic syndrome, facilitated through the National Marrow Donor Program between 1988 and 2003.	21963622
Infection	Stem Cell Exhaustion	Diagnostic value of serum procalcitonin and C-reactive protein for infections after allogeneic hematopoietic stem cell transplantation versus nontransplant setting.	21963733
Graft-vs-Host Disease	Stem Cell Exhaustion	The purpose of this study was to evaluate its diagnostic value after hematopoietic stem cell transplantation (HSCT), where non-infectious febrile complications such as graft-versus-host disease frequently develop.	21963733
Septicemia, Necrosis, Disseminated Intravascular Coagulation	Stem Cell Exhaustion	On day 5 after stem cell transplantation, progressive local tissue necrosis led to septicemia and disseminated intravascular coagulation.	21963743
Ischemia	Stem Cell Exhaustion	Vasoprotective effects of erythropoietin in animal models are mediated by endothelium-derived NO and/or mobilization of EPCs (endothelial progenitor cells) and may be enhanced by ischaemia: whether they are present in humans is unknown.	21966999
PAFAH1B1 wt Allele, Erythropoietin	Stem Cell Exhaustion	Notch signaling has been linked to impaired erythropoietic and megakaryopoietic development of CD34+ progenitor cells, but its role in MDS is unclear.	21967505
Neoplasms	Stem Cell Exhaustion	The immunohistochemical expression of the putative brain tumor stem cell markers CD133 and Nestin in paraffin sections was analyzed using morphometry.	21971709
Post-Traumatic Stress Disorder	Stem Cell Exhaustion	Posttraumatic growth, social support, and social constraint in hematopoietic stem cell transplant survivors.	21972000
Neurodegenerative Disorders, Minor Axis Cross-sectional Diameter, Motor Neuron Disease	Stem Cell Exhaustion	The lack of effective drug therapies for motor neuron diseases (MND), and in general for all the neurodegenerative disorders, has increased the interest toward the potential use of stem cells.	21978082
Cancer Pain, Non-Metastatic Childhood Soft Tissue Sarcoma	Stem Cell Exhaustion	A novel splice variant of the stem cell marker LGR5/GPR49 is correlated with the risk of tumor-related death in soft-tissue sarcoma patients.	21978106
Pneumonia, Interstitial	Stem Cell Exhaustion	Interstitial pneumonia after autologous hematopoietic stem cell transplantation in B-cell non-hodgkin lymphoma.	21978956
Teratoma	Stem Cell Exhaustion	Our results suggest that the origin of this uterine teratoma is most likely pluripotential stem cell of uterus or primordial germ cell before meiosis I.	21979590
Kidney Failure, Acute	Stem Cell Exhaustion	Several combined immunosuppression therapies failed to resolve recurrent acute renal failure; autologous peripheral blood stem cell transplantation was therefore applied.	21979795
Neoplasms	Stem Cell Exhaustion	This offers an improved understanding of the pathways involved in tumor growth from engrafted pluripotent stem cells, which could facilitate the use of ES and iPS cells in regenerative medicine.	21981310
Alopecia, senile	Stem Cell Exhaustion	Involvement of the bulge region with decreased expression of hair follicle stem cell markers in senile female cases of alopecia areata.	21981340
anatomical bulb, senile	Stem Cell Exhaustion	To investigate expression levels of stem cell markers, especially CD200, in two senile female cases of AA with unusual lymphocytic cell infiltrates surrounding both the bulge and the bulbar regions.	21981340
Malignant tumor of colon, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Human colon cancer harbors a small subfraction of tumor-initiating cells (TICs) that is assumed to be a functionally homogeneous stem-cell-like population driving tumor maintenance and metastasis formation.	21982235
Renal Cell Carcinoma	Stem Cell Exhaustion	Comprehensive analysis of clinical significance of stem-cell related factors in renal cell cancer.	21982273
Refractory Cytopenia of Childhood	Stem Cell Exhaustion	The present analysis strongly suggests that altered expression of several stem cell related factors may play different roles in RCC.	21982273
Delayed onset, Decreased platelet count	Stem Cell Exhaustion	PR-104 given weekly may be a suitable protocol for further clinical evaluation as a short course of treatment with fractionated radiotherapy or haematopoietic stem cell support, as its duration of dosing is restricted by delayed-onset and protracted thrombocytopenia.	21982454
Lung diseases	Stem Cell Exhaustion	The goal of studying early disease in multiple cell and tissue types has driven interest in the use of induced pluripotent stem cells (iPSCs) to model lung disease.	21984571
Gastrointestinal mucositis	Stem Cell Exhaustion	Mucositis after reduced intensity conditioning and allogeneic stem cell transplantation.	21985850
Nephrotic Syndrome	Stem Cell Exhaustion	Early occurrence of nephrotic syndrome associated with cord blood stem cell transplantation.	21986678
Graft-vs-Host Disease, Nephrotic Syndrome, Nuclear non-senile cataract, Chronic graft-versus-host disease	Stem Cell Exhaustion	Nephrotic syndrome (NS) associated with hematopoietic stem cell transplantation (HSCT) is usually related to chronic graft-versus-host disease (GVHD) and invariably occurs later than 100 days after transplantation.	21986678
Cerebral Small Vessel Diseases, Dementia, Vascular	Stem Cell Exhaustion	We assayed autopsy tissue from 13 vascular dementia patients with small vessel disease and 12 age-matched subjects without cerebrovascular pathology, undertaking immunohistochemistry in the affected brain area and the subventricular zone with a well-characterized battery of antibodies to detect neural stem cells/progenitors and immature neurones, as well as choline acetyltransferase immunoreactivity.	21988073
Cerebrovascular accident	Stem Cell Exhaustion	Recent work has highlighted a significant increase of neural stem/progenitor cells after stroke in humans.	21988073
Cerebrovascular Disorders, Cerebral Small Vessel Diseases	Stem Cell Exhaustion	We showed significant increases ranging from 33% to 92% (P < 0.05) in neural progenitor cells around the areas of microvascular pathology and in the subventricular zone in patients with small vessel disease compared to individuals without cerebrovascular changes, even in patients with severe cerebrovascular disease, as defined by neuropathological assessment.	21988073
Gastrointestinal mucositis	Stem Cell Exhaustion	* It is anticipated that there is a difference in pharmacokinetics in patients after kidney or liver transplantation compared with patients undergoing stem cell transplantation, because of mucositis and interacting drugs (e.g.	21988410
Allogeneic Hematopoietic Stem Cell Transplantation	Stem Cell Exhaustion	AIM To develop a population pharmacokinetic model of ciclosporin (CsA) in haematopoietic allogeneic stem cell transplantation to facilitate a limited sampling strategy to determine systemic exposure (area under the curve [AUC]), in order to optimize CsA therapy in this patient population.	21988410
Neoplasms	Stem Cell Exhaustion	Sox-2 was the most prevalent stem cell marker in PA, and many tumors showed synaptophysin positivity.	21989351
Osteoarthritis of hip	Stem Cell Exhaustion	To determine whether the marrow conversion index (MCI) in MRI is related to the total number of mononuclear and mesenchymal stem cells (MSCs) in proximal femoral metaphysis of patients with hip osteoarthritis.	21990160
Malignant neoplasm of stomach	Stem Cell Exhaustion	Polycomb repressive complex (PRC) target genes in embryonic stem cells were significantly enriched among EBV(-)/high-methylation genes and commonly methylated gastric cancer genes (P = 2 x 10(-15) and 2 x 10(-34), respectively), but not among EBV(+) tumor-specific methylation genes (P = 0.2), suggesting a different cause for EBV(+)-associated de novo methylation.	21990320
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Plerixafor and Filgrastim XM02 (Tevagastrim) as a first line peripheral blood stem cell mobilisation strategy in patients with multiple myeloma and lymphoma candidated to autologous bone marrow transplantation.	21992403
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	CD33 is a well-known stem cell target in acute myeloid leukemia.	21993666
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	CD33 is expressed abundantly on immature CD34(+)/CD38(-) stem cells and may serve as a stem cell target in chronic myeloid leukemia.	21993666
gemtuzumab ozogamicin, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	CD34(+)/CD38(-) stem cells in chronic myeloid leukemia express Siglec-3 (CD33) and are responsive to the CD33-targeting drug gemtuzumab/ozogamicin.	21993666
Chronic leukemia (category)	Stem Cell Exhaustion	So far, however, little is known about expression of CD33 on leukemic stem cells in chronic leukemias.	21993666
Myeloid Leukemia, Chronic, Myeloid neoplasm	Stem Cell Exhaustion	Chronic myelogenous leukemia (CML) is a neoplasm of myeloid progenitor cells expressing Bcr-Abl fusion protein.	21993902
Leukemia, Myelocytic, Acute, Lymphoproliferative Disorders	Stem Cell Exhaustion	We evaluated applying less restrictive radiological criteria, when supported by specific microbiological findings, to define IPA in acute myeloid leukaemia (AML), lymphoproliferative diseases (LD) and allogeneic stem cell transplant (allo-SCT) patients.	21999366
Lymphedema	Stem Cell Exhaustion	Autologous stem cells for the treatment of post-mastectomy lymphedema: a pilot study.	21999374
Lymphedema	Stem Cell Exhaustion	Our objective was to determine the efficacy of autologous stem cells (ASC) in the treatment of lymphedema secondary to mastectomy and axillary lymphadenectomy in comparison with traditional decongestive treatment with compression sleeves.	21999374
B-Cell Lymphomas	Stem Cell Exhaustion	High-dose therapy and autologous stem cell transplantation in first relapse for diffuse large B cell lymphoma in the rituximab era: an analysis based on data from the European Blood and Marrow Transplantation Registry.	22005647
B-Cell Lymphomas	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) consolidation remains the treatment of choice for patients with relapsed diffuse large B cell lymphoma.	22005647
Hematologic Neoplasms	Stem Cell Exhaustion	Patients with hematologic malignancies were conditioned using a rabbit antithymocyte globulin-based reduced-intensity conditioning regimen for allogeneic stem cell transplantation.	22005648
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic graft-versus-host disease (cGVHD) remains a major cause of non-relapse morbidity and mortality after allogeneic hematopoietic stem cell transplantation.	22005783
MYELODYSPLASTIC SYNDROME, Acute leukemia	Stem Cell Exhaustion	We assessed HLA-mismatched locus-specific comparison of the outcomes of 351 single-unit UCB and 1,028 unrelated bone marrow (UBM) adult recipients 16 years old or older at the time of transplantation who received first stem cell transplantation with myeloablative conditioning for acute leukemia or myelodysplastic syndromes.	22008851
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Early versus delayed autologous stem cell transplantation (SCT) results in comparable overall survival in patients with multiple myeloma (MM) who receive alkylator-based therapies.	22009602
Specialty Type - cancer, Leukoplakia	Stem Cell Exhaustion	Two stem cell markers, ATP-binding cassette, G2 subfamily (ABCG2) and BMI-1, predict the transformation of oral leukoplakia to cancer: a long-term follow-up study.	22009787
Head and Neck Neoplasms	Stem Cell Exhaustion	ATP-binding cassette, G2 subfamily (ABCG2) and BMI-1 are stem cell markers that have been found to be associated with head and neck tumorigenesis.	22009787
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	The aim of this study was to evaluate immunohistochemical approaches for predicting the survival of patients with DLBCL following autologous hematopoietic stem cell transplantation (AHSCT).	22009820
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	Acute lymphoblastic leukemia (ALL) in second complete remission is one of the most common indications for allogeneic hematopoietic stem cell transplantation (HSCT) in pediatric patients.	22010101
Infectious Lung Disorder	Stem Cell Exhaustion	A concomitant pulmonary infection was identified more frequently among non-AL patients (P = .005 vs allogeneic hematopoietic stem cell transplant and P = .048 vs others).	22010103
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer patients were treated twice with autologous CD34+ hematopoietic stem cell-derived, GM-CSF/IFN-g-differentiated DCs pulsed with autologous tumor lysate and KLH, by 4-week interval.	22013914
Glioma	Stem Cell Exhaustion	Expression profile of embryonic stem cell-associated genes Oct4, Sox2 and Nanog in human gliomas.	22014056
Glioma, Specialty Type - cancer, Carcinogenesis	Stem Cell Exhaustion	To investigate whether Oct4, Sox2 and Nanog, three core regulatory factors maintaining pluripotency and self-renewal of embryonic stem cells (ESCs), are coexpressed in human gliomas, and whether their expression might be linked to carcinogenesis and the formation of cancer stem cells (CSCs).	22014056
Childhood Breast Carcinoma	Stem Cell Exhaustion	Aldehyde dehydrogenase 1 (ALDH1) has been identified as a reliable marker of breast cancer stem cells, and its clinical significance as a prognostic indicator of breast cancer has been reported by several investigators.	22014057
Intimal proliferation	Stem Cell Exhaustion	These results indicate that monocyte-derived progenitor cells are associated with cardiac allograft vasculopathy, have the ability to transdifferentiate into smooth muscle cells, and thus may contribute to intimal hyperplasia of coronary arteries in cardiac allograft vasculopathy.	22014346
Autoimmune Diseases	Stem Cell Exhaustion	Stem cell treatment for patients with autoimmune disease by systemic infusion of culture-expanded autologous adipose tissue derived mesenchymal stem cells.	22017805
Dermatitis, Atopic, Polymyositis, Rheumatoid Arthritis, MS gene, Autoimmune reaction	Stem Cell Exhaustion	Here we report the outcome of treatments with culture expanded human adipose-derived mesenchymal stem cells (hAdMSCs) of 10 patients with autoimmune associated tissue damage and exhausted therapeutic options, including autoimmune hearing loss, multiple sclerosis, polymyotitis, atopic dermatitis and rheumatoid arthritis.	22017805
Endothelium	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) play an important role in repairing endothelial injury.	22018014
Encephalitis	Stem Cell Exhaustion	Altogether in 15/32 (47%) of the cases the clinician had a strong suspicion of cause other than EBV for the patients' CNS symptoms/findings.Of note, 7 of 11 (64%) patients with stem cell transplantation had encephalitis (univariate odds ratio 5.6; confidence Interval 1.1-27.4).	22018204
Encephalitis	Stem Cell Exhaustion	EBV seems to be associated with encephalitis in stem cell transplant recipients.	22018204
Malignant neoplasm of stomach, Specialty Type - cancer	Stem Cell Exhaustion	Combination of epithelial-mesenchymal transition and cancer stem cell-like phenotypes has independent prognostic value in gastric cancer.	22018628
Malignant neoplasm of stomach	Stem Cell Exhaustion	To demonstrate the clinical significance of epithelial-mesenchymal transition and stem cell-like phenotypes in gastric cancer, we performed immunohistochemistry for 5 epithelial-mesenchymal transition-related proteins, including Snail-1, ZEB-1, E-cadherin, vimentin, and b-catenin, and the gastric cancer stem cell marker CD44 in 276 consecutive primary gastric cancers and 54 matched lymph node metastases.	22018628
Malignant neoplasm of stomach	Stem Cell Exhaustion	The known gastric cancer stem cell maker, CD44, was significantly associated with the protein expression of Snail-1, ZEB-1, and E-cadherin (P < .05).	22018628
Aggressive behavior, Primary malignant neoplasm	Stem Cell Exhaustion	A combination of epithelial-mesenchymal transition and stem cell-like phenotypes is an important predictor of aggressive biologic behavior and has an independent prognostic value in predicting outcomes of primary gastric cancer.	22018628
Bladder Neoplasm, Neoplasms	Stem Cell Exhaustion	We experienced a case of urinary bladder tumor diagnosed as osteoclastic-rich undifferentiated carcinoma, and performed an immunohistochemical study on the expression of various markers, including stem cell markers to further characterize the tumor properties.	22019007
Hormone refractory prostate cancer	Stem Cell Exhaustion	Phase I rapid dose-escalation study of AGS-1C4D4, a human anti-PSCA (prostate stem cell antigen) monoclonal antibody, in patients with castration-resistant prostate cancer: a PCCTC trial.	22020316
Malignant neoplasm of prostate	Stem Cell Exhaustion	AGS-1C4D4 is a human monoclonal antibody against prostate stem cell antigen (PSCA), a cell-surface protein expressed by most prostate cancers.	22020316
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Hematopoietic stem cell transplant following remission induction chemotherapy including gemtuzumab ozogamicin is a feasible and effective treatment option in elderly patients with acute myeloid leukemia.	22023488
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This study analyzed the results of stem cell transplant (SCT) in elderly patients with acute myeloid leukemia (AML) who achieved complete remission (CR) with a gemtuzumab ozogamicin (GO)-containing regimen in order to identify the impact of the drug as a remission induction regimen on the outcome of SCT.	22023488
Multiple Myeloma	Stem Cell Exhaustion	The prognostic impact of chromosomal abnormalities was evaluated by fluorescence in situ hybridization with cytoplasmic immunoglobulin light chain staining (cIg-FISH) and by classical metaphase cytogenetics in a cohort of 207 patients with newly diagnosed multiple myeloma who were treated with high-dose therapy followed by autologous stem cell transplantation in the CMG2002 clinical trial.	22023516
Multiple Myeloma	Stem Cell Exhaustion	In conclusion, complex karyotype, gain of 1q21 region and translocation t(4;14) are major prognostic factors associated with reduced survival of patients with newly diagnosed multiple myeloma treated with autologous stem cell transplantation.	22023516
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	High-dose therapy and autologous stem cell transplant for transformed non-Hodgkin lymphoma in the rituximab era.	22023518
Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	The impact of rituximab on the outcome of high-dose therapy and autologous stem cell transplant (HD-ASCT) for transformed non-Hodgkin lymphoma (NHL) has not been previously described.	22023518
Primary central nervous system lymphoma	Stem Cell Exhaustion	Upfront thiotepa, busulfan, cyclophosphamide, and autologous stem cell transplantation for primary CNS lymphoma: a single centre experience.	22023529
Primary central nervous system lymphoma	Stem Cell Exhaustion	In an attempt to improve upon these poor results, we treated 21 patients with PCNSL aged 34-69 years (median 56) with high-dose thiotepa, busulfan, cyclophosphamide (TBC) and autologous stem cell transplant (ASCT) as part of front-line therapy, without WBRT.	22023529
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Heterogeneity of leukemia stem cell candidates at diagnosis of acute myeloid leukemia and their clinical significance.	22024109
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Leukemia stem cell candidates (LSCC) can be enriched from patients with acute myeloid leukemia by high aldehyde dehydrogenase (ALDH) activity and CD34 expression.	22024109
Cytomegalovirus Infections	Stem Cell Exhaustion	Valganciclovir as pre-emptive therapy for cytomegalovirus infection in allogeneic haematopoietic stem cell transplant recipients.	22024510
Communicable Diseases	Stem Cell Exhaustion	In haematopoietic stem cell transplant (HSCT) recipients, cytomegalovirus (CMV) infection contributes significantly to morbidity and mortality in both the early and late post-transplant period.	22024510
Malignant Neoplasms	Stem Cell Exhaustion	Polycomb group (PcG) proteins are critical epigenetic mediators of stem cell pluripotency, which have been implicated in the pathogenesis of human cancers.	22028491
Pulmonary Complication	Stem Cell Exhaustion	Pulmonary function testing prior to reduced intensity conditioning allogeneic stem cell transplantation in an unselected patient cohort predicts posttransplantation pulmonary complications and outcome.	22031451
Hodgkin Disease	Stem Cell Exhaustion	The prognosis of patients with relapsed Hodgkin's lymphoma, especially those who relapse after stem-cell transplantation, is poor, and the development of new agents for this patient population is an unmet medical need.	22033282
Hodgkin Disease	Stem Cell Exhaustion	Successful administration of rituximab-bendamustine regimen in the relapse of Hodgkin lymphoma after autologous hemopoietic stem cell transplantation.	22034208
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	Treatment options for relapsing Hodgkin lymphoma (HL) are controversial after autologous hemopoietic stem cell transplantation (HSCT).	22034208
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Four years previous to his admission to our hospital, he developed acute myelocytic leukemia and he was implanted with peripheral blood stem cell transplantation.	22036822
Neutropenia	Stem Cell Exhaustion	We have used a mathematical model of the combined dynamics of the hematopoietic stem cells and the differentiated neutrophil progeny to examine the effects of periodic chemotherapy in generating neutropenia, and the corresponding response of this system to granulocyte colony stimulating factor given to counteract the neutropenia.	22037060
Specialty Type - cancer	Stem Cell Exhaustion	Furthermore, neoplastic transformation involves senescence evasion, and is associated with an increased number of putative cancer stem cells.	22037217
Childhood Breast Carcinoma	Stem Cell Exhaustion	Distinct patterns of promoter CpG island methylation of breast cancer subtypes are associated with stem cell phenotypes.	22037257
Childhood Breast Carcinoma	Stem Cell Exhaustion	Although DNA methylation profiles in breast cancer have been connected to breast cancer molecular subtype, there have been no studies of the association of DNA methylation with stem cell phenotype.	22037257
Childhood Breast Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	This study was designed to evaluate the promoter CpG island methylation of 15 genes in relation to breast cancer subtype, and to investigate whether the patterns of CpG island methylation in each subtype are associated with their cancer stem cell phenotype represented by CD44+/CD24- and ALDH1 expression.	22037257
SCGB3A1 gene, Atrial Premature Complexes, Childhood Breast Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	We performed MethyLight analysis of the methylation status of 15 promoter CpG island loci involved in breast cancer progression (APC, DLEC1, GRIN2B, GSTP1, HOXA1, HOXA10, IGF2, MT1G, RARB, RASSF1A, RUNX3, SCGB3A1, SFRP1, SFRP4, and TMEFF2) and determined cancer stem cell phenotype by CD44/CD24 and ALDH1 immunohistochemistry in 36 luminal A, 33 luminal B, 30 luminal-HER2, 40 HER2 enriched, and 40 basal-like subtypes of breast cancer.	22037257
Childhood Breast Carcinoma, Malignant neoplasm of breast, Neoplasms	Stem Cell Exhaustion	Our findings showed that promoter CpG island methylation was different in relation to breast cancer subtype and stem cell phenotype of tumor, suggesting that breast cancers have distinct patterns of CpG island methylation according to molecular subtypes and these are associated with different stem cell phenotypes of the tumor.	22037257
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Post-transplant lymphoproliferative disorder (PTLD) is a fatal complication of allogeneic hematopoietic stem cell transplantation (HSCT) that is caused by reactivation of Epstein-Barr virus (EBV).	22038015
methyldopa	Stem Cell Exhaustion	Retinal pigment epithelium (RPE) cells derived from human embryonic stem cells (hES-RPE) and cultured fetal and aged adult RPE were seeded onto the inner collagenous layer of submacular BM-choroid-sclera explants generated from aged and AMD human donor eyes.	22039244
Ischemia	Stem Cell Exhaustion	Early endothelial progenitor cells in bone marrow are a biomarker of cell therapy success in patients with critical limb ischemia.	22040109
CLU protein, human, Ischemia	Stem Cell Exhaustion	Early and late endothelial progenitor cells (CFU-EC and ECFC) were cultivated and quantified according to published methods in peripheral blood and BM-MNC from patients with critical limb ischemia (CLI; n = 11) enrolled in the OPTIPEC trial ( http://clinicaltrials.gov/ct2/show/NCT00377897 ) to receive BM-MNC as a cell therapy product.	22040109
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	To elucidate the presence of this family on acute lymphoblastic leukemia (ALL), as well as its relationship with the leukemia-initiating potential, we analyzed the expression pattern of this family members on human ALL progenitor cells, combined with serial xenotransplantation assay.	22040559
Leukemic Blast Count	Stem Cell Exhaustion	SLAM family members are present on B-ALL progenitor cells and the leukemia-initiating potential of leukemic blasts is correlated negatively with the proportion of CD(150)(+) cells, the percentage of which can serve as a useful predictor for engraftment success of B-ALL to immune deficient mice.	22040559
Infection	Stem Cell Exhaustion	During their index admission, patients who were subsequently readmitted had more documented infections (P < .001), higher hematopoietic cell transplantation comorbidity index (HCT-CI) (P < .01), total body irridiation (TBI)-based conditioning (P < .001), unrelated donor (P < .001), and peripheral stem cell (P = .014) transplantation.	22040844
Myeloproliferative disease, MYELODYSPLASTIC SYNDROME, Myeloid Leukemia, Chronic, Chronic myeloproliferative disorder, Acute lymphocytic leukemia	Stem Cell Exhaustion	The conventional cytogenetic test and detection of BCR/ABL fusion gene by FISH for bone marrow of patients with newly diagnosed chronic myeloproliferative disease or myelodysplastic and myeloproliferative disorders, acute lymphocytic leukemia and chronic myelogenous leukemia (CML) after allogeneic hematopoietic stem cell transplantation were carried out.	22040989
Myeloproliferative disease, MYELODYSPLASTIC SYNDROME, Myeloid Leukemia, Chronic, Chronic myeloproliferative disorder, Acute lymphocytic leukemia	Stem Cell Exhaustion	The results showed that (1) out of 46 newly diagnosed as chronic myeloproliferative disease or myelodysplastic and myeloproliferative disorders, 22 cases were diagnosed as CML, the FISH detection showed all positive (100%), while cytogenetic test showed 86.4% (19/22) positive, in the other 24 patients who were diagnosed as other chronic myeloproliferative disease or myelodysplastic and myeloproliferative disorders, BCR/ABL fusion gene all were be detected as negative 100% by FISH, while the cytogenetic test of bone marrow in 3 cases supported the diagnosis of CML, and the diagnosis of myelodysplastic disorder in 1 case; (2) in 3 out of 7 acute lymphocytic leukemia cases the BCR/ABL fusion gene could not be detected by FISH; (3) the BCR/ABL fusion gene could be detected by FISH in 2 cases of CML received allogeneic hematopoietic stem cell transplantation, with abnormal threshold 6.5% and 1.2% respectively.	22040989
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	This method also has an important significance for monitor of minimal residual disease in CML patients received allogeneic hematopoietic stem cell transplantation.	22040989
Acute lymphocytic leukemia	Stem Cell Exhaustion	Outcome of medium-dose VP-16/CY/TBI superior to CY/TBI as a conditioning regimen for allogeneic stem cell transplantation in adult patients with acute lymphoblastic leukemia.	22042561
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	The choice of conditioning regimen before allogeneic stem cell transplantation (SCT) in patients with acute lymphoblastic leukemia (ALL) is important.	22042561
Communicable Diseases	Stem Cell Exhaustion	An in vitro study confirmed the enhanced neurogenesis of mouse neural stem cells by direct AAV2/1-FGF2 infection in an Ab oligomer-sensitive manner.	22042871
Childhood Breast Carcinoma	Stem Cell Exhaustion	The samples in cluster 1 also share many features with the newly identified claudin-low breast cancer intrinsic subtype, which also shows characteristics of stromal and stem cells.	22044755
Gastrointestinal symptom	Stem Cell Exhaustion	Human herpesvirus 6 in biopsies from patients with gastrointestinal symptoms after allogeneic stem cell transplantation.	22048789
Gastrointestinal complication	Stem Cell Exhaustion	Gastrointestinal complications are frequent after allogeneic stem cell transplantation (allo-SCT).	22048789
Disease, trauma qualifier	Stem Cell Exhaustion	Non-embryonic stem cells have the potential for being used in therapeutic attempts to develop treatments for human diseases and injuries.	22049618
Degenerative polyarthritis, Burn injury, Rheumatoid Arthritis, Diabetes, Cerebrovascular accident, Spinal Cord Injuries, Heart Diseases, Parkinson Disease	Stem Cell Exhaustion	Simple, secure methods to isolate non-embryonic stem cells from different tissues is one step towards making those treatments available to people suffering from Parkinson's disease, spinal cord injury, stroke, burns, heart disease, diabetes, osteoarthritis, and rheumatoid arthritis.	22049618
Specialty Type - cancer, Squamous cell carcinoma of esophagus	Stem Cell Exhaustion	An immunohistochemical analysis of cancer stem cell markers, such as nucleostemin and TWIST has not been conducted in surgically-resected esophageal squamous cell carcinomas after neoadjuvant chemotherapy.	22050045
Neoplasms	Stem Cell Exhaustion	More specifically, cells that constitutively express elevated levels of nucleostemin exhibit increased TWIST expression; expression of genes that induced pluripotent stem cells; enhanced radioresistance; tumor formation, even when small numbers of cells are implanted; and an increased propensity to metastasize.	22050045
Precursor T cell lymphoblastic leukemia/lymphoblastic lymphoma	Stem Cell Exhaustion	Distinct immunophenotype of early T-cell progenitors in T lymphoblastic leukemia/lymphoma may predict FMS-like tyrosine kinase 3 mutations.	22050963
Amyloidosis	Stem Cell Exhaustion	All patients with light-chain amyloidosis received chemotherapy in the interval between OHT and autologous hematopoietic stem cell transplant.	22051505
Amyloidosis	Stem Cell Exhaustion	A novel strategy of OHT, followed by light-chain suppressive chemotherapy before autologous hematopoietic stem cell transplant, is feasible for patients with light-chain amyloidosis.	22051505
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Adventitial delivery of an allogeneic bone marrow-derived adherent stem cell in acute myocardial infarction: phase I clinical study.	22052917
Acute myocardial infarction	Stem Cell Exhaustion	MultiStem is an allogeneic bone marrow-derived adherent adult stem cell product that has shown efficacy in preclinical models of acute myocardial infarction (AMI).	22052917
Special Handling Code - Dry	Stem Cell Exhaustion	Comparison of stem cell sources in the severity of dry eye after allogeneic haematopoietic stem cell transplantation.	22053104
Dry Eye Syndromes	Stem Cell Exhaustion	To compare the incidence and severity of dry eye (DE) after allogeneic haematopoietic stem cell transplantation (HSCT) according to the stem cell source.	22053104
Lymphoid, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Successful treatment of lymphoid blastic crisis in chronic myelogenous leukemia with the additional bcr/abl transcript using imatinib-combined chemotherapy and high-dose chemotherapy with allogeneic bone marrow stem cell transplantation.	22057509
Neutropenia, Hematologic Neoplasms, Mycoses	Stem Cell Exhaustion	Based on the high negative predictive value of this diagnostic and therapeutic approach in persistent febrile neutropenia patients with hematologic malignancies or patients who have received a hematopoietic stem cell transplant, the approach is useful for identifying patients who are not likely to develop invasive fungal infection and do not, therefore, require antifungal therapy.	22058202
Multiple Myeloma	Stem Cell Exhaustion	Cyclophosphamide, thalidomide, and dexamethasone as induction therapy for newly diagnosed multiple myeloma patients destined for autologous stem-cell transplantation: MRC Myeloma IX randomized trial results.	22058209
Myelosuppression, Multiple Myeloma	Stem Cell Exhaustion	Thalidomide is active in multiple myeloma and is associated with minimal myelosuppression, making it a good candidate for induction therapy prior to high-dose therapy with autologous stem-cell transplantation.	22058209
Multiple Myeloma	Stem Cell Exhaustion	Younger donor's age and upfront tandem are two independent prognostic factors for survival in multiple myeloma patients treated by tandem autologous-allogeneic stem cell transplantation: a retrospective study from the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire (SFGM-TC).	22058218
Multiple Myeloma	Stem Cell Exhaustion	How tandem autologous-allogeneic stem cell transplantation should be integrated in the treatment of multiple myeloma remains controversial.	22058218
Multiple Myeloma	Stem Cell Exhaustion	We examined the long-term outcome of patients with multiple myeloma managed with tandem autologous-allogeneic stem cell transplantation and present a prognostic factor analysis based on the experience of the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire (SFGM-TC).	22058218
Multiple Myeloma	Stem Cell Exhaustion	Benefit from autologous stem cell transplantation in primary refractory myeloma?	22058223
Multiple Myeloma	Stem Cell Exhaustion	Several studies of autologous stem cell transplantation in primary refractory myeloma have produced encouraging results.	22058223
Nephroblastoma	Stem Cell Exhaustion	Renal function after tandem high-dose chemotherapy and autologous stem cell transplantation in children with Wilms tumor.	22060039
Multiple Myeloma	Stem Cell Exhaustion	Second autologous stem cell transplantation as salvage therapy for multiple myeloma: impact on progression-free and overall survival.	22062804
Multiple Myeloma	Stem Cell Exhaustion	The role of a second autologous stem cell transplant (ASCT) as salvage therapy is unclear, particularly with the availability of novel agents to treat progressive multiple myeloma (MM).	22062804
Skeletal muscle structure, muscle cell proliferation	Stem Cell Exhaustion	It inhibits muscle stem cell proliferation and differentiation and attenuates adult muscle fiber protein accretion, resulting in decreased skeletal muscle mass.	22068480
Secondary malignant neoplasm of liver, Specialty Type - cancer	Stem Cell Exhaustion	Prognostic value of putative circulating cancer stem cells in patients undergoing hepatic resection for colorectal liver metastasis.	22071867
Malignant tumor of colon	Stem Cell Exhaustion	Univariate analysis of the expression levels of CD133 (a marker of colon cancer stem cells) and survivin (an antiapoptotic factor) resulted in statistically significant association with patient survival [hazard ratio (HR) 2.7, 95% confidence interval (CI) 1.9-3.7, P < 0.0001; and hazard ratio 2.1, 95% CI 1.4-3.2, P < 0.0001, respectively].	22071867
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	The application of allogeneic hematopoietic stem cell transplantation (HSCT) is limited by life-threatening complications such as severe or acute graft-versus-host disease (GVHD).	22073847
Parkinson Disease	Stem Cell Exhaustion	In this study, we examined the subventricular zone of 10 patients with Parkinson's disease and 10 age- and sex-matched controls for proliferation and neural stem cell numbers.	22075520
Parkinsonian Disorders, Parkinson Disease	Stem Cell Exhaustion	In summary, the adult neural stem cell pool in the subventricular zone was not clearly affected in the human parkinsonian brain or a Parkinson's disease mouse model.	22075520
Impaired, Parkinson Disease	Stem Cell Exhaustion	An impairment in neurogenesis may have negative consequences for the development of new therapeutic approaches in Parkinson's disease, as neural stem cells are a potential source for endogenous repair.	22075520
Parkinson Disease	Stem Cell Exhaustion	Additionally, we were able to culture neural stem cells from post-mortem brain of several patients with Parkinson's disease, confirming the presence of viable neural stem cells in these brains.	22075520
Parkinsonian Disorders	Stem Cell Exhaustion	Thus, we conclude that the number of adult neural stem cells is probably not diminished in the parkinsonian brain and that dopamine depletion most likely has no effect on human neural stem cells.	22075520
Parkinson Disease	Stem Cell Exhaustion	The induction of rat spermatogonial stem cells into neuronal-like cells and behavioral recovery following transplantation in a rat Parkinson's disease model.	22075704
Injury of kidney, Amyloidosis	Stem Cell Exhaustion	Acute kidney injury during leukocyte engraftment after autologous stem cell transplantation in patients with light-chain amyloidosis.	22076913
Exanthema, Fever, Engraftment syndrome, Non-cardiogenic pulmonary edema	Stem Cell Exhaustion	Engraftment syndrome (ES) is a complication of hematopoietic stem cell transplantation characterized by fever, rash, and non-cardiogenic pulmonary edema.	22076913
Kidney Failure, Acute, Amyloidosis	Stem Cell Exhaustion	We have noted a high incidence of AKI in patients with immunoglobulin light-chain amyloidosis (AL) undergoing autologous stem cell transplant (ASCT) around the time of leukocyte engraftment.	22076913
Cytomegalovirus Infections, Lymphoma	Stem Cell Exhaustion	The potential role of pre-transplant HBcIgG seroposivity as predictor of clinically relevant cytomegalovirus infection in patients with lymphoma undergoing autologous hematopoietic stem cell transplantation: a study from the Rome Transplant Network.	22076952
Lymphoma, Communicable Diseases	Stem Cell Exhaustion	Despite the increased use of intensive immunosuppressive chemo-immunotherapies in patients with lymphoma observed in the last decade, current data on cytomegalovirus (CMV) infection following autologous stem cell transplantation (Auto-SCT) are very limited.	22076952
Ischemia	Stem Cell Exhaustion	Therapeutic angiogenesis in patients with severe limb ischemia by transplantation of a combination stem cell product.	22079876
Malignant neoplasm of ovary, Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	As a putative marker for cancer stem cells in human malignant tumors, including ovarian cancer, CD133 expression may define a tumor-initiating subpopulation of cells and is associated with the clinical outcome of patients.	22080056
Malignant neoplasm of ovary, Specialty Type - cancer	Stem Cell Exhaustion	Our results thus show that CD133 expression is a predictor of poor clinical outcome for patients with ovarian cancer, supporting the proposed link between CD133 and cancer stem cells.	22080056
Secondary Neoplasm	Stem Cell Exhaustion	During tumorigenesis, epithelial to mesenchymal transition promotes invasion and metastasis and has been linked to the presence of stem cells.	22080057
Malignant neoplasm of ovary, Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cell and embryonic development-associated molecules contribute to prognostic significance in ovarian cancer.	22080880
Specialty Type - cancer	Stem Cell Exhaustion	Embryonic molecules and cancer stem cell signaling resemble each other, and they organize cancer modality.	22080880
Hodgkin Disease, Lymphoma, Non-Hodgkin, Multiple Myeloma	Stem Cell Exhaustion	European data on stem cell mobilization with plerixafor in non-Hodgkin's lymphoma, Hodgkin's lymphoma and multiple myeloma patients.	22080971
Specialty Type - cancer	Stem Cell Exhaustion	Nucleostemin (NS), a nucleolar GTPase, is highly expressed in stem/progenitor cells and in most cancer cells.	22081066
Infection, Hypogammaglobulinemia	Stem Cell Exhaustion	Patients undergoing allogeneic hematopoietic stem cell transplant (allo HCT) have a higher incidence of infections partly due to secondary hypogammaglobulinemia.	22081487
Graft-vs-Host Disease, Malignant neoplasm of skin	Stem Cell Exhaustion	Recipients of hematopoietic stem cell transplantation (HSCT) have a greater risk of skin cancer; chronic graft versus host disease (GVHD) is an additional risk factor.	22085032
Sample Size Calculation	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPC), circulating endothelial cells and serum levels of placental growth factor (PlGF), soluble vascular adhesion molecule and vascular endothelial growth factor were measured in a prospective cohort of 100 SSc patients.	22085793
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	JmjC-domain containing histone demethylase 1B-mediated p15(Ink4b) suppression promotes the proliferation of leukemic progenitor cells through modulation of cell cycle progression in acute myeloid leukemia.	22086844
Myeloproliferative disease	Stem Cell Exhaustion	ET is a clonal stem cell disorder that is often associated with JAK2 mutations and shares phenotypic and pathogenetic similarities with other myeloproliferative neoplasms.	22088920
Coronary Vessel Bifurcation Lesion	Stem Cell Exhaustion	Thus, aim of the present study was to evaluate the angiographic and clinical results of a new type of stent (coated with murine monoclonal antihuman CD34 antibodies designed to attract circulating endothelial progenitor cells to rapidly establish a functional endothelial layer and promote healing stent implantation) in a cohort of consecutive patients with coronary bifurcation lesions.	22089276
Hematopoietic Neoplasms, Loss	Stem Cell Exhaustion	Analysis of hematopoietic stem cell transplant engraftment: use of loss or gain of microsatellite alleles to identify residual hematopoietic malignancy.	22089346
Neoplasms, leukemia	Stem Cell Exhaustion	In the peripheral blood or bone marrow of 4 hematopoietic stem cell transplantation patients with leukemia or lymphoma, we identified tumor DNA on the basis of STR loci showing copy number alteration.	22089346
Ann Arbor Stage I Nasal Type NK/T-Cell Lymphoma	Stem Cell Exhaustion	We report the first case of successful treatment with chemoradiotherapy and autologous stem cell transplantation in a patient with a primary spinal NK/T-cell lymphoma.	22089400
Hematopoietic stem cells, PAFAH1B1 wt Allele, leukemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is a clonal haematopoietic stem cell disorder characterized by ineffective haematopoiesis and leukaemia progression.	22089606
Immunocompromised Host	Stem Cell Exhaustion	In 24 patients for whom clinical data were available, results from the 16S rRNA sequencing method led to treatment change in 14 immunocompromised patients (including 7 hematopoietic stem cell recipients and 1 liver transplant recipient).	22093075
Optic Neuritis	Stem Cell Exhaustion	Presumed cytomegalovirus-associated retrobulbar optic neuritis in a patient after allogeneic stem cell transplantation.	22093546
Optic Neuritis	Stem Cell Exhaustion	A case of cytomegalovirus (CMV)-associated bilateral retrobulbar optic neuritis (ON) following haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is reported.	22093546
Immunocompromised Host, Communicable Diseases	Stem Cell Exhaustion	There are several reports in the literature of M. marinum infection in immunocompromised hosts, including those with solid organ transplants, but none in patients who have received stem cell transplants (SCTs).	22093773
Liver carcinoma	Stem Cell Exhaustion	MRI features of hepatocellular carcinoma expressing progenitor cell markers.	22097930
Liver carcinoma, HCCS gene	Stem Cell Exhaustion	To determine whether magnetic resonance (MR) imaging features differ between hepatocellular carcinomas (HCCs) with and without expression of progenitor cell markers, such as cytokeratin (CK) 19 and epithelial cell adhesion molecule (EpCAM).	22097930
Specialty Type - cancer, Squamous cell carcinoma of esophagus, Secondary Neoplasm	Stem Cell Exhaustion	Cancer stem cell marker ALDH1 expression is associated with lymph node metastasis and poor survival in esophageal squamous cell carcinoma: a study from high incidence area of northern China.	22098156
Specialty Type - cancer, Aggressive behavior, Neoplasms	Stem Cell Exhaustion	Cancer stem cell (CSC) may be responsible for tumor growth and maintenance of aggressive behavior.	22098156
Stable chronic Graft vs Host Disease, Infection	Stem Cell Exhaustion	Aiming to determine the impact of lymphocyte subsets on cGVHD, blood samples from 98 patients at least 100 days following allogeneic haematopoietic stem cell transplantation (median 1066 days) were analyzed, serum levels of immunoglobulins measured and the incidence of severe infections retrospectively documented.	22098606
Adult Glioblastoma, Specialty Type - cancer	Stem Cell Exhaustion	Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethane-short branch PEI.	22098779
Malignant - descriptor, Specialty Type - cancer	Stem Cell Exhaustion	CD133 has been considered a putative marker of cancer stem cells (CSCs) in malignant cancers, including GBMs.	22098779
melanoma, Specialty Type - cancer	Stem Cell Exhaustion	Correlates of BBCAM use included cancer type (bowel [OR=3.3; CI:1.8-5.9], breast [OR=2.4; CI:1.4-4.1], head and neck [OR=3.8; CI: 2.0-7.2], haematological [OR=2.0; CI: 1.1-3.7], prostate [OR=1.8; CI: 1.0-3.9] versus melanoma), education level (university degree [OR=1.6; CI:1.1-2.3] versus secondary school) and treatment types (chemotherapy [OR=2.0; CI:1.4-2.7] versus not, bone marrow/stem cell transplant/immunotherapy [OR=2.3; CI:1.2-4.4] versus not).	22100734
Specialty Type - cancer	Stem Cell Exhaustion	Moreover, it is a marker for cancer stem cells (CSC).	22101256
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	BCR-ABL overexpression and stem cell quiescence supposedly contribute to the failure of imatinib mesylate (IM) to eradicate chronic myeloid leukemia (CML).	22101898
Mantle cell lymphoma	Stem Cell Exhaustion	Detection of minimal residual disease following induction immunochemotherapy was an independent predictor of time to progression following immunochemotherapy and autologous stem cell transplantation for mantle cell lymphoma.	22102709
Hematopoietic Neoplasms, Opportunistic Infections	Stem Cell Exhaustion	The number of patients with haematopoietic malignancies receiving chemotherapy and stem-cell transplantation has increased the incidence of severe opportunistic infections.	22103628
Parkinson Disease	Stem Cell Exhaustion	We present two case studies where this software is currently being used to build repositories of genomics experiments - one contains data from hematopoietic stem cells and another from Parkinson's disease patients.	22103807
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Early remodeling processes as predictors of diastolic function 5 years after reperfused acute myocardial infarction and intracoronary progenitor cell application.	22105229
Infarction	Stem Cell Exhaustion	Adverse early remodeling processes (reflected by LV dilatation between infarction and 4 months) determine long-term diastolic function in patients after reperfused AMI and progenitor cell therapy.	22105229
Cocaine-Related Disorders	Stem Cell Exhaustion	Somatic cells reprogrammed into induced pluripotent stem cells (iPSCs) acquire features of human embryonic stem cells (hESCs) and thus represent a promising source for cellular therapy of debilitating diseases, such as age-related disorders.	22110631
Malignant neoplasm of breast, Neoplasms	Stem Cell Exhaustion	Breast cancers from BRCA mutation carriers do not harbor more ALHD-1 positive cells than sporadic tumors, and their more aggressive phenotype can thus not be explained by an increased stem cell pool.	22111833
Childhood Breast Carcinoma	Stem Cell Exhaustion	Presence of intratumoral stem cells in breast cancer patients with or without BRCA germline mutations.	22111833
Non-Malignant	Stem Cell Exhaustion	While mammary stem cells were also detected in non-malignant breast lesions, only 41% of the tissues contained ALDH-1 positive cells (p=0.0371, Chi Square test).	22111833
Neoplasms	Stem Cell Exhaustion	We have investigated the presence of mammary stem / progenitor cells in normal tissues and in tumor tissues obtained from women with and without BRCA1/2 germline mutations by utilizing ALDH-1 immunohistochemistry.	22111833
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	Cancer stem cell markers in breast cancer: pathological, clinical and prognostic significance.	22112299
Specialty Type - cancer, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	The cancer stem cell (CSC) hypothesis states that tumours consist of a cellular hierarchy with CSCs at the apex driving tumour recurrence and metastasis.	22112299
Hematological Disease, Malignant Neoplasms	Stem Cell Exhaustion	Cases were analyzed for time from diagnosis to referral, age, race, gender, socioeconomic status, antecedent hematologic disorder, cytotoxic or radiation therapy for prior malignancy, karyotype, fms-like tyrosine kinase receptor-3 (FLT3) mutations, intensive chemotherapy, clinical trial participation, hematopoietic stem cell transplantation (HSCT) and overall survival (OS).	22112974
Multiple Myeloma	Stem Cell Exhaustion	18F-FDG PET/CT for detection and localization of residual or recurrent disease in patients with multiple myeloma after stem cell transplantation.	22113619
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The aim of the study was to determine the diagnostic performance of (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT for the detection and localization of residual or recurrent disease in patients with multiple myeloma (MM) after stem cell transplantation.	22113619
hyperfunction, Aspergillosis	Stem Cell Exhaustion	Genetically-determined hyperfunction of the S100B/RAGE axis is a risk factor for aspergillosis in stem cell transplant recipients.	22114731
Aspergillosis	Stem Cell Exhaustion	Invasive aspergillosis (IA) is a major threat to the successful outcome of hematopoietic stem cell transplantation (HSCT), although individual risk varies considerably.	22114731
Non-Small Cell Lung Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	A tissue microarray representing 248 clinically annotated stage I-II NSCLC cases was stained using immunohistochemistry (IHC) and scored for HHSP proteins namely, SHH, PTCH1, SMO, GLI1, and GLI2; as well as, ALDH1A1, a putative cancer stem cell marker.	22115706
Primary central nervous system lymphoma	Stem Cell Exhaustion	Long-term follow-up of high-dose chemotherapy with autologous stem-cell transplantation and response-adapted whole-brain radiotherapy for newly diagnosed primary CNS lymphoma: results of the multicenter Ostdeutsche Studiengruppe Hamatologie und Onkologie OSHO-53 phase II study.	22115927
Primary central nervous system lymphoma, Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	We previously reported the results of a phase II study for patients with newly diagnosed primary central nervous system lymphoma treated with autologous peripheral blood stem-cell transplantation (aPBSCT) and response-adapted whole-brain radiotherapy (WBRT).	22115927
leukemia	Stem Cell Exhaustion	Hematopoietic stem cell transplantation in T-prolymphocytic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation and the Royal Marsden Consortium.	22116553
Coronary Arteriosclerosis	Stem Cell Exhaustion	Predictors of circulating endothelial progenitor cell levels in patients without known coronary artery disease referred for multidetector computed tomography coronary angiography.	22118125
Diabetes, Coronary Arteriosclerosis	Stem Cell Exhaustion	Relation between the frequency of CD34+ bone marrow derived circulating progenitor cells and the number of diseased coronary arteries in patients with myocardial ischemia and diabetes.	22118372
Coronary heart disease	Stem Cell Exhaustion	Bone marrow-derived circulating progenitor cells (BM-CPCs) in patients with coronary heart disease are impaired with respect to number and mobilization.	22118372
SERPINB3 wt Allele, Specialty Type - cancer, Squamous cell carcinoma	Stem Cell Exhaustion	The utility of CD44, CD117 and CD133 in identification of cancer stem cells (CSC) in oral squamous cell carcinomas (OSCC).	22119814
Neoplasms, Specialty Type - cancer, Carcinogenesis	Stem Cell Exhaustion	One of the theories regarding oral carcinogenesis is that the tumor growth is dependent on cancer stem cells (CSCs) that have the capacity of self-renewal and of giving rise to more differentiated tumor cells, like the stem cells do in normal tissues.	22119814
Childhood Breast Carcinoma	Stem Cell Exhaustion	This shows that the relationship between basic cell biology and clinical behaviour is not always straightforward and warrants further investigations of the true clinical impact of breast cancer stem cells.	22119938
Peripheral Arterial Diseases	Stem Cell Exhaustion	Number of endothelial progenitor cells in peripheral artery disease as a marker of severity and association with pentraxin-3, malondialdehyde-modified low-density lipoprotein and membrane type-1 matrix metalloproteinase.	22123215
Heart failure, Coronary Arteriosclerosis, Vascular System Injuries, Corneal Endothelial Cell Loss	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPCs) were mobilized in cardiac ischemia, heart failure and vascular injuries associated with endothelial damage.	22123215
Bacteremia, Meningitis	Stem Cell Exhaustion	A 53-year-old stem cell transplant recipient with meningitis and bacteremia.	22124018
Multiple Myeloma	Stem Cell Exhaustion	A 71-year-old woman with multiple myeloma status after stem cell transplantation.	22125317
granulocyte, Cervical Intraepithelial Neoplasia, Adult chronic idiopathic neutropenia	Stem Cell Exhaustion	Chronic idiopathic neutropenia (CIN) is a granulocytic disorder characterized by increased apoptosis of the bone marrow (BM) granulocytic progenitor cells and an inflammatory BM microenvironment.	22127462
Multiple Myeloma	Stem Cell Exhaustion	High-risk cytogenetics and persistent minimal residual disease by multiparameter flow cytometry predict unsustained complete response after autologous stem cell transplantation in multiple myeloma.	22128143
Multiple Myeloma	Stem Cell Exhaustion	The achievement of complete response (CR) after high-dose therapy/autologous stem cell transplantation (HDT/ASCT) is a surrogate for prolonged survival in multiple myeloma; however, patients who lose their CR status within 1 year of HDT/ASCT (unsustained CR) have poor prognosis.	22128143
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	According to the cancer stem cell (CSC) hypothesis, only a small subset of tumor cells has the ability to initiate and develop tumor growth.	22130902
SERPINB3 wt Allele, Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	MiRNA expression and DNA methylation changes were also investigated in FACS sorted CD44(high) oral cancer stem cells from primary tumor samples (CSCs), and in oral rinse and saliva from 15 OSCC patients and 7 healthy volunteers.	22132151
Pneumonitis, CTCAE	Stem Cell Exhaustion	Risk factors for development of pneumonitis after high-dose chemotherapy with cyclophosphamide, BCNU and etoposide followed by autologous stem cell transplant.	22132836
Pneumonitis, CTCAE	Stem Cell Exhaustion	Pneumonitis is a complication of high-dose chemotherapy and autologous stem cell transplant (HDC-ASCT) regimens containing BCNU.	22132836
Hematologic Neoplasms, Acute GVH disease	Stem Cell Exhaustion	We examined the levels of 33 cytokines in relation to peri- and post-transplant events such as conditioning regimen, chimerism, and acute graft-versus-host disease in myeloablative, non-T cell-replete HLA-identical sibling donor stem cell transplantation for hematologic malignancies.	22133778
Aniridia, Burn injury	Stem Cell Exhaustion	Primary KPro procedures were performed in 23% of eyes for limbal stem cell deficiency secondary to chemical burns and aniridia and for herpetic disease.	22134402
Gastric Adenocarcinoma	Stem Cell Exhaustion	Clinicopathologic significance of putative stem cell markers, CD44 and nestin, in gastric adenocarcinoma.	22135720
Malignant neoplasm of stomach	Stem Cell Exhaustion	This is the first study to report the clinicopathologic significance of nestin expression in gastric cancers, and to correlate the nestin expression with CD44, another stem cell marker.	22135720
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells (CSC) are unique subpopulations that have the capacity to drive malignant progression and mediate radio/chemoresistance.	22135720
Lymphoma	Stem Cell Exhaustion	Patterns of social support among lymphoma patients considering stem cell transplantation.	22136347
Lymphoma	Stem Cell Exhaustion	We evaluated the forms of social support available for patients with relapsed lymphoma considering stem cell transplantation and examined the influence of support on treatment delay.	22136347
T-Cell Lymphoma, allogeneic hematopoietic stem cell transplant with purging	Stem Cell Exhaustion	Long-term survival in patients with peripheral T-cell non-Hodgkin lymphomas after allogeneic hematopoietic stem cell transplant.	22136377
Histology	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplant may have a role in the treatment of relapsed/refractory disease or high-risk histologies in the upfront setting.	22136377
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Patients with primary refractory diffuse large B-cell lymphoma (REF DLBCL: progression on or within 3 months of completion of primary therapy) sensitive to salvage chemotherapy undergo autologous stem cell transplant (ASCT).	22136378
Cryptococcus	Stem Cell Exhaustion	Disseminated cryptococcal infection in patient with novel JAK3 mutation severe combined immunodeficiency, with resolution after stem cell transplantation.	22138680
Childhood Non-Hodgkin Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	The aim of this study was to investigate the efficacy of antibiotic prophylaxis in patients undergoing autologous stem cell transplantation (ASCT) for multiple myeloma and non-Hodgkin lymphoma.	22138805
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Human endothelial progenitor cells isolated from COPD patients are dysfunctional.	22139347
Atherosclerosis	Stem Cell Exhaustion	It is accepted that endothelial progenitor cells (EPCs) participate in the repair of dysfunctional endothelium and thus protects against atherosclerosis.	22139347
Multiple Myeloma	Stem Cell Exhaustion	In this study, we evaluated the association between genetic variations in the VEGF gene in patients with multiple myeloma and time to treatment failure (TTF) after high-dose melphalan and stem cell support (HDT), overall survival (OS) and efficacy of the anti-angiogenic drug thalidomide.	22139971
Pancreatic intraepithelial neoplasia	Stem Cell Exhaustion	Targeting of oncogenic Kras to the pancreatic Nestin-expressing embryonic progenitor cells and subsequently to the adult acinar compartment and Nestin-expressing cells is sufficient for the development of low grade pancreatic intraepithelial neoplasia (PanIN) between 2 and 4 months.	22140463
Virus Diseases, Hemorrhagic cystitis	Stem Cell Exhaustion	Prevalence of viral infections and hemorrhagic cystitis in hematopoietic stem cell transplant recipients.	22142049
Hemorrhagic cystitis	Stem Cell Exhaustion	About 7% to 70% of hemorrhagic cystitis is classified as early and late-onset incidence in hematopoietic stem cell transplant patients.	22142049
Infection, Hemorrhagic cystitis	Stem Cell Exhaustion	Detection of single and multiple infections of BK virus, adenovirus, and cytomegalovirus in blood and/or urine samples of hematopoietic stem cell transplant recipients, in combination with 1 or more inducing factors of hemorrhagic cystitis were enforced on the important role these risk factors play in the cause of hemorrhagic cystitis.	22142049
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Although multiple myeloma (MM) remains an incurable disease, considerable improvements in survival have been made with the introduction of autologous stem cell transplantation and new drugs.	22144117
Primary Adrenal Insufficiency	Stem Cell Exhaustion	Primary adrenal insufficiency in a child after busulfan and cyclophosphamide-based conditioning for hematopoietic stem cell transplantation.	22145493
Gonadal Disorders	Stem Cell Exhaustion	High rates of skeletal complications, growth disturbances, thyroid and gonadal dysfunction have been described in children undergoing stem cell transplantation.	22145493
Adrenal cortical hypofunction	Stem Cell Exhaustion	Although secondary adrenal insufficiency has been diagnosed, no primary adrenal insufficiency has been reported after busulfan and cyclophosphamide (Bu/Cy)-based conditioning regimens for stem cell transplantation in children.	22145493
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	A 9-year-old girl with myelodysplastic syndrome was treated with stem cell transplantation of allogeneic origin.	22145493
Chronic graft-versus-host disease	Stem Cell Exhaustion	Then, 17 months after stem cell transplantation, chronic graft-versus-host disease developed and was treated with methyl prednisolone for 3 months.	22145493
Primary Adrenal Insufficiency	Stem Cell Exhaustion	Primary adrenal insufficiency which was observed in our patient after Bu/Cy-based conditioning regimen for stem cell transplantation has not been reported in children and adrenal function should be closely monitored in these patients both before stem cell transplantation and after stem cell transplantation.	22145493
Neoplasms	Stem Cell Exhaustion	The expression of the liver stem cell markers (c-kit, CD90, CD133 and CK19) in the tumor tissue was detected by immunohistochemistry, and the Kaplan-Meier method was used to evaluate survival.	22146626
Neoplasms	Stem Cell Exhaustion	The high expression of liver stem cell markers in the tumor tissue suggests that these tumors may derive from liver stem cells.	22146626
Hematologic Neoplasms	Stem Cell Exhaustion	We conducted a large prospective randomized trial between July 2006 and August 2009 of an art intervention, Open Window (OW), in patients undergoing stem cell transplantation for a hematological malignancy compared with a control group.	22147646
Amyloidosis	Stem Cell Exhaustion	High-dose melphalan and peripheral blood stem cell transplantation for light-chain amyloidosis with cardiac involvement.	22147893
Amyloidosis	Stem Cell Exhaustion	High-dose melphalan (HDM) plus stem cell transplantation is an effective treatment for light-chain amyloidosis (AL), but is associated with high treatment-related mortality in patients with cardiac involvement.	22147893
Graft-vs-Host Disease	Stem Cell Exhaustion	Disparity of minor histocompatibility antigens (mHAs) is known to induce graft-versus-tumor and graft-versus-host disease reactions in stem cell transplantation.	22150369
Thrombotic Microangiopathies	Stem Cell Exhaustion	Third-party mesenchymal stromal cell infusion is associated with a decrease in thrombotic microangiopathy symptoms observed post-hematopoietic stem cell transplantation.	22151234
Tumor necrosis, Pulmonary Dysfunction	Stem Cell Exhaustion	Soluble tumor necrosis factor receptor: enbrel (etanercept) for subacute pulmonary dysfunction following allogeneic stem cell transplantation.	22155140
physiopathological, Lung diseases	Stem Cell Exhaustion	Subacute lung disease, manifested as either obstructive (OLD) or restrictive (RLD) lung dysfunction, is a common complication following allogeneic stem cell transplantation.	22155140
Lung Injury	Stem Cell Exhaustion	These data support the development of expanded clinical trials to study etanercept as a therapeutic agent for subacute lung injury after allogeneic stem cell transplantation.	22155140
Neoplasms	Stem Cell Exhaustion	Disruption of Klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice.	22155367
Lymphoma, Follicular	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) prolongs survival in patients with relapsed follicular lymphoma.	22155507
Osteoarthritis, Knee	Stem Cell Exhaustion	Synovial fluid CD34- CD44+ CD90+ mesenchymal stem cell levels are associated with the severity of primary knee osteoarthritis.	22155731
Osteoarthritis, Knee	Stem Cell Exhaustion	To the best of our knowledge, no reports have directly compared synovial fluid (SF)- and synovial membrane (SM)-derived mesenchymal stem cells (MSCs) from primary knee osteoarthritis patients in terms of MSC proportion, either immediately after isolation or during culture.	22155731
Glioblastoma Multiforme Pathway, Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	We then investigated the MARK4L and MARK4S expression profile in 21 glioma cell lines and 36 tissues of different malignancy grades, glioblastoma-derived cancer stem cells (GBM CSCs) and mouse neural stem cells (NSCs) by real-time PCR, immunoblotting and immunohistochemistry.	22156016
Encephalomyelitis, MS gene	Stem Cell Exhaustion	Catastrophic demyelinating encephalomyelitis after intrathecal and intravenous stem cell transplantation in a patient with multiple sclerosis.	22156784
MS gene	Stem Cell Exhaustion	Stem cell transplantation is an investigational therapy for multiple sclerosis.	22156784
Encephalomyelitis	Stem Cell Exhaustion	The authors describe a case of catastrophic demyelinating encephalomyelitis following stem cell transplantation in a 17-year-old girl.	22156784
MS gene	Stem Cell Exhaustion	Nine months after an initial diagnosis of multiple sclerosis, she underwent stem cell transplantation in Costa Rica.	22156784
Encephalomyelitis, MS gene	Stem Cell Exhaustion	This case demonstrates that stem cell transplantation may provoke life-threatening encephalomyelitis in patients with multiple sclerosis.	22156784
Gastrointestinal mucositis	Stem Cell Exhaustion	Influence of oral health on mucositis in patients undergoing hematopoietic progenitor cell transplantation (HPCT).	22157660
Gastrointestinal mucositis	Stem Cell Exhaustion	To establish whether or not the state of patient oral health can influence the occurrence and/or severity of oral mucositis during hematopoietic progenitor cell transplantation (HPCT).	22157660
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	This new approach will expand our possibilities to separate CML and normal stem cells, present in a single bone marrow or peripheral blood sample, thereby offering opportunities to better identify new CML stem-cell-specific targets.	22157734
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Residual normal stem cells can be detected in newly diagnosed chronic myeloid leukemia patients by a new flow cytometric approach and predict for optimal response to imatinib.	22157734
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Insensitivity of chronic myeloid leukemia (CML) hematopoietic stem cells to tyrosine kinase inhibitors (TKIs) prevents eradication of the disease and may be involved in clinical resistance.	22157734
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	For improved treatment results more knowledge about CML stem cells is needed.	22157734
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We here present a new flow cytometric approach enabling prospective discrimination of CML stem cells from their normal counterparts within single-patient samples.	22157734
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	In 24 of 40 newly diagnosed CML patients residual normal CD34(+)CD38(-) stem cells could be identified by lower CD34 and CD45 expression, lower forward/sideward light scatter and by differences of lineage marker expression (CD7, CD11b and CD56) and of CD90.	22157734
Toxic effect	Stem Cell Exhaustion	Patients with residual non-leukemic stem cells had lower clinical risk scores (Sokal, Euro), lower hematological toxicity of imatinib (IM) and better molecular responses to IM than patients without.	22157734
Secondary to, Myeloma cell	Stem Cell Exhaustion	Secondary MGUS after autologous hematopoietic progenitor cell transplantation in plasma cell myeloma: a matter of undetermined significance.	22158387
Myeloma cell	Stem Cell Exhaustion	Plasma cell myeloma, characterized by clonally aberrant plasma cells that produce abnormal monoclonal Igs, is the most common indication for autologous hematopoietic progenitor cell transplantation (AHPCT) in North America.	22158387
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are hematopoietic stem cell disorders that often progress to chemotherapy-resistant secondary acute myeloid leukemia (sAML).	22158538
Degenerative polyarthritis, Osteoporosis	Stem Cell Exhaustion	Differential responsiveness to 17b-estradiol of mesenchymal stem cells from postmenopausal women between osteoporosis and osteoarthritis.	22159632
Degenerative polyarthritis, Osteoporosis	Stem Cell Exhaustion	Differential osteogenic potential and responsiveness to 17b-estradiol (E2) of mesenchymal stem cells (MSCs) were found between postmenopausal women with osteoporosis (OP) and osteoarthritis (OA).	22159632
Recurrent Primary Malignant Neoplasm, Multiple Myeloma	Stem Cell Exhaustion	What is the benefit of maintenance therapy with lenalidomide or bortezomib after autologous stem cell transplantation in multiple myeloma and what is the risk of developing a secondary primary malignancy?	22160035
Coronary Arteriosclerosis, diabetic	Stem Cell Exhaustion	Coronary arterial disease (CAD) is common in diabetic patients, and endothelial progenitor cells (EPCs) are considered a surrogate marker for CAD, but controversies regarding this issue still remain.	22160247
Multiple Myeloma	Stem Cell Exhaustion	Administration of bortezomib before and after autologous stem cell transplantation improves outcome in multiple myeloma patients with deletion 17p.	22160383
Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	Incremental increase in VEGFR1+ hematopoietic progenitor cells and VEGFR2+ endothelial progenitor cells predicts relapse and lack of tumor response in breast cancer patients.	22160642
Specialty Type - cancer	Stem Cell Exhaustion	Four of 14 studied genes, epidermal growth factor receptor (EGFR), Collagen a-1(I) chain, Mast/stem cell growth factor receptor (KIT) and CD47, exhibited significant differences in gene expression between controls and cancer patients.	22160796
HMOX1 gene, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The stem cell-enriched CD34+/CD38+ and CD34+/CD38- fractions of AML cells were found to express Hsp32 mRNA in excess over normal CD34+ progenitor cells.	22165967
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Finally, we were able to demonstrate that SMA-ZnPP inhibits cytokine-dependent proliferation of CD34+/CD38+ and CD34+/CD38- AML progenitor cells in vitro in all patients as well as leukemiainitiation of AML stem cells in NOD-SCID IL-2Rg(-/-) (NSG) mice in vivo.	22165967
HMOX1 gene, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Together, our data suggest that Hsp32 plays an important role as a survival factor in leukemic stem cells and as a potential new target in AML.	22165967
HMOX1 gene	Stem Cell Exhaustion	The Hsp32 inhibitors SMA-ZnPP and PEG-ZnPP exert major growth-inhibitory effects on D34+/CD38+ and CD34+/CD38- AML progenitor cells.	22165967
Klinefelter Syndrome	Stem Cell Exhaustion	Can pubertal boys with Klinefelter syndrome benefit from spermatogonial stem cell banking?	22166807
Klinefelter Syndrome, Infertility	Stem Cell Exhaustion	Although early development of testes appears normal in boys with Klinefelter syndrome (KS), spermatogonial stem cell (SSC) depletion occurs in mid puberty, leading to infertility.	22166807
Stem cells	Stem Cell Exhaustion	Cryopreservation of SSCs prior to stem cell loss is an option that is currently offered to boys who have to undergo gonadotoxic treatments.	22166807
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Treatment, risk factors, and outcome of adults with relapsed AML after reduced intensity conditioning for allogeneic stem cell transplantation.	22167752
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Because information on management and outcome of AML relapse after allogeneic hematopoietic stem cell transplantation (HSCT) with reduced intensity conditioning (RIC) is scarce, a retrospective registry study was performed by the Acute Leukemia Working Party of EBMT.	22167752
Malignant tumor of colon, Carcinogenesis	Stem Cell Exhaustion	The transcription factor SOX2, which is involved in the induction of pluripotent stem cells and contributes to colorectal carcinogenesis, is associated with a poor prognosis in colon cancer (CC).	22168803
Malignant Neoplasms, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myeloid leukemia (CML) is a malignant clonal disease derived from hematopoietic stem cells.	22169287
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	CML stem cells were thought to be the root which could lead disease development and ultimately rapid change.	22169287
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	However, a stable animal model for studying the characteristics of CML stem cells is currently lacking.	22169287
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	This study was aimed to establish a transplanted human CML nude-mice model to further explore the biological behavior of CML stem cells in vivo, and to enrich CML stem cells in nude mice by series transplantation.	22169287
Bacteremia, Infection	Stem Cell Exhaustion	Patients receiving high-dose chemotherapy with autologous peripheral blood stem cell transplantation (PBSCT) are at high risk of infections, especially bacteraemia.	22169408
Lymphoproliferative Disorders	Stem Cell Exhaustion	Epstein-Barr virus-associated post-transplant lymphoproliferative disorders after allogeneic peripheral blood stem cell transplantation for Hodgkin-like adult T-cell leukemia/lymphoma.	22170229
Hodgkin-Like Adult T-Cell Leukemia/Lymphoma	Stem Cell Exhaustion	A 56-year-old woman with Hodgkin-like adult T-cell leukemia/lymphoma was treated with allogeneic peripheral blood stem cell transplantation on 17 April 2009.	22170229
SERPINB3 wt Allele, Specialty Type - cancer, Malignant Neoplasms, Squamous cell carcinoma	Stem Cell Exhaustion	Although the stem cell markers of original normal tissue have been used to identify cancer stem cells in a variety of cancers, the expression and function of p75NTR have been poorly understood in oral squamous cell carcinoma (OSCC).	22170235
Inflammation	Stem Cell Exhaustion	Regenerative potential of human muscle stem cells in chronic inflammation.	22171690
Inflammation	Stem Cell Exhaustion	Chronic inflammation is a profound systemic modification of the cellular microenvironment which could affect survival, repair and maintenance of muscle stem cells.	22171690
Inflammation, Hepatobiliary Disorder	Stem Cell Exhaustion	TLR4-positive hepatic progenitor cells and interlobular bile ducts were significantly correlated with the stage of liver disease (P<0.001), the grade of inflammation (P<0.001), and the activity of portal/septal myofibroblasts (P<0.001).	22173288
Liver damage	Stem Cell Exhaustion	The present results suggest that TLR4 expression by hepatic progenitor cells and biliary epithelial cells contributes to the progression of liver damage in the course of chronic HCV-related infection.	22173288
Ischemia	Stem Cell Exhaustion	Acute ischaemia or other stressors induce the mobilization of progenitor cells from the BM stem cell niche.	22173911
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Acute myocardial infarction activates progenitor cells and increases Wnt signalling in the bone marrow.	22173911
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Acute myocardial infarction is associated with an increased metabolic activity and increased levels of progenitor cells within days after AMI.	22173911
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In contrast to the other stem cell associated antigens analyzed (CD34, CD96, CD117, and CD133), hMICL was expressed on myeloid blast cells only, revealing hMICL as a diagnostic marker in AML.	22173921
Disorder of eye, Specialty Type - cancer, HIV, Acquired Immunodeficiency Syndrome	Stem Cell Exhaustion	Stem cell therapies are currently being applied to over 50 diseases, including heart, lung, neurodegenerative, and eye disease, cancer, and human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS).	22175514
Prostate carcinoma, Spinal Cord Injuries	Stem Cell Exhaustion	Some high-profile therapies include Dendreon's Provenge for prostate cancer, Geron's first-ever embryonic stem cell trials for spinal cord injury, Fibrocell's laViv cellular therapy for wrinkles, and well-established commercial skin substitutes (Organogenesis' Apligraf and Advanced BioHealing's Dermagraft).	22175514
Neurodegenerative Disorders	Stem Cell Exhaustion	Contemporary stem cell science advances include a focus on techniques for the direct reprogramming of cells from one lineage to another without returning to pluripotency as an intermediary step, improved means of generating and characterizing induced pluripotent cells, and progress in approaches to neurodegenerative disease.	22175514
Toxic effect	Stem Cell Exhaustion	Stem cells are useful not only in cell-replacement therapies, but also in disease modeling, drug discovery, and drug toxicity screening.	22175514
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	The pathological characteristics of glioma stem cell niches.	22178090
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	We demonstrate that both CD133(+) blood vessels and nestin(+) blood vessels have an important role in maintaining the structure of the glioma stem cell niche.	22178090
Neoplasms	Stem Cell Exhaustion	Brain tumor stem cells (BTSC) are predicted to be critical drivers of tumor progression due to their self-renewal capacity and limitless proliferative potential.	22178090
Seizures	Stem Cell Exhaustion	High white blood cell concentration in the peripheral blood stem cell product can induce seizures during infusion of autologous peripheral blood stem cells.	22178402
Seizures	Stem Cell Exhaustion	Seizures as a complication of the infusion of autologous peripheral blood stem cells (PBSC) are rare.	22178402
Liver carcinoma, Liver Dysfunction	Stem Cell Exhaustion	Are autologous bone marrow stem cell transplantation and transcatheter arterial embolization the best choices for patients with hepatocellular carcinoma and hepatic dysfunction?	22179797
Liver carcinoma, Liver Dysfunction, Hollings Cancer Center	Stem Cell Exhaustion	The purpose of this work was to evaluate the effects of autologous bone marrow stem cell transplantation (AMSCT) and transarterial embolization (TAE) in patients with hepatocellular carcinoma (HCC) and hepatic dysfunction.	22179797
Hollings Cancer Center, Neoplasms	Stem Cell Exhaustion	A 58-year-old male with HCC and hepatic function of Child's class C was treated with 8 ml of a lipiodol emulsion by injection into the artery feeding of his tumor, and >10(8) bone marrow stem cells were isolated from 400 ml bone marrow and then injected into the right hepatic artery.	22179797
Central neuroblastoma, niobium	Stem Cell Exhaustion	Little is known on strategies to prevent or to treat relapses occurring after haploidentical stem cell transplantation (haplo-HSCT) performed for the high-risk neuroblastoma (NB).	22180305
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Additionally, an immunological mechanism modified by interferon-a might control chronic myeloid leukemia stem cells.	22180435
Diabetes, Ischemia	Stem Cell Exhaustion	Currently undergoing investigation are adipose stem cell (ASC) therapies for diabetes and critical limb ischemia, among others.	22185824
Graft-vs-Host Disease, Sinusitis	Stem Cell Exhaustion	Immunosuppression is the leading cause of recurrent sinus infections after hematopoietic stem cell transplant (HSCT), with increased incidence of sinusitis in patients with chronic graft versus host disease (GVHD).	22186237
Infection of bloodstream	Stem Cell Exhaustion	Mortality after bloodstream infections in allogeneic haematopoietic stem cell transplant (HSCT) recipients.	22187340
Behavioral Symptoms Index Composite Score (BASC-2), Infection of bloodstream	Stem Cell Exhaustion	Bloodstream infections (BSIs) are frequent after allogeneic haematopoietic stem cell transplantation (HSCT).	22187340
Hematologic Neoplasms	Stem Cell Exhaustion	The records of the Infection Control Committee were reviewed to identify patients with haematological malignancies and stem cell transplantation who had at least 1 BDG (Fungitell kit) measurement during the period January 2008 through April 2011.	22188426
Specialty Type - cancer	Stem Cell Exhaustion	In a Cox regression model, stem cell transplant, radiation, and older age at cancer diagnosis were associated with higher hazard of an endocrine condition.	22188743
Sarcoma - category (morphologic abnormality)	Stem Cell Exhaustion	Radiation, stem cell transplant, and sarcoma diagnosis were associated with growth problems.	22188743
Malignant melanoma - category	Stem Cell Exhaustion	C-Kit (CD117), the receptor for the stem cell factor, a growth factor for melanocyte migration and proliferation, has shown differential immunostaining in various benign and malignant melanocytic lesions.	22193299
Thrombocytosis, Thrombocythemia, Essential	Stem Cell Exhaustion	Essential thrombocythemia (ET) is a clonal stem-cell disorder characterized by persistent thrombocytosis.	22196956
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	An overall increase in the number of AML patients diagnosed nationwide over the last five years indicates a need for additional health care resources including curative and therapy-intense strategies, such as stem cell transplant facilities to optimize outcome.	22198187
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer survivors often relapse due to evolving drug-resistant clones and repopulating tumor stem cells.	22198309
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Our preclinical study demonstrated that terminal cancer patient's lymphocytes can be converted from tolerant bystanders in vivo into effective cytotoxic T-lymphocytes in vitro killing patient's own tumor cells containing drug-resistant clones and tumor stem cells.	22198309
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Lymphodepletion is permissive to the development of spontaneous T-cell responses to the self-antigen PR1 early after allogeneic stem cell transplantation and in patients with acute myeloid leukemia undergoing WT1 peptide vaccination following chemotherapy.	22198310
Adenocarcinoma, Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	Number of circulating endothelial progenitor cells and intratumoral microvessel density in non-small cell lung cancer patients: differences in angiogenic status between adenocarcinoma histologic subtypes.	22198428
Malignant neoplasm of lung, Adenocarcinoma	Stem Cell Exhaustion	This study examined the association between the number of circulating endothelial progenitor cells (EPCs), intratumoral microvessel density (MVD) (both of which may be markers for neovascularization), and lung cancer histological types, particularly adenocarcinoma histological subtypes.	22198428
Multiple Myeloma	Stem Cell Exhaustion	Sequential bortezomib, dexamethasone, and thalidomide maintenance therapy after single autologous peripheral stem cell transplantation in patients with multiple myeloma.	22198542
Multiple Myeloma	Stem Cell Exhaustion	We report feasibility and response results of a phase II study investigating prolonged weekly bortezomib and dexamethasone followed by thalidomide and dexamethasone as maintenance therapy after single autologous stem cell transplantation (ASCT) in patients with multiple myeloma.	22198542
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	We studied the outcome of allogeneic hematopoietic stem cell transplantation after lower-intensity conditioning regimens (reduced-intensity conditioning and nonmyeloablative) in patients with non-Hodgkin lymphoma who relapsed after autologous hematopoietic stem cell transplantation.	22198543
Cerebrovascular accident	Stem Cell Exhaustion	Granulocyte-colony stimulating factor for mobilizing bone marrow stem cells in subacute stroke: the stem cell trial of recovery enhancement after stroke 2 randomized controlled trial.	22198983
Cerebrovascular accident	Stem Cell Exhaustion	Granulocyte-colony stimulating factor (G-CSF) is neuroprotective in experimental stroke and mobilizes CD34(+) peripheral blood stem cells into the circulation.	22198983
Non-Small Cell Lung Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	The cancer stem cell antigens CD133, BCRP1/ABCG2 and CD117/c-KIT are not associated with prognosis in resected early-stage non-small cell lung cancer.	22199321
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	In various tumor entities, expression of cancer stem cell (CSC) antigens has been proven to be prognostically unfavorable.	22199321
Barrett Esophagus	Stem Cell Exhaustion	Little is known about the stem cell organisation of the normal oesophagus or Barrett's metaplastic oesophagus.	22200839
Barrett Esophagus, Squamous cell carcinoma of esophagus	Stem Cell Exhaustion	Using non-pathogenic mitochondrial DNA mutations as clonal markers, the authors reveal the stem cell organisation of the human squamous oesophagus and of Barrett's metaplasia and determine the mechanism of clonal expansion of mutations.	22200839
Barrett Esophagus	Stem Cell Exhaustion	Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor.	22200839
Barrett Esophagus	Stem Cell Exhaustion	In Barrett's metaplasia partially CCO-deficient glands indicate that glands are maintained by multiple stem cells.	22200839
Barrett Esophagus	Stem Cell Exhaustion	Wholly mutated Barrett's metaplasia glands containing all the expected differentiated cell lineages were seen, demonstrating multilineage differentiation from a clonal population of Barrett's metaplasia stem cells.	22200839
Barrett Esophagus	Stem Cell Exhaustion	Barrett's metaplasia glands are clonal units, contain multiple multipotential stem cells and most likely divide by fission.	22200839
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	High density of tryptase-positive mast cells in patients with renal cell carcinoma on hemodialysis: correlation with expression of stem cell factor and protease activated receptor-2.	22204707
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	The aim of this study was to clarify the pathologic roles of 2 phenotypes of mast cells, mast cell tryptase and mast cell chymase, and their correlation with stem cell factor and protease-activated receptor 2 in patients with renal cell carcinoma on hemodialysis.	22204707
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	With the use of ChIP on microarray assays in primary leukemia samples, we report that acute myeloid leukemia (AML) blasts exhibit significant alterations in histone H3 acetylation (H3Ac) levels at > 1000 genomic loci compared with CD34(+) progenitor cells.	22207736
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Importantly, core promoter regions tended to have lower H3Ac levels in AML compared with progenitor cells, which suggested that a large number of genes are epigenetically silenced in AML.	22207736
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSCs) are believed to drive tumor progression, but the relative frequencies of CSCs versus non-stem cancer cells span wide ranges even within tumors arising from the same tissue type.	22208390
Specialty Type - cancer	Stem Cell Exhaustion	Strategies for cancer stem cell elimination: insights from mathematical modeling.	22210402
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	The cancer stem cell (CSC) hypothesis states that only a small fraction of a malignant cell population is responsible for tumor growth and relapse.	22210402
S100A4 protein, human	Stem Cell Exhaustion	Further analysis of the same model has indicated that excessive stem cell proliferation leading to malignant transformation mainly results from altered sensitivity to such micro-environmental signals.	22210402
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Imatinib has revolutionized the treatment for adult CML by eliminating allogeneic stem cell transplantation for almost all patients in chronic phase.	22210880
Blast Phase	Stem Cell Exhaustion	Patients in accelerated or blast crisis or who fail to reach landmarks on TKIs either because of intolerance or resistance should pursue stem cell transplantation.	22210880
Malignant Neoplasms	Stem Cell Exhaustion	Expression of deleted in malignant brain tumours 1 (DMBT1) relates to the proliferation and malignant transformation of hepatic progenitor cells in hepatitis B virus-related liver diseases.	22211283
Inflammation, Endothelium	Stem Cell Exhaustion	Systemic inflammation has been associated with an imbalance between endothelial injury and repair, defined by an increased number of circulating endothelial microparticles (EMPs) and a reduced number of endothelial progenitor cells (EPCs).	22211720
Hepatitis E	Stem Cell Exhaustion	Chronic hepatitis E in hematopoietic stem cell transplant patients in a low-endemic country?	22212560
Hepatitis E	Stem Cell Exhaustion	In addition, hepatitis E virus (HEV) reactivation was reported after hematopoietic stem cell transplantation (HSCT).	22212560
Aortic Valve Stenosis, Cardiovascular Diseases, Atherosclerosis, BDI - Functional Impairment	Stem Cell Exhaustion	Cardiovascular disease has been linked to endothelial progenitor cell (EPC) depletion and functional impairment in atherosclerosis and aortic stenosis.	22214418
Coronary Arteriosclerosis	Stem Cell Exhaustion	Endothelial progenitor cell mobilization and platelet microparticle release are influenced by clopidogrel plasma levels in stable coronary artery disease.	22214900
Progeria	Stem Cell Exhaustion	Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model.	22215083
Progeria	Stem Cell Exhaustion	We tested this using muscle-derived stem/progenitor cells (MDSPCs) in a murine progeria model.	22215083
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	An 8-year-old, human immune virus-negative boy received full human leukocyte antigen-matched related allogenic hematopoietic stem cell transplantation (HSCT) for relapsed acute myeloid leukemia.	22217492
Neurologic Dysfunction, primary infection nos, Hematopoietic Cell Transplant Recipient, Immunocompromised Host	Stem Cell Exhaustion	The HPyV9 seroprevalence of liver transplant recipients and patients with neurological dysfunctions did not differ from that of age-matched controls, but a significantly higher seroprevalence was determined in renal and haematopoietic stem-cell transplant recipients, indicating that certain immunocompromised patient groups may be at a higher risk for primary infection with or for reactivation of HPyV9.	22218677
Anemia, Sickle Cell	Stem Cell Exhaustion	Oocyte cryopreservation in a patient with sickle cell disease prior to hematopoietic stem cell transplantation: first report.	22219083
Anemia, Sickle Cell	Stem Cell Exhaustion	To report the first occurrence of successful ovarian stimulation, oocyte retrieval and oocyte cryopreservation for fertility preservation in an adolescent with severe sickle cell disease scheduled to undergo a hematopoietic stem cell transplant Case report.	22219083
Anemia, Sickle Cell	Stem Cell Exhaustion	A 19 year old female with severe sickle cell disease presented for fertility preservation counseling prior to hematopoietic stem cell transplantation.	22219083
Ovarian hyperstimulation, Anemia, Sickle Cell	Stem Cell Exhaustion	Controlled ovarian hyperstimulation and oocyte banking for fertility preservation is feasible in young women with sickle cell disease requiring hematopoietic stem cell transplant and deserves further investigation.	22219083
Malignant neoplasm of ovary	Stem Cell Exhaustion	The role of aldehyde dehydrogenase 1 (ALDH1) as an ovarian cancer stem cell marker and its clinical significance have rarely been explored.	22222226
Neoplasms, Immunocompromised Host	Stem Cell Exhaustion	Both ALDH1(br) and ALDH1(low) cells repopulated stem cell heterogeneity, formed spheroids, and grew into tumors in immunocompromised mice, although these processes were more efficient in ALDH1(br) cells.	22222226
Malignant neoplasm of ovary	Stem Cell Exhaustion	The results did not support ALDH1 alone as an ovarian cancer stem cell marker, but demonstrated that ALDH1 is associated with CD44 expression, chemoresistance, and poor clinical outcome.	22222226
Malignant neoplasm of ovary	Stem Cell Exhaustion	The use of a combination of ALDH1 with other stem cell markers may help define ovarian cancer stem cells more stringently.	22222226
Malignant neoplasm of ovary	Stem Cell Exhaustion	We used an Aldefluor assay to isolate ALDH1-bright (ALDH1(br)) cells from epithelial ovarian cancer cell lines and characterized the properties of the stem cells.	22222226
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Bone marrow stem cell adherence into old anterior myocardial infarction: a scintigraphic study using Tl-201 and Tc-99m-HMPAO.	22222778
Necrosis	Stem Cell Exhaustion	The precise localization of bone marrow stem cells (SCs) into the necrotic tissue after intracoronary infusion (ICI) may be important for the therapeutic outcome.	22222778
Hematologic Neoplasms, Liver Cirrhosis	Stem Cell Exhaustion	Fourteen patients had a haematologic malignancy, four were transplant recipients (allogeneic haematopoietic stem cells in three, liver in one) and one had hepatic cirrhosis.	22227384
T-lymphocyte deficiency	Stem Cell Exhaustion	T-cell deficiency after allogeneic stem cell transplantation (ASCT) is common and has major impact on clinical outcome.	22227522
Myelodysplastic-Myeloproliferative Diseases	Stem Cell Exhaustion	Although poorer collection efficiencies were observed in the myelodysplastic syndrome/myeloproliferative disorder diagnostic subgroup, our findings confirm that PB CD34(+) cell analysis remains a powerful and irreplaceable tool for predicting hematopoietic progenitor cell apheresis CD34(+) cell yield.	22227589
Multiple Myeloma	Stem Cell Exhaustion	Predictors of prolonged survival after allogeneic hematopoietic stem cell transplantation for multiple myeloma.	22231283
Multiple Myeloma, Specialty Type - cancer, Morular Metaplasia of the Endometrium	Stem Cell Exhaustion	A total of 149 patients with multiple myeloma (MM) who received allogeneic hematopoietic stem cell transplantation (allo-HCT) with myeloablative (MAC; n = 38) or reduced-intensity conditioning (RIC; n = 110) regimens at MD Anderson Cancer Center were evaluated.	22231283
Mucopolysaccharidosis I	Stem Cell Exhaustion	It is also generally assumed that cardiovascular risk is increased in MPS and reduced following hematopoietic stem cell transplantation (HSCT) or enzyme replacement therapy (ERT), but this has never been formally evaluated.	22231383
Malignant tumor of colon, Neoplasms	Stem Cell Exhaustion	Recent studies suggest CD133, a surface protein widely used for isolation of colon cancer stem cells, to be associated with tumor angiogenesis and recurrence.	22231565
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Long-term graft-versus-tumor effect following reduced intensity hematopoietic stem cell transplantation in a child with metastatic renal cell carcinoma.	22231905
Refractory Cytopenia of Childhood	Stem Cell Exhaustion	Although target agents have recently been introduced, allogeneic hematopoietic stem cell transplantation exploiting graft-versus-tumor effect still remains an important treatment option for metastatic RCC.	22231905
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	CD27 signaling on chronic myelogenous leukemia stem cells activates Wnt target genes and promotes disease progression.	22232214
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	In the present study, we investigated the possibility that the TNF receptor family member CD27 is present on leukemia stem cells (LSCs) and mediates effects of the immune system on CML.	22232214
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myelogenous leukemia (CML) results from a chromosomal translocation in hematopoietic stem or early progenitor cells that gives rise to the oncogenic BCR/ABL fusion protein.	22232214
leukemia, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	In a mouse model of CML, BCR/ABL+ LSCs and leukemia progenitor cells were found to express CD27.	22232214
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Furthermore, CD27 was expressed on CML stem/progenitor cells in the bone marrow of CML patients, and CD27 signaling promoted growth of BCR/ABL+ human leukemia cells by activating the Wnt pathway.	22232214
Hemolysis (lab result), Aplastic Anemia	Stem Cell Exhaustion	A case of acute hemolytic transfusion reaction caused by anti-AnWj is reported in a patient with aplastic anemia requiring allogeneic stem cell transplantation.	22233405
Endothelial dysfunction	Stem Cell Exhaustion	Blood endothelial progenitor cells (EPC) and microparticles (EMP) have been proposed as markers of endothelial dysfunction.	22234180
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Azacitidine augments expansion of regulatory T cells after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML).	22234690
Graft-vs-Host Disease	Stem Cell Exhaustion	Strategies that augment a GVL effect without increasing the risk of GVHD are required to improve the outcome after allogeneic stem cell transplantation (SCT).	22234690
Neoplasms	Stem Cell Exhaustion	We find that the number of 5 hmC positive cells and the amount of 5 hmC/dG in the genome that has been proposed to be related to pluripotency and lineage commitment in embryonic stem cells is also associated with brain tumor differentiation and anaplasia.	22234893
Hollings Cancer Center	Stem Cell Exhaustion	As a proof of this concept, a recent study demonstrated a genomic subtype of HCC that expressed CC-like gene expression traits, such as CC-like HCC, which revealed the common genomic trait of stem-cell-like properties and aggressive clinical outcomes.	22234953
Hollings Cancer Center	Stem Cell Exhaustion	This suggests that S-HCC may harbor common intermediate traits between HCC and CC, including stem-cell traits, which are similar to those of CC-like HCC.	22234953
Hollings Cancer Center	Stem Cell Exhaustion	Scirrhous HCC (S-HCC), a rare variant of HCC, is characterized by abundant fibrous stroma and has been known to express several liver stem/progenitor cell markers.	22234953
Squamous cell carcinoma of esophagus	Stem Cell Exhaustion	Prognostic value of the stem cell markers CD133 and ABCG2 expression in esophageal squamous cell carcinoma.	22236447
Extrapulmonary Small Cell Carcinoma, Specialty Type - cancer, Squamous cell carcinoma of esophagus	Stem Cell Exhaustion	In the light of increasing evidence supporting cancer stem cells (CSCs) theory, the expression of two stem cell markers, CD133 and adenosine triphosphate-binding cassette superfamily G member 2 (ABCG2), in esophageal squamous cell carcinoma (ESCC) was investigated, and their prognostic values were evaluated.	22236447
Ocular surface disease, Limbal stem cell deficiency	Stem Cell Exhaustion	Retrospective noncomparative case series of 7 eyes in 7 consecutive patients with ocular surface disease and limbal stem cell deficiency treated with KPro after failed KLAL.	22236785
Childhood Breast Carcinoma	Stem Cell Exhaustion	Breast cancer cells with CD44+CD24-/low gene expression signature have been suggested to have stem cell-like tumor-initiating properties.	22237177
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	In addition, either ALDH1 or SOX2 may be a candidate marker for cancer stem cells in luminal subtype breast cancer.	22237177
Primary Myelofibrosis	Stem Cell Exhaustion	[Stem cell transplantation in myelofibrosis].	22238916
Chronic myeloproliferative disorder, Primary Myelofibrosis	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (ASCT) offers the only potentially curative therapy for myelofibrosis, a malignant myeloproliferative disease.	22238916
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Functional characteristics of mesenchymal stem cells derived from bone marrow of patients with myelodysplastic syndromes.	22240014
Ischemia	Stem Cell Exhaustion	Arterio-venous gradients of endothelial progenitor cells reveal a complex kinetics in human limb ischemia.	22240360
Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	Detection of circulating tumor cells and tumor stem cells in patients with breast cancer by using flow cytometry: a valuable tool for diagnosis and prognosis evaluation.	22241087
Neoplasms	Stem Cell Exhaustion	Circulating tumor stem cells (CTSC), a subpopulation of circulating tumor cells (CTC), may lead to recurrent diseases.	22241087
Angioendotheliomatosis	Stem Cell Exhaustion	[Sustained complete remission of intravascular large B-cell lymphoma with recurrent CNS involvement by autologous peripheral blood stem cell transplantation preconditioned with TBC regimen].	22241155
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) is an effective therapeutic option for refractory or high-risk aggressive lymphoma.	22241155
Infiltration, Acute lymphocytic leukemia	Stem Cell Exhaustion	[Bilateral renal infiltration of acute lymphoblastic leukemia cells at relapse after allogeneic stem cell transplantation].	22241156
Lupus Erythematosus	Stem Cell Exhaustion	[Late results of high-dose immunosuppressive therapy with autotransplantation of hematopoietic stem cells in patients with severe refractory systemic lupus erythematosus].	22242267
Lupus Erythematosus, Encephalitis, St. Louis	Stem Cell Exhaustion	The aim of the study was to assess long-term results of high-dose immunosuppressive therapy with autoimplantation of hemopoietic stem cells in patients with severe systemic lupus erythematosus (SLE) resistant to standard immunosuppressive therapy and compare them with the outcome of the two modalities.	22242267
Lupus Erythematosus	Stem Cell Exhaustion	It is concluded that high-dose immunosuppressive therapy with autoimplantation of hemopoietic stem cells is an efficacious tool for the treatment of lupus erythematosus resistant to standard therapy and has advantages over the latter.	22242267
Specialty Type - cancer, Malignant neoplasm of stomach, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Expression of cancer stem cell markers ALDH1, CD44 and CD133 in primary tumor and lymph node metastasis of gastric cancer.	22243781
Specialty Type - cancer, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Recently, cancer stem cells (CSCs) in tumors were found to possess the ability to sustain tumor self-renewal, initiate tumor progression, and possibly also contribute to cancer metastasis.	22243781
B-Cell Lymphomas	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation in patients with diffuse large B cell lymphoma relapsed after autologous stem cell transplantation: a GITMO study.	22245922
Parainfluenza Virus Infections, leukemia	Stem Cell Exhaustion	The characteristics and outcomes of parainfluenza virus infections in 200 patients with leukemia or recipients of hematopoietic stem cell transplantation.	22246027
leukemia	Stem Cell Exhaustion	Community respiratory viruses are significant causes of morbidity and mortality in patients with leukemia and hematopoietic stem cell transplant (HSCT) recipients.	22246027
PULMONARY VENOOCCLUSIVE DISEASE 1, AUTOSOMAL DOMINANT	Stem Cell Exhaustion	This report is the first to describe PVOD following RIC stem cell transplantation.	22246490
Colorectal Carcinoma, Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	CD133 has been identified as a putative cancer stem cell (CSC) marker in various cancers including colorectal cancer.	22246526
Systemic Scleroderma, Sample Size Calculation	Stem Cell Exhaustion	Autologous stem cell transplantation (aSCT) for systemic sclerosis (SSc) has been shown to be effective in recent reports.	22247352
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Prolonged survival with imatinib mesylate combined with chemotherapy and allogeneic stem cell transplantation in de novo Ph+ acute myeloid leukemia.	22248505
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	A randomised phase II study of the efficacy, safety and cost-effectiveness of pegfilgrastim and filgrastim after autologous stem cell transplant for lymphoma and myeloma (PALM study).	22248711
Febrile Neutropenia, Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	To evaluate in a multicentre randomised study the effect on duration of febrile neutropenia (FN), the safety and cost-effectiveness of a single subcutaneous pegfilgrastim injection compared with daily injections of filgrastim after peripheral blood stem cell transplantation in patients receiving high dose chemotherapy for myeloma and lymphoma.	22248711
Mobilized Peripheral Blood Stem Cell, Multiple Myeloma	Stem Cell Exhaustion	Intermediate-dose versus low-dose cyclophosphamide and granulocyte colony-stimulating factor for peripheral blood stem cell mobilization in patients with multiple myeloma treated with novel induction therapies.	22248715
Multiple Myeloma	Stem Cell Exhaustion	These data caution against the use of LD-CY-containing mobilization strategies in patients with multiple myeloma undergoing stem cell collection after novel induction regimens.	22248715
Multiple Myeloma	Stem Cell Exhaustion	Peripheral blood progenitor cell mobilization with intermediate-dose cyclophosphamide (ID-CY) and granulocyte colony-stimulating factor (G-CSF) has been shown to be more efficacious, albeit more toxic, than low-dose cyclophosphamide (LD-CY) mobilization regimens in patients with multiple myeloma treated with conventional therapies.	22248715
Failure	Stem Cell Exhaustion	In conclusion, compared with LD-CY, ID-CY produced a more robust peripheral blood progenitor cell mobilization and significantly reduced the rates of mobilization failure.	22248715
Toxoplasmosis	Stem Cell Exhaustion	Toxoplasmosis after allogeneic stem cell transplantation--a single centre experience.	22249208
Toxoplasmosis	Stem Cell Exhaustion	Toxoplasmosis is a rare but possibly underestimated complication following allogeneic stem cell transplantation with a high mortality rate.	22249208
Personality Character, PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS), a clonal disorder originating from hematopoietic stem cell, is characterized by a progressive character often leading to transformation to acute myeloid leukemia.	22250017
Specialty Type - cancer, Neoplasms, Carcinogenesis	Stem Cell Exhaustion	Because of some inconsistencies in the traditional model of human colorectal carcinogenesis, the cancer stem cell (CSC) model was recently proposed, in which tumor results from neoplastic transformation of stem cells, which become CSCs.	22250106
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	A randomized study comparing yttrium-90 ibritumomab tiuxetan (Zevalin) and high-dose BEAM chemotherapy versus BEAM alone as the conditioning regimen before autologous stem cell transplantation in patients with aggressive lymphoma.	22252613
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	High-dose chemotherapy combined with autologous stem-cell transplantation (ASCT) is the standard therapy for refractory/relapsed aggressive lymphoma.	22252613
Loneliness	Stem Cell Exhaustion	Social correlates of distress following hematopoietic stem cell transplantation: exploring the role of loneliness and cognitive processing.	22253329
Specialty Type - cancer	Stem Cell Exhaustion	Participants were 195 cancer survivors who had undergone hematopoietic stem cell transplantation.	22253329
Vascular Diseases, Systemic Scleroderma, Sample Size Calculation	Stem Cell Exhaustion	It has been proposed that dysfunctional endothelial progenitor cells (EPCs) play a role in pathogenic vasculopathy in systemic sclerosis (SSc).	22258488
Non-Cancer Related Death, Specialty Type - cancer	Stem Cell Exhaustion	This study provides further evidence for the stem cell character of ALDH1+ cells, here in benign breast tissue of cancer and non-cancer patients throughout non-lactating adult life, and contributes evidence of benign stromal ALDH1+ cells.	22260461
Childhood Breast Carcinoma	Stem Cell Exhaustion	Distribution of aldehyde dehydrogenase 1-positive stem cells in benign mammary tissue from women with and without breast cancer.	22260461
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Relapse of acute myeloid leukemia (AML) is thought to reflect the failure of current therapies to adequately target leukemia stem cells (LSCs), the rare, resistant cells presumed responsible for maintenance of the leukemia and typically enriched in the CD34(+)CD38(-) cell population.	22262762
Diabetes Mellitus	Stem Cell Exhaustion	We tested the hypothesis that new-onset posttransplantation diabetes mellitus (PTDM) is associated with measurable changes in Treg subsets after allogeneic hematopoietic stem cell transplantation (HSCT).	22262764
Neoplasms, Primary malignant neoplasm	Stem Cell Exhaustion	Expression of stem cell and epithelial-mesenchymal transition markers in primary breast cancer patients with circulating tumor cells.	22264265
Neoplasms, Childhood Breast Carcinoma, Primary Neoplasm	Stem Cell Exhaustion	The presence of circulating tumor cells (CTC) in breast cancer might be associated with stem cell-like tumor cells which have been suggested to be the active source of metastatic spread in primary tumors.	22264265
Primary malignant neoplasm	Stem Cell Exhaustion	We studied the expression of three EMT markers and the stem cell marker ALDH1 in CTC from 502 primary breast cancer patients.	22264265
Neoplasms	Stem Cell Exhaustion	The recovered c-DNA was additionally multiplex tested for three EMT markers [TWIST1, Akt2, phosphoinositide kinase-3 (PI3Ka)] and separately for the tumor stem cell marker ALDH1.	22264265
Primary malignant neoplasm	Stem Cell Exhaustion	Our data indicate that (1) a subset of primary breast cancer patients shows EMT and stem cell characteristics and (2) the currently used detection methods for CTC are not efficient to identify a subtype of CTC which underwent EMT.	22264265
Neoplasms	Stem Cell Exhaustion	We previously identified a population of CD133+ brain tumor cells possessing stem cell properties, known as brain tumor initiating cells (BTICs).	22265735
Neoplasms	Stem Cell Exhaustion	Bmi1 expression profiles show a marked elevation in the proneural GBM subtype, and stem cell frequency as assessed by tumor sphere assays correlates with patient outcome.	22265735
Neoplasms, Colorectal Carcinoma, Specialty Type - cancer, Cytogenetic Complete Response	Stem Cell Exhaustion	The clinical significance of circulating tumor cells (CTCs) including cancer stem cells (CSCs) (CTC/CSC) in the tumor drainage vein blood of patients with colorectal cancer (CRC) is unclear.	22267181
Cytomegalovirus Infections	Stem Cell Exhaustion	Failure of pre-emptive treatment of cytomegalovirus infections and antiviral resistance in stem cell transplant recipients.	22267468
Infection	Stem Cell Exhaustion	Treatment of cytomegalovirus (CMV) infections after stem cell transplantation (SCT) does not always lead to a rapid viral response.	22267468
Mantle cell lymphoma	Stem Cell Exhaustion	Consolidative therapy with stem cell transplantation improves survival of patients with mantle cell lymphoma after any induction regimen.	22269117
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Stem Cell Exhaustion	Intensive induction regimen followed by high-dose chemotherapy and autologous stem cell transplantation (auto-SCT) is frequently used to improve outcomes in patients with mantle-cell lymphoma.	22269117
Bone necrosis	Stem Cell Exhaustion	However, there have been no long-term follow-up studies on humans treated with adipose tissue-derived stem cells for osteonecrosis.	22270740
Hip joint pain, Avascular Necrosis of Femur Head	Stem Cell Exhaustion	To determine if treatment with adipose tissue-derived stem cells and platelet-rich plasma leads to the regeneration of medullary bone-like tissue and long-term reduction of hip pain in patients with femoral head osteonecrosis.	22270740
Hip joint pain, Avascular Necrosis of Femur Head	Stem Cell Exhaustion	Two patients (34- and 39-year-old men) with femoral head osteonecrosis and severe hip pain were treated with adipose-derived stem cells.	22270740
Ischemic cardiomyopathy	Stem Cell Exhaustion	Effect of 40 mg versus 10 mg of atorvastatin on oxidized low-density lipoprotein, high-sensitivity C-reactive protein, circulating endothelial-derived microparticles, and endothelial progenitor cells in patients with ischemic cardiomyopathy.	22271072
Ischemic cardiomyopathy, between breakfast and lunch	Stem Cell Exhaustion	There are few recent data to delineate the beyond lipids-decreased effect of statins and the effect of different doses of statins on endothelial-derived microparticles (EMPs) and circulating endothelial progenitor cells (EPCs) in patients with ischemic cardiomyopathy (ICM).	22271072
Hodgkin Disease	Stem Cell Exhaustion	Positron emission tomography response at the time of autologous stem cell transplantation predicts outcome of patients with relapsed and/or refractory Hodgkin's lymphoma responding to prior salvage therapy.	22271893
Hodgkin Disease	Stem Cell Exhaustion	High-dose chemotherapy followed by autologous stem cell transplantation is the standard treatment for relapsed and/or refractory Hodgkin's lymphoma although half of patients relapse after transplantation.	22271893
Hodgkin Disease	Stem Cell Exhaustion	The aim of this study was to confirm the predictive value of positron emission tomography status after salvage therapy and to compare single versus tandem autologous stem cell transplantation in patients with relapsed and/or refractory Hodgkin's lymphoma.	22271893
Hodgkin Disease	Stem Cell Exhaustion	We report a series of 111 consecutive patients with treatment-sensitive relapsed and/or treatment-refractory Hodgkin's lymphoma who achieved complete (positron emission tomography-negative group) or partial remission (positron emission tomography-positive group) at positron emission tomography evaluation after salvage chemotherapy and who underwent single or tandem autologous stem cell transplantation.	22271893
Hodgkin Disease	Stem Cell Exhaustion	In patients with relapsed/refractory Hodgkin's lymphoma responding to prior salvage therapy, positron emission tomography response at time of autologous stem cell transplantation favorably influences outcome and enables identification of patients requiring single or tandem transplantation.	22271893
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	In this validation study, we refined the standard operating procedure (SOP) for flow cytometry characterisation and functional analysis of CPCs from the first 18 patients of the Progenitor Cell Response after Myocardial Infarction Study (ProMIS).	22272341
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Stepwise optimization of the procedure for assessment of circulating progenitor cells in patients with myocardial infarction.	22272341
diabetic	Stem Cell Exhaustion	The number and functional activity of circulating progenitor cells (CPCs) is altered in diabetic patients.	22272341
Pneumocystis jiroveci pneumonia	Stem Cell Exhaustion	Pneumocystis jirovecii pneumonia (PJP) was found in four patients (3%, 4/122) receiving alemtuzumab as conditioning for stem cell transplant or salvage treatment.	22273250
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In this report, we describe the experience of a 53-year-old woman who is the sole caregiver for her husband, who has acute myelogenous leukemia and was undergoing allogeneic hematopoietic stem cell transplantation.	22274687
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Senescent cells in growing tumors: population dynamics and cancer stem cells.	22275856
Specialty Type - cancer	Stem Cell Exhaustion	In the hierarchical cancer model a subset of the cells, the cancer stem cells, divide indefinitely while other cells eventually turn senescent.	22275856
Specialty Type - cancer	Stem Cell Exhaustion	We conclude that enhancing senescence is unlikely to provide a useful therapeutic strategy to fight cancer, unless the cancer stem cells are specifically targeted.	22275856
Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	High expression of CD133 and b-catenin, both related to cancer stem cell phenotypes, might be predictive markers for metastasis.	22276605
Cerebral Infarction	Stem Cell Exhaustion	Neuronal stem cells are mobilized after cerebral infarction.	22277485
Cerebrovascular accident	Stem Cell Exhaustion	We had shown that appropriate support of these stem cells, achieved by therapeutic angiogenesis, enhances neurological recovery in experimental stroke model.	22277485
Neurologic Symptoms, Amyloidosis	Stem Cell Exhaustion	High-dose melphalan with stem cell transplantation improves prognosis of systemic AL amyloidosis including neurological symptoms.	22277508
Alzheimers Disease	Stem Cell Exhaustion	Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells.	22278060
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	Age determines the prognostic role of the cancer stem cell marker aldehyde dehydrogenase-1 in breast cancer.	22280212
Childhood Breast Carcinoma	Stem Cell Exhaustion	The purpose of this study was to compare the expression and the prognostic effect of the breast cancer stem cell marker aldehyde dehydrogenase-1 (ALDH1) in young and elderly breast cancer patients.	22280212
Primary Myelofibrosis	Stem Cell Exhaustion	To define a prognostic model for predicting outcome of reduced-intensity allogeneic stem cell transplantation (RIC-ASCT) for myelofibrosis we evaluated 150 homogeneously treated patients and developed a new risk score for overall survival (OS).	22280409
Idiopathic Pulmonary Fibrosis	Stem Cell Exhaustion	Because most fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF), are associated with vascular remodeling, and as endothelial progenitor cells (EPCs) may be involved in this process, we investigated the impact of TGF-b1 modulation of EPC angiogenic properties.	22284809
Ischemia, Diabetic Foot, Ulcer	Stem Cell Exhaustion	Autologous stem cell therapy in the treatment of limb ischaemia induced chronic tissue ulcers of diabetic foot patients.	22284892
Autoimmune hemolytic anemia	Stem Cell Exhaustion	Livedo reticularis associated with autoimmune hemolytic anemia: prolonged remission induced by peripheral blood stem cell transplantation relapse after 10 years and restoration of hemoglobin levels by rituximab.	22286652
Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	It is described and discussed a case of livedo reticularis associated with AIHA treated with peripheral blood stem cell transplantation (PBSCT) that went into full remission for 10 years.	22286652
vasculogenesis	Stem Cell Exhaustion	Neovasculogenesis induced by stem cell therapy could be a useful approach for these patients.	22289660
melanoma, Specialty Type - cancer	Stem Cell Exhaustion	Regression of metastatic melanoma in a patient by antibody targeting of cancer stem cells.	22289880
Acute lymphocytic leukemia	Stem Cell Exhaustion	Safety and efficacy of total body irradiation, cyclophosphamide, and cytarabine as a conditioning regimen for allogeneic hematopoietic stem cell transplantation in patients with acute lymphoblastic leukemia.	22290459
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	Disease relapse still greatly interferes with the success of allogeneic hematopoietic stem cell transplantation (HSCT) for acute lymphoblastic leukemia (ALL).	22290459
Diabetes Mellitus	Stem Cell Exhaustion	The possible role of ribosomal protein S6 kinase 4 in the senescence of endothelial progenitor cells in diabetes mellitus.	22297070
Hyperglycemia, Dominica, Diabetes Mellitus	Stem Cell Exhaustion	The decrease and dysfunction of endothelial progenitor cells (EPCs) has been assumed as an important cause/consequence of diabetes mellitus (DM) and its complications, in which the senescence of EPCs induced by hyperglycemia may play an immensurable role.	22297070
Coronary Arteriosclerosis	Stem Cell Exhaustion	Endothelial progenitor cells are associated with plasma homocysteine in coronary artery disease.	22299389
Coronary Arteriosclerosis	Stem Cell Exhaustion	Little is known about the association between plasma homocysteine (Hcy) and endothelial progenitor cells (EPCs) in coronary artery disease (CAD).	22299389
Blastic plasmacytoid dendritic cell neoplasm, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We report a 15-year-old boy with blastic plasmacytoid dendritic cell neoplasm who was treated with acute myeloid leukemia-based polychemotherapy and subsequent allogenic stem cell transplantation.	22300352
PMF Regimen	Stem Cell Exhaustion	In this study we evaluated the apoptosis-related gene and protein expression of BCL2 family members in bone marrow CD34+ hematopoietic stem cells (HSC) and peripheral blood leukocytes from ET and PMF patients.	22300941
Neoplasms	Stem Cell Exhaustion	Expression of the stem cell marker octamer 4 (Oct-4) in various neoplasms has been previously reported, but very little is currently known about the potential function of Oct-4 in this setting.	22300949
Multiple Myeloma	Stem Cell Exhaustion	Bioactivity and prognostic significance of growth differentiation factor GDF15 secreted by bone marrow mesenchymal stem cells in multiple myeloma.	22301101
Multiple Myeloma	Stem Cell Exhaustion	Overexpression of growth differentiation factor 15 (GDF15) by bone marrow mesenchymal stem cells occurs widely in patients with multiple myeloma, but the pathophysiologic effects of GDF15 in this setting remain undefined.	22301101
Olivopontocerebellar Atrophies	Stem Cell Exhaustion	Generation of induced pluripotent stem cells from skin fibroblasts of a patient with olivopontocerebellar atrophy.	22301348
Axonal neuropathy	Stem Cell Exhaustion	Application of autologous bone marrow stem cells in giant axonal neuropathy.	22301809
Hematologic Neoplasms	Stem Cell Exhaustion	Prognostic factors in patients aged 50 years or older undergoing allogeneic hematopoietic stem cell transplantation for hematologic malignancy.	22302471
Hematologic Neoplasms	Stem Cell Exhaustion	We retrospectively analyzed patients aged C 50 years with hematologic malignancies who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) to identify preoperative variables predicting the outcome.	22302471
Fibrosis Assessment	Stem Cell Exhaustion	Activin-A is a molecule of the TGF superfamily, implicated in liver fibrosis, regeneration and stem cell differentiation.	22304651
Bronchiolitis Obliterans	Stem Cell Exhaustion	Altered progenitor cell and cytokine profiles in bronchiolitis obliterans syndrome.	22305385
Lung Injury, Fibrosis Assessment	Stem Cell Exhaustion	The contribution of CD45(+)collagen-1(+) fibrocytes to fibrosis has been documented elsewhere and recently identified epithelial-like progenitor cells marked by Clara cell secretory protein (CCSP(+)) may be protective after lung injury.	22305385
Childhood Breast Carcinoma	Stem Cell Exhaustion	Long-term survival after high-dose chemotherapy followed by peripheral stem cell rescue for high-risk, locally advanced/inflammatory, and metastatic breast cancer.	22306735
Degenerative disorder	Stem Cell Exhaustion	The generation of induced pluripotent stem cells (iPSCs) from differentiated somatic cells by over-expression of several transcription factors has the potential to cure many genetic and degenerative diseases currently recalcitrant to traditional clinical approaches.	22310243
Malignant Neoplasms	Stem Cell Exhaustion	Dose-adjusted EPOCH-rituximab combined with fludarabine provides an effective bridge to reduced-intensity allogeneic hematopoietic stem-cell transplantation in patients with lymphoid malignancies.	22312100
Malignant Neoplasms	Stem Cell Exhaustion	There is currently no standard chemotherapy regimen for patients with lymphoid malignancies being considered for reduced-intensity conditioning allogeneic hematopoietic stem-cell transplantation (RIC-alloHSCT).	22312100
Degenerative polyarthritis	Stem Cell Exhaustion	Direct transplantation of mesenchymal stem cells into the knee joints of Hartley strain guinea pigs with spontaneous osteoarthritis.	22314040
Degenerative polyarthritis	Stem Cell Exhaustion	The aim of this study was to test the outcome of intra-articular transplantation of mesenchymal stem cells suspended in hyaluronic acid (HA) in the knee joints of Hartley strain guinea pigs with spontaneous osteoarthritis (OA).	22314040
Neoplasms, Carcinoma	Stem Cell Exhaustion	In the present study we have investigated the morphologic features, the CpG methylator phenotype (CIMP), microsatellite instability (MSI), and the immunohistochemical profile, including the expression of transcription factors (TTF1, ASH1, CDX2, and PAX5), stem cell markers (CD117 and CD34), and cytokeratins 7 and 20, in a series of 39 carcinomas (27 NECs and 12 MANECs) to better characterize such neoplasms and to search for prognostic indicators.	22314183
Neoplasms	Stem Cell Exhaustion	In addition to these prognostic features, neoplasms showed different expression of transcription factors, stem cell markers, and cytokeratins that should be considered for diagnostic purposes and, especially, for discriminating among possible differential diagnoses.	22314183
Paroxysmal nocturnal hemoglobinuria, Glycosylphosphatidylinositols	Stem Cell Exhaustion	Patients with paroxysmal nocturnal hemoglobinuria harbor clonal glycosylphosphatidylinositol-anchor deficient cells arising from a multipotent hematopoietic stem cell acquiring a PIG-A mutation.	22315493
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cells.	22315493
Paroxysmal nocturnal hemoglobinuria, Aplastic Anemia, MYELODYSPLASTIC SYNDROME, Glycosylphosphatidylinositols	Stem Cell Exhaustion	In contrast to aplastic anemia and paroxysmal nocturnal hemoglobinuria, where PIG-A mutations arise from multipotent hematopoietic stem cells, glycosylphosphatidylinositol-anchor deficient cells in myelodysplastic syndromes appear to arise from more committed progenitors.	22315493
Aplastic Anemia, MYELODYSPLASTIC SYNDROME, Glycosylphosphatidylinositols	Stem Cell Exhaustion	We used peripheral blood flow cytometry to identify glycosylphosphatidylinositol-anchor deficient blood cells, a proaerolysin-resistant colony forming cell assay to select glycosylphosphatidylinositol-anchor deficient progenitor cells, a novel T-lymphocyte enrichment culture assay with proaerolysin selection to expand glycosylphosphatidylinositol-anchor deficient T lymphocytes, and PIG-A gene sequencing assays to identify and analyze PIG-A mutations in patients with aplastic anemia and myelodysplastic syndromes.	22315493
Aplastic Anemia	Stem Cell Exhaustion	Bone marrow versus peripheral blood as the stem cell source for sibling transplants in acquired aplastic anemia: survival advantage for bone marrow in all age groups.	22315497
Acquired aplastic anemia	Stem Cell Exhaustion	Bone marrow has been shown to be superior to peripheral blood, as a stem cell source, in young patients (<20 years of age) with acquired aplastic anemia undergoing a matched sibling transplant.	22315497
Aplastic Anemia	Stem Cell Exhaustion	This study shows that bone marrow should be the preferred stem cell source for matched sibling transplants in acquired aplastic anemia, in patients of all age groups.	22315497
Acquired aplastic anemia	Stem Cell Exhaustion	We analyzed 1886 patients with acquired aplastic anemia who received a first transplant from a human leukocyte antigen identical sibling between 1999 and 2009, with either bone marrow (n=1163) or peripheral blood (n=723) as the source of stem cells.	22315497
Drug-Induced Liver Disease	Stem Cell Exhaustion	The study discusses the putative contribution of circulating progenitor cells activated by 5-HT(2B) receptor agonists in the development of drug-induced heart disease.	22320434
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Allogeneic stem cell transplant for multiple myeloma (MM) is one treatment associated with long-term disease-free survival.	22327126
Specialty Type - cancer	Stem Cell Exhaustion	Cultured in vitro, these ascitic cells displayed the potential for self-renewal and long-term proliferation, and expressed the typical cancer stem/progenitor cell markers CD44(high), CD24(low), and AC133(+).	22330345
Carcinoma, Ovarian Epithelial, Ascites	Stem Cell Exhaustion	Isolation and characterization of stromal progenitor cells from ascites of patients with epithelial ovarian adenocarcinoma.	22330345
Carcinoma, Ovarian Epithelial, Ascites	Stem Cell Exhaustion	This study aimed to isolate and characterize stromal progenitor cells from the ascites of patients with epithelial ovarian adenocarcinoma (EOA).	22330345
Malignant neoplasm of ovary	Stem Cell Exhaustion	The established culture system provides an in vitro model for the selection of drugs that target cancer-associated stromal progenitor cells, and for the development of ovarian cancer treatments.	22330345
CLU protein, human, Ischemia	Stem Cell Exhaustion	Trials have reported clinical improvement and reduced need for amputation in critical limb ischemia (CLI) patients receiving therapeutic angiogenesis with stem cells.	22330628
Amyloidosis	Stem Cell Exhaustion	We developed a prognostic model based on 810 patients with newly diagnosed AL amyloidosis, which was further examined in two other datasets: 303 patients undergoing stem-cell transplantation, and 103 patients enrolled onto different clinical trials.	22331953
Specialty Type - cancer, Squamous cell carcinoma of the head and neck	Stem Cell Exhaustion	Cancer stem cell phenotype relates to radio-chemotherapy outcome in locally advanced squamous cell head-neck cancer.	22333601
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSCs) tend to repopulate malignant tumours during radiotherapy and, therefore, prolongation of the overall treatment time may result in radiotherapy failure.	22333601
Graft-vs-Host Disease	Stem Cell Exhaustion	[Risk factors of graft-versus-host disease in patients after allogeneic stem cell transplantation].	22335138
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GVHD) is the most common and most serious complication of allogeneic hematopoetic stem cell transplantation (HSCT).	22335138
Acute GVH disease	Stem Cell Exhaustion	The purpose of this study was to evaluate the influence of different factors, such as stem cell source, type of donor, conditioning regimen and acute graft-versus-host disease, on early lymphocyte recovery after transplantation.	22337266
Nasal sinus, Communicable Diseases	Stem Cell Exhaustion	Intercurrent infectious diseases in post-stem cell transplant patients: paranasal sinusitis.	22337395
Cytomegalovirus	Stem Cell Exhaustion	[Cytomegalovirus enteritis after allogeneic hematopoietic stem cell transplantation].	22338172
Enteritis	Stem Cell Exhaustion	To analyse the clinical features, diagnostic methods and risk factors of cytomegalovirus (CMV) enteritis after allogeneic hematopoietic stem cell transplantation (allo-HSCT).	22338172
FGR gene	Stem Cell Exhaustion	The aim of our study was to investigate the change of count and the status of cellular senescence in fetal endothelial progenitor cells (EPCs) obtained from the umbilical cord blood of women with fetal growth restriction (FGR).	22339619
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	The rituximab combined with chemotherapy can significantly improve the therapeutic effect of the DLBCL, and hematopoietic stem cell transplantation is the best choice for treating patients with DLBCL.	22339956
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Autologous bone marrow stem cell transplantation for the treatment of type 2 diabetes mellitus.	22340214
Diabetes Mellitus, Insulin-Dependent, Dominica	Stem Cell Exhaustion	Autologous peripheral stem cell transplantation was first reported in 2007 to treat type 1 diabetes mellitus (DM) and achieved encouraging effect, but whether similar outcome can be achieved in type 2 DM is not well demonstrated.	22340214
Neoplasms, Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	A preliminary investigation of the relationship between circulating tumor cells and cancer stem cells in patients with breast cancer.	22340707
Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	In this study, we explored the relationship between the circulating tumor cells (CTC) and the CTC-cancer stem cells (CSC) in the patients with breast cancer.	22340707
Diabetes, Homeobox Protein Hox-B4	Stem Cell Exhaustion	Diabetes down-regulated IGF-1, IGFBP-5, VEGF, SDF-1, IL-6, IL-1a and TNF-a expression and affected the expression of Bmi-1, Gfi1, Tel and Hox-B4 which could prevent premature senescence and maintain the self-renewal capacity of stem cells.	22341692
Rheumatoid Arthritis	Stem Cell Exhaustion	Dampened ERK signaling in hematopoietic progenitor cells in rheumatoid arthritis.	22342385
Rheumatoid Arthritis	Stem Cell Exhaustion	In rheumatoid arthritis (RA), hematopoietic progenitor cells (HPC) have age-inappropriate telomeric shortening suggesting premature senescence and possible restriction of proliferative capacity.	22342385
Cerebral Infarction	Stem Cell Exhaustion	Mesenchymal stem cells (MSC) from bone marrow induce neuroprotective effects and improve clinical symptoms in animal models for acute cerebral ischemia.	22342911
Hyperemia	Stem Cell Exhaustion	Relationship among endothelial response to hyperemia, bone marrow-derived progenitor cells, and parathyroid hormone in renal transplantation.	22343335
Hyperemia	Stem Cell Exhaustion	We evaluated the relationship between endothelial response to hyperemia and circulating progenitor cells (CPCs) and endothelial progenitor cells (EPCs) PTH, and genetic parameters in RTRs.	22343335
Mucopolysaccharidoses	Stem Cell Exhaustion	We assume that technical improvements such as standardised use of the laryngeal mask airway or attached tube channel videolaryngoscopes as well as a stem cell transplantation treatment of the disease helped the management of older children with mucopolysaccharidosis 1.	22343608
Hematological Disease	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) has been widely used for treating oncological and hematological diseases.	22344354
Specialty Type - cancer	Stem Cell Exhaustion	The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in women's cancer.	22346766
Invasive Malignant Neoplasm, Neoplasms	Stem Cell Exhaustion	We demonstrate that hypermethylation at stem cell PolyComb Group Target genes (PCGTs) occurs in cytologically normal cells three years in advance of the first morphological neoplastic changes, while hypomethylation occurs preferentially at CpGs which are heavily Methylated in Embryonic Stem Cells (MESCs) and increases significantly with cancer invasion in both the epithelial and stromal tumour compartments.	22346766
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	These findings have major implications for cancer and embryonic stem cell biology and establish the importance of systemic DNA hypomethylation for predicting prognosis in a wide range of different cancers.	22346766
Malignant Neoplasms	Stem Cell Exhaustion	[The incidence of malignancies and surveillance of hematopoietic stem cells donors--the results of the Haemato-Oncology Department University Hospital in Plzen (Pilsen) and Czech National Marrow Donors Registry observation].	22348219
Hematologic Neoplasms, filgrastim	Stem Cell Exhaustion	Granulopoesis colony-stimulating factor filgrastim is used to mobilize peripheral stem cells but there are concerns regarding an elevated risk of haematological malignancies.	22348219
Malignant Neoplasms	Stem Cell Exhaustion	We analyzed the incidence of malignancies and the system of haematopoietic stem cells donor surveillance.	22348219
Colorectal Carcinoma, Childhood Non-Hodgkin Lymphoma, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukaemia, non-Hodgkin lymphoma, renal and colorectal carcinoma were observed in a group of 84 peripheral stem cells sibling donors, providing 337 person-years observation.	22348219
Malignant Neoplasms	Stem Cell Exhaustion	The development of malignancies in hematopoietic stem cells donors can naturally be expected.	22348219
Choroidal Detachment, Cord blood stem cell, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Bilateral choroidal detachment after cord blood stem cell transplantation in an adult patient with acute myeloid leukemia.	22350079
Choroidal Detachment	Stem Cell Exhaustion	We report on bilateral choroidal detachment after a cord blood stem cell transplantation procedure.	22350079
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Decrease in circulating endothelial progenitor cells in treated glioma patients.	22350374
Glioma	Stem Cell Exhaustion	The role of endothelial progenitor cells (EPCs) in the neoangiogenesis of gliomas and the effects of post-surgical therapies (i.e., radiotherapy (RT) and chemotherapy) have not yet been fully elucidated.	22350374
HIV-1 Infection Pathway	Stem Cell Exhaustion	We investigated 503 peripheral blood mononuclear cell (PBMC) samples from 240 patients with iatrogenic immune suppression (71 haematopoietic stem cell recipients, 132 solid organ transplant recipients, 37 others) and 311 PBMC samples from 302 patients with HIV-1 infection for the presence of proviral XMRV by real-time polymerase chain reaction (PCR).	22350961
Liver carcinoma, Hollings Cancer Center, Malignant Neoplasms	Stem Cell Exhaustion	The Wnt pathway is a key regulator of embryonic development and stem cells, and its aberrant activation is associated with human malignancies, most notably hepatocellular carcinoma (HCC).	22351518
Multiple Myeloma	Stem Cell Exhaustion	[Induction therapy and the role of stem cell transplantation in the treatment of myeloma multiplex in patients aged below 65 years].	22352191
Treatment related secondary malignancy, Thrombocytopenia	Stem Cell Exhaustion	Haematopoietic stem cell transplantation (HSCT) is a situation in which the haemostatic capacity is challenged by severe thrombocytopaenia, chemotherapy-associated mucosal barrier breakdown and the need for invasive procedures.	22356103
Specialty Type - cancer	Stem Cell Exhaustion	The cancer stem cell (CSC) hypothesis has been proposed to reconcile this heterogeneity.	22357206
Rett Syndrome	Stem Cell Exhaustion	To gain further insight into the role of MECP2 in human neurogenesis, we compared the neural differentiation process in mesenchymal stem cells (MSCs) obtained from a RTT patient and from healthy donors.	22357617
Cessation of life	Stem Cell Exhaustion	Incorporating data on age-dependent death of spermatogonial stem cells explains the results from all age groups.	22359510
Non-alcoholic Fatty Liver Disease	Stem Cell Exhaustion	Decreased circulating endothelial progenitor cell levels and function in patients with nonalcoholic fatty liver disease.	22359630
Non-alcoholic Fatty Liver Disease	Stem Cell Exhaustion	Here, we tested the hypothesis that patients with nonalcoholic fatty liver disease (NAFLD) might have decreased endothelial progenitor cell (EPC) levels and attenuated EPC function.	22359630
Immediate hypersensitivity	Stem Cell Exhaustion	Transfer of IgE-mediated hypersensitivity with autologous stem cell transplantation.	22360138
IgE-mediated food allergy	Stem Cell Exhaustion	In this paper, the transfer of IgE-mediated food allergy by means of autologous stem cell transplantation in a 24-years old male patient is reported.	22360138
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	Increase in circulating endothelial progenitor cells predicts response in patients with advanced non-small-cell lung cancer.	22360644
Erectile dysfunction, Peripheral Arterial Diseases	Stem Cell Exhaustion	Arterial erectile dysfunction and peripheral arterial disease: reliability of a new phenotype of endothelial progenitor cells and endothelial microparticles.	22362078
Erectile dysfunction	Stem Cell Exhaustion	The aim of this study was to evaluate whether the blood concentrations of a new immunophenotype of circulating late endothelial progenitor cells (EPC) and endothelial microparticles (EMP) varies in patients with arterial erectile dysfunction (aED) and abnormalities in other arterial districts.	22362078
bone marrow fibrosis, Primary Myelofibrosis, Malignant Neoplasms	Stem Cell Exhaustion	Myelofibrosis (MF) is a life-threatening clonal stem cell malignancy characterized by progressive bone marrow fibrosis and ineffective hematopoiesis.	22362131
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Treatment with 3-6 cycles of PS-341/bortezomib, adriamycin, and dexamethasone (PAD) has been explored in terms of induction therapy prior to autologous stem cell transplantation (ASCT) in patients with multiple myeloma (MM).	22364526
Osteoporosis, Postmenopausal, Calcified (qualifier)	Stem Cell Exhaustion	Association between circulating osteoblast progenitor cells and aortic calcifications in women with postmenopausal osteoporosis.	22366195
Malignant tumor of colon, Neoplasms	Stem Cell Exhaustion	Interleukin-12 inhibits the survival of human colon cancer stem cells in vitro and their tumor initiating capacity in mice.	22366581
Specialty Type - cancer	Stem Cell Exhaustion	Interleukin-12 (IL-12) is a potent immunomodulatory cytokine with unknown direct effect on the property of cancer stem cells (CSCs).	22366581
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	Cancer stem cell marker Bmi-1 expression is associated with basal-like phenotype and poor survival in breast cancer.	22366984
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	The purpose of present study was to examine the expression of cancer stem cell marker Bmi-1 in breast cancer tissue and to evaluate the clinical implication of Bmi-1 expression for these patients.	22366984
Specialty Type - cancer	Stem Cell Exhaustion	Prognostic value of circulating VEGFR2+ bone marrow-derived progenitor cells in patients with advanced cancer.	22370181
Aggressive behavior, Specialty Type - cancer	Stem Cell Exhaustion	We hypothesised that host-related markers, possibly reflecting tumour aggressiveness, such as circulating endothelial cells (CEC) and circulating VEGFR2(+) bone marrow-derived (BMD) progenitor cells, could have prognostic value in patients with advanced cancer enrolled in early anticancer drug development trials.	22370181
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic graft-versus-host disease (cGVHD) is a major complication after allogeneic stem cell transplantation with an adverse effect on both mortality and morbidity.	22371184
Acute GVH disease	Stem Cell Exhaustion	Graft invariant natural killer T-cell dose predicts risk of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation.	22371885
Graft-vs-Host Disease	Stem Cell Exhaustion	We studied whether peripheral blood stem cell (PBSC) graft iNKT-cell dose affects on the occurrence of clinically significant grade II-IV aGVHD in patients (n = 57) undergoing sibling, HLA-identical allogeneic HSCT.	22371885
HIV Infections, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	[Allogeneic stem cell transplantation for acute myeloid leukemia and HIV infection--case 3/2012].	22374660
Allogeneic Hematopoietic Stem Cell Transplantation, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 27-year-old male patient with a past medical history of HIV presented with acute myeloid leukemia for allogeneic hematopoietic stem cell transplantation (HSCT).	22374660
Lupus Erythematosus	Stem Cell Exhaustion	Enhanced apoptosis and senescence of bone-marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus.	22375903
Lupus Erythematosus, Systemic, Encephalitis, St. Louis	Stem Cell Exhaustion	Previous studies indicated that bone marrow mesenchymal stem cells (BMSCs) from patients with systemic lupus erythematosus (SLE) exhibited impaired capacities of proliferation, differentiation, secretion of cytokines, and immune modulation.	22375903
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Retrospective analysis of an efficient peripheral blood stem cell collection and the relation between infused cell dose and clinical outcome in patients with malignant lymphoma and multiple myeloma.	22376221
Lymphoma	Stem Cell Exhaustion	Etoposide (VP16) is a drug used not only for the treatment of lymphoma but also for the collection of peripheral blood stem cells (PBSCs).	22376221
Hematologic Neoplasms, Neoplasms	Stem Cell Exhaustion	In patients with hematologic malignancies who receive stem-cell transplantation, donors' T cells can recognize minor histocompatibility antigens on recipient cells and generate an objective response against the tumor.	22377792
Specialty Type - cancer	Stem Cell Exhaustion	Recent studies found that the stem cell-related genes Sox2, Oct4 and Klf4 are among the target genes regulated by microRNA-145 (miR-145), suggesting that miR-145 possibly plays a role in the maintenance of cancer stem cells.	22378186
Specialty Type - cancer	Stem Cell Exhaustion	Collectively, our data indicate that miR-145 plays an important role in cancer stem cell tumorigenicity, potentially via modulation of the downstream target, Oct4.	22378186
Specialty Type - cancer, Transcription Initiation	Stem Cell Exhaustion	Therefore, it is important to address the involvement of miR-145 in the key roles of cancer stem cells in cancer initiation, progression and reoccurrence.	22378186
Specialty Type - cancer	Stem Cell Exhaustion	To address the role of miR-145 in cancer stem cells, miR-145 was restored in T3A-A3 cells.	22378186
Bone Diseases, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are clonal stem cell diseases of the bone marrow characterized by abnormalities in maturation of hematopoietic cells of all lineages.	22381680
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is a hematopoietic stem cell disorder.	22382018
Cessation of life, leukemia, Acute Promyelocytic Leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The potential clinical impact of data from population-based studies is exemplified with analyses from the Swedish Acute Leukemia Registry containing more than 3300 acute myeloid leukemia (AML) patients diagnosed between 1997 and 2006 with a median follow-up of 6.2 years on (1) the role of intensive combination chemotherapy for older patients with AML, (2) the impact of allogeneic stem cell transplantation on survival of younger patients with AML, and (3) the continuing problem with early deaths in acute promyelocytic leukemia.	22383796
Multiple Myeloma	Stem Cell Exhaustion	Comparable outcomes between unrelated and related donors after reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation in patients with high-risk multiple myeloma.	22385049
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The purpose of this study was to assess the results of allogeneic stem cell transplantation (allo-SCT) after reduced-intensity conditioning (RIC) from matched related donors (MRD) and unrelated donors (URD) in 40 patients with high-risk multiple myeloma (MM) in a single centre.	22385049
Hematologic Neoplasms	Stem Cell Exhaustion	GMA is mainly used in patients with haematological malignancies or in those who have undergone haematopoietic stem cell transplantation (HSCT).	22385270
Clostridium difficile colitis	Stem Cell Exhaustion	Clostridium difficile infection after allogeneic hematopoietic stem cell transplantation: incidence, risk factors, and outcome.	22387347
Clostridium difficile, Clostridium difficile enteritis, Communicable Diseases	Stem Cell Exhaustion	Clostridium difficile (C. difficile) infection was observed in 13% of recipients after hematopoietic stem cell transplantation (HSCT), mainly in the first month posttransplantation.	22387347
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Risk factors were cord blood as the source of stem cells, acute graft-versus-host disease (GVHD), and total body irradiation (TBI).	22387347
Graft-vs-Host Disease, Acute GVH disease, Central Diabetes Insipidus	Stem Cell Exhaustion	TBI in the conditioning regimen, cord blood as the source of stem cells, and acute graft-versus-host disease (aGVHD) were independently associated with CDI.	22387347
Duodenal Ulcer	Stem Cell Exhaustion	Through a genome-wide association analysis with a total of 7,035 individuals with duodenal ulcer and 25,323 controls from Japan, we identified two susceptibility loci at the PSCA gene (encoding prostate stem cell antigen) at 8q24 and at the ABO blood group locus at 9q34.	22387998
Chronic liver disease	Stem Cell Exhaustion	Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.	22388089
Brain Injury, Chronic	Stem Cell Exhaustion	During chronic injury a population of bipotent hepatic progenitor cells (HPCs) become activated to regenerate both cholangiocytes and hepatocytes.	22388089
Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Mitoxantrone, etoposide, cytarabine, and melphalan (NEAM) followed by autologous stem cell transplantation for patients with chemosensitive aggressive non-Hodgkin lymphoma.	22388671
Lymphoma, Non-Hodgkin, Familial, Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Patients with chemosensitive aggressive non-Hodgkin lymphoma (NHL) could benefit from high-dose chemotherapy (HDC) followed by autologous stem cell transplantation (auto-SCT).	22388671
Hematologic Neoplasms, Immunocompromised Host	Stem Cell Exhaustion	Of 320 cases studied, 115 (36%) occurred in immunocompromised patients, including: solid or hematological malignancy (97), corticosteroids or other immunosuppressive drugs (44), solid organ or stem cell transplant (five), and other conditions (eight).	22390624
Thalassemia	Stem Cell Exhaustion	Rare complications after second hematopoietic stem cell transplantation for thalassemia major.	22395220
Paralysed, Thalassemia, Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	We describe an 11-year-old girl with thalassemia major who underwent a second hematopoietic stem cell transplantation from a matched related donor and who subsequently developed posttransplant lymphoproliferative disorder complicated by severe ascending paralysis resembling Guillian-Barre syndrome.	22395220
Hemoglobinopathies	Stem Cell Exhaustion	This case highlights the dilemma surrounding second hematopoietic stem cell transplantations in hemoglobinopathies and the need for a careful, well informed, and collaborative decision-making process by patients, families, and medical professionals.	22395220
Malignant neoplasm of stomach, Specialty Type - cancer	Stem Cell Exhaustion	Expressions of putative cancer stem cell markers ABCB1, ABCG2, and CD133 are correlated with the degree of differentiation of gastric cancer.	22395309
Malignant neoplasm of stomach, Specialty Type - cancer	Stem Cell Exhaustion	The present study was carried out to determine whether a quantitative relationship exists between the expressions of 3 cancer stem cell (CSC) markers and the degree of differentiation of gastric cancer.	22395309
Sui Chinese, Urinary Stress Incontinence	Stem Cell Exhaustion	On October 18, 2010, in "Fundeni" Clinic of Urology and Renal Transplantation we performed for the first time in Romania, stem cell implantation in the urethral sphincter in four patients with stress urinary incontinence and compared the results of the urodynamic investigations of female patients operated with pure SUI with other surgical techniques.	22395514
Urinary Stress Incontinence	Stem Cell Exhaustion	Assessing the latest minimally invasive procedures of intra and perisphincterian injection of autologous stem cells and to compare the urodynamic results at one year after different surgical procedures for genuine stress urinary incontinence by measuring their impact on urinary flow rate (Qmax) and bladder pressure at Qmax during micturition.	22395514
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Allogeneic stem cell transplant for chronic myeloid leukemia as a still promising option in the era of the new target therapy.	22397295
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Thus, the place and usage of allogeneic stem cell transplant (SCT) in CML treatment--as a former "nearly monopolistic" therapeutic manner--is nowadays controversial.	22397295
Eccrine dermal cylindroma, Neoplasms	Stem Cell Exhaustion	Cylindroma is a benign skin appendageal tumor arising from pluripotent stem cells in the folliculo-sebaceous-apocrine unit.	22398229
Decreased platelet count	Stem Cell Exhaustion	Immunosuppressive function of mesenchymal stem cells from human umbilical cord matrix in immune thrombocytopenia patients.	22398715
Autoimmune Diseases, Inflammatory disorder	Stem Cell Exhaustion	Human umbilical cord matrix/Wharton's jelly (hUC)-derived mesenchymal stem cells (MSC) have been shown to have marked therapeutic effects in a number of inflammatory diseases and autoimmune diseases in humans based on their potential for immunosuppression and their low immunogenicity.	22398715
Multiple Myeloma	Stem Cell Exhaustion	This study investigated the impact of prognostic variables, including the distance a patient lives from a transplant center, on the outcome of autologous hematopoietic stem cell transplantation (ASCT) for multiple myeloma.	22398804
Adult Glioblastoma, Specialty Type - cancer	Stem Cell Exhaustion	It is required for cell cycle progression and survival in established glioblastoma cell lines and cancer stem cell-enriched cells.	22399192
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Our results showed that sex-determining region Y-box 2 expression may be a potential marker related to tumor recurrence, as implicated by its role in cancer stem cells.	22401770
Impaired T cell function	Stem Cell Exhaustion	Myostatin is associated with age-related human muscle stem cell dysfunction.	22403007
Impaired	Stem Cell Exhaustion	OMs had 35% fewer basal stem cells and a type II fiber-specific impairment in stem cell content and proliferation.	22403007
Impaired T cell function	Stem Cell Exhaustion	Stem cell-specific myostatin levels were not different at baseline; however, there were 67% more myostatin-positive type II-associated stem cells in OMs at 24 h. These data illustrate an age-related impairment of stem cell function in a fiber type-specific manner.	22403007
Cataract	Stem Cell Exhaustion	Efficient generation of lens progenitor cells from cataract patient-specific induced pluripotent stem cells.	22403680
Cataract	Stem Cell Exhaustion	Our study describes a highly efficient procedure for generating lens progenitor cells from cataract patient HLEC-derived iPSCs.	22403680
hetastarch	Stem Cell Exhaustion	However, NPC is a systemic disease; therefore the purpose of this study was to find the possibility of a general therapeutic effect by applying and tracking transplanted human amniotic epithelial stem cells (hAESC) in NPC mice.	22404083
Multiple Myeloma	Stem Cell Exhaustion	A single-center retrospective analysis compared two consecutive cohorts undergoing FIL or PEG mobilization before autologous hematopoietic stem cell transplantation for multiple myeloma or lymphoma.	22404694
Cessation of life, Dyspnea, CTCAE	Stem Cell Exhaustion	Products cryopreserved with dimethyl sulfoxide (DMSO) in stem cell transplant (SCT) often cause many adverse effects during their infusion (major cardiovascular events, dyspnea ... even death).	22404870
malignant disease	Stem Cell Exhaustion	Intravenous (IV) busulfan (Bu) dosing approved in Europe based on 5 body weight (BW) strata has been validated for targeting Bu exposures in children undergoing hematopoietic stem-cell transplantation and with mostly malignant diseases.	22406655
Keloid	Stem Cell Exhaustion	Identification of fibrocytes from mesenchymal stem cells in keloid tissue: a potential source of abnormal fibroblasts in keloid scarring.	22407077
Keloid	Stem Cell Exhaustion	Therefore, we hypothesized that a population of fibrocytes is present in keloid tissue as opposed to the mesenchymal stem cells (MSCs).	22407077
Specialty Type - cancer	Stem Cell Exhaustion	Recently, evidence in support of the cancer stem cell (CSC) hypothesis has been accumulating.	22407396
Childhood Breast Carcinoma, Primary malignant neoplasm	Stem Cell Exhaustion	On the other hand, it has been reported that the expression of aldehyde dehydrogenase 1 (ALDH1) in primary breast cancer is a powerful predictor of a poor clinical outcome, and that breast cancer stem cells express ALDH1.	22407396
Disease, palladium, Parkinson Disease	Stem Cell Exhaustion	Induced pluripotent stem cells (iPSC) offer an unprecedented opportunity to model human disease in relevant cell types, but it is unclear whether they could successfully model age-related diseases such as Parkinson's disease (PD).	22407749
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	We determined the prognostic significance of MYC rearrangement in patients with relapsed/refractory DLBCL prospectively treated by R-ICE or R-DHAP followed by high-dose therapy and autologous stem cell transplantation.	22408263
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Plerixafor with granulocyte-colony-stimulating factor (G-CSF) has been shown to enhance stem cell mobilization in patients with multiple myeloma and lymphoma with previous mobilization failure.	22414093
Rheumatoid Arthritis, Degenerative polyarthritis	Stem Cell Exhaustion	Chondrogenic differentiation of human subchondral progenitor cells is affected by synovial fluid from donors with osteoarthritis or rheumatoid arthritis.	22414301
Rheumatoid Arthritis, Degenerative polyarthritis	Stem Cell Exhaustion	These results suggest that in RA, SF may impair cartilage repair by subchondral mesenchymal progenitor cells in microfracture, while in OA, SF may has no negative, but a delaying effect on the cartilage matrix formation.	22414301
Neurodegenerative Disorders	Stem Cell Exhaustion	Advances in stem cell biology have generated intense interest in the prospect of transplanting stem cells into the nervous system for the treatment of neurodegenerative diseases.	22415942
Amyotrophic Lateral Sclerosis	Stem Cell Exhaustion	Lumbar intraspinal injection of neural stem cells in patients with amyotrophic lateral sclerosis: results of a phase I trial in 12 patients.	22415942
Toxic effect, Bone necrosis, Multiple Myeloma	Stem Cell Exhaustion	Hematopoietic progenitor cell transplantation toxicities in multiple myeloma patients with bisphosphonate-induced osteonecrosis of the jaw: a longitudinal cohort study.	22418599
Multiple Myeloma, Bone necrosis, Toxic effect, Osteonecrosis of Jaw, Morular Metaplasia of the Endometrium	Stem Cell Exhaustion	There is no information regarding the toxicity associated with autologous hematopoietic progenitor cell transplantation (AHPCT) in patients with multiple myeloma (MM) who have bisphosphonate-induced osteonecrosis of the jaw (ONJ).	22418599
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Myelodysplastic syndromes are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis.	22419576
Chronic myeloproliferative disorder, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myeloid leukemia is a chronic myeloproliferative disorder of hematopoietic stem cells that occurs in 10% of cases in women of childbearing age.	22421368
Precursor cell lymphoblastic lymphoma, Acute lymphocytic leukemia	Stem Cell Exhaustion	Phase II study of intensive post-remission chemotherapy and stem cell transplantation for adult acute lymphoblastic leukemia and lymphoblastic lymphoma: Japan Clinical Oncology Group Study, JCOG9402.	22422899
Communicable Diseases	Stem Cell Exhaustion	After receiving an allogeneic haematopoietic stem cell transplant, he developed a necrotizing infection of the right midface.	22425500
Malignant Neoplasms	Stem Cell Exhaustion	Stem cell marker LIN28, related closely with SOX2 and OCT4, has been studied as a biomarker for the maintainance of pluripotent cells in several malignancies.	22429493
Communicable Diseases	Stem Cell Exhaustion	The use of a neutropenic diet (ND) after hematopoietic stem cell transplantation (HSCT) was instituted more than 30 years ago as a means of preventing infection from organisms colonizing the gastrointestinal tract.	22430084
Multiple Myeloma	Stem Cell Exhaustion	Prognostic impact of serum immunoglobulin heavy/light chain ratio in patients with multiple myeloma in complete remission after autologous stem cell transplantation.	22430087
Multiple Myeloma	Stem Cell Exhaustion	Immunoglobulin heavy/light chain (HLC) ratios were studied in 37 patients with multiple myeloma in complete remission after autologous hematopoietic stem cell transplantation.	22430087
Amyotrophic Lateral Sclerosis	Stem Cell Exhaustion	Two potential biomarkers identified in mesenchymal stem cells and leukocytes of patients with sporadic amyotrophic lateral sclerosis.	22430187
CYFIP2 gene, Retinoblastoma, Antilymphocyte Serum	Stem Cell Exhaustion	To this end we use human mesenchymal stem cells (hMSC) derived from the bone marrow of six ALS patients (ALS hMSC) and identified two genes, Cytoplasmic FMR Interacting Protein 2 (CyFIP2) and Retinoblastoma (Rb) Binding Protein 9 (RbBP9) with a significant decrease in post transcriptional A to I RNA editing compared to hMSC of healthy individuals.	22430187
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Neoplasms	Stem Cell Exhaustion	Rescue by hematopoietic progenitor cells derived from engrafted cord blood unit in a child with brain tumor after transplantation for T-cell acute lymphoblastic leukemia.	22430590
Carcinogenic Chlorinated Hydrocarbon, Hollings Cancer Center	Stem Cell Exhaustion	The present results show that both HCC and CC components of most of the CHCs expressed both HCC and CC phenotypes, supporting the hypothesis that CHC originates from a hepatic progenitor cell capable of differentiating into hepatocytes and cholangiocytes.	22431178
Childhood Breast Carcinoma	Stem Cell Exhaustion	Immunohistochemical detection of breast cancer stem cells in hormone receptor-positive breast cancer and their role in response to endocrine therapy and clinical outcome.	22433454
Malignant neoplasm of breast, Childhood Breast Carcinoma	Stem Cell Exhaustion	Breast cancer stem cells are rich in triple negative or human epidermal growth factor receptor-2-positive breast cancers.	22433454
Hormone Receptor Positive Breast Carcinoma	Stem Cell Exhaustion	The role of these stem cells in hormone receptor-positive breast cancers is unknown.	22433454
Hormone Receptor Positive Breast Carcinoma	Stem Cell Exhaustion	Therefore, we launched this retrospective biomarker analysis to clarify the role of stem cells in relation with endocrine therapy in hormone receptor-positive breast cancer.	22433454
Malignant tumor of colon	Stem Cell Exhaustion	Characterization of colon cancer cells: a functional approach characterizing CD133 as a potential stem cell marker.	22433494
Colon Carcinoma	Stem Cell Exhaustion	We characterized a panel of fourteen human colon carcinoma cell lines and their corresponding xenografts for the surface expression of potential stem cell markers CD133, CD24, CD44, CDCP1 and CXCR4.	22433494
Neoplasms	Stem Cell Exhaustion	All five putative stem cell markers showed distinct expression patterns in the tumours examined.	22433494
Colon Carcinoma	Stem Cell Exhaustion	Our data revealed correlations in the expression of surface markers CD44 and CD24 as well as CD44 and CDCP1 and strongly suggest that CD133 is a stem cell marker within our colon carcinoma panel.	22433494
Mantle cell lymphoma	Stem Cell Exhaustion	Reduced-intensity conditioning allogeneic stem cell transplantation for relapsed/refractory mantle cell lymphoma: a multicenter experience.	22440229
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	Despite therapeutic approach that combines rituximab-containing chemotherapy, followed or not by autologous stem cell transplantation (auto-SCT), mantle cell lymphoma (MCL) patients experience relapses.	22440229
Aggressive behavior, Specialty Type - cancer, Pancreatic carcinoma	Stem Cell Exhaustion	Thus, high FGFR-2 IIIc levels in PDAC contribute to disease aggressiveness and confer to pancreatic cancer cells features suggestive of cancer stem cells, indicating that FGFR-2 IIIc may be a novel and important therapeutic target in PDAC.	22440254
Aortic Aneurysm, Thoracic	Stem Cell Exhaustion	Stem cells in thoracic aortic aneurysms and dissections: potential contributors to aortic repair.	22440369
1,3,4,6-tetra-O-acetyl-2-azido-2-deoxyglucopyranose	Stem Cell Exhaustion	Although multipotent stem cells (SCs) are important in tissue repair, their role in TAAD is unknown.	22440369
1,3,4,6-tetra-O-acetyl-2-azido-2-deoxyglucopyranose	Stem Cell Exhaustion	Stem cells are more abundant in TAAD tissue than in normal aortic tissue.	22440369
Multiple Myeloma	Stem Cell Exhaustion	To prospectively evaluate allogeneic stem cell transplantation (allo-SCT) for myeloma as part of first-line therapy, a donor versus no-donor analysis was performed of patients treated in the HOVON-50 study, a study that was originally designed to examine thalidomide combined with intensive therapy.	22442350
Prostate carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM.	22442719
Prostate carcinoma, Specialty Type - cancer, Passive Cutaneous Anaphylaxis, Hormone refractory prostate cancer	Stem Cell Exhaustion	The emergence of castrate-resistant prostate cancer (CRPC) contributes to the high mortality of patients diagnosed with prostate cancer (PCa), which in part could be attributed to the existence and the emergence of cancer stem cells (CSCs).	22442719
Malignant Head and Neck Neoplasm	Stem Cell Exhaustion	Long-term cryopreservation model of rat salivary gland stem cells for future therapy in irradiated head and neck cancer patients.	22443349
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Mobilized peripheral blood stem cells compared with bone marrow as the stem cell source for unrelated donor allogeneic transplantation with reduced-intensity conditioning in patients with acute myeloid leukemia in complete remission: an analysis from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation.	22446014
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Reduced-intensity conditioning allogeneic stem cell transplant (RIC-alloSCT) is being increasingly used for patients with acute myelogenous leukemia (AML) with comorbidities.	22446014
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Patients without chronic graft-versus-host disease (cGVHD) have robust B cell reconstitution and are able to maintain B cell homeostasis after allogeneic hematopoietic stem cell transplantation (HSCT).	22446015
Multiple Myeloma	Stem Cell Exhaustion	Lenalidomide plus donor-lymphocytes infusion after allogeneic stem-cell transplantation with reduced-intensity conditioning in patients with high-risk multiple myeloma.	22446605
Cessation of life	Stem Cell Exhaustion	Myeloma relapse is the main cause of death after allogeneic stem cell transplantation.	22446605
Graft-vs-Host Disease	Stem Cell Exhaustion	Lenalidomide is well tolerated after allogeneic stem cell transplantation; the combination with DLI did not cause a higher risk of graft-vs-host disease; an immunological synergistic effect was probably present with this strategy.	22446605
Multiple Myeloma	Stem Cell Exhaustion	A simplified method for autologous stem cell transplantation in multiple myeloma.	22446610
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We evaluated the efficacy and safety of non-cryopreserved storage of autologous hematopoietic stem cells with no post-transplant granulocyte colony-stimulating factor (G-CSF) support in adult patients undergoing autologous stem cell transplantation (ASCT) for multiple myeloma (MM).	22446610
Malignant Neoplasms	Stem Cell Exhaustion	T-cell replete fludarabine/cyclophosphamide reduced intensity allogeneic stem cell transplantation for lymphoid malignancies.	22449197
Graft-vs-Host Disease, Malignant Neoplasms	Stem Cell Exhaustion	The relative merits of reduced-intensity allogeneic stem cell transplantation (RISCT) for high-risk indolent lymphoid malignancies are emerging, although the preferred conditioning regimen to manage the risks of graft-versus-host disease (GVHD) is not clearly defined.	22449197
Acute myocardial infarction	Stem Cell Exhaustion	To determine whether newer combination cytokine treatment with granulocyte colony-stimulating factor (G-CSF) and darbepoetin can improve efficacy of stem cell therapy, we evaluated safety and peripheral blood stem/progenitor cell (PBSC) mobilizing effects of combination cytokine in comparison with G-CSF alone in patients with acute myocardial infarction (AMI).	22449332
Bladder neck obstruction	Stem Cell Exhaustion	The present study is to investigate if human mesenchymal stem cells (MSCs) are capable of inhibiting collagen deposition and improve cystometric parameters in bladder outlet obstruction in rats.	22449414
Atherosclerosis	Stem Cell Exhaustion	CV progenitor cells, including CD34+ cells, play a role in delaying the progression of atherosclerosis.	22449458
Barrett Esophagus	Stem Cell Exhaustion	Cdx2 expression in esophageal stem cells induced by reflux bile acids may be an important factor for development of Barrett's esophagus, whereas Notch signaling is a molecular signaling pathway that plays an important role in the determination of cell differentiation.	22449796
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	[Sustained complete molecular remission after cessation of imatinib mesylate treatment in a patient with relapsed chronic myelogenous leukemia after allogeneic stem cell transplantation].	22450581
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We present a case with sustained complete molecular response (CMR) after cessation of two months of imatinib mesylate (IM) treatment for chronic myelogenous leukemia (CML) relapsed after allogeneic stem cell transplantation (Allo-SCT).	22450581
Multiple Myeloma	Stem Cell Exhaustion	[B-cell acute lymphoblastic leukemia developed 5 years after autologous stem cell transplantation for multiple myeloma].	22450582
Renal dysfunction	Stem Cell Exhaustion	It was difficult for him to receive hemopoietic stem cell transplantation because of his advanced age and renal dysfunction.	22450587
Blastic plasmacytoid dendritic cell neoplasm	Stem Cell Exhaustion	Although previously not reported, ABVD therapy is useful for patients with blastic plasmacytoid dendritic cell neoplasm who cannot receive hemopoietic stem cell transplantation.	22450587
Communicable Diseases	Stem Cell Exhaustion	According to a model described by Balducci, the human myelopoietic stem cell reserve shows a shift from the reproductive to the proliferative pool corresponding to higher immunological demands resulting from the breakdown of infection defences.	22451304
Sepsis	Stem Cell Exhaustion	Every "hematopoietic stress," i.e., sepsis and/or cytoreductive chemotherapy, leads to a reduction of myelopoietic stem cells in the elderly in contrast to an increase in younger individuals.	22451304
Coronary Arteriosclerosis	Stem Cell Exhaustion	Blood levels of stem cell marker proteins CD34 and osteonectin were studied in male patients with coronary atherosclerosis by direct biomagnetic separation of proteins with magnetic microspheres using the PureProteome Protein A and Protein G Magnetic Beads proteomic technology.	22451890
Atherosclerosis, Calcinosis	Stem Cell Exhaustion	The results indicate that osteonectin as a marker of stromal stem cells with osteogenic potential presumably plays an important role in atherogenesis and can serve as a new biomarker of stenosing atherosclerosis and calcinosis of coronary arteries.	22451890
Multiple Myeloma	Stem Cell Exhaustion	Melphalan 180 mg/m2 can be safely administered as conditioning regimen before an autologous stem cell transplantation (ASCT) in multiple myeloma patients with creatinine clearance 60 mL/min/1.73 m2 or lower with use of palifermin for cytoprotection: results of a phase I trial.	22453252
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	In this multinational, open-label, phase II study, the efficacy and safety of brentuximab vedotin were evaluated in patients with relapsed or refractory Hodgkin's lymphoma (HL) after autologous stem-cell transplantation (auto-SCT).	22454421
FLT3 Internal Tandem Duplication	Stem Cell Exhaustion	FLT3-ITD is associated with poor clinical outcome and is an indication for allogeneic stem cell transplantation (allo-SCT).	22458420
leukemia	Stem Cell Exhaustion	Most patients had leukemia, 44 underwent high-dose chemotherapy, and 18 underwent stem cell transplantation.	22459769
Liver Failure, Chronic graft-versus-host disease	Stem Cell Exhaustion	Liver transplantation in a child with liver failure due to chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation from the same unrelated living donor.	22462486
BCR gene	Stem Cell Exhaustion	The boy received an allogeneic hematopoietic stem cell transplant at the age of two yr because of early recurrence of ALL.	22462486
Graft-vs-Host Disease, Liver Cirrhosis	Stem Cell Exhaustion	Liver biopsy showed liver GVHD resulting in liver cirrhosis by the age of five yr. LTx was performed with a left liver lobe from the unrelated donor from whom the stem cells had been taken.	22462486
Acute myocardial infarction	Stem Cell Exhaustion	Treatment of acute myocardial infarction with stem cell transplantation has achieved beneficial effects in many clinical trials.	22462635
Overweight, "cytidylyl-(3-5)-cytidine	Stem Cell Exhaustion	To assess the effect of a personalized physical activity programme on weight and circulating (CPC) and endothelial progenitor cells (EPC) in overweight and obese subjects.	22463054
Communicable Diseases	Stem Cell Exhaustion	Healthcare-associated infection in hematopoietic stem cell transplantation patients: risk factors and impact on outcome.	22463920
Infections, Hospital, Infection	Stem Cell Exhaustion	The objective of this study was to analyze the incidence of and risk factors for healthcare-associated infections (HAI) among hematopoietic stem cell transplantation (HSCT) patients, and the impact of such infections on mortality during hospitalization.	22463920
Specialty Type - cancer	Stem Cell Exhaustion	We also assessed other claudin-low features, such as the cancer stem cell-like and epithelial-to-mesenchymal transition phenotypes.	22464177
Specialty Type - cancer	Stem Cell Exhaustion	Regarding the cancer stem cell marker ALDH1, 30.8% (4/13) showed positive staining.	22464177
Childhood Breast Carcinoma, Metaplastic carcinoma of breast	Stem Cell Exhaustion	The negative/low expression of claudins and E-cadherin, high levels of vimentin, and the breast cancer stem cell phenotype suggests that metaplastic breast carcinomas have similar features to the ones included in the claudin-low molecular subtype, specially their mesenchymal components.	22464177
Neoplasms	Stem Cell Exhaustion	The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor.	22464327
Neoplasms	Stem Cell Exhaustion	These results shed light on the relationship between proliferative and quiescent intestinal stem cells and support a model in which intestinal stem cell quiescence is maintained by calibrated ErbB signaling with loss of a negative regulator predisposing to neoplasia.	22464327
Childhood Breast Carcinoma, Neoplasms	Stem Cell Exhaustion	In this study, TIMP-1 production was studied in a co-culture model of hormone-independent breast cancer cell lines and mesenchymal stem cells mimicking the stromal components of the tumor.	22465225
Childhood Breast Carcinoma	Stem Cell Exhaustion	Co-culturing of mesenchymal stem cells and breast cancer cells resulted in positive immunocytochemical diffuse staining for TIMP-1 for both cell types.	22465225
Retinal Detachment	Stem Cell Exhaustion	Furthermore, cells isolated from vitreous samples obtained during vitrectomies for retinal detachment were directly fixed or cultured in a stem cell-promoting medium and compared to cells cultured from the post-mortem retina and CE.	22465407
trauma qualifier	Stem Cell Exhaustion	In addition to the ability for self-renewal and functional differentiation, neural stem/progenitor cells (NSCs) can respond to CNS injuries by targeted migration.	22465407
Peripheral	Stem Cell Exhaustion	In conclusion, the adult human eye may harbor two different populations of neuroepithelial stem/progenitor cells; a non-glial population located in the proximal pars plana around peripheral cysts in addition to a population with Muller glia characteristics.	22465407
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Overall survival of chronic myeloid leukemia patients treated with related donor hematopoietic stem cell transplant or imatinib.	22468479
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	To determine the overall survival (OS) of Ph1 positive chronic myeloid leukemia (CML) patients treated with allogeneic hematopoietic stem cell transplant (AHSCT) vs. imatinib.	22468479
Pleuropulmonary blastoma, Follicular thyroid carcinoma	Stem Cell Exhaustion	Follicular thyroid carcinoma arising after hematopoietic stem cell transplantation in a child with pleuropulmonary blastoma.	22468940
Mycoses	Stem Cell Exhaustion	Multicenter, randomized, open-label study comparing the efficacy and safety of micafungin versus itraconazole for prophylaxis of invasive fungal infections in patients undergoing hematopoietic stem cell transplant.	22469884
Neutropenia, Mycoses	Stem Cell Exhaustion	This multicenter, randomized, open-label phase III study compared the efficacy and safety of micafungin and itraconazole in prophylaxis of invasive fungal infections in neutropenic patients undergoing hematopoietic stem cell transplants in China.	22469884
CLU protein, human, Ischemia	Stem Cell Exhaustion	Stem cell therapy has been proposed to be an alternative therapy in patients with critical limb ischemia (CLI), not eligible for endovascular or surgical revascularization.	22472173
CLU protein, human	Stem Cell Exhaustion	Both IM and IA delivery of autologous stem cells are effective therapeutic strategies in patients with CLI.	22472173
Acquired aplastic anemia	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplant for adults over 40 years old with acquired aplastic anemia.	22472480
Aplastic Anemia	Stem Cell Exhaustion	Although younger age is associated with favorable prognosis in adults undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) for aplastic anemia (AA), other pretransplantation factors may be more important than age.	22472480
Primary central nervous system lymphoma	Stem Cell Exhaustion	Prognosis after high-dose chemotherapy followed by autologous stem-cell transplantation as first-line treatment in primary CNS lymphoma--a long-term follow-up study.	22473593
Primary central nervous system lymphoma	Stem Cell Exhaustion	High-dose chemotherapy followed by autologous stem-cell transplantation (HCT-ASCT) is a promising approach in eligible patients with primary central nervous system lymphoma (PCNSL).	22473593
Disease of capillaries, diabetic	Stem Cell Exhaustion	Amelioration of glucose control mobilizes circulating pericyte progenitor cells in type 2 diabetic patients with microangiopathy.	22474419
Coronary Arteriosclerosis, Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Procalcific phenotypic drift of circulating progenitor cells in type 2 diabetes with coronary artery disease.	22474430
Coronary Arteriosclerosis, Dominica, Diabetes Mellitus	Stem Cell Exhaustion	Diabetes mellitus (DM) alters circulating progenitor cells relevant for the pathophysiology of coronary artery disease (CAD).	22474430
Vascular calcification	Stem Cell Exhaustion	While endothelial progenitor cells (EPCs) are reduced, there is no data on procalcific polarization of circulating progenitors, which may contribute to vascular calcification in these patients.	22474430
diabetic	Stem Cell Exhaustion	In conclusion, circulating progenitor cells of diabetic patients show a phenotypic drift toward a pro-calcific phenotype that may be driven by inflammatory signals.	22474430
Specialty Type - cancer	Stem Cell Exhaustion	However, it was directly related to protein expression of the previously studied cancer stem cell marker Nestin (p = 0.01) and the gap junction protein claudin-7 (p = 0.02) and inversely related to the mRNA level of the E-cadherin repressor SIP1 (p = 0.02).	22476403
gliosarcoma	Stem Cell Exhaustion	The histogenesis of the osseous element in gliosarcomas is not well understood, and could be a result of a metaplastic change or divergent differentiation from a common progenitor cell.	22476731
Adenovirus Infections	Stem Cell Exhaustion	Incidence and treatment strategy for disseminated adenovirus disease after haploidentical stem cell transplantation.	22476883
Communicable Diseases	Stem Cell Exhaustion	Adenovirus (AdV) infection is an emerging complication in patients undergoing allogeneic stem cell transplantation (SCT) and is closely associated with delayed immune reconstitution.	22476883
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Despite extensive study, the use of allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia (AML) vary considerably.	22476996
Malignant neoplasm of stomach	Stem Cell Exhaustion	In anticipation of the urgent surgery for stomach cancer, an endothelial progenitor cell Genous capture stent (Orbus Neich Medical Technology) was implanted.	22477758
Hematologic Neoplasms, Neoplasms, Harvesting of peripheral blood stem cells	Stem Cell Exhaustion	We retrospectively reviewed medical records from a total of 248 patients affected by hematological malignancies or solid tumors undergoing peripheral blood stem cell collection following chemotherapy plus G-CSF.	22480954
Colorectal Carcinoma, Specialty Type - cancer, Cytogenetic Complete Response	Stem Cell Exhaustion	The activated leukocyte cell adhesion molecule (ALCAM, CD166) has been reported to be involved in tumorigenesis of colorectal cancer (CRC) and to function as a cancer stem cell marker.	22482754
Graft-vs-Host Disease	Stem Cell Exhaustion	We studied 172 patients for development of ocular graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (allo-SCT) from 2002 to 2009.	22484321
Multiple Myeloma	Stem Cell Exhaustion	Growth factor plus preemptive ('just-in-time') plerixafor successfully mobilizes hematopoietic stem cells in multiple myeloma patients despite prior lenalidomide exposure.	22484324
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Delayed formation of FancD2 foci in glioma stem cells treated with ionizing radiation.	22484854
Glioblastoma Multiforme Pathway, Malignant Neoplasms	Stem Cell Exhaustion	Its malignancy is in part due to cell populations refractory to radiotherapy and chemotherapy, which in some patients display stem properties (glioma stem cells-GSC).	22484854
Specialty Type - cancer, Neoplasms, Nanospheres	Stem Cell Exhaustion	In addition, we identified upregulation of these genes in the A375 cell line's side population (SP) and melanospheres, established methods to enrich for candidate cancer stem cells (CSCs), which are considered chemoresistant and tumorigenic, and thus proposed to be responsible for tumor relapse.	22486811
Staphylococcus epidermidis	Stem Cell Exhaustion	Linezolid-induced pure red cell aplasia in a patient with Staphylococcus epidermidis infection after allogeneic stem cell transplantation.	22487245
Kidney Failure, Myelosuppression, Bone Marrow Suppression	Stem Cell Exhaustion	It is important to be aware of the hematological effects associated with LZD in the setting of stem cell transplantation,particularly for those with pre-existing myelosuppression, renal insufficiency, and those receiving concomitant drugs that produce bone marrow suppression.	22487245
Atherosclerosis, Metabolic Syndrome X, ETV3 gene	Stem Cell Exhaustion	A reduction in EPC (endothelial progenitor cell) number could explain the development and progression of atherosclerosis in the MetS (metabolic syndrome).	22489903
Metabolic Syndrome X	Stem Cell Exhaustion	Moderate-to-high-intensity training and a hypocaloric Mediterranean diet enhance endothelial progenitor cells and fitness in subjects with the metabolic syndrome.	22489903
Hematologic Neoplasms	Stem Cell Exhaustion	The more, the less: age and chemotherapy load are predictive of poor stem cell mobilization in patients with hematologic malignancies.	22490480
Hematologic Neoplasms	Stem Cell Exhaustion	Intensive treatment such as autologous peripheral blood stem cell (PBSC) transplantation is an important therapeutic strategy in many hematologic malignancies.	22490480
Orthomyxoviridae	Stem Cell Exhaustion	These observations suggest the possible involvement of lung stem/progenitor cells in influenza virus infection.	22491467
Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease is a severe complication of allogeneic stem cell transplantation in which the functional immune cells of the donor recognize the recipient as foreign and mount an immunological attack.	22491736
Acute GVH disease	Stem Cell Exhaustion	In the present study, a novel bioinformatics framework was used to identify gene expression patterns associated with acute graft-versushost disease in patients undergoing allogeneic hematopoietic stem cell transplantation.	22491736
Acute GVH disease	Stem Cell Exhaustion	According to our integrated methodology, transcripts for FOXP3, ICOS, CD52 and CASP1, genes involved in immune alloreactive responses and participating in immune cell interactions, were identified as the most informative biomarkers in allogeneic stem cell transplant recipients experiencing acute graft-versus-host disease.	22491736
Primary Myelofibrosis, Chronic graft-versus-host disease	Stem Cell Exhaustion	Dynamic International Prognostic Scoring System scores, pre-transplant therapy and chronic graft-versus-host disease determine outcome after allogeneic hematopoietic stem cell transplantation for myelofibrosis.	22491742
Myeloproliferative disease, Primary Myelofibrosis	Stem Cell Exhaustion	Myelofibrosis is a myeloproliferative stem cell disorder curable exclusively by allogeneic hematopoietic stem cell transplantation and is associated with substantial mortality and morbidity.	22491742
Primary Myelofibrosis	Stem Cell Exhaustion	We retrospectively assessed 76 consecutive patients with primary (n=47) or secondary (n=29) myelofibrosis who underwent bone marrow (n=6) or peripheral blood stem cell (n=70) transplantation from sibling (n=30) or unrelated (n=46) donors between January 1994 and December 2010.	22491742
Primary Myelofibrosis	Stem Cell Exhaustion	The data corroborate a strong correlation between alloreactivity and long-term post-transplant disease control and confirm an inverse relationship between disease stage, pharmacotherapy and outcome after allogeneic hematopoietic stem cell transplantation for myelofibrosis.	22491742
Primary Myelofibrosis	Stem Cell Exhaustion	The Dynamic International Prognostic Scoring System was demonstrated to be useful for risk stratification of patients with myelofibrosis who are to undergo hematopoietic stem cell transplantation.	22491742
palladium	Stem Cell Exhaustion	Our findings indicate that future cell-based therapies using fetal tissue or stem cells in PD patients may require additional grafts of serotonergic neurons to relieve nonmotor symptoms by restoring serotonergic neurotransmission in specific cerebral targets.	22491951
Central neuroblastoma	Stem Cell Exhaustion	Thiotepa and melphalan based single, tandem, and triple high dose therapy and autologous stem cell transplantation for high risk neuroblastoma.	22492714
HD Term Type	Stem Cell Exhaustion	Consolidation with high-dose (HD) chemotherapy and autologous stem cell transplantation (ASCT) has been intensified with tandem and triple cycles with promising results.	22492714
Neoplasms	Stem Cell Exhaustion	One hundred tumour samples of CUP were loaded in tissue microarrays and were studied for immunohistochemical (IHC) expression of E-cadherin, N-cadherin, vimentin, the EMT transcription factor (SNAIL) and the stem cell marker octamer-binding transcription marker 4(OCT4).	22493359
Leukemia, T-Cell	Stem Cell Exhaustion	Allogeneic stem-cell transplantation from matched, related donors was associated with improved outcomes in T-cell leukemia.	22494120
Leukemia, T-Cell	Stem Cell Exhaustion	Patients who have T-cell leukemia appear to have a better outcome with allogeneic stem-cell transplantation than with chemotherapy, whereas patients who have precursor B-cell leukemia without other adverse features appear to have a better outcome with chemotherapy.	22494120
melanoma	Stem Cell Exhaustion	Cells from surgical specimens of nodular melanoma were grown as anchorage-independent melanospheres in a stem cell medium and as adherent monolayer cultures in the presence of serum.	22495670
Acute leukemia	Stem Cell Exhaustion	Reduced-intensity conditioning transplantation in acute leukemia: the effect of source of unrelated donor stem cells on outcomes.	22496153
Ischemia	Stem Cell Exhaustion	Safety and effect of adipose tissue-derived stem cell implantation in patients with critical limb ischemia: a pilot study.	22498564
CLU protein, human	Stem Cell Exhaustion	The safety and efficacy of multiple intramuscular adipose tissue-derived mesenchymal stem cells (ATMSC) injections in CLI patients was determined in the study.	22498564
Myeloid neoplasm	Stem Cell Exhaustion	[Allogeneic hematopoietic stem cell transplantation with fludarabine, melphalan, and total body irradiation as a conditioning for elderly patients with myeloid malignancies].	22499048
Hematologic Neoplasms	Stem Cell Exhaustion	A variety of reduced-intensity conditionings have been used in the reported studies of allogeneic hematopoietic stem cell transplantation (HSCT) for elderly patients with myeloid hematological malignancies.	22499048
Eosinophil count raised (finding)	Stem Cell Exhaustion	Eosinophilia, regardless of degree, is related to better outcomes after allogeneic hematopoietic stem cell transplantation.	22504238
Up, Urogenital Abnormalities	Stem Cell Exhaustion	We conclude that neurogenic abnormalities in AD differ between phases and areas of neurogenesis and stages of AD; while hippocampal stem cells (Musashi-1) decrease, proliferation (nestin) increases and differentiation/migration phase as well as axonal/dendritic targeting (doublecortin and b-III-tubulin) remains virtually unchanged.	22504537
Up	Stem Cell Exhaustion	This suggests an attenuation of stem cells together with compensatory increased proliferation that, however, does not result in an increased number of migratory neuroblasts and differentiated neurons in AD.	22504537
Bladder neck obstruction	Stem Cell Exhaustion	Mesenchymal stem cells overexpressing hepatocyte growth factor (HGF) inhibit collagen deposit and improve bladder function in rat model of bladder outlet obstruction.	22506988
Bladder neck obstruction, BCL2L10 wt Allele	Stem Cell Exhaustion	This study was performed to examine the capability of human mesenchymal stem cells (MSCs) overexpressing hepatocyte growth factor (HGF) to inhibit collagen deposition in rat model of bladder outlet obstruction (BOO).	22506988
Acute Coronary Syndrome	Stem Cell Exhaustion	Endothelial progenitor cells are suppressed in anemic patients with acute coronary syndrome.	22507545
Ischemia	Stem Cell Exhaustion	Endothelial progenitor cells are bone marrow-derived cells that are mobilized into the circulation in response to ischemia.	22507545
Acute Coronary Syndrome	Stem Cell Exhaustion	The number of circulating endothelial progenitor cells increases within days of acute coronary syndrome.	22507545
Anemia, Acute Coronary Syndrome	Stem Cell Exhaustion	There is no confirmation regarding the correlation between the occurrence of anemia and the deficiency in endothelial progenitor cells in patients with acute coronary syndrome.	22507545
Anemia, Acute Coronary Syndrome	Stem Cell Exhaustion	The correlation between chronic anemia and endothelial progenitor cells in patients with acute coronary syndrome was investigated.	22507545
Acute Coronary Syndrome	Stem Cell Exhaustion	Endothelial progenitor cells were examined in 26 patients with acute coronary syndrome.	22507545
Anemia, Acute Coronary Syndrome	Stem Cell Exhaustion	Patients with acute coronary syndrome with anemia demonstrate a reduced number of peripheral endothelial progenitor cells with impaired function, possibly representing a lower capacity for vascular healing.	22507545
Antilymphocyte Serum	Stem Cell Exhaustion	Feasibility, safety, and preliminary proof of principles of autologous neural stem cell treatment combined with T-cell vaccination for ALS patients.	22507681
Antilymphocyte Serum	Stem Cell Exhaustion	TCV in conjunction with an autologous neural stem cell treatment might be a feasible, minimally invasive, safe, and effective approach to obtain enduring therapeutic effects in ALS patients.	22507681
Multiple Myeloma	Stem Cell Exhaustion	The next step forward was the use of high-dose melphalan followed by stem cell support (autologous stem cell transplant - ASCT) for young myeloma patients, which resulted in a significant improvement in disease free survival and overall survival.	22507766
Aplastic Anemia	Stem Cell Exhaustion	Search terms included severe aplastic anemia, HLA-matched sibling, unrelated donor, hematopoietic stem cell transplantation.	22507769
Graft-vs-Host Disease, Cessation of life	Stem Cell Exhaustion	The use of peripheral blood progenitor cells has also contributed to higher GVHD risks and consequently excess deaths.	22507769
Coinfection, HIV	Stem Cell Exhaustion	A number of challenges are faced in terms of reimbursement of drugs, simultaneous co-infection with human immunodeficiency virus, access to allogeneic stem cell transplantation and, until recently, a lack of local recommendations appropriate for our setting.	22507786
Carcinoma	Stem Cell Exhaustion	These combined carcinomas may arise from enterochromaffin cells or totipotential stem cell in the esophagus or transdifferentiation of one element to another.	22509088
Graft-vs-Host Disease	Stem Cell Exhaustion	Cytokines in tear fluid of patients with ocular graft-versus-host disease after allogeneic stem cell transplantation.	22509110
Graft-vs-Host Disease	Stem Cell Exhaustion	To investigate the profile of cytokines in tear fluid of patients after allogeneic stem cell transplantation (allo-SCT) and determine their relation to the presence and manifestations of ocular graft-versus-host disease (GvHD).	22509110
Restenosis	Stem Cell Exhaustion	Hematopoietic progenitor cells and restenosis after carotid endarterectomy.	22511008
Vascular System Injuries	Stem Cell Exhaustion	Hematopoietic progenitor cells (HPCs) may attenuate the response to vascular injury by maintaining endothelial integrity and function.	22511008
Acute lymphocytic leukemia	Stem Cell Exhaustion	High curability via intensive reinduction chemotherapy and stem cell transplantation in young adults with relapsed acute lymphoblastic leukemia in Sweden 2003-2007.	22511497
Acute lymphocytic leukemia	Stem Cell Exhaustion	Allogeneic stem cell transplantation remains the treatment of choice for young adults with relapsed acute lymphoblastic leukemia.	22511497
Muscular Dystrophy, Duchenne, Cardiomyopathies	Stem Cell Exhaustion	To investigate whether cardiac progenitor cells (CPCs) isolated from healthy and GRMD dogs may differentiate into myocardial cell types and to test the feasibility of cell therapy for cardiomyopathies in a preclinical model of DMD, CPCs were isolated from cardiac biopsies of healthy and GRMD dogs.	22513051
Ischemic stroke	Stem Cell Exhaustion	Temporal profile of molecular signatures associated with circulating endothelial progenitor cells in human ischemic stroke.	22513751
Ischemic stroke	Stem Cell Exhaustion	Endothelial progenitor cells (EPC) have been associated with good functional outcome in ischemic stroke.	22513751
Acute Megakaryocytic Leukemias	Stem Cell Exhaustion	2 children with unknown trisomy 21 mosaic were diagnosed as acute megakaryoblastic leukemia (AMKL) and treated according the high risk arm of the AML-BFM 2004 including allogeneic stem cell transplantation in one child).	22513796
Retinal Pigments	Stem Cell Exhaustion	Differentiation of human pluripotent stem cells to retinal pigmented epithelium in defined conditions using purified extracellular matrix proteins.	22514096
methyldopa, Retinal Diseases, Retinal Pigments	Stem Cell Exhaustion	A potential application of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) is the generation of retinal pigmented epithelium (RPE) to treat age-related macular degeneration (AMD), a common but incurable retinal disease.	22514096
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Comparison of allogeneic stem cell transplantation from familial-mismatched/haploidentical donors and from unrelated donors in adults with high-risk acute myelogenous leukemia.	22516055
Central neuroblastoma	Stem Cell Exhaustion	New therapies for children with high risk neuroblastoma are needed, and haploidentical stem cell transplantation with NK post-graft injections is a potential option.	22516232
Neoplasms	Stem Cell Exhaustion	The aim of this work is to optimize in vitro NK cytotoxicity assays, investigate the effect of interleukin stimulation on NK cells and use of antiGD2 antibodies against tumor target cells and finally establish an in vitro model for haploidentical stem cell transplantation.	22516232
Stomach Carcinoma, Histogenic Process, Cholangiocarcinoma	Stem Cell Exhaustion	The histogenesis of hepatoid gastric carcinoma expressing SALL4 seems to reflect fetal gut differentiation or involve the germ cell lineage and may be different from that of combined hepatocellular and cholangiocarcinoma involving the hepatic stem cell or progenitor cell lineages.	22516245
Acute leukemia	Stem Cell Exhaustion	Our results indicate that DDR is a rate-limiting event for acquisition of stem cell-like properties in MLL-ENL-ERtm-mediated transformation, as experimental inhibition of the barrier accelerated the transition to immature cell states and acute leukemia development.	22516260
BCR-ABL Fusion Gene, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Compared with imatinib, nilotinib is a potent breakpoint cluster region/v-abl Abelson murine leukemia viral oncogene (bcr-abl) kinase inhibitor, and it induces higher rate and rapid complete cytogenetic response (CCyR), yet no clinical data are available regarding its efficacy against chronic myeloid leukemia (CML) stem cells.	22517301
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Evaluation of residual CD34(+) Ph(+) progenitor cells in chronic myeloid leukemia patients who have complete cytogenetic response during first-line nilotinib therapy.	22517301
Myocardial necrosis	Stem Cell Exhaustion	Remote ischemic preconditioning immediately before percutaneous coronary intervention does not impact myocardial necrosis, inflammatory response, and circulating endothelial progenitor cell counts: a single center randomized sham controlled trial.	22517646
Infection	Stem Cell Exhaustion	The main factors associated with deteriorating quality of life over time were found to be significant infections, female gender and transplantation with stem cells from a sibling donor.	22519415
Leukemia, Myelocytic, Acute, Acute leukemia	Stem Cell Exhaustion	Bone marrow or peripheral blood stem cell transplantation from unrelated donors in adult patients with acute myeloid leukaemia, an Acute Leukaemia Working Party analysis in 2262 patients.	22519980
Graft-vs-Host Disease, Acute GVH disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	The incidence of acute graft-versus-host disease (GVHD) was similar, but there was more chronic GVHD in the blood stem cell group [hazard ratio (HR) = 1.29, P = 0.02].	22519980
Li-Fraumeni Syndrome, leukemia	Stem Cell Exhaustion	In patients with advanced leukaemia, the blood stem cell group had reduced NRM and improved LFS.	22519980
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In a retrospective registry analysis, we compared the use of blood stem cells (n = 1502) and BM (n = 760) from unrelated donors in patients aged 18-60 years with acute myeloid leukaemia (AML) undergoing myeloablative conditioning between 1997 and 2008.	22519980
Li-Fraumeni Syndrome, leukemia	Stem Cell Exhaustion	In patients with advanced leukaemia, NRM was lower (HR = 0.61, P = 0.02) and LFS was prolonged (HR = 0.67, P = 0.002) when blood stem cells were used.	22519980
Li-Fraumeni Syndrome, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Blood stem cells compared with BM in MUD transplantation for patients with AML in remission resulted in the same rates of LFS.	22519980
Heart failure	Stem Cell Exhaustion	Monocyte-derived and CD34+/KDR+ endothelial progenitor cells in heart failure.	22519984
Heart failure	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) are known to be altered in heart failure (HF), but monocyte-derived EPCs in HF have not been assessed.	22519984
Diabetes	Stem Cell Exhaustion	Downregulation of microRNA-126 in endothelial progenitor cells from diabetes patients, impairs their functional properties, via target gene Spred-1.	22525256
Dominica, Diabetes Mellitus	Stem Cell Exhaustion	Diabetes mellitus (DM) adversely affects the number and function of circulating endothelial progenitor cells (EPCs).	22525256
Acute myocardial infarction	Stem Cell Exhaustion	A potent soluble epoxide hydrolase inhibitor, t-AUCB, acts through PPARg to modulate the function of endothelial progenitor cells from patients with acute myocardial infarction.	22525341
Acute myocardial infarction	Stem Cell Exhaustion	In this work, we investigated whether increasing EETs with the sEH inhibitor t-AUCB would increase angiogenesis related function in endothelial progenitor cells (EPCs) from patients with acute myocardial infarction (AMI).	22525341
Fatigue, Sarcopenia	Stem Cell Exhaustion	Prevalence of sarcopenia and relevance of body composition, physiological function, fatigue, and health-related quality of life in patients before allogeneic hematopoietic stem cell transplantation.	22526152
Sarcopenia	Stem Cell Exhaustion	We believe that allogeneic hematopoietic stem cell transplant (allo-HSCT) patients often exhibit sarcopenia prior to transplantation.	22526152
Structure of suprasellar region, Pituitary Adenoma	Stem Cell Exhaustion	Moreover, in the present case, the suprasellar tumor remained visible after autologous peripheral stem cell transplant, likely due to the residual pituitary adenoma.	22527852
Fracture	Stem Cell Exhaustion	Significance of circulating endothelial progenitor cells in patients with fracture healing process.	22528744
Childhood Breast Carcinoma	Stem Cell Exhaustion	Some of the induced pluripotent stem cell (iPS cell)-inducing factors have been reported to be expressed in breast cancer.	22528804
Malignant neoplasm of lung, Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	The increasing relevance of the cancer stem cell (CSC) hypothesis and the impact of CSC-associated markers in the carcinogenesis of solid tumours may provide potential prognostic implications in lung cancer.	22529186
Neoplasms	Stem Cell Exhaustion	In this study we tested the prevalence, histoanatomical distribution and tumour biological significance of the Wnt target protein and cancer stem cell marker LGR5 in tumours of the human gastrointestinal tract.	22530031
Parainfluenza Virus Infections	Stem Cell Exhaustion	Human parainfluenza virus infection after hematopoietic stem cell transplantation: risk factors, management, mortality, and changes over time.	22531491
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Criteria for good candidate antigens for immunotherapy of acute myeloid leukemia are high expression on leukemic stem cells in the majority of patients with acute myeloid leukemia and low or no expression in vital tissues.	22532518
Autoimmune Diseases	Stem Cell Exhaustion	Haematopoietic stem cell transplantation (HSCT) in severe autoimmune diseases: analysis of UK outcomes from the British Society of Blood and Marrow Transplantation (BSBMT) data registry 1997-2009.	22533715
Autoimmune Diseases	Stem Cell Exhaustion	The British Society of Blood and Marrow Transplantation Data Registry was used to analyse outcomes of haematopoietic stem cell transplantation (HSCT) in severe autoimmune diseases (SADs) from 1997 to 2009.	22533715
Cerebrovascular accident	Stem Cell Exhaustion	Therapeutic effects of human adipose stem cell-conditioned medium on stroke.	22535477
Cerebrovascular accident	Stem Cell Exhaustion	Stem cell therapy is a promising approach for stroke.	22535477
Concomitant Medication Submission Domain	Stem Cell Exhaustion	The use of stem cell-conditioned medium (CM) may be a feasible approach to overcome these limitations.	22535477
Concomitant Medication Submission Domain	Stem Cell Exhaustion	Especially, specific stem cell culture condition and continuous infusion of CM into ischemic brains would have better therapeutic results.	22535477
Concomitant Medication Submission Domain	Stem Cell Exhaustion	The CM was prepared by culturing human adipose-derived stem cells in a three-dimensional spheroid form to increase the secretion of angiogenic/neuroprotective factors.	22535477
Multiple Myeloma	Stem Cell Exhaustion	Increment of hematopoietic progenitor cell count as an indicator of efficient autologs stem cell harvest in patients with multiple myeloma.	22535685
Microalbuminuria, Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Specifically, some differentially expressed proteins were verified by MRM in urine from normoalbuminuric and microalbuminuric patients with type 2 diabetes, wherein alpha-1-antitrypsin, alpha-1-acid glycoprotein 1, and prostate stem cell antigen had excellent AUC values (0.849, 0.873, and 0.825, resp.).	22536212
Hematopoietic Stem Cell Mobilization	Stem Cell Exhaustion	Plerixafor, when used pre-emptively in addition to chemomobilization, seems to mobilize more primitive CD34(+) stem cells, T lymphocytes, and NK cells.	22536949
Keratitis caused by infection	Stem Cell Exhaustion	Infectious keratitis in severe limbal stem cell deficiency: characteristics and risk factors.	22537286
Keratitis caused by infection	Stem Cell Exhaustion	To evaluate the incidence, clinical and microbiological characteristics and risk factors of infectious keratitis in patients with limbal stem cell deficiency (LSCD).	22537286
Multiple Myeloma	Stem Cell Exhaustion	Impact of MiRSNPs on survival and progression in patients with multiple myeloma undergoing autologous stem cell transplantation.	22539802
Multiple Myeloma	Stem Cell Exhaustion	One hundred and thirty-seven patients with chemosensitive multiple myeloma (73M/64F) intensified with autologous stem cell transplantation (ASCT) were studied.	22539802
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	High-dose melphalan (HD-Mel) is considered the current standard of care among the preparative regimens used in autologous peripheral blood stem cell transplantation (SCT) for multiple myeloma (MM), but optimal time and schedule of administration is not defined.	22540279
Multiple Myeloma	Stem Cell Exhaustion	Effect of time to infusion of autologous stem cells (24 vs. 48 h) after high-dose melphalan in patients with multiple myeloma.	22540279
Toxic effect	Stem Cell Exhaustion	We retrospectively analyzed outcomes and toxicities of HD-Mel administered on day -2 vs. day -1 before autologous stem cells infusion.	22540279
Hypernatremia	Stem Cell Exhaustion	Iron overload in allogeneic hematopoietic stem cell transplant recipients.	22540302
Failure	Stem Cell Exhaustion	Failure in mobilization of peripheral blood (PB) stem cells is a frequent reason for not performing hematopoietic stem cell transplantation (HSCT).	22540329
Serous	Stem Cell Exhaustion	In addition, a more broadly distributed array of gene alterations has been discovered in the oviduct, manifested as secretory (or stem) cell outgrowths that are increased in frequency as a function of older age and serous cancer status.	22543918
Multiple Myeloma	Stem Cell Exhaustion	Diagnostic performance of whole-body MRI for the detection of persistent or relapsing disease in multiple myeloma after stem cell transplantation.	22544292
Multiple Myeloma	Stem Cell Exhaustion	To compare the diagnostic performance of whole-body MRI (WBMRI) with haematological parameters for detecting persistent or relapsing disease in patients with multiple myeloma after stem cell transplantation.	22544292
Multiple Myeloma	Stem Cell Exhaustion	Sixty-six WBMRI acquisitions were performed in 33 patients with multiple myeloma at two time points after stem cell transplantation.	22544292
Sarcoma, Myeloid	Stem Cell Exhaustion	WBMRI allows the detection and exact localisation of intra- and extramedullary myeloma manifestations after stem cell transplantation, but shows only moderate agreement with routinely performed laboratory tests for determination of remission.	22544292
Acute leukemia	Stem Cell Exhaustion	Second allogeneic transplantation for relapsed acute leukemia after initial allogeneic hematopoietic stem cell transplantation.	22544355
Acute leukemia	Stem Cell Exhaustion	We retrospectively reviewed the medical records of 45 patients with relapsed acute leukemia after initial allogeneic hematopoietic stem cell transplantation (allo-HSCT).	22544355
Cerebral Hemorrhage	Stem Cell Exhaustion	Human adipose-derived stem cells for the treatment of intracerebral hemorrhage in rats via femoral intravenous injection.	22544763
Cytomegalovirus Infections	Stem Cell Exhaustion	Initial low-dose valganciclovir as a preemptive therapy is effective for cytomegalovirus infection in allogeneic hematopoietic stem cell transplant recipients.	22547196
Cytomegalovirus Infections, Communicable Diseases, allogeneic hematopoietic stem cell transplant with purging	Stem Cell Exhaustion	Preemptive therapy for cytomegalovirus (CMV) infection in allogeneic hematopoietic stem cell transplant (HSCT) patients is effective in decreasing the incidence of CMV disease.	22547196
Arterial Injury	Stem Cell Exhaustion	Aging is associated with dysfunction of endothelial progenitor cells (EPCs), and shear stress has a beneficial impact on EPC function; however, the effects of aging and shear stress on the endothelial repair capacity of EPCs after arterial injury have not been reported.	22547440
Hodgkin Disease	Stem Cell Exhaustion	Panobinostat in patients with relapsed/refractory Hodgkin's lymphoma after autologous stem-cell transplantation: results of a phase II study.	22547596
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	Hodgkin's lymphoma (HL) has no standard of care for patients who are relapsed or refractory to autologous stem-cell transplantation (ASCT).	22547596
Richters syndrome", Chronic Lymphocytic Leukemia, Chronic leukemia (category)	Stem Cell Exhaustion	Autologous and allogeneic stem-cell transplantation for transformed chronic lymphocytic leukemia (Richter's syndrome): A retrospective analysis from the chronic lymphocytic leukemia subcommittee of the chronic leukemia working party and lymphoma working party of the European Group for Blood and Marrow Transplantation.	22547610
REG1CP gene	Stem Cell Exhaustion	The aim of this study was to evaluate the outcome after autologous stem-cell transplantation (autoSCT) or allogeneic stem-cell transplantation (alloSCT) in RS.	22547610
Acute myocardial infarction	Stem Cell Exhaustion	Mobilization of CD34+CXCR4+ stem/progenitor cells and the parameters of left ventricular function and remodeling in 1-year follow-up of patients with acute myocardial infarction.	22547906
Medulloblastoma	Stem Cell Exhaustion	Recurrent anaplastic medulloblastoma in cerebrospinal fluid after autologous hematopoietic stem cell transplant.	22550044
Medulloblastoma	Stem Cell Exhaustion	Herein, we report the CSF cytologic features of a case of recurrent anaplastic medulloblastoma in a 17-year-old male patient who had undergone autologous hematopoietic stem cell transplant as a part of the treatment protocol.	22550044
Carcinoma, Medulloblastoma	Stem Cell Exhaustion	The differential diagnosis of anaplastic medulloblastoma is broader than that of classic medulloblastoma, as it includes metastatic carcinomas and large cell lymphoma, a differential diagnosis especially pertinent in this patient with a history of autologous hematopoietic stem cell transplant.	22550044
Nontuberculous Mycobacteria	Stem Cell Exhaustion	A 5-year-old female patient underwent stem cell/bone marrow transplant with disseminated NTM.	22550970
Neoplasms	Stem Cell Exhaustion	Transcript of CD133 in tumor tissue was lower in patients treated with NSAIDs (0.28 +- 0.07 vs. 0.51 +- 0.08; p<0.03) as well as some other stem cell-related transcripts.	22552364
Malignant tumor of colon	Stem Cell Exhaustion	Our results show that short-term preoperative NSAID treatment downregulates colon cancer tissue expression of Prominin 1/CD133, a stem cell marker indicative of survival prognosis as confirmed.	22552364
Post-transplant acute limbic encephalitis	Stem Cell Exhaustion	Human herpesvirus 6 (HHV6) is the major cause of posttransplant acute limbic encephalitis (PALE) in immunosuppressed patients following hematopoietic stem cell transplant.	22554258
Adult Glioblastoma	Stem Cell Exhaustion	Human mesenchymal stem cells exploit the immune response mediating chemokines to impact the phenotype of glioblastoma.	22554389
Malignant Neoplasms	Stem Cell Exhaustion	Given this, our primary aim was to ascertain immunohistochemical expression of the ABC transporters ABCB5 and ABCF2 and, the stem cell marker, nestin in a spectrum of benign and malignant nevomelanocytic proliferations, including nevi (n=30), in situ (n=31) and invasive (n=24) primary cutaneous melanomas to assess their role in the stepwise development of malignancy.	22555176
melanoma	Stem Cell Exhaustion	Profiling of ABC transporters ABCB5, ABCF2 and nestin-positive stem cells in nevi, in situ and invasive melanoma.	22555176
Adult Glioblastoma, Specialty Type - cancer	Stem Cell Exhaustion	Can irradiation of potential cancer stem-cell niche in the subventricular zone influence survival in patients with newly diagnosed glioblastoma?	22555992
Adult Glioblastoma	Stem Cell Exhaustion	Glioblastoma progenitor or stem cells residing in the stem-cell niche in the subventricular zones (SVZ) can initiate or promote tumorigenesis.	22555992
Specialty Type - cancer	Stem Cell Exhaustion	Irradiation of potential cancer stem-cell niche in the SVZ may influence survival.	22555992
Adult Glioblastoma, Specialty Type - cancer	Stem Cell Exhaustion	Irradiation of potential cancer stem-cell niche influences survival outcomes in patients with newly diagnosed glioblastoma.	22555992
Adenoma, Colorectal Carcinoma	Stem Cell Exhaustion	Associations between markers of colorectal cancer stem cells and adenomas among ethnic groups.	22562538
Burn injury	Stem Cell Exhaustion	Analysis of attitudes toward the source of progenitor cells in tissue-engineered products for use in burns compared with other disease states.	22564226
Burn, CTCAE	Stem Cell Exhaustion	The first trials using progenitor cells to improve burn wound healing are beginning.	22564226
Diabetes, Burn injury, Parkinson Disease	Stem Cell Exhaustion	Levels of acceptance for the use of progenitor cells derived from these sources for treatment across a range of disease states (burns, Parkinson's disease, diabetes, and for cosmetic use) were also assessed.	22564226
Post-transplant acute limbic encephalitis	Stem Cell Exhaustion	Human herpesvirus-6 (HHV-6) frequently reactivates after allogeneic hematopoietic stem cell transplantation (HSCT); its most severe manifestation is the syndrome of posttransplantation acute limbic encephalitis (HHV-6-PALE).	22564265
Hodgkin Disease	Stem Cell Exhaustion	The case of a 29-year-old female patient is presented who obtained polychemotherapy and allogenic stem cell transplantation following the diagnosis of classical Hodgkin's disease.	22564287
Injury of kidney	Stem Cell Exhaustion	Delayed treatment with human umbilical cord blood-derived stem cells attenuates diabetic renal injury.	22564642
Ewings sarcoma	Stem Cell Exhaustion	Plerixafor plus G-CSF in combination with chemotherapy for stem cell mobilization in a pediatric patient with Ewing's sarcoma.	22566276
Malignant Neoplasms	Stem Cell Exhaustion	Some malignant tumors in childhood require high-dose chemotherapy with stem cell support to achieve a cure.	22566276
Ewings sarcoma, Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Based on the experience with lymphoma and myeloma patients in whom peripheral blood-derived stem cell (PBSC) collection following mobilization with G-CSF failed, we successfully employed plerixafor in a 14-year-old female diagnosed with Ewing's sarcoma in early relapse treated with three lines of chemotherapy in whom PBSC could not be mobilized using either G-CSF alone or G-CSF following chemotherapy.	22566276
Neoplasms	Stem Cell Exhaustion	Plerixafor may be an effective and safe agent for stem cell collection in pediatric patients with solid tumors, although new studies addressed to evaluate its effectiveness and safety are needed.	22566276
Multiple Myeloma	Stem Cell Exhaustion	Lenalidomide after stem-cell transplantation for multiple myeloma.	22571201
Multiple Myeloma	Stem Cell Exhaustion	Data are lacking on whether lenalidomide maintenance therapy prolongs the time to disease progression after autologous hematopoietic stem-cell transplantation in patients with multiple myeloma.	22571201
Toxic effect, Malignant Neoplasms, Multiple Myeloma	Stem Cell Exhaustion	Lenalidomide maintenance therapy, initiated at day 100 after hematopoietic stem-cell transplantation, was associated with more toxicity and second cancers but a significantly longer time to disease progression and significantly improved overall survival among patients with myeloma.	22571201
Multiple Myeloma	Stem Cell Exhaustion	Lenalidomide maintenance after stem-cell transplantation for multiple myeloma.	22571202
Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy with autologous stem-cell transplantation is a standard treatment for young patients with multiple myeloma.	22571202
Cerebrovascular accident	Stem Cell Exhaustion	Societal value of stem cell therapy in stroke--a modeling study.	22571941
Cerebrovascular accident	Stem Cell Exhaustion	Stem cell therapy (SCT) may promote functional recovery also in stroke patients, thereby improving quality of life and reducing costs.	22571941
Cerebrovascular accident	Stem Cell Exhaustion	We modeled for age (55, 65, and 75 years), functional status at discharge (mRS 2, 3, and 4), effectiveness of SCT (50 and 25% increase in the probability to improve 1 mRS grade), mode of stem cell administration, risk of recurrent stroke, complications of intervention, and use of immunosuppressive drugs.	22571941
Cerebrovascular accident	Stem Cell Exhaustion	The application of the health-economic model to Sweden shows that in younger stroke patients with moderate disability, the societal value of SCT given a zero price of stem cells is 166,500 USD.	22571941
Cerebrovascular accident	Stem Cell Exhaustion	Hence, further research and development in stem cells suitable for stroke therapy could potentially produce great value to society.	22571941
Hypertension, CTCAE	Stem Cell Exhaustion	An increased number of endothelial progenitor cells (EPCs), which correlated with heme oxygenase-1 gene expression and nitric oxide-mediated vasodilation [flow-mediated dilation (FMD)], has been recently reported by us in Bartter/Gitelman syndromes, rare diseases that represent a human model of endogenous angiotensin (Ang) II type-1 receptor antagonism and depicting an opposite picture of hypertension.	22573121
Exfoliative dermatitis, Fever, Mantle cell lymphoma	Stem Cell Exhaustion	A 56-year-old patient presented progressive erythroderma and fever occurring after autologous hematopoietic stem-cell transplantation for mantle cell lymphoma.	22576078
Chronic myeloproliferative disorder	Stem Cell Exhaustion	Allogeneic stem cell transplantation for myeloproliferative neoplasm in blast phase.	22578777
Hematologic Neoplasms, Immunocompromised Host	Stem Cell Exhaustion	Immunocompromised patients with hematological malignancies and/or recipients of hematopoietic stem cell transplants are constantly exposed to several fungal, bacterial, and viral respiratory pathogens.	22580034
Specialty Type - cancer, Aggressive course, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Nestin expression reportedly correlates with aggressive growth, metastasis, poor prognosis and presence of cancer stem cells (CSCs) in various tumors.	22580387
Lymphoma	Stem Cell Exhaustion	Defects in lymphocyte subsets and serological memory persist a median of 10 years after high-dose therapy and autologous progenitor cell rescue for malignant lymphoma.	22580768
Primary central nervous system lymphoma, Primary intraocular non-Hodgkin malignant lymphoma	Stem Cell Exhaustion	Intensive chemotherapy with thiotepa, busulfan and cyclophosphamide and hematopoietic stem cell rescue in relapsed or refractory primary central nervous system lymphoma and intraocular lymphoma: a retrospective study of 79 cases.	22581000
Primary central nervous system lymphoma, Primary intraocular non-Hodgkin malignant lymphoma	Stem Cell Exhaustion	We report the results of a large multicenter retrospective analysis of intensive chemotherapy followed by hematopoietic stem cell rescue in immunocompetent adult patients with primary central nervous system lymphoma or intraocular lymphoma after the failure of high-dose methotrexate-based treatment.	22581000
Unresponsive to Treatment	Stem Cell Exhaustion	The role of intensive chemotherapy followed by hematopoietic stem cell rescue in chemorefractory patients needs to be more accurately defined.	22581000
Aplasia Cutis Congenita, Adenoid Cystic Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Adenoid cystic carcinoma (ACC) cells with a high level of ALDH1, a known cancer stem cell (CSC) marker, had higher tumorigenic, invasive, and metastatic abilities.	22581680
Coronary Arteriosclerosis	Stem Cell Exhaustion	The CD34+ hematopoetic stem cell has shown significant promise in addressing myocardial ischemia by promoting angiogenesis that helps preserve the functionality of ischemic myocardium.	22581926
Degenerative polyarthritis	Stem Cell Exhaustion	Infrapatellar fat pad-derived mesenchymal stem cell therapy for knee osteoarthritis.	22583627
Degenerative polyarthritis	Stem Cell Exhaustion	Twenty five stem cell injections combined with arthroscopic debridement were administered to patients with knee OA.	22583627
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	This prospective multicenter phase III study compared the efficacy and safety of a triple combination (bortezomib-thalidomide-dexamethasone [VTD]) versus a dual combination (thalidomide-dexamethasone [TD]) in patients with multiple myeloma (MM) progressing or relapsing after autologous stem-cell transplantation (ASCT).	22585692
Lymphoma, Follicular	Stem Cell Exhaustion	In 2008, we reported favorable 5-year outcomes of nonmyeloablative allogeneic stem cell transplantation after fludarabine, cyclophosphamide, rituximab (FCR) conditioning for relapsed and chemosensitive follicular lymphoma.	22586182
Colitis, Ischemic	Stem Cell Exhaustion	Adipose-derived stem cells on the healing of ischemic colitis: a therapeutic effect by angiogenesis.	22588671
Colitis	Stem Cell Exhaustion	We verified the effects of adipose-derived stem cells (ASCs) on ischemia-induced colitis in a rat model.	22588671
Malignant Neoplasms, Communicable Diseases	Stem Cell Exhaustion	Other factors associated with in-hospital mortality were severity of illness, performance status, hematologic malignancy, stem-cell transplantation, presence of three or more abnormal physiological variables, time from derangement to ICU admission, presence of infection, need for mechanical ventilation and vasopressor, and low PaO(2)/FiO(2) ratio.	22592633
Impaired, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Extramedullary (EM) organ impairment in patients with multiple myeloma (MM) is a rare event, occurring mostly during disease relapse after high-dose chemotherapy with autologous or allogeneic stem cell transplantation.	22593484
Colorectal Carcinoma	Stem Cell Exhaustion	Evaluation of the adenocarcinoma-associated gene AGR2 and the intestinal stem cell marker LGR5 as biomarkers in colorectal cancer.	22605983
Neoplasms, Cytogenetic Complete Response	Stem Cell Exhaustion	Our findings indicate that the assessment of AGR2 and LGR5 in PB might reflect the presence of circulating tumor cells (CTC) and stem cell like CTC in CRC.	22605983
Malignant neoplasm of liver	Stem Cell Exhaustion	Gene expression profiling of liver cancer stem cells by RNA-sequencing.	22606345
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Accumulating evidence supports that tumor growth and cancer relapse are driven by cancer stem cells.	22606345
Liver carcinoma, Hollings Cancer Center, Malignant neoplasm of liver	Stem Cell Exhaustion	Our previous work has demonstrated the existence of CD90(+) liver cancer stem cells (CSCs) in hepatocellular carcinoma (HCC).	22606345
Hollings Cancer Center	Stem Cell Exhaustion	The identified genes, such as GPC3 that are distinctly expressed in liver CD90(+)CSCs, may be promising gene candidates for HCC therapy without inducing damages to normal liver stem cells.	22606345
Cerebral Palsy	Stem Cell Exhaustion	Treatment of one case of cerebral palsy combined with posterior visual pathway injury using autologous bone marrow mesenchymal stem cells.	22607263
Toxoplasmosis	Stem Cell Exhaustion	The diagnosis of Toxoplasma infection or disease in hematopoietic stem cell transplantation (HSCT) patients is achieved mainly by PCR screening; however screening did not find wide field of use in practice due to costly expenditures of PCR.	22609887
Toxoplasmosis	Stem Cell Exhaustion	This study aimed to determine patients at high risk of Toxoplasma infection or disease before transplantation by stem cell originated buffy coat PCR and subsequently to screen them.	22609887
Osteosclerotic Myeloma	Stem Cell Exhaustion	Long-term outcomes after autologous stem cell transplantation for patients with POEMS syndrome (osteosclerotic myeloma): a single-center experience.	22611150
POEMS Syndrome	Stem Cell Exhaustion	Patients with disseminated POEMS can be treated with high-dose therapy and autologous stem cell transplantation (ASCT).	22611150
Anemia, Traumatic AND/OR non-traumatic injury	Stem Cell Exhaustion	To evaluate the roles of apoptotic cells in peripheral blood (PB) on multiple organ injury, five patients with hematopoietic stem cell transplantation (HSCT) and one with refractory anemia were examined.	22612508
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSCs) have recently been defined as a fraction of tumor cells highly resistant to therapy and subsequently considered to be responsible for tumor recurrence.	22614016
Specialty Type - cancer	Stem Cell Exhaustion	It was reported that hypoxic conditions were correlated with cancer stem cell generation and HIF-1a acted as a transcription regulator in nuclear HIF-1a expression.	22614155
Biliary Tract Cancer	Stem Cell Exhaustion	Association of stem cell marker expression pattern and survival in human biliary tract cancer.	22614781
Thrombomodulin Alfa	Stem Cell Exhaustion	The investigated BTC samples showed a low to moderate and partially significantly different expression pattern of the stem cell markers in vitro, in vivo and in TMA.	22614781
Thrombomodulin Alfa, Carcinogenesis	Stem Cell Exhaustion	Hierarchical cluster analysis identified subgroups with homogenous expression of stem cell markers significantly differing with respect to cytokeratin expression in xenografts and Ki67 proliferation marker in human TMA, respectively - thus indicating possible heterogeneous carcinogenesis pathways in BTC.	22614781
Cerebrovascular Disorders	Stem Cell Exhaustion	Circulating mesenchymal stem cells microparticles in patients with cerebrovascular disease.	22615882
Cerebrovascular accident	Stem Cell Exhaustion	Preclinical and clinical studies have shown that the application of CD105(+) mesenchymal stem cells (MSCs) is feasible and may lead to recovery after stroke.	22615882
neurological complication	Stem Cell Exhaustion	* Brain imaging frequently demonstrates neurological complications following haematopoietic stem cell transplantation.	22618523
Brain Injuries	Stem Cell Exhaustion	Human umbilical cord blood mononuclear cells (hUCB-MNCs) are a rich source of various stem cells that could be of interest in repairing perinatal brain damage.	22621245
Acute Coronary Syndrome	Stem Cell Exhaustion	Impact of a cardiac rehabilitation program and inflammatory state on endothelial progenitor cells in acute coronary syndrome patients.	22626841
GDC AJCC Clinical Stage Terminology, Acute Coronary Syndrome	Stem Cell Exhaustion	Among the benefits of a cardiac rehabilitation (CR) program for patients after an acute coronary syndrome (ACS) is the mobilization of endothelial progenitor cells (EPCs).	22626841
Myeloid neoplasm	Stem Cell Exhaustion	Phase II study of dose-modified busulfan by real-time targeting in allogeneic hematopoietic stem cell transplantation for myeloid malignancy.	22631696
physiopathological, Atherosclerosis	Stem Cell Exhaustion	Since risk factors for atherosclerosis accelerate endothelial senescence and impair angiogenesis, we examined the role of Lp(a) in dysfunction and senescence of endothelial progenitor cells (EPC) and endothelial cells.	22634007
Herpesviridae	Stem Cell Exhaustion	Successful clearance of cutaneous acyclovir-resistant, foscarnet-refractory herpes virus lesions with topical cidofovir in an allogeneic hematopoietic stem cell transplant patient.	22635417
Herpes Simplex Infections, Ulcer	Stem Cell Exhaustion	Here, we present a case of a successful clearance of a perianal acyclovir resistant and foscarnet refractory herpes simplex virus (HSV1) ulcer in a 34 year-old woman who had undergone allogeneic hematopoietic stem cell transplantation.	22635417
Colorectal Carcinoma	Stem Cell Exhaustion	In situ validation of an intestinal stem cell signature in colorectal cancer.	22637696
Adenoma	Stem Cell Exhaustion	Wnt/Tcf, Lgr5, Ascl2 and/or Bmi1 signalling is believed to define the mouse intestinal stem cell niche(s) from which adenomas arise.	22637696
Colorectal Carcinoma	Stem Cell Exhaustion	The aim of this study was to determine the relevance of these putative intestinal stem cell markers to human colorectal cancer.	22637696
Aggressive behavior, Specialty Type - cancer	Stem Cell Exhaustion	In this large series, Lgr5 expression is not associated with increased tumour aggressiveness, as might be expected from a cancer stem cell marker.	22637696
Colorectal Carcinoma	Stem Cell Exhaustion	These data suggest that 74-85% of colorectal cancers express a Lgr5/Ascl2 associated signature and support the hypothesis that they derive from Lgr5(+)/Ascl2(+) crypt stem cells, not Bmi1(+) stem cells.	22637696
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Allogeneic haematopoietic stem cell transplantation for chronic lymphocytic leukaemia: outcome in a 20-year cohort.	22640008
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	The curative potential of allogeneic haematopoietic stem cell transplant (allo HSCT) in chronic lymphocytic leukaemia CLL is established, with a demonstrated role for graft-versus-leukaemia and less certainty for other factors in determining outcome.	22640008
Mantle cell lymphoma	Stem Cell Exhaustion	Nordic MCL2 trial update: six-year follow-up after intensive immunochemotherapy for untreated mantle cell lymphoma followed by BEAM or BEAC + autologous stem-cell support: still very long survival but late relapses do occur.	22640180
Lymphoma	Stem Cell Exhaustion	In 2008 we reported the early - based on the median observation time of 4 years - results of the Nordic Lymphoma Group MCL2 study of frontline intensive induction immunochemotherapy and autologous stem cell transplantation (ASCT), with more than 60% event-free survival at 5 years, and no subsequent relapses reported.	22640180
Chronic Kidney Diseases, Chronic Kidney Disease, CTCAE	Stem Cell Exhaustion	Stem cell (SC) therapy for chronic kidney disease (CKD) is urgently needed.	22640266
Chronic Kidney Diseases	Stem Cell Exhaustion	Mesenchymal stem cells therapy is a potential therapeutic modality for early phases of CKD.	22640266
Ischemic stroke	Stem Cell Exhaustion	Increased levels of circulating endothelial progenitor cells in patients with ischaemic stroke treated with statins during acute phase.	22640405
Ischemic stroke	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) have been suggested to be a therapeutic option in ischaemic stroke.	22640405
Acute myocardial infarction	Stem Cell Exhaustion	The early- to mid-term impact of bone-marrow-derived stem cells (BMC) on diastolic function and exercise capacity after acute myocardial infarction (AMI) remains controversial.	22640927
Lymphoma, Follicular	Stem Cell Exhaustion	Comparison of outcomes after allogeneic hematopoietic stem cell transplantation in patients with follicular lymphoma, diffuse large B-cell lymphoma associated with follicular lymphoma, or de novo diffuse large B-cell lymphoma.	22641292
Lymphoma, Follicular, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	The outcome after allogeneic hematopoietic stem cell transplantation (allo-HCT) for diffuse large B-cell lymphoma (DLBCL) associated with follicular lymphoma (FL), which includes DLBCL with pre- or co-existing FL, remains controversial, and few previous reports have compared the outcomes after allo-HCT for FL, DLBCL associated with FL, and de novo DLBCL.	22641292
Hemorrhagic cystitis	Stem Cell Exhaustion	Low incidence of adenovirus hemorrhagic cystitis following autologous hematopoietic stem cell transplantation in the rituximab era.	22641349
Osteoporotic Fractures	Stem Cell Exhaustion	To determine whether estrogen regulates mesenchymal stem cell (MSC) activity in bone marrow from osteoporotic postmenopausal women.	22642912
Muscle satellite cell	Stem Cell Exhaustion	Can a young muscle's stem cell secretome prolong our lives?	22643017
Progeria	Stem Cell Exhaustion	A recent provocative study on muscle stem cells, in a mouse model of human progeria, proposes a mechanism that might provide answers to these fundamental ageing questions.	22643017
Malignant Neoplasms	Stem Cell Exhaustion	High-dose infusional gemcitabine combined with busulfan and melphalan with autologous stem-cell transplantation in patients with refractory lymphoid malignancies.	22643322
Graft-vs-Host Disease, Acute GVH disease, Infection	Stem Cell Exhaustion	Infections and acute graft-versus-host disease (GvHD) represent major complications of allogeneic stem-cell transplantation (SCT).	22643330
Chronic heart failure	Stem Cell Exhaustion	Positive effect of eplerenone treatment on endothelial progenitor cells in patients with chronic heart failure.	22645059
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Survivin is highly expressed in CD34(+)38(-) leukemic stem/progenitor cells and predicts poor clinical outcomes in AML.	22645176
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	To better understand its role in acute myeloid leukemia (AML), we profiled survivin expression in samples obtained from 511 newly diagnosed AML patients and in CD34(+)38(-) AML stem/progenitor cells using a validated reverse-phase protein array; we correlated its levels with clinical outcomes and with levels of other proteins in the same sample set.	22645176
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Importantly, survivin levels were significantly higher in CD34(+)38(-) AML stem/progenitor cells than in bulk blasts and total CD34(+) AML cells (P < .05).	22645176
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	These results suggest that survivin is a prognostic biomarker in AML and that survivin, which is overexpressed in AML stem/progenitor cells, remains a potentially important target for leukemia therapy.	22645176
Coronary Arteriosclerosis	Stem Cell Exhaustion	[Quality of life in patients with coronary artery disease after stem cell therapy].	22645909
Hematologic Neoplasms	Stem Cell Exhaustion	Among them, 65 had hematologic malignancies (including 14 hematopoietic stem cell transplant recipients), 22 had iatrogenic immunosuppression, and 13 had solid malignancies.	22647492
Endometrial Carcinoma, Endometriosis	Stem Cell Exhaustion	These results demonstrate an increased expression of IPO13 in endometriosis and endometrial carcinoma, which could be involved in the pathogenesis of endometriosis and endometrial carcinoma; IPO13 can serve as an endometrial progenitor/stem cell marker.	22648251
Carcinogenesis	Stem Cell Exhaustion	Some authors have found that p53 has a pivotal role in driving the maturation of myeloid stem cells and p53 is, also, involved in colon carcinogenesis.	22648549
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Type 2 diabetes mellitus is associated with an imbalance in circulating endothelial and smooth muscle progenitor cell numbers.	22648662
diabetic	Stem Cell Exhaustion	The CAC/SMPC ratio of in vitro cultured progenitor cells was reduced 2.3-fold in samples from diabetic patients (p < 0.001).	22648662
Renal Cell Carcinoma	Stem Cell Exhaustion	Stem cell markers aldehyde dehydrogenase type 1 and nestin expressions in renal cell cancer.	22649953
Renal Cell Carcinoma Pathway, Refractory Cytopenia of Childhood	Stem Cell Exhaustion	To identify stem cell markers aldehyde dehydrogenase type 1 (ALDH-1) and nestin expression in renal cell carcinoma (RCC).	22649953
Secondary Neoplasm, Refractory Cytopenia of Childhood	Stem Cell Exhaustion	There is a need to perform more studies about stem cell markers in RCC with more patients and in these future studies lymph node metastasis, distant organ metastasis and survival rates should be included.	22649953
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Mobilized peripheral blood stem cells compared with bone marrow from HLA-identical siblings for reduced-intensity conditioning transplantation in acute myeloid leukemia in complete remission: a retrospective analysis from the Acute Leukemia Working Party of EBMT.	22650267
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We used the European Group for Blood and Marrow Transplantation (EBMT) ALWP data to compare the outcome of mobilized peripheral blood stem cells (PBSC) (n = 1430) vs. bone marrow (BM) (n = 107) for acute myelogenous leukemia (AML) patients with complete remission that underwent RIC-alloSCT from compatible sibling donors.	22650267
palladium	Stem Cell Exhaustion	substantia nigra, "SN") and are able to differentiate into both glia and neurons, but only under particular growth conditions including co-culturing with embryonic stem cell-derived neural precursors ("ESNPs"); this suggests that PD multipotent neural stem/progenitor cells do reside within the SN and other areas, but by themselves appear to lack key factors required for neuronal differentiation.	22652067
Parkinsonian Disorders	Stem Cell Exhaustion	Neurogenic potential of progenitor cells isolated from postmortem human Parkinsonian brains.	22652067
palladium, Parkinson Disease	Stem Cell Exhaustion	The success of cellular therapies for Parkinson's disease (PD) will depend not only on a conducive growth environment in vivo, but also on the ex vivo amplification and targeted neural differentiation of stem/progenitor cells.	22652067
Unknown (origin) (qualifier value)	Stem Cell Exhaustion	Here, we demonstrate the in vitro proliferative and differentiation potential of stem/progenitor cells, adult human neural progenitor cells ("AHNPs") isolated from idiopathic PD postmortem tissue samples and, to a lesser extent, discarded deep brain stimulation electrodes.	22652067
Neoplasms	Stem Cell Exhaustion	The cell surface marker CD133 has been proposed as a brain tumor stem cell marker.	22652175
Neoplasms	Stem Cell Exhaustion	A distinct subpopulation within CD133 positive brain tumor cells shares characteristics with endothelial progenitor cells.	22652175
Neoplasms	Stem Cell Exhaustion	Our data suggest the presence of a distinct subpopulation of CD133(+) cells isolated from human brain tumors, with characteristics of endothelial progenitor cells (EPCs).	22652175
Neoplasms	Stem Cell Exhaustion	Importantly, by analyzing transformed cells generated in vitro and by characterizing novel transgenic mouse models, we further demonstrate that cooperation between an EMT inducer and an active form of RAS is sufficient to trigger transformation of mammary epithelial cells into malignant cells exhibiting all the characteristic features of claudin-low tumors, including low expression of tight and adherens junction genes, EMT traits, and stem cell-like characteristics.	22654675
COL4A2 wt Allele, Cerebral Hemorrhage	Stem Cell Exhaustion	This study was designed to assess the clinical effect of bone marrow mononuclear cells including mesenchymal stem cell (MSCs) in patients with intracerebral hemorrhage (ICH).	22657095
Cytomegalovirus viremia, Cytomegalovirus Retinitis	Stem Cell Exhaustion	Risk factors for cytomegalovirus retinitis in patients with cytomegalovirus viremia after hematopoietic stem cell transplantation.	22657564
Retinitis, Persistent CMV viremia	Stem Cell Exhaustion	To evaluate the risk factors for cytomegalovirus (CMV) retinitis in patients with CMV viremia after hematopoietic stem cell transplantation (HSCT).	22657564
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	We examined the steady state peripheral blood CD34+ cell count to predict ability to mobilize adequate hematopoietic progenitor cells in 63 myeloma and lymphoma patients.	22658279
Anemia, Sickle Cell	Stem Cell Exhaustion	Stem cell transplant for children with sickle cell anemia: parent and patient interest.	22659467
Anemia, Sickle Cell, Renal carnitine transport defect	Stem Cell Exhaustion	We describe adolescents' and parents' interest in hematopoietic stem cell transplant (HSCT) as a cure for sickle cell disease (SCD) and factors associated with increased interest.	22659467
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Cytogenetic assays demonstrated additional chromosome abnormalities (ACAs): chromosome 8 trisomy in a Ph-negative clone during the IMA treatment (in 1 case) and der(9q) in Ph-positive clone (in 2 cases); in patients receiving first-line IMA only chromosome 8 trisomy was observed which was associated with myelodysplastic syndrome - this was the only case where hematopoietic stem cell transplantation (HSCT) was performed.	22660209
Hematologic Neoplasms, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Since the involvement of stem cells is considered to be important in hematological malignancies as well as normal hematopoiesis, we examined the expression of newly defined HSC factors including HOXB4, TCFEC, HMGB-1, FOS, and SPI-1 in the bone marrow (BM) from de novo acute myeloid leukemia (AML) patients.	22664110
Atherosclerosis, Myocardial Ischemia, Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Decreased endothelial progenitor cells and increased serum glycated albumin are independently correlated with plaque-forming carotid artery atherosclerosis in type 2 diabetes patients without documented ischemic disease.	22664650
Plaque, Atherosclerotic, Myocardial Ischemia, Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	The aim of the present study was to investigate the serum levels of endothelial progenitor cells (EPCs) in type 2 diabetic patients without documented ischemic disease and the association between EPCs and atherosclerotic plaque formation in the carotid artery.	22664650
Abnormality of mitochondrial metabolism	Stem Cell Exhaustion	Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype.	22665934
Chronic graft-versus-host disease	Stem Cell Exhaustion	CD4+CD25highCD127low regulatory T cells in peripheral blood are not an independent factor for chronic graft-versus-host disease after allogeneic stem cell transplantation.	22666141
Multiple Myeloma	Stem Cell Exhaustion	Tandem autologous stem cell transplantation in multiple myeloma after high-dose chemotherapy with two separate collections: single institution experience.	22668021
Toxic effect	Stem Cell Exhaustion	The objective of this analysis was to assess the feasibility and toxicity of tandem autologous stem cell transplantation (T-ASCT) when stem cells were harvested before first and before second transplantation separately.	22668021
Toxic effect	Stem Cell Exhaustion	In conclusion, tandem transplantation with two separate stem cell harvests, performed separately before the each transplantation, is feasible in majority of patients with acceptable toxicity.	22668021
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Flow cytometric quantification and immunophenotyping of leukemic stem cells in acute myeloid leukemia.	22669506
Leukemic Blast Count, Leukemia, Myelocytic, Acute, Pounds	Stem Cell Exhaustion	Leukemic stem cells (LSCs) are root of clonal growth in acute myeloid leukemia (AML) and responsible for the propagation of leukemic blasts (LBs).	22669506
Pounds	Stem Cell Exhaustion	LSCs are considered as CD34 + CD38- population among LBs and often express as CD123, CD44, or CD184, which are rarely expressed on normal hematopoietic stem cells and could be the potential therapeutic targets.	22669506
melanoma, Neoplasms	Stem Cell Exhaustion	It has been suggested recently that stem cell marker expression of jumonji AT-rich interactive domain 1B (JARID1B) is required for continuous tumor growth and maintenance in human cutaneous melanoma cells.	22669717
Uveal melanoma, Specialty Type - cancer	Stem Cell Exhaustion	The aim of this study is to determine whether JARID1B is also expressed in uveal melanoma (UM) and whether JARID1B marks an expanded cancer stem cell pool in poor prognosis UM.	22669717
BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 20	Stem Cell Exhaustion	Since obesity impairs wound healing and bone marrow (BM)-derived vasculogenic progenitor cells (PCs) are important for tissue repair, we hypothesize that obesity-impaired wound healing is due, in part, to impaired PC mobilization, trafficking, and function.	22672117
Specialty Type - cancer, Secondary Neoplasm, Squamous cell carcinoma	Stem Cell Exhaustion	Topoisomerase expression in oral squamous cell carcinoma: relationship with cancer stem cells profiles and lymph node metastasis.	22672768
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	The relationship between predictive proteins and tumors presenting cancer stem cells (CSCs) profiles in oral tumors is still poorly understood.	22672768
Gastrointestinal mucositis	Stem Cell Exhaustion	A pilot randomized controlled trial of an oral care intervention to reduce mucositis severity in stem cell transplant patients.	22672917
Gastrointestinal mucositis	Stem Cell Exhaustion	Oral mucositis remains a significant problem in autologous stem cell transplantation (ASCT).	22672917
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	CD133 has been suggested to be a cancer stem cell (CSC) marker in various types of cancers.	22674531
Kidney Diseases	Stem Cell Exhaustion	Enhanced propagation of adult human renal epithelial progenitor cells to improve cell sourcing for tissue-engineered therapeutic devices for renal diseases.	22674876
Toxic effect	Stem Cell Exhaustion	Treatment in both phases continued until disease progression, stem-cell transplantation, or severe toxicity.	22677155
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Reduced intensity allogeneic hematopoietic stem cell transplantation for MDS using tacrolimus/sirolimus-based GVHD prophylaxis.	22677229
PAFAH1B1 wt Allele	Stem Cell Exhaustion	We report a consecutive series of 59 patients with MDS who underwent reduced-intensity hematopoietic stem cell transplantation (RI-HSCT) with fludarabine/melphalan conditioning and tacrolimus/sirolimus-based GVHD prophylaxis.	22677229
Neurodegenerative Disorders	Stem Cell Exhaustion	Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis.	22681703
Bone marrow hypocellularity, FANCA wt Allele	Stem Cell Exhaustion	FA patients undergo progressive bone marrow failure (BMF) during childhood, which frequently requires allogeneic hematopoietic stem cell transplantation.	22683204
Bone marrow hypocellularity, Fanconi Anemia	Stem Cell Exhaustion	Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells.	22683204
Multiple Myeloma	Stem Cell Exhaustion	Preapheresis peripheral blood (PB) CD34(+) cell count is a strong predictor of hematopoietic stem cell (HSC) mobilization and is routinely used to optimize the timing, cost, and success of HSC collection in patients with multiple myeloma.	22683613
Failure	Stem Cell Exhaustion	However, a uniform PB CD34(+) cell count that predicts mobilization failure has not been defined, resulting in the development of institute-specific algorithms for mobilization, particularly regarding the decision of when to use the novel stem cell mobilization agent plerixafor.	22683613
Multiple Myeloma	Stem Cell Exhaustion	Plerixafor plus granulocyte colony-stimulating factor versus placebo plus granulocyte colony-stimulating factor for mobilization of CD34(+) hematopoietic stem cells in patients with multiple myeloma and low peripheral blood CD34(+) cell count: results of a subset analysis of a randomized trial.	22683613
Neoplasms	Stem Cell Exhaustion	Bone marrow (BM)-derived endothelial progenitor cells (EPCs) play a critical role in tumor vasculogenesis because they provide both instructive (release of pro-angiogenic cytokines, such as VEGF) and structural (vessel incorporation and stabilization) functions.	22683631
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Cardiomyocytes (CMs) and mesenchymal stem cells (MSCs) are important cell types for cardiac repair post myocardial infarction.	22683798
leukemia, Secondary Neoplasm	Stem Cell Exhaustion	Leukemia seems to depend on a small population of "leukemia stem cells (LSCs)" for its growth and metastasis.	22684553
Hepatocarcinogenesis	Stem Cell Exhaustion	The analogy to ageing-related changes is suggestive of premature ageing of stem cells in non-cirrhotic hepatocellular carcinoma-bearing liver as an early step to hepatocarcinogenesis.	22685011
Allogeneic Hematopoietic Stem Cell Transplantation, Pneumonia, Interstitial	Stem Cell Exhaustion	[Successful treatment with prednisolone for air-leak syndrome following interstitial pneumonia after allogeneic hematopoietic stem cell transplantation].	22687980
Varicella Zoster Virus Infection	Stem Cell Exhaustion	[Immune-mediated encephalomyelitis following varicella-zoster virus infection after allogeneic stem cell transplantation].	22687982
Renal dysfunction	Stem Cell Exhaustion	In our facility, three patients developed tacrolimus (TAC)-induced renal dysfunction after allogeneic hemopoietic stem cell transplantation, although trough levels of TAC were within therapeutic ranges.	22687983
Meningioma, Adult Glioblastoma	Stem Cell Exhaustion	Circulating progenitor cells: a comparison of patients with glioblastoma or meningioma.	22688590
Heterogeneity	Stem Cell Exhaustion	SPT shows multi-heterogeneity, which is caused by the disorder in the development of pancreatic stem cell.	22688864
Multiple Myeloma	Stem Cell Exhaustion	Changes in magnetic resonance imaging before and after autologous stem cell transplantation correlate with response and survival in multiple myeloma.	22689673
Multiple Myeloma	Stem Cell Exhaustion	In the current study, we compared treatment response in 100 myeloma patients with changes in infiltration patterns in whole body magnetic resonance imaging before and after autologous stem cell transplantation.	22689673
T-cell leukemia-lymphoma gene	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia-lymphoma with special emphasis on preconditioning regimen: a nationwide retrospective study.	22689862
TRPV6 wt Allele	Stem Cell Exhaustion	We performed a nationwide retrospective study of allogeneic hematopoietic stem cell transplantation (HSCT) for ATL in Japan, with special emphasis on the effects of the preconditioning regimen.	22689862
Intimal sarcoma	Stem Cell Exhaustion	RUNX-1 and CD44 as markers of resident stem cell derivation in undifferentiated intimal sarcoma of pulmonary artery.	22690828
Neoplasms	Stem Cell Exhaustion	These findings, together with the negativity for mature endothelial and smooth muscle markers, raise the question of whether this neoplasm may derive from a vessel wall-resident stem cell, such as the haemangioblast or an embryonic-like stem cell.	22690828
Pulmonary Sclerosing Hemangioma	Stem Cell Exhaustion	Expression and significance of stem cell markers in pulmonary sclerosing haemangioma.	22691172
Herpes encephalitis, Memory Loss, Drowsiness	Stem Cell Exhaustion	A 50-year-old woman developed a human herpes virus 6 limbic encephalitis characterized by memory loss and somnolence, 3 weeks after a cord blood-derived stem cell transplantation.	22691524
Neoplasms, Specialty Type - cancer, leukemia	Stem Cell Exhaustion	Various aspects were highlighted, including the identification of effective therapeutic targets, the role of cellular senescence in tumor development and therapy, chromosome translocations in leukemias and solid tumors, mechanisms underlying fragile sites and chromosome instability, tumor-associated 'omics' landscapes, genetic and epidemiologic risk factors, the role of tissue and cancer stem cells, angiogenesis and the tumor micro-environment, and the epigenetics of cancer.	22692945
Enterococcus	Stem Cell Exhaustion	Enterococcal bacteremia is associated with increased risk of mortality in recipients of allogeneic hematopoietic stem cell transplantation.	22693346
Kidney Diseases	Stem Cell Exhaustion	Mesenchymal stem cells derived from adipose tissue are not affected by renal disease.	22695328
Kidney Diseases	Stem Cell Exhaustion	Mesenchymal stem cells are a potential therapeutic agent in renal disease and kidney transplantation.	22695328
Kidney Diseases	Stem Cell Exhaustion	Autologous cell use in kidney transplantation is preferred to avoid anti-HLA reactivity; however, the influence of renal disease on mesenchymal stem cells is unknown.	22695328
Kidney Diseases, Functional Laterality	Stem Cell Exhaustion	Thus, mesenchymal stem cells of patients with renal disease have similar characteristics and functionality as those from healthy controls.	22695328
Graft-vs-Host Disease, leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European group for blood and marrow transplantation.	22699419
Graft-vs-Host Disease, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This report investigated the impact of graft-versus-host disease (GVHD) on transplantation outcomes in 1859 acute myeloid leukemia patients given allogeneic peripheral blood stem cells after reduced-intensity conditioning (RIC allo-SCT).	22699419
Granulocytic Sarcoma, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation for adult AML patients with granulocytic sarcoma.	22699453
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Therefore, the aim of this study was to assess the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for the management of AML with GS.	22699453
Stable chronic Graft vs Host Disease	Stem Cell Exhaustion	Chronic graft-vs.-host disease (cGVHD) is a complication of allogeneic hematopoietic stem cell transplantation (alloHSCT).	22699667
Toxic effect	Stem Cell Exhaustion	NCA (131)I-MIBG with autologous peripheral blood stem cell transplantation is feasible at 666 MBq/kg without significant nonhematologic toxicity and with promising activity.	22700000
Central neuroblastoma	Stem Cell Exhaustion	Eligible patients were 1-30 y old with resistant neuroblastoma, (131)I-MIBG uptake, and cryopreserved hematopoietic stem cells.	22700000
Myelosuppression	Stem Cell Exhaustion	Autologous hematopoietic stem cells were infused 14 d after therapy to abrogate prolonged myelosuppression.	22700000
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	To investigate the association of the CD44+/CD24- cancer stem cell (CSC) ratio with clinicopathologic features and its prognostic value in breast cancer.	22702496
Graft-vs-Host Disease	Stem Cell Exhaustion	Toll-like receptor gene polymorphisms confer susceptibility to graft-versus-host disease in allogenic hematopoietic stem cell transplantation.	22703024
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GvHD) is a major complication in hematopoietic stem cell transplantation (HSCT).	22703024
Shock, Cardiogenic	Stem Cell Exhaustion	Bone marrow (BM)-derived mononuclear cell (MNC) preparations are increasingly used in experimental studies exploring the potential effect of progenitor cell-derived therapies in cardiocirculatory diseases.	22703161
Structure of vastus lateralis muscle	Stem Cell Exhaustion	Baseline and end-protocol evaluations included i) one incremental cardiopulmonary exercise test with near infrared spectroscopy analysis of peak deoxygenated hemoglobin+myoglobin concentration changes (D[deoxy(Hb+Mb)]) in vastus lateralis muscle, ii) 8 light-to-moderate-intensity constant-work-rate exercise tests for VO2 on-kinetics phase I duration, phase II t, and mean response time (MRT) assessment, and iii) circulating endothelial progenitor cell (EPC) measurement.	22703939
Cholestasis, Extrahepatic	Stem Cell Exhaustion	We report the clinical transplantation of a deceased donor iliac vein graft repopulated with recipient autologous stem cells in a patient with extrahepatic portal vein obstruction.	22704550
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation for intermediate cytogenetic risk AML in first CR.	22705800
Multiple Myeloma	Stem Cell Exhaustion	Serum free light chains and oligoclonal bands in patients with multiple myeloma and autologous stem cell transplantation.	22706252
Kidney Failure	Stem Cell Exhaustion	She underwent rituximab monotherapy and finally allogeneic hematopoietic stem cell transplantation in October 2010, but died of renal failure in February 2011.	22706530
Hematologic Neoplasms, Hepatitis B	Stem Cell Exhaustion	It has recently been reported that hepatitis B virus (HBV) reactivation in patients with hepatitis B surface antigen (HBsAg)-negative lymphoma during or after cytotoxic therapy occurs after the use of rituximab and stem cell transplantation for hematologic malignancies.	22706534
EYA1 wt Allele	Stem Cell Exhaustion	This is the first reported case of HBV reactivation in an HBsAg-negative myeloma patient treated with bortezomib (BOR) as salvage therapy and not stem cell transplantation.	22706534
Specialty Type - cancer	Stem Cell Exhaustion	CD44 is well known to be one of the cancer stem cell markers and is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion, and cell migration.	22706704
Amyloidosis	Stem Cell Exhaustion	Ten-year survival after autologous stem cell transplantation for immunoglobulin light chain amyloidosis.	22707405
Amyloidosis	Stem Cell Exhaustion	The current study was conducted to determine characteristics distinguishing the 10-year survivor group in patients with systemic immunoglobulin light chain (AL) amyloidosis who underwent autologous stem cell transplantation (SCT).	22707405
Bronchiolitis, Pleuropericarditis, Pneumonia, Interstitial	Stem Cell Exhaustion	Pleuropericarditis, obliterative bronchiolitis and lymphocytic interstitial pneumonitis after allogeneic haematopoietic stem cell transplantation.	22707568
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disorder of elderly people.	22709732
Acute GVH disease	Stem Cell Exhaustion	Anti-thymocyte globulin (thymoglobulin), tacrolimus, and sirolimus as acute graft-versus-host disease prophylaxis for unrelated hematopoietic stem cell transplantation.	22710143
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease (aGVHD) is a major cause of morbidity and mortality in patients undergoing unrelated hematopoietic stem cell transplantation.	22710143
Graft-vs-Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	These results suggest that the combination of Thymoglobulin, tacrolimus, and sirolimus in patients undergoing unrelated hematopoietic stem cell transplantation is well tolerated and associated with a low incidence and severity of aGVHD and chronic graft-versus-host disease.	22710143
Esophageal Neoplasms	Stem Cell Exhaustion	Quiescence and attenuated DNA damage response promote survival of esophageal cancer stem cells.	22711554
Cessation of life, Specialty Type - cancer	Stem Cell Exhaustion	Accumulating evidence indicates cancer stem cells (CSCs) possess the capability to resist DNA-damage induced cell death, whereas the mechanism is largely unknown.	22711554
Esophageal Neoplasms	Stem Cell Exhaustion	In this study, we isolated esophageal cancer stem cells (ECSCs) from esophageal cancer cell line EC9706 by side-population (SP) phenotype through flow cytometry and found that ECSCs preferentially stay quiescent as compared to the non-ECSCs and are more resistant to DNA damage agents.	22711554
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Underlying disease was acute myeloid leukemia in 45 patients (39%), and 21 (18%) were allogeneic stem cell transplant recipients.	22712457
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells are regarded as the origin of tumors that can proliferate, relapse, and metastasize.	22714588
Specialty Type - cancer	Stem Cell Exhaustion	Nanog, with its capacity to maintain the pluripotency and regulate proliferation and prevent differentiation, is one of the most important core markers of cancer stem cells.	22714588
Colorectal Carcinoma, Secondary malignant neoplasm of liver	Stem Cell Exhaustion	Stem cell gene Girdin: a potential early liver metastasis predictor of colorectal cancer.	22714912
Coronary Aneurysm	Stem Cell Exhaustion	Coronary artery aneurysm after implantation of an endothelial progenitor cell capturing stent.	22718389
Bacteremia, Intestinal Elimination	Stem Cell Exhaustion	Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation.	22718773
Bacteremia	Stem Cell Exhaustion	Bacteremia is a frequent complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT).	22718773
Mantle cell lymphoma	Stem Cell Exhaustion	CHOP and DHAP plus rituximab followed by autologous stem cell transplantation in mantle cell lymphoma: a phase 2 study from the Groupe d'Etude des Lymphomes de l'Adulte.	22718839
Rheumatoid Arthritis	Stem Cell Exhaustion	Intra-articular adipose-derived mesenchymal stem cells from rheumatoid arthritis patients maintain the function of chondrogenic differentiation.	22718867
Rheumatoid Arthritis, Degenerative polyarthritis	Stem Cell Exhaustion	To evaluate the chondrogenic potential, phenotype and percentage of IA adipose-derived mesenchymal stem cells (ADSCs) from RA patients in comparison with OA patients.	22718867
Prostate carcinoma	Stem Cell Exhaustion	In this study, we used quantitative real-time-PCR to define miRNA expression patterns in various stem/progenitor cell populations in prostate cancer, including CD44+, CD133+, integrin a2b1+, and side population cells.	22719071
Prostate carcinoma	Stem Cell Exhaustion	Multiple tumor-suppressive miRNAs were downregulated coordinately in several prostate cancer stem/progenitor cell populations, namely, miR-34a, let-7b, miR-106a, and miR-141, whereas miR-301 and miR-452 were commonly overexpressed.	22719071
Prostate carcinoma	Stem Cell Exhaustion	Distinct microRNA expression profiles in prostate cancer stem/progenitor cells and tumor-suppressive functions of let-7.	22719071
Specialty Type - cancer	Stem Cell Exhaustion	MiRNAs regulate cancer cells, but their potential effects on cancer stem/progenitor cells are still being explored.	22719071
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are a heterogenous group of clonal hematopoietic stem cell disorders.	22722455
Specialty Type - cancer	Stem Cell Exhaustion	We uncover a previously unknown link between the stem cell and oncogenic potential whereby b-catenin regulates Tert expression, and thereby telomere length, which could be critical in human regenerative therapy and cancer.	22723415
Specialty Type - cancer	Stem Cell Exhaustion	Wnt/b-catenin signaling regulates telomerase in stem cells and cancer cells.	22723415
Specialty Type - cancer	Stem Cell Exhaustion	Telomerase activity controls telomere length and plays a pivotal role in stem cells, aging, and cancer.	22723415
Diabetes Mellitus, Insulin-Dependent, Diabetic Ketoacidosis	Stem Cell Exhaustion	Diabetic ketoacidosis at diagnosis influences complete remission after treatment with hematopoietic stem cell transplantation in adolescents with type 1 diabetes.	22723579
Diabetic Ketoacidosis, diabetic	Stem Cell Exhaustion	To determine if autologous nonmyeloablative hematopoietic stem cell transplantation (AHSCT) was beneficial for type 1 diabetic adolescents with diabetic ketoacidosis (DKA) at diagnosis.	22723579
Chronic Kidney Disease, CTCAE	Stem Cell Exhaustion	Human embryonic mesenchymal stem cell-derived conditioned medium rescues kidney function in rats with established chronic kidney disease.	22723882
Dementia	Stem Cell Exhaustion	Genotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tau.	22723997
Erythroplasia, Lip and Oral Cavity Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Expression of cancer stem cell markers ALDH1 and Bmi1 in oral erythroplakia and the risk of oral cancer.	22725270
Specialty Type - cancer, S100A4 protein, human	Stem Cell Exhaustion	The objective of this study was to determine the expression of cancer stem cell markers ALDH1 and Bmi1 in OE and their correlation with malignant transformation of OE.	22725270
Graft-vs-Host Disease	Stem Cell Exhaustion	Acute graft versus host disease (aGvHD) is a major cause of early morbidity post-haematopoietic stem cell transplantation with minor histocompatibility antigens being a contributing factor.	22726315
Adverse Event Associated with Secondary Malignancy	Stem Cell Exhaustion	Secondary malignancy in the oral mucosa is recognized as one of the most serious complications in patients who received allogenic hematopoietic stem cell transplantation (HSCT).	22726540
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The relapse risk of AML patients undergoing autologous transplantation correlates with the stem cell mobilizing potential.	22727508
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) is widely used to consolidate first remission in AML.	22727508
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We determined the significance of circulating CD34+ cells at the day of blood stem cell collection in 78 AML patients.	22727508
Fever, Specialty Type - cancer, Fever of Unknown Origin, Communicable Diseases	Stem Cell Exhaustion	Prospective surveillance of fever of unknown origin (FUO), clinically documented infection and microbiologically documented infection (MDI) was conducted in the haemato-oncology and haematopoietic stem cell transplantation wards in a single cancer centre in Israel.	22727772
Multiple Myeloma	Stem Cell Exhaustion	Cytomegalovirus reactivation following autologous peripheral blood stem cell transplantation for multiple myeloma in the era of novel chemotherapeutics and tandem transplantation.	22728249
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	However, few studies have examined CMV reactivation after autologous peripheral blood stem cell transplantation (APBSCT) to treat multiple myeloma (MM), especially in the setting of the newer chemotherapeutic agents and/or 2 sequential APBSCTs (ie, tandem transplantation).	22728249
Multiple Myeloma	Stem Cell Exhaustion	For this patient, multiple myeloma with high KL-6 was refractory to chemotherapy, suggesting that new treatment strategies, including transplantation of hematopoietic stem cells, are required.	22728554
Multiple Myeloma	Stem Cell Exhaustion	Thalidomide plus dexamethasone as a maintenance therapy after autologous hematopoietic stem cell transplantation improves progression-free survival in multiple myeloma.	22730113
Multiple Myeloma	Stem Cell Exhaustion	Despite the good response of stem cell transplant (SCT) in the treatment of multiple myeloma (MM), most patients relapse or do not achieve complete remission, suggesting that additional treatment is needed.	22730113
Specialty Type - cancer, melphalan/prednisone protocol, Squamous cell carcinoma	Stem Cell Exhaustion	The side population (SP) with cancer stem cell-like properties and the main population (MP) were isolated from human A431 squamous carcinoma cells.	22732006
Carcinoma	Stem Cell Exhaustion	We postulate that carcinoma stem cells would be intrinsically primed to rapidly repair DNA damage by a high constitutive level of nuclear FGF2.	22732006
Aspergillosis	Stem Cell Exhaustion	Using the galactomannan antigen assay in the diagnosis of invasive aspergillosis after hematopoietic stem cell transplantation.	22732810
Infection, Aspergillosis	Stem Cell Exhaustion	Invasive aspergillosis (IA) is the most common life-threatening infections after hematopoietic stem cell transplant (HSCT).	22732810
Colorectal Carcinoma	Stem Cell Exhaustion	The transmembrane glycoprotein CD133 (cluster of differentiation 133; also known as Prominin or PROM1) has been described as a potential stem cell marker in colorectal cancer and is associated with higher tumorigenic potential and resistance to radiochemotherapy (RCT).	22736392
Ischemia	Stem Cell Exhaustion	Our data might provide a valuable snapshot at potential progenitor cells after acute ischaemia in vivo, and mapping of these easily accessible cells may influence future cell therapeutic strategies.	22736676
Gastrointestinal Stromal Tumors	Stem Cell Exhaustion	Stem cell factor-mediated wild-type KIT receptor activation is critical for gastrointestinal stromal tumor cell growth.	22736916
Gastrointestinal Stromal Tumors	Stem Cell Exhaustion	To clarify the biological role of stem cell factor (SCF)-mediated wild-type KIT receptor activation in gastrointestinal stromal tumor (GIST) growth.	22736916
Adult Glioblastoma, Fulfill	Stem Cell Exhaustion	The MET oncogene is a functional marker of a glioblastoma stem cell subtype.	22738909
Neoplasms	Stem Cell Exhaustion	However, the molecular alterations that drive stem cell proliferation in these tumors remain unknown.	22738909
Adult Glioblastoma, Specialty Type - cancer	Stem Cell Exhaustion	The existence of treatment-resistant cancer stem cells contributes to the aggressive phenotype of glioblastoma.	22738909
Adult Glioblastoma, Glioblastoma	Stem Cell Exhaustion	Together, our findings suggest that Met is a functional marker of glioblastoma stem cells and a candidate target for identification and therapy of a subset of glioblastomas.	22738909
Lymphoma	Stem Cell Exhaustion	[Clinical observation of 100 patients with malignant lymphoma treating with different preconditioning regimens followed by autologous hematopoietic stem cell transplantation].	22739163
Lymphoma	Stem Cell Exhaustion	This study was designed to compare the curative effect, prognosis and safety of different preconditioning regimens for patients who received autologous hematopoietic stem cell transplantation (AHSCT) for malignant lymphoma (ML).	22739163
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells (CSC) with several characteristics can lead to therapeutic resistance.	22739652
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	One of the factors responsible for recurrence is supposed to be cancer stem cells (CSCs) or tumor-initiating cells, which are a population of cancer cells with ability to perpetuate themselves through self-renewal and to generate differentiated cells, thought to be responsible for tumor recurrence.	22740326
Malignant tumor of colon	Stem Cell Exhaustion	This study globally approach the possible role of tissue-derived stem cells in the initiation of colon cancer and its metastatic process in the liver.	22740326
Adult Stem Cells	Stem Cell Exhaustion	Genomic instability and persistent DNA damage may cause loss of adult stem cell function.	22740444
Acquired (qualifier value)	Stem Cell Exhaustion	Humans accumulate microsatellite instability with acquired loss of MLH1 protein in hematopoietic stem and progenitor cells as a function of age.	22740444
Aspergillosis, Immunocompromised Host, Communicable Diseases	Stem Cell Exhaustion	Invasive aspergillosis (IA) is a life-threatening infection in severely immunocompromised patients, especially those receiving intensive chemotherapy or undergoing haematopoietic stem cell transplantation.	22740590
Childhood Breast Carcinoma	Stem Cell Exhaustion	The expression of SSEA-4 was related to clinico-pathological characteristics, to the expression of the adult stem cell antigens CD117, CD133 and breast cancer resistance protein 1 (BCRP1), and to prognosis.	22743677
Burn injury	Stem Cell Exhaustion	Reepithelialization from stem cells of hair follicles of dermal graft of the scalp in acute treatment of third-degree burns: first clinical and histologic study.	22743954
Hair follicle structure	Stem Cell Exhaustion	The purpose of this study was to double scalp harvesting in one procedure and to evaluate the capacity of the dermal layer to spontaneously reepithelialize from hair follicle stem cells.	22743954
Henoch-Schoenlein Purpura, Milk Allergy, Pyloric Stenosis, chlormadinone acetate, Celiac Disease, Gastrointestinal symptom	Stem Cell Exhaustion	Data of 5 studies with identical methodology to assess GI symptoms in children with celiac disease (CD), cow's milk allergy (CMA), pyloric stenosis (PS), Henoch-Schonlein purpura (HSP), and stem cell transplant (SC) and their healthy siblings were reviewed: a phone questionnaire on GI symptoms and Pediatric Gastrointestinal Symptoms Rome III version questionnaire (QPGS-RIII).	22744191
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Prospective study of erythropoietin use on quality of life and cost effectiveness in acute myeloid leukemia and allogeneic hematopoietic stem cell transplantation patients.	22744794
Anemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Despite frequent anemia and multiple transfusions in patients undergoing chemotherapy and allogeneic hematopoietic stem cell transplantation (allo-HSCT) for acute myeloid leukemia , recommendations for use of erythropoiesis-stimulating agents (ESAs) in these populations are still missing.	22744794
Left Ventricular Function	Stem Cell Exhaustion	The PERFECT trial has been designed as a prospective, randomized, double-blind, placebo controlled, multicenter trial, analyzing the effect of intramyocardial CD 133(+) bone marrow stem cell injection in combination with coronary artery bypass grafting on postoperative left ventricular function.	22747980
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease is a major complication after allogenic hematopoietic stem cell transplantation.	22748084
Malignant Peripheral Nerve Sheath Tumor, Myeloproliferative disease	Stem Cell Exhaustion	Myeloproliferative neoplasms (MPNs) result from genetically altered hematopoietic stem cells that retain the capacity for multilineage differentiation.	22749035
Communicable Diseases	Stem Cell Exhaustion	On univariable analysis, risk factors for reduced linezolid susceptibility included allogeneic hematopoietic stem cell transplant and/or solid organ transplant (odds ratio [OR]: 2.63; 95% confidence interval [CI]: 1.13-6.15; P = 0.025), receipt of immunosuppressive medications (OR: 2.39; 95% CI: 1.08-5.29; P = 0.032) including corticosteroids (OR: 2.40; 95% CI: 1.03-5.58; P = 0.042) and noncorticosteroid immunosuppressives (OR: 2.31; 95% CI: 1.00-5.30; P = 0.049), and receipt of linezolid within 1 year prior to infection (OR: 34.50, 95% CI: 4.60-259.02; P < 0.001).	22749382
Neutropenia	Stem Cell Exhaustion	Human granulocyte colony-stimulating-factor (G-CSF) is widely used for treatment of neutropenia and to mobilize stem/progenitor cells for bone marrow transplantation.	22751169
Coronary Arteriosclerosis	Stem Cell Exhaustion	To investigate the effects of age and disease on endogenous cardiac progenitor cells, we obtained right atrial and left ventricular epicardial biopsies from patients (n = 22) with chronic ischaemic heart disease and measured doubling time and surface marker expression in explant- and cardiosphere-derived cells (EDCs, CDCs).	22752803
NPM1 wt Allele	Stem Cell Exhaustion	Because RUNX1 mutations were more common in older patients and almost never coexisted with NPM1 mutations, RUNX1 mutation-associated expression signatures were derived in older, NPM1 wild-type patients and featured upregulation of genes normally expressed in primitive hematopoietic cells and B-cell progenitors, including DNTT, BAALC, BLNK, CD109, RBPMS, and FLT3, and downregulation of promoters of myelopoiesis, including CEBPA and miR-223.	22753902
Glioblastoma Multiforme Pathway, Neoplasms	Stem Cell Exhaustion	All of the tumor sphere cell populations showed a slower degree of cell proliferation than that of human glioma cells and fetal neural stem cells (NSCs).	22754374
Multiple Myeloma	Stem Cell Exhaustion	Multiple myeloma is incurable despite the advance of autologous stem cell transplant (ASCT) and novel agents (thalidomide, bortezomib, lenalidomide).	22757772
Multiple Myeloma	Stem Cell Exhaustion	Phase I trial of bortezomib during maintenance phase after high dose melphalan and autologous stem cell transplantation in patients with multiple myeloma.	22759762
Lymphoma, Non-Hodgkin, Multiple Myeloma	Stem Cell Exhaustion	Plerixafor as first- and second-line strategies for autologous stem cell mobilization in patients with non-Hodgkin's lymphoma or multiple myeloma.	22760691
Failure	Stem Cell Exhaustion	To describe the institutional experience of plerixafor plus filgrastim as the initial peripheral blood stem cell (PBSC) mobilization (first-line strategy) and as rescue therapy after failure with filgrastim plus cyclophosphamide (second-line strategy).	22760691
Hemangioma, Neoplasms	Stem Cell Exhaustion	Urethral hemangiomas are rare and benign tumors, probably originating from a unipotent angioblastic stem cell.	22760936
Hematopoietic stem cells, Cytopenia	Stem Cell Exhaustion	One third of patients have disease that is refractory to immunosuppression, with persistent, severe cytopenia and a profound deficit in hematopoietic stem cells and progenitor cells.	22762314
Ductal Carcinoma, Childhood Breast Carcinoma, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Although CD44+/CD24- cells are believed to act as breast cancer stem cells and to be linked to poor prognosis in some patients, the association between these cells and tumor recurrence or metastasis in all or some types of invasive ductal carcinoma is unclear.	22762532
Myeloproliferative disease, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder characterized by the expansion of a leukemic stem cell (LSC) clone, carrying a Philadelphia translocation, able to overcome the non-malignant hematopoietic stem cells.	22762548
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Outcome of allogeneic stem cell transplantation in myelodysplastic syndrome patients: prognostic implication of monosomal karyotype.	22762733
Gastrointestinal Stromal Tumors	Stem Cell Exhaustion	Given that the normal progenitor cell for GIST, the interstitial cell of Cajal, has characteristics similar to those of cells of neuroendocrine origin, we hypothesized that Notch pathway impacts the biology of GIST cells.	22764137
Cessation of life	Stem Cell Exhaustion	Treatment with mesenchymal stromal cells is a risk factor for pneumonia-related death after allogeneic hematopoietic stem cell transplantation.	22765507
Cessation of life	Stem Cell Exhaustion	Pneumonia-associated deaths were evaluated in 691 hematopoietic stem cell transplantation (HSCT) patients.	22765507
FLT3 Internal Tandem Duplication, Leukemia, Myelocytic, Acute, NPM1 wt Allele	Stem Cell Exhaustion	To investigate the role of reduced-intensity allogeneic (RIC-allo) stem cell transplant (SCT) as postremission therapy in adult intermediate-risk patients with acute myelogenous leukemia (AML) with FLT3-ITD or wild-type NPM1 and CEBPA without FLT3-ITD, we conducted a single-center retrospective study between January 2001 and December 2010.	22766221
Parathyroid Gland Adenocarcinoma	Stem Cell Exhaustion	A subset of over-expressed microRNAs (miRNAs) identified in parathyroid carcinomas (Ca) compared to normal glands belongs to C19MC, a cluster on chromosome 19q13.4 involved in stem cell biology and tumourigenesis.	22767050
Lymphoma, Follicular, Neoplasms	Stem Cell Exhaustion	A 4-weekly course of rituximab is safe and improves tumor control for patients with minimal residual disease persisting 3 months after autologous hematopoietic stem-cell transplantation: results of a prospective multicenter phase II study in patients with follicular lymphoma.	22767588
Lymphoma, Follicular	Stem Cell Exhaustion	This study explored the efficacy and safety of rituximab as treatment of clinical or molecular residual disease after autologous stem-cell transplantation (ASCT) in follicular lymphoma (FL).	22767588
Aggressive course, Specialty Type - cancer	Stem Cell Exhaustion	Podocalyxin-like 1 (PODXL) is a cell-adhesion glycoprotein and stem cell marker that has been associated with an aggressive tumour phenotype and adverse outcome in several cancer types.	22769594
Diabetes	Stem Cell Exhaustion	(2012) demonstrate that the diabetes medication metformin enhances spatial learning in mice by activating the atypical PKC/CBP pathway in adult neural stem cells.	22770236
Inferior vena cava structure	Stem Cell Exhaustion	Inferior vena cava (IVC) and renal vein (RV) levels of CD34+/KDR+ progenitor cells, cell adhesion molecules, inflammatory biomarkers, progenitor cell homing signals, and pro-angiogenic factors were measured in EH and ARAS, and their gradient and net release compared with systemic levels in matched normotensive controls (n= 24).	22771675
Influenza due to Influenza A virus subtype H1N1	Stem Cell Exhaustion	Outbreak of pandemic 2009 influenza A/H1N1 infection in the hematology ward: fatal clinical outcome of hematopoietic stem cell transplant recipients and emergence of the H275Y neuraminidase mutation.	22773299
Influenza due to Influenza A virus subtype H1N1, Influenza, Hematologic Neoplasms	Stem Cell Exhaustion	A total of seven hospitalized patients with hematologic tumors, including five recipients of hematopoietic stem cell transplantation (HSCT), successively developed rapid influenza detection test (RIDT)-positive influenza A; four patients had laboratory-confirmed 2009 H1N1 infection.	22773299
Acute Cerebrovascular Accidents	Stem Cell Exhaustion	CD34/CXCR4 stem cell dynamics in acute stroke patients.	22773459
Ischemic stroke	Stem Cell Exhaustion	Non-hematopoietic stem cells may be a source of paracrine and structural regeneration for brain damaged by acute ischemic stroke.	22773459
Acute Cerebrovascular Accidents	Stem Cell Exhaustion	In this study, we investigated correlations of CD34-, CD34/CXCR4-, and CXCR4-positive peripheral blood CD45-negative stem cells with the neurological and functional status of 34 acute stroke patients.	22773459
Nervous System Physiological Phenomena, Acute Cerebrovascular Accidents	Stem Cell Exhaustion	We report that the number and dynamic changes in levels of non-hematopoietic CD34-, CD34/CXCR4-, and CXCR4-positive stem cells tend to correlate with acute stroke patients' neurologic and functional status.	22773459
Heart failure	Stem Cell Exhaustion	Testosterone deficiency in male heart failure patients and its effect on endothelial progenitor cells.	22776027
Fibrosis Assessment	Stem Cell Exhaustion	Adipose-derived stem cells can abrogate chemical-induced liver fibrosis and facilitate recovery of liver function.	22776464
Coronary Arteriosclerosis	Stem Cell Exhaustion	Correlation between the functional impairment of bone marrow-derived circulating progenitor cells and the extend of coronary artery disease.	22776510
Coronary heart disease	Stem Cell Exhaustion	Bone marrow-derived circulating progenitor cells (BM-CPCs) in patients with coronary heart disease are impaired with respect to number and functional activity.	22776510
Stem Cell Factor, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	[Expression of phosphorylated STAT5 in bone marrow hematopoietic stem cells of patients with paroxysmal nocturnal hemoglobinuria before and after in vitro G-CSF or SCF stimulation].	22781567
Multiple Myeloma	Stem Cell Exhaustion	[The efficacy and safety of bortezomib-based induction regimen before autologous hematopoietic stem cell transplantation in patients with multiple myeloma].	22781947
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	To investigate the efficacy and safety of bortezomib-based induction regimen followed by autologous hematopoietic stem cell transplantation (ASCT) in patients with multiple myeloma (MM).	22781947
Peripheral Blood Stem Cells	Stem Cell Exhaustion	Furthermore, engraftment of neutrophil and platelet in patients receiving peripheral blood stem cell transplantation were faster than those receiving bone marrow transplantation.	22781947
Specialty Type - cancer, S100A4 protein, human, Leukoplakia	Stem Cell Exhaustion	Expression patterns of cancer stem cell markers ALDH1 and CD133 correlate with a high risk of malignant transformation of oral leukoplakia.	22782852
Lip and Oral Cavity Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	The objective of this study was to examine the expression patterns of cancer stem cell markers ALDH1 and CD133 in samples from patients with OL, and determine their prognostic values for subsequent development of oral cancer.	22782852
Respiratory Syncytial Virus Infections	Stem Cell Exhaustion	An outbreak of respiratory syncytial virus infection in hematopoietic stem cell transplantation outpatients: good outcome without specific antiviral treatment.	22783905
Virus Diseases	Stem Cell Exhaustion	Respiratory syncytial virus (RSV) is a common cause of seasonal respiratory viral infection in hematopoietic stem cell transplantations (HSCT) patients.	22783905
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GVHD) is a major barrier to successful allogeneic hematopoietic stem-cell transplantation (HSCT).	22784116
Ischemic stroke	Stem Cell Exhaustion	Fantasies about stem cell therapy in chronic ischemic stroke patients.	22784218
nervous system disorder	Stem Cell Exhaustion	Stem cell therapy (SCT) has been proposed for the treatment of neurological disorders.	22784218
Specialty Type - cancer, Squamous cell carcinoma	Stem Cell Exhaustion	ABCB5 expression and cancer stem cell hypothesis in oral squamous cell carcinoma.	22784549
SERPINB3 wt Allele, Specialty Type - cancer	Stem Cell Exhaustion	The effectiveness of adjuvant cytostatic chemotherapy for OSCC is frequently restricted due to an inducible cellular mechanism called multidrug resistance (MDR) and a putative cancer stem cell (CSC) compartment in human carcinogenesis expressing multidrug efflux pumps.	22784549
Specialty Type - cancer	Stem Cell Exhaustion	One of the principal mechanisms for protecting putative cancer stem cells is through the expression of multifunctional efflux transporters from the ABC gene family, like ABCB5.	22784549
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	This provides one mechanism in which putative cancer stem cells could survive and may lead to tumour relapse.	22784549
Hypoxia, BCR gene	Stem Cell Exhaustion	Co-culture of pre-B ALL or REH cells with BM-derived mesenchymal stem cells (MSC) under hypoxia resulted in further induction of HIF-1a protein and acquisition of the glycolytic phenotype, in part via stroma-induced AKT/mTOR signaling.	22785211
Vascular System Injuries	Stem Cell Exhaustion	Circulating endothelial cells (CECs) were measured as a marker of vascular injury, with vascular repair assessed by counting colony-forming units (CFUs), also known as endothelial progenitor cells.	22785446
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	Treatment of recurrent acute lymphoblastic leukaemia (ALL) often involves allogeneic stem-cell transplantation (alloSCT) and disease recurrence in the central nervous system may require craniospinal irradiation.	22787181
Glioblastoma Multiforme Pathway, Adult Glioblastoma, Astrocytoma, Glioblastoma	Stem Cell Exhaustion	Using pyrosequencing, we detected RANK/TNFRSF11A promoter methylation in 8 (57.1%) of 14 diffuse astrocytomas, 17 (77.3%) of 22 anaplastic astrocytomas, 101 (84.2%) of 120 glioblastomas, 6 (100%) of 6 glioma cell lines, and 7 (100%) of 7 glioma stem cell-enriched glioblastoma primary cultures but not in four normal white matter tissue samples.	22787434
Pterygium	Stem Cell Exhaustion	The use of fibrin glue, which has been reported extensively in pterygium and other conjunctival surgeries, has not been fully described in limbal stem cell transplantation.	22788584
Acute GVH disease	Stem Cell Exhaustion	A 26-year-old man received FK506 to prevent acute graft-versus-host disease after hematopoietic stem cell transplantation.	22790031
Graft-vs-Host Disease, Secondary Graft Failure After Hematopoietic Cell Transplantation, Primary Graft Failure After Hematopoietic Cell Transplantation, Communicable Diseases	Stem Cell Exhaustion	In patients with secondary failure of platelet recovery (N=7) as well as primary failure after hematopoietic stem cell transplantation, TPO levels were very high, reflecting impaired platelet production due to GVHD, drug treatments, and infection.	22790640
Hiccough, Diarrhea, Abdomen distended	Stem Cell Exhaustion	His presentation with hiccups, abdominal and neck distension, along with diarrhoea was also unusual, and this case highlights the need for a high index of suspicion when treating post stem cell transplant patients.	22791490
Aplastic Anemia	Stem Cell Exhaustion	Aplastic anemia is a rare disease caused by destruction of pluripotent stem cells in bone marrow.	22796618
Medial collateral ligament	Stem Cell Exhaustion	Patients with MCL who underwent autologous stem-cell transplantation (ASCT) in our institution were eligible for the present study (n=73).	22797728
Femoral Neuropathy	Stem Cell Exhaustion	The patient had a total hip replacement at a specialist orthopaedic hospital and is due to undergo radiotherapy to the femoral lesion and autologous stem cell transplantation.	22798312
Adult Glioblastoma	Stem Cell Exhaustion	MGMT hypermethylation and MDR system in glioblastoma cancer stem cells.	22798502
Glioma, Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells (CSCs) in gliomas are associated with resistance to radio- and chemotherapy, based on O(6)-methylguanine-DNA methyltransferase (MGMT) hypermethylation and the Multidrug resistance (MDR) system activation.	22798502
Arrhythmogenic Right Ventricular Dysplasia	Stem Cell Exhaustion	Generation of patient-specific induced pluripotent stem cell-derived cardiomyocytes as a cellular model of arrhythmogenic right ventricular cardiomyopathy.	22798562
Multiple Myeloma	Stem Cell Exhaustion	Significance of oligoclonal bands after stem cell transplantation in multiple myeloma cases.	22799352
nervous system disorder	Stem Cell Exhaustion	Analysis of post-mortem frontal cortex tissue from 7 GBA mutation carriers with LBD, 5 GBA mutation carriers with no signs of neurological disease and human neural stem cells exposed to a GCase inhibitor was used to determine how GBA mutation contributes to LBD.	22803570
Pneumonia	Stem Cell Exhaustion	Organizing pneumonia in recipients of hematopoietic stem cell transplantation: CT features in 16 patients.	22805673
Pneumonia	Stem Cell Exhaustion	To evaluate computed tomographic (CT) scans of patients with organizing pneumonia (OP) complicating hematopoietic stem cell transplantation (HSCT).	22805673
Kidney Diseases	Stem Cell Exhaustion	De novo postallogeneic hematopoietic stem cell transplant membranous nephropathy.	22809119
Kidney Diseases, Chronic graft-versus-host disease	Stem Cell Exhaustion	We report membranous nephropathy in a 61-year-old man after allogeneic hematopoietic stem cell transplant without chronic graft-versus-host disease.	22809119
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A diagnosis of acute myeloid leukemia was made, and the patient received hematopoietic stem cell transplants, twice, from different donors.	22809119
Chronic graft-versus-host disease, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	His clinical course was stable without acute or chronic graft-versus-host disease or relapse of acute myeloid leukemia with tacrolimus after the second hematopoietic stem cell transplant.	22809119
Kidney Diseases, Chronic graft-versus-host disease	Stem Cell Exhaustion	These results suggest that this membranous nephropathy may have been de novo membranous nephropathy after hematopoietic stem cell transplant because it developed after hematopoietic stem cell transplants without chronic graft-versus-host disease.	22809119
Ischemia	Stem Cell Exhaustion	Ischemia may induce brain self-repair in neonatal rats, resulting in activation and proliferation of NG2 glial progenitor cells in the SVZ migration and differentiation into OL precursor cells in periventricular white matter.	22809613
Mycoses	Stem Cell Exhaustion	Comparison of posaconazole versus weekly amphotericin B lipid complex for the prevention of invasive fungal infections in hematopoietic stem-cell transplantation.	22814329
Mycoses	Stem Cell Exhaustion	Antifungal prophylaxis is shown to decrease the risk of invasive fungal infection (IFI) after hematopoietic stem-cell transplantation (HSCT).	22814329
Chronic Kidney Disease, CTCAE	Stem Cell Exhaustion	Value and level of circulating endothelial progenitor cells, angiogenesis factors and mononuclear cell apoptosis in patients with chronic kidney disease.	22814956
Kidney Failure, Chronic, Chronic Kidney Diseases, Chronic Kidney Disease, CTCAE	Stem Cell Exhaustion	Chronic renal failure on dialysis can reduce the number of circulating endothelial progenitor cells (EPCs), but this biomarker has not been fully investigated in patients with chronic kidney disease (CKD).	22814956
Hepatic Encephalopathy, Multiple Myeloma	Stem Cell Exhaustion	Posterior reversible encephalopathy syndrome postautologous peripheral stem cell transplantation for multiple myeloma.	22814980
Multiple Myeloma	Stem Cell Exhaustion	This is a case of a 56-year-old lady with recent autologous peripheral stem cell transplantation for multiple myeloma.	22814980
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Patients with multiple myeloma (MM) undergoing high dose therapy and autologous stem cell transplantation (SCT) remain at risk for disease progression.	22816680
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	To better understand clonal evolution in AML, we sequenced the genomes of M3-AML samples with a known initiating event (PML-RARA) versus the genomes of normal karyotype M1-AML samples and the exomes of hematopoietic stem/progenitor cells (HSPCs) from healthy people.	22817890
Lupus Erythematosus	Stem Cell Exhaustion	Upregulation of p16INK4A promotes cellular senescence of bone marrow-derived mesenchymal stem cells from systemic lupus erythematosus patients.	22820504
Lupus Erythematosus, Systemic, Encephalitis, St. Louis	Stem Cell Exhaustion	Previous studies have indicated that bone marrow-derived mesenchymal stem cells (MSCs) from patients with systemic lupus erythematosus (SLE) exhibited impaired proliferation, differentiation, and immune modulation capacities.	22820504
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Allogeneic stem cell transplantation for older advanced MDS patients: improved survival with young unrelated donor in comparison with HLA-identical siblings.	22821073
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We investigated whether a young human leukocyte antigen (HLA)-matched unrelated donor (MUD) should be preferred as donor to an HLA-identical sibling (MRD) for older patients with myelodysplastic syndrome (MDS) (>= 50 years) who underwent allogeneic stem cell transplantation (AHSCT).	22821073
Malignant neoplasm of ovary	Stem Cell Exhaustion	Functional study of risk loci of stem cell-associated gene lin-28B and associations with disease survival outcomes in epithelial ovarian cancer.	22822098
Cancer Pain, Malignant neoplasm of ovary	Stem Cell Exhaustion	Several single-nucleotide polymorphisms (SNPs) of the stem cell-associated gene lin-28B have been identified in association with ovarian cancer and ovarian cancer-related risk factors.	22822098
Specialty Type - cancer	Stem Cell Exhaustion	These results suggest that rs314276 alters RNA secondary structure and thereby influences gene expression, and that lin-28B is a cancer stem cell-associated marker, which may be a pharmaceutical target in the management of EOC.	22822098
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We report the case of a 61-year-old man who had hematopoietic stem cell transplant for myelodysplastic syndrome.	22823898
Adult Glioblastoma	Stem Cell Exhaustion	In this study, we characterized p53 isoform expression patterns in glioblastoma, gliosis, non-tumor brain and neural progenitor cells by SDS-PAGE, immunoblot, mass spectrometry and reverse transcription-PCR.	22824800
Adult Glioblastoma, Neoplasms	Stem Cell Exhaustion	We found that the most consistently expressed isoform in glioblastoma, D40p53, was uniquely expressed in regenerative processes, such as those involving neural progenitor cells and gliosis compared with tumor samples.	22824800
Pancreatic Ductal Adenocarcinoma, Pancreatic intraepithelial neoplasia, Specialty Type - cancer	Stem Cell Exhaustion	Expression of cancer stem cell markers in pancreatic intraepithelial neoplasias and pancreatic ductal adenocarcinomas.	22824809
Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	Cancer stem cells (CSCs) play pivotal roles in cancer growth, invasion, metastasis and recurrence.	22824809
Liver Cirrhosis	Stem Cell Exhaustion	Increased number and function of endothelial progenitor cells stimulate angiogenesis by resident liver sinusoidal endothelial cells (SECs) in cirrhosis through paracrine factors.	22824816
Liver Cirrhosis	Stem Cell Exhaustion	The present study focused on numbers and angiogenic functions of circulating endothelial progenitor cells (EPCs) in patients with cirrhosis.	22824816
Aplastic Anemia	Stem Cell Exhaustion	A novel autologous stem cell procedure for the treatment of aplastic anaemia using reprogrammed mature adult cells: a pilot study.	22825605
Aplastic Anemia	Stem Cell Exhaustion	This autologous approach of stem cell creation may broaden the curative potentials of stem cell therapy to a wider population of patients with aplastic anaemia, including many patients suffering from other haematological and non-haematological disorders.	22825605
Aplastic Anemia	Stem Cell Exhaustion	Herein, the safety and efficacy of infusing autologous retrodifferentiated haematopoietic stem cells (RHSC) into four patients with aplastic anaemia without the use of any pre- or post-conditioning regimen including immunosuppression is described.	22825605
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The KIT gene is a receptor tyrosine kinase class III expressed by early hematopoietic progenitor cells and plays a significant role in hematopoietic stem cell proliferation, differentiation and survival which is considered to be a remarkable feature in the course of growth of acute myeloid leukaemia (AML).	22825855
Sarcoma of vulva, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We report a case of vulvar myeloid sarcoma presenting as isolated relapse of acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplant (HSCT).	22828376
Therapy-Related Toxicity	Stem Cell Exhaustion	In allogeneic hematopoietic stem cell transplantation (allo-HSCT) therapy-related toxicity and alloreactivity increase inflammatory cytokines that might favor an MDSC accumulation.	22828446
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Complex karyotype (CK) on metaphase cytogenetics discriminates poor outcome in chronic lymphocytic leukaemia (CLL) patients undergoing salvage treatment; we hypothesized that it might provide prognostic information for patients undergoing allogeneic stem cell transplant.	22831395
Medial collateral ligament	Stem Cell Exhaustion	Survival improvement has recently been achieved for patient with MCL by the successful introduction of monoclonal antibodies and dose-intensified approaches for treatment, including autologous stem cell transplantation strategies.	22832802
Heart Diseases	Stem Cell Exhaustion	The effects of age, disease state, and granulocyte colony-stimulating factor on progenitor cell count and function in patients undergoing cell therapy for cardiac disease.	22834565
Heart failure, Acute myocardial infarction, Dilated Cardiomyopathy Pathway, Myocardial Ischemia, Doctor of Chiropractic	Stem Cell Exhaustion	In this exploratory analysis, we assessed the impact of age, different disease states, and granulocyte colony-stimulating factor (G-CSF) therapy on progenitor cell concentration and function in patients recruited to our clinical trials of BMSC therapy for ischaemic heart failure (IHD), dilated cardiomyopathy (DCM), and acute myocardial infarction (AMI).	22834565
Chronic graft-versus-host disease	Stem Cell Exhaustion	Allogeneic peripheral blood stem cell transplantation significantly increases risk of chronic graft-versus-host disease of lung compared with bone marrow transplantation.	22835425
Bare Lymphocyte Syndrome, Peripheral Blood Stem Cells, Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	Passenger lymphocyte syndrome with hemophagocytic syndrome after peripheral blood stem-cell transplantation from an HLA-matched full biological sibling: case report.	22836124
Bare Lymphocyte Syndrome, Hemolysis (biological function), Papillon-Lefevre Disease	Stem Cell Exhaustion	Massive hemolysis due to passenger lymphocyte syndrome (PLS) is rare after peripheral blood stem-cell (PBSC) transplantation with a minor ABO mismatch.	22836124
Acute lymphocytic leukemia, Lymphoma, Myeloid Leukemia, Chronic, Myeloid, Leukemic Blast Count, Leukemia, Myelocytic, Acute, BCR gene	Stem Cell Exhaustion	Its expression was observed in hematopoietic CD34+ stem cells, erythropoietic, myeloid and lymphoblastic lineages cell lines and in human leukemic blast cells in lymphomas, acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and chronic myeloid leukemia (CML).	22836631
Liver Cirrhosis	Stem Cell Exhaustion	Stem cell niche activation (as indicated as a ductular reaction) was highest in cases of cirrhosis (p = 0.001) and correlated with CK19 expression (r = 0.42, p = 0.012), the grade(r = 0.56, p = 0.024) and stage (0.66, p = 0.006).	22839096
Fibrosis Assessment, Hollings Cancer Center, Carcinogenesis	Stem Cell Exhaustion	Fibrosis promotes carcinogenesis by fibroblast-secreted gremlin that blocks BMP function and promotes stem cell activation and proliferation as well as possibly HCC development.	22839096
LMNA wt Allele	Stem Cell Exhaustion	Recent studies based on induced pluripotent stem cells derived from HGPS patient cells have revealed a lack of expression in neural derivatives of lamin A, a major isoform of LMNA that is initially produced as a precursor called prelamin A.	22840390
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (SCT) is routinely offered to suitable candidates with high-risk or advanced acute lymphoblastic leukemia (ALL).	22842330
Amyloidosis	Stem Cell Exhaustion	Amyloid deposits in the bone marrow of patients with immunoglobulin light chain amyloidosis do not impact stem cell mobilization or engraftment.	22842332
Multiple Myeloma	Stem Cell Exhaustion	Comparative diagnostic performance of 18F-FDG PET/CT versus whole-body MRI for determination of remission status in multiple myeloma after stem cell transplantation.	22843058
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	To compare the diagnostic performance of whole-body magnetic resonance imaging (WBMRI) versus (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) for determination of remission status in patients with multiple myeloma (MM) after stem cell transplantation (SCT).	22843058
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	Detection of mesenchymal and cancer stem cells, which are tumor-initiating cells, is more relevant than simple counting of CTCs to assess their presence in the blood of patients with breast cancer.	22843916
Graft-vs-Host Disease, Leukemia, Myelocytic, Acute, Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Regression of a renal cell carcinoma following allogeneic peripheral blood stem cell transplant for acute myeloid leukaemia: evidence of a graft-versus-tumour effect without significant graft-versus-host disease.	22845006
Glioma, Aortic Aneurysm, Specialty Type - cancer	Stem Cell Exhaustion	This study evaluated the safety and immune responses to an autologous dendritic cell vaccine pulsed with class I peptides from tumor-associated antigens (TAA) expressed on gliomas and overexpressed in their cancer stem cell population (ICT-107).	22847020
Adult Glioblastoma, Neoplasms	Stem Cell Exhaustion	The goal of targeting tumor antigens highly expressed on glioblastoma cancer stem cells is supported by the observation of decreased or absent CD133 expression in the recurrent areas of gadolinium-enhanced tumors.	22847020
Thrombocytosis, Hematological Disease, Primary Myelofibrosis, Myeloid Leukemia, Chronic, Polycythemia Vera, Chronic myeloproliferative disorder, PRSS27 gene	Stem Cell Exhaustion	Chronic myeloproliferative neoplasms (MPN) are clonal disorders of hematopoietic stem cells, which fall into distinct categories based on a number of characteristics including the presence of the BCR-ABL1 gene fusion (chronic myelogenous leukemia) or the JAK2(V617F) mutation (polycythemia vera, primary myelofibrosis, and essential thrombocythemia).	22847163
Disease, Neurodegenerative Disorders	Stem Cell Exhaustion	Induced pluripotent stem cell (iPSC) technology can be used to model human disorders, create cell-based models of human diseases, including neurodegenerative diseases, and in establishing therapeutic strategies.	22848530
Neurodegenerative Disorders	Stem Cell Exhaustion	Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research.	22848530
Teratoma	Stem Cell Exhaustion	It is postulated that the teratoid elements might derive from multipotential less-differentiated stem cells.	22849740
Graft-vs-Host Disease	Stem Cell Exhaustion	Therapeutic drug monitoring of posaconazole in allogeneic hematopoietic stem cell transplantation patients who develop gastrointestinal graft-versus-host disease.	22850515
Graft-vs-Host Disease, Immunocompromised Host, Aspergillosis	Stem Cell Exhaustion	Posaconazole (PCZ) is the latest triazole antifungal agent that has been approved for prophylaxis of invasive aspergillosis in high-risk immunocompromised patients, such as allogeneic hematopoietic stem cell transplantation patients, who develop graft-versus-host disease (GVHD).	22850515
Graft-vs-Host Disease, Diarrhea, Aspergillosis	Stem Cell Exhaustion	To determine the variability factors in plasma drug concentrations, the PCZ C(min) and clinical parameters (localization of GVHD, presence of diarrhea, and diagnosis of invasive aspergillosis) were collected retrospectively in 29 consecutive allogeneic hematopoietic stem cell transplantation patients who developed GVHD and were receiving prophylactic PCZ (200 mg, 3 times/day, for >=7 days).	22850515
Immunocompromised Host, Systemic EBV positive T-cell lymphoproliferative disease of childhood, Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	Hosts that are immunocompromised after hematopoietic stem cell transplantations sometimes suffer from systemic EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH) and EBV-positive lymphoma.	22850617
Pulmonary Emphysema	Stem Cell Exhaustion	Impaired colony-forming capacity of circulating endothelial progenitor cells in patients with emphysema.	22850689
Heart failure	Stem Cell Exhaustion	The impressive recovery in ventricular hemodynamics and anatomy mediated by clonal hCSCs carrying the "mother" DNA underscores the clinical relevance of this stem cell class for the management of heart failure in humans.	22851539
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Up-front autologous stem-cell transplantation in peripheral T-cell lymphoma: NLG-T-01.	22851556
Peripheral T-Cell Lymphoma, Lymphoma	Stem Cell Exhaustion	To evaluate the efficacy of a dose-dense approach consolidated by up-front high-dose chemotherapy (HDT) and autologous stem-cell transplantation (ASCT) in PTCL, the Nordic Lymphoma Group (NLG) conducted a large prospective phase II study in untreated systemic PTCL.	22851556
Ki-1+ Anaplastic Large Cell Lymphoma	Stem Cell Exhaustion	Efficacy of peripheral blood stem cell transplantation versus conventional chemotherapy on anaplastic large-cell lymphoma:a retrospective study of 64 patients from a single center.	22854061
Ki-1+ Anaplastic Large Cell Lymphoma	Stem Cell Exhaustion	Many groups believed aggressive treatment strategies such as autologous stem cell transplantation brought survival benefit for ALCL patients.	22854061
Ki-1+ Anaplastic Large Cell Lymphoma	Stem Cell Exhaustion	Here, we report a study comparing the efficacy of peripheral blood stem cell transplantation (PBSCT) and conventional chemotherapy on ALCL.	22854061
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	Brentuximab vedotin induces durable objective responses in patients with relapsed or refractory Hodgkin lymphoma (HL) after autologous stem cell transplantation (ASCT).	22855426
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Our goal was to investigate the outcomes associated with distinct high-risk chromosomal abnormalities in acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (HSCT).	22855604
Colorectal Carcinoma, Specialty Type - cancer, Cytogenetic Complete Response	Stem Cell Exhaustion	CD133 is considered a useful marker to identify the so-called cancer stem cells in colorectal cancers (CRCs) and its expression has been shown to have prognostic significance in CRC patients.	22856425
Delirium	Stem Cell Exhaustion	Risk factors for delirium in patients undergoing hematopoietic stem cell transplantation.	22860240
Delirium	Stem Cell Exhaustion	Delirium is common after hematopoietic stem cell transplantation (HSCT) and is associated with increased morbidity and mortality.	22860240
Venous Thrombosis, Paroxysmal nocturnal hemoglobinuria, Acquired disorder, Anemia, Hemolytic	Stem Cell Exhaustion	PNH is an acquired disorder of stem cells, and the common manifestations are complement mediated hemolytic anemia and deep venous thrombosis.	22860310
Lung Diseases, Fungal, Hematologic Neoplasms	Stem Cell Exhaustion	Risk factors for invasive pulmonary fungal infection in patients with hematological malignancies not receiving hematopoietic stem cell transplant.	22862167
Lung Diseases, Fungal, Hematologic Neoplasms	Stem Cell Exhaustion	We investigated the incidence, pathogens and risk factors of invasive pulmonary fungal infection (IPFI) in patients with hematological malignancies who did not receive hematopoietic stem cell transplantation (HSCT).	22862167
Enterocolitis, Neutropenic	Stem Cell Exhaustion	Neutropenic enterocolitis after high-dose chemotherapy and autologous stem cell transplantation: incidence, risk factors, and outcome.	22862907
Enterocolitis, Neutropenic	Stem Cell Exhaustion	Neutropenic enterocolitis (NE) is a life-threatening complication occurring after intensive chemotherapy; however, no data are available on NE development after hematopoietic stem cell transplantation (SCT).	22862907
Childhood Breast Carcinoma	Stem Cell Exhaustion	Long-term survival in patients with metastatic breast cancer receiving intensified chemotherapy and stem cell rescue: data from the Italian registry.	22863724
diabetic	Stem Cell Exhaustion	Prompt increases in retinol-binding protein 4 and endothelial progenitor cells during acute exercise load in diabetic subjects.	22863748
diabetic	Stem Cell Exhaustion	The present study was undertaken to determine whether acute exercise load alters serum retinol-binding protein 4 (RBP4) and numbers of endothelial progenitor cells (EPC) in diabetic subjects.	22863748
Have Been Vomiting, Nausea	Stem Cell Exhaustion	Prevention of nausea and vomiting associated with stem cell transplant: results of a prospective, randomized trial of aprepitant used with highly emetogenic preparative regimens.	22863840
Have Been Vomiting, Nausea	Stem Cell Exhaustion	Uncontrolled delayed nausea and vomiting remains a problem after high-dose preparative regimens used for autologous and allogeneic hematopoietic stem cell transplants.	22863840
Carcinoma of ampulla of Vater	Stem Cell Exhaustion	We measured the serum levels of the hematopoietic cytokines stem cell factor (SCF), interleukin 3 (IL-3), macrophage-colony stimulating factor (M-CSF) and granulocyte-macrophage-colony stimulating factor (GM-CSF) in 40 pancreatic and ampullary cancer patients and 40 healthy volunteers, using ELISA.	22865301
BCR gene	Stem Cell Exhaustion	HLAA, -B, and -DRB1 allele distributions in 156 ALL patients (aged 3-54 years) were analyzed and compared with unrelated healthy hematopoietic stem cell donors from the same ethnic and geographic background.	22868506
Ischemia	Stem Cell Exhaustion	Possible predictors of poor angiogenesis after hematopoietic stem cell autograft for lower limb ischemia.	22869247
Ischemia	Stem Cell Exhaustion	Identify candidate predictors of poor angiogenesis, as indicated by need for amputation, after autologous hematopoietic stem cell transplantation for chronic lower limb ischemia.	22869247
Ischemia	Stem Cell Exhaustion	The study universe was composed of 47 patients (19 women, 28 men) with critical lower limb ischemia in Fontaine stages IIb, III and IV, who received autologous stem cell transplantation at the Dr Gustavo Aldereguia Lima University General Hospital in Cienfuegos, Cuba, from January 2007 through December 2010.	22869247
Peripheral Vascular Diseases	Stem Cell Exhaustion	The therapeutic potential of adult stem cells in coronary and peripheral arterial diseases has been proposed in recent years.	22869247
Bronchiolitis Obliterans	Stem Cell Exhaustion	Lung transplantation for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation.	22869493
Bronchiolitis Obliterans, bottle - unit dose	Stem Cell Exhaustion	Bronchiolitis obliterans (BO) is a late onset complication of allogeneic hematopoietic stem cell transplantation (HSCT), and treatment outcome is dismal if it does not respond to immunosuppressive therapy.	22869493
Graft-vs-Host Disease	Stem Cell Exhaustion	HLA-mismatched unrelated donor (MMUD) hematopoietic stem-cell transplantation (HSCT) is associated with increased graft-versus-host disease (GVHD) and impaired survival.	22869883
Peripheral Blood Stem Cells, Hematologic Neoplasms	Stem Cell Exhaustion	We conducted a prospective phase I/II trial of a GVHD prophylaxis regimen of short-course bortezomib, administered once per day on days +1, +4, and +7 after peripheral blood stem-cell infusion plus standard tacrolimus and methotrexate in patients with hematologic malignancies undergoing MMUD RIC HSCT.	22869883
Adenocarcinoma of large intestine	Stem Cell Exhaustion	This study shows that CD133 is able to mark colorectal adenocarcinoma but it is still unclear at this juncture whether CD133 is indeed a marker for colorectal adenocarcinoma "stem cells".	22870594
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Further investigations on how high expression of CXCR4 and EMT occur in this identified cancer stem cell subset are warranted to provide insights into our understanding of tumor biology.	22871210
Specialty Type - cancer	Stem Cell Exhaustion	Growing evidence suggests that a subset of cells exists among cancer stem cells.	22871210
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal hematopoietic stem cell diseases.	22873198
Toxic effect	Stem Cell Exhaustion	Ketamine induces toxicity in human neurons differentiated from embryonic stem cells via mitochondrial apoptosis pathway.	22873495
Multiple Myeloma	Stem Cell Exhaustion	Risk factors for unsuccessful peripheral blood stem cell harvesting using granulocyte-colony stimulating factor mobilization in patients with multiple myeloma.	22874435
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The aim of this study was to determine factors that influence unsuccessful peripheral blood stem cell (PBSC) harvesting in patients with multiple myeloma (MM).	22874435
Graft-vs-Host Disease	Stem Cell Exhaustion	Daily surveillance blood cultures were taken from patients treated with corticosteroids as part of their intensive chemotherapy or during graft-versus-host disease following hematopoietic stem cell transplantation during a 3-year period (2006-2009).	22875415
HD Term Type	Stem Cell Exhaustion	In this study, we aimed to assess the therapeutic potential of a human striatal neural stem cell line (STROC05) implanted in the R6/2 transgenic mouse model of HD.	22876937
Huntingtons Disease Pathway	Stem Cell Exhaustion	Implantation of undifferentiated and pre-differentiated human neural stem cells in the R6/2 transgenic mouse model of Huntington's disease.	22876937
Hematological Disease, Hemorrhage, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Patients aged 16-80 years, who were undergoing intensive chemotherapy for acute myeloid leukaemia or autologous haemopoietic stem-cell transplantation for haematological cancers, were randomly assigned via a computer-generated randomisation sequence to receive either platelet transfusion when bleeding occurred (therapeutic strategy) or when morning platelet counts were 10x10(9) per L or lower (prophylactic strategy).	22877506
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The therapeutic strategy could become a new standard of care after autologous stem-cell transplantation; however, prophylactic platelet transfusion should remain the standard for patients with acute myeloid leukaemia.	22877506
Neoplasms, Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	Aldehyde dehydrogenase 1 (ALDH1) has been suggested as a surrogate biomarker for cancer stem cells in breast cancer and other tumors.	22877687
Mucocutaneous candidiasis	Stem Cell Exhaustion	To investigate the morphology of the human eyelid margin and the presence of different cytokeratins, mucins and stem cell markers within the skin epithelium, mucocutaneous junction (MCJ) and palpebral conjunctiva.	22877886
Meibomian gland dysfunction, Dry Eye Syndromes	Stem Cell Exhaustion	Additionally, the knowledge of distribution of biomarkers like cytokeratins, mucins and stem cells can be useful in the investigation of MCJ disturbances which occur in several disorders of the meibomian glands and the lid epithelium in the course of dry eye syndrome and especially meibomian gland dysfunction.	22877886
Specialty Type - cancer	Stem Cell Exhaustion	Aldehyde dehydrogenase 1A1 (ALDH1A1) has been described as a cancer stem cell marker and as a regulator of cellular chemoresistance.	22878609
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Stem cell transplantation for paediatric patients with non-anaplastic peripheral T-cell lymphoma in Japan.	22881201
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Reports of non-anaplastic peripheral T-cell lymphoma (PTCL) in paediatric patients, especially results of stem cell transplantation (SCT), are relatively rare.	22881201
SERPINB3 wt Allele	Stem Cell Exhaustion	This study aimed to assess the value of the expression of poly(ADP-ribose) polymerase 1 (PARP-1), chromatin assembly factor-1 (CAF-1)/p60 and the stem cell markers CD133, CD166, CD44, CD44v6 and nestin as markers of outcome and progression-free survival in OSCC patients.	22882088
myocardial injury	Stem Cell Exhaustion	Myocardial injury recruits endothelial progenitor cells (EPCs) to the site of damage and stimulates their differentiation, contributing to myocardial tissue repair.	22882964
B-Cell Lymphomas	Stem Cell Exhaustion	Patients with diffuse large B cell lymphoma in partial response or stable disease after first-line R-CHOP: the prognostic value of the absolute lymphocyte count and impact of autologous stem cell transplantation.	22885989
Graft-vs-Host Disease	Stem Cell Exhaustion	Despite improvements in the prevention and treatment of graft-versus-host disease (GvHD) this allogeneic immune response is still one of major complications following allogeneic stem cell transplantation (SCT).	22889700
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Bone marrow mesenchymal stem cells in myelodysplastic syndromes: cytogenetic characterization.	22890308
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	This study compared genetic aberrations in hematopoietic cells (HCs) and mesenchymal stem cells of myelodysplastic syndrome (MDS-MSCs) patients.	22890308
Diarrhea, Gastrointestinal mucositis	Stem Cell Exhaustion	Clinical factors such as mucositis, diarrhea, and the early posttransplant period in hematopoietic stem cell transplant recipients were also associated with reduced posaconazole exposure (P < 0.01).	22890761
Traumatic	Stem Cell Exhaustion	Autologous bone marrow mesenchymal stem cell therapy in the subacute stage of traumatic brain injury by lumbar puncture.	22891928
Traumatic	Stem Cell Exhaustion	To explore the clinical therapeutic effects and safety of autologous bone marrow mesenchymal stem cell therapy for traumatic brain injury by lumbar puncture.	22891928
Disturbance in physical behavior, Traumatic, Lesion of brain	Stem Cell Exhaustion	A total of 97 patients (24 with persistent vegetative state and 73 with disturbance motor activity) who developed a complex cerebral lesion after traumatic brain injury received autologous bone marrow mesenchymal stem cell therapy voluntarily.	22891928
Motor Disorders, Traumatic	Stem Cell Exhaustion	This study suggests that the bone marrow stem cell therapy is safe and effective on patients with traumatic brain injury complications, such as persistent vegetative state and motor disorder, through lumbar puncture.	22891928
Multiple Myeloma	Stem Cell Exhaustion	A phase I dose-escalation trial of high-dose melphalan with palifermin for cytoprotection followed by autologous stem cell transplantation for patients with multiple myeloma with normal renal function.	22892551
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Melphalan 200 mg/m(2) is the standard conditioning regimen for patients with multiple myeloma (MM) with normal renal function (NRF) undergoing autologous stem cell transplant (ASCT).	22892551
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Donor compatibility and performance status affect outcome of allogeneic haematopoietic stem cell transplant in patients with relapsed or refractory acute myeloid leukaemia.	22893485
Specialty Type - cancer	Stem Cell Exhaustion	Chemoresistant cells, which potentially also display cancer stem cell (CSC) characteristics, can be isolated using the side population (SP) technique.	22894607
diabetic	Stem Cell Exhaustion	Far infra-red therapy promotes ischemia-induced angiogenesis in diabetic mice and restores high glucose-suppressed endothelial progenitor cell functions.	22894755
Stable chronic Graft vs Host Disease, Peripheral	Stem Cell Exhaustion	As BAFF increases murine B-cell metabolism and survival and maintains autoreactive B-cell clones, we performed ex vivo analyses of peripheral B cells from 51 patients who either had or did not have active cGVHD and were greater than 1 year from the time of allogeneic hematopoietic stem cell transplantation.	22896003
Multiple Myeloma	Stem Cell Exhaustion	Plerixafor appears to have effects on blood stem cell graft composition in myeloma patients.	22897584
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Cyclophosphamide (CY) combined with granulocyte-colony-stimulating factor (G-CSF) is commonly used to mobilize stem cells in multiple myeloma (MM).	22897584
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	We retrospectively analyzed data of 40 consecutive adult patients with relapsed and refractory peripheral T-cell lymphoma referred to our institution for consideration of second-line chemotherapy aiming for autologous stem cell transplant between January 1999 and December 2006.	22897731
Peripheral T-Cell Lymphoma, B-Cell Lymphomas	Stem Cell Exhaustion	Post-autologous stem cell transplant, 1-year progression-free survival was 20% (95% CI: 9-48) for patients with peripheral T-cell lymphoma and 47% (95% CI: 36-61) for patients with diffuse large B-cell lymphoma.	22897731
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Likely due to imbalances in risk factors at relapse, progression-free survival post-autologous stem cell transplant was inferior in the peripheral T-cell lymphoma group.	22897731
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Strategies aiming to maintain response duration post-autologous stem cell transplant could improve the outcome of patients with peripheral T-cell lymphoma.	22897731
Multiple Myeloma	Stem Cell Exhaustion	Intravenous busulfan and melphalan as a conditioning regimen for autologous stem cell transplantation in patients with newly diagnosed multiple myeloma: a matched comparison to a melphalan-only approach.	22897964
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Melphalan 200 mg/m(2) (MEL200) is the standard conditioning regimen administered to newly diagnosed patients with multiple myeloma (MM) undergoing autologous stem cell transplantation (ASCT).	22897964
BCR gene	Stem Cell Exhaustion	This study assesses the safety and efficacy of oral imatinib in association with a Berlin-Frankfurt-Munster intensive chemotherapy regimen and allogeneic stem-cell transplantation for paediatric patients with Philadelphia-chromosome-positive ALL.	22898679
Hereditary hemorrhagic telangiectasia, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Homoharringtonine (HHT), a valid drug for treating chronic myelogenous leukemia, has shown some effect on leukemic stem cells.	22898909
Neoplasms, Nerve Degeneration	Stem Cell Exhaustion	The Esophageal cancer-related gene-4 (Ecrg4) is a candidate tumor suppressor gene whose secreted protein product has been implicated in the development and progression of epithelial cancers, neuroprogenitor cell activation after central nervous system injury, cell senescence in neurodegeneration, and the survival of hematopoietic stem cells.	22899245
melanoma	Stem Cell Exhaustion	Recent studies have demonstrated strong expression of neural stem/progenitor cell markers nestin and SOX2 in melanoma.	22899289
Specialty Type - cancer	Stem Cell Exhaustion	These findings suggest that cancer stem-like cells/tumor-initiating cells are linked to more aggressive behavior of upper urinary tract urothelial cell carcinoma, supporting the current cancer stem cell hypothesis.	22899292
Prostate carcinoma	Stem Cell Exhaustion	p63 cytoplasmic aberrance is associated with high prostate cancer stem cell expression.	22901151
Prostate carcinoma	Stem Cell Exhaustion	Maintenance of normal stem cell or reserve cell populations in several epithelia including prostate has been shown to be regulated by p63 and alteration of p63 expression is considered to have an oncogenic role in prostate cancer.	22901151
Prostate carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	We hypothesize that the expression of cytoplasmic aberrance of p63 is associated with high ALDH1A1 expression as a cancer stem cell marker, thus leading to progression of prostate cancer.	22901151
Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	It has been suggested that stem cells in the prostate gland have a role in initiation, progression, and metastasis of cancer, although controversy continues to exist.	22901151
varicella zoster, herpesvirus 3, human, Communicable Diseases	Stem Cell Exhaustion	Severe disseminated varicella zoster virus (VZV) infection rarely occurs in patients who are not recipients of hematopoietic stem cell transplantation.	22903849
Graft-vs-Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic graft-versus-host disease (GVHD) is a common long-term complication of allogeneic hematopoietic stem-cell transplantation (HSCT), and is responsible for morbidity, mortality and a decrease in quality of life of patients after SCT.	22903864
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	To evaluate the long-term effects of peripheral blood stem cell therapy in myocardial infarction (MI) patients.	22904565
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Five-year results of intracoronary infusion of the mobilized peripheral blood stem cells by granulocyte colony-stimulating factor in patients with myocardial infarction.	22904565
Acute Promyelocytic Leukemia, Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	Promyelocytic leukemia protein (PML) was originally identified as a tumor suppressor but has been recently shown to have the ability to control stem cell function in multiple tissues including malignancies.	22906876
Central neuroblastoma	Stem Cell Exhaustion	The adult stem cell maintenance factor and Polycomb group protein, Bmi1 (B-cell-specific Moloney murine leukemia virus integration site), had a critical role at neuroblastoma initiation in the model, by repressing p53 responses in precursor cells.	22907436
Restenosis	Stem Cell Exhaustion	These patients correspond to a class of fragile subjects at high risk of cardiovascular events, and new predictors of restenosis should be contemplated, such as of eNOS polymorphism, (rs753482-A>C SNP) and circulating endothelial progenitor cells.	22907764
Primary Myelofibrosis	Stem Cell Exhaustion	Thirty myelofibrosis patients (21 males, nine females) with relapse (n = 27) or graft-rejection (n = 3) after dose-reduced allografting underwent a salvage strategy including donor lymphocyte infusions (DLIs) and/or second allogeneic haematopoietic stem cell transplantation (HSCT).	22909192
Aplastic anemia, idiopathic, Anhidrosis	Stem Cell Exhaustion	A 38-year-old man with idiopathic autoimmune aplastic anemia developed permanent diffuse skin and hair whitening and generalized anhidrosis after a successful allogeneic hematopoietic stem cell transplant.	22911189
Graft-vs-Host Disease	Stem Cell Exhaustion	Acute GVHD is a strong predictor of full donor CD3+ T cell chimerism after reduced intensity conditioning allogeneic stem cell transplantation.	22911907
platelet dysfunction, Congenital anemia, Decreased platelet count	Stem Cell Exhaustion	Severe congenital anemia (hemoglobin 72 g/L), thrombocytopenia (42xG/L) and profound platelet dysfunction led a stem cell defect to be suspected.	22915449
Amyotrophic Lateral Sclerosis	Stem Cell Exhaustion	Human neural stem cell replacement therapy for amyotrophic lateral sclerosis by spinal transplantation.	22916141
MPV17 gene	Stem Cell Exhaustion	Activated parietal epithelial cells are proposed to contribute to pathogenesis of glomerulosclerosis and may serve as stem cells that can transition to podocytes.	22917699
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndrome.	22919028
Virus Diseases	Stem Cell Exhaustion	Timeline, epidemiology, and risk factors for bacterial, fungal, and viral infections in children and adolescents after allogeneic hematopoietic stem cell transplantation.	22922523
Graft-vs-Host Disease, Stable chronic Graft vs Host Disease, Bacterial Infections, Acute GVH disease	Stem Cell Exhaustion	Era of transplantation (0-30 days), peripheral blood stem cell product, acute graft-versus-host disease (aGVHD; 31-100 days), and chronic GVHD (cGVHD; 101-730 days) were associated with higher risk for bacterial infections at the respective time periods.	22922523
Neoplasms	Stem Cell Exhaustion	Recent research suggests that tissue stem cells and the self renewal transcription factor, octamer-binding transcription factor 4 (Oct4), could be involved in the development of certain tumors.	22922943
Specialty Type - cancer	Stem Cell Exhaustion	In this study, we investigated the effects of ROS on cancer stem cells, in colorectal cancer cells.	22923033
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	It was previously shown that chronic myeloid leukemia (CML) patients transplanted with peripheral blood progenitor cells (PBPC) from HLA-C allele-matched donors had better clinical outcome when lacking the HLA-C-encoded KIR epitope C2.	22923051
Malignant tumor of colon	Stem Cell Exhaustion	CD44 is a ubiquitously expressed cell adhesion molecule and also a potential cell surface marker on colon cancer stem cells.	22923071
Retinoblastoma	Stem Cell Exhaustion	A 6-year-old girl underwent genetic testing after developing unilateral retinoblastoma subsequent to treatment (surgery, chemotherapy, and stem-cell rescue) for a sPNET found at 1 year of age.	22924820
allergic inflammation	Stem Cell Exhaustion	Hematopoietic progenitor cells, especially those committed to the Eo/B lineage, are known to contribute to allergic inflammation.	22925320
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We verified that in BCR-ABL-positive progenitor cells from a CML patient and in K562 cells pSTAT5 is cytoplasmic.	22926520
Sjogrens Syndrome	Stem Cell Exhaustion	Allogeneic mesenchymal stem cell treatment alleviates experimental and clinical Sjogren syndrome.	22927248
Autoimmune state	Stem Cell Exhaustion	Importantly, treatment with mesenchymal stem cells (MSCs) suppressed autoimmunity and restored salivary gland secretory function in both mouse models and SS patients.	22927248
Hematologic Neoplasms	Stem Cell Exhaustion	We conducted an adaptive randomized trial to evaluate the effectiveness of an intermittent dosing schedule of ribavirin versus that of a continuous dosing schedule of ribavirin in preventing RSV LRTIs in 50 hematopoietic stem cell transplant recipients or patients with hematologic malignancies.	22927454
Acute Radiation Syndrome, Hematological Disease	Stem Cell Exhaustion	Long-term hematopoietic stem cell damage in a murine model of the hematopoietic syndrome of the acute radiation syndrome.	22929468
Bone Marrow	Stem Cell Exhaustion	Residual bone marrow damage (RBMD) persists for years following exposure to radiation and is believed to be due to decreased self-renewal potential of radiation-damaged hematopoietic stem cells (HSC).	22929468
Graft-vs-Host Disease, Azoospermia	Stem Cell Exhaustion	Ongoing graft-versus-host disease is a risk factor for azoospermia after allogeneic hematopoietic stem cell transplantation: a survey of the Late Effects Working Party of the European Group for Blood and Marrow Transplantation.	22929982
Spermatogenesis, Infertility	Stem Cell Exhaustion	The aim of this study was to assess the degree of spermatogenesis defects in sperm analysis in long-term male survivors after allogeneic hematopoietic stem cell transplantation in order to identify the risk factors related to potential infertility after hematopoietic stem cell transplantation and to provide data on longitudinal sperm recovery after hematopoietic stem cell transplantation.	22929982
Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	Using these cell lines, we investigated the involvement of the epithelial-mesenchymal transition (EMT) and cancer stem cell (CSCs) in AdCC metastasis by real-time RT-PCR for EMT related genes and stem cell markers.	22931165
Malignant Neoplasms, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Of the cancers treated with allogeneic hematopoietic stem-cell transplantation (HSCT), acute myeloid leukemia (AML) is most sensitive to natural killer (NK)-cell reactivity.	22931314
GDC Disease Response Terminology, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We assessed clinical data, HLA genotyping results, and donor cell lines or genomic DNA for 1277 patients with AML who had received hematopoietic stem-cell transplants from unrelated donors matched for HLA-A, B, C, DR, and DQ or with a single mismatch.	22931314
Thalassemia	Stem Cell Exhaustion	HLA-matched family hematopoetic stem cell transplantation in children with beta thalassemia major: the experience of the Turkish Pediatric Bone Marrow Transplantation Group.	22931438
Specialty Type - cancer, Glioblastoma	Stem Cell Exhaustion	Like glioblastomas, AT/RTs contain brain cancer stem cells (CSCs) that suppress the immunity of patients and are resistant to conventional chemotherapy and radiation therapy.	22931701
Agenesis	Stem Cell Exhaustion	Chronic TRF1 deletion results in increased DNA damage and cellular senescence, but not increased apoptosis, in BM progenitor cells, leading to severe aplasia.	22932806
Fulminant Hepatitis, Infection, Immunocompromised Host	Stem Cell Exhaustion	Although in profoundly immunocompromised hosts after solid organ or stem cell transplantation, adenovirus may cause fulminant hepatitis or other life-threatening infections, this is a rare complication in patients receiving standard chemotherapy.	22935664
Childhood Breast Carcinoma	Stem Cell Exhaustion	The expression status of CD74 in breast cancer stem cells and its clinical implications was evaluated in order to lay a foundation for managing breast cancer.	22935920
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	TdT expression in acute myeloid leukemia with minimal differentiation is associated with distinctive clinicopathological features and better overall survival following stem cell transplantation.	22936064
Breast Carcinoma	Stem Cell Exhaustion	High expression of stem cell marker ALDH1 is associated with reduced BRCA1 in invasive breast carcinomas.	22938492
Breast Carcinoma, Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSC) have been described in a variety of malignancies, including breast carcinomas.	22938492
Childhood Breast Carcinoma	Stem Cell Exhaustion	Among several markers, aldehyde dehydrogenase 1 (ALDH1) has been identified as reliable for breast cancer stem cells.	22938492
Specialty Type - cancer	Stem Cell Exhaustion	Therefore, ALDH1 positive (cancer stem) cells with reduced BRCA1 phenotype may indicate a subset of patients for whom specific targeting of the CSC marker ALDH1 and more aggressive adjuvant treatment is appropriate.	22938492
B-Cell Lymphomas	Stem Cell Exhaustion	Phase II trial of 131-Iodine tositumomab with high-dose chemotherapy and autologous stem cell transplantation for relapsed diffuse large B cell lymphoma.	22940055
Primary Cutaneous B-Cell Non-Hodgkin Lymphoma, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	The purpose of this study was to evaluate the standard outpatient dose of 131-Iodine tositumomab (75 cGy) combined with high-dose carmustine, etoposide, cytarabine, and melphalan (BEAM) followed by autologous stem cell rescue for the treatment of chemotherapy-sensitive relapsed or refractory, or high-risk first complete remission (CR) patients with diffuse large B cell non-Hodgkin's lymphoma (DLBCL).	22940055
Wernicke Encephalopathy, Upbeat central vestibular nystagmus, Leukemia, Myelocytic, Acute, Nystagmus, End-Position	Stem Cell Exhaustion	A 33-year-old woman with Wernicke's encephalopathy (WE) due to poor oral intake after allogeneic stem cell transplantation for acute myeloid leukemia showed a sequential development of bilateral gaze-evoked nystagmus (GEN), rightward gaze palsy, and upbeat nystagmus.	22940074
Fatigue, Specialty Type - cancer	Stem Cell Exhaustion	Measurements included the Profile of Mood States fatigue scale, Functional Assessment of Cancer Therapy-Fatigue, ActiGraph(r) recordings, 6-Minute Walk Test, and hemoglobin levels at baseline and before and after stem cell collection.	22940511
Dilated Cardiomyopathy Pathway	Stem Cell Exhaustion	[Comparative study on the efficacy of intracoronary infusion with various types of autologous bone marrow stem cells for patients with dilated cardiomyopathy].	22943685
Doctor of Chiropractic, Dilated Cardiomyopathy Pathway	Stem Cell Exhaustion	To compare the effects of intracoronary infusion of mononuclear stem cells (MNCs) or mesenchymal stem cells (MSCs) in patients with dilated cardiomyopathy (DCM).	22943685
Doctor of Chiropractic	Stem Cell Exhaustion	Intracoronary bone marrow stem cells transplantation is safe and effective for DCM patients while the efficacy of MSCs and MNCs transplantation is comparable.	22943685
Febrile Neutropenia	Stem Cell Exhaustion	Drug interactions between micafungin at high doses and cyclosporine A in febrile neutropenia patients after allogeneic hematopoietic stem cell transplantation.	22943928
Hemorrhagic cystitis	Stem Cell Exhaustion	Risk factors for and prognosis of hemorrhagic cystitis after allogeneic stem cell transplantation: retrospective analysis in a single institution.	22944099
CLTC gene, Hemorrhagic cystitis	Stem Cell Exhaustion	Hemorrhagic cystitis (HC) is a major complication after allogeneic stem cell transplantation (allo-SCT) and can be life threatening.	22944099
Papillary Renal Cell Carcinoma	Stem Cell Exhaustion	Expression of stem-cell markers OCT-4 and CD133: important prognostic factors in papillary renal cell carcinoma.	22944295
Papillary Renal Cell Carcinoma	Stem Cell Exhaustion	To the best of our knowledge, the prognostic significance of the expression of stem cell markers, OCT-4 and CD133, has not yet been studied in papillary renal cell carcinoma.	22944295
Papillary Renal Cell Carcinoma	Stem Cell Exhaustion	These results showed that the expression of stem cell markers, OCT-4 and CD133, may serve, respectively, as a poor and favorable prognostic marker, in papillary renal cell carcinoma.	22944295
Neurotoxicity Syndromes, Impaired cognition	Stem Cell Exhaustion	Owing to its neurotoxicity, allogeneic hematopoietic stem cell transplantation (HSCT) carries risks for cognitive impairment.	22945857
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In this study, we report that leukemia stem cell function in xenotransplant models of acute myeloid leukemia (AML) depends on SIRPa-mediated inhibition of macrophages through engagement with its ligand CD47.	22945919
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Disruption of SIRPa signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts.	22945919
Specialty Type - cancer, Neoplasms, Malignant Neoplasms, leukemia	Stem Cell Exhaustion	Moreover, the existence of subclonal genetic and functional diversity in some human cancers such as leukemia underscores the importance of defining tumor surveillance mechanisms that effectively target the disease-sustaining cancer stem cells in addition to bulk cells.	22945919
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We generated mice expressing SIRPa variants with differential ability to bind human CD47 and demonstrated that macrophage-mediated phagocytosis and clearance of AML stem cells depend on absent SIRPa signaling.	22945919
Degenerative polyarthritis	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) are self-renewing, multipotent cells that could potentially be used to repair injured cartilage in diseases such as osteoarthritis (OA).	22947769
Specialty Type - cancer, Pancreatic carcinoma	Stem Cell Exhaustion	Pancreatic carcinoma cell lines reflect frequency and variability of cancer stem cell markers in clinical tissue.	22948659
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells (CSCs) are thought to be responsible for progression and therapy resistance.	22948659
Malignant Neoplasms	Stem Cell Exhaustion	Circulating endothelial progenitor cells (cEPCs) as recruited to the angiogenic vascular system of malignant tumors have been proposed as a biomarker in malignancies.	22948772
Myocardial Ischemia	Stem Cell Exhaustion	Mesenchymal stem cell (MSC) transplantation has been proposed as a potential therapeutic approach for ischemic heart disease, but the regenerative capacity of these cells decreases with age.	22950427
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Tissue inhibitor of matrix metalloproteinase-3 or vascular endothelial growth factor transfection of aged human mesenchymal stem cells enhances cell therapy after myocardial infarction.	22950427
Inflammation, Metastatic hepatocellular carcinoma	Stem Cell Exhaustion	Mesenchymal stem cells in inflammation microenvironment accelerates hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition.	22952657
Tissue injury, Inflammation	Stem Cell Exhaustion	In response to inflammation, mesenchymal stem cells (MSCs) are known to migrate to tissue injury sites to participate in immune modulation, tissue remodeling and wound healing.	22952657
Disease, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Cytopenia, Hypercellular bone marrow	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are clonal stem cell disorders which frequently show a hypercellular dysplastic bone marrow (BM) associated with inefficient hematopoiesis and peripheral cytopenias due to increased apoptosis and maturation blockades.	22952954
Toxic effect, Lymphoma	Stem Cell Exhaustion	This study aimed to evaluate the efficacy and toxicity of radioimmunotherapy (RIT) in recurrent lymphoma after hematopoietic stem cell transplantation (HSCT).	22955069
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Extramedullary relapse of acute myeloid leukemia (AML) after stem-cell transplant is very rare and often remains a diagnostic challenge.	22955081
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Long-term follow-up of reduced-intensity allogeneic stem cell transplantation for chronic lymphocytic leukemia: prognostic model to predict outcome.	22955330
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Chronic lymphocytic leukemia (CLL) remains incurable with chemoimmunotherapy, and allogeneic hematopoietic stem cell transplantation (HSCT) offers the potential for cure.	22955330
Intermittent Claudication	Stem Cell Exhaustion	Exercise training in intermittent claudication: effects on antioxidant genes, inflammatory mediators and proangiogenic progenitor cells.	22955572
Malignant Glioma	Stem Cell Exhaustion	Increased age of transformed mouse neural progenitor/stem cells recapitulates age-dependent clinical features of human glioma malignancy.	22958206
Glioblastoma Multiforme Pathway, Malignant Glioma	Stem Cell Exhaustion	However, the adverse association of clinical course with aging is rarely considered in animal glioma models, impeding delineation of the relative importance of organismal versus progenitor cell aging in the genesis of glioma malignancy.	22958206
Glioma, Malignant Glioma	Stem Cell Exhaustion	Our study provides strong evidence that progenitor cell aging is responsible for promoting the hallmarks of age-dependent glioma malignancy and that consideration of progenitor aging will facilitate development of physiologically and clinically relevant animal models of human gliomas.	22958206
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	To address this limitation, we implanted transformed neural stem/progenitor cells (NSPCs), the presumed cells of glioma origin, from 3- and 18-month-old mice into 3- and 20-month host animals.	22958206
Glioblastoma Multiforme Pathway, Hypoxia	Stem Cell Exhaustion	Greater tolerance to hypoxia in older progenitor cells, as evidenced by elevated HIF-1 promoter reporter activity and hypoxia response gene (HRG) expression, mirrors the upregulation of HRGs in cohorts of older vs. younger glioma patients revealed by analysis of gene expression databases, suggesting that differential response to hypoxic stress may underlie age-dependent differences in invasion, genomic instability, and treatment resistance.	22958206
Mucositis following radiation therapy	Stem Cell Exhaustion	mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.	22958932
Mucositis following radiation therapy	Stem Cell Exhaustion	mTOR inhibition also protects from the loss of proliferative basal epithelial stem cells upon ionizing radiation in vivo, thereby preserving the integrity of the oral mucosa and protecting from radiation-induced mucositis.	22958932
leukemia	Stem Cell Exhaustion	Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression.	22958933
Neoplasms	Stem Cell Exhaustion	Developmental changes in key signaling pathways therefore confer temporal changes upon stem cell self-renewal and tumor suppressor mechanisms.	22958933
Pneumonitis, CTCAE	Stem Cell Exhaustion	Pneumonitis post-haematopoeitic stem cell transplant - cytopathology clinches diagnosis.	22959064
CLTC gene, Cystitis	Stem Cell Exhaustion	BKV reactivation is implicated in late onset haemorrhagic cystitis (HC) post Haematopoietic Stem Cell Transplant (HSCT).	22959064
Neoplasms	Stem Cell Exhaustion	Notably, INK4-ARF is actively silenced en bloc in embryonic, fetal, and adult stem cells but becomes poised to respond to oncogenic stress signals as stem cells lose their self-renewal capacity and differentiate, thereby providing a potent barrier to tumor formation.	22960768
Hodgkin Disease, Failure	Stem Cell Exhaustion	FDA granted accelerated approval of brentuximab vedotin for the treatment of patients with Hodgkin lymphoma after failure of autologous stem cell transplantation (ASCT) or after failure of at least two prior multiagent chemotherapy regimens in patients who are not ASCT candidates, and for the treatment of patients with sALCL after failure of at least one prior multiagent chemotherapy regimen.	22962441
Colorectal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Expression levels of CD133, a cancer stem cell marker, and of the a-subunit of the dystroglycan (a-DG) complex, have been previously reported to be altered in colorectal cancers.	22964035
Rhinosinusitis	Stem Cell Exhaustion	Hematopoietic stem cell transplantation and rhinosinusitis: the utility of screening sinus computed tomography.	22965703
Lupus Erythematosus, Systemic	Stem Cell Exhaustion	Gene expression profile reveals abnormalities of multiple signaling pathways in mesenchymal stem cell derived from patients with systemic lupus erythematosus.	22966240
Lupus Erythematosus, Encephalitis, St. Louis	Stem Cell Exhaustion	We aimed to compare bone-marrow-derived mesenchymal stem cells (BMMSCs) between systemic lupus erythematosus (SLE) and normal controls by means of cDNA microarray, immunohistochemistry, immunofluorescence, and immunoblotting.	22966240
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Early onset MDS present markedly decreased hematopoietic progenitor cells (HPC), and particularly in erythroid progenitors extensively and severely.	22967409
HER2-positive carcinoma of breast	Stem Cell Exhaustion	Epithelial-mesenchymal transition and stem cell markers in patients with HER2-positive metastatic breast cancer.	22973057
mecarzole, Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	In this prospective study, we assessed the gene transcripts of epithelial-to-mesenchymal transition-inducing transcription factors (EMT-TF) and cancer stem cell (CSC) features in patients with HER2(+) metastatic breast cancer (MBC).	22973057
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The incorporation of high-dose therapy/autologous stem cell transplantation (HDT/ASCT) and novel agents has significantly improved survival in patients with multiple myeloma (MM), but whether this improvement also benefits patients harboring poor prognostic features, such as nonhyperdiploid MM (NH-MM) and a high proliferation index, remains largely unknown.	22974582
Osteosarcoma, Central neuroblastoma	Stem Cell Exhaustion	We present a case of chest wall osteosarcoma that developed in a 14-year-old boy 7 years after completion of chemotherapy, autologous peripheral blood stem cell transplantation, radiation, and resection for stage 3, high-risk neuroblastoma.	22974636
B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1	Stem Cell Exhaustion	The patient received allogenic peripheral blood stem cell transplantation from a haploidentical son against Philadelphia chromosome-positive acute lymphocytic leukemia.	22975560
Senile cardiac amyloidosis	Stem Cell Exhaustion	[Clinical analysis of autologous stem cell transplantation for nine cases of cardiac amyloidosis].	22975774
Treatment related secondary malignancy, Amyloidosis	Stem Cell Exhaustion	High-dose melphalan (MEL) with stem cell transplantation (HDM/SCT) is an effective treatment for AL amyloidosis, but patients with cardiac involvement are ineligible because of high therapy-related mortality.	22975774
Encephalopathy, CTCAE 5.0, Brain Abscess, Toxoplasmosis	Stem Cell Exhaustion	Toxoplasmosis after allogeneic hematopoietic stem cell transplantation (HSCT) generally manifests as encephalopathy or brain abscess; however, disseminated disease has been sporadically reported.	22975819
TCL4 gene, Pustulosis of Palms and Soles	Stem Cell Exhaustion	[Alleviation of palmoplantar pustulosis associated with adult T cell leukemia/lymphoma after allogeneic hematopoietic stem cell transplantation].	22975820
Adult T-Cell Lymphoma/Leukemia	Stem Cell Exhaustion	For ATLL in partial remission, we performed allogeneic peripheral blood stem cell transplantation (allo-PBSCT) from a related donor (HTLV-1-negative) with a conditioning regimen consisting of fludarabine, melphalan, and total body irradiation with 3 Gy in February, 2010.	22975820
Aplastic Anemia	Stem Cell Exhaustion	Outcome of allogeneic haematopoietic stem cell transplantation in aplastic anaemia.	22980607
Aplastic Anemia	Stem Cell Exhaustion	To analyze factors associated with survival, rejection and graft versus host disease in aplastic anaemia patients undergoing allogeneic haematopoietic stem cell transplantation (SCT) from HLA matched sibling donors.	22980607
Aplastic Anemia	Stem Cell Exhaustion	Consecutive aplastic anaemia (AA) patients undergoing haematopoietic stem cell transplantation from HLA-matched sibling donors at this centre were included in this study.	22980607
Malignant neoplasm of ovary	Stem Cell Exhaustion	Finally, xenotransplantation of human induced pluripotent stem cells, ovarian cancer cells, and hepatocytes shows that SCID and FSG rats can act as hosts for xenogeneic tissue grafts and stem cell transplantation and may be useful for preclinical testing of new drugs.	22981234
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Superior long-term outcome of patients with early transformation of non-Hodgkin lymphoma undergoing stem cell transplantation.	22981964
Vascular System Injuries	Stem Cell Exhaustion	Respective abundance of circulating endothelial cells (CEC) and endothelial progenitor cells (EPC) might reflect the balance between vascular injury and repair and potentially serve as biomarkers of the disease.	22983452
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Plerixafor and granulocyte colony-stimulating factor for first-line steady-state autologous peripheral blood stem cell mobilization in lymphoma and multiple myeloma: results of the prospective PREDICT trial.	22983579
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	In Europe, the combination of plerixafor + granulocyte colony-stimulating factor is approved for the mobilization of hematopoietic stem cells for autologous transplantation in patients with lymphoma and myeloma whose cells mobilize poorly.	22983579
Hodgkin Disease, Lymphoma, Non-Hodgkin, Multiple Myeloma	Stem Cell Exhaustion	The combination of plerixafor + granulocyte colony-stimulating factor was used to mobilize hematopoietic stem cells in 118 patients (90 with myeloma, 25 with non-Hodgkin's lymphoma, 3 with Hodgkin's disease).	22983579
Lymphoma, Non-Hodgkin, Toxic effect, Multiple Myeloma	Stem Cell Exhaustion	In this prospective, multicenter European study, mobilization with plerixafor + granulocyte colony-stimulating factor allowed the majority of patients with myeloma or non-Hodgkin's lymphoma to undergo transplantation with minimal toxicity, providing further data supporting the safety and efficacy of plerixafor + granulocyte colony-stimulating factor for front-line mobilization of hematopoietic stem cells in patients with non-Hodgkin's lymphoma or myeloma.	22983579
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Influence of molecular subgroups on outcome of acute myeloid leukemia with normal karyotype in 141 patients undergoing salvage allogeneic stem cell transplantation in primary induction failure or beyond first relapse.	22983588
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	To evaluate the role of molecular subgroups of acute myeloid leukemia with normal karyotype after allogeneic stem cell transplantation beyond first complete remission, we analyzed the data from 141 consecutive adults (median age: 51.0 years, range 18.4-69.3 years) who had received an allogeneic transplant either in primary induction failure or beyond first complete remission.	22983588
Ischemic stroke	Stem Cell Exhaustion	In order to detect possible neural stem or progenitor cells in CVOs of the human brain, we analysed post mortem human brain tissue from patients without neuropathological changes (n = 16) and brains from patients with ischaemic stroke (n = 16).	22985410
Neoplasms, Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	Transcription factors associated with epithelial-mesenchymal transition and cancer stem cells in the tumor centre and margin of invasive breast cancer.	22985790
Specialty Type - cancer	Stem Cell Exhaustion	Recently, features of EMT were shown to be linked to cells with tumor-founding capability, so- called cancer stem cells (CSC).	22985790
Hyperglycemia, Acute GVH disease	Stem Cell Exhaustion	Severe hyperglycemia immediately after allogeneic hematopoietic stem-cell transplantation is predictive of acute graft-versus-host disease.	22987342
Graft-vs-Host Disease, Hyperglycemia, Acute GVH disease	Stem Cell Exhaustion	Stress hyperglycemia and acute graft-versus-host disease (GVHD), the major early complication of hematopoietic stem cell transplantation (HSCT), are both associated with excessive release of inflammatory cytokines.	22987342
Acute leukemia	Stem Cell Exhaustion	We studied nondiabetic adult recipients of human leukocyte antigen-matched HSCT (peripheral blood stem cells) for acute leukemia.	22987342
Multiple Myeloma	Stem Cell Exhaustion	The introduction of novel agents (thalidomide, bortezomib and lenalidomide) in the frontline therapy of multiple myeloma has markedly improved the outcome both in younger patients who are candidates for high-dose therapy plus autologous stem-cell transplantation (HDT/ASCT) and in elderly patients.	22987987
Neoplasms, Malignant neoplasm of ovary, Specialty Type - cancer, ovarian neoplasm	Stem Cell Exhaustion	We investigated plasma levels of selected hematopoietic cytokines: stem cell factor (SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), and macrophage colony-stimulating factor (M-CSF) and the tumor marker cancer antigen (CA 125) in epithelial ovarian cancer patients as compared with control groups: benign ovarian tumor patients (cysts) and healthy subjects.	22988839
Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis.	22990013
Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	Hemophagocytic lymphohistiocytosis (HLH) is characterized by deregulated engulfment of hematopoietic stem cells (HSCs) by BM macrophages, which are activated presumably by systemic inflammatory hypercytokinemia.	22990013
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	MRI-based liver iron content predicts for nonrelapse mortality in MDS and AML patients undergoing allogeneic stem cell transplantation.	22991415
Liver carcinoma, Specialty Type - cancer, Hollings Cancer Center	Stem Cell Exhaustion	Epithelial cell adhesion molecule (EpCAM) has been proposed as a marker for cancer stem cells in human hepatocellular carcinoma (HCC).	22993038
Neoplasms	Stem Cell Exhaustion	In this Opinion article, we discuss recent reports that suggest unique and only partially understood mechanisms behind this paradox, including tumour repression, anti-angiogenic effects and stem cell ageing and availability.	22996602
Pneumonia	Stem Cell Exhaustion	Fatal BK virus pneumonia following stem cell transplantation.	22998078
Pneumonia, Acute lymphocytic leukemia	Stem Cell Exhaustion	We report the case of a 39-year-old male patient who died of severe BK virus (BKV) pneumonia 168 days after hematopoietic stem cell transplantation (HSCT) for acute lymphoblastic leukemia.	22998078
Coronary Arteriosclerosis	Stem Cell Exhaustion	The number of circulating endothelial progenitor cells (EPCs) is considered to be a surrogate marker for coronary artery disease (CAD).	23000960
Ocular surface disease	Stem Cell Exhaustion	A 9-year-old girl with severe unilateral ocular surface disease due to limbal stem cell deficiency following chemical injury underwent autologous cultivated limbal epithelial transplantation (CLET) twice in her right eye that failed to improve the condition of the ocular surface.	23001100
Communicable Diseases	Stem Cell Exhaustion	Increased infection rate after preemptive rituximab treatment for Epstein-Barr virus reactivation after allogeneic hematopoietic stem-cell transplantation.	23001354
Lymphoproliferative Disorders, Immunologic Deficiency Syndromes	Stem Cell Exhaustion	Preemptive rituximab (R) treatment decreases the incidence of Epstein-Barr virus (EBV) posttransplantation lymphoproliferative disease, but the extent of immune deficiency related to R in patients who received allogeneic hematopoietic stem-cell transplantation is unclear.	23001354
Acute GVH disease	Stem Cell Exhaustion	Fifty-two of them could be matched with controls (not receiving R) according to administration of antithymoglobulin, stem-cell source and donor type, age and grade of acute graft-versus-host disease.	23001354
Multiple Organ Failure	Stem Cell Exhaustion	HLH may be cured by immunosuppressive therapy and eventual stem cell transplantation but rapid disease progression to multi-organ failure results in a high mortality.	23005894
T-Cell Prolymphocytic Leukemia	Stem Cell Exhaustion	In this paper, we report a case of a 61-year-old female who underwent nonmyeloablative allogenic stem cell transplantation for T-cell prolymphocytic leukemia and subsequently developed biopsy proven minimal change disease shortly after cessation of her immunosuppression therapy.	23006339
Multiple Myeloma	Stem Cell Exhaustion	Serologic response to a 23-valent pneumococcal vaccine administered prior to autologous stem cell transplantation in patients with multiple myeloma.	23009118
Multiple Myeloma	Stem Cell Exhaustion	We retrospectively investigated the response of a 23-valent polysaccharide-based pneumococcal vaccine in 60 patients with multiple myeloma administered prior to autologous stem cell transplantation (ASCT).	23009118
Chronic granulomatous disease	Stem Cell Exhaustion	Health related quality of life and emotional health in children with chronic granulomatous disease: a comparison of those managed conservatively with those that have undergone haematopoietic stem cell transplant.	23011479
Chronic granulomatous disease	Stem Cell Exhaustion	Haematopoietic stem cell transplant (HSCT) can cure CGD.	23011479
Play, Communicable Diseases	Stem Cell Exhaustion	Delays in immune recovery after allogeneic hematopoietic stem cell transplantation (allo-HSCT) are associated with increased risks of infection and relapse.	23012326
BCR gene, Leukemia, Myelocytic, Acute, Multiple Myeloma, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Five patients (2 AML, 1 ALL, 1 accelerated-phase CML, and 1 myeloma) were treated with autologous or allogeneic stem-cell transplantation.	23014520
Amyloidosis	Stem Cell Exhaustion	Bortezomib and dexamethasone consolidation following risk-adapted melphalan and stem cell transplantation for patients with newly diagnosed light-chain amyloidosis.	23014566
Prediabetes syndrome, diabetic	Stem Cell Exhaustion	Patients with an HbA1c in the prediabetic and diabetic range have higher numbers of circulating cells with osteogenic and endothelial progenitor cell markers.	23015657
Vascular calcification, Disorder of eye due to diabetes mellitus	Stem Cell Exhaustion	Vascular calcification, an important feature of diabetic vasculopathy, is an active process potentially mediated by endothelial progenitor cells (EPCs) coexpressing the osteoblastic marker osteocalcin (OCN).	23015657
Skin Erosion	Stem Cell Exhaustion	To change the current amelioration of disease into a full cure, we propose to (i) increase safety as well as efficacy of haematopoietic cell transplant (HCT) using co-infusion of mesenchymal stromal/stem cells with haematopoietic stem cells and non-myeloablative conditioning for transplant; (ii) optimize homing of donor cells into the skin erosions in animal models of EB; and (iii) discover and test new drugs for EB therapy using patient-specific induced pluripotent stem cells.	23016552
Inflammation, Coronary Arteriosclerosis	Stem Cell Exhaustion	Inflammation and circulating endothelial progenitor cells in patients with coronary artery disease and residual platelet reactivity.	23018312
Ischemia	Stem Cell Exhaustion	A long-term outcome of therapeutic angiogenesis by transplantation of peripheral blood stem cells in critical limb ischemia after interventional revascularization.	23019056
Myeloid-Lymphoid Leukemia Protein	Stem Cell Exhaustion	Our data demonstrate that NPM1-mutated CN-AML originates in an early stem cell with both lymphoid and myeloid differentiation potential.	23020761
Hematologic Neoplasms	Stem Cell Exhaustion	Donor lymphocyte infusions (DLI) can induce remission in patients with hematologic malignancies who relapse after allogeneic stem cell transplantation.	23022128
Graft-vs-Host Disease	Stem Cell Exhaustion	Association of disparities in known minor histocompatibility antigens with relapse-free survival and graft-versus-host disease after allogeneic stem cell transplantation.	23022467
Hematologic Neoplasms	Stem Cell Exhaustion	Allogeneic stem cell transplantation (allo-SCT) can induce remission in patients with hematologic malignancies due to graft-versus-tumor (GVT) responses.	23022467
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cell behavior is thought to be largely determined by intrinsic properties and by regulatory signals provided by the microenvironment.	23023702
Hematopoietic Neoplasms, Primary Myelofibrosis	Stem Cell Exhaustion	Spleens of myelofibrosis patients contain malignant hematopoietic stem cells.	23023702
Neuronal and mixed neuronal-glial tumor	Stem Cell Exhaustion	Olig2-positive cells in glioneuronal tumors show both glial and neuronal characters: the implication of a common progenitor cell?	23025580
Chordoma, Scoliosis, unspecified	Stem Cell Exhaustion	Non-DD cells were collected from 1 donor (scoliosis) and chordoma tissue was obtained from (positive control, stem cell markers) 2 donors.	23025667
Impaired T cell function	Stem Cell Exhaustion	The goal of this study was to uncover age-dependent mechanisms of stem cell dysfunction and to investigate possible means to restore the cellular function.	23026201
Graft-vs-Host Disease, Muscle Cramp, Neuropathy	Stem Cell Exhaustion	Muscle cramps and neuropathies in patients with allogeneic hematopoietic stem cell transplantation and graft-versus-host disease.	23028681
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GVHD) is an immune-mediated multisystemic disorder and the leading cause of morbidity after allogeneic hematopoietic stem cell transplantation.	23028681
Muscle Cramp, Polyneuropathy	Stem Cell Exhaustion	Median onset of polyneuropathy and muscle cramps was 6 and 9 months after allogeneic hematopoietic stem cell transplantation, respectively.	23028681
Osteoporosis	Stem Cell Exhaustion	The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors.	23028809
Osteoporotic Fractures	Stem Cell Exhaustion	These candidate genes indicate intrinsic deficiencies in self-renewal and differentiation potential in osteoporotic stem cells.	23028809
Osteoporotic Fractures	Stem Cell Exhaustion	We also compared both hMSC-OP and non-osteoporotic hMSC-old of elderly donors to hMSC of ~30 years younger donors and found that the transcriptional changes acquired between the sixth and the ninth decade of life differed widely between osteoporotic and non-osteoporotic stem cells.	23028809
Neutropenia	Stem Cell Exhaustion	The use of intravenous antibiotics at the onset of neutropenia in patients receiving outpatient-based hematopoietic stem cell transplants.	23029441
Neutropenia, Bacterial Infections	Stem Cell Exhaustion	Empirical antibiotics at the onset of febrile neutropenia are one of several strategies for management of bacterial infections in patients undergoing Hematopoietic Stem Cell Transplant (HSCT) (empiric strategy).	23029441
PDX1 gene	Stem Cell Exhaustion	Differentiation of human adipose tissue-derived stem cells into aggregates of insulin-producing cells through the overexpression of pancreatic and duodenal homeobox gene-1.	23031216
Specialty Type - cancer	Stem Cell Exhaustion	Loss of p53 results in increased expression of CD44, a cancer stem cell (CSC) marker, which is involved in the scavenging of reactive oxygen species (ROS).	23031740
Hematologic Neoplasms	Stem Cell Exhaustion	Longitudinal changes in body mass and composition in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem-cell transplantation.	23032628
Hematologic Neoplasms	Stem Cell Exhaustion	To measure longitudinal changes in body mass and composition in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem-cell transplantation (HSCT).	23032628
Malignant Neoplasms	Stem Cell Exhaustion	A quantitative Malignancy Index Diagnostic System (qMIDS) was developed based on 14 FOXM1 (isoform B)-associated genes implicated in the regulation of the cell cycle, differentiation, ageing, genomic stability, epigenetic and stem cell renewal, and two reference genes.	23034676
Myeloid neoplasm, Mycoses	Stem Cell Exhaustion	Granulocyte macrophage colony-stimulating factor in 66 patients with myeloid or lymphoid neoplasms and recipients of hematopoietic stem cell transplantation with invasive fungal disease.	23038157
Prostate carcinoma, Benign prostatic hypertrophy	Stem Cell Exhaustion	We isolated and characterized CD31(-)CD34(+)CD45(-)CD146(-) progenitor cells (adipose-derived stem cells [ASC]) in paired samples of PP and preperitoneal visceral adipose tissue from prostate tissue and peripheral blood mononuclear cells of prostate cancer and nodular prostatic hyperplasia patients.	23038706
Malignant neoplasm of prostate	Stem Cell Exhaustion	Concordantly, adipsin gene (CFD) expression, which is known to be up-regulated in adipose stem cells, was overexpressed in PP adipose tissue, in the prostate of cancer patients and in prostate CD31(-)CD34(+)CD45(-)CD146(-) sorted cells.	23038706
Prostate carcinoma	Stem Cell Exhaustion	While the role of periprostatic (PP) adipose tissue in prostate cancer progression has been barely appreciated, we sought to determine the progenitor cell population in PP adipose tissue and the association with prostate cancer.	23038706
Prostatic Neoplasms	Stem Cell Exhaustion	Human periprostatic white adipose tissue is rich in stromal progenitor cells and a potential source of prostate tumor stroma.	23038706
Neoplasms	Stem Cell Exhaustion	A body of growing evidence now implicates white adipose tissue as a relevant source of stromal progenitor cells recruited to the tumor microenvironment to form supportive tumor stroma.	23038706
Prostatic Neoplasms	Stem Cell Exhaustion	Present findings indicate that PP adipose tissue is a reservoir of progenitor cells with the potential to migrate towards prostate tumors, although its clinical significance merits further evaluation.	23038706
Multiple Myeloma	Stem Cell Exhaustion	[Effect of bortezomib on the efficiency of hematopoietic stem cell mobilization in patients with multiple myeloma].	23038970
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	To study the results of mobilizing and collecting autologous hematopoietic stem cells (HSC) in patients with multiple myeloma (MM) receiving bortezomib as part of induction therapy regimens.	23038970
Mycoses	Stem Cell Exhaustion	[Invasive mycoses during hematopoietic stem cell transplantation].	23038972
Mycoses	Stem Cell Exhaustion	To define the frequency, etiology, and risk factors of invasive mycoses (IM) in patients with allogeneic (allo) and autologous (auto) hematopoietic stem cell transplantation (HSCT) and to evaluate the impact of IM on overall survival (OS).	23038972
Sepsis, Neutropenia, Lymphopenia, Infection, Gastrointestinal mucositis, Graft vs Host Reaction, Acute lymphocytic leukemia	Stem Cell Exhaustion	Its risk factors are acute lymphoblastic leukemia; non-myeloablative conditioning regimen; use of fludarabine and antilymphocyte globulin; peripheral blood stem cells as a source for grafting; long-term lymphopenia, neutropenia; use of granulocyte colony-stimulating factor (G-CSF); acute graft-versus-host reaction; grade 3-4 mucositis; infections, such as cytomegalovirus, sepsis.	23038972
palladium	Stem Cell Exhaustion	This study is the first to test stem cell therapy in an animal model of PD.	23040209
Fibrosis Assessment, Peyronie Disease	Stem Cell Exhaustion	Intratunical injection of human adipose tissue-derived stem cells prevents fibrosis and is associated with improved erectile function in a rat model of Peyronie's disease.	23040209
palladium, Elastoid degeneration, Fibrosis Assessment	Stem Cell Exhaustion	To test the effects of a local injection of adipose tissue-derived stem cells (ADSCs) in the active phase of a rat model of PD on the subsequent development of fibrosis and elastosis of the TA and underlying erectile tissue.	23040209
Central neuroblastoma	Stem Cell Exhaustion	We describe a case of a 5-year-old girl with central nervous system relapse of neuroblastoma after high-dose chemotherapy and autologous stem cell transplantation.	23042021
Childhood Breast Carcinoma	Stem Cell Exhaustion	Established breast cancer stem cell markers do not correlate with in vivo tumorigenicity of tumor-initiating cells.	23042145
Decompensated cirrhosis of liver	Stem Cell Exhaustion	[Prospective controlled trial of safety of human umbilical cord derived-mesenchymal stem cell transplantation in patients with decompensated liver cirrhosis].	23044231
Decompensated cirrhosis of liver	Stem Cell Exhaustion	To evaluate the safety of human umbilical cord derived-mesenchymal stem cell (UC-MSC) transplantation therapy in patients with decompensated liver cirrhosis.	23044231
Exanthema, Ulcer, Herpes zoster disease	Stem Cell Exhaustion	Disseminated zoster presenting as gastric ulcers in the absence of the classic rash is unusual but has been reported in immunosuppressed patients with a history of bone marrow and stem cell transplant.	23045567
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	HLA-mismatched stem-cell microtransplantation as postremission therapy for acute myeloid leukemia: long-term follow-up.	23045576
Graft-vs-Host Disease	Stem Cell Exhaustion	Whether HLA-mismatched stem-cell microtransplantation as a novel postremission therapy in these patients will improve survival and avoid graft-versus-host disease (GVHD) is still unknown.	23045576
Graft-vs-Host Disease	Stem Cell Exhaustion	One hundred one patients with AML-CR1 (9 to 65 years old) from four treatment centers received programmed infusions of G-CSF-mobilized HLA-mismatched donor peripheral-blood stem cells after each of three cycles of high-dose cytarabine conditioning without GVHD prophylaxis.	23045576
Multiple Myeloma, Lymphoma, Non-Hodgkin, Chronic leukemia (category), Medicine, Non-Malignant Disease, Acute leukemia	Stem Cell Exhaustion	Participants mean age at hematopoietic stem cell-transplantation was 42 (range 1 to 72) years; there were 69 males and 47 females; 30 patients had multiple myeloma; 41 had non-Hodgkin and Hodgkin's lymphomas; 22 had acute leukemia; 6 had chronic leukemia; and 17 had non-malignant disease.	23045832
Paroxysmal nocturnal hemoglobinuria, Bone marrow hypocellularity, Hemoglobinuria, CTCAE 3.0, Anemia, Hemolytic	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal, hematopoietic stem cell disorder that manifests with hemolytic anemia and bone marrow failure.	23046169
Malignant neoplasm of esophagus	Stem Cell Exhaustion	The oncoprotein and stem cell renewal factor BMI1 associates with poor clinical outcome in oesophageal cancer patients undergoing preoperative chemoradiotherapy.	23046527
Specialty Type - cancer	Stem Cell Exhaustion	The polycomb group (PcG) family BMI1, acting downstream of the hedgehog (Hh) pathway, plays an essential role in the self-renewal of haematopoietic, neural, and intestinal stem cells, and is dysregulated in many types of cancer.	23046527
Specialty Type - cancer	Stem Cell Exhaustion	These findings suggest that BMI1 signal activation might be involved in promoting cancer regrowth and progression after CRT, and might be indicative of emergence of 'more aggressive' cancer progenitor cells.	23046527
Childhood Breast Carcinoma, Secondary Neoplasm	Stem Cell Exhaustion	Relationship of CD44+CD24-/low breast cancer stem cells and axillary lymph node metastasis.	23046710
Childhood Breast Carcinoma	Stem Cell Exhaustion	Breast cancer stem cells, identified on the basis of CD44+CD24-/low expression, are associated with metastases and drug resistance.	23046710
Childhood Breast Carcinoma	Stem Cell Exhaustion	It is therefore important to investigate the proportion of CD44+CD24-/low breast cancer stem cells for the diagnosis of metastases in axillary nodes.	23046710
Childhood Breast Carcinoma	Stem Cell Exhaustion	CD44+CD24-/low breast cancer stem cells might help clinicians to determine the presence of LN metastases.	23046710
Multiple Myeloma, Atrial Fibrillation by ECG Finding	Stem Cell Exhaustion	Atrial fibrillation following autologous stem cell transplantation in patients with multiple myeloma: incidence and risk factors.	23047326
Atrial Fibrillation, Multiple Myeloma, Atrial Fibrillation by ECG Finding	Stem Cell Exhaustion	Atrial fibrillation (AF) often develops in patients with multiple myeloma following autologous stem cell transplantation (ASCT), but the exact incidence of, and the risk factors for AF have not been described.	23047326
Neoplasms	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) may be recruited from bone marrow to sustain tumor vascularisation and promote the metastatic switch.	23049731
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	We hypothesized that a cancer stem cell marker may identify NAC-resistant patients, and evaluated CD133 and ALDH1 as a potential surrogate marker for breast cancer.	23049880
Urinary Stress Incontinence	Stem Cell Exhaustion	We examined the effect of myostatin and myostatin inhibition by an antagonistic agent, follistatin, on growth of human urethral rhabdosphincter satellite cells (muscle stem cells) to develop a new strategy for treatment of stress urinary incontinence.	23050675
Inflammation, Communicable Diseases	Stem Cell Exhaustion	Tb4 likely acts to repair and regenerate wounds by promoting cell migration and stem cell mobilization and differentiation, and by inhibiting inflammation, apoptosis, and infection.	23050815
Lung Injury	Stem Cell Exhaustion	Amelioration of paraquat-induced pulmonary injury by mesenchymal stem cells.	23051186
Cerebral hypomyelination	Stem Cell Exhaustion	Human central nervous system stem cells (HuCNS-SCs) can develop into oligodendrocytes and confer structurally normal myelin when transplanted into a hypomyelinating mouse model.	23052294
Malignant tumor of colon, Neoplasms	Stem Cell Exhaustion	A tumor hypoxic niche protects human colon cancer stem cells from chemotherapy.	23052691
Specialty Type - cancer, Hypoxia	Stem Cell Exhaustion	Hypoxia has been found to play an important role in regulating the biological characteristics of cancer stem cells (cCSCs).	23052691
Venoocclusive disease	Stem Cell Exhaustion	Four patients conducted HDC with stem cell rescue after CIRT and 1 patient suffered from veno-occlusive disease just after HDC.	23053401
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	Cancer stem cell markers are associated with adverse biomarker profiles and molecular subtypes of breast cancer.	23053657
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	Cumulative evidence has demonstrated the presence of cancer stem cells (CSC) in breast cancer and its putative role in cancer progression.	23053657
Lymphoma	Stem Cell Exhaustion	Safety and feasibility of high-dose ranimustine (MCNU), carboplatin, etoposide, and cyclophosphamide (MCVC) therapy followed by autologous stem cell transplantation for malignant lymphoma.	23054649
Lymphoma	Stem Cell Exhaustion	High-dose chemotherapy followed by autologous stem cell transplantation (auto-SCT) is widely used as a salvage therapy in the treatment of refractory malignant lymphoma.	23054649
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The patient was treated with standard AML chemotherapy and autologous peripheral blood stem cell transplantation.	23054652
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	Cancer stem cell-related gene periostin: a novel prognostic marker for breast cancer.	23056395
Childhood Breast Carcinoma	Stem Cell Exhaustion	We investigated the expression status of periostin in breast cancer stem cells and its clinical implications in order to lay a foundation for managing breast cancer.	23056395
Up	Stem Cell Exhaustion	Subsequent comparison of selective epithelial, mesenchymal and cancer stem cell (CSC) markers between AD and NAD populations of CN and CR patients demonstrated an enhanced trend in mRNA expression of E-cadherin, EpCAM, STAT3 and Oct4 in the NAD population of CR patients.	23056490
Up	Stem Cell Exhaustion	AD cells from both CN and CR patients exhibited mesenchymal morphology with an antigen profile of mesenchymal stem cells and fibroblasts.	23056490
Inflammation, Cerebrovascular accident	Stem Cell Exhaustion	Clinical stroke trials with stem cell-based approaches aiming for trophic actions, modulation of inflammation and neuroprotection are ongoing.	23057628
Micropapillary carcinoma, Colorectal Carcinoma, Neoplasms	Stem Cell Exhaustion	We hypothesized that the aggressive features of micropapillary carcinoma might be related to the presence of more tumor cells with stem cell phenotype in colorectal cancer.	23060121
Micropapillary carcinoma, Carcinoma, Papillary	Stem Cell Exhaustion	We compared the clinicopathological characteristics, including survival data and immunohistochemical profiles of stem cell markers (SOX2, NOTCH3, CD44v6, CD166, ALDH1) of micropapillary carcinomas with those of randomly selected 112 conventional adenocarcinomas lacking micropapillary carcinoma components (non-micropapillary carcinoma) in the colorectum.	23060121
Micropapillary carcinoma, Carcinoma, Papillary, Specialty Type - cancer	Stem Cell Exhaustion	We also found a higher expression rate of cancer stem cell markers in micropapillary carcinomas, suggesting their potential contribution to the survival disadvantage of micropapillary carcinoma.	23060121
Colorectal Micropapillary Adenocarcinoma	Stem Cell Exhaustion	Colorectal micropapillary carcinomas are associated with poor prognosis and enriched in markers of stem cells.	23060121
Kidney Neoplasm	Stem Cell Exhaustion	Evaluation of the KIT/stem cell factor axis in renal tumours.	23060556
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	To investigate the expression of the KIT/stem cell factor (SCF) axis in different renal cell carcinoma subtypes with regard to targeted therapies.	23060556
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	We conclude that the GemOD regimen can be administered safely and effectively in elderly patients with relapsed and refractory PTCL who are ineligible for high dose chemotherapy with stem cell transplant.	23061678
Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Iodine-131 rituximab radioimmunotherapy with BEAM conditioning and autologous stem cell transplant salvage therapy for relapsed/refractory aggressive non-Hodgkin lymphoma.	23062193
Lymphoma, Non-Hodgkin, Familial, Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	A standard salvage therapy of relapsed/refractory aggressive non-Hodgkin lymphoma (NHL) comprises autologous stem cell transplantation (ASCT) after chemotherapy conditioning with carmustine, etoposide, cytarabine, and melphalan (BEAM) regimen.	23062193
Aortic valve calcification	Stem Cell Exhaustion	Role of circulating osteogenic progenitor cells in calcific aortic stenosis.	23062532
Aortic valve calcification	Stem Cell Exhaustion	The purpose of this study was to determine the role of circulating endothelial progenitor cells with osteoblastic phenotype (EPC-OCN) in human aortic valve calcification (AVC).	23062532
physiopathological, Wounds and Injuries	Stem Cell Exhaustion	Bone marrow dysfunction is common in severely injured trauma patients, with release of hematopoietic progenitor cells (HPC) into the peripheral blood.	23063381
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Complete remission following chemotherapy with low-dose cytosine arabinoside and macrophage colony-stimulating factor/granulocyte colony-stimulating factor in a patient with relapsed acute myeloid leukemia after stem cell transplantation.	23064572
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The prognosis of patients who relapse with acute myeloid leukemia (AML) after undergoing stem cell transplantation (SCT) is poor.	23064572
Pneumonia, Viral, Toxoplasmosis, Acute lymphocytic leukemia	Stem Cell Exhaustion	Severe pulmonary toxoplasmosis mimicking viral pneumonitis after a third allogeneic stem cell transplantation in a man with acute lymphoblastic leukemia.	23064573
Acute lymphocytic leukemia	Stem Cell Exhaustion	A 22-year-old man with acute lymphoblastic leukemia underwent allogeneic stem cell transplantation (allo-SCT) twice, then underwent allo-SCT a third time due to relapse.	23064573
Specialty Type - cancer	Stem Cell Exhaustion	Thus, the mechanisms of cell division of ACD or symmetric cell division and centrosome inheritance are recapitulated in human cancer cells, and these findings may facilitate studies on cancer stem cells.	23064640
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Extramedullary relapse of acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation: incidence, risk factors and outcomes.	23065502
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Extramedullary relapse after allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia is a contributor to post-transplant mortality but risk factors for, and outcomes of, this condition are not well characterized.	23065502
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We analyzed 257 consecutive patients undergoing allogeneic stem cell transplantation for acute myeloid leukemia at our institution to characterize extramedullary relapse, identify predictive variables and assess outcomes.	23065502
Hematologic Neoplasms	Stem Cell Exhaustion	We examined donor lymphocyte subset counts in relation to post-transplant lymphocyte recovery and transplant events in 220 consecutive myeloablative, T-cell-depleted, HLA-identical sibling hematopoietic stem cell transplant recipients with hematologic malignancies.	23065508
Chronic graft-versus-host disease	Stem Cell Exhaustion	In conclusion, these results identify donor immune characteristics that are associated with lymphocyte recovery, extensive chronic graft-versus-host disease, and survival in the recipient following allogeneic hematopoietic stem cell transplantation.	23065508
Mitochondrial Inheritance	Stem Cell Exhaustion	Overexpression of Bmi1 in granule cell progenitors (GCPs) led to a decrease in cerebellar size due to decreased GCP proliferation and repression of the expression of cyclin genes, whereas Bmi1 overexpression in postmitotic granule cells improved cell survival in response to stress by altering the expression of genes in the mitochondrial cell death pathway and of Myc and Lef-1.	23065639
Coma, Post-Head Injury	Stem Cell Exhaustion	Treatment of severe post-traumatic bone defects with autologous stem cells loaded on allogeneic scaffolds.	23065806
Hematological Disease	Stem Cell Exhaustion	PML primarily occurred not only in HIV-positive patients (33.3%) but also in patients with hematologic disorders after receiving stem cell transplantation, chemotherapy, and/or immunosuppressive treatment (39.6%).	23066763
Central neuroblastoma	Stem Cell Exhaustion	I-131-Metaiodobenzylguanidine therapy with allogeneic cord blood stem cell transplantation for recurrent neuroblastoma.	23067429
Central neuroblastoma	Stem Cell Exhaustion	Iodine-131-metaiodiobenzylguanidine (131I-MIBG) therapy combined with allogeneic cord blood stem cell transplantation (SCT) was used to treat a 4-year-old girl with recurrent neuroblastoma.	23067429
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Poor glycaemic control in type 2 diabetes patients reduces endothelial progenitor cell number by influencing SIRT1 signalling via platelet-activating factor receptor activation.	23070058
Pancreatic Ductal Adenocarcinoma	Stem Cell Exhaustion	Expression of the stem cell markers CD133 and nestin in pancreatic ductal adenocarcinoma and clinical relevance.	23071857
Pancreatic Ductal Adenocarcinoma, Specialty Type - cancer, ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Stem Cell Exhaustion	To evaluate the prognostic implication of cancer stem cell markers in pancreac ductal adenocarcinoma (PDAC), the expression of CD133 and nestin were investigated in a series of PDAC patients in relation to the survival rate.	23071857
Malignant Neoplasms	Stem Cell Exhaustion	CD133 expression is upregulated in PDAC that is related to poor prognosis, and treatment targeted the CD133 positive cancer/cancer stem cells might be a promising therapeutic strategy for this patients.	23071857
Morular Metaplasia of the Endometrium, Malignant Neoplasms, Multiple Myeloma	Stem Cell Exhaustion	Recent studies demonstrate an increased risk of second primary malignancies (SPMs) in patients with multiple myeloma (MM) receiving maintenance lenalidomide after autologous stem cell transplantation (ASCT).	23073267
Parkinson Disease	Stem Cell Exhaustion	Here we report on the generation of induced pluripotent stem cells (iPSCs) derived from Parkinson's disease patients and the implications of LRRK2(G2019S) mutation in human neural-stem-cell (NSC) populations.	23075850
Parkinson Disease	Stem Cell Exhaustion	Disease phenotypes were rescued by targeted correction of the LRRK2(G2019S) mutation with its wild-type counterpart in Parkinson's disease iPSCs and were recapitulated after targeted knock-in of the LRRK2(G2019S) mutation in human embryonic stem cells.	23075850
Keratinized squamous cell of esophagus	Stem Cell Exhaustion	By IHC, Bmi-1 was focally expressed in the basal layers of almost all esophageal squamous mucosa, which was similar to previous reports in other organs related to stem cells.	23078618
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Outcome of relapse after allogeneic stem cell transplant in patients with acute myeloid leukemia.	23082952
Failure, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Although allogeneic stem cell transplant (Allo-SCT) is an effective treatment for high-risk acute myeloid leukemia (AML), relapses remain a major cause of treatment failure.	23082952
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Our results suggest that for non-transplant patients, the tumor burden before treatment, perhaps reflecting cancer stem cell progeny/output, is an indirect measure that may indicate the number of MM cancer stem cells and hence event free survival.	23083101
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation for multiple myeloma: identification of prognostic factors.	23085487
Heart failure, Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Percutaneous, transendocardial injection of bone marrow-derived mononuclear cells in heart failure patients following acute ST-elevation myocardial infarction: ALSTER-Stem Cell trial.	23086792
Infection	Stem Cell Exhaustion	Umbilical cord blood (UCB) stem cells are frequently employed for allogeneic stem cell transplant, but delayed myeloid and lymphoid immune reconstitution leads to increased risk of infections.	23088744
Kidney Neoplasm, Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	The mean circulating endothelial progenitor cell level in patients with renal cell carcinoma was 0.281%, significantly higher than in patients with benign renal tumors and healthy controls (0.073% and 0.076%, respectively, each p <0.001).	23088990
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	The preoperative circulating endothelial progenitor cell level positively correlated with serum vascular endothelial growth factor in patients with renal cell carcinoma (r = 0.710, p <0.001).	23088990
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	A high circulating endothelial progenitor cell level was found in patients with renal cell carcinoma, which positively correlated with serum vascular endothelial growth factor.	23088990
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	High level of circulating endothelial progenitor cells positively correlates with serum vascular endothelial growth factor in patients with renal cell carcinoma.	23088990
Neoplasms, Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Although accumulated evidence indicates that circulating endothelial progenitor cells contribute to tumor neovascularization, to our knowledge the level of these cells and its correlation with serum vascular endothelial growth factor in patients with renal cell carcinoma have not been studied.	23088990
Kidney Neoplasm, Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	The level of circulating endothelial progenitor cells (percent of total peripheral blood mononuclear cells) was quantified by assaying the CD45(-)CD34(+)vascular endothelial growth factor receptor 2(+) cell phenotype in 53 patients with renal cell carcinoma, 33 with benign renal tumors and 40 healthy controls.	23088990
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Results support the potential use of circulating endothelial progenitor cells as a novel biomarker for renal cell carcinoma.	23088990
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Rituximab, fludarabine, and total body irradiation as conditioning regimen before allogeneic hematopoietic stem cell transplantation for advanced chronic lymphocytic leukemia: long-term prospective multicenter study.	23089183
Toxic effect, Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	To evaluate the efficacy and toxicity of reduced-intensity conditioning (RIC) combining fludarabine, low-dose total body irradiation (TBI) and rituximab before allogeneic hematopoietic stem cell transplantation (allo-HSCT) from human leucocyte antigen (HLA) identical siblings, we conducted a prospective study in patients <=65 years old with advanced chronic lymphocytic leukemia (CLL) stage B or C in response after a salvage treatment.	23089183
Neutropenia, Acute GVH disease	Stem Cell Exhaustion	Many days at home during neutropenia after allogeneic hematopoietic stem cell transplantation correlates with low incidence of acute graft-versus-host disease.	23089563
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Single-molecule genomic data delineate patient-specific tumor profiles and cancer stem cell organization.	23090114
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Substantial evidence supports the concept that cancers are organized in a cellular hierarchy with cancer stem cells (CSC) at the apex.	23090114
Aggressive Non-Hodgkin Lymphoma, B-Cell Lymphomas	Stem Cell Exhaustion	Rituximab maintenance therapy after autologous stem-cell transplantation in patients with relapsed CD20(+) diffuse large B-cell lymphoma: final analysis of the collaborative trial in relapsed aggressive lymphoma.	23091101
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	The standard treatment for relapsed diffuse large B-cell lymphoma (DLBCL) is salvage chemotherapy followed by high-dose therapy and autologous stem-cell transplantation (ASCT).	23091101
Specialty Type - cancer	Stem Cell Exhaustion	LGR5 and Nanog were recently characterized as stem cell markers in various embryonic, adult and cancer stem cells.	23092806
Viremia	Stem Cell Exhaustion	Adenovirus viremia and disease: comparison of T cell-depleted and conventional hematopoietic stem cell transplantation recipients from a single institution.	23092814
PAFAH1B1 wt Allele	Stem Cell Exhaustion	This investigation is the first attempt to correlate the gene expression profile of AURKA and AURKB in a cytogenetically stratified population of mesenchymal stem cells (MSCs) from MDS patients.	23092930
Specialty Type - cancer, Ovarian Serous Adenocarcinoma	Stem Cell Exhaustion	Prognostic impact of the cancer stem cell-related marker NANOG in ovarian serous carcinoma.	23095773
Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH), a clonal hematopoietic stem cell disorder, manifests when the PNH clone populates in the hematopoietic compartment.	23095789
Malignant neoplasm of liver	Stem Cell Exhaustion	The stem cell E3-ligase Lin-41 promotes liver cancer progression through inhibition of microRNA-mediated gene silencing.	23097274
Neoplasms	Stem Cell Exhaustion	Lin-41 is a stem cell-specific E3 ligase and a known target of the tumour suppressor microRNA (miRNA) let-7.	23097274
Hindfoot (body structure)	Stem Cell Exhaustion	The present study reviewed the use of stem cell grafting in hindfoot and ankle surgery and the healing times in high-risk patients.	23102874
Neutropenia, Fever, Mycoses	Stem Cell Exhaustion	Our study highlights the potential success of a set of prevention measures mainly designed to reduce invasive environmental fungal infections in allogeneic hematopoietic stem cell transplant patients, in reducing fever and mortality among neutropenic cancer patients.	23102987
Osteoporosis	Stem Cell Exhaustion	The omega-6 arachidonic fatty acid, but not the omega-3 fatty acids, inhibits osteoblastogenesis and induces adipogenesis of human mesenchymal stem cells: potential implication in osteoporosis.	23104199
diabetic	Stem Cell Exhaustion	Recently, animal studies have demonstrated the efficacy of endothelial progenitor cell (EPC) therapy for diabetic wound healing.	23107450
Diabetes Mellitus	Stem Cell Exhaustion	Stem cell-based therapies have recently opened up new horizons for treatment of various types of diseases including diabetes mellitus.	23109026
diabetic	Stem Cell Exhaustion	Hereby, we aim to report the one-year follow-up results in the diabetic patients who underwent fetal liver-derived hematopoietic stem cell allotransplantation.	23109026
Hair follicle structure	Stem Cell Exhaustion	These observations are consistent with the role of the hair follicle as a major reservoir for progenitor cells.	23110506
Aggressive course, Carcinogenesis	Stem Cell Exhaustion	Furthermore, according to the stem-cell theory of carcinogenesis, aggressive tumors are characterized by an increase number of malignant stem-like cell population and their resistance to chemotherapy has been found to be mitochondrially driven.	23111201
Specialty Type - cancer, Carcinogenesis	Stem Cell Exhaustion	In case the hypothesis of stem-cell bioenergetic malformations' related carcinogenesis proves to be correct, it would contribute to the development of new prognostic, diagnostic and even more effective therapeutic interventions against various types of cancer.	23111201
Carcinogenesis	Stem Cell Exhaustion	Mitochondria malfunctions as mediators of stem-cells' related carcinogenesis: a hypothesis that supports the highly conserved profile of carcinogenesis.	23111201
Transcription Initiation	Stem Cell Exhaustion	Specifically, we support that mitochondrial and/or nuclear DNA alterations that control stem cells' ATP production drive stem cells to "immortalization" (Otto Warburg theory) that mediates cancer initiation and progression.	23111201
Hematologic Neoplasms, Mycoses	Stem Cell Exhaustion	Invasive fungal infection (IFI) causes morbidity and mortality among patients with hematological malignancies who receive cytotoxic chemotherapy or hematopoietic stem cell transplantation (HSCT).	23111539
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Response to pretransplant hypomethylating agents influences the outcome of allogeneic hematopoietic stem cell transplantation in adults with myelodysplastic syndromes.	23113470
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	[Expression of c-MPL in leukemic stem cells from acute myeloid leukemia patients].	23114117
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This study was aimed to investigate the expression of c-MPL in acute myeloid leukemia (AML) and the correlation of the c-MPL expression with CD34 and CD38, so as to define the expression of c-MPL in leukemic stem cells.	23114117
Primary Myelofibrosis, Splenomegaly	Stem Cell Exhaustion	Splenic irradiation as a component of a reduced-intensity conditioning regimen for hematopoietic stem cell transplantation in myelofibrosis with massive splenomegaly.	23117264
Primary Myelofibrosis, Splenomegaly	Stem Cell Exhaustion	Although allogeneic hematopoietic stem cell transplantation (HSCT) is currently the only curative strategy for both conditions, massive splenomegaly frequently observed in patients with myelofibrosis is considered to be a risk factor for graft failure or engraftment delay after transplantation.	23117264
Myelofibrosis Transformation in Essential Thrombocythemia, Primary Myelofibrosis	Stem Cell Exhaustion	The first patient was a 60-year-old woman who received peripheral blood stem cell transplantation for post-essential thrombocythemia myelofibrosis from an HLA-identical sibling; the second patient was a 60-year-old man who received unrelated bone marrow transplantation for primary myelofibrosis.	23117264
Ischemic cardiomyopathy	Stem Cell Exhaustion	Comparison of allogeneic vs autologous bone marrow-derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial.	23117550
Ischemic cardiomyopathy, between breakfast and lunch	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) are under evaluation as a therapy for ischemic cardiomyopathy (ICM).	23117550
Multiple Myeloma	Stem Cell Exhaustion	There are no uniform guidelines for the treatment of relapsed refractory multiple myeloma (MM), however autologous stem cell transplant (SCT) remains an important treatment modality.	23121086
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The use of interferon-a and allogeneic stem cell transplant and more recently of tyrosine kinase inhibitors (TKIs) have improved the outcome of patients with chronic myeloid leukemia (CML).	23121646
Hepatic Encephalopathy, Acute lymphocytic leukemia	Stem Cell Exhaustion	Posterior reversible encephalopathy syndrome was most often observed during acute lymphoblastic leukemia induction chemotherapy (n = 9, 47.4%) and after hematopoietic stem cell transplantation (n = 8, 42.1%).	23127265
Encephalopathy, CTCAE 5.0, Hypertension, CTCAE	Stem Cell Exhaustion	Among eight patients with the complication of posterior reversible encephalopathy syndrome after hematopoietic stem cell transplantation, five (62.5%) had a history of hypertension.	23127265
Hepatic Encephalopathy, Hypertension, CTCAE	Stem Cell Exhaustion	In contrast, among 11 patients with the complication of posterior reversible encephalopathy syndrome without hematopoietic stem cell transplantation, only one (9.1%) had a history of hypertension.	23127265
Acute lymphocytic leukemia, Hepatic Encephalopathy, Hypertension, CTCAE	Stem Cell Exhaustion	Acute lymphoblastic leukemia chemotherapy regimens apparently comprised the main predisposing factors for posterior reversible encephalopathy syndrome complicated during induction chemotherapy, compared with hypertension and immunosuppressive agents after hematopoietic stem cell transplantation.	23127265
Fibrosis Assessment	Stem Cell Exhaustion	Confocal imaging of the limbus revealed normal palisades of Vogt structure and epithelial transition in the healthy eyes while demonstrating a variable degree of alterations, including loss of the limbal palisades and of the normal epithelial mosaic, cystic epithelial changes, and subepithelial fibrosis, in the eyes affected by partial or total limbal stem cell deficiency.	23127748
Hodgkin Disease	Stem Cell Exhaustion	Autologous stem cell transplantation for refractory or poor-risk relapsed Hodgkin's lymphoma: effect of the specific high-dose chemotherapy regimen on outcome.	23128322
Neoplasms	Stem Cell Exhaustion	Id4 plays an important role in neuronal stem cell differentiation, and its deregulation has been implicated in glial neoplasia.	23132729
Depression, CTCAE, Anxiety Disorders	Stem Cell Exhaustion	Predictors of anxiety and depression in hematopoietic stem cell transplant patients during protective isolation.	23132747
Depression, CTCAE, Anxiety Disorders	Stem Cell Exhaustion	To examine in a sample of hematopoietic stem cell transplant patients assessed throughout protective isolation (i) levels of anxiety and depression and (ii) pre-isolation factors (socio-demographics, biomedical variables and personality traits), which might predict higher levels of anxiety and depression during isolation.	23132747
Depression, CTCAE, Anxiety Disorders	Stem Cell Exhaustion	Anxiety and depression represent a relevant problem for hematopoietic stem cell transplant patients during isolation.	23132747
Liver carcinoma	Stem Cell Exhaustion	High mobility group AT-hook 2 was also expressed in a subset of hepatocellular carcinomas in association with b-catenin expression; this might represent a subtype of hepatocellular carcinoma with hepatic progenitor cell differentiation.	23134771
Liver neoplasms	Stem Cell Exhaustion	Expression of high mobility group AT-hook 2, an architectural nuclear factor and marker for hepatic progenitor cells, has not been studied in detail in hepatocellular neoplasms.	23134771
Intrahepatic bile duct, Bile Ducts, Extrahepatic	Stem Cell Exhaustion	Embryologically, intrahepatic small bile ducts arise from hepatic progenitor cells via ductal plates, whereas the pancreato-extrahepatic biliary progenitor cells expressing the transcription factors PDX1 and HES1 are reportedly involved in the development of the extrahepatic biliary tract and ventral pancreas.	23134772
Aplastic Anemia	Stem Cell Exhaustion	[Outcome of allogeneic hematopoietic stem cell transplantation from HLA-matched sibling donor for 41 cases of severe aplastic anemia].	23134851
Aplastic Anemia	Stem Cell Exhaustion	To evaluate the outcome of allogeneic hematopoietic stem cell transplantation (allo-HSCT) from HLA-matched sibling donor (MSD allo-HSCT) for severe aplastic anemia (SAA).	23134851
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	3/80 patients with AML got stem cell mobilization failure.	23134856
Failure	Stem Cell Exhaustion	5 of 6 patients who failed to mobilize before got successful stem cell mobilization, 1/6 patient with AML-M(5) got a second failure after the mobilization of VP16 whose first time's mobilization using Ara-C did not succeed.	23134856
Hematologic Neoplasms	Stem Cell Exhaustion	[Clinical study on high-dose etoposide with granulocyte colony-stimulating factor for mobilization of autologous peripheral blood stem cells in patients with hematologic malignancies].	23134856
Hematologic Neoplasms	Stem Cell Exhaustion	To explore the effectivity and safety of single high-dose (HD) etoposide (Vp16) with granulocyte colony-stimulating factor (G-CSF) for mobilization of autologous peripheral blood stem cells (PBSC) in patients with hematologic malignancies.	23134856
Antilymphocyte Serum	Stem Cell Exhaustion	Autologous bone marrow-derived stem cell therapy is safe and feasible in patients of ALS.	23135021
Amyotrophic Lateral Sclerosis	Stem Cell Exhaustion	Autologous bone marrow-derived stem cells in amyotrophic lateral sclerosis: a pilot study.	23135021
Antilymphocyte Serum	Stem Cell Exhaustion	To assess the feasibility, efficacy and safety of autologous bone marrow-derived stem cells in patients of ALS.	23135021
Antilymphocyte Serum	Stem Cell Exhaustion	We conducted an open-label pilot study of autologous bone marrow-derived stem cells in patients with ALS attending the Neurology Clinic of a tertiary care referral centre.	23135021
Antilymphocyte Serum	Stem Cell Exhaustion	Ten patients with ALS with mean revised ALS Functional Rating Scale (ALSFRS-R) score of 30.2 (+- 10.58) at baseline received intrathecal autologous bone marrow-derived stem cells.	23135021
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Prognostic significance of 11q23 aberrations in adult acute myeloid leukemia and the role of allogeneic stem cell transplantation.	23135353
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Using intention-to treat analysis based on donor availability, we also noted that allogeneic stem cell transplant in first remission had a significant benefit toward improving OS (P<0.001) and relapse-free survival (P<0.001) in patients with AML and 11q23 abnormalities.	23135353
Multiple Myeloma	Stem Cell Exhaustion	We conducted a phase II trial that evaluated the tolerability and efficacy of combining lenalidomide with melphalan in previously untreated patients with multiple myeloma who were not candidates for autologous stem cell transplantation.	23141150
Multiple Myeloma	Stem Cell Exhaustion	Interferon (INF)-a was the maintenance treatment of choice after autologous stem cell transplantation in multiple myeloma in the past, but currently Thalidomide is commonly used.	23142220
Multiple Myeloma	Stem Cell Exhaustion	Bortezomib plus dexamethasone followed by escalating donor lymphocyte infusions for patients with multiple myeloma relapsing or progressing after allogeneic stem cell transplantation.	23142330
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Isolation of glioma cancer stem cells in relation to histological grades in glioma specimens.	23143002
Adult Glioblastoma, Specialty Type - cancer	Stem Cell Exhaustion	The existence of cancer stem cells (CSCs) in glioblastoma has been proposed.	23143002
Communicable Diseases, Lymphoproliferative Disorders, Opportunistic Infections, Kidney Failure, Acute, Specialty Type - cancer, Acute leukemia	Stem Cell Exhaustion	Opportunistic infections were associated with steroids, lymphoproliferative disorders and haematopoietic stem-cell transplantation, whereas noninfectious disorders were associated with acute leukaemia The selected criteria are strongly associated with causes of ARF in cancer patients and could be used to develop an algorithm for selecting first-line diagnostic investigations and empirical treatments.	23143549
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Diffuse large B-cell lymphoma is an aggressive non-Hodgkin's lymphoma without a standard therapy for patients who relapse after or are not eligible for salvage autologous stem cell transplantation.	23144193
Central Nervous System, Lymphoma	Stem Cell Exhaustion	Central nervous system recurrence of systemic lymphoma in the era of stem cell transplantation--an International Primary Central Nervous System Lymphoma Study Group project.	23144196
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Autologous stem cell transplantation has greatly improved the prognosis of systemic recurrent non-Hodgkin's lymphoma.	23144196
Lymphoma	Stem Cell Exhaustion	We, therefore, we performed an international multicenter retrospective study of patients with a central nervous system recurrence of systemic lymphoma to assess the outcome of these patients in the era of stem cell transplantation.	23144196
Lymphoma	Stem Cell Exhaustion	In conclusion, despite the availability of autologous stem cell transplantation for patients with central nervous system progression or relapse of systemic lymphoma, prognosis is still poor.	23144196
Lymphoma, Follicular	Stem Cell Exhaustion	Defining the role of high-dose therapy with autologous stem cell rescue in the therapeutic algorithm of follicular lymphoma remains a major challenge.	23144201
Lymphoma, Follicular	Stem Cell Exhaustion	From 1997 to 2008 80 patients (41 males, 39 females; median age, 51 years; range, 31-67) received high-dose therapy with autologous stem cell rescue with BEAM for relapsed follicular lymphoma at our center.	23144201
Lymphoma, Follicular	Stem Cell Exhaustion	In conclusion, high-dose therapy with autologous stem cell rescue with BEAM appears to be equally effective in second or third remission of follicular lymphoma.	23144201
Bisphosphonate-Associated Osteonecrosis of the Jaw, Multiple Myeloma	Stem Cell Exhaustion	Incidence and risk factors of bisphosphonate-related osteonecrosis of the jaw in multiple myeloma patients having undergone autologous stem cell transplantation.	23147542
Multiple Myeloma	Stem Cell Exhaustion	The purpose of the present study was to evaluate the incidence and risk factors for BRONJ in multiple myeloma patients after high-dose chemotherapy and autologous stem cell transplantation (ASCT).	23147542
Respiratory Syncytial Virus Infections, Respiratory Tract Infections	Stem Cell Exhaustion	However, it did not prevent lower respiratory tract infections and did not affect the survival rate of allogeneic stem cell transplant recipients who had RSV infection.	23147965
Myelitis	Stem Cell Exhaustion	The case report that is the subject of this Commentary describes a 27-year-old woman, who, 3 months after a devastating low cervical myelitis, underwent intrathecal mesenchymal stem cell (MSC) infusions.	23149272
Multiple Myeloma	Stem Cell Exhaustion	We analysed the long-term outcomes of 60 multiple myeloma patients who underwent reduced intensity allogeneic stem cell transplantation between August 2000 and March 2008.	23151215
Prediabetes syndrome	Stem Cell Exhaustion	Impact of ADMA, endothelial progenitor cells and traditional cardiovascular risk factors on pulse wave velocity among prediabetic individuals.	23153108
Arterial Stiffness	Stem Cell Exhaustion	Decreased circulating endothelial progenitor cells (EPCs), increased asymmetric dimethyl-arginine (ADMA) levels, traditional cardiovascular risk factors and insulin resistance have all been associated with increased arterial stiffness.	23153108
Colorectal Carcinoma	Stem Cell Exhaustion	Lgr5 is a potential marker of colorectal carcinoma stem cells that correlates with patient survival.	23153436
Colorectal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	In order to determine whether Lgr5 is a potential marker of cancer stem cells, we investigated whether Lgr5 expression correlated with Ki-67 expression and prognosis in colorectal carcinoma.	23153436
Colorectal Carcinoma	Stem Cell Exhaustion	It may also be considered as a potential marker for colorectal cancer stem cells (CSCs).	23153436
Encephalitis, Optic Neuritis, Encephalomyelitis, Acute Disseminated	Stem Cell Exhaustion	We report a 27-year-old woman with an episode of encephalitis and optic neuritis, followed by autologous bone marrow mesenchymal stem cell transplants and possible induction of acute disseminated encephalomyelitis-like demyelinating illness.	23157845
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Hyper-CVAD chemotherapy or autologous stem cell transplantation in patients with peripheral T cell lymphomas: a single centre report.	23158157
Multiple Myeloma	Stem Cell Exhaustion	WT1-specific T-cell responses in high-risk multiple myeloma patients undergoing allogeneic T cell-depleted hematopoietic stem cell transplantation and donor lymphocyte infusions.	23160468
Myeloid Leukemia, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	While the emergence of WT1-specific cytotoxic T lymphocytes (WT1-CTL) has been correlated with better relapse-free survival after allogeneic stem cell transplantation in patients with myeloid leukemias, little is known about the role of these cells in multiple myeloma (MM).	23160468
Malignant Neoplasms	Stem Cell Exhaustion	As tissue stem cells exist in many adult tissues other than the CNS, Musashi is considered to be associated with many malignancies.	23164718
Hematologic Neoplasms	Stem Cell Exhaustion	Haploidentical hematopoietic stem cell transplantation for hematologic malignancies.	23165479
Lymphoma	Stem Cell Exhaustion	The effectiveness of stem cell mobilization with G-CSF in lymphoma patients is suboptimal.	23165501
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Here, we examined the efficacy and safety of a dose-intensified CHOP regimen (Double-CHOP), which was followed by autologous stem-cell transplantation (ASCT) or high-dose methotrexate (HDMTX), in PTCL patients.	23166041
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	The management of patients with Hodgkin lymphoma (HL) recurring after stem cell transplantation (SCT) and multiply relapsed disease remains challenging.	23167437
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	High-dose therapy (HDT) followed by transplantation of autologous haemopoietic stem cells is frequently done as part of first-line therapy in young patients with high-risk aggressive B-cell lymphoma.	23168367
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Data from 44 MDS subjects receiving subcutaneous romiplostim (dose range 300-1500 mg week(-1) ) were used to develop a pharmacodynamic model consisting of a romiplostim-sensitive progenitor cell compartment linked to the peripheral blood compartment through four transit compartments representing the maturation in the bone marrow from megakaryocytes to platelets.	23171070
Malignant neoplasm of ovary	Stem Cell Exhaustion	High frequency of putative ovarian cancer stem cells with CD44/CK19 coexpression is associated with decreased progression-free intervals in patients with recurrent epithelial ovarian cancer.	23171677
Malignant neoplasm of ovary	Stem Cell Exhaustion	Epithelial ovarian cancer (EOC) cells with CD44 and CK19 coexpression may represent a subset of ovarian cancer stem cells (OCSCs).	23171677
Injury of kidney	Stem Cell Exhaustion	Acute kidney injury requiring dialysis following carmustine and etoposide during autologous stem cell transplantation.	23171711
Kidney Failure, Acute, Toxic nephropathy	Stem Cell Exhaustion	While acute renal failure requiring renal replacement therapy is a known but rare complication of autologous stem cell transplantation, acute nephrotoxicity following carmustine and etoposide has not yet been reported.	23171711
Kidney Failure, Acute	Stem Cell Exhaustion	We present the first case of carmustine-induced acute kidney injury in the setting of autologous stem cell transplantation and perform a review of the literature.	23171711
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	A placebo-controlled, randomized trial of mesenchymal stem cells in COPD.	23172272
Inflammation	Stem Cell Exhaustion	As disease pathogenesis includes both chronic pulmonary and systemic inflammation, antiinflammatory effects of systemically administered mesenchymal stem cells (MSCs) may decrease inflammation, resulting in improved lung function and quality of life.	23172272
Hyponatremia	Stem Cell Exhaustion	Severe hyponatremia is a critical electrolyte abnormality in allogeneic stem cell transplantation (allo-SCT) recipients and >50% of cases of severe hyponatremia are caused by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH).	23173742
Hyperkeratosis, VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)	Stem Cell Exhaustion	Dermabrasion can repigment vitiligo through stimulation of melanocyte stem cells and elimination of hyperkeratosis.	23174056
Colorectal Carcinoma	Stem Cell Exhaustion	The CD133 antigen has been identified as a putative stem cell marker in colorectal cancer tissues.	23174722
Gastrointestinal Stromal Tumors, Mesenchymal Cell Neoplasm	Stem Cell Exhaustion	Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors originating from interstitial cells of Cajal or related stem cell-like precursors present in the wall of the gastrointestinal tract.	23174729
Liver carcinoma, Hollings Cancer Center, Specialty Type - cancer	Stem Cell Exhaustion	Recent evidence suggests that hepatocellular carcinoma (HCC) is organized by a subset of cells with stem cell features (cancer stem cells; CSCs).	23174907
Specialty Type - cancer	Stem Cell Exhaustion	CSCs are considered a pivotal target for the eradication of cancer, and liver CSCs have been identified by the use of various stem cell markers.	23174907
Liver carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Discrete nature of EpCAM+ and CD90+ cancer stem cells in human hepatocellular carcinoma.	23174907
Thymic Lymphoepithelioma-Like Carcinoma	Stem Cell Exhaustion	Intrathyroidal epithelial thymoma/carcinoma showing thymus-like differentiation; comparison with thymic lymphoepithelioma-like carcinoma and a possibility of development from a multipotential stem cell.	23176314
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In spite of recent advances in molecular diagnostic techniques and expanded indications for allogeneic hematopoietic stem cell transplantation, treatment of acute myeloid leukemia (AML) remains a major challenge.	23176617
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Many patients with multiple myeloma (MM) are elderly (aged >65 years) or unfit, and therefore ineligible for stem-cell transplantation.	23176720
Glioblastoma Multiforme Pathway, Neoplasms	Stem Cell Exhaustion	Here, we examined the expression profile of TRIM11, along with two stem cell markers CD133 and nestin, in multiple glioma patient specimens, glioma primary cultures derived from tumors taken at surgery and normal neural stem/progenitor cells (NSCs).	23178488
Lymphoma, Non-Hodgkin, Familial, Hodgkin Disease, Multiple Myeloma	Stem Cell Exhaustion	Plerixafor and G-CSF for autologous stem cell mobilization in patients with NHL, Hodgkin's lymphoma and multiple myeloma: results from the expanded access program.	23178544
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Refractory acute graft-versus-host disease (aGVHD) remains an important cause of mortality after allogeneic stem cell transplantation.	23178634
Malignant tumor of colon	Stem Cell Exhaustion	Properties of monocytes generated from haematopoietic CD34(+) stem cells from bone marrow of colon cancer patients.	23180014
Bone Marrow, Malignant tumor of colon	Stem Cell Exhaustion	This study explored whether monocytes can be obtained from bone marrow haematopoietic CD34(+) stem cells of colon cancer patients, using previously described protocol of expansion and differentiation to monocytes of cord blood-derived CD34(+) haematopoietic progenitors.	23180014
Specialty Type - cancer	Stem Cell Exhaustion	These observations indicate that generation of monocytes from CD34(+) stem cells of cancer patients is feasible.	23180014
Reduced Number, Aortic Aneurysm, Abdominal	Stem Cell Exhaustion	Reduced number and impaired function of circulating endothelial progenitor cells in patients with abdominal aortic aneurysm.	23182004
Coronary Arteriosclerosis	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPCs) are associated with coronary artery disease (CAD) and predict its outcome.	23182004
Cerebrovascular accident	Stem Cell Exhaustion	Stem cell therapy: a clinical trial of stroke.	23183251
Cerebrovascular accident	Stem Cell Exhaustion	Stem cells act as "scaffolds" for neural transplantation and may aid in repair mechanisms in stroke.	23183251
Diabetes	Stem Cell Exhaustion	Stem cell compartmentalization in diabetes and high cardiovascular risk reveals the role of DPP-4 in diabetic stem cell mobilopathy.	23184393
Ischemia, diabetic	Stem Cell Exhaustion	Indeed, DPP-4 deficiency restored ischemia (but not G-CSF)-induced stem cell mobilization and improved vascular recovery in diabetic animals.	23184393
Diabetes	Stem Cell Exhaustion	In conclusion, the analysis of stem cell compartmentalization in humans led us to discover mechanisms of BM unresponsiveness in diabetes determined by tissue-specific DPP-4 dysregulation.	23184393
Diabetes, Ischemia	Stem Cell Exhaustion	Diabetes differentially affected DPP-4 activity in PB and BM and impaired stem/progenitor cell mobilization after ischemia or G-CSF administration.	23184393
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation: an effective salvage therapy in multiple myeloma.	23186983
Allogeneic Hematopoietic Stem Cell Transplantation, Dry Eye Syndromes	Stem Cell Exhaustion	Prevalence of dry eye syndrome after allogeneic hematopoietic stem cell transplantation.	23187163
Special Handling Code - Dry	Stem Cell Exhaustion	To evaluate the prevalence, severity, and effect of dry eye in patients after allogeneic hematopoietic stem cell transplantation (aHSCT) and to correlate the findings to the duration after transplantation.	23187163
Prostate carcinoma, Neoplasms	Stem Cell Exhaustion	Gefitinib inhibits the cross-talk between mesenchymal stem cells and prostate cancer cells leading to tumor cell proliferation and inhibition of docetaxel activity.	23192362
Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Increasing evidence suggests that bone marrow derived mesenchymal stem cells (BM-MSCs) are recruited into the stroma of developing tumors where they contribute to progression by enhancing tumor growth and metastasis, or by inducing anticancer-drug resistance.	23192362
Prostate carcinoma	Stem Cell Exhaustion	Prostate cancer cells secrete ligands of epidermal growth factor receptor (EGFR) and EGFR signaling could play an important role in the cross-talk between mesenchymal stem cells and prostate cancer cells.	23192362
Specialty Type - cancer, Carcinoma	Stem Cell Exhaustion	High expression of cancer stem cell markers in cholangiolocellular carcinoma.	23192764
Specialty Type - cancer	Stem Cell Exhaustion	It is thought to originate from the ductules and/or canals of Hering, where hepatic stem cells (HpSC) are located, but there are few reports on cancer stem cell markers in CLC.	23192764
Specialty Type - cancer	Stem Cell Exhaustion	Thus, we evaluated the significance of cancer stem cell markers, including CD133, CD44, and EpCAM, in CLC.	23192764
Hodgkin Disease, galiximab, Specialty Type - cancer, leukemia	Stem Cell Exhaustion	Cancer and Leukemia Group B (CALGB) 50602 (Alliance) tested single-agent galiximab in a highly refractory group of patients with Hodgkin lymphoma (median 3 prior regimens, 83% failing after prior stem cell transplant) to determine the efficacy.	23194022
Multiple Myeloma	Stem Cell Exhaustion	Early versus delayed autologous stem cell transplant in patients receiving novel therapies for multiple myeloma.	23194056
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplant (ASCT) is an effective treatment for multiple myeloma (MM).	23194056
Bronchiolitis Obliterans	Stem Cell Exhaustion	Airway dilation in bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation.	23195332
Bronchiolitis Obliterans, Pulmonary Complication, Bosnian language	Stem Cell Exhaustion	Bronchiolitis obliterans syndrome (BOS) is a late, non-infectious pulmonary complication following hematopoietic stem cell transplantation (HSCT).	23195332
Diabetes	Stem Cell Exhaustion	Transgene-free disease-specific induced pluripotent stem cells from patients with type 1 and type 2 diabetes.	23197849
Neurologic Deficits	Stem Cell Exhaustion	Targeting p38 mitogen-activated protein kinase signaling restores subventricular zone neural stem cells and corrects neuromotor deficits in Atm knockout mouse.	23197859
Ischemia	Stem Cell Exhaustion	A phase II trial of autologous transplantation of bone marrow stem cells for critical limb ischemia: results of the Naples and Pietra Ligure Evaluation of Stem Cells study.	23197862
Specialty Type - cancer	Stem Cell Exhaustion	The concept of a stem cell subpopulation as understood from normal epithelial tissue or bone marrow function has been extended to our understanding of cancer tissue and is now the target of treatment efforts specifically directed to this subpopulation.	23201460
Adult Glioblastoma, Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	In glioblastoma, as well as in other cancers, increased expression of aldehyde dehydrogenase (ALDH) has been found localized within a minority sub-population of tumor cells which demonstrate stem cell properties.	23201460
Heat shock proteins	Stem Cell Exhaustion	A separate body of research associated increased expression of heat-shock protein-90 (HSP90) with stem cell attributes.	23201460
Adult Glioblastoma	Stem Cell Exhaustion	That two previously identified proteins associated with stem cell attributes tend to be co-expressed in the same individual glioblastoma cells might have clinical utility.	23201460
Adult Glioblastoma	Stem Cell Exhaustion	These should be explored for the potential to retard aspects of glioblastoma stem cells' function subserved by ALDH and HSP90.	23201460
Blastic plasmacytoid dendritic cell neoplasm	Stem Cell Exhaustion	Stem cell transplantation can provide durable disease control in blastic plasmacytoid dendritic cell neoplasm: a retrospective study from the European Group for Blood and Marrow Transplantation.	23203822
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Due to the high-risk profile of his AML, allogeneic stem cell transplantation (SCT) was performed.	23207728
Graft-vs-Host Disease	Stem Cell Exhaustion	To better determine whether the presence of 6 or fewer apoptotic bodies is sufficient for the diagnosis of GVHD, we retrospectively reviewed 78 colon biopsies from 66 patients who received either hematopoietic stem cell (HSCT) or cord blood cell transplantation and whose colon biopsies exhibited apoptotic bodies.	23211294
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Comparison of human adipose-derived stem cells and bone marrow-derived stem cells in a myocardial infarction model.	23211469
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Treatment of myocardial infarction (MI) with bone marrow-derived mesenchymal stem cells and recently also adipose-derived stem cells has shown promising results.	23211469
Osteopenia	Stem Cell Exhaustion	Transplantation of human umbilical cord blood-derived mesenchymal stem cells or their conditioned medium prevents bone loss in ovariectomized nude mice.	23215868
Liver carcinoma	Stem Cell Exhaustion	Impact of stem cell marker expression on recurrence of TACE-treated hepatocellular carcinoma post liver transplantation.	23216644
Liver carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	The existence of a progenitor cell population, sometimes called cancer stem cells (CSCs), has been proposed to be one mechanism accounting for the chemotherapy resistance and recurrence of hepatocellular carcinoma.	23216644
Myocardial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Myocardial dysfunction in patients with type 2 diabetes mellitus: role of endothelial progenitor cells and oxidative stress.	23217199
Cockayne Syndrome	Stem Cell Exhaustion	Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria.	23217256
Progeria	Stem Cell Exhaustion	The link between conserved SIRT1 longevity pathway and progeria suggests a stem cell-based and SIRT1 pathway-dependent therapeutic strategy for progeria.	23217256
Venous Thrombosis, Hemolysis (biological function), Bone marrow hypocellularity, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria is a clonal stem cell disorder typically characterized by hemolysis, bone marrow failure, and venous thrombosis.	23217954
MS gene	Stem Cell Exhaustion	Recently autologous haematopoietic stem cell transplantation (AHSCT) has been introduced for the treatment of severe forms of multiple sclerosis (MS).	23218837
MS gene	Stem Cell Exhaustion	Immunohistochemistry analysis of bone marrow biopsies in multiple sclerosis patients undergoing autologous haematopoietic stem cells transplantation.	23218837
Sarcoma, Myeloid	Stem Cell Exhaustion	While prospective evaluations are needed, chemotherapy with allogenic hematopoietic stem cell transplantation should be considered as the optimal therapy for isolated myeloid sarcoma.	23218987
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The mechanisms by which hematopoietic stem and progenitor cells (HSC and HPC) from myelodysplastic syndromes (MDS) undergo ineffective production of blood cells and disease transformation into acute myeloid leukemia remain to be investigated.	23219618
Specialty Type - cancer, Nasopharyngeal carcinoma	Stem Cell Exhaustion	Aldehyde dehydrogenase 1, a functional marker for identifying cancer stem cells in human nasopharyngeal carcinoma.	23220285
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Aldehyde dehydrogenase 1 (ALDH1) activity has now been employed successfully as a cancer stem cells (CSCs) marker in various tumors.	23220285
Aortic Valve Insufficiency	Stem Cell Exhaustion	Circulating progenitor and apoptotic progenitor cells in patients with aortic regurgitation.	23220773
Neoplasms	Stem Cell Exhaustion	These findings suggested the probable single stem cell origin of the tumor with differentiation to both cell groups rather than a combination of two different tumors.	23221400
Dyskeratosis Congenita, Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Posttransplant lymphoproliferative disorder complicating hematopoietic stem cell transplantation in a patient with dyskeratosis congenita.	23222806
Aplastic Anemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We present a case of a 28-year-old woman with DC who was admitted for hematopoietic stem cell transplantation (HSCT) for aplastic anemia and who developed acute myeloid leukemia with complex genetic karyotype abnormalities including the MLL (11q23) gene, 1q25, and chromosome 8.	23222806
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Azacitidine fails to eradicate leukemic stem/progenitor cell populations in patients with acute myeloid leukemia and myelodysplasia.	23223186
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Experimentally, leukemic stem/progenitor cells (LSC) propagate disease in animal models of AML and it has been postulated that their relative chemo-resistance contributes to disease relapse.	23223186
Chronic graft-versus-host disease	Stem Cell Exhaustion	Differing impacts of pretransplant serum ferritin and C-reactive protein levels on the incidence of chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.	23225486
Tears body substance	Stem Cell Exhaustion	Most cases recovered by using artificial tears, antibiotic ointment and eye wrap, and other patients required corneal limbal stem cell transplantation with conjunctival flap, even keratoplasty.	23225842
Squamous cell carcinoma of esophagus	Stem Cell Exhaustion	A genetic analysis revealed germ-line lineage-derived chimeric cellular populations of the donor and patient on both the esophageal squamous cell carcinoma and non tumorous portions of the patient's esophageal mucosa with a preponderance of the patient's germ-line lineage-derived cells, suggesting that repopulated donor-derived hemopoietic stem cells in the esophageal epithelia only partially contributed to the carcinogenesis of esophageal squamous cell carcinoma several years after bone marrow transplantation.	23225908
Acute myocardial infarction, Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Worse clinical outcomes in acute myocardial infarction patients with type 2 diabetes mellitus: relevance to impaired endothelial progenitor cells mobilization.	23226370
Impaired	Stem Cell Exhaustion	We hypothesized that this may be related to impairment of bone marrow-derived endothelial progenitor cells (EPCs) mobilization.	23226370
Calcinosis	Stem Cell Exhaustion	This knowledge may help in designing better strategies for stem cell differentiation into chondrocyte-like cells, from this source, with Dic being a viable option for treating OA pain, with an eye toward preventing the potential to enhance calcification in the repair of cartilage and degenerated intervertebral discs.	23231452
Hypertrophy, Degenerative polyarthritis	Stem Cell Exhaustion	We have previously shown that mesenchymal stem cells (MSCs) from patients with osteoarthritis (OA) constitutively express type X collagen, a marker of late-stage chondrocyte hypertrophy, osteogenic marker genes, including alkaline phosphatase (ALP), bone sialoprotein (BSP), and osteocalcin (OC), and chondrogenesis marker gene aggrecan (ACAN).	23231452
Degenerative polyarthritis	Stem Cell Exhaustion	The upregulation of COL10A1 in normal MCSs by Acet and Npx may explain why stem cells from patients with OA express COL10A1 constitutively.	23231452
Respiratory Diaphragm	Stem Cell Exhaustion	The animals injected with stem cells underwent laparoscopy so that stem cells from GFP-labelled rabbit olfactory epithelium could be locally injected into the diaphragm muscle.	23231953
Multiple Myeloma	Stem Cell Exhaustion	Efficacy of stem cell mobilization in patients with newly diagnosed multiple myeloma after a CTD (cyclophosphamide, thalidomide, and dexamethasone) regimen.	23233155
Multiple Myeloma	Stem Cell Exhaustion	Have drug combinations supplanted stem cell transplantation in myeloma?	23233601
Retinal Diseases	Stem Cell Exhaustion	[Effects of bone marrow mesenchymal stem cell transplantation on retinal cell apoptosis in premature rats with retinopathy].	23234789
Retinopathy of Prematurity, Infant, Premature, Retinal Diseases	Stem Cell Exhaustion	To explore the effects of marrow mesenchymal stem cell (BMSC) transplantation on retinal cells apoptosis and changes to neurotrophin-3 (NT-3 and ciliary neurotrophic factor (CNTF) in rats with retinopathy of prematurity (ROP).	23234789
Autoimmune Diseases, MS gene, Glomerulonephritis, Lupus Erythematosus	Stem Cell Exhaustion	Previous in vivo studies have shown that mesenchymal stem cell (MSC) transplantation significantly improves the condition of a number of autoimmune diseases including autoimmune cerebrospinal meningitis, multiple sclerosis, glomerulonephritis and systemic lupus erythematosus.	23237239
Rheumatoid Arthritis	Stem Cell Exhaustion	To investigate the immunoregulatory effect of stem cell transplantation, human umbilical cord MSCs were co-cultured with peripheral blood mononuclear cells (PBMCs) from patients with rheumatoid arthritis (RA).	23237239
Rheumatoid Arthritis	Stem Cell Exhaustion	The allogeneic umbilical cord mesenchymal stem cells regulate the function of T helper 17 cells from patients with rheumatoid arthritis in an in vitro co-culture system.	23237239
Respiratory Tract Infections	Stem Cell Exhaustion	hMPV can cause morbidity in hematopoietic stem cell transplant recipients and recent research has demonstrated that it is an important virus in patients admitted to hospital with respiratory infections and suspected of having pandemic 2009 influenza A (H1N1pdm09) virus.	23239530
H1N1, Influenza	Stem Cell Exhaustion	A total of 288 samples were tested: 165 samples were collected from patients with suspected influenza A (H1N1) pdm09 infection during the first pandemic wave in 2009; and 123 samples were collected from patients of a hematopoietic stem cell transplantation program in 2008-2009.	23239530
Influenza due to Influenza A virus subtype H1N1	Stem Cell Exhaustion	hMPV was detected in 14.2% (41/288) of all samples: 17% (28/165) of immunocompetent patients with suspected H1N1 infection and 10.6% (13/123) among hematopoietic stem cell transplant recipients.	23239530
Inflammation, Stem Cell Factor	Stem Cell Exhaustion	RDW, markers of inflammation and stem cell factor (SCF) were determined.	23239558
Specialty Type - cancer	Stem Cell Exhaustion	This positive feedback loop regulating BMI1 expression may be relevant to the role of BMI1 in promoting cancer and maintaining stem cell phenotype.	23239878
Specialty Type - cancer	Stem Cell Exhaustion	It is often overexpressed in cancer cells and is required for self-renewal of stem cells.	23239878
Fibrosis Assessment, Injury of liver	Stem Cell Exhaustion	During liver injury, their close proximity to hepatic progenitor cells and the ductular reaction may enable them to regulate liver repair and fibrosis.	23240894
Malignant Neoplasms	Stem Cell Exhaustion	Evaluation of 2009 pandemic H1N1 influenza vaccination in adults with lymphoid malignancies receiving chemotherapy or following autologous stem cell transplant.	23240909
Malignant Neoplasms	Stem Cell Exhaustion	Adults with a lymphoid malignancy receiving active systemic therapy, or within a year after autologous stem cell transplant, received one dose of AS03-adjuvanted A/California/7/2009 (H1N1) vaccine, and were randomized 21 days later to a second dose or no further vaccination.	23240909
Palmar-plantar erythrodysesthesia syndrome	Stem Cell Exhaustion	Using cytotoxic drugs with differential effects on hematopoietic stem cells, our data imply that chemotherapy-induced telomere shortening results from direct damage to hematopoietic stem cells and/or the induction of proliferative stress on bone marrow while sparing repopulating stem cells.	23240911
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is a clonal disorder arising from an alteration in multipotent stem cells, which lose the ability of normal proliferation and differentiation.	23240925
Dyskeratosis Congenita, Leukoencephalopathy	Stem Cell Exhaustion	Irreversible leukoencephalopathy after reduced-intensity stem cell transplantation in a dyskeratosis congenita patient with TINF2 mutation.	23242325
Dyskeratosis Congenita	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) for dyskeratosis congenita (DC) is challenging due to severe treatment-related adverse effects.	23242325
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Phase II study of central nervous system (CNS)-directed chemotherapy including high-dose chemotherapy with autologous stem cell transplantation for CNS relapse of aggressive lymphomas.	23242601
Carotid Stenosis	Stem Cell Exhaustion	To investigate the relationship between the changes in the number and function of the late endothelial progenitor cells (EPC) in peripheral blood and the carotid artery stenosis.	23242972
Adult Glioblastoma	Stem Cell Exhaustion	The CD133 antigen is a marker of radio- and chemo-resistant stem cell populations in glioblastoma (GBM).	23245659
Tears body substance	Stem Cell Exhaustion	Surgical repairs of tears in the vascular region of the meniscus usually heal better than repairs performed in the avascular region; thus, we hypothesized that this region might possess a richer supply of vascular-derived stem cells than the avascular region.	23247715
LIPC gene	Stem Cell Exhaustion	Patients with relapsed and refractory HL who were ineligible for autologous stem-cell transplantation (ASCT), or for whom this treatment failed, received bendamustine 120 mg/m(2) as a 30-minute infusion on days 1 and 2 every 28 days with growth factor support.	23248254
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Study of the quantitative, functional, cytogenetic, and immunoregulatory properties of bone marrow mesenchymal stem cells in patients with B-cell chronic lymphocytic leukemia.	23249221
Type II Mucolipidosis, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukemia (AML) is a life-threatening stem cell disease characterized by uncontrolled proliferation and accumulation of myeloblasts.	23249862
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Together, the BRD4-targeting drug JQ1 exerts major anti-leukemic effects in a broad range of human AML subtypes, including relapsed and refractory patients and all relevant stem- and progenitor cell compartments, including CD34+/CD38- and CD34+/CD38+ AML cells.	23249862
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia AML.	23249862
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	BRD4 was found to be expressed at the mRNA and protein level in unfractionated AML cells as well as in highly enriched CD34+/CD38- and CD34+/CD38+ stem- and progenitor cells in all patients examined.	23249862
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The introduction of tyrosine kinase inhibitors (TKIs) for chronic myeloid leukemia (CML) led to a dramatic change in the role of allogeneic stem cell transplantation (SCT) with a rapid decline in the number of patients receiving SCT in first chronic phase (CP1).	23250623
diabetic	Stem Cell Exhaustion	Global remodeling of the vascular stem cell niche in bone marrow of diabetic patients: implication of the microRNA-155/FOXO3a signaling pathway.	23250986
Primary adenocarcinoma of lung, Specialty Type - cancer	Stem Cell Exhaustion	Expression of the potential cancer stem cell markers, CD133, CD44, ALDH1, and b-catenin, in primary lung adenocarcinoma--their prognostic significance.	23252868
Spinal Muscular Atrophy	Stem Cell Exhaustion	Genetic correction of human induced pluripotent stem cells from patients with spinal muscular atrophy.	23253609
Small Nuclear Ribonucleoprotein Polypeptide F	Stem Cell Exhaustion	Induced pluripotent stem cells (iPSCs) generated from skin fibroblasts from SMA patients and genetically corrected have been proposed to be useful for autologous cell therapy.	23253609
Multiple Myeloma	Stem Cell Exhaustion	Sequential treatment with bortezomib plus dexamethasone followed by autologous hematopoietic stem cell transplantation in patients with multiple myeloma.	23253719
Multiple Myeloma	Stem Cell Exhaustion	Whether the sequential treatment with bortezomib plus dexamethasone (BD) followed by autologous hematopoietic stem cell transplantation (ASCT) could extend the overall survival period in multiple myeloma patients is still not clear.	23253719
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	One possible explanation is that cancer stem cells (CSCs) elude drug treatment, emerge and reproduce a tumor.	23254289
Glioblastoma Multiforme Pathway, Neoplasms	Stem Cell Exhaustion	Literature data indicate that glioma stem cells may give rise to both tumor cells and endothelial progenitor cells (EPCs).	23254765
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	The presence of genetic aberrations of glioma cells in intratumoral EPCs may point to transdifferentiation of glioma stem cells into EPCs.	23254765
Neoplasms	Stem Cell Exhaustion	Intratumoral, not circulating, endothelial progenitor cells share genetic aberrations with glial tumor cells.	23254765
Adult Glioblastoma, Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Cancer stem cell theory postulates that a small population of tumor-initiating cells is responsible for the development, progression and recurrence of several malignancies, including glioblastoma.	23255107
Adult Glioblastoma, Specialty Type - cancer	Stem Cell Exhaustion	Interestingly, analyzing by FACS the antiproliferative effects of metformin on CD133-expressing subpopulation, a component of glioblastoma cancer stem cells, a higher reduction of proliferation was observed as compared with CD133-negative cells, suggesting a certain degree of cancer stem cell selectivity in its effects.	23255107
Specialty Type - cancer, Childhood Breast Carcinoma, Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Metformin, a first-line drug for type II diabetes, was reported to possess anticancer properties affecting the survival of cancer stem cells in breast cancer models.	23255107
Adult Glioblastoma	Stem Cell Exhaustion	The specificity of metformin antiproliferative effects toward glioblastoma tumor-initiating cells was confirmed by the lack of significant inhibition of normal human stem cells (umbilical cord-derived mesenchymal stem cells) in vitro proliferation after metformin exposure.	23255107
Liver carcinoma, Disease, Metabolic Diseases, Specialty Type - cancer	Stem Cell Exhaustion	A number of marker genes for many diseases have been found in this chromosome, including genetic diseases (e.g., hepatocellular carcinoma) and biomedical research (cardiac system, aging, metabolic disorders, immune system, cancer and stem cell) related genes (e.g., oncogenes, growth factors).	23256888
Drusen	Stem Cell Exhaustion	This adult stem cell-based system using chronic TBHP treatment of hRPE represents a novel in vitro model useful for the study of drusen formation and dry AMD pathophysiology.	23257616
Endocrine System Diseases, Specialty Type - cancer	Stem Cell Exhaustion	The main risk factors for endocrine disease were male sex (hazard ratio (HR)=1.45, 95% confidence interval (95% CI) 1.05-1.99), radiotherapy (HR=1.91, 95% CI 1.28-2.84), hematopoietic stem cells transplantation (HR=3.11, 95% CI 2.23-4.34), and older age at cancer diagnosis (HR=1.89, 95% CI 1.25-2.85).	23258270
Medulloblastoma	Stem Cell Exhaustion	Reduced-dose craniospinal radiotherapy followed by tandem high-dose chemotherapy and autologous stem cell transplantation in patients with high-risk medulloblastoma.	23258845
Medulloblastoma	Stem Cell Exhaustion	We assessed the feasibility and effectiveness of reduced-dose craniospinal (CS) radiotherapy (RT) followed by tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/autoSCT) in reducing late adverse effects without jeopardizing survival among children with high-risk medulloblastoma (MB).	23258845
Adult Glioblastoma, Neoplasms	Stem Cell Exhaustion	On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells.	23262510
Neoplasms	Stem Cell Exhaustion	GBM-derived brain tumor stem cells (BTSCs) closely model this molecular heterogeneity and likely have a key role in tumor recurrence and therapeutic resistance.	23262510
Spastic Paraplegia, Hereditary	Stem Cell Exhaustion	A patient-derived stem cell model of hereditary spastic paraplegia with SPAST mutations.	23264559
Cardiomyopathies	Stem Cell Exhaustion	The Implantation of Autologous CD133(+) Stem Cells in Patients Undergoing CABG (IMPACT-CABG) trial is investigating the feasibility, safety, and efficacy of intramyocardial injections of autologous CD133(+) stem cells during coronary artery bypass grafting (CABG) in patients with chronic ischemic cardiomyopathy.	23265095
Cardiomyopathies	Stem Cell Exhaustion	This work represents the first Canadian experience with CD133(+) stem cells for the treatment of chronic ischemic cardiomyopathy.	23265095
Erythrocytosis	Stem Cell Exhaustion	Since erythrocytosis is the only feature that distinguishes PV from ET, we also compared specific miRNA expression in the nucleated erythroid cells directly descended from the early erythroid progenitor cells of PV and ET patients.	23265742
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Outcome of donor lymphocyte infusion after T cell-depleted allogeneic hematopoietic stem cell transplantation for acute myelogenous leukemia and myelodysplastic syndromes.	23266740
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Relapse occurs in 30%-50% of recipients of T cell-depleted (TCD) reduced-intensity conditioned (RIC) hematopoietic stem cell transplantation (HSCT) for acute myelogenous leukemia (AML) and myelodysplastic syndromes (MDS).	23266740
Childhood Breast Carcinoma	Stem Cell Exhaustion	Dynamics of circulating endothelial cells and endothelial progenitor cells in breast cancer patients receiving cytotoxic chemotherapy.	23268621
Multiple Myeloma	Stem Cell Exhaustion	Sleep measured by polysomnography in patients receiving high-dose chemotherapy for multiple myeloma prior to stem cell transplantation.	23269772
Multiple Myeloma	Stem Cell Exhaustion	To describe the objective sleep of patients receiving chemotherapy for multiple myeloma (MM) prior to stem cell transplantation.	23269772
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	It may be a good choice for patients with CML who cannot accept a hematopoietic stem cell transplant and imatinib or who fail IFN-a therapy.	23270584
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	It has been reported that chronic graft-versus-host disease (cGVHD) is associated with significant morbidity and mortality after allogeneic stem cell transplantation (allo-SCT).	23270984
Meningoencephalitis	Stem Cell Exhaustion	Detection of donor-derived CMV-specific T cells in cerebrospinal fluid in a case of CMV meningoencephalitis after cord blood stem cell transplantation.	23271411
Meningoencephalitis	Stem Cell Exhaustion	Cytomegalovirus (CMV) meningoencephalitis is a rather rare complication after allogeneic stem cell transplantation.	23271411
Neoplasms	Stem Cell Exhaustion	Using the BLT humanized mouse as a stem cell based gene therapy tumor model.	23271478
Immunocompromised Host	Stem Cell Exhaustion	In this model, 6 to 8 week old NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) immunocompromised mice receive the thy/liv implant as in the SCID-hu mouse model only to be followed by a second human hematopoietic stem cell transplant (4).	23271478
Febrile Neutropenia, Acute leukemia	Stem Cell Exhaustion	In a double-blind, placebo-controlled, multicenter study, patients with acute leukemia undergoing chemotherapy or allogeneic hematopoietic stem cell transplantation (HSCT) recipients were randomized to broad-spectrum antibacterial therapy plus voriconazole (immediate) or placebo (deferred) after the onset of neutropenic fever.	23271674
Chemical injury	Stem Cell Exhaustion	Effective progenitor cell recruitment to the ischemic injury zone is a prerequisite for any potential therapeutic effect.	23271789
Proteinuria, Pneumonitis, CTCAE, Purpura, Thrombotic Thrombocytopenic, Cystitis	Stem Cell Exhaustion	Pneumonitis (n=5) or proteinuria over 1.5 g per day (n=13) were only observed in kidney transplant patients, while polyomavirus-induced cystitis (n=3) and thrombotic thrombocytopenic purpura (n=7) were only observed in stem cell transplanted patients.	23274324
Fever	Stem Cell Exhaustion	Forty-four febrile neutropaenic patients, following haematopoietic stem cell transplantation (HSCT) and with multi-lumen CVCs in place, were investigated using the DTP method of blood samples drawn from every lumen of the CVC and a peripheral vein.	23274928
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Prognostic impact of allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia patients with internal tandem duplication of FLT3.	23276395
FLT3 Internal Tandem Duplication, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The FLT3 gene with internal tandem duplication (ITD) is a poor prognostic factor in patients with acute myeloid leukemia (AML), and the efficacy of allogeneic hematopoietic stem cell transplantation (HSCT) for AML patients with FLT3-ITD is controversial.	23276395
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Clofarabine does not negatively impact the outcomes of patients with acute myeloid leukemia undergoing allogeneic stem cell transplantation.	23276886
Toxic liver disease, Venoocclusive disease	Stem Cell Exhaustion	We evaluated whether clofarabine-containing chemotherapy predisposed patients to hepatic toxicity (particularly venoocclusive disease [VOD]) after allogeneic stem cell transplantation (allo-SCT).	23276886
Hepatotoxicity, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Many patients with AML undergo allogeneic stem cell transplantation (allo-SCT), a procedure that is also associated with hepatotoxicity.	23276886
B-Cell Lymphomas, Lymphoma	Stem Cell Exhaustion	Prognostic factors for patients with diffuse large B cell lymphoma and transformed indolent lymphoma undergoing autologous stem cell transplantation in the positron emission tomography era.	23278720
B-Cell Lymphomas, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	In the positron emission tomography (PET) era, traditional prognostic factors may not apply for patients with relapsed/refractory (R/R) diffuse large B cell lymphoma (DLBCL) undergoing autologous stem cell transplantation (ASCT).	23278720
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GvHD) is a common complication following haematopoietic stem cell transplant but little is published about the impact of this condition on hospital readmission rates.	23278853
Infection, Microbiological, Amyloidosis	Stem Cell Exhaustion	Microbiologically documented infections in patients undergoing high-dose melphalan and autologous stem cell transplantation for the treatment of light chain amyloidosis.	23279695
Amyloidosis	Stem Cell Exhaustion	Immunoglobulin light chain (AL) amyloidosis can be treated with high-dose melphalan and autologous stem cell transplantation (HDM/SCT).	23279695
Disease, Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH) is a unique disorder caused by a PIG-A gene mutation in a stem cell clone.	23281097
Muscular Dystrophy, Dilated Cardiomyopathy Pathway	Stem Cell Exhaustion	Injection of vessel-derived stem cells prevents dilated cardiomyopathy and promotes angiogenesis and endogenous cardiac stem cell proliferation in mdx/utrn-/- but not aged mdx mouse models for duchenne muscular dystrophy.	23283493
Doctor of Chiropractic, Myocardium	Stem Cell Exhaustion	In summary, ADMs delay or prevent development of DCM in dystrophin-deficient heart, but timing of stem cell transplantation may be critical for achieving benefit with cell therapy in DMD cardiac muscle.	23283493
Muscular Dystrophy, Duchenne, Doctor of Chiropractic	Stem Cell Exhaustion	We hypothesized that mesoangioblast stem cells (aorta-derived mesoangioblasts [ADMs]) would restore dystrophin and alleviate or prevent DCM in animal models of DMD.	23283493
Illness (finding)	Stem Cell Exhaustion	Human rhinovirus C in adult haematopoietic stem cell transplant recipients with respiratory illness.	23290385
Ischemic stroke	Stem Cell Exhaustion	Ischaemic stroke induces endothelial progenitor cell (EPC) mobilisation from bone marrow into peripheral blood.	23290569
Hemorrhagic, Ischemic stroke	Stem Cell Exhaustion	Increased circulating endothelial progenitor cells in patients with haemorrhagic and ischaemic stroke: the role of endothelin-1.	23290569
Ischemia, Corneal Endothelial Cell Loss	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPCs) are recruited from the blood system to sites of ischemia and endothelial damage, where they contribute to the repair and development of blood vessels.	23291334
Multiple Myeloma	Stem Cell Exhaustion	Evaluation of the feasibility and efficacy of autologous stem cell transplantation in elderly patients with multiple myeloma.	23291675
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The feasibility and efficacy of high-dose melphalan (HD-MEL) followed by autologous hematopoietic stem cell transplantation (auto-SCT) in elderly patients with multiple myeloma (MM) are discussed.	23291675
Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	Thus, we propose that stromal cell-mediated delivery of TNFa to human tumors [using transfected fibroblasts or mesenchymal stem cells (hMSCs)] may be a novel and effective strategy for the prevention and treatment of human cancers.	23292149
Malignant Neoplasms	Stem Cell Exhaustion	Intermediate-dose Ara-C plus G-CSF for stem cell mobilization in patients with lymphoid malignancies, including predicted poor mobilizers.	23292239
Malignant Neoplasms	Stem Cell Exhaustion	The optimal protocol for mobilization of hematopoietic stem cells in patients with lymphoid malignancies has not been determined so far.	23292239
Glioblastoma Multiforme Pathway, Glioma, Adult Glioblastoma	Stem Cell Exhaustion	More recently, it has been reported that miR-326 was down-regulated in glioblastoma tissues and might regulate the metabolic activity of glioma and glioma stem cells, suggesting the involvement of miR-326 in tumorigenesis and progression of gliomas.	23292865
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	Hodgkin's Lymphoma (HL) is highly chemoresponsive, and majority of patients respond to therapy except for a small number which require high-dose therapy and stem cell rescue for salvage.	23292874
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We assessed WT1 expression (expressed as messenger copies/10(4) ABL1) from marrow cells of 122 patients with acute myeloid leukaemia (AML), before and after an unmanipulated allogeneic haemopoietic stem cell transplant (HSCT).	23294252
Diabetes Mellitus	Stem Cell Exhaustion	Diabetes mellitus after allogeneic hematopoietic stem cell transplantation.	23296512
No endocrine abnormalities, Dominica, Diabetes Mellitus	Stem Cell Exhaustion	Survivors of pediatric hematopoietic stem cell transplantation (HSCT) are known to be at risk of developing endocrine abnormalities, but occurrence of diabetes mellitus (DM) is a relatively recent observation.	23296512
Hepatic Veno-Occlusive Disease	Stem Cell Exhaustion	Tolvaptan as an alternative treatment for refractory fluid retention associated with sinusoidal obstruction syndrome after allogeneic stem cell transplantation.	23297121
Precursor T-cell lymphoblastic lymphoma	Stem Cell Exhaustion	A 42-year-old male with primarily refractory T-lymphoblastic lymphoma underwent allogeneic peripheral blood stem cell transplantation from an HLA-matched sibling donor.	23297121
Post-transplant lymphoproliferative disorder, Primary Myelofibrosis	Stem Cell Exhaustion	Case 2-2012: a 57-year-old woman with post-transplant lymphoproliferative disorder after allogeneic stem cell transplantation for primary myelofibrosis.	23297524
Failure, Glaucoma, CTCAE	Stem Cell Exhaustion	Most patients will need treatment for glaucoma and some may require treatment for tear-film instability and/or stem cell failure.	23298884
leukemia	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HSCT) from a human leukocyte antigen (HLA)-haploidentical family donor (haplo-HSCT) is a readily available and potentially curative option for high-risk leukemia.	23299798
Myeloproliferative disease	Stem Cell Exhaustion	JAK2 p.V617F allele burden in myeloproliferative neoplasms one month after allogeneic stem cell transplantation significantly predicts outcome and risk of relapse.	23300178
Primary central nervous system lymphoma	Stem Cell Exhaustion	Prognosis of patients with primary central nervous system lymphoma after high-dose chemotherapy followed by autologous stem cell transplantation.	23300179
Primary central nervous system lymphoma	Stem Cell Exhaustion	High-dose chemotherapy followed by autologous stem cell transplantation has been shown to be feasible and highly effective in newly diagnosed primary central nervous system lymphoma.	23300179
Primary central nervous system lymphoma	Stem Cell Exhaustion	We retrospectively analyzed 105 immunocompetent patients with primary central nervous system lymphoma who underwent high-dose chemotherapy followed by autologous stem cell transplantation with or without whole brain radiotherapy as first-line consolidation treated at 12 German centers between 1997 and 2011.	23300179
Primary central nervous system lymphoma	Stem Cell Exhaustion	High-dose chemotherapy followed by autologous stem cell transplantation is a highly effective and safe treatment modality for selected primary central nervous system lymphoma patients.	23300179
Aortic Aneurysm	Stem Cell Exhaustion	Interestingly Jagged1, NICD, and Hes1 were highly present in CD34+ stem cells and Stro-1+ stem cells in aortas from TAA and TAD patients.	23300792
Choroid Plexus Carcinoma	Stem Cell Exhaustion	Successful treatment of a recurrent choroid plexus carcinoma with surgery followed by high-dose chemotherapy and stem cell rescue.	23301664
TP53 gene, "cytidylyl-(3-5)-cytidine	Stem Cell Exhaustion	The authors report long-term survival of a 1-year-old patient with recurrent CPC and Li-Fraumeni syndrome with surgical resection and high-dose chemotherapy (HDC) consisting of single cycle of Busulfan and Thiotepa followed by autologous stem cell rescue without the use of radiation therapy.	23301664
cytidylyl-(3-5)-cytidine	Stem Cell Exhaustion	Additional studies are necessary to determine the role of HDC and stem cell rescue in patients with recurrent CPC.	23301664
Myeloid Leukemia	Stem Cell Exhaustion	[Efficacy of allogeneic hematopoietic stem cell transplantation in treatment of childhood myelogenous leukemia: the observation of 24 cases].	23302609
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	To retrospectively analyze the effects of allogeneic hematopoietic stem cell transplantation (allo-HSCT) on childhood chronic myelogenous leukemia (CML).	23302609
Specialty Type - cancer	Stem Cell Exhaustion	Changes in nutritional status, body composition, quality of life, and physical activity levels of cancer patients undergoing autologous peripheral blood stem cell transplantation.	23306934
Specialty Type - cancer	Stem Cell Exhaustion	This pilot exploratory study aimed to describe the changes in nutritional status, body composition, quality of life (QoL), and physical activity levels (PAL) of cancer patients undergoing high-dose conditioning and autologous peripheral blood stem cell transplantation (PBSCT) at pre-admission, hospital discharge, and at 100 days post-transplantation, and to examine if changes in these parameters are interrelated.	23306934
Ischemia	Stem Cell Exhaustion	Intra-arterial allogeneic mesenchymal stem cells for critical limb ischemia are safe and efficacious: report of a phase I study.	23307180
Specialty Type - cancer, Neoplasms, Secondary Neoplasm, Carcinogenesis	Stem Cell Exhaustion	According to the cancer stem cell (CSC) theory, the overexpression of Sox2 is potentially involved in carcinogenesis and could affect tumor recurrence and metastasis.	23307254
Ischemia	Stem Cell Exhaustion	Molecular imaging of the paracrine proangiogenic effects of progenitor cell therapy in limb ischemia.	23307829
Ischemia	Stem Cell Exhaustion	Using molecular imaging, we tested the hypothesis that treatment of limb ischemia with multipotential adult progenitor cells (MAPCs) promotes recovery of blood flow through the recruitment of proangiogenic monocytes.	23307829
Colonization	Stem Cell Exhaustion	Microbiology and epidemiology of oral yeast colonization in hemopoietic progenitor cell transplant recipients.	23312542
Colonization, Stomatitis	Stem Cell Exhaustion	We monitored the epidemiology and microbiology of oral yeast colonization in patients undergoing hemopoietic progenitor cell transplantation (HPCT) to examine associations between yeast colonization and oral mucositis.	23312542
Diffuse alveolar hemorrhage, Hematologic Neoplasms	Stem Cell Exhaustion	To analyze high-resolution computed tomography (HRCT) patterns of lung involvement and disease course in patients with hematological malignancies experiencing diffuse alveolar hemorrhage (DAH) after chemotherapy +- allogeneic stem cell transplantation (allo-SCT).	23313188
Adult Glioblastoma, Specialty Type - cancer	Stem Cell Exhaustion	PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line.	23314408
Adult Glioblastoma	Stem Cell Exhaustion	Here, ectopic expression of PTEN in the U-87MG human glioblastoma-astrocytoma cell line is shown to result in the depletion of glioblastoma stem cells (GSCs) and to cause growth retardation and senescence.	23314408
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Azacitidine and donor lymphocyte infusions as first salvage therapy for relapse of AML or MDS after allogeneic stem cell transplantation.	23314834
Neoplasms, SERPINB3 wt Allele, Specialty Type - cancer	Stem Cell Exhaustion	Tumour cells of a putative CD44+ cancer stem cell compartment express VDR indicating a potential Achilles' heel for the treatment of OSCC although, our results do not allow any conclusion on the function of VDR.	23314953
Specialty Type - cancer	Stem Cell Exhaustion	Vitrification has been proposed as a promising technique for long-term storage of ITT, with a view to preserving spermatogonial stem cells (SSCs) for future fertility restoration in young boys suffering from cancer.	23315062
Aplastic Anemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Individual hematopoietic stem cells in human bone marrow of patients with aplastic anemia or myelodysplastic syndrome stably give rise to limited cell lineages.	23316019
Specialty Type - cancer	Stem Cell Exhaustion	Induction of cells with cancer stem cell properties from nontumorigenic human mammary epithelial cells by defined reprogramming factors.	23318426
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSCs), a small and elusive population of undifferentiated cancer cells within tumors that drive tumor growth and recurrence, are believed to resemble normal stem cells.	23318426
HD Term Type, filgrastim	Stem Cell Exhaustion	The human recombinant G-CSF filgrastim has been widely used for the mobilization of CD34(+) stem cells of healthy donors (HD).	23318540
Richters syndrome", Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Successful allogeneic hematopoietic stem cell transplantation in a young patient with Richter syndrome presenting with chronic lymphocytic leukemia and diffuse large B-cell lymphoma with different cell origins.	23318862
Aplastic Anemia, CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology	Stem Cell Exhaustion	Antithymocyte globulin (ATG) is the drug of choice for immunosuppressive therapy (IST) in patients with severe aplastic anemia (SAA) ineligible for allogeneic stem cell transplantation.	23318980
Adult Glioblastoma	Stem Cell Exhaustion	CD133/CD15 defines distinct cell subpopulations with differential in vitro clonogenic activity and stem cell-related gene expression profile in in vitro propagated glioblastoma multiforme-derived cell line with a PNET-like component.	23319191
Neoplasms	Stem Cell Exhaustion	However, a unique immunophenotype/surface antigen composition for the clear identification of brain tumour stem cells (BTSC) has not yet been found.	23319191
Leukemia, Myelomonocytic, Chronic	Stem Cell Exhaustion	Allogeneic stem cell transplantation for chronic myelomonocytic leukemia: a report from the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire.	23320648
Leukemia, Myelomonocytic, Chronic	Stem Cell Exhaustion	Chronic myelomonocytic leukemia (CMML) is a severe disease for which allogeneic stem cell transplantation (allo-SCT) remains the only potentially curative treatment.	23320648
Leukemia, Myelomonocytic, Chronic	Stem Cell Exhaustion	Allogeneic stem cell transplantation is a valid treatment option for patients with CMML, and its outcome has improved with YOT > 2004.	23320648
Carcinoma, Papillary, Specialty Type - cancer, Papilloma	Stem Cell Exhaustion	In addition, our data suggest that cyclin D1 is expressed only in the cancer stem or progenitor cells that co-immunostained with CK 8/18 in papillary carcinomas, and predominantly with CK 8/18 in the papillomas.	23327593
Exfoliative dermatitis, Omenn Syndrome	Stem Cell Exhaustion	A 4-month-old girl diagnosed with Omenn syndrome, a subtype of severe combined immunodeficiency presenting with generalized erythroderma, was referred to our hospital for an allogeneic stem cell transplantation.	23328788
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Impact of malignant stem cell burden on therapy outcome in newly diagnosed chronic myeloid leukemia patients.	23328954
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myeloid leukemia (CML) stem cells appear resistant to tyrosine kinase inhibitors (TKIs) in vitro, but their impact and drug sensitivity in vivo has not been systematically assessed.	23328954
Philadelphia chromosome positive chronic myelogenous leukemia, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We prospectively analyzed the proportion of Philadelphia chromosome-positive leukemic stem cells (LSCs, Ph+CD34+CD38-) and progenitor cells (LPCs, Ph+CD34+CD38+) from 46 newly diagnosed CML patients both at the diagnosis and during imatinib or dasatinib therapy (ClinicalTrials.gov NCT00852566).	23328954
Hematologic Neoplasms	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) is an efficacious treatment for many hematologic malignancies.	23329358
CLU protein, human, Ischemia, diabetic	Stem Cell Exhaustion	The efficacy and safety of transplanting autologous mesenchymal stem cells (MSCs), from granulocyte-colony-stimulating factor (G-CSF)-mobilised peripheral blood, was investigated in diabetic patients with critical limb ischaemia (CLI).	23329572
Pure Red-Cell Aplasia	Stem Cell Exhaustion	We estimated the incidence and described the natural history of PRCA in patients with major ABO-mismatched donor stem cells.	23330820
Pure Red-Cell Aplasia	Stem Cell Exhaustion	Between 2007 and 2008, 161 (27% of all patients undergoing HSCT) underwent allogeneic HSCT with major ABO-mismatched stem cells and 12 (7*5%) of these patients developed PRCA.	23330820
Encephalitis	Stem Cell Exhaustion	Human herpesvirus-6 encephalitis during hematopoietic stem cell transplantation leads to poor prognosis.	23331378
Encephalitis, Infection	Stem Cell Exhaustion	Indications for the application of hematopoietic stem cell transplantation (HSCT) from alternative donors have remarkably broadened in scope; however, the incidence of infections that lead to failure of HSCT, such as human herpesvirus-6 (HHV-6) encephalitis, has also increased.	23331378
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	The cancer stem cell marker aldehyde dehydrogenase 1 (ALDH1) associates with treatment resistance and adverse outcome in several human cancers.	23332924
TCL4 gene, Pregnancy Complications, Infectious	Stem Cell Exhaustion	Distinct clinical features of infectious complications in adult T cell leukemia/lymphoma patients after allogeneic hematopoietic stem cell transplantation: a retrospective analysis in the Nagasaki transplant group.	23333533
HOX11 protein, TRPV6 wt Allele	Stem Cell Exhaustion	Although allogeneic hematopoietic stem cell transplantation (allo-SCT) is performed as a curative option in adult T cell leukemia-lymphoma (ATL) patients, its high transplantation-related mortality raises a serious issue.	23333533
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	The superiority of plerixafor + granulocyte colony-stimulating factor (G-CSF) over placebo + G-CSF for hematopoietic stem cell mobilization and collection was shown for patients with non-Hodgkin lymphoma in a phase III, prospective, randomized, controlled study.	23333777
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Plerixafor plus granulocyte colony-stimulating factor improves the mobilization of hematopoietic stem cells in patients with non-Hodgkin lymphoma and low circulating peripheral blood CD34+ cells.	23333777
Specialty Type - cancer, Multiple Myeloma	Stem Cell Exhaustion	Factors impacting stem cell mobilization failure rate and efficiency in multiple myeloma in the era of novel therapies: experience at Memorial Sloan Kettering Cancer Center.	23334269
Failure	Stem Cell Exhaustion	Among 317 patients who proceeded to stem cell collection after induction therapy between 2000 and 2009, the rate of mobilization failure, defined as the inability to collect 5 x 10(6) CD34+ cells/kg following the first collection attempt, was 13%.	23334269
Hematopoietic stem cells	Stem Cell Exhaustion	Plasma exchange of the recipient is a safe method of managing donor-recipient major ABO incompatibility before BMT without the risk of haematopoietic progenitor cell loss associated with red cell depletion of the graft.	23334277
Neoplasms	Stem Cell Exhaustion	It is unclear how adult stem cells in solid organs respond to oncogenic stimulation and whether these cells have a role in tumor initiation.	23334329
Specialty Type - cancer, Pancreatic carcinoma	Stem Cell Exhaustion	The use of a novel MUC1 antibody to identify cancer stem cells and circulating MUC1 in mice and patients with pancreatic cancer.	23335066
Specialty Type - cancer	Stem Cell Exhaustion	Development of novel approaches for detection and/or targeting of MUC1 are critically needed and should be able to detect MUC1 on PC cells (including cancer stem cells) and in serum.	23335066
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	PI-103 sensitizes acute myeloid leukemia stem cells to daunorubicin-induced cytotoxicity.	23335068
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Leukemia stem cells (LSCs) are insensitive to conventional chemotherapeutic drugs and play a central role in the pathogenesis of AML.	23335068
Minimal Disseminated Disease	Stem Cell Exhaustion	Localized bone lesions require irradiation, whereas young patients with disseminated disease receive intensive treatment with stem cell support.	23335406
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	[Therapeutic efficacy of allogeneic hematopoietic stem cell transplantation in children with chronic myelogenous leukemia].	23336162
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	To investigate the therapeutic efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in children with chronic myelogenous leukemia (CML), and to analyze the possible prognostic factors.	23336162
Pelvic Organ Prolapse	Stem Cell Exhaustion	We aimed to derive induced pluripotent stem cell (iPSC) lines from vaginal fibroblasts from older women with pelvic organ prolapse.	23341439
Amyotrophic Lateral Sclerosis	Stem Cell Exhaustion	Differentiation of CD133+ stem cells from amyotrophic lateral sclerosis patients into preneuron cells.	23341441
Amyotrophic Lateral Sclerosis, Antilymphocyte Serum	Stem Cell Exhaustion	Improvements in quality of life and life expectancy have been observed in amyotrophic lateral sclerosis (ALS) patients transplanted with CD133(+) stem cells into their frontal motor cortices.	23341441
Antilymphocyte Serum	Stem Cell Exhaustion	The objective of this work was to evaluate the in vitro capacity of CD133(+) stem cells from 13 ALS patients to differentiate into neuron lineage.	23341441
Antilymphocyte Serum	Stem Cell Exhaustion	Fluorescence microscopy demonstrated that CD133(+) stem cells from ALS patients incubated for 48 hours in a neuroinduction medium increased the detection of neuronal proteins such as nestin, b-tubulin III, neuronal-specific enolase, and glial fibrillary acidic protein.	23341441
Antilymphocyte Serum	Stem Cell Exhaustion	We conclude that CD133(+) stem cells from ALS patients, like the stem cells of healthy subjects, are capable of differentiating into preneuron cells.	23341441
Multiple Myeloma	Stem Cell Exhaustion	Early response to bortezomib combined chemotherapy can help predict survival in patients with multiple myeloma who are ineligible for stem cell transplantation.	23341716
Idiopathic Pulmonary Fibrosis	Stem Cell Exhaustion	Endothelial progenitor cells in the pathogenesis of idiopathic pulmonary fibrosis: an evolving concept.	23341966
diabetic, Foot Diseases	Stem Cell Exhaustion	This study was designed to evaluate the distribution of Tregs/Th17/Th1 cells in type 2 diabetic patients with foot disease before and after human umbilical cord blood mesenchymal stem cell (hUCB-MSCs) transplantation.	23343120
Umbilical Cord Blood-Derived Mesenchymal Stem Cells, Immunology, Foot Diseases, Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Treatment of foot disease in patients with type 2 diabetes mellitus using human umbilical cord blood mesenchymal stem cells: response and correction of immunological anomalies.	23343120
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation versus hypomethylating agents in patients with myelodysplastic syndrome: a retrospective case-control study.	23345254
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic stem cell transplantation (allo-SCT) is the only potentially curative treatment for myelodysplastic syndrome (MDS).	23345254
Pancytopenia	Stem Cell Exhaustion	Treatment at home during the pancytopenic phase after allogeneic hematopoietic stem cell transplantation (HSCT) has been an option for patients at our center since 1998.	23347992
Mycoses	Stem Cell Exhaustion	Invasive fungal infections are a major cause of morbidity and mortality in hematopoietic stem cell transplantation patients.	23350288
Fusariosis	Stem Cell Exhaustion	We report a case of invasive Fusarium infection involving the nasopharynx, skin and lungs, following haploidentical hematopoietic stem cell transplantation in an 8-year old patient with recurrent leukemia.	23350288
Malignant tumor of colon	Stem Cell Exhaustion	MicroRNA-93 (miR-93) has been shown to suppress proliferation and colony formation of colon cancer stem cells.	23354160
Neoplasms	Stem Cell Exhaustion	We found that CD44(+)/aldehyde dehydrogenase (ALDH)(+) slowly proliferating immature CRC stem cell populations expressed relatively low levels of JARID1B and the differentiation marker, CD20, as well as relatively high levels of the tumor suppressor, p16/INK4A.	23354547
Specialty Type - cancer, Secondary Neoplasm, Cytogenetic Complete Response	Stem Cell Exhaustion	Although there are emerging epigenetic factors that contribute to the occurrence, development and metastasis of CRC, the biological significance of epigenetic molecular regulation in different subpopulations such as cancer stem cells remains to be elucidated.	23354547
diabetic, Corneal Endothelial Cell Loss	Stem Cell Exhaustion	Eighteen "responder" and twelve "non responder" type 2 diabetic patients were evaluated, relatively to different levels of endothelial damage, through the diagnostic use of a new immunophenotype of circulating endothelial progenitor cells (CD45neg/CD34pos/CD144pos) and endothelial microparticles (CD45neg/CD144pos/Annexin Vpos), recently developed and published by our group.	23357410
Penile arterial insufficiency, Erectile dysfunction	Stem Cell Exhaustion	"Non responder" patients showed a significant higher severity [8.0+-3.0 (International Index of Erectile Function-abbreviated version with 5 questions) vs 14.0+-3.0] and duration (10.0+-2.0 vs 7.0+-2.0 years) of erectile dysfunction, higher level of penile arterial insufficiency (peak systolic velocity=13.0+-16.0 vs 28.0+-26.0cm/s; acceleration time=153+-148 vs 125+-128 mm/s) and finally a significant higher level of endothelial apoptosis [0.15+-0.13 vs 0.05+-.0.03% (serum concentrations of endothelial microparticles)] associated with higher serum concentrations of circulating late immunophenotype of endothelial progenitor cells (0.40+-0.35 vs 0.12+-.0.10%).	23357410
Multiple Myeloma	Stem Cell Exhaustion	Overcoming the response plateau in multiple myeloma: a novel bortezomib-based strategy for secondary induction and high-yield CD34+ stem cell mobilization.	23357980
Multiple Myeloma	Stem Cell Exhaustion	This phase II study evaluated bortezomib-based secondary induction and stem cell mobilization in 38 transplant-eligible patients with myeloma who had an incomplete and stalled response to, or had relapsed after, previous immunomodulatory drug-based induction.	23357980
Neoplasms	Stem Cell Exhaustion	Bortezomib-based secondary induction and mobilization could represent an alternative strategy for elimination of tumor burden in immunomodulatory drug-resistant patients that does not impact stem cell yield.	23357980
Gray Platelet Syndrome	Stem Cell Exhaustion	Successful hematopoietic engraftment with gray platelets after allogeneic hematopoietic stem cell transplantation from gray platelet syndrome donor.	23358204
Acute lymphocytic leukemia	Stem Cell Exhaustion	A 19-year old female patient with her second relapse acute lymphoblastic leukemia had to be consolidated with allo-hematopoietic stem cell transplantation (HSCT) after achieving remission with induction chemotherapy.	23358204
Childhood Breast Carcinoma	Stem Cell Exhaustion	Our previous work showed thiotepa could eradicate breast cancer stem cells.	23359185
Arca	Stem Cell Exhaustion	Comparative analysis of circulating endothelial progenitor cells in age-related macular degeneration patients using automated rare cell analysis (ARCA) and fluorescence activated cell sorting (FACS).	23359346
Idiopathic pneumonia syndrome	Stem Cell Exhaustion	Successful use of extracorporeal membrane oxygenation in a hematopoietic stem cell transplant patient with idiopathic pneumonia syndrome.	23359731
Allogeneic Hematopoietic Stem Cell Transplantation, Idiopathic pneumonia syndrome	Stem Cell Exhaustion	We report the case of an adult patient with idiopathic pneumonia syndrome following allogeneic hematopoietic stem cell transplantation, which was successfully managed with venovenous extracorporeal membrane oxygenation (ECMO) and immunosuppressive therapy.	23359731
leukemia	Stem Cell Exhaustion	He underwent allogeneic hematopoietic stem cell transplantation 4 months prior to enrollment, owing to leukemia relapse.	23359731
T-Cell Lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation for enteropathy-associated T-cell lymphoma: a retrospective study by the EBMT.	23361910
TRPV6 wt Allele	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) was retrospectively evaluated as a consolidation or salvage strategy for EATL.	23361910
Vascular System Injuries	Stem Cell Exhaustion	Vessel injury was observed in a total of 9 procedures (1.2%) and could be promptly managed by additional progenitor cell injection (PCI) in all but 1 case.	23362308
Chronic heart failure, Acute myocardial infarction	Stem Cell Exhaustion	Procedural safety and predictors of acute outcome of intracoronary administration of progenitor cells in 775 consecutive procedures performed for acute myocardial infarction or chronic heart failure.	23362308
Congestive heart failure, Acute myocardial infarction	Stem Cell Exhaustion	Intracoronary infusion of progenitor cells can be performed with adequate safety in patients with acute myocardial infarction or CHF, because the safety profile was similar to what is usually expected from a coronary angiogram in the present cohort.	23362308
TNF protein, human	Stem Cell Exhaustion	PFS was inversely correlated with baseline levels of VEGF, sVEGFR2, and bFGF and with on-treatment levels of bFGF and IGF-1, and directly associated with on-treatment levels of IFN-g. OS was inversely correlated with baseline levels of sVEGFR1, Ang-2, TNF-a, CAIX, and CD34(+)CD133(+)CD45(dim) circulating progenitor cells and on-treatment levels of sVEGFR2.	23362324
Specialty Type - cancer	Stem Cell Exhaustion	Human cancer cells resemble stem cells in expression signatures leading them to share some features, most notably, self-renewal.	23363002
Colorectal Neoplasms	Stem Cell Exhaustion	SALL4 is a zinc finger transcriptional activator crucial for maintenance of self-renewal in stem cells; however, its expression level has not yet been elucidated in colorectal tumor cells.	23363002
Systemic Scleroderma	Stem Cell Exhaustion	Cardiac involvement and treatment-related mortality after non-myeloablative haemopoietic stem-cell transplantation with unselected autologous peripheral blood for patients with systemic sclerosis: a retrospective analysis.	23363664
Failure, Systemic Scleroderma	Stem Cell Exhaustion	Autologous haemopoietic stem-cell transplantation (HSCT) benefits patients with systemic sclerosis but has been associated with significant treatment-related mortality and failure to improve diffusion capacity of carbon monoxide (DLCO).	23363664
Acute leukemia	Stem Cell Exhaustion	[Outcome of haploidentical hematopoietic stem cell transplantation for refractory/relapsed acute leukemia].	23363748
Acute leukemia	Stem Cell Exhaustion	To explore the outcome of human leukocyte antigen (HLA)-mismatched/haploidentical hematopoietic stem cell transplantation (HSCT) for refractory/relapsed acute leukemia (AL) patients and its related risk factors.	23363748
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	This study was aimed to investigate whether incorporation of rituximab into high-dose chemotherapy with autologous peripheral blood stem cell transplantation (auto-PBSCT)could improve the survival of patients with diffuse large B-cell lymphoma (DLBCL), and evaluate the safety of this regimen.	23363798
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Twenty-five patients (age, 17 - 61 yrs) with DLBCL were treated with a sequential chemotherapy for remission induction, intensive chemotherapy for mobilization of stem cells, and high-dose chemotherapy followed by auto-PBSCT.	23363798
Bulbo-Spinal Atrophy, X-Linked	Stem Cell Exhaustion	Enhanced aggregation of androgen receptor in induced pluripotent stem cell-derived neurons from spinal and bulbar muscular atrophy.	23364790
Disease	Stem Cell Exhaustion	Induced pluripotent stem cells (iPSCs) are a new technology that can be used to model human diseases, study pathogenic mechanisms, and develop novel drugs.	23364790
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	To analyse the outcome of adult patients who developed a first relapse of acute lymphoblastic leukaemia (ALL), we collected the clinical data of 332 patients with Philadelphia-chromosome (Ph) negative ALL, aged 16-65 years, who relapsed after first complete remission (CR1) between 1998 and 2008 in 69 institutions all over Japan, including 58 patients who relapsed after allogeneic haematopoietic stem cell transplantation (Allo-HSCT) in CR1.	23368421
Specialty Type - cancer	Stem Cell Exhaustion	Using crude EVOO phenolic extracts highly enriched in the secoiridoids oleuropein aglycon and decarboxymethyl oleuropein aglycon, we show for the first time that (1) the anticancer activity of EVOO secoiridoids is related to the activation of anti-aging/cellular stress-like gene signatures, including endoplasmic reticulum (ER) stress and the unfolded protein response, spermidine and polyamine metabolism, sirtuin-1 (SIRT1) and NRF2 signaling; (2) EVOO secoiridoids activate AMPK and suppress crucial genes involved in the Warburg effect and the self-renewal capacity of "immortal" cancer stem cells; (3) EVOO secoiridoids prevent age-related changes in the cell size, morphological heterogeneity, arrayed cell arrangement and senescence-associated b-galactosidase staining of normal diploid human fibroblasts at the end of their proliferative lifespans.	23370395
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	We aimed to clarify the impact of the donor source of allogeneic stem cell transplantation (allo-SCT) on Philadelphia chromosome-negative acute lymphoblastic leukemia [Ph(-) ALL] with focus on cord blood (CB).	23372050
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	Because in PNH the biosynthesis of the glycolipid molecule glycosylphosphatidylinositol (GPI) is disrupted in hematopoietic stem and progenitor cells by a somatic mutation in the PIG-A gene, BMF might result from an autoimmune attack, whereby T cells target GPI in normal cells, whereas PIG-A mutant GPI-negative cells are spared.	23372165
Degenerative polyarthritis	Stem Cell Exhaustion	Mesenchymal stem cell injections improve symptoms of knee osteoarthritis.	23375182
Degenerative polyarthritis	Stem Cell Exhaustion	The purpose of this study was to evaluate the clinical and imaging results of patients who received intra-articular injections of autologous mesenchymal stem cells for the treatment of knee osteoarthritis.	23375182
Degenerative polyarthritis, Usual Severity Pain	Stem Cell Exhaustion	The results of our study are encouraging and show that intra-articular injection of infrapatellar fat pad-derived mesenchymal stem cells is effective for reducing pain and improving knee function in patients being treated for knee osteoarthritis.	23375182
Pseudarthrosis	Stem Cell Exhaustion	Treatment of pseudoarthrosis of the upper limb using expanded mesenchymal stem cells: a pilot study.	23377812
Heart failure, Cessation of life	Stem Cell Exhaustion	Comparison of the Seattle heart failure model and cardiopulmonary exercise capacity for prediction of death in patients with chronic ischemic heart failure and intracoronary progenitor cell application.	23377956
Heart failure	Stem Cell Exhaustion	One hundred fifty-seven patients with ischemic heart failure and recent intracoronary progenitor cell application were analyzed for mortality during a follow-up of 4 years.	23377956
Gastric Antral Vascular Ectasia, Gastrointestinal Hemorrhage, Agave	Stem Cell Exhaustion	Gastric antral vascular ectasia (GAVE) leading to upper gastrointestinal bleeding is a heterogeneous disorder that is not commonly recognized in hematopoietic stem cell transplantation (HSCT).	23378184
Inflammation	Stem Cell Exhaustion	S100 proteins, and in particular S100 A4 and S100 A9, can be useful as markers of early changes in stem cell niches due to inflammation.	23378728
Graft-vs-Host Disease, Hematologic Neoplasms, Failure	Stem Cell Exhaustion	Allogeneic stem cell transplantation (SCT) is the most effective treatment option for many hematologic malignancies, but graft-versus-host disease (GVHD) remains a major cause of treatment failure.	23380341
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Central line-associated blood stream infections (CLABSI) commonly complicate the care of patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) after allogeneic stem cell transplantation (HCT).	23380342
Comorbidity	Stem Cell Exhaustion	The median age at transplantation was 52 years (range, 16 to 70); 34 had a high (>=3) HCT comorbidity index (HCT-CI); 34 received bone marrow (BM), 24 received peripheral stem cells (PSC), and 15 received umbilical cord blood cells (UCB).	23380342
Ischemia	Stem Cell Exhaustion	Bone marrow alterations and lower endothelial progenitor cell numbers in critical limb ischemia patients.	23383236
Endothelium	Stem Cell Exhaustion	Blood levels of markers for endothelial injury (sE-selectin, sICAM-1, sVCAM-1, and thrombomodulin), and progenitor cell mobilizing and inflammatory factors were assessed by conventional and multiplex ELISA.	23383236
CLU protein, human	Stem Cell Exhaustion	The results of this study suggest that inflammation-induced BM exhaustion and a disturbed progenitor cell mobilization response due to reduced levels and activity of MMP-9 in the BM and alterations in the SDF-1a/CXCR4 interaction contribute to the attenuated neovascularization in CLI patients.	23383236
Pathologic Neovascularization, CLU protein, human	Stem Cell Exhaustion	We hypothesize that reduced levels and function of circulating progenitor cells and alterations in the BM contribute to impaired neovascularization in CLI.	23383236
Neoplasms	Stem Cell Exhaustion	In the latter, tumor cells are quite similar to enterochromaffin granule containing crypt cells, which are regarded as their progenitor cells.	23383615
Multiple Myeloma	Stem Cell Exhaustion	Salvage autologous stem cell transplantation for multiple myeloma relapsing or progressing after up-front autologous transplantation.	23387937
Experimental Organism Malignant Hepatocholangiocellular Carcinoma	Stem Cell Exhaustion	Ten, 1, 32, and 11 cases were diagnosed as: combined hepatocellular-cholangiocarcinoma, classical type; combined hepatocellular-cholangiocarcinoma, stem cell features, typical subtype; combined hepatocellular-cholangiocarcinoma, stem cell features, intermediate cell subtype; and combined hepatocellular-cholangiocarcinoma, stem cell features, cholangiolocellular type, respectively.	23388123
Experimental Organism Malignant Hepatocholangiocellular Carcinoma	Stem Cell Exhaustion	The expression of CD133 and vimentin was observed only in combined hepatocellular-cholangiocarcinoma, stem cell features of intermediate cell subtype and cholangiolocellular subtype.	23388123
Experimental Organism Malignant Hepatocholangiocellular Carcinoma	Stem Cell Exhaustion	The expression of CD133, EpCAM, and vimentin was significantly high in combined hepatocellular-cholangiocarcinoma, subtypes with stem cell features, especially cholangiolocellular subtype.	23388123
Experimental Organism Malignant Hepatocholangiocellular Carcinoma	Stem Cell Exhaustion	Minor histologic patterns were significantly frequent in combined hepatocellular-cholangiocarcinoma, subtypes with stem cell features, compared with combined hepatocellular-cholangiocarcinoma, classical type.	23388123
Ischemia, Diabetic Foot	Stem Cell Exhaustion	Both autologous bone marrow mononuclear cell and peripheral blood progenitor cell therapies similarly improve ischaemia in patients with diabetic foot in comparison with control treatment.	23390092
Ischemia, Diabetic Foot	Stem Cell Exhaustion	The aim of our study was to compare the effect of bone marrow mononuclear cell and peripheral blood progenitor cell therapies in patients with diabetic foot disease and critical limb ischaemia unresponsive to revascularization with conservative therapy.	23390092
Kidney Failure, Proteinuria	Stem Cell Exhaustion	A 7-year-old boy with renal insufficiency and proteinuria after stem cell transplant for T-cell acute lymphoblastic leukemia.	23391318
Chronic Kidney Disease, CTCAE	Stem Cell Exhaustion	Chronic kidney disease is common in pediatric patients following hematopoietic stem cell transplant.	23391318
Graft-vs-Host Disease, Nephrotic Syndrome, Nuclear non-senile cataract	Stem Cell Exhaustion	Graft vs. host disease (GVHD) is a common sequela of hematopoietic stem cell transplant and has been associated with the nephrotic syndrome (NS).	23391318
Kidney Failure, Proteinuria	Stem Cell Exhaustion	Here we report a case of a pediatric patient who developed proteinuria and renal insufficiency after stem cell transplant.	23391318
leukemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	This study examined the course of neuropsychological functioning in patients with chronic myelogeous leukemia (n = 91) or myelodysplastic syndrome (n = 15) who underwent standard treatment for their disease or allogeneic hematopoietic stem cell transplantation (HSCT) at baseline, 12 months, and 18 months post-treatment.	23391504
Multiple Myeloma	Stem Cell Exhaustion	[Effect of bortezomib-based induction therapy on the peripheral blood stem cell harvest in multiple myeloma].	23391654
Multiple Myeloma	Stem Cell Exhaustion	A high dose of melphalan followed by autologous stem cell transplantation (ASCT) is considered as the standard therapy for multiple myeloma.	23391654
Lymphoma, Follicular	Stem Cell Exhaustion	Long-term clinical and molecular remissions in patients with follicular lymphoma following high-dose therapy and autologous stem cell transplantation.	23393125
Lymphoma, Follicular	Stem Cell Exhaustion	Long-term clinical and molecular remissions in patients with follicular lymphoma (FL) following high-dose therapy (HDT) and autologous stem cell transplantation (ASCT) have been evaluated in only a few studies.	23393125
Hypoxic-Ischemic Encephalopathy	Stem Cell Exhaustion	Environmental enrichment synergistically improves functional recovery by transplanted adipose stem cells in chronic hypoxic-ischemic brain injury.	23394350
Brain Injuries, Hawaii, Hypoxic-Ischemic Encephalopathy	Stem Cell Exhaustion	We investigated the effects of environmental enrichment (EE) on the function of transplanted adipose stem cells (ASCs) and the combined effect of EE and ASC transplantation on neurobehavioral function in an animal model of chronic hypoxic-ischemic (HI) brain injury.	23394350
Liver Failure, Acute	Stem Cell Exhaustion	Therapeutic potential of human induced pluripotent stem cell-derived mesenchymal stem cells in mice with lethal fulminant hepatic failure.	23394436
Liver Failure, Acute	Stem Cell Exhaustion	This study aims to produce MSCs from human induced pluripotent stem cells (hiPSCs) and to evaluate their therapeutic effects in a CCl4-induced mouse model of fulminant hepatic failure (FHF).	23394436
Adult Glioblastoma, Neoplasms	Stem Cell Exhaustion	MicroRNA-153 is tumor suppressive in glioblastoma stem cells.	23397238
Neoplasms, Glioblastoma	Stem Cell Exhaustion	Glioblastoma multiforme (GBM) is lethal brain tumor thought to arise from GBM stem cells (GBM-SCs).	23397238
Parkinson Disease	Stem Cell Exhaustion	Characterization of peripheral hematopoietic stem cells and monocytes in Parkinson's disease.	23401086
Nerve Degeneration	Stem Cell Exhaustion	This study investigated the impact of progressive neurodegeneration on the differentiation and development of hematopoietic stem cells in the peripheral blood of Parkinson's patients.	23401086
Parkinson Disease	Stem Cell Exhaustion	A colony-forming cell assay was established to study hematopoietic stem cells from venous blood of Parkinson's patients, and flow cytometry was used to analyze the expression of chemokine receptors on monocytes.	23401086
Chronic myeloproliferative disorder, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasia arising from the oncogenic break point cluster region/Abelson murine leukemia viral oncogene homolog 1 translocation in hematopoietic stem cells (HSCs), resulting in a leukemia stem cell (LSC).	23401488
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Cytotoxic T cells induce proliferation of chronic myeloid leukemia stem cells by secreting interferon-g.	23401488
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	In addition, IFN-g increased proliferation and colony formation of CD34(+) stem/progenitor cells from CML patients in vitro.	23401488
Comorbidity	Stem Cell Exhaustion	We thus retrospectively analyzed 14 patients with primary refractory or relapsed HL who were treated with brentuximab vedotin as single agent in a named patient program, who had not received prior high-dose chemotherapy (HDCT) and autologous stem cell transplant (ASCT) due to refractory disease (n = 9), comorbidity (n = 4) and unknown reasons (n = 1).	23402268
Specialty Type - cancer, Colorectal Carcinoma, Neoplasms	Stem Cell Exhaustion	CD44 standard isoform (CD44s) is a cancer stem cell marker in many tumors, and is one of the CD44 isoforms.CD44v6 has been reported to correlate with tumor progression and poor prognosis in colorectal cancer.	23404221
Neoplasms	Stem Cell Exhaustion	Blood was collected for pharmacokinetic analysis and measurements of circulating tumor cells and circulating endothelial (progenitor) cells (CE(P)Cs).	23404627
Childhood Breast Carcinoma	Stem Cell Exhaustion	Tetrathiomolybdate-associated copper depletion decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse.	23406736
PAFAH1B1 wt Allele, Decreased platelet count	Stem Cell Exhaustion	This research shows a hypoplastic thrombocytopenia that platelets from MDS patients possess an impaired ability to be stimulated and more apoptosis markers than those from healthy controls, indicating that MDS is a stem cell disorder, and then, both number and function of progeny cells, might be affected.	23407717
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Patients with myelodysplastic syndromes (MDS) have a defect in the differentiation of bone marrow multipotent progenitor cells.	23407717
Kidney Failure, Acute	Stem Cell Exhaustion	In acute kidney injury, indoxyl sulfate impairs human endothelial progenitor cells: modulation by statin.	23408148
Kidney Failure, Acute, Ischemia of kidney	Stem Cell Exhaustion	Renal ischemia rapidly mobilizes endothelial progenitor cells (EPCs), which provides renoprotection in acute kidney injury (AKI).	23408148
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Recent studies indicate the presence of pre-existing BCR-ABL mutations in a higher percentage of CML patients when CD34+ stem/progenitor cells are investigated using sensitive techniques, and these mutations are associated with imatinib resistance and disease progression.	23409026
Acute Coronary Syndrome	Stem Cell Exhaustion	In vitro characterization of circulating endothelial progenitor cells isolated from patients with acute coronary syndrome.	23409178
Cardiovascular Diseases	Stem Cell Exhaustion	The current understanding of the functional characteristics of circulating endothelial progenitor cells (EPC) is limited, especially in patients affected by cardiovascular diseases.	23409178
Toxic effect, LIPC gene	Stem Cell Exhaustion	This retrospective study evaluated the efficacy and toxicity of bendamustine in 28 patients with refractory HL or relapsed HL after autologous stem cell transplant (ASCT) used as part of a compassionate use program.	23410099
Cardiomyopathies	Stem Cell Exhaustion	Studies in animals have proposed the cardiac progenitor cells (CPCs) as the cellular target responsible for DOXO-induced cardiomyopathy but the relevance of these observations to clinical settings is unknown.	23411815
Specialty Type - cancer	Stem Cell Exhaustion	This cross sectional study included 141 cancer patients who underwent chemotherapy or hematopoietic progenitor cell transplantation and received platelet transfusions at The University of Texas M.D.	23416822
Neoplasms	Stem Cell Exhaustion	Tumor cells that express CD44 and CD24 exhibit a stem-cell-like behavior.	23419168
Communicable Diseases	Stem Cell Exhaustion	Human cytomegalovirus (HCMV) infection causes significant morbidity and mortality after hematopoietic stem cell transplantation (HSCT).	23424600
Nasopharyngeal carcinoma	Stem Cell Exhaustion	Embryonic stem cells markers SOX2, OCT4 and Nanog expression and their correlations with epithelial-mesenchymal transition in nasopharyngeal carcinoma.	23424657
Malignant Neoplasms	Stem Cell Exhaustion	Expression of embryonic stem cells (ESCs) markers (SOX2, OCT4, Nanog and Nestin) is crucial for progression of various human malignancies.	23424657
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Outcome of patients with transformed indolent non-Hodgkin lymphoma referred for autologous stem-cell transplantation.	23425946
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	The proportion of potentially eligible patients with transformed indolent non-Hodgkin lymphoma who undergo autologous stem-cell transplantation (ASCT) is unknown.	23425946
Class Cestoda	Stem Cell Exhaustion	Although adult pluripotent stem cells, called neoblasts, drive long-term homeostatic tissue maintenance in long-lived free-living flatworms (for example, planarians), and neoblast-like cells have been described in some parasitic tapeworms, little is known about whether similar cell types exist in any trematode species.	23426263
Aplastic Anemia	Stem Cell Exhaustion	Effect of kidney-reinforcing, blood-activating and stasis-removing recipes on adhesion molecule expression of bone marrow mesenchymal stem cells from chronic aplastic anemia patients.	23427395
Aplastic Anemia	Stem Cell Exhaustion	To explore the effect of kidney-reinforcing, blood-activating and stasis-removing recipes on adhesion molecule expression of bone marrow mesenchymal stem cells (MSCs) from patients with chronic aplastic anemia (CAA).	23427395
Cerebral Atherosclerosis	Stem Cell Exhaustion	Decreased levels of angiogenic growth factors in intracranial atherosclerotic disease despite severity-related increase in endothelial progenitor cell counts.	23429001
Heart failure, Ischemic cardiomyopathy	Stem Cell Exhaustion	These data highlight the importance of defining the molecular mechanisms of stem cell-based tissue repair and suggest that overexpression of stromal cell-derived factor-1 via gene therapy is a strategy for improving heart failure symptoms in patients with ischemic cardiomyopathy.	23429605
Hematologic Neoplasms, Neoplasms, Aplastic Anemia	Stem Cell Exhaustion	The underlying disease was hematological malignancy and disorders in 76.3 % (29 cases), solid tumors in 15.8 % (six cases), aplastic anemia in 7.9 % (three cases), while 18.4 % (seven cases) were hematopoietic stem cell transplantation (HSCT) recipients.	23430671
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Impact of allogeneic haematopoietic stem cell transplantation in patients with abnl(17p) acute myeloid leukaemia.	23432431
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The role of allogeneic stem cell transplantation (HSCT) as compared to chemotherapy in acute myeloid leukaemia (AML) patients with abnormalities of chromosome 17p [abnl(17p)] has not yet been defined.	23432431
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	The purpose of this analysis was to provide 6-year follow-up of the CLL3X trial, which studied reduced-intensity allogeneic hematopoietic stem cell transplantation (HSCT) in patients with poor-risk chronic lymphocytic leukemia (CLL), and to investigate the effect of TP53, SF3B1, and NOTCH1 mutations on HSCT outcome.	23435461
Graft-vs-Host Disease, Allogeneic Hematopoietic Stem Cell Transplantation	Stem Cell Exhaustion	Diagnosis and evaluation of intestinal graft-versus-host disease after allogeneic hematopoietic stem cell transplantation following reduced-intensity and myeloablative conditioning regimens.	23435651
Graft-vs-Host Disease	Stem Cell Exhaustion	Colonoscopic evaluation of mucosal tissues after allogeneic hematopoietic stem cell transplantation (HSCT) is very useful in evaluating pathogenesis and diagnosis of intestinal graft-versus-host disease (GVHD).	23435651
Hepatitis B, Multiple Myeloma	Stem Cell Exhaustion	Hepatitis B virus infection status is an independent risk factor for multiple myeloma patients after autologous hematopoietic stem cell transplantation.	23436046
Morular Metaplasia of the Endometrium, Hepatitis B, Multiple Myeloma, Communicable Diseases	Stem Cell Exhaustion	The purposes of this study were to evaluate the infection by hepatitis B virus (HBV) and its impact on survival and to provide a clinical reference for monitoring and treating HBV during and after autologous hematopoietic stem cell transplantation (ASCT) in patients with multiple myeloma (MM).	23436046
Nephrosis, Immune System Diseases	Stem Cell Exhaustion	The patient's course supports suggestions that immunological dysfunction in nephrosis is associated with abnormality of immature, relatively unclassified T cells (CD34(+)) representing hematopoietic stem cells, as opposed to mature T cells (CD34(-)).	23436177
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Patients with higher-risk disease have a higher risk of progression to AML and are treated with hypomethylating agents (azacitidine or decitabine) and allogeneic stem cell transplantation if appropriate.	23436197
Pancreatic carcinoma	Stem Cell Exhaustion	LGR5 and Nanog identify stem cell signature of pancreas beta cells which initiate pancreatic cancer.	23438436
Respiratory Syncytial Virus Infections	Stem Cell Exhaustion	We compared HRSV infections among Haematopoietic Stem Cell Transplant program (HSCT) patients and children using direct immunofluorescence (DFA), point-of-care RSV Bio Easy(r) and a polymerase chain reaction (PCR) assay.	23440127
Inflammation	Stem Cell Exhaustion	Pathological changes of the anatomical structure and markers of the limbal stem cell niche due to inflammation.	23441125
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Hematopoietic stem cell and solid organ transplant recipients diagnosed with biopsy-confirmed posttransplant lymphoproliferative disorder (PTLD) at our institution from 1989 to 2010 were identified.	23442063
Multiple Myeloma	Stem Cell Exhaustion	Antibody titers >= 1 : 40 persisted for 50% of responding patients at 1 yr. Seroconversion was observed in 69% of 14 patients who had undergone hematopoietic stem cell transplantation and in all (9/9) patients with myeloma (five with ongoing treatment including high-dose corticosteroids).	23444982
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	CD133 was recently reported to be a cancer stem cell marker and a prognostic marker for several tumors.	23448401
Pancreatic carcinoma	Stem Cell Exhaustion	We evaluated AGS-1C4D4, a fully human monoclonal antibody to prostate stem cell antigen (PSCA), with gemcitabine in a randomized, phase II study of metastatic pancreatic cancer.	23448807
Aplastic Anemia	Stem Cell Exhaustion	In vivo T-cell depletion with alemtuzumab in allogeneic hematopoietic stem cell transplantation: Combined results of two studies on aplastic anemia and HLA-mismatched haploidentical transplantation.	23450467
Aplastic Anemia	Stem Cell Exhaustion	We evaluated the efficacy of in vivo T-cell depletion with alemtuzumab in two prospective studies according to the International Conference on Harmonisation (ICH)-Good Clinical Practice (ICH-GCP) guidelines; one was for patients with aplastic anemia (AA study) and the other was for patients who were undergoing hematopoietic stem cell transplantation (HSCT) from a 2- or 3-antigen-mismatched haploidentical donor (MM study).	23450467
methyldopa	Stem Cell Exhaustion	Recently a clinical trial was approved by FDA to investigate the safety and efficacy of the human embryonic stem cell-derived retinal pigment epithelium (RPE) transplantation in sub-retinal space of patients with dry AMD These studies suggest that stem cell research may provide both insight regarding disease development and progression, as well as direction for therapeutic innovation for the millions of patients afflicted with AMD.	23452406
Multiple Myeloma	Stem Cell Exhaustion	A phase 1 study of bendamustine and melphalan conditioning for autologous stem cell transplantation in multiple myeloma.	23454184
Toxic effect, Multiple Myeloma	Stem Cell Exhaustion	We hypothesized that adding bendamustine to autologous stem cell transplant conditioning in myeloma would enhance response without significant additional toxicity.	23454184
Multiple Myeloma	Stem Cell Exhaustion	Six patients (24%) with pre-existing high-risk disease died from progressive myeloma during study follow-up, all at or beyond 100 days after autologous stem cell transplant.	23454184
Toxic effect, Multiple Myeloma	Stem Cell Exhaustion	Bendamustine up to a dose of 225 mg/m(2) added to autologous stem cell transplantation conditioning with high-dose melphalan in patients with multiple myeloma did not exacerbate expected toxicities.	23454184
Pulmonary Infiltrate	Stem Cell Exhaustion	Utility of flexible bronchoscopy in the evaluation of pulmonary infiltrates in the hematopoietic stem cell transplant population -- a single center fourteen year experience.	23455477
Primary central nervous system lymphoma	Stem Cell Exhaustion	Other chemotherapeutics and novel treatments, such as autologous stem cell transplantation, are being studied for potential use in PCNSL.	23456261
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Impact of cardiac stem cell sheet transplantation on myocardial infarction.	23459789
Hepatic Encephalopathy	Stem Cell Exhaustion	Tacrolimus-associated posterior reversible encephalopathy syndrome in hematopoietic allogeneic stem cell transplantation.	23460378
Encephalopathy, CTCAE 5.0, Posterior reversible encephalopathy syndrome	Stem Cell Exhaustion	Tacrolimus-associated posterior reversible encephalopathy syndrome (PRES) is a potential complication of allogeneic stem cell transplant (SCT).	23460378
Multiple Myeloma	Stem Cell Exhaustion	Long-term outcome after allogeneic stem-cell transplantation with reduced-intensity conditioning in patients with multiple myeloma.	23460414
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	A total of 53 patients with multiple myeloma (MM) who received allogeneic hematopoietic stem-cell transplantation (Allo-SCT) between January 2000 and January 2007 were identified.	23460414
Neoplasms	Stem Cell Exhaustion	Tumour cells were consistently devoid of efflux properties regardless of their genetic background, tumour ploidy or stem cell associated marker expression.	23460667
Communicable Diseases	Stem Cell Exhaustion	Human herpesvirus type 6 DNAemia and infection following allogeneic stem cell transplantation with a focus on long-term outcome.	23461659
Communicable Diseases	Stem Cell Exhaustion	Cases of human herpesvirus type 6 (HHV-6) infection and disease were retrospectively analysed in a cohort of 97 allogeneic haematopoietic stem cell transplantation (allo-SCT) patients in Gothenburg, Sweden (1997-2001).	23461659
Graft-vs-Host Disease	Stem Cell Exhaustion	Low-dose alemtuzumab vs. standard policy for prevention of graft-versus-host disease in unrelated and related allogeneic stem cell transplantation-a matched pair analysis.	23463451
Hematologic Neoplasms, Neoplasms	Stem Cell Exhaustion	Fifty-one percent had solid tumors, 32% had hematological malignancies, and 17% underwent stem cell transplantation.	23464712
Chronic heart failure	Stem Cell Exhaustion	Expression of miR-126 and miR-508-5p in endothelial progenitor cells is associated with the prognosis of chronic heart failure patients.	23465244
physiopathological, Coronary Arteriosclerosis	Stem Cell Exhaustion	MicroRNA (miRNA) expression profiles in endothelial progenitor cells (EPCs) contribute to EPC dysfunction in patients suffering from coronary artery disease.	23465244
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Donor cell leukemia (DCL) is a rare but severe complication after allogeneic stem cell transplantation.	23465275
Triple-Negative Breast Cancer Finding, Specialty Type - cancer	Stem Cell Exhaustion	In models of triple-negative breast cancer (TNBC), it has recently been shown that the epidermal growth factor receptor (EGFR) pathway is up-regulated in the aldehyde dehydrogenase 1 (ALDH1)-positive cancer stem cell fraction.	23465277
Brain Injuries	Stem Cell Exhaustion	Ischemic brain injury: a consortium analysis of key factors involved in mesenchymal stem cell-mediated inflammatory reduction.	23466243
PAFAH1B1 wt Allele, Bone Marrow Diseases, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is a group of progressive,clonal, neoplastic bone marrow disorders characterized by hematopoietic stem cell dysregulation and abnormalities in the immune system.	23469196
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	The different immunoregulatory functions on dendritic cells between mesenchymal stem cells derived from bone marrow of patients with low-risk or high-risk myelodysplastic syndromes.	23469196
Myopathy	Stem Cell Exhaustion	Because the symptoms of myopathy gradually improved and disappeared completely, the patient was able to undergo one course of intensive chemotherapy and allogeneic stem cell transplantation from an HLA-matched sibling donor, 8 months after admission (7 months after the re-administration of IM).	23470829
Leukemia, Myelocytic, Acute, Decreased platelet count	Stem Cell Exhaustion	[Emergence of donor-derived anti-HLA antibody and subsequent transfusion-refractory thrombocytopenia after allogeneic hematopoietic stem cell transplantation from an HLA-matched sibling donor in a patient with acute myeloid leukemia].	23470830
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 45-year-old woman with acute myelogenous leukemia developed platelet transfusion refractoriness (PTR) after the engraftment of an allogeneic peripheral blood stem cell transplantation (PBSCT) from her multiparous sister, which was attributed to HLA antibodies that could not be detected in the patient's serum before transplantation.	23470830
Ischemia	Stem Cell Exhaustion	Attenuation of hind-limb ischemia in mice with endothelial-like cells derived from different sources of human stem cells.	23472116
Ischemia	Stem Cell Exhaustion	We differentiated functional EC from human bone marrow mononuclear cells (BM-EC), human embryonic stem cells (hESC-EC) and human induced pluripotent stem cells (hiPSC-EC), and compared their in-vitro tube formation, migration and cytokine expression profiles, and in-vivo capacity to attenuate hind-limb ischemia in mice.	23472116
Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Only one-quarter to one-third of patients with relapsed/refractory aggressive non-Hodgkin lymphoma (r/r-aNHL) treated with common salvage chemotherapy regimens and autologous stem cell transplant (ASCT) achieve 5-year progression-free survival (PFS).	23472969
leukemia, Leukemia, Myelocytic, Acute, Immature Myeloid Cell	Stem Cell Exhaustion	Clustered immature myeloid precursors in intertrabecular region during remission evolve from leukemia stem cell near endosteum and contribute to disease relapse in acute myeloid leukemia.	23474071
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Most acute myeloid leukemia (AML) cannot be cured because leukemia stem cells (LSC) will contribute to eventual relapse.	23474071
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Long-term follow up of patients proceeding to transplant using plerixafor mobilized stem cells and incidence of secondary myelodysplastic syndrome/AML.	23474805
Leukemia, T-Cell	Stem Cell Exhaustion	Potential contribution of a novel Tax epitope-specific CD4+ T cells to graft-versus-Tax effect in adult T cell leukemia patients after allogeneic hematopoietic stem cell transplantation.	23475215
TCL4 gene, TRPV6 wt Allele	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for adult T cell leukemia/lymphoma (ATL) caused by human T cell leukemia virus type 1 (HTLV-1).	23475215
Specialty Type - cancer	Stem Cell Exhaustion	Previous reports suggest that a CD133-positive subpopulation of multipotent cells with extensive proliferative and self-renewal characteristics has biological features of a cancer stem cell.	23479121
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Selective killing of candidate AML stem cells by antibody targeting of IL1RAP.	23479569
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	IL1RAP, a co-receptor for interleukin (IL)-1 and IL-33 receptors, was previously found to be highly upregulated on candidate chronic myeloid leukemia stem cells, allowing for leukemia-selective killing using IL1RAP-targeting antibodies.	23479569
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	With the aim to target AML stem cells, an anti-IL1RAP monoclonal antibody was generated followed by isotype switching for improved antibody-dependent, cell-mediated cytotoxicity activity.	23479569
Graft-vs-Host Disease	Stem Cell Exhaustion	Minor histocompatibility antigens as determinants for graft-versus-host disease after allogeneic haematopoietic stem cell transplantation.	23480177
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukemia (AML) is a deadly disease characterized by the clonal expansion and accumulation of hematopoietic stem cells arrested at various stages of development.	23481040
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	Lack of prognostic significance of neuroendocrine differentiation and stem cell antigen co-expression in resected early-stage non-small cell lung cancer.	23482770
Carcinoid Tumor, Carcinoma of lung	Stem Cell Exhaustion	Neuroendocrine (NE) carcinomas of the lung exhibit expression of various stem cell antigens, and except for carcinoid tumours, carry a poor prognosis.	23482770
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	Despite the fact that 10%-30% of all non-small cell lung carcinomas (NSCLC) which are not classified as NE carcinomas also show expression of NE markers, data on their prognostic significance are conflicting and analyses of the expression and relevance of stem cell antigens in this subgroup are lacking.	23482770
Non-Small Cell Lung Carcinoma, Childhood Breast Carcinoma	Stem Cell Exhaustion	Moreover, the subgroup of NSCLC with NE differentiation (ND) were assessed for the expression and prognostic significance of the stem cell antigens CD117, CD133 and breast cancer resistance protein-1 (ABCG2).	23482770
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	This study indicates that neither ND, nor co-expression of the stem cell antigens CD117, CD133 or ABCG2, have a prognostic significance in resected early-stage NSCLC.	23482770
Multiple Myeloma	Stem Cell Exhaustion	Autologous/reduced-intensity allogeneic stem cell transplantation vs autologous transplantation in multiple myeloma: long-term results of the EBMT-NMAM2000 study.	23482933
Leukemia, Mast-Cell, Mastocytosis, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A case of systemic mastocytosis associated with acute myeloid leukemia terminating as aleukemic mast cell leukemia after allogeneic hematopoietic stem cell transplantation.	23483057
Leukemia, Mast-Cell, Aplastic Anemia	Stem Cell Exhaustion	After allogeneic hematopoietic stem cell transplantation (HSCT), leukemic myeloblasts were not observed; however, neoplastic metachromatic blasts strikingly proliferated during the state of bone marrow aplasia, and finally, aleukemic mast cell leukemia developed.	23483057
Encephalomyelitis	Stem Cell Exhaustion	We describe a rare case of fatal mumps encephalomyelitis occurring in 19-year old male following matched unrelated donor peripheral blood haematopoietic stem cell transplantation (HSCT).	23485346
Non-Neoplastic Hematologic and Lymphocytic Disorder	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation is the only potentially curative therapeutic option for many malignant and nonmalignant hematologic disorders.	23491865
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	The patient, presenting an high risk myelodysplastic syndrome (MDS), underwent an allogeneic peripheral stem cells transplantation.	23491865
Nerve Degeneration	Stem Cell Exhaustion	let-7 miRNAs regulate stem cell differentiation and T cell activation, activate Toll-like receptor 7, and are linked to neurodegeneration.	23494648
Hematologic Neoplasms	Stem Cell Exhaustion	The use of allogeneic haematopoietic stem cell transplantation (Allo-HSCT) is a standard treatment option for many patients with haematological malignancies.	23496350
Hepatitis B	Stem Cell Exhaustion	The more profound immunosuppression in recipients of hematopoietic stem cell transplantations (HCT) can lead to more complicated hepatitis B virus (HBV)-related events.	23498831
Hepatitis B	Stem Cell Exhaustion	However the donor had hepatitis B surface antigen (HbsAg) positivity, and collected stem cells were positive for HBV DNA (1 x 10(4) copies/mL).	23498831
Specialty Type - cancer, Cytogenetic Complete Response	Stem Cell Exhaustion	In CRC specimens, expression of CD133, a cancer stem cell marker, was significantly correlated with gankyrin expression.	23508981
Cytogenetic Complete Response	Stem Cell Exhaustion	In CRC development, gankyrin would control stem cell behavior by regulating the expression of stemness factors.	23508981
Crushing injury	Stem Cell Exhaustion	They also differentiated into all three germ layer lineages both in vitro and in vivo, produced cartilage more efficiently compared to bone marrow stem cells and, importantly, restored erectile function in a cavernous nerve crush injury rat model.	23509942
Multiple Myeloma	Stem Cell Exhaustion	Comparable outcome of stem cell transplant versus bortezomib-based consolidation in myeloma patients after major response to induction.	23510553
Multiple Myeloma	Stem Cell Exhaustion	High-dose therapy with autologous stem cell transplant (ASCT) has been established as standard treatment for eligible patients with myeloma.	23510553
Leishmania donovani	Stem Cell Exhaustion	Stem cell transplant was planned due to repeated reactivations of disease, but his pretransplant bone marrow revealed an unexpected protozoan-Leishmania donovani.	23511497
Cessation of life	Stem Cell Exhaustion	Increase of suicide and accidental death after hematopoietic stem cell transplantation: a cohort study on behalf of the Late Effects Working Party of the European Group for Blood and Marrow Transplantation (EBMT).	23512286
Encephalitis, Allogeneic Hematopoietic Stem Cell Transplantation, Herpes	Stem Cell Exhaustion	Human herpes 6 virus encephalitis complicating allogeneic hematopoietic stem cell transplantation.	23516318
Encephalitis	Stem Cell Exhaustion	To describe the presentation and management of encephalitis due to human herpes 6 virus (HHV-6) in patients who underwent allogeneic hematopoietic stem cell transplant (alloHSCT), via retrospective chart review.	23516318
Childhood Breast Carcinoma	Stem Cell Exhaustion	Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance.	23519090
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal hematopoietic stem cell diseases.	23519573
Pulmonary Emphysema	Stem Cell Exhaustion	Due to his severe emphysema, the patient was considered ineligible for stem cell transplantation, and azacitidine therapy was initiated.	23519573
Hematological Disease	Stem Cell Exhaustion	Comparison of outcomes after two standards-of-care reduced-intensity conditioning regimens and two different graft sources for allogeneic stem cell transplantation in adults with hematologic diseases: a single-center analysis.	23523970
Toxic effect	Stem Cell Exhaustion	Recent advances in allogeneic stem cell transplantation (allo-HSCT) have included the advent of reduced-intensity conditioning (RIC) regimens to decrease the toxicity of myeloablative allo-SCT and the use of double umbilical cord blood (dUCB) units as a graft source in adults lacking a suitable donor.	23523970
Allogeneic Hematopoietic Stem Cell Transplantation, Acute GVH disease	Stem Cell Exhaustion	Salivary proteomic analysis and acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.	23529013
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GVHD) is the major life-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT), developing in 35%-70% of all allo-HSCT recipients despite immunosuppressive prophylaxis.	23529013
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	CD20-targeted T cells after stem cell transplantation for high risk and refractory non-Hodgkin's lymphoma.	23529012
melanoma	Stem Cell Exhaustion	In vitro expansion and characterization of corneal stem cells isolated from an eye with malignant melanoma.	23529306
Malignant Neoplasms	Stem Cell Exhaustion	Donor age (72 years) and the presence of a malignant tumor close to limbal stem niche could have had an impact on the proliferation rate and the characteristics of the corneal stem cells.	23529306
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Impact of pre-transplant marrow blasts on survival of allogeneic stem cell transplantation in adult acute myeloid leukemia.	23529846
Mumps	Stem Cell Exhaustion	A five-year-old Canadian-born boy with a history of a hematopoetic stem cell transplant three years previously received live attenuated measles, mumps, and rubella (MMR) vaccine.	23531102
Neoplasms	Stem Cell Exhaustion	Autologous stem cell transplantation and cyberknife therapy resulted in mixed tumor response, with incidental note made of prominent areas of cortical FDG avidity in the right kidney.	23531731
Aggressive Non-Hodgkin Lymphoma, Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	High-dose chemotherapy (HDT) followed by autologous stem cell transplantation (ASCT) is considered standard in the treatment of patients with relapsed or refractory aggressive peripheral T cell lymphoma (PTCL).	23532626
Glioblastoma Multiforme Pathway, Adult Glioblastoma, Neoplasms	Stem Cell Exhaustion	Stem cell-like properties of glioma initiating cells (GiCs) fuel glioblastoma (GBM) development by providing the different cell types that comprise the tumor.	23533157
Multiple Myeloma	Stem Cell Exhaustion	Living with advanced but stable multiple myeloma: a study of the symptom burden and cumulative effects of disease and intensive (hematopoietic stem cell transplant-based) treatment on health-related quality of life.	23535325
Experimental Organism Basal Cell Carcinoma, Malignant Neoplasms	Stem Cell Exhaustion	The basal cell carcinoma is a malignant tumor which originates from the epidermal stem cells.	23535947
Malignant neoplasm of ovary	Stem Cell Exhaustion	Stem cell-like gene expression in ovarian cancer predicts type II subtype and prognosis.	23536770
Malignant neoplasm of ovary	Stem Cell Exhaustion	The purpose of this study was the genomic identification and characterization of a subtype of ovarian cancer that has stem cell-like gene expression.	23536770
Malignant neoplasm of ovary, Neoplasms	Stem Cell Exhaustion	The stem cell-like signature was prognostic within high-stage serous ovarian cancer, classifying a small subset of high-stage tumors with better prognosis, in the differentiated subtype.	23536770
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells are believed to have properties that allow them to survive therapy and may drive recurrent tumor growth.	23536770
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells or cancer-initiating cells are a rare cell population and difficult to isolate experimentally.	23536770
Malignant neoplasm of ovary, Neoplasms	Stem Cell Exhaustion	Genes that are expressed by stem cells may characterize a subset of less differentiated tumors and aid in prognostic classification of ovarian cancer.	23536770
Specialty Type - cancer, ovarian neoplasm	Stem Cell Exhaustion	Using human and mouse gene signatures of embryonic, adult, or cancer stem cells, we performed an unsupervised bipartition class discovery on expression profiles from 145 serous ovarian tumors to identify a stem-like and more differentiated subgroup.	23536770
Specialty Type - cancer	Stem Cell Exhaustion	Patients (N = 627) in stem cell transplant (SCT) and medical (MED) or radiation (RAD) oncology at two comprehensive cancer centers, enrolled in the Electronic Self-Report Assessment-Cancer study and completed the QLQ-C30 at T1 and T2.	23537330
Specialty Type - cancer, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Cancer stem cells (CSCs) are notorious for their capacity of tumor progression, metastasis or resistance to chemo-radiotherapy.	23537343
Glioblastoma	Stem Cell Exhaustion	Neural progenitor cells in the subventricular zone (SVZ) have a controversial role in glioblastoma multiforme (GBM) as potential tumor-initiating cells.	23540348
Primary immune deficiency disorder	Stem Cell Exhaustion	Pathway and network analysis of the differentially expressed proteins by Ingenuity Pathway Analysis revealed vital canonical pathways involving acute phase response signaling, the complement system, LXR/RXR activation, hematopoiesis from pluripotent stem cells, and primary immunodeficiency signaling.	23541716
FLT3 Internal Tandem Duplication, Nephroblastoma, Leukemia, Myelocytic, Acute, Cytogenetically normal acute myeloid leukemia	Stem Cell Exhaustion	Using real-time quantitative PCR, we monitored Wilms tumor gene 1 (WT1) expression from diagnosis to hematopoietic stem cell transplantation (HSCT) in adult patients with cytogenetically normal acute myelogenous leukemia (CN-AML) and FLT3-ITD and NPM1 mutations.	23542687
Malignant tumor of colon	Stem Cell Exhaustion	Prognostic value of changes in the expression of stem cell markers in the peripheral blood of patients with colon cancer.	23545848
Colorectal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Samples of EDTA blood were collected from metastatic colorectal cancer patients, and circulating cancer stem cells were isolated for the analysis of the expression of stem cell markers using RT-PCR.	23545848
Specialty Type - cancer, Secondary Neoplasm, Carcinogenesis	Stem Cell Exhaustion	Cancer stem cells play an important role in carcinogenesis and resistance to treatment and may lead to metastasis.	23545848
Prostate carcinoma	Stem Cell Exhaustion	Hypoxia of PC-3 prostate cancer cells enhances migration and vasculogenesis in vitro of bone marrow-derived endothelial progenitor cells by secretion of cytokines.	23546641
Lymphoma, Follicular	Stem Cell Exhaustion	The objective of this randomized trial was to assess the efficacy and safety of rituximab as in vivo purging before transplantation and as maintenance treatment immediately after high-dose chemotherapy and autologous stem-cell transplantation (HDC-ASCT) in patients with relapsed follicular lymphoma (FL).	23547078
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Dasatinib maintenance therapy after allogeneic hematopoietic stem cell transplantation for an isolated central nervous system blast crisis in chronic myelogenous leukemia.	23548721
Anemia, Leukocytosis	Stem Cell Exhaustion	Although offered to her because of severe anemia and leukocytosis, the patient did not consent to allogeneic hematopoietic stem cell transplantation.	23548970
Specialty Type - cancer	Stem Cell Exhaustion	The restricted cataloging of cancer genomes is quite unlikely to achieve the task of curing cancer, unless it is integrated into metabolic networks that respond to and influence the constantly evolving cancer stem cell (CSC) cellular states.	23549172
Specialty Type - cancer	Stem Cell Exhaustion	The Warburg effect version 2.0: metabolic reprogramming of cancer stem cells.	23549172
Bronchiolitis Obliterans, Allogeneic Hematopoietic Stem Cell Transplantation	Stem Cell Exhaustion	A case-control study of bronchiolitis obliterans syndrome following allogeneic hematopoietic stem cell transplantation.	23551210
Bronchiolitis Obliterans, Bosnian language	Stem Cell Exhaustion	Bronchiolitis obliterans syndrome (BOS) is a significant complication after allogeneic hematopoietic stem cell transplantation (HSCT).	23551210
Extrapulmonary Small Cell Carcinoma, Squamous cell carcinoma of esophagus, Adenocarcinoma Of Esophagus	Stem Cell Exhaustion	Five potential new molecular targets in esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC) were investigated for their expression characteristics: vascular endothelial growth factor receptor (VEGFR)-3, human epidermal growth factor receptor-2, stem cell growth factor receptor, tissue inhibitors of metalloproteinase (TIMP)-4 and TIMP-3.	23551625
Extrapulmonary Small Cell Carcinoma, Neoplasms	Stem Cell Exhaustion	For TIMP-4, TIMP-3 and stem cell growth factor receptor, trends to higher expression in tumor tissue were also found in EAC and ESCC that had received neoadjuvant treatment.	23551625
Metapneumovirus	Stem Cell Exhaustion	Fatal human metapneumovirus infection following allogeneic hematopoietic stem cell transplantation.	23551689
Communicable Diseases, Chronic graft-versus-host disease, Respiratory Tract Diseases, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Here, we report the occurrence of fatal lower respiratory tract disease associated with human metapneumovirus (HMPV) infection in a 10-year-old girl with chronic graft-versus-host disease following allogeneic hematopoietic stem cell transplantation (HSCT) for secondary chronic myeloid leukemia.	23551689
Conjunctival scar	Stem Cell Exhaustion	Forty eyes of 39 patients with severe limbal stem cell deficiency and conjunctival scarring or symblepharon underwent transplantation of autologous cocultivated epithelium on human amniotic membrane.	23552358
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Abnormal proliferation and differentiation of hematopoietic stem/progenitor cells, which reflect the malignant nature of clonal cells in myelodysplastic syndromes (MDS), can be detected by flow cytometry (FCM) and potentially applied to assist diagnosis and evaluate prognosis in MDS.	23554290
Microvascular Angina	Stem Cell Exhaustion	Effect of exercise on circulating endothelial progenitor cells in microvascular angina.	23558828
Microvascular Angina, Endothelial dysfunction, doxorubicin/mitomycin/vinblastine protocol	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPCs) might limit endothelial dysfunction in patients with microvascular angina (MVA).	23558828
Communicable Diseases	Stem Cell Exhaustion	We have used humanized mice, in which human immune cells differentiate de novo from transplanted cord blood progenitor cells, to study the human immune responses to infection with Mycobacterium bovis bacillus Calmette-Guerin and Mycobacterium tuberculosis.	23559373
Cell Proliferation	Stem Cell Exhaustion	We previously reported that importin 13 (IPO13), a member of the importin-b family of nuclear import proteins, regulates nuclear import of the glucocorticoid receptor in airway epithelial cells, IPO13 serves as a potential marker for corneal epithelial progenitor cells, and IPO13 is associated with corneal cell proliferation.	23559854
Coronary Arteriosclerosis	Stem Cell Exhaustion	The objective of this study was to assess the effect of high-dose atorvastatin treatment on endothelial progenitor cell (EPC) recruitment and angiographic and clinical outcome in coronary artery disease (CAD) patients treated with the Genous EPC-capturing stent.	23561893
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Efficacy and safety of autologous bone marrow-derived stem cell transplantation in patients with type 2 diabetes mellitus: a randomized placebo-controlled study.	23561959
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Busulfan dose intensity and outcomes in reduced-intensity allogeneic peripheral blood stem cell transplantation for myelodysplastic syndrome or acute myeloid leukemia.	23562738
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	busulfan dosing (total dose 3.2 mg/kg versus 6.4 mg/kg) in RIC regimens that combined fludarabine and busulfan on outcomes in patients who were undergoing hematopoietic stem cell transplantation (HSCT) for myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML).	23562738
Peripheral Stem Cell Transplantation, PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A total of 217 consecutive patients with MDS or AML underwent first busulfan and fludarabine RIC peripheral blood stem cell transplantation from well-matched related or unrelated donors at our institutions between 2004 and 2009.	23562738
Peripheral Stem Cell Transplantation, PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	For the majority of patients with MDS or AML undergoing busulfan and fludarabine RIC peripheral blood stem cell transplantation, however, the dose of busulfan (3.2 mg/kg versus 6.4 mg/kg) is not associated with significant differences in overall outcomes.	23562738
Specialty Type - cancer, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology	Stem Cell Exhaustion	SDF-1-CXCR4 axis: cell trafficking in the cancer stem cell niche of head and neck squamous cell carcinoma.	23563306
Specialty Type - cancer	Stem Cell Exhaustion	The SDF-1-CXCR4 axis is postulated to be a crucial key pathway in the interaction between (cancer) stem cells and their surrounding supportive cells in the cancer stem cell niche.	23563306
Specialty Type - cancer	Stem Cell Exhaustion	We evaluated the expression of CD44 as a cancer stem cell marker and of CXCR4 in human HNSCC tissue samples.	23563306
Neoplasms	Stem Cell Exhaustion	We showed that CD44, as a stem cell marker in HNSCC, is located mainly at the borderline of HNSCC tumor nests with the surrounding cells.	23563306
Specialty Type - cancer	Stem Cell Exhaustion	We collected evidence that SDF-1-CXCR4 interaction may be a crucial pathway in cell trafficking in the cancer stem cell niche of HNSCC, while SDF-1 was not detected in the peripheral blood of HNSCC patients.	23563306
Specialty Type - cancer	Stem Cell Exhaustion	The SDF-1-CXCR4 axis may play an important role in the cancer stem cell theory of HNSCC.	23563306
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Granulocyte-colony stimulating factors (G-CSFs) enhance bone marrow (BM) recovery after autologous stem cell transplant (ASCT) in patients with lymphoma and myeloma.	23566160
Toxic effect	Stem Cell Exhaustion	This stem cell therapy results in significant global correction of the metabolic profile that characterizes the disease, both in the periphery and the central nervous system, the target organ for toxicity in iMSUD.	23566440
Osteosclerosis, Fibrosis Assessment, Primary Myelofibrosis	Stem Cell Exhaustion	Primary myelofibrosis (PM) is a Philadelphia-negative clonal hematopoietic stem cell disorder characterized by intense reactive changes of bone marrow stroma with collagen fibrosis, osteosclerosis and angiogenesis.	23568162
Hypoxia	Stem Cell Exhaustion	Passage-dependent cancerous transformation of human mesenchymal stem cells under carcinogenic hypoxia.	23568779
Specialty Type - cancer	Stem Cell Exhaustion	Bone marrow-derived human mesenchymal stem cells (hMSCs) either promote or inhibit cancer progression, depending on factors that heretofore have been undefined.	23568779
Colorectal Carcinoma, Cytogenetic Complete Response	Stem Cell Exhaustion	Olfactomedin 4 is a useful marker for stem cells in the intestine and is an independent prognostic molecule for survival in patients with colorectal cancer (CRC).	23570326
Colorectal Carcinoma, Malignant tumor of colon	Stem Cell Exhaustion	Prognostic role of p53 messenger ribonucleic acid expression in patients after curative resection for stage I to III colorectal cancer: association with colon cancer stem cell markers.	23571142
Infection of bloodstream	Stem Cell Exhaustion	Comparison of characteristics of bacterial bloodstream infection between adult patients with allogeneic and autologous hematopoietic stem cell transplantation.	23571460
Infection of bloodstream	Stem Cell Exhaustion	Although autologous and allogeneic hematopoietic stem cell transplantation (HSCT) are fundamentally different procedures, a tailored approach to bacterial bloodstream infection (BSI) according to the type of HSCT has not yet been suggested.	23571460
Respiratory Syncytial Virus Infections	Stem Cell Exhaustion	Impact of aerosolized ribavirin on mortality in 280 allogeneic haematopoietic stem cell transplant recipients with respiratory syncytial virus infections.	23572228
Infection	Stem Cell Exhaustion	Respiratory syncytial virus (RSV) infections are well recognized as a significant cause of morbidity and mortality in allogeneic haematopoietic stem cell transplant (allo-HSCT) recipients.	23572228
Experimental Organism Malignant Hepatocholangiocellular Carcinoma, Ductal plate malformation	Stem Cell Exhaustion	Combined hepatocellular-cholangiocarcinoma with stem cell features, ductal plate malformation subtype: a case report and proposal of a new subtype.	23573322
Experimental Organism Malignant Hepatocholangiocellular Carcinoma	Stem Cell Exhaustion	In the current WHO blue book, combined hepatocellular-cholangiocarcinoma (C-HCC-CC) was classified into two types; classical type and type with stem cell features.	23573322
Neoplasms	Stem Cell Exhaustion	The author herein proposes that this tumor should be included or added in the C-HCC-CC subtype as C-HCC-CC with stem cell features, DMP subtype.	23573322
Age related macular degeneration	Stem Cell Exhaustion	To evaluate endothelial progenitor cell [late outgrowth endothelial progenitor cells (OECs)], vascular endothelial growth factor (VEGF), and stromal cell-derived factor 1a (SDF-1a) plasma levels as potential biomarkers before and during ranibizumab (Lucentis((r))) treatment for neovascular age-related macular degeneration (nvAMD).	23573802
Multiple Myeloma	Stem Cell Exhaustion	This phase I/II study was conducted to evaluate the safety and efficacy of bortezomib-melphalan-prednisolone in Japanese patients with previously untreated multiple myeloma who are ineligible for hematopoietic stem cell transplantation.	23574271
Specialty Type - cancer	Stem Cell Exhaustion	Thus, oxidative mitochondrial metabolism (OXPHOS) is a common feature of both (1) normal stem cells and (2) proliferating cancer cells.	23574725
Angina Pectoris	Stem Cell Exhaustion	Endothelial progenitor cells predict long-term prognosis in patients with stable angina treated with percutaneous coronary intervention: five-year follow-up of the PROCREATION study.	23575363
Fracture	Stem Cell Exhaustion	Primary PCI with endothelial progenitor cell-capture stent in patient with skull base fracture and aspirin allergy.	23575723
Multiple Myeloma	Stem Cell Exhaustion	Therapeutic options for patients with recurrent multiple myeloma after autologous stem cell transplantation (ASCT) include novel agents, conventional chemotherapy, or salvage ASCT with no standard of care.	23576287
Multiple Myeloma	Stem Cell Exhaustion	A retrospective review was carried out of the records of patients with multiple myeloma who underwent melphalan-based autologous stem cell transplantation (MEL-ASCT) and developed B19 infection (January 2009-December 2011).	23578205
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Adult acute myeloid leukemia (AML) is a highly heterogeneous stem cell malignancy characterized by the clonal expansion of immature myeloid precursors.	23579575
Lymphopenia	Stem Cell Exhaustion	Successful fludarabine-based hematopoietic stem cell transplantation in a pediatric patient with idiopathic CD4+ lymphocytopenia.	23581828
Heart failure	Stem Cell Exhaustion	Cardiopoietic stem cell therapy in heart failure: the C-CURE (Cardiopoietic stem Cell therapy in heart failURE) multicenter randomized trial with lineage-specified biologics.	23583246
Chronic heart failure	Stem Cell Exhaustion	This study sought to evaluate the feasibility and safety of autologous bone marrow-derived and cardiogenically oriented mesenchymal stem cell therapy and to probe for signs of efficacy in patients with chronic heart failure.	23583246
Heart failure	Stem Cell Exhaustion	In pre-clinical heart failure models, cardiopoietic stem cell therapy improves left ventricular function and blunts pathological remodeling.	23583246
Heart failure	Stem Cell Exhaustion	The C-CURE (Cardiopoietic stem Cell therapy in heart failURE) trial, a prospective, multicenter, randomized trial, was conducted in patients with heart failure of ischemic origin who received standard of care or standard of care plus lineage-specified stem cells.	23583246
Chronic heart failure	Stem Cell Exhaustion	Cardiopoietic stem cell therapy was found feasible and safe with signs of benefit in chronic heart failure, meriting definitive clinical evaluation.	23583246
Shock, Cardiogenic	Stem Cell Exhaustion	In the cell therapy arm, bone marrow was harvested and isolated mesenchymal stem cells were exposed to a cardiogenic cocktail.	23583246
Acute leukemia	Stem Cell Exhaustion	In this randomized, controlled study, 90 patients with recently diagnosed acute leukemia (n = 36) or patients with malignant hemopathies undergoing autologous hematopoietic stem cell transplantation (HSCT) (n = 54) and without LVSD were randomly assigned to a group receiving enalapril and carvedilol (n = 45) or to a control group (n = 45).	23583763
herpesvirus 3, human	Stem Cell Exhaustion	Varicella-zoster virus (VZV) reactivation is a frequent complication after allogeneic hematopoietic stem cell transplantation (HSCT).	23583826
Pure Red-Cell Aplasia	Stem Cell Exhaustion	No standard of care for pure red cell aplasia (PRCA) after major ABO-incompatible hematopoietic stem cell transplantation (HSCT) has been established.	23583828
Specialty Type - cancer	Stem Cell Exhaustion	The aim of our study is to evaluate the surface glycoprotein CD133 as marker of cancer stem cells, as independent prognostic pattern of survival and its positive expression ratio to a chemotherapy increased resistance.	23584268
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Studies comparing the efficacy and cost of stem cell mobilization with intermediate-dose CY (ID-CY) and G-CSF against plerixafor and G-CSF, specifically in multiple myeloma (MM) patients treated in the novel therapy era, are not available.	23584435
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Aldehyde dehydrogenase 1A1 (ALDH1A1) has been characterized as a cancer stem cell marker in different types of tumors.	23585015
Subcapsular Renal Hematoma	Stem Cell Exhaustion	Spontaneous subcapsular splenic hematoma associated with filgrastim in a patient undergoing allogeneic hematopoietic stem cell transplantation.	23585644
Subcapsular Renal Hematoma	Stem Cell Exhaustion	To report the development of a spontaneous subcapsular splenic hematoma following filgrastim administration in a patient undergoing an allogeneic hematopoietic stem cell transplant.	23585644
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	A 60-year-old female with myelodysplastic syndrome was admitted for a reduced-intensity allogeneic hematopoietic stem cell transplant from an unrelated donor.	23585644
Splenic Rupture, filgrastim	Stem Cell Exhaustion	Although splenic rupture attributed to filgrastim in a patient undergoing allogeneic hematopoietic stem cell transplantation has been reported, to our knowledge, this is the first case report to establish causality.	23585644
Splenic Rupture, Splenic hematoma	Stem Cell Exhaustion	Filgrastim has been associated with splenic hematoma and splenic rupture, predominantly in healthy donors undergoing mobilization of peripheral blood stem cells.	23585644
Specialty Type - cancer	Stem Cell Exhaustion	Pathway analysis supported that the miRNAs may regulate signaling associated with induction and maintenance of cancer and stem cell, such as p53, ErbB1, Notch, Wnt, and TGF-b signaling pathways.	23586679
Cessation of life	Stem Cell Exhaustion	Bioinformatic analysis revealed that the differentially expressed miRNAs and their putative target genes were mainly involved in cell death, cellular development, and cellular growth and proliferation, which are the key regulators for stem cells.	23586679
Infection	Stem Cell Exhaustion	Prognostic impact of pretransplant iron overload measured with magnetic resonance imaging on severe infections in allogeneic stem cell transplantation.	23586843
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	In the liver of patients with non-recurrence, expression of PDGFC and other angiogenesis genes, cancer stem cell marker genes, and genes related to tumor progression was down-regulated, while expression of genes related to hepatocyte differentiation, tumor suppression genes, and other genes related to apoptosis induction was up-regulated.	23587162
Ki-1+ Anaplastic Large Cell Lymphoma	Stem Cell Exhaustion	We present a pediatric patient with ALCL who experienced second relapse after standard chemotherapy and autologous and allogeneic hematopoietic stem cell transplantation.	23588340
JAG1 wt Allele	Stem Cell Exhaustion	These AGS effects were shown to be mediated by telomerase since they were not observed when TERT was depleted from hMSC or in mouse embryonic stem cells derived from TERT knockout mice.	23590815
Multiple Myeloma	Stem Cell Exhaustion	Evaluating the effects of lenalidomide induction therapy on peripheral stem cells collection in patients undergoing autologous stem cell transplant for multiple myeloma.	23591714
Failure	Stem Cell Exhaustion	Prior LEN therapy is associated with an increased risk of peripheral blood stem cell collection (PBSC) failure, particularly with filgrastim (G-CSF) alone.	23591714
Carcinoma of bladder, Carcinoma	Stem Cell Exhaustion	Oct-4 as a stem cell marker is expressed in carcinoma cells and in stromal cells of bladder carcinoma, where they may cooperate in the progression of bladder carcinoma by acquiring aggressive features, such as a liability for recurrence and dissemination.	23594289
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Most tumors contain a minor population of cancer stem cells that are responsible for tumor heterogeneity, resistance to therapy and recurrence.	23594289
Ischemic, Acute Coronary Syndrome	Stem Cell Exhaustion	Circulating platelet-progenitor cell coaggregate formation is increased in patients with acute coronary syndromes and augments recruitment of CD34+ cells in the ischaemic microcirculation.	23594593
GDC AJCC Clinical Stage Terminology, Acute myocardial infarction	Stem Cell Exhaustion	These findings imply that circulating platelet/CD34+ cell coaggregate levels are increased in ACS, especially in STEMI, which may be a novel mechanism of domiciliation of CD34+ progenitor cells to the injured microvasculature after acute myocardial infarction.	23594593
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Leukemia stem cells (LSCs) that survive conventional chemotherapy are thought to contribute to disease relapse, leading to poor long-term outcomes for patients with acute myeloid leukemia (AML).	23596204
HCK gene	Stem Cell Exhaustion	We previously identified a Src-family kinase (SFK) member, hematopoietic cell kinase (HCK), as a molecular target that is highly differentially expressed in human primary LSCs compared with human normal hematopoietic stem cells (HSCs).	23596204
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Effect of intensive glycaemic control on endothelial progenitor cells in patients with long-standing uncontrolled type 2 diabetes.	23598596
Vascular System Injuries	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) have an important role in repair following vascular injury.	23598596
Neoplasms	Stem Cell Exhaustion	Sex determining region Y-box 2 (SOX2), is a high mobility group box transcription factor involved in the maintenance of pluripotency and the self-renewal of embryonic and neuronal stem cells, which also plays differential roles in the cell proliferation of several tumors.	23599173
X-linked inheritance, Ancestor	Stem Cell Exhaustion	The patients with X-linked dystonia-parkinsonism also showed a lack of neuropeptide Y labelling in the subventricular zone, where a marked loss of progenitor cells that express proliferating cell nuclear antigen was found.	23599389
Adenoma	Stem Cell Exhaustion	CD24 and CD44 in salivary gland pleomorphic adenoma and in human salivary gland morphogenesis: differential markers of glandular structure or stem cell indicators?	23600676
Mixed Salivary Gland Tumor, Salivary Gland Neoplasms	Stem Cell Exhaustion	Pleomorphic adenoma (PA) is a benign salivary gland neoplasm that comprises epithelial and myoepithelial cells and a complex stroma, whose structure, architecture and origin (from intercalated ducts) suggest stem cell participation.	23600676
Specialty Type - cancer	Stem Cell Exhaustion	We compared the expression of CD24 and CD44 in PA and in developing human salivary glands to investigate whether these markers can be considered as cancer stem cell markers.	23600676
Neoplasms	Stem Cell Exhaustion	PA and stem cells share the expression of CD24 and CD44; their value as markers of neoplastic cell multipotency and the implications of their expression for tumour behaviour are yet to be determined.	23600676
Specialty Type - cancer	Stem Cell Exhaustion	OCT4 is the key gene that controls the automatic renewal of stem cells, and regulates the proliferation and differentiation of cancer stem cells.	23601300
Graft-vs-Host Disease	Stem Cell Exhaustion	Impact of ocular graft-versus-host disease on visual quality of life in patients after allogeneic stem cell transplantation: questionnaire study.	23601505
Complication Aspects	Stem Cell Exhaustion	To determine the influence of ocular complications on quality of life (QoL) 3 years after allogeneic stem cell transplantation (allo-SCT).	23601505
Sample Size Calculation	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) were measured in the peripheral blood of 60 consecutive SSc patients.	23601622
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Long-term clinical implications of embryonic stem cell markers such as Oct4 and Nanog have not been investigated in ST-elevation myocardial infarction (STEMI) patients.	23602281
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Cardiovascular event rates in patients with ST-elevation myocardial infarction were lower with early increases in mobilization of Oct4(high)Nanog(high) stem cells into the peripheral circulation during a 4-year follow-up.	23602281
Childhood Breast Carcinoma	Stem Cell Exhaustion	Side population (SP) cells, exhibiting stem cell-like properties, express ABCG2 (breast cancer resistance protein [BCRP]).	23603434
leukemia, Acute leukemia	Stem Cell Exhaustion	Both the occurrence and recurrence of acute leukemia (AL) might suggest the presence of leukemia stem cells.	23603434
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In acute myeloid leukemia (AML) patients before/after immunotherapy (stem cell transplantation or donor lymphocyte infusion), their suppressive role can contribute to suppress severe graft-versus-host reactions, but also to impair antileukemic reactions.	23603857
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	Early T-cell precursor (ETP) acute lymphoblastic leukemia (ALL) is a high-risk subgroup of T-lineage ALL characterized by specific stem cell and myeloid features.	23603912
Neoplasms	Stem Cell Exhaustion	The tumor promoting effect of PKCa loss was reflected in enhanced Kras-mediated expansion of bronchio-alveolar stem cells (BASCs), putative tumor-initiating cells, both in vitro and in vivo.	23604119
Multiple Myeloma	Stem Cell Exhaustion	Role of high-dose melphalan with autologous stem cell transplantation in multiple myeloma patients receiving botezomib-containing induction therapy.	23605366
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	To examine the role of high-dose melphalan therapy with autologous stem cell transplantation (HDM/ASCT) in the final outcomes of multiple myeloma (MM) patients receiving bortezomib-containing induction therapy (IT), we analyzed relationships between quality of response after IT including bortezomib or HDM/ASCT and survival.	23605366
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Optimal timing of allogeneic hematopoietic stem cell transplantation in patients with myelodysplastic syndrome.	23606215
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HSCT) represents the only curative treatment for patients with myelodysplastic syndrome (MDS), but involves non-negligible morbidity and mortality.	23606215
Childhood Breast Carcinoma	Stem Cell Exhaustion	Resistance to chemotherapy is a major obstacle for the effective treatment of breast cancer and is partially due to the presence of drug resistant stem cell-like side population (SP).	23606360
Specialty Type - cancer	Stem Cell Exhaustion	SP cells showed cancer stem cells (CSCs) properties, including self-renewal, resistance to chemotherapy and high expression of stem cell markers.	23606360
Neutropenia	Stem Cell Exhaustion	Risk factors of Ganciclovir-related neutropenia after allogeneic stem cell transplantation: a retrospective monocentre study on 547 patients.	23607363
Neutropenia	Stem Cell Exhaustion	The aim of this retrospective study was to identify factors associated with the occurrence of grade III-IV neutropenia among patients receiving pre-emptive Ganciclovir therapy after allogeneic stem cell transplantation at our Institution.	23607363
Neutropenia	Stem Cell Exhaustion	This large analysis revealed three risk factors for Ganciclovir-related neutropenia among patients with CMV reactivation after allogeneic stem cell transplantation; prompt identification of patients at risk when antiviral therapy is started may allow clinicians to adopt adequate preventive measures, so reducing the morbidity and mortality associated with CMV reactivation.	23607363
Scleroderma , Sample Size Calculation	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) from scleroderma patients (SSc) preserve their immunomodulatory properties although senescent and normally induce T regulatory cells (Tregs) with a functional phenotype: implications for cellular-based therapy.	23607751
Sample Size Calculation	Stem Cell Exhaustion	The aim of our work was to address how SSc-mesenchymal stem cells (MSCs), although senescent, might preserve specific immunomodulatory abilities during SSc.	23607751
Hematologic Neoplasms	Stem Cell Exhaustion	Plerixafor is a recently introduced agent used to improve peripheral blood stem cell (PBSC) mobilization in patients with hematologic malignancies.	23607889
Malignant neoplasm of stomach	Stem Cell Exhaustion	Immunohistochemical staining was employed to examine expression of stem cell marker CD44 and drug-resistance protein thymidylate synthase (TS) in 71 cases with gastric cancer.	23608803
Malignant neoplasm of stomach	Stem Cell Exhaustion	[Isolation of gastric cancer stem cells based on colony morphology and detection of their sensitivity to 5-fluorouracil].	23608803
Malignant neoplasm of stomach	Stem Cell Exhaustion	To investigate the sensitivity of gastric cancer stem cells (GCSCs) to 5-fluorouracil (5-FU), and to explore the cytological mechanism of drug-resistance of gastric cancer.	23608803
Stomach Carcinoma	Stem Cell Exhaustion	Clinicopathologic significance of putative stem cell marker, CD44 and CD133, in human gastric carcinoma.	23609373
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	We examined the survival of patients with PTCL after relapse or progression in the absence of hematopoietic stem-cell transplantation and explored factors influencing survival.	23610113
Leukemia, Myelomonocytic, Chronic	Stem Cell Exhaustion	[Allogeneic hematopoietic stem cell transplantation for chronic myelomonocytic leukemia: a report of 12 patients].	23611216
Leukemia, Myelomonocytic, Chronic	Stem Cell Exhaustion	To retrospectively review the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for chronic myelomonocytic leukemia (CMML).	23611216
Hematologic Neoplasms	Stem Cell Exhaustion	Patients affected by hematological malignancies can often benefit from high dose chemotherapy followed by peripheral blood stem cells (PBSCs) transplantation.	23611684
Heart failure	Stem Cell Exhaustion	Impact of intracoronary reinfusion of bone marrow-derived mononuclear progenitor cells on cardiopulmonary exercise capacity in patients with chronic postinfarction heart failure.	23612920
Heart failure, Congestive heart failure	Stem Cell Exhaustion	Intracoronary infusion of bone marrow-derived progenitor cells (BMC) in patients with chronic ischaemic heart failure (CHF) is associated with improvement in left ventricular ejection fraction (LVEF), reduction of NT-proBNP levels and improved prognosis.	23612920
Degenerative polyarthritis	Stem Cell Exhaustion	Adipose-derived mesenchymal stem cells exert antiinflammatory effects on chondrocytes and synoviocytes from osteoarthritis patients through prostaglandin E2.	23613363
Degenerative polyarthritis	Stem Cell Exhaustion	To examine the effect of different sources of good manufacturing practice clinical grade adipose-derived mesenchymal stem cells (AD-MSCs) on inflammatory factors in osteoarthritic (OA) chondrocytes and synoviocytes.	23613363
Intraepithelial Neoplasia, Specialty Type - cancer, Squamous cell carcinoma	Stem Cell Exhaustion	Putative cancer stem cell marker expression in oral epithelial dysplasia and squamous cell carcinoma.	23614644
Specialty Type - cancer	Stem Cell Exhaustion	Semi-quantitative immunohistochemical assessment of four putative cancer stem cell markers (CD24, CD44, CD271 and ALDH1) was conducted with a training cohort of 107 patient biopsies to establish clinically applicable score threshold values that were subsequently applied to a blind diagnosis in an independent validation cohort of 278 biopsies.	23614644
Specialty Type - cancer	Stem Cell Exhaustion	The hypothesised existence of cancer stem cells in dysplastic oral tissues provides the potential for more informed assessment of PMOL progression.	23614644
Stomach Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	WNT5A is a key regulator of the epithelial-mesenchymal transition and cancer stem cell properties in human gastric carcinoma cells.	23615002
Specialty Type - cancer	Stem Cell Exhaustion	Transduction of exogenous WNT5A expression into MKN-7 cells upregulated genes related to the epithelial-mesenchymal transition (EMT) and cancer stem cells (CSCs), and the pWNT5A transfectant showed high tumorigenicity in vivo.	23615002
Multiple Myeloma	Stem Cell Exhaustion	Bisphosphonate treatment and renal function in 201 myeloma patients undergoing stem cell transplantation.	23616219
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Normal karyotype mosaicism in adult AML patients with adverse-risk and undefined karyotype: preliminary report of treatment outcomes after hematopoietic stem cell transplantation.	23616221
Aggressive behavior, Hollings Cancer Center, Secondary Neoplasm	Stem Cell Exhaustion	In HCC, presence of stem cell-like, epithelial cell adhesion molecule (EpCAM)-positive cells correlates with tumor aggressiveness and formation of metastasis.	23616258
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	We evaluated the predictive value of [(18)F]fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) for clinical outcome such as progression-free survival (PFS) and overall survival (OS) in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) prior to and after autologous stem cell transplant (ASCT).	23617323
Stanford Cancer Institute	Stem Cell Exhaustion	Subjects with SCI also exhibited significantly higher plasma levels of monokine induced by interferon-gamma/chemokine C-X-C motif ligand 9 (P<.03), macrophage colony stimulating factor (P<.035), interleukin-3 (P<.044), and stem cell growth factor beta (SCGF-b) (P<.016).	23618747
Glioblastoma Multiforme Pathway, Neoplasms	Stem Cell Exhaustion	It has been shown to suppress the tumourigenicity of glioma stem cells in vivo, thereby being hypothesised to function as a tumour suppressor.	23619925
Bone Marrow, Leukemia, Myelocytic, Acute, peripheral blood	Stem Cell Exhaustion	Univariate analysis identified the absence of peripheral blood blasts and <20% bone marrow blasts as prognostic factors for both overall response and survival, but not age, ECOG/PS, type of AML, cytogenetic, status of the disease, number of previous lines of therapy, previous hematological stem cell transplantation, or white blood cells count.	23619977
Acute lymphocytic leukemia	Stem Cell Exhaustion	Comparable long-term outcomes after reduced-intensity conditioning versus myeloablative conditioning allogeneic stem cell transplantation for adult high-risk acute lymphoblastic leukemia in complete remission.	23620000
Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease in a nonhematopoietic stem cell transplantation candidate treated with decitabine followed by granulocyte colony-stimulating factor-primed peripheral blood stem cells infusion: a special entity of the disease?	23621702
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	With a well-developed strategy of acute graft-versus-host disease (aGVHD) prophylaxis, the prognosis of allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients who develop aGVHD has improved considerably.	23621702
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This report describes a 64-year-old male non-HSCT candidate diagnosed with acute myeloid leukemia who had received decitabine followed by an infusion of granulocyte-colony-stimulating factor-primed peripheral blood stem cells (G-PBSCs) from his daughter, who carried haploidentical human leukocyte antigen.	23621702
Kidney Failure, Chronic, Dominica, Diabetes Mellitus	Stem Cell Exhaustion	The aim of this study was to investigate the effect of end-stage renal disease (ESRD) and diabetes mellitus (DM) on the number of stem cells in the peripheral blood.	23625296
Gastrointestinal mucositis	Stem Cell Exhaustion	Oral mucositis (OM) is one of the side effects of hematopoietic stem cell transplantation (HSCT), resulting in major morbidity.	23625880
Degenerative polyarthritis	Stem Cell Exhaustion	Mesenchymal stem cell (MSC)-based therapy presents a promising approach for treating osteoarthritis (OA).	23627821
Hodgkin Disease, Neoplasms, Childhood Non-Hodgkin Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	We enrolled a total of 145 patients into the study (non-Hodgkin lymphoma (n: 40), Hodgkin lymphoma (n: 36), myeloma (n: 64), solid tumors (n:5)) who received autologous stem cell transplantation between 2009 and 2012.	23628357
Mycoses	Stem Cell Exhaustion	Voriconazole (VCZ) is frequently utilized for prevention and treatment of invasive fungal infections in peripheral stem cell transplant (PSCT) patients.	23629717
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The survival of patients with relapsed acute myelogenous leukemia (AML) after autologous hematopoietic stem cell transplantation (auto-HCT) is very poor.	23632091
Hematopoietic Stem Cell Mobilization	Stem Cell Exhaustion	If their effectiveness is confirmed, statins could be a safe and cheaper addition to chemotherapy and plerixafor for peripheral hematopoietic stem cell mobilization.	23632813
Multiple Myeloma	Stem Cell Exhaustion	This study examines if statins may have the same effect in mobilizing marrow progenitors to be harvested and subsequently used in high-dose chemotherapy with progenitor cell rescue in multiple myeloma.	23632813
Multiple Myeloma	Stem Cell Exhaustion	Statin use and peripheral blood progenitor cells mobilization in patients with multiple myeloma.	23632813
Multiple Myeloma	Stem Cell Exhaustion	This retrospective analysis of 86 patients shows for the first time a possible benefit of statins for peripheral blood progenitor cells mobilization in patients with multiple myeloma.	23632813
Agave	Stem Cell Exhaustion	GAVE can develop as a complication of hematopoietic stem cell transplantation (HSCT-GAVE), and it has been suggested that it may be associated with oral administration of busulfan.	23632949
Hematologic Neoplasms	Stem Cell Exhaustion	Donor leukocyte infusion (DLI) can induce potent graft-versus-leukemia (GVL) activity in patients with relapsed hematologic malignancies after allogeneic hematopoietic stem cell transplantation (HSCT).	23635453
Musculoskeletal, Specialty Type - cancer	Stem Cell Exhaustion	Sphere-forming cell subsets with cancer stem cell properties in human musculoskeletal sarcomas.	23636271
Sarcoma, Specialty Type - cancer	Stem Cell Exhaustion	Here, we report the identification of putative cancer stem cells (CSCs) in sarcomas using a sphere culture system.	23636271
Lymphoproliferative Disorders	Stem Cell Exhaustion	The kinetics and apoptotic profile of circulating endothelial cells in autologous hematopoietic stem cell transplantation in patients with lymphoproliferative disorders.	23636312
Malignant Neoplasms, Multiple Myeloma	Stem Cell Exhaustion	Measurements of circulating endothelial cells (CEC), their subsets and kinetics were taken in patients with lymphoid malignancies (37 multiple myeloma, ten lymphoma) during autologous hematopoietic stem cell transplantation (HSCT).	23636312
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSCs) refer to a subset of tumor cells that self-renew and affect tumor heterogeneity.	23636800
SERPINB3 wt Allele, Specialty Type - cancer	Stem Cell Exhaustion	The objective of this study was to determine protein expression of cancer stem cell factor Bmi1 in a longitudinal series of patients with OLP and evaluate the correlation between Bmi1 expression and the risk of progression to OSCC.	23639414
Vascular System Injuries	Stem Cell Exhaustion	Although endothelial progenitor cells (EPCs) have been reported to promote neovessel formation during vascular injury, the function of supporting cells of EPCs and their interaction with EPCs during EPC isolation remain unclear.	23640491
Retinoblastoma	Stem Cell Exhaustion	Retinoblastoma is the most common primary intraocular malignancy of childhood, arising from retinal progenitor cells.	23640512
Cystitis, Neoplasms, Carcinoma, Transitional Cell	Stem Cell Exhaustion	In some cases, tumor development is thought to be associated with Brunns nests, cystitis cystica and urothelial carcinoma stem cells.	23641713
Malignant tumor of colon	Stem Cell Exhaustion	A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells.	23642368
Malignant tumor of colon, Neoplasms	Stem Cell Exhaustion	Here, we show that the tumor suppressor microRNA miR-34a is a cell-fate determinant in early-stage dividing colon cancer stem cells (CCSCs).	23642368
Multiple Myeloma	Stem Cell Exhaustion	In this study, we retrospectively analyzed MRD by quantitative real-time IgH-PCR (IgH-qPCR) in the PB of 42 patients undergoing high-dose therapy followed by autologous PB stem cell transplantation as first-line therapy for multiple myeloma.	23644045
Acute lymphocytic leukemia	Stem Cell Exhaustion	Outcomes of adults with acute lymphoblastic leukemia relapsing after allogeneic hematopoietic stem cell transplantation.	23644077
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	For patients with acute lymphoblastic leukemia (ALL) who relapse after allogeneic hematopoietic stem cell transplantation (HSCT), treatment options are limited, and the clinical course and prognostic factors affecting outcome have not been well characterized.	23644077
Goiter	Stem Cell Exhaustion	In thyroid stem/progenitor cells derived from nodular goitres, the ability of 17b-oestradiol (E2) to induce the formation of thyrospheres and the expression of oestrogen receptors (ERs) and the effect of E2 on the growth and expression of markers of stem cells and thyroid differentiation (TSH receptor, thyroperoxidase, thyroglobulin and sodium iodide symporter (NIS)) were analysed.	23645248
Multiple Myeloma	Stem Cell Exhaustion	Natural history and prognostic impact of oligoclonal humoral response in patients with multiple myeloma after autologous stem cell transplantation: long-term results from a single institution.	23645688
Multiple Myeloma	Stem Cell Exhaustion	The emergence of an oligoclonal humoral response, resulting in the appearance of a different serum M-protein to that observed at diagnosis is a well-recognized event after autologous stem cell transplantation in multiple myeloma in complete response, and it has been considered to be a benign phenomenon.	23645688
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	We conclude that escalated subcutaneous doses of alemtuzumab given weekly are well tolerated and result in excellent bone marrow clearance of chronic lymphocytic leukemia, helping patients to proceed to stem cell transplantation.	23645694
Intrahepatic Cholangiocarcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Clinical significances of cancer stem cells markers in patients with intrahepatic cholangiocarcinoma who underwent hepatectomy.	23645762
Intrahepatic Cholangiocarcinoma, Specialty Type - cancer	Stem Cell Exhaustion	The present study aimed to elucidate the relationship between cancer stem cells markers (CSCs), according to cell adhesion molecule (CD44) and glioma-associated oncogene homolog-1 (GLI1) expression, and clinicopathological factors and prognosis in 38 patients with intrahepatic cholangiocarcinoma (ICC) who underwent hepatectomy.	23645762
Acute leukemia	Stem Cell Exhaustion	A phase I study of CPX-351 in combination with busulfan and fludarabine conditioning and allogeneic stem cell transplantation in adult patients with refractory acute leukemia.	23648237
Acute leukemia	Stem Cell Exhaustion	This phase I study evaluated the maximal tolerated dose of CPX-351 when administered sequentially with allogeneic hematopoietic stem cell transplantation (HSCT) in patients with refractory acute leukemia.	23648237
Inflammatory Bowel Diseases, Colitis, HIV Infections	Stem Cell Exhaustion	We therefore evaluated quantitative, real-time CMV PCR in a total of 102 FFPE GI biopsy specimens from 74 patients with a history of hematopoietic stem cell or solid organ transplant, inflammatory bowel disease, human immunodeficiency virus infection, or unspecified colitis.	23648457
Multiple Myeloma	Stem Cell Exhaustion	The response to second-line induction with bortezomib and dexamethasone is predictive of long-term outcomes prior to high-dose chemotherapy with autologous stem cell transplantation for multiple myeloma.	23648714
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We retrospectively investigated the efficacy and predictive factors for the treatment outcomes of bortezomib plus dexamethasone (BD) as second-line induction therapy prior to high-dose chemotherapy supported by autologous stem cell transplantation (HDT/ASCT) in multiple myeloma (MM) patients.	23648714
Hematologic Neoplasms	Stem Cell Exhaustion	In this study, we retrospectively evaluated the antiemetic effectiveness and safety of aprepitant (a neurokinin-1 receptor antagonist) in addition to 5-HT3 antagonist in Japanese patients with hematologic malignancy receiving high-dose chemotherapy prior to autologous peripheral blood stem cell transplantation (auto-PBSCT).	23649338
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Effective and less aggressive therapies are required for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) who are not eligible for or have undergone autologous stem-cell transplantation (ASCT).	23650408
Acute myocardial infarction	Stem Cell Exhaustion	A critical challenge: dosage-related efficacy and acute complication intracoronary injection of autologous bone marrow mesenchymal stem cells in acute myocardial infarction.	23651816
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Steroid refractory gastrointestinal (GI) acute graft-versus-host disease (aGVHD) is a major cause of mortality in hematopoietic stem cell transplantation (HCT) without immune markers to establish a diagnosis or guide therapy.	23652802
Colitis	Stem Cell Exhaustion	He was treated with 1 course of methylprednisolone pulse therapy and the clinical symptoms improved; however, the colitis was difficult to control even with immunosuppressive drugs, and he eventually required hematopoietic stem cell transplantation 1 year after the onset of MAS.	23652865
Encephalomyelitis, Acute Disseminated, Encephalomyelitis, Acute leukemia, Acute lymphocytic leukemia	Stem Cell Exhaustion	Acute disseminated encephalomyelitis (ADEM) has been reported in acute leukemia and after stem cell transplantation, but ADEM as a presenting feature in pediatric acute lymphoblastic leukemia is rare.	23652871
Hypogonadism	Stem Cell Exhaustion	Testosterone replacement therapy can increase circulating endothelial progenitor cell number in men with late onset hypogonadism.	23653307
Hematologic Neoplasms	Stem Cell Exhaustion	Colistin is relatively safe in hematological malignancies and hematopoietic stem cell transplantation patients.	23653428
Hematologic Neoplasms, Toxic effect	Stem Cell Exhaustion	The aim of this study was to analyze the toxicity of colistin therapy in adults and children with hematological malignancies (HM) and hematopoietic stem cell transplantation (HSCT) recipients.	23653428
Decreased platelet count	Stem Cell Exhaustion	Eligible patients were persons 16 years of age or older who were receiving chemotherapy or undergoing stem-cell transplantation and who had or were expected to have thrombocytopenia.	23656642
Hemorrhage	Stem Cell Exhaustion	A prespecified subgroup analysis identified similar rates of bleeding in the two study groups among patients undergoing autologous stem-cell transplantation.	23656642
Adenocarcinoma of lung (disorder), Specialty Type - cancer	Stem Cell Exhaustion	Pulmonary Adenocarcinoma in Malignant Pleural Effusion Enriches Cancer Stem Cell Properties during Metastatic Cascade.	23658677
Specialty Type - cancer	Stem Cell Exhaustion	The objective of the current study was to confirm whether cancer stem cells (CSCs) in MPE contribute to the "metastatic cascade" through the epithelial - mesenchymal transition (EMT), anoikis, and adaptation in the microenvironment.	23658677
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GVHD) is associated with morbidity and mortality in the recipients of allogeneic hematopoietic stem cell transplants (allo-HSCTs).	23659674
Trial Disease Assessments Domain, Multiple Myeloma	Stem Cell Exhaustion	We performed a molecular study aimed at identifying a gene expression profile (GEP) signature predictive of attainment of at least near complete response (CR) to thalidomide-dexamethasone (TD) as induction regimen in preparation for double autologous stem cell transplantation in 112 younger patients with newly diagnosed multiple myeloma.	23660628
Aspergillosis	Stem Cell Exhaustion	Comparison of a novel Aspergillus lateral-flow device and the Platelia(r) galactomannan assay for the diagnosis of invasive aspergillosis following haematopoietic stem cell transplantation.	23661288
Hyperpigmentation, Melanosis	Stem Cell Exhaustion	We previously reported that increased expression of the endothelin (EDN)1/EDNB receptor (EDNBR) as well as the stem cell factor (SCF)/SCF receptor (c-KIT) linkages is mainly responsible for the activation of melanocytes in the epidermal hyperpigmentation of ultraviolet (UV)-B melanosis and lentigo senilis (LS).	23662587
B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1, BCR gene	Stem Cell Exhaustion	Hematopoietic stem cell transplant versus chemotherapy plus tyrosine kinase inhibitor in the treatment of pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL).	23664604
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We report a case of 53year old female with history of acute myelogenous leukemia, for which she underwent allogeneic peripheral blood stem cell transplant; her course was complicated by chronic graft versus host disease.	23664606
Toxic effect, Comorbidity	Stem Cell Exhaustion	Reduced toxicity conditioning and allogeneic stem cell transplantation in adults using fludarabine, carmustine, melphalan, and antithymocyte globulin: outcomes depend on disease risk index but not age, comorbidity score, donor type, or human leukocyte antigen mismatch.	23664940
Cardiovascular Diseases, Diabetes	Stem Cell Exhaustion	Here we report the effects of NO on both promotion and inhibition of cell proliferation, in particular in regard to cardiovascular disease, diabetes, and stem cells.	23665095
Failure	Stem Cell Exhaustion	This case illustrates that SLET is effective in treating LSCD even in cases that are conventionally considered to be at high risk for failure of limbal stem cell transplantation.	23667247
Multiple Myeloma	Stem Cell Exhaustion	[Analysis of the efficacy and prognosis on first-line autologous hematopoietic stem cell transplantation of patients with multiple myeloma].	23668200
Trial Disease Assessments Domain	Stem Cell Exhaustion	All patients received thalidomide or/and bortezomib-based induction therapy, then received high-dose melphalan (200 mg/m2) and autologous stem cell support to get a >= partial response (PR), and followed by thalidomide-dexamethasone (TD) +-bortezomib as consolidation or maintenance treatment.	23668200
Multiple Myeloma, Communicable Diseases	Stem Cell Exhaustion	[Observation of humoral immunity reconstitution and its relationship with infection after autologous hematopoietic stem cell transplantation for patients with multiple myeloma].	23668204
Morular Metaplasia of the Endometrium, Multiple Myeloma, Communicable Diseases	Stem Cell Exhaustion	To study the humoral immunity reconstitution and its relationship with infection in patients with multiple myeloma (MM) after undergoing autologous hematopoietic stem cell transplantation (auto-HSCT).	23668204
Multiple Myeloma	Stem Cell Exhaustion	[Clinical significance of abnormal protein bands in multiple myeloma treated with bortezomib-based induction regimen and autologous stem cell transplantation].	23668206
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	To study the clinical significance of abnormal protein bands (APB) in multiple myeloma (MM) patients treated with bortezomib-based induction regimen and autologous stem cell transplantation (ASCT).	23668206
Degenerative polyarthritis	Stem Cell Exhaustion	Similar properties of chondrocytes from osteoarthritis joints and mesenchymal stem cells from healthy donors for tissue engineering of articular cartilage.	23671648
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	BAALC and WT1 expressions from diagnosis to hematopoietic stem cell transplantation: consecutive monitoring in adult patients with core-binding-factor-positive AML.	23672350
Core binding factor acute myeloid leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	No consecutive analysis of BAALC and WT1 expressions associated with core-binding factor AML (CBF-AML) from diagnosis to hematopoietic stem cell transplantation (HSCT) has yet been reported.	23672350
Malignant Neoplasms	Stem Cell Exhaustion	Various experimental studies indicate potential involvement of bone marrow (BM)-derived stem cells (SCs) in malignancy development and progression.	23672538
Pancreatic carcinoma	Stem Cell Exhaustion	In contrast to previous studies, we demonstrate herein that systemic SDF-1 levels do not seem to be linked with increased mobilization of stem cells in patients with pancreatic cancer.	23672538
Pancreatic carcinoma	Stem Cell Exhaustion	An intensified systemic trafficking of bone marrow-derived stem/progenitor cells in patients with pancreatic cancer.	23672538
Pancreatic carcinoma	Stem Cell Exhaustion	In this study, we comprehensively analysed systemic trafficking of various populations of BM-derived SCs (BMSCs), i.e., mesenchymal, haematopoietic, endothelial stem/progenitor cells (MSCs, HSCs, EPCs respectively), and of recently discovered population of very small embryonic/epiblast-like SCs (VSELs) in pancreatic cancer patients.	23672538
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 3-year-old girl with acute myeloid leukemia underwent unrelated cord blood stem cell transplantation (UCBT) due to primary induction failure.	23676648
Zygomycosis	Stem Cell Exhaustion	[Fatal zygomycosis caused by Mucor indicus after haplo-identical stem cell transplantation].	23676649
Acute lymphocytic leukemia	Stem Cell Exhaustion	We report the case of a 10 year old girl with a relapsed acute lymphoblastic leukemia, who underwent a haploidentical hematopoietic stem cell transplant (HSCT), with grade II skin and digestive graft versus host disease, treated with corticosteroids and cyclosporine.	23677159
Aortic Aneurysm, Abdominal	Stem Cell Exhaustion	Perspectives on stem cell-based elastic matrix regenerative therapies for abdominal aortic aneurysms.	23677642
Specialty Type - cancer, Pancreatic carcinoma	Stem Cell Exhaustion	CD44(+) /CD24(+) /EpCAM(+) cells have been reported to be cancer stem cells in pancreatic cancer; however, the histological and clinical importance of these cells has not yet been investigated.	23679813
Chronic granulomatous disease	Stem Cell Exhaustion	Successful Unrelated Cord Blood Stem Cell Transplantation in an X-linked Chronic Granulomatous Disease Patient with Disseminated BCG-induced Infection.	23680261
In-Stent Restenosis Indicator, Acute Coronary Syndrome	Stem Cell Exhaustion	Circulating endothelial progenitor cells are inversely correlated with in-stent restenosis in patients with non-ST-segment elevation acute coronary syndromes treated with EPC-capture stents (JACK-EPC trial).	23681133
GDC AJCC Clinical Stage Terminology, Acute Coronary Syndrome	Stem Cell Exhaustion	Aim of the study was to evaluate the association between circulating endothelial progenitor cells (EPCs) and angiographic outcomes after implantation of GenousTM stent in patients with non-ST-segment elevation acute coronary syndromes (ACS) (NSTE-ACS) undergoing urgent percutaneous coronary intervention (PCI).	23681133
Specialty Type - cancer	Stem Cell Exhaustion	Circulating endothelial cells (CECs), endothelial progenitor cells (EPCs), Willebrand factor (vWf), soluble E-selectin, vascular endothelial growth factor (VEGF) and angiogenin are of interest in cancer vascular biology.	23683169
Malignant neoplasm of lung	Stem Cell Exhaustion	The purpose of this study is to investigate the differential expression and clinical significance of seven stem-cell-associated markers (Bmi1, CD133, CD44, Sox2, Nanog, OCT4 and Msi2) in lung cancer, providing new targets for the diagnosis and treatment of lung cancer.	23683495
Malignant neoplasm of lung, Non-Cancer Related Death	Stem Cell Exhaustion	In this study, we evaluated the differential expression of mRNA levels seven stem-cell-associated markers by semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) from 112 human lung cancer and 18 non-cancer tissues obtained by bronchoscopy.	23683495
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Prognostic factors for outcomes of allogeneic stem cell transplantation in chronic phase chronic myeloid leukemia in the era of tyrosine kinase inhibitors.	23684143
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The aim of this study was to estimate the prognostic factors for the outcomes of chronic myeloid leukemia (CML) patients receiving allogeneic stem cell transplantation (SCT) in chronic phase (CP) in the era of tyrosine kinase inhibitors (TKIs).	23684143
Disease, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Acute leukemia, hematopoietic stem cell differentiation	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell disorders characterized by abnormal hematopoietic differentiation and maturation, which progress toward acute leukemia in approximately 30% of the cases.	23684483
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Tumors of the mesenchymal subtype contain cells with features of cancer stem cells, and cell lines of this subtype are particularly sensitive to phosphatidylinositol 3-kinase-AKT-mTOR inhibitors in vitro.	23684942
Multiple Myeloma	Stem Cell Exhaustion	Vaccination with dendritic cell/tumor fusions following autologous stem cell transplant induces immunologic and clinical responses in multiple myeloma patients.	23685836
Aspergillosis	Stem Cell Exhaustion	Given the difficulty in distinguishing S. commune infection from aspergillosis by standard culture methods, the incidence of S. commune infection following allogeneic hematopoietic stem cell transplantation may be underestimated.	23686329
Inflammation, Endothelial dysfunction, Platelet aggregation	Stem Cell Exhaustion	Inhibition of platelet aggregation by nitric oxide (primary outcome measure), vascular endothelial function, plasma concentrations of N(G), N(G)-dimethyl-L-arginine (ADMA), endothelial progenitor cell count, and high-sensitivity C-reactive protein (markers of endothelial dysfunction and inflammation) were assessed.	23688663
Mycoses	Stem Cell Exhaustion	[Itraconazole for secondary prophylaxis of invasive fungal infection in patients undergoing chemotherapy and stem cell transplantation].	23688752
Agranulocytosis lab result, Mycoses	Stem Cell Exhaustion	To evaluate the efficacy and safety of itraconazole for secondary prophylaxis of previous proven or probable invasive fungal infection (IFI) in patients undergoing chemotherapy or allogeneic hematopoietic stem cell transplantation (HSCT) in agranulocytosis state.	23688752
Bone Marrow, Hypernatremia	Stem Cell Exhaustion	Mechanisms underlying bone marrow damage by iron overload might be through the follows: 1The increased ROS induced by excessive iron deposition affected the expressions of Caspase-3 and Bcl-2, which caused more BMMNC apoptosis; 2The abnormal number and ratio of T lymphocytes caused by iron overload aggravated the abnormality of immunity of IRP; 3Iron overload may increase the damage to erythrocytes and stem cells coated with auto-antibodies.	23688756
Waldenstrom Macroglobulinemia, Amyloidosis	Stem Cell Exhaustion	Waldenstrom's macroglobulinemia associated with serum amyloid A protein amyloidosis: pitfalls in diagnosis and successful treatment with melphalan-based autologous stem cell transplant.	23689541
Amyloidosis	Stem Cell Exhaustion	Autologous stem cell transplant (ASCT) is now being increasingly used for the treatment of amyloidosis, but most studies are small case series.	23689541
Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	In contrast, HCC/immortality genes were up-regulated in tumor tissues, or more malignant tumors and progenitor cells.	23691139
Infection	Stem Cell Exhaustion	Successful systemic high-dose ribavirin treatment of respiratory syncytial virus-induced infections occurring pre-engraftment in allogeneic hematopoietic stem cell transplant recipients.	23692664
Upper Respiratory Infections, Communicable Diseases	Stem Cell Exhaustion	Respiratory syncytial virus (RSV) is a frequent cause of respiratory tract infectious disease (RTID) in allogeneic hematopoietic stem cell transplant (HSCT) recipients associated with a high mortality once infection has progressed from upper RTID (URTID) to lower RTID (URTID).	23692664
Toxic effect	Stem Cell Exhaustion	Toxicity was largely hematologic, and stem cell mobilization was successful in 43 of 45 patients.	23692856
Neoplasms	Stem Cell Exhaustion	The residual tumors after response to the chemotherapy exhibited an increased expression in 51 (61%) of 84 genes related with stem cell proliferation and maintenance, particularly those in Notch and Wnt pathways, suggesting enrichment for stem cell populations in the residual tumors.	23695169
Specialty Type - cancer	Stem Cell Exhaustion	Anti-HDGF targets cancer and cancer stromal stem cells resistant to chemotherapy.	23695169
Non-Small Cell Lung Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	These data support the hypothesis that cancer stem cells (CSC) are a mechanism for chemotherapy resistance and suggest HDGF may be a target for repressing CSCs to prevent relapse of NSCLC sensitive to chemotherapy.	23695169
Immune System Diseases	Stem Cell Exhaustion	Discoveries of immunomodulatory functions in mesenchymal stem cells (MSCs) have suggested that they might have therapeutic utility in treating immune diseases.	23697344
Hodgkin Disease	Stem Cell Exhaustion	Improved outcome with busulfan, melphalan and thiotepa conditioning in autologous hematopoietic stem cell transplant for relapsed/refractory Hodgkin lymphoma.	23697844
Hodgkin Disease	Stem Cell Exhaustion	High-dose therapy with autologous stem cell transplant (autoSCT) is standard therapy for relapsed/refractory Hodgkin lymphoma, although the optimal conditioning regimen remains uncertain.	23697844
Malignant neoplasm of testis	Stem Cell Exhaustion	Plerixafor and autologous stem cell transplantation: impressive result in a chemoresistant testicular cancer patient treated with high-dose chemotherapy.	23698254
Lymphoma, Non-Hodgkin, Multiple Myeloma	Stem Cell Exhaustion	Plerixafor, a CXCR4 antagonist, induces the rapid release of hematopoietic progenitor stem cells from the bone marrow into peripheral blood; it is approved for autologous hematopoietic progenitor stem cell mobilization in multiple myeloma and non-Hodgkin's lymphoma patients.	23698254
Testicular Embryonal Carcinoma	Stem Cell Exhaustion	We report the case of a 34-year-old patient with metastatic testicular embryonal carcinoma who was extensively and in vain pretreated with chemotherapy and failed to mobilize an adequate number of hematopoietic progenitor stem cells following high-dose chemotherapy, with the support of granulocyte colony-stimulating factors.	23698254
Hypertension, CTCAE	Stem Cell Exhaustion	Bartter's/Gitelman's syndromes (BS/GS) are rare diseases that feature a picture opposite to that of hypertension in that they present with normo/hypotension, reduced oxidative stress and a lack of cardiovascular remodeling, notwithstanding high levels of angiotensin II and other vasopressors, upregulation of NO system, and increased NO-dependent vasodilation (FMD), as well as increase in both endothelial progenitor cells and insulin sensitivity.	23698802
Reperfusion Injury	Stem Cell Exhaustion	Erythropoietin (EPO) was hypothesized to mitigate reperfusion injury, in part via mobilization of endothelial progenitor cells (EPCs).	23700090
Nonunion of Bone	Stem Cell Exhaustion	The use of growth factors and autologous mesenchymal stem cells through the enforcement of system for tissue regeneration is a valid and innovative biotechnology technique for the treatment long bone nonunions.	23700322
Specialty Type - cancer	Stem Cell Exhaustion	Based on their main biological characteristics, we distinguished a deficient mismatch repair subtype, a KRAS mutant subtype, a cancer stem cell subtype, and three chromosomal instability subtypes, including one associated with down-regulated immune pathways, one with up-regulation of the Wnt pathway, and one displaying a normal-like gene expression profile.	23700391
Primary Myelofibrosis, Cytopenia, Adverse Event Associated with Constitutional Symptoms, Splenomegaly, PRSS27 gene	Stem Cell Exhaustion	Myelofibrosis (MF) is a Philadelphia chromosome-negative stem cell myeloproliferative neoplasm (MPN) associated with cytopenias, splenomegaly, constitutional symptoms, and poor prognosis.	23701016
Hematologic Neoplasms	Stem Cell Exhaustion	The study included 110 consecutive patients with hematological malignancies receiving fludarabine-based reduced intensity conditioning (RIC) and hematopoietic stem cell transplantation (HSCT) from matched unrelated donors.	23701240
Duodenal Ulcer	Stem Cell Exhaustion	Recently we conducted the genome wide association study for duodenal ulcer and identified disease susceptibility variations at two genetic loci corresponding to the Prostate stem cell antigen (PSCA) gene and the ABO blood group (ABO) gene.	23704932
SERPINB3 wt Allele, Specialty Type - cancer	Stem Cell Exhaustion	The objective of this study was to determine protein expression of cancer stem cell marker aldehyde dehydrogenase 1 (ALDH1) in a series of patients with OLP and evaluate the correlation between ALDH1 expression and the risk of progression to OSCC.	23707659
Angina Pectoris, Ischemia	Stem Cell Exhaustion	Patients (n = 444) receiving maximally tolerated antianginal therapies and lacking conventional revascularization options with Canadian Cardiovascular Society class III or IV angina and ischemia on stress testing will be randomized 2:1:1 to cell therapy (G-CSF-mediated stem cell mobilization, apheresis, and intramyocardial injection of 1 x 10(5) autologous CD34(+) cells/kg), active control (G-CSF-mediated stem cell mobilization, apheresis, and intramyocardial placebo injection), or open-label standard of care.	23708155
Angina Pectoris, Chronic myocardial ischemia	Stem Cell Exhaustion	RENEW is a pivotal phase 3 trial designed to determine the efficacy of granulocyte colony-stimulating factor (G-CSF)-mobilized CD34+ stem cells for the treatment for patients with refractory angina and chronic myocardial ischemia.	23708155
Multiple Myeloma	Stem Cell Exhaustion	Reduced intensity-conditioned allogeneic stem cell transplantation for multiple myeloma relapsing or progressing after autologous transplantation: a study by the European Group for Blood and Marrow Transplantation.	23708704
Kidney Failure, Chronic, Diabetes Mellitus, Insulin-Dependent	Stem Cell Exhaustion	Co-infusion of adipose tissue derived mesenchymal stem cell-differentiated insulin-making cells and haematopoietic cells with renal transplantation: a novel therapy for type 1 diabetes mellitus with end-stage renal disease.	23709153
Kidney Failure, Chronic	Stem Cell Exhaustion	We report a 30-year-old-man with T1DM since 15 years and ESRD since 2 years, who underwent living donor RT and co-infusion of in vitro generated insulin-making cells differentiated from donor adipose tissue derived mesenchymal stem cells and bone marrow -derived haematopoietic SC into subcutaneous tissue, portal and thymic circulation under non-myeloablative conditioning.	23709153
Spinal Cord Injuries, Muscle Spasticity	Stem Cell Exhaustion	Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation.	23710605
Trauma	Stem Cell Exhaustion	Intraspinal grafting of human neural stem cells represents a promising approach to promote recovery of function after spinal trauma.	23710605
Crushing injury	Stem Cell Exhaustion	Here we characterized the effect of intraspinal grafting of clinical grade human fetal spinal cord-derived neural stem cells (HSSC) on the recovery of neurological function in a rat model of acute lumbar (L3) compression injury.	23710605
Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic graft-versus-host disease of the kidney in patients with allogenic hematopoietic stem cell transplant.	23710658
Hematological Disease	Stem Cell Exhaustion	Allogenic hematopoietic stem cell transplant (allo-HSCT) is the treatment of choice for several hematological diseases.	23710658
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Vaginal chronic graft-versus-host disease (cGVHD) is a common complication of stem cell transplantation.	23710698
Antilymphocyte Serum	Stem Cell Exhaustion	We have recently shown that human mesenchymal stem cells (hMSCs) modified to release glial cell line-derived neurotrophic factor (GDNF) decrease disease progression in a rat model of ALS when delivered to skeletal muscle.	23712039
Pregnancy Complications, Infectious, Immunocompromised Host	Stem Cell Exhaustion	Immunocompromised hematological patients undergoing cyclic chemotherapy treatment or allogeneic hemopoietic stem cell transplantation with infectious complications in which the infectious agents were identified during the disease course were evaluated.	23712521
Malignant neoplasm of lung	Stem Cell Exhaustion	In this study, we investigated the potential of the stem cell and progenitor cell marker, Musashi1 (Msi1), as a diagnostic marker and potential therapeutic target for lung cancer.	23715514
Trichoepithelioma	Stem Cell Exhaustion	PHLDA1, a follicular stem cell marker, differentiates clear-cell/granular-cell trichoblastoma and clear-cell/granular cell basal cell carcinoma: a case-control study, with first description of granular-cell trichoblastoma.	23719479
Trichoepithelioma	Stem Cell Exhaustion	PHLDA1 is a follicular stem cell marker, the expression of which has been reported to differentiate trichoepithelioma from BCCs.	23719479
Multiple Sclerosis, Relapsing-Remitting	Stem Cell Exhaustion	T-cell responses after haematopoietic stem cell transplantation for aggressive relapsing-remitting multiple sclerosis.	23721329
MS gene	Stem Cell Exhaustion	Autologous haematopoietic stem cell transplantation (HSCT) for relapsing-remitting multiple sclerosis is a potentially curative treatment, which can give rise to long-term disease remission.	23721329
Pericarditis, CTCAE	Stem Cell Exhaustion	Pericarditis mediated by respiratory syncytial virus in a hematopoietic stem cell transplant patient.	23725410
Pericarditis, CTCAE, Pericardial Effusion, CTCAE, Multiple Myeloma	Stem Cell Exhaustion	We describe a case of pericarditis and large pericardial effusion in a 63-year-old African-American man undergoing autologous hematopoietic stem cell transplant for multiple myeloma.	23725410
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Polymerase chain reaction (PCR)-negative molecular complete remission (mCR) can be induced by stem cell transplantation in some patients with multiple myeloma (MM) and is associated with long-term progression-free survival (PFS).	23727584
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The introduction of autologous stem cell transplantation (SCT) and novel drugs has improved overall survival in multiple myeloma (MM) patients.	23728352
Inappropriate ADH Syndrome	Stem Cell Exhaustion	Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is an important electrolyte abnormality that can occur following allogeneic stem cell transplantation.	23728560
Amyloidosis	Stem Cell Exhaustion	Patients with immunoglobulin light chain amyloidosis who underwent autologous stem cell transplantation between 1995 and 2010 were recruited.	23729727
Proteinuria	Stem Cell Exhaustion	Eligibility criteria included >1 g/dL of proteinuria, dialysis independence at baseline and within the first year of autologous stem cell transplantation, and a minimum follow-up of 1 year.	23729727
Mycoses	Stem Cell Exhaustion	Association between drug tolerability and medical resource use in prophylaxis of invasive fungal infections after allogeneic hematopoietic stem cell transplant.	23730943
Infection	Stem Cell Exhaustion	To conduct a retrospective analysis of the association between drug tolerability and potential economic impact measured by medical resource utilization (MRU) for prophylaxis of invasive antifungal infections (IFI) after allogeneic hematopoietic stem cell transplantation (alloHCT).	23730943
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Occurrence of stem cell defects and of immune-mediated mechanisms was evidenced as relevant for pathophysiology of MDS.	23734938
Lymphoma	Stem Cell Exhaustion	Prognostic factors for survival in lymphoma patients after autologous stem cell transplantation.	23740138
Depression, CTCAE, Degenerative polyarthritis, Cerebrovascular accident	Stem Cell Exhaustion	A prior stroke, macular degeneration, osteoarthritis, and depression, led her to receive intrathecal neural stem cell therapy overseas 1 year before onset of symptoms.	23740462
Dominica, melphalan/prednisone protocol	Stem Cell Exhaustion	Circulating hematopoietic stem and progenitor cell (CHSPCAng) levels were detected at significantly lower concentrations in DM (P < 0.001), whereas levels of seven phenotypically distinct MPs were present at significantly higher concentrations in DM patients and one MP subset was present at significantly lower concentration in DM patients.	23740755
Inflammation, Thrombosis	Stem Cell Exhaustion	This study evaluated a novel high dimensional flow cytometry approach in combination with cytometric fingerprinting (CF), to comprehensively enumerate differentially expressed subsets of pro-angiogenic circulating progenitor cells (CPCs), involved in the repair of vasculature, and microparticles (MPs), frequently involved in inflammation and thrombosis.	23740755
Seizures	Stem Cell Exhaustion	Instead, we determined that the observed mutation distribution fits a germline selection model, where mutant spermatogonial stem cells have a proliferative advantage over unmutated cells.	23740942
Purpura, Thrombotic Thrombocytopenic	Stem Cell Exhaustion	Despite achieving similar CR rates after high-dose therapy/autologous stem cell transplantation vs other MM patients, MGUS-like cases had unprecedented longer time-to-progression (TTP) and overall survival (OS; ~60% at 10 years; P<0.001).	23743858
Electrocardiogram: myocardial infarction (finding), Vascular occlusion	Stem Cell Exhaustion	Endothelial progenitor cells, microvascular obstruction, and left ventricular remodeling in patients with ST elevation myocardial infarction undergoing primary percutaneous coronary intervention.	23746481
Colorectal Carcinoma	Stem Cell Exhaustion	Isolation and phenotypic characterization of colorectal cancer stem cells with organ-specific metastatic potential.	23747337
Specialty Type - cancer	Stem Cell Exhaustion	Migrating cancer stem cells (MCSCs) are believed to form metastases.	23747337
Mycoses	Stem Cell Exhaustion	Risk factors for invasive fungal disease after allogeneic hematopoietic stem cell transplantation: a single center experience.	23747459
Intrinsic Factor Deficiency, Mycoses	Stem Cell Exhaustion	Invasive fungal disease (IFD) is a major cause of morbidity and mortality after hematopoietic stem cell transplantation (HCT).	23747459
Supraventricular arrhythmia	Stem Cell Exhaustion	Incidence of supraventricular arrhythmias during autologous peripheral blood stem cell transplantation.	23747600
Cytomegaloviral colitis, Chronic Active Colitis, Metaplasia, Granuloma, Graft-vs-Host Disease	Stem Cell Exhaustion	These results demonstrate that chronic active colitis with granuloma and Paneth cell metaplasia is not only a specific feature of CCS but also is present in GVHD and CMV colitis, irrespective of stem cell source.	23749110
Toxoplasmosis	Stem Cell Exhaustion	Acute exacerbation of Toxoplasma gondii infection after hematopoietic stem cell transplantation: five case reports among 279 recipients.	23749548
Toxoplasmosis	Stem Cell Exhaustion	Toxoplasmosis is a rare and possibly underestimated complication following hematopoietic stem cell transplantation (HSCT) associated with a high mortality rate, although the incidence of toxoplasmosis after HSCT in Japan has not been established.	23749548
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Plerixafor, a recently approved peripheral blood progenitor cell mobilizing agent, is often added to granulocyte-colony stimulating factor (G-CSF) to mobilize peripheral blood progenitor cells in patients with lymphoma or myeloma who cannot mobilize enough CD34+ cells with G-CSF alone to undergo autologous stem cell transplantation.	23749720
Hematopoietic Stem Cell Mobilization, "HODGKINS AND NON-HODGKINS LYMPHOMA", Multiple Myeloma	Stem Cell Exhaustion	We reviewed the peripheral blood stem cell collection data of 38 consecutive patients with lymphoma (Hodgkin's and non-Hodgkin's) and multiple myeloma who underwent chemomobilization and high-dose G-CSF and just-in-time plerixafor to evaluate the efficacy of this treatment combination.	23749720
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	All patients with multiple myeloma and all but one patient with lymphoma collected the minimum required number of CD34+ cells to proceed with autologous stem cell transplantation (>2 x 10(6) /kg of body weight).	23749720
Malignant Peripheral Nerve Sheath Tumor, Myeloproliferative disease, Neoplasms	Stem Cell Exhaustion	Human myeloproliferative neoplasms (MPNs) are thought to reflect transformation of a hematopoietic stem cell (HSC) and the majority harbor an acquired V617F mutation in the JAK2 tyrosine kinase, making them a paradigm for studying the early stages of tumor establishment and progression.	23750118
JAK2 NP_004963.1:p.V617F	Stem Cell Exhaustion	Self-renewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion.	23750118
Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	Recent descriptions of significant heterogeneity in normal stem cells and cancers have altered our understanding of tumorigenesis, emphasizing the need to understand how single stem cells are subverted to cause tumors.	23750118
Malignant Neoplasms, Hemopoietic stem cell transplant	Stem Cell Exhaustion	Results Of the 1,011 patients, 38.2% had newly diagnosed malignancies, 23.1% were in remission, and 24.9% had received hematopoietic stem-cell transplantations (HSCT, including 145 allogeneic).	23752112
Hematologic Neoplasms	Stem Cell Exhaustion	This retrospective report compared the results of graft source on outcome after allogeneic stem cell transplantation (allo-SCT) in patients with hematologic malignancies receiving a reduced intensity conditioning (RIC) regimen.	23752174
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Autologous peripheral blood stem cell transplantation with granulocyte colony-stimulating factor combined conditioning regimen as a postremission therapy for acute myelogenous leukemia in first complete remission.	23754766
Leukemia, Myelocytic, Acute, Non-M3 Acute Myeloid Leukemia	Stem Cell Exhaustion	We retrospectively analyzed the outcomes of 81 patients with non-M3 acute myelogenous leukemia (AML) in first complete remission (CR1) who were treated with high-dose chemotherapy (HDCT) and autologous peripheral blood stem cell transplantation (Auto-PBSCT) by the Fukuoka Blood and Marrow Transplantation Group between 1989 and 2005.	23754766
Spinal Cord Injuries	Stem Cell Exhaustion	We propose that these cells represent a useful tool both for the in vitro study of differentiation into ventral spinal cord neuronal subtypes, and for examining the potential of conditionally immortalized neural stem cells to facilitate functional recovery after spinal cord injury or disease.	23759128
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Dose-intense etoposide-cyclophosphamide without stem cell transplantation for patients with intermediate and high cytogenetic risk primary refractory and relapsed acute myeloid leukemia.	23759246
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Dose-intense etoposide-cyclophosphamide (D-I ECy) without stem cell transplantation has been used in salvage regimens for the treatment of resistant acute myeloid leukemia(AML).	23759246
Multiple Myeloma	Stem Cell Exhaustion	We present a 58-year-old man with recurrent multiple myeloma treated with 2 autologous stem cell transplantations.	23759296
Aspergillosis	Stem Cell Exhaustion	The serum galactomannan index predicts mortality in hematopoietic stem cell transplant recipients with invasive aspergillosis.	23759343
Immunocompromised Host, Toxoplasmosis, Communicable Diseases	Stem Cell Exhaustion	In immunocompromized patients, including hematopoietic stem cell transplant (HSCT) recipients, life-threatening toxoplasmosis may result from reactivation of previous infection.	23761151
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Migratory activity of circulating progenitor cells and serum SDF-1a predict adverse events in patients with myocardial infarction.	23761401
Ischemic, Acute myocardial infarction	Stem Cell Exhaustion	Following acute myocardial infarction (AMI), pro-angiogenic progenitor cells (PCs) are released from the bone marrow into the circulation and home to the ischaemic site attracted by a chemokine gradient.	23761401
Hepatorenal Syndrome, LIPC gene	Stem Cell Exhaustion	Fifty adult patients with relapsed/refractory HL, adequate marrow reserve, hepatorenal and pulmonary functions, with radiological measurable disease and Karnofsky performance status of 0 - 2 non-candidates for stem cell transplantation, were enrolled.	23763798
Bone Marrow	Stem Cell Exhaustion	Three of these subjects also cleared bone marrow blasts with 1 subsequently proceeding onto successful stem cell transplantation.	23763920
Multiple Myeloma	Stem Cell Exhaustion	Temporal changes in plerixafor administration and hematopoietic stem cell mobilization efficacy: results of a prospective clinical trial in multiple myeloma.	23764455
Childhood Non-Hodgkin Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Plerixafor with granulocyte colony-stimulating factor (G-CSF) is effective for hematopoietic stem cell (HSC) mobilization in patients with non-Hodgkin Lymphoma and myeloma; however, labeling requires dosing 11 hours before apheresis.	23764455
Multiple Myeloma	Stem Cell Exhaustion	To address the effect of afternoon plerixafor dosing on CD34(+) cell yields, we conducted a prospective clinical trial in myeloma patients undergoing stem cell collection.	23764455
B-Cell Lymphomas	Stem Cell Exhaustion	Myeloablative anti-CD20 radioimmunotherapy +/- high-dose chemotherapy followed by autologous stem cell support for relapsed/refractory B-cell lymphoma results in excellent long-term survival.	23765188
Lymphoma	Stem Cell Exhaustion	Myeloablative anti-CD20 RIT followed by autologous stem cell infusion (ASCT) enables high radiation doses to lymphoma sites.	23765188
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A stem cell-like gene expression signature associates with inferior outcomes and a distinct microRNA expression profile in adults with primary cytogenetically normal acute myeloid leukemia.	23765227
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukemia (AML) is hypothesized to be sustained by self-renewing leukemia stem cells (LSCs).	23765227
Multiple Myeloma	Stem Cell Exhaustion	Peripheral blood stem cell mobilization in multiple myeloma patients treat in the novel therapy-era with plerixafor and G-CSF has superior efficacy but significantly higher costs compared to mobilization with low-dose cyclophosphamide and G-CSF.	23765597
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Studies comparing the efficacy and cost of peripheral blood stem and progenitor cells mobilization with low-dose cyclophosphamide (LD-CY) and granulocyte-colony stimulating factor (G-CSF) against plerixafor and G-CSF, in multiple myeloma (MM) patients treated in the novel therapy-era are not available.	23765597
Neoplasms, Hyperplasia	Stem Cell Exhaustion	Impaired mammary cell commitment upon RANK overexpression leads to the accumulation of progenitors including K14+K8+ bipotent cells and the formation of heterogeneous tumors containing hyperplastic basal, luminal, and progenitor cells.	23766243
Adenomatous Polyps	Stem Cell Exhaustion	Individual adenomatous crypts were clonal for mtDNA mutations and contained both mucin-secreting and neuroendocrine cells, demonstrating that the crypt contained a multipotent stem cell.	23766371
Adenoma, Neoplasms	Stem Cell Exhaustion	Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution.	23766371
Adenoma of large intestine	Stem Cell Exhaustion	Here we identify multipotential stem cells within human colorectal adenomas and use methylation patterns of nonexpressed genes to characterize clonal evolution.	23766371
Neoplasms, Adenomatous Polyps	Stem Cell Exhaustion	Adenomatous crypts within human tumors contain actively dividing stem cells.	23766371
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Moreover, they provide a first example that functional variation in a prospective cancer stem cell marker can be associated with disease risk for the corresponding malignancy.	23770371
Lymphoma, Follicular, Lymphoma	Stem Cell Exhaustion	The outcome of reduced intensity allogeneic stem cell transplantation and autologous stem cell transplantation when performed as a first transplant strategy in relapsed follicular lymphoma: an analysis from the Lymphoma Working Party of the EBMT.	23771004
Neoplasms, Hollings Cancer Center	Stem Cell Exhaustion	We performed immunohistochemical staining for uptake transporter of gadoxetic acid: organic anion transporter polypeptides (OATP8); tumor markers: alpha-fetoprotein (AFP) and protein induced by vitamin K absence or antagonist II (PIVKA-II); hepatic stem cell markers: epithelial cell adhesion molecule (EpCAM), cytokeratin 19 (CK19), and neural cell adhesion molecule (NCAM); biliary marker: CK7; hepatocyte marker: hepatocyte paraffin 1 (HepPar1); markers of HCC differentiation: glypican-3; signaling: beta-catenin, and the respective grade was semiquantitatively determined.	23771695
Hollings Cancer Center	Stem Cell Exhaustion	Hyperintense HCC expressed OATP8 and showed a feature of mature hepatocytes with a weak expression of stem cell characteristics immunohistochemically.	23771695
Diabetes	Stem Cell Exhaustion	We demonstrated that expression of miR-21 was elevated in circulating endothelial progenitor cells from diabetes patients.	23771797
EBV-Related Lymphoproliferative Disorder	Stem Cell Exhaustion	Response to rituximab-based therapy and risk factor analysis in Epstein Barr Virus-related lymphoproliferative disorder after hematopoietic stem cell transplant in children and adults: a study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation.	23771985
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	The objective of this analysis was to investigate prognostic factors that influence the outcome of Epstein-Barr virus (EBV)-related posttransplant lymphoproliferative disorder (PTLD) after a rituximab-based treatment in the allogeneic hematopoietic stem cell transplant (HSCT) setting.	23771985
Dyserythropoiesis	Stem Cell Exhaustion	Iron-overload-related dyserythropoiesis and reactive oxygen species (ROS)-related damage to hematopoietic stem cell (HSC) function are major setbacks in treatment for such disorders.	23772810
Wiskott-Aldrich Syndrome, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Successful allogeneic hemopoietic stem cell transplantation in a case of Wiskott-Aldrich syndrome and non-Hodgkin lymphoma.	23773507
Ulcer, Arteriopathic disease	Stem Cell Exhaustion	Moreover, the transplantation of autologous stem cells extracted with Celution may represent a valuable method for the treatment of chronic ulcers in lower limbs of arteriopathic patients.	23773718
Mantle cell lymphoma	Stem Cell Exhaustion	Cytarabine, Ki-67, and SOX11 in patients with mantle cell lymphoma receiving rituximab-containing autologous stem cell transplantation during first remission.	23775587
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	In the current study, the authors report the results of 39 patients with mantle cell lymphoma (MCL) who were treated with chemotherapy and high-dose rituximab-containing autologous stem cell transplantation (ASCT) during their first disease remission.	23775587
Medial collateral ligament	Stem Cell Exhaustion	Administering ASCT with rituximab during stem cell collection and immediately after transplantation may induce a continuous long-term disease remission in patients with MCL with a Ki-67 level of <= 30%.	23775587
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cell (CSC)-associated assays, including expression of self-renewal and CSC marker genes, proliferation, differentiation, spheroid formation, chemotherapy resistance, and tumorigenicity were then conducted between SP and non-SP (NSP) LSCCs.	23776540
Graft-vs-Host Disease, Hematologic Neoplasms	Stem Cell Exhaustion	CD8+ T cell-depleted (TCD) donor lymphocyte infusion (DLI) after TCD allogeneic hematopoietic stem cell transplantation (alloSCT) has been associated with a reduced risk of graft-versus-host disease (GVHD) while preserving conversion to donor hematopoiesis and antitumor immunity, providing a rationale for exploring CD4+ T cell-based immunotherapy for hematologic malignancies.	23777765
Colorectal Carcinoma, Specialty Type - cancer, Secondary Neoplasm, Cytogenetic Complete Response	Stem Cell Exhaustion	Colorectal cancer (CRC) stem cells or tumor-initiating cells (Co-TIC) are implicated in both cancer recurrence and extranodal metastasis.	23777983
Seizures	Stem Cell Exhaustion	Multiple hippocampal transection (MHT) is a new surgical procedure which disrupts seizure propagation within the hippocampus without impairing verbal memory or the loss of stem cells.	23778156
Acute myocardial infarction, Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Effects of ACE inhibition on endothelial progenitor cell mobilization and prognosis after acute myocardial infarction in type 2 diabetic patients.	23778412
Acute myocardial infarction	Stem Cell Exhaustion	We aimed to assess the chemotactic response of endothelial progenitor cells to angiotensin-converting enzyme inhibitors in T2DM patients after acute myocardial infarction, as well as the associated prognosis.	23778412
Opportunistic Infections, Gastrointestinal mucositis	Stem Cell Exhaustion	Oral mucositis is a complication frequently associated with hematopoietic stem cell transplantation, decreasing a patient's quality of life and increasing the occurrence of opportunistic infections.	23778491
Gastrointestinal mucositis	Stem Cell Exhaustion	The purpose of this study was to determine the incidence and severity of oral mucositis and to assess the correlation of this disease with the oral health of an individual at the time of hematopoietic stem cell transplantation.	23778491
Mucositis following radiation therapy	Stem Cell Exhaustion	The incidence of ulcerative mucositis was highest from days +6 to +10 and from days +11 to +15 in the patients who underwent autologous and allogeneic hematopoietic stem cell transplantation, respectively.	23778491
Dental Plaque, Stomatitis	Stem Cell Exhaustion	The data, including the dental plaque and periodontal status data, showed that these oral health factors were predictive of the incidence and severity of oral mucositis in a cohort of patients with similar conditioning regimens before hematopoietic stem cell transplantation.	23778491
Specialty Type - cancer, Primary malignant neoplasm	Stem Cell Exhaustion	The present study investigated whether the expression of CD44 variant 9 (CD44v9), a functional cancer stem cell marker, in the primary gastric cancer tissue represents an indicator of recurrence.	23778530
Neoplasms	Stem Cell Exhaustion	Sustainable complete remission in recurrence yolk sac tumor patient treated with tandem high-dose chemotherapy and autologous stem cell.	23781595
Post-transplant lymphoproliferative disorder, Lymphoproliferative Disorders	Stem Cell Exhaustion	Monitoring of Epstein-Barr virus (EBV) load and pre-emptive rituximab is an appropriate approach to prevent post-transplant lymphoproliferative disease (PTLD) occurring after hematopoietic stem cell transplantation (HSCT).	23781897
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Allogeneic stem cell transplant for adults with myelodysplastic syndromes: relevance of pre-transplant disease status.	23781926
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	The aim of the present study was to investigate the outcome of 94 adult patients with myelodysplasia (MDS) who received an allogeneic stem cell transplant between January 1995 and September 2010 in two Italian hematology centers.	23781926
Specialty Type - cancer	Stem Cell Exhaustion	CK5+ / CK20- cells, a phenotype of cancer stem/progenitor cells, represented a very small population (1.9%) and showed a low proliferation activity.	23782333
Therapy-Related Leukemia, Hypophosphatasia	Stem Cell Exhaustion	Therapy-related Ph+ leukemia after both bone marrow and mesenchymal stem cell transplantation for hypophosphatasia.	23782379
Colorectal Carcinoma	Stem Cell Exhaustion	The leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) is an adult intestinal stem cell marker frequently detected in human colorectal cancers (CRCs).	23784051
Traumatic AND/OR non-traumatic injury	Stem Cell Exhaustion	A 9-year-old boy presented with unilateral, total limbal stem cell deficiency (LSCD) complicated by the presence of a large fibro-vascular ocular surface mass lesion secondary to accidental lime injury.	23784762
Fungal infection of lung	Stem Cell Exhaustion	Aerosolized amphotericin B lipid complex as adjunctive treatment for fungal lung infection in patients with cancer-related immunosuppression and recipients of hematopoietic stem cell transplantation.	23784915
Lung Diseases, Fungal, Toxic effect, Specialty Type - cancer	Stem Cell Exhaustion	Treatment with aeABLC was tolerated without serious toxicity and may be considered in the setting of severe immunosuppression, cancer, and/or hematopoietic stem cell transplantation in patients with difficult-to-treat fungal lung disease.	23784915
Childhood Breast Carcinoma	Stem Cell Exhaustion	Being relatively resistant to conventional treatments, breast cancer stem cells (CSCs) have been postulated as a possible cause of disease recurrence after treatment.	23787917
Coronary Arteriosclerosis	Stem Cell Exhaustion	The combined use of transmyocardial laser revascularisation and intramyocardial injection of bone-marrow derived stem cells in patients with end-stage coronary artery disease: one year follow-up.	23788089
Inflammation	Stem Cell Exhaustion	Angiogenesis may be induced by intramyocardial injection of autologous bone marrow stem cells, intensified by inflammation around channels performed by laser.	23788089
Angina Pectoris	Stem Cell Exhaustion	To assess the effect of a combined treatment consisting of transmyocardial laser revascularisation (TLMR) and intramyocardial injection of bone-marrow derived stem cells (bone marrow laser revascularisation, BMLR) in patients with refractory angina one year after the procedure.	23788089
Cytomegalovirus Retinitis, Multiple Myeloma	Stem Cell Exhaustion	Here, we describe 2 cases of CMV retinitis in myeloma patients with progressive disease, following autologous stem cell transplantation and immunomodulatory therapy for myeloma.	23790037
Graft-vs-Host Disease, Opportunistic Infections	Stem Cell Exhaustion	The efficacy of hematopoietic stem cell transplantation (HSCT) is greatly hampered by graft-versus-host disease (GVHD) and opportunistic infection; the gastrointestinal tract is one of the main target organs involved by GVHD and opportunistic infectious agents.	23791208
Hematologic Neoplasms	Stem Cell Exhaustion	Outcomes in patients age 70 or older undergoing allogeneic hematopoietic stem cell transplantation for hematologic malignancies.	23791626
Hematologic Neoplasms	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HSCT) can achieve durable remissions in a number of patients with advanced hematologic malignancies.	23791626
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Comparison of glioma stem cells to neural stem cells from the adult human brain identifies dysregulated Wnt- signaling and a fingerprint associated with clinical outcome.	23791939
Adult Glioblastoma	Stem Cell Exhaustion	We have performed the first genome-wide analysis that directly relates the gene expression profile of nine enriched populations of glioblastoma stem cells (GSCs) to five identically isolated and cultivated populations of stem cells from the normal adult human brain.	23791939
Specialty Type - cancer	Stem Cell Exhaustion	A subset of these pathways has previously been identified in leukemic stem cells, suggesting that cancer stem cells of different origin may have common features.	23791939
Engraftment syndrome	Stem Cell Exhaustion	Low levels of interleukin-1 receptor antagonist (IL-1RA) predict engraftment syndrome after autologous stem cell transplantation in POEMS syndrome and other plasma cell neoplasms.	23792270
POEMS Syndrome, Engraftment syndrome	Stem Cell Exhaustion	Patients with POEMS are known to have a high incidence of engraftment syndrome after autologous stem cell transplantation.	23792270
Neoplasms	Stem Cell Exhaustion	Biological experiments in GSC cells validated the bioinformatics analysis results and revealed that LGR5 regulated the tumor sphere formation capacity, an important stem cell property for GSCs.	23793848
Hepatitis E, Pathogenesis of HIV Opportunistic Infection	Stem Cell Exhaustion	Hepatitis E virus: an underestimated opportunistic pathogen in recipients of allogeneic hematopoietic stem cell transplantation.	23794068
melanoma, Specialty Type - cancer	Stem Cell Exhaustion	We investigate the unknown tumor-killing activity of cytokine-induced killer (CIK) cells against autologous metastatic melanoma and the elusive subset of putative cancer stem cells (mCSC).	23794732
Lymphomatoid Granulomatosis	Stem Cell Exhaustion	Long-term remission after multiple relapses in an elderly patient with lymphomatoid granulomatosis after rituximab and high-dose cytarabine chemotherapy without stem-cell transplantation.	23796993
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Role of reduced-intensity conditioning allogeneic hematopoietic stem-cell transplantation in older patients with de novo myelodysplastic syndromes: an international collaborative decision analysis.	23797000
Blood Vessel	Stem Cell Exhaustion	Although circulating endothelial progenitor cells (EPCs) preserve endothelial integrity, inflammatory endothelial cells (IECs) detach from sites of injury and represent markers of vascular damage.	23798347
Epithelial ovarian cancer, Secondary Neoplasm	Stem Cell Exhaustion	High levels of circulating CD34+/VEGFR3+ lymphatic/vascular endothelial progenitor cells is correlated with lymph node metastasis in patients with epithelial ovarian cancer.	23803010
Malignant neoplasm of ovary, Secondary Neoplasm	Stem Cell Exhaustion	To clarify the role of CD34 and vascular endothelial growth factor receptor-3-positive (CD34+/VEGFR3+) lymphatic/vascular endothelial progenitor cells (LVEPC) in patients with lymph node metastasis and epithelial ovarian cancer progression, the levels of circulating CD34+/VEGFR3+ LVEPC in epithelial ovarian cancer patients were detected.	23803010
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy (HDT) supported by autologous stem cell transplantation (ASCT) has long been one of the standards of care for younger patients with multiple myeloma (MM).	23804501
Multiple Myeloma	Stem Cell Exhaustion	Hematopoietic progenitor cell mobilization using low-dose cyclophosphamide and granulocyte colony-stimulating factor for multiple myeloma.	23804501
Clostridium difficile colitis, Hematologic Neoplasms	Stem Cell Exhaustion	The primary objective was to assess the incidence and severity of C. difficile infection in patients with hematologic malignancies, including those undergoing hematopoietic stem cell transplant for a hematologic condition.	23804627
Clostridium difficile colitis, Hematologic Neoplasms	Stem Cell Exhaustion	This study is the first analysis conducted, which directly compares outcomes of C. difficile infection after therapy with metronidazole, vancomycin, or combination therapy exclusively in patients with hematologic malignancies, including those undergoing hematopoietic stem cell transplant for a hematologic condition.	23804627
Specialty Type - cancer	Stem Cell Exhaustion	This old agent is now a serious anti-cancer drug candidate that selectively inhibits the growth of cancer stem cells.	23805285
Congestive heart failure, Inflammation	Stem Cell Exhaustion	To determine the effects of physical training on circulating endothelial progenitor cells (EPCs), angiogenesis (angiogenin, angiopoietin-1 and -2, VEGF, Tie-2, SDF-1a) and inflammation (IL-6, CRP), we compared data obtained from 11 CHF pts before and after 3 months aerobic exercise training, to those from 10 non trained CHF pts (CHF-C group, age 64 + 2 years, NYHA 2).	23805979
Engraftment syndrome, Multiple Myeloma	Stem Cell Exhaustion	Divergent effects of novel immunomodulatory agents and cyclophosphamide on the risk of engraftment syndrome after autologous peripheral blood stem cell transplantation for multiple myeloma.	23806770
Engraftment syndrome	Stem Cell Exhaustion	Engraftment syndrome (ES) is an increasingly observed and occasionally fatal complication after autologous peripheral blood stem cell transplantation (PBSCT).	23806770
Aneuploidy	Stem Cell Exhaustion	Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy.	23807220
Specialty Type - cancer	Stem Cell Exhaustion	Patient satisfaction with nutrition services amongst cancer patients treated with autologous stem cell transplantation: a comparison of usual and extended care.	23808817
Specialty Type - cancer	Stem Cell Exhaustion	This study aimed to determine patient satisfaction with clinical nutrition services delivered by an accredited practicing dietitian amongst cancer patients treated with autologous stem cell transplantation that was provided with usual and extended care at 100 days post-transplantation.	23808817
Specialty Type - cancer	Stem Cell Exhaustion	Cancer patients treated with autologous stem cell transplantation were satisfied with usual and extended nutrition care.	23808817
Specialty Type - cancer	Stem Cell Exhaustion	The regenerative effects of fat injections are based on the same hormones, growth factors, and stem cells that stimulate neoplastic angiogenesis and cancer progression in basic research.	23812610
Lymphoma	Stem Cell Exhaustion	Outcomes of patients with relapsed/refractory diffuse large B-cell lymphoma with progression of lymphoma after autologous stem cell transplantation in the rituximab era.	23813874
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Salvage chemotherapy followed by autologous stem cell transplant (ASCT) remains the current standard of care for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) with chemosensitive disease.	23813874
Infection of bloodstream, Hemopoietic stem cell transplant	Stem Cell Exhaustion	[Bloodstream infections after liver and hematopoietic stem cell transplantation].	23814965
Behavioral Symptoms Index Composite Score (BASC-2), Infection of bloodstream	Stem Cell Exhaustion	The aim of this retrospective study was to evaluate and compare the incidence, timing and etiology of bloodstream infections (BSIs) in patients treated with liver-(LT) or hematopoietic stem cell transplantation (HSCT) in a single institution.	23814965
Lymphoma	Stem Cell Exhaustion	Comparision of benefits of early, delayed, and no administration of G-CSF after autologous peripheral blood stem cell transplantation in lymphoma patients.	23817440
Lymphoma	Stem Cell Exhaustion	Autologous peripheral blood stem cell transplantation (PBSCT) is commonly used in the treatment of lymphoma patients.	23817440
Kidney Failure, Rheumatoid Arthritis	Stem Cell Exhaustion	Thymic insufficiency in RA is not attributable to an inadequate supply of progenitor cells to the thymus.	23818218
Osteopenia	Stem Cell Exhaustion	Reversing bone loss by directing mesenchymal stem cells to bone.	23818248
Hodgkin Disease	Stem Cell Exhaustion	Early thymus and activation-regulated chemokine (TARC) reduction and response following panobinostat treatment in patients with relapsed/refractory Hodgkin lymphoma following autologous stem cell transplant.	23822537
Chronic graft-versus-host disease	Stem Cell Exhaustion	National Institutes of Health classification for chronic graft-versus-host disease predicts outcome of allo-hematopoietic stem cell transplant after fludarabine-busulfan-antithymocyte globulin conditioning regimen.	23822538
Stable chronic Graft vs Host Disease, Hematologic Neoplasms	Stem Cell Exhaustion	We retrospectively reclassified cGvHD with NIH criteria in a monocentric cohort of 130 consecutive adult patients with hematological malignancies presenting cGvHD after receiving allo-hematopoietic stem cell transplant (HSCT) with a fludarabine-busulfan-antithymocyte globulin (ATG) conditioning regimen, among 313 consecutive HSCT recipients.	23822538
Diabetes Mellitus, Insulin-Dependent	Stem Cell Exhaustion	Amniotic stem cell transplantation therapy for type 1 diabetes: a case report.	23828649
Diabetes Mellitus, Insulin-Dependent	Stem Cell Exhaustion	A 26-year-old man with type 1 diabetes was treated with stem cells isolated from his neonatal son's amniotic membrane, collected at birth (2 x 10(7) cells).	23828649
B-Cell Lymphomas, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Patients with diffuse large B cell lymphoma (DLBCL) who are not candidates for or recur after autologous stem cell transplant have a poor overall prognosis.	23829878
Chronic Obstructive Airway Disease, Idiopathic Pulmonary Fibrosis	Stem Cell Exhaustion	According to recently proposed pathogenic models in COPD and IPF, premature cellular senescence likely affects distinct progenitors cells (mesenchymal stem cells in COPD, alveolar epithelial precursors in IPF), leading to stem cell exhaustion.	23831269
Hematologic Neoplasms	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell (HSC) transplantation is a curative treatment for many hematologic malignancies for which umbilical cord blood (UCB) represents an alternative source of HSCs.	23831606
B-Cell Lymphomas, Malignant Neoplasms	Stem Cell Exhaustion	Clonal analysis of the hematopoetic stem cell compartment suggests that TET2 mutations can be early events in hematologic cancers and recent investigations have shown TET2 mutations in diffuse large B-cell lymphoma.	23831920
Immunocompromised Host	Stem Cell Exhaustion	To evaluate cell survival and tumorigenicity of human embryonic stem cell-derived retinal pigment epithelium (hESC-RPE) transplantation in immunocompromised nude rats.	23833067
Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Single-agent lenalidomide is active in patients with relapsed or refractory aggressive non-Hodgkin lymphoma who received prior stem cell transplantation.	23834234
Lymphoma, Non-Hodgkin, Familial, Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Patients with aggressive non-Hodgkin lymphoma (NHL) who relapse after autologous stem cell transplantation (ASCT) have a poor prognosis.	23834234
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	The hypothesis on cancer stem cells assumes the existence of small subpopulation of cells that possess the ability to undergo self-renewal and can give rise to the diversity of differentiated cells that form the tumour.	23835592
Childhood Breast Carcinoma	Stem Cell Exhaustion	It has been accepted that CD44(+)/CD24(-/low) phenotype is one of the features characterizing breast cancer stem cells.	23835592
Neoplasms	Stem Cell Exhaustion	GBM is a highly heterogeneous tumour and may contain different stem cell populations with different functional properties.	23836332
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Increasing evidence shows that brain tumours contain the population of stem cells, so-called cancer stem cells (CSCs).	23836332
Acute Promyelocytic Leukemia	Stem Cell Exhaustion	Role of hematopoietic stem cell transplantation for relapsed acute promyelocytic leukemia: a retrospective analysis of JALSG-APL97.	23837667
ATRICHIA WITH PAPULAR LESIONS	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) during CR2 might be effective, but data on the role of HSCT for APL patients after CR2 are limited in Japan.	23837667
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Targeting insulin resistance in type 2 diabetes via immune modulation of cord blood-derived multipotent stem cells (CB-SCs) in stem cell educator therapy: phase I/II clinical trial.	23837842
Inflammation, Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Clinical findings indicate that T2D patients achieve improved metabolic control and reduced inflammation markers after receiving Stem Cell Educator therapy.	23837842
Immune System Diseases	Stem Cell Exhaustion	Mechanistic studies revealed that Stem Cell Educator therapy reverses immune dysfunctions through immune modulation on monocytes and balancing Th1/Th2/Th3 cytokine production.	23837842
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Clinical data from the current phase 1/phase 2 study demonstrate that Stem Cell Educator therapy is a safe approach that produces lasting improvement in metabolic control for individuals with moderate or severe T2D who receive a single treatment.	23837842
Acute GVH disease	Stem Cell Exhaustion	Proteomic peptide profiling for preemptive diagnosis of acute graft-versus-host disease after allogeneic stem cell transplantation.	23842427
Graft-vs-Host Disease, Hematologic Neoplasms, Acute GVH disease	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation is one curative treatment for hematological malignancies, but is compromised by life-threatening complications, such as severe acute graft-versus-host disease (aGvHD).	23842427
Cartilage Diseases	Stem Cell Exhaustion	Increasing evidence indicates that the secretome of mesenchymal stem cells (MSCs) has therapeutic potential for the treatment of various diseases, including cartilage disorders.	23843355
Neutropenia	Stem Cell Exhaustion	The results indicated that granulocyte colony stimulating factor (G-CSF) enhanced survival, stimulated recovery from neutropenia, and induced mobilization of hematopoietic progenitor cells.	23845847
Stem Cell Factor, Childhood Breast Carcinoma, Neoplasms, Mammary Neoplasms, Carcinoma	Stem Cell Exhaustion	Plasma levels of selected hematopoietic cytokines: interleukin 3 ( IL-3), stem cell factor (SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF) and macrophage colony-stimulating factor (M-CSF), and the tumor marker carcinoma antigen 15-3 (CA 15-3) in breast cancer (BC) patients were investigated and compared to control groups: benign breast tumor patients and healthy subjects.	23846151
PAFAH1B1 wt Allele	Stem Cell Exhaustion	In patients with MDS, MRD remains the best stem cell source followed by 8 of 8 MUD.	23847196
T-Cell Lymphoma	Stem Cell Exhaustion	Allogeneic stem cell transplantation with BEAM and alemtuzumab conditioning immediately after remission induction has curative potential in advanced T-cell non-Hodgkin's lymphoma.	23850653
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Patients with relapsed or refractory advanced T cell non-Hodgkin lymphoma have a dismal prognosis and may not even reach allogeneic hematopoietic stem cell transplantation (HSCT) in adequate condition.	23850653
Osteolipoma	Stem Cell Exhaustion	Mesenchymal stem cells in adipose tissue that have potential to differentiate into fat, bone, cartilage, and vascular components may be involved in the development of osteolipoma, in which adipose and bone tissues coexist.	23851795
Lipoma	Stem Cell Exhaustion	Mesenchymal stem cells were collected by collagenase treatment of lipoma tissue, and their potential to differentiate into fat, bone, and cartilage was shown.	23851795
Osteolipoma	Stem Cell Exhaustion	On the basis of this study, we suggest that lipoma-derived mesenchymal stem cells are the basis of the pathogenesis of osteolipoma.	23851795
MYELODYSPLASTIC SYNDROME, Multiple Myeloma	Stem Cell Exhaustion	Hematopoietic progenitor cell collection after autologous transplant for multiple myeloma: low platelet count predicts for poor collection and sole use of resulting graft enhances risk of myelodysplasia.	23852547
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Collection of hematopoietic progenitor cells (HPC) after previous autologous hematopoietic progenitor cell transplant (aHCT) was studied in 221 patients with multiple myeloma (MM).	23852547
Idiopathic Pulmonary Fibrosis, Chronic lung disease	Stem Cell Exhaustion	Regenerative medicine and particular adult stem cells represent an alternative option with several fruitful therapeutic applications in patients suffering from chronic lung diseases including idiopathic pulmonary fibrosis (IPF).	23855653
Hollings Cancer Center	Stem Cell Exhaustion	Immunohistochemistry was used to localize phosphorylated c-kit (CD117/stem cell factor) in HCC smooth muscle cells.	23856589
Aspergillosis	Stem Cell Exhaustion	TLR5 stop codon polymorphism is associated with invasive aspergillosis after allogeneic stem cell transplantation.	23862689
Aspergillosis	Stem Cell Exhaustion	Single nucleotide polymorphisms (SNPs) have been associated with an increased incidence of invasive aspergillosis (IA) after allogeneic stem cell transplantation (allo-SCT).	23862689
Multiple Myeloma	Stem Cell Exhaustion	Implications of continued response after autologous stem cell transplantation for multiple myeloma.	23863899
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Patients undergoing autologous stem cell transplantation (ASCT) for multiple myeloma (MM) undergo disease assessment approximately 100 days later.	23863899
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	AML patients (n = 14) with a median age of 46 years received 7+3 courses (n = 3) containing cytarabine > or = 1 g/m2/introduction (n = 8) and myeloablative conditioning regimen before hematopoietic stem cell transplantation (n = 3).	23866600
Colitis	Stem Cell Exhaustion	Antioxidant properties of mesalamine in colitis inhibit phosphoinositide 3-kinase signaling in progenitor cells.	23867870
Mastocytosis	Stem Cell Exhaustion	Migration of CD117+ progenitor cells from the blood was enhanced toward NGF-b gradient in both mastocytosis and controls.	23869086
diabetic	Stem Cell Exhaustion	Human immune system development and survival of non-obese diabetic (NOD)-scid IL2rg(null) (NSG) mice engrafted with human thymus and autologous haematopoietic stem cells.	23869841
Hypoplastic Left Heart Syndrome	Stem Cell Exhaustion	Fetal reprogramming and senescence in hypoplastic left heart syndrome and in human pluripotent stem cells during cardiac differentiation.	23871585
Hypoxia	Stem Cell Exhaustion	We recapitulated the fetal phenotype by subjecting human pluripotent stem cells to hypoxia during cardiac differentiation.	23871585
Hypoxia	Stem Cell Exhaustion	The phenotype is recapitulated by subjecting human pluripotent stem cells to hypoxia during cardiac differentiation and rescued by inhibition of TGF-b1.	23871585
Multiple Myeloma	Stem Cell Exhaustion	A randomized phase II trial of fludarabine/melphalan 100 versus fludarabine/melphalan 140 followed by allogeneic hematopoietic stem cell transplantation for patients with multiple myeloma.	23872222
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (allo-HCT) is a potentially curative treatment for multiple myeloma (MM); however, because of high treatment-related mortality (TRM), its role is not well defined.	23872222
Crohn Disease	Stem Cell Exhaustion	Transplantation of peripheral blood stem cells has been successful therapy for small numbers of patients with Crohn's disease (CD), but requires prior myeloconditioning.	23872668
Malignant Neoplasms	Stem Cell Exhaustion	Controls were matched for timing relative to transplant, malignancy, and stem cell source.	23872740
Membranoproliferative Glomerulonephritis, Type II	Stem Cell Exhaustion	The patient experienced marked improvement of muscle strength after autologous stem cell transplantation and treatment with bortezomib, a therapy that is known to be effective in light chain deposition disease.	23873431
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	The management of patients with mantle cell lymphoma (MCL) not eligible for stem cell transplantation in relapse after receiving standard approaches remains challenging, and the search for active and tolerable regimens is still warranted.	23873598
Anemia	Stem Cell Exhaustion	Efforts to understand the pathophysiology of anemia in this population, especially the one third of patients with "unexplained" anemia, have focused on the potential contributions of inflammatory pathways, erythropoietin resistance, and changes in hematopoietic stem cells to the age-dependent decrease in red cell mass.	23874029
Specialty Type - cancer, Krukenberg Tumor	Stem Cell Exhaustion	Furthermore, we examined the expression of some cancer stem cells (CSCs) markers or related molecules in 64 ovarian metastases specimens and analyzed the correlation between these molecules and patients' survival.	23874550
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Peri-procedural tight glycemic control during early percutaneous coronary intervention up-regulates endothelial progenitor cell level and differentiation during acute ST-elevation myocardial infarction: effects on myocardial salvage.	23876463
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	We examined the effects of peri-procedural intensive glycemic control during early percutaneous coronary intervention (PCI) on the number and differentiation of endothelial progenitor cells (EPCs) and myocardial salvage (MS) in hyperglycemic patients with first ST-elevation myocardial infarction (STEMI).	23876463
Multiple Myeloma	Stem Cell Exhaustion	Combination of high-dose melphalan and bortezomib as conditioning regimen for autologous peripheral blood stem cell transplantation in multiple myeloma.	23877150
Toxic effect	Stem Cell Exhaustion	Engraftment of autologous peripheral blood stem cells and regimen-related toxicities (RRT) were comparable among the HDM and Bor-HDM groups.	23877150
Non-Small Cell Lung Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Baseline and post-surgery endothelial progenitor cell levels in patients with early-stage non-small-cell lung carcinoma: impact on cancer recurrence and survival.	23882070
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Results of clonogeneic progenitor cell assays from 52 patients with newly diagnosed CML were correlated with disease characteristics at presentation and molecular response to imatinib.	23883175
Neoplasms, Intracranial	Stem Cell Exhaustion	Neural stem cell sparing by linac based intensity modulated stereotactic radiotherapy in intracranial tumors.	23883368
Neoplasms, Intracranial	Stem Cell Exhaustion	The feasibility of neural stem cell niches sparing with sophisticated linac based inverse IMSRT with 7 beamlets in an unselected cohort of intracranial tumors in relation to topographic situation has been demonstrated.	23883368
Imprinting (Psychology)	Stem Cell Exhaustion	It can be hypothesized that skeletal muscle microenvironmental changes induced by endurance training lead to metabolic imprinting on myogenic progenitor cells.	23884778
Radiation Pneumonitis	Stem Cell Exhaustion	Variations of circulating endothelial progenitor cells and transforming growth factor-beta-1 (TGF-b1) during thoracic radiotherapy are predictive for radiation pneumonitis.	23885707
Retinitis Pigmentosa, Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	This study investigated the variations of circulating endothelial progenitor cells (EPCs) and transforming growth factor-beta-1 (TGF-b1) during three-dimensional conformal radiation therapy (3D-CRT) in patients with non-small-cell lung cancer (NSCLC) and analyzed the correlation between these variations with the occurrence of RP.	23885707
Neoplasms	Stem Cell Exhaustion	For each patient, frozen normal and tumor tissue was used for the comparison of gene expression levels of two putative cancer stem cell markers, CDX2 and Oct4, using real-time PCR (rtPCR).	23887079
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Glioma spheroids obtained via ultrasonic aspiration are viable and express stem cell markers: a new tissue resource for glioma research.	23887192
Mycoses, Aspergillosis	Stem Cell Exhaustion	Posaconazole is recommended for prophylaxis of fungal infections and for salvage therapy of invasive aspergillosis after stem cell transplantation.	23890126
Illness (finding), Respiratory Tract Infections	Stem Cell Exhaustion	Human rhinoviruses (HRVs) are a common cause of upper respiratory infection (URI) in hematopoietic stem cell transplant (HSCT) recipients; yet, their role in lower respiratory illness is not well understood.	23890179
Aspergillosis	Stem Cell Exhaustion	Increased susceptibility for aspergillosis and post-transplant immune deficiency in patients with gene variants of TLR4 after stem cell transplantation.	23890253
Opportunistic fungal infection, Immunocompromised Host	Stem Cell Exhaustion	In allogeneic hematopoietic stem cell transplantation (HSCT), the frequent opportunistic fungal infections remain an important cause of mortality and morbidity in these highly immunocompromised patients.	23890253
Influenza due to Influenza A virus subtype H1N1	Stem Cell Exhaustion	A multicenter evaluation of pandemic influenza A/H1N1 in hematopoietic stem cell transplant recipients.	23890293
Viral respiratory infection	Stem Cell Exhaustion	Hematopoietic stem cell transplant (HSCT) recipients have increased morbidity from respiratory viral infections.	23890293
Infection	Stem Cell Exhaustion	Treatment with allogeneic virus-specific cytotoxic T lymphocytes from seropositive third-party donors may be a feasible therapeutic option for infections following cord-blood stem cell transplantation or hematopoietic stem cell transplantation from virus-seronegative donors.	23891747
Primary, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In order to evaluate the significance of the GABARAPs in the pathogenesis of acute myeloid leukemia (AML), we compared their expression in primary AML patient samples, CD34(+) progenitor cells and in granulocytes from healthy donors.	23891751
Graft-vs-Host Disease	Stem Cell Exhaustion	We report a patient with entrapment syndromes of multiple nerves associated with chronic graft-versus-host-disease (GVHD) after allogeneic hematopoietic stem cell transplantation.	23893492
Allogeneic Hematopoietic Stem Cell Transplantation, Herpes Simplex Infections	Stem Cell Exhaustion	Low-dose acyclovir prophylaxis for the prevention of herpes simplex virus disease after allogeneic hematopoietic stem cell transplantation.	23895431
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents.	23896410
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Importantly, dasatinib markedly increases the elimination of AML stem cells capable of engrafting immunodeficient mice by chemotherapeutic agents.	23896410
Palmar-plantar erythrodysesthesia syndrome, leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In vivo dasatinib treatment enhances chemotherapy-induced targeting of primary murine AML stem cells capable of regenerating leukemia in secondary recipients.	23896410
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Combined treatment using dasatinib and chemotherapy provides a novel approach to increasing p53 activity and enhancing targeting of AML stem cells.	23896410
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Treatment with the SFK and c-KIT inhibitor dasatinib selectively inhibits human AML stem/progenitor cell growth in vitro.	23896410
FGR gene, HCK gene, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We show here that the SFKs LYN, HCK, or FGR are overexpressed and activated in AML progenitor cells.	23896410
Acute leukemia	Stem Cell Exhaustion	Predictive factors for rapid neutrophil and platelet engraftment after allogenic peripheral blood stem cell transplantation in patients with acute leukemia.	23896629
Acute leukemia	Stem Cell Exhaustion	The aim of this study was to investigate predictive factors for rapid engraftment after allogeneic peripheral blood stem cell transplantation (alloPBSCT) in patients with acute leukemia.	23896629
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Dysfunction of endothelial progenitor cells from smokers and chronic obstructive pulmonary disease patients due to increased DNA damage and senescence.	23897750
Multiple Myeloma	Stem Cell Exhaustion	Bortezomib-based versus nonbortezomib-based induction treatment before autologous stem-cell transplantation in patients with previously untreated multiple myeloma: a meta-analysis of phase III randomized, controlled trials.	23897961
Multiple Myeloma	Stem Cell Exhaustion	Varicella-zoster virus-associated fulminant hepatitis following allogeneic hematopoietic stem cell transplantation for multiple myeloma.	23903507
herpesvirus 3, human, Communicable Diseases	Stem Cell Exhaustion	Disseminated visceral varicella-zoster virus (VZV) infection rarely occurs in recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT).	23903507
Specialty Type - cancer	Stem Cell Exhaustion	The discovery of specific membrane-associated cancer stem cell (CSC) markers is crucial for the development of novel therapeutic strategies to target these CSCs.	23903875
Bacteremia, Gastrointestinal mucositis, Neutropenia	Stem Cell Exhaustion	This case underscores that mostly nonpathogenic N. mucosa can cause bacteremia in neutropenic patients who developed mucositis after hematopoietic stem cell transplantation.	23905778
Neoplasms	Stem Cell Exhaustion	Efficacious therapy requires the removal of stem-cell like cells, these cells drive tumor progression because of their ability to self-renew and differentiate.	23907517
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	The efficacy and safety of plerixafor + G-CSF in enhancing hematopoietic stem cell mobilization and collection has been demonstrated in two phase III studies involving patients with NHL or MM.	23907769
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	The proportion of older patients who achieved target stem cell yields was significantly higher in the plerixafor group than in placebo group (NHL: 50.9 vs. 25.4%, P < 0.001; MM: 69.6 vs. 23.7%, P < 0.001).	23907769
Lymphoma, Non-Hodgkin, Multiple Myeloma	Stem Cell Exhaustion	Safety and efficacy of upfront plerixafor + G-CSF versus placebo + G-CSF for mobilization of CD34(+) hematopoietic progenitor cells in patients >=60 and <60 years of age with non-Hodgkin's lymphoma or multiple myeloma.	23907769
HIV, Malignant Neoplasms	Stem Cell Exhaustion	In a randomized, double-blind, placebo-controlled, multicenter study, 4 doses ZVHT or placebo were administered approximately 30 days apart to adults with either solid tumor malignancy (STM); hematologic malignancy (HM); human immunodeficiency virus (HIV) with CD4(+) <=200; autologous hematopoietic stem-cell transplant (HCT) or allogeneic-HCT recipients.	23908479
Multiple Myeloma	Stem Cell Exhaustion	Fifteen years of single center experience with stem cell transplantation for multiple myeloma: a retrospective analysis.	23909048
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) became standard of care for patients with multiple myeloma (MM) under the age of 65 years.	23909048
Central neuroblastoma	Stem Cell Exhaustion	He required intensive chemotherapy with polypharmacy, followed by cord blood stem cell transplantation to treat the neuroblastoma.	23910817
Addisonian crisis	Stem Cell Exhaustion	Continuous hydrocortisone therapy is feasible for preventing adrenal crisis and this report may provide an effective management for hydrocortisone replacement in 21-hydroxylase-deficient patients undergoing chemotherapy and hematopoietic stem cell transplantation.	23910817
Specialty Type - cancer	Stem Cell Exhaustion	Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression.	23911321
Specialty Type - cancer	Stem Cell Exhaustion	Strikingly, we discovered a critical function of Skp2 in positively regulating cancer stem cell populations and self-renewal ability through genetic and pharmacological approaches.	23911321
Specialty Type - cancer	Stem Cell Exhaustion	Our study thus provides pharmacological evidence that Skp2 is a promising target for restricting cancer stem cell and cancer progression.	23911321
SERPINB3 wt Allele, Specialty Type - cancer	Stem Cell Exhaustion	The objective of this study to determine protein expression of cancer stem cell marker CD133 in tissue samples of patients with OLP and evaluate the correlation between CD133 expression and the risk of progression to OSCC.	23911820
Hematologic Neoplasms	Stem Cell Exhaustion	Patients with advanced hematologic malignancies remain at risk for relapse following reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (allo-HSCT).	23912587
Stable chronic Graft vs Host Disease	Stem Cell Exhaustion	On multivariate analysis, use of BM as stem cell source was associated with better OS and EFS, and less acute and cGVHD; young age was associated with better EFS and lower risk of graft failure.	23912664
Hair follicle structure	Stem Cell Exhaustion	The leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5), also known as Gpr49, has been identified as a marker of crypt basal columnar stem cells along the gastrointestinal tract and of bulge stem cells in the hair follicle.	23915911
Specialty Type - cancer	Stem Cell Exhaustion	The enzyme aldehyde dehydrogenase 1 (ALDH1) has been reported as a biomarker for identifying cancer stem cells.	23916993
Leukoencephalopathy, Progressive Multifocal, Chronic Lymphocytic Leukemia, Leukoencephalopathy	Stem Cell Exhaustion	We describe a case of progressive multifocal leucoencephalopathy (PML) in a 39-year-old patient diagnosed with chronic lymphocytic leukaemia (CLL) who underwent two allogenic matched-sibling stem cell transplantations.	23917368
Neurologic Symptoms, Virus Diseases	Stem Cell Exhaustion	However, after the second stem cell transplantation, new neurological symptoms began and a reactivation of the JC virus infection was detected.	23917368
Pulmonary Embolism	Stem Cell Exhaustion	Familial occurrence of pulmonary embolism after intravenous, adipose tissue-derived stem cell therapy.	23918585
Disk, Herniated	Stem Cell Exhaustion	He had received intravenous autologous adipose tissue-derived stem cell therapy for cervical herniated intervertebral disc three times (one, two, and three months prior to the visit).	23918585
Acute leukemia	Stem Cell Exhaustion	Second allograft for hematologic relapse of acute leukemia after first allogeneic stem-cell transplantation from related and unrelated donors: the role of donor change.	23918951
Acute leukemia	Stem Cell Exhaustion	To evaluate the role of a second allogeneic hematopoietic stem-cell transplantation (HSCT2) given for relapsed acute leukemia (AL) after related or unrelated first hematopoietic stem-cell transplantation (HSCT1) and to analyze the role of donor change for HSCT2 in both settings.	23918951
Lymphoma, Follicular	Stem Cell Exhaustion	Stem cell transplantation for follicular lymphoma relapsed/refractory after prior rituximab: a comprehensive analysis from the NCCN lymphoma outcomes project.	23921646
Lymphoma, Follicular	Stem Cell Exhaustion	Stem cell transplant (SCT)-related outcomes and prognostication for relapsed/refractory follicular lymphoma (FL) are not well-defined in the post-rituximab era.	23921646
Specialty Type - cancer	Stem Cell Exhaustion	The mRNA and protein levels of Pyk2 or cancer stem cell markers (ALDH1a1, ABCG2 and Bmi-1) were either examined by reverse transcription-PCR or western blotting.	23922106
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Cost-effectiveness of hematopoietic stem cell mobilization strategies including plerixafor in multiple myeloma and lymphoma patients.	23922227
Mesenchymal Stem Cells, Thrombocytopenia due to platelet alloimmunization	Stem Cell Exhaustion	Thalidomide corrects impaired mesenchymal stem cell function in inducing tolerogenic DCs in patients with immune thrombocytopenia.	23926306
Inosine Triphosphate, Decreased platelet count, Autoimmune Disorder, CTCAE	Stem Cell Exhaustion	Immune thrombocytopenia (ITP) is an autoimmune disorder in which impaired mesenchymal stem cells (MSCs) are potentially involved.	23926306
Congestive heart failure	Stem Cell Exhaustion	This cohort formed the sampling frame for selecting controls (without CHF) matched on: age, race/ethnicity, cumulative anthracycline exposure, stem cell source (allogeneic, autologous), and length of follow-up.	23927520
Osteoporotic Fractures	Stem Cell Exhaustion	Cyclic tensile strain enhances osteogenesis and angiogenesis in mesenchymal stem cells from osteoporotic donors.	23927731
Acute leukemia	Stem Cell Exhaustion	Feasibility of clofarabine cytoreduction followed by haploidentical hematopoietic stem cell transplantation in patients with relapsed or refractory advanced acute leukemia.	23928857
Acute leukemia	Stem Cell Exhaustion	This retrospective study was performed to evaluate the feasibility and anti-leukemic activity of a sequential therapy using clofarabine for cytoreduction followed by conditioning for haploidentical hematopoietic stem cell transplantation (HSCT) in patients with non-remission acute leukemia.	23928857
Specialty Type - cancer	Stem Cell Exhaustion	Embryogenesis, morphogens and cancer stem cells: putting the puzzle together.	23932050
Specialty Type - cancer, Carcinogenesis	Stem Cell Exhaustion	This paper describes a model which puts together three key elements of cancer theory: the analogies between embryogenesis and carcinogenesis, the role played in both processes by morphogens and related pathways, and the recently emerged paradigm of cancer stem cells.	23932050
Specialty Type - cancer	Stem Cell Exhaustion	Our hypothesis also suggests that cancer stem cells can stay dormant until they are activated in a process that resembles activation of stem cells during tissue repair or at a specific time during development.	23932050
PAFAH1B1 wt Allele, Multiple Myeloma	Stem Cell Exhaustion	Prevalence of iron overload vs iron deficiency in multiple myeloma: resembling or different from MDS--and stem cell transplant (SCT)--patients?	23932905
Hematopoietic stem cells, Paroxysmal nocturnal hemoglobinuria, Hemolysis (biological function), Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, progressive hematopoietic stem cell disorder characterized by chronic complement-mediated hemolysis leading to life-threatening complications and early mortality.	23934275
Malignant Neoplasms	Stem Cell Exhaustion	Alternative donor hematopoietic stem cell transplantation for mature lymphoid malignancies after reduced-intensity conditioning regimen: similar outcomes with umbilical cord blood and unrelated donor peripheral blood.	23935024
Chronic graft-versus-host disease	Stem Cell Exhaustion	In a multivariate analysis, no differences were observed in the outcomes between the two stem cell sources except for a higher risk of neutrophil engraftment (hazard ratio=2.12; P<0.0001) and chronic graft-versus-host disease (hazard ratio 2.10; P=0.0002) after matched unrelated donor transplant.	23935024
Malignant Neoplasms	Stem Cell Exhaustion	We studied 645 adult patients with mature lymphoid malignancies who received an allogeneic unrelated donor transplant using umbilical cord blood (n=104) or mobilized peripheral blood stem cells (n=541) after a reduced-intensity conditioning regimen.	23935024
Gaucher Disease, Type 1	Stem Cell Exhaustion	A prospective study of bone marrow hematopoietic and mesenchymal stem cells in type 1 Gaucher disease patients.	23935976
Small Nuclear Ribonucleoprotein Polypeptide F	Stem Cell Exhaustion	In 15 cases of KSs diagnosed during 2000-2011, the clinicopathological features were correlated with the immunoexpression of c-Kit, SMA, CD34, CD31, vascular endothelial growth factor (VEGF), COX-2, c-KIT, smooth muscle antigen (SMA), and stem cell surface marker CD105.	23936513
leukemia, Leukemia, Myelocytic, Acute, Chromosome Aberrations	Stem Cell Exhaustion	The recognition of specific cytogenetic abnormalities present in FA known to predispose to AML is crucial for early haematopoietic stem cell transplant (HSCT) before transformation to leukemia.	23937881
Transplant-Related Malignant Neoplasm, Malnutrition	Stem Cell Exhaustion	Allogeneic haematopoietic stem-cell transplantation (allo-HSCT) is associated with frequent and severe malnutrition, which may contribute to transplant-related morbidity.	23938114
Multiple Myeloma	Stem Cell Exhaustion	The impact of novel drugs for treating multiple myeloma (MM) on the utilization and outcomes of autologous hematopoietic progenitor cell transplantation (AHPCT) is unknown.	23939198
Malignant tumor of colon	Stem Cell Exhaustion	This paper reports the case of a patient with an advanced colonic cancer in the era of stem cell therapy.	23941680
Specialty Type - cancer	Stem Cell Exhaustion	Healing stories: narrative characteristics in cancer survivorship narratives and psychological health among hematopoietic stem cell transplant survivors.	23942197
Depression, CTCAE, Illness (finding), Anxiety Disorders	Stem Cell Exhaustion	Survivors of hematopoietic stem cell transplant (HSCT) have experienced a life threatening and potentially traumatic illness and treatment that make them vulnerable to long lasting negative psychological outcomes, including anxiety and depression.	23942197
Mantle cell lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation in mantle cell lymphoma: a report from the SFGM-TC.	23949376
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) is considered as an attractive treatment option for young mantle cell lymphoma (MCL) patients.	23949376
Specialty Type - cancer, Carcinogenesis	Stem Cell Exhaustion	Cancer stem cells biomarkers in gastric carcinogenesis.	23949555
Specialty Type - cancer, Carcinogenesis	Stem Cell Exhaustion	Gastric carcinogenesis is a multistep process, involving multiple molecular alterations, including changes in cancer stem cells (CSCs).	23949555
Specialty Type - cancer, Carcinogenesis	Stem Cell Exhaustion	The present investigation was undertaken to determine whether changes in cancer stem cells could be utilized as a marker of progression of gastric carcinogenesis by examining the expression of gastric CSCs at different stages of carcinogenesis.	23949555
Blood Coagulation Disorders	Stem Cell Exhaustion	Effect of recombinant human soluble thrombomodulin on clinical outcomes of patients with coagulopathy after hematopoietic stem cell transplantation.	23952647
Rhabdomyosarcoma, Hemorrhagic cystitis, Aplastic Anemia, Acute leukemia	Stem Cell Exhaustion	On univariate analysis increased risk of hemorrhagic cystitis was significantly associated with age greater than 5 years, male gender, cyclophosphamide or busulfan chemotherapy, bone marrow or peripheral blood stem cell transplantation, pelvic radiotherapy and underlying diagnoses of rhabdomyosarcoma, acute leukemia and aplastic anemia.	23954584
Hemorrhagic cystitis	Stem Cell Exhaustion	On multivariate analysis age greater than 5 years, allogeneic bone marrow or peripheral blood stem cell transplantation and pelvic radiotherapy were significantly associated with increased risk of hemorrhagic cystitis.	23954584
Hemorrhagic cystitis	Stem Cell Exhaustion	Older age, late onset hemorrhagic cystitis, positive urine culture for BK virus and bone marrow or peripheral blood stem cell transplantation were associated with greater disease severity.	23954584
Hemorrhagic cystitis	Stem Cell Exhaustion	Older age, previous bone marrow or peripheral blood stem cell transplantation and BK virus in the urine are risk factors for hemorrhagic cystitis and are associated with a higher severity score.	23954584
Retinal defect	Stem Cell Exhaustion	Surgically induced periosteal membrane holds great potential for the treatment of large bone defects representing a simple alternative to combinations of exogenous stem cells, scaffolds and growth factors.	23954755
B-Cell Lymphomas, Chemosensitivity, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Patients with relapsed or refractory diffuse large B cell lymphoma (DLBCL) are treated with salvage regimens and may be considered for high-dose chemotherapy and autologous stem cell transplantation if disease is chemosensitive.	23955074
Keratosis	Stem Cell Exhaustion	Precancerous actinic keratoses (AKs) (17) and SCCs (27) expressed two telomere phenotypes: (i) tissue-wide evenly short to intermediate and (ii) longer and tissue-wide heterogeneous telomere lengths, suggesting two modes of initiation, with one likely to originate in the epidermal stem cells.	23955078
Thrombus, Idiopathic pneumonia syndrome	Stem Cell Exhaustion	Idiopathic pneumonia syndrome with thrombotic microangiopathy-related changes after allogeneic hematopoietic stem cell transplantation.	23955112
Idiopathic pneumonia syndrome, Alveolar	Stem Cell Exhaustion	Idiopathic pneumonia syndrome (IPS), defined as widespread alveolar injury, is a severe complication of hematopoietic stem cell transplantation (HSCT) and a clinical syndrome with variable histopathologic correlates and multiple etiologies.	23955112
Experimental Organism Malignant Hepatocholangiocellular Carcinoma	Stem Cell Exhaustion	Clinicopathologic significance of combined hepatocellular-cholangiocarcinoma with stem cell subtype components with reference to the expression of putative stem cell markers.	23955451
Experimental Organism Malignant Hepatocholangiocellular Carcinoma	Stem Cell Exhaustion	To examine the clinicopathologic features of combined hepatocellular-cholangiocarcinoma (HC-CC), which the World Health Organization (WHO) proposed classifying into 2 types, and the expression of delta-like 1 homolog (DLK1), as well as putative stem cell markers, such as NCAM/CD56 and CD133.	23955451
Malignant neoplasm of liver	Stem Cell Exhaustion	The 2010 WHO classification seems important for elucidating the pathogenesis of stem cell-related liver cancers.	23955451
Coinfection	Stem Cell Exhaustion	Co-infections with cytomegalovirus and human herpesvirus type 7 in adult Polish allogeneic haematopoietic stem cell transplant recipients.	23955532
Communicable Diseases	Stem Cell Exhaustion	Human herpesvirus 7 (HHV-7) is widespread around the world and may also be a possible cofactor for cytomegalovirus (CMV) infection in haematopoietic stem cell transplant (HSCT) recipients.	23955532
Thalassemia	Stem Cell Exhaustion	Long-term health-related quality of life evaluated more than 20 years after hematopoietic stem cell transplantation for thalassemia.	23958950
Infection	Stem Cell Exhaustion	Cytomegalovirus (CMV) infections continue to cause significant morbidity and mortality in hematopoietic stem cell transplant (HSCT) recipients.	23959787
Myeloma kidney, Multiple Myeloma	Stem Cell Exhaustion	Safety and efficacy of autologous hemopoietic progenitor cell collection in tandem with hemodialysis in multiple myeloma with myeloma cast nephropathy.	23959911
Multiple Myeloma	Stem Cell Exhaustion	Autologous hemopoietic progenitor cell (HPC) collection is the most frequent indication for an apheresis procedure in patients with multiple myeloma, up to 10% of whom may also require hemodialysis because of myeloma kidney.	23959911
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	We assessed the prevalence and clinical features of genital skin changes in men after allogeneic hematopoietic stem cell transplantation (HSCT) and evaluated the correlation between genital chronic graft-versus-host disease (cGVHD) and other manifestations of cGVHD as well as sexual issues.	23962394
Adult Glioblastoma, Neoplasms	Stem Cell Exhaustion	Suberoylanilide hydroxamic acid (SAHA) causes tumor growth slowdown and triggers autophagy in glioblastoma stem cells.	23962875
Adult Glioblastoma	Stem Cell Exhaustion	Here, we report that SAHA specifically triggers autophagy and reduces cell viability via promotion of apoptosis in the late phase of glioblastoma stem cells (GSCs).	23962875
Chronic Lymphocytic Leukemia, Neoplasms	Stem Cell Exhaustion	Low tumor burden is associated with early B-cell reconstitution and is a predictor of favorable outcome after non-myeloablative stem cell transplant for chronic lymphocytic leukemia.	23964650
Sleep Apnea, Obstructive, Aortic Stiffness	Stem Cell Exhaustion	Patients with obstructive sleep apnea syndrome and traditional risk factors also exhibit increased aortic and carotid stiffness, increased renal resistive index and intima-media thickness, and reduced expression of the endothelial progenitor cell marker CD34: however, these parameters were similar to those of healthy controls in patients with isolated obstructive sleep apnea syndrome.	23965549
Cessation of life, Specialty Type - cancer	Stem Cell Exhaustion	Disulfiram and doxorubicin cooperated to induce cell death as well as cellular senescence, and targeted the ESA(+)/CD24(-/low)/CD44(+) cancer stem cell population.	23974104
Osteoporotic Fractures	Stem Cell Exhaustion	In the present study, we evaluated the potential for aminobisphosphonates to enhance the development of bone-forming osteoblasts from progenitor cells isolated from aged female osteoporotic patients.	23974861
Lymphoma	Stem Cell Exhaustion	Stem cell mobilization in HIV seropositive patients with lymphoma.	23975176
AIDS-Related Hodgkin Lymphoma	Stem Cell Exhaustion	High-dose chemotherapy with autologous peripheral blood stem cell rescue has been reported as feasible and effective in HIV-associated lymphoma.	23975176
HIV Infections	Stem Cell Exhaustion	HIV infection alone should not preclude an attempt to obtain stem cells in candidates for autologous transplant as the results are comparable to the HIV-negative population.	23975176
Bacteremia, Communicable Diseases	Stem Cell Exhaustion	Oral infection may be a source of bacteremia in patients undergoing hematopoietic stem cell transplant (HSCT).	23975228
Communicable Diseases	Stem Cell Exhaustion	[Prevalence of EBV infection in patients with allogeneic hematopoietic stem cell transplantation].	23978013
Chronic graft-versus-host disease	Stem Cell Exhaustion	[Association of the ratio of regulatory and effector T cells with recurrence and chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation].	23978019
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	To investigate the association of the ratio of regulatory and effector T cells with recurrence and chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT).	23978019
Adenocarcinoma of pancreas	Stem Cell Exhaustion	Modulation of c-kit expression in pancreatic adenocarcinoma: a novel stem cell marker responsible for the progression of the disease.	23978330
Specialty Type - cancer	Stem Cell Exhaustion	The absence of c-kit in normal pancreas and its appearance in PDAC is probably due to a mutational event, which probably allows conversion of the b cells into cancer stem cells (CSC).	23978330
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Long-term results of a prospective randomized trial evaluating G-CSF priming in intensive induction chemotherapy followed by autologous stem cell transplantation in elderly patients with acute myeloid leukemia.	23978944
Acute Radiation Syndrome	Stem Cell Exhaustion	Severe acute radiation syndrome: treatment of a lethally 60Co-source irradiated accident victim in China with HLA-mismatched peripheral blood stem cell transplantation and mesenchymal stem cells.	23979075
Leukemia, Myelocytic, Acute, Acute leukemia	Stem Cell Exhaustion	Allogeneic hematopoietic stem-cell transplantation for acute myeloid leukemia in remission: comparison of intravenous busulfan plus cyclophosphamide (Cy) versus total-body irradiation plus Cy as conditioning regimen--a report from the acute leukemia working party of the European group for blood and marrow transplantation.	23980086
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Cyclophosphamide (Cy) combined with total-body irradiation (TBI) or with busulfan (Bu) are currently the most common myeloablative regimens used in allogeneic stem-cell transplantation (alloSCT) in adults with acute myelogenous leukemia (AML).	23980086
Acute myocardial infarction	Stem Cell Exhaustion	In experimental studies, mesenchymal stem cell (MSC) transplantation in acute myocardial infarction (AMI) models has been associated with enhanced neovascularization and myogenesis.	23982478
Acute myocardial infarction	Stem Cell Exhaustion	Intramyocardial injection of autologous bone marrow-derived ex vivo expanded mesenchymal stem cells in acute myocardial infarction patients is feasible and safe up to 5 years of follow-up.	23982478
Papillary thyroid carcinoma, Anaplastic thyroid carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Expression of cancer stem cell markers is more frequent in anaplastic thyroid carcinoma compared to papillary thyroid carcinoma and is related to adverse clinical outcome.	23986551
Specialty Type - cancer	Stem Cell Exhaustion	Additionally, the cancer stem cell (CSC) theory has been widely accepted in the pathogenesis of ATC.	23986551
Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	Cognitive and psychosocial function post hematopoietic stem cell transplantation in children with hemophagocytic lymphohistiocytosis.	23987797
Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	This study investigated the cognitive and psychosocial outcomes in childhood survivors of hemophagocytic lymphohistiocytosis after hematopoietic stem cell transplantation.	23987797
Glioblastoma Multiforme Pathway, Neoplasms	Stem Cell Exhaustion	Recent evidence suggests that a glioma stem cell subpopulation may determine the biological behavior of tumors, including resistance to therapy.	23991844
Glioma, Neoplasms	Stem Cell Exhaustion	To investigate this hypothesis, the authors examined varying grades of gliomas for stem cell marker expressions and histopathological changes between primary and recurrent tumors.	23991844
Glioblastoma Multiforme Pathway, Specialty Type - cancer, Glioblastoma	Stem Cell Exhaustion	The authors' results indicate that CD133-positive glioma stem cells could survive, change to a proliferative cancer stem cell phenotype, and cause recurrence in cases with de novo glioblastomas after radiotherapy and chemotherapy.	23991844
Peripheral Arterial Diseases	Stem Cell Exhaustion	Regeneration of the occluded peripheral arteries by autologous stem cell therapy is an emerging treatment modality for no-option patients with peripheral artery disease (PAD).	23993298
Multiple Myeloma	Stem Cell Exhaustion	Evolving strategies with immunomodulating drugs and tandem autologous/allogeneic hematopoietic stem cell transplantation in first line high risk multiple myeloma patients.	23994781
Toxic effect, Multiple Myeloma	Stem Cell Exhaustion	We prospectively evaluated in high-risk myeloma patients the efficacy and toxicity of tandem autologous hematopoietic stem cell transplantation (auto-HSCT) followed by reduced-intensity conditioning (RIC) and allogeneic (allo)-HSCT with bortezomib and donor lymphocyte infusions introduction after allo-HSCT (group 1).	23994781
Hantavirus Infections, Subcutaneous panniculitis-like T-cell lymphoma, Histiocytosis haematophagic	Stem Cell Exhaustion	Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) with hemophagocytosis (HPS): successful treatment using high-dose chemotherapy (BFM-NHL & ALL-90) and autologous peripheral blood stem cell transplantation.	23995110
Bacteremia	Stem Cell Exhaustion	Incidence, risk factors, and outcome of bacteremia following autologous hematopoietic stem cell transplantation in 720 adult patients.	23995612
Bacteremia, Pregnancy Complications, Infectious, Neutropenia	Stem Cell Exhaustion	Bacteremia is the most frequent infectious complication during neutropenia in patients receiving autologous hematopoietic stem cell transplantation (ASCT).	23995612
melphalan/prednisone protocol	Stem Cell Exhaustion	At first randomization, patients (N = 1,970) were assigned to bisphosphonate (clodronic acid or zoledronic acid) and induction therapies [cyclophosphamide-vincristine-doxorubicin-dexamethasone (CVAD) or cyclophosphamide-thalidomide-dexamethasone (CTD) followed by high-dose therapy plus autologous stem cell transplantation for younger/fitter patients (intensive pathway), and melphalan-prednisone (MP) or attenuated CTD (CTDa) for older/less fit patients (nonintensive pathway)].	23995858
Renal Insufficiency, Multiple Myeloma	Stem Cell Exhaustion	Bortezomib before and after autologous stem cell transplantation overcomes the negative prognostic impact of renal impairment in newly diagnosed multiple myeloma: a subgroup analysis from the HOVON-65/GMMG-HD4 trial.	23996482
Renal Insufficiency, Multiple Myeloma	Stem Cell Exhaustion	This analysis evaluates the prognostic role of renal impairment in patients with myeloma treated with bortezomib before and after autologous stem cell transplantation within a prospective randomized phase III trial.	23996482
Multiple Myeloma	Stem Cell Exhaustion	Eight hundred and twenty-seven newly diagnosed myeloma patients in the HOVON-65/GMMG-HD4 trial were randomized to receive three cycles of vincristine, adriamycin, dexamethasone (VAD) or bortezomib, adriamycin, dexamethasone (PAD) followed by autologous stem cell transplantation and maintenance with thalidomide 50 mg daily (VAD-arm) or bortezomib 1.3 mg/m(2) every 2 weeks (PAD-arm).	23996482
Renal Insufficiency, Multiple Myeloma	Stem Cell Exhaustion	We conclude that a bortezomib-containing treatment before and after autologous stem cell transplantation overcomes the negative prognostic impact of renal impairment in patients with newly diagnosed multiple myeloma.	23996482
Chronic myeloproliferative disorder	Stem Cell Exhaustion	Ploycythaemia vera (PV) is most common of chronic myeloproliferative disorder that involves the multipotent haemaotopoietic progenitor cells.	24000512
Medial collateral ligament, Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Stem Cell Exhaustion	Although dose-intensive strategies or high-dose therapy induction followed by autologous stem-cell transplantation have improved the outcome for patients with mantle-cell lymphoma (MCL), most eventually relapse and subsequently respond poorly to additional therapy.	24002500
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Identification of gene expression-based prognostic markers in the hematopoietic stem cells of patients with myelodysplastic syndromes.	24002510
Tracheal Stenosis	Stem Cell Exhaustion	Replacement of a tracheal stenosis with a tissue-engineered human trachea using autologous stem cells: a case report.	24004248
Tracheal Stenosis	Stem Cell Exhaustion	In this study, using a detergent-enzymatic method, we prepared an intact three-dimensional scaffold of an extracellular matrix derived from a human cadaver donor trachea, which we repopulated with autologous stem cells and implanted into a 76-year-old patient with tracheal stenosis including the lower part of the larynx.	24004248
Lymphoma, Vomiting, Multiple Myeloma, Nausea	Stem Cell Exhaustion	Combined use of multiday palonosetron with aprepitant and low-dose dexamethasone in prevention of nausea and emesis among patients with multiple myeloma and lymphoma undergoing autologous hematopoietic stem cell transplant: A pilot study.	24005093
Refractory Chemotherapy-Induced Nausea and Vomiting	Stem Cell Exhaustion	The current standard for prevention of chemotherapy-induced nausea/vomiting in autologous stem cell transplant only achieves 4-20% emetic control.	24005093
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	To assess emetic responses to multiday palonosetron, aprepitant, and low-dose dexamethasone among patients with myeloma and lymphoma undergoing autologous hematopoietic stem cell transplant.	24005093
Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	Because testicular germ cell tumor recurrence and other malignant tumors could be ruled out pathologically, he was diagnosed as having AML.Allogeneic stem cell transplantation from a HLA-matched sibling donor was performed after chemotherapy.	24005437
Specialty Type - cancer	Stem Cell Exhaustion	Critics have suggested that neoadjuvant chemotherapy (NACT) followed by interval debulking may select for resistant clones or cancer stem cells when compared to primary cytoreduction.	24005572
Lymphoma	Stem Cell Exhaustion	High-dose therapy with autologous stem cell support for lymphoma in Norway 1987-2008.	24005706
Lymphoma	Stem Cell Exhaustion	High-dose therapy with autologous stem cell support (HDT) has been a treatment option for lymphomas in Norway for 25 years.	24005706
Systemic Scleroderma	Stem Cell Exhaustion	[Treatment and course of a man with systemic sclerosis before and after hematopoetic blood stem cell transplantation].	24006162
Sclerosis of the skin	Stem Cell Exhaustion	Six months after blood stem cell transplantation a decrease of skin sclerosis and an increasing recovery of joint mobility and physical strength was observed.	24006162
Systemic Scleroderma	Stem Cell Exhaustion	Patients with a progressive systemic sclerosis and further risk factors should be treated with high-dose chemotherapy with blood stem cell transplantation before organ function is severely compromised.	24006162
Antilymphocyte Serum	Stem Cell Exhaustion	Stem cell transplantation is a potential therapeutic strategy for ALS, and the reprogramming of adult somatic cells into induced pluripotent stem cells (iPSCs) represents a novel cell source.	24006477
Amyotrophic Lateral Sclerosis	Stem Cell Exhaustion	Minimally invasive transplantation of iPSC-derived ALDHhiSSCloVLA4+ neural stem cells effectively improves the phenotype of an amyotrophic lateral sclerosis model.	24006477
Adenoma	Stem Cell Exhaustion	We evaluated the expression of aldehyde dehydrogenase isoform 1A1 (ALDH1A1), a putative stem cell marker, in baseline adenomas from the placebo arm of chemoprevention trial participants with colonoscopic follow-up.	24008128
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells have tumor-initiation and tumor-maintenance capabilities.	24008128
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	The present study supports the hypothesis that the stem cell population can be enriched in cells expressing the CD133 cell surface marker and that highly expressed CD133 is involved in the occurrence of NSCLC.	24008862
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSCs) are a small population of undifferentiated cancer cells within tumors, which contribute to tumorigenicity and relapse.	24008862
Colorectal Carcinoma, Neoplasms, Cytogenetic Complete Response	Stem Cell Exhaustion	CD44 marks stem cell-like cells in a number of tumour types, including colorectal cancer (CRC), while aberrant CD44 expression conveys increased tumourigenic, invasive, and metastatic potential.	24009708
Liver carcinoma	Stem Cell Exhaustion	We investigated the transcription program deregulated in hepatocellular carcinomas with stem cell features.	24012616
Liver carcinoma	Stem Cell Exhaustion	The transcription factor SALL4, known to regulate stemness in embryonic and hematopoietic stem cells, was found to be activated in a hepatocellular carcinoma subtype with stem cell features.	24012616
Specialty Type - cancer	Stem Cell Exhaustion	Activation of SALL4 enhanced spheroid formation and invasion capacities, key characteristics of cancer stem cells, and up-regulated the hepatic stem cell markers KRT19, EPCAM, and CD44 in cell lines.	24012616
Liver carcinoma	Stem Cell Exhaustion	SALL4 is a valuable biomarker and therapeutic target for the diagnosis and treatment of hepatocellular carcinoma with stem cell features.	24012616
Fibrosis Assessment	Stem Cell Exhaustion	To determine the effect of fibrosis on healthy hematopoietic progenitor cells (HPCs), bioartificial matrixes from rat tail or purified human collagen were found to suppress HPC differentiation and proliferation.	24014875
Malignant neoplasm of lung	Stem Cell Exhaustion	To investigate the expression of the stem cell marker Nanog in lung cancer tissues and the correlations between Nanog expression and clinic-pathologic characteristics as well as prognosis of lung cancer.	24018162
Leukemia, Myelocytic, Acute, Acute lymphocytic leukemia	Stem Cell Exhaustion	We analyzed 3339 patients with acute myeloid leukemia and 1434 patients with acute lymphoblastic leukemia who received myeloablative conditioning and related or unrelated stem cells from 1990 to 2005.	24018394
MS gene	Stem Cell Exhaustion	With autologous mesenchymal stem cell therapy now in the early phases of clinical trials for all forms of multiple sclerosis (MS), it is necessary to determine whether autologous stem cells from older donors have therapeutic effectiveness.	24018793
Experimental Autoimmune Encephalomyelitis	Stem Cell Exhaustion	Age of the donor reduces the ability of human adipose-derived stem cells to alleviate symptoms in the experimental autoimmune encephalomyelitis mouse model.	24018793
Sepsis	Stem Cell Exhaustion	He suffered persistent neutropaenic sepsis and clinical deterioration forced the strategy of matched sibling haematopoietic stem cell transplantation.	24019212
Toxic effect, Anthracycline Antibiotics	Stem Cell Exhaustion	First-line treatment with anthracycline-based polychemotherapy followed by consolidation with high-dose therapy and autologous stem cell transplant in responding patients has demonstrated good feasibility with low toxicity in prospective studies and is widely used in eligible patients.	24020452
Malignant tumor of colon, Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cell gene profile as predictor of relapse in high risk stage II and stage III, radically resected colon cancer patients.	24023782
Colorectal Carcinoma, Malignant tumor of colon	Stem Cell Exhaustion	This analysis supports the idea that, other than stage, biological variables, such as expression levels of colon cancer stem cell genes, may be relevant in determining an increased risk of relapse in resected colorectal cancer patients.	24023782
Colorectal Carcinoma, Specialty Type - cancer, Malignant tumor of colon	Stem Cell Exhaustion	Preclinical findings suggest that cancer stem cells may influence the biological behaviour of colorectal cancer independently from stage: objective of the study was to assess whether a panel of stemness markers were correlated with clinical outcome in resected stage II and III colon cancer patients.	24023782
Malignant neoplasm of stomach	Stem Cell Exhaustion	SNPs in the Prostate Stem Cell Antigen (PSCA) gene have been found associated with gastric cancer (GC) risk in a genome-wide association study.	24023815
Down Syndrome	Stem Cell Exhaustion	Usp16 contributes to somatic stem-cell defects in Down's syndrome.	24025767
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Forty-two CLL patient samples were repeatedly analyzed after allogeneic stem cell transplantation (n = 20) or after fludarabine-based therapy (n = 22), and 100% concordance was found using both flow cytometric protocols.	24028768
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Blood-derived circulatory angiogenic cells (CACs) and resident cardiac stem cells (CSCs) have both been shown to improve cardiac function after myocardial infarction.	24030393
melanoma	Stem Cell Exhaustion	The intermediate filament nestin, a neural stem-cell marker, is reported to be expressed more strongly in melanomas compared with benign melanocytic lesions, and increasingly expressed in advanced melanoma stages.	24030749
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	This international, multicentre phase II study was conducted to assess ofatumumab, a human anti-CD20 monoclonal antibody, in patients with relapsed/progressive diffuse large B-cell lymphoma (DLBCL) who were ineligible for autologous stem cell transplantation (TI) or who had relapse/progression after transplantation (PT).	24032456
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Decreased and dysfunctional circulating endothelial progenitor cells in patients with chronic obstructive pulmonary disease.	24033940
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	In order to define the altered pulmonary vascular homeostasis in chronic obstructive pulmonary disease, we sought to observe the level and functions of circulating endothelial progenitor cells in patients with chronic obstructive pulmonary disease.	24033940
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Adhesion, proliferation, production of nitric oxide, and expression of endothelial nitric oxide synthase and phosphorylated-endothelial nitric oxide synthase were detected to determine functions of circulating endothelial progenitor cells in patients with chronic obstructive pulmonary disease.	24033940
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	The number of circulating endothelial progenitor cells in the chronic obstructive pulmonary disease group was lower than in the control group: (0.54 +- 0.16)% vs. (1.15 +- 0.57)%, P < 0.05.	24033940
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Compared with the control, there were significantly fewer adhering endothelial progenitor cells in chronic obstructive pulmonary disease patients: 18.7 +- 4.8/field vs. 45.0 +- 5.9/field, P < 0.05.	24033940
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	The proliferation assay showed that the proliferative capacity of circulating endothelial progenitor cells from chronic obstructive pulmonary disease patients was significantly impaired: 0.135 +- 0.038 vs. 0.224 +- 0.042, P < 0.05.	24033940
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Circulating endothelial progenitor cells were decreased and functionally impaired in patients with chronic obstructive pulmonary disease.	24033940
Dyskeratosis Congenita	Stem Cell Exhaustion	Fludarabine, low-dose cyclophosphamide and rabbit antithymocyte globulin allowed stable engraftment after allogeneic peripheral blood stem cell transplantation for poly-transfused dyskeratosis congenita patient: case report.	24034063
Allogeneic Hematopoietic Stem Cell Transplantation, Crohn Disease, Acute leukemia	Stem Cell Exhaustion	Successful treatment of both acute leukemia and active Crohn's disease after allogeneic hematopoietic stem cell transplantation using reduced-intensity conditioning with fludarabine and busulfan: a case report.	24034064
Clostridium difficile colitis, Central Diabetes Insipidus	Stem Cell Exhaustion	Clostridium difficile infection (CDI) is a serious complication of chemotherapy including high-dose regimens with autologous stem cell transplantation (ASCT).	24034141
Tumor necrosis	Stem Cell Exhaustion	Interleukin-1 beta and tumor necrosis factor alpha inhibit migration activity of chondrogenic progenitor cells from non-fibrillated osteoarthritic cartilage.	24034344
cytidylyl-(3-5)-cytidine	Stem Cell Exhaustion	Migratory chondrogenic progenitor cells (CPC) might represent a target cell population for in situ regeneration.	24034344
Electrocardiogram: myocardial infarction (finding), Ventricular Dysfunction	Stem Cell Exhaustion	Intracoronary cardiosphere-derived cells after myocardial infarction: evidence of therapeutic regeneration in the final 1-year results of the CADUCEUS trial (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction).	24036024
Ventricular Dysfunction	Stem Cell Exhaustion	This study sought to report full 1-year results, detailed magnetic resonance imaging analysis, and determinants of efficacy in the prospective, randomized, controlled CADUCEUS (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction) trial.	24036024
Caduceus, Ventricular Dysfunction	Stem Cell Exhaustion	(CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction [CADUCEUS]; NCT00893360).	24036024
Thymic Lymphoma	Stem Cell Exhaustion	Somatic inactivation of Tp53 in hematopoietic stem cells or thymocytes predisposes mice to thymic lymphomas with clonal translocations.	24036547
Hematoma, Subdural	Stem Cell Exhaustion	The level of circulating endothelial progenitor cells may be associated with the occurrence and recurrence of chronic subdural hematoma.	24037002
Hematoma, Subdural, Chronic, Hematoma, Subdural	Stem Cell Exhaustion	This study was designed to observe the levels of endothelial progenitor cells, white blood cells, platelets, and other indicators in the peripheral blood of patients diagnosed with chronic subdural hematoma to determine the possible relationship between the endothelial progenitor cells and the occurrence, development, and outcomes of chronic subdural hematoma.	24037002
Hematoma	Stem Cell Exhaustion	The level of endothelial progenitor cells in peripheral blood was significantly lower in preoperational patients with chronic subdural hematomas than in controls.	24037002
Hematoma	Stem Cell Exhaustion	The level of circulating endothelial progenitor cells in chronic subdural hematoma patients was significantly lower than the level in healthy controls.	24037002
Hematoma, Subdural	Stem Cell Exhaustion	Endothelial progenitor cells may be related to the occurrence and recurrence of chronic subdural hematoma.	24037002
Graft-vs-Host Disease	Stem Cell Exhaustion	Effective prevention of GVHD using in vivo T-cell depletion with anti-lymphocyte globulin in HLA-identical or -mismatched sibling peripheral blood stem cell transplantation.	24037022
Bone necrosis	Stem Cell Exhaustion	Aberrant CpG islands' hypermethylation of ABCB1 in mesenchymal stem cells of patients with steroid-associated osteonecrosis.	24037553
Impaired T cell function	Stem Cell Exhaustion	We investigated whether aberrant dinucleotide CpG islands' hypermethylation of ABCB1 gene existed in mesenchymal stem cells (MSC) of patients with ONFH, which results in cell dysfunction.	24037553
leukemia, Acute leukemia	Stem Cell Exhaustion	CMV serostatus still has an important prognostic impact in de novo acute leukemia patients after allogeneic stem cell transplantation: a report from the Acute Leukemia Working Party of EBMT.	24037724
Acute leukemia	Stem Cell Exhaustion	We analyzed the prognostic impact of donor and recipient cytomegalovirus (CMV) serostatus in 16,628 de novo acute leukemia patients after allogeneic stem cell transplantation (allo-SCT).	24037724
Astrocytoma	Stem Cell Exhaustion	A study of embryonic stem cell-related proteins in human astrocytomas: identification of Nanog as a predictor of survival.	24037901
Glioma, Childhood Breast Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	An embryonic stem cell (ESC) gene signature was found to correlate with a more undifferentiated phenotype of several human cancer types including gliomas, and associated with poor prognosis in breast cancer.	24037901
Malignant Neoplasms	Stem Cell Exhaustion	Recent studies suggest that the regulatory networks controlling the functions of stem cells during development may be abnormally active in human cancers.	24037901
Cytomegalovirus DNA, Aspergillosis	Stem Cell Exhaustion	An investigation on the relationship between the occurrence of CMV DNAemia and the development of invasive aspergillosis in the allogeneic stem cell transplantation setting.	24037906
Communicable Diseases, Mycoses	Stem Cell Exhaustion	Cytomegalovirus (CMV) infection might increase the risk of fungal superinfection in allogeneic stem cell transplant patients.	24037906
Injury wounds	Stem Cell Exhaustion	We evaluated the treatment of excisional and diabetic wounds using a stem cell isolated from the human umbilical cord Wharton's jelly (hWJSC) that shares unique properties with embryonic and adult mesenchymal stem cells.	24038311
Injury wounds	Stem Cell Exhaustion	Human Wharton's jelly stem cells and its conditioned medium enhance healing of excisional and diabetic wounds.	24038311
Neoplasms	Stem Cell Exhaustion	Irradiation of juvenile, but not adult, mammary gland increases stem cell self-renewal and estrogen receptor negative tumors.	24038768
Neoplasms	Stem Cell Exhaustion	Here we show that pubertal murine mammary glands exposed to sparsely or densely ionizing radiation exhibit enrichment of mammary stem cell and Notch pathways, increased mammary repopulating activity indicative of more stem cells, and propensity to develop estrogen receptor (ER) negative tumors thought to arise from stem cells.	24038768
Childhood Breast Carcinoma	Stem Cell Exhaustion	These studies suggest that irradiation during puberty transiently increases stem cell self-renewal, which increases susceptibility to developing ER-negative breast cancer.	24038768
Fracture, Hematoma	Stem Cell Exhaustion	Previously, we reported that progenitor cells with osteogenic and chondrogenic potential exist in human fracture haematoma, suggesting that the fracture haematoma-derived progenitor cells (HCs) contribute to fracture healing.	24039091
Malignant tumor of colon, Specialty Type - cancer	Stem Cell Exhaustion	Cancer-initiating cells [cancer stem cells (CSCs)] in colon cancer cells can be selectively suppressed when they are cultured on Pluronic (nanosegment)-grafted dishes, whereas CSCs are maintained on conventional tissue culture dishes and extracellular matrix-coated dishes.	24039170
Malignant tumor of colon	Stem Cell Exhaustion	CSCs can be selectively suppressed from colon cancer cells containing adipose-derived stem cells (ADSCs) on Pluronic-grafted dishes, while ADSCs remain on the dishes.	24039170
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Despite improvements in human leukocyte antigen matching and pharmacologic prophylaxis, acute graft-versus-host disease (GVHD) is often a fatal complication following hematopoietic stem cell transplant (HSCT).	24040397
Specialty Type - cancer	Stem Cell Exhaustion	To evaluate the safety, tolerability, pharmacokinetics and antitumor activities of famitinib (famitinib L-malate), a novel oral multitargeting tyrosine kinase inhibitor that acts against vascular endothelial growth factor receptor-2, platelet-derived growth factor receptor, stem cell factor receptor (c-kit), FMS-like tyrosine kinase-3 receptor and protooncogene tyrosine kinase receptor in patients with advanced solid cancer.	24043137
Lymphoma, Follicular	Stem Cell Exhaustion	Clinical outcomes of allogeneic stem cell transplantation for relapsed or refractory follicular lymphoma: a retrospective analysis by the Fukuoka Blood and Marrow Transplantation Group.	24043582
Lymphoma, Follicular	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (allo-SCT) is considered the only curative treatment for relapsed or refractory follicular lymphoma (FL), but it has a high treatment-related mortality rate.	24043582
CLU protein, human, Ischemia	Stem Cell Exhaustion	Stem cells have been successfully used for the treatment of critical limb ischemia (CLI).	24043757
Multiple Myeloma	Stem Cell Exhaustion	We prospectively evaluated the effect of bortezomib, thalidomide and dexamethasone (VTD) consolidation on bone metabolism of 42 myeloma patients who underwent an autologous stem cell transplantation (ASCT).	24045498
Neoplasms	Stem Cell Exhaustion	In particular, SKOV3 cells with miR-106a overexpression had significantly higher tumor initial/stem cell population (CD24- and CD133-positive cells) than control SKOV3 cells.	24045973
Myoma, physiopathological	Stem Cell Exhaustion	The possible pathogenetic mechanisms include hormonal dysfunction, differentiation of subperitoneal mesenchymal stem cells, myofibroblastic metaplasia and genetic and iatrogenic causes (resection of myomas during laparoscopic surgery).	24047039
Heart failure	Stem Cell Exhaustion	Decreased circulating endothelial progenitor cell levels in patients with heart failure with preserved ejection fraction.	24051936
Heart failure	Stem Cell Exhaustion	The purpose of this study was to explore the relationship between endothelial progenitor cell (EPC) levels, heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF).	24051936
Lupus Erythematosus	Stem Cell Exhaustion	Endothelial progenitor cells in systemic lupus erythematosus.	24052468
Stem cells	Stem Cell Exhaustion	This is characterized by increased cytokine secretion, loss of stem cell markers, and astrocytic differentiation.	24052948
Adult Glioblastoma, Specialty Type - cancer	Stem Cell Exhaustion	Furthermore, glioblastoma assays reveal that irradiation therapy affects the tumorigenic potential of cancer stem cells by ablating self-renewal and inducing astroglial differentiation.	24052948
Tumor necrosis, Pneumoconiosis	Stem Cell Exhaustion	In the patients with pneumoconiosis, the highly expressed serum cytokines included interleukin (IL)-1a, IL-1b, IL-2, ILs 4-16, macrophage colony-stimulating factor, interferon-g, tumor necrosis factor (TNF)-a, TNF-b, human bone morphogenetic protein-6, fibroblast growth factor-7, neurotrophin-3, and stem cell factor, and the lowly expressed serum cytokines included recombinant human I-309, monocyte chemoattractant protein (MCP)-1, MCP-2, MCP-3, MCP-4, macrophage inflammatory protein (MIP)-1-d, and MIP-3-a.	24053915
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Prevalence of extramedullary relapses is higher after allogeneic stem cell transplantation than after chemotherapy in adult patients with acute myeloid leukemia.	24054717
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Although studies have demonstrated a high prevalence of extramedullary (EM) relapse after allogeneic stem cell transplantation (allo-SCT) in patients with acute myeloid leukemia (AML), the prevalence of EM relapse has not been compared with that after chemotherapy.	24054717
Hemangioma, Hemangiosarcoma	Stem Cell Exhaustion	In the present study, we semiquantitatively evaluated the expression profiles of hematopoietic stem cell markers (CD117 [c-kit], CD133, CD34, and CD45), endothelial cell markers (vascular endothelial growth factor receptor 2, CD31, and factor VIII-related antigen), and a myeloid lineage cell marker (CD14) in human hemangiosarcoma (n = 12) and hemangioma (n = 10) specimens using immunohistochemistry.	24054722
Hemangioma, Hemangiosarcoma	Stem Cell Exhaustion	Our results indicate that multipotential bone marrow-derived hematopoietic stem cells or early endothelial progenitor cells (EPCs) expressing CD117, CD34, and CD45 are involved in hemangiosarcoma formation, whereas hemangiomas originate from late EPCs or differentiated endothelial cells, which have lost the expression of most hematopoietic stem cell markers.	24054722
Heart failure	Stem Cell Exhaustion	Changes in circulating progenitor cells are associated with outcome in heart failure patients: a longitudinal study.	24054922
Cardiovascular Diseases	Stem Cell Exhaustion	Circulating progenitor cells (CPCs) are involved in the process of endothelial repair and are a prognostic factor in cardiovascular diseases.	24054922
Diabetes	Stem Cell Exhaustion	Depletion of circulating progenitor cells precedes overt diabetes: a substudy from the VA enhanced fitness trial.	24055327
Diabetes, "cytidylyl-(3-5)-cytidine	Stem Cell Exhaustion	While depletion of circulating progenitor cells (CPCs) has been noted in diabetes, the degree to which CPC depletion predates and is associated with propensity to develop overt disease is unclear.	24055327
Lymphoma, Follicular	Stem Cell Exhaustion	Collection of hematopoietic stem cells after previous radioimmunotherapy is feasible and does not impair engraftment after autologous stem cell transplantation in follicular lymphoma.	24055654
Lymphoma, Follicular, Toxic effect	Stem Cell Exhaustion	Major concerns about radioimmunotherapy (RIT) administration early in the course of follicular lymphoma (FL) are long-term toxicity and the theoretical impairment of hematopoietic stem cell (HSC) harvest, but few data are available about mobilization rates after RIT.	24055654
Thrombotic Microangiopathies	Stem Cell Exhaustion	Serum neutrophil extracellular trap levels predict thrombotic microangiopathy after allogeneic stem cell transplantation.	24055655
Thrombotic Microangiopathies	Stem Cell Exhaustion	Transplantation-associated thrombotic microangiopathy (TA-TMA) is a devastating complication of hematopoietic stem cell transplantation.	24055655
Neurotoxicity Syndromes, "Alzheimers Disease	Stem Cell Exhaustion	Efficient derivation of cortical glutamatergic neurons from human pluripotent stem cells: a model system to study neurotoxicity in Alzheimer's disease.	24055772
Neurotoxicity Syndromes, Up	Stem Cell Exhaustion	In particular, disease-relevant models based on human pluripotent stem cells (hPSCs) may be promising approaches to assess the impact of neurotoxic agents in AD on specific neuronal populations and thereby facilitate the development of novel interventions to avert early disease mechanisms.	24055772
Malignant Neoplasms	Stem Cell Exhaustion	Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation.	24055823
Malignant Neoplasms	Stem Cell Exhaustion	New treatments are needed for B-cell malignancies persisting after allogeneic hematopoietic stem cell transplantation (alloHSCT).	24055823
CORIN gene	Stem Cell Exhaustion	Corin is also expressed in chondrocytes and bone marrow-derived mesenchymal stem cells that undergo osteogenic differentiation, suggesting a potential role of corin in bone formation and homeostasis.	24056022
BCR gene	Stem Cell Exhaustion	Reduced-intensity allogeneic stem cell transplantation for patients aged 50 years or older with B-cell ALL in remission: a retrospective study by the Adult ALL Working Group of the Japan Society for Hematopoietic Cell Transplantation.	24056740
Specialty Type - cancer	Stem Cell Exhaustion	Coexpression of both oncoproteins in cultured cells led to the activation of a c-Myc transcriptional signature and acquisition of a self-renewing phenotype independent of an epithelial-mesenchymal transition programme or regulation of conventional cancer stem cell markers.	24056965
Neoplasms	Stem Cell Exhaustion	The stem cell self-renewal gene, Musashi 1, is highly expressed in tumor and non-tumor samples of human bladder.	24061461
Specialty Type - cancer	Stem Cell Exhaustion	The stem cell model for cancer assumes that a key event in tumorigenesis is the deregulation of genes involved in the regulation of stem cell self-renewal.	24061461
Malignant neoplasm of urinary bladder, Neoplasms	Stem Cell Exhaustion	To investigate a potential expression of the stem cell self-renewal gene, Musashi 1, in human bladder cancer, we examined its gene expression in a series of tumor and non-tumor tissue samples of bladder.	24061461
Coronary Arteriosclerosis	Stem Cell Exhaustion	[Effect of tongguan capsule on the number of endothelial progenitor cells in the peripheral blood of patients with coronary artery disease after PCI].	24063204
Coronary Arteriosclerosis	Stem Cell Exhaustion	To observe the effect of Tongguan Capsule (TC) on the number of endothelial progenitor cells (EPCs) in the peripheral blood of patients with coronary artery disease (CAD) after percutaneous coronary intervention (PCI).	24063204
Malignant tumor of colon	Stem Cell Exhaustion	Leucine-rich repeat-containing G protein-coupled receptor 5(LGR5) was identified as the stem cell marker of colon cancer stem cells(CSCs),which were considered as the main criminal cells initiation and reinitiation of colon cancer.	24063790
Malignant Neoplasms	Stem Cell Exhaustion	Myc is a transcription factor having a central function in stem cell biology and in human cancers.	24063893
Acute lymphocytic leukemia	Stem Cell Exhaustion	Enlargement of bilateral kidneys by infiltration of leukemic cells in acute lymphoblastic leukemia at relapse after allogeneic hematopoietic stem cell transplantation.	24065514
Hematologic Neoplasms, Bone marrow hypocellularity	Stem Cell Exhaustion	We analysed the results of allogeneic haematopoietic stem cell transplantation (HSCT) in various genetic disorders, bone marrow failures and haematological malignancies done from 2002 to 2010 at the Army Hospital, Research and Referral, Delhi.	24066986
Fatigue	Stem Cell Exhaustion	Research suggests that patients experience increased fatigue, reduced physical activity, and diminished quality of life (QOL) after hematopoietic stem cell transplantation (HSCT).	24067357
Zygomycosis, Carotid artery occlusion	Stem Cell Exhaustion	Fatal outcome of rhino-orbital-cerebral mucormycosis due to bilateral internal carotid occlusion in a child after hematopoietic stem cell transplantation.	24067555
Cerebral Infarction, Zygomycosis, Pre B-cell acute lymphoblastic leukemia	Stem Cell Exhaustion	We present a case of fatal invasive rhino-orbito-cerebral mucormycosis complicated by bilateral thrombotic occlusion of the internal carotid artery with consequent cerebral infarction in a 5-year-old boy after hematopoietic stem cell transplantation for acute pre-B-cell lymphoblastic leukemia.	24067555
Neuroendocrine Tumors, Neoplasms	Stem Cell Exhaustion	Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms derived from endocrine stem cells.These tumors are characterized by overexpression of somatostatin receptors (SSTR), which is utilized for imaging using SSTR analogs.	24068636
Up	Stem Cell Exhaustion	In conclusion, Endoret was able to activate neuronal progenitor cells, enhancing hippocampal neurogenesis, and to reduce Ab-induced neurodegeneration in a mouse model of AD.	24069173
Ischemia	Stem Cell Exhaustion	Characterization of mesenchymal stem cells of "no-options" patients with critical limb ischemia treated by autologous bone marrow mononuclear cells.	24069226
CLU protein, human	Stem Cell Exhaustion	Mesenchymal stem cells of 41 patients with CLI unsuitable for revascularisation were isolated from mononuclear bone marrow concentrate used for their treatment.	24069226
diabetic	Stem Cell Exhaustion	The expression of mesenchymal stem cells surface markers that was analyzed in 22 patients did not differ between diabetic (n=13) and non-diabetic (n=9) patient groups.	24069226
Specialty Type - cancer, Pancreatic carcinoma	Stem Cell Exhaustion	Human pancreatic cancer contains a side population expressing cancer stem cell-associated and prognostic genes.	24069258
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	In many types of cancers, a side population (SP) has been identified based on high efflux capacity, thereby enriching for chemoresistant cells as well as for candidate cancer stem cells (CSC).	24069258
Specialty Type - cancer	Stem Cell Exhaustion	Recent data suggest that circulating endothelial and progenitor cells (CECs and CEPs, respectively) may have predictive potential in cancer patients treated with bevacizumab, the antibody recognizing vascular endothelial growth factor (VEGF).	24069296
Antilymphocyte Serum	Stem Cell Exhaustion	We evaluated the therapeutic effects of human adipose tissue-derived stem cells (ASCs) in an animal model of ALS.	24070071
Impaired T cell function	Stem Cell Exhaustion	Clinical cardiac cell therapy using autologous somatic stem cells is restricted by age and disease-associated impairment of stem cell function.	24074138
Heart failure	Stem Cell Exhaustion	Impact of heart failure on the behavior of human neonatal stem cells in vitro.	24074138
Heart failure	Stem Cell Exhaustion	We therefore evaluated the behavior of neonatal cord blood mesenchymal stem cells (CB-MSC) in the presence of serum from patients with advanced heart failure (HF).	24074138
HIV-Associated Lymphoproliferative Disorder	Stem Cell Exhaustion	Heterogeneity in clinical course of EBV-associated lymphoproliferative disorder after allogeneic stem cell transplantation.	24074746
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Post-transplant lymphoproliferative disorder (PTLD) is a severe complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT) associated with Epstein-Barr virus (EBV).	24074746
Breast Carcinoma, Childhood Breast Carcinoma	Stem Cell Exhaustion	To investigate the expression pattern of Y-box-binding protein 1 (YB1) in breast carcinomas, its clinicopathological and prognostic value, and its association with the breast cancer stem cell phenotype [CD44(+)/CD24(-/low)].	24075827
Neoplasms	Stem Cell Exhaustion	Cytoplasmic YB1 is associated with an aggressive and "stem cell-like" tumor phenotype, while nuclear localization discriminates patients at high risk for recurrence, especially those who are subjected to chemo- and radiotherapy.	24075827
Ductal Carcinoma, Childhood Breast Carcinoma	Stem Cell Exhaustion	Cytoplasmic YB1 was detected more often in carcinomas of ductal type (p = 0.002), of higher nuclear grade (p < 0.001), with lack of ER expression (p = 0.002), positive expression of p53 and Ki67 (p = 0.002 and p = 022, respectively), and with present CD44(+)/CD24(-/low) breast cancer stem cells (p = 0.001), while its association with bcl-2 was found to be inverse (p = 0.042).	24075827
Ischemic stroke	Stem Cell Exhaustion	The association between circulating endothelial progenitor cells and outcome in different subtypes of acute ischemic stroke.	24076252
Ischemic stroke	Stem Cell Exhaustion	This study evaluated the relationship between serial changes in circulating endothelial progenitor cells (EPCs) and outcomes in patients with different subtypes of acute ischemic stroke (AIS).	24076252
Retinal damage	Stem Cell Exhaustion	The potential neuroprotective effect of human adipose stem cells conditioned medium against light-induced retinal damage.	24076412
Neoplasms, Malignant neoplasm of gallbladder	Stem Cell Exhaustion	miR-34 is associated with poor prognosis of patients with gallbladder cancer through regulating telomere length in tumor stem cells.	24078448
Peripheral Blood Stem Cells	Stem Cell Exhaustion	The patient received preoperative induction chemotherapy and high-dose chemotherapy with peripheral blood stem cell support, followed by adjuvant chemotherapy and endocrine therapy.	24081811
Intrahepatic Route of Drug Administration, Hypoxia	Stem Cell Exhaustion	Chronic intermittent hypoxia (IH) acts as a stimulator of mesenchymal stem cell (MSC) mobilization, intensifying osteoblast formation in animal models.	24082310
Cachexia, Pancreatic carcinoma, Muscle damage	Stem Cell Exhaustion	In tumor-bearing mice and patients with pancreatic cancer, we found that cachexia was associated with a type of muscle damage resulting in activation of both satellite and nonsatellite muscle progenitor cells.	24084740
Multiple Myeloma	Stem Cell Exhaustion	Impact of failed response to novel agent induction in autologous stem cell transplantation for multiple myeloma.	24085241
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The aim of this study was to evaluate the impact of the response to induction therapy on the long-term prognosis of multiple myeloma (MM) after autologous stem cell transplantation (ASCT) in the era of novel agents (NAs).	24085241
Malignant Neoplasms, Lymphocyte Function, Neutropenia, Lymphopenia, Allogeneic Hematopoietic Stem Cell Transplant Recipient	Stem Cell Exhaustion	Of the 17 candidate variables analyzed, 11 correlated with IMD by univariate analysis, but only 4 risk factors (neutropenia, lymphocytopenia or lymphocyte dysfunction in allogeneic hematopoietic stem cell transplant recipients, malignancy status, and prior IMD) were retained in the final multivariate model, resulting in a weighted risk score 0-13.	24086555
Multiple Myeloma	Stem Cell Exhaustion	Total marrow irradiation as part of autologous stem cell transplantation for Asian patients with multiple myeloma.	24089671
Multiple Myeloma	Stem Cell Exhaustion	Between 2007 and 2010, nine consecutive myeloma patients who were scheduled to undergo autologous stem cell transplantation (ASCT) were studied.	24089671
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	For Hodgkin lymphoma (HL) patients with refractory or relapsed (R/R) disease after primary therapy, the standard of care is a salvage regimen followed by autologous stem cell transplant (ASCT).	24094894
Hyperplasia	Stem Cell Exhaustion	The cellular composition of the resulting hyperplastic lesions is controversial, although a population of CD133(+)CD24(+) progenitor cells has been proposed to be a major constituent.	24095923
Lymphoproliferative Disorders	Stem Cell Exhaustion	In a series of 36 renal biopsies of patients with proliferative and nonproliferative glomerulopathies, dysregulated CD133(+)CD24(+) progenitor cells of the Bowman's capsule invade the glomerular tuft exclusively in proliferative disorders.	24095923
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Outcomes of autologous or allogeneic stem cell transplantation for non-Hodgkin lymphoma.	24096123
Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Transplant outcomes of autologous or allogeneic stem cell transplantation (SCT) have not been elucidated as a single cohort in non-Hodgkin lymphoma (NHL).	24096123
Specialty Type - cancer	Stem Cell Exhaustion	Helicobacter pylori generates cells with cancer stem cell properties via epithelial-mesenchymal transition-like changes.	24096479
Specialty Type - cancer	Stem Cell Exhaustion	EMT participates in the carcinogenesis process, and is involved in the generation of cancer stem cells (CSCs).	24096479
Hematologic Neoplasms	Stem Cell Exhaustion	Single center experience with total body irradiation and melphalan (TBI-MEL) myeloablative conditioning regimen for allogeneic stem cell transplantation (SCT) in patients with refractory hematologic malignancies.	24097082
Lymphoma, Non-Hodgkin, Familial, Hematologic Neoplasms, Leukemia, Myelocytic, Acute, BCR gene	Stem Cell Exhaustion	We retrospectively evaluated the tolerability and efficacy of fractionated total body irradiation (TBI) (1,200 cGy) and melphalan (MEL) (100-110 mg/m(2)) myeloablative conditioning in 48 patients with nonremission AML (n = 14), ALL (n = 10), NHL (n = 18), and other refractory hematologic malignancies (n = 6) who received allogeneic stem cell transplantation (SCT) between 2002 and 2011.	24097082
leukemia	Stem Cell Exhaustion	Median age was 48 years (22 to 68); 14 out of 26 leukemia patients (54 %) had circulating blasts at transplant, 20 (50 %) evaluable patients had poor-risk cytogenetics, 12 (25 %) had prior SCT, and 10 (21 %) received stem cells from a mismatch donor.	24097082
Ischemic cardiomyopathy	Stem Cell Exhaustion	Transplantation of ex vivo proliferated cardiac stem cells (CSCs) is an emerging therapy for ischemic cardiomyopathy but outcomes are limited by modest engraftment and poor long-term survival.	24099706
Signal Transduction, Osteoporotic Fractures	Stem Cell Exhaustion	Mesenchymal stem cells from osteoporotic patients feature impaired signal transduction but sustained osteoinduction in response to BMP-2 stimulation.	24099772
Fracture	Stem Cell Exhaustion	Cellular sources of fracture healing are mesenchymal stem cells (MSC) that differentiate into osteoblasts by stimulation with osteoinductive cytokines, such as BMP-2.	24099772
Specialty Type - cancer, Carcinoma	Stem Cell Exhaustion	The purpose of our study was to learn the distribution characteristics of cancer stem cell markers (CD24, CD44) in invasive carcinomas with different grade and molecular subtype.	24099815
Specialty Type - cancer	Stem Cell Exhaustion	For identify cancer stem cells mononuclear antibodies CD24 (BIOCARE MEDICAL, CD44 - Clone 156-3C11; CD24 - Clone SN3b) were used.	24099815
Malignant Neoplasms	Stem Cell Exhaustion	As well as amount of CD24 positive cases according to malignancy degree, also antigen expression features does not show any type of correlation between malignancy degree and CD24 positivity or with CD24 expression features, or presence of stem cells.	24099815
Adenomatous Polyps	Stem Cell Exhaustion	However, a common stem/progenitor cell origin of both the adenomatous and neuronal component of these lesions has been suggested.	24101276
Specialty Type - cancer	Stem Cell Exhaustion	Expression of human CD133 (human prominin-1) in cancer cells has been postulated to be a marker of stemness and is considered as a putative marker of cancer stem cells (CSCs).	24102054
Congestive heart failure	Stem Cell Exhaustion	Expression of platelet-bound stromal-cell derived factor-1 (SDF-1) and number of CD34(+) progenitor cells in patients with congestive heart failure.	24102302
Congestive heart failure	Stem Cell Exhaustion	The aim of our study was to evaluate expression of platelet-bound SDF-1 and number of CD34(+) progenitor cells in patients with CHF.	24102302
Ventricular Dysfunction, Left	Stem Cell Exhaustion	Similar to platelet-bound SDF-1 number of CD34(+) progenitor cells was the highest in severe impairment of left ventricular systolic function (mild vs. moderate vs. severe impairment of left ventricular systolic function: mean +- SD: 260.4 +- 177.5 vs. 580.7 +- 340.5 vs. 640.82 +- 370.6, Kruskal-Wallis p < 0.001).	24102302
Congestive heart failure	Stem Cell Exhaustion	Platelet-bound SDF-1 expression was associated with number of circulating CD34(+) progenitor cells (r = 0.454, p < 0.001) in patients with CHF.	24102302
Congestive heart failure, Ventricular Dysfunction, Left	Stem Cell Exhaustion	Platelet-bound SDF-1 and CD34(+) progenitor cells are especially increased in patients with severe impairment of left ventricular systolic function in CHF.	24102302
Intraocular Infection	Stem Cell Exhaustion	Absence of intraocular infections after hematopoietic stem cell transplantation at a single center: the experience with current preventive regimens.	24102631
Intraocular Infection	Stem Cell Exhaustion	To investigate the prevalence of intraocular infections after allogeneic stem cell transplantation (allo-SCT).	24102631
Neoplasms	Stem Cell Exhaustion	Identification of brain tumour initiating cells using the stem cell marker aldehyde dehydrogenase.	24103144
Neoplasms	Stem Cell Exhaustion	This study aimed to evaluate the potential of ALDH as a universal brain tumour initiating cell (BTIC) marker applicable to primary brain tumours and their biological role in maintaining stem cell status.	24103144
Malignant neoplasm of ovary	Stem Cell Exhaustion	CD24 and Nanog identify stem cells signature of ovarian epithelium and cysts that may develop to ovarian cancer.	24103524
Impaired cognition, Multiple Myeloma	Stem Cell Exhaustion	Acute cognitive impairment in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplant.	24105672
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Few studies have examined the acute effects of autologous hematopoietic stem cell transplantation (Au-HSCT) on the neuropsychological functioning of patients with multiple myeloma (MM).	24105672
Ischemia	Stem Cell Exhaustion	HIF-prolyl hydroxylase 2 inhibition enhances the efficiency of mesenchymal stem cell-based therapies for the treatment of critical limb ischemia.	24105925
PAFAH1B1 wt Allele, Hematological Disease, Dysplasia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is a heterogeneous clonal disorder of hematopoietic stem cells that occurs in elderly subjects and is characterized by dysplasia and ineffective hematopoiesis.	24106013
Graft-vs-Host Disease	Stem Cell Exhaustion	Conditioning regimen including fludarabine, intravenous busulfan (Bx), and 5 mg/kg total dose of rabbit antithymocyte globulin (r-ATG) (FBx-ATG) results in low incidence of graft-versus-host disease (GVHD) and non-relapse mortality (NRM) after allogeneic hematopoietic stem cell transplantation (Allo-HSCT) from HLA-matched related or unrelated donors (MUD).	24108528
Haiti	Stem Cell Exhaustion	Treatments for HT included autologous stem-cell transplant (auto-SCT) (n = 50), allogeneic SCT (allo-SCT) (n = 18), and treatment without transplant (n = 50).	24111533
Tebi, Renal carnitine transport defect	Stem Cell Exhaustion	Quantification of HBG mRNA in erythroid progenitor cell cultures from patients with SCD and TI is predictive of their clinical response to HU.	24112139
Graft-vs-Host Disease, Allogeneic Hematopoietic Stem Cell Transplantation	Stem Cell Exhaustion	To further define the relative impact of immunotherapy and subsequent development of graft-versus-host disease (GVHD) on survival in patients with relapsed acute leukaemia postallogeneic hematopoietic stem cell transplant (SCT), we performed a single-centre retrospective analysis of 32 actively treated patients between 2003 and 2011.	24112249
Chronic graft-versus-host disease, Acute leukemia	Stem Cell Exhaustion	Immunotherapy following relapse of acute leukaemia after T-cell-replete allogeneic peripheral blood progenitor cell transplantation: importance of new onset chronic graft-versus-host disease.	24112249
Malignant neoplasm of liver	Stem Cell Exhaustion	PVTT might have the characteristics of presumed liver cancer stem cells.	24114829
Osteoporosis	Stem Cell Exhaustion	Bone formation in adipose-derived stem cells isolated from elderly patients with osteoporosis: a preliminary study.	24115596
Osteoporotic Fractures	Stem Cell Exhaustion	We have explored the osteogenic potency of adipose-derived stem cells from osteoporotic patients (opASCs).	24115596
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Comparison of allogeneic stem cell transplantation and non-transplant approaches in elderly patients with advanced myelodysplastic syndrome: optimal statistical approaches and a critical appraisal of clinical results using non-randomized data.	24116002
Disease, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Allogeneic stem cell transplantation (ASCT) from related or unrelated donors may cure patients with myelodysplastic syndromes (MDS), a heterogeneous group of clonal stem cell disorders.	24116002
Pulmonary Complication, Antilymphocyte Serum, PPCS gene	Stem Cell Exhaustion	We report on the use of non-invasive ventilation (NIV) to prevent post-operative pulmonary complications (PPCs) in nine patients affected by ALS enrolled in a phase-1 clinical trial with stem cell transplantation.	24117131
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Engraftment and outcome after autologous stem cell transplantation in plerixafor-mobilized non-Hodgkin's lymphoma patients.	24118008
Hematologic Neoplasms	Stem Cell Exhaustion	While most commonly seen in the HIV/AIDS population, patients with hematologic malignancies are also at risk following treatment protocols including monoclonal antibodies such as rituximab and after hematopoietic stem cell transplantation.	24118404
Necrosis, Bone necrosis	Stem Cell Exhaustion	To determine the efficacy of core decompression (CD) technique combined with recombinant morphogenetic proteins, autologous mesenchymal stem cells (MSCs) and xenograft bone substitute into the necrotic lesion of the femoral head on clinical symptoms and on the progression of osteonecrosis of the femoral head.	24119830
Hemorrhage, Decreased platelet count	Stem Cell Exhaustion	Stem cell transplantation can be associated with significant periods of thrombocytopenia, necessitating platelet transfusions and contributing to the risk of bleeding.	24120380
Diabetes Mellitus, Insulin-Dependent	Stem Cell Exhaustion	We have investigated the safety and efficacy of autologous bone marrow stem cell transplantation through liver puncture in two patients with recently diagnosed type 1 diabetes mellitus.	24121994
Diabetes Mellitus, Insulin-Dependent	Stem Cell Exhaustion	Early immunotherapy using autologous adult stem cells reversed the effect of anti-pancreatic islets in recently diagnosed type 1 diabetes mellitus: preliminary results.	24121994
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Improved relapse-free survival after autologous stem cell transplantation does not translate into better quality of life in chronic lymphocytic leukemia: lessons from the randomized European Society for Blood and Marrow Transplantation-Intergroup study.	24123244
pidilizumab	Stem Cell Exhaustion	Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: results of an international phase II trial.	24127452
Lupus Erythematosus, Encephalitis, St. Louis	Stem Cell Exhaustion	Recent studies have shown that allogeneic bone marrow (BM)-mesenchymal stem cell transplantation (MSCT) appears to be effective in systemic lupus erythematosus (SLE) patients and lupus-prone mice, contrary to studies in syngeneic BM-MSCT.	24130040
Lupus Erythematosus	Stem Cell Exhaustion	Wnt/b-catenin signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients through the p53/p21 pathway.	24130040
Eruptions, Acute GVH disease, Infestation by Demodex	Stem Cell Exhaustion	This case of Demodex folliculitis mimicking acute GVHD highlights the need for skin biopsy in patients who have undergone a stem cell transplant with eruptions on the head and neck.	24132559
Eruptions, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 46-year-old white woman with a history of Fms-like tyrosine kinase 3 acute myeloid leukemia presented to the dermatology clinic with a 5-day history of a nonpruritic eruption on her face and neck 28 days after undergoing a double umbilical cord blood hematopoietic stem cell transplant (HSCT).	24132559
Specialty Type - cancer	Stem Cell Exhaustion	HAb18G/CD147 was associated and colocalized with cancer stem cell marker CD44s in lipid rafts.	24132924
Histogenic Process, Carcinosarcoma	Stem Cell Exhaustion	The histogenesis of carcinosarcoma of the bone remains a matter of controversy, although a multpotential stem cell theory has been proposed.	24133601
Focal glomerulosclerosis	Stem Cell Exhaustion	Allogeneic mesenchymal stem cell infusion for the stabilization of focal segmental glomerulosclerosis.	24135082
Focal Segmental Glomerulosclerosis, Not Otherwise Specified	Stem Cell Exhaustion	We describe a cell therapy treatment with human allogeneic bone marrow mesenchymal stem cells (MSC) in a 13-year-old patient developing recurrent FSGS after renal transplantation, which was not responding to conventional therapy.	24135082
Communicable Diseases, Scedosporium, Acute lymphocytic leukemia	Stem Cell Exhaustion	Here, we report the case of a 21-year-old caucasian female who developed a disseminated infection of Scedosporium prolificans after allogenic stem cell transplantation performed for treatment of relapsed acute lymphoblastic leukaemia.	24135648
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	[Successful therapy for enteropathy-associated peripheral T-cell lymphoma using high-dose polychemotherapy and autologous hematopoietic stem cell transplantation].	24137952
Monomorphic epitheliotropic intestinal T-cell lymphoma	Stem Cell Exhaustion	The article presents a literature review and a case of successful therapy in a 58-year-old patient with type I EATL using the mNHL-BFM-90 protocol and autologous hematopoietic stem cell transplantation.	24137952
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	To evaluate the efficiency of extracorporeal photopheresis (ECP) in the treatment of patients with refractory chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT).	24137966
T-Cell Lymphoma	Stem Cell Exhaustion	High-dose therapy and autologous hematopoietic stem cell transplant in T-cell lymphoma: a single center experience.	24138331
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	We report here the long-term outcome of autologous stem cell transplant in peripheral T-cell lymphoma (PTCL).	24138331
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Forty-three consecutive patients with PTCL diagnosed between 2000 and 2011 were treated with high-dose chemotherapy (HDCT) and autologous stem cell transplant (ASCT) in our center.	24138331
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	We present an interim analysis of the first prospective study in which Plerixafor was administered on-demand in patients affected by multiple myeloma and lymphoma who received high dose cyclophosphamide or DHAP (dexamethasone, cytarabine, cisplatin) plus G-CSF to mobilize peripheral blood stem cells (PBSC).	24138497
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Cytogenetic risk grouping by the monosomal karyotype classification is superior in predicting the outcome of acute myeloid leukemia undergoing allogeneic stem cell transplantation in complete remission.	24138573
Leukemia, Myelocytic, Acute, Chromosome Aberrations	Stem Cell Exhaustion	We retrospectively analyzed the impact of cytogenetic abnormalities grouped according to the monosomal karyotype (MK) classification or the Southwest Oncology/Eastern Cooperative Oncology Group (SWOG/ECOG) definition in 263 patients with acute myeloid leukemia (AML) who underwent allogeneic stem cell transplantation (alloSCT) in complete remission (CR) at our center.	24138573
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Whole-genome sequencing of clonally expanded hematopoietic stem/progenitor cells (HSPCs) from healthy individuals and a premalignant myelodysplastic syndrome (MDS) sample revealed no X chromosome hypermutation.	24139898
Lymphoma, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	High-dose etoposide plus granulocyte colony-stimulating factor as an effective chemomobilization regimen for autologous stem cell transplantation in patients with non-Hodgkin Lymphoma previously treated with CHOP-based chemotherapy: a study from the Consortium for Improving Survival of Lymphoma.	24141009
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Endothelial progenitor cells in patients with chronic obstructive pulmonary disease.	24142520
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	The objective of this study was to compare circulating endothelial progenitor cells in patients with chronic obstructive pulmonary disease to age, sex, and cigarette smoking matched healthy controls.	24142520
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	In contrast to previous studies, the number of circulating progenitor cells was not reduced in patients with chronic obstructive pulmonary disease compared with carefully matched controls.	24142520
Pulmonary Emphysema	Stem Cell Exhaustion	It seems unlikely that circulating endothelial progenitor cells or failure of angiogenesis plays a central role in the development of emphysema.	24142520
Graft-vs-Host Disease	Stem Cell Exhaustion	Steroid-refractory graft-versus-host disease is a life-threatening complication after allogeneic stem cell transplantation.	24142995
Frontotemporal dementia, Antilymphocyte Serum	Stem Cell Exhaustion	Here we sought to study altered molecular events in FTD and ALS by using induced pluripotent stem cell (iPSC) derived patient neurons.	24143176
Fanconi Anemia	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation in Fanconi anemia: the European Group for Blood and Marrow Transplantation experience.	24144640
Fanconi Anemia	Stem Cell Exhaustion	Although allogeneic hematopoietic stem cell transplantation (HSCT) remains the only curative treatment for patients with Fanconi anemia (FA), published series mostly refer to single-center experience with limited numbers of patients.	24144640
Adverse Event Associated with Secondary Malignancy, Chronic graft-versus-host disease	Stem Cell Exhaustion	Age more than 10 years at time of HSCT, clonal evolution as an indication for transplantation, peripheral blood as source of stem cells, and chronic graft-versus-host disease were found to be independently associated with the risk for secondary malignancy.	24144640
NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology	Stem Cell Exhaustion	Stem cell self-renewal factors Bmi1 and HMGA2 in head and neck squamous cell carcinoma: clues for diagnosis.	24145240
Neoplasms	Stem Cell Exhaustion	Both Bmi-1 and Hmga2 are known to promote stem cell self-renewal by negatively regulating the expressions of Ink4a and Arf tumor suppressors.	24145240
Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology	Stem Cell Exhaustion	Head and neck squamous cell carcinoma (HNSCC) includes both morphological and functional cellular heterogeneity, as would be expected if it arose from dysregulated stem or progenitor cells as opposed to the simple clonal expansion of a mutated cell; however, stemness molecule expression levels and distribution in HNSCC remain unclear.	24145240
Amyloidosis	Stem Cell Exhaustion	On multivariate analysis, pooled AL-CRAB and AL-PCMM retained negative prognostic value independent of age, Mayo Clinic AL amyloidosis stage, prior autologous stem-cell transplantation, and difference between the involved and uninvolved free light chain.	24145344
Cytomegalovirus Infections	Stem Cell Exhaustion	Clinical assessment of anti-viral CD8+ T cell immune monitoring using QuantiFERON-CMV(r) assay to identify high risk allogeneic hematopoietic stem cell transplant patients with CMV infection complications.	24146744
Zygomycosis, Hematologic Neoplasms	Stem Cell Exhaustion	Mucormycosis is increasingly encountered in immunosuppressed patients, such as those with haematological malignancies or stem cell transplantation.	24147728
Ameloblastoma	Stem Cell Exhaustion	Expression of the stem cell marker, SOX2, in ameloblastoma and dental epithelium.	24148099
Neoplasms	Stem Cell Exhaustion	Expression of the transcription factor SOX2 has been previously localized in epithelial stem and progenitor cells in developing teeth as well as in various tumors.	24148099
Ischemia, diabetic	Stem Cell Exhaustion	Role of serum levels of angiogenic cytokines in assessment of angiogenesis after stem cell therapy of diabetic patients with critical limb ischemia.	24148204
Parkinson Disease	Stem Cell Exhaustion	Parkinson's disease associated mutations in leucine rich repeat kinase 2 (LRRK2) impair mitochondrial function and increase the vulnerability of induced pluripotent stem cell (iPSC)-derived neural cells from patients to oxidative stress.	24148854
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Stratification of de novo adult acute myelogenous leukemia with adverse-risk karyotype: can we overcome the worse prognosis of adverse-risk group acute myelogenous leukemia with hematopoietic stem cell transplantation?	24149098
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Adverse-risk karyotype AML is now treated with intensive chemotherapy followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT) to overcome relapse.	24149098
Gastric Intestinal-Type Adenocarcinoma	Stem Cell Exhaustion	To investigate expression of stem cell marker Musashi-1 (Msi-1) in relationship to tumorigenesis and progression of intestinal-type gastric cancer (GC).	24151393
Lupus Erythematosus	Stem Cell Exhaustion	p53/p21 Pathway involved in mediating cellular senescence of bone marrow-derived mesenchymal stem cells from systemic lupus erythematosus patients.	24151513
Lupus Erythematosus, Adolescent Behavior, Encephalitis, St. Louis	Stem Cell Exhaustion	Our and other groups have found that bone marrow-derived mesenchymal stem cells (BM-MSCs) from systemic lupus erythematosus (SLE) patients exhibited senescent behavior and are involved in the pathogenesis of SLE.	24151513
Chronic myeloproliferative disorder, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myeloid leukemia (CML) on the contrary occurs in both young adults and elderly and is a chronic myeloproliferative disease that originates from abnormal pluripotent stem cells and results in involvement of multiple hematopoietic lineages, but predominantly myeloid and less commonly lymphoid.	24152491
Neoplasms, Glioblastoma	Stem Cell Exhaustion	Glioblastoma multiforme (GBM)-initiating cells (GICs) represent a tumor subpopulation with neural stem cell-like properties that is responsible for the development, progression and therapeutic resistance of human GBM.	24155920
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	We also examined the effect of AT13387 on putative cancer stem cells (CSC) by 3-D tumor sphere formation assay.	24156782
Liver carcinoma, Hollings Cancer Center	Stem Cell Exhaustion	Forfeited hepatogenesis program and increased embryonic stem cell traits in young hepatocellular carcinoma (HCC) comparing to elderly HCC.	24160375
Optic Nerve Hypoplasia	Stem Cell Exhaustion	Failure of stem cell therapy to improve visual acuity in children with optic nerve hypoplasia.	24160969
Optic Nerve Hypoplasia	Stem Cell Exhaustion	To evaluate the effectiveness of stem cell therapy in improving visual acuity or optic nerve function in children with optic nerve hypoplasia (ONH).	24160969
Teratoma	Stem Cell Exhaustion	No stem-cell-related teratoma formed and no anti-donor antibodies developed.	24161821
Chronic granulomatous disease	Stem Cell Exhaustion	Reduced-intensity conditioning and HLA-matched haemopoietic stem-cell transplantation in patients with chronic granulomatous disease: a prospective multicentre study.	24161820
Graft-vs-Host Disease, Chronic granulomatous disease	Stem Cell Exhaustion	In chronic granulomatous disease allogeneic haemopoietic stem-cell transplantation (HSCT) in adolescents and young adults and patients with high-risk disease is complicated by graft-failure, graft-versus-host disease (GVHD), and transplant-related mortality.	24161820
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation after conditioning with yttrium-90 ibritumomab tiuxetan plus BEAM in refractory non-Hodgkin diffuse large B-cell lymphoma: results of a prospective, multicenter, phase II clinical trial.	24162789
Retinal Diseases, Vascular Diseases	Stem Cell Exhaustion	The generation of vascular progenitors (VPs) from human induced pluripotent stem cells (hiPSCs) has great potential for treating vascular disorders such as ischemic retinopathies.	24163065
Failure, Myelodysplastic-Myeloproliferative Diseases	Stem Cell Exhaustion	Relapse is the major cause of treatment failure after allogeneic stem-cell transplantation (AHSCT) for patients with myelodysplastic syndrome/myeloproliferative syndrome neoplasms (MDS/MPN).	24164563
Aggressive course, Post-transplant lymphoproliferative disorder, Communicable Diseases	Stem Cell Exhaustion	Post-transplant lymphoproliferative disorder (PTLD) is a well-recognized aggressive disease commonly associated with Epstein-Barr virus (EBV) infection after hematopoietic stem cell transplantation (HSCT).	24169729
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	The efficacy of autologous stem-cell transplantation during the first remission in patients with diffuse, aggressive non-Hodgkin's lymphoma classified as high-intermediate risk or high risk on the International Prognostic Index remains controversial and is untested in the rituximab era.	24171516
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	While current treatment for acute myeloid leukemia is characterized by high response rates, patients' long-term outcome is still disappointing, due to frequent relapse and ineligibility of the often elderly patients for stem cell transplantation approaches.	24175978
Prostate carcinoma	Stem Cell Exhaustion	Atorvastatin inhibited Rho-associated kinase 1 (ROCK1) and focal adhesion kinase (FAK) mediated adhesion and differentiation of CD133+CD44+ prostate cancer stem cells.	24177008
Coronary Arteriosclerosis	Stem Cell Exhaustion	These associations remained after correction for factors known to affect progenitor cell levels including age, smoking status, the use of statin medications and the presence of coronary artery disease.	24182349
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Circulating hematopoietic progenitor cells are decreased in COPD.	24182349
Chronic Obstructive Airway Disease, Pulmonary Emphysema	Stem Cell Exhaustion	The goal of this study was to measure circulating levels of endothelial progenitor cells (EPCs) and hematopoietic progenitor cells (HPCs) in subjects with COPD and to determine if progenitor levels correlated with disease severity and the presence of emphysema.	24182349
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We present the results of a novel conditioning regimen in multiple myeloma (MM) patients undergoing tandem autologous stem cell transplant (ASCT).	24182816
Prostate carcinoma	Stem Cell Exhaustion	Expression of prostate stem cell antigen (PSCA) in prostate cancer: a tissue microarray study of Iranian patients.	24183365
Prostate carcinoma, prostate stem cell antigen	Stem Cell Exhaustion	Proteins expressed in prostate cancer, including prostate stem cell antigen (PSCA), have been investigated as biomarkers for diagnosis and therapy of prostate cancer.	24183365
Bacteremia, Thrombosis	Stem Cell Exhaustion	Incidence of and risk factors for persistent gram-positive bacteraemia and catheter-related thrombosis in haematopoietic stem cell transplantation.	24185587
Multiple Myeloma	Stem Cell Exhaustion	Phase 2 trial of intravenously administered plerixafor for stem cell mobilization in patients with multiple myeloma following lenalidomide-based initial therapy.	24185588
Multiple Myeloma	Stem Cell Exhaustion	Initial therapy of multiple myeloma with lenalidomide-based regimens can compromise stem cell collection, which can be overcome with the addition of plerixafor.	24185588
Fibrosis Assessment, leukemia	Stem Cell Exhaustion	Bone marrow fibrosis predicted an inferior overall survival and leukemia event-free survival for patients who received no hematopoietic stem cell transplant in univariate and multivariate analysis.	24186132
bone marrow fibrosis	Stem Cell Exhaustion	Eleven patients with bone marrow fibrosis and 32 control group patients underwent hematopoietic stem cell transplant; and bone marrow fibrosis was an independent risk for an inferior overall survival but not leukemia-free survival.	24186132
Myeloid, Histiocytosis, Langerhans-Cell, Acute leukemia	Stem Cell Exhaustion	Furthermore, these cases of acute myeloid or acute leukemia of ambiguous lineage with Langerhans cell histiocytosis share some unique features suggesting a common underlying neoplastic hematopoietic stem cell.	24186134
Hematologic Neoplasms, Neoplasms, Immunocompromised Host	Stem Cell Exhaustion	The most severely immunocompromised patients are those who have been diagnosed with a hematologic malignancy, solid organ tumor, or who have other conditions that require immunosuppressive therapies and/or solid organ or stem cell transplants.	24186906
Stricture of artery, Cerebrovascular accident	Stem Cell Exhaustion	Higher numbers of circulating endothelial progenitor cells in stroke patients with intracranial arterial stenosis.	24188156
Atherosclerosis	Stem Cell Exhaustion	Numbers of circulating endothelial progenitor cells (cEPCs) are associated with atherosclerosis.	24188156
Paroxysmal nocturnal hemoglobinuria, Hemolysis (lab result), Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH) is a hemolytic, clonal and acquired disorder of the hematopoietic stem cell with a deficiency of all glycophosphatidyl-inositol (GPI) linked proteins.	24188430
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	The role of interim fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) to guide use of upfront high dose chemotherapy (HDCT) and autologous stem cell transplant (ASCT) for patients with poor prognosis DLBCL is unproven.	24188476
Ductal Breast Carcinoma	Stem Cell Exhaustion	Clinicopathological analysis of breast ductal carcinoma in situ with ALDH1-positive cancer stem cells.	24192633
Noninfiltrating Intraductal Carcinoma, Specialty Type - cancer, Ductal Breast Carcinoma	Stem Cell Exhaustion	The aim of this study was to elucidate the clinicopathological characteristics of breast ductal carcinomas in situ (DCIS) with aldehyde dehydrogenase 1 (ALDH1)-positive cancer stem cells (CSCs).	24192633
Herpes Simplex Infections	Stem Cell Exhaustion	Transduction of SV40 and herpes simplex virus thymidine kinase-IRES-green fluorescent protein (TK-GFP) did not cause significant change in the stem cell properties of hfBMSCs.	24199592
Malignant neoplasm of brain, Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells have been isolated from malignant brain tumors and it is widely believed they arise from transformed endogenous stem cells.	24199814
Thrombophilia, Hemolysis (biological function), Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0, Non-Malignant	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired, nonmalignant disorder of hematopoietic stem cells characterized by hemolysis, diminished hematopoiesis, and thrombophilia.	24200143
Hematologic Neoplasms	Stem Cell Exhaustion	Elevated levels of serum ferritin have been documented to be an adverse prognostic factor in patients with hematologic malignancies undergoing hematopoietic stem cell transplantation.	24200518
Neoplasms, Specialty Type - cancer, Squamous cell carcinoma of esophagus	Stem Cell Exhaustion	In this study, we isolated cancer stem-like cells from an esophageal squamous cell carcinoma cell line EC109 based on aldehyde dehydrogenase 1A1 (ALDH1A1), and found that ALDH1A1(high) cells possessed the capacities of self-renewal, differentiation and tumor initiation, indications of stem cell properties.	24201124
Chronic myeloproliferative disorder, Primary Myelofibrosis	Stem Cell Exhaustion	Allogeneic stem cell transplantation for myelofibrosis with leukemic transformation: a study from the Myeloproliferative Neoplasm Subcommittee of the CMWP of the European Group for Blood and Marrow Transplantation.	24201159
Primary Myelofibrosis, Acute leukemia	Stem Cell Exhaustion	We identified 46 of 1048 myelofibrosis patients in the European Group for Blood and Marrow Transplantation registry who received allogeneic stem cell transplantation for acute leukemia evolving from myelofibrosis.	24201159
Primary Myelofibrosis, leukemia	Stem Cell Exhaustion	Allogeneic stem cell transplantation can cure myelofibrosis patients transformed to leukemia.	24201159
Glioblastoma Multiforme Pathway, Astrocytoma	Stem Cell Exhaustion	Nestin, a neural stem cell marker, was specifically expressed in astrocytoma lineage cells in glioma tissue.	24202294
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Clinicopathological significance of expression of nestin, a neural stem/progenitor cell marker, in human glioma tissue.	24202294
Acute leukemia	Stem Cell Exhaustion	Increased hs-cTnT levels occur in a significant proportion of adult survivors of childhood acute leukaemias and are associated with larger cumulative anthracycline dose received, history of leukaemic relapse, stem cell transplant, and cardiac irradiation, genetic variants in free radical metabolism, and worse LV myocardial deformation.	24204736
Specialty Type - cancer, Refractory Cytopenia of Childhood	Stem Cell Exhaustion	The genes identified as differentially methylated implicate pathways involved in metabolism, tissue response to injury, epithelial to mesenchymal transition (EMT), signal transduction and G-protein coupled receptors (GPCRs), cancer, and stem cell regulation in the biology of RCC.	24204800
Specialty Type - cancer	Stem Cell Exhaustion	Human bone marrow mesenchymal stem cells induce collagen production and tongue cancer invasion.	24204919
Secondary Neoplasm, Carcinoma	Stem Cell Exhaustion	Carcinoma-associated fibroblasts, bone marrow-derived multipotent mesenchymal stem cells (BMMSCs), and inflammatory cells can all affect the composition of TME leading to changes in proliferation, invasion and metastasis formation of carcinoma cells.	24204919
Thrombosis	Stem Cell Exhaustion	Cordocytes-stem cells cooperation in the human brain with emphasis on pivotal role of cordocytes in perivascular areas of broken and thrombosed vessels.	24205927
Vascular System Injuries	Stem Cell Exhaustion	This is the first cytohistopathological study which illustrates and explains some facets of cordocytes-stem cells cooperation around the vessels of human brain with emphasis on the fundamental role of cordocytes in response to vascular injuries.	24205927
leukemia, B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1	Stem Cell Exhaustion	Improving results of autologous stem cell transplantation for Philadelphia-positive acute lymphoblastic leukaemia in the era of tyrosine kinase inhibitors: a report from the Acute Leukaemia Working Party of the European Group for Blood and Marrow Transplantation.	24210524
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Guidelines for the management of symptomatic multiple myeloma (MM) recommend upfront autologous stem cell transplantation (ASCT) for transplant-eligible patients.	24210724
Allogeneic Hematopoietic Stem Cell Transplantation, herpesvirus 3, human	Stem Cell Exhaustion	Prophylactic role of long-term ultra-low-dose acyclovir for varicella zoster virus disease after allogeneic hematopoietic stem cell transplantation.	24211377
varicella zoster, herpesvirus 3, human	Stem Cell Exhaustion	To evaluate the prophylactic role of long-term ultra-low-dose acyclovir for varicella zoster virus (VZV) disease after allogeneic hematopoietic stem cell transplantation (HSCT).	24211377
Amyloidosis	Stem Cell Exhaustion	The combination of oral melphalan and dexamethasone is considered standard therapy for patients with light-chain amyloidosis ineligible for autologous stem cell transplantation.	24213149
Lupus Erythematosus, HIV Infections	Stem Cell Exhaustion	The incidence of HZ was highest among patients with bone marrow or stem cell transplant (43.03 %) followed by solid organ transplant, human immunodeficiency virus infection, and systemic lupus erythematosus [95 % confidence interval (CI) 15.19-17.41 %].	24214127
Chronic Lymphocytic Leukemia, Chronic graft-versus-host disease	Stem Cell Exhaustion	High incidence of chronic graft-versus-host disease after myeloablative allogeneic stem cell transplantation for chronic lymphocytic leukemia in Sweden: graft-versus-leukemia effect protects against relapse.	24214180
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (allo-SCT) is a potentially curative treatment option for eligible patients with chronic lymphocytic leukemia (CLL).	24214180
Multiple Myeloma	Stem Cell Exhaustion	High incidence of post-transplant cytomegalovirus reactivations in myeloma patients undergoing autologous stem cell transplantation after treatment with bortezomib-based regimens: a survey from the Rome transplant network.	24215479
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The incidence of cytomegalovirus (CMV) reactivations in patients with multiple myeloma (MM) receiving autologous stem cell transplantation (ASCT) is relatively low.	24215479
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Safety and effectiveness of the Genous(tm) endothelial progenitor cell-capture stent in the first year following ST-elevation acute myocardial infarction: A single center experience and review of the literature.	24216000
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Long-term outcomes of alemtuzumab-based reduced-intensity conditioned hematopoietic stem cell transplantation for myelodysplastic syndrome and acute myelogenous leukemia secondary to myelodysplastic syndrome.	24216184
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HSCT) with reduced-intensity conditioning (RIC) offers a potential cure for patients with myelodysplastic syndrome (MDS) who are ineligible for standard-intensity regimens.	24216184
PAFAH1B1 wt Allele, Malignant Neoplasms, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are age-dependent stem cell malignancies that share biological features of activated adaptive immune response and ineffective hematopoiesis.	24216507
CLU protein, human	Stem Cell Exhaustion	BM biopsies were obtained from patients with CLI (n=33) included in the Rejuvenating Endothelial Progenitor Cells via Transcutaneous Intra-arterial Supplementation (JUVENTAS) trial (NCT00371371) and controls (n=12).	24218170
Multiple Myeloma	Stem Cell Exhaustion	Differential humoral responses against heat-shock proteins after autologous stem cell transplantation in multiple myeloma.	24218189
Monoclonal Gammopathy of Undetermined Significance, Gammopathy	Stem Cell Exhaustion	The aim of the present study was to ascertain the serum antibody levels against three HSP (60, 70 and 90) by ELISA in patients with MM in complete remission after autologous stem cell transplantation (ASCT), with or without OB, and compare them with those patients with stable gammopathy of undetermined significance (MGUS) and healthy controls.	24218189
Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	The hemophagocytic syndrome(HPS) after the hematopoietic stem cell transplantation(SHCT) may be triggered by the reactivation of virus such as Epstein-Barr virus (EBV) or cytomegalovirus (CMV) under immunosuppressive state.	24218764
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Morphology, differentiation and adhesion molecule expression changes of bone marrow mesenchymal stem cells from acute myeloid leukemia patients.	24220608
Rheumatoid Arthritis	Stem Cell Exhaustion	Effect of therapeutic inhibition of TNF on circulating endothelial progenitor cells in patients with rheumatoid arthritis.	24222719
Rheumatoid Arthritis	Stem Cell Exhaustion	Low circulating endothelial progenitor cells (EPCs) have been described in many conditions associated with increased cardiovascular risk, including RA.	24222719
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukemia (AML) is believed to arise from leukemic stem-like cells (LSC) making understanding the biological differences between LSC and normal stem cells (HSC) or common myeloid progenitors (CMP) crucial to understanding AML biology.	24223100
Multiple Myeloma	Stem Cell Exhaustion	Upregulation of miR-135b is involved in the impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients.	24223191
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Previous studies have demonstrated that mesenchymal stem cells from multiple myeloma (MM) patients (MM-hMSCs) display a distinctive gene expression profile, an enhanced production of cytokines and an impaired osteogenic differentiation ability compared to normal donors (ND-hMSCs).	24223191
Autistic Disorder	Stem Cell Exhaustion	Etomidate with or without flumazenil anesthesia for stem cell transplantation in autistic children.	24225126
Autistic Disorder	Stem Cell Exhaustion	Forty autistic children aged 2-12, who were scheduled for stem cell transplantation via lumbar puncture under anesthesia, were randomized for a double-blind study.	24225126
Autistic Disorder	Stem Cell Exhaustion	Etomidate resulted in stable hemodynamic responses and relatively less adverse effects, and flumazenil antagonized the anesthetic effect of etomidate; thus, etomidate with flumazenil is suitable for performing stem cell transplantation in autistic children.	24225126
Autistic Disorder	Stem Cell Exhaustion	The aim of this study was to investigate etomidate administration with or without flumazenil in autistic children who underwent intrathecal transplantation of stem cells by lumbar puncture.	24225126
Intravascular hemolysis, Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH), a rare clonal hematopoietic stem cell disorder, is characterized by chronic, uncontrolled complement activation leading to intravascular hemolysis and an inflammatory prothrombotic state.	24227693
X-linked sideroblastic anemia, Malignant Neoplasms	Stem Cell Exhaustion	ZFX (zinc finger transcription factor, X chromosome-linked) contributes to the maintenance of different types of stem cells and the progression of various cancers.	24228108
Xerostomia	Stem Cell Exhaustion	Human salivary gland stem cells ameliorate hyposalivation of radiation-damaged rat salivary glands.	24232257
Infection of foot, diabetic	Stem Cell Exhaustion	Negative-pressure wound therapy induces endothelial progenitor cell mobilization in diabetic patients with foot infection or skin defects.	24232261
Neoplasms	Stem Cell Exhaustion	Notch signaling plays a role in stem cell biology, tumor formation, angiogenesis, and cell death.	24238845
Hematopoietic stem cells, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are pre-leukaemic haematopoietic stem cell disorders.	24238921
Hodgkin Disease	Stem Cell Exhaustion	Roughly 70-80% of patients with advanced stage Hodgkin's lymphoma are cured with various first-line and second-line treatments, including ABVD, BEACOPP, and stem-cell transplantation.	24239220
Retinal Dystrophies, Retinal Degeneration	Stem Cell Exhaustion	Transplantation of human bone marrow mesenchymal stem cells as a thin subretinal layer ameliorates retinal degeneration in a rat model of retinal dystrophy.	24239509
Hematologic Neoplasms	Stem Cell Exhaustion	In this retrospective single center study of 442 patients with hematologic malignancies, we analyzed prognostic factors for long-term survival after peripheral blood stem cell transplantation from HLA-matched related or unrelated donors.	24241489
Acute GVH disease, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Intentional donor lymphocyte-induced limited acute graft-versus-host disease is essential for long-term survival of relapsed acute myeloid leukemia after allogeneic stem cell transplantation.	24241493
Colorectal Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	CD133 has been recently identified as a marker of putative cancer stem cells in colorectal tumors.	24244031
Specialty Type - cancer	Stem Cell Exhaustion	The ability of cancer stem cells to resist chemotherapy was clinically highlighted; however, whether CD133 expression can predict chemoresistance remains controversial.	24244031
Liver carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Lin28B is an oncofetal circulating cancer stem cell-like marker associated with recurrence of hepatocellular carcinoma.	24244607
Specialty Type - cancer, Hollings Cancer Center	Stem Cell Exhaustion	Therefore, we sought to verify oncofetal-stemness characters of Lin28B and test its potential as a circulating cancer stem cell-like marker in adult HCC patients.	24244607
Neoplasms, Hollings Cancer Center	Stem Cell Exhaustion	In conclusion, the oncofetal gene Lin28B is a potential oncofetal cancer-stem-cell-like circulating tumor cell marker that correlates with HCC recurrence after hepatectomy.	24244607
Specialty Type - cancer	Stem Cell Exhaustion	It is also reported to be a potential marker for cancer stem cells.	24244607
Premature coronary artery atherosclerosis	Stem Cell Exhaustion	Early accelerated senescence of circulating endothelial progenitor cells in premature coronary artery disease patients in a developing country - a case control study.	24245738
Atherosclerosis, Coronary Arteriosclerosis	Stem Cell Exhaustion	The decreased number and senescence of circulating endothelial progenitor cells (EPCs) are considered markers of vascular senescence associated with aging, atherosclerosis, and coronary artery disease (CAD) in elderly.	24245738
Peripheral Arterial Diseases	Stem Cell Exhaustion	Effect of progenitor cell mobilization with granulocyte-macrophage colony-stimulating factor in patients with peripheral artery disease: a randomized clinical trial.	24247554
Ischemic cardiomyopathy	Stem Cell Exhaustion	To demonstrate the safety of transendocardial stem cell injection with autologous mesenchymal stem cells (MSCs) and bone marrow mononuclear cells (BMCs) in patients with ischemic cardiomyopathy.	24247587
physiopathological, Cardiomyopathies	Stem Cell Exhaustion	Transendocardial stem cell injection with MSCs or BMCs appeared to be safe for patients with chronic ischemic cardiomyopathy and LV dysfunction.	24247587
Ischemic cardiomyopathy	Stem Cell Exhaustion	Transendocardial mesenchymal stem cells and mononuclear bone marrow cells for ischemic cardiomyopathy: the TAC-HFT randomized trial.	24247587
Cardiomyopathies	Stem Cell Exhaustion	Whether culture-expanded mesenchymal stem cells or whole bone marrow mononuclear cells are safe and effective in chronic ischemic cardiomyopathy is controversial.	24247587
Coronary heart disease, altretamine/cisplatin/cyclophosphamide protocol	Stem Cell Exhaustion	Through investigating the effect of the angiotensin receptor blocker (ARB) losartan on the number of endothelial progenitor cells (EPCs) and blood flow-mediated endothelium-dependent function (FMD) in the peripheral blood of patients with coronary heart disease (CHD), we found that FMD was improved and the number of circulating EPCs increased in the ARB treatment group (P <0.05).	24247796
Specialty Type - cancer, Nasopharyngeal carcinoma	Stem Cell Exhaustion	Cancer stem cell characteristics, ALDH1 expression in the invasive front of nasopharyngeal carcinoma.	24248285
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Additionally, the features of cancer stem cells (CSCs) in the invasive front of tumors and its correlation with EMT also remain elusive.	24248285
Acute GVH disease	Stem Cell Exhaustion	Serum albumin level predicts survival of patients with gastrointestinal acute graft-versus-host disease after allogeneic stem cell transplantation.	24248672
Graft-vs-Host Disease	Stem Cell Exhaustion	Low serum albumin levels are associated with poorer OS in patients with gut but not skin aGVHD after RIC but not MAC allogeneic stem cell transplantation.	24248672
Multiple Myeloma	Stem Cell Exhaustion	Importance of achieving stringent complete response after autologous stem-cell transplantation in multiple myeloma.	24248686
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	To study the impact of achieving stringent complete response (sCR), an increasingly attainable goal, after autologous stem-cell transplantation (ASCT) in patients with multiple myeloma (MM).	24248686
Lymphoma	Stem Cell Exhaustion	False-Positive [18F]fluorodeoxyglucose-avid lymph nodes on positron emission tomography-computed tomography after allogeneic but not autologous stem-cell transplantation in patients with lymphoma.	24248697
Lymphoma	Stem Cell Exhaustion	Determine the clinical significance of [(18)F]fluorodeoxyglucose (FDG)-avid lesions in patients with lymphoma treated with stem-cell transplantation.	24248697
Lymphoma, Specialty Type - cancer	Stem Cell Exhaustion	All patients who underwent stem-cell transplantation for lymphoma at Memorial Sloan-Kettering Cancer Center between January 2005 and December 2009 and had post-transplantation FDG positron emission tomography/computed tomography (PET/CT) examinations were included.	24248697
Lymphoma	Stem Cell Exhaustion	Of allogeneic stem-cell transplantation recipients, 50 had FDG-avid lesions suggestive of lymphoma, defined as FDG-avidity greater than liver background.	24248697
Lymphoma	Stem Cell Exhaustion	Twenty percent (21 of 107) of patients with an allogeneic stem-cell transplantation demonstrated FDG-avid lymph nodes up to 1.5 cm in short axis on PET/CT, which did not represent active lymphoma.	24248697
Lymphoma, Malignant Neoplasms	Stem Cell Exhaustion	After allogeneic stem-cell transplantation of patients with lymphoma, benign FDG-avid <= 1.5 cm lymph nodes can mimic malignancy.	24248697
MYELODYSPLASTIC SYNDROME, Secondary Acute Myeloid Leukemia	Stem Cell Exhaustion	Long-term follow-up after allogeneic stem cell transplantation in patients with myelodysplastic syndromes or secondary acute myeloid leukemia: a single center experience.	24249320
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We performed a single center analysis of 60 adult patients (33 males and 27 females) with myelodysplastic syndromes (MDS) or secondary acute myeloid leukemia (AML) who underwent allogeneic hematopoietic stem cell transplantation (HCT) at our institution.	24249320
Viremia	Stem Cell Exhaustion	Donor T-cell chimerism and early post-transplant cytomegalovirus viremia in patients treated with myeloablative allogeneic hematopoietic stem cell transplant.	24251680
Communicable Diseases	Stem Cell Exhaustion	Cytomegalovirus (CMV) is a common infection after myeloablative allogeneic hematopoietic stem cell transplant (M-alloHSCT).	24251680
Sensorineural Hearing Loss (disorder), Dilated Cardiomyopathy Pathway, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 19-month-old girl with the A1555G mitochondrial mutation in the 12S ribosomal RNA gene and acute myelogenous leukemia developed dilated cardiomyopathy and bilateral sensorineural hearing loss before undergoing allogeneic stem cell transplantation.	24252789
fibrogenesis, Fibrosis Assessment	Stem Cell Exhaustion	The portal inflammatory infiltrate may contribute directly to fibrogenesis as well as influence the fate of the DR hepatic progenitor cells (HPCs), regulating the balance between liver repair and fibrosis.	24254368
diabetic	Stem Cell Exhaustion	Enhanced wound healing, kinase and stem cell marker expression in diabetic organ-cultured human corneas upon MMP-10 and cathepsin F gene silencing.	24255036
diabetic	Stem Cell Exhaustion	Our purpose was to assess if silencing M10 and CF in organ-cultured diabetic corneas using recombinant adenovirus (rAV)-driven small hairpin RNA (rAV-sh) would normalize slow wound healing, and diabetic and stem cell marker expression.	24255036
diabetic	Stem Cell Exhaustion	Diabetic, signaling, and putative stem cell markers were studied by immunofluorescence of corneal cryostat sections.	24255036
diabetic	Stem Cell Exhaustion	Small hairpin RNA silencing of proteinases overexpressed in diabetic corneas enhanced corneal epithelial and stem cell marker staining and accelerated wound healing.	24255036
emotional dependency, Adult Glioblastoma	Stem Cell Exhaustion	Protective properties of radio-chemoresistant glioblastoma stem cell clones are associated with metabolic adaptation to reduced glucose dependence.	24260384
Adult Glioblastoma, Neoplasms	Stem Cell Exhaustion	Glioblastoma stem cells (GSC) are a significant cell model for explaining brain tumor recurrence.	24260384
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	Stem Cell Exhaustion	Autologous haematopoietic stem cell transplantation: a viable treatment option for CIDP.	24262917
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	Stem Cell Exhaustion	Autologous haematopoietic stem cell transplantation (AHSCT) has been performed as a last treatment resort in a few therapy-refractory cases with CIDP.	24262917
Leukoencephalopathy	Stem Cell Exhaustion	Significant improvement following combination treatment with mefloquine and mirtazapine in a patient with progressive multifocal leukoencephalopathy after allogeneic peripheral blood stem cell transplantation.	24264833
Hypoxic-Ischemic Encephalopathy	Stem Cell Exhaustion	Therapeutic effect of human umbilical cord mesenchymal stem cells on neonatal rat hypoxic-ischemic encephalopathy.	24265136
Hypoxic-Ischemic Encephalopathy	Stem Cell Exhaustion	However, the possibility that human umbilical cord Wharton's jelly-derived mesenchymal stem cells (hUCMSCs) can be used to treat neonatal hypoxic-ischemic encephalopathy (HIE) has not yet been investigated.	24265136
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	There are no systematic data regarding nonmaintained induction for those patients with multiple myeloma (MM) who do not receive consolidative autologous stem cell transplantation.	24265187
Specialty Type - cancer	Stem Cell Exhaustion	Accumulating evidence suggests that the epigenome serves as the interface between the genome and the environment and that hypermethylation of stem cell polycomb group target genes is an epigenetic hallmark of cancer.	24265601
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Influence of ex vivo purging with CliniMACS CD34(+) selection on outcome after autologous stem cell transplantation in non-Hodgkin lymphoma.	24266323
Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	The major limitation of autologous stem cell transplantation (auto-SCT) in non-Hodgkin lymphoma (NHL) is relapse.	24266323
Amyloidosis	Stem Cell Exhaustion	Autologous stem cell transplant is an effective therapy for carefully selected patients with AL amyloidosis: experience of a single institution.	24266428
Amyloidosis	Stem Cell Exhaustion	Autologous stem-cell transplant has been widely used to treat patients with AL amyloidosis.	24266428
Amyloidosis	Stem Cell Exhaustion	In order to define the role of patient selection in stem cell transplantation, we evaluated 78 consecutive AL amyloidosis patients transplanted at our centre.	24266428
Mucopolysaccharidosis II, Mucopolysaccharidosis I	Stem Cell Exhaustion	All MPS patients had or were receiving treatment: 15 patients (6 MPS I, 9 MPS II) were receiving enzyme replacement therapy (ERT), 9 patients (all MPS I) had received hematopoietic stem cell transplant (HSCT), and 1 patient with MPS I had received HSCT and was receiving enzyme replacement therapy (ERT).	24268528
Diabetes, Autonomic neuropathy	Stem Cell Exhaustion	Diabetes causes bone marrow autonomic neuropathy and impairs stem cell mobilization via dysregulated p66Shc and Sirt1.	24270983
Diabetic Autonomic Neuropathy	Stem Cell Exhaustion	Diabetic autonomic neuropathy (DAN) may impact the BM, because the sympathetic nervous system is prominently involved in BM stem cell trafficking.	24270983
Diabetes, Ischemia, Neuropathy	Stem Cell Exhaustion	We hypothesize that neuropathy of the BM affects stem cell mobilization and vascular recovery after ischemia in patients with diabetes.	24270983
Autonomic neuropathy, Diabetes	Stem Cell Exhaustion	In conclusion, autonomic neuropathy in the BM impairs stem cell mobilization in diabetes with dysregulation of the life-span regulators p66Shc and Sirt1.	24270983
Diabetes, Autonomic neuropathy, Ischemia, Landau-Kleffner Syndrome	Stem Cell Exhaustion	Experimental diabetes (streptozotocin-induced and ob/ob mice) or chemical sympathectomy in mice resulted in BM autonomic neuropathy, impaired Lin(-)cKit(+)Sca1(+) (LKS) cell and endothelial progenitor cell (EPC; CD34(+)Flk1(+)) mobilization, and vascular recovery after ischemia.	24270983
Immune-mediated	Stem Cell Exhaustion	Immune-mediated neuropathies following stem cell transplantation.	24273223
Immune-mediated neuropathy	Stem Cell Exhaustion	To study the clinical, electrophysiological and pathological characteristics and outcome of immune-mediated neuropathy (IMN) following stem cell transplantation (SCT).	24273223
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Impact of prior rituximab on outcomes of autologous stem-cell transplantation in patients with relapsed or refractory aggressive B-cell lymphoma: a multicentre retrospective Spanish group of lymphoma/autologous bone marrow transplant study.	24274082
S100A4 protein, human, Fanconi Anemia	Stem Cell Exhaustion	Reports of oral malignant transformation in Fanconi Anemia after hematopoietic stem cell transplantation (HSCT) are increasing probably because of longer survival rates.	24274144
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Fatty acid binding protein 7 as a marker of glioma stem cells.	24274717
Adult Glioblastoma	Stem Cell Exhaustion	Glioblastoma stem cells (GSCs) are thought to be responsible for the recurrence, chemoresistance, and poor prognosis of glioblastoma.	24274717
Specialty Type - cancer	Stem Cell Exhaustion	This study investigates an expressive helping (EH) intervention designed to harness those benefits by targeting survivorship problems among cancer survivors treated with hematopoietic stem cell transplant.	24274798
Non-Malignant	Stem Cell Exhaustion	Nonmalignant disease and use of alternative hematopoietic stem cell transplantation were associated with higher risk of PICU admission.	24276033
Malignant neoplasm of pancreas, Specialty Type - cancer, Adult Glioblastoma	Stem Cell Exhaustion	In laboratory studies, metformin was reported to affect the survival of cancer stem cells (CSCs) in breast and pancreatic cancers and glioblastoma.	24278407
Secondary malignant neoplasm of pleura	Stem Cell Exhaustion	One patient with unilateral pleural metastases subsequently underwent hematopoietic stem cell transplantation.	24279977
Myocardial Ischemia	Stem Cell Exhaustion	Circulating endothelial progenitor cells and especially endothelial colony-forming cells (ECFCs) are promising candidate cells for endothelial regenerative medicine of ischemic diseases, but the conditions for an optimal collection from adult blood must be improved.	24280239
Malignant neoplasm of ovary, Malignant Neoplasms	Stem Cell Exhaustion	In summary, this research provides a plastic ovarian cancer stem cell model and a new understanding of the cross-link between stem cells and cancers.This results show that ovarian CSLCs can be suppressed by levamisole.	24280306
Specialty Type - cancer	Stem Cell Exhaustion	Spheroid formation is one property of stem cells-such as embryo-derived or neural stem cells-that has been used for the enrichment of cancer stem-like cells (CSLCs).	24280306
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Stem cell factor SALL4, a potential prognostic marker for myelodysplastic syndromes.	24283704
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Due to progress in the research of glioma stem cells and the glioma niche, development of an animal model that facilitates the elucidation of the roles of the host tissue and cells is necessary.	24284913
Glioblastoma Multiforme Pathway, Neoplasms	Stem Cell Exhaustion	Tumors derived from the human glioma stem/progenitor cell line SU3 were subcutaneously implanted in green fluorescent protein nude mice.	24284913
Glioblastoma Multiforme Pathway, Hemorrhagic, Necrosis, Neoplasms	Stem Cell Exhaustion	Green fluorescent protein nude mouse subcutaneous xenografts not only consistently maintained the high invasiveness and tumorigenicity of glioma stem/progenitor cells, but also consisted of a high concentration of tumor blood vessels and necrotic and hemorrhagic foci.	24284913
Sample Size Calculation	Stem Cell Exhaustion	The expression of EGFL7 in forearm skin biopsies (n = 16 SSc, n = 10 controls), cultured dermal microvascular endothelial cells (MVECs) (n = 3 SSc, n = 3 controls) and late-outgrowth peripheral blood endothelial progenitor cell (EPC)-derived endothelial cells (n = 15 SSc, n = 8 controls) was investigated by immunofluorescence and Western blotting.	24286167
Cartilage	Stem Cell Exhaustion	Injectable cultured bone marrow-derived mesenchymal stem cells in varus knees with cartilage defects undergoing high tibial osteotomy: a prospective, randomized controlled clinical trial with 2 years' follow-up.	24286801
Keratoconus	Stem Cell Exhaustion	Protection of corneal epithelial stem cells prevents ultraviolet A damage during corneal collagen cross-linking treatment for keratoconus.	24288393
Kidney Diseases, Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation	Stem Cell Exhaustion	[Complete remission of repeated recurrent membranous nephropathy after non-myeloablative allogeneic peripheral blood stem cell transplantation].	24288970
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	A 64-year-old man with treatment-related myelodysplastic syndrome (MDS) underwent non-myeloablative allogeneic peripheral blood stem cell transplantation from a fully HLA-matched sibling.	24288970
Usual Severity Pain, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Early application of percutaneous vertebroplasty reduces pain without affecting peripheral blood stem cell (PBSC) collection and transplant in newly diagnosed multiple myeloma (MM) patients.	24289239
Joints	Stem Cell Exhaustion	Safety reporting on implantation of autologous adipose tissue-derived stem cells with platelet-rich plasma into human articular joints.	24289766
Cessation of life, Edema	Stem Cell Exhaustion	However, swelling of injected joints was common and was thought to be associated with death of stem cells.	24289766
Cerebrovascular accident	Stem Cell Exhaustion	In the investigator-initiated clinical trial of stem cell therapy for stroke, we are going to include fine-grained evaluation methods and investigate the most suitable technique of rehabilitation for patients after treatment.	24291920
Cerebral Infarction	Stem Cell Exhaustion	[Rehabilitation for patients with cerebral infarction after transplantation of autologous human mesenchymal stem cells].	24291920
Cerebral Infarction	Stem Cell Exhaustion	We participated as physiatrists in Honmou et al's study that designed to assess feasibility and safety of transplantation of autologous human mesenchymal stem cells in patients with cerebral infarction, and tried to detect improvements that were distinguishable from usual course of rehabilitation.	24291920
Graft-vs-Host Disease	Stem Cell Exhaustion	Vorinostat plus tacrolimus and mycophenolate to prevent graft-versus-host disease after related-donor reduced-intensity conditioning allogeneic haemopoietic stem-cell transplantation: a phase 1/2 trial.	24295572
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease (GVHD) remains a barrier to more widespread application of allogeneic haemopoietic stem-cell transplantation.	24295572
Graft-vs-Host Disease	Stem Cell Exhaustion	We aimed to study the safety and activity of vorinostat, in combination with standard immunoprophylaxis, for prevention of GVHD in patients undergoing related-donor reduced-intensity conditioning haemopoietic stem-cell transplantation.	24295572
Hematological Disease, Hemopoietic stem cell transplant	Stem Cell Exhaustion	We recruited adults (aged >=18 years) with high-risk haematological malignant diseases who were candidates for reduced-intensity conditioning haemopoietic stem-cell transplantation and had an available 8/8 or 7/8 HLA-matched related donor.	24295572
Graft-vs-Host Disease	Stem Cell Exhaustion	Future studies are needed to assess the effect of vorinostat for prevention of GVHD in broader settings of haemopoietic stem-cell transplantation.	24295572
Secondary to, Multiple Myeloma	Stem Cell Exhaustion	Secondary MGUS was more common in patients with myeloma who had undergone stem cell transplantation than in those who had not (17 [29.8%] of 57 versus 5 [1.4%] of 352, P < .001).	24296491
Endothelial Progenitor Cells	Stem Cell Exhaustion	Glycogen synthase kinase-3b inhibition augments diabetic endothelial progenitor cell abundance and functionality via cathepsin B: a novel therapeutic opportunity for arterial repair.	24296714
Dominica, Diabetes Mellitus	Stem Cell Exhaustion	Progenitor cell therapy is hindered in patients with diabetes mellitus (DM) due to cellular senescence.	24296714
Dominica	Stem Cell Exhaustion	Thus, we aimed to determine if and how GSK3b inhibitors (GSKi) can improve therapeutic efficacy of endothelial progenitor cells (EPC) from patients with DM.	24296714
European Organization for Research and Treatment of Cancer, Global Stable Disease in Lymph Nodes, Specialty Type - cancer, leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The European Organisation for Research and Treatment of Cancer (EORTC) and Gruppo Italiano Malattie Ematologiche dell' Adulto (GIMEMA) Leukemia Groups conducted a randomized trial (AML-12; Combination Chemotherapy, Stem Cell Transplant and Interleukin-2 in Treating Patients With Acute Myeloid Leukemia) in 1,942 newly diagnosed patients with AML, age 15 to 60 years, comparing remission induction treatment containing daunorubicin, etoposide, and either standard-dose (SD) cytarabine (100 mg/m(2) per day by continuous infusion for 10 days) or high-dose (HD) cytarabine (3,000 mg/m(2) every 12 hours by 3-hour infusion on days 1, 3, 5, and 7).	24297940
Burn, CTCAE	Stem Cell Exhaustion	A 56-year-old man with a severe chemical burn was referred to our clinic for the management of total limbal stem cell deficiency.	24299729
Malignant neoplasm of ovary, Specialty Type - cancer	Stem Cell Exhaustion	Molecular portraits of heterogeneity related to cancer stem cells in human ovarian cancer.	24300467
Malignant neoplasm of ovary, Specialty Type - cancer	Stem Cell Exhaustion	The aim of this study was to investigate molecular portraits of heterogeneity related to cancer stem cells (CSCs) in human ovarian cancer and to access the value in diagnosis and treatment.	24300467
diabetic	Stem Cell Exhaustion	Differential MMP-9 activity in CD34+progenitor cell-derived foam cells from diabetic and normoglycemic patients.	24305990
diabetic	Stem Cell Exhaustion	We analyzed the growth characteristics as well as the M-CSF-release and matrix metalloproteinase (MMP) synthesis from CD34(+) progenitor cell-derived foam cells originating from diabetic and nondiabetic patients.	24305990
diabetic	Stem Cell Exhaustion	There is evidence that progenitor cells from diabetic and nondiabetic patients have different properties, which may affect the patients' prognosis.	24305990
diabetic	Stem Cell Exhaustion	CD34(+) progenitor cells from diabetic and nondiabetic patients were isolated and incubated with platelets from healthy volunteers.	24305990
Hypertensive (finding)	Stem Cell Exhaustion	Effect of olmesartan medoxomil on number and survival of circulating endothelial progenitor cells and calcitonin gene related peptide in hypertensive patients.	24309489
Endothelium, Vascular, Vascular Diseases	Stem Cell Exhaustion	Injury of vascular endothelium, crucial in vascular disease, is repaired via circulating endothelial progenitor cells (cEPCs).	24309489
Transglutaminases	Stem Cell Exhaustion	Immunohistochemical staining included Congo red, Oil Red O, periodic acid-Schiff (PAS), Masson's trichrome, transglutaminase-2 (TG-2), mesenchymal stem cell markers CD29 (b-1-integrin), and CD34.	24311926
Rheumatoid Arthritis, Inflammation, Atherosclerosis, Vascular lesions	Stem Cell Exhaustion	To evaluate the association between inflammation, oxidative stress, and circulating progenitor cell (CPC) number and redox equilibrium, vascular lesions and accelerated atherosclerosis in rheumatoid arthritis (RA).	24313545
Rheumatoid Arthritis, Inflammation	Stem Cell Exhaustion	Circulating progenitor cells in rheumatoid arthritis: association with inflammation and oxidative stress.	24313545
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	PFS was significantly influenced by CLL duration, beta2-microglobulin, and improved by post-remissional stem cell transplantation.	24314589
Late Onset Disorders	Stem Cell Exhaustion	Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) resets their identity back to an embryonic age and, thus, presents a significant hurdle for modeling late-onset disorders.	24315443
Chemosensitivity	Stem Cell Exhaustion	A phase II study of a nonmyeloablative allogeneic stem cell transplant with peritransplant rituximab in patients with B cell lymphoid malignancies: favorably durable event-free survival in chemosensitive patients.	24315843
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	The aim of this prospective phase II trial was to determine the safety and efficacy of a nonmyeloablative conditioning program incorporating peritransplant rituximab in patients with CD20+ B cell non-Hodgkin lymphoma (B-NHL) receiving an allogeneic stem cell transplant (allo-SCT).	24315843
Multiple Myeloma	Stem Cell Exhaustion	We conducted a retrospective evaluation of response and survival for 293 patients with multiple myeloma treated since June 2000 with primary thalidomide- or bortezomib-based combinations, of whom 207 patients received intensive therapy supported by autologous blood stem cells within the first year.	24317125
Neoplasm Metastasis, Hemopoietic stem cell transplant	Stem Cell Exhaustion	Secondary solid tumors that occur after hematopoietic stem cell transplantation (HSCT) are late complications of HSCT.	24317739
Neoplasms	Stem Cell Exhaustion	It means that circulating bone marrow-derived stem cells (BMDCs) including hematopoietic stem cells include the stem cells of many tissue types and the precancerous cells of many solid tumors.	24317739
Squamous cell carcinoma of esophagus	Stem Cell Exhaustion	This study suggests that BMDC-derived cells include the stem cells of esophageal epidermis and the precancerous cells of esophageal SCC and can differentiate into esophageal epithelium and esophageal SCC.	24317739
Have Been Vomiting, Nausea	Stem Cell Exhaustion	Palonosetron and dexamethasone for the prevention of nausea and vomiting in patients receiving allogeneic hematopoietic stem cell transplantation.	24317849
Have Been Vomiting, Nausea	Stem Cell Exhaustion	The primary aim of this study was to evaluate the efficacy of palonosetron combined with dexamethasone in the prevention of vomiting, and especially nausea, in patients receiving allogeneic stem cell transplantation.	24317849
Graft-vs-Host Disease	Stem Cell Exhaustion	The study emphasizes the importance of rs4693608 SNP for HPSE gene expression in activated MNCs, indicating a role in allogeneic stem cell transplantation, including postconditioning, engraftment, and GVHD.	24319286
Neoplasms	Stem Cell Exhaustion	Staining for BerEp4 was positive at the periphery of both neoplasms, suggesting germinative differentiation of the neoplastic cells, whereas staining for the follicular stem-cell marker PHLDA-1 (TDAG51) showed strong focal expression in the tumor cells of both cases.	24320809
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	In vitro data indicate that low doses of metformin inhibited the self-renewal/proliferation of cancer stem cells (CSC)/TICs in ErbB2-overexpressing breast cancer cells.	24322659
Infection, leukemia	Stem Cell Exhaustion	Targeted therapy against multi-resistant bacteria in leukemic and hematopoietic stem cell transplant recipients: guidelines of the 4th European Conference on Infections in Leukemia (ECIL-4, 2011).	24323984
Endometrial Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Epithelial-mesenchymal transition and cancer stem cells in endometrial cancer.	24324082
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Epithelial-mesenchymal transition (EMT) and cancer stem cells (CSCs) are presumed to be key conditions for malignancy.	24324082
Degenerative polyarthritis	Stem Cell Exhaustion	Stem cell injections combined with arthroscopic lavage were administered to 30 elderly patients (>=65 years) with knee OA.	24326779
Degenerative polyarthritis, Usual Severity Pain	Stem Cell Exhaustion	Adipose-derived stem cell therapy for elderly patients with knee OA was effective in cartilage healing, reducing pain, and improving function.	24326779
Degenerative polyarthritis	Stem Cell Exhaustion	Therefore, adipose-derived stem cell treatment appears to be a good option for OA treatment in elderly patients.	24326779
Degenerative polyarthritis	Stem Cell Exhaustion	Clinical results and second-look arthroscopic findings after treatment with adipose-derived stem cells for knee osteoarthritis.	24326779
Osteoarthritis, Knee, Degenerative polyarthritis	Stem Cell Exhaustion	In the present study, the clinical outcomes and second-look arthroscopic findings of intra-articular injection of stem cells with arthroscopic lavage for treatment of elderly patients with knee osteoarthritis (OA) were evaluated.	24326779
Specialty Type - cancer	Stem Cell Exhaustion	We investigated how cancer stem cell markers change after neoadjuvant therapy and how these markers relate to recurrence.	24327017
NES gene	Stem Cell Exhaustion	The stem cell marker nestin (NES) is found in dividing cells of developing and regenerating tissues.	24329895
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (auto-HSCT) is a promising approach for non-Hodgkin's lymphoma (NHL).	24329982
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	High-dose MTX is a powerful regimen component for stem cell mobilization in adult patients with NHL.	24329982
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	High-dose methotrexate in the mobilization of hematopoietic stem cells for patients with non-Hodgkin's lymphoma: a twelve-year study in a single center.	24329982
Down Syndrome	Stem Cell Exhaustion	The effect of imatinib on Ab production was also investigated in human embryonic kidney 293 (HEK293) cells overexpressing the amyloid precursor protein (APP) with the Swedish mutation, in mouse primary cortical neurons and in human Down syndrome embryonic stem-cell-derived cortical neurons.	24331439
Communicable Diseases	Stem Cell Exhaustion	Comparable humoral response after two doses of adjuvanted influenza A/H1N1pdm2009 vaccine or natural infection in allogeneic stem cell transplant recipients.	24333120
Hemopoietic stem cell transplant, Communicable Diseases	Stem Cell Exhaustion	The present study evaluated immunogenicity and tolerance of two-dose influenza A/H1N1pdm09 vaccination in allogeneic hematopoietic stem cell transplantation (HSCT) recipients, and compared the vaccine-induced humoral response to that triggered by natural infection in another group of HSCT patients.	24333120
Endometrial Carcinoma	Stem Cell Exhaustion	In vitro assay confirmed that stem cell factor (SCF), a ligand of CD117, was produced specifically in CD117(+) cells of endometrial cancer, and the colony-forming activity were abrogated by adding anti-SCF antibody, indicating an SCF-dependent growth property.	24333732
Coronary Arteriosclerosis	Stem Cell Exhaustion	Inverse correlation between circulating endothelial progenitor cells with CD34+CD133+ and the severity of coronary atherosclerosis assessed by Syntax score.	24335569
Atherosclerosis	Stem Cell Exhaustion	The number of endothelial progenitor cells (EPCs) descends when atherosclerosis developed.	24335569
Inflammation, Coronary Arteriosclerosis	Stem Cell Exhaustion	Effects of clopidogrel therapy on oxidative stress, inflammation, vascular function, and progenitor cells in stable coronary artery disease.	24336012
Arterial Stiffness, Inflammation, Hyperemia	Stem Cell Exhaustion	We assessed (1) endothelial function as flow-mediated dilation of the brachial artery, (2) arterial stiffness and central augmentation index using applanation tonometry, (3) vascular function as fingertip reactive hyperemia index, (4) inflammation by measuring plasma CD40 ligand and serum high-sensitivity c-reactive protein levels, (5) oxidative stress by measuring plasma aminothiols, and (6) circulating progenitor cells, at baseline and at the end of each 6-week treatment period.	24336012
Arterial Stiffness	Stem Cell Exhaustion	However, clopidogrel therapy had no effect on endothelial function, arterial stiffness, inflammatory and oxidative stress markers, or progenitor cells.	24336012
Myeloid Leukemia, Chronic, Ionizing radiation	Stem Cell Exhaustion	The incidence of chronic myeloid leukemia (CML), which is caused by BCR/ABL chimeric oncogene formation in a pluripotent hematopoietic stem cell (HSC), increases with age and exposure to ionizing radiation.	24337217
Mantle cell lymphoma	Stem Cell Exhaustion	Long-term clinical and molecular remissions in patients with mantle cell lymphoma following high-dose therapy and autologous stem cell transplantation.	24337447
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	Long-term clinical and molecular remissions in patients with mantle cell lymphoma (MCL) following high-dose therapy (HDT) and autologous stem cell transplantation (ASCT) have been evaluated in only a few studies.	24337447
B-Cell Lymphomas, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	High-dose chemotherapy (HDT), together with autologous stem cell transplantation (ASCT), plays an important role in the treatment of diffuse large B cell lymphoma (DLBCL), especially as second-line therapy.	24338743
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Impact of postremission consolidation chemotherapy on outcome after reduced-intensity conditioning allogeneic stem cell transplantation for patients with acute myeloid leukemia in first complete remission: a report from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation.	24338939
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The objective of the current study was to investigate the role of postremission consolidation chemotherapy before reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (alloSCT) for patients with acute myeloid leukemia (AML) in first complete remission (CR1).	24338939
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Of the 789 consecutive patients with AML in CR1 who underwent RIC alloSCT from a human leukocyte antigen-matched sibling or matched unrelated donor peripheral stem cell grafts between 2001 and 2010, 591 patients received at least 1 cycle of consolidation chemotherapy and 198 patients did not receive any consolidation chemotherapy before alloSCT.	24338939
Vascular System Injuries	Stem Cell Exhaustion	Circulating endothelial cells (CEC) may be a biomarker of vascular injury and pro-thrombotic tendency, while circulating endothelial progenitor cells (CEP) may be an indicator for angiogenesis and vascular remodelling.	24339944
Ependymal cell	Stem Cell Exhaustion	Substantial ependymal cell loss resulted in reactive gliosis rather than stem cell-mediated regenerative repair of the ventricle lining, and the gliotic regions showed morphologic and phenotypic characteristics similar to those found in aged humans.	24341850
Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy and autologous stem cell transplantation in multiple myeloma: a single institution experience at All India Institute of Medical Sciences, New Delhi, using non-cryopreserved peripheral blood stem cells.	24342104
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation (AHCT) improves survival in patients with multiple myeloma (MM) but is associated with morbidity and nonrelapse mortality (NRM).	24342394
Multiple Myeloma	Stem Cell Exhaustion	The effect of gradual increment in rhG-CSF dose on stem cell yields in patients with multiple myeloma mobilized with intermediate dose cyclophosphamide plus rhG-CSF.	24342458
Peripheral Blood Stem Cells, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	In this paper, we aimed to present gradual dose increment of rhG-CSF between the third day of mobilization and time to apheresis that is started with 5 mg/kg (from day 3 to day 7) and continued with 10 mg/kg (from day 8 to time to apheresis) for peripheral blood stem cell (PBSC) mobilization in multiple myeloma (MM) patients and its effect on stem cell yield and mobilization success.	24342458
Malignant neoplasm of ovary	Stem Cell Exhaustion	Immunohistochemical expression and prognostic relevance of Bmi-1, a stem cell factor, in epithelial ovarian cancer.	24342665
Malignant Neoplasms	Stem Cell Exhaustion	Bmi-1 is a stem cell factor implicated in many human malignancies with poor outcome.	24342665
Medial collateral ligament	Stem Cell Exhaustion	To examine the outcomes of patients with chemotherapy-sensitive mantle-cell lymphoma (MCL) following a first hematopoietic stem-cell transplantation (HCT), comparing outcomes with autologous (auto) versus reduced-intensity conditioning allogeneic (RIC allo) HCT and with transplantation applied at different times in the disease course.	24344210
Kidney Failure, Chronic, Chronic kidney disease stage 5	Stem Cell Exhaustion	We present a 29-year-old male with end stage renal disease (ESRD) who was transplanted with HLA 4/6 matched kidney from 51-year-old father in June 2010 preceded by co-infusion of donor-adipose tissue derived mesenchymal stem cells (AD-MSC) and bone marrow derived hematopoietic stem cells (BM-HSC) under non-myeloablative conditioning for deleting rejecting T and B-cells.	24344734
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	Putative stem cell markers in non-small-cell lung cancer: a clinicopathologic characterization.	24346092
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	The cancer stem cell (CSC) theory postulates the existence of a distinct population of undifferentiated cells responsible for tumor initiation and maintenance.	24346092
Specialty Type - cancer	Stem Cell Exhaustion	Proposed CSC markers are expressed both by cancer cells as well as by benign stem cells.	24346092
Angina Pectoris	Stem Cell Exhaustion	We investigated atorvastatin reloading effects on endothelial progenitor cell (EPC) count and inflammatory cytokine expression after percutaneous coronary intervention (PCI) in patients with stable angina pectoris who had previously received long-term statin treatments.	24346155
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Monitoring of acute myeloid leukemia patients after allogeneic stem cell transplantation employing semi-automated CD34+ donor cell chimerism analysis.	24352219
Malignant Neoplasms	Stem Cell Exhaustion	We investigated the long-term risks for systemic and site-specific cancers in patients who had received autologous bone marrow-derived stromal progenitor cells to treat orthopaedic lesions.	24352775
Specialty Type - cancer	Stem Cell Exhaustion	This study found no increased cancer risk in patients after application of autologous cell-based therapy using bone marrow-derived stromal progenitor cells either at the treatment site or elsewhere in the patients after an average follow-up period of 12.5 years.	24352775
Multiple Myeloma	Stem Cell Exhaustion	Oligoclonal and monoclonal bands after single autologous stem cell transplant in patients with multiple myeloma: impact on overall survival and progression-free survival.	24354684
Multiple Myeloma	Stem Cell Exhaustion	Abstract Recently, the occurrence of oligoclonal and monoclonal bands (OB/MB) unrelated to the original clone has been reported in patients with multiple myeloma who undergo autologous stem cell transplant (ASCT) and/or receive treatment with novel agents.	24354684
Pneumonia	Stem Cell Exhaustion	The availability of HEPA-filtered rooms and the incidence of pneumonia in patients after haematopoietic stem cell transplantation (HSCT): results from a prospective, multicentre, eastern European study.	24354726
Pneumonia	Stem Cell Exhaustion	To establish the availability of High Efficiency Particulate Air (HEPA)- and nonHEPA-filtered rooms in eastern European transplant centres and to investigate the impact on incidence of pneumonia and mortality after haematopoietic stem cell transplantation (HSCT).	24354726
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation for elderly patients with newly diagnosed multiple myeloma in the era of novel agents.	24356629
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	High-dose therapy (HDT) with autologous stem cell transplantation (ASCT) is considered the standard of care for multiple myeloma (MM) patients <65 years.	24356629
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	The impact of allogeneic stem cell transplantation on the natural course of poor-risk chronic lymphocytic leukemia as defined by the EBMT consensus criteria: a retrospective donor versus no donor comparison.	24356631
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	In a single-center retrospective donor versus no-donor comparison, we investigated if allogeneic stem cell transplantation (alloSCT) can improve the dismal course of poor-risk chronic lymphocytic leukemia (CLL).	24356631
Diabetic foot ulcer	Stem Cell Exhaustion	Role of endothelial progenitor cells and inflammatory cytokines in healing of diabetic foot ulcers.	24358275
Foot Ulcer	Stem Cell Exhaustion	To evaluate changes in endothelial progenitor cells (EPCs) and cytokines in patients with diabetic foot ulceration (DFU) in association with wound healing.	24358275
Lymphoma	Stem Cell Exhaustion	[Clinical investigation of refractory lymphoma with HLA-mismatched stem-cell microtransplantation].	24360103
Lymphoma	Stem Cell Exhaustion	To explore the efficacy and safety of HLA-mismatched stem-cell microtransplantation in patients with refractory lymphoma.	24360103
Graft-vs-Host Disease	Stem Cell Exhaustion	All patients received programmed infusions of G-CSF-mobilized HLA-mismatched donor peripheral blood stem cell (G-PBSC) after each cycle of Hyper-CVAD/MA conditioning without graft-versus-host disease (GVHD) prophylaxis.	24360103
Osteogenesis	Stem Cell Exhaustion	Osteogenic lineage commitment of mesenchymal stem cells from patients with ossification of the posterior longitudinal ligament.	24361881
Osteogenesis	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) were isolated from spinal ligaments and shown to play a key role in the process of ectopic ossification.	24361881
Triclonal gammopathy	Stem Cell Exhaustion	After bone marrow biopsy, MM with triclonal gammopathy was diagnosed and autologous stem cell transplantation was performed.	24361990
Specialty Type - cancer, Triple-Negative Breast Cancer Finding	Stem Cell Exhaustion	Nuclear localization of cancer stem cell marker CD133 in triple-negative breast cancer: a case report.	24362879
Neoplasms, Triple-Negative Breast Cancer Finding, Childhood Breast Carcinoma	Stem Cell Exhaustion	It has been recently demonstrated that the detection of stem cell niches in triple-negative (TN) breast cancer may provide good prognostic clues for this tumor.	24362879
Specialty Type - cancer, Childhood Breast Carcinoma, Ductal Breast Carcinoma	Stem Cell Exhaustion	We investigated the subcellular expression and localization of the cancer stem cell marker CD133 in a TN breast cancer biopsy from a 42-year-old Caucasian woman with a histological diagnosis of high-grade invasive ductal breast carcinoma by immunohistochemistry, flow cytometry and quantitative real-time PCR (qRT-PCR).	24362879
Liver Failure, Acute	Stem Cell Exhaustion	Proliferation of mouse liver stem/progenitor cells induced by plasma from patients with acute liver failure is modulated by P2Y2 receptor-mediated JNK activation.	24362969
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Monoclonal antibody targeting of IL-3 receptor a with CSL362 effectively depletes CML progenitor and stem cells.	24363400
Leukemia, Myelocytic, Acute, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We evaluated the expression of the interleukin 3 (IL-3) receptor a subunit (CD123), an established marker of acute myeloid leukemia stem cells, on CML LSPCs and the potential of targeting those cells with the humanized anti-CD123 monoclonal antibody CSL362.	24363400
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Despite the remarkable efficacy of tyrosine kinase inhibitors (TKIs) in eliminating differentiated chronic myeloid leukemia (CML) cells, recent evidence suggests that leukemic stem and progenitor cells (LSPCs) persist long term, which may be partly attributable to cytokine-mediated resistance.	24363400
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Notably, combination of TKI- and CSL362-induced ADCC caused even greater reduction of CML progenitors and further augmented their preferential elimination over normal hematopoietic stem and progenitor cells.	24363400
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSCs) have been defined as 'a cell within a tumor that possesses the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor'.	24366074
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Patients who are newly diagnosed with acute myeloid leukemia and who are 28 days through 18 years old (n = 1,673) hospitalized any time from initial diagnosis through 9 months following diagnosis or until stem cell transplant.	24366507
Toxic effect	Stem Cell Exhaustion	Allogeneic stem-cell transplantation (alloSCT) might improve survival at the expense of increased toxicity.	24366930
Neoplasms	Stem Cell Exhaustion	High-dose caspofungin as a component of combination antifungal therapy in 91 patients with neoplastic diseases and hematopoietic stem cell transplantation: a critical review of short-term and long-term adverse events.	24366977
Graft-vs-Host Disease	Stem Cell Exhaustion	A total of 45 (49%) patients had undergone stem cell transplantation; 80% received allogeneic grafts and 47% had graft-versus-host disease.	24366977
Hyperbilirubinemia, Hematologic Neoplasms	Stem Cell Exhaustion	Drug-induced hyperbilirubinemia may pose a potential limitation for continued HD-CSP use in highly susceptible patients with hematologic neoplasms and stem cell transplantation.	24366977
Aplastic Anemia	Stem Cell Exhaustion	This study was purposed to investigate the safety and effectivity of haploidentical stem cell transplantation for chronic aplastic anemia (CAA) by using two kind of third part cells: umbilical cord derived mesenchymal stem cells (hUC-MSC) and haploidentical umbilical cord blood cells.	24370041
Aplastic Anemia	Stem Cell Exhaustion	[Transplantation of haploidentical-hematopoietic stem cells combined with two kind of third part cells for chronic aplastic anemia: one case report].	24370041
Infection of bloodstream	Stem Cell Exhaustion	Incidence, risk factors, and outcome of bloodstream infections during the pre-engraftment phase in 521 allogeneic hematopoietic stem cell transplantations.	24372809
Behavioral Symptoms Index Composite Score (BASC-2), Infection of bloodstream	Stem Cell Exhaustion	Bloodstream infection (BSI) after allogeneic hematopoietic stem cell transplantation (HSCT) is a well-known complication during the pre-engraftment phase.	24372809
Malignant germ cell neoplasm of mediastinum	Stem Cell Exhaustion	High-dose chemotherapy followed by autologous peripheral blood stem cell transplantation for recurrent primary mediastinal malignant germ cell tumor: a case report.	24373121
Hematological Disease	Stem Cell Exhaustion	Between January 2005 and January 2010, 84 cases of IFDs (39 proven and 45 probable) treated with combo were collected in 20 Hematological Italian Centres, in patients who underwent chemotherapy or allogeneic haematopoietic stem cell transplantation for haematological diseases.	24373120
Graft-vs-Host Disease	Stem Cell Exhaustion	Bone marrow graft-versus-host disease: evaluation of its clinical impact on disrupted hematopoiesis after allogeneic hematopoietic stem cell transplantation.	24374213
Unknown (origin) (qualifier value)	Stem Cell Exhaustion	Idiopathic cytopenias are frequently observed in patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT).	24374213
Primary malignant neoplasm	Stem Cell Exhaustion	Adjuvant high-dose chemotherapy with autologous hematopoietic stem cell support for high-risk primary breast cancer: results from the Italian national registry.	24374214
Childhood Breast Carcinoma	Stem Cell Exhaustion	The efficacy of high-dose chemotherapy (HDC) and autologous hemopoietic progenitor cell transplantation (AHPCT) for breast cancer (BC) patients has been an area of intense controversy among the medical oncology community.	24374214
Neoplasms	Stem Cell Exhaustion	GCC and AMN may share a common tumor stem cell with potential of multiple lineage differentiations.	24374723
Cytomegalovirus Infections	Stem Cell Exhaustion	Effect of the IL28B Rs12979860 C/T polymorphism on the incidence and features of active cytomegalovirus infection in allogeneic stem cell transplant patients.	24374819
Cytomegalovirus Infections	Stem Cell Exhaustion	The current study was aimed at investigating whether the single nucleotide polymorphism (SNP) (rs12979860), upstream of the IL28B gene, had any effect on the incidence rate and the features of active CMV infection in the Allogeneic stem cell transplantation setting.	24374819
Prostate carcinoma	Stem Cell Exhaustion	Validation of stem cell markers in clinical prostate cancer: a6-integrin is predictive for non-aggressive disease.	24375374
Prostate carcinoma	Stem Cell Exhaustion	Various proteins (a2-integrin, a6-integrin, CD117, CD133, EZH2, OCT3/4) are associated with a prostate cancer stem cell phenotype in cell lines and xenografts.	24375374
Prostate carcinoma	Stem Cell Exhaustion	Our objective was to investigate expression of stem cell markers in clinical prostate cancer in relation to outcome.	24375374
Prostate carcinoma	Stem Cell Exhaustion	We validated immunohistochemical expression of stem cell markers in 481 prostate cancer patients and correlated expression with clinicopathologic parameters.	24375374
Prostate carcinoma	Stem Cell Exhaustion	Expression of a2-integrin and EZH2 in a small fraction of prostate cancer cells is supportive for their role as stem cell marker.	24375374
Cessation of life, Prostate carcinoma	Stem Cell Exhaustion	Although a6-integrin was not a unique stem cell marker, it was predictive for prostate cancer biochemical and local recurrence, and disease specific death.	24375374
Prostate carcinoma	Stem Cell Exhaustion	The validity of CD117, CD133, and OCT3/4 as prostate cancer stem cell marker is questionable since these proteins were not expressed in clinical prostate cancer.	24375374
Prostate carcinoma, Neoplasms	Stem Cell Exhaustion	Stem cells are postulated to mediate prostate cancer progression, and represent a small fraction of the entire tumor.	24375374
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic stem cell transplantation as initial salvage for patients with acute myeloid leukemia refractory to high-dose cytarabine-based induction chemotherapy.	24375514
Glioblastoma Multiforme Pathway, Glioma, Neoplasms	Stem Cell Exhaustion	To deepen our comprehension on tumor heterogeneity, we dissected the mechanism of interaction between tumor cells and relevant components of the neoplastic environment, isolating, from LGG and high-grade gliomas (HGG), proliferating stem cell lines from both the glioma stroma and, where possible, the neoplasm.	24375787
Glioma	Stem Cell Exhaustion	Glioma-associated stem cells: a novel class of tumor-supporting cells able to predict prognosis of human low-grade gliomas.	24375787
Intralymphatic Route of Drug Administration, Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	The aim of this study was to clarify the biological properties of intralymphatic tumors susceptible to the development of lymph node metastasis, with special reference to the expression of cancer initiating/stem cell (CIC/CSC) related markers in cancer cells and the number of infiltrating stromal cells.	24376714
Heat-Shock Response, Chlamydia	Stem Cell Exhaustion	GroEL1, a heat shock protein 60 of Chlamydia pneumoniae, impairs neovascularization by decreasing endothelial progenitor cell function.	24376840
Hyperglycemia, Atherosclerosis, Hypertension, CTCAE	Stem Cell Exhaustion	The number and function of endothelial progenitor cells (EPCs) are sensitive to hyperglycemia, hypertension, and smoking in humans, which are also associated with the development of atherosclerosis.	24376840
leukemia	Stem Cell Exhaustion	On the basis of these findings, we propose that ASP represents a potentially important agent for leukemia stem cell-targeted therapy.	24377566
leukemia	Stem Cell Exhaustion	Leukemia stem cells (LSCs) play important roles in leukemia initiation, progression and relapse, and thus represent a critical target for therapeutic intervention.	24377566
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Senescence effects of Angelica sinensis polysaccharides on human acute myelogenous leukemia stem and progenitor cells.	24377566
Growth arrest	Stem Cell Exhaustion	Here, we report that the hESC lines HUES-7 and -9 carrying multiple chromosomal alterations produce in vitro mesenchymal stem cells (MSCs) that show progressive growth arrest and enter senescence after 15 and 16 passages, respectively.	24380659
Impaired cognition, Traumatic, Nerve Degeneration	Stem Cell Exhaustion	Intravenous transplants of human adipose-derived stem cell protect the brain from traumatic brain injury-induced neurodegeneration and motor and cognitive impairments: cell graft biodistribution and soluble factors in young and aged rats.	24381292
Cardiotoxicity	Stem Cell Exhaustion	Assessment and comparison of acute cardiac toxicity during high-dose cyclophosphamide and high-dose etoposide stem cell mobilization regimens with N-terminal pro-B-type natriuretic peptide.	24382557
HD Term Type	Stem Cell Exhaustion	This study was undertaken to prospectively evaluate and compare the acute effect of high-dose (HD), cyclophosphamide (CY) and HD etoposide (ET) on cardiac function assessed by plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients undergoing stem-cell mobilization.	24382557
Cardiotoxicity, HD Term Type	Stem Cell Exhaustion	Our results suggest that stem cell mobilization with HD CY and HD ET cause acute cardiac toxicity mediated by neurohumoral activation, which was detected by the increases in cardiac biomarker NT-proBNP, and as a matter of fact cardiotoxicity of HD ET seems to be more potent than those exhibited by HD CY.	24382557
Parainfluenza virus	Stem Cell Exhaustion	DAS181 treatment of hematopoietic stem cell transplant patients with parainfluenza virus lung disease requiring mechanical ventilation.	24383501
Parainfluenza	Stem Cell Exhaustion	Parainfluenza infection is a cause of significant morbidity and mortality in allogeneic hematopoietic stem cell transplant (HSCT) patients.	24383501
Lymphoma	Stem Cell Exhaustion	When excluding patients who returned for chemotherapy, patients with lymphoma who were male, had undergone hematopoietic stem cell transplantation, and had a creatinine level >= 1.3 mg/dL demonstrated increased risk for return to the primary acute care service.	24384360
Colorectal Carcinoma, Intestinal Cancer	Stem Cell Exhaustion	The recently suggested intestinal cancer stem cell marker DCLK1 is an epigenetic biomarker for colorectal cancer.	24384857
Colorectal Carcinoma, Intestinal Cancer	Stem Cell Exhaustion	Recently, Dclk1 expression was identified to be an intestinal cancer stem cell specific biomarker in mouse models, implicating a potential role for targeting the DCLK1-postive cancer cells as a treatment for colorectal cancer.	24384857
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	This therapy would at best affect the cancer stem cell population, but will, based on the present results, not be efficient to treat the bulk of the tumor.	24384857
Specialty Type - cancer, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Studies on microRNAs that are correlated with the cancer stem cells in chronic myeloid leukemia.	24385111
Specialty Type - cancer, Neoplasms, Secondary Neoplasm, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Accumulating data indicate that cancer stem cells play an important role in tumorigenesis and are underlying cause of tumor recurrence and metastasis, specifically in chronic myeloid leukemia (CML).	24385111
Specialty Type - cancer, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We aim to detect the miRNAs that are correlated with the cancer stem cells in CML to provide theoretical basis for clinical application.	24385111
Amyloidosis	Stem Cell Exhaustion	Induction therapy with bortezomib and dexamethasone followed by autologous stem cell transplantation versus autologous stem cell transplantation alone in the treatment of renal AL amyloidosis: a randomized controlled trial.	24386911
Amyloidosis	Stem Cell Exhaustion	Although the use of bortezomib alone and in combination with steroids has shown efficacy in AL amyloidosis, its role in combination with high-dose melphalan and autologous stem cell transplantation (HDM/SCT) is unknown.	24386911
Thrombocytosis, Polycythemia Vera, Primary Myelofibrosis, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation in patients with polycythemia vera or essential thrombocythemia transformed to myelofibrosis or acute myeloid leukemia: a report from the MPN Subcommittee of the Chronic Malignancies Working Party of the European Group for Blood and Marrow Transplantation.	24389309
Thrombocytosis, Polycythemia Vera	Stem Cell Exhaustion	Allogeneic stem cell transplantation is currently the only potentially curative treatment for advanced polycythemia vera or essential thrombocythemia.	24389309
Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	These results suggest that the GBM-HSF cell line will provide a good model to study the properties of cancer stem cells and metastasis.	24390806
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Immunohistochemical analysis showed that 80.9% of the tumor cells were positive for CD133, a cancer stem cell marker.	24393908
Specialty Type - cancer	Stem Cell Exhaustion	This case illustrates a possible relationship between cancer stem cells and chemoresistance.	24393908
Liver Dysfunction	Stem Cell Exhaustion	Transient liver function abnormality following treatment with rabbit antithymocyte globulin for nonmyeloablative hematopoetic stem cell transplant: two case reports.	24395543
Fanconi Anemia	Stem Cell Exhaustion	Radiologic differences between bone marrow stromal and hematopoietic progenitor cell lines from Fanconi Anemia (Fancd2(-/-)) mice.	24397476
Blast Phase, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myeloid leukemia is a clonal expansion of hematopoietic progenitor cells characterized by exaggerated proliferation of granulocytic lineage, with chronic phase, accelerated phase and blast crisis.	24399014
Allogeneic Hematopoietic Stem Cell Transplantation, Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Post-transplant lymphoproliferative disease after allogeneic hematopoietic stem cell transplantation: a single-center experience.	24399278
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Post-transplant lymphoproliferative disease (PTLD) is a rare and serious complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT) or solid organ transplantation.	24399278
Hematopoietic Stem Cell Mobilization, Lymphoma	Stem Cell Exhaustion	Chemomobilization with high-dose etoposide and G-CSF results in effective and safe stem cell collection in heavily pretreated lymphoma patients: report from a single institution study and review.	24400988
Lymphoma	Stem Cell Exhaustion	The optimal mobilization strategy prior to autologous stem cell transplantation (auto-SCT) for patients with lymphoma is yet to be determined.	24400988
Hematopoietic Stem Cell Mobilization, Lymphoma	Stem Cell Exhaustion	We conclude that HD etoposide and G-CSF chemomobilization appear to result in effective, tolerable, and safe stem cell collection in the majority of heavily pretreated lymphoma patients.	24400988
Alzheimers Disease	Stem Cell Exhaustion	Stem cell derived basal forebrain cholinergic neurons from Alzheimer's disease patients are more susceptible to cell death.	24401693
Up	Stem Cell Exhaustion	Induced pluripotent stem cells (iPSCs) derived from patients with AD as well as from normal controls could be efficiently differentiated into neurons with characteristics of BFCNs.	24401693
Adenoma	Stem Cell Exhaustion	Our results suggest that the pituitary stem cell marker GFRa2 is under-expressed in functioning adenomas and over-expressed in NFAs, specifically gonadotropinomas.	24402129
Specialty Type - cancer	Stem Cell Exhaustion	During EMT, cancer cells acquire stem cell properties.	24402192
Colorectal Carcinoma	Stem Cell Exhaustion	We aimed to demonstrate the clinical significance of EMT and the stem cell phenotype in colorectal cancer.	24402192
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In addition to being a highly specific marker for AML diagnosis (positive predictive value 100%; sensitivity 86.1%; negative predictive value 89.4%), we show that AWT1 hypermethylation also discriminates patients that relapse from those achieving complete remission after hematopoietic stem cell transplantation, with similar efficiency to WT1 expression profiling.	24405639
Hepatocellular, Neoplasms	Stem Cell Exhaustion	Tumor cells express both biliary and hepatocellular markers by immunohistochemistry, and may also express progenitor cell and stem cell markers.	24407728
Liver and Intrahepatic Biliary Tract Carcinoma, Carcinogenic Chlorinated Hydrocarbon, Experimental Organism Malignant Hepatocholangiocellular Carcinoma, Genotype	Stem Cell Exhaustion	Combined hepatocellular-cholangiocarcinoma (CHC), also referred to as primary liver carcinoma (PLC) with biphenotypic differentiation, is an increasingly recognized subtype of malignant PLC encompassing varying morphologic forms thought to arise either from progenitor cell lineage or dedifferentiation of mature liver cells.	24407728
Malignant neoplasm of ovary	Stem Cell Exhaustion	In ovarian cancer, CD44+/CD117+ stem cells, also known as cancer-initiating cells (CICs), are highly proliferative and invasive.	24408020
Toxic effect, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Finally, we demonstrated that TTT-3002 is cytotoxic to leukemic blasts isolated from FLT3/ITD-expressing AML patients, while displaying minimal toxicity to normal hematopoietic stem/progenitor cells from healthy blood and bone marrow donors.	24408321
Diplopia	Stem Cell Exhaustion	There was no limbal stem cell deficiency, symblepharon, or diplopia noted in either group.	24411578
Neurologic Manifestations	Stem Cell Exhaustion	[Efficacy of autologous peripheral blood stem cell transplantation (auto-PBSCT) on the neuropathic manifestations in POEMS syndrome].	24411685
Peripheral Nervous System Diseases	Stem Cell Exhaustion	The efficacy of autologous peripheral blood stem cell transplantation (auto-PBSCT) reported in case series has been mainly based on hematologic criteria and clinical recovery of peripheral neuropathy dysfunctions but has not been specifically evaluated.	24411685
Malignant neoplasm of kidney	Stem Cell Exhaustion	Kidney cancer cells secrete IL-8 to activate Akt and promote migration of mesenchymal stem cells.	24412633
Specialty Type - cancer	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) are multipotent adult stem cells that have the capability of homing to cancer cells.	24412633
Specialty Type - cancer, Secondary Neoplasm, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology	Stem Cell Exhaustion	Cancer stem cells: mediators of tumorigenesis and metastasis in head and neck squamous cell carcinoma.	24415402
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSCs) represent a subpopulation of cells responsible for tumor growth.	24415402
Secondary Neoplasm	Stem Cell Exhaustion	HNSCC stem cells mediate tumorigenesis and regional metastasis in vivo.	24415402
SERPINB3 wt Allele	Stem Cell Exhaustion	We hypothesized that the expression of two putative stem cell markers, ABCG2 and Bmi-1, would correlate with disease severity for non diseased, potentially malignant and OSCC specimens and cell lines derived from an equivalent range of tissues.	24415717
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	[Treatment efficacy of imatinib mesylate versus allogeneic hematopoietic stem cell transplantation for patients with chronic myeloid leukemia in chronic phase].	24417923
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	To compare the treatment efficacy of imatinib mesylate versus allogeneic hematopoietic stem cell transplantation (allo-HSCT) for patients with chronic myeloid leukemia in chronic phase.	24417923
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Impact of in vivo T-cell depletion on outcome of AML patients in first CR given peripheral blood stem cells and reduced-intensity conditioning allo-SCT from a HLA-identical sibling donor: a report from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation.	24419525
Arthralgia, Acute lymphocytic leukemia	Stem Cell Exhaustion	Case 2 describes a 48 year-old man with a history of acute lymphoblastic leukemia status post stem cell transplant who presented with diffuse arthralgias involving bilateral ankles, knees, wrists, and elbows.	24421948
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Difference in mobilization of progenitor cells after myocardial infarction in smoking versus non-smoking patients: insights from the BONAMI trial.	24423369
Multiple Myeloma	Stem Cell Exhaustion	Inflammatory markers and development of symptom burden in patients with multiple myeloma during autologous stem cell transplantation.	24423611
Multiple Myeloma	Stem Cell Exhaustion	In this longitudinal study, we examined inflammatory factors related to the development of high symptom burden during autologous hematopoietic stem cell transplant (AuSCT) for multiple myeloma.	24423611
Cytomegalovirus Infections	Stem Cell Exhaustion	Cytomegalovirus infected all cell types but showed higher tropism for stem cells/radial glial cells.	24423639
Congenital Abnormality, Destruction of tissue	Stem Cell Exhaustion	This suggests that the large spectrum of CMV-induced brain abnormalities is caused not only by tissue destruction but also by the particular vulnerability of stem cells during early brain development.	24423639
Prostatic epithelium, Carcinogenesis	Stem Cell Exhaustion	Bisphenol A promotes human prostate stem-progenitor cell self-renewal and increases in vivo carcinogenesis in human prostate epithelium.	24424067
Chronic active Epstein-Barr virus infection	Stem Cell Exhaustion	If it was the identical EBV clone, it is possible that EBV infected progenitor cells common to both NK cells and T cells, that the progenitor cells then differentiated into NK cells and T cells, a chronic active Epstein-Barr virus infection developed, and neoplastic transformation occurred.	24427365
Usual Severity Pain	Stem Cell Exhaustion	Patients with osteoarthritic changes who received mesenchymal stem cells experienced a significant reduction in pain compared with those who received the control, on the basis of visual analog scale assessments.	24430407
Usual Severity Pain	Stem Cell Exhaustion	There was evidence of meniscus regeneration and improvement in knee pain following treatment with allogeneic human mesenchymal stem cells.	24430407
Acute myocardial infarction	Stem Cell Exhaustion	A randomized, open-label, multicenter trial for the safety and efficacy of adult mesenchymal stem cells after acute myocardial infarction.	24431901
Acute myocardial infarction	Stem Cell Exhaustion	Recent studies suggest that the intracoronary administration of bone marrow (BM)-derived mesenchymal stem cells (MSCs) may improve left ventricular function in patients with acute myocardial infarction (AMI).	24431901
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	We retrospectively examined the outcomes of 56 patients with diffuse large B-cell lymphoma (DLBCL) who underwent autologous stem cell transplant (ASCT) with BEAM/BEAC (carmustine, etoposide, cytarabine, melphalan/cyclophosphamide) or busulfan (Bu)-containing conditioning regimens.	24432893
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	High dose chemotherapy with autologous stem cell transplant for patients with transformed B-cell non-Hodgkin lymphoma in the rituximab era.	24432894
Mantle cell lymphoma, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Phase I/II study of bortezomib-BEAM and autologous hematopoietic stem cell transplantation for relapsed indolent non-Hodgkin lymphoma, transformed, or mantle cell lymphoma.	24434781
Lymphoma, Follicular	Stem Cell Exhaustion	Autologous stem cell transplantation for follicular lymphoma is of most benefit early in the disease course and can result in durable remissions, irrespective of prior rituximab exposure.	24438080
Lymphoma, Follicular	Stem Cell Exhaustion	The role of autologous stem cell transplantation (ASCT) and the optimal timing of such transplants in patients with follicular lymphoma (FL) remains contentious.	24438080
varicella zoster	Stem Cell Exhaustion	Clinical features and risk factors for developing varicella zoster virus dissemination following hematopoietic stem cell transplantation.	24438510
varicella zoster, herpesvirus 3, human	Stem Cell Exhaustion	We retrospectively analyzed 80 instances of varicella zoster virus (VZV) disease in 72 patients who underwent allogeneic hematopoietic stem cell transplantation (HSCT) and examined the clinical differences between localized and disseminated disease.	24438510
Ischemia	Stem Cell Exhaustion	Phase I trial: the use of autologous cultured adipose-derived stroma/stem cells to treat patients with non-revascularizable critical limb ischemia.	24438903
Plasmacytoma - category	Stem Cell Exhaustion	Currently available treatment methods for advanced plasmacytoma include surgery, chemotherapy, radiotherapy, immunomodulatory agents, hematopoietic stem cell transplantation and donor lymphocyte infusion.	24438905
Stable chronic Graft vs Host Disease, Pancreatic Extracts, Chronic graft-versus-host disease	Stem Cell Exhaustion	To determine if patients with chronic graft-versus-host disease (cGVHD) following allogeneic hematopoietic stem cell transplantation (HSCT) develop greater loss of pancreatic tissue than patients without cGVHD.	24441578
Aplastic Anemia	Stem Cell Exhaustion	Evaluation of treatment responses and colony-forming progenitor cells in 50 patients with aplastic anemia after immunosuppressive therapy or hematopoietic stem cell transplantation: a single-center experience.	24442858
CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology	Stem Cell Exhaustion	Together, both IST and stem cell transplantation are reasonable treatment options for patients with AA.	24442858
Hemoglobinuria, CTCAE 3.0, CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology	Stem Cell Exhaustion	No obvious correlations between clinical parameters, including age, karyotype, existence of paroxysmal nocturnal hemoglobinuria clones, pretreatment blood counts, progenitor cell counts, and the response to immunosuppressive therapy (IST), were found.	24442858
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Impaired osteogenic differentiation of mesenchymal stem cells derived from bone marrow of patients with lower-risk myelodysplastic syndromes.	24443267
Hepatotoxicity	Stem Cell Exhaustion	The current landscape of in vitro models used to identify drug- or chemical-induced hepatotoxicity relies heavily on cell culture models consisting of HepG2, induced pluripotent stem cell-derived, or primary hepatocytes.	24444127
Neurotoxicity Syndromes	Stem Cell Exhaustion	After 48 h exposure of H9 human neural stem cells to the neurotoxic fragment Ab25-35, mtDNA copy numbers were not significantly altered.	24448779
Degenerative polyarthritis	Stem Cell Exhaustion	Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial.	24449146
Inflammation, Ischemia	Stem Cell Exhaustion	Vascular progenitor cells (VPCs) are recruited into the peripheral blood (PB) following ischemia and inflammation and correlate with vascular health.	24449173
Ischemic cardiomyopathy	Stem Cell Exhaustion	Transendocardial stem cell injection (TESI) with mesenchymal stem cells improves remodeling in chronic ischemic cardiomyopathy, but the effect of the injection site remains unknown.	24449819
Specialty Type - cancer	Stem Cell Exhaustion	Recently, studies indicated that cancer stem cell plays a key role in cancer development and progression.	24450601
Specialty Type - cancer, Squamous cell carcinoma, Trauma Symptom Checklist for Children Questionnaire	Stem Cell Exhaustion	However, the role of cancer stem cell has not been well elucidated in tongue squamous cell carcinoma (TSCC).	24450601
Trauma Symptom Checklist for Children Questionnaire	Stem Cell Exhaustion	The objective of this study was to investigate the relationships between the expressions of stem cell markers and the prognosis of TSCC.	24450601
Trauma Symptom Checklist for Children Questionnaire	Stem Cell Exhaustion	Taken together, these data suggest that the stem cell markers ALDH1, CD44, OCT4 and SOX2 are closely related in TSCC, and the expression of SOX2 can be used as a prognostic indicator of TSCC.	24450601
Brain Injuries	Stem Cell Exhaustion	As neurogenesis is an endogenous response to brain injury, visible as proliferation (of to this moment silent stem or progenitor cells), its further stimulation can present a treatment strategy in addition to stem cell transfer for cell regeneration therapy.	24450810
Kidney Diseases	Stem Cell Exhaustion	[Sodium-losing nephropathy caused by tacrolimus after allogeneic hematopoietic stem cell transplantation].	24452151
Kidney Diseases	Stem Cell Exhaustion	Although sporadic kidney transplantation cases with sodium-losing nephropathy due to tacrolimus have been reported, no prior cases with this complication after hematopoietic stem cell transplantation (HSCT) have been reported.	24452151
Skin infiltration, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	[Inv(16)-type acute myeloid leukemia with repeated skin infiltration without bone marrow relapse before and after allogeneic hematopoietic stem cell transplantation].	24452154
Tissue damage	Stem Cell Exhaustion	Bone marrow mesenchymal stromal cells to treat tissue damage in allogeneic stem cell transplant recipients: correlation of biological markers with clinical responses.	24452962
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Bone marrow mesenchymal stromal cells (BMSCs) have been used to treat acute graft-versus-host disease (GVHD) and other complications following allogeneic hematopoietic stem cell transplantation (SCT).	24452962
Specialty Type - cancer	Stem Cell Exhaustion	A fourth clone, the less motile, displayed a cancer stem cell EpCAM+ phenotype, was essentially b-catenin negative, and was as expected devoid of hepatocytic differentiation capability, yet the most sensitive to doxorubicin treatment.	24453043
Hematologic Neoplasms	Stem Cell Exhaustion	Hematopoietic stem cell transplantation for hematologic malignancies in older adults: geriatric principles in the transplant clinic.	24453296
methyldopa	Stem Cell Exhaustion	Here, we report the tumorigenic potential of induced pluripotent stem cell (iPSC)-derived retinal pigment epithelium (RPE) for the treatment of wet-type, age-related macular degeneration (AMD).	24454843
Immunocompromised Host, Mycoses	Stem Cell Exhaustion	Allogeneic granulocyte transfusion has evolved into a viable therapeutic option for immunocompromised severely neutropenic leukemic patients and those with hematopoietic stem cell transplant with life-threatening bacterial and fungal infections.	24456072
Hematologic Neoplasms, Tuberculosis	Stem Cell Exhaustion	T-SPOT.TB for detection of tuberculosis infection among hematological malignancy patients and hematopoietic stem cell transplant recipients.	24460312
Hematologic Neoplasms, Pregnancy Complications, Infectious	Stem Cell Exhaustion	The diagnosis of latent Mycobacterium tuberculosis infection (LTBI) is recommended in hematological malignancy patients and before hematopoietic stem cell transplantation (Guidelines for the prevention and management of infectious complications of solid organ transplantation, 2004).	24460312
Hematologic Neoplasms	Stem Cell Exhaustion	Our study suggested that the T-SPOT.TB may be more useful for screening LTBI and active TB in hematological malignancy patients and hematopoietic stem cell transplant recipients than the TST test.	24460312
Neoplasms	Stem Cell Exhaustion	This study aimed to evaluate expression of aldehyde dehydrogenase 1 (ALDH1), a putative stem cell marker, in IBC tumors.	24461456
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Tumors arising from cancer stem cells (CSCs) are associated with drug resistance, tumor recurrence, and poor prognosis.	24461456
Stable chronic Graft vs Host Disease	Stem Cell Exhaustion	To assess how BAFF levels relate to transplantation factors and subsequent development of cGVHD, we prospectively monitored 412 patients in the first year after allogeneic peripheral blood or bone marrow hematopoietic stem cell transplantation (HSCT) and censored data at time of cGVHD onset.	24462743
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Antithymocyte globulin before allogeneic stem cell transplantation for progressive myelodysplastic syndrome: a study from the French Society of Bone Marrow Transplantation and Cellular Therapy.	24462982
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We investigated the impact of rabbit antithymocyte globulins (ATG) on patient outcomes after allogeneic stem cell transplantation (allo-SCT) for progressive myelodysplastic syndrome (MDS).	24462982
Virus Diseases	Stem Cell Exhaustion	BK virus disease after allogeneic stem cell transplantation: a cohort analysis.	24462984
FLT3 Internal Tandem Duplication, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Collectively, approximately 30 % of AML children were proved to carry favorable prognostic genetic abnormalities, whereas approximately 10 % had high FLT3-ITD allelic burden and needed a special treatment plan including allogeneic hematopoietic stem cell transplantation.	24464319
Adult Glioblastoma, Neoplasms	Stem Cell Exhaustion	GBMs are proposed to contain a subpopulation of glioblastoma stem cells (GSCs) that sustain tumor progression and therapeutic resistance and can form tumorspheres in culture.	24464841
Prolymphocytic Leukemia	Stem Cell Exhaustion	Successful allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning for B-cell prolymphocytic leukemia in partial remission.	24470149
Medulloblastoma	Stem Cell Exhaustion	High-dose busulfan-thiotepa with autologous stem cell transplantation followed by posterior fossa irradiation in young children with classical or incompletely resected medulloblastoma.	24470384
Medulloblastoma	Stem Cell Exhaustion	The aim of the study is to evaluate the outcome of young children with high risk localized medulloblastomas (newly diagnosed classical or incompletely resected) treated by high-dose busulfan-thiotepa with autologous stem cell rescue (ASCT) followed by focal radiation therapy (RT).	24470384
Aggressive course	Stem Cell Exhaustion	Unsustained complete response of less than 24 months after autologous stem cell transplantation predicts aggressive myeloma with short survival.	24473998
Multiple Myeloma	Stem Cell Exhaustion	To define the impact of duration of CR posttransplantation on survivals, 71 myeloma patients, who underwent an intended early (a staged approach) or frontline use of bortezomib-based induction, followed by autologous stem cell transplantation (ASCT) were studied.	24473998
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Absence of aberrant myeloid progenitor cells at baseline and/or a decrease in the FCSS during treatment identified Int-2 and high risk MDS patients who are likely to respond to treatment with azacitidine.	24474614
Progeria	Stem Cell Exhaustion	An upregulation in the expression of vanilloid transient potential channels 2 enhances hypotonicity-induced cytosolic Ca2+ rise in human induced pluripotent stem cell model of Hutchinson-Gillford Progeria.	24475260
LMNA wt Allele	Stem Cell Exhaustion	The aim of this present study was to examine the expression and functional role of TRP channels in human induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) from the patients with HGPS.	24475260
Episode of	Stem Cell Exhaustion	Hematopoietic stem cell transplantation could not be done and the evolution was fatal in both cases because of severe infectious episodes.	24476615
Hip Joint	Stem Cell Exhaustion	The overarching aim of this study is to assess the feasibility of using periosteal tissue from the femoral neck of arthritic hip joints, usually discarded in the normal course of hip replacement surgery, as an autologous source of stem cells.	24477075
Rheumatoid Arthritis, Degenerative polyarthritis	Stem Cell Exhaustion	In sum, periosteum tissue that is resected with the femoral neck in replacing the hip represents an unprecedented and, to date, unstudied source of stem cells from OA and RA patients.	24477075
Chylothorax	Stem Cell Exhaustion	Eventually, her chylothorax was controlled by pleurodesis, and she was transferred to another hospital for stem cell transplantation.	24477187
Drug Hypersensitivity Syndrome, United States Indian Health Service	Stem Cell Exhaustion	PCR products of various sizes were amplified in four clinical isolates from drug-induced hypersensitivity syndrome (DIHS) patients and 15 isolates from hematopoietic stem cell transplant (HSCT) recipients with HHV-6B reactivation.	24478470
Candidiasis	Stem Cell Exhaustion	Micafungin has been approved for the prophylaxis of Candida infections in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT).	24479680
Cerebrovascular accident	Stem Cell Exhaustion	Intracerebral implantation of autologous peripheral blood stem cells in stroke patients: a randomized phase II study.	24480430
Cerebral Infarction	Stem Cell Exhaustion	In our previous study, intracerebral implantation of peripheral blood stem cells (PBSCs) improved functional outcome in rats with chronic cerebral infarction.	24480430
Specialty Type - cancer	Stem Cell Exhaustion	Nestin, a class VI intermediate filament, is known to be a cancer stem cell (CSC) marker as well as a neuroepithelial stem cell marker.	24481417
Malignant neoplasm of stomach	Stem Cell Exhaustion	Roles of Wnt/b-catenin signaling in the gastric cancer stem cells proliferation and salinomycin treatment.	24481453
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	The Wnt1 protein, a secreted ligand that activates Wnt signaling pathways, contributes to the self-renewal of cancer stem cells (CSCs) and thus may be a major determinant of tumor progression and chemoresistance.	24481453
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A standardized panel of reagents was used to detect residual disease of aberrant myeloid progenitor cells (RD), identify neutrophils/monocytes with dysregulated immunophenotype (dysregulated neutro/mono) and quantify the appearance of CD34(+) B-progenitor-related cluster (hematogones) simultaneously in post-induction BM of adult AML patients.	24481944
Specialty Type - cancer	Stem Cell Exhaustion	Embryonic stem cells (ESC) and cancer stem cells (CSC) have a capacity for self-renewal and differentiation into multiple cell lineages.	24482053
Seckel syndrome	Stem Cell Exhaustion	Successful outcome of allogeneic stem cell transplantation in Seckel syndrome.	24483323
Compression of umbilical cord, Pfaundler-Hurler Syndrome	Stem Cell Exhaustion	Hematopoietic stem cell transplantation effects on spinal cord compression in Hurler.	24483599
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Reprogramming of COPD lung fibroblasts through formation of induced pluripotent stem cells.	24487392
Hemorrhagic cystitis	Stem Cell Exhaustion	High burden of BK virus-associated hemorrhagic cystitis in patients undergoing allogeneic hematopoietic stem cell transplantation.	24488049
Specialty Type - cancer	Stem Cell Exhaustion	Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/b-catenin signaling.	24491301
Colorectal Carcinoma, Specialty Type - cancer, Cytogenetic Complete Response	Stem Cell Exhaustion	However, little is known about the role these mutations play in cancer stem cells (CSCs) associated with colorectal cancer (CRC) tumorigenesis.	24491301
B-Cell Lymphomas	Stem Cell Exhaustion	High-dose chemotherapy with autologous stem cell transplantation for elderly patients with relapsed/refractory diffuse large B cell lymphoma: a nationwide retrospective study.	24492141
B-Cell Lymphomas, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	The number of elderly patients with diffuse large B cell lymphoma (DLBCL) continues to increase but the data regarding autologous stem cell transplantation (ASCT) for elderly patients are limited.	24492141
Endotoxemia	Stem Cell Exhaustion	Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model.	24496748
Diabetes	Stem Cell Exhaustion	This implies that diabetes may lead to reduced endogenous repair mechanisms through altering the differentiation potential of MPCs and, consequently, disrupting the stem cell niche.	24496952
Diabetes, Osteopenia	Stem Cell Exhaustion	This novel mechanism may account for increased bone marrow adipogenesis, severe bone loss, and reduced vascular stem cells leading to chronic secondary complications of diabetes.	24496952
leukemia	Stem Cell Exhaustion	Finally, we hypothesized that CXCR7 potentiates CXCR4 response and may contribute to the maintenance of leukemia by initiating cell recruitment to bone marrow niches that were once occupied by normal hematopoietic stem cells.	24497931
Hyperglycemia, Specimen Type - Menstrual blood, diabetic	Stem Cell Exhaustion	Transplantation of human menstrual blood progenitor cells improves hyperglycemia by promoting endogenous progenitor differentiation in type 1 diabetic mice.	24499421
Specimen Type - Menstrual blood	Stem Cell Exhaustion	Recently, a unique population of progenitor cells was isolated from human menstrual blood.	24499421
Granuloma	Stem Cell Exhaustion	On 55 meshes explanted from humans, we characterised the cells in the inflammatory infiltrate of the granuloma by immunohistochemistry using 10 cellular markers: CD3+ lymphocytes, CD4+ T helper cells, CD8+ cytotoxic T cells, CD20+ B lymphocytes, CD34+ stem cells, CD45R0+ leucocytes, CD68+ macrophages, Mib1 for proliferation, Vimentin for mesenchymal origin, and Desmin for myocytes.	24500375
Non-Small Cell Lung Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Activated leukocyte cell adhesion molecule (CD166): an "inert" cancer stem cell marker for non-small cell lung cancer?	24501004
Non-Small Cell Lung Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Recently, the activated leukocyte cell adhesion molecule (CD166) was identified as an "inert" cancer stem cell (CSC) marker for non-small cell lung cancer (NSCLC).	24501004
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Primary distal femur T-cell lymphoma after allogeneic haematopoietic stem cell transplantation for chronic myeloid leukaemia: a rare case report and literature review.	24501166
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Post-transplant lymphoproliferative disorders originating from T lymphocytes are a rare complication of allogeneic haematopoietic stem cell transplantation (allo-HSCT) that are not usually associated with Epstein-Barr virus infection.	24501166
Amyloidosis	Stem Cell Exhaustion	Outcomes and treatments of patients with immunoglobulin light chain amyloidosis who progress or relapse postautologous stem cell transplant.	24502602
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Lenalidomide-induced graft-vs.-Leukemia effect in a patient with chronic lymphocytic leukemia who relapsed after allogeneic stem cell transplant.	24502832
Specialty Type - cancer	Stem Cell Exhaustion	Expression of the cancer stem cell markers CD44v6 and ABCG2 in tongue cancer: effect of neoadjuvant chemotherapy on local recurrence.	24504189
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	The purpose of this study was to evaluate the effect of NAC on tumor local recurrence using cancer stem cell marker immunohistochemistry.	24504189
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cell marker (CD44v6 and ABCG2) expression was detected by immunohistochemistry.	24504189
Specialty Type - cancer	Stem Cell Exhaustion	A low expression of miR-200a was also observed in cancer stem cell-enriched spheroid growth conditions (P<0.05).	24504363
Specialty Type - cancer, Cytogenetic Complete Response, MIR200A gene	Stem Cell Exhaustion	MiR-200a has a regulatory effect on EMT and is associated with cancer stem cell properties in CRC.	24504363
Failure (biologic function)	Stem Cell Exhaustion	We made the hypothesis that it would be possible to load these grafts with bone marrow derived mesenchymal stem cells (MSC) to rescue the osteogenic capacity of an allogenic dead bone and therefore enhance incorporation of allografts with the host bone and decrease the number of failures related to the allograft.	24509980
Failure	Stem Cell Exhaustion	The rate of mechanical failure was highest (p = 0.01) among the 30 patients with allograft without stem cells (9/30; 30 %) compared with no failures for patients with allograft loaded with stem cells.	24509980
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	In cancer cells, the process of epithelial-mesenchymal transition (EMT) confers migratory and invasive capacity, resistance to apoptosis, drug resistance, evasion of host immune surveillance and tumor stem cell traits.	24510113
Amyotrophic Lateral Sclerosis	Stem Cell Exhaustion	Intraspinal neural stem cell transplantation in amyotrophic lateral sclerosis: phase 1 trial outcomes.	24510776
Amyotrophic Lateral Sclerosis, Antilymphocyte Serum	Stem Cell Exhaustion	Our overall objective was to assess the safety and feasibility of stem cell transplantation into lumbar and/or cervical spinal cord regions in amyotrophic lateral sclerosis (ALS) subjects.	24510776
Antilymphocyte Serum	Stem Cell Exhaustion	Here, we describe the safety and functional outcome monitoring results for the final trial cohort, consisting of 6 ALS subjects receiving 5 unilateral cervical intraspinal neural stem cell injections.	24510776
Antilymphocyte Serum	Stem Cell Exhaustion	Analyses on outcome data revealed preliminary insight into potential windows of stem cell biological activity and identified clinical assessment measures that closely correlate with ALS Functional Rating Scale-Revised scores, a standard assessment for ALS clinical trials.	24510776
Antilymphocyte Serum	Stem Cell Exhaustion	This is the first report of cervical and dual-targeted intraspinal transplantation of neural stem cells in ALS subjects.	24510776
Specialty Type - cancer	Stem Cell Exhaustion	Aldehyde dehydrogenase-1 (ALDH1) has been considered as a potential cancer stem cell marker in different types of cancer.	24511023
Squamous cell carcinoma of vulva, Specialty Type - cancer	Stem Cell Exhaustion	Contrary to the characteristics of cancer stem cells shown in other types of cancer with positive expression of ALDH1, the positive expression of ALDH1 in patients with vulvar squamous cell carcinoma indicates a significantly better prognosis.	24511023
Electrocardiogram: myocardial infarction (finding), Ventricular Dysfunction	Stem Cell Exhaustion	Results from pre-clinical studies and the CADUCEUS (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction) trial support the notion that cardiosphere-derived cells (CDCs) from normal and recently infarcted hearts are capable of regenerating healthy heart tissue after myocardial infarction (MI).	24511463
Hematologic Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	Ferritin has been shown to be prognostically relevant in breast cancer and in patients with hematologic malignancies undergoing autologous or allogeneic stem cell transplantation.	24512320
Multiple Myeloma	Stem Cell Exhaustion	In the present study, we evaluated the prognostic relevance of pretransplant ferritin levels in 137 patients with myeloma (median age: 56 years) subjected to autologous stem cell transplantation in our institution between 1994 and 2010.	24512320
Malignant neoplasm of breast, Specialty Type - cancer	Stem Cell Exhaustion	If we take translocation frequency as a surrogate marker of potential carcinogenic effect of radiation, the current results suggest that fetal irradiation can induce persistent potential carcinogenic damage in mammary stem/progenitor cells but this does not contribute to the increased risk of cancer since it has been reported that irradiation of fetal rats of the SD strain does not increase the risk of mammary cancers.	24512615
Hypersensitivity	Stem Cell Exhaustion	Moreover, ectopic expression of HACE1 in striatal neuronal progenitor cells provided protection against mutant Huntingtin-induced redox imbalance and hypersensitivity to oxidative stress, by augmenting NRF2 functions.	24516159
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In acute myeloid leukemia (AML), the leukemia initiating cells (LICs) or leukemia stem cells (LSCs) is found within the CD34+CD38- cell compartment.	24517186
Specialty Type - cancer	Stem Cell Exhaustion	The Wnt signaling pathway is a developmental and stem cell pathway that plays an important role in tumorigenesis and may affect cancer progression.	24517998
Childhood Breast Carcinoma, Secondary Neoplasm	Stem Cell Exhaustion	Breast cancer stem cells are thought to be associated with metastasis and poor prognosis, but their clinical importance remains poorly understood.	24519209
Childhood Breast Carcinoma, Secondary Neoplasm	Stem Cell Exhaustion	The aim of this study was to investigate whether certain phenotypes of breast cancer stem cells were clinically important factors regarding metastasis.	24519209
Childhood Breast Carcinoma, Neoplasms	Stem Cell Exhaustion	Breast cancer stem cells were identified by immunohistochemical staining of CD44, CD24, and aldehyde dehydrogenase 1 (ALDH1) in tumor tissues from primary and recurrent or metastatic lesions.	24519209
Childhood Breast Carcinoma	Stem Cell Exhaustion	CD44+/CD24- cells and ALDH1+ cells were considered breast cancer stem cells.	24519209
Childhood Breast Carcinoma, Secondary Neoplasm	Stem Cell Exhaustion	Our findings suggest that ALDH1+ and CD44+/CD24- breast cancer stem cells play significant roles in metastasis.	24519209
Gastrointestinal mucositis	Stem Cell Exhaustion	Efficacy of cryotherapy associated with laser therapy for decreasing severity of melphalan-induced oral mucositis during hematological stem-cell transplantation: a prospective clinical study.	24519448
Hematopoietic Neoplasms, Multiple Myeloma	Stem Cell Exhaustion	Melphalan followed by hematopoietic stem-cell transplantation (HSCT) is the standard treatment for multiple myeloma and other hematopoietic neoplasms.	24519448
Mixed Oligodendroglioma-Astrocytoma, Astrocytoma	Stem Cell Exhaustion	High expression of the stem cell marker nestin is an adverse prognostic factor in WHO grade II-III astrocytomas and oligoastrocytomas.	24519516
Neoplasms	Stem Cell Exhaustion	Pubertal bisphenol A exposure alters murine mammary stem cell function leading to early neoplasia in regenerated glands.	24520039
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	It also reduces the number of radio-resistant CD133(+) glioma stem cells.	24521695
Neoplasms	Stem Cell Exhaustion	Finally, using a stem cell proliferation assay and tumour xenotransplantation assay in non-obese diabetic/severe combined immunodeficiency mice, we show that HAGE promotes MMICs-dependent tumour initiation and tumour growth by preventing the anti-proliferative effects of interferon-a (IFNa).	24525737
melanoma, Specialty Type - cancer	Stem Cell Exhaustion	Here, we show the involvement of the helicase HAGE in the transcriptional repression of PML expression in ABCB5+ malignant melanoma-initiating cells (ABCB5+ MMICs), a population of cancer stem cells which are responsible for melanoma growth, progression and resistance to drug-based therapy.	24525737
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	cIAP1, SMAC, and caspase-8 appear to play a role in AML stem cell survival, and synergistic targeting of these cells with birinapant and demethylating agents shows potential utility in leukemia therapy.	24526787
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Synergistic targeting of AML stem/progenitor cells with IAP antagonist birinapant and demethylating agents.	24526787
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukemia (AML) therapy has limited long-term efficacy because patients frequently develop disease relapse because of the inability of standard chemotherapeutic agents to target AML stem/progenitor cells.	24526787
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Here, we identify deregulated apoptotic components in AML stem/progenitor cells and investigate the individual and combinatorial effects of the novel inhibitor of apoptosis (IAP) protein antagonist and second mitochondrial-derived activator of caspases (SMAC) mimetic birinapant and demethylating epigenetic modulators.	24526787
Cessation of life, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Birinapant induced death receptor-/caspase-8-mediated apoptosis in AML cells, including in AML stem/progenitor cells, but not in normal CD34(+) cells.	24526787
Graft-vs-Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	In unrelated donor allogeneic stem cell transplantation (URD-SCT), most studies reported that peripheral blood stem cells (PBSC) resulted in higher incidence of acute and/or chronic graft-versus-host disease (GVHD) without survival benefits compared with bone marrow (BM).	24527665
Graft-vs-Host Disease, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Similar outcomes of peripheral blood stem cells vs. bone marrow for human leukocyte antigen-matched unrelated donor transplantation in adult patients with acute myeloid leukemia using risk-adapted graft-versus-host disease prophylaxis.	24527665
Specialty Type - cancer, Squamous cell carcinoma of the head and neck	Stem Cell Exhaustion	Spatial distribution of cancer stem cells in head and neck squamous cell carcinomas.	24527751
Specialty Type - cancer	Stem Cell Exhaustion	miR-296-5p is a central regulator of signalling pathways affecting development, stem cell differentiation and cancer.	24527800
Childhood Breast Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	We hypothesized that miR-296-5p is involved in breast cancer onset and progression possibly through regulation of its target SCRIB (Scribble), a polarity protein recently implicated in the acquisition of cancer stem cell traits and in cell motility.	24527800
Malignant Neoplasms	Stem Cell Exhaustion	A prospective study of an alemtuzumab containing reduced-intensity allogeneic stem cell transplant program in patients with poor-risk and advanced lymphoid malignancies.	24528216
Graft-vs-Host Disease	Stem Cell Exhaustion	Reduced-intensity conditioning (RIC) regimens for allogeneic stem cell transplant (allo-SCT) have used alemtuzumab to abrogate the risk of graft-versus-host disease (GVHD).	24528216
Non-alcoholic Fatty Liver Disease	Stem Cell Exhaustion	The non-alcoholic fraction of beer increases stromal cell derived factor 1 and the number of circulating endothelial progenitor cells in high cardiovascular risk subjects: a randomized clinical trial.	24530788
Fracture	Stem Cell Exhaustion	While PTH 1-34 enhances the proliferation and expansion of the periosteal stem cell population and accelerates bone formation and fracture healing, the effects are proportionately reduced in aged mice compared to young mice.	24530870
Fracture	Stem Cell Exhaustion	Altogether the findings show that reduced fracture healing in aging involves decreased proliferation and differentiation of stem cells lining the bone surface.	24530870
Bone injury	Stem Cell Exhaustion	Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment.	24530870
Primary Cutaneous B-Cell Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Myeloablative therapy and autologous stem cell transplantation (ASCT) are underutilized in older patients with B cell non-Hodgkin (B-NHL) lymphoma.	24530971
Specialty Type - cancer, Triple Negative Breast Neoplasms	Stem Cell Exhaustion	The TrkB+ cancer stem cells contribute to post-chemotherapy recurrence of triple-negative breast cancers in an orthotopic mouse model.	24531713
Specialty Type - cancer, Triple-Negative Breast Cancer Finding	Stem Cell Exhaustion	Cancer stem cells (CSCs) are believed to have a crucial role in triple-negative breast cancer (TNBC) recurrence.	24531713
Multiple Myeloma	Stem Cell Exhaustion	Subcutaneous bortezomib incorporated into the bortezomib-thalidomide-dexamethasone regimen as part of front-line therapy in the context of autologous stem cell transplantation for multiple myeloma.	24532044
Malignant tumor of cervix	Stem Cell Exhaustion	Clinical significance of the stem cell gene Oct-4 in cervical cancer.	24532469
Malignant tumor of cervix, Psychobiology	Stem Cell Exhaustion	Our results showed that Oct-4 was highly expressed in cervical cancer stem cells; Oct-4 expression was associated with biological behavior and was an independent prognostic factor in cervical cancer.	24532469
Stable chronic Graft vs Host Disease	Stem Cell Exhaustion	To address this in cGVHD, we studied B-cell receptor (BCR) responsiveness in 48 patients who were >1 year out from allogeneic hematopoietic stem cell transplantation (HSCT).	24532806
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Pretransplantation fluorine-18-deoxyglucose--positron emission tomography scan lacks prognostic value in chemosensitive B cell non-hodgkin lymphoma patients undergoing nonmyeloablative allogeneic stem cell transplantation.	24534109
Acute lymphocytic leukemia	Stem Cell Exhaustion	The effect of peritransplant minimal residual disease in adults with acute lymphoblastic leukemia undergoing allogeneic hematopoietic stem cell transplantation.	24548609
Multiple Endocrine Neoplasia Type 1	Stem Cell Exhaustion	Induced pluripotent stem cells as a model for telomeric abnormalities in ICF type I syndrome.	24549038
Hematopoietic stem cells, Lymphoid neoplasm, Myeloid	Stem Cell Exhaustion	Myeloid and lymphoid neoplasms with abnormalities of the FGFR1 gene are a heterogenous group of rare and aggressive hematopoietic stem cell disorders.	24551307
Neoplasm Metastasis	Stem Cell Exhaustion	Secondary malignancies after allogeneic hematopoietic stem cell transplantation using reduced-intensity conditioning and outpatient conduction.	24552480
Malignant Neoplasms	Stem Cell Exhaustion	Patients given allogeneic hematopoietic stem cell transplants (HSCT) may develop secondary malignant neoplasms (SMN).	24552480
Specialty Type - cancer	Stem Cell Exhaustion	Intriguingly, acquired resistance to metformin appears to trigger a transcriptome reprogramming toward a metastatic stem-like profile, as many genes encoding the components of the degradome (KLK11, CTSF, FREM1, BACE-2, CASP, TMPRSS4, MMP16, HTRA1), cancer cell migration and invasion factors (TP63, WISP2, GAS3, DKK1, BCAR3, PABPC1, MUC1, SPARCL1, SEMA3B, SEMA6A), stem cell markers (DCLK1, FAK), and key pro-metastatic lipases (MAGL and Cpla2) were included in the signature.	24553122
Acute leukemia	Stem Cell Exhaustion	Prognostic index for relapsed acute leukemia after allogeneic stem cell transplant.	24555841
Graft-vs-Host Disease	Stem Cell Exhaustion	Narrowband ultraviolet B phototherapy (NB-UVB) is a therapeutic alternative for haematopoietic stem cell transplantation-related skin graft-versus-host disease (GVHD).	24557710
Hematologic Neoplasms, Diabetes Mellitus	Stem Cell Exhaustion	Risk factors for diabetes mellitus and impaired glucose tolerance following allogeneic hematopoietic stem cell transplantation in pediatric patients with hematological malignancies.	24557711
Dominica, Diabetes Mellitus	Stem Cell Exhaustion	Long-term surviving recipients of allogeneic hematopoietic stem cell transplantation (HSCT) often suffer from diabetes mellitus (DM).	24557711
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Approximately one-third of patients with myelodysplastic syndrome (MDS) receiving allogeneic hematopoietic stem cell transplantation (HSCT) are cured by this treatment.	24558201
Lymphoma, Follicular, Respiratory Tract Infections	Stem Cell Exhaustion	A 50 year old Caucasian gentleman with a history of allogeneic haematopoietic stem cell transplant for transformed follicular lymphoma was admitted to hospital with recurrent respiratory tract infections.	24559411
Acute myelomonocytic leukemia	Stem Cell Exhaustion	Cochlear implantation in a patient with acute myelomonocytic leukemia before allogeneic peripheral blood stem cell transplantation.	24560096
leukemia	Stem Cell Exhaustion	A 50-year-old female leukemia patient was successfully implanted with a Nucleus cochlear implant while in complete remission before peripheral blood stem cell transplantation.	24560096
Mantle cell lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation in mantle cell lymphoma: a report from the SFGM-TC.	24563925
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) is considered as an attractive treatment option for young mantle cell lymphoma (MCL) patients.	24563925
Kidney Failure, Acute	Stem Cell Exhaustion	Clofarabine-associated acute kidney injury in patients undergoing hematopoietic stem cell transplant.	24564572
Toxic nephropathy	Stem Cell Exhaustion	Abstract We examined clofarabine pharmacokinetics and association with renal toxicity in 62 patients participating in a phase I-II study of clofarabine-melphalan-alemtuzumab conditioning for hematopoietic stem cell transplant (HSCT).	24564572
Leukemia, T-Cell	Stem Cell Exhaustion	High level of serum soluble interleukin-2 receptor at transplantation predicts poor outcome of allogeneic stem cell transplantation for adult T cell leukemia.	24565990
TCL4 gene, TRPV6 wt Allele	Stem Cell Exhaustion	The prognosis for adult T cell leukemia/lymphoma (ATL) is very poor, and only allogeneic hematopoietic stem cell transplantation (allo-SCT) has been considered to be a curative treatment for ATL.	24565990
diabetic	Stem Cell Exhaustion	Effect of diabetic osteoblasts on osteogenic differentiation of human umbilical cord mesenchymal stem cells.	24566377
diabetic	Stem Cell Exhaustion	This study was aimed to investigate whether osteoblasts from diabetic patients have a promoting effect on osteogenesis of human umbilical cord mesenchymal stem cells (HUMSCs).	24566377
Thrombotic Microangiopathies	Stem Cell Exhaustion	Risk factors for thrombotic microangiopathy in allogeneic hematopoietic stem cell recipients receiving GVHD prophylaxis with tacrolimus plus MTX or sirolimus.	24566710
Multiple Myeloma	Stem Cell Exhaustion	This paper is motivated by the analysis of a longitudinal study on advanced myeloma patients who received stem cell transplants and T cell infusions after the transplants.	24567438
Carcinoma, Transitional Cell	Stem Cell Exhaustion	Stem cell marker-positive stellate cells and mast cells are reduced in benign-appearing bladder tissue in patients with urothelial carcinoma.	24570393
Malignant neoplasm of urinary bladder, Bladder Neoplasm	Stem Cell Exhaustion	Our aim was therefore to determine identities of stem cell marker-positive cells in bladder cancer tissue and to investigate possible associations between these cells and different forms of bladder neoplasia.	24570393
Neoplasms	Stem Cell Exhaustion	Stem cell marker-positive cells exhibiting possible stem cell characteristics included cells in deeper locations of benign and malignant epithelium, and sub-endothelial cells in patients with or without neoplasia.	24570393
Disease, Malignant Neoplasms, Immunoglobulin deficiency, Congenital absence of spleen, HIV Infections	Stem Cell Exhaustion	ACIP also recommends vaccination for certain persons at increased risk for Hib disease (i.e., persons who have early component complement deficiencies, immunoglobulin deficiency, anatomic or functional asplenia, or HIV infection; recipients of hematopoietic stem cell transplant; and recipients of chemotherapy or radiation therapy for malignant neoplasms).	24572654
Acute myocardial infarction	Stem Cell Exhaustion	An increase of endothelial progenitor cells (EPCs) among acute myocardial infarction (AMI) patients participating in a cardiac rehabilitation (CR) program has been reported, but no data on the impact of adherence to lifestyle recommendations provided during a CR program on EPCs are available.	24573342
Degenerative disorder, methyldopa	Stem Cell Exhaustion	A recent example is the development of stem cell-based therapies for degenerative eye diseases including AMD.	24573369
Degenerative disorder	Stem Cell Exhaustion	The utility of this behavior was described in terms of how it could allow us to remove road blocks in the clinical development pipeline, and more efficiently and economically move stem cell-based therapies for retinal degenerative diseases toward the clinic.	24573369
Hepatitis B	Stem Cell Exhaustion	Hepatitis B reactivation in HBsAg-negative/HBcAb-positive allogeneic haematopoietic stem cell transplant recipients: risk factors and outcome.	24575948
Hepatitis B	Stem Cell Exhaustion	HBsAg-negative/HBcAb-positive haematopoietic stem cell transplant (HSCT) recipients are at high risk of hepatitis B virus (HBV) reactivation.	24575948
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Pulmonary chronic graft-versus-host disease (cGvHD) is one of the most common causes of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (aHSCT).	24577553
Chronic Obstructive Airway Disease, Pulmonary arterial hypertension	Stem Cell Exhaustion	Influence of Rho kinase inhibitor Fasudil on late endothelial progenitor cells in peripheral blood of COPD patients with pulmonary artery hypertension.	24579970
Chronic Obstructive Airway Disease, Lung Diseases, Obstructive, Pulmonary arterial hypertension	Stem Cell Exhaustion	The objective of our work was to investigate the influence of Fasudil, a Rho inhibitor on the number and function of the late endothelial progenitor cells in peripheral blood of chronic obstructive pulmonary diseases (COPD) patients with pulmonary artery hypertension.	24579970
Chronic Obstructive Airway Disease, Pulmonary arterial hypertension	Stem Cell Exhaustion	The Rho-kinase inhibitor Fasudil increased the number and enhanced the function of the late endothelial progenitor cells in peripheral blood of COPD patients with pulmonary artery hypertension.	24579970
Glycogen Storage Disease	Stem Cell Exhaustion	Establishment and directed differentiation of induced pluripotent stem cells from glycogen storage disease type Ib patient.	24581426
Disease	Stem Cell Exhaustion	Induced pluripotent stem cells (iPSCs) hold a great promise for advances in developmental biology, cell-based therapy and modeling of human disease.	24581426
Prostate carcinoma	Stem Cell Exhaustion	An expressed retrogene of the master embryonic stem cell gene POU5F1 is associated with prostate cancer susceptibility.	24581739
Specialty Type - cancer	Stem Cell Exhaustion	Our results suggest that a pathway critical to self-renewal of embryonic stem cells may also have a role in the origin of cancer.	24581739
Multiple Myeloma	Stem Cell Exhaustion	Characteristics of unexpected protein bands in multiple myeloma patients after autologous stem cell transplantation.	24582697
Graft-vs-Host Disease	Stem Cell Exhaustion	Immunologic disparities between minor histocompatibility antigen (mHAg) genes on Y (H-Y) and X (H-X) chromosomes contribute to graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) effects observed in male recipients of a female donor (FtoM) hematopoietic stem cell transplant (HCT).	24582729
B-Cell Lymphomas	Stem Cell Exhaustion	Impact of cytomegalovirus replication and cytomegalovirus serostatus on the outcome of patients with B cell lymphoma after allogeneic stem cell transplantation.	24583412
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Stem Cell Exhaustion	Outcome and prognostic factors in patients with mantle-cell lymphoma relapsing after autologous stem-cell transplantation: a retrospective study of the European Group for Blood and Marrow Transplantation (EBMT).	24585719
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	Autologous stem-cell transplantation (autoSCT) is considered a standard treatment of non-frail patients with mantle cell lymphoma (MCL), but little is known about outcome of MCL patients relapsing after autoSCT.	24585719
Malignant tumor of colon	Stem Cell Exhaustion	Prognostic value of stem cell quantification in stage II colon cancer.	24586330
Stage II Colon Cancer AJCC v8	Stem Cell Exhaustion	Stem Cell quantification defined by CD133 and NANOG expression has no correlation with RFS or OS in this cohort of Stage II colon cancer.	24586330
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSCs) are a subset of tumor cells with capacity to self-renew and generate the diverse cells that make up the tumor.	24586330
bone marrow fibrosis, Primary Myelofibrosis	Stem Cell Exhaustion	Dynamic of bone marrow fibrosis regression predicts survival after allogeneic stem cell transplantation for myelofibrosis.	24589549
bone marrow fibrosis, Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase	Stem Cell Exhaustion	We correlate regression of bone marrow fibrosis (BMF) on day 30 and 100 after dose- reduced allogeneic stem cell transplantation (allo-SCT) in 57 patients with primary or post-essential thrombocythemia/polycythemia vera myelofibrosis with graft function and survival.	24589549
Graft-vs-Host Disease	Stem Cell Exhaustion	Although calcineurin inhibitors (CNIs) with short-term methotrexate (stMTX) constitute standard prophylaxis for graft-versus-host diseases (GVHD) in hematopoietic stem cell transplantations (HSCT), comparative efficacy of cyclosporine A (CsA) and tacrolimus (Tac) still remains unclear.	24590535
GTF2A1L wt Allele, altretamine/cisplatin/cyclophosphamide protocol	Stem Cell Exhaustion	Histological examination and immunohistochemical analysis of proliferating hepatocytes and activated hepatic progenitor cells (HPCs) were performed on the liver tissue of patients with ALF (25), ACLF (70), and CHD (70).	24590583
Specialty Type - cancer	Stem Cell Exhaustion	Circulating hematopoietic stem and progenitor cells are myeloid-biased in cancer patients.	24591638
Neoplasms	Stem Cell Exhaustion	Subpopulations of HNSCC display stem cell features that affect patients' tumor control and survival.	24593279
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Experimental and clinical data suggest that solid cancers contain treatment-resistant cancer stem cells that will impair treatment efficacy.	24593279
Specialty Type - cancer, Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology	Stem Cell Exhaustion	The objective of this study was to investigate if head and neck squamous cell carcinoma (HNSCC) also contain cancer stem cells that can be identified by low 26S proteasome activity and if their presence correlates to clinical outcome.	24593279
Congestive heart failure	Stem Cell Exhaustion	Despite a high potential of endothelial progenitor cells (EPCs) for diagnostic purposes, the EPC role in developing ischemic chronic heart failure (CHF) has not been determined obviously.	24594088
Neoplasms	Stem Cell Exhaustion	Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5), which is identified as a novel intestinal stem cell marker, is overexpressed in various tumours.	24594994
Specialty Type - cancer	Stem Cell Exhaustion	We performed a retrospective analysis of patients with TrIL treated at Peter MacCallum Cancer Centre between 2002 and 2012 who achieved CMR after primary therapy who had >=1 subsequent surveillance PET-CT. Of 55 patients with TrIL, 37 (67 %) received autologous stem cell transplantation as consolidation following chemoimmunotherapy.	24595733
Relapsing course	Stem Cell Exhaustion	[Relapsed primary intraocular lymphoma treated with intravitreal methotrexate and high-dose chemotherapy followed by autologous stem cell rescue].	24598193
Progeria	Stem Cell Exhaustion	Induced pluripotent stem cells reveal functional differences between drugs currently investigated in patients with hutchinson-gilford progeria syndrome.	24598781
Progeria	Stem Cell Exhaustion	This work was based on the assumption that mesodermal stem cells, which are derived from Hutchinson-Gilford progeria syndrome-induced pluripotent stem cells expressing major defects associated with the disease, may be instrumental to revealing such effects.	24598781
Cerebral Infarction	Stem Cell Exhaustion	Mobilization of CD133+ progenitor cells in patients with acute cerebral infarction.	24599235
Graft-vs-Host Disease	Stem Cell Exhaustion	Soluble interleukin-2 receptor level on day 7 as a predictor of graft-versus-host disease after HLA-haploidentical stem cell transplantation using reduced-intensity conditioning.	24599414
Acute GVH disease	Stem Cell Exhaustion	Treatment difficulty with acute GVHD - frequent cause of mortality after allogeneic hematopoietic stem cell transplantation.	24601700
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease (aGvHD) remains a significant cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT).	24601700
Graft-vs-Host Disease	Stem Cell Exhaustion	We proved a higher incidence of developing aGvHD in patients with unrelated donor type, TBI conditioning and cyclosporine (CsA) replacement with mycophenolate mofetil due to CsA nephrotoxicity, while other risk factors such as older patient age, the use of peripheral blood progenitor cells and donor/recipient sex mismatch were without statistical significance.	24601700
Malignant Neoplasms	Stem Cell Exhaustion	Effect of dedifferentiation on time to mutation acquisition in stem cell-driven cancers.	24603301
Carcinogenesis	Stem Cell Exhaustion	Our results suggest that dedifferentiation may play an important role in carcinogenesis, depending on how stem cell homeostasis is maintained.	24603301
Carcinogenesis	Stem Cell Exhaustion	If the stem cell population size is held strictly constant (due to all divisions being asymmetric), we found that dedifferentiation acts like a positive selective force in the stem cell population and thus speeds carcinogenesis.	24603301
Carcinogenesis	Stem Cell Exhaustion	Thus, dedifferentiation may play a crucial role, the common modeling assumption of constant stem cell population size may not be adequate, and further progress in understanding carcinogenesis demands a more detailed mechanistic understanding of stem cell homeostasis.	24603301
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Accumulating evidence suggests that many tumors have a hierarchical organization, with the bulk of the tumor composed of relatively differentiated short-lived progenitor cells that are maintained by a small population of undifferentiated long-lived cancer stem cells.	24603301
Specialty Type - cancer	Stem Cell Exhaustion	It is unclear, however, whether cancer stem cells originate from normal stem cells or from dedifferentiated progenitor cells.	24603301
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	A small population of cancer stem cells named the "side population" (SP) has been demonstrated to be responsible for the persistence of many solid tumors.	24603487
Failure, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	The resistance of leukemic stem cells to targeted therapies, such as tyrosine kinase inhibitors (TKIs), results in therapeutic failure or refractory/relapsed disease in chronic myeloid leukemia (CML).	24603487
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	These results suggested that the expression of ABCG2 and the SP may be regulated by PTEN through the PI3K/Akt pathway, which would be a potentially effective strategy for targeting CML stem cells.	24603487
Primary Myelofibrosis	Stem Cell Exhaustion	Enhanced expression of Stim, Orai, and TRPC transcripts and proteins in endothelial progenitor cells isolated from patients with primary myelofibrosis.	24603752
Primary Myelofibrosis, PMF Regimen	Stem Cell Exhaustion	An increase in the frequency of circulating endothelial colony forming cells (ECFCs), the only subset of endothelial progenitor cells (EPCs) truly belonging to the endothelial phenotype, occurs in patients affected by primary myelofibrosis (PMF).	24603752
Bone Density, Osteoporosis, Senile	Stem Cell Exhaustion	The regressive biological function of human bone marrow-derived mesenchymal stem cells (hBMSCs) is one of the key factors resulting in the decrease of bone mass in senile osteoporosis.	24604278
Acute lymphocytic leukemia	Stem Cell Exhaustion	[Imatinib in combination with allogeneic hematopoietic stem cell transplantation improved the outcome of adult Philadelphia chromosome-positive acute lymphoblastic leukemia].	24606651
B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1, BCR gene	Stem Cell Exhaustion	To investigate the role of imatinib in induction therapy for newly diagnosed adult patients with Philadephia chromosome-positive acute lymphoblastic leukemia (Ph+ALL), as well as the status of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in the treatment of adult Ph+ ALL in imatinib era.	24606651
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	[Outcomes of imatinib and allogeneic hematopoietic stem cell transplantation in the treatment of chronic myeloid leukemia].	24606653
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	To compare the curative effect of imatinib and allogeneic hematopoietic stem cell transplant (allo-HSCT) in the treatment of chronic myeloid leukemia (CML).	24606653
Glycogen Storage Disease	Stem Cell Exhaustion	Biodistribution of adult derived human liver stem cells following intraportal infusion in a 17-year-old patient with glycogenosis type 1A.	24607438
Idiopathic pneumonia syndrome, Tumor necrosis	Stem Cell Exhaustion	Randomized, double-blind, placebo-controlled trial of soluble tumor necrosis factor receptor: enbrel (etanercept) for the treatment of idiopathic pneumonia syndrome after allogeneic stem cell transplantation: blood and marrow transplant clinical trials network protocol.	24607553
Gastrointestinal mucositis	Stem Cell Exhaustion	Pharmacoeconomic analysis of palifermin to prevent mucositis among patients undergoing autologous hematopoietic stem cell transplantation.	24607557
Hematologic Neoplasms, Stomatitis	Stem Cell Exhaustion	Trials have shown benefits of palifermin in reducing the incidence and severity of oral mucositis in patients with hematological malignancies undergoing autologous hematopoietic stem cell transplantation (HSCT) with total body irradiation (TBI)-based conditioning regimens.	24607557
Clostridium difficile colitis, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Clostridium difficile infection in patients with acute myelogenous leukemia and in patients undergoing allogeneic stem cell transplantation: epidemiology and risk factor analysis.	24607558
Central Diabetes Insipidus, Clostridium difficile colitis, Diarrhea, Enterocolitis, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Patients receiving treatment for acute myelogenous leukemia (AML) and recipients of allogeneic stem cell transplantation (aSCT) are at high risk of contracting Clostridium difficile infection (CDI), the most frequently observed nosocomial diarrhea and enterocolitis.	24607558
Illness (finding)	Stem Cell Exhaustion	Cord blood eosinophil/basophil progenitor cells (Eo/B) of high risk infants have been shown to predict respiratory illnesses in infancy.	24607604
Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	Our findings demonstrate that CD44v6 is an important cancer stem cell-like marker associated with CaP proliferation, invasion, adhesion, metastasis, chemo-/radioresistance, and the induction of EMT as well as the activation PI3K/Akt/mTOR and Wnt signaling pathways, suggesting that CD44v6 is a novel therapeutic target to sensitize CaP cells to chemo/radiotherapy.	24615685
Respiratory Distress Syndrome, Newborn	Stem Cell Exhaustion	Intratracheal administration of umbilical cord blood-derived mesenchymal stem cells in a patient with acute respiratory distress syndrome.	24616596
Respiratory Distress Syndrome, Adult, Acute Lung Injury	Stem Cell Exhaustion	Umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) have been introduced as a possible therapy in acute lung injury and acute respiratory distress syndrome (ARDS).	24616596
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	T-cell receptor excision circle levels after allogeneic stem cell transplantation are predictive of relapse in patients with acute myeloid leukemia and myelodysplastic syndrome.	24617310
malignant disease	Stem Cell Exhaustion	In this retrospective study, 209 patients with malignant disease were analyzed for levels of T-cell receptor excision circles (TRECs) for the first 24 months after allogeneic stem cell transplantation.	24617310
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This study shows the potential use of TREC measurement in blood to predict relapse in patients with AML and MDS after allogeneic hematopoietic stem cell transplantation.	24617310
Cytochrome-c Oxidase Deficiency	Stem Cell Exhaustion	We describe the natural history of clinical symptoms and brain imaging in two siblings with ACOX1 deficiency, including the younger sibling's response to allogeneic unrelated donor hematopoietic stem cell transplantation (HSCT).	24619150
Have Been Vomiting, Nausea	Stem Cell Exhaustion	Efficacy of aprepitant in preventing nausea and vomiting due to high-dose melphalan-based conditioning for allogeneic hematopoietic stem cell transplantation.	24619827
Hematologic Neoplasms	Stem Cell Exhaustion	Underlying conditions were hematologic malignancy with or without hematopoietic stem cell transplant (n = 25), lung transplant (n = 3), or receipt of cytotoxic chemotherapy (n = 11).	24621016
Neutropenia, Bacteremia, Gastrointestinal mucositis	Stem Cell Exhaustion	Mucositis not neutropenia determines bacteremia among hematopoietic stem cell transplant recipients.	24621081
Neutropenia, Fever, Pregnancy Complications, Infectious	Stem Cell Exhaustion	In the 1960s, it was reported that infectious complications were the main cause of fever during neutropenia that followed hematopoietic stem cell transplant (HSCT).	24621081
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	In this study, we identified 260 cases of non-Burkitt, diffuse aggressive B-cell lymphomas from SWOG S9704, a phase 3 randomized study of standard immunochemotherapy versus autologous stem cell transplantation.	24625415
Stenotrophomonas maltophilia Measurement	Stem Cell Exhaustion	Stenotrophomonas maltophilia infection during allogeneic hematopoietic stem cell transplantation: a single-center experience.	24628242
Stenotrophomonas maltophilia Measurement, Communicable Diseases	Stem Cell Exhaustion	To examine risk factors for Stenotrophomonas maltophilia (S. maltophilia) infection during allogeneic hematopoietic stem cell transplantation (allo-HSCT), we retrospectively analyzed 259 patients who underwent allo-HSCT.	24628242
Multiple Myeloma	Stem Cell Exhaustion	Magnetic resonance imaging pattern of bone marrow involvement as a new predictive parameter of disease progression in newly diagnosed patients with multiple myeloma eligible for autologous stem cell transplantation.	24628463
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We investigated the prognostic value of the magnetic resonance imaging (MRI) pattern of bone marrow involvement in patients with multiple myeloma (MM) eligible for autologous stem cell transplantation (ASCT).	24628463
Hodgkin Disease	Stem Cell Exhaustion	F-18 FDG-PET predicts outcomes for patients receiving total lymphoid irradiation and autologous blood stem-cell transplantation for relapsed and refractory Hodgkin lymphoma.	24628515
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	Total lymphoid irradiation (TLI) followed by high-dose chemotherapy and autologous haematopoietic stem cell transplant (aHSCT) is an effective strategy for patients with relapsed/refractory classical Hodgkin lymphoma (HL).	24628515
Stomatitis, Multiple Myeloma	Stem Cell Exhaustion	The choice of multiple myeloma induction therapy affects the frequency and severity of oral mucositis after melphalan-based autologous stem cell transplantation.	24629850
Morular Metaplasia of the Endometrium, Gastrointestinal mucositis, Multiple Myeloma	Stem Cell Exhaustion	Mucositis is a common complication of high-dose melphalan (HDM) used before autologous stem cell transplantation (ASCT) for multiple myeloma (MM).	24629850
Idiopathic Pulmonary Fibrosis	Stem Cell Exhaustion	In contrast to progenitors isolated from nonfibrotic lungs, IPF mesenchymal progenitor cells produce daughter cells manifesting the full spectrum of IPF hallmarks, including the ability to form fibrotic lesions in zebrafish embryos and mouse lungs, and a transcriptional profile reflecting these properties.	24631025
Idiopathic Pulmonary Fibrosis	Stem Cell Exhaustion	Morphological analysis of IPF lung tissue revealed that mesenchymal progenitor cells and cells with the characteristics of their progeny comprised the fibrotic reticulum.	24631025
Idiopathic Pulmonary Fibrosis	Stem Cell Exhaustion	These data establish that the lungs of patients with IPF contain pathological mesenchymal progenitor cells that are cells of origin for fibrosis-mediating fibroblasts.	24631025
Specialty Type - cancer, Transitional cell carcinoma of bladder	Stem Cell Exhaustion	Expression and prognostic significance of cancer stem cell markers CD24 and CD44 in urothelial bladder cancer xenografts and patients undergoing radical cystectomy.	24631171
Malignant neoplasm of urinary bladder, Specialty Type - cancer	Stem Cell Exhaustion	To evaluate CD24/CD44/CD47 cancer stem cell marker expressions in bladder cancer (BCa) and provide data on their prognostic significance for clinical outcome in patients undergoing radical cystectomy (RC).	24631171
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cell markers CD24/CD44/CD47 are differentially expressed in cells of urothelial BCa in patients undergoing RC and influence cancer-specific survival of patients.	24631171
Specialty Type - cancer	Stem Cell Exhaustion	We assessed overall and cause-specific mortality and risk factors for late mortality in a nation-wide population-based cohort of 4547 adult cancer patients who survived 2 or more years after receiving an autologous hematopoietic stem cell transplantation (HSCT) in Australia between 1992 and 2005.	24631736
Mycoses	Stem Cell Exhaustion	Incidence and outcome of invasive fungal diseases after allogeneic stem cell transplantation: a prospective study of the Gruppo Italiano Trapianto Midollo Osseo (GITMO).	24631738
Mycoses	Stem Cell Exhaustion	Epidemiologic investigation of invasive fungal diseases (IFDs) in allogeneic hematopoietic stem cell transplantation (allo-HSCT) may be useful to identify subpopulations who might benefit from targeted treatment strategies.	24631738
Myeloma cell	Stem Cell Exhaustion	Lymphocyte subset recovery and outcome after autologous hematopoietic stem cell transplantation for plasma cell myeloma.	24631739
Cholangiolocellular Carcinoma	Stem Cell Exhaustion	Cholangiolocellular carcinoma (CoCC) has distinct pathological characteristics, and CoCC is considered to originate from hepatic progenitor or stem cells.	24633664
Bronchiolitis Obliterans, bottle - unit dose	Stem Cell Exhaustion	Bronchiolitis obliterans (BO) is a devastating complication of allogeneic hematopoietic stem cell transplantation (HSCT).	24634108
Secondary Malignant Neoplasm, Central neuroblastoma	Stem Cell Exhaustion	Secondary malignant neoplasms after high-dose chemotherapy and autologous stem cell rescue for high-risk neuroblastoma.	24634399
Secondary Malignant Neoplasm	Stem Cell Exhaustion	Modern treatment protocols utilizing intense induction followed by myeloablative consolidation chemotherapy with autologous stem cell rescue (ASCR) have improved survival rates, but the long-term sequelae, including development of secondary malignant neoplasms (SMN), are just now surfacing.	24634399
HIV-1 Infection Pathway	Stem Cell Exhaustion	The first cure of HIV-1 infection was achieved through complex, multimodal therapy including myeloablative chemotherapy, total body irradiation, anti-thymocyte globulin, and allogeneic stem cell transplantation with a CCR5 delta32 homozygous donor.	24638072
Vascular Diseases	Stem Cell Exhaustion	A novel potential therapy for vascular diseases: blood-derived stem/progenitor cells specifically activated by dendritic cells.	24638886
Histiocytosis, Langerhans-Cell	Stem Cell Exhaustion	Haploidentical parental hematopoietic stem cell transplantation in pediatric refractory Langerhans cell histiocytosis.	24641492
Arterial Stiffness, Hypertensive (finding)	Stem Cell Exhaustion	Circulating endothelial progenitor cells in hypertensive patients with increased arterial stiffness.	24641802
Hypertension, CTCAE	Stem Cell Exhaustion	The potential association between arterial stiffening and circulating endothelial progenitor cells (EPCs) in patients with essential hypertension was investigated.	24641802
Specialty Type - cancer	Stem Cell Exhaustion	The isoform 1 (ALDH1) has been proved useful for the identification of cancer stem cells.	24643706
Contrast - Induced Nephropathy	Stem Cell Exhaustion	Reduction of circulating endothelial progenitor cell level is associated with contrast-induced nephropathy in patients undergoing percutaneous coronary and peripheral interventions.	24646509
Reduced Number, Chronic Kidney Disease, CTCAE	Stem Cell Exhaustion	Reduced number and impaired function of circulating endothelial progenitor cells (EPCs) in patients with chronic kidney disease have been reported.	24646509
Gastrointestinal mucositis	Stem Cell Exhaustion	Reduced intensity conditioning and oral care measures prevent oral mucositis and reduces days of hospitalization in allogeneic stem cell transplantation recipients.	24647488
Gastrointestinal mucositis, Oman	Stem Cell Exhaustion	Oral mucositis (OM) is a side effect of intensive chemotherapy and radiation and has been reported to affect 75-100% of hematopoietic stem cell transplantation (HSCT) recipients.	24647488
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Multicenter study evaluating the impact of hypomethylating agents as bridging therapy to hematopoietic stem cell transplantation in myelodysplastic syndromes.	24648120
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (alloSCT) is currently the only curative treatment modality for myelodysplastic syndromes (MDS).	24648120
Specialty Type - cancer	Stem Cell Exhaustion	Recently, the cancer stem cell hypothesis has become widely accepted.	24650343
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells are thought to possess the ability to undergo self-renewal and differentiation, similar to normal stem cells.	24650343
Graft-vs-Host Disease, Hematological Disease	Stem Cell Exhaustion	In a multicenter collaboration, we carried out T cell-replete, peripheral blood stem cell (PBSC) transplantations from related, HLA-haploidentical donors with reduced-intensity conditioning (RIC) and post-transplantation cyclophosphamide (Cy) as graft-versus-host disease (GVHD) prophylaxis in 55 patients with high-risk hematologic disorders.	24650678
Hematological Disease	Stem Cell Exhaustion	Peripheral blood hematopoietic stem cells for transplantation of hematological diseases from related, haploidentical donors after reduced-intensity conditioning.	24650678
Amyloidosis	Stem Cell Exhaustion	Induction bortezomib in Al amyloidosis followed by high dose melphalan and autologous stem cell transplantation: a single institution retrospective study.	24650974
Amyloidosis	Stem Cell Exhaustion	High-dose melphalan (HDM) followed by autologous stem cell transplant (ASCT) for light chain amyloidosis (AL) was performed in 31 patients at Oregon Health and Science University between 2005 and 2012.	24650974
Allogeneic Hematopoietic Stem Cell Transplantation, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Outcome of patients with abnl(17p) acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation.	24652988
leukemia, Fred Hutchinson/University of Washington Cancer Consortium, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	To accurately define the outcome after allogeneic hematopoietic stem cell transplantation (HSCT) in patients with abnl(17p) AML, we analyzed the results of patients with this abnormality who received an allogeneic HSCT between January 2000 and December 2010 in 1 of 4 well-defined cohorts (Fred Hutchinson Cancer Research Center, Haemato Oncology Foundation for Adults in the Netherlands, Study Alliance Leukemia, German Cooperative Transplant Study Group).	24652988
Disease, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are stem cell disorders that can progress to acute myeloid leukemia.	24652987
Mantle cell lymphoma	Stem Cell Exhaustion	One hundred sixty untreated, stage II-IV mantle cell lymphoma patients <66 years received rituximab (R)-maxi-CHOP (cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone) alternating with R-high-dose cytarabine (6 cycles total), followed by high-dose BEAM/C (bis-chloroethylnitrosourea, etoposide, cytarabine, and melphalan or cyclophosphamide) and autologous stem cell transplantation from 2005 to 2009.	24652994
Hematologic Neoplasms	Stem Cell Exhaustion	This qualitative study of survivors of allogeneic stem cell transplantation (SCT) for haematological malignancy explored attitudes about late effects of therapy, healthcare issues and information needs.	24654219
Toxic effect	Stem Cell Exhaustion	Feasibility of the fludarabine busulfan 3 days and ATG 2 days reduced toxicity conditioning in 51 allogeneic hematopoietic stem cell transplantation: a single-center experience.	24655805
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We evaluated the impact of detection of minimal residual disease by flow cytometry (FCMRD) and CD3 chimerism in relapse in a cohort of 87 patients with acute myeloid leukemia or myelodysplastic syndrome undergoing stem cell transplantation.	24655806
Osteoporosis	Stem Cell Exhaustion	The gene expression profile of primary osteoporosis GSE35956 was downloaded from the GEO (Gene Expression Omnibus) database and included five MSC (mesenchymal stem cell) specimens of normal osseous tissue and five MSC specimens of osteoporosis.	24656062
Diffuse alveolar hemorrhage	Stem Cell Exhaustion	Recombinant human factor VIIa for alveolar hemorrhage following allogeneic stem cell transplantation.	24657447
Diffuse alveolar hemorrhage	Stem Cell Exhaustion	The mortality rate of alveolar hemorrhage (AH) after allogeneic hematopoietic stem cell transplantation is greater than 60% with supportive care and high-dose steroid therapy.	24657447
Communicable Diseases, Multiple Organ Failure, primary disorders	Stem Cell Exhaustion	In patients with AH following hematopoietic stem cell transplantation, clinical factors (ie, worsening infection, multiple organ failure, or recrudescence of primary disease) may be more important than the benefit of enhanced hemostasis from rFVIIa.	24657447
Febrile Neutropenia	Stem Cell Exhaustion	Evaluation of febrile neutropenia in patients undergoing hematopoietic stem cell transplantation.	24658984
Fever	Stem Cell Exhaustion	The aim of this study was to determine the incidence and causes of fever as a major problem contributing to transplantation related mortality among patients undergoing hematopoietic stem cell transplantation (HSCT) and evaluation of antibiotic use, according to reliable guidelines.We retrospectively reviewed hospital records of 195 adult patients who underwent HSCT between 2009-2011 at hematology-oncology and bone marrow transplantation research center.	24658984
Febrile Neutropenia, Fever, Communicable Diseases	Stem Cell Exhaustion	The hospital stay duration was directly related to the numbers of fever episodes (P<0.0001).The rate of febrile episodes in autologous stem cell transplantation was significantly higher compared to allogeneic type (P<0.05).It is necessary to determine not only the local profile of microbiologic pattern, but also antibiotic sensitivities in febrile neutropenic patients following hematopoietic stem cell transplantation, and reassess response to antibiotic treatment to establish any necessity for modifications to treatment guidelines in order to prevent any fatal complications from infection.	24658984
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells, as a subgroup of tumor cells, resemble critical properties of embryonic stem cells (ESCs) such as self-renewal and maintenance of stemness state.	24659265
Abnormal, Neoplasms	Stem Cell Exhaustion	Sox2, one of the genes that maintains self-renewal of embryonic stem cells and relates to the differentiation potential of these cells, is abnormaly expressed in various human tumors.	24659665
Decreased platelet count	Stem Cell Exhaustion	A period of thrombocytopenia is common after stem cell transplantation (SCT).	24660761
Hodgkin Disease	Stem Cell Exhaustion	Efficacy of just-in-time plerixafor rescue for Hodgkin's lymphoma patients with poor peripheral blood stem cell mobilization.	24660786
Lymphoma, Non-Hodgkin, Multiple Myeloma	Stem Cell Exhaustion	Plerixafor is a Food and Drug Administration-approved agent for improving peripheral blood stem cell (PBSC) mobilization in filgrastim (granulocyte-colony-stimulating factor [G-CSF])-stimulated patients with multiple myeloma and non-Hodgkin's lymphoma.	24660786
Adult Myelodysplastic Syndrome, Acute leukemia	Stem Cell Exhaustion	Donor-derived myelodysplastic syndrome and acute leukaemia after allogeneic haematopoietic stem cell transplantation: incidence, natural history and treatment response.	24661075
Acute Myeloid Leukemia with Myelodysplasia-Related Changes	Stem Cell Exhaustion	Donor-derived myelodysplastic syndrome/acute leukaemia (DD-MDS/AL) is a rare life-threatening complication of allogeneic haematopoietic stem cell (HSC) transplantation.	24661075
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Intensified chemo-immunotherapy with or without stem cell transplantation in newly diagnosed patients with peripheral T-cell lymphoma.	24662801
Clostridium difficile colitis	Stem Cell Exhaustion	Early Clostridium difficile infection during allogeneic hematopoietic stem cell transplantation.	24662889
Clostridium difficile colitis, Central Diabetes Insipidus	Stem Cell Exhaustion	Clostridium difficile infection (CDI) is frequently diagnosed in recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT).	24662889
Multiple Myeloma	Stem Cell Exhaustion	Survival of multiple myeloma patients aged 65-70 years in the era of novel agents and autologous stem cell transplantation.	24662986
Intrinsic Factor Deficiency, Mycoses	Stem Cell Exhaustion	Despite the recent introduction of a new class of anti-Aspergillus agents, no standard regimen for the prevention of invasive fungal disease (IFD) following allogeneic hematopoietic stem cell transplantation has been shown to be superior to fluconazole.	24664791
Neoplasms, Medulloblastoma	Stem Cell Exhaustion	Tandem high-dose chemotherapy and autologous stem cell rescue in children with newly diagnosed high-risk medulloblastoma or supratentorial primitive neuro-ectodermic tumors.	24664937
Supratentorial Embryonal Tumor, Not Otherwise Specified, Medulloblastoma	Stem Cell Exhaustion	To assess the feasibility and effectiveness of high-dose chemotherapy (HDC) with stem cell support followed by conventional craniospinal radiotherapy (RT) as treatment for children older than 5 years of age with newly diagnosed high-risk medulloblastoma (MB) or supratentorial PNET (sPNET).	24664937
Bone marrow hypocellularity	Stem Cell Exhaustion	Androgens are a standard therapeutic option for bone marrow failure in those patients with DC who are unable to undergo haematopoietic stem cell transplantation, but there are no systematic data on its use in those patients.	24666134
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukemia (AML) is a heterogeneous clonal disorder of hemopoietic progenitor cells diagnosed in individuals of any age, but with a median age of 67 years at presentation in adults.	24666762
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Biphasic modulation of cancer stem cell-driven solid tumour dynamics in response to reactivated replicative senescence.	24666838
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	We have developed an agent-based model of solid tumour growth whose input population composition is based on the cancer stem-cell hypothesis.	24666838
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	It is used to show how cancer stem cells can drive tumour progression, while non-stem cancer cells (CCs) interfere with this by impeding cancer stem-cell dynamics.	24666838
Cessation of life, Neoplasms	Stem Cell Exhaustion	Model simulations reveal that reactivation of the replicative senescence programme in CCs initially increases total tumour burden, as attrition from cell death is partially averted, but evolves to provide tumour control in the long-term through increasing constraints on stem-cell compartment kinetics.	24666838
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Reactivation of replicative senescence can prolong CC competition with cancer stem cells, thereby ultimately inhibiting malignant progression regardless of tumour size.	24666838
Chronic Kidney Disease, CTCAE, Old age	Stem Cell Exhaustion	Mesenchymal stem cells from rats with chronic kidney disease exhibit premature senescence and loss of regenerative potential.	24667162
Specialty Type - cancer	Stem Cell Exhaustion	IGF-II/IGF1R signalling blockade inhibits Nanog expression and attenuates cancer stem cell features.	24668028
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells (CSCs) are a promising target for treating cancer, yet how CSC plasticity is maintained in vivo is unclear and is difficult to study in vitro.	24668028
Neoplasms	Stem Cell Exhaustion	Here we establish a sustainable primary culture of Oct3/4(+)/Nanog(+) lung CSCs fed with CD90(+) cancer-associated fibroblasts (CAFs) to further advance our knowledge of preserving stem cells in the tumour microenvironment.	24668028
Chronic Kidney Disease, CTCAE	Stem Cell Exhaustion	Chronic kidney disease after autologous stem cell transplantation: analysis of a single center experience.	24668138
Chronic Kidney Diseases, Chronic Kidney Disease, CTCAE	Stem Cell Exhaustion	Chronic kidney disease (CKD) after allogeneic hematopoietic stem cell transplantation (HSCT) has increasingly been reported.	24668138
Pilomatrixoma, Neoplasms	Stem Cell Exhaustion	We aimed at studying cortical differentiation, beta-catenin pathway and expression of the follicular stem-cell marker PHLDA1 in a series of matrical tumors other than pilomatricoma.	24673383
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Intensive chemotherapy and reduced-intensity allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia in elderly patients.	24673966
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This retrospective study assessed the outcomes of older patients with AML treated with intensive chemotherapy with or without allogeneic hematopoietic stem cell transplantation (HSCT).	24673966
Acute GVH disease, Histocompatibility Antigens Class I	Stem Cell Exhaustion	[A comparison of clinical characteristics and prognosis of adult acute graft-versus-host disease between human leukocyte antigen- identical and -mismatched allogeneic hematopoietic stem cell transplantation].	24674726
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	To compare the clinical characteristics and prognosis of acute graft-versus-host disease (aGVHD) between patients undergoing human leukocyte antigen (HLA)-identical and HLA-mismatched allogeneic hematopoietic stem cell transplantation (allo-HSCT).	24674726
Childhood Breast Carcinoma	Stem Cell Exhaustion	This may be related to an insufficient targeting of the CD44(high)CD24(low) breast cancer stem cell subset, which is not only highly resistant to chemotherapy and radiotherapy but also a poor target for trastuzumab due to low HER2 surface expression.	24675467
Childhood Breast Carcinoma	Stem Cell Exhaustion	This revealed that CD44(high)CD24(low)HER2(low) stem cell-like breast cancer cells show high endocytic activity and are thus particularly sensitive towards the antibody-drug conjugate T-DM1.	24675467
Neoplasms	Stem Cell Exhaustion	Moreover, when tumor cells were cocultured with natural killer cells, antibody-dependent cell-mediated cytotoxicity was enhanced, and EMT-mediated induction of stem cell-like properties was prevented in differentiated tumor cells.	24675467
Childhood Breast Carcinoma	Stem Cell Exhaustion	Thus our study reveals an unanticipated targeting of stem cell-like breast cancer cells by T-DM1 that may contribute to the clinical efficacy of this recently approved antibody-drug conjugate.	24675467
Childhood Breast Carcinoma	Stem Cell Exhaustion	Targeting of preexisting and induced breast cancer stem cells with trastuzumab and trastuzumab emtansine (T-DM1).	24675467
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Consequently, preexisting CD44(high)CD24(low) cancer stem cells were depleted by concentrations of T-DM1 that did not affect the bulk of the tumor cells.	24675467
Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	Chemokines are involved in both the negative and positive regulation of inflammatory processes, angiogenesis and cancer/cancer stem cell proliferation as well as the chemoattraction of tumor cells to metastatic sites.	24676787
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	In this study we aimed to isolate stem-like cells from freshly resected LCa tumor specimens and characterize them by quantitative real time PCR (qRT-PCR) for expression of cancer stem cell markers including SOX2, OCT4, KLF4, ABCG2, CXCR4 and CD44.	24678693
Fusariosis, Aplastic Anemia	Stem Cell Exhaustion	Fatal Fusarium solani infection after stem cell transplant for aplastic anemia.	24679137
Aplastic Anemia	Stem Cell Exhaustion	A 21-year-old man with aplastic anemia was treated with an allogeneic stem cell transplant.	24679137
Nonunion of Bone	Stem Cell Exhaustion	Treatment of humeral shaft aseptic nonunions in elderly patients with opposite structural allograft, BMP-7, and mesenchymal stem cells.	24679209
Nonunion of Bone	Stem Cell Exhaustion	This study reports the authors' experience using opposite cortical allograft combined with bone morphogenetic protein 7 and mesenchymal stem cells to treat humeral shaft atrophic nonunions in 2 elderly patients.	24679209
Non-Malignant	Stem Cell Exhaustion	The use of a locking plate and opposite cortical allograft, combined with BMP-7 and mesenchymal stem cells, represents a safe and effective treatment for malignant nonunions in older patients.	24679209
Specialty Type - cancer	Stem Cell Exhaustion	Furthermore, miR-203 may regulate the expressions of mesenchymal transition (EMT) marker of E-cadherin and cancer stem cells (CSCs) marker of CD44.	24682952
Aggressive Non-Hodgkin Lymphoma, Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	Mantle cell lymphoma (MCL) is an aggressive B cell lymphoma, where survival has been remarkably improved by use of protocols including high dose cytarabine, rituximab and autologous stem cell transplantation, such as the Nordic MCL2/3 protocols.	24684350
Lymphoproliferative Disorders	Stem Cell Exhaustion	Comparative analysis of post-transplant lymphoproliferative disorder after kidney transplantation versus hematopoietic stem cell transplantation.	24684689
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	This single center retrospective study enrolled 41 adult PTLD patients after kidney-transplantation (KT, n = 28) and hematopoietic stem cell transplantation (HSCT, n = 13) from 1992 to 2012.	24684689
Depression, CTCAE, Acute Coronary Syndrome	Stem Cell Exhaustion	Impact of depression on circulating endothelial progenitor cells in patients with acute coronary syndromes: a pilot study.	24685963
GDC AJCC Clinical Stage Terminology	Stem Cell Exhaustion	The number of endothelial progenitor cells (EPCs) is an independent predictor of clinical outcomes in patients with ACS.	24685963
Hematopoietic stem cells	Stem Cell Exhaustion	Controlled-rate freezing and storage in vapour phase nitrogen are used by most transplantation teams for the cryopreservation and storage of peripheral blood haematopoietic stem cells (PBSC).	24686987
Hemorrhagic cystitis	Stem Cell Exhaustion	The objective of the study was to study the characteristics of patients suffering hemorrhagic cystitis after hematopoietic stem cell transplantation in our center.	24691038
Specialty Type - cancer	Stem Cell Exhaustion	microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells.	24691539
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells (CSCs) may be one of the causes of therapeutic resistance, but the molecular mechanism underlying this resistance is unclear.	24691539
Specialty Type - cancer, Medulloblastoma	Stem Cell Exhaustion	SHH, WNT, and NOTCH pathways in medulloblastoma: when cancer stem cells maintain self-renewal and differentiation properties.	24695855
Medulloblastoma, Neoplasms, Neuroepithelial	Stem Cell Exhaustion	Infant medulloblastoma (MB) is a malignant neuroepithelial embryonal tumor of the cerebellum, believed to derive from precursor granule cells with stem or progenitor cells appearance, and caused by a change in expression profile of genes related to the development.	24695855
Specialty Type - cancer	Stem Cell Exhaustion	Increasing evidence supports the important role of cancer stem cells (CSCs).	24696843
Liver carcinoma, Specialty Type - cancer, Hollings Cancer Center	Stem Cell Exhaustion	Many reports suggest that epithelial cell adhesion molecule (EpCAM) is a useful marker for cancer stem cells in hepatocellular carcinoma (HCC).	24696843
Specialty Type - cancer	Stem Cell Exhaustion	To elucidate the mechanisms of cancer stem cells, the development of specific molecular targeted drugs has become very important.	24696843
Specialty Type - cancer, Hepatitis B	Stem Cell Exhaustion	Collectively, our results suggest that cancer stem cells are highly expressed in hepatitis B and have potential anticancer drug resistance.	24696843
Dermis, Myeloid Stem Cell, Acute leukemia	Stem Cell Exhaustion	We report a case of a 45-year-old man who developed extramedullary acute leukemia with a myeloid immunophenotype (myeloid sarcoma) with its initial presentation within an isolated pre-existing osteoma cutis in the post-auricular scalp without evidence of systemic acute leukemia or chronic myeloid stem cell disorders.	24698478
End Stage Liver Disease	Stem Cell Exhaustion	Clinical outcome of autologous hematopoietic stem cell infusion via hepatic artery or portal vein in patients with end-stage liver diseases.	24698673
Hepatobiliary Disorder	Stem Cell Exhaustion	To investigate the efficacy of hematopoietic stem cell (HSC) transplantation via the hepatic artery vs. the portal vein for end-stage liver disease (ESLD).	24698673
Italy, Multiple Myeloma	Stem Cell Exhaustion	We analyzed the main modalities and clinical outcomes of the early discharge outpatient model in autologous stem cell transplantation (EDOM-ASCT) for multiple myeloma in Italy.	24699116
Carcinoma	Stem Cell Exhaustion	The re-expression of pluripotent markers (Oct-4 and Nanog) and the reactivation of stem cell-related pathways in oral carcinoma have been well researched.	24700702
Specialty Type - cancer	Stem Cell Exhaustion	However, the relationship between the stem cell signaling molecule b-catenin and pluripotent markers Oct-4 and Nanog in oral cancer is yet to be studied in detail.	24700702
Cerebral Infarction, Decreased platelet count	Stem Cell Exhaustion	Acute cerebral infarct with elevated factor VIII level during the thrombocytopenic stage after hematopoietic stem cell transplant.	24702151
Thromboembolism	Stem Cell Exhaustion	Thromboembolism is a complication of hematopoietic stem cell transplant.	24702151
Cerebral Infarction, Decreased platelet count	Stem Cell Exhaustion	However, a literature search showed no previous reports of cerebral infarction during the thrombocytopenic stage after hematopoietic stem cell transplant.	24702151
Acute lymphocytic leukemia	Stem Cell Exhaustion	A 35-year-old woman with acute lymphoblastic leukemia (precursor B-cell type) was treated with hematopoietic stem cell transplant after induction and consolidation chemotherapy.	24702151
Thromboembolism	Stem Cell Exhaustion	This case suggests that prudent treatment of patients who have hematopoietic stem cell transplant may include monitoring for thromboembolism and testing factor VIII level before transplant.	24702151
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Prognostic impact of minimal residual disease analysis by flow cytometry in patients with acute myeloid leukemia before and after allogeneic hemopoietic stem cell transplantation.	24702162
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic stem cell transplantation (allo-SCT) has become the treatment of choice in patients with intermediate-risk and high-risk acute myeloid leukemia (AML).	24702162
Liver carcinoma, Liver Cirrhosis, Hepatocellular Small Cell Change	Stem Cell Exhaustion	Investigation of diagnostic utility and expression profiles of stem cell markers (CD133 and CD90) in hepatocellular carcinoma, small cell dysplasia, and cirrhosis.	24702884
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	N-Cadherin and Tie2 positive CD34+CD38-CD123+ leukemic stem cell populations can develop acute myeloid leukemia more effectively in NOD/SCID mice.	24703771
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Emerging studies suggest that the population of malignant cells found in human acute myelogenous leukemia (AML) arises from a rare population of leukemic stem cells (LSCs).	24703771
Stable chronic Graft vs Host Disease, Immune-mediated, Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic graft-versus-host disease (cGVHD) is an immune-mediated disorder and is the major long-term complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT).	24704387
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit.	24704494
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Here, we show that patient-derived mesenchymal stromal cells (MDS MSCs) display a disturbed differentiation program and are essential for the propagation of MDS-initiating Lin(-)CD34(+)CD38(-) stem cells in orthotopic xenografts.	24704494
Hematopoietic stem cells, MYELODYSPLASTIC SYNDROME, Myeloid neoplasm	Stem Cell Exhaustion	Myelodysplastic syndromes (MDSs) are a heterogeneous group of myeloid neoplasms with defects in hematopoietic stem and progenitor cells (HSPCs) and possibly the HSPC niche.	24704494
Infectious Lung Disorder	Stem Cell Exhaustion	The predictive value for pulmonary infection by area over the neutrophil curve (D-index) in patients who underwent reduced intensity hematopoietic stem cell transplantation.	24705712
Infectious Lung Disorder	Stem Cell Exhaustion	We evaluated the predictive value of the D-index for pulmonary infection in the early phase of reduced intensity stem cell transplantation (RIST).	24705712
Sepsis	Stem Cell Exhaustion	Endothelial progenitor cells and a stromal cell-derived factor-1a analogue synergistically improve survival in sepsis.	24707934
Sepsis	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) have been associated with human sepsis but their role is incompletely understood.	24707934
Respiratory Distress Syndrome, Newborn	Stem Cell Exhaustion	Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study.	24708472
Lung Injury	Stem Cell Exhaustion	Recent studies have demonstrated that mesenchymal stem cells (MSCs) modulate the immune response and reduce lung injury in animal models.	24708472
Graft-vs-Host Disease, Acute on chronic graft-versus-host disease	Stem Cell Exhaustion	Both acute and chronic graft-versus-host disease (GVHD) are major causes of morbidity and mortality in patients undergoing allogeneic hematopoietic stem cell transplantation (AHSCT).	24709007
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In patients with AML, the use of G-CSF after auto-SCT is not associated with increased risk of relapse irrespective of the source of stem cells used.	24710564
Necrosis	Stem Cell Exhaustion	[Stem cell implant with neck-head decompression for aseptic necrosis of the femoral head].	24712191
Necrosis	Stem Cell Exhaustion	An observational, descriptive, prospective, case-series type of study was conducted to prove the hypothesis that the boring decompression of the femoral neck-head cancellous layer, together with the local implantation of multipotent adult autologous stem cells processed according to Ficoll at approximate amounts of 16.1 x 10(6) cells/ml, is the treatment of choice for stages I-II-III of aseptic necrosis of the femoral head.	24712191
Experimental Organism Malignant Hepatocholangiocellular Carcinoma	Stem Cell Exhaustion	Clinicopathological significance of 'subtypes with stem-cell feature' in combined hepatocellular-cholangiocarcinoma.	24712771
Hollings Cancer Center	Stem Cell Exhaustion	According to the WHO classification 2010, we surveyed the prevalence and clinicopathological significance of each subtype with stem-cell features [SC subtype; typical subtype (TS), intermediate cell subtype (INT) and cholangiolocellular type (CLC)] in cHC-CC and HCC.	24712771
Hollings Cancer Center, Experimental Organism Malignant Hepatocholangiocellular Carcinoma, Malignant neoplasm of liver, Liver carcinoma, Cholangiocarcinoma	Stem Cell Exhaustion	Combined hepatocellular-cholangiocarcinoma (cHC-CC), a malignant liver tumour with poor prognosis, is composed of hepatocellular carcinoma (HCC), cholangiocarcinoma (CC) and diverse components with intermediate features between HCC and CC, which correspond to hepatic progenitor cells.	24712771
Concomitant Medication Submission Domain, Tumor necrosis, diabetic	Stem Cell Exhaustion	In CM derived from CD34+ cells of diabetic individuals (diabetic-CM), the levels of stem cell factor, hepatocyte growth factor, and thrombopoietin were lower, and IL-1b and tumor necrosis factor (TNFa) levels were higher than CM derived from nondiabetic individuals (nondiabetic-CM).	24713821
Diabetes, Hypoxia, Specific antibody deficiency	Stem Cell Exhaustion	We hypothesized that endothelial progenitor cells derived from individuals with diabetes would exhibit functional defects including inability to respond to hypoxia and altered paracrine/autocrine function that would impair the angiogenic potential of these cells.	24713821
diabetic	Stem Cell Exhaustion	Circulating mononuclear cells isolated from diabetic (n = 69) and nondiabetic (n = 46) individuals were used to grow endothelial colony forming cells (ECFC), early endothelial progenitor cells (eEPCs) and isolate CD34+ cells.	24713821
Hypoxia	Stem Cell Exhaustion	Enhanced expression of transcription factor hypoxia inducible factor HIF-1a is known to play a critical role in the modulation of cell metabolism and survival pathways as well as having stem-cell-like properties.	24715760
Hypoxia, Pterygium	Stem Cell Exhaustion	Pterygium, a stem cell disorder with premalignant features, has been reported to demonstrate hypoxia.	24715760
Sarcoma - category (morphologic abnormality)	Stem Cell Exhaustion	In vitro biosafety profile evaluation of multipotent mesenchymal stem cells derived from the bone marrow of sarcoma patients.	24716831
Graft-vs-Host Disease	Stem Cell Exhaustion	In the context of hematopoietic stem cell transplantation (HSCT), mesenchymal stem cells (MSC) have been used to promote engraftment and prevent graft-versus-host disease.	24717223
Usual Severity Pain	Stem Cell Exhaustion	The patient received chemotherapy, which alleviated his limb pain, and achieved stringent complete remission after autologous peripheral blood stem cell transplantation.	24717597
Glioblastoma Multiforme Pathway, Glioma, Specialty Type - cancer	Stem Cell Exhaustion	The objective of this study is to investigate the expression level of periostin in cancer stem cells as well as in the glioma tissues and the relationship between periostin expression and clinical and pathological characteristics and prognosis of gliomas.	24719188
Rheumatoid Arthritis, Degenerative polyarthritis	Stem Cell Exhaustion	Osteoblastic potential of infrapatellar fat pad-derived mesenchymal stem cells from rheumatoid arthritis and osteoarthritis patients.	24720504
Rheumatoid Arthritis, Degenerative polyarthritis, Tumor necrosis	Stem Cell Exhaustion	To evaluate the osteoblastic potential of adipose-derived mesenchymal stem cells (ASCs) from infrapatellar fat pad (IPFP) of rheumatoid arthritis (RA) patients in comparison to osteoarthritis (OA) patients, as well as the influence of tumor necrosis factor alpha (TNFa) on osteoblastic ASC differentiation in vitro.	24720504
Multiple Myeloma	Stem Cell Exhaustion	The osteoblastogenesis potential of adipose mesenchymal stem cells in myeloma patients who had received intensive therapy.	24722177
Multiple Myeloma	Stem Cell Exhaustion	OBs are derived from mesenchymal stem cells (MSCs) from the bone marrow (BM), however the pool and function of BMMSCs in MM patients (MM-BMMSCs) are reduced by myeloma cells (MCs) and cytokines secreted from MCs and related anti-MM treatment.	24722177
Congenital dyserythropoietic anemia, type II	Stem Cell Exhaustion	Successful hematopoietic stem cell transplantation in a patient with congenital dyserythropoietic anemia type II.	24724984
Peripheral Stem Cell Transplantation, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Early lymphocyte recovery at 28 d post-transplant is predictive of reduced risk of relapse in patients with acute myeloid leukemia transplanted with peripheral blood stem cell grafts.	24725056
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We evaluated the impact of lymphocyte recovery at 28 d post-HCT in 191 AML patients using peripheral blood stem cells as graft.	24725056
Hematopoietic stem cells, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We report an unusual case of a 34-year-old patient with acute myeloid leukaemia, status post-allogenic hematopoietic stem cell transplantation who subsequently developed GvHD with skin involvement.	24725497
Immune System Diseases	Stem Cell Exhaustion	Patients who undergo allogeneic stem cell transplantation frequently develop an immunologic disease caused by the reactivation of the graft to the host tissues.	24727333
Hematologic Neoplasms	Stem Cell Exhaustion	Comparable long-term outcome of unrelated cord blood transplantation with related bone marrow or peripheral blood stem cell transplantation in patients aged 45 years or older with hematologic malignancies after myeloablative conditioning.	24727335
Hematologic Neoplasms	Stem Cell Exhaustion	Clinical outcomes of 97 patients aged 45 years or older with hematologic malignancies who received unrelated cord blood transplantation (CBT) (n = 66) or bone marrow transplantation (BMT) or peripheral blood stem cell transplantation (PBSCT) from related donors (n = 31) were compared.	24727335
Malignant neoplasm of ovary, Specialty Type - cancer	Stem Cell Exhaustion	DDX4 (DEAD box polypeptide 4) colocalizes with cancer stem cell marker CD133 in ovarian cancers.	24727449
Malignant neoplasm of ovary, Specialty Type - cancer	Stem Cell Exhaustion	We investigated the relationship between DDX4 and ovarian cancer stem cells by analyzing the expression patterns of DDX4 and the cancer stem cell marker CD133 in ovarian cancers via tissue microarray.	24727449
Malignant neoplasm of ovary, Specialty Type - cancer	Stem Cell Exhaustion	Furthermore, almost all CD133 positive ovarian cancer cells also express DDX4 whereas CD133-negative cells did not possess DDX4, suggesting a strong possibility that DDX4 plays an important role in cancer stem cells, and/or can be used as an ovarian cancer stem cell marker.	24727449
Hematopoietic stem cells, Unknown (origin) (qualifier value), Bone marrow hypocellularity, Aplastic Anemia	Stem Cell Exhaustion	The majority of cases of aplastic anemia remain idiopathic, although hematopoietic stem cell deficiency and impaired immune responses are hallmarks underlying the bone marrow failure in this condition.	24727813
Aplastic Anemia	Stem Cell Exhaustion	We found that mesenchymal stem cell cultures can be established from the bone marrow of aplastic anemia patients and display the same phenotype and differentiation potential as their counterparts from normal bone marrow.	24727813
Aplastic Anemia	Stem Cell Exhaustion	Bone marrow mesenchymal stem cells from patients with aplastic anemia maintain functional and immune properties and do not contribute to the pathogenesis of the disease.	24727813
Aplastic Anemia	Stem Cell Exhaustion	We investigated whether bone marrow mesenchymal stem cells contribute, directly or indirectly, to the pathogenesis of aplastic anemia.	24727813
Aplastic Anemia	Stem Cell Exhaustion	Mesenchymal stem cells from aplastic anemia patients support the in vitro homeostasis and the in vivo repopulating function of CD34(+) cells, and maintain their immunosuppressive and anti-inflammatory properties.	24727813
Aplastic Anemia	Stem Cell Exhaustion	These data demonstrate that bone marrow mesenchymal stem cells from patients with aplastic anemia do not have impaired functional and immunological properties, suggesting that they do not contribute to the pathogenesis of the disease.	24727813
Multiple Myeloma	Stem Cell Exhaustion	Early response-based intensification of primary therapy in newly diagnosed multiple myeloma patients who are eligible for autologous stem cell transplantation: phase II study.	24728664
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	This phase II study prospectively evaluated the efficacy and tolerability of an early change in induction therapy before autologous stem cell transplantation (ASCT) in multiple myeloma (MM) patients who failed to achieve more than a partial response (PR) after two cycles of a cyclophosphamide, thalidomide, and dexamethasone (CTD) regimen.	24728664
Respiratory Tract Infections	Stem Cell Exhaustion	Viral respiratory infections diagnosed by multiplex PCR after allogeneic hematopoietic stem cell transplantation: long-term incidence and outcome.	24732781
Respiratory Tract Infections	Stem Cell Exhaustion	Viral respiratory infections (VRIs) are frequent after hematopoietic stem cell transplantation and constitute a potential cause of mortality.	24732781
Harvesting of peripheral blood stem cells, Pulmonary Embolism, Deep Vein Thrombosis, Heparin-induced thrombocytopenia, Amyloid nephropathy, Upper Extremity Deep Vein Thrombosis	Stem Cell Exhaustion	A 63-year-old Caucasian man with renal amyloidosis undergoing peripheral blood stem cell collection for an autologous stem cell transplant developed extensive bilateral upper-extremity deep venous thrombosis (DVT) and pulmonary embolism secondary to heparin-induced thrombocytopenia.	24733133
Multiple Myeloma	Stem Cell Exhaustion	Patients with multiple myeloma who had undergone a haematopoietic stem cell transplantation and subsequent treatment for at least one episode of progressive disease but were in stable plateau phase were included in the study.	24733635
Vascular Diseases	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) are implicated in protection against vascular disease.	24736282
Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	However, recent studies have challenged the relative importance of these canonical cellular responses for p53-mediated tumour suppression and have highlighted roles for p53 in modulating other cellular processes, including metabolism, stem cell maintenance, invasion and metastasis, as well as communication within the tumour microenvironment.	24739573
CLU protein, human, Ischemia	Stem Cell Exhaustion	We tested the hypothesis that clopidogrel and cilostazol combination therapy could effectively attenuate systemic inflammatory reaction, facilitate proliferation of circulating endothelial progenitor cell (EPC), and improve the clinical outcomes of critical limb ischemia (CLI) in patients unsuitable for surgical revascularization or percutaneous transluminal angioplasty (PTA).	24742198
Ulcer	Stem Cell Exhaustion	As compared with the baseline, circulating endothelial progenitor cell level (as shown by flow cytometry) was significantly increased (p<0.003), whereas the CLI-related ulcers and painfulness were significantly improved (all p<0.01) by day 90 after treatment.	24742198
Ischemia	Stem Cell Exhaustion	Levels and values of lipoprotein-associated phospholipase A2, galectin-3, RhoA/ROCK, and endothelial progenitor cells in critical limb ischemia: pharmaco-therapeutic role of cilostazol and clopidogrel combination therapy.	24742198
Ductal Carcinoma, Malignant Neoplasms	Stem Cell Exhaustion	CD44+/CD24-low cases (cases that reveal stem cell-phenotype) in the group of invasive ductal carcinoma of Luminal A molecular subtype are almost as many as CD44+/CD24+ and CD44-/CD24+ phenotype cancers.	24743129
Malignant Neoplasms	Stem Cell Exhaustion	In this group non-stem phenotype cases are 65%, so 5 times more than stem cell phenotype cancers.	24743129
Aggressive behavior	Stem Cell Exhaustion	Stem cell phenotype positive cases are with the highest percentage represented in Luminal B and basal-like molecular subgroup that to our minds is associated with their aggressive behavior and resistance to chemotherapy.	24743129
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	With regard to the dimension of cancer the analysis of stem cell phenotype cancers showed that frequency of stem cell phenotype (CD44+/CD24-low) dramatically increases from T1 to T4 cancers.	24743129
Malignant Neoplasms	Stem Cell Exhaustion	High density of stem cell phenotype cancers in cancers with metastatic lymphatic nodes proves that presence of mentioned phenotype plays a role in progression and dissemination.	24743129
Malignant Neoplasms	Stem Cell Exhaustion	On the one hand, little amount of stem cells phenotype cancers (CD44+/CD24-low), on the other hand absence of negative cases for markers of stem cell in Her2 subtype makes us consider that come phenotype, close to stem-cell phenotype, plays the leading role in Her2 positive cases.	24743129
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells are the only cells with ability of unlimited proliferative activity and cancerous potential, thus, they participate in the growth, progression and dissemination of cancer.	24743129
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells are resistant to various forms of therapy, including chemotherapy and radiotherapy .	24743129
Malignant Neoplasms	Stem Cell Exhaustion	Relatively good prognosis and response to chemotherapy of Luminal A molecular subtype cancers are to be stipulated by lower percentage of cases with stem cells phenotype.	24743129
Degenerative polyarthritis	Stem Cell Exhaustion	The application of mesenchymal stem cells (MSCs) has been proposed as a new treatment option for OA based on the ability of these cells to differentiate into chondrocytes.	24743139
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Elevated TIM3+ hematopoietic stem cells in untreated myelodysplastic syndrome displayed aberrant differentiation, overproliferation and decreased apoptosis.	24746294
Childhood Breast Carcinoma	Stem Cell Exhaustion	Changes in mast cell number and stem cell factor expression in human skin after radiotherapy for breast cancer.	24746564
Neutropenia, Aspergillosis	Stem Cell Exhaustion	After allogeneic stem cell transplantation patients are at risk of invasive aspergillosis, especially during the period of neutropenia.	24747947
Werner Syndrome	Stem Cell Exhaustion	Telomerase protects werner syndrome lineage-specific stem cells from premature aging.	24749076
Meningitis, Cryptococcal	Stem Cell Exhaustion	Cryptococcal meningitis post autologous stem cell transplantation.	24750320
Meningitis, Cryptococcal	Stem Cell Exhaustion	Cryptococcal meningitis following autologous stem cell transplant (SCT) has been described previously in only 1 patient, 4 months post SCT and while off antifungal prophylaxis.	24750320
Disease, Conjunctival Neoplasms, Dryness of eye	Stem Cell Exhaustion	The utility of impression cytology in ocular diseases has predominantly been restricted to the diagnosis of dry eye, limbal stem cell deficiency and conjunctival neoplasias.	24750348
B-Cell Lymphomas	Stem Cell Exhaustion	R-ESHAP plus pegfilgrastim as an effective peripheral stem cell mobilization regimen for autologous stem-cell transplantation in patients with relapsed/refractory diffuse large B-cell lymphoma.	24751603
Lymphoma	Stem Cell Exhaustion	Stem cell (SC) mobilization is significantly influenced by the mobilization schedule in patients with lymphoma.	24751603
SERPINA1 wt Allele	Stem Cell Exhaustion	In conclusion, although serum AAT levels and HSPC mobilization in healthy stem cell donors are positively correlated, AAT is not an indispensable protease-inhibitor in the constitutive circulation of HSPC.	24752699
alpha 1-Antitrypsin Deficiency	Stem Cell Exhaustion	Peripheral blood hematopoietic stem and progenitor cell frequency is unchanged in patients with alpha-1-antitrypsin deficiency.	24752699
Adult Leiomyosarcoma, Fanconi Anemia	Stem Cell Exhaustion	Primary intracranial leiomyosarcoma of the torcular Herophili associated with Fanconi anemia and allogenic stem cell transplantation.	24752708
Adult Leiomyosarcoma, Fanconi Anemia	Stem Cell Exhaustion	A 12-year-old girl with Fanconi anemia presented with a primary intracranial leiomyosarcoma arising from the torcular Herophili and infiltrating the adjacent venous sinuses after previous allogenic hematopoietic stem cell transplantation.	24752708
Prion Diseases	Stem Cell Exhaustion	Since affected tissues in age-associated disorders and in pathological aging are mainly of mesenchymal origin we propose a model of human aging based on mesenchymal stem cells (hMSCs) which accumulate prelamin A.	24753226
Mutation Rate, Carcinogenesis	Stem Cell Exhaustion	Patient age is positively correlated with somatic mutation frequency, suggesting that some poly-G variants accumulate before the onset of carcinogenesis during normal division in colonic stem cells.	24753616
Prostate carcinoma	Stem Cell Exhaustion	Circulating endothelial progenitor cells in castration resistant prostate cancer: a randomized, controlled, biomarker study.	24755958
Hypoxia	Stem Cell Exhaustion	Severe hypoxia exerts parallel and cell-specific regulation of gene expression and alternative splicing in human mesenchymal stem cells.	24758227
Specialty Type - cancer, Laryngeal Squamous Cell Carcinoma	Stem Cell Exhaustion	Clinicopathological significance of cancer stem cells marked by CD133 and KAI1/CD82 expression in laryngeal squamous cell carcinoma.	24758564
Secondary Neoplasm, Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Presently, CD133 is one of the hottest markers to characterize cancer stem cells and KAI1/CD82 is reported as an important marker for the metastasis and prognosis of many cancers.	24758564
Specialty Type - cancer, Laryngeal Squamous Cell Carcinoma	Stem Cell Exhaustion	The purpose of our study is to explore the relationship between cancer stem cells (CSCs) marked by CD133 and KAI1/CD82 expression and the clinicopathological characteristics of patients with laryngeal squamous cell carcinoma (LSCC).	24758564
Fever, Abdominal Pain	Stem Cell Exhaustion	A 41-year-old man with fever and abdominal pain after stem-cell transplantation.	24758620
Lymphoma	Stem Cell Exhaustion	[Clinical analysis of 81 cases of malignant lymphoma treated with autologous hematopoietic stem cell transplantation].	24759022
Lymphoma	Stem Cell Exhaustion	To investigated the curative effect of autologous hematopoietic stem cell transplantation (ASCT) for malignant lymphoma.	24759022
Hematopoietic stem cells	Stem Cell Exhaustion	High dose of etoposide combined with G-CSF was used to mobilize peripheral hematopoietic stem cell.	24759022
Precursor cell lymphoblastic lymphoma	Stem Cell Exhaustion	[Clinical outcome of autologous stem cell transplantation as first-line treatment in 30 patients with high risk lymphoblastic lymphoma].	24759023
Precursor cell lymphoblastic lymphoma	Stem Cell Exhaustion	To investigate the treatment outcomes of autologous stem cell transplantation (ASCT) as first-line treatment in patients with high risk lymphoblastic lymphoma (LBL) and compare the effect of different induction regimen on prognosis.	24759023
Hypertensive (finding)	Stem Cell Exhaustion	Because gene microarrays had failed to detect many stem cell-associated genes, we performed quantitative real-time PCR to measure the expression of 45 primitive and tissue differentiation markers in PBMCs from healthy and hypertensive human subjects.	24759906
Coronary heart disease, Platelet aggregation	Stem Cell Exhaustion	Effects of simvastatin/ezetimibe on microparticles, endothelial progenitor cells and platelet aggregation in subjects with coronary heart disease under antiplatelet therapy.	24760119
Platelet aggregation	Stem Cell Exhaustion	Simvastatin/ezetimibe diphosphate did not change platelet aggregation, the amount of circulating endothelial and platelet microparticles, or endothelial progenitor cells.	24760119
Platelet aggregation	Stem Cell Exhaustion	Cardiovascular protection following therapy with simvastatin/ezetimibe seems restricted to lipid changes and improvement of endothelial function not affecting the release of microparticles, mobilization of endothelial progenitor cells or decreased platelet aggregation.	24760119
Degenerative polyarthritis	Stem Cell Exhaustion	Cell-based therapies have recently been proposed for the treatment of degenerative articular pathologies, such as early osteoarthritis, with an emphasis on autologous mesenchymal stem cells (MSCs), as an alternative to terminally differentiated cells.	24760577
Platelet aggregation	Stem Cell Exhaustion	to investigate hemostatic parameter changes, such as platelet aggregation, blood and plasma viscosity, prothrombin time, APTT, CRP and fibrinogen, before and after administration of stem cell therapy.	24760803
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Hemostatic status of pre and post intracoronary injection of peripheral blood stem cells in patients with recent myocardial infarction.	24760803
Heart failure	Stem Cell Exhaustion	Alteration of Notch signaling and functionality of adipose tissue derived mesenchymal stem cells in heart failure.	24767126
Vascular System Injuries	Stem Cell Exhaustion	The endothelial progenitor cell (EPC) plays an important role in repairing vascular injury.	24768407
Hemorrhagic cystitis	Stem Cell Exhaustion	Relationship of BK polyoma virus (BKV) in the urine with hemorrhagic cystitis and renal function in recipients of T Cell-depleted peripheral blood and cord blood stem cell transplantations.	24769326
Renal dysfunction, CLTC gene, Hemorrhagic cystitis	Stem Cell Exhaustion	Hematopoietic stem cell transplant (HSCT) recipients are at significant risk for BK virus (BKV) reactivation, hemorrhagic cystitis (HC), and renal dysfunction.	24769326
Specialty Type - cancer, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology	Stem Cell Exhaustion	Prognostic significance of ALDH1A1-positive cancer stem cells in patients with locally advanced, metastasized head and neck squamous cell carcinoma.	24770634
Prediabetes syndrome	Stem Cell Exhaustion	Endothelial progenitor cells as a cardiometabolic risk factor marker in prediabetes.	24776624
Atherosclerosis	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) have recently been considered as a potential novel marker of vascular integrity, atherosclerosis and cardiovascular risk.	24776624
Multiple Myeloma	Stem Cell Exhaustion	Complete response after autologous stem cell transplant in multiple myeloma.	24777883
Multiple Myeloma	Stem Cell Exhaustion	We evaluated long-term outcome of patients achieving complete response (CR) after autologous stem cell transplantation (ASCT) for multiple myeloma.	24777883
Gastrointestinal Stromal Tumors, Mesenchymal Cell Neoplasm	Stem Cell Exhaustion	Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract, believed to originate from the interstitial cells of Cajal or their stem cell-like precursors.	24778033
Gastrointestinal Stromal Tumors	Stem Cell Exhaustion	Based on antibody screening, we observed a positive correlation between the expression of GIST marker stem cell growth factor receptor, also known as tyrosine-protein kinase KIT or CD117, and STAM2 expression (r=0.387, p<0.003).	24778033
Neoplasms, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myeloid leukemia (CML) is a stem cell (SC) neoplasm characterized by the BCR/ABL1 oncogene.	24778155
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia.	24778155
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	For decades now, it is well established that chronic myeloid leukemia (CML) is a hematopoietic stem cell(HPC) disorder.	24779036
Graft-vs-Host Disease	Stem Cell Exhaustion	After allogeneic stem cell transplantation, graft-versus-host disease (GvHD) occurs through recognition of histocompatibility mismatches by donor T lymphocytes.	24781016
Muscular Dystrophy, Duchenne, Muscle Weakness	Stem Cell Exhaustion	Duchenne muscular dystrophy (DMD) patients lack dystrophin from birth; however, muscle weakness becomes apparent only at 3-5 years of age, which happens to coincide with the depletion of the muscle progenitor cell (MPC) pools.	24781208
Mantle cell lymphoma	Stem Cell Exhaustion	Allogeneic stem cell transplantation for mantle cell lymphoma--final report from the prospective trials of the East German Study Group Haematology/Oncology (OSHO).	24782119
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	This study was conducted in order to evaluate allogeneic stem cell transplantation (alloSCT) as consolidation for patients with mantle cell lymphoma (MCL).	24782119
Neoplasms	Stem Cell Exhaustion	It has been hypothesized that the hair bulge stem cells may be responsible for the broad spectrum of histological variation in these tumors.	24786577
Peroxisome biogenesis disorders	Stem Cell Exhaustion	These findings indicate the presence of a bidirectional differentiation--secretory and squamous--within the same lesion, thus supporting the hypothesis that PBD and primary EMPD may arise from a common progenitor cell.	24786579
Lymphoma, Follicular	Stem Cell Exhaustion	Long term follow-up of BEAM-autologous and BEAM-alemtuzumab allogeneic stem cell transplantation in relapsed advanced stage follicular lymphoma.	24787231
Lymphoma, Follicular	Stem Cell Exhaustion	This is an analysis in 171 patients comparing BEAM-Auto and BEAM-Allo (alemtuzumab)-hematopoietic stem cell transplantation in relapsed follicular lymphoma.	24787231
Malignant neoplasm of lung, Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cell marker Musashi-1 rs2522137 genotype is associated with an increased risk of lung cancer.	24787949
Specialty Type - cancer	Stem Cell Exhaustion	However, the potential role of genetic polymorphisms of cancer stem cell (CSC) marker genes with respect to cancer risk has not been examined.	24787949
Anemia, Sickle Cell	Stem Cell Exhaustion	First successful allogeneic hematopoietic stem cell transplantation for a sickle cell disease patient in a low resource country (Nigeria): a case report.	24792997
Anemia, Sickle Cell	Stem Cell Exhaustion	We present our first allogeneic hematopoietic stem cell transplantation (HSCT) for a 7-year-old patient with severe sickle cell anemia and debilitating right-sided hemi-paraparesis.	24792997
Anemia, Sickle Cell, Anemia	Stem Cell Exhaustion	We have successfully performed a stem cell transplanted in a 7-year-old Sickle Cell Anemia case.	24792997
Neoplasms, Medulloblastoma	Stem Cell Exhaustion	Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma.	24796395
Medulloblastoma	Stem Cell Exhaustion	Importantly JQ1 suppresses stem cell associated signaling in medulloblastoma cells and inhibits medulloblastoma tumor cell self-renewal.	24796395
Medulloblastoma	Stem Cell Exhaustion	Our work indicates that BRD4 inhibition attenuates stem cell signaling in MYC driven medulloblastoma and demonstrates the feasibility BET domain inhibition as a therapeutic approach in vivo.	24796395
Bacteremia, Multiple Myeloma	Stem Cell Exhaustion	Impact of a change in antibacterial prophylaxis on bacteremia and hospitalization rates following outpatient autologous peripheral blood stem cell transplantation for multiple myeloma.	24797543
Bacterial Infections	Stem Cell Exhaustion	Levofloxacin is routinely used for the prevention of invasive bacterial infections during autologous peripheral blood stem cell transplantation (APBSCT).	24797543
Neutropenia	Stem Cell Exhaustion	Feasibility and effectiveness of posaconazole prophylaxis in combination with micafungin bridging for patients undergoing allogeneic stem cell transplantation: a 6-yr analysis from the cologne cohort for neutropenic patients.	24798021
Mycoses	Stem Cell Exhaustion	Invasive fungal diseases (IFDs) are an important cause of morbidity and mortality in patients undergoing allogeneic stem cell transplantation (SCT).	24798021
Acute leukemia	Stem Cell Exhaustion	Who is the best hematopoietic stem-cell donor for a male patient with acute leukemia?	24798307
Li-Fraumeni Syndrome, Disease remission	Stem Cell Exhaustion	Factors significantly associated with reduced LFS included active disease, poor cytogenetics, age, year of hematopoietic stem-cell transplantation, reduced-intensity conditioning, and the use of antithymocyte globulin.	24798307
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Identification of campath-1 (CD52) as novel drug target in neoplastic stem cells in 5q-patients with MDS and AML.	24799522
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We asked whether neoplastic stem cells (NSC) in patients with MDS (n = 29) or acute myelogenous leukemia (AML; n = 62) express CD52.	24799522
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Ex vivo molecular rejuvenation improves the therapeutic activity of senescent human cardiac stem cells in a mouse model of myocardial infarction.	24801508
Self-control as a personality trait	Stem Cell Exhaustion	Examine associations between self-regulatory fatigue, quality of life, and health behaviors in patients pre- (N = 213) and 1-year post-hematopoietic stem cell transplantation (HSCT; N = 140).	24802991
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Current studies on cancer stem cells (CSCs) have verified that CSCs are the driving force behind tumor initiation and progression, suggesting that new cancer therapies may be established by effectively targeting and killing the CSCs.	24804195
Liver carcinoma, Hollings Cancer Center	Stem Cell Exhaustion	Recent studies from Asia have implicated SALL4, a stem cell marker, as useful in identifying aggressive cases of hepatocellular carcinoma (HCC), and >50% of the cases tested had upregulation by microarray or dense immunoreactivity.	24805857
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In this study, we aimed to investigate the role of stem cell factor (SCF)/C-KIT signaling in regulating the expression of tryptase in AML cells.	24806698
Multiple Myeloma	Stem Cell Exhaustion	Comparison of outcomes after autologous stem cell transplantation between myeloma patients with skeletal and soft tissue plasmacytoma.	24813053
Plasmacytoma - category, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We aimed to compare the characteristics of skeletal and soft tissue plasmacytomas and to analyze clinical outcomes and prognostic factors of autologous stem cell transplantation (ASCT) in multiple myeloma (MM) patients with plasmacytoma.	24813053
Graft-vs-Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Although older patients undergoing allogeneic hematopoietic stem cell transplantation (HCT) may experience higher morbidity, the impact of chronic graft-versus-host disease (GVHD) on quality of life (QOL) and survival outcomes for older compared with younger patients is currently unknown.	24813171
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Cancer stem cells or tumour-propagating cells (TPCs) have been identified for a number of cancers, but data pertaining to their existence in lymphoma so far remain elusive.	24814516
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	We selected 64 patients with pathological primary lung N2 SqCC who underwent surgical complete resection and investigated the expressions of four epithelial-mesenchymal transition-related markers (caveolin, clusterin, E-cadherin, ZEB2), three cancer stem cell-related markers (ALDH-1, CD44 variant6, podoplanin) of cancer cells, and four markers of CAFs (caveolin, CD90, clusterin, podoplanin) in both primary and matched metastatic lymph node tumors in the N2 area.	24814677
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Intravenous busulfan for autologous stem cell transplantation in adult patients with acute myeloid leukemia: a survey of 952 patients on behalf of the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation.	24816236
Toxic effect, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	However intravenous busulfan has more predictable pharmacokinetics and less toxicity than oral busulfan; we, therefore, retrospectively analyzed data from 952 patients with acute myeloid leukemia who received intravenous busulfan for autologous stem cell transplantation.	24816236
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Our results suggest that the use of intravenous busulfan simplifies the autograft procedure and confirm the usefulness of autologous stem cell transplantation in acute myeloid leukemia.	24816236
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	UM-SCC-103: a unique tongue cancer cell line that recapitulates the tumorigenic stem cell population of the primary tumor.	24816422
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	CD44(high) cancer stem cells from UM-SCC-103 formed tumors after flank injections in mice that reconstituted the heterogeneity of the primary tumor.	24816422
SERPINB3 wt Allele	Stem Cell Exhaustion	Moreover, HSBP1 elevated expression of stem cell markers such as CD44, CD133, ALDH and SOX2, and subsequently enhanced mammosphere formation ability, indicating it drives stem cell-like status in OSCC cells.	24816843
Leukemia, Myelomonocytic, Chronic	Stem Cell Exhaustion	Chronic myelomonocytic leukaemia (CMML) is a haematopoietic stem cell malignancy delineated by genetic heterogeneity.	24817963
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) have limited clinical therapeutic effects in older myocardial infarction (MI) patients.	24818643
Crohn Disease	Stem Cell Exhaustion	[Successful autologous haematopoietic stem cell transplantation in severe, therapy-resistant childhood Crohn's disease.	24819188
Inflammatory Bowel Diseases	Stem Cell Exhaustion	Hematopoietic stem cell transplantation has emerged as a new potential therapeutic tool for inflammatory bowel diseases.	24819188
Crohn Disease	Stem Cell Exhaustion	To the best of knowledge of the authors, this is the first report in Hungary presenting hematopoietic stem cell therapy in patient with severe Crohn's disease.	24819188
Coronary Arteriosclerosis	Stem Cell Exhaustion	Mononuclear stem cells have been studied for their potential in myocardial ischemia.	24819720
H1N1, Hematologic Neoplasms, Influenza, Communicable Diseases	Stem Cell Exhaustion	Patients with haematological malignancies receiving concurrent treatment or after allogeneic stem cell transplantation (HSCT) are considered to be at increased risk for acquiring influenza A (H1N1) infection (pH1N1) and influenza-associated complications leading to increased mortality.	24824490
ARSA wt Allele	Stem Cell Exhaustion	Moreover, after excluding patients receiving an allogeneic stem cell transplantation in first CR, MLD was associated with a shorter survival (HR, 95 % CI = 1.599, 1.026-2.492; p = 0.038).	24824767
Childhood Breast Carcinoma	Stem Cell Exhaustion	Aldehyde dehydrogenase 1 (ALDH1) has been regarded as a breast cancer stem cell marker.	24824938
Sample Size Calculation	Stem Cell Exhaustion	Seventeen patients with IP associated with SSc received autologous peripheral blood stem cell transplantation (auto-PBSCT) and were followed up using HRCT and pulmonary function tests.	24824977
Trauma	Stem Cell Exhaustion	Mobilization of CD34+-progenitor cells in patients with severe trauma.	24826895
Inflammatory Bowel Diseases	Stem Cell Exhaustion	Toll-like receptor expression in crypt epithelial cells, putative stem cells and intestinal myofibroblasts isolated from controls and patients with inflammatory bowel disease.	24828022
Mantle cell lymphoma	Stem Cell Exhaustion	Intensive chemotherapy and consolidation with high dose therapy and autologous stem cell transplant in patients with mantle cell lymphoma.	24828864
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	A bortezomib-containing regimen followed by high-dose therapy and autologous stem cell transplant (ASCT) is considered the standard of care for front-line therapy in younger patients with newly diagnosed multiple myeloma (MM).	24828869
Depression, CTCAE, Anxiety Disorders, Coma, Post-Head Injury, Physical and emotional exhaustion state	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) is curative in several life-threatening pediatric diseases but may affect children and their families inducing depression, anxiety, burnout symptoms, and post-traumatic stress symptoms, as well as post-traumatic growth (PTG).	24830676
Cytomegalovirus Infections	Stem Cell Exhaustion	The clinical and financial burden of pre-emptive management of cytomegalovirus disease after allogeneic stem cell transplantation-implications for preventative treatment approaches.	24831837
Cytomegalovirus Infections, Toxic effect, Communicable Diseases	Stem Cell Exhaustion	Although cytomegalovirus (CMV) infection after allogeneic stem cell transplantation (SCT) is rarely fatal, the management of CMV by pre-emptive medication for viral reactivation has toxicity and carries a financial burden.	24831837
Specialty Type - cancer, Esophageal Neoplasms	Stem Cell Exhaustion	It has been suggested that markers associated with cancer stem cells (CSC) may play a role in esophageal cancer.	24833101
Infection, Immune System Diseases	Stem Cell Exhaustion	B-cell immune dysfunction contributes to the risk of severe infections after allogeneic hematopoietic stem cell transplantation (allo-HSCT).	24833353
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	These high rates of locoregional recurrence are potentially influenced by the contribution of radioresistant cancer stem cells to these cancers.	24833589
Rheumatoid Arthritis	Stem Cell Exhaustion	Neutralisation of CCL28 in RA SF or blockade of CCR10 on human endothelial progenitor cells (EPCs) significantly reduced SF-induced endothelial migration and capillary formation, demonstrating that ligation of joint CCL28 to endothelial CCR10+ cells is involved in RA angiogenesis.	24833787
Cholangiocarcinoma	Stem Cell Exhaustion	Markers of the stem cell phenotype in cholangiocarcinoma, HepPar1 and CK20, were negative in all cases.	24837095
Acute leukemia	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) is the mainstay of treatment for adults with acute leukemia.	24837891
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Upfront allogeneic stem cell transplantation after reduced-intensity/nonmyeloablative conditioning for patients with myelodysplastic syndrome: a study by the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire.	24838178
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Cytoreduction before allogeneic stem cell transplantation (allo-SCT) for patients with myelodysplastic syndromes remains a debatable issue.	24838178
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Acute and chronic myeloid leukemia are initiated and sustained by a small, self-renewing population of leukemic stem cells, which produce progeny of a heterogeneous population of progenitor cells.	24839815
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease (aGVHD) remains a life-threatening complication of hematopoietic stem cell transplantation (HSCT) therefore limiting its application.	24840443
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	A multicompartment mathematical model of cancer stem cell-driven tumor growth dynamics.	24840956
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	As a central tenet of the so-called cancer stem cell hypothesis, most cancer cells have only a limited lifespan, and thus cannot initiate or reinitiate tumors.	24840956
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	We show that overall tumor progression rate during the exponential growth phase is identical to the growth rate of the cancer stem cell compartment.	24840956
Neoplasms	Stem Cell Exhaustion	Tumors with identical stem cell proportions, however, can have different growth rates, dependent on the proliferation kinetics of all participating cell populations.	24840956
Longevity, Specialty Type - cancer	Stem Cell Exhaustion	Longevity and clonogenicity are properties unique to the subpopulation of cancer stem cells.	24840956
Specialty Type - cancer	Stem Cell Exhaustion	To understand the implications of the population structure suggested by this hypothesis--a hierarchy consisting of cancer stem cells and progeny non-stem cancer cells which experience a reduction in their remaining proliferation capacity per division--we set out to develop a mathematical model for the development of the aggregate population.	24840956
LMNA wt Allele	Stem Cell Exhaustion	In this study, using SMCs differentiated from HGPS induced pluripotent stem cells, we show that HGPS SMCs exhibit a profound proliferative defect, which is primarily caused by caspase-independent cell death.	24843141
Specialty Type - cancer	Stem Cell Exhaustion	These findings provide a valuable mechanistic basis for studying the process of asymmetric inheritance in mammalian cells, including cells potentially undergoing polar divisions, such as differentiating stem cells and cancer cells.	24843142
Antilymphocyte Serum	Stem Cell Exhaustion	Here we show that intrathecal transplantation of human motor neurons derived from neural stem cells (NSCs) in spinal cord of the SOD1G93A mouse ALS model delayed disease onset and extended life span of the animals.	24844281
HLA Mismatch, Graft-vs-Host Disease	Stem Cell Exhaustion	Mismatch on glutathione S-transferase T1 increases the risk of graft-versus-host disease and mortality after allogeneic stem cell transplantation.	24844856
Hematologic Neoplasms	Stem Cell Exhaustion	Predictive value of risk assessment scores in patients with hematologic malignancies undergoing reduced-intensity conditioning allogeneic stem cell transplantation.	24845702
Toxic effect	Stem Cell Exhaustion	Reduced-intensity conditioning allogeneic stem cell transplantation (RIC allo-SCT) is associated with less toxicity and is used for older patients.	24845702
leukemia	Stem Cell Exhaustion	Leukocyte interleukin-3 receptor a (CD123) is regarded as a marker of leukemia stem cells.	24846193
Neurobehavioral problems	Stem Cell Exhaustion	Cross-sectional study of patient-reported neurobehavioral problems following hematopoietic stem cell transplant and health-related quality of life.	24846770
Neurobehavioral problems, Impaired cognition, Apathy	Stem Cell Exhaustion	Although hematopoietic stem cell transplant (HSCT) patients may experience neurocognitive impairment, experiences of neurobehavioral problems (including apathy and disinhibition) are understudied.	24846770
Specialty Type - cancer	Stem Cell Exhaustion	A strong debate in the Literature is open about a higher risk of cancer relapse caused by growth factors produced by adipocyte stem cells after their engraftment in the recipient tissue.	24847895
Specialty Type - cancer	Stem Cell Exhaustion	New insights into skin stem cell aging and cancer.	24849235
Inflammation	Stem Cell Exhaustion	Recently, we identified novel roles of Substance-P (SP) in the suppression of the injury-mediated inflammation and also in stem cell mobilization.	24849674
Osteoporosis, melphalan/prednisone protocol	Stem Cell Exhaustion	Therefore, this comparative study suggests that SP, even after long-term usage of effective dose, may not cause side effects such as osteoporosis in comparison to that of DEX and MP and can be developed as an anti-inflammatory agent and/or stem cell mobilizer for long-term treatment.	24849674
Malignant neoplasm of salivary gland	Stem Cell Exhaustion	Most importantly, WIF1 significantly diminished the number of salivary gland cancer stem cells and the anchorage-independent cell growth.	24853424
Mammary adenocarcinoma	Stem Cell Exhaustion	We further show that the knockdown of NDY1 in mammary adenocarcinoma cell lines decreased the number, size, and replating efficiency of mammospheres and downregulated the stem cell markers ALDH and CD44, while upregulating CD24.	24853546
Childhood Breast Carcinoma	Stem Cell Exhaustion	NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells.	24853546
Adenocarcinoma, Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Together, these findings suggest that NDY1 is required for the self-renewal of cancer stem cells and are in agreement with additional findings showing that tumor cells in which NDY1 was knocked down undergo differentiation and a higher number of them is required to induce mammary adenocarcinomas, upon orthotopic injection in animals.	24853546
Graft-vs-Host Disease, Hematopoietic stem cells, Epithelial Damage	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HSCT) is widely used to treat hematopoietic cell disorders but is often complicated by graft-versus-host disease (GVHD), which causes severe epithelial damage.	24855210
Multiple Myeloma	Stem Cell Exhaustion	This multicenter, open-label phase 2 trial determined the safety and efficacy of carfilzomib, a novel and irreversible proteasome inhibitor, in combination with cyclophosphamide and dexamethasone (CCyd) in patients with newly diagnosed multiple myeloma (NDMM) >=65 years of age or who were ineligible for autologous stem cell transplantation.	24855212
Specialty Type - cancer	Stem Cell Exhaustion	In unadjusted analyses, lack of FP therapy prior to cancer treatment, older age, partnered relationship, higher income, no history of stem cell or bone marrow transplant, and longer duration of survivorship were significantly associated with pregnancy attempts.	24859010
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5), a marker of adult stem cells and cancer stem cells, plays important roles in tumor progression.	24859092
Graft-vs-Host Disease	Stem Cell Exhaustion	CD4 regulatory T cells play a critical role in establishment of immune tolerance and prevention of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.	24859877
Chronic graft-versus-host disease	Stem Cell Exhaustion	Mitochondrial priming is increased after hematopoietic stem cell transplantation in all T-cell subsets and particularly in patients with chronic graft-versus-host disease.	24859877
Mitochondrial Inheritance	Stem Cell Exhaustion	Decreased expression of BCL2 and increased expression of BIM, a mitochondrial cell death activator protein, in regulatory T cells contributes to increased mitochondrial priming in this T-cell subset but additional factors likely contribute to increased mitochondrial priming following hematopoietic stem cell transplantation.	24859877
Neutropenia, Graft-vs-Host Disease, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Posaconazole (PSC) is currently recommended as primary prophylaxis in neutropenic patients with acute myeloid leukaemia (AML) and in allogenic haematopoietic stem cell transplantation (AHSCT) recipients with graft-versus-host disease (GVHD).	24861577
Graft-vs-Host Disease	Stem Cell Exhaustion	After allogeneic stem cell transplantation (SCT), a reliable diagnosis of acute graft versus host disease (aGvHD) is essential for an early and successful treatment.	24863887
Lymphoproliferative Disorders	Stem Cell Exhaustion	Utility of quantitative EBV DNA measurements in cerebrospinal fluid for diagnosis and monitoring of treatment of central nervous system EBV-associated post-transplant lymphoproliferative disorder after allogenic hematopoietic stem cell transplantation.	24866354
Post-transplant lymphoproliferative disorder, Lymphoproliferative Disorders	Stem Cell Exhaustion	Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disorder (PTLD) after hematopoietic stem cell transplantation (HSCT) is a rare but life- threatening condition.	24866354
Extrapulmonary Small Cell Carcinoma, Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	The implications are either in vivo existence of Oct4 positive putative cancer stem cells in ESCC or acquisition of cancer stem cell properties by tumor cells as a response to treatment given, resulting ultimately an uncontrolled cell proliferation and treatment failure.	24870750
Neoplasms	Stem Cell Exhaustion	It has been hypothesized that Oct4 positive radioresistant stem cells may be responsible for tumor recurrence.	24870750
Extrapulmonary Small Cell Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Our observations highlighted a possible role of Oct4 in identifying putative cancer stem cells in ESCC pathobiology and response to treatment.	24870750
Hodgkin Disease	Stem Cell Exhaustion	FDG-PET adapted sequential therapy with brentuximab vedotin and augmented ICE followed by autologous stem cell transplant for relapsed and refractory Hodgkin lymphoma.	24870873
Stable chronic Graft vs Host Disease, Systemic Scleroderma, Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic graft-versus-host disease (cGvHD) after hematopoietic stem cell transplantation may have clinical fibrotic features, whose pathogenesis may be similar with systemic sclerosis.	24873781
Stable chronic Graft vs Host Disease	Stem Cell Exhaustion	Sera from 87 patients including 45 extensive cGvHD and 42 hematopoietic stem cell transplantation patients without cGvHD were retrospectively analyzed for the presence of AT1R-AA using an enzymatic immunoassay.	24873781
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	A 63-year-old man with a 1-year course of IgA-l multiple myeloma (MM) and a history of autologous stem cell transplantation presented with multiple nontender, nodular violaceous skin lesions that were located predominantly on his trunk.	24873802
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Differential sensitivity of Glioma stem cells to Aurora kinase A inhibitors: implications for stem cell mitosis and centrosome dynamics.	24879067
Glioblastoma Multiforme Pathway, Neoplasms, Adult Glioblastoma, Specialty Type - cancer	Stem Cell Exhaustion	Glioma stem-cell-like cells are considered to be responsible for treatment resistance and tumour recurrence following chemo-radiation in glioblastoma patients, but specific targets by which to kill the cancer stem cell population remain elusive.	24879067
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	In this study we have analysed specific features of glioma stem cell mitosis.	24879067
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Accordingly, glioma stem cell survival appeared to be strongly dependent on Aurora A activity.	24879067
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	We found that glioma stem cells appear to be highly prone to undergo aberrant cell division and polyploidization.	24879067
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Unlike differentiated cells, glioma stem cells responded to moderate Aurora A inhibition with spindle defects, polyploidization and a dramatic increase in cellular senescence, and were selectively sensitive to Aurora A and Plk1 inhibitor treatment.	24879067
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Our study proposes inhibition of centrosomal kinases as a novel strategy to selectively target glioma stem cells.	24879067
Malignant Neoplasms, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Abnormal apoptosis is one of the hallmarks of cancers including acute myeloid leukemia (AML), as it plays a pivotal role in precisely maintaining self-renewal, proliferation, and differentiation properties of hematopoietic stem cells (HSCs).	24879622
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Mobilization-driven postconsolidation therapy in elderly patients with acute myeloid leukemia: feasibility and efficacy of autologous stem cell transplantation versus low-dose gemtuzumab ozogamicin.	24880020
Postoperative Complications	Stem Cell Exhaustion	This prospective observational trial studied the mobilization of endothelial progenitor cells (EPCs) in response to exercise in association with postoperative complications.	24880828
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Relapse in acute myeloid leukemia (AML) after chemotherapy reflects the persistence of resistant leukemia stem cells (LSCs).	24884314
Childhood Breast Carcinoma	Stem Cell Exhaustion	We investigated the expression status of AGBL2 and its inhibitor latexin in breast cancer stem cells and its clinical implications in order to lay a foundation for managing breast cancer.	24884516
Infection	Stem Cell Exhaustion	Mannose-binding lectin gene variants and infections in patients receiving autologous stem cell transplantation.	24886325
Infection	Stem Cell Exhaustion	Serious infections are common in patients undergoing autologous stem cell transplantation (ASCT) mainly because of the effects of immunosuppression.	24886325
Specialty Type - cancer, Malignant neoplasm of ovary, Neoplasms	Stem Cell Exhaustion	Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden.	24886434
Specialty Type - cancer, Malignant neoplasm of ovary, Neoplasms	Stem Cell Exhaustion	We have previously demonstrated that a single short-term treatment of ovarian cancer cells with chemotherapy in vitro resulted in a cancer stem cell (CSC)-like enriched residual population which generated significantly greater tumor burden compared to the tumor burden generated by control untreated cells.	24886434
Lymphoma, Gastrointestinal mucositis, Multiple Myeloma	Stem Cell Exhaustion	Usefulness and safety of oral cryotherapy in the prevention of oral mucositis after conditioning regimens with high-dose melphalan for autologous stem cell transplantation for lymphoma and myeloma.	24889275
Morular Metaplasia of the Endometrium, Lymphoid neoplasm, Multiple Myeloma	Stem Cell Exhaustion	This retrospective cohort study analyzes the impact of oral cryotherapy (OC) or room temperature saline rinses on the prevention of OM in patients with multiple myeloma (MM) or lymphoid neoplasias submitted to autologous stem cell transplantation (ASCT) in a single center.	24889275
Radiation Damage	Stem Cell Exhaustion	Dose-volume histogram (DVH) analysis was performed for specific regions of interest that were considered potential targets of radiation damage, including the thalamus, temporal lobes, nasopharynx, olfactory groove, frontal pole, and periventricular stem cell niche.	24890354
Peripheral Blood Stem Cells, Lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) is a potentially curative treatment of lymphoma, but peripheral blood stem cell (PBSC) mobilization fails in some patients.	24890497
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Two CLL patients that achieved long-term remission following allogeneic hematopoietic stem cell transplantation were monitored for CD8(+) T-cell responses against predicted or confirmed HLA-binding peptides.	24891321
Chronic diarrhea, Chronic graft-versus-host disease	Stem Cell Exhaustion	In evaluating a patient presenting with chronic diarrhea more than 100 days after BMT, one must consider a serious underlying illness such as chronic GVHD because it is a major cause of morbidity and mortality of allogeneic stem cell transplantation.	24891601
Liver carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial-mesenchymal transition in hepatocellular carcinoma.	24892648
Specialty Type - cancer, Hollings Cancer Center	Stem Cell Exhaustion	In this study, we aimed to clarify the mechanism underlying the crosstalk between TAMs and cancer stem cells (CSCs) in HCC.	24892648
Multiple Myeloma	Stem Cell Exhaustion	Bone marrow plasma cell assessment before peripheral blood stem cell mobilization in patients with multiple myeloma undergoing autologous stem cell transplantation.	24895639
Liver carcinoma	Stem Cell Exhaustion	Thus, we performed autologous stem cell transplantation for rapid liver regeneration with extensive hepatectomy in hepatocellular cancer patients.	24895813
Graft-vs-Host Disease	Stem Cell Exhaustion	Sirolimus-based graft-versus-host disease prophylaxis promotes the in vivo expansion of regulatory T cells and permits peripheral blood stem cell transplantation from haploidentical donors.	24897508
Hematologic Neoplasms	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) from human leukocyte antigen (HLA) haploidentical family donors is a promising therapeutic option for high-risk hematologic malignancies.	24897508
Graft-vs-Host Disease, Terminal illness	Stem Cell Exhaustion	Here we explored in 121 patients, mostly with advanced stage diseases, a sirolimus-based, calcineurin-inhibitor-free prophylaxis of graft-versus-host disease (GvHD) to allow the infusion of unmanipulated peripheral blood stem cell (PBSC) grafts from partially HLA-matched family donors (TrRaMM study, Eudract 2007-5477-54).	24897508
Neoplasms, Gallbladder adenocarcinoma	Stem Cell Exhaustion	This case raises the hypothesis that the so-called "hepatoid adenocarcinoma of the gallbladder" may presently be better understood as a neoplasm derived from hepatobiliary stem/progenitor cells.	24897774
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	A small subpopulation of cancer stem cells (CSCs) possessing a self-renewing capacity is reported to be responsible for tumor recurrence and therapeutic resistance.	24898358
Graft-vs-Host Disease	Stem Cell Exhaustion	Allogeneic peripheral blood stem cell transplantation using reduced-intensity conditioning in an outpatient setting in ABO-incompatible patients: are survival and graft-versus-host disease different?	24898453
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GVHD) is a major cause of morbimortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT).	24898453
Graft-vs-Host Disease, Stable chronic Graft vs Host Disease	Stem Cell Exhaustion	Using this type of peripheral blood stem cell transplantation, minor ABO-mismatched allo-HSCT was associated with a higher incidence of aGVHD and cGVHD and with increased survival, albeit with no significance.	24898453
Thrombocytosis	Stem Cell Exhaustion	Moreover, essential thrombocythaemia patient B cells facilitated megakaryocyte differentiation when co-cultured with CD34+ haematopoietic stem cells.	24898769
Malignant Neoplasms, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukemia (AML), caused by abnormal proliferation and accumulation of hematopoietic progenitor cells, is one of the most common malignancies in adults.	24901999
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	To elucidate this, CD34(+) stem cell and progenitor cell subpopulations were isolated by fluorescence-activated cell sorting (FACS), and their content of residual Philadelphia positive (Ph(+) ) cells was evaluated in 17 CML patients (major molecular response, n = 6; 4-log reduction in BCR-ABL1 expression (MR(4) ), n = 11) using both sensitive qPCR and interphase fluorescence in situ hybridization (iFISH).	24903628
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	This approach demonstrates a clinically applicable manner of assessing residual disease at the stem cell level in CML patients in MR(4) , and may enable early and safe identification of candidates for tyrosine kinase inhibitor withdrawal.	24903628
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Cell sorting enables interphase fluorescence in situ hybridization detection of low BCR-ABL1 producing stem cells in chronic myeloid leukaemia patients beyond deep molecular remission.	24903628
Acute GVH disease	Stem Cell Exhaustion	[The impact of donor naive and memory T cell subsets on patient outcome following allogeneic stem cell transplantation: relationship between infused donor CD4+/CCR7+ T cell subsets and acute graft-versus-host disease].	24906571
Specialty Type - cancer	Stem Cell Exhaustion	The most upregulated genes included epithelial cell adhesion molecule (EpCAM), a biomarker of cancer stem cells (CSC).	24909871
leukemia, Aplastic Anemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Outcome of allogeneic stem cell transplantation for patients transformed to myelodysplastic syndrome or leukemia from severe aplastic anemia: a report from the MDS Subcommittee of the Chronic Malignancies Working Party and the Severe Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation.	24910382
PAFAH1B1 wt Allele, Aplastic Anemia, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	One hundred and forty patients who had undergone hematopoietic stem cell transplantation (HSCT) for myelodysplastic syndrome (MDS) or acute myelogenous leukemia (AML) transformation after treatment of severe aplastic anemia (SAA) were identified in the European Group for Blood and Marrow Transplantation (EBMT) database.	24910382
Malignant neoplasm of stomach, Specialty Type - cancer	Stem Cell Exhaustion	To evaluate the frequency of cancer stem cell marker CD44 combined CD324 expression in gastric cancer specimens and association of the expression with survival of gastric cancer patients.	24910454
Hematologic Neoplasms	Stem Cell Exhaustion	A biosimilar G-CSF (Zarzio((r))) demonstrated similar efficacy and safety as the reference originator G-CSF (Neupogen((r))) in hematopoietic stem cell mobilization in patients with haematological malignancies.	24911076
Degenerative polyarthritis	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) are a promising cell type for the repair of damaged cartilage in osteoarthritis (OA).	24911520
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Stem cell transplantations and donor lymphocyte infusions are promising immunotherapies to cure acute myeloid leukemia (AML).	24911794
Fibrosis Assessment	Stem Cell Exhaustion	Improvement in Spinal Cord Injury-Induced Bladder Fibrosis Using Mesenchymal Stem Cell Transplantation Into the Bladder Wall.	24912020
Stanford Cancer Institute, Spinal Cord Injuries, Bladder dysfunction	Stem Cell Exhaustion	Experiments on spinal cord injury (SCI) have largely focused on the transplantation of stem cells into injured spinal cords for motor recovery while neglecting to investigate bladder dysfunction.	24912020
Stanford Cancer Institute	Stem Cell Exhaustion	The present study was performed to investigate the effect of B10 human mesenchymal stem cells (hMSCs) directly transplanted into the bladder wall of SCI rats and to determine whether they are capable of inhibiting collagen deposition and improving cystometric parameters in SCI rats.	24912020
Chronic myeloproliferative disorder, Primary Myelofibrosis, Leukemia, Myelocytic, Acute, PMF Regimen	Stem Cell Exhaustion	In studies designed to define neoplastic stem cells of primary myelofibrosis (PMF), a myeloproliferative neoplasm characterized by profound disruption of the hematopoietic microenvironment, we observed a high frequency of acute myeloid leukemia (AML) in NSG mice.	24912157
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Extracorporeal photopheresis (ECP) constitutes a promising treatment for patients with steroid-refractory acute graft-versus-host disease (aGvHD) after allogeneic stem cell transplantation and for patients with graft rejection after solid organ transplantation (SOT).	24913503
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Allogeneic stem cell transplant in patients with chronic lymphocytic leukemia with 17p deletion: consult-transplant versus consult- no-transplant analysis.	24913509
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Allogeneic stem cell transplant (alloSCT) can overcome the adverse prognosis of chronic lymphocytic leukemia with 17p deletion (17p- CLL).	24913509
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Prediction of non-relapse mortality in recipients of reduced intensity conditioning allogeneic stem cell transplantation with AML in first complete remission.	24913728
Tears body substance	Stem Cell Exhaustion	Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study.	24913770
Renal dysfunction	Stem Cell Exhaustion	The purpose of this study was to retrospectively evaluate the incidence of delayed renal dysfunction after total body irradiation (TBI) in long-term survivors of TBI/hematopoietic stem cell transplantation (HSCT).	24914103
Sepsis	Stem Cell Exhaustion	His elder brother exhibited a similar clinical presentation and died from sepsis after hematopoietic stem cell transplantation.	24914498
herpesvirus 3, human	Stem Cell Exhaustion	One-year prophylaxis with acyclovir has been shown to effectively prevent varicella-zoster virus (VZV) reactivation after allogeneic hematopoietic stem cell transplantation (HSCT) in a cohort that underwent transplantation in the beginning of the 2000s.	24914821
melanoma	Stem Cell Exhaustion	CTCs were captured by targeting the melanoma associated markers MCSP and MCAM as well as the melanoma stem cell markers ABCB5 and CD271.	24915896
Angioimmunoblastic Lymphadenopathy	Stem Cell Exhaustion	Cyclosporine treatment of angioimmunoblastic T-cell lymphoma relapsed after an autologous hematopoietic stem cell transplant.	24918480
Autoimmune hemolytic anemia, Angioimmunoblastic Lymphadenopathy	Stem Cell Exhaustion	Here, we report a case of 53-year-old woman with angioimmunoblastic T-cell lymphoma who underwent high-dose chemotherapy with an autologous hematopoietic stem cell transplant after several cycles of chemotherapy, but soon relapsed with severe autoimmune hemolytic anemia.	24918480
Angioimmunoblastic Lymphadenopathy	Stem Cell Exhaustion	Thus, we conclude that cyclosporine has an effect in relapsed angioimmunoblastic T-cell lymphoma after an autologous hematopoietic stem cell transplant.	24918480
Cerebral Infarction	Stem Cell Exhaustion	Long-term MRI cell tracking after intraventricular delivery in a patient with global cerebral ischemia and prospects for magnetic navigation of stem cells within the CSF.	24919061
Cerebral Infarction	Stem Cell Exhaustion	After approval by our Institutional Review Board, an 18-month-old patient, diagnosed as being in a vegetative state due to global cerebral ischemia, underwent cell transplantation to the frontal horn of the lateral ventricle, with umbilical cord blood-derived stem cells labeled with superparamagnetic iron oxide (SPIO) contrast agent.	24919061
Colorectal Carcinoma, Specialty Type - cancer, Cytogenetic Complete Response	Stem Cell Exhaustion	CD133 and CD44 are putative cancer stem cell (CSC) markers in colorectal cancer (CRC).	24921913
Specialty Type - cancer, Cytogenetic Complete Response	Stem Cell Exhaustion	Cancer stem cell marker expression was examined in both xenografts and a complementary DNA library compiled from 167 CRC patient samples.	24921913
Bulbo-Spinal Atrophy, X-Linked	Stem Cell Exhaustion	Stem cell-derived motor neurons from spinal and bulbar muscular atrophy patients.	24925468
Bulbo-Spinal Atrophy, X-Linked	Stem Cell Exhaustion	Induced pluripotent stem cells from spinal and bulbar muscular atrophy patients provide a useful model for understanding the disease mechanism and designing effective therapy.	24925468
Bulbo-Spinal Atrophy, X-Linked	Stem Cell Exhaustion	SBMA stem cells present new insights into the disease, and the observations of reduced androgen receptor levels, repeat instability, and reduced HDAC6 provide avenues for further investigation of the disease mechanism and development of effective therapy.	24925468
Multiple Myeloma	Stem Cell Exhaustion	Pharmacoeconomic impact of up-front use of plerixafor for autologous stem cell mobilization in patients with multiple myeloma.	24927717
Bone neoplasms	Stem Cell Exhaustion	Age-specific bone tumour incidence rates are governed by stem cell exhaustion influencing the supply and demand of progenitor cells.	24927913
Neoplasms	Stem Cell Exhaustion	To fill this gap, I hypothesize that neoplasms preferentially arise when stem cell exhaustion creates a short supply of progenitor cells at ages of high proliferative demand.	24927913
Osteosarcoma, Cartilaginous exostosis	Stem Cell Exhaustion	Results show that progenitor cell demand-to-supply ratios are a good risk indicator, exhibiting similar trends to the unimodal and bimodal age distributions of osteochondroma and osteosarcoma, respectively.	24927913
Multiple Myeloma	Stem Cell Exhaustion	Combination of bortezomib, thalidomide, and dexamethasone (VTD) as a consolidation therapy after autologous stem cell transplantation for symptomatic multiple myeloma in Japanese patients.	24928523
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Consolidation therapy for patients with multiple myeloma (MM) has been widely adopted to improve treatment response following autologous stem cell transplantation.	24928523
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Fractalkine levels are elevated early after PCI-treated ST-elevation myocardial infarction; no influence of autologous bone marrow derived stem cell injection.	24930044
Acute myocardial infarction	Stem Cell Exhaustion	There is limited knowledge of fractalkine levels during acute myocardial infarction (AMI) and stem cell treatment.	24930044
Angina Pectoris, Acute myocardial infarction	Stem Cell Exhaustion	We examined fractalkine levels at different time points by enzyme-linked immunosorbent assay (ELISA) in 20 patients with AMI, and 10 patients with stable angina pectoris (AP) undergoing percutaneous coronary intervention (PCI), and in 100 patients included in the randomized Autologous Stem-Cell Transplantation in Acute Myocardial Infarction (ASTAMI) trial.	24930044
Infectious Lung Disorder	Stem Cell Exhaustion	Pulmonary Nocardia nova infection after allogeneic hematopoietic stem cell transplantation.	24930664
Graft-vs-Host Disease, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We herein report the case of a 68-year-old man with a history of allogeneic hematopoietic stem cell transplantation for acute myelocytic leukemia in whom graft-versus-host disease (GVHD) developed in the gastrointestinal tract and liver five months after transplantation.	24930664
Wiskott-Aldrich Syndrome, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Successful treatment of non-Hodgkin's lymphoma using R-CHOP in a patient with Wiskott-Aldrich syndrome followed by a reduced-intensity stem cell transplant.	24930759
Bacteremia	Stem Cell Exhaustion	Impact of peri-transplant vancomycin and fluoroquinolone administration on rates of bacteremia in allogeneic hematopoietic stem cell transplant (HSCT) recipients: a 12-year single institution study.	24931578
Malignant melanoma of conjunctiva, Trauma	Stem Cell Exhaustion	Four consecutive patients with unilateral partial (2 eyes) and total (2 eyes) limbal stem cell deficiency secondary to ocular surface burns (2 eyes), trauma (1 eye) and conjunctival melanoma treatment (1 eye) underwent modified simple limbal epithelial transplantation at Bascom Palmer Eye Institute.	24932987
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is recommended for patients with high-risk acute myeloid leukemia (AML).	24933658
Coronary Arteriosclerosis	Stem Cell Exhaustion	Hypermethylation of DDAH2 promoter contributes to the dysfunction of endothelial progenitor cells in coronary artery disease patients.	24934151
Coronary Arteriosclerosis	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPCs) may be a biomarker for vascular function and cardiovascular risk in patients with coronary artery disease (CAD).	24934151
Prediabetes syndrome, Diabetes, Acute myocardial infarction	Stem Cell Exhaustion	Reduced levels of circulating endothelial progenitor cells in acute myocardial infarction patients with diabetes or pre-diabetes: accompanying the glycemic continuum.	24934236
Carcinogenesis	Stem Cell Exhaustion	Recently, the SRY-related transcription factor SOX2 has been widely reported to be involved in multiple pathophysiological diseases, including maintenance of stem cell characteristics and carcinogenesis.	24937695
Mycoses	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplant patients are at risk of invasive fungal infections and prophylaxis with azole agents is common practice.	24938293
Cessation of life	Stem Cell Exhaustion	The differences between groups in relapse incidence, non-relapse mortality, and death rate during induction were not statistically significant, although the older-adolescents trended towards a higher frequency of having stem-cell transplantation during the first remission.	24938380
Hematologic Neoplasms, Metabolic Syndrome X, Mitral Valve Stenosis	Stem Cell Exhaustion	The relationship between treatment for hematologic malignancies and risk of developing metabolic syndrome (MS) is controversial; in addition, metabolic changes following hematopoietic stem cell transplantation (HSCT) is an area of growing interest.	24940820
Specialty Type - cancer	Stem Cell Exhaustion	Peripheral blood stem cell (PBSC) rescue following myeloablative therapy is a mainstay of cancer therapy.	24941931
Autoimmune state	Stem Cell Exhaustion	Does Teno Torque Virus Induce Autoimmunity After Hematopoietic Stem Cell Transplantation?	24942030
Dermatitis, Atopic, Leukemia, Myelocytic, Acute, Autoimmune Chronic Hepatitis	Stem Cell Exhaustion	We report here a case of an 11-month-old infant affected by acute myeloid leukemia who underwent hematopoietic stem cell transplantation, and after 6 months had autoimmune hepatitis and atopic dermatitis.	24942030
Muscular Dystrophy	Stem Cell Exhaustion	One of the questions to be addressed is whether stem cells from distinct sources have comparable clinical effects when injected in murine or canine muscular dystrophy animal models.	24943487
Graft-vs-Host Disease	Stem Cell Exhaustion	Mycophenolate mofetil use after unrelated hematopoietic stem cell transplantation for prophylaxis and treatment of graft-vs.-host disease in adult patients in Japan.	24943923
Graft-vs-Host Disease	Stem Cell Exhaustion	Our previous study of 301 patients who received hematopoietic stem cell transplantation (HSCT) from related donors demonstrated the efficacy of mycophenolate mofetil (MMF) for prophylaxis and treatment of graft-vs.-host disease (GVHD).	24943923
Lymphoma	Stem Cell Exhaustion	ICE/R-ICE (ifosfamide, carboplatin, and etoposide without or with rituximab) chemotherapy followed by autologous stem cell transplantation is an established regimen in refractory/relapsed lymphoma.	24944079
Primary central nervous system lymphoma	Stem Cell Exhaustion	Upfront autologous stem-cell transplantation with melphalan, cyclophosphamide, etoposide, and dexamethasone (LEED) in patients with newly diagnosed primary central nervous system lymphoma.	24947495
Primary central nervous system lymphoma	Stem Cell Exhaustion	We report 13 consecutive patients with PCNSL for whom upfront melphalan, cyclophosphamide, etoposide, and dexamethasone (known as LEED) followed by autologous stem-cell transplantation (ASCT) was planned at the Anjo Kosei Hospital.	24947495
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Compared with growth factor (G) alone, the combination of G with plerixafor (G + P) increases peripheral blood CD34+ count (PB-CD34+) and improves CD34+ collection yield (yCD34+) in multiple myeloma and lymphoma patients undergoing autologous hematopoietic progenitor cell (AHPC) mobilization.	24947954
Bone marrow hypocellularity, Aneuploidy	Stem Cell Exhaustion	As telomeres protect chromosomes from instability, it is highly plausible that this genetic lesion was responsible for the patient's hematological manifestations, including marrow failure and aneuploidy in the hematopoietic stem cell compartment.	24948335
Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy plus autologous stem-cell transplantation as consolidation therapy in patients with relapsed multiple myeloma after previous autologous stem-cell transplantation (NCRI Myeloma X Relapse [Intensive trial]): a randomised, open-label, phase 3 trial.	24948586
Relapse multiple myeloma	Stem Cell Exhaustion	Relapsed multiple myeloma has no standard treatment, and the role of autologous stem-cell transplantation (ASCT) has not been fully defined.	24948586
Colon Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	CD133/CD166/Ki-67 triple immunofluorescence assessment for putative cancer stem cells in colon carcinoma.	24949608
Malignant tumor of colon, Secondary Neoplasm	Stem Cell Exhaustion	The existence of drug-resistant colon cancer stem cells is thought to be one of the most important reasons behind treatment failure in colon cancer, their existence putatively leading to metastasis and recurrences.	24949608
Toxic effect	Stem Cell Exhaustion	The CloB2A2 regimen prior to allogeneic stem cell transplantation is feasible, allowing for full engraftment and low toxicity.	24951467
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	XIAP inhibitors induce differentiation and impair clonogenic capacity of acute myeloid leukemia stem cells.	24952669
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	XIAP inhibition differentially impaired cell viability of the most primitive AML blasts and reduced clonogenic capacity of AML cells, sparing healthy mature blood and hematopoietic stem cells.	24952669
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Cytogenetics, donor type, and use of hypomethylating agents in myelodysplastic syndrome with allogeneic stem cell transplantation.	24953017
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We investigated the impact of patient and disease characteristics, including cytogenetics, previous therapy, and depth of response, on the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) for patients with myelodysplastic syndrome (MDS).	24953017
Hemorrhagic cystitis	Stem Cell Exhaustion	Fibrin glue therapy for severe hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation.	24953019
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation (ASCT) is a curative option alternative to allogeneic transplantation for patients with acute myeloid leukemia (AML).	24954546
Bronchiolitis Obliterans	Stem Cell Exhaustion	Parametric response mapping as an indicator of bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation.	24954547
Bone Diseases, Multiple Myeloma, Spinal Fractures	Stem Cell Exhaustion	In this study, we evaluated four SNPs rs11099592, rs4364254, rs4693608 and rs6535455 in the HSPE gene in 348 newly diagnosed multiple myeloma patients with focus on bone morbidity (lytic bone disease and vertebral fractures) and outcome after high-dose chemotherapy with stem cell support (HDT).	24954766
Fracture	Stem Cell Exhaustion	Bone marrow stem cells added to a hydroxyapatite scaffold result in better outcomes after surgical treatment of intertrochanteric hip fractures.	24955356
Fracture	Stem Cell Exhaustion	The authors hypothesized that adding an autologous bone marrow stem cells concentrate (ABMC) to a hydroxyapatite scaffold and placing it in the fracture site would improve the outcome after surgical fixation of intertrochanteric hip fractures.	24955356
Multiple Myeloma	Stem Cell Exhaustion	There has been significant improvement in the survival of multiple myeloma patients over the past decade as a result of incorporating autologous stem cell transplantation (ASCT) and novel agents into treatment regimens.	24957143
Macrodontia of permanent maxillary central incisor	Stem Cell Exhaustion	Characterization of pulp and follicle stem cells from impacted supernumerary maxillary incisors.	24960375
Macrodontia of permanent maxillary central incisor	Stem Cell Exhaustion	The purpose of this study was to characterize dental pulp and dental follicle stem/progenitor cells (DPSCs and DFSCs) from the same impacted supernumerary maxillary incisors (ISMIs).	24960375
Primary Myelofibrosis	Stem Cell Exhaustion	MPD-RC 101 prospective study of reduced-intensity allogeneic hematopoietic stem cell transplantation in patients with myelofibrosis.	24963042
Thrombocytosis, Polycythemia Vera, Myeloproliferative disease, Primary Myelofibrosis	Stem Cell Exhaustion	From 2007 to 2011, 66 patients with primary myelofibrosis or myelofibrosis (MF) preceded by essential thrombocythemia or polycythemia vera were enrolled into a prospective phase 2 clinical trial of reduced-intensity allogeneic hematopoietic stem cell transplantation (AHSCT), Myeloproliferative Disorder Research Consortium 101 trial.	24963042
Malignant neoplasm of stomach, Neoplasms	Stem Cell Exhaustion	Stem cell-like circulating tumor cells indicate poor prognosis in gastric cancer.	24963492
Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Circulating tumor cells (CTCs), which have stem cell-like characteristics, might play a crucial role in cancer metastasis.	24963492
Malignant neoplasm of stomach	Stem Cell Exhaustion	CD44 has been identified as gastric cancer (GC) stem cell (CSC) marker.	24963492
Restenosis	Stem Cell Exhaustion	The impact of endothelial progenitor cells on restenosis after percutaneous angioplasty of hemodialysis vascular access.	24964143
Restenosis	Stem Cell Exhaustion	We prospectively investigate the relation between baseline circulating endothelial progenitor cells and the subsequent development of restenosis after angioplasty of hemodialysis vascular access.	24964143
Toxic effect	Stem Cell Exhaustion	Dimethyl sulfoxide (DMSO) is essential for the preservation of liquid nitrogen-frozen stem cells, but is associated with toxicity in the transplant recipient.	24964911
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	In this prospective noninterventional study, we describe the use of DMSO in 64 European Blood and Marrow Transplant Group centers undertaking autologous transplantation on patients with myeloma and lymphoma and analyze side effects after return of DMSO-preserved stem cells.	24964911
Multiple Myeloma	Stem Cell Exhaustion	Mesenchymal stem cell contact promotes CCN1 splicing and transcription in myeloma cells.	24965524
Multiple Myeloma	Stem Cell Exhaustion	To elucidate the role of CCN1 in the crosstalk between stromal cells and myeloma cells, we performed co-culture experiments with primary mesenchymal stem cells (MSC) and the interleukin-6 (IL-6)-dependent myeloma cell line INA-6.	24965524
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	Even in the tyrosine kinase inhibitor era, allogeneic hematopoietic stem cell transplantation (HSCT) is regarded as standard care for adult Philadelphia (Ph) positive acute lymphoblastic leukemia (ALL).	24965535
Amyotrophic Lateral Sclerosis	Stem Cell Exhaustion	Biological markers of mesenchymal stromal cells as predictors of response to autologous stem cell transplantation in patients with amyotrophic lateral sclerosis: an investigator-initiated trial and in vivo study.	24966156
Degenerative polyarthritis	Stem Cell Exhaustion	In summary, DCC is up-regulated in CD166-positive chondrogenic progenitor cells in OA and induces down-regulation of CREB.	24966904
Cartilage damage	Stem Cell Exhaustion	These findings indicate that migration of CD166 positive progenitor cells to sites of cartilage damage may be directed by regulation of DCC signaling.	24966904
Cervical Squamous Cell Carcinoma	Stem Cell Exhaustion	Embryonic stem cell markers Sox-2 and OCT4 expression and their correlation with WNT signal pathway in cervical squamous cell carcinoma.	24966958
Malignant Neoplasms	Stem Cell Exhaustion	Both the expression of embryonic stem cells (ESCs) markers (Sox2, Oct4) and the Wnt signal pathway (b-catenin) are crucial for progression of various human malignancies.	24966958
Corneal Endothelial Cell Loss	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPCs) play an important role in post-injury regeneration of vasculature, whereas endothelial cells (ECs) reflect endothelial damage.	24968203
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Cardiomyogenic differentiation potential of human endothelial progenitor cells isolated from patients with myocardial infarction.	24969968
Myocardial Ischemia, Peripheral Arterial Diseases	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) are known to play a beneficial role by promoting postnatal vasculogenesis in pathological events, such as ischemic heart disease and peripheral artery disease.	24969968
Pheochromocytoma	Stem Cell Exhaustion	Dissecting the origin of inducible brown fat in adult humans through a novel adipose stem cell model from adipose tissue surrounding pheochromocytoma.	24971662
Clostridium difficile colitis	Stem Cell Exhaustion	Clostridium difficile infection after allogeneic hematopoietic stem cell transplant: strain diversity and outcomes associated with NAP1/027.	24973628
Clostridium difficile colitis, Central Diabetes Insipidus	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HSCT) recipients are at high risk for developing Clostridium difficile infection (CDI).	24973628
Central Diabetes Insipidus, Communicable Diseases	Stem Cell Exhaustion	Early CDI was defined as infection occurring from day -10 to day +40 from stem cell infusion.	24973628
Neoplasms	Stem Cell Exhaustion	Reactive oxygen species in normal and tumor stem cells.	24974178
Neoplasms	Stem Cell Exhaustion	In addition, the implications of the aberrant production of ROS by tumor stem cells for tumor progression and treatment are also discussed.	24974178
Neoplasms, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	AML cells from putative leukaemia stem cell subsets, including CD34+38- and CD34+38+ fractions, were equivalently affected by dual PIM/Akt inhibition when compared with bulk tumour cells.	24975213
Acute myocardial infarction	Stem Cell Exhaustion	The beneficial effects of intracoronary autologous bone marrow stem cell transfer as an adjunct to percutaneous coronary intervention in patients with acute myocardial infarction.	24975729
Acute myocardial infarction	Stem Cell Exhaustion	The efficacy of post-percutaneous coronary intervention (PCI) intracoronary injection with bone marrow mesenchymal stem cells (BMSCs) in patients with acute myocardial infarction (AMI) remains controversial.	24975729
Peripheral Stem Cell Transplantation, Specialty Type - cancer	Stem Cell Exhaustion	The aim of this study was to assess the agreement between detected changes in body composition determined by bioimpedance spectroscopy (BIS) and air-displacement plethysmography (ADP) among patients with cancer undergoing peripheral blood stem cell transplantation (PBSCT); and to assess the agreement of absolute values of BIS with ADP and dual energy x-ray (DXA).	24976421
Autoimmune cytopenia	Stem Cell Exhaustion	Autoimmune cytopenias (AC) after allogeneic hematopoietic stem cell transplantation (HSCT) are associated with a dismal prognosis.	24976527
Embryonal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	MyD88 expression was down-regulated in differentiated embryonal carcinoma (NTera2) cells, supporting the MyD88+ cancer stem cell hypothesis.	24977712
Malignant neoplasm of ovary	Stem Cell Exhaustion	Ex vivo manipulation of ovarian cancer stem cell (CSC) differentiation can decrease MyD88 expression, providing a potentially valuable CSC model for ovarian cancer.	24977712
melanoma, Stem Cell Factor	Stem Cell Exhaustion	Comparing the sera of pretreated patients against the control samples, the cytokines fibroblast growth factor 10 (FGF-10/keratinocyte growth factor-2 (KGF-2), chemokine (C-X-C motif) ligand 11 interferon inducible T cell alpha chemokine (I-TAC)/chemokine [C-X-C motif] ligand 11 (CXCL11), oncostatin M (OSM), osteoactivin/glycoprotein nonmetastatic melanoma protein B, and stem cell factor (SCF) were found significantly overexpressed.	24979617
Graft-vs-Host Disease	Stem Cell Exhaustion	Acute graft-versus-host-disease (aGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (HSCT).	24979731
Graft-vs-Host Disease	Stem Cell Exhaustion	Chronic graft versus host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation, which contributes to the morbidity and mortality of transplant patients.	24980629
Polymyositis, Traumatic AND/OR non-traumatic injury, Skeletal muscle structure, Chronic graft-versus-host disease	Stem Cell Exhaustion	A polymyositis pattern of injury is a rare manifestation of chronic GVHD in skeletal muscle after hematopoietic stem cell transplantation.	24980629
Cholangiocarcinoma	Stem Cell Exhaustion	Successfully-treated advanced bile duct cancer of donor origin after hematopoietic stem cell transplantation by pancreaticoduodenectomy: a case report.	24982403
Neoplasm Metastasis	Stem Cell Exhaustion	Secondary malignancies are one of the late complications observed in long-term survivors of allogeneic hematopoietic stem cell transplantation (HSCT).	24982403
Lymphoma	Stem Cell Exhaustion	Considering this residuum and the aggressive subtype of lymphoma he was referred for an autologous hemopoietic stem cell transplantation (AHSCT).	24985032
Urinary Stress Incontinence	Stem Cell Exhaustion	Autologous adipose stem cells in treatment of female stress urinary incontinence: results of a pilot study.	24985079
Sui Chinese, Urinary Stress Incontinence	Stem Cell Exhaustion	The purpose of our study was to find out whether transurethral injections of autologous adipose stem cells (ASCs) are an effective and a safe treatment for female stress urinary incontinence (SUI).	24985079
B-Cell Lymphomas, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	To assess the efficacy of dose-intensive immunochemotherapy with or without autologous hematopoietic stem cell transplantation (ASCT) for newly diagnosed young patients with medium/high risk diffuse large B-cell lymphoma (DLBCL).	24985182
Toxic effect	Stem Cell Exhaustion	In hematopoietic stem cell transplantation (HSCT), patients receive individualized treatment planning in conditioning regimens to prevent unwarranted toxicities while maximizing desired outcomes.	24986792
Prostate carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Expression of androgen and estrogen signaling components and stem cell markers to predict cancer progression and cancer-specific survival in patients with metastatic prostate cancer.	24987058
Prostate carcinoma	Stem Cell Exhaustion	Genes of androgen and estrogen signaling cells and stem cell-like cells play crucial roles in prostate cancer.	24987058
Acute leukemia	Stem Cell Exhaustion	Liposomal daunorubicin, fludarabine, and cytarabine (FLAD) as bridge therapy to stem cell transplant in relapsed and refractory acute leukemia.	24989345
Acute leukemia	Stem Cell Exhaustion	We report the outcome of 79 patients with relapsed-refractory acute leukemia treated with fludarabine, cytarabine, and liposomal daunorubicin (FLAD regimen) followed by hematopoietic stem cell transplantation (HSCT), when clinically indicated, between May 2000 and January 2013.	24989345
Rheumatoid Arthritis	Stem Cell Exhaustion	To identify factors influencing endothelial progenitor cell (EPC) counts in patients with rheumatoid arthritis (RA).	24991663
Rheumatoid Arthritis, Endothelial dysfunction	Stem Cell Exhaustion	Bone erosion is associated with reduction of circulating endothelial progenitor cells and endothelial dysfunction in rheumatoid arthritis.	24991663
Rubella, Mumps	Stem Cell Exhaustion	Evaluation of the immune status against measles, mumps, and rubella in adult allogeneic hematopoietic stem cell transplantation recipients.	24992512
Mumps	Stem Cell Exhaustion	Previous studies have shown that most patients lose immunity to measles, mumps, and rubella (MMR) during long-term follow-up after allogeneic hematopoietic stem cell transplantation (HSCT), and immunizations against them have been investigated.	24992512
Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE	Stem Cell Exhaustion	Effect of aliskiren on circulating endothelial progenitor cells and vascular function in patients with type 2 diabetes and essential hypertension.	24994608
Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE	Stem Cell Exhaustion	The aim of this study was to investigate the effects of aliskiren on vascular function and endothelial progenitor cells (EPCs) in patients with type 2 diabetes and essential hypertension.	24994608
Hematologic Neoplasms, Transfusion hemosiderosis	Stem Cell Exhaustion	This is the first prospective study of deferasirox in adult allogeneic hematopoietic stem cell transplant recipients with transfusional iron overload in hematologic malignancies.	24997153
Gastrointestinal Stromal Tumors	Stem Cell Exhaustion	Gastric gastrointestinal stromal tumors (GISTs) usually contain the mast/stem cell growth factor receptor Kit gene (KIT) or platelet-derived growth factor receptor A (PDGFRA) mutations that can be targeted by, or mediate resistance to, imatinib.	24997326
Aortic Aneurysm, Abdominal	Stem Cell Exhaustion	Proinflammatory role of stem cells in abdominal aortic aneurysms.	24997808
Aneurysmal	Stem Cell Exhaustion	We sought to describe the presence of stem cells in human AAA tissue and also investigated the differentiation of stem cells within the aneurysmal aorta.	24997808
Aneurysm	Stem Cell Exhaustion	These finding suggest an inflammatory/immune role of stem cells during AAA pathogenesis and raise the possibility of localized replenishment therapy within the aneurysm wall.	24997808
Dyskeratosis Congenita, Hemorrhagic colitis	Stem Cell Exhaustion	Diffuse hemorrhagic colitis in a patient with dyskeratosis congenita after nonmyeloablative allogeneic hematopoietic stem cell transplantation.	25000468
Bone marrow hypocellularity	Stem Cell Exhaustion	Bone marrow failure in DC can only be cured by allogeneic hematopoietic stem cell transplantation (HSCT).	25000468
nervous system disorder	Stem Cell Exhaustion	Over the last decade, human cell transplantation and neural stem cell trials have examined the feasibility and safety of these potential therapies for treatment of a variety of neurological disorders.	25002238
Vasculitis, CTCAE, Autoimmune Diseases	Stem Cell Exhaustion	ANCA-positive vasculitis as a secondary autoimmune disease after autologous stem cell transplantation for systemic sclerosis: a case report.	25005330
Autoimmune Diseases, Systemic Scleroderma, Up, Sample Size Calculation	Stem Cell Exhaustion	Autologous stem cell transplantation (SCT) is increasingly used to treat autoimmune diseases (AD), in particular systemic sclerosis (SSc).	25005330
Autoimmune Diseases	Stem Cell Exhaustion	Secondary autoimmune diseases are a known complication after autologous stem cell transplantations for any cause.	25005330
Vasculitis, CTCAE, Autoimmune Diseases	Stem Cell Exhaustion	We provide the first report of a patient who developed a p-ANCA-associated vasculitis after autologous stem cell transplantation for an autoimmune disease, namely systemic sclerosis.	25005330
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	CTC presence was evaluated with real-time reverse transcription polymerase chain reaction assay (qPCR) based on the expression of three tumor genetic markers: carcinoembryonic antigen (CEA), cytokeratin 20 (CK20), and/or cancer stem cells marker CD133 (CEA/CK20/CD133).	25006584
Senile cardiac amyloidosis	Stem Cell Exhaustion	Median OPN plasma level were associated with number of organs involved, renal function, eligibility for high-dose melphalan chemotherapy and autologous stem cell transplantation, and severity of cardiac amyloidosis.	25007036
Communicable Diseases	Stem Cell Exhaustion	[Usefulness of wide-range microbiological diagnostics proceedings in case of simultaneous infection with four herpesviruses after allogeneic haematopoietic stem cell transplantation--a case report].	25007510
Immunocompromised Host	Stem Cell Exhaustion	A case of fatal post-transplant reactivation with four herpesviruses in 49-year-old immunocompromised male with MDS-RAEB2, subjected to allogeneic haematopoietic stem cell transplantation was described.	25007510
leukemia	Stem Cell Exhaustion	Leukemia is a type of malignant hematopoietic tumor in hematopoietic stem cells.	25011265
Prostate carcinoma, Ionizing radiation	Stem Cell Exhaustion	In this study, exposure of four metastasis-derived human prostate cancer cell lines (DU145, PC-3, LNCaP and 22RV1) to clinically relevant daily fractions of ionizing radiation (35 doses of 2 Gy) resulted in generation of two radiation-surviving populations: adherent senescent-like cells expressing common senescence-associated markers and non-adherent anoikis-resistant stem cell-like cells with active Notch signaling and expression of stem cell markers CD133, Oct-4, Sox2 and Nanog.	25012501
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	In contrast to TKIs, interferon (IFN) is directly toxic to CML progenitor cells, and myeloid growth factors such as GM-CSF may enhance IFN's cytotoxicity.	25012565
Hemopoietic stem cell transplant	Stem Cell Exhaustion	From March 2010 to September 2010, all patients admitted to our unit for chemotherapy for acute leukemia or hematopoietic stem cell transplantation received optimized PSZ prophylaxis 200 mg four times daily with cola soda.	25012993
Specialty Type - cancer, Nasopharyngeal carcinoma	Stem Cell Exhaustion	E3-ligase Skp2 predicts poor prognosis and maintains cancer stem cell pool in nasopharyngeal carcinoma.	25015320
Specialty Type - cancer	Stem Cell Exhaustion	Our study not only interprets the predictive role of Skp2 in the poor prognosis of NPC patients, but also reveals that Skp2 regulates the NPC cancer stem cell maintenance, which shed lights on the target therapy and early diagnosis of NPC in clinical application.	25015320
Neoplasms, Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	Moreover, the presence in these tumors of cancer stem cells, which are characterized by CD133 expression, has been associated with chemoresistance, radioresistance, metastasis, and local recurrence.	25015560
Allogeneic Hematopoietic Stem Cell Transplantation, Central Nervous System, Acute lymphocytic leukemia	Stem Cell Exhaustion	Central nervous system relapse in adults with acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation.	25017763
Acute lymphocytic leukemia, Central Nervous System, BCR gene	Stem Cell Exhaustion	Central nervous system (CNS) relapse after allogeneic hematopoietic stem cell transplantation (HSCT) confers a poor prognosis in adult patients with acute lymphoblastic leukemia (ALL).	25017763
Graft-vs-Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic graft-versus-host disease (GVHD) induces significant morbidity and mortality after allogeneic hematopoietic stem cell transplantation.	25017765
Aneuploidy	Stem Cell Exhaustion	Asymmetric aneuploidy in mesenchymal stromal cells detected by in situ karyotyping and fluorescence in situ hybridization: suggestions for reference values for stem cells.	25019198
Childhood Breast Carcinoma	Stem Cell Exhaustion	Cytogenetic analysis was performed on 103 consecutive cultures from 68 MSCs (25 adipose-origin, 20 bone marrow-origin, 18 cord blood-origin, and 5 neural stem cells; 8 from adipose tissue of patients with breast cancer and 60 from healthy donors).	25019198
Intestinal Neuroendocrine Tumor	Stem Cell Exhaustion	An integrated cellular transcriptomic analysis of small intestinal neuroendocrine tumors identified that they are regulated at a developmental level, have key activation of hypoxic pathways (a known regulator of malignant stem cell phenotypes) as well as activation of genes involved in apoptosis and proliferation.	25023465
Specialty Type - cancer, Infection	Stem Cell Exhaustion	We evaluated the effect of cancer type, age, gender, genetic syndrome, stem cell transplantation, PRISM3 score, infections, and critical care interventions on PICU mortality.	25023526
Specialty Type - cancer, Leukemia, Myelocytic, Acute, Communicable Diseases	Stem Cell Exhaustion	Among hematologic cancer patients, stem cell transplantation, diagnosis of acute myeloid leukemia, PRISM3 score, and infection were all independently associated with PICU mortality.	25023526
Up, "Alzheimers Disease	Stem Cell Exhaustion	But their roles in the neural stem cells (NSCs), including glial precursor cells (GPCs), of Alzheimer's disease (AD) are unclear.	25027328
Cardiovascular Diseases	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPCs) reflect endothelial repair capacity and may be a significant marker for the clinical outcomes of cardiovascular disease.	25027585
Hematologic Neoplasms	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplant for hematological malignancies from mismatched 9/10 human leukocyte antigen unrelated donors: comparison with transplants from 10/10 unrelated donors and human leukocyte antigen identical siblings.	25029640
Histogenic Process, Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Although its histogenesis and biological aspects remain poorly understood, previous studies have postulated that this tumor may arise from single cancer stem cells which subsequently differentiate into distinct tumor lineages.	25031014
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Recent evidence suggested that tumor initiation and growth are driven by a subset of tumor-initiating cells termed cancer stem cells.	25034654
Neoplasms	Stem Cell Exhaustion	Nestin has been widely used as a marker for melanocyte stem cells as well as an angiogenic marker to evaluate neovascularity of endothelial cells in tumors.	25034654
Cutaneous Melanoma, melanoma	Stem Cell Exhaustion	To gain an insight into the impact of Notch1 activation on the maintenance of melanocyte stem cells and angiogenesis in melanoma, the expression levels of activated Notch1 and nestin were analyzed by immunohistochemistry in 114 primary cutaneous melanomas and 35 lymph node metastases.	25034654
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Donor lymphocyte infusion for the treatment of relapsed acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation: a retrospective analysis by the Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation.	25034960
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Because the efficacy of donor lymphocyte infusion (DLI) for acute myeloid leukemia (AML) relapse after allogeneic hematopoietic stem cell transplantation (HSCT) remains uncertain, especially in the Asian population, a nationwide registry study was retrospectively performed by the Adult AML Working Group of the Japan Society for Hematopoietic Cell Transplantation to identify the factors affecting the patient survival after DLI.	25034960
Neoplasms	Stem Cell Exhaustion	Notch pathway molecules crosstalk with Wnt/b-catenin signaling cascade in stem cells and tumors.	25037575
Fibrosis Assessment	Stem Cell Exhaustion	Mesenchymal stromal cells (MSC), a key component of the stem cell niche in bone marrow and possibly other organs including lung, have been shown to enhance epithelial repair and are effective in preclinical models of inflammation-induced pulmonary fibrosis, but may be profibrotic in some circumstances.	25039426
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Relapsed aggressive lymphomas are often treated with platinum-based chemotherapy (PBC) followed by an autologous stem cell transplant (ASCT).	25039868
Malignant Neoplasms	Stem Cell Exhaustion	To compare the cumulative incidence (CI), severity and mortality of IM in eras immediately before and after the commercial availability of voriconazole all IM cases from 1995 to 2011 were analysed across four risk-groups (hematologic/oncologic malignancy (H/O), stem cell transplantation (SCT), solid organ transplantation (SOT) and other), and two eras, E1 (1995-2003) and E2, (2004-2011).	25040241
Hemorrhagic cystitis	Stem Cell Exhaustion	BK virus-associated hemorrhagic cystitis (BKV-HC) is a common and major cause of morbidity in recipients of allogeneic hematopoietic stem cell transplantation.	25040402
Clostridium difficile colitis	Stem Cell Exhaustion	Risk factors for recurrent Clostridium difficile infection in hematopoietic stem cell transplant recipients.	25040545
Clostridium difficile colitis, Central Diabetes Insipidus	Stem Cell Exhaustion	Recurrent Clostridium difficile infection (CDI) represents a significant burden on the healthcare system and is associated with poor outcomes in hematopoietic stem cell transplant (HSCT) patients.	25040545
Pneumococcal Infections	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (alloHSCT) recipients are at high risk of invasive pneumococcal disease (IPD).	25040633
Hyperpigmentation, Lentigo	Stem Cell Exhaustion	It has been reported that the abnormal regulation of melanocyte stem cells (McSCs) causes hair greying; however, little is known about the role of McSCs in skin hyperpigmentation such as solar lentigines (SLs).	25040700
Lymphoma, Follicular	Stem Cell Exhaustion	The role of allogeneic (allo-) and autologous stem cell transplantation (auto-SCT) in the management of patients with transformed indolent nonfollicular non-Hodgkin lymphoma is unknown.	25042735
Lymphoma, Follicular	Stem Cell Exhaustion	Adjusted for type of stem cell transplantation, 3-year overall survival, progression-free survival, and nonrelapse mortality rates were similar to those of patients with transformed follicular lymphoma receiving allo-SCT and auto-SCT (P = .38, P = .69, and P = .54, respectively).	25042735
B-Cell Lymphomas, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Infused autograft absolute lymphocyte count is a prognostic factor for survival after autologous peripheral hematopoietic stem cell transplantation (APHSCT) for diffuse large B cell lymphoma (DLBCL).	25042737
Malignant neoplasm of breast	Stem Cell Exhaustion	To determine if EZH2 is required to establish H3K27me3 marks in mammary cancer, Brca1 and Ezh2 were deleted in mammary stem cells in mice.	25043748
Juvenile Myelomonocytic Leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Clinical course of juvenile myelomonocytic leukemia in the blast crisis phase treated by acute myeloid leukemia-oriented chemotherapy and allogeneic hematopoietic stem cell transplantation.	25047104
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Although he had several poor prognostic factors, including monosomy 7 and high HbF percentage, he achieved partial remission after treatment with acute myeloid leukemia-oriented chemotherapy followed by allogeneic hematopoietic stem cell transplantation.	25047104
Multiple Myeloma	Stem Cell Exhaustion	In Taiwan, melphalan and several novel agents are used to treat myeloma patients who are not candidate for hematopoietic stem cell transplant (HSCT).	25047657
Coronary Arteriosclerosis	Stem Cell Exhaustion	Endothelial progenitor stem cells (EPCs) are mobilized to the peripheral circulation in response to myocardial ischemia, playing a crucial role in vascular repair.	25048407
Acute myocardial infarction	Stem Cell Exhaustion	Impact of prior chronic statin therapy and high-intensity statin therapy at discharge on circulating endothelial progenitor cell levels in patients with acute myocardial infarction: a prospective observational study.	25048407
PAFAH1B1 wt Allele, Neoplasms, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is a stem cell tumor characterized by dysplastic features and ineffective hematopoiesis in the early phase and leukemic progression in the late phase.	25056847
Anemia, Sickle Cell	Stem Cell Exhaustion	Nonmyeloablative HLA-matched sibling allogeneic hematopoietic stem cell transplantation for severe sickle cell phenotype.	25058217
Anemia, Sickle Cell, Toxic effect	Stem Cell Exhaustion	Myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) is curative for children with severe sickle cell disease, but toxicity may be prohibitive for adults.	25058217
Amyloidosis	Stem Cell Exhaustion	Oral melphalan and dexamethasone (MDex) is a standard treatment for patients with AL amyloidosis who are not eligible for stem cell transplantation at many referral centers.	25059496
Carcinogenesis	Stem Cell Exhaustion	Using an LSD1 inhibitor, CBB1003, as a probe, we studied the association between LSD1 and leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), a CRC stem cell marker involved in carcinogenesis.	25060070
Coronary Arteriosclerosis	Stem Cell Exhaustion	Variation at the CXCL12 locus is associated with coronary artery disease and endothelial progenitor cell numbers, whereas variation at the CXCR4 locus is associated with leukocyte telomere length, which has been shown to be associated with coronary artery disease.	25060794
Cardiovascular Diseases	Stem Cell Exhaustion	Therefore, we examined the relationships of plasma SDF-1 levels to cardiovascular disease (CVD)-related outcomes, risk factors, leukocyte telomere length, and endothelial progenitor cells.	25060794
Neutropenia, Malignant Neoplasms	Stem Cell Exhaustion	We compared the microbiological findings with respect to neutropenia, hematopoietic stem cell transplantation (HSCT) status, and the type of malignancy.	25062720
Leukemia, Myelomonocytic, Chronic, Hematological Disease	Stem Cell Exhaustion	Chronic myelomonocytic leukemia (CMML) is a clonal disorder of hematopoietic stem cells often occurring in elderly patients.	25063763
Thalassemia	Stem Cell Exhaustion	Outcomes of thalassemia patients undergoing hematopoietic stem cell transplantation by using a standard myeloablative versus a novel reduced-toxicity conditioning regimen according to a new risk stratification.	25064743
Thalassemia	Stem Cell Exhaustion	Improving outcomes among class 3 thalassemia patients receiving allogeneic hematopoietic stem cell transplantations (HSCT) remains a challenge.	25064743
Graft-vs-Host Disease	Stem Cell Exhaustion	Calcineurin inhibitor--free graft-versus-host disease prophylaxis with post-transplantation cyclophosphamide and brief-course sirolimus following reduced-intensity peripheral blood stem cell transplantation.	25064745
Acute GVH disease	Stem Cell Exhaustion	Synergistic effect of major histocompatibility complex class I-related chain a and human leukocyte antigen-DPB1 mismatches in association with acute graft-versus-host disease after unrelated donor hematopoietic stem cell transplantation.	25064744
Electrocardiogram: myocardial infarction (finding), diabetic	Stem Cell Exhaustion	Endothelial progenitor cells in diabetic patients with myocardial infarction - can statins improve their function?	25066111
diabetic, Acute myocardial infarction	Stem Cell Exhaustion	The effect of statins on endothelial progenitor cells (EPCs) function derived from diabetic patients (DMpts) with acute myocardial infarction (AMI) is unknown.	25066111
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	The hematopoietic stem cell transplant comorbidity index can predict for 30-day readmission following autologous stem cell transplant for lymphoma and multiple myeloma.	25068419
Hematologic Neoplasms	Stem Cell Exhaustion	Patients who undergo autologous stem cell transplant (ASCT) for hematologic malignancies frequently have multiple comorbidities.	25068419
Venoocclusive disease	Stem Cell Exhaustion	Incidence and risk factors for moderate-to-severe veno-occlusive disease of the liver after allogeneic stem cell transplantation using a reduced intensity conditioning regimen.	25068424
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Indeed, longevity of AML characteristics, as well as sufficient stem cells in the xenograft model, should be guaranteed to analyze the therapeutic response to a drug.	25069538
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Therefore, we examined whether leukapheresed peripheral blood (LPB) consists of reliable leukemic stem cells (LSCs) and ALDHdim-expressing CD34+CD38- cells, and functions in grafting human AML with virulence compared to that of BM.	25069538
Neoplasms	Stem Cell Exhaustion	These results suggest that UPS tumors share a similar lineage as leiomyosarcomas and are likely to originate from different stages of differentiation from mesenchymal stem cells to smooth muscle cells.	25069693
Agenesis	Stem Cell Exhaustion	Thus, Human herpesvirus 6 reactivation during aplasia, lower unit-unit human leukocyte antigen matching, and younger UCB unit age, as new unfavorable predictive factors, may represent new parameters to take into account after double UCB allogeneic stem-cell transplantation in adults.	25072620
B-Cell Lymphomas	Stem Cell Exhaustion	Upfront consolidation combining yttrium-90 ibritumomab tiuxetan and high-dose therapy with stem cell transplantation in poor-risk patients with diffuse large B cell lymphoma.	25072780
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Seventy-five high-risk (>=2 International Prognostic Index [IPI] factors) consecutive DLBCL patients (<=65 years old) in complete remission (CR) or partial remission (PR) after rituximab chemotherapy were treated with Y(90) ibritumomab tiuxetan and BEAM regimen followed by autologous stem cell transplantation (ASCT).	25072780
Lymphoma	Stem Cell Exhaustion	Among 60 lymphoma patients who had less than 30 CD34 cells/mm(3) the day before the first apheresis, an increase in the CD34 cell count between Day -1 and Day 1 was predictive of first stem cell mobilisation success, with a sensitivity of 100% if the Day 1 was higher than 30/mm(3) (10/60 patients).	25073661
Blindness	Stem Cell Exhaustion	Autologous cultivated limbal epithelial transplantation (CLET) is a successful therapy to restore corneal epithelium when limbal epithelial stem cells are damaged unilaterally, which can result in corneal blindness.	25075515
Cessation of life, Diarrhea, Clostridium difficile	Stem Cell Exhaustion	Incidence of diarrhea by Clostridium difficile in hematologic patients and hematopoietic stem cell transplantation patients: risk factors for severe forms and death.	25076434
Neutropenia, Cessation of life	Stem Cell Exhaustion	We describe the rate of incidence of Clostridium difficile-associated diarrhea (CDAD) in hematologic and patients undergone stem cell transplant (HSCT) at HC-FMUSP, from January 2007 to June 2011, using two denominators 1,000 patient and 1,000 days of neutropenia and the risk factors associated with the severe form of the disease and death.	25076434
Bare Lymphocyte Syndrome	Stem Cell Exhaustion	Passenger lymphocyte syndrome is a complication of both solid-organ and stem cell transplants.	25077954
Lesion	Stem Cell Exhaustion	Runx1 becomes highly expressed at the periphery of mouse OA lesions and in human OA chondrocyte 'clones' where Runx1 co-localizes with Vcam1, the mesenchymal stem cell (MSC) marker and lubricin (Prg4), a cartilage chondroprotective protein.	25078095
Multiple Myeloma	Stem Cell Exhaustion	Functional autoantibodies against SSX-2 and NY-ESO-1 in multiple myeloma patients after allogeneic stem cell transplantation.	25078248
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Cytopenia	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders characterized by peripheral cytopenias and ineffective hematopoiesis.	25079655
Antilymphocyte Serum	Stem Cell Exhaustion	We observed the same phenomenon in freshly isolated PBMC from ALS patients (reduced 24-35%, ANOVA p < 0.001) and reproduced it in a human neural stem cell model treated with 2',3'-dideoxycytidine (ddC) (reduced 52-78%, ANOVA p < 0.001).	25081190
Specialty Type - cancer, Pancreatic carcinoma	Stem Cell Exhaustion	The IL-8/CXCR1 axis is associated with cancer stem cell-like properties and correlates with clinical prognosis in human pancreatic cancer cases.	25081383
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	CXCR1, a receptor for CXCL8/IL-8, has recently been demonstrated to be associated with cancer stem cell (CSC) populations in certain types of human cancers.	25081383
Communicable Diseases	Stem Cell Exhaustion	Impact of pretransplant serum ferritin level on risk of invasive mold infection after allogeneic hematopoietic stem cell transplantation.	25082161
Infection	Stem Cell Exhaustion	Invasive mold infections (IMI) are life-threatening complications of allogeneic hematopoietic stem cell transplantation (HSCT) and are mostly caused by Aspergillus species and Mucorales.	25082161
Congestive heart failure	Stem Cell Exhaustion	The objective of this study was to assess a relationship between insulin resistance (IR) and counts of CD45(-)CD34(+), CD14(+)CD309(+), and CD14(+)CD309(+)Tie2(+) phenotyped circulating endothelial progenitor cells (EPCs) in patients with ischemic chronic heart failure (CHF).	25082501
JAK2 NP_004963.1:p.V617F, Polycythemia Vera	Stem Cell Exhaustion	Hematopoietic clonal dominance, stem cell mutations, and evolutionary pattern of JAK2V617F allele burden in polycythemia vera.	25082530
JAK2 NP_004963.1:p.V617F, Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase	Stem Cell Exhaustion	JAK2V617F was measured in stem cells, progenitor cells, and granulocytes of 45 patients with PV (early chronic phase n = 26, late chronic phase n = 10, post-PV MF n = 9).	25082530
Neutropenia, Trichosporon asahii, Infection of bloodstream, Pichia kudriavzevii	Stem Cell Exhaustion	There were two bloodstream infections caused by yeasts or yeast-like fungi (Candida krusei, Trichosporon asahii) in two patients during the neutropenic phase after allogeneic haematopoietic stem cell transplantation.	25082655
Gastrointestinal mucositis	Stem Cell Exhaustion	Miconazole mucoadhesive buccal tablet in high-dose therapy with autologous stem cell transplantation (HDT/ASCT)-induced mucositis.	25084742
Gastrointestinal mucositis, Communicable Diseases	Stem Cell Exhaustion	Oral mucositis is a major cause of morbidity in high-dose therapy/autologous stem cell transplantation (HDT/ASCT), where microbial colonization has an important pathological implication.	25084742
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Effect of graft sources on allogeneic hematopoietic stem cell transplantation outcome in adults with chronic myeloid leukemia in the era of tyrosine kinase inhibitors: a Japanese Society of Hematopoietic Cell Transplantation retrospective analysis.	25085253
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We retrospectively compared transplant outcomes for related bone marrow transplantation (rBMT), related peripheral blood stem cell transplantation (rPBSCT), unrelated bone marrow transplantation (uBMT), and unrelated cord blood transplantation (CBT) in 1,062 patients with chronic myeloid leukemia (CML) aged 20 years or over between January 1, 2000 and December 31, 2009 in Japan.	25085253
Myeloid neoplasm	Stem Cell Exhaustion	Reduced-toxicity conditioning prior to allogeneic stem cell transplantation improves outcome in patients with myeloid malignancies.	25085356
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Impact of the International Prognostic Scoring System cytogenetic risk groups on the outcome of patients with primary myelodysplastic syndromes undergoing allogeneic stem cell transplantation from human leukocyte antigen-identical siblings: a retrospective analysis of the European Society for Blood and Marrow Transplantation-Chronic Malignancies Working Party.	25085359
MYELODYSPLASTIC SYNDROME, Chromosome Aberrations	Stem Cell Exhaustion	Acquired chromosomal abnormalities are important prognostic factors in patients with myelodysplastic syndromes treated with supportive care and with disease-modifying therapeutic interventions, including allogeneic hematopoietic stem cell transplantation.	25085359
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	To assess the prognostic impact of cytogenetic characteristics after hematopoietic stem cell transplantation accurately, we investigated a homogeneous group of 523 patients with primary myelodysplastic syndromes who have received stem cells from human leukocyte antigen-identical siblings.	25085359
Anemia, Sideroblast, MYELODYSPLASTIC SYNDROME, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	In conclusion, this study shows that, in a large series of patients with primary myelodysplastic syndromes, poor-risk cytogenetics as defined by the standard International Prognostic Scoring System is associated with a relatively poor survival after allogeneic stem cell transplantation from human leukocyte antigen-identical siblings except in patients who are transplanted in refractory anemia/refractory anemia with ringed sideroblasts stage before progression to higher myelodysplastic syndrome stages.	25085359
Childhood Breast Carcinoma, Neoplasms	Stem Cell Exhaustion	MicroRNA-9 is associated with epithelial-mesenchymal transition, breast cancer stem cell phenotype, and tumor progression in breast cancer.	25086633
Childhood Breast Carcinoma	Stem Cell Exhaustion	Some miRNAs, especially the miR-200 family, miR-9, and miR-155 have been reported to be associated with epithelial-mesenchymal transition (EMT) and breast cancer stem cell (BCSC) phenotypes.	25086633
Specialty Type - cancer, Adult Glioblastoma, Neoplasms	Stem Cell Exhaustion	Primary cell lines derived as neurospheres, enriched in cancer stem cells, are currently the focus of interest in glioblastoma to test new drugs, because of their tumor initiating abilities and resistance to conventional therapies.	25088051
Adult Glioblastoma, Specialty Type - cancer	Stem Cell Exhaustion	Primary cell lines enriched in cancer stem cells (CSC) have become popular models for testing new drugs for glioblastoma.	25088051
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are a diverse group of clonal hematopoietic stem cell malignancies that primarily affect the elderly.	25088696
Hypertrophy, Degenerative polyarthritis	Stem Cell Exhaustion	Several studies have shown that type X collagen (COL X), a marker of late-stage chondrocyte hypertrophy, is expressed in mesenchymal stem cells (MSCs) from osteoarthritis (OA) patients.	25091567
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Somatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation.	25092778
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Whether these types of mutations predict outcome after allogeneic hematopoietic stem-cell transplantation (HSCT) in patients with MDS is not known.	25092778
Hodgkin Disease	Stem Cell Exhaustion	Donor lymphocyte infusion is an effective therapy for relapsed Hodgkin lymphoma after reduced-intensity allogeneic hematopoietic stem cell transplantation.	25096222
Specialty Type - cancer	Stem Cell Exhaustion	We recently reported that low dose long-term fractionated radiation concentrates cancer stem cells (CSCs).	25098609
Thrombosis	Stem Cell Exhaustion	In animals, acrolein exposure is associated with the suppression of circulating progenitor cells and increases in thrombosis and atherogenesis.	25099132
Antilymphocyte Serum	Stem Cell Exhaustion	Previously, we found that glia from mice carrying the SOD1G93A mutation, a model of ALS, were toxic to stem cell-derived human motor neurons.	25100738
Antilymphocyte Serum	Stem Cell Exhaustion	Our findings suggest that blocking DP1 may be a therapeutic strategy in ALS and demonstrate that discoveries from stem cell models of disease can be corroborated in vivo.	25100738
Amyotrophic Lateral Sclerosis, nervous system disorder, Antilymphocyte Serum	Stem Cell Exhaustion	Neurons produced from stem cells have emerged as a tool to identify new therapeutic targets for neurological diseases such as amyotrophic lateral sclerosis (ALS).	25100738
Periodontitis	Stem Cell Exhaustion	Circulating endothelial progenitor cells in periodontitis.	25101916
Periodontitis	Stem Cell Exhaustion	Circulating endothelial progenitor cells (cEPCs) are known to contribute to vascular repair, but limited data are available regarding the relationship between cEPC levels and periodontitis.	25101916
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The ordered acquisition of Class II and Class I mutations directs formation of human t(8;21) acute myelogenous leukemia stem cell.	25101977
leukemia	Stem Cell Exhaustion	The cellular properties of leukemia stem cells (LSCs) are achieved at least through Class I and Class II mutations that generate signals for enhanced proliferation and impaired differentiation, respectively.	25101977
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Here we show that in t(8;21) acute myelogenous leukemia (AML), hematopoietic stem cells (HSCs) transform into LSCs via definitively-ordered acquisition of Class II (AML1/ETO) and then Class I (c-KIT mutant) abnormalities.	25101977
Fracture	Stem Cell Exhaustion	Using a small animal model of long-bone fracture healing based on chronologic age, we asked how aging affected (1) the amount, density, and proportion of bone formed during healing; (2) the amount of cartilage produced and the progression to bone during healing; (3) the callus structure and timing of the fracture healing; and (4) the behavior of progenitor cells relative to the observed deficiencies of geriatric fracture healing.	25106797
Cerebrovascular accident	Stem Cell Exhaustion	Intra-Arterial Immunoselected CD34+ Stem Cells for Acute Ischemic Stroke.	25107583
Ischemic stroke, Cerebrovascular accident	Stem Cell Exhaustion	We performed a prospective, nonrandomized, open-label, phase I study of autologous, immunoselected CD34+ stem/progenitor cell therapy in patients presenting within 7 days of onset with severe anterior circulation ischemic stroke (National Institutes of Health Stroke Scale [NIHSS] score>=8).	25107583
Ischemic stroke, Infarction	Stem Cell Exhaustion	Autologous CD34+ selected stem/progenitor cell therapy delivered intra-arterially into the infarct territory can be achieved safely in patients with acute ischemic stroke.	25107583
Ischemic stroke	Stem Cell Exhaustion	Treatment with CD34+ hematopoietic stem/progenitor cells has been shown to improve functional recovery in nonhuman models of ischemic stroke via promotion of angiogenesis and neurogenesis.	25107583
Aplastic Anemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome evolving from aplastic anemia treated with immunosuppressive therapy: efficacy of hematopoietic stem cell transplantation.	25107891
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We identified 123 patients with post-aplastic anemia myelodysplastic syndrome who from 1991 through 2011 underwent allogeneic hematopoietic stem cell transplantation, and in a matched-pair analysis compared outcome to that in 393 patients with de novo myelodysplastic syndrome.	25107891
Vascular calcification	Stem Cell Exhaustion	Wnt5a is associated with the differentiation of bone marrow mesenchymal stem cells in vascular calcification by connecting with different receptors.	25109262
Amyloidosis	Stem Cell Exhaustion	Plerixafor and abbreviated-course granulocyte colony-stimulating factor for mobilizing hematopoietic progenitor cells in light chain amyloidosis.	25111581
Amyloidosis	Stem Cell Exhaustion	We analyzed hematopoietic progenitor cells (HPC) mobilization outcomes in 49 consecutive AL amyloidosis patients at our institution between 2004 and 2013 with granulocyte colony-stimulating factor (G) (10 mg/kg/day) (n = 25) versus an institutional protocol to limit G exposure using plerixafor (P) (.24 mg/kg s.c. starting day 3 of G 10 mg/kg) (n = 24).	25111581
Ovarian Insufficiency	Stem Cell Exhaustion	Ovarian insufficiency and pubertal development after hematopoietic stem cell transplantation in childhood.	25111958
Ovarian Insufficiency, Specialty Type - cancer, Non-host Organism Identifiers Domain, Infertility	Stem Cell Exhaustion	Ovarian insufficiency (OI) and infertility are common and devastating late effects of cancer treatment and hematopoietic stem cell transplantation (HSCT).	25111958
Bone necrosis	Stem Cell Exhaustion	Icariin may benefit the mesenchymal stem cells of patients with steroid-associated osteonecrosis by ABCB1-promoter demethylation: a preliminary study.	25112719
Bone necrosis	Stem Cell Exhaustion	In this study, we found out a previously undefined function of icariin which restored the dynamic balance between osteogenic and adipogenic differentiation of mesenchymal stem cells (MSCs) in patients with osteonecrosis of femoral head (ONFH) via ABCB1-promoter demethylation.	25112719
BCR gene	Stem Cell Exhaustion	Complete remission rate, remission duration, and overall survival were not significantly different according to the presence of CK or MK in the whole series, according to the B or T lineage, in the high-risk group, or in patients with t(9;22), regardless of imatinib treatment, and in patients who received chemotherapy alone or chemotherapy followed by stem cell transplantation Our study shows that CK and MK were not associated with a worse prognosis in adult patients with ALL treated with risk-adapted or subtype-oriented protocols.	25116331
Pfaundler-Hurler Syndrome	Stem Cell Exhaustion	Unrelated CD3/CD19-depleted peripheral stem cell transplantation for Hurler syndrome.	25116402
Mucopolysaccharidoses, Intrahepatic Route of Drug Administration, Pfaundler-Hurler Syndrome	Stem Cell Exhaustion	For patients with mucopolysaccharidosis type IH (MPS1-H; Hurler syndrome), early allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of choice.	25116402
Graft-vs-Host Disease, Toxic effect	Stem Cell Exhaustion	Treosulfan-based conditioning offers the advantage of reduced toxicity; the use of unrelated CD3/CD19-depleted peripheral stem cell grafts allows transfusion of high CD34+ cell numbers together with a "tailored" number of CD3+ cells as well as engraftment facilitating cells in order to achieve rapid hematopoietic engraftment while reducing the risk of graft rejection and GVHD.	25116402
Brachial Plexus Block	Stem Cell Exhaustion	On day 14, 2.8 ml stem cell inoculum was infused under local anesthesia in right brachial plexus sheath by brachial block technique under ultrasonography guidance with a 1.5-inch-long 23 gauge needle.	25116721
Coma, Post-Head Injury	Stem Cell Exhaustion	Co-infusion of autologous adipose tissue derived neuronal differentiated mesenchymal stem cells and bone marrow derived hematopoietic stem cells, a viable therapy for post-traumatic brachial plexus injury: a case report.	25116721
Multiple Myeloma	Stem Cell Exhaustion	Plerixafor is effective given either preemptively or as a rescue strategy in poor stem cell mobilizing patients with multiple myeloma.	25117969
Multiple Myeloma	Stem Cell Exhaustion	Harvest of more than one CD34+ stem cell transplant has become the standard, to ensure the option for a second autologous transplantation in patients with relapsed or progressive multiple myeloma (MM).	25117969
Multiple Myeloma	Stem Cell Exhaustion	Based on the presented data, we propose an algorithm for the use of plerixafor for CD34+ stem cell mobilization and harvesting in poor mobilizing myeloma patients.	25117969
Malignant tumor of cervix, Specialty Type - cancer	Stem Cell Exhaustion	Hiwi facilitates chemoresistance as a cancer stem cell marker in cervical cancer.	25119492
Specialty Type - cancer	Stem Cell Exhaustion	In addition, as a cancer stem cell marker, Hiwi promoted the tumorsphere formation in vitro and tumorigenicity in vivo and elevated the expression of several stem cell self-renewal-associated transcription factors, in spite of inhibited the proliferation.	25119492
Malignant Neoplasms	Stem Cell Exhaustion	Hiwi, also named PiwiL1, is a human homologue of the Piwi family which is associated with stem cells and is overexpressed in several types of cancers.	25119492
diabetic	Stem Cell Exhaustion	The purpose of this study was to analyze whether adipose-derived mesenchymal stem cells (AD-MSCs) sourced from diabetic and elderly patients have a reduced ability to promote human smooth muscle cell (SMC) migration and differentiation potential toward SMCs, two important processes in stem cell-based tissue engineering of vascular grafts.	25119584
diabetic	Stem Cell Exhaustion	Autologous tissue-engineered blood vessels (TEBVs) generated using adult stem cells have shown promising results, but many preclinical evaluations do not test the efficacy of stem cells from patient populations likely to need therapy (i.e., elderly and diabetic humans).	25119584
Glioma, Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cell-related (CSC) markers have been suggested to have promising potentials as novel types of prognostic and predictive markers in gliomas.	25120750
Childhood Breast Carcinoma	Stem Cell Exhaustion	The specific mechanism underlying the role of putative stem cell marker aldehyde dehydrogenase 1 (ALDH1) playing in development and progression of breast cancer is currently unclear.	25120797
Aplastic Anemia	Stem Cell Exhaustion	Graft failure and survival are the major problems for patients with aplastic anemia undergoing hematopoietic stem cell transplantation (HSCT).	25123053
Childhood Breast Carcinoma	Stem Cell Exhaustion	Yet, the expressions of EMT markers, EMT core regulators, and a stem cell marker of BMI1 during chemotherapy have been poorly analyzed in clinical breast cancer specimens.	25123151
Spinal Cord Injuries	Stem Cell Exhaustion	Long-distance axonal growth from human induced pluripotent stem cells after spinal cord injury.	25123310
Spinal Cord Injuries	Stem Cell Exhaustion	Human induced pluripotent stem cells (iPSCs) from a healthy 86-year-old male were differentiated into neural stem cells and grafted into adult immunodeficient rats after spinal cord injury.	25123310
Chronic heart failure	Stem Cell Exhaustion	Predictive value of apoptotic microparticles to mononuclear progenitor cells ratio in advanced chronic heart failure patients.	25123603
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Concentrations of cutaneous T-cell attracting chemokine, eotaxin, hepatocyte growth factor, interleukin 6 (IL-6), IL-16, and stem cell factor are significantly higher in COPD patients compared with in control patients.	25125975
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Notably, this study identifies stem cell factor as a biomarker for COPD.	25125975
Specialty Type - cancer	Stem Cell Exhaustion	Experimental evidences found in cancer cells a deregulated expression of some genes involved in governance of stem cell properties and demonstrated a relationship between stemness genes overexpression and poorly differentiated BC subtypes.	25127259
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Necessary stem cell transplantation using myeloablative therapy for myelodysplastic syndrome with progression of genotypic abnormalities and TP53 dysfunction in a young adult.	25130056
Lymphoma, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Collection of sufficient CD34+ cells for autologous peripheral blood stem cell (PBSC) transplantation is frequently failed in patients with lymphoma or multiple myeloma (MM).	25130876
leukemia	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation for T-prolymphocytic leukemia: a report from the French society for stem cell transplantation (SFGM-TC).	25130897
leukemia	Stem Cell Exhaustion	Leukemia cells invaded the central nervous system following hematopoietic stem cell transplantation, and the patient died 5 months after being diagnosed with leukemia.	25131874
Allogeneic Hematopoietic Stem Cell Transplantation, Hematologic Neoplasms	Stem Cell Exhaustion	Sequential infusion of donor-derived dendritic cells with donor lymphocyte infusion for relapsed hematologic cancers after allogeneic hematopoietic stem cell transplantation.	25132538
Cytomegalovirus Infections	Stem Cell Exhaustion	Incidence and dynamics of active cytomegalovirus infection in allogeneic stem cell transplant patients according to single nucleotide polymorphisms in donor and recipient CCR5, MCP-1, IL-10, and TLR9 genes.	25132583
Cytomegalovirus DNA	Stem Cell Exhaustion	The current study aimed to investigate whether donor and recipient SNPs in the chemokine receptor 5 (rs1800023), monocyte chemoattractant protein 1 (rs13900), interleukin-10 (rs1878672), and Toll-like receptor 9 (rs352140) genes would exert any influence on the rate of incidence and features of CMV DNAemia in the allogeneic stem cell transplantation setting.	25132583
Anger, Usual Severity Pain	Stem Cell Exhaustion	Anger, provider responses, and pain: prospective analysis of stem cell transplant patients.	25133836
Multiple Myeloma	Stem Cell Exhaustion	We examined whether elevated serum LDH at diagnosis remains an adverse risk factor independent of ISS for survivals transplant-eligible myeloma patients receiving early/frontline bortezomib-based induction, followed by autologous stem cell transplantation (ASCT).	25135740
Blastic plasmacytoid dendritic cell neoplasm	Stem Cell Exhaustion	Sustained remission of blastic plasmacytoid dendritic cell neoplasm after unrelated allogeneic stem cell transplantation--a single center experience.	25138222
Chronic Ocular Graft Versus Host Disease, Dry Eye Syndromes, Stable chronic Graft vs Host Disease	Stem Cell Exhaustion	To first describe in vivo confocal microscopic (IVCM) corneal findings in severe dry eye syndrome due to ocular chronic graft versus host disease (cGvHD) after allogeneic stem cell transplantation.	25138762
Cytomegalovirus Infections	Stem Cell Exhaustion	Cytomegalovirus infection in patients who underwent allogeneic hematopoietic stem cell transplantation in Portugal: a five-year retrospective review.	25139217
Communicable Diseases	Stem Cell Exhaustion	Cytomegalovirus (CMV) infection is 1 of the leading causes of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (aHSCT), mainly within the first 100 days after transplantation.	25139217
Multiple Myeloma	Stem Cell Exhaustion	Safety and efficacy of targeted-dose busulfan and bortezomib as a conditioning regimen for patients with relapsed multiple myeloma undergoing a second autologous blood progenitor cell transplantation.	25139216
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Results of allogeneic stem cell transplantation in the Spanish MDS registry: prognostic factors for low risk patients.	25139847
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Although new agents have been approved for the treatment of MDS, the only curative approach is allogeneic hematopoietic stem cell transplantation (HSCT) and thus, in particular circumstances this procedure has been proposed as a treatment option for low risk patients.	25139847
Spermatocytic seminoma, Seminoma, Neoplasms, Nonseminomatous	Stem Cell Exhaustion	The current opinion is that seminoma and nonseminomatous germ cell tumors develop from a common primitive progenitor cell, whereas spermatocytic seminomas develop from differentiated spermatogonia.	25141494
Chronic granulomatous disease	Stem Cell Exhaustion	Mobilization characteristics and strategies to improve hematopoietic progenitor cell mobilization and collection in patients with chronic granulomatous disease and severe combined immunodeficiency.	25143186
Chronic granulomatous disease	Stem Cell Exhaustion	Granulocyte-colony-stimulating factor (G-CSF)-mobilized autologous hematopoietic progenitor cells (HPCs) may be collected by apheresis of patients with chronic granulomatous disease (CGD) and severe combined immunodeficiency (SCID) for use in gene therapy trials.	25143186
Disease	Stem Cell Exhaustion	Our findings present the concept of organotopic transplantation of macrophage progenitors as an effective and long-lasting therapy of herPAP and may also serve as a proof of principle for other diseases, expanding current stem cell-based strategies toward potent concepts using the transplantation of differentiated cells.	25143363
Reperfusion Injury	Stem Cell Exhaustion	Effect of preemptive treatment with human umbilical cord blood-derived mesenchymal stem cells on the development of renal ischemia-reperfusion injury in mice.	25143451
Immune-mediated	Stem Cell Exhaustion	Human umbilical cord blood-derived mesenchymal stem cells (HUCB-MSCs) have been studied in several models of immune-mediated disease because of their unique immunomodulatory properties.	25143451
Neuroendocrine Tumors, Malignant neoplasm of lung	Stem Cell Exhaustion	We evaluated the expression of the oncofetal protein IMP3 in a series of neuroendocrine tumors of the lung, correlating our results with proliferating index Ki67 and with the expression of the two most studied stem cell markers in lung cancer, Nanog and Oct3/4.	25144243
Neuroendocrine Tumors	Stem Cell Exhaustion	IMP3 is a marker of poor outcome in lung neuroendocrine tumors; its correlation with Nanog expression suggest an implication of IMP3 in stem cell processes and its association with a Ki67 labeling index higher than 4% stratifies a subset of atypical carcinoids with a higher risk of recurrence and mortality.	25144243
Graft-vs-Host Disease, Myelosuppression, Lymphoma	Stem Cell Exhaustion	Myelosuppression, graft-versus-host disease (GVHD), and relapse remain major causes of morbidity after stem cell transplantation for relapsed lymphoma.	25145344
Squamous cell carcinoma of esophagus	Stem Cell Exhaustion	A retrospective review of the prognostic value of ALDH-1, Bmi-1 and Nanog stem cell markers in esophageal squamous cell carcinoma.	25148045
Malignant Neoplasms	Stem Cell Exhaustion	Stem cell markers are upregulated in various cancers and have potential as prognostic indicators.	25148045
Extrapulmonary Small Cell Carcinoma, Squamous cell carcinoma of esophagus, leukemia	Stem Cell Exhaustion	The objective of this study was to determine the expression of three stem cell markers, aldehyde dehydrogenase 1 (ALDH-1), B cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1), and Nanog, in esophageal squamous cell carcinoma (ESCC) tissues.	25148045
Extrapulmonary Small Cell Carcinoma	Stem Cell Exhaustion	Further large studies are necessary to fully elucidate the prognostic value of these stem cell markers for ESCC patients.	25148045
Aggressive Non-Hodgkin Lymphoma, tetraxetan	Stem Cell Exhaustion	We evaluated the anti-CD22 (90)Y-epratuzumab tetraxetan with the anti-CD20 veltuzumab in patients with aggressive lymphoma in whom at least one prior standard treatment had failed, but who had not undergone stem cell transplantation.	25150258
Osteoporotic Fractures	Stem Cell Exhaustion	Mesenchymal stem cells from osteoporotic patients reveal reduced migration and invasion upon stimulation with BMP-2 or BMP-7.	25152406
Fracture	Stem Cell Exhaustion	Human mesenchymal stem cells (hMSC), the cellular source of fracture healing, are recruited to the fracture site by cytokines, such as BMP-2 and BMP-7.	25152406
Aggressive course	Stem Cell Exhaustion	MicroRNA-101 targets EZH2, MCL-1 and FOS to suppress proliferation, invasion and stem cell-like phenotype of aggressive endometrial cancer cells.	25153722
Hepatitis B, REG1CP gene	Stem Cell Exhaustion	Hepatitis B virus (HBV) reverse seroconversion (RS) can be prevented even in non-responders to hepatitis B vaccine after allogeneic stem cell transplantation: long-term analysis of intervention in RS with vaccine for patients with previous HBV infection.	25154638
Hepatitis B, REG1CP gene, Communicable Diseases	Stem Cell Exhaustion	Reactivation of hepatitis B virus (HBV) infection, reverse seroconversion (RS), is a serious complication after allogeneic stem cell transplantation (alloHSCT).	25154638
Mastocytosis	Stem Cell Exhaustion	Hematopoietic stem-cell transplantation for advanced systemic mastocytosis.	25154823
Neurodegenerative Disorders	Stem Cell Exhaustion	Developing neural stem cell-based treatments for neurodegenerative diseases.	25157920
Alzheimers Disease	Stem Cell Exhaustion	The recent discovery by Blurton-Jones and colleagues that neural stem cells can effectively deliver disease-modifying therapeutic proteins throughout the brains of our best rodent models of Alzheimer's disease, combined with recent advances in human nuclear reprogramming, stem cell research, and highly customized genetic engineering, may represent a potentially revolutionary personalized cellular therapeutic approach capable of effectively curing, ameliorating, and/or slowing the progression of Alzheimer's disease.	25157920
Medial collateral ligament	Stem Cell Exhaustion	For younger patients, intensive approaches followed by autologous stem cell transplantation offer excellent long-term disease control but with the possible exception of an allogenic stem cell transplant, MCL is an incurable condition.	25158606
Psoriasis	Stem Cell Exhaustion	Characterization and profiling of immunomodulatory genes in resident mesenchymal stem cells reflect the Th1-Th17/Th2 imbalance of psoriasis.	25160906
Psoriasis	Stem Cell Exhaustion	The microenvironment exerts a control on the phenotype of resident mesenchymal stem cells (MSCs) into the skin of psoriasis patients.	25160906
Polycythemia Vera	Stem Cell Exhaustion	Polycythemia vera is the ultimate phenotypic consequence of the V617F mutation in Janus kinase 2 (encoded by JAK2), but the extent to which this mutation influences the behavior of the involved CD34+ hematopoietic stem cells is unknown.	25162887
Neoplasms	Stem Cell Exhaustion	Differences among brain tumor stem cell types and fetal neural stem cells in focal regions of histone modifications and DNA methylation, broad regions of modifications, and bivalent promoters.	25163646
Glioblastoma Multiforme Pathway, Neoplasms	Stem Cell Exhaustion	Using ChIP-chip and MeDIP-chip approaches, we localized well-established and prevalent epigenetic marks (H3K27me3, H3K4me3, H3K9me3, DNA methylation) on a genome scale in several lines of putative glioma stem cells (brain tumor stem cells, BTSCs) and, for comparison, normal human fetal neural stem cells (fNSCs).	25163646
Childhood Breast Carcinoma	Stem Cell Exhaustion	Metastatic consequences of immune escape from NK cell cytotoxicity by human breast cancer stem cells.	25164008
Graft-vs-Host Disease	Stem Cell Exhaustion	Lower dose of antithymocyte globulin does not increase graft-versus-host disease in patients undergoing reduced-intensity conditioning allogeneic hematopoietic stem cell transplant.	25166008
Chronic Obstructive Airway Disease, physiopathological	Stem Cell Exhaustion	Circulating progenitor cells and vascular dysfunction in chronic obstructive pulmonary disease.	25171153
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	In chronic obstructive pulmonary disease (COPD), decreased progenitor cells and impairment of systemic vascular function have been suggested to confer higher cardiovascular risk.	25171153
Pulmonary Hypertension	Stem Cell Exhaustion	To investigate whether changes in the number of circulating hematopoietic progenitor cells are associated with pulmonary hypertension or changes in endothelial function.	25171153
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Compared with controls, the number of circulating progenitor cells was reduced in COPD patients.	25171153
Chronic Obstructive Airway Disease, Pulmonary Hypertension	Stem Cell Exhaustion	COPD patients with pulmonary hypertension showed greater number of progenitor cells than those without pulmonary hypertension.	25171153
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	In COPD patients, the number of circulating progenitor cells was inversely related to the flow-mediated dilation of systemic arteries.	25171153
Graft-vs-Host Disease	Stem Cell Exhaustion	Uric acid (UA) is a known danger signal and is released from injured cells during conditioning for allogeneic hematopoietic stem cell transplantation (HSCT), but its role in GVHD is unclear.	25172456
TCL4 gene, Adult T-Cell Lymphoma/Leukemia	Stem Cell Exhaustion	Allogeneic bone marrow and peripheral blood stem cell transplantations are curative treatment modalities for adult T cell leukemia/lymphoma (ATLL) because of the intrinsic graft-versus-ATLL effect.	25172635
Malignant neoplasm of stomach, Malignant Neoplasms	Stem Cell Exhaustion	CD24 is a heavily glycosylated cell surface protein that is expressed in putative stem cells and is overexpressed in various human malignancies, yet the significant roles of CD24 in gastric cancer development are still elusive.	25174257
Neoplasms, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	These observations warrant further research on CART-33 treatment in refractory AML and may spur efforts to extend the CART-33-induced tumor burden to the preparation of other intensive strategies, such as hematopoietic stem cell transplantation.	25174587
Mantle cell lymphoma	Stem Cell Exhaustion	R-CHOP or R-HyperCVAD with or without autologous stem cell transplantation for older patients with mantle cell lymphoma.	25174772
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	Although intensive induction and autologous stem cell transplantation (ASCT) prolong survival in younger patients with mantle cell lymphoma (MCL), benefit in older patients remains uncertain because data supporting these approaches come almost exclusively from younger cohorts.	25174772
Infancy, Medulloblastoma	Stem Cell Exhaustion	Proposed strategy for the use of high-dose chemotherapy with stem cell rescue and intrathecal topotecan without whole-brain irradiation for infantile classic medulloblastoma.	25174961
Amyloidosis	Stem Cell Exhaustion	Marked and rapid regression of hepatic amyloid deposition in a patient with systemic light chain (AL) amyloidosis after high-dose melphalan therapy with stem cell transplantation.	25175136
Prostate carcinoma	Stem Cell Exhaustion	Differential expression of stem cell markers and ABCG2 in recurrent prostate cancer.	25175483
Neoplasms, Passive Cutaneous Anaphylaxis	Stem Cell Exhaustion	The aim of this research is to investigate expressions of stem cell markers in recurrent PCa and non-recurrent PCa tumors as well as in adjacent normal prostate tissues.	25175483
Specialty Type - cancer	Stem Cell Exhaustion	Enhanced expression of ABCG2 and stem cell markers including SOX2, OCT4, and KLF4 in the recurrent PCa tissues postulates the suggestion that enrichment for cells with stem cell characteristics in these tissues might be playing a critical role for chemoresistance and recurrence of cancer.	25175483
Specialty Type - cancer, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Cancer stem cells are composed of a small cell population, which are supposed to have roles in tumorigenesis, metastasis, and tumor recurrence after chemo-radiotherapy.	25175483
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Favorable outcomes in elderly patients undergoing high-dose therapy and autologous stem cell transplantation for non-Hodgkin lymphoma.	25175794
Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	High-dose therapy and autologous stem cell transplantation (HDT-ASCT) can offer potential long-term remission or cure in patients with non-Hodgkin lymphoma (NHL).	25175794
Myeloproliferative disease, Malignant Neoplasms, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of the hematopoietic stem cell that is exceptionally rare in the first five years of life, particularly as a secondary malignancy.	25175922
Carcinoma	Stem Cell Exhaustion	The characterization of stem cell in this type of carcinoma could determine the appearance of new ideas concerning origin and evolution.	25178326
Noninfiltrating Intraductal Carcinoma	Stem Cell Exhaustion	There is an impressive amount of data in the literature related to TNBC and a growing interest for stem cell research during the past years, but there are no data concerning the genetic characterization of stem cells in the context of cell biology of TNBC as compared with associated DCIS.	25178326
Noninfiltrating Intraductal Carcinoma	Stem Cell Exhaustion	We performed immunohistochemical studies for the expression and distribution of several stem cell-related antigens, focusing on the association of TNBC with DCIS and comparing the presence of stem cells in the invasive and in the in situ component.	25178326
Breast Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells biomarkers in triple negative invasive carcinoma of the breast and associated in situ lesions.	25178326
Childhood Breast Carcinoma	Stem Cell Exhaustion	Optimization of detection, identification and characterization of tumorigenic breast cancer stem cells might permit further identification of targeted treatment.	25178326
Ptosis	Stem Cell Exhaustion	This is an observational study is designed to assess the influence of age, prolapse and medical co-morbidities on myogenic stem cells growth in-vitro.	25181379
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The emergence of oligoclonal bands (OB) has been reported in patients with multiple myeloma (MM) after stem cell transplantation (SCT) or successful chemotherapy.	25182124
Multiple Myeloma	Stem Cell Exhaustion	This open-label, randomized, phase 3 study compared melphalan at a dose of 200 mg per square meter of body-surface area plus autologous stem-cell transplantation with melphalan-prednisone-lenalidomide (MPR) and compared lenalidomide maintenance therapy with no maintenance therapy in patients with newly diagnosed multiple myeloma.	25184862
Cessation of life	Stem Cell Exhaustion	Both progression-free and overall survival were significantly longer with high-dose melphalan plus stem-cell transplantation than with MPR (median progression-free survival, 43.0 months vs. 22.4 months; hazard ratio for progression or death, 0.44; 95% confidence interval [CI], 0.32 to 0.61; P<0.001; and 4-year overall survival, 81.6% vs. 65.3%; hazard ratio for death, 0.55; 95% CI, 0.32 to 0.93; P=0.02).	25184862
Multiple Myeloma	Stem Cell Exhaustion	Consolidation therapy with high-dose melphalan plus stem-cell transplantation, as compared with MPR, significantly prolonged progression-free and overall survival among patients with multiple myeloma who were 65 years of age or younger.	25184862
Multiple Myeloma	Stem Cell Exhaustion	The combination melphalan-prednisone-thalidomide (MPT) is considered a standard therapy for patients with myeloma who are ineligible for stem-cell transplantation.	25184863
Multiple Myeloma	Stem Cell Exhaustion	As compared with MPT, continuous lenalidomide-dexamethasone given until disease progression was associated with a significant improvement in progression-free survival, with an overall survival benefit at the interim analysis, among patients with newly diagnosed multiple myeloma who were ineligible for stem-cell transplantation.	25184863
Vascular neoplasm of skin, Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	An agent-based model of cancer stem cell initiated avascular tumour growth and metastasis: the effect of seeding frequency and location.	25185580
Vascular neoplasm of skin, Childhood Breast Carcinoma	Stem Cell Exhaustion	Here, we investigate stem cell seeding to an avascular tumour site using an agent-based stochastic model of breast cancer metastatic seeding.	25185580
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	There is increasing evidence that cancer stem cells are closely linked to the progression of the metastatic tumour.	25185580
Multiple Myeloma	Stem Cell Exhaustion	Activation of LTBP3 gene by a long noncoding RNA (lncRNA) MALAT1 transcript in mesenchymal stem cells from multiple myeloma.	25187517
Multiple Myeloma	Stem Cell Exhaustion	Here we explored the biology of the lncRNA MALAT1 and considered the potential significance in mesenchymal stem cells from myeloma patients.	25187517
Neoplasms	Stem Cell Exhaustion	Supervised analyses reveal that pure basaloid tumors display a specific mRNA expression profile, encoding factors controlling the cell cycle, transcription, chromatin, and splicing, with prevalent expression in germline and stem cells, while genes related to squamous differentiation are underexpressed.	25189482
Endothelial dysfunction	Stem Cell Exhaustion	Among these, an altered balance between endothelial microparticle (EMP) release and endothelial progenitor cell (EPC) generation promotes endothelial dysfunction.	25190637
Sjogrens Syndrome	Stem Cell Exhaustion	Characterization of circulating endothelial microparticles and endothelial progenitor cells in primary Sjogren's syndrome: new markers of chronic endothelial damage?	25190637
Kidney Failure, Acute	Stem Cell Exhaustion	Urinary liver-type fatty acid-binding protein linked with increased risk of acute kidney injury after allogeneic stem cell transplantation.	25193082
Kidney Failure, Acute	Stem Cell Exhaustion	Stem cell transplantation (SCT) involves a great risk of acute kidney injury (AKI).	25193082
Bipolar Disorder	Stem Cell Exhaustion	The study aims to evaluate the mediating effect of depressive symptoms on the relationship between physical symptoms and health-related quality of life (HRQOL) in hematopoietic stem cell transplant (HSCT) survivors and to test a conceptual model of psychosocial factors, in addition to physical and psychological symptoms, that might contribute to HRQOL.	25193598
Primary Myelofibrosis	Stem Cell Exhaustion	JAK2 inhibitors do not affect stem cells present in the spleens of patients with myelofibrosis.	25193869
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	ALOX5 is implicated in chronic myeloid leukemia development in mouse leukemic stem cells, but its importance in human chronic myeloid leukemia is unknown.	25193960
Gammopathy, Multiple Myeloma	Stem Cell Exhaustion	Secondary monoclonal gammopathy of undetermined significance after allogeneic stem cell transplantation in multiple myeloma.	25193963
Gammopathy	Stem Cell Exhaustion	In this retrospective single center analysis, we describe the occurrence and clinical relevance of secondary monoclonal gammopathy of undetermined significance after allogeneic stem cell transplantation (post-transplant monoclonal gammopathy of undetermined significance).	25193963
Multiple Myeloma	Stem Cell Exhaustion	A total of 138 patients who had undergone 139 allogeneic stem cell transplantations (39.6% in the upfront setting and 60.4% for relapsed multiple myeloma) were included in the study.	25193963
Gammopathy	Stem Cell Exhaustion	Secondary monoclonal gammopathy of undetermined significance occurred more often in patients who achieved at least very good partial response after allogeneic stem cell transplantation, compared to partial response or less (54.8% vs. 26.5%; P=0.005).	25193963
Lymphoma, Follicular, Lymphoma	Stem Cell Exhaustion	The impact of total body irradiation on the outcome of patients with follicular lymphoma treated with autologous stem-cell transplantation in the modern era: a retrospective study of the EBMT Lymphoma Working Party.	25193988
Lymphoma, Follicular	Stem Cell Exhaustion	The aim of this study was to investigate the impact of the high-dose regimen on the outcome of patients with follicular lymphoma (FL) having had autologous stem-cell transplantation (ASCT) in a recent time period.	25193988
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Outcome of allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia patients with central nervous system involvement.	25196856
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Therefore, CNS involvement in AML is an indicator for allogeneic hematopoietic stem cell transplantation (allo-HSCT).	25196856
Diabetes Mellitus, Insulin-Dependent, diabetic	Stem Cell Exhaustion	Combined therapy of insulin-producing cells and haematopoietic stem cells offers better diabetic control than only haematopoietic stem cells' infusion for patients with insulin-dependent diabetes.	25199184
Failure, Specialty Type - cancer, Hypoxia	Stem Cell Exhaustion	Hypoxia induced by antiangiogenic agents is linked to the generation of cancer stem cells (CSCs) and treatment failure through unknown mechanisms.	25200065
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The malignant cell population of acute myeloid leukemia (AML) includes a small population of stem/progenitor cells with long-term in vitro proliferation.	25200484
Immunoblastic Large-Cell Lymphoma	Stem Cell Exhaustion	Plasmablastic lymphoma of the breast in an immunocompetent patient: long-lasting complete response induced by chemotherapy and autologous stem cell trasplantation.	25202100
Intervertebral Disk Displacement	Stem Cell Exhaustion	Gene expression profile analysis of human mesenchymal stem cells from herniated and degenerated intervertebral discs reveals different expression of osteopontin.	25203751
Acute myocardial infarction	Stem Cell Exhaustion	Detection of CD34/CXCR4+ stem cells in peripheral blood of patients following acute myocardial infarction.	25204042
Chest Pain, Diabetes, Myocardial Reperfusion Injury, Acute myocardial infarction	Stem Cell Exhaustion	The aim of this study was to answer the question whether acute myocardial infarction (AMI) related stress may trigger the increase of CD34/CXCR4+ stem cells number in peripheral blood in response to myocardial ischemic injury which might be accompanied with increased release of this population of stem cells in peripheral blood as well as to correlate this phenomenon with other clinical and laboratory parameters such as diabetes, chest pain, smoking, streptokinase administration and elevated cardiac enzymes.	25204042
Chemical injury, Infarction	Stem Cell Exhaustion	In conclusion, there is a pool of CD34/CXCR4+ stem cells circulating in large number in peripheral blood of AMI patients post infarction together with low CXCR4 expression on these cells which are likely to contribute to myocardial repair following the acute ischemic injury.	25204042
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Phase 2 trial of high-dose rituximab with high-dose cytarabine mobilization therapy and high-dose thiotepa, busulfan, and cyclophosphamide autologous stem cell transplantation in patients with central nervous system involvement by non-Hodgkin lymphoma.	25204639
Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	High-dose thiotepa, busulfan, and cyclophosphamide (TBC) with autologous stem cell transplantation (ASCT) has been used in patients with central nervous system (CNS) involvement by non-Hodgkin lymphoma (NHL).	25204639
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We conclude that the incidence of TB is significantly higher in CML patients of male sex, aged >= 60, having received either stem cell transplantation or interferon-a treatment.	25208807
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Combined carboplatin/paclitaxel treatment of PDX tumors enriches the cancer stem cell populations, but persistent tumors are not entirely composed of these populations.	25209969
Specialty Type - cancer	Stem Cell Exhaustion	The importance of the endothelium in angiogenesis and cancer is undisputed, and its integrity may be assessed by laboratory markers such as circulating endothelial cells (CECs), endothelial progenitor cells (EPCs), plasma von Willebrand factor (vWf), soluble E selectin, vascular endothelial growth factor (VEGF) and angiogenin.	25211664
Lichen Planus	Stem Cell Exhaustion	Interferon-g regulates the function of mesenchymal stem cells from oral lichen planus via indoleamine 2,3-dioxygenase activity.	25212102
Hearing Loss, Partial	Stem Cell Exhaustion	Endothelial progenitor cells in patients with age-related hearing loss.	25212104
Hearing Loss, Partial	Stem Cell Exhaustion	The possible role of circulating epithelial progenitor cells in the pathogenesis of age related hearing loss should be considered based on their significant reduction in patients with ARHL, although the association alone does not prove causality.	25212104
hematopoietic stem cell migration to bone marrow, MYELODYSPLASTIC SYNDROME, Cytopenia	Stem Cell Exhaustion	Myelodysplastic syndromes are a heterogeneous group of clonal bone marrow hematopoietic stem cell disorders characterized by ineffective hematopoiesis and peripheral cytopenias.	25216221
Infiltration	Stem Cell Exhaustion	While T3 were mainly composed by platelets and fibrin(ogen), T6 were characterized by a reduced platelet content, increased leucocytes infiltration (including monocytes, neutrophils, T-cells, and B-cells), and appearance of undifferentiated progenitor cells.	25217443
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Myelodysplastic syndromes are clonal disorders of stem cells, characterized by heterogeneous clinical presentation.	25217620
Palmar-plantar erythrodysesthesia syndrome, Multiple Myeloma	Stem Cell Exhaustion	GWAS of 972 autologous stem cell recipients with multiple myeloma identifies 11 genetic variants associated with chemotherapy-induced oral mucositis.	25218607
Malignant Neoplasms, Multiple Myeloma, Pregnancy Complications, Infectious, Gastrointestinal mucositis, Usual Severity Pain, Morular Metaplasia of the Endometrium	Stem Cell Exhaustion	High-dose chemotherapy and autologous stem cell transplant (ASCT) to treat multiple myeloma (MM) and other cancers carries the risk of oral mucositis (OM) with sequelae including impaired nutritional and fluid intake, pain, and infectious complications.	25218607
Neoplasms, Porphyromonas gingivalis	Stem Cell Exhaustion	The GroEL protein of Porphyromonas gingivalis accelerates tumor growth by enhancing endothelial progenitor cell function and neovascularization.	25220060
Carcinoma	Stem Cell Exhaustion	Here, we investigated the effects of P. gingivalis GroEL on neovasculogenesis in C26 carcinoma cell-carrying BALB/c mice and chick eggs in vivo as well as its effect on human endothelial progenitor cells (EPC) in vitro.	25220060
PAFAH1B1 wt Allele, Acute leukemia	Stem Cell Exhaustion	It is well accepted that genomic instability in dysplastic hematopoietic stem/progenitor cells (HSPC) drives the evolution of MDS to acute leukemia.	25220590
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Impact of early remission by induction therapy on allogeneic stem cell transplantation for acute myeloid leukemia with an intermediate-risk karyotype in first complete remission.	25220715
GDC Disease Response Terminology, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Here, we retrospectively examined the prognostic impact of early remission (ER) vs. delayed remission (DR) in a cohort of 132 AML patients with an intermediate-risk karyotype undergoing allogeneic stem cell transplantation (alloSCT) in first complete remission (CR1).	25220715
leukemia	Stem Cell Exhaustion	To the best of our knowledge, this is the first report of IHA that was not induced by intensive chemotherapy, stem cell transplantation, or asparaginase therapy in a patient with newly diagnosed leukemia, but developed during an initial treatment with a steroid.	25222063
Lymphadenopathy, Lymphoproliferative Disorders	Stem Cell Exhaustion	Manifestations of fulminant CD8 T-cell post-transplant lymphoproliferative disorder following the administration of rituximab for lymphadenopathy with a high level of Epstein-Barr Virus (EBV) replication after allogeneic hematopoietic stem cell transplantation.	25224199
Aplastic Anemia	Stem Cell Exhaustion	We herein report the case of a 22-year-old woman with severe aplastic anemia who underwent allogeneic hematopoietic stem cell transplantation (HSCT).	25224199
Graft-vs-Host Disease	Stem Cell Exhaustion	Steroid-refractory graft-versus-host disease (GVHD) is a major and often fatal complication after allogeneic stem-cell transplantation (alloSCT).	25225421
Chronic Obstructive Airway Disease, Pulmonary Hypertension	Stem Cell Exhaustion	Changes of Number and Function of Late Endothelial Progenitor Cells in Peripheral Blood of COPD Patients Combined with Pulmonary Hypertension.	25226359
Chronic Obstructive Airway Disease, Pulmonary Hypertension	Stem Cell Exhaustion	Objective The objective of this study was to investigate the changes of number and function of late endothelial progenitor cells (EPCs) in peripheral blood of chronic obstructive pulmonary disease (COPD) patients combined with pulmonary hypertension.	25226359
gastrointestinal	Stem Cell Exhaustion	Patients undergoing hematopoietic stem cell transplant (HSCT) can experience gastrointestinal (GI) side effects as a complication of the treatment.	25227122
Precursor cell lymphoblastic lymphoma, Lymphoid neoplasm, Dendritic Cells	Stem Cell Exhaustion	Unique composite hematolymphoid tumor consisting of a pro-T lymphoblastic lymphoma and an indeterminate dendritic cell tumor: evidence for divergent common progenitor cell differentiation.	25228298
Lymphoid neoplasm	Stem Cell Exhaustion	In the last years, evidence for transdifferentiation from one cell lineage to another or divergent common progenitor cell differentiation has accumulated, mainly based on composite hematolymphoid tumors, sharing common genetic abnormalities.	25228298
teratologic, Lymphoid neoplasm	Stem Cell Exhaustion	The synchronous appearance of two distinct uncommon hematolymphoid tumors in the same patient, recurrent at three different anatomic locations, with an identifiable common genetic denominator, namely +21, but also with unique genetic anomalies in the pro-T LBL raises the hypothesis of a divergent common progenitor cell differentiation.	25228298
Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Clinical outcomes of a novel combination of lenalidomide and rituximab followed by stem cell transplantation for relapsed/refractory aggressive B-cell non-hodgkin lymphoma.	25228589
Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	We retrospectively compared outcomes of patients with relapsed/refractory non-Hodgkin lymphoma (NHL) who underwent stem cell transplantation (SCT) with stable disease or better following a novel combination of lenalidomide and rituximab (LR) treatment and did not undergo SCT in a phase I/II clinical trial.	25228589
Specialty Type - cancer	Stem Cell Exhaustion	Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell.	25228591
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSCs) retain the capacity to propagate themselves through self-renewal and to produce heterogeneous lineages of cancer cells constituting the tumor.	25228591
Lung Diseases, Interstitial, PICALM gene	Stem Cell Exhaustion	Preoperatively, interstitial lung disease was more common in LDLLT patients than in CLT patients (47.6 vs 24.3%, P = 0.048); prior haematopoietic stem cell transplantation was performed more often in LDLLT patients than in CLT patients (33.3 vs 13.5%, P = 0.040) and there were more steroid-dependent LDLLT patients than CLT patients (64.3 vs 29.7%, P = 0.0022).	25228745
Steroid-Refractory Pneumonitis	Stem Cell Exhaustion	Etanercept for steroid-refractory acute graft versus host disease following allogeneic hematopoietic stem cell transplantation.	25228839
Graft-vs-Host Disease, Steroid-Refractory Pneumonitis	Stem Cell Exhaustion	The treatment for steroid-refractory acute graft versus host disease (GVHD) after allogeneic stem cell transplantation (allo-SCT) needs to be standardized.	25228839
Neoplasms	Stem Cell Exhaustion	Cells with stem cell-like properties have been identified in tumors from a variety of origins, but to our knowledge there are yet no reports on tumor-related stem cells in the human upper respiratory tract.	25229469
Neoplasms	Stem Cell Exhaustion	These cells, designated as MEi (mesenchymal stem cell-like mucoepidermoid tumor) cells, could be differentiated towards mesenchymal lineages both with and without induction, and formed spheroids in vitro.	25229469
Angina Pectoris	Stem Cell Exhaustion	Selected CD133+ progenitor cells to promote angiogenesis in patients with refractory angina: final results of the PROGENITOR randomized trial.	25231095
Acute lymphocytic leukemia, Failure, Toxic effect, BCR gene	Stem Cell Exhaustion	We retrospectively studied toxicity and outcome of 71 paediatric patients with acute lymphoblastic leukaemia (ALL) undergoing haematopoietic stem cell transplantation (HSCT) following treosulfan-based conditioning aiming to identify risk factors for treatment failure and dose-depending outcome differences.	25231927
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	The National Marrow Donor Program/Be The Match has collected HLA typing from CLL patients in need of allogeneic hematopoietic stem cell transplant and has recruited millions of volunteers to potentially donate hematopoietic stem cells.	25232063
Specialty Type - cancer	Stem Cell Exhaustion	Exploring the Cancer Experiences of Young Adults in the Context of Stem Cell Transplantation.	25232959
Malignant Neoplasms	Stem Cell Exhaustion	Stem cell transplantation (SCT), a treatment modality for a variety of YA malignancies, often requires prolonged hospitalization and immune-compromising treatment regimens.	25232959
Hepatosplenic T-cell lymphoma, Lymphoma	Stem Cell Exhaustion	Allogeneic and autologous stem cell transplantation for hepatosplenic T-cell lymphoma: a retrospective study of the EBMT Lymphoma Working Party.	25234166
Peripheral T-Cell Lymphoma, Hepatosplenic T-cell lymphoma	Stem Cell Exhaustion	The objective of this registry study was to analyse the outcome of patients who underwent allogeneic or autologous haematopoietic stem cell transplantation (HSCT) for hepatosplenic T-cell lymphoma (HSTL), a rare and extremely aggressive peripheral T-cell lymphoma subtype.	25234166
Cessation of life, Multiple Organ Failure	Stem Cell Exhaustion	The main causes of death were complications from haematopoietic stem-cell transplantation and multiorgan failure.	25234411
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The efficacy and safety of plerixafor, an antagonist of the CXCR4 receptor, in combination with G-CSF has been demonstrated in patients suffering from Iymphoma and multiple myeloma (MM) eligible for autologous haematopoietic stem cell collection.	25236359
Hodgkin Disease, Multiple Myeloma, Childhood Non-Hodgkin Lymphoma, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This was a phase 1/2, randomized, observer-blind, placebo-controlled study in adults with multiple myeloma, non-Hodgkin lymphoma (B- or T-cell), Hodgkin lymphoma, or acute myeloid leukemia who had undergone autologous hematopoietic stem-cell transplant 50 to 70 days earlier.	25237196
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Comparison of umbilical cord blood allogeneic stem cell transplantation vs. auto-SCT for adult acute myeloid leukemia patients in second complete remission at transplant: a retrospective study on behalf of the SFGM-TC.	25238651
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This retrospective study considered the outcomes of 181 patients with acute myeloid leukemia (AML) transplanted in second complete remission (CR2) between January 2005 and April 2012 and who received either a myeloablative autologous stem cell transplant (Auto-SCT; n = 82; median age: 48 years; median follow-up: 45 months) or an umbilical cord blood (UCB) allogeneic SCT (n = 99, median age: 46 years; median follow-up: 36 months; conditioning regimens: myeloablative n = 21, reduced n = 78; single unit n = 37, double units n = 62).	25238651
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Phase I trial of maintenance sorafenib after allogeneic hematopoietic stem cell transplantation for fms-like tyrosine kinase 3 internal tandem duplication acute myeloid leukemia.	25239228
FLT3 Internal Tandem Duplication, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutation is associated with a high relapse rate for patients with acute myeloid leukemia (AML) even after allogeneic hematopoietic stem cell transplantation (HSCT).	25239228
Lupus Erythematosus	Stem Cell Exhaustion	High level of reactive oxygen species impaired mesenchymal stem cell migration via overpolymerization of F-actin cytoskeleton in systemic lupus erythematosus.	25239279
Lupus Erythematosus, Encephalitis, St. Louis	Stem Cell Exhaustion	Some lines of evidence have demonstrated abnormalities of bone marrow mesenchymal stem cells (MSCs) in systemic lupus erythematosus (SLE) patients, characterized by defective phenotype of MSCs and slower growth with enhanced apoptosis and senescence.	25239279
Stem Cell Factor	Stem Cell Exhaustion	Plasma levels of vascular endothelial growth factor A (VEGF-A), thrombospondin-1 (TSP-1) and stem cell factor (SCF) were determined by Elisa.	25239280
Specialty Type - cancer	Stem Cell Exhaustion	All except two had underlying cancer, and 47 (35.6%) also received a stem cell transplant.	25239419
Lymphoma, Follicular	Stem Cell Exhaustion	PET/CT before autologous stem cell transplantation predicts outcome in refractory/relapsed follicular lymphoma.	25239490
Lymphoma, Follicular	Stem Cell Exhaustion	Salvage of young patients with follicular lymphoma (FL) after R-CHOP includes salvage immunochemotherapy followed by autologous stem cell transplantation (ASCT).	25239490
Hepatotoxicity	Stem Cell Exhaustion	Possible amlodipine-induced hepatotoxicity after stem cell transplant.	25239629
Hepatotoxicity	Stem Cell Exhaustion	Allogeneic stem cell transplant patients are often prescribed many medications that carry the risk of hepatotoxicity.	25239629
Specialty Type - cancer, Adenocarcinoma of pancreas	Stem Cell Exhaustion	Immunohistochemical analysis of cancer stem cell markers in pancreatic adenocarcinoma patients after neoadjuvant chemoradiotherapy.	25240521
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells (CSCs) have been reported to play an important role in chemoradiation resistance.	25240521
Intrahepatic Route of Drug Administration, Hepatitis C	Stem Cell Exhaustion	Analysis of the intrahepatic ductular reaction and progenitor cell responses in hepatitis C virus recurrence after liver transplantation.	25241637
GDC Disease Response Terminology, Fibrosis Assessment, Hepatitis C	Stem Cell Exhaustion	In livers with HCV infections in the non-LT setting, there is a significant relationship between the development of structures known as the ductular reaction (DR), hepatic progenitor cells (HPCs), and fibrosis.	25241637
Laryngeal Squamous Cell Carcinoma	Stem Cell Exhaustion	Stem cell markers OCT4 and nestin in laryngeal squamous cell carcinoma and their relation to survivin expression.	25242024
Laryngeal Squamous Cell Carcinoma	Stem Cell Exhaustion	We explored the expression of the stem cell markers OCT4 and nestin in laryngeal squamous cell carcinoma (LSCC) and investigated their relationship to survivin expression.	25242024
Hematopoietic stem cells, Haploinsufficiency	Stem Cell Exhaustion	We generated a murine model with conditional inactivation of Csnk1a1 and found that Csnk1a1 haploinsufficiency induces hematopoietic stem cell expansion and a competitive repopulation advantage, whereas homozygous deletion induces hematopoietic stem cell failure.	25242043
Muscular Dystrophy, Sarcopenia	Stem Cell Exhaustion	Finally, clinical situations are outlined where there is a need to enhance skeletal muscle regeneration: these include acute and chronic injuries or transplantation with bioengineering to form new muscles, therapeutic approaches to muscular dystrophies, and comment on proposed stem cell therapies to reduce age-related loss of muscle mass and function.	25242742
Graft-vs-Host Disease, Exanthema	Stem Cell Exhaustion	Skin biopsy was done and showed interface lymphocytic infiltrate that are largely centered on the dermal-epidermal junction, is consistent with GVHD (this pattern of rash distribution is unique and different from the rash of GVHD after hematopoietic stem cell transplant, which is confined to palms of the hands and soles of the feet; Fig 1).	25242798
Spinal Cord Ischemia	Stem Cell Exhaustion	Our findings identify SIRT1 as regulator of hypoxia-induced response in hMSCs and may contribute to the development of new therapeutic strategies to improve regenerative properties of mesenchymal stem cells in ischemic disorders through SIRT1 modulation.	25243179
Graft-vs-Host Disease, Liver Failure	Stem Cell Exhaustion	The patient received an allo-unrelated peripheral blood stem-cell transplantation and expired due to graft-versus-host disease following liver failure.	25243347
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation provides the best chance of long-term survival for patients with AML, but is associated with an unpredictable risk of treatment-related mortality.	25243624
Paroxysmal nocturnal hemoglobinuria	Stem Cell Exhaustion	Together, our data indicate that in addition to PIGA mutations, accessory genetic events are frequent in PNH, suggesting a stepwise clonal evolution derived from a singular stem cell clone.	25244093
Thrombophilia, Hemolysis (biological function), Bone marrow hypocellularity, Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH) is a nonmalignant clonal disease of hematopoietic stem cells that is associated with hemolysis, marrow failure, and thrombophilia.	25244093
Graft-vs-Host Disease, Acute GVH disease, Inflammatory disorder	Stem Cell Exhaustion	Myeloid-derived suppressor cells (MDSCs) are powerful immunomodulatory cells that in mice play a role in infectious and inflammatory disorders, including acute graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation.	25246295
Acute GVH disease	Stem Cell Exhaustion	Graft monocytic myeloid-derived suppressor cell content predicts the risk of acute graft-versus-host disease after allogeneic transplantation of granulocyte colony-stimulating factor-mobilized peripheral blood stem cells.	25246295
Amyloidosis	Stem Cell Exhaustion	We report a retrospective evaluation of the clinical outcome of treatment with bortezomib, melphalan, and prednisolone (VMP) as first-line chemotherapy in patients with AL amyloidosis who were ineligible for autologous stem cell transplant.	25248716
Inflammation, Multiple Myeloma	Stem Cell Exhaustion	Longitudinal analysis of patient-reported symptoms post-autologous stem cell transplant and their relationship to inflammation in patients with multiple myeloma.	25248883
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	After autologous stem cell transplant (AuSCT), patients with multiple myeloma (MM) may receive lenalidomide maintenance therapy.	25248883
Hypoxia	Stem Cell Exhaustion	TRIM62 loss was associated with altered expression of proteins involved in leukemia stem cell homeostasis (b-catenin and Notch), cell motility, and adhesion (integrin-b3, ras-related C3 botulinum toxin substrate [RAC], and fibronectin), hypoxia (Hypoxia-inducible factor 1-alpha [HIF1a], egl-9 family hypoxia-inducible factor 1 [Egln1], and glucose-regulated protein, 78 kDa [GRP78]), and apoptosis (B-cell lymphoma-extra large (BclXL) and caspase 9).	25248926
Diabetes, Metabolic Diseases	Stem Cell Exhaustion	Hyperglycaemic milieu as well as other metabolic disorders linked to diabetes may have an influence on endogenous stem cell properties.	25251698
diabetic	Stem Cell Exhaustion	The present study investigated the feasibility of autologous stem cell therapy in diabetic patients.	25251698
Diabetes	Stem Cell Exhaustion	Adipose tissue is an abundant source of autologous adult stem cells that may bring new therapeutic perspectives on the treatment of diabetes and its complications.	25251698
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Aldehyde dehydrogenase 1 family member A1 (ALDH1A1) is a cancer stem cell marker, and its expression correlates with prognosis in a number of malignancies.	25253129
Virus Diseases, Memory	Stem Cell Exhaustion	T(SCM) constitute a recently identified lymphocyte subset with stem cell-like qualities, including the ability to generate other memory T cell subtypes, and are therefore likely to play an important role in controlling viral infection.	25253339
Healthcare Encounters Domain	Stem Cell Exhaustion	In HO, mesenchymal stem cells (MSCs) are inappropriately activated to undergo osteogenic differentiation.	25253675
Osteoporosis	Stem Cell Exhaustion	Bone marrow-derived mesenchymal stem cells (BMMSCs) from the patients suffering from age-related osteoporosis were found to have numerous degeneration, such as decreased growth rate, impaired capacity of differentiating into local tissue, and repressed telomerase activity.	25257163
Extramedullary Plasmacytoma, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The prognostic impact of extramedullary plasmacytomas (EMPs) on newly diagnosed symptomatic multiple myeloma (MM) was evaluated in the context of treatment approach including autologous stem cell transplantation (ASCT) and chemotherapy alone.	25257340
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Prognostic implication of gene mutations on overall survival in the adult acute myeloid leukemia patients receiving or not receiving allogeneic hematopoietic stem cell transplantations.	25260824
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic stem cell transplantation for patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) has been performed primarily with an HLA-matched donor.	25263628
Cessation of life	Stem Cell Exhaustion	Risk factor for death in hematopoietic stem cell transplantation: are biomarkers useful to foresee the prognosis in this population of patients?	25263811
Pregnancy Complications, Infectious	Stem Cell Exhaustion	The morbidity and mortality in hematopoietic stem cell transplantation (HSCT) occur due to infectious complications and constitute the major clinical problems in HSCT recipients.	25263811
Myeloma cell	Stem Cell Exhaustion	Among plasma cell myeloma (PCM) patients, gene expression profiling (GEP)-based molecular classification has proven to be an independent predictor of survival, after autologous stem cell transplantation.	25265432
Toxic effect	Stem Cell Exhaustion	We anticipate that such an approach might allow patients with high-risk immunoprofiles to be considered for other potential novel therapeutic agents, potentially sparing some patients the toxicity of stem cell transplant.	25265432
Degenerative polyarthritis	Stem Cell Exhaustion	Thus CD146 might be a new cell surface marker for cartilage progenitor cell population in the late-stage osteoarthritis.	25266708
Multiple Myeloma, Hypertension, CTCAE	Stem Cell Exhaustion	A 62 year-old Caucasian man with hypertension and a 4-year history of multiple myeloma, had been previously treated with lenalidomide, bortezomib and two autologous hematopoietic stem cell transplants.	25267524
Kidney Failure, Acute, Septic Shock	Stem Cell Exhaustion	After the second hematopoietic stem cell transplant, he developed acute kidney injury secondary to septic shock and required dialysis for 4 weeks.	25267524
Multiple Myeloma	Stem Cell Exhaustion	Seventeen months after the second hematopoietic stem cell transplant, he was initiated on carfilzomib for relapse of multiple myeloma.	25267524
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Randomized comparison of gemcitabine, dexamethasone, and cisplatin versus dexamethasone, cytarabine, and cisplatin chemotherapy before autologous stem-cell transplantation for relapsed and refractory aggressive lymphomas: NCIC-CTG LY.12.	25267740
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	For patients with relapsed or refractory aggressive lymphoma, we hypothesized that gemcitabine-based therapy before autologous stem-cell transplantation (ASCT) is as effective as and less toxic than standard treatment.	25267740
Childhood Breast Carcinoma	Stem Cell Exhaustion	Estrogen receptor, progesterone receptor, interleukin-6 and interleukin-8 are variable in breast cancer and benign stem/progenitor cell populations.	25269750
Childhood Breast Carcinoma, Neoplasms	Stem Cell Exhaustion	Breast cancer stem/progenitor cells (BCSCs) initiate tumors, but expression of estrogen (ER) or progesterone receptors (PR) and response to tamoxifen is unknown.	25269750
Neoplasms	Stem Cell Exhaustion	On average, BCSCs expressed 10-106 fold less ERa mRNA and 10-103 fold more ERb than tumors or benign stem/progenitor cells (SC).	25269750
Liver carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Regulatory MiR-148a-ACVR1/BMP circuit defines a cancer stem cell-like aggressive subtype of hepatocellular carcinoma.	25271001
Specialty Type - cancer	Stem Cell Exhaustion	The subtype characterized by a cancer stem cell-like signature was clinically aggressive and associated with poor survival.	25271001
Hollings Cancer Center	Stem Cell Exhaustion	We identified a clinically aggressive stem cell-like subtype of HCC that is characterized by an miR-148a-ACVR1-BMP-Wnt circuit.	25271001
Gastrointestinal mucositis	Stem Cell Exhaustion	Oral mucositis is a chief complication in patients undergoing hematopoietic stem cell transplantation (HSCT).	25271965
Multiple Myeloma	Stem Cell Exhaustion	18 FDG-PET/CT for prognostic stratification of patients with multiple myeloma relapse after stem cell transplantation.	25277179
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The aim of this study was to investigate the prognostic value of 18F-fluoro-deoxyglucose positron emission tomography-computed tomography (18F-FDG-PET/CT) in 37 patients with a history of multiple myeloma (MM) and suspected or confirmed recurrence after stem cell transplantation (SCT).	25277179
Adenocarcinoma of pancreas	Stem Cell Exhaustion	The hedgehog (HH) signaling pathway is a key regulator in tumorigenesis of pancreatic adenocarcinoma and is upregulated in pancreatic adenocarcinoma cancer stem cells (CSCs).	25278454
Multiple Myeloma	Stem Cell Exhaustion	Efficacy of vinorelbine plus granulocyte colony-stimulation factor for CD34+ hematopoietic progenitor cell mobilization in patients with multiple myeloma.	25278456
Multiple Myeloma	Stem Cell Exhaustion	We aimed to assess the efficacy of vinorelbine plus granulocyte colony-stimulating factor (G-CSF) for chemo-mobilization of CD34(+) hematopoietic progenitor cells (HPC) in patients with multiple myeloma and to identify adverse risk factors for successful mobilization.	25278456
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	The BORIS-positive cells isolated using BORIS-molecular beacon, expressed higher telomerase hTERT, stem cell (NANOG, OCT4, SOX2) and cancer stem cell marker genes (CD44 and ALDH1) compared to the BORIS-negative tumor cells.	25279549
Avascular Necrosis, CTCAE	Stem Cell Exhaustion	Complete resolution of avascular necrosis of the human femoral head treated with adipose tissue-derived stem cells and platelet-rich plasma.	25281062
Avascular necrosis, Avascular Necrosis, CTCAE	Stem Cell Exhaustion	We report a case of a 43-year-old man with early stage (stage 1) avascular necrosis (AVN) of the femoral head treated with adipose tissue-derived stem cells (ASCs) and platelet-rich plasma (PRP).	25281062
Glioma, Specialty Type - cancer	Stem Cell Exhaustion	The prognostic value of clinical factors and cancer stem cell-related markers in gliomas.	25283629
Glioblastoma Multiforme Pathway, Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	The same characteristics were identified in cancer cells, and recently a major part of the glioma research has focused on the cancer stem cell (CSC) hypothesis, suggesting that only CSCs posses the ability of initiating new tumours.	25283629
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Treatment of MDS comprised allogeneic stem cell transplant in eight patients (median survival, 219 days; one patient alive at 624 days) and a hypomethylating agent in 21 patients (response of stable or better in five patients).	25284489
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	We sought to determine whether the more intensive salvage chemotherapy approach used in Southern Alberta (SAB) compared to the conventional dose salvage approach used in Northern Alberta (NAB) affects the rates of autologous stem cell transplant (ASCT) and survival in patients with relapsed DLBCL.	25284495
Muscle, Smooth, Vascular	Stem Cell Exhaustion	Here, we leverage human pluripotent stem cells to generate vascular smooth muscle cells (SMCs) from neural crest progenitors, recapitulating brain-vasculature-specific attributes of Ab metabolism.	25284792
Neoplasms	Stem Cell Exhaustion	These tumours have a polyphenotypic immunophentype that favours a derivation from uterine mesenchymal stem cells.	25291872
Multiple Myeloma	Stem Cell Exhaustion	Cyclophosphamide-based hematopoietic stem cell mobilization before autologous stem cell transplantation in newly diagnosed multiple myeloma.	25293363
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	High-dose cyclophosphamide (Cy) is frequently employed for peripheral blood mobilization of hematopoietic stem cells before high-dose chemotherapy with autologous stem cell transplantation (ASCT) in multiple myeloma (MM).	25293363
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Live birth after single embryo transfer of autologous cryopreserved oocytes from a patient with myelodysplastic syndrome who underwent allogenic peripheral blood stem cell transplantation.	25294099
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We report a live birth after single embryo transfer derived from autologous cryopreserved oocytes of a patient with myelodysplastic syndrome who had undergone allogenic peripheral blood stem cell transplantation (PBSCT).	25294099
Extramedullary	Stem Cell Exhaustion	Clinical and pathologic analysis of extramedullary tumors after hematopoietic stem cell transplantation.	25294373
Extramedullary	Stem Cell Exhaustion	Clinical and pathologic analyses of 41 extramedullary biopsy/resection specimens of extramedullary tumors (EMTs) after hematopoietic stem cell transplantation (HSCT) were performed.	25294373
Specialty Type - cancer, Lymphoma, Multiple Myeloma, leukemia	Stem Cell Exhaustion	Between September 2013 and January 2014, 20 hematologic oncologists from the Dana-Farber/Harvard Cancer Center participated in four focus groups regarding EOL care for leukemia, lymphoma, multiple myeloma, and hematopoietic stem-cell transplantation.	25294393
Childhood Breast Carcinoma	Stem Cell Exhaustion	Activation of the Hippo transducer TAZ is emerging as a novel oncogenic route in breast cancer and it has been associated with breast cancer stem cells.	25294813
Hypertensive (finding)	Stem Cell Exhaustion	Quantitative and functional characteristics of endothelial progenitor cells in newly diagnosed hypertensive patients.	25296717
Fatigue, Depression, CTCAE, Anxiety Disorders	Stem Cell Exhaustion	Health-related quality of life (HRQoL) is often substantially reduced among individuals who have undergone hematopoietic stem cell transplantation (HSCT), and incidences of depression, fatigue, and anxiety are elevated.	25297466
Chronic granulomatous disease	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplant for high-risk adult patients with chronic granulomatous disease: first case report from Iran.	25299376
Chronic granulomatous disease	Stem Cell Exhaustion	We describe the successful hematopoietic stem cell transplant of a 22-year-old patient with chronic granulomatous disease at our center.	25299376
Chronic granulomatous disease	Stem Cell Exhaustion	Our case was a relatively old male patient compared with other patients having the diagnosis of chronic granulomatous disease who underwent hematopoietic stem cell transplant.	25299376
Graft-vs-Host Disease	Stem Cell Exhaustion	At the time of this writing, the patient is alive and well with no serious complication and without any evidence of graft-versus-host disease or rejection 12 months after stem cell transplant.	25299376
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Influence of insulin and glargine on outgrowth and number of circulating endothelial progenitor cells in type 2 diabetes patients: a partially double-blind, randomized, three-arm unicenter study.	25300286
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A well-tolerated regimen of 800 cGy TBI-fludarabine-busulfan-ATG for reliable engraftment after unmanipulated haploidentical peripheral blood stem cell transplantation in adult patients with acute myeloid leukemia.	25300871
peripheral blood, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Eighty adult patients with acute myeloid leukemia (AML) received peripheral blood T cell-replete HLA haploidentical hematopoietic stem cell transplantation (haplo-HSCT).	25300871
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We suggest the strategy of fractionated 800 cGy TBI-based conditioning with unmanipulated peripheral blood stem cell grafts seems feasible with favorable outcomes for adult patients with AML undergoing haplo-HSCT in CR.	25300871
Myeloid Leukemia, Chronic, B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1, BCR gene	Stem Cell Exhaustion	Despite the successes of tyrosine kinase inhibitors (TKIs) in improving outcomes in patients with chronic myeloid leukemia (CML) and Philadelphia-positive acute lymphoblastic leukemia (Ph + ALL), allogeneic hematopoietic stem cell transplantation (HSCT) continues to be an important and potentially curative option for selected patients with either disease.	25300870
Sex Characteristics	Stem Cell Exhaustion	Sexual dimorphism in epigenomic responses of stem cells to extreme fetal growth.	25300954
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Haploidentical peripheral blood stem cell infusion in combination with chemotherapy for acute myeloid leukaemia in elderly patients.	25302724
Toxic effect, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Two elderly AML patients treated with infusion of family-derived partially human leukocyte antigen (HLA)-matched peripheral blood stem cells following each cycle of chemotherapy entered morphological complete remission without graft versus host disease or major toxicity.	25302724
Multiple Myeloma	Stem Cell Exhaustion	Thalidomide-prednisone maintenance following autologous stem cell transplant for multiple myeloma: effect on thrombin generation and procoagulant markers in NCIC CTG MY.10.	25302852
Specialty Type - cancer, vinyltriethoxysilane	Stem Cell Exhaustion	The National Cancer Institute of Canada Clinical Trials Group MY.10 phase III clinical trial compared thalidomide-prednisone to observation for 332 patients with MM post-autologous stem cell transplantation (ASCT), with a primary endpoint of overall survival and various secondary endpoints including the incidence of VTE.	25302852
Secondary Neoplasm	Stem Cell Exhaustion	Moreover, epithelial-mesenchymal transition (EMT) and stem cell features are major mechanisms for metastasis.	25303055
Childhood Breast Carcinoma	Stem Cell Exhaustion	Using a triple fluorescence technique, the expression of EMT (N-cadherin) and stem cell markers (CD133) was analyzed in CTCs detected via cytokeratin in blood samples from 26 metastatic breast cancer patients.	25303055
Kidney Failure, Chronic, Rheumatoid Arthritis, HIV Infections, Immunocompromised Host	Stem Cell Exhaustion	Immunocompromised patients with HIV infection, chronic renal failure, rheumatoid arthritis, solid-organ or stem-cell transplantation, and healthy control subjects were evaluated head-to-head by the TST, QuantiFERON-TB-Gold in-tube test (ELISA), and T-SPOT.TB test (enzyme-linked immunospot) at 17 centers in 11 European countries.	25303140
Kidney Failure, Chronic, Rheumatoid Arthritis, HIV Infections	Stem Cell Exhaustion	Frequencies of positive test results varied from 8.7 to 15.9% in HIV infection (n = 768), 25.3 to 30.6% in chronic renal failure (n = 270), 25.0% to 37.2% in rheumatoid arthritis (n = 199), 9.0 to 20.0% in solid-organ transplant recipients (n = 197), 0% to 5.8% in stem-cell transplant recipients (n = 103), and 11.2 to 15.2% in immunocompetent control subjects (n = 211).	25303140
Ischemia, Diabetic Foot	Stem Cell Exhaustion	Comparison of the effect of stem cell therapy and percutaneous transluminal angioplasty on diabetic foot disease in patients with critical limb ischemia.	25304666
CLU protein, human, Ischemia, Diabetic Foot	Stem Cell Exhaustion	The aim of our study was to compare the effect of autologous stem cell therapy (SCT) and percutaneous transluminal angioplasty (PTA) on diabetic foot disease (DFD) in patients with critical limb ischemia (CLI).	25304666
CLU protein, human	Stem Cell Exhaustion	Thirty-one patients with DFD and CLI treated by autologous stem cells and 30 patients treated by PTA were included in the study; 23 patients with the same inclusion criteria who could not undergo PTA or SCT formed the control group.	25304666
Ischemic stroke	Stem Cell Exhaustion	Reparative therapy for acute ischemic stroke with allogeneic mesenchymal stem cells from adipose tissue: a safety assessment: a phase II randomized, double-blind, placebo-controlled, single-center, pilot clinical trial.	25304723
Cerebrovascular accident	Stem Cell Exhaustion	Few studies have evaluated the possible beneficial effect of the administration of stem cells in the early stages of stroke.	25304723
Acute Cerebrovascular Accidents	Stem Cell Exhaustion	Intravenous administration of allogeneic mesenchymal stem cells (MSCs) from adipose tissue in patients with acute stroke could be a safe therapy for promoting neurovascular unit repair, consequently supporting better functional recovery.	25304723
Blood Vessel	Stem Cell Exhaustion	This was measured by prevalence of endothelial progenitor cells (EPCs), which are bone marrow-derived cells that home preferentially to sites of vascular damage.	25306212
Bacterial Infections	Stem Cell Exhaustion	In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.	25307862
Neoplasms	Stem Cell Exhaustion	We cultured cells from healthy gastric tissues, single-sorted stem cells, or tumor tissues.	25307862
NTRK1 wt Allele	Stem Cell Exhaustion	The most widely accepted hypotheses considering co-occurrence of MTC and PTC are stem cell theory, collision effect theory and hostage theory.	25308015
Neoplasms	Stem Cell Exhaustion	In conclusion, co-expression of thyroglobulin, synaptophysin and chromogranin by the papillary component of mixed tumor seems to support stem cell theory in our first case, whereas positive staining for calcitonin but not for thyroglobulin in the medullary component of the tumor along with separation of these two tumors from each other by a normal thyroid tissue seem to indicates the likelihood of collision effect theory in our second case.	25308015
Malignant Neoplasms	Stem Cell Exhaustion	Results In total, 73% of patients had high-grade malignancy, 47.6% received intensive chemotherapy before admission, and 30% underwent hematologic stem cell transplantation procedure.	25310461
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The explosion of new knowledge regarding the AML genome has yet to be translated into therapeutic benefit, but analysis of specific molecular features in AML samples has enabled the field to more accurately parse out prognosis and assign appropriate therapies (eg, chemotherapy vs allogeneic stem cell transplantation) for groups of patients.	25311744
Hypertrophy	Stem Cell Exhaustion	More specifically, we focused on the myogenic stem cell population, the satellite cell (SC) as a potential mediator of hypertrophy.	25313863
Hematological Disease	Stem Cell Exhaustion	In 2008-2012, the Hematology Research Center, Ministry of Health of the Russian Federation, examined 203 patients with blood system diseases who needed allogeneic hematopoietic stem cell transplantation (allo-HSCT) and their 386 blood relatives.	25314775
Hematological Disease	Stem Cell Exhaustion	These registries increase the chance to find a HLA-compatible unrelated donor for a short time for a patient with blood disease who has an indication for hematopoietic stem cell transplantation.	25314775
Degenerative polyarthritis	Stem Cell Exhaustion	Our results suggested that the interaction between OACs and ADSCs is highly dependent on cell distribution in 3D and soluble factors, which should be taken into consideration when designing stem cell-based therapy for treating OA patients.	25315023
Cartilage Diseases, Degenerative polyarthritis	Stem Cell Exhaustion	Stem cells hold great promise for treating cartilage degenerative diseases such as osteoarthritis (OA).	25315023
NGFR gene	Stem Cell Exhaustion	In addition, tomato feeding significantly reduced expression of genes associated with stem cell features, Aldh1a and Ly6a, whereas lycopene feeding significantly reduced expression of neuroendocrine differentiation-related genes, Ngfr and Syp.	25315431
Prostate carcinoma	Stem Cell Exhaustion	Future studies on androgen signaling/metabolism, stem cell features, and neuroendocrine differentiation pathways may elucidate the mechanisms by which dietary tomato and lycopene impact prostate cancer risk.	25315431
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Patients >=aged 60 years with relapsed/refractory DLBCL, not candidates for autologous stem cell transplantation, were treated R-CVEP [R 375 mg/m(2) intravenously (IV), day 1; C 600 mg/m(2) IV days 1, 8: E 70 mg/m(2) IV day 1, 140 mg/m(2) days 2, 3 orally (PO); V (300 vs. 400 mg) PO and P 60 mg/m(2) PO days 1-10] every 28 d for six cycles.	25316653
TSPYL2 gene, Primary cutaneous lymphoma	Stem Cell Exhaustion	Brentuximab is a well-tolerated, promising new treatment option for advanced CTCL that can be integrated in an allogeneic stem cell transplantation plan by selectively depleting malignant CD30+ cutaneous lymphoma cells.	25317818
Lymphoproliferative Disorders	Stem Cell Exhaustion	Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disorder (EBV-PTLD) is a complication of hematopoietic stem cell transplantation (HSCT).	25318948
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Poor general health was associated with acute graft-versus-host disease (GVHD), low self-efficacy, and cord blood stem cells.	25322970
Cessation of life, Coronary Arteriosclerosis	Stem Cell Exhaustion	Reduced circulating progenitor cell counts, identified primarily as CD34(+) mononuclear cells or its subset expressing CD133, are associated with risk of death in individuals with coronary artery disease, suggesting that impaired endogenous regenerative capacity is associated with increased mortality.	25323857
Coronary Arteriosclerosis	Stem Cell Exhaustion	Circulating CD34+ progenitor cells and risk of mortality in a population with coronary artery disease.	25323857
Neoplasms	Stem Cell Exhaustion	A phase I dose escalation and expansion study of the anticancer stem cell agent demcizumab (anti-DLL4) in patients with previously treated solid tumors.	25324140
Systemic Scleroderma	Stem Cell Exhaustion	Autologous stem cell transplantation in a patient with severe systemic sclerosis.	25326407
Specialty Type - cancer	Stem Cell Exhaustion	The Cancer Genome Atlas (TCGA) provides a unique resource for comprehensive discovery of mutations and genes in blood that may contribute to the clonal expansion of hematopoietic stem/progenitor cells.	25326804
Anthracycline Antibiotics	Stem Cell Exhaustion	First-line anthracycline-based chemotherapy significantly improved time-to-next-treatment even in patients receiving salvage autologs stem cell transplantation (P = 0.041).	25327841
Hypertension, CTCAE, Ventricular hypertrophy	Stem Cell Exhaustion	Increased mobilization of mesenchymal stem cells in patients with essential hypertension: the effect of left ventricular hypertrophy.	25329239
Cardiovascular Diseases	Stem Cell Exhaustion	Stem cells have great clinical significance in many cardiovascular diseases.	25329239
Hypertension, CTCAE	Stem Cell Exhaustion	However, there are limited data regarding the involvement of mesenchymal stem cells (MSCs) in the pathophysiology of arterial hypertension.	25329239
Atherosclerosis, Retinal Neovascularization, Reperfusion Injury	Stem Cell Exhaustion	Longevinex(r) (L/RV) is a low dose hormetic over-the-counter (OTC) oral resveratrol (RV) based matrix of red wine solids, vitamin D3 and inositol hexaphosphate (IP6) with established bioavailability, safety, and short-term efficacy against the earliest signs of human atherosclerosis, murine cardiac reperfusion injury, clinical retinal neovascularization, and stem cell survival.	25329968
Lymphoma, Multiple Myeloma, Acute leukemia	Stem Cell Exhaustion	A single-center, prospective, non-randomized clinical study was performed to examine the safety and feasibility of early discharge in patients undergoing consolidation chemotherapy for acute leukemia, or autologous stem cell transplant for lymphoma or multiple myeloma.	25330445
Neoplasms, Cytogenetic Complete Response	Stem Cell Exhaustion	In order to identify other CRC stem cell-specific genes, we performed a comparative expression profiling of CD133(+) and CD133(-) cell populations in primary and metastatic tumors from four patients with CRC.	25331798
Colorectal Carcinoma	Stem Cell Exhaustion	Transcriptome analysis of CD133-positive stem cells and prognostic value of survivin in colorectal cancer.	25331798
Colorectal Carcinoma, Cytogenetic Complete Response	Stem Cell Exhaustion	CD133 is an important, but not exclusive, biomarker of colorectal cancer (CRC) stem cells.	25331798
Cytogenetic Complete Response	Stem Cell Exhaustion	Our data suggest that CD133(+) CRC stem cells have a distinct expression pattern and that survivin, up-regulated by differentially expressed IL-4, is a candidate biomarker for the prediction of recurrence and survival in CRC.	25331798
Corneal Endothelial Cell Loss	Stem Cell Exhaustion	Emerging cellular markers of endothelial damage and repair include endothelial microparticles (EMPs) and endothelial progenitor cells (EPCs), respectively.	25332321
Hollings Cancer Center	Stem Cell Exhaustion	The therapeutic value of GPx3 for HCC was further investigated using human induced pluripotent stem cell derived mesenchymal stem cells (hiPSC-MSCs) as its delivery vehicle.	25333265
Cerebrovascular accident	Stem Cell Exhaustion	Stem cell therapy is an emerging therapeutic modality in the treatment of stroke.	25333752
Fever	Stem Cell Exhaustion	The most common side effect of stem cell transplantation in these six cases was low fever that usually lasted 2-4 days after each therapy.	25333752
Ischemic stroke	Stem Cell Exhaustion	A two-year follow-up study of cotransplantation with neural stem/progenitor cells and mesenchymal stromal cells in ischemic stroke patients.	25333752
Ischemic stroke	Stem Cell Exhaustion	We assessed the safety and feasibility of the cotransplantation of neural stem/progenitor cells (NSPCs) and mesenchymal stromal cells (MSCs) in patients with ischemic stroke.	25333752
Chronic Obstructive Airway Disease, Coughing	Stem Cell Exhaustion	[Patient with COPD after allogeneic hematopoietic stem cell transplantation with cough and subfebrile temperature].	25334076
Chronic Obstructive Airway Disease, Coughing	Stem Cell Exhaustion	A 53-year-old male presents with progressive cough and subfebrile temperatures with a history of COPD and post one-year allogeneic hematopoietic stem cell transplantation.	25334076
Malignant neoplasm of lung, Specialty Type - cancer	Stem Cell Exhaustion	Clinical significance of putative cancer stem cell marker CD44 in different histological subtypes of lung cancer.	25335738
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	According to the cancer stem cell theory, tumors originate from a subset of cells known as cancer stem cells (CSCs) that are responsible for tumor initiation, resistance and relapse.	25335738
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Adult patients with acute myeloid leukemia and myelodysplastic syndrome on induction therapy or allogeneic hematopoietic stem cell transplant recipients were randomized (1:1 ratio) to 1 of 2 arms: "GM-PCR group" (the results of serial serum GM and PCR assays were provided to treating physicians) and "GM group" (only the results of serum GM were informed).	25336623
Avascular Necrosis of Femur Head	Stem Cell Exhaustion	[Treatment of non-traumatic femoral head avascular necrosis by perfusion of bone marrow stromal stem cells through optional artery].	25338442
Avascular Necrosis of Femur Head	Stem Cell Exhaustion	To study the medium and long term effects of perfusion of bone marrow stromal stem cells through optional artery for the treatment of non-traumatic femoral head avascular necrosis.	25338442
Avascular Necrosis of Femur Head	Stem Cell Exhaustion	From January 2000 to December 2004,62 cases(78 hips) with non-traumatic femoral head necrosis accepted optional artery marrow stromal stem cells infusion treatment and had complete follow-up data, including 43 hips of 35 males and 35 hips of 27 females with an average age of 36.3 years old (22 to 54).	25338442
Avascular Necrosis of Femur Head, Thickened	Stem Cell Exhaustion	Perfusion of bone marrow stromal stem cells through optional artery can effective treat non-traumatic femoral head necrosis of ARCO I, II period, it can make the femoral circumflex artery and its branches increased thickening.	25338442
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This study was aimed to explore the effect and feasibility of reduced conditioning intensity allogeneic hematopoietic stem cell transplantation (allo-HSCT) in the treatment of relapsed ETO positive acute myeloid leukemia (AML) patients.	25338589
Graft-vs-Host Disease, Toxic effect	Stem Cell Exhaustion	The preventive donor's peripheral blood stem cell infusion were performed after 3 months of transplantation, and the toxicity, GVHD and disease-free survival were observed in patients after transplantation.	25338589
Specialty Type - cancer, Skin Neoplasms	Stem Cell Exhaustion	Co-expression of putative cancer stem cell markers, CD133 and Nestin, in skin tumors.	25339000
Specialty Type - cancer, Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSC) are populations of cells responsible for tumor initiation, progression and therapeutic resistance in many cancers.	25339000
Malignant Neoplasms	Stem Cell Exhaustion	CD133 is one of the most important stem cell markers in solid cancers and Ki-67 is a marker that reflects cell proliferation.	25339008
Chronic Kidney Diseases	Stem Cell Exhaustion	In the present study, we investigated the potential involvement of endothelial microparticles (MPs) and endothelial progenitor cells (EPCs) in the generation of VC in CKD patients.	25339701
Liver Cirrhosis, Hypertension, CTCAE	Stem Cell Exhaustion	[Clinical efficacy of autologous mesenclyme multipotential stem cells transplantation in the liver cirrhosis and portal hypertension treatment].	25341236
Liver Cirrhosis, Hypertension, CTCAE	Stem Cell Exhaustion	In 14 patients with cirrhosis and portal hypertention autologous mesenclyme multipotential stem cells (AMMSC) transplanation was performed in portal vein (I group, n=7) and common trunk of the hepatic artery (II group, n=6).	25341236
Stable chronic Graft vs Host Disease, Dry Eye Syndromes	Stem Cell Exhaustion	These results emphasize the role of aqueous-deficient and evaporative dry eye disease in patients with cGVHD after undergoing allogeneic hematologic stem cell transplantation.	25343699
Toxic effect	Stem Cell Exhaustion	SINV is used as a vector for the delivery of genes into selected neural stem cell lines; however, the toxicity and side effects of this vector have rarely been discussed.	25343994
Cessation of life, Communicable Diseases	Stem Cell Exhaustion	In this context, we investigated the cellular responses of human embryonic stem cell (hESCs) derived neural progenitors (hNPCs) to SINV infection by assessing susceptibility of the cells to SINV infection, analyzing the effect of infection on cell proliferation and cell death, and examining the impact of SINV infection on hNPCs markers of stemness.	25343994
Toxic effect	Stem Cell Exhaustion	On the other hand, the toxicity of SINV to hNPCs cells cannot be ignored, and therefore extra care should be taken when using SINV as a vector to deliver genes into human stem cell lines.	25343994
Radiation injury of bone marrow	Stem Cell Exhaustion	Maitake mushroom beta-glucan, a dietary supplement, stimulates hematopoietic progenitor cell differentiation, granulocyte colony-stimulating factor production, and recovery of peripheral blood leukocytes after bone marrow injury.	25351719
Hair follicle structure	Stem Cell Exhaustion	Spiradenoma and cylindroma originate from the hair follicle bulge and not from the eccrine sweat gland: an immunohistochemical study with CD200 and other stem cell markers.	25354097
Neoplasms	Stem Cell Exhaustion	Follicular stem cell markers may allow for further characterization of these neoplasms.	25354097
Neoplasms	Stem Cell Exhaustion	A total of 97 tumors were examined for the expression pattern of follicular stem cell markers cytokeratin 15 (CK15), cytokeratin 19 (CK19), pleckstrin homology-like domain, family A, member 1 (PHLDA1), and CD200.	25354097
Lymphoma	Stem Cell Exhaustion	Intermediate doses of cytarabine plus granulocyte-colony-stimulating factor as an effective and safe regimen for hematopoietic stem cell collection in lymphoma patients with prior mobilization failure.	25354577
Lymphoma	Stem Cell Exhaustion	High-dose chemotherapy supported by autologous stem cell transplantation (ASCT) is an effective treatment for patients with lymphomas.	25354577
Failure	Stem Cell Exhaustion	However, failure to reach the minimum threshold of hematopoietic stem cells to proceed to ASCT may occur, even with the most effective strategies currently available.	25354577
Specialty Type - cancer, Glioblastoma	Stem Cell Exhaustion	As Cancer stem cell (CSC) plays a pivotal role in the resistance to conventional cancer therapy, we explored the effects of MSC500 on the CSC-like side population (SP) in GBM8401 human glioblastoma multiforme cells.	25359730
Specialty Type - cancer, Glioblastoma	Stem Cell Exhaustion	Metformin exposure induces antiproliferative effects in cancer stem cell-enriched cultures, isolated from three individual WHO grade IV human glioblastomas.	25361004
Failure, Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	The lack of drugs affecting cancer stem cell viability is the main cause of therapy failure and tumor relapse.	25361004
Adult Glioblastoma	Stem Cell Exhaustion	Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current.	25361004
Adult Glioblastoma	Stem Cell Exhaustion	Metformin inhibition of CLIC1 activity induces G1 arrest of glioblastoma stem cells.	25361004
Adult Glioblastoma	Stem Cell Exhaustion	We identified CLIC1 not only as a modulator of cell cycle progression in human glioblastoma stem cells but also as the main target of metformin's antiproliferative activity, paving the way for novel and needed pharmacological approaches to glioblastoma treatment.	25361004
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Down-regulation of Dicer1 promotes cellular senescence and decreases the differentiation and stem cell-supporting capacities of mesenchymal stromal cells in patients with myelodysplastic syndrome.	25361944
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Collectively, the results of our study show that mesenchymal stromal cells from patients with myelodysplastic syndrome are prone to senescence and that Dicer1 down-regulation promotes cellular senescence and decreases the differentiation and stem cell-supporting capacities of mesenchymal stromal cells.	25361944
Neoplasms	Stem Cell Exhaustion	Bromodomain PHD-finger transcription factor (BPTF) could regulate embrogenesis and stem cell differentiation, and it may be involved in tumor progression and EMT.	25362514
Cerebral Hemorrhage	Stem Cell Exhaustion	In this study, we aimed to explore the curative effect and safety of neural stem cell intrathecal transplantation for the treatment of cerebral hemorrhage.	25366723
Cerebral Hemorrhage	Stem Cell Exhaustion	Curative effect and safety of intrathecal transplantation of neural stem cells for the treatment of cerebral hemorrhage.	25366723
Cerebral Hemorrhage	Stem Cell Exhaustion	We transplanted 4.0 x 10(8) neural stem cells per procedure into the subarachnoid space by lumbar puncture 7 days after cerebral hemorrhage, twice a week, a total of 4 times.	25366723
Cerebral Hemorrhage	Stem Cell Exhaustion	Our data suggest that the use of neural stem cells in intrathecal transplantation for the treatment of cerebral hemorrhage is safe and effective.	25366723
Febrile Neutropenia	Stem Cell Exhaustion	Neutropenic fever following hematologic stem cell transplantation was found in three cases.	25367410
Hematologic Neoplasms	Stem Cell Exhaustion	Angiopoietins in haematopoietic stem cell mobilisation in patients with haematological malignancies.	25369606
Multiple Myeloma	Stem Cell Exhaustion	Evaluation of risk of symptomatic cytomegalovirus reactivation in myeloma patients treated with tandem autologous stem cell transplantation and novel agents: a single-institution study.	25369809
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Our data are consistent with the recent finding of preleukaemic stem cells in AML, which are resistant to chemotherapy.	25371149
leukemia	Stem Cell Exhaustion	Incidence, risk factors and clinical outcome of leukemia relapses with loss of the mismatched HLA after partially incompatible hematopoietic stem cell transplantation.	25371177
leukemia	Stem Cell Exhaustion	Genomic loss of the mismatched human leukocyte antigen (HLA) is a recently described mechanism of leukemia immune escape and relapse after allogeneic hematopoietic stem cell transplantation (HSCT).	25371177
Malignant tumor of colon	Stem Cell Exhaustion	Ascl2, a basic helix-loop-helix transcription factor, is a downstream target of WNT signaling that controls the fate of intestinal cryptic stem cells and colon cancer progenitor cells.	25371200
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Nocardia asteroides subretinal abscess in patient with acute myelogenous leukemia after allogeneic stem cell transplant.	25372323
Deteriorating vision, Abscess	Stem Cell Exhaustion	A 40-year-old man with a history of allogeneic stem cell transplant presents with decreased vision and a macular subretinal abscess.	25372323
Lymphoma, Follicular	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation for relapsed follicular lymphoma: safety profile and clinical outcome in a single-center experience.	25373321
Lymphoma, Follicular	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation (AHSCT) is a treatment option for relapsed and recurrent follicular lymphoma (R/R FL); however, its value in the rituximab era remains to be elucidated.	25373321
PAFAH1B1 wt Allele, leukemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	A retrospective single-center analysis was performed on patients with leukemia or myelodysplastic syndrome (MDS), aged <=20 years, who had received an 8-Gy TBI/FLU/CY RTMAC regimen followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT).	25373730
Malignant neoplasm of urinary bladder	Stem Cell Exhaustion	A recent genome wide association study (GWAS) identified an association between the rs2294008 polymorphism of the prostate stem cell antigen (PSCA) gene and bladder cancer risk in Caucasians.	25374226
Immunocompromised Host	Stem Cell Exhaustion	Human adenoviruses (HAdV) are important viral pathogens recognized increasingly in immunocompromised hosts, especially in allogeneic haematopoietic stem cell transplant recipients (alloHSCT).	25376263
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic stem cell transplantation (SCT) provides the best mechanism of preventing relapse in acute myeloid leukaemia (AML).	25376374
Ischemic stroke	Stem Cell Exhaustion	Intravenous autologous bone marrow mononuclear stem cell therapy for ischemic stroke: a multicentric, randomized trial.	25378424
Cerebrovascular accident	Stem Cell Exhaustion	Pilot studies have suggested benefit from intravenous administration of bone marrow mononuclear stem cells (BMSCs) in stroke.	25378424
Malignant neoplasm of stomach	Stem Cell Exhaustion	Comparative proteomics analysis of gastric cancer stem cells.	25379943
Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	Cancer stem cells (CSCs) are responsible for cancer progression, metastasis, and recurrence.	25379943
Specialty Type - cancer	Stem Cell Exhaustion	The stem cell factor (SCF) receptor CD117 (c-kit), is widely used for identification of hematopoietic stem cells and cancer stem cells.	25380303
FAP protein, human, Neoplasms	Stem Cell Exhaustion	The CD117 positive fibroblast-like stromal cells were all positive for mesenchymal stem/stromal cell (MSC) marker CD73 but negative for fibroblast markers fibroblast activation protein (FAP) and a smooth muscle actin (a-SMA), indicating that the CD117+/CD73+ fibroblast-like stromal cells are a subtype of mesenchymal stem cells in tumor stroma, although further characterization of these cells are needed.	25380303
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Contribution of non-infectious transplantation-related complications to the outcome of hematopoietic stem cell transplantation in patients with acute myeloid leukemia: a single institute analysis.	25380682
Primary amyloidosis	Stem Cell Exhaustion	High-dose melphalan and autologous hematopoietic stem cell transplantation in primary amyloidosis: single-center results.	25380940
Malignant neoplasm of stomach, Specialty Type - cancer	Stem Cell Exhaustion	Overexpression of NRG1 promotes progression of gastric cancer by regulating the self-renewal of cancer stem cells.	25381017
Malignant neoplasm of stomach	Stem Cell Exhaustion	Gastric cancer stem cells (GCSCs) have been successfully isolated from patients.	25381017
Adult Glioblastoma	Stem Cell Exhaustion	Identification of OLIG2 as the most specific glioblastoma stem cell marker starting from comparative analysis of data from similar DNA chip microarray platforms.	25384509
Glioblastoma Multiforme Pathway, Specialty Type - cancer	Stem Cell Exhaustion	The cancer stem cell concept suggests that a rare stem cell population, called glioma stem cells (GSCs), has high ability to self-renewal leading to recurrence in GBM.	25384509
Thrombotic Microangiopathies	Stem Cell Exhaustion	Fragmented Red Cell as a Possible Favorable Prognostic Marker of Hematopoietic Stem Cell Transplantation Associated Thrombotic Microangiopathy.	25385174
Thrombotic Microangiopathies	Stem Cell Exhaustion	In this study, it is noted that FRC might be a favorable prognostic marker of hematopoietic stem cell transplantation associated thrombotic microangiopathy (TA-TMA).	25385174
Chronic heart failure, ventricular mass	Stem Cell Exhaustion	Left ventricular mass and progenitor cells in chronic heart failure patients.	25387824
Chronic heart failure	Stem Cell Exhaustion	The aim of the study was to evaluate the association between circulating (CPCs) and endothelial (EPCs) progenitor cells and left ventricular (LV) remodeling in chronic heart failure (HF).	25387824
B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Phase 1/2 study of nilotinib prophylaxis after allogeneic stem cell transplantation in patients with advanced chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia.	25387866
Myeloid Leukemia, Chronic, B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1, BCR gene	Stem Cell Exhaustion	Allogeneic stem cell transplantation (SCT) remains the standard treatment for advanced chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL).	25387866
TFE3 Positive	Stem Cell Exhaustion	Loss of microphthalmia-associated transcription factor-positive root sheath cells was seen, suggestive of loss of melanocyte stem cells.	25388912
Encephalitis, Acute lymphocytic leukemia	Stem Cell Exhaustion	Proven Epstein-Barr encephalitis with negative EBV-DNA load in cerebrospinal fluid after allogeneic hematopoietic stem cell transplantation in a child with acute lymphoblastic leukemia.	25388950
Atherosclerosis	Stem Cell Exhaustion	Mesenchymal stem cells alleviate atherosclerosis by elevating number and function of CD4(+)CD25 (+)FOXP3 (+) regulatory T-cells and inhibiting macrophage foam cell formation.	25389006
Plaque, Atherosclerotic	Stem Cell Exhaustion	Here, we studied the effect of bone marrow-derived mesenchymal stem cells (BM-MSCs) on atherosclerotic plaque formation in Apolipoprotein E(-/-) (ApoE-KO) mice, and elucidated the underlying mechanism.	25389006
Parkinson Disease	Stem Cell Exhaustion	Here, we investigated if induced pluripotent stem cell-derived neuronal precursor cells (NPCs) from a patient with Parkinson's disease carrying a genomic triplication of the SNCA gene (SNCA-Tri).	25390032
palladium	Stem Cell Exhaustion	The observation of this "stem cell pathology" could have a great impact on both quality and quantity of neuronal networks and could provide a powerful new tool for development of neuroprotective strategies for PD.	25390032
palladium	Stem Cell Exhaustion	The impact of altered a-synuclein protein expression on integrity and developmental potential of neuronal stem cells is largely unexplored, but may have wide ranging implications for PD manifestation and disease progression.	25390032
ELN wt Allele	Stem Cell Exhaustion	Recent studies have revealed that cells from WS patients can be successfully reprogrammed into induced pluripotent stem cells (iPSCs).	25390333
Osteosarcoma, Specialty Type - cancer	Stem Cell Exhaustion	Bone morphogenetic protein-2 (BMP-2) plays important roles in the development of bone and cartilage and in inhibiting the tumorigenicity of cancer stem cells in human osteosarcoma cell line.	25391427
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Upfront allogeneic stem-cell transplantation for patients with nonlocalized untreated peripheral T-cell lymphoma: an intention-to-treat analysis from a single center.	25392158
Bulbo-Spinal Atrophy, X-Linked	Stem Cell Exhaustion	Human adipose-derived mesenchymal stem cells as a new model of spinal and bulbar muscular atrophy.	25392924
Bulbo-Spinal Atrophy, X-Linked, Toxic effect	Stem Cell Exhaustion	Here, we propose the use of SBMA patients adipose-derived mesenchymal stem cells (MSCs) as a new human in vitro model to study ARpolyQ toxicity.	25392924
Malignant Peripheral Nerve Sheath Tumor	Stem Cell Exhaustion	The patogenetic importance of Nrf2 depletion in the context of expansion of the hematopoietic progenitor pool in MPNs is discussed with particular focus upon the implications of concomitant downregulation of Nrf2 and CXCR4 for stem cell mobilization.	25397683
Communicable Diseases	Stem Cell Exhaustion	Single-nucleotide polymorphisms (SNPs) in immune genes have been associated with susceptibility to invasive mold infection (IMI) among hematopoietic stem cell but not solid-organ transplant (SOT) recipients.	25398456
Rhabdomyosarcoma	Stem Cell Exhaustion	Successful treatment of metastatic rhabdomyosarcoma with radiochemotherapy and allogeneic hematopoietic stem cell transplantation.	25398582
Rhabdomyosarcoma	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation for rhabdomyosarcoma should be done by experienced clinical oncologists on properly designed controlled trials.	25398582
Immunocompromised Host, Communicable Diseases	Stem Cell Exhaustion	Due to the increasing number of immunocompromised patients and widely used autologous stem cell transplantation procedures, clinicians have to face with the emergence of infectious diseases.	25398808
Communicable Diseases	Stem Cell Exhaustion	Herein, we present monitoring of HHV-6 virus re-activation and infection in patients after autologous stem cell transplantation.	25398808
Dermatologic disorders, Polyneuropathy	Stem Cell Exhaustion	After autologous stem cell transplantation, patients proceeded to KTd consolidation therapy, where the target doses of carfilzomib were 27 mg/m(2), 36 mg/m(2), 45 mg/m(2), or 56 mg/m(2), respectively, and thalidomide 50 mg. Common grade 3/4 adverse events included respiratory (15%), gastrointestinal (12%), and skin disorders (10%); polyneuropathy was infrequent (1%).	25398935
Neoplasms	Stem Cell Exhaustion	In addition to patient demographics, tumor pathology, treatment regimens, and clinical outcomes, we compared putative cancer stem cell marker CD133 expression patterns in primary and metastatic lesions as well as in recurrent EOC with and without CNS metastases.	25399490
Multiple Myeloma	Stem Cell Exhaustion	In vitro migratory aberrancies of mesenchymal stem cells derived from multiple myeloma patients only partially modulated by bortezomib.	25400750
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Recent studies indicated that bone marrow mesenchymal stem cells (BM-MSCs) derived from multiple myeloma (MM) patients were different from those of normal subjects in a variety of aspects.	25400750
Liver carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Downregulation of PRRX1 Confers Cancer Stem Cell-Like Properties and Predicts Poor Prognosis in Hepatocellular Carcinoma.	25404478
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Downregulation of paired related homeobox 1 (PRRX1) is associated with the acquisition of cancer stem cell (CSC)-like properties and poor prognosis in cancers.	25404478
Spinal Cord Injuries	Stem Cell Exhaustion	Safety and neurological assessments after autologous transplantation of bone marrow mesenchymal stem cells in subjects with chronic spinal cord injury.	25406723
Stanford Cancer Institute, Spinal Cord Injuries	Stem Cell Exhaustion	The administration of stem cells holds promise as a potential therapy for spinal cord injury (SCI).	25406723
Stanford Cancer Institute	Stem Cell Exhaustion	Here we evaluated the feasibility, safety and potential efficacy of autologous transplantation of mesenchymal stem cells in subjects with chronic complete SCI.	25406723
Spinal Cord Injuries	Stem Cell Exhaustion	Intralesional transplantation of autologous mesenchymal stem cells in subjects with chronic, complete spinal cord injury is safe, feasible, and may promote neurological improvements.	25406723
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	A computational model incorporating neural stem cell dynamics reproduces glioma incidence across the lifespan in the human population.	25409511
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Since evidence implicates the adult neural stem cell as the likely cell-of-origin of glioma, we have incorporated empirically-determined estimates of neural stem cell number, cell division rate, mutation rate and oncogenic potential into our model.	25409511
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Overall, our model supports the hypothesis that glioma is caused by randomly-occurring oncogenic mutations within the neural stem cell population.	25409511
Acute leukemia, Myelodysplastic-Myeloproliferative Diseases	Stem Cell Exhaustion	Initial fluconazole prophylaxis may not be required in adults with acute leukemia or myelodysplastic/myeloproliferative disorders after reduced intensity conditioning peripheral blood stem cell allogeneic transplantation.	25409914
Mycoses	Stem Cell Exhaustion	Recent changes in transplantation practices, including the use of peripheral blood stem cells (PBSC) and/or reduced intensity conditioning (RIC) regimen may have favorably impacted the epidemiology of invasive fungal infections (IFI) after allogeneic stem cell transplantation (allo-SCT).	25409914
Diabetes	Stem Cell Exhaustion	By observing the curative effect of autologous stem cells changes before and after the treatment, to explore the stem cell treatment of diabetes and its complications.	25410077
Complications of Diabetes Mellitus	Stem Cell Exhaustion	This research and application of autologous bone marrow stem cell transplantation for treatment of type 2 diabetes chronic complications achieves certain results, non-toxic side effects occuring.	25410077
Diabetes	Stem Cell Exhaustion	Clinical observation of 32 cases with transplantation of autologous bone marrow stem cells on diabetes and its complications.	25410077
Lymphoma	Stem Cell Exhaustion	Outcome determinants for transformed indolent lymphomas treated with or without autologous stem-cell transplantation.	25411416
nervous system disorder	Stem Cell Exhaustion	Umbilical cord-derived mesenchymal stem cell therapy for neurological disorders via inhibition of mitogen-activated protein kinase pathway-mediated apoptosis.	25412281
Specialty Type - cancer	Stem Cell Exhaustion	Cancer patients, specifically those undergoing invasive surgery, constitute a subgroup of patients who could benefit from autologous stem cell transplantation.	25412325
Specialty Type - cancer	Stem Cell Exhaustion	In addition, vesicles <100 nm identified as exosomes (EXOs) which may be at least partly responsible for the attributed therapeutic paracrine effects of the ADSCs were effectively isolated from ADSCs and showed equivalent miRNA content regardless they were derived from cancer patients or non-oncogenic participants indicating that the repair capabilities of xeno-free expanded ADSCs are not compromised by patient condition and therefore their xeno-free culture expanded ADSCs should be suitable for autologous stem cell transplantation in a clinical setting.	25412325
Specialty Type - cancer	Stem Cell Exhaustion	Therapeutic potential of human adipose-derived stem cells (ADSCs) from cancer patients: a pilot study.	25412325
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Equivalent outcome of autologous stem cell transplantation and reduced intensity conditioning stem cell transplantation in acute myeloid leukemia patients with t(8;21).	25413265
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We analyzed the outcome of stem cell transplantation (SCT) for 59 acute myeloid leukemia (AML) patients with t(8;21).	25413265
Neutropenia, Communicable Diseases	Stem Cell Exhaustion	Multivariable regression analysis indicated prolonged hospitalization, presence of central venous catheterization, neutropenia, current stem cell transplant, infection on admission, and old age were independently associated with higher NI incidence.	25415334
Myocardial Ischemia	Stem Cell Exhaustion	Meta-analysis of coronary artery bypass graft surgery combined with stem cell transplantation in the treatment of ischemic heart diseases.	25415856
Graft-vs-Host Disease	Stem Cell Exhaustion	Magnetic resonance enterography for assessment of intestinal graft-versus-host disease after allogeneic stem cell transplantation.	25417129
Graft-vs-Host Disease	Stem Cell Exhaustion	To determine the diagnostic performance of MR enterography (MRE) for detection and grading of gastrointestinal graft-versus-host disease (GI GvHD) after hematopoietic stem cell transplantation (SCT).	25417129
Graft-vs-Host Disease	Stem Cell Exhaustion	After allogeneic stem cell transplantation, MRE may (1) contribute to detection and localization of GI GvHD, and (2) add information indicating the clinical severity of disease, but findings are unspecific.	25417129
Ischemic cardiomyopathy	Stem Cell Exhaustion	The graft of stem cells to treat ischemic cardiomyopathy is popular in many clinical trials.	25418212
Injury of large intestine	Stem Cell Exhaustion	Complete knockout of Id1 or selective deletion of Id1 in intestinal epithelium or in LGR5+ stem cells sensitizes mice to chemical-induced colon injury.	25418719
Injury of large intestine	Stem Cell Exhaustion	These experiments identify ID1 as a marker for intestinal stem/progenitor cells and demonstrate a role for ID1 in maintaining the potential for repair in response to colonic injury.	25418719
Degenerative polyarthritis	Stem Cell Exhaustion	Here, we show that cartilage tissue harvested from the avascular inner human meniscus during the late stages of osteoarthritis harbors a unique progenitor cell population.	25418724
Childhood Breast Carcinoma	Stem Cell Exhaustion	IL-6 secreted from senescent mesenchymal stem cells promotes proliferation and migration of breast cancer cells.	25419563
Childhood Breast Carcinoma, Neoplasms	Stem Cell Exhaustion	In the current study, by establishing senescent human umbilical cord mesenchymal stem cells (s-UCMSCs) through the replicative senescence model and genotoxic stress induced premature senescence model, we show that s-UCMSCs significantly stimulate proliferation and migration of breast cancer cells in vitro and tumor progression in a co-transplant xenograft mouse model compared with 'young' counterparts (defined as MSCs at passage 5, in contrast to senescent MSCs at passage 45).	25419563
Graft-vs-Host Disease	Stem Cell Exhaustion	This study investigated the role of cytokines and chemokines in aGVHD incidence and severity in 109 patients who underwent reduced-intensity conditioning allogeneic stem cell transplantation (HSCT).	25420917
Hepatitis B	Stem Cell Exhaustion	Reactivation of hepatitis B virus in hematopoietic stem cell transplant recipients in Japan: efficacy of nucleos(t)ide analogues for prevention and treatment.	25421241
Hematologic Neoplasms	Stem Cell Exhaustion	We retrospectively reviewed 413 recipients with hematologic malignancies who underwent hematopoietic stem cell transplantation (HSCT) between June 1986 and March 2013.	25421241
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The current survey compared transplantation outcomes for a cohort of 394 acute myeloid leukemia (AML) patients given bone marrow or peripheral blood stem cells from human leukocyte antigen-identical siblings after FB (n = 218) or FM (n = 176).	25424330
Liver carcinoma	Stem Cell Exhaustion	Hypoxia after transarterial chemoembolization may trigger a progenitor cell phenotype in hepatocellular carcinoma.	25425262
Aggressive course	Stem Cell Exhaustion	Hypoxia may trigger the expression of proteins that are normally associated with cholangiocytic/progenitor cell differentiation, suggesting that TACE paradoxically causes an aggressive tumour phenotype.	25425262
Liver Cirrhosis, Hepatitis B	Stem Cell Exhaustion	Entecavir promotes CD34+ stem cell proliferation in the peripheral blood and liver of chronic hepatitis B and liver cirrhosis patients.	25425463
trauma qualifier	Stem Cell Exhaustion	ETV-activated stem cells in bone marrow and liver tissues may contribute to the recovery from injuries caused by HBV infection.	25425463
Hollings Cancer Center	Stem Cell Exhaustion	Meanwhile, ETV does not activate stem cells that may participate in the initiation of HCC.	25425463
Acinar Cell Carcinoma	Stem Cell Exhaustion	Our studies indicate that activation of mTOR signaling in the pancreatic progenitor cells may trigger the development of acinar carcinoma.	25425965
Specialty Type - cancer, Neoplasms, Glioblastoma	Stem Cell Exhaustion	The AC133 epitope of CD133 is a cancer stem cell (CSC) marker for many tumor entities, including the highly malignant glioblastoma multiforme (GBM).	25426558
Adult Glioblastoma	Stem Cell Exhaustion	Patient-derived glioblastoma stem cells are killed by CD133-specific CAR T cells but induce the T cell aging marker CD57.	25426558
Neoplasms	Stem Cell Exhaustion	We have developed an AC133-specific chimeric antigen receptor (CAR) and show that AC133-CAR T cells kill AC133+ GBM stem cells (GBM-SCs) both in vitro and in an orthotopic tumor model in vivo.	25426558
Chronic total occlusion of coronary artery	Stem Cell Exhaustion	Safety and efficacy of intracoronary human umbilical cord-derived mesenchymal stem cell treatment for very old patients with coronary chronic total occlusion.	25427243
Chronic total occlusion of coronary artery	Stem Cell Exhaustion	This study aimed to investigate the safety and feasibility of intracoronary injection of human umbilical cord mesenchymal stem cell to the very old patients with coronary chronic total occlusion.	25427243
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We report results of a time-dependent multivariable analysis of allogenic hematopoietic stem cell transplantation (alloHSCT) (n=337) versus chemotherapy (n=271) or autologous HSCT (autoHSCT) (n=152) in 760 patients aged 40-60 years with AML in CR1.	25428261
Specialty Type - cancer, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Cancer stem cell is responsible for tumor initiation, metastasis and relapse.	25428381
Neoplasms, Invasive Ductal Breast Carcinoma	Stem Cell Exhaustion	Correlation between epidermal growth factor receptor and tumor stem cell markers CD44/CD24 and their relationship with prognosis in breast invasive ductal carcinoma.	25429827
Neoplasms, Invasive Ductal Breast Carcinoma	Stem Cell Exhaustion	We studied the correlation between epidermal growth factor receptor (EGFR) and the tumor stem cell markers CD44/CD24 in breast invasive ductal carcinoma (BIDC) and their relationship with prognosis.	25429827
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are clonal disorders of hematopoietic stem/progenitor cells.	25430081
Amyloidosis	Stem Cell Exhaustion	Only high-dose melphalan with auto-peripheral blood stem cell transplantation (PBSCT) has shown high long-term hematological response rates, but combinations with novel agents, including bortezomib or lenalidomide, have recently shown high hematological response rates for AL amyloidosis patients.	25430082
Acute leukemia, Infertility	Stem Cell Exhaustion	As the number of young long-term survivors of hematopoietic stem cell transplantation (HSCT) for acute leukemia continues to increase, post-transplant infertility is becoming a significant concern.	25430084
leukemia	Stem Cell Exhaustion	Total costs and clinical outcome of hematopoietic stem cell transplantation in adults with leukemia: comparison between reduced-intensity and myeloablative conditioning.	25430486
Primary Biliary Cholangitis	Stem Cell Exhaustion	CoH loss, reflecting a reduced supply of progenitor cells to the biliary tree, may be involved in the histological progression of PBC.	25430494
Gastrointestinal mucositis	Stem Cell Exhaustion	The relationship between oral mucositis and levels of pro-inflammatory cytokines in serum and in gingival crevicular fluid in allogeneic stem cell recipients.	25433441
Gastrointestinal mucositis, Oman	Stem Cell Exhaustion	Oral mucositis (OM) is a severe side effect of conditioning for allogeneic hematopoietic stem cell transplantation (HSCT).	25433441
Acute leukemia	Stem Cell Exhaustion	A survey on unmanipulated haploidentical hematopoietic stem cell transplantation in adults with acute leukemia.	25434302
Acute leukemia	Stem Cell Exhaustion	The use of unmanipulated graft is increasingly adopted in the setting of allogeneic hematopoietic stem cell transplantation from haploidentical family donors (haplo-SCT) in acute leukemia (AL).	25434302
Anemia	Stem Cell Exhaustion	Oxymetholone therapy of fanconi anemia suppresses osteopontin transcription and induces hematopoietic stem cell cycling.	25434823
Bone marrow hypocellularity	Stem Cell Exhaustion	These results expand our knowledge of the regulation of hematopoietic stem cell proliferation and have direct clinical implications for the treatment of bone marrow failure.	25434823
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation in multiple myeloma is not dead but alive and well.	25435056
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	In multiple myeloma (MM), the use of high-dose chemotherapy with autologous stem cell transplantation (ASCT) led to incremental advances in patient management in the 1990s.	25435056
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	CD133 is one of the cancer stem cell markers in solid cancers.	25436343
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells (CSC) was reported to play an important role in various kinds of cancer.	25436343
Peripheral Blood Stem Cells	Stem Cell Exhaustion	All patients received peripheral blood stem cell infusion >1.5 x 10(6)/kg.	25437249
Neuroendocrine Tumors, Neoplasms	Stem Cell Exhaustion	Neuroendocrine tumors (NETs) of the ileum are sporadic tumors derived from submucosal gastrointestinal stem cells.	25439321
Malignant neoplasm of stomach, Specialty Type - cancer	Stem Cell Exhaustion	Combined epithelial-mesenchymal transition with cancer stem cell-like marker as predictors of recurrence after radical resection for gastric cancer.	25441488
Malignant neoplasm of stomach	Stem Cell Exhaustion	The aim of the study was to identify the incidence and the predictors of recurrence after curative resection and the clinical significance of epithelial-mesenchymal transition (EMT) and stem cell-like phenotypes in gastric cancer.	25441488
Malignant neoplasm of stomach	Stem Cell Exhaustion	The clinicopathological characteristics, including five EMT-related proteins (Snail-1, ZEB-1, E-cadherin, vimentin, and b-catenin) and the gastric cancer stem cell markers CD44 and CD54, therapeutic modalities, survival time after recurrence, and recurrence patterns were compared between the two groups.	25441488
Malignant neoplasm of stomach	Stem Cell Exhaustion	Loss of E-cadherin expression and aberrant expression of vimentin and the known gastric cancer stem cell maker CD44 were significantly associated with aggressive clinicopathologic features.	25441488
Neoplasms, Malignant neoplasm of stomach, Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	Multivariate analysis showed that stage III gastric cancer patients with early recurrence had larger tumors and more lymph node metastasis, coupled with aberrant expression EMT and cancer stem cell marker, than patients with late recurrence.	25441488
Malignant neoplasm of stomach, Specialty Type - cancer	Stem Cell Exhaustion	Combined EMT with cancer stem cell-like marker is a predictor of recurrence after radical resection for gastric cancer.	25441488
Ischemic stroke	Stem Cell Exhaustion	Circulating CD133+ CD34+ progenitor cells and plasma stromal-derived factor-1alpha: predictive role in ischemic stroke patients.	25444027
Chemical injury	Stem Cell Exhaustion	Circulating progenitor cells and stromal-derived factor-1alpha (SDF-1a) have been suggested to participate in tissue repair after ischemic injury.	25444027
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Patients with multiple myeloma (MM) who are eligible for autologous stem cell transplantation (ASCT) typically receive a finite period of initial therapy before ASCT.	25445028
Multiple Myeloma	Stem Cell Exhaustion	Quantitative measures of physical functioning after autologous hematopoietic stem cell transplantation in multiple myeloma: a feasibility study.	25445473
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The safety and feasibility of the symptom-limited cardiopulmonary exercise test (CPET) and the 6-minute walk test (6MWT) has not been rigorously tested in patients with multiple myeloma (MM) after high-dose chemotherapy with autologous stem cell transplantation (ASCT), nor have correlations with patient-reported outcomes (PROs) been explored.	25445473
Hematologic Neoplasms	Stem Cell Exhaustion	Nonmyeloablative allogeneic hematopoietic stem cell transplant for the treatment of patients with hematologic malignancies using busulfan, fludarabine, and total body irradiation conditioning is effective in an elderly and infirm population.	25445641
Hematologic Neoplasms	Stem Cell Exhaustion	Patients with hematologic malignancies for whom limited long-term survival was expected with standard therapy were administered an outpatient conditioning regimen of busulfan 3.2 mg/kg IV on day -5, fludarabine 30 mg/m(2) IV on days -4, -3, -2, and 200 cGy of total body irradiation (TBI) followed by stem cell infusion from related or unrelated donors.	25445641
diabetic	Stem Cell Exhaustion	Normalization of wound healing and stem cell marker patterns in organ-cultured human diabetic corneas by gene therapy of limbal cells.	25446319
diabetic	Stem Cell Exhaustion	Overexpression of c-met and suppression of matrix metalloproteinase-10 (MMP-10) and cathepsin F genes was previously shown to normalize wound healing, epithelial and stem cell marker patterns in organ-cultured human diabetic corneas.	25446319
diabetic	Stem Cell Exhaustion	Corneal cryostat sections were immunostained for diabetic and putative limbal stem cell markers, a3b1 integrin, nidogen-1, fibronectin, laminin g3 chain, DNp63a, keratins 14, 15, and 17, as well as for activated signaling intermediates, phosphorylated EGFR, Akt, and p38.	25446319
Keratopathy, diabetic	Stem Cell Exhaustion	Gene therapy of limbal epithelial stem cell compartment has a beneficial effect on the diabetic corneal wound healing and on diabetic and stem cell marker expression, and shows potential for alleviating symptoms of diabetic keratopathy.	25446319
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Current valid treatments for acute myeloid leukemia (AML) include chemotherapy and hematopoietic stem cell transplantation, which are defective and limited respectively.	25448401
MS gene, Spinal Cord Injuries, Parkinson Disease, Cerebrovascular accident	Stem Cell Exhaustion	The top five clinical indications for stem cell therapy were multiple sclerosis, anti-ageing, Parkinson's disease, stroke and spinal cord injury.	25449045
Pathogenesis of HIV Opportunistic Infection	Stem Cell Exhaustion	Human adenoviruses (HAdV) are known opportunistic pathogens in hematopoietic stem cell transplant (SCT) recipients.	25449172
Prostate carcinoma	Stem Cell Exhaustion	Loss of E-cadherin expression, a marker of EMT, and CD133, a putative prostate cancer stem cell marker, were characterized using the open channel of the CellSearch platform.	25450039
Graft-vs-Host Disease	Stem Cell Exhaustion	Achievement of early complete donor chimerism in CD25+-activated leukocytes is a strong predictor of the development of graft-versus-host-disease after stem cell transplantation.	25450515
Communicable Diseases	Stem Cell Exhaustion	Disseminated, persistent, and fatal infection due to the vaccine strain of varicella-zoster virus in an adult following stem cell transplantation.	25452596
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	A middle-aged man with non-Hodgkin lymphoma received chemotherapy and a stem cell transplant.	25452596
Chronic myeloproliferative disorder, PRSS27 gene, Neoplasms, Precursor B-cell lymphoblastic leukemia	Stem Cell Exhaustion	B-lymphoblastic leukemia (B-ALL) is a neoplasm of precursors committed to B-cell lineage, whereas myeloproliferative neoplasm (MPN) is a clonal proliferation derived from myeloid stem cells.	25453399
Graft-vs-Host Disease	Stem Cell Exhaustion	Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial.	25456364
Graft-vs-Host Disease	Stem Cell Exhaustion	Interleukin 6 mediates graft-versus-host disease (GVHD) in experimental allogeneic stem-cell transplantation (allogeneic SCT) and represents an attractive therapeutic target.	25456364
Sezary Syndrome	Stem Cell Exhaustion	Long-Term Complete Responses to Combination Therapies and Allogeneic Stem Cell Transplants in Patients With Sezary Syndrome.	25458083
Mouth Diseases	Stem Cell Exhaustion	To report an oral disease management protocol before and after hematopoietic stem cell transplantation.	25458262
Ischemia, Acute lymphocytic leukemia	Stem Cell Exhaustion	Nonocclusive Mesenteric Ischemia after Chemotherapy in an Adolescent Patient with a History of Three Allogeneic Hematopoietic Stem Cell Transplantations for Acute Lymphoblastic Leukemia.	25458640
Age related macular degeneration, "Stargardts disease", Dystrophy	Stem Cell Exhaustion	Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies.	25458728
Neoplasms	Stem Cell Exhaustion	Since they were first derived more than three decades ago, embryonic stem cells have been proposed as a source of replacement cells in regenerative medicine, but their plasticity and unlimited capacity for self-renewal raises concerns about their safety, including tumour formation ability, potential immune rejection, and the risk of differentiating into unwanted cell types.	25458728
Cessation of life	Stem Cell Exhaustion	If targeted to a gene promoting cellular survival or decreasing cell death, it could potentially improve stem cell longevity in a more efficient and controllable manner.	25459138
Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	Each mutation is rare and the specific set is extremely rare so that even though there are millions of stem cells in a small area of mucosa the specific set of mutations to initiate the process of malignancy will only arise in one stem cell at most; hence neoplasia is clonal.	25459141
Inflammation, Trauma, Specialty Type - cancer, Ulceration, CTCAE	Stem Cell Exhaustion	This hierarchical model of stem cell genesis leads to a very low prevalence of cancer, unless the orderly progression of the hierarchy is disturbed by inflammation, ulceration or trauma.	25459141
Carcinogenesis	Stem Cell Exhaustion	The central dogma of carcinogenesis is that deleterious mutations accumulate in regularly cycling stem cells and eventually one of the cells will acquire a specific set of mutations which leads to uncontrolled cell proliferation.	25459141
Carcinogenesis	Stem Cell Exhaustion	It is suggested that the number of cell divisions that separate the zygote from stem cells is a key variable in carcinogenesis.	25459141
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Feasible outcomes of T cell-replete haploidentical stem cell transplantation with reduced-intensity conditioning in patients with myelodysplastic syndrome.	25459640
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Even with the recent optimization of haploidentical stem cell transplantation (SCT), its role for patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia evolving from MDS (sAML) should be validated.	25459640
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic graft-versus-host disease (cGVHD) is a serious and frequent complication of allogeneic hematopoietic stem cell transplantation (HCT).	25460358
Nephroblastoma, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Wilms tumor gene 1 expression as a predictive marker for relapse and survival after hematopoietic stem cell transplantation for myelodysplastic syndromes.	25460359
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Nephroblastoma	Stem Cell Exhaustion	Relapse after allogeneic hematopoietic stem cell transplantation (HSCT) is a major concern in myelodysplastic syndromes (MDS), but the role of Wilms tumor gene 1 (WT1) as a predictive marker for post-HSCT relapse remains to be validated.	25460359
Hyperglycemia, Acute Coronary Syndrome	Stem Cell Exhaustion	Correction of hyperglycemia in patients with acute coronary syndrome rapidly reverses oxidative stress, restoring both platelet nitric oxide responsiveness and endothelial progenitor cell function, but this process is largely or entirely independent of thioredoxin-interacting protein.	25460870
Primary Myelofibrosis	Stem Cell Exhaustion	Myelofibrosis (MF) is characterized by the constitutive mobilization of hematopoietic stem cells (HSC) and hematopoietic progenitor cells (HPC) and the establishment of extramedullary hematopoiesis.	25461253
Stanford Cancer Institute	Stem Cell Exhaustion	At 0 to 3 DPI, levels of cytokines interleukin-6 (P<.00017), interleukin-9 (P<.0047), interleukin-16 (P<.007), interleukin-18 (P<.014), chemokines growth-related oncogene a/chemokine (C-X-C motif) ligand 1 (P<.0127) and macrophage inflammatory protein 1-b/chemokine (C-C motif) ligand 4 (P<.0015), and growth factors hepatocyte growth factor (HGF) (P<.0001) and stem cell growth factor-b (P<.0103) were also significantly elevated in subjects with acute SCI.	25461821
Systolic dysfunction	Stem Cell Exhaustion	Hematopoietic stem cell transplantation in patients with systolic dysfunction: can it be done?	25464117
leukemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We analyzed adult patients with leukemia or myelodysplastic syndrome who received a first allogeneic stem cell transplant from an HLA-A, -B, -C, and -DRB1 matched or 1-allele mismatched unrelated donor in Japan.	25464119
Acute myocardial infarction	Stem Cell Exhaustion	Concurrent hypermulticolor monitoring of CD31, CD34, CD45 and CD146 endothelial progenitor cell markers for acute myocardial infarction.	25467496
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	The circulating endothelial progenitor cells (EPCs) in blood of acute myocardial infarction (AMI) patient have been monitored in many previous studies.	25467496
Childhood Breast Carcinoma	Stem Cell Exhaustion	Mithramycin A sensitizes therapy-resistant breast cancer stem cells toward genotoxic drug doxorubicin.	25468484
Specialty Type - cancer	Stem Cell Exhaustion	Accumulating evidence suggests a major role of cancer stem cells (CSCs) in chemoresistance evoking the requirement of drugs that selectively target CSCs in combination with chemotherapy.	25468484
Mandibular Fractures	Stem Cell Exhaustion	The osteogenic activity of human mandibular fracture haematoma-derived progenitor cells is affected by bisphosphonate in vitro.	25468633
atherosclerotic	Stem Cell Exhaustion	Lower levels of plasma adiponectin and endothelial progenitor cells are associated with large artery atherosclerotic stroke.	25469454
Toxic effect, Primary Myelofibrosis	Stem Cell Exhaustion	Treosulfan based reduced toxicity conditioning followed by allogeneic stem cell transplantation in patients with myelofibrosis.	25469485
Liver diseases	Stem Cell Exhaustion	Efforts to identify cell sources and approaches for cell therapy of liver diseases are ongoing, taking into consideration the limits recognized for adult liver tissue and for other forms of stem cells.	25471120
Liver Cirrhosis	Stem Cell Exhaustion	In the present study, we described the first procedure of via hepatic artery transplantation of human fetal biliary tree stem cells in patients with advanced cirrhosis.	25471120
Liver Cirrhosis	Stem Cell Exhaustion	This report represents proof of the concept that the human fetal biliary tree stem cells are a suitable and large source for cell therapy of liver cirrhosis.	25471120
Liver Cirrhosis	Stem Cell Exhaustion	Transplantation of human fetal biliary tree stem/progenitor cells into two patients with advanced liver cirrhosis.	25471120
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Stem Cell Exhaustion	A 17-month-old male patient diagnosed with T-cell acute lymphoblastic leukemia underwent allogeneic stem cell transplantation.	25472557
Psoriasis	Stem Cell Exhaustion	Generalized pustular psoriasis following allogeneic stem cell transplantation.	25472781
Psoriasis	Stem Cell Exhaustion	Development of psoriasis following allogeneic stem cell transplantation (SCT) is rare, and has been described once previously, following SCT from a sibling donor with psoriasis.	25472781
Neurofibromatoses	Stem Cell Exhaustion	Proposing the use of dental pulp stem cells as a suitable biological model of neurofibromatosis type 1.	25480698
Neurofibromatoses	Stem Cell Exhaustion	This study aims to propose the dental pulp stem cells (DPSCs) as a model for studying two features related to neurofibromatosis type 1 (NF1), i.e.	25480698
Coronary Arteriosclerosis	Stem Cell Exhaustion	Determinants of neointimal proliferation and stent coverage after intracoronary therapy with drug-eluting devices in stable coronary artery disease: role of endothelial progenitor cells and interleukin-1 family cytokines.	25480994
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A cytogenetic model predicts relapse risk and survival in patients with acute myeloid leukemia undergoing hematopoietic stem cell transplantation in morphologic complete remission.	25481050
Alopecia, Cataract	Stem Cell Exhaustion	Broad induction at weaning inhibited proliferation of intestinal transit-amplifying and Lgr5+ stem cells and rapidly imposed features of aging, including hair loss, skin wrinkling, reduced body weight and subcutaneous fat, an increased myeloid fraction in peripheral blood, poor dentition, and cataracts.	25481981
Graft-vs-Host Disease, Stomatitis	Stem Cell Exhaustion	Mammalian target of rapamycin inhibitor-associated stomatitis in hematopoietic stem cell transplantation patients receiving sirolimus prophylaxis for graft-versus-host disease.	25482865
Graft-vs-Host Disease	Stem Cell Exhaustion	The mammalian target of rapamycin (mTOR) inhibitor sirolimus is effective in reducing incidence of graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT).	25482865
diabetic	Stem Cell Exhaustion	Short-term statin discontinuation increases endothelial progenitor cells without inflammatory rebound in type 2 diabetic patients.	25483979
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Type 2 diabetes (T2D) is characterized by impaired vascular regeneration owing to reduced endothelial progenitor cells (EPCs).	25483979
Kidney Diseases	Stem Cell Exhaustion	BK virus nephropathy in a pediatric patient after hematopoietic stem cell transplantation.	25484248
Nephroblastoma, Acute lymphocytic leukemia	Stem Cell Exhaustion	A 15-year-old girl with acute lymphoblastic leukemia received allogeneic dendritic cell vaccination, pulsed with Wilms tumor 1 (WT1) peptide, after her third hematopoietic stem cell transplantation (HSCT).	25484308
Splenomegaly	Stem Cell Exhaustion	These patients may develop splenomegaly and require splenectomy to alleviate mechanical symptoms, to ameliorate transfusion-dependent cytopenias, or to enhance stem cell transplantation.	25488568
Fibrosis Assessment	Stem Cell Exhaustion	In a mouse model of liver fibrosis, systemic injection of bone marrow mesenchymal stem cells (BM-MSCs) was considered to rescue the diseased phenotype.	25490388
Fibrosis Assessment	Stem Cell Exhaustion	Therapeutic potential of human adipose tissue-derived multi-lineage progenitor cells in liver fibrosis.	25490388
Fibrosis Assessment	Stem Cell Exhaustion	The aim of this study was to assess the effectiveness of human adipose tissue-derived multi-lineage progenitor cells (hADMPCs) in improving liver fibrosis.	25490388
Hodgkin Disease	Stem Cell Exhaustion	[Treatment and prognosis of relapsed or refractory Hodgkin lymphoma patients ineligible for stem cell transplantation].	25493581
LIPC gene	Stem Cell Exhaustion	Currently, there is no widely accepted standard treatment strategy in relapsed/refractory HL patients ineligible for autologous stem cell transplantation (ASCT).	25493581
Refractory Disease, Cardiotoxicity	Stem Cell Exhaustion	High-dose chemotherapy and ASCT was not indicated due to advanced age (seven patients), chemorefractory disease (seven patients), cardiotoxicity (two patients) and insufficient stem cell collection of CD34+ cells (one patient).	25493581
Granulocyte-Macrophage Progenitor Cells, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	This phase I/II study assessed the safety, immunity and clinical response to 6 or 12 bi-weekly intradermal ImMucin vaccines, co-administered with human granulocyte-macrophage colony-stimulating factor to 15 MUC1-positive multiple myeloma (MM) patients, with residual or biochemically progressive disease following autologous stem cell transplantation.	25496030
Bacterial Infections	Stem Cell Exhaustion	Increased bacterial infections after transfusion of leukoreduced non-irradiated blood products in recipients of allogeneic stem cell transplants after reduced-intensity conditioning.	25498924
Graft-vs-Host Disease	Stem Cell Exhaustion	Blood components transfused to hematopoietic stem cell transplant (HSCT) recipients are irradiated to prevent transfusion-associated graft-versus-host disease (TA-GVHD).	25498924
Dyskeratosis Congenita	Stem Cell Exhaustion	Bone marrow skeletal stem/progenitor cell defects in dyskeratosis congenita and telomere biology disorders.	25499762
Colorectal Carcinoma	Stem Cell Exhaustion	Meanwhile, SIRT1 expression had a co-localization with CD133, a current universal marker to characterize colorectal cancer stem cells (CSCs).	25500546
B-Cell Lymphomas	Stem Cell Exhaustion	Fatal visceral varicella-zoster developing early after autologous hematopoietic stem cell transplantation for refractory diffuse large B-cell lymphoma.	25501115
Lymphoma	Stem Cell Exhaustion	A middle-aged woman who had undergone autologous hematopoietic stem cell transplantation (HSCT) 1 month previously suffered severe epigastralgia and relapse of lymphoma.	25501115
Specialty Type - cancer	Stem Cell Exhaustion	Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility, and tropism to brain cancer.	25501828
Sarcopenia	Stem Cell Exhaustion	Although the etiology of sarcopenia is unknown, the correlation during aging between the loss of activity of satellite cells, which are endogenous muscle stem cells, and impaired muscle regenerative capacity has led to the hypothesis that the loss of satellite cell activity is also a cause of sarcopenia.	25501907
Lymphoma, Follicular	Stem Cell Exhaustion	Autologous stem cell transplantation with in vivo purged progenitor cells shows long-term efficacy in relapsed/refractory follicular lymphoma.	25502635
Lymphoma, Follicular	Stem Cell Exhaustion	High-dose chemotherapy with autologous stem cell transplantation (ASCT) has been shown effective in the control of relapsed/refractory follicular lymphoma.	25502635
Malignant neoplasm of stomach	Stem Cell Exhaustion	Genome-wide association studies revealed a link between gastric cancer (GC) and single nucleotide polymorphisms (SNPs) of prostate stem cell antigen (PSCA), phospholipase C epsilon-1 (PLCE1) and mucin-1 (MUC1) genes.	25503145
Gastrointestinal mucositis	Stem Cell Exhaustion	Polaprezinc prevents oral mucositis in patients treated with high-dose chemotherapy followed by hematopoietic stem cell transplantation.	25503160
Hematologic Neoplasms, Gastrointestinal mucositis	Stem Cell Exhaustion	The present study was designed to investigate whether P-AG prevents oral mucositis in all patients (36 patients) with hematological malignancy receiving high-dose chemotherapy and radiotherapy followed by hematopoietic stem cell transplantation (HSCT).	25503160
Secondary malignant neoplasm of liver	Stem Cell Exhaustion	Portal vein embolisation with application of haematopoietic stem cells in patients with primarily or non-resectable colorectal liver metastases.	25503161
Dyspnea, CTCAE, Fever	Stem Cell Exhaustion	Dyspnea and fever in an allogeneic stem cell recipient.	25504499
Hypoxia	Stem Cell Exhaustion	Data showed that chemical-induced hypoxia changed cell stemness by enhancing stem cell transcription factors and markers of chemotherapeutic drug resistance.	25512094
Specialty Type - cancer	Stem Cell Exhaustion	The CD166-positive cancer stem cell-like population showed greater drug resistance than the CD166-negative cells.	25512094
Behavior, Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	Since cancer stem cells exhibit embryonic-like self-renewal characteristics and malignant behavior, including drug resistance and metastasis, they may be the origin of tumorigenesis and cancer recurrence.	25512094
Specialty Type - cancer, Hypoxia	Stem Cell Exhaustion	Our findings indicate that chemical hypoxia may augment cancer cell stemness and drug resistance in CD166-positive stem cells.	25512094
Anemia, PAFAH1B1 wt Allele, Dysplasia, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	tet2(m/m) (homozygous for the mutation) zebrafish exhibited normal embryonic and larval hematopoiesis but developed progressive clonal myelodysplasia as they aged, culminating in myelodysplastic syndromes (MDS) at 24 months of age, with dysplasia of myeloid progenitor cells and anemia with abnormal circulating erythrocytes.	25512612
PAFAH1B1 wt Allele, Malignant Neoplasms, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Somatic loss-of-function mutations of TET2 are frequently observed in human myelodysplastic syndrome (MDS), which is a clonal malignancy characterized by dysplastic changes of developing blood cell progenitors, leading to ineffective hematopoiesis.	25512612
Autoimmune Diseases, Autoimmune state	Stem Cell Exhaustion	While autoimmune disease can occur after solid organ and stem cell transplant, our patient developed skin manifestations of autoimmunity after liver transplantation, which is also rarely described.	25516432
Tuberculosis	Stem Cell Exhaustion	Long-term risk of tuberculosis in haematopoietic stem cell transplant recipients: a 10-year nationwide study.	25519791
Tuberculosis	Stem Cell Exhaustion	Tuberculosis (TB) is a serious problem for patients undergoing haematopoietic stem cell transplantation (HSCT) in TB-endemic areas; however, data on these patients are limited.	25519791
Aplastic Anemia, Peritonitis	Stem Cell Exhaustion	We report the case of an 11-year-old girl with aplastic anemia on ambulatory peritoneal dialysis who had Mycobacterium avium complex-associated peritonitis after allogeneic hematopoietic stem cell transplantation (allo-HSCT).	25521993
leukemia	Stem Cell Exhaustion	In a multicentre, single-arm, open-label phase 2 study, we enrolled adult patients with Philadelphia-chromosome-negative, primary refractory or relapsed (first relapse within 12 months of first remission, relapse within 12 months after allogeneic haemopoietic stem-cell transplantation [HSCT], or no response to or relapse after first salvage therapy or beyond) leukaemia.	25524800
Neoplasms	Stem Cell Exhaustion	Isolated cells, both from GH(+) and NS tumors, satisfy all the criteria for the identification of PMCs and express known stem cell markers (OCT4, SOX2, KLF4, NANOG), but do not express markers of pituitary hormone cell types (PITX2, PROP1, PIT1).	25525036
Pituitary Neoplasms, Neoplasms	Stem Cell Exhaustion	We demonstrated that pituitary tumors contain a stem cell population that can generate cell types characteristic of mesenchymal stem cells, and express CD133, which is associated with CSCs in other tumors.	25525036
Specialty Type - cancer	Stem Cell Exhaustion	The Cancer Stem Cells (CSCs) theory suggests that genetic alterations in stem cells are the direct cause for cancer.	25525036
Heart failure	Stem Cell Exhaustion	Atorvastatin treatment improves endothelial function through endothelial progenitor cells mobilization in ischemic heart failure patients.	25525743
Drug-Induced Ototoxicity	Stem Cell Exhaustion	Emerging hepatic models for the study of drug-induced toxicity include pluripotent stem cell-derived hepatocyte-like cells (HLCs) and complex hepatocyte-non-parenchymal cellular coculture to mimic the complex multicellular interactions that recapitulate the niche environment in the human liver.	25527335
Toxic effect, Drug-Induced Ototoxicity	Stem Cell Exhaustion	In this study, we demonstrate that microRNA-122 (miR-122) detection in cell culture media can be used as a hepatocyte-enriched in vitro marker of drug-induced toxicity in homogeneous cultures of hepatic cells, and a cell-specific marker of toxicity of hepatic cells in heterogeneous cultures such as HLCs generated from various differentiation protocols and pluripotent stem cell lines, where conventional cytotoxicity assays using generic cellular markers may not be appropriate.	25527335
Acute lymphocytic leukemia	Stem Cell Exhaustion	Tyrosine kinase inhibitors improve long-term outcome of allogeneic hematopoietic stem cell transplantation for adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia.	25527562
B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1	Stem Cell Exhaustion	This study aimed to determine the impact of tyrosine kinase inhibitors given pre- and post-allogeneic stem cell transplantation on long-term outcome of patients allografted for Philadelphia chromosome-positive acute lymphoblastic leukemia.	25527562
leukemia, B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1	Stem Cell Exhaustion	This retrospective analysis from the EBMT Acute Leukemia Working Party included 473 de novo Philadelphia chromosome-positive acute lymphoblastic leukemia patients in first complete remission who underwent an allogeneic stem cell transplantation using a human leukocyte antigen-identical sibling or human leukocyte antigen-matched unrelated donor between 2000 and 2010.	25527562
Acute lymphocytic leukemia	Stem Cell Exhaustion	Over the past decade, administration of tyrosine kinase inhibitors before allogeneic stem cell transplantation has significantly improved the long-term allogeneic stem cell transplantation outcome of adult Philadelphia chromosome-positive acute lymphoblastic leukemia.	25527562
Varicella Zoster Encephalitis	Stem Cell Exhaustion	Varicella zoster virus encephalomyelitis as a late complication following haematopoietic stem cell transplantation.	25527690
Multiple Myeloma	Stem Cell Exhaustion	The patient had a history of multiple myeloma diagnosed 2 years earlier, treated with chemotherapy and autologous stem cell transplant.	25527690
herpesvirus 3, human	Stem Cell Exhaustion	VZV should be considered in patients with haematopoietic stem cell transplantation presenting with similar neurological manifestations even in the absence of dermatological signs.	25527690
Acute GVH disease	Stem Cell Exhaustion	High number of memory t cells is associated with higher risk of acute graft-versus-host disease after allogeneic stem cell transplantation.	25528387
Chronic graft-versus-host disease	Stem Cell Exhaustion	We previously reported a risk score that predicted mortality in patients with chronic graft-versus-host disease (CGVHD) after hematopoietic stem cell transplantation (HCT) between 1995 and 2004 and reported to the Center for International Blood and Marrow Transplant Research (CIBMTR).	25528390
Respiratory Distress Syndrome, Adult	Stem Cell Exhaustion	The STem cells for ARDS Treatment (START) trial was a multicentre, open-label, dose-escalation, phase 1 clinical trial.	25529339
Multiple Myeloma	Stem Cell Exhaustion	Second autologous stem cell transplant: an effective therapy for relapsed multiple myeloma.	25529381
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Therapeutic options for patients with multiple myeloma (MM) whose disease has relapsed after a prior autologous stem cell transplant (ASCT) include an expanding armamentarium of novel agents, often combined with traditional chemotherapy, or a second ASCT, with no clear standard of care.	25529381
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Comparison of unrelated cord blood and peripheral blood stem cell transplantation in adults with myelodysplastic syndrome after reduced-intensity conditioning regimen: a collaborative study from Eurocord (Cord blood Committee of Cellular Therapy & Immunobiology Working Party of EBMT) and Chronic Malignancies Working Party.	25529382
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) remains the only curative treatment in patients with higher risk myelodysplastic syndrome (MDS), but the choice of the optimal alternative stem cell source is still a subject of debate in patients lacking an HLA-matched sibling donor.	25529382
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Here, we report on a large series of patients with MDS (N = 631) transplanted either with mobilized peripheral stem cells (PBs) from unrelated donors (n = 502) or with umbilical cord blood transplant (UCB, n = 129) as alternative grafts after reduced-intensity conditioning.	25529382
PAFAH1B1 wt Allele	Stem Cell Exhaustion	We conclude that in MDS patients lacking an HLA-matched sibling donor, PB from a 10/10 HLA-matched unrelated donor is the preferred source of hematopoietic stem cells.	25529382
Multiple Myeloma	Stem Cell Exhaustion	Changing trends in prognostic factors for patients with multiple myeloma after autologous stem cell transplantation during the immunomodulator drug/proteasome inhibitor era.	25530023
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We evaluated the clinical significance of prognostic factors including the International Staging System (ISS) and modified European Group for Blood and Marrow Transplantation response criteria in 1650 Japanese patients with multiple myeloma (MM) who underwent upfront single autologous stem cell transplantation (ASCT).	25530023
Up	Stem Cell Exhaustion	Specifically, neural stem cell transplantation as a treatment for AD offers a novel approach with tremendous therapeutic potential.	25530343
Neurodegenerative Disorders	Stem Cell Exhaustion	These promising findings prompted us to examine a human neural stem cell population, HuCNS-SC, which has already been clinically tested for other neurodegenerative disorders.	25530343
Alzheimers Disease", Neuronal loss in central nervous system	Stem Cell Exhaustion	Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss.	25530343
Impaired cognition	Stem Cell Exhaustion	Over the last decade, the potential use of stem cells to treat cognitive impairment has received growing attention.	25530343
Neuronal loss in central nervous system	Stem Cell Exhaustion	We previously reported that intrahippocampal transplantation of murine neural stem cells (mNSCs) can enhance synaptogenesis and improve cognition in 3xTg-AD mice and the CaM/Tet-DT(A) model of hippocampal neuronal loss.	25530343
Intrinsic Factor Deficiency	Stem Cell Exhaustion	Recurrence of IFD after chemotherapy or hematopoietic stem cell transplantation (HSCT) is associated with poor prognosis.	25531544
Hodgkin Disease	Stem Cell Exhaustion	We present response and survival outcomes of a pivotal phase 2 trial of the antibody-drug conjugate brentuximab vedotin in patients with relapsed/refractory Hodgkin lymphoma following autologous stem cell transplant (N = 102) after a median observation period of approximately 3 years.	25533035
Lupus Vulgaris	Stem Cell Exhaustion	Differential expression of the transcription factor ARID3a in lupus patient hematopoietic progenitor cells.	25535283
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	CD90 (Thy-1) plays important roles in oncogenesis and shows potential as a candidate marker for cancer stem cells (CSCs) in various malignancies.	25536077
Hepatitis	Stem Cell Exhaustion	Transient grades 3 to 4 acute hepatitis is a common complication of rabbit antithymocyte globulin (thymoglobulin) administered before allogeneic stem cell transplantation.	25536216
Childhood Breast Carcinoma	Stem Cell Exhaustion	By promoting cell differentiation, miR-100 sensitizes basal-like breast cancer stem cells to hormonal therapy.	25537513
Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	Tumor formation and relapse are sustained by a cell subset of Breast Cancer Stem Cells (BrCSCs).	25537513
S100A4 protein, human	Stem Cell Exhaustion	The authors characterized human adipose-derived stem cells at different in vitro culture time points in terms of immunophenotype, multilineage differentiation, long-term survival with self-renewal capacity, and presence of telomere maintenance mechanisms (telomerase activity and alternative lengthening of telomere) for excluding their eventual susceptibility to malignant transformation.	25539318
S100A4 protein, human	Stem Cell Exhaustion	The results support the concept that in vitro expanded adipose-derived stem cells obtained from fat tissue are not susceptible to developing one of the hallmarks of malignant transformation and can be considered amenable for cell therapy approaches.	25539318
Cessation of life, HD Term Type	Stem Cell Exhaustion	Small-molecule ATM inhibitors reduced mHTT-induced death of rat striatal neurons and induced pluripotent stem cells derived from HD patients.	25540325
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Treatment of acute myeloid leukemia or myelodysplastic syndrome relapse after allogeneic stem cell transplantation with azacitidine and donor lymphocyte infusions--a retrospective multicenter analysis from the German Cooperative Transplant Study Group.	25540937
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute, MYELOPROLIFERATIVE SYNDROME, TRANSIENT	Stem Cell Exhaustion	To expand the current knowledge about azacitidine (Aza) and donor lymphocyte infusions (DLI) as salvage therapy for relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and to identify predictors for response and survival, we retrospectively analyzed data of 154 patients with acute myeloid leukemia (AML, n = 124), myelodysplastic (MDS, n = 28), or myeloproliferative syndrome (n = 2).	25540937
TCL4 gene, Aggressive course	Stem Cell Exhaustion	A retrospective analysis of treatment outcomes in adult T cell leukemia/lymphoma patients with aggressive disease treated with or without allogeneic stem cell transplantation: A single-center experience.	25542158
TRPV6 wt Allele	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been reported as a curative treatment modality for ATL.	25542158
Hemopoietic stem cell transplant	Stem Cell Exhaustion	The aim of this study was to assess the prevalence of PDDIs that occur in HSCT patients on the day of hematopoietic stem cell infusion.	25542268
Viral respiratory infection	Stem Cell Exhaustion	Community respiratory virus infection in hematopoietic stem cell transplantation recipients and household member characteristics.	25542323
Atherosclerosis, Dental Plaque, Ischemic stroke	Stem Cell Exhaustion	The relationships between the number of circulating endothelial cells (CECs) or endothelial progenitor cells (EPCs) and indicators of carotid atherosclerosis, such as the intima-media thickness (IMT) and plaque score are not well characterized in patients with chronic ischemic stroke.	25542764
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	In this study, the role of T cells expressing CD161 as a predictor for the occurrence of acute graft-versus-host disease (aGVHD) after allogeneic stem cell transplantation (SCT) was investigated.	25543092
Acute Cholecystitis	Stem Cell Exhaustion	Acute cholecystitis is a common complication after allogeneic stem cell transplantation and is associated with the use of total parenteral nutrition.	25543093
Acute Cholecystitis, Allogeneic Hematopoietic Stem Cell Transplantation	Stem Cell Exhaustion	The incidence and risk factors for acute cholecystitis after allogeneic hematopoietic stem cell transplantation (HSCT) are not well defined.	25543093
Chemotherapy-Induced Febrile Neutropenia	Stem Cell Exhaustion	One hundred seventy consecutive patients with a recent history of chemotherapy-induced neutropenia (n = 100) or allogeneic stem cell recipients (n = 70) who had received a CT scan of the chest in search of pulmonary IFD were examined.	25544029
Pseudomonas aeruginosa, Communicable Diseases	Stem Cell Exhaustion	Fecal colonization and infection with Pseudomonas aeruginosa in recipients of allogeneic hematopoietic stem cell transplantation.	25546740
Pseudomonas aeruginosa	Stem Cell Exhaustion	Pseudomonas aeruginosa, especially multidrug-resistant (MDR) isolates, is an important pathogen in allogeneic hematopoietic stem cell transplant (HCT) recipients.	25546740
Neoplasms, Angiomyofibroblastoma	Stem Cell Exhaustion	Thus, our case of angiomyofibroblastoma is an example of tumor that probably derives from perivascular stem cells that acquire some of myoid features.	25546934
Neoplasms	Stem Cell Exhaustion	Myeloid-derived suppressor cells (MDSCs) are heterogeneous, immature, myeloid progenitor cells, which suppress immune responses against tumors.	25548095
Thrombasthenia	Stem Cell Exhaustion	Use of allogeneic stem cell transplantation for moderate-severe Glanzmann thrombasthenia.	25548835
Specialty Type - cancer, Colorectal Carcinoma, Neoplasms	Stem Cell Exhaustion	Cancer stem cell marker in circulating tumor cells: expression of CD44 variant exon 9 is strongly correlated to treatment refractoriness, recurrence and prognosis of human colorectal cancer.	25550556
Colorectal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	The expression of the CD44 variant exon 9 (CD44v9) was investigated in order to elucidate its significance for cancer stem cells in circulating human colorectal cancer cells (CTCs).	25550556
MYELODYSPLASTIC SYNDROME, Secondary Acute Myeloid Leukemia	Stem Cell Exhaustion	Impact of the revised International Prognostic Scoring System, cytogenetics and monosomal karyotype on outcome after allogeneic stem cell transplantation for myelodysplastic syndromes and secondary acute myeloid leukemia evolving from myelodysplastic syndromes: a retrospective multicenter study of the European Society of Blood and Marrow Transplantation.	25552702
MYELODYSPLASTIC SYNDROME, Secondary Acute Myeloid Leukemia	Stem Cell Exhaustion	The aim of this study was to determine the impact of the revised 5-group International Prognostic Scoring System cytogenetic classification on outcome after allogeneic stem cell transplantation in patients with myelodysplastic syndromes or secondary acute myeloid leukemia who were reported to the European Society for Blood and Marrow Transplantation database.	25552702
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	The revised International Prognostic Scoring System cytogenetic classification allows patients with myelodysplastic syndromes to be separated into three groups with clearly different outcomes after stem cell transplantation.	25552702
Graft-vs-Host Disease	Stem Cell Exhaustion	These phase I data support the safety of stromal stem cell therapy and suggest that MAPC should be tested prospectively as a novel therapeutic option for GVHD prophylaxis after HCT.	25555450
Acute GVH disease	Stem Cell Exhaustion	Single and multiple dose MultiStem (multipotent adult progenitor cell) therapy prophylaxis of acute graft-versus-host disease in myeloablative allogeneic hematopoietic cell transplantation: a phase 1 trial.	25555450
Neoplasms	Stem Cell Exhaustion	The druggable orphan nuclear receptor TLX (NR2E1) is characterized as an important regulator of neural stem cells and is also implicated in the development of some brain tumours.	25557355
Adult Glioblastoma	Stem Cell Exhaustion	Immunophenotypic characterization of human glioblastoma stem cells: correlation with clinical outcome.	25559650
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Recently, glioma stem cells have been identified as the main cause of glioma propagation and recurrence and a number of several cell markers have been indicated as putative GSC markers.	25559650
Adult Glioblastoma	Stem Cell Exhaustion	b-tubulin III, nestin, CD133, GFAP, and SOX-2 marker expression, both in primary GBM cultures and in respective glioblastoma stem cells (GSCs), was evaluated by flow cytometric analysis.	25559650
hepatitis B virus, Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Circulating tumor and cancer stem cells in hepatitis C virus-associated liver disease.	25561791
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	To assess the role of circulating tumor cells (CTCs) and cancer stem cells (CSCs) in hepatitis C virus (HCV)-associated liver disease.	25561791
Leukemia, Myelocytic, Acute, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Granulocyte colony-stimulating factor-primed bone marrow: an excellent stem-cell source for transplantation in acute myelocytic leukemia and chronic myelocytic leukemia.	25563308
Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Autologous stem cell transplant (ASCT) after high-dose chemotherapy (HDT) increases overall survival when used in relapsed non-Hodgkin lymphoma (NHL) in patients under 65 years old.	25563428
Carcinogenesis	Stem Cell Exhaustion	Current models of carcinogenesis are dominated by the assumption that oncogenic mutations have defined advantageous fitness effects on recipient stem and progenitor cells, promoting and rate-limiting somatic evolution.	25564763
Graft-vs-Host Disease	Stem Cell Exhaustion	The outcomes of unrelated stem cell transplantation (SCT) have improved with the use of anti-thymocyte globulin (ATG) to prevent graft-versus-host disease (GVHD) and graft rejection.	25564881
Mastocytosis	Stem Cell Exhaustion	Molecular profiling of myeloid progenitor cells in multi-mutated advanced systemic mastocytosis identifies KIT D816V as a distinct and late event.	25567135
Mastocytosis	Stem Cell Exhaustion	To explore the molecular profile and its prognostic implication in systemic mastocytosis (SM), we analyzed the mutation status of granulocyte-macrophage colony-forming progenitor cells (CFU-GM) in patients with KIT D816V(+) indolent SM (ISM, n=4), smoldering SM (SSM, n=2), aggressive SM (ASM, n=1), SM with associated clonal hematologic non-mast cell lineage disorder (SM-AHNMD, n=5) and ASM-AHNMD (n=7).	25567135
Ischemia	Stem Cell Exhaustion	Effect of repetitive intra-arterial infusion of bone marrow mononuclear cells in patients with no-option limb ischemia: the randomized, double-blind, placebo-controlled Rejuvenating Endothelial Progenitor Cells via Transcutaneous Intra-arterial Supplementation (JUVENTAS) trial.	25567765
Ischemia	Stem Cell Exhaustion	The Rejuvenating Endothelial Progenitor Cells via Transcutaneous Intra-arterial Supplementation (JUVENTAS) trial is a randomized, double-blind, placebo-controlled clinical trial in 160 patients with severe, nonrevascularizable limb ischemia.	25567765
Primary central nervous system lymphoma	Stem Cell Exhaustion	R-MPV followed by high-dose chemotherapy with TBC and autologous stem-cell transplant for newly diagnosed primary CNS lymphoma.	25568347
Encephalopathy, CTCAE 5.0	Stem Cell Exhaustion	An 18-month-old boy developed encephalopathy, for which extensive investigation failed to identify an etiology, 6 weeks after stem cell transplant.	25572899
Multiple Myeloma	Stem Cell Exhaustion	A Phase II trial of weekly bortezomib and dexamethasone in veterans with newly diagnosed multiple myeloma not eligible for or who deferred autologous stem cell transplantation.	25572917
Multiple Myeloma	Stem Cell Exhaustion	We report a phase II trial of alternate dosing and schedule of bortezomib and dexamethasone in newly diagnosed multiple myeloma patients who are not eligible for or refused autologous stem cell transplantation.	25572917
Dislocations	Stem Cell Exhaustion	It is hypothesized to result from the dislocation of small osseous fragments from the xiphoid or os pubis as well as from osteogenic differentiation of local mesenchymal progenitor cells.	25572973
Multiple Myeloma	Stem Cell Exhaustion	Absolute lymphocyte count as predictor of overall survival for patients with multiple myeloma treated with single autologous stem cell transplant.	25573201
Hematologic Neoplasms	Stem Cell Exhaustion	Post-autologous stem cell transplant (ASCT) studies have demonstrated that absolute lymphocyte count (ALC) recovery is associated with prolonged survival in some hematological malignancies.	25573201
Ischemia	Stem Cell Exhaustion	Epigenetic profile of human adventitial progenitor cells correlates with therapeutic outcomes in a mouse model of limb ischemia.	25573856
Ischemia	Stem Cell Exhaustion	We investigated the association between the functional, epigenetic, and expressional profile of human adventitial progenitor cells (APCs) and therapeutic activity in a model of limb ischemia.	25573856
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Causes of discontinuation were disease transformation (7), progressive CLL (7), stem cell transplantation (3), adverse events (11), serious adverse events/deaths (3), and miscellaneous reasons (2).	25573991
Cardiac complication	Stem Cell Exhaustion	Levels of the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) are elevated and endothelial progenitor cells (EPCs) decreased in patients undergoing renal transplantation (Tx) and may contribute to cardiovascular complications.	25576240
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Beta-2 microglobulin predicts the outcome after autologous stem cell transplantation in non-Hodgkin lymphoma.	25577449
Lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) is an established therapeutic modality in the treatment of lymphomas, especially in the relapse setting.	25577449
Allogeneic Hematopoietic Stem Cell Transplantation, Infection of bloodstream	Stem Cell Exhaustion	Risk factors for pre- and post-engraftment bloodstream infections after allogeneic hematopoietic stem cell transplantation.	25580541
Behavioral Symptoms Index Composite Score (BASC-2), Infection of bloodstream	Stem Cell Exhaustion	Bloodstream infections (BSI) are frequently observed after allogeneic hematopoietic stem cell transplant (HSCT), and could cause morbidity and mortality.	25580541
Neoplasms	Stem Cell Exhaustion	Metabolite profiles of 42 GSC lines established from the tumor tissue of adult GBM patients were screened with (1) H NMR spectroscopy and compared with human neural progenitor cells from human adult olfactory bulb (OB-NPCs) and from the developing human brain (HNPCs).	25581615
NCI CTEP SDC AIDS-related Lymphoma Sub-Category Terminology	Stem Cell Exhaustion	Autograft HIV-DNA load predicts HIV-1 peripheral reservoir after stem cell transplantation for AIDS-related lymphoma patients.	25581618
HIV-1 Infection Pathway, Lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) is a widely used procedure for AIDS-related lymphomas, and it represents an opportunity to evaluate strategies curing HIV-1 infection.	25581618
Toxoplasmosis, Cerebral	Stem Cell Exhaustion	Cerebral toxoplasmosis in an adolescent post allogeneic hematopoietic stem cell transplantation: successful outcome by antiprotozoal chemotherapy and CD4+ T-lymphocyte recovery.	25581774
Opportunistic Infections, T-lymphocyte deficiency, Toxoplasmosis	Stem Cell Exhaustion	Toxoplasmosis is a rare opportunistic infection in pediatric allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients and associated with severe T-cell deficiency.	25581774
Childhood Non-Hodgkin Lymphoma, Toxoplasmosis, Cerebral	Stem Cell Exhaustion	Here, we report the successful management of cerebral toxoplasmosis in a 15-year-old adolescent 4 months post allo-HSCT for non-Hodgkin lymphoma through rapid invasive diagnostics, long-term antiprotozoal chemotherapy, and an hematopoietic stem cell boost for persistently poor graft function.	25581774
Helicobacter-associated gastritis	Stem Cell Exhaustion	Influence of prostate stem cell antigen gene polymorphisms on susceptibility to Helicobacter pylori-associated diseases: a case-control study.	25582162
Duodenal Ulcer, Malignant neoplasm of stomach	Stem Cell Exhaustion	Recently, the prostate stem cell antigen (PSCA) rs2294008 C>T polymorphism was found to be associated with different pathogenesis of duodenal ulcer and gastric cancer developments.	25582162
Trichoepithelioma	Stem Cell Exhaustion	The follicular germinative cells observed in the papillary projections and in the aggregations of trichoblastoma expressed cytokeratin-15 (clone C8/144B) and PHLDA1, markers of follicular stem cells.	25583250
TCL6 gene, Specialty Type - cancer	Stem Cell Exhaustion	Similar changes were noted across all cancer types, with highest rates of immunization in leukemia/lymphoma patients (86.8%) and lowest in patients after stem cell transplant (66.7%).	25583919
Colorectal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Aldehyde dehydrogenase 1: a specific cancer stem cell marker for human colorectal carcinoma.	25585687
Colorectal Carcinoma, Cytogenetic Complete Response	Stem Cell Exhaustion	According to the stem cell (SC) theory, colorectal carcinoma (CRC) SCs may be derived from mutations in normal intestinal cells.	25585687
Cytogenetic Complete Response	Stem Cell Exhaustion	Thus, through a shared stem cell marker between CSCs and SCs, it is possible to investigate the association between its expression and the various clinicopathological features in patients with CRC.	25585687
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Since the identification of cancer stem cells (CSCs) a new understanding of tumor occurrence and development has evolved.	25585687
B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative	Stem Cell Exhaustion	Role of allogeneic stem cell transplantation in adult patients with Ph-negative acute lymphoblastic leukemia.	25587040
leukemia, BCR gene	Stem Cell Exhaustion	Because a pediatric-inspired Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) protocol yielded a markedly improved outcome in adults with Philadelphia chromosome-negative ALL, we aimed to reassess the role of allogeneic stem cell transplantation (SCT) in patients treated in the GRAALL-2003 and GRAALL-2005 trials.	25587040
Acute lymphocytic leukemia, Intrinsic Factor Deficiency, Mycoses, BCR gene	Stem Cell Exhaustion	Patients with acute lymphoblastic leukaemia (ALL) after cytotoxic chemotherapy or haematopoietic stem cell transplantation (HSCT) are at risk for life-threatening invasive fungal disease (IFD).	25590660
Cardiomyopathy, Familial Idiopathic	Stem Cell Exhaustion	Autologous transplantation of bone marrow adult stem cells for the treatment of idiopathic dilated cardiomyopathy.	25590932
Mitral Valve Insufficiency, Cardiomyopathy, Familial Idiopathic	Stem Cell Exhaustion	Determine the effectiveness of autologous transplantation of bone marrow adult stem cells on systolic and diastolic left ventricular function, and on the degree of mitral regurgitation in patients with dilated idiopathic cardiomyopathy in functional classes NYHA II and III.	25590932
Cardiomyopathy, Familial Idiopathic	Stem Cell Exhaustion	We administered 4,54 x 10(8) +- 0,89 x 10(8) bone marrow adult stem cells into the coronary arteries of 24 patients with dilated idiopathic cardiomyopathy in functional classes NYHA II and III.	25590932
Ischemic cardiomyopathy	Stem Cell Exhaustion	Effect of aging on human mesenchymal stem cell therapy in ischemic cardiomyopathy patients.	25593053
Ischemic cardiomyopathy, between breakfast and lunch	Stem Cell Exhaustion	The role of patient age in the efficacy of mesenchymal stem cell (MSC) therapy in ischemic cardiomyopathy (ICM) is controversial.	25593053
Heart failure, between breakfast and lunch	Stem Cell Exhaustion	Patients with ICM who received MSCs via transendocardial stem cell injection (TESI) as part of the TAC-HFT (Transendocardial Autologous Cells in Ischemic Heart Failure) (n = 19) and POSEIDON (Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis) (n = 30) clinical trials were divided into 2 age groups: younger than 60 and 60 years of age and older.	25593053
Cerebral Palsy	Stem Cell Exhaustion	Intrathecal injection of CD133-positive enriched bone marrow progenitor cells in children with cerebral palsy: feasibility and safety.	25593079
Multiple Myeloma	Stem Cell Exhaustion	A serum microRNA signature associated with complete remission and progression after autologous stem-cell transplantation in patients with multiple myeloma.	25593199
Morular Metaplasia of the Endometrium, Multiple Myeloma, Gammopathy	Stem Cell Exhaustion	We have examined serum microRNA expression in multiple myeloma (MM) patients at diagnosis and at complete response (CR) after autologous stem-cell transplantation (ASCT), in patients with stable monoclonal gammopathy of undetermined significance, and in healthy controls.	25593199
Retinal Pigments	Stem Cell Exhaustion	Defined culture of human embryonic stem cells and xeno-free derivation of retinal pigmented epithelial cells on a novel, synthetic substrate.	25593208
Metabolic Syndrome X	Stem Cell Exhaustion	Aerobic exercise modulation of mental stress-induced responses in cultured endothelial progenitor cells from healthy and metabolic syndrome subjects.	25596018
Clostridium difficile enteritis	Stem Cell Exhaustion	C. difficile screening was performed on patients admitted for chemotherapy or haematopoietic stem cell transplantation between 2009 and 2013.	25596117
Central Diabetes Insipidus	Stem Cell Exhaustion	The incidence of CDI did not differ between patients receiving chemotherapy and those receiving haematopoietic stem cell transplantation.	25596117
Lymphoma	Stem Cell Exhaustion	For younger patients with relapsed or refractory lymphomas who respond to salvage therapy, autologous stem cell trans- plantation(ASCT)is the standard of care.	25596679
Ph-Like Acute Lymphoblastic Leukemia	Stem Cell Exhaustion	He had a history of BCR-ABL-positive acute lymphoblastic leukemia and had undergone an allogenic stem cell transplantation.	25597932
Colorectal Carcinoma	Stem Cell Exhaustion	Increased pre-surgical numbers of endothelial progenitor cells and circulating endothelial cells in colorectal cancer fail to predict outcome.	25598043
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic stem cell transplantation for refractory acute myeloid leukemia: a single center analysis of long-term outcome.	25598394
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	For patients with refractory acute myeloid leukemia (AML), allogeneic stem cell transplantation (alloSCT) represents the only curative approach.	25598394
Sepsis	Stem Cell Exhaustion	Severe sepsis in hematopoietic stem cell transplant recipients*.	25599465
Infection, Immunocompromised Host	Stem Cell Exhaustion	Hematopoietic stem cell transplant recipients are more likely to be immunocompromised and are predisposed to serious infections.	25599465
Sepsis	Stem Cell Exhaustion	We compared outcomes of hematopoietic stem cell transplant recipients with severe sepsis during engraftment and subsequent admissions with a non-hematopoietic stem cell transplant cohort and excluded solid-organ transplantation from this cohort.	25599465
Sepsis	Stem Cell Exhaustion	We used mixed effect, multivariate logistic regression modeling with propensity score adjustment to examine factors associated with mortality of severe sepsis in hematopoietic stem cell transplant recipients.	25599465
Sepsis	Stem Cell Exhaustion	A total of 21,898 hematopoietic stem cell transplant recipients with severe sepsis were identified.	25599465
Sepsis	Stem Cell Exhaustion	The frequency of severe sepsis in hematopoietic stem cell transplant recipients was five times higher when compared with the non-hematopoietic stem cell transplant cohort.	25599465
Graft-vs-Host Disease	Stem Cell Exhaustion	The unadjusted mortality was 32.9% in non-hematopoietic stem cell transplant cohort, which was similar to autologous hematopoietic stem cell transplant recipients (30.1%) and those who did not develop graft-versus-host disease (35%).	25599465
Graft-vs-Host Disease	Stem Cell Exhaustion	Similarly, in subsequent admissions, hematopoietic stem cell transplant recipients with graft-versus-host disease (odds ratio, 2.14; 95% CI, 1.88-2.45) and without graft-versus-host disease (odds ratio, 1.35; 95% CI, 1.19-1.54) had significantly higher odds of mortality than non-hematopoietic stem cell transplant patients.	25599465
Graft-vs-Host Disease	Stem Cell Exhaustion	Among patients with hematopoietic stem cell transplant, persons with autologous hematopoietic stem cell transplant and those without graft-versus-host disease fared better as compared with their allogeneic and graft-versus-host disease counterparts.	25599465
Sepsis	Stem Cell Exhaustion	Hematopoietic stem cell transplant recipients are more likely to develop severe sepsis and die following a severe sepsis episode than nontransplant patients.	25599465
Graft-vs-Host Disease	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplant recipients and those who do not develop graft-versus-host disease have significantly better outcomes than allogeneic and graft-versus-host disease patients.	25599465
Childhood Breast Carcinoma	Stem Cell Exhaustion	Aldehyde dehydrogenase 1 (ALDH1) is a marker of breast cancer stem cells, and the expression of ALDH1 may be a prognostic factor of poor clinical outcome.	25599843
Hematopoietic Neoplasms, Bone Marrow, Extramedullary Hematopoiesis Function, Primary Myelofibrosis	Stem Cell Exhaustion	Myelofibrosis is a haematopoietic stem cell neoplasm characterized by bone marrow inflammation, reactive marrow fibrosis and extramedullary haematopoiesis.	25601337
Graft-vs-Host Disease	Stem Cell Exhaustion	Onset of ocular graft-versus-host disease symptoms after allogeneic hematopoietic stem cell transplantation.	25603230
Graft-vs-Host Disease	Stem Cell Exhaustion	To study the factors affecting the time to onset of ocular graft-versus-host disease (GVHD) in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT).	25603230
Retinal Pigments	Stem Cell Exhaustion	Canonical/b-catenin Wnt pathway activation improves retinal pigmented epithelium derivation from human embryonic stem cells.	25604686
Retinal Pigments	Stem Cell Exhaustion	The purpose of this study was to better understand the role canonical/b-catenin Wnt signaling plays in the differentiation of human embryonic stem cells (hESCs) into retinal pigmented epithelium (RPE), with the goal of improving methods for derivation.	25604686
Specialty Type - cancer	Stem Cell Exhaustion	Previous studies demonstrated that a subpopulation of cancer cells, which are CD133 positive (CD133+) feature higher invasive and metastatic abilities, are called cancer stem cells (CSCs).	25605013
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Dysfunction of B cells that maintain homeostasis may play a role in the pathogenesis of chronic graft-versus-host disease (cGVHD) after allogeneic stem cell transplantation.	25605369
Birth Injuries, Hypoxia-Ischemia, Brain	Stem Cell Exhaustion	Brain hypoxia-ischemia is a human neonatal injury that is considered a candidate for stem cell therapy.	25605487
Hypoxia-Ischemia, Brain, Carotid artery occlusion	Stem Cell Exhaustion	The possible therapeutic potential of human umbilical cord blood (HUCB) stem cells was evaluated in 14-day-old rats subjected to the right common carotid occlusion, a model of neonatal brain hypoxia-ischemia.	25605487
Neurologic Deficits, Hypoxia-Ischemia, Brain	Stem Cell Exhaustion	The results show the potential of HUCB stem cells in reduction of neurologic deficits associated with neonatal hypoxia-ischemia.	25605487
Childhood Non-Hodgkin Lymphoma, Hereditary hemochromatosis	Stem Cell Exhaustion	We present a 64-year-old white man with non-Hodgkin lymphoma treated with high-dose chemotherapy and stem cell transplant that was subsequently diagnosed with hereditary hemochromatosis.	25608173
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Cytokine expression patterns and mesenchymal stem cell karyotypes from the bone marrow microenvironment of patients with myelodysplastic syndromes.	25608238
PAFAH1B1 wt Allele, Cessation of life, Stem Cell Factor, leukemia, Tumor necrosis	Stem Cell Exhaustion	Compared with the control group, leukemia inhibitory factor, stem cell factor (SCF), stromal cell-derived factor (SDF-1), bone morphogenetic protein 4, hematopoietic stem cell (HSC) stimulating factor, and transforming growth factor-b in the MDS group were significantly downregulated (P<0.05), while interferon-g (IFN-g), tumor necrosis factor-a (TNF-a), and programmed death ligand (B7-H1) were significantly upregulated (P<0.05).	25608238
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Chromosome Aberrations	Stem Cell Exhaustion	The purpose of this study was to explore cytokine expression patterns and cytogenetic abnormalities of mesenchymal stem cells (MSCs) from the bone marrow microenvironment of Chinese patients with myelodysplastic syndromes (MDS).	25608238
Ischemia	Stem Cell Exhaustion	Bone-marrow-derived very small embryonic-like stem cells in patients with critical leg ischaemia: evidence of vasculogenic potential.	25608764
Tissue injury	Stem Cell Exhaustion	Very small embryonic-like stem cells (VSELs) are multipotent stem cells localised in adult bone marrow (BM) that may be mobilised into peripheral blood (PB) in response to tissue injury.	25608764
Bisphosphonate-Associated Osteonecrosis of the Jaw	Stem Cell Exhaustion	Evaluation of the therapeutic effects of conditioned media from mesenchymal stem cells in a rat bisphosphonate-related osteonecrosis of the jaw-like model.	25613174
melanoma	Stem Cell Exhaustion	The purpose of this study was to investigate the expression profile of EZH2 and H3K4me2 and H3K27me3, which constitute stem cell-like "bivalent" domains, in cutaneous malignant melanoma.	25614949
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Our results suggest the possibility that combined immunohistochemical expression of EZH2, H3K4me2, and H3K27me3 might identify cancer cells with potential stem cell properties, particularly at the IF of this malignancy.	25614949
Specialty Type - cancer, Carcinogenesis	Stem Cell Exhaustion	Cancer stem cells and the misregulation of epigenetic modifications have been identified to possess a determinative role in carcinogenesis.	25614949
Multiple Myeloma	Stem Cell Exhaustion	So far long-lived plasma cells can only be depleted by immunoablative therapy with antithymocyte globulin in the setting of stem cell transplantation or by treatment with proteasome inhibitors approved for multiple myeloma.	25616773
Graft-vs-Host Disease, Steroid-Refractory Pneumonitis	Stem Cell Exhaustion	We performed a retrospective study to identify pretransplantation risk factors for steroid-refractory (SR) acute graft-versus host disease (aGVHD) after allogeneic stem cell transplantation from matched donors in 630 adult patients who underwent transplantation at our center between 2000 and 2012.	25617807
Experimental Autoimmune Encephalomyelitis	Stem Cell Exhaustion	Administration of embryonic stem cell-derived thymic epithelial progenitors expressing MOG induces antigen-specific tolerance and ameliorates experimental autoimmune encephalomyelitis.	25618825
Liver Dysfunction, Hepatitis B	Stem Cell Exhaustion	We present a case of severe hepatic dysfunction due to Hepatitis B and sirolimus toxicity, in a 51-year-old male stem cell transplant recipient.	25619898
Cerebrovascular accident, Acute myocardial infarction	Stem Cell Exhaustion	Mobilization of endothelial progenitor cells in acute cardiovascular events in the PROCELL study: time-course after acute myocardial infarction and stroke.	25619946
Electrocardiogram: myocardial infarction (finding), Inflammation, Corneal Endothelial Cell Loss, Venous Stroke	Stem Cell Exhaustion	The aim of our study was to characterize and compare the short- and long-term mobilization of endothelial progenitor cells and circulating endothelial cells after acute myocardial infarction or atherothrombotic stroke, and to determine the relationship between these cell counts and plasma concentrations of vascular cell adhesion molecule (VCAM-1) and Von Willebrand factor (VWF) as surrogate markers of endothelial damage and inflammation.	25619946
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Myocardial infarction patients had higher counts of endothelial progenitor cells and circulating endothelial cells than the controls (201.0/mL vs. 57.0/mL; p<0.01 and 181.0/mL vs. 62.0/mL; p<0.01).	25619946
Cerebrovascular accident	Stem Cell Exhaustion	In stroke patients, the number of endothelial progenitor cells - but not circulating endothelial cells - was higher than in controls (90.0/mL vs. 37.0/mL; p=0.01; 105.0/mL vs. 71.0/mL; p=0.11).	25619946
Cerebrovascular accident	Stem Cell Exhaustion	At 30 days after stroke, however, VCAM-1 peaked (628.1/mL vs. 869.1/mL; p<0.01) but there was no significant change in endothelial progenitor cells (90/mL vs. 78/mL; p<0.34).	25619946
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Cultured endothelial progenitor cells from controls and myocardial infarction patients had endothelial phenotype characteristics and exhibited functional differences in adhesion and Ca(2+) influx, but not in proliferation and vasculogenesis.	25619946
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	In myocardial infarction patients, VCAM-1 levels and mobilization of endothelial progenitor cells peaked at 30 days after the ischemic event.	25619946
Cerebrovascular accident	Stem Cell Exhaustion	Although a similar VCAM-1 kinetic was observed in stroke patients, endothelial progenitor cells did not increase.	25619946
Neoplasms	Stem Cell Exhaustion	The approach consisted in comparing phenotype profile of CTCs, and their progenitor Tumour Stem Cells, (TSCs).	25620181
Fungal Colonization, Mycoses	Stem Cell Exhaustion	Amphotericin B deoxycholate nasal spray administered to hematopoietic stem cell recipients with prior fungal colonization of the upper airway passages is associated with low rates of invasive fungal infection.	25620386
Mycoses	Stem Cell Exhaustion	Invasive fungal infections cause major problems during hematopoietic stem cell transplantation (HSCT).	25620386
Cessation of life, Myeloid neoplasm	Stem Cell Exhaustion	Moreover, cytotoxic treatments destroy normal stem cells with intact p53 systems, a problem especially for myeloid neoplasms, as these cells reverse the low blood counts that cause morbidity and death.	25621498
Peripheral Blood Stem Cells	Stem Cell Exhaustion	The median age was 51 years (range, 18 to 74) with 52% undergoing reduced-intensity conditioning and 48% undergoing myeloablative conditioning HSCT with T cell-replete peripheral blood stem cells (93.7%) or marrow (6.4%) grafts.	25623931
Hemopoietic stem cell transplant	Stem Cell Exhaustion	More NC were detected in the age group of children aged under 6 years with high-degree ALL, at higher levels of severity and in patients who had received a haematopoietic stem-cell transplant, all of them with statistically significant differences.	25624086
neurological complication, Hemopoietic stem cell transplant, Acute leukemia	Stem Cell Exhaustion	Neurological complications are common in patients with acute leukaemia, especially in those at a high-risk stage (above all if they are under the age of 6 years) and with haematopoietic stem-cell transplant.	25624086
Colorectal Carcinoma, Malignant tumor of colon, Secondary malignant neoplasm of liver	Stem Cell Exhaustion	Colon cancer stem cell markers CD44 and CD133 in patients with colorectal cancer and synchronous hepatic metastases.	25625240
Colorectal Carcinoma, Specialty Type - cancer, Secondary malignant neoplasm of liver	Stem Cell Exhaustion	CD44 and CD133 mRNA expression as cancer stem cell markers in colorectal cancer were correlated with synchronous hepatic metastases and the clinicopathological factors, including patient survival.	25625240
Comorbidity, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	At present, a standard therapy for de novo multiple myeloma (MM) patients under 65 years old without severe comorbidity is an upfront high dose chemotherapy (HDCT) with MEL200 combined with auto peripheral blood stem cell transplantation (autoPBSCT) after the induction therapy.	25626309
Adult Glioblastoma	Stem Cell Exhaustion	Among miRNAs screened, we found that miR340 expression was decreased in all human GICs and in human glioblastoma tissues, compared with human neural stem cells and normal brain tissues.	25627976
Structure of auricular appendage	Stem Cell Exhaustion	Clinical-scale in vitro expansion preserves biological characteristics of cardiac atrial appendage stem cells.	25630660
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Cardiac atrial appendage stem cells (CASCs) have recently emerged as an attractive candidate for cardiac regeneration after myocardial infarction.	25630660
Specialty Type - cancer	Stem Cell Exhaustion	Upregulation of circulating cancer stem cell marker, DCLK1 but not Lgr5, in chemoradiotherapy-treated colorectal cancer patients.	25631749
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cell (CSC) markers have attracted considerable attention in tumor diagnostic, prognostic, and therapeutic implications.	25631749
Specialty Type - cancer	Stem Cell Exhaustion	Detection of cancer stem cells in circulating blood using cancer stem cell markers has received remarkable attention recently.	25631749
BARRIER, Infection of bloodstream	Stem Cell Exhaustion	The burden of mucosal barrier injury laboratory-confirmed bloodstream infection among hematology, oncology, and stem cell transplant patients.	25632993
BARRIER, Infection of bloodstream	Stem Cell Exhaustion	To evaluate the impact and burden of the new National Healthcare Safety Network surveillance definition, mucosal barrier injury laboratory-confirmed bloodstream infection (MBI-LCBI), in hematology, oncology, and stem cell transplant populations.	25632993
Infection	Stem Cell Exhaustion	Most CLABSIs identified among hematology, oncology, and stem cell transplant patients met MBI-LCBI criteria, and CLABSI prevention efforts did not reduce these infections.	25632993
Primary Myelofibrosis	Stem Cell Exhaustion	Diagnostic value of 18F-FDG-PET/CT for monitoring myelofibrosis after allogeneic stem cell transplantation.	25633515
bone marrow fibrosis, Primary Myelofibrosis	Stem Cell Exhaustion	Myelofibrosis is a rare hematopoietic stem cell neoplasm leading to marked bone marrow fibrosis and ineffective hematopoiesis.	25633515
Primary Myelofibrosis	Stem Cell Exhaustion	A 62-year-old man with myelofibrosis underwent FDG-PET/CT for evaluation of the extent of disease before and after allogeneic stem cell transplantation (SCT).	25633515
Acute leukemia	Stem Cell Exhaustion	T-cell-replete haploidentical transplantation versus autologous stem cell transplantation in adult acute leukemia: a matched pair analysis.	25637051
Acute leukemia	Stem Cell Exhaustion	Adult patients with acute leukemia in need of a transplant but without a genoidentical donor are usually considered upfront for transplantation with stem cells from any other allogeneic source, rather than autologous stem cell transplantation.	25637051
Hyperammonemia	Stem Cell Exhaustion	Fatal hyperammonemia and carbamoyl phosphate synthetase 1 (CPS1) deficiency following high-dose chemotherapy and autologous hematopoietic stem cell transplantation.	25639153
Hyperammonemia, Central neuroblastoma	Stem Cell Exhaustion	We observed severe hyperammonemia (maximum 475 mmol/L) in a 2-year-old male patient, who underwent high-dose chemotherapy with carboplatin, etoposide and melphalan, and autologous hematopoietic stem cell transplantation for a neuroblastoma stage IV.	25639153
Failure, Hyperammonemia	Stem Cell Exhaustion	Moreover, we highlight the need for urgent diagnostic and therapeutic strategies addressing a possible secondary urea cycle failure in future patients with hyperammonemia during chemotherapy and stem cell transplantation.	25639153
Hallopeau-Siemens Disease	Stem Cell Exhaustion	This study has warranted future clinical investigation of USSCs as a novel and universal allogeneic stem cell donor source in selected patients with RDEB.	25640200
Mucocutaneous candidiasis, Hallopeau-Siemens Disease	Stem Cell Exhaustion	Rescue of the mucocutaneous manifestations by human cord blood derived nonhematopoietic stem cells in a mouse model of recessive dystrophic epidermolysis bullosa.	25640200
Childhood Non-Hodgkin Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Stem cell yield in patients with non-Hodgkin lymphoma was lower compared to patients with multiple myeloma.	25641128
Squamous cell carcinoma of the head and neck	Stem Cell Exhaustion	Detection of putative stem cell markers, CD44/CD133, in primary and lymph node metastases in head and neck squamous cell carcinomas.	25641707
Specialty Type - cancer, Squamous cell carcinoma of the head and neck, Secondary malignant neoplasm of lymph node	Stem Cell Exhaustion	Investigators hypothesized that cancer stem cells (CSCs) could play a role in determining cancer progression by metastasizing to cervical lymph node (N+) and then influencing prognosis of head and neck squamous cell carcinomas (HNSCCs) patients.	25641707
Graft-vs-Host Disease	Stem Cell Exhaustion	Survival and graft-versus-host disease in patients receiving peripheral stem cell compared to bone marrow transplantation from HLA-matched related donor: retrospective analysis of 334 consecutive patients.	25645430
Neoplasms	Stem Cell Exhaustion	Patients with this methylation profile harbor messenger RNA-based signatures indicating tumors with progenitor cell features.	25645722
Neoplasms, Squamous cell carcinoma of the head and neck	Stem Cell Exhaustion	Mesenchymal stem cells are enriched in head neck squamous cell carcinoma, correlates with tumour size and inhibit T-cell proliferation.	25647013
Specialty Type - cancer	Stem Cell Exhaustion	Cancer is a multifactorial disease not only restricted to transformed epithelium, but also involving cells of the immune system and cells of mesenchymal origin, particularly mesenchymal stem cells (MSCs).	25647013
Skeletal muscle structure	Stem Cell Exhaustion	The regeneration of muscle tissue has been achieved using multipotent mesenchymal stem cells in mouse models of injured skeletal muscle.	25647308
Becker Muscular Dystrophy	Stem Cell Exhaustion	In the present study, the utility of multipotent human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) in the treatment of Becker muscular dystrophy (BMD), a genetic disease where muscle tissue fails to regenerate, was examined in members from a pedigree affected by BMD.	25647308
Primary granulocytic sarcoma	Stem Cell Exhaustion	Allogeneic Hematopoietic Stem Cell Transplantation as Treatment for Primary Granulocytic Sarcoma of the Breast.	25647745
Mycoses, Communicable Diseases	Stem Cell Exhaustion	Polymicrobial bacterial or fungal infections: incidence, spectrum of infection, risk factors, and clinical outcomes from a large hematopoietic stem cell transplant center.	25648349
Infection	Stem Cell Exhaustion	Infections cause significant morbidity and mortality for patients who undergo hematopoietic stem cell transplantation (HSCT).	25648349
Haiti, Amyloidosis	Stem Cell Exhaustion	Eight of nine patients with AL amyloidosis began chemotherapy prior to HT, six have resumed chemotherapy since HT, and five have undergone autologous stem cell transplantation.	25648766
Lupus Erythematosus, Encephalitis, St. Louis	Stem Cell Exhaustion	Recent studies showed that allogeneic bone marrow (BM)-mesenchymal stem cells transplantation (MSCT) was effective in systemic lupus erythematosus (SLE) patients and lupus-prone mice.	25649549
Hematological Disease	Stem Cell Exhaustion	A total of 150 adult patients with high-risk hematologic diseases who underwent allogeneic hematopoietic stem cell transplantation from alternative donors at 2 centers (Paoli-Calmettes Institute [Marseille, France] and Humanitas Cancer Center [Milan, Italy]) were analyzed.	25649994
Thrombotic Microangiopathies	Stem Cell Exhaustion	Use of Eculizumab in Patients With Allogeneic Stem Cell Transplant-Associated Thrombotic Microangiopathy: A Study From the SFGM-TC.	25651309
Thrombomodulin Alfa, Thrombotic Microangiopathies	Stem Cell Exhaustion	Thrombotic microangiopathy (TMA) occurring after allogeneic hematopoietic stem cell transplantation (HSCT) has a devastating prognosis.	25651309
Hyperglycemia, Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Umbilical cord mesenchymal stem cell transfusion ameliorated hyperglycemia in patients with type 2 diabetes mellitus.	25651730
Chronic graft-versus-host disease	Stem Cell Exhaustion	Recent studies have considered the qualitative and quantitative assessment of salivary flow, as well the biochemical components of saliva, as possible biomarkers that might contribute to the pathogenesis of chronic graft-versus-host disease (cGHVD) in hematopoietic stem cell transplantation (HSCT) patients.	25652148
Glioblastoma Multiforme Pathway, Neoplasms	Stem Cell Exhaustion	This glioma study brings together actions of a normal epigenetic mechanism (JMJD3 activity) with dysfunctional activation of senescence-related processes, including secretion of SASP proinflammatory cytokines and stem cell tropism toward tumors.	25652587
Neoplasms	Stem Cell Exhaustion	These studies are therapeutically relevant because inflammatory cytokines have been linked to homing of neural stem cells and other stem cells to tumor loci.	25652587
T-Cell Lymphoma	Stem Cell Exhaustion	Comparison of survival in patients with T cell lymphoma after autologous and allogeneic stem cell transplantation as a frontline strategy or in relapsed disease.	25652691
RHOJ gene, T-Cell Lymphoma	Stem Cell Exhaustion	We studied the roles of autologous (A) and allogeneic (allo) stem cell transplantation (SCT) in the treatment of 134 patients with T cell lymphoma (TCL) at our center.	25652691
Old age	Stem Cell Exhaustion	The antisenescence effect of trans-cinnamaldehyde on adipose-derived stem cells.	25654692
cinnamic aldehyde, Transcobalamin	Stem Cell Exhaustion	The aim of this study was to demonstrate the capacity of Trans-cinnamaldehyde (TC) in reversing stress-induced senescence and maintaining the quality of stem cells in a chemically (H2O2)-induced cell senescence model.	25654692
Infarction, Middle Cerebral Artery	Stem Cell Exhaustion	We sought to determine MR imaging findings after mesenchymal stem cell implantation in chronic middle cerebral artery infarcts and to compare brain volume changes in patients with mesenchymal stem cells with those in age-matched healthy controls and controls with chronic stable MCA infarcts.	25655873
Volume	Stem Cell Exhaustion	Volumetric analysis showed a trend toward less overall volume loss after mesenchymal stem cell implantation (0.736; 95% CI, -4.15-5.62) compared with that in age- and sex-matched controls with chronic, stable MCA infarcts (-3.59; 95% CI, -12.3 to -5.21; P = .09), with a significantly greater growth-to-loss ratio in infarcted regions (1.30 and 0.78, respectively, P = .02).	25655873
Volume	Stem Cell Exhaustion	Initial findings suggest a trend toward less volume loss after mesenchymal stem cell implantation compared with that in age- and sex-matched controls with chronic, stable MCA infarcts, with a significantly greater growth-to-loss ratio in the infarcted tissue.	25655873
Infarction, Anterior Cerebral Artery	Stem Cell Exhaustion	Qualitative and quantitative analysis of MR imaging findings in patients with middle cerebral artery stroke implanted with mesenchymal stem cells.	25655873
Ischemic stroke	Stem Cell Exhaustion	Mesenchymal stem cells have potential as a regenerative therapy in ischemic stroke.	25655873
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Outcome of Patients With Non-Hodgkin Lymphomas With Concurrent MYC and BCL2 Rearrangements Treated With CODOX-M/IVAC With Rituximab Followed by Hematopoietic Stem Cell Transplantation.	25656914
Epidermolysis Bullosa	Stem Cell Exhaustion	Immunogenicity of decidual stromal cells in an epidermolysis bullosa patient and in allogeneic hematopoietic stem cell transplantation patients.	25658253
Graft-vs-Host Disease, Hemorrhagic cystitis	Stem Cell Exhaustion	Two of 16 allogeneic stem cell-transplanted patients, treated with DSCs for graft-versus-host disease or hemorrhagic cystitis, showed a positive flow cytometric crossmatch test.	25658253
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	The circulating endothelial progenitor cell level (percent of CD45(-)CD34(+) VEGF-R2(+) cells in total peripheral blood mononuclear cells) was quantified in 47 patients with renal cell carcinoma and 40 healthy controls.	25659661
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	The circulating endothelial progenitor cell level was significantly higher in patients with renal cell carcinoma than in healthy controls (0.276% vs 0.086%, p <0.001).	25659661
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Earlier emergence of circulating endothelial progenitor cell colonies, a higher cell culture success rate and more colonies were found for patients with renal cell carcinoma than for healthy controls.	25659661
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Culture and Characterization of Circulating Endothelial Progenitor Cells in Patients with Renal Cell Carcinoma.	25659661
Neoplasms, Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Although emerging evidence demonstrates increased circulating endothelial progenitor cells in patients with solid tumors, to our knowledge it is still unknown whether such cells can be cultured from patients with highly angiogenic renal cell carcinoma.	25659661
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	We cultured and characterized circulating endothelial progenitor cells from patients with renal cell carcinoma.	25659661
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Peripheral blood mononuclear cells were then isolated from 33 patients with renal cell carcinoma and 30 healthy controls to culture and characterize circulating endothelial progenitor cells.	25659661
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	However, significantly more VEGF-R2(+) circulating endothelial progenitor cells were found in preparations from patients with renal cell carcinoma than from healthy controls (21.1% vs 13.4%, p <0.001).	25659661
Have Been Vomiting	Stem Cell Exhaustion	Addition of Aprepitant (Emend(r)) to Standard Antiemetic Regimen Continued for 7 Days after Chemotherapy for Stem Cell Transplantation Provides Significant Reduction of Vomiting.	25659986
Refractory Chemotherapy-Induced Nausea and Vomiting, Chemotherapy-induced Nausea and Vomiting Questionnaire	Stem Cell Exhaustion	Chemotherapy-induced nausea/vomiting (CINV) is a major problem for patients treated with high-dose chemotherapy (HDCT) conditioning before stem cell transplantation (SCT), both during chemotherapy and afterwards (delayed nausea/vomiting).	25659986
Vancomycin-Resistant Enterococci, Fever	Stem Cell Exhaustion	Empiric use of linezolid in febrile hematology and hematopoietic stem cell transplantation patients colonized with vancomycin-resistant Enterococcus spp.	25660090
Amyloidosis	Stem Cell Exhaustion	Extended follow up of high-dose melphalan and autologous stem cell transplantation after vincristine, doxorubicin, dexamethasone induction in amyloid light chain amyloidosis of the prospective phase II HOVON-41 study by the Dutch-Belgian Co-operative Trial Group for Hematology Oncology.	25661441
Amyloidosis	Stem Cell Exhaustion	However, a 2-step approach consisting of a non-intensive less toxic induction therapy followed by high-dose melphalan and autologous stem cell transplantation may result in extended survival in newly diagnosed patients with amyloid light chain amyloidosis (clinicaltrials.gov identifier: 01207094).	25661441
Squamous cell carcinoma	Stem Cell Exhaustion	Voriconazole exposure and the risk of cutaneous squamous cell carcinoma in allogeneic hematopoietic stem cell transplant patients.	25661996
Physical activity decreased	Stem Cell Exhaustion	We conducted the first-regenerative medicine cellular therapy for underactive bladder (UAB) in an FDA-approved, compassionate-use IND trial to evaluate treatment safety and potential clinical efficacy of autologous muscle-derived stem cells (AMDC) on a patient with UAB.	25663053
Nontuberculous Mycobacteria	Stem Cell Exhaustion	The clinical importance of the isolation of nontuberculous mycobacteria (NTM) from respiratory specimens of stem cell transplant (SCT) recipients is not clear.	25663510
Multiple Myeloma	Stem Cell Exhaustion	Immunomodulatory effects of the Agaricus blazei Murrill-based mushroom extract AndoSan in patients with multiple myeloma undergoing high dose chemotherapy and autologous stem cell transplantation: a randomized, double blinded clinical study.	25664323
Multiple Myeloma	Stem Cell Exhaustion	Forty patients with multiple myeloma scheduled to undergo high dose chemotherapy with autologous stem cell support were randomized in a double blinded fashion to receive adjuvant treatment with the mushroom extract AndoSan, containing 82% of Agaricus blazei Murrill (19 patients) or placebo (21 patients).	25664323
Agenesis	Stem Cell Exhaustion	Intake of the study product started on the day of stem cell mobilizing chemotherapy and continued until the end of aplasia after high dose chemotherapy, a period of about seven weeks.	25664323
Crohn Disease, Spondylarthritis	Stem Cell Exhaustion	Lymphatic endothelial progenitor cells and vascular endothelial growth factor-C in spondyloarthritis and Crohn's disease: two overlapping diseases?	25664492
Glioblastoma Multiforme Pathway, Adult Glioblastoma	Stem Cell Exhaustion	Effect of Notch expression in glioma stem cells on therapeutic response to chemo-radiotherapy in recurrent glioblastoma.	25665548
Glioblastoma Multiforme Pathway, Neoplasms	Stem Cell Exhaustion	Glioma stem cells (GSCs) have the capacity to repopulate tumors and mediate resistance to radiotherapy and chemotherapy.	25665548
CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology	Stem Cell Exhaustion	Antithymocyte globulin (ATG) is the drug of choice for immunosuppressive therapy (IST) in patients with SAA ineligible for allogeneic stem cell transplantation.	25666078
Malignant neoplasm of lung	Stem Cell Exhaustion	KRAS mutations (codons 12/13) were found to be a biomarker of radiosensitization by midostaurin in lung cancer, which was pronounced under conditions that enriched for stem cell-like cells.	25667133
Cessation of life, HIV-1	Stem Cell Exhaustion	g-Herpesvirus load as surrogate marker of early death in HIV-1 lymphoma patients submitted to high dose chemotherapy and autologous peripheral blood stem cell transplantation.	25668032
HIV	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) is a feasible procedure for human immunodeficiency virus-1 (HIV-1) lymphoma patients, whose underlying disease and intrinsic HIV-1- and ASCT-associated immunodeficiency might increase the risk for g-herpesvirus load persistence and/or reactivation.	25668032
Hepatitis B	Stem Cell Exhaustion	However, three anti-HBc/anti-HBs positive patients who were treated with allogeneic hematopoietic stem cell transplantation demonstrated hepatitis B virus reactivation within 12 months from transplant.	25671825
Hepatitis B, Communicable Diseases	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation is a high risk condition for late hepatitis B virus reactivation in patients with resolved infection.	25671825
Osteopetrosis	Stem Cell Exhaustion	Various treatment options have been suggested for osteopetrosis, but hematopoietic stem cell transplantation still remains the only curative treatment option presently.	25673572
melanoma	Stem Cell Exhaustion	Increased expression of melanoma stem cell marker CD271 in metastatic melanoma to the brain.	25674270
melanoma	Stem Cell Exhaustion	Human melanoma contains multipotent stem cells that express the neural crest stem cell marker CD271.	25674270
Primary Myelofibrosis, Myeloproliferation, Hyperplasia	Stem Cell Exhaustion	Myelofibrosis is a rare clonal hematopoietic stem cell disorder characterized by chronic myeloproliferation, atypical megakaryocytic hyperplasia, and potential leukemic transformation.	25674874
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	HLA-matched allogeneic stem cell transplantation improves outcome of higher risk myelodysplastic syndrome A prospective study on behalf of SFGM-TC and GFM.	25676424
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HSCT) is considered the only a curative treatment in patients with higher risk myelodysplastic syndrome (MDS), although demethylating agents (DMA) have been reported to improve survival.	25676424
Pudendal Neuralgia	Stem Cell Exhaustion	The aim of this prospective study was to investigate the feasibility and report the short-term results of a new procedure for treatment of pudendal neuralgia, consisting of transperineal injections of autologous adipose tissue with stem cells along the Alcock's canal.	25677417
Specialty Type - cancer, Metaplastic carcinoma of breast	Stem Cell Exhaustion	Cancer stem cell and epithelial-mesenchymal transition markers predict worse outcome in metaplastic carcinoma of the breast.	25677743
Specialty Type - cancer	Stem Cell Exhaustion	Antibodies to ER, PR, HER2, CK14, EGFR, 34bE12, cancer stem cell markers (CD44, CD24, ALDH1A1), epithelial-mesenchymal transition markers (Twist and E-cadherin), were applied.	25677743
Malignant neoplasm of breast, Specialty Type - cancer	Stem Cell Exhaustion	Expression of cancer stem cell and epithelial-mesenchymal transition markers in metaplastic breast cancers correlates with adverse pathological parameters and outcome.	25677743
Metaplastic carcinoma of breast, Specialty Type - cancer	Stem Cell Exhaustion	Metaplastic breast carcinomas are known to overexpress markers of epithelial-mesenchymal transition and cancer stem cells.	25677743
Malignant neoplasm of stomach, Specialty Type - cancer	Stem Cell Exhaustion	5-Fluorouracil chemotherapy of gastric cancer generates residual cells with properties of cancer stem cells.	25678847
Specialty Type - cancer	Stem Cell Exhaustion	Emerging evidence suggests that the existence of cancer stem cells (CSCs) contributes to chemoresistance.	25678847
Alzheimers Disease	Stem Cell Exhaustion	Prostate stem cell antigen interacts with nicotinic acetylcholine receptors and is affected in Alzheimer's disease.	25680266
Thrombocytopenia due to platelet alloimmunization, Hematopoietic stem cells	Stem Cell Exhaustion	We examined the effects of serum and IgG from 19 patients with immune thrombocytopenia using day 8 or 9 megakaryocytes (66.3 +- 10.6% CD41(+)), derived from cord blood hematopoietic stem cells (CD34(+)).	25682608
Neoplasms	Stem Cell Exhaustion	Cells cultured from the tumor show stem cell properties that could contribute to the recurrent tumor growth.	25682776
Hodgkin Disease	Stem Cell Exhaustion	Pre-transplantation (18)F-fluorodeoxyglucose (FDG) PET-negativity is one of the strongest predictors of outcome after high-dose therapy and autologous stem-cell transplant (HDT/ASCT) for patients with relapsed or refractory Hodgkin's lymphoma.	25683846
CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology	Stem Cell Exhaustion	Overall survival (OS) after upfront human leucocyte antigen-matched family donor (MFD) haematopoietic stem cell transplantation (HSCT) or immunosuppressive treatment (IST) was 91% vs. 87% (P 0*18).	25683884
Neoplasms	Stem Cell Exhaustion	The 'transdifferentiation' of NET cells into ductular cells is considered as the most plausible histogenetic mechanism of this tumor, although other possibilities, such as an origin from a primitive endodermal stem cell or the induction of ductular proliferation by stimulation with NET-derived humoral factors, cannot be excluded.	25684418
Hematologic Neoplasms, Myeloproliferative disease, DPM1 gene	Stem Cell Exhaustion	Myeloproliferative disorders (MPDs) are clonal hematologic malignancies originating at the level of the pluripotent hematopoietic stem cell.	25684469
Infection, Aspergillosis	Stem Cell Exhaustion	After hematopoietic stem cell transplantation, invasive aspergillosis remains one of the most lethal infections.	25688598
Multiple Myeloma	Stem Cell Exhaustion	Content of endothelial progenitor cells in autologous stem cell grafts predict survival after transplantation for multiple myeloma.	25689789
Malignant Neoplasms	Stem Cell Exhaustion	Multiple myeloma (MM) is considered an incurable B cell malignancy, although many patients can benefit from high-dose therapy with autologous stem cell transplantation (ASCT) as a first-line treatment.	25689789
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	Here, we investigated the clinical impact of EPC levels in peripheral blood stem cell (PBSC) autografts for MM and NHL patients who received ASCT.	25689789
Mantle cell lymphoma	Stem Cell Exhaustion	Zevalin and BEAM (Z-BEAM) versus rituximab and BEAM (R-BEAM) conditioning chemotherapy prior to autologous stem cell transplantation in patients with mantle cell lymphoma.	25689832
Degenerative disorder of cartilage	Stem Cell Exhaustion	Chondrocyte clusters adjacent to sites of cartilage degeneration have characteristics of progenitor cells.	25691232
Febrile Neutropenia	Stem Cell Exhaustion	The routine use of chest radiographs (CXRs) in the initial evaluation of asymptomatic patients with febrile neutropenia undergoing hematopoietic stem cell transplant (HSCT) is controversial.	25691611
Prostate carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Expression of stem cell marker CD44 in prostate cancer biopsies predicts cancer grade in radical prostatectomy specimens.	25693083
Prostate carcinoma	Stem Cell Exhaustion	We used a stem cell marker CD44 to evaluate the prevalence of prostate cancer stem cells in prostate biopsies and in matched radical prostatectomy specimens.	25693083
Specialty Type - cancer, Adenocarcinoma of prostate	Stem Cell Exhaustion	Cancer stem cells play an important role in development and progression of many cancer types including prostate adenocarcinoma.	25693083
Nerve Degeneration	Stem Cell Exhaustion	Brief report: isogenic induced pluripotent stem cell lines from an adult with mosaic down syndrome model accelerated neuronal ageing and neurodegeneration.	25694335
Prostate carcinoma, Benign prostatic hypertrophy	Stem Cell Exhaustion	Prostate stem cell antigen (PSCA) mRNA expression in peripheral blood in patients with benign prostatic hyperplasia and/or prostate cancer.	25698533
Prostate carcinoma, Passive Cutaneous Anaphylaxis	Stem Cell Exhaustion	The aim of this study was to determine whether detection of prostate stem cell antigen (PSCA) expression in BPH might be associated with the subsequent presence of Prostate cancer (PCa) and also to determine whether detection of PSCA expression has potential for prognosis in PCa.	25698533
Histogenic Process, Carcinoma	Stem Cell Exhaustion	For clarifying the histogenesis, immunophenotypic analysis of the 3 different components of the carcinoma was performed using hair follicle stem cell markers (eg, CK15, CK19, and CD200) that have been identified as biomarkers of human bulge cells.	25699980
Histogenic Process, Merkel cell carcinoma, Sweat gland adenocarcinoma, Hair follicle structure, Carcinoma, Spindle-Cell	Stem Cell Exhaustion	Merkel cell carcinoma with glandular differentiation admixed with sweat gland carcinoma and spindle cell carcinoma: histogenesis of merkel cell carcinoma from hair follicle stem cells.	25699980
Hair follicle structure	Stem Cell Exhaustion	We posit that the MCC arose from hair follicle stem cells residing within the bulge area where Merkel cells are preferentially situated.	25699980
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Accelerated onset of senescence of endothelial progenitor cells in patients with type 2 diabetes mellitus: role of dimethylarginine dimethylaminohydrolase 2 and asymmetric dimethylarginine.	25701782
Juvenile Myelomonocytic Leukemia	Stem Cell Exhaustion	Juvenile myelomonocytic leukemia (JMML) is not durably responsive to chemotherapy, and approximately 50% of patients relapse after hematopoietic stem cell transplant (HSCT).	25704135
B-Cell Lymphomas	Stem Cell Exhaustion	A phase 2 study of inotuzumab ozogamicin and rituximab, followed by autologous stem cell transplant in patients with relapsed/refractory diffuse large B-cell lymphoma.	25707288
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	This study evaluated the safety and efficacy of inotuzumab ozogamicin (INO), a targeted humanized anti-CD22 antibody conjugated to calicheamicin, plus rituximab (R-INO) every 3 weeks, up to six cycles, followed by high dose therapy and autologous stem cell transplant (HDT-aSCT) in patients with high-risk relapsed/refractory diffuse large B-cell lymphoma (DLBCL).	25707288
Multiple Myeloma	Stem Cell Exhaustion	Cord blood has been investigated as an alternative source for hematopoietic stem cell transplantation, but information about its use for multiple myeloma is limited.	25708214
neurological complication	Stem Cell Exhaustion	Neurologic complications after allogeneic hematopoietic stem cell transplantation in children: analysis of prognostic factors.	25708217
neurological complication	Stem Cell Exhaustion	Neurologic complications are serious complications after hematopoietic stem cell transplantation (HSCT) and significantly contribute to morbidity and mortality.	25708217
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic graft-versus-host disease (cGVHD) is a critical complication after allogeneic hematopoietic stem cell transplantation.	25708216
Chronic graft-versus-host disease	Stem Cell Exhaustion	Phenotypical and functional characterization of bone marrow mesenchymal stem cells in patients with chronic graft-versus-host disease.	25708216
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Effect of graft source on unrelated donor hemopoietic stem cell transplantation in adults with acute myeloid leukemia after reduced-intensity or nonmyeloablative conditioning: a study from the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire.	25708220
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This retrospective report compared the 4-year outcomes of allogeneic stem cell transplantation (allo-SCT) in 651 adult patients with acute myeloid leukemia receiving a reduced-intensity (RIC) or nonmyeloablative conditioning (NMA) regimen according to the type of unrelated donors.	25708220
Hematologic Neoplasms, Virus Diseases	Stem Cell Exhaustion	Cord blood transplantation (CBT) is curative for many patients with hematologic malignancies but is associated with delayed immune recovery and an increased risk of viral infections compared with HLA-matched bone marrow or peripheral blood progenitor cell transplantation.	25708219
Specialty Type - cancer, Carcinoma	Stem Cell Exhaustion	Cancer Stem Cell Markers in Eyelid Sebaceous Gland Carcinoma: High Expression of ALDH1, CD133, and ABCG2 Correlates With Poor Prognosis.	25711631
Eyelid Sebaceous Gland Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	To investigate the expression of cancer stem cell (CSC) marker proteins in eyelid sebaceous gland carcinoma and evaluate the clinical significance.	25711631
MS gene	Stem Cell Exhaustion	High-dose immunosuppressive therapy (HDIT) with autologous hematopoietic stem cell transplantation (AHSCT) is a promising approach to treatment of multiple sclerosis (MS) patients.	25711670
Hematological Disease	Stem Cell Exhaustion	Haematopoietic stem cell transplantation (HSCT) cures many haematological cancers.	25711722
Medial collateral ligament, Toxic effect	Stem Cell Exhaustion	We identified 42 patients with MCL who discontinued therapy due to disease progression on treatment (n = 28), toxicity (n = 6), elective stem-cell transplant in remission (n = 4) or withdrawn consent (n = 4).	25712454
Malignant neoplasm of ovary, Specialty Type - cancer	Stem Cell Exhaustion	VAV3 Overexpressed in Cancer Stem Cells Is a Poor Prognostic Indicator in Ovarian Cancer Patients.	25715123
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells (CSCs) are thought to contribute significantly to disease relapse and drug resistance.	25715123
TRPV6 wt Allele	Stem Cell Exhaustion	Various treatment regimens were applied in EATL during the past fifteen years including either monotherapy consisting of chemotherapy or resection, or combination therapy with both aforementioned regimens whether or not combined with stem-cell transplantation (SCT).	25716069
Gestational Diabetes	Stem Cell Exhaustion	This study provides strong evidence in neonatal endothelial progenitor cells that GDM exposure in utero leads to altered gene expression and DNA methylation, suggesting the possibility of altered epigenetic regulation.	25720387
Hair follicle structure	Stem Cell Exhaustion	We used hair follicle stem cell markers to investigate whether MCC share certain characteristics of these stem cells.	25720654
Hair follicle structure	Stem Cell Exhaustion	In six combined MCC, both MCC components and squamous components at least focally shared the expression of one or more of cytokeratin (CK)15, CK19 and CD200, which are hair follicle stem cell markers.	25720654
Hair follicle structure	Stem Cell Exhaustion	There was a distinct difference between pure MCC and combined MCC on the expression of hair follicle stem cell markers.	25720654
Infection caused by Helicobacter pylori, Duodenal Ulcer, Malignant neoplasm of stomach	Stem Cell Exhaustion	Two recent genome-wide association studies in Asians have reported the association between the PSCA (prostate stem cell antigen) rs2294008C>T gene polymorphism and two Helicobacter pylori infection-related diseases such as gastric cancer (GC) and duodenal ulcer (DU).	25721731
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Somatic mutation of DNMT3A, especially at the Arg882 (R882) site of the DNMT3A coding sequence, has been identified in pre-leukemic stem cell clones as one of the driver mutations of acute myeloid leukemia (AML).	25721756
Hypoglycemia, diabetic	Stem Cell Exhaustion	Hypoglycemia affects the changes in endothelial progenitor cell levels during insulin therapy in type 2 diabetic patients.	25722222
Hypoglycemia	Stem Cell Exhaustion	Though PCs increased at study end, in patients experiencing at least 1 hypoglycemic episode, the changes in CD34(+), CD133(+) progenitor cells and CD34(+)KDR(+) EPCs were significantly lower than the respective changes in patients without incident hypoglycemia, even after correcting for confounders.	25722222
Specialty Type - cancer	Stem Cell Exhaustion	Subsets of long-lived, tumor-initiating stem cells often escape cancer therapies.	25723170
Squamous cell carcinoma	Stem Cell Exhaustion	Here, we devise a functional reporter system to lineage trace and/or genetic ablate signaling in TGF-b-activated squamous cell carcinoma stem cells (SCC-SCs).	25723170
Colorectal Carcinoma, Neoplasms, Pancreatic carcinoma	Stem Cell Exhaustion	Doublecortin-like kinase 1 (DCLK1) is a putative pancreatic stem cell marker and is upregulated in pancreatic cancer, colorectal cancer, and many other solid tumors.	25723399
Neoplasms, Intestinal Neoplasms	Stem Cell Exhaustion	It marks tumor stem cells in mouse models of intestinal neoplasia.	25723399
Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	Given the increasingly recognized role of EMT derived stem cells in cancer progression and metastasis, we hypothesize that DCLK1 may contribute to the metastatic process.	25723399
Primary Myelofibrosis	Stem Cell Exhaustion	CD133 marks a stem cell population that drives human primary myelofibrosis.	25724578
Primary Myelofibrosis	Stem Cell Exhaustion	Here we describe a CD133(+) stem cell population that drives the pathogenesis of primary myelofibrosis.	25724578
Primary Myelofibrosis	Stem Cell Exhaustion	This is the first characterization of a patient-derived stem cell population that drives disease resembling both chronic and acute phases of primary myelofibrosis in mice.	25724578
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	There is increasing evidence that the existence of cancer stem cells (CSC) is responsible for tumour formation and maintenance.	25727099
Exfoliative dermatitis, Omenn Syndrome	Stem Cell Exhaustion	Since extensive erythroderma with generalized itching causes patient discomfort in Omenn syndrome, cyclosporin treatment can be considered while waiting for treatment with hematopoietic stem cell transplantation.	25727345
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Enhanced engraftment and repairing ability of human adipose-derived stem cells, conveyed by pharmacologically active microcarriers continuously releasing HGF and IGF-1, in healing myocardial infarction in rats.	25727843
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	To overcome this drawback, rats with 4-week-old myocardial infarction (MI) were injected in the border zone with human adipose-derived stem cells (ADSCs) conveyed by poly(lactic-co-glycolic acid) microcarriers (PAMs) releasing hepatocyte growth factor (HGF) and insulin-like growth factor-1 (IGF-1) (GFsPAMs).	25727843
Virus Diseases	Stem Cell Exhaustion	Most of the publications report data about stem cell transplant patients, little is known about these virus infections in renal transplant patients.	25728075
Special Handling Code - Dry	Stem Cell Exhaustion	In addition, clinical trials are currently underway outside Japan using human mesenchymal stromal cells and human neural stem cells to protect photoreceptors in RP and dry age-related macular degeneration, respectively.	25728228
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Outcomes in multiple myeloma (MM) have improved significantly with novel agent therapy and autologous stem cell transplantation (ASCT).	25730190
Hodgkin Disease, Relapsing course	Stem Cell Exhaustion	Relapsed or refractory (R/R) classical Hodgkin lymphoma (cHL) after autologous stem cell transplantation (ASCT) remains a challenge.	25734915
Thrombotic Microangiopathies	Stem Cell Exhaustion	Hematopoietic stem cell transplantation-associated thrombotic microangiopathy accompanied by renal arteriolar C4d deposition.	25735190
Mycoses	Stem Cell Exhaustion	Incidence and risk factors of probable and proven invasive fungal infection in adult patients receiving allogeneic hematopoietic stem cell transplantation.	25735797
Mycoses	Stem Cell Exhaustion	To investigate the incidence and risk factors for the occurrence of proven or probable invasive fungal infection (IFI) in adult patients receiving allogeneic hematopoietic stem cell transplantation (HSCT).	25735797
Leukemia, Myelomonocytic, Chronic, PAFAH1B1 wt Allele	Stem Cell Exhaustion	Outcome of patients with high risk MDS and CMML who failed treatment with azacitidine remains poor with a median survival of 6 months, without established therapy available except allogeneic hematopoietic stem cell transplantation.	25735917
Specialty Type - cancer	Stem Cell Exhaustion	We also investigated changes in the CD24(+)/44(+) population that may be involved in chemoresistance, as this population likely includes cancer stem cells.	25736055
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Stem Cell Exhaustion	In this phase 3 trial, we randomly assigned 487 adults with newly diagnosed mantle-cell lymphoma who were ineligible or not considered for stem-cell transplantation to receive six to eight 21-day cycles of R-CHOP intravenously on day 1 (with prednisone administered orally on days 1 to 5) or VR-CAP (R-CHOP regimen, but replacing vincristine with bortezomib at a dose of 1.3 mg per square meter of body-surface area on days 1, 4, 8, and 11).	25738670
Failure, Mantle cell lymphoma, Specialty Type - cancer	Stem Cell Exhaustion	Repeated relapses leading to treatment failure in patients with mantle cell lymphoma might suggest the presence of cancer stem cells.	25739938
Specialty Type - cancer	Stem Cell Exhaustion	A small cell population with CD45+/CD19 - was previously reported to represent cancer stem cells.	25739938
Pulmonary Complication, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Impact of body mass index on pulmonary complications in patients with non-Hodgkin lymphoma treated with hematopoietic stem cell transplant.	25739939
Pulmonary Complication	Stem Cell Exhaustion	The objective of this study was to examine the association between body mass index (BMI) and the incidence of pulmonary complications (PCs) after hematopoietic stem cell transplant (HCT).	25739939
Graft-vs-Host Disease, Stable chronic Graft vs Host Disease, physiopathological	Stem Cell Exhaustion	At least half of patients with chronic graft-versus-host-disease (cGVHD), the leading cause of morbidity and non-relapse mortality after allogeneic stem cell transplantation, have oral manifestations: mucosal lesions, salivary dysfunction, and limited mouth-opening.	25740857
Meningitis	Stem Cell Exhaustion	This report describes a case of meningitis caused by Listeria monocytogenes in a stem cell transplant recipient on immunosuppressive therapy for cutaneous chronic graft-versus host disease.	25742155
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	A 59-year-old woman had undergone allogeneic stem cell transplantation (from a matched unrelated donor) 13 months previously for chronic lymphocytic leukemia.	25742155
Aspergillus Galactomannan Antigen Test	Stem Cell Exhaustion	False-positive Aspergillus galactomannan and its kinetics in allogeneic hematopoietic stem cell transplantation.	25743584
Aspergillus Galactomannan Antigen Test	Stem Cell Exhaustion	We evaluated the incidence of and risk factors for false-positive Aspergillus galactomannan (GM) antigenemia in allogeneic hematopoietic stem cell transplantation (HSCT).	25743584
Cytomegalovirus Infections	Stem Cell Exhaustion	[Usefulness of quantitative PCR in biopsy specimens for early therapeutic intervention in gastro-intestinal cytomegalovirus infections after allogeneic stem cell transplantation].	25744040
Cytomegalovirus Infections	Stem Cell Exhaustion	Gastro-intestinal cytomegalovirus infection (GI-CMV), which occurs after allogeneic stem cell transplantation (allo-SCT), is diagnosed by immunostaining of biopsied tissues obtained using a fiberscope.	25744040
Hypertrophic Cardiomyopathy	Stem Cell Exhaustion	Circulating mesenchymal stem cells in patients with hypertrophic cardiomyopathy.	25744383
Hypertrophic Cardiomyopathy, Health maintenance	Stem Cell Exhaustion	This study examines the mobilization of mesenchymal stem cells (MSCs) in patients with hypertrophic cardiomyopathy (HCM) compared to healthy individuals.	25744383
Interstitial Cystitis	Stem Cell Exhaustion	Mesenchymal Stem Cell Therapy Alleviates Interstitial Cystitis by Activating Wnt Signaling Pathway.	25745847
Multiple Myeloma	Stem Cell Exhaustion	A 63-year-old male with multiple myeloma (IgD-l) received autologous peripheral blood stem cell transplantation (PBSCT) after induction of VAD in March 2008, and obtained a very good partial response.	25745970
Parkinson Disease	Stem Cell Exhaustion	Human induced pluripotent stem cell-derived neurons improve motor asymmetry in a 6-hydroxydopamine-induced rat model of Parkinson's disease.	25747741
palladium, Parkinson Disease	Stem Cell Exhaustion	Since human embryonic stem cells and human fetal neural stem cells have immune rejection and ethical issues, recent advancements in induced pluripotent stem cells (iPS cells) provide new possibilities to study autologous cell therapy for Parkinson's disease (PD).	25747741
palladium	Stem Cell Exhaustion	We isolated human skin fibroblasts from normal individuals and patients with PD; we generated iPS cells by transfecting these human skin fibroblasts with retroviral reprogramming factors of OCT4, SOX2, KLF4 and c-MYC and induced iPS cells to differentiate neural stem cells (NSCs) and then into neurons and dopamine neurons in vitro.	25747741
Clostridium difficile colitis, Peripheral Stem Cell Transplantation, Acute GVH disease, Aspergillosis	Stem Cell Exhaustion	Acute graft-versus-host disease, invasive aspergillosis and Clostridium difficile colitis after peripheral blood stem cell transplantation: A complex network of causalities and a challenge for prevention.	25749258
Graft-vs-Host Disease, Central Diabetes Insipidus	Stem Cell Exhaustion	We report a case of a 58-years-old patient who developed an IA within a protected room, CDI and GVHD after allogeneic allogeneic peripheral blood stem cell transplantation (PBSCT).	25749258
Mycoses	Stem Cell Exhaustion	Safety and efficacy of micafungin for prophylaxis against invasive fungal infections in Japanese patients undergoing hematopoietic stem cell transplantation: Results of a post-marketing surveillance study.	25749360
Mycoses	Stem Cell Exhaustion	Invasive fungal infections are a major cause of morbidity and mortality in patients with hematopoietic stem cell transplantation.	25749360
Mycoses	Stem Cell Exhaustion	A prospective multicenter post-marketing observational surveillance study was conducted from July 2007 to June 2010 to assess the safety and efficacy of micafungin, an echinocandin antifungal, for prophylaxis against invasive fungal infections in Japanese patients undergoing hematopoietic stem cell transplantation.	25749360
Mycoses	Stem Cell Exhaustion	In conclusion, micafungin had sufficient safety and efficacy for prophylaxis against invasive fungal infections in Japanese patients with various backgrounds undergoing hematopoietic stem cell transplantation.	25749360
Anemia	Stem Cell Exhaustion	Haematopoietic progenitor cells show special sensitivity to mitochondrial DNA (mtDNA) mutagenesis, which suggests that increased mtDNA mutagenesis could underlie anemias.	25751021
Abdominal Neoplasms, Neoplasms, epinephrine, niobium	Stem Cell Exhaustion	A 4-year-old, female patient with a high risk adrenal NB was found to have a 2.9-cm, right thyroid nodule on surveillance chest computed tomography (CT) 6 months after completion of her NB treatment (induction chemotherapy, tumor resection, autologous stem cell transplantation, external beam radiation to the abdominal tumor site, immunotherapy, and retinoic acid).	25751324
Multiple Myeloma	Stem Cell Exhaustion	G-CSF plus preemptive plerixafor vs hyperfractionated CY plus G-CSF for autologous stem cell mobilization in multiple myeloma: effectiveness, safety and cost analysis.	25751646
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The optimal stem cell mobilization regimen for patients with multiple myeloma (MM) remains undefined.	25751646
Toxic effect	Stem Cell Exhaustion	The chemo-mobilization approach was associated with twofold stem cell yield, slightly lower cost but significantly increased toxicity.	25751646
Doctor of Chiropractic	Stem Cell Exhaustion	Here we show that epigenetic regulator and central transcriptional instructor in adult stem cells, Bmi1, protects against DCM by repressing cardiac senescence.	25751743
Multiple Myeloma	Stem Cell Exhaustion	The role of positron emission tomography with 18F-fluorodeoxyglucose integrated with computed tomography in the evaluation of patients with multiple myeloma undergoing allogeneic stem cell transplantation.	25754658
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Positron emission tomography (PET) integrated with computed tomography (PET/CT) has been reported to be useful for screening myelomatous lesions at diagnosis in patients with multiple myeloma (MM) and for monitoring response to autologous stem cell transplantation (auto-SCT).	25754658
Hypoxia	Stem Cell Exhaustion	Pre-clinical studies have shown that hypoxia preconditioning can enhance stem cell therapeutic potential for myocardial repair.	25755063
Specialty Type - cancer, Thyroid carcinoma	Stem Cell Exhaustion	Expression of cancer stem cell markers and epithelial-mesenchymal transition-related factors in anaplastic thyroid carcinoma.	25755746
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cell markers such as CD133 and nestin were more highly expressed in ATC than PTC (52.9% versus 5%, 52.9% versus 0%, respectively).	25755746
Specialty Type - cancer	Stem Cell Exhaustion	We used immunohistochemistry to examine the expression of multiple markers of cancer stem cells and EMT-activating transcriptional factors.	25755746
Primary immune deficiency disorder	Stem Cell Exhaustion	Long-lasting production of new T and B cells and T-cell repertoire diversity in patients with primary immunodeficiency who had undergone stem cell transplantation: a single-centre experience.	25756054
Primary immune deficiency disorder	Stem Cell Exhaustion	Levels of Kappa-deleting recombination excision circles (KRECs), T-cell receptor excision circles (TRECs), and T-cell repertoire diversity were evaluated in 1038 samples of 124 children with primary immunodeficiency, of whom 102 (54 with severe combined immunodeficiency and 48 with other types of immunodeficiency) underwent hematopoietic stem cell transplantation.	25756054
Connective Tissue Diseases, Diabetes, Head and neck structure, Hepatitis C, Benign prostatic hypertrophy, Post-Traumatic Stress Disorder	Stem Cell Exhaustion	The following independent risk factors showed significant association with DES: diabetes (odds ratio [OR], 1.408; 95% confidence interval [CI], 1.031 to 1.924), hepatitis C (OR, 3.326; 95% CI, 1.632 to 6.776); connective tissue disease (OR, 2.157; 95% CI, 1.679 to 2.771), benign prostatic hyperplasia (OR, 3.892; 95% CI, 2.476 to 6.116), rosacea (OR, 3.747; 95% CI, 1.972 to 7.120), posttraumatic stress disorder (OR, 1.449; 95% CI, 1.043 to 2.013), hematopoietic stem cell transplantation (OR, 7.269; 95% CI, 2.312 to 22.849), head and neck radiotherapy (OR, 8.776; 95% CI, 3.096 to 24.873), postmenopausal estrogen therapy (OR, 1.912; 95% CI, 1.160 to 3.151), antihistamines (OR, 2.040; 95% CI, 1.516 to 2.746), antidepressants (OR, 1.982; 95% CI, 1.077 to 3.647), contact lenses (OR, 2.366; 95% CI, 1.266 to 4.423), and video display terminal exposure for more than 6 h/d (OR, 2.275; 95% CI, 1.451 to 3.568).	25756335
Malignant neoplasm of stomach	Stem Cell Exhaustion	We report a case of limbal stem cell deficiency that occurred in a patient receiving chemotherapy using S-1 alone for gastric cancer.	25756340
Rotator Cuff Injuries, Tears body substance	Stem Cell Exhaustion	While the use of bone marrow concentrate (BMC) has been described in the treatment of rotator cuff tears, the impact of a rotator cuff injury on the mesenchymal stem cells (MSCs) content present in the human shoulder has not been determined, especially with regard to changes in the levels of MSCs at the tendon-bone interface.	25757411
Hemoglobinuria, Paroxysmal nocturnal hemoglobinuria, Hemolysis (biological function), Thrombosis	Stem Cell Exhaustion	Paroxysmal nocturnal haemoglobinuria (PNH) is a rare acquired haematopoietic stem cell disorder characterised by persistent haemolysis and platelet activation, severe end-organ damage, an increased risk of thrombosis and early mortality.	25757938
Lymphoma, leukemia	Stem Cell Exhaustion	The burden of care and quality of life of caregivers of leukemia and lymphoma patients following peripheric stem cell transplantation.	25758128
Lymphoma, leukemia	Stem Cell Exhaustion	This study was conducted to identify the burden of care and quality of life of caregivers of leukemia and lymphoma patients who had undergone peripheric stem cell transplantation.	25758128
Hematoma, Cerebrovascular accident	Stem Cell Exhaustion	Cervical epidural hematoma in a healthy donor presenting stroke mimic symptoms: a rare adverse event following peripheral blood stem cell apheresis.	25759485
Numbness, Usual Severity Pain	Stem Cell Exhaustion	A female sibling donor, aged 61 years with an unremarkable medical history, complained of pain in the left neck and shoulder and numbness in the left upper limb 1 h after the end of peripheral blood stem cell apheresis.	25759485
Brain Infarction, Hematoma	Stem Cell Exhaustion	This report is the first case of cervical epidural hematoma in a healthy donor who underwent peripheral blood stem cell apheresis and presented symptoms confusingly similar to those of brain infarction.	25759485
Amyotrophic Lateral Sclerosis	Stem Cell Exhaustion	A comprehensive library of familial human amyotrophic lateral sclerosis induced pluripotent stem cells.	25760436
Hematologic Neoplasms	Stem Cell Exhaustion	Safety and efficacy of granulocyte colony-stimulating factor biosimilars in engraftment after autologous stem cell transplantation for haematological malignancies: a 4-year, single institute experience with different conditioning regimens.	25761321
Infantile encephalopathy	Stem Cell Exhaustion	Unrelated donor hematopoietic stem cell transplantation for infantile enteropathy due to IL-10/IL-10 receptor defect.	25761563
NBN wt Allele	Stem Cell Exhaustion	PSY measurement in DBS could serve as a 2nd tier assay in NBS for KD, simplify and reduce the cost of follow up protocols, help determine disease progression, and be used to monitor KD patients following hematopoietic stem cell transplantation.	25762404
Neoplasms	Stem Cell Exhaustion	Both modalities allow accurate localization of disease after chemotherapy or autologous stem cell transplantation and can provide important prognostic information that can influence further clinical decision making regarding therapy, particularly when tumor serum markers may be a less reliable indicator of disease burden after repeated treatments.	25763728
Alzheimers Disease	Stem Cell Exhaustion	Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks.	25765079
Graft-vs-Host Disease	Stem Cell Exhaustion	An effective graft-versus-host disease (GVHD) preventative approach that preserves the graft-versus-tumor effect after allogeneic hematopoietic stem cell transplantation (HSCT) remains elusive.	25765556
Graft-vs-Host Disease, leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The impact of graft-versus-host disease prophylaxis in reduced-intensity conditioning allogeneic stem cell transplant in acute myeloid leukemia: a study from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation.	25769546
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This study addresses this issue in 228 adult patients above 50 years of age with acute myeloid leukemia in first complete remission given peripheral blood stem cells from HLA-identical siblings after fludarabine and 2 days of intravenous busulfan reduced-intensity conditioning.	25769546
End Stage Liver Disease	Stem Cell Exhaustion	We aimed to evaluate clinical therapeutic effects of human umbilical cord-derived mesenchymal stem cell (UCMSC) transplantation in the treatment of end-stage liver diseases.	25769583
End Stage Liver Disease	Stem Cell Exhaustion	Clinical therapeutic effects of human umbilical cord-derived mesenchymal stem cells transplantation in the treatment of end-stage liver disease.	25769583
Infection, Neoplasms	Stem Cell Exhaustion	Early lymphocyte recovery after allogeneic hematopoietic stem cell transplantation (HSCT) is related to the prevention of serious infections and the clearing of residual tumor cells.	25769599
Febrile Neutropenia, Specialty Type - cancer	Stem Cell Exhaustion	Febrile neutropenic infection occurred in cancer patients undergoing autologous peripheral blood stem cell transplantation.	25769601
Fever, Specialty Type - cancer	Stem Cell Exhaustion	The objective of this study was to investigate the incidence, risk factors, and clinical and prognostic characteristics of febrile infection that occurred during the neutropenic period in cancer patients who underwent autologous peripheral blood stem cell transplantation (APBSCT).	25769601
Osteoporosis	Stem Cell Exhaustion	Comprehensive transcriptome analysis of mesenchymal stem cells in elderly patients with osteoporosis.	25771989
Osteoporosis	Stem Cell Exhaustion	To explore the role of aging in the pathogenesis of osteoporosis, several differentially expressed genes (DEGs) and altered biological pathways were identified in mesenchymal stem cells (MSCs) in elderly patients with osteoporosis.	25771989
Hematologic Neoplasms	Stem Cell Exhaustion	In patients with hematologic malignancies, who underwent their first myeloablative allogeneic hematopoietic cell transplantation, PGF was reported in 1278 (5.5%), and there was a marked difference in PGFs using peripheral blood stem cell compared with bone marrow grafts (2.5 vs 7.3%; P<0.001).	25772027
Ischemic cardiomyopathy	Stem Cell Exhaustion	The graft of stem cells to treat ischemic cardiomyopathy is popular in many clinical trials.	25773139
Lupus Erythematosus, Systemic	Stem Cell Exhaustion	Endoplasmic reticulum stress participates in the progress of senescence of bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus.	25773452
Lupus Erythematosus, Encephalitis, St. Louis	Stem Cell Exhaustion	Previous studies suggested that the senescence of bone marrow mesenchymal stem cells (BM-MSCs) played an important role in the pathological process of systemic lupus erythematosus (SLE).	25773452
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation in very high risk CLL or early relapsed disease has become less important than in the past.	25776793
Alopecia	Stem Cell Exhaustion	Clinical use of conditioned media of adipose tissue-derived stem cells in female pattern hair loss: a retrospective case series study.	25777970
Hematologic Neoplasms	Stem Cell Exhaustion	Patients with high-risk hematologic malignancies received myeloablative therapy followed by transplantation with 2 CB units, one of which was treated ex vivo for 30 minutes with the enzyme fucosyltransferase-VI and guanosine diphosphate fucose to enhance the interaction of CD34(+) stem and early progenitor cells with microvessels.	25778529
Rheumatoid Arthritis	Stem Cell Exhaustion	Red cell distribution width is associated with endothelial progenitor cell depletion and vascular-related mediators in rheumatoid arthritis.	25778627
Rheumatoid Arthritis, Inflammation, Cape Verde	Stem Cell Exhaustion	Since inflammation and Endothelial Progenitor Cells (EPCs) imbalance have been reported in RA patients to be related to CV disease, we wondered whether RDW could be linked to endothelial repair failure in RA.	25778627
Bone Diseases	Stem Cell Exhaustion	Understanding the mechanisms by which bone marrow mesenchymal stem cells (BMSCs) differentiate into bone-forming osteoblasts and marrow adipocytes is crucial to develop strategies for the treatment of several bone diseases.	25779338
Fracture	Stem Cell Exhaustion	Increased incidence of fractures in recipients of hematopoietic stem-cell transplantation.	25779562
Non-Malignant	Stem Cell Exhaustion	The number of long-term survivors after hematopoietic stem-cell transplantation (HSCT) for malignant and nonmalignant disorders is increasing, and late effects are gaining importance.	25779562
Cessation of life	Stem Cell Exhaustion	Interestingly, we found that direct adenosine treatment is sufficient to induce embryonic stem cell-derived motor neuron (ESMN) cell death in cultures.	25779930
Refractory Cytopenia of Childhood	Stem Cell Exhaustion	Furthermore, TIM-3 rendered RCC cells with the ability to induce resistance to sunitinib and mTOR inhibitors, the standard regimen for patients with ccRCC, as well as stem cell activities.	25783986
Depression, CTCAE, Anxiety Disorders, Acute Coronary Syndrome	Stem Cell Exhaustion	Influence of depression and anxiety on circulating endothelial progenitor cells in patients with acute coronary syndromes.	25784019
Coronary Arteriosclerosis	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPCs) are related to endothelial function and progression of coronary artery disease.	25784019
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The optimal intensity of conditioning for allogeneic hematopoietic stem cell transplantation (HCT) in acute myeloid leukemia (AML) remains undefined.	25784222
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Outcome of acute myeloid leukemia patients with pulmonary nodules of uncertain etiology receiving allogeneic hematopoietic progenitor cell transplant.	25784319
Infection, Communicable Diseases	Stem Cell Exhaustion	They pose potential challenges to successful hematopoietic progenitor cell (HPC) transplant as they may be niches for infection reactivation or sites susceptible to subsequent infections.	25784319
Multiple Myeloma	Stem Cell Exhaustion	Dose-intensified bendamustine followed by autologous peripheral blood stem cell support in relapsed and refractory multiple myeloma with impaired bone marrow function.	25784529
Toxic effect, Hematopoiesis	Stem Cell Exhaustion	We hypothesized that dose-intensified bendamustine (180 mg/m2 , day 1 and 2) followed by autologous blood stem cell support (ASCS) would improve bone marrow function with low post-transplant toxicity in patients with severely impaired haematopoiesis.	25784529
Primary Myelofibrosis	Stem Cell Exhaustion	Impact of allogeneic stem cell transplantation on survival of patients less than 65 years of age with primary myelofibrosis.	25784679
Primary Myelofibrosis, PMF Regimen	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (SCT) is the only curative option for patients with primary myelofibrosis (PMF), but information on its net advantage over conventional therapies is lacking.	25784679
Specialty Type - cancer, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Cancer stem cells (CSCs, also called cancer stem-like cells, CSLCs) can function as "seed cells" for tumor recurrence and metastasis.	25788271
Liver carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Increased Expression of Circulating Cancer Stem Cell Markers During the Perioperative Period Predicts Early Recurrence After Curative Resection of Hepatocellular Carcinoma.	25791790
Liver carcinoma, Hollings Cancer Center, Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	This study was designed to investigate the correlation between postoperative recurrence of hepatocellular carcinoma (HCC) and perioperative expression and dynamic changes in cancer stem cell (CSC) markers in tumors and peripheral blood.	25791790
Neoplasms, leukemia	Stem Cell Exhaustion	Expression of Robo4 was recently found in solid tumors and leukemia stem cells.	25794001
Neoplasms	Stem Cell Exhaustion	Robo4 is involved in hematopoietic stem/progenitor cell homeostasis and essential for tumor angiogenesis.	25794001
Complication Aspects, Diabetes	Stem Cell Exhaustion	Percutaneous injection of bone marrow mesenchymal stem cells for ankle non-unions decreases complications in patients with diabetes.	25795249
diabetic	Stem Cell Exhaustion	Eighty-six ankle non-union in diabetic patients were treated with bone marrow mesenchymal stem cells (BM-MSCs) delivered in an autologous bone marrow concentrate (BMC).	25795249
Liver Cirrhosis	Stem Cell Exhaustion	REpeated AutoLogous Infusions of STem cells In Cirrhosis (REALISTIC): a multicentre, phase II, open-label, randomised controlled trial of repeated autologous infusions of granulocyte colony-stimulating factor (GCSF) mobilised CD133+ bone marrow stem cells in patients with cirrhosis.	25795699
Hepatobiliary Disorder	Stem Cell Exhaustion	Primary objective is to demonstrate an improvement in the severity of liver disease over 3 months using either G-CSF alone or G-CSF followed by repeated infusions of haematopoietic stem cells compared with standard conservative management.	25795699
Malignant neoplasm of nasopharynx	Stem Cell Exhaustion	Safety and efficacy study of nasopharyngeal cancer stem cell vaccine.	25796196
Malignant neoplasm of nasopharynx	Stem Cell Exhaustion	In this trial, nasopharyngeal cancer stem cells (CSCs) were separated and cultured to produce a vaccine; its safety and efficacy were prospectively evaluated in low-, medium-, and high-dose groups.	25796196
Hodgkin Disease	Stem Cell Exhaustion	Brentuximab vedotin as consolidation therapy after autologous stem-cell transplantation in patients with Hodgkin's lymphoma at risk of relapse or progression (AETHERA): a randomised, double-blind, placebo-controlled, phase 3 trial.	25796459
Hodgkin Disease	Stem Cell Exhaustion	High-dose therapy followed by autologous stem-cell transplantation is standard of care for patients with relapsed or primary refractory Hodgkin's lymphoma.	25796459
Hodgkin Disease	Stem Cell Exhaustion	Patients with unfavourable-risk relapsed or primary refractory classic Hodgkin's lymphoma who had undergone autologous stem-cell transplantation were randomly assigned, by fixed-block randomisation with a computer-generated random number sequence, to receive 16 cycles of 1*8 mg/kg brentuximab vedotin or placebo intravenously every 3 weeks, starting 30-45 days after transplantation.	25796459
Hodgkin Disease	Stem Cell Exhaustion	Early consolidation with brentuximab vedotin after autologous stem-cell transplantation improved progression-free survival in patients with Hodgkin's lymphoma with risk factors for relapse or progression after transplantation.	25796459
Pancreatic Ductal Adenocarcinoma, ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Stem Cell Exhaustion	Stem cell factor (SCF) and hypoxia-inducible factor-1a (HIF-1a) both have important functions in pancreatic ductal adenocarcinoma (PDAC).	25799412
Neutropenia, Kidney Failure, Sepsis, Central Diabetes Insipidus	Stem Cell Exhaustion	Multivariate analysis revealed that age >65 years (OR, 1.13), male gender (OR, 1.14), prolonged LOS, admission to teaching hospital (OR, 1.16), complications of sepsis (OR, 1.83), neutropenia (OR, 1.35), renal failure (OR, 1.18), and bone marrow or stem cell transplantation (OR, 1.27) were significantly associated with CDI occurrence.	25801085
Deficit	Stem Cell Exhaustion	Allogeneic hematopoietic stem-cell transplantation (alloHSCT) survivors treated with total body irradiation (TBI) exhibit bone deficits and excess adiposity, potentially related to altered mesenchymal stem cell differentiation into osteoblasts or adipocytes.	25801428
Autoimmune Diseases	Stem Cell Exhaustion	It is associated with many drugs and diseases including chemotherapy, hematopoietic stem cell transplantation, and autoimmune disorders.	25802198
Graft-vs-Host Disease	Stem Cell Exhaustion	A retrospective chart review included adult allogeneic hematopoietic stem cell patients who received tacrolimus for graft-versus-host disease prophylaxis in 2012.	25802301
Specialty Type - cancer	Stem Cell Exhaustion	Lgr5 expression was not associated with the expression of tested cancer stem cell markers.	25804119
Specialty Type - cancer	Stem Cell Exhaustion	Based on the lack of correlation between Lgr5 and tested cancer stem cell markers, Lgr5 does not seem to be a potential stemness marker or prognostic factor in PDAC.	25804119
Specialty Type - cancer, Pancreatic carcinoma	Stem Cell Exhaustion	Lgr5 expression, cancer stem cells and pancreatic cancer: results from biological and computational analyses.	25804119
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	SD44+/CD24- markers of cancer stem cells in patients with breast cancer of different molecular subtypes.	25804234
Neoplasms, Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	To determine frequency of tumors with immunohistochemical markers of cancer stem cells (CSC) CD44+/CD24- in patients with breast cancer (BC) of different molecular subtype and to evaluate their prognostic value.	25804234
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic stem cell transplant may improve the outcome of adult patients with inv(16) acute myeloid leukemia in first complete remission with poor molecular responses to chemotherapy.	25804769
Anorectal fistula	Stem Cell Exhaustion	To study the results of stem-cell therapy under a Compassionate-use Program for patients with recurrent anal fistulae.	25805941
Anorectal fistula	Stem Cell Exhaustion	Under controlled circumstances, and approved by European and Spanish laws, a Compassionate-use Program allows the use of stem-cell therapy for patients with very complex anal fistulae.	25805941
Anorectal fistula	Stem Cell Exhaustion	Recurrent anal fistulae: limited surgery supported by stem cells.	25805941
Anorectal fistula	Stem Cell Exhaustion	Stem cells are safe and useful for treating anal fistulae.	25805941
Adult Glioblastoma	Stem Cell Exhaustion	Paracrine effects of mesenchymal stem cells induce senescence and differentiation of glioblastoma stem-like cells.	25806680
Neoplasms	Stem Cell Exhaustion	Since mesenchymal stem cells (MSCs) display high tumor tropism, we examined possible antitumor effects of the secreted factors from human MSCs on four GSLC lines (NCH421k, NCH644, NIB26, and NIB50).	25806680
Cytomegalovirus Infections	Stem Cell Exhaustion	Hematopoietic stem cell transplantation from anti-cytomegalovirus immunoglobulin G (anti-CMV-IgG) positive donors facilitated immunological recovery post-transplant, which may indicate that chronic CMV infection has an effect on the immune system.	25807050
Hematologic Neoplasms	Stem Cell Exhaustion	We evaluated the composition of lymphocytes at hematologic recovery in 99 patients with hematologic malignancies post hematopoietic stem cell transplantation (HSCT).	25807050
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Following the recognition that hematopoietic stem cells improve the outcome of myocardial infarction in animal models, bone marrow mononuclear cells, CD34-positive cells, and mesenchymal stromal cells have been introduced clinically.	25807105
Disease	Stem Cell Exhaustion	However, the identification of resident cardiac stem cells in the human heart (hCSCs) has created great expectation concerning the potential implementation of this category of autologous cells for the management of the human disease.	25807105
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Thiotepa-based versus total body irradiation-based myeloablative conditioning prior to allogeneic stem cell transplantation for acute myeloid leukaemia in first complete remission: a retrospective analysis from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation.	25807864
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This retrospective matched-pair analysis evaluated the outcome of adults with acute myeloid leukaemia in first complete remission who received myeloablative conditioning either with a thiotepa-based (n = 121) or a cyclophosphamide/total body irradiation-based (TBI; n = 358) regimen for allogeneic hematopoietic stem cell transplantation from an HLA-matched sibling or an unrelated donor.	25807864
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Specific Preferences in Lineage Choice and Phenotypic Plasticity of Glioma Stem Cells Under BMP4 and Noggin Influence.	25808628
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Although BMP4-induced differentiation of glioma stem cells (GSCs) is well recognized, details of the cellular responses triggered by this morphogen are still poorly defined.	25808628
leukemia	Stem Cell Exhaustion	Haploidentical stem cell transplantation in patients aged 50 yr and older with leukemia: similar outcomes compared to younger adults.	25809115
Tuberculosis, Pulmonary	Stem Cell Exhaustion	Mycobacterium tuberculosis-specific and MHC class I-restricted CD8+ T-cells exhibit a stem cell precursor-like phenotype in patients with active pulmonary tuberculosis.	25809750
Specialty Type - cancer	Stem Cell Exhaustion	All nine niches expressed stromal-derived factor-1a (SDF-1a), its receptor C-X-C chemokine receptor type 4 (CXCR4), osteopontin and cathepsin K. SDF-1a plays a role in homing of CXCR4+ stem cells and leukocytes, whereas osteopontin and cathepsin K promote migration of cancer cells and leukocytes.	25809793
Cytomegalovirus Infections	Stem Cell Exhaustion	CMV antigenemia tests were ordered in 58 patients depending on the clinical context, and the incidence of CMV reactivation and proven/suspected CMV disease requiring antiviral therapy was 20% (24 of 120) and 11% (13 of 120) respectively, including those without stem cell transplantation (SCT).	25810117
Molecular	Stem Cell Exhaustion	To identify molecular defects contributing to metabolic dysregulation in DS in the undifferentiated state, we generated mesenchymal progenitor cells (MPCs) from induced pluripotent stem cells derived from a 4-week-old female with DS and a healthy newborn male (control).	25811318
Hypocalcemia	Stem Cell Exhaustion	Reliance solely on hematopoietic stem cell transplantation can leave hypocalcemia uncorrected with sometimes fatal consequences.	25811986
Extramedullary Plasmacytoma, Multiple Myeloma	Stem Cell Exhaustion	The t(11;14)(q13;q32) translocation as a poor prognostic parameter for autologous stem cell transplantation in myeloma patients with extramedullary plasmacytoma.	25812994
Extramedullary Plasmacytoma, Multiple Myeloma, MAEA gene, Morular Metaplasia of the Endometrium, Chromosome Aberrations	Stem Cell Exhaustion	However, there are few data about the prognostic significance of cytogenetic abnormalities for autologous stem cell transplantation (ASCT) in multiple myeloma (MM) patients with extramedullary plasmacytoma (EMP).	25812994
Specialty Type - cancer, Hollings Cancer Center	Stem Cell Exhaustion	Methylation of 24 genes and expression of 22 cancer stem cell (CSC) biomarkers were quantitatively measured in 10 paired primary and recurrent HCC specimens.	25815780
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Lung fibroblasts share mesenchymal stem cell features which are altered in chronic obstructive pulmonary disease via the overactivation of the Hedgehog signaling pathway.	25815884
Chronic Obstructive Airway Disease, Lung Neoplasms	Stem Cell Exhaustion	We investigated the stem cell features and the expression of Hedgehog components in human lung fibroblasts isolated from histologically-normal parenchymal tissue from 25 patients--8 non-smokers/non-COPD, 8 smokers-non COPD and 9 smokers with COPD--who were undergoing surgery for lung tumor resection.	25815884
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Our study reveals that lung fibroblasts possess mesenchymal stem cell-features which are impaired in COPD via the contribution of an abnormal Hedgehog signaling.	25815884
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	We found that lung fibroblasts resemble mesenchymal stem cells in terms of cell surface marker expression, differentiation ability and immunosuppressive potential and that these properties were altered in lung fibroblasts from smokers and even more in COPD patients.	25815884
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Primary treatment response rather than front line stem cell transplantation is crucial for long term outcome of peripheral T-cell lymphomas.	25815886
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Mortality patterns among recipients of autologous hematopoietic stem cell transplantation for lymphoma and myeloma in the past three decades.	25816932
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Understanding the mortality patterns of patients with lymphoma and myeloma, who have undergone autologous hematopoietic stem cell transplantation (ASCT) might identify improvement opportunities.	25816932
Hemorrhage	Stem Cell Exhaustion	Incidence and risk factors for life-threatening bleeding after allogeneic stem cell transplant.	25817436
Hemorrhage	Stem Cell Exhaustion	Bleeding is a frequent complication after allogeneic haematopoietic stem cell transplantation (HSCT) and may affect survival.	25817436
Pericardial Effusion, CTCAE	Stem Cell Exhaustion	Risk factors for pericardial effusion in adult patients receiving allogeneic haematopoietic stem cell transplantation.	25818840
Pericardial Effusion, CTCAE	Stem Cell Exhaustion	Pericardial effusion (PE) is a rare but potentially life-threatening complication for allogeneic haematopoietic stem cell transplantation (HSCT) recipients.	25818840
Septicemia	Stem Cell Exhaustion	After hematopoietic stem cell transplantation from a full-matched sibling was performed, the patient expired due to graft failure and septicemia.	25818969
Aplastic Anemia	Stem Cell Exhaustion	In aplastic anaemia (AA), haemopoietic activity is significantly reduced and generally attributed to failure of haemopoietic stem cells (HSC) within the bone marrow (BM).	25819548
Aneuploidy	Stem Cell Exhaustion	Here, we analyze the response of primary human cells and murine hematopoietic stem cells (HSCs) to aneuploidy induction and the role of telomeres and the telomerase in this process.	25820263
Specialty Type - cancer	Stem Cell Exhaustion	Thirty-two oral presentations were delivered on various themes, such as therapeutic agents, cancer stem cells, EMT signaling, molecular epidemiology, cellular senescence, and clinical research, to more than 80 participants.	25820597
Degenerative polyarthritis	Stem Cell Exhaustion	Treatment of Knee Osteoarthritis With Allogeneic Bone Marrow Mesenchymal Stem Cells: A Randomized Controlled Trial.	25822648
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Decitabine as a conditioning regimen in haploidentical stem cell transplantation for refractory acute myeloid leukaemia.	25825260
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Chemotherapy can increase treatment-related mortality associated with future haematopoietic stem cell transplantation (HSCT) for patients with relapsed/refractory acute myeloid leukaemia (AML).	25825260
Graft-vs-Host Disease, Cataract	Stem Cell Exhaustion	To study the outcomes of cataract surgery in patients with graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT).	25826324
Pulmonary arterial hypertension, Unknown (origin) (qualifier value)	Stem Cell Exhaustion	Elevated serum levels of macrophage migration inhibitory factor and stem cell growth factor b in patients with idiopathic and systemic sclerosis associated pulmonary arterial hypertension.	25829187
Spinal Cord Injuries	Stem Cell Exhaustion	Stem cell growth factor b (SCGF b) is a human growth factor that, together with MIF, is involved in the pathogenesis of chronic spinal cord injury.	25829187
Infection	Stem Cell Exhaustion	Invasive mold infections (IMI) are among the most devastating complications following chemotherapy and hematopoietic stem cell transplantation (HSCT), with high mortality rates.	25835547
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Aldehyde dehydrogenase 1 (ALDH-1) is a cancer stem cell marker whose overexpression can predict the prognosis of several human cancers.	25837433
Specialty Type - cancer	Stem Cell Exhaustion	This study indicates that the reduction of the cancer stem cell population via chemoradiotherapy may not be sufficient to improve patient survival.	25837433
Malignant tumor of cervix, Neoplasms	Stem Cell Exhaustion	Twenty-nine of the 74 cervical cancer cases exhibited ALDH-1 expression (39.19 %) in the pre-treatment tissue samples; however, only 19 of these 39 cases exhibited ALDH-1 expression (48.72 %) in post-treatment tissue samples, indicating that chemoradiotherapy eliminated the ALDH-1 positive tumor stem cells in cervical cancer.	25837433
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	To clarify the clinical impact of prior use of azacitidine (AZA) on outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for myelodysplastic syndrome (MDS), we retrospectively reviewed the clinical outcomes of 15 MDS patients who were treated with AZA before allo-HSCT (AZA group).	25837848
Neoplasms	Stem Cell Exhaustion	Nestin is a neuroepithelial stem cell marker that is expressed in some types of tumor cells.	25839093
leukemia	Stem Cell Exhaustion	Age and Modified European LeukemiaNet Classification to Predict Transplant Outcomes: An Integrated Approach for Acute Myelogenous Leukemia Patients Undergoing Allogeneic Stem Cell Transplantation.	25840338
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We evaluated the prognostic significance of a modified European LeukemiaNet (ELN) classification for patients with acute myelogenous leukemia (AML) undergoing hematopoietic stem cell transplantation (HSCT) while in first complete remission (CR1).	25840338
Hyperimmunoglobulin M syndrome	Stem Cell Exhaustion	The long-term outcome of X-linked hyper-IgM syndrome (XHIM) caused by mutations in CD40LG is poor, and the only curative treatment is hematopoietic stem cell transplantation (HSCT).	25840720
Primary amyloidosis	Stem Cell Exhaustion	Outcome of Patients with Immunoglobulin Light-Chain Amyloidosis with Lung, Liver, Gastrointestinal, Neurologic, and Soft Tissue Involvement after Autologous Hematopoietic Stem Cell Transplantation.	25842049
Hepatitis B	Stem Cell Exhaustion	Reactivation of hepatitis B virus (HBV) following immunosuppressive therapy or hematopoietic stem cell transplantation is a potentially fatal complication that may occur even in patients with prior resolution of HBV infection.	25842192
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Cytogenetic patterns of relapse following allogeneic stem cell transplantation in morphologic complete remission in patients with acute myeloid leukemia.	25843488
Multiple Myeloma	Stem Cell Exhaustion	High-dose therapy and autologous stem cell transplantation (ASCT) have proven efficacy in patients with multiple myeloma responding well to induction therapy.	25843652
Graft-vs-Host Disease, Failure	Stem Cell Exhaustion	Severe and early onset of aGVHD, bone marrow as the stem cell source, and an HLA mismatch were associated with the failure to respond to GC in logistic regression.	25843653
Specialty Type - cancer	Stem Cell Exhaustion	Aldehyde dehydrogenase 1 (ALDH1), a cancer stem cell marker, has been reported to be altered in human carcinogenesis.	25843691
Acute Coronary Syndrome	Stem Cell Exhaustion	Ticagrelor increases endothelial progenitor cell level compared to clopidogrel in acute coronary syndromes: A prospective randomized study.	25846661
Esophageal	Stem Cell Exhaustion	Recent studies have suggested that oesophageal submucosal gland (ESMG) ducts harbour progenitor cells that may contribute to oesophageal metaplasia.	25847432
Ki-1+ Anaplastic Large Cell Lymphoma, Toxic effect	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is also an effective treatment for relapsed ALCL, although transplant-related toxicity is a problem.	25847601
Richters syndrome", Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Allogeneic stem-cell transplantation (SCT) induces long-term remission in a fraction of patients with high-risk chronic lymphocytic leukemia (CLL) or Richter's transformation (RT).	25847930
Dry Eye Syndromes	Stem Cell Exhaustion	Prospective Randomized Trial Comparing Efficacy of Topical Loteprednol Etabonate 0.5% Versus Cyclosporine-A 0.05% for Treatment of Dry Eye Syndrome Following Hematopoietic Stem Cell Transplantation.	25850708
Dry Eye Syndromes	Stem Cell Exhaustion	To evaluate the safety and efficacy of topical loteprednol etabonate (LE) 0.5% compared with cyclosporine A (CsA) 0.05% for the prophylaxis and treatment of dry eye syndrome (DES) after hematopoietic stem cell transplantation (HSCT).	25850708
Neoplasms	Stem Cell Exhaustion	Hematopoietic progenitor cells collection in pediatric patients with brain tumor.	25851934
Brain Neoplasms	Stem Cell Exhaustion	To analyze the efficacy and safety of hematopoietic progenitor cells (HPC) collections by leukapheresis in pediatric patients with brain tumors.	25851934
Fever	Stem Cell Exhaustion	Long-lasting stem cell-like memory CD8+ T cells with a naive-like profile upon yellow fever vaccination.	25855494
Inflammation, Fibrosis Assessment	Stem Cell Exhaustion	The goal of this study was to test the hypothesis that bone marrow stem cells (CD34+) will improve histological measurements of vascularity, fibrosis, and inflammation in human subjects undergoing left ventricular assist device (LVAD) placement as a bridge to cardiac transplantation.	25857908
Amyloidosis	Stem Cell Exhaustion	Induction Therapy with Bortezomib Followed by Bortezomib-High Dose Melphalan and Stem Cell Transplantation for Light Chain Amyloidosis: Results of a Prospective Clinical Trial.	25858810
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells (CSCs) have been reported to play important roles in multiple cancer types.	25862862
leukemia	Stem Cell Exhaustion	Leukemia cell mobilization with G-CSF plus plerixafor during busulfan-fludarabine conditioning for allogeneic stem cell transplantation.	25867648
Neoplasms	Stem Cell Exhaustion	We hypothesized that during conditioning chemotherapy for allogeneic stem cell transplant (allo-SCT), the disruption of stromal-leukemia interactions using G-CSF in combination with the CXCR4-specific inhibitor, plerixafor, may promote the release of leukemic cells from the niche and increase tumor elimination.	25867648
Leukoencephalopathy, Progressive Multifocal, Leukoencephalopathy	Stem Cell Exhaustion	Extended application of allogeneic stem cell transplantation (alloSCT) is expected to increase the frequency of JC polyomavirus (JCPyV)-related progressive multifocal leukoencephalopathy (PML).	25867649
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation versus novel drugs or conventional chemotherapy for patients with relapsed multiple myeloma after previous ASCT.	25867654
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	High-dose therapy (HDT) followed by autologous stem cell transplantation (ASCT) is the most common first-line treatment for patients with multiple myeloma (MM) under 65 years of age.	25867654
Heart Diseases	Stem Cell Exhaustion	Transplantation of cardiac stem cells (CSCs) may be one of the best strategies to cure adult or pediatric heart diseases.	25867933
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	The NCIC CTG LY.12 study showed that gemcitabine, dexamethasone, and cisplatin (GDP) were noninferior to dexamethasone, cytarabine, and cisplatin (DHAP) in patients with relapsed or refractory aggressive histology lymphoma prior to autologous stem cell transplantation.	25868579
Post-Treatment Lyme Disease Syndrome, Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Posttransplantation lymphoproliferative disorders (PTLDs) are life-threatening complications after solid organ and hematopoietic stem cell transplantation.	25868706
Hemolytic crisis	Stem Cell Exhaustion	Eculizumab dramatically relieved the signs and symptoms and then he safely underwent unrelated bone marrow transplantation, suggesting the feasibility and effectiveness of eculizumab before stem cell transplantation in children with PNH/AA in hemolytic crisis.	25868955
methyldopa	Stem Cell Exhaustion	Pluripotent stem cell-derived retinal pigment epithelial (RPE) cells are currently being tested for cell replacement in late-stage age-related macular degeneration (AMD).	25869002
methyldopa	Stem Cell Exhaustion	Here, we demonstrate that transplantation of neural progenitor cells (NPCs) derived from induced pluripotent stem cells (iNPCs) limits disease progression in the Royal College of Surgeons rat, a preclinical model of AMD.	25869002
Hematologic Neoplasms, Mortality, Premature	Stem Cell Exhaustion	Productivity loss due to premature mortality caused by blood cancer: a study based on patients undergoing stem cell transplantation.	25869153
Hematologic Neoplasms	Stem Cell Exhaustion	Stem cell transplantation has been used for many years to treat haematological malignancies that could not be cured by other treatments.	25869153
Hematologic Neoplasms	Stem Cell Exhaustion	Our purpose was to evaluate labour productivity losses associated with premature mortality due to blood cancer in recipients of stem cell transplantations.	25869153
Hematologic Neoplasms	Stem Cell Exhaustion	We collected primary data from the clinical histories of blood cancer patients who had undergone stem cell transplantation between 2006 and 2011 in two Spanish hospitals.	25869153
Chronic Obstructive Airway Disease, Pulmonary arterial hypertension	Stem Cell Exhaustion	Influence of Rho kinase inhibitor fasudil on late endothelial progenitor cells in peripheral blood of COPD patients with pulmonary artery hypertension.	25869561
Chronic Obstructive Airway Disease, Lung Diseases, Obstructive, Pulmonary arterial hypertension	Stem Cell Exhaustion	To investigate the influence of Fasudil, a Rho inhibitor on the number and functions of the late endothelial progenitor cells in peripheral blood of chronic obstructive pulmonary diseases (COPD) patients with pulmonary artery hypertension.	25869561
Chronic Obstructive Airway Disease, Pulmonary arterial hypertension	Stem Cell Exhaustion	The Rho-kinase inhibitor Fasudil increased the number and enhanced the function of the late endothelial progenitor cells in peripheral blood of COPD patients with pulmonary artery hypertension (Tab.	25869561
Hematologic Neoplasms	Stem Cell Exhaustion	Autologous Stem-Cell Transplantation Without Hematopoietic Support for the Treatment of Hematologic Malignancies in Jehovah's Witnesses.	25870085
Lymphoma, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Autologous stem-cell transplantation (ASCT) has shown to provide curative benefit in patients with relapsed lymphoma and multiple myeloma (MM), often requiring hematopoietic support until marrow engraftment.	25870085
Fungemia, Neoplasms	Stem Cell Exhaustion	Fungemia occurred in 333 (0.23%; 95% confidence interval [CI], .21-.26) patients, ranging from 0.15% in patients with solid tumors to 1.55% in hematopoietic stem cell transplantation recipients.	25870323
Infection	Stem Cell Exhaustion	Life-threatening Streptococcus pneumoniae infections often occur after hematopoietic stem cell transplant (HSCT); vaccination is important for prevention.	25870329
Malignant neoplasm of lung	Stem Cell Exhaustion	IL-8 confers resistance to EGFR inhibitors by inducing stem cell properties in lung cancer.	25871388
Diabetes, Diabetic Foot	Stem Cell Exhaustion	Circulating endothelial progenitor cells and angiogenic factors in diabetes complicated diabetic foot and without foot complications.	25872462
Neoplasms, Hepatitis, Specialty Type - cancer	Stem Cell Exhaustion	Active specific immunotherapy (ASI) with autologous dendritic cells (DC) presenting antigens from autologous tumor stem cell (TC) lines is associated with promising long-term survival in metastatic cancer, but hepatitis patients were excluded.	25873455
Liver carcinoma, Hepatitis, Neoplasms	Stem Cell Exhaustion	Phase I trial of active specific immunotherapy with autologous dendritic cells pulsed with autologous irradiated tumor stem cells in hepatitis B-positive patients with hepatocellular carcinoma.	25873455
Ischemic stroke	Stem Cell Exhaustion	Circulating endothelial progenitor cells and the risk of vascular events after ischemic stroke.	25874380
Electrocardiogram: myocardial infarction (finding), Microalbuminuria, In-Stent Restenosis Indicator	Stem Cell Exhaustion	Association between microalbuminuria predicting in-stent restenosis after myocardial infarction and cellular senescence of endothelial progenitor cells.	25874702
Microalbuminuria, Acute myocardial infarction	Stem Cell Exhaustion	We investigated the role of microalbuminuria to the function of endothelial progenitor cells (EPCs), that might affect to outcome of acute myocardial infarction (AMI) patients.	25874702
Inflammation, Hyperplasia	Stem Cell Exhaustion	This chronic inflammation results in the repression of gut local immune response, which in turn leads to the over-proliferation and mis-differentiation of the intestinal stem cells, thereby resulting in gut hyperplasia.	25875575
HD Term Type	Stem Cell Exhaustion	Importantly, RTP801 protein levels were elevated in both neural telencephalic progenitors differentiated from HD patient-derived induced pluripotent stem cells and in the putamen and cerebellum of human HD postmortem brains.	25876513
Specialty Type - cancer	Stem Cell Exhaustion	It is thought that stem cells have the potential to be induced into a cancer stem cell phenotype and that these may play an important role in resistance to radiotherapy.	25877536
Neoplasms	Stem Cell Exhaustion	Several models of radiation have predicted that stem cells play an important role in tumour initiation and that bystander responses could play a role in proliferation and self-renewal.	25877536
Multiple Myeloma, melphalan/prednisone protocol	Stem Cell Exhaustion	Patients with untreated or relapsed multiple myeloma not eligible for high-dose chemotherapy followed by autologous stem cell transplantation and who were scheduled for bortezomib mono- or combination therapy or melphalan-prednisone (MP) alone were included in this study.	25877940
Polyneuropathy	Stem Cell Exhaustion	Polyneuropathy improvement following autologous stem cell transplantation for POEMS syndrome.	25878176
POEMS Syndrome, Endocrine System Diseases, Neuropathy, Polyneuropathy, Organomegaly	Stem Cell Exhaustion	To study the evolution of the neuropathy and long-term disability in a large cohort of patients with POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) syndrome following autologous stem cell transplantation (ASCT).	25878176
Specialty Type - cancer	Stem Cell Exhaustion	The cancer-associated fibroblast (CAF), one of the most important cellular components in the cancer stroma, might contribute to the progression of the disease due to its plasticity, a behavior of the stem cells.	25879842
Secondary Neoplasm, Hepatocarcinogenesis	Stem Cell Exhaustion	Our data provides evidence of the plasticity of the CAF and the NTF as stem cells in the process of hepatocarcinogenesis and metastasis.	25879842
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Single cell sorting and culture were performed in the various sets of hematopoietic stem cells including CD34+CD38- acute myeloid leukemia (AML) cell population (ASCs) from a total of 60 patients with AML, and 11 healthy controls.	25881148
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	The Leucine rich repeat containing G protein coupled receptor 5 (LGR5), may be a candidate marker of non-small cell lung cancer (NSCLC) cells with stem cell-like properties.	25881507
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	Aldehyde dehydrogenase 1A1 (ALDH1A1) is one of NSCLC stem cell markers.	25881507
Non-Small Cell Lung Carcinoma, Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	The expression of LGR5 and ALDH1A1 were closely associated with the tumorigenicity, metastasis and poor prognosis of NSCLC, and LGR5+ cells in NSCLC were likely to be the cancer cells with stem cell-like properties due to the significant correlation between LGR5 and ALDH1A1.	25881507
Acute leukemia	Stem Cell Exhaustion	Comparison of outcomes after unrelated cord blood and unmanipulated haploidentical stem cell transplantation in adults with acute leukemia.	25882700
Acute leukemia	Stem Cell Exhaustion	Outcomes after unmanipulated haploidentical stem cell transplantation (Haplo) and after unrelated cord blood transplantation (UCBT) are encouraging and have become alternative options to treat patients with high-risk acute leukemia without human leukocyte antigen (HLA) matched donor.	25882700
Heart failure	Stem Cell Exhaustion	Human cardiac progenitor cells (hCPC) improve heart function after autologous transfer in heart failure patients.	25882843
Colorectal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Still, this picture might be more complex since chemotherapy by itself might alter MDR activity, and furthermore, today limited data is available about MDR activity of cancer stem cells in colorectal cancers.	25885226
Spinal Cord Injuries	Stem Cell Exhaustion	Chronic spinal cord injury treated with transplanted autologous bone marrow-derived mesenchymal stem cells tracked by magnetic resonance imaging: a case report.	25885347
Cervical spinal cord structure	Stem Cell Exhaustion	Intrathecal transplantation is a minimally invasive method for the delivery of stem cells, however, whether the cells migrate from the lumbar to the injured cervical spinal cord has not been proved in humans.	25885347
Cervical spinal cord injury	Stem Cell Exhaustion	We describe an attempt to track bone marrow-derived mesenchymal stem cells in a patient with a chronic cervical spinal cord injury.	25885347
Subluxation of atlantoaxial joint, Spinal Cord Injuries	Stem Cell Exhaustion	A 33-year-old Thai man who sustained an incomplete spinal cord injury from the atlanto-axial subluxation was enrolled into a pilot study aiming to track bone marrow-derived mesenchymal stem cells, labeled with superparamagnetic iron oxide nanoparticles, from intrathecal transplantation in chronic cervical spinal cord injury.	25885347
Cervical spinal cord structure	Stem Cell Exhaustion	Intrathecal injection of bone marrow-derived stem cells at the lumbar spine level could deliver the cells to the injured cervical spinal cord.	25885347
Immunocompromised Host	Stem Cell Exhaustion	However, its clinical manifestations are almost exclusively seen in immunocompromised patients, particularly in kidney and hematopoietic stem cell transplantation recipients.	25886491
Acute lymphocytic leukemia	Stem Cell Exhaustion	A 15-y-old female suffering from common B-cell acute lymphoblastic leukaemia underwent hematopoietic stem cell transplantation.	25886491
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Factors influencing life satisfaction in acute myeloid leukemia survivors following allogeneic stem cell transplantation: a cross-sectional study.	25888906
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic stem cell transplantation (alloSCT) is the preferred option of postremission therapy for high-risk patients suffering from acute myeloid leukemia (AML).	25888906
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSCs) are defined with the ability to be self-renewal and potentially promote proliferation and formation of tumors.	25889325
Antilymphocyte Serum	Stem Cell Exhaustion	Human neural stem cell transplantation in ALS: initial results from a phase I trial.	25889343
Cessation of life	Stem Cell Exhaustion	We transplanted GMP-grade, fetal human neural stem cells from natural in utero death (hNSCs) into the anterior horns of the spinal cord to test for the safety of both cells and neurosurgical procedures in these patients.	25889343
Chronic Kidney Diseases	Stem Cell Exhaustion	SIRT1 activation rescues doxorubicin-induced loss of functional competence of human cardiac progenitor cells.	25889431
Heart failure	Stem Cell Exhaustion	To determine whether SIRT1 activator, resveratrol (RES), interferes with adverse effects of DOXO on cardiac progenitor cells (CPCs): 1) human CPCs (hCPCs) were exposed in vitro to DOXO or DOXO+RES and their regenerative potential was tested in vivo in an animal model of DOXO-induced heart failure; 2) the in vivo effects of DOXO+RES co-treatment on CPCs were studied in a rat model.	25889431
Specialty Type - cancer	Stem Cell Exhaustion	Pharmacological intervention at the level of tissue-specific progenitor cells may provide cardiac benefits for the growing population of long-term cancer survivors that are at risk of chemotherapy-induced cardiovascular toxicity.	25889431
Aniridia, Burn injury, Conjunctivitis	Stem Cell Exhaustion	Sixteen eyes of 16 patients who had total (n=14) and partial (n=2) limbal stem cell deficiency (chemical burns, five eyes; iatrogenic causes, four eyes; aniridia, three eyes; trachoma-induced, two eyes; contact lens over-wear, one eye; and cicatrising conjunctivitis, one eye) and who had failed prior therapy were recruited prospectively into the study.	25889475
Multiple Myeloma	Stem Cell Exhaustion	Predicting poor peripheral blood stem cell collection in patients with multiple myeloma receiving pre-transplant induction therapy with novel agents and mobilized with cyclophosphamide plus granulocyte-colony stimulating factor: results from a Gruppo Italiano Malattie EMatologiche dell'Adulto Multiple Myeloma Working Party study.	25889496
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	A still not well defined proportion of patients with multiple myeloma (MM) and eligible for autologous stem cell transplantation (AuSCT) fails to mobilize CD34+ peripheral blood stem cells (PBSC) at all or to collect an adequate number for a safe procedure or sufficient for multiple transplants.	25889496
Liver Failure, Acute	Stem Cell Exhaustion	Compared with human primary fetal liver cells, human hepatic stem cell transplantation rescued Alb-TRECK/SCID mice with lethal fulminant hepatic failure, and human hepatic stem cell-derived humanized livers secreted more human albumin into mouse sera and also functioned as a "human liver" that could metabolize the drugs ketoprofen and debrisoquine.	25889844
protein reconstitution, Liver Failure, Acute	Stem Cell Exhaustion	Human hepatic stem cells transplanted into a fulminant hepatic failure Alb-TRECK/SCID mouse model exhibit liver reconstitution and drug metabolism capabilities.	25889844
Diphtheria Toxin, Liver Failure, Acute	Stem Cell Exhaustion	Both human primary fetal liver cells and hepatic stem cells were successfully repopulated in the livers of Alb-TRECK/SCID mice that developed lethal fulminant hepatic failure after administering diphtheria toxin; the repopulation rate in some mice was nearly 100%.	25889844
B-Cell Lymphomas	Stem Cell Exhaustion	CD34+ selected versus unselected autologous stem cell transplantation in patients with advanced-stage mantle cell and diffuse large B-cell lymphoma.	25890431
Medial collateral ligament, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	High-dose chemotherapy (HDCT) with autologous stem cell transplantation (ASCT) has improved progression-free (PFS) and overall survival (OS) in MCL and relapsed DLBCL.	25890431
Neurotoxicity Syndromes, Multiple Myeloma	Stem Cell Exhaustion	Neurotoxicity of stem cell mobilization chemotherapy with vinorelbine in myeloma patients after bortezomib treatment.	25891070
Polyneuropathy, Multiple Myeloma	Stem Cell Exhaustion	Our data indicate that a single administration of vinorelbine to mobilize autologous stem cells is associated with significant additional polyneuropathy in bortezomib pretreated myeloma patients.	25891070
Specialty Type - cancer, Cholangiocarcinoma	Stem Cell Exhaustion	Profiles of cancer stem cell subpopulations in cholangiocarcinomas.	25892683
Specialty Type - cancer, Congenital contractural arachnodactyly	Stem Cell Exhaustion	We characterized cancer stem cells (CSCs) in CCA subtypes and evaluated their cancerogenic potential.	25892683
Mantle cell lymphoma	Stem Cell Exhaustion	Allogeneic Hematopoietic Stem Cell Transplantation in Mantle Cell Lymphoma: A Retrospective Analysis of 7 Patients.	25895548
Juvenile Myelomonocytic Leukemia	Stem Cell Exhaustion	Notably, unlike most JMML cases, Patient 2 did not require steroids or hematopoietic stem cell transplantation.	25896945
Hepatic Veno-Occlusive Disease, Lymphoma	Stem Cell Exhaustion	High pre-transplant serum ferritin and busulfan-thiotepa conditioning regimen as risk factors for hepatic sinusoidal obstructive syndrome after autologous stem cell transplantation in patients with malignant lymphoma.	25899401
Hepatic Veno-Occlusive Disease, Spondylo-ocular syndrome, Lymphoma	Stem Cell Exhaustion	Few studies have evaluated the risk factors for hepatic sinusoidal obstructive syndrome (SOS) in patients with malignant lymphoma receiving autologous stem cell transplantation (ASCT).	25899401
Nasal Type Extranodal NK/T-Cell Lymphoma	Stem Cell Exhaustion	High-dose therapy and autologous stem cell transplantation for extra-nodal NK/T lymphoma in patients from the Western hemisphere: a study from the European Society for Blood and Marrow Transplantation.	25899403
Primary Myelofibrosis	Stem Cell Exhaustion	Safety and outcome of allogeneic stem cell transplantation in myelofibrosis.	25899468
Lymphoma	Stem Cell Exhaustion	Prognostic factors of lymphoma patients after autologous stem cell transplantation.	25903985
Lymphoma	Stem Cell Exhaustion	BacKGROUND: Hematopoietic stem cell transplantation (HSCT) is considered to be a cure for lymphoma.	25903985
Malignant Head and Neck Neoplasm	Stem Cell Exhaustion	We confirmed the dysregulation of these noncoding RNAs in head and neck cancer cell lines derived from different anatomic sites, and determined that ectopic expression of the two lncRNAs inhibited key EMT and stem cell genes and reduced cellular proliferation and migration.	25904139
Thrombocytosis, Chronic myeloproliferative disorder, Polycythemia Vera, Primary Myelofibrosis	Stem Cell Exhaustion	Chronic myeloproliferative disorders such as polycythemia vera (PV), essential thrombocytosis (ET), and idiopathic myelofibrosis arise from clonal proliferation of neoplastic stem cells in the bone marrow.	25906101
Fungal Colonization, Infection, Communicable Diseases, Hematologic Neoplasms	Stem Cell Exhaustion	Fungal colonization and infections remain a major cause of infection morbidity and mortality following hematopoietic stem cell transplantation (HSCT) in patients with hematological malignancies.	25907308
Trial Disease Assessments Domain	Stem Cell Exhaustion	We studied hemostasis changes using thromboelastography (TEG), thrombin generation test (TGT) and thrombodynamics (TD) in primary MM patients (PMMpt, n=25) and patients in remission (RMMpt, n=34) during blood stem cell (BSC) mobilization.	25907422
Phaeohyphomycosis	Stem Cell Exhaustion	Fifty-six patients with phaeohyphomycosis were identified from 15 centers, comprising 26 stem cell transplant (SCT) and 30 solid organ transplant (SOT) recipients.	25908651
Toxic effect	Stem Cell Exhaustion	In summary, this combination is effective in untreated patients, with an acceptable toxicity profile, but given the introduction of second-generation novel agents and monoclonal antibodies, the combination will probably be better reserved for relapsing patients, in whom stem cell collection is not needed, while cost-effective combinations with non-cross-resistant drugs continue to represent a medical need.	25911554
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Because the indication of allograft (allogeneic stem cell transplantation [alloSCT]) for multiple myeloma (MM) has widened in recent years, thanks to the development of reduced-intensity conditionings (RIC), it is still unclear if myeloablative conditioning (MAC) remains appropriate.	25911579
Complement Membrane Attack Complex	Stem Cell Exhaustion	RIC and MAC populations were different regarding age (53.5 versus 47.1 years, respectively), number of prior autologous (auto)SCTs (93.2% versus 79.6% had at least 2 autoSCTs), and stem cell source (90.2% versus 61.2% received peripheral blood).	25911579
Chronic graft-versus-host disease, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Mild chronic graft-versus-host disease may alleviate poor prognosis associated with FLT3 internal tandem duplication for adult acute myeloid leukemia following allogeneic stem cell transplantation with myeloablative conditioning in first complete remission: a retrospective study.	25912052
FLT3 Internal Tandem Duplication, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The significance of FLT3-ITD at diagnosis was retrospectively estimated for allo-HSCT (allogeneic hematopoietic stem cell transplantation) outcomes in 140 patients, median age of 38, undergoing allo-HSCT after myeloablative conditioning in first complete remission of AML.	25912052
Infection of bloodstream	Stem Cell Exhaustion	The Changing Epidemiology of Bloodstream Infections and Resistance in Hematopoietic Stem Cell Transplantation Recipients.	25912636
Behavioral Symptoms Index Composite Score (BASC-2), Infection of bloodstream	Stem Cell Exhaustion	Patients receiving hematopoietic stem cell transplantation (HSCT) are exposed to highly immunosuppressive conditions and bloodstream infections (BSIs) are one of the most common major complications within this period.	25912636
Atherosclerosis	Stem Cell Exhaustion	Effects of olmesartan on endothelial progenitor cell mobilization and function in carotid atherosclerosis.	25913171
Atherosclerosis	Stem Cell Exhaustion	Our study aimed to explore the effects and mechanism of olmesartan on endothelial progenitor cell mobilization and function in carotid atherosclerosis.	25913171
Atherosclerosis	Stem Cell Exhaustion	However, its role in the function of endothelial progenitor cells in atherosclerosis patients is still unclear.	25913171
Carotid Atherosclerosis	Stem Cell Exhaustion	Olmesartan can effectively promote the endothelial progenitor cells mobilization and improve their function in patients with carotid atherosclerosis, independent of basic characteristics.	25913171
Neuromyelitis Optica	Stem Cell Exhaustion	Resolution of aquaporin-4 antibodies in a woman with neuromyelitis optica treated with human autologous stem cell transplant.	25913278
N-nitrosomorpholine, Neuromyelitis Optica	Stem Cell Exhaustion	We report a 47-year-old woman with highly active neuromyelitis optica (NMO) and persistent high titre anti-aquaporin-4 antibodies (anti-AQP-4) who was resistant to multiple immune therapies until she underwent autologous hematopoietic stem cell transplant (auto-HSCT).	25913278
Osteogenesis	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) isolated from spinal ligaments with ectopic ossification have a propensity toward the osteogenic lineage.	25913759
Autoimmune Diseases, Lupus Erythematosus, Encephalitis, St. Louis	Stem Cell Exhaustion	Autologous hematopoietic stem cell (HSC) and mesenchymal stem cell (MSC) transplantation is currently being evaluated as a novel treatment for autoimmune diseases, such as systemic lupus erythematosus (SLE).	25914407
Lupus Erythematosus, Lupus Nephritis, White blood cell count decreased	Stem Cell Exhaustion	Combined transplantation of autologous hematopoietic stem cells and allogenic mesenchymal stem cells increases T regulatory cells in systemic lupus erythematosus with refractory lupus nephritis and leukopenia.	25914407
leukemia	Stem Cell Exhaustion	Conventional strategies are not particularly successful in the treatment of leukaemia, and identification of signalling pathways crucial to the activity of leukaemia stem cells will provide targets for the development of new therapies.	25915125
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The LAIR1-SHP-1-CAMK1-CREB pathway sustains the survival and self-renewal of AML stem cells.	25915125
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	In a variety of tumors, cancer cells with stem cell-like properties seem to form the basis of tumor initiation because of their ability to self-renew and proliferate.	25916394
Malignant Neoplasms	Stem Cell Exhaustion	Further studies are required to validate whether some stem cell-associated markers, such as SOX2, could serve as targets for therapeutic approaches and whether NGFR expression could be utilized as a predictor of malignancy.	25916394
Retinal Pigments	Stem Cell Exhaustion	Comparative study between amniotic-fluid mesenchymal stem cells and retinal pigmented epithelium (RPE) stem cells ability to differentiate towards RPE cells.	25916690
Blastic plasmacytoid dendritic cell neoplasm	Stem Cell Exhaustion	Long-term survival following autologous and allogeneic stem cell transplantation for blastic plasmacytoid dendritic cell neoplasm.	25918345
Blastic plasmacytoid dendritic cell neoplasm	Stem Cell Exhaustion	We sought to clarify the role of high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (auto-HSCT) and allogeneic hematopoietic stem cell transplantation (allo-HSCT) to treat blastic plasmacytoid dendritic cell neoplasm (BPDCN).	25918345
Rheumatoid Arthritis	Stem Cell Exhaustion	Mesenchymal stem cells from patients with rheumatoid arthritis display impaired function in inhibiting Th17 cells.	25918734
Immune System Diseases	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) possess multipotent and immunomodulatory properties and are suggested to be involved in the pathogenesis of immune-related diseases.	25918734
Pituitary Neoplasms, Neoplasms	Stem Cell Exhaustion	Pituitary tumors contain a side population with tumor stem cell-associated characteristics.	25921430
Adenoma	Stem Cell Exhaustion	The human adenoma pSP also showed upregulated expression of the pituitary stem cell marker SOX2.	25921430
Pituitary Neoplasms, Neoplasms	Stem Cell Exhaustion	In the present study, we searched for a side population (SP) in pituitary tumors representing cells with high efflux capacity and potentially enriched for tumor stem cells (TSCs).	25921430
Peripheral Arterial Diseases	Stem Cell Exhaustion	Therapeutic Efficacy of Stem Cell-based Therapy in Peripheral Arterial Disease: A Meta-Analysis.	25923119
Ulcer	Stem Cell Exhaustion	After synthesizing data, the meta-analysis showed significant improvement in the amputation rate (OR=0.33, 95%CI=0.22-0.51; P<0.001), ulcer healing (OR=6.11, 95%CI=3.04-12.28; P<0.001), and ABI (SMD=0.65, 95%CI=0.33-0.97; P<0.001) for the stem cell-based therapy group compared with the controls.	25923119
Ulcer	Stem Cell Exhaustion	Moreover, significant improvement in the amputation rate, ulcer healing, and ABI were also found based on the time point and stem cell source.	25923119
altretamine/cisplatin/cyclophosphamide protocol	Stem Cell Exhaustion	Long-term, regular RIPre improved endothelial function in patients with CHD, possibly due to STAT-3 activation, and this may have led to an increase in endothelial progenitor cells.	25923462
Scleroderma	Stem Cell Exhaustion	Successful autologous hematopoietic stem cell transplantation for a patient with rapidly progressive localized scleroderma.	25923607
Scleroderma	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplant (HSCT) for rapidly progressive disease has not been reported in localized scleroderma.	25923607
Infection	Stem Cell Exhaustion	Six patients were recipients of allogeneic hematopoietic stem cell transplant, with their infections caused by five Legionella species.	25926494
Specialty Type - cancer	Stem Cell Exhaustion	Epithelial-mesenchymal transition (EMT) is involved in important malignant features of cancer cells, like invasion, metastatic potential, anti-apoptotic and stem-cell like phenotypes.	25928859
Hematologic Neoplasms	Stem Cell Exhaustion	Most patients had underlying hematologic malignancies (54 %), and 7 % were recipients of hematopoietic stem cell transplantation.	25929421
Enterovirus Gastroenteritis	Stem Cell Exhaustion	Characteristics and outcomes of patients diagnosed with norovirus gastroenteritis after allogeneic hematopoietic stem cell transplantation based on immunochromatography.	25930664
Enterovirus Gastroenteritis	Stem Cell Exhaustion	Norovirus gastroenteritis (NV-GE) is a highly transmittable disease that can lead to fatal outcomes in vulnerable populations including patients after hematopoietic stem cell transplantation (HSCT).	25930664
Werner Syndrome	Stem Cell Exhaustion	A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.	25931448
ELN wt Allele	Stem Cell Exhaustion	Here, we report on the generation of a human WS model in human embryonic stem cells (ESCs).	25931448
Injury of gastrointestinal tract	Stem Cell Exhaustion	HGF Gene Modification in Mesenchymal Stem Cells Reduces Radiation-Induced Intestinal Injury by Modulating Immunity.	25933295
Amyotrophic Lateral Sclerosis, Antilymphocyte Serum	Stem Cell Exhaustion	Stem cell therapy is an emerging alternative therapeutic or disease-modifying strategy for amyotrophic lateral sclerosis (ALS).	25934946
Age related macular degeneration, Macular degeneration	Stem Cell Exhaustion	Here, we report the safety and tolerability of subretinal transplantation of human embryonic-stem-cell (hESC)-derived retinal pigment epithelium in four Asian patients: two with dry age-related macular degeneration and two with Stargardt macular dystrophy.	25937371
Lymphoma	Stem Cell Exhaustion	BV before high-dose chemotherapy-ASCT did not adversely affect peripheral blood stem cell mobilization and subsequent engraftment in a cohort of heavily pretreated patients with CD30(+) lymphomas.	25937397
Lymphoma	Stem Cell Exhaustion	Hematopoietic Progenitor Cell Harvesting Is Feasible after Treatment with Brentuximab Vedotin in CD30(+) Lymphoma Patients Who Received Multiple Prior Lines of Treatment.	25937397
leukemia	Stem Cell Exhaustion	Health-Related Quality of Life in leukemia Survivors of Allogeneic Hematopoietic Stem Cell Transplantation Employing the Mexican Reduced-Intensity Conditioning.	25938844
Cytomegalovirus Infections	Stem Cell Exhaustion	High graft CD3 stem cell dose was associated with a trend of lower rate of subsequent CMV infection (HR = 0.543, P = 0.056).	25940504
Lupus Vulgaris	Stem Cell Exhaustion	Transplantation of Adipose Tissue-Derived Mesenchymal Stem Cells Prevents the Development of Lupus Dermatitis.	25941899
Periodontal Route of Administration	Stem Cell Exhaustion	Recent animal studies have demonstrated histologically that bone marrow- derived mesenchymal stem cells (MSCs) may enhance the regeneration of periodontal defects in dogs by differentiating MSCs into cementoblasts, osteoblasts and periodontal fibroblasts.	25942341
Gain	Stem Cell Exhaustion	Stem cells in combination with bioresorbable PLA/PGA membrane was effective for root coverage resulted in a significant reduction in gingival recession, greater gain in CAL and WKG.	25942341
diabetic	Stem Cell Exhaustion	Circulating Progenitor Cell Count Predicts Microvascular Outcomes in Type 2 Diabetic Patients.	25942480
Diabetes	Stem Cell Exhaustion	Diabetes reduces the levels of circulating progenitor cells (CPCs) and endothelial progenitor cells (EPCs), which promote vascular repair and are inversely correlated with cardiovascular risk.	25942480
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Levels of circulating (endothelial) progenitor cells predict microvascular outcomes in T2D.	25942480
PAFAH1B1 wt Allele	Stem Cell Exhaustion	To assess its effectiveness, we compared overall survival (OS) between azacitidine and conventional treatment (CCT) in high-risk MDS patients, excluding those undergoing stem cell transplantation, submitted to the Spanish MDS registry from 2000 to 2013.	25943181
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	AML patients undergoing IC without stem-cell transplant at two tertiary care centers were enrolled in a prospective, longitudinal study.	25944029
Virus Reactivation	Stem Cell Exhaustion	Large-scale multiplex polymerase chain reaction assay for diagnosis of viral reactivations after allogeneic hematopoietic stem cell transplantation.	25946433
Virus Reactivation	Stem Cell Exhaustion	Viral reactivations following hematopoietic stem cell transplantation are thought to result from the breakdown of both cell-mediated and humoral immunity.	25946433
Virus Reactivation	Stem Cell Exhaustion	Multiplex PCR was useful for detecting many viral reactivations after hematopoietic stem cell transplantation, simultaneously.	25946433
Dry Eye Syndromes, Stable chronic Graft vs Host Disease, Specialty Type - cancer, Chronic graft-versus-host disease, Graft-vs-Host Disease	Stem Cell Exhaustion	To investigate the factors associated with the development of ocular graft-versus-host disease (oGVHD) dry eye syndrome (DES) in patients with chronic GVHD (cGVHD) after receiving allogenic haematopoietic stem cell transplantation (AHSCT) METHODS: A retrospective chart review of patients receiving AHSCT between 1998 and 2013 at the Bone Marrow Transplant Unit of the British Columbia Cancer Agency was carried out.	25947556
methyldopa	Stem Cell Exhaustion	In this work, a tissue-on-a-chip approach was developed through combining human induced pluripotent stem cells, Electric Cell-substrate Impedance Sensing (ECIS) and reproducible electrical wounding assays to model and quantitatively study AMD.	25950942
Leukemia, Myelocytic, Acute, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Our data thus suggest that, in the present case, the AML and DLBCL arose from a common progenitor cell, as indicated by the clonal abnormality t(3,4)(p25;q21), and that different immunoglobulin heavy chain gene rearrangements occurred during each course of clonal evolution.	25953309
Specialty Type - cancer	Stem Cell Exhaustion	Cancer Stem Cells Sensitivity Assay (STELLA) in Patients with Advanced Lung and Colorectal Cancer: A Feasibility Study.	25955492
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells represent a population of immature tumor cells found in most solid tumors.	25955492
Specialty Type - cancer	Stem Cell Exhaustion	In this study, we investigated whether cancer stem cells isolation and in vitro sensitivity assay are feasible in a clinical setting.	25955492
Failure, Specialty Type - cancer, effusion	Stem Cell Exhaustion	Cancer stem cells were isolated from effusions or fresh cancer tissue of 23 patients who progressed after standard therapy failure.	25955492
Secondary malignant neoplasm of liver, Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells were extracted from liver metastases in 6 cases (25%), lung nodules in 2 (8%), lymph node metastases in 3 (12.5%) and pleural/peritoneal/pericardial effusion in 13 (54%).	25955492
Malignant neoplasm of lung, Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells were successfully isolated in 15 patients (63%), including 14 with lung cancer (93.3%).	25955492
Specialty Type - cancer	Stem Cell Exhaustion	The approach used for the STELLA trial allowed isolation of cancer stem cells in a consistent proportion of patients.	25955492
Carotid Artery Injuries	Stem Cell Exhaustion	Transplantation of cryopreserved human umbilical cord blood-derived endothelial progenitor cells induces recovery of carotid artery injury in nude rats.	25956351
Endothelial dysfunction	Stem Cell Exhaustion	Transplantation of endothelial progenitor cells (EPCs) restores endothelial function in patients with endothelial dysfunction and initial denudation.	25956351
Have Been Vomiting, Nausea	Stem Cell Exhaustion	Fosaprepitant for the prevention of nausea and vomiting in patients receiving BEAM or high-dose melphalan before autologous hematopoietic stem cell transplant.	25956421
Nausea, Vomiting	Stem Cell Exhaustion	To assess the impact of single-dose fosaprepitant on nausea and emesis after BEAM and high-dose melphalan conditioning regimens for autologous hematopoietic stem cell transplantation.	25956421
Richters syndrome", Prolymphocytic Leukemia	Stem Cell Exhaustion	The median age was 57 years and median follow-up 36 months; 17 patients had del 17p/p53mutation, 19 patients had fludarabine-refractory disease, 11 relapsed after autologous stem cell transplantation, 8 had diagnosis of prolymphocytic leukemia, 4 had Richter syndrome, and 8 underwent transplantation with progressive or refractory disease.	25958294
Arterial Stiffness	Stem Cell Exhaustion	Secondary outcomes were aerobic capacity, arterial stiffness, numbers of endothelial (EPCs) and osteogenic progenitor cells (OPCs), migratory function of circulatory angiogenic cells, and health-related quality of life.	25960303
Multiple Myeloma	Stem Cell Exhaustion	High-dose therapy and autologous stem cell transplant in older adults with multiple myeloma.	25961765
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Randomized trials showing that high-dose therapy with autologous stem cell transplant (ASCT) improved the overall survival (OS) in multiple myeloma (MM) excluded patients over age 65.	25961765
Job Syndrome, Autosome	Stem Cell Exhaustion	Successful haploidentical donor hematopoietic stem cell transplant and restoration of STAT3 function in an adolescent with autosomal dominant hyper-IgE syndrome.	25962528
Multiple Myeloma	Stem Cell Exhaustion	We retrospectively analyzed our transplant database from July 2000 to June 2012 to identify myeloma patients who received autologous stem cell transplantation while dialysis-dependent.	25963284
Adult Glioblastoma	Stem Cell Exhaustion	mRNA expression levels of hypoxia-induced and stem cell-associated genes in human glioblastoma.	25963717
Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	The roles of hypoxia-induced and stem cell-associated genes in the development of malignancy and tumour progression are well known.	25963717
Adult Glioblastoma, Neoplasms	Stem Cell Exhaustion	However, there are a limited number of studies analysing the impact of mRNA expression levels of hypoxia-induced and stem cell-associated genes in the tissues of brain tumours and glioblastoma patients.	25963717
Neoplasms, Glioblastoma	Stem Cell Exhaustion	Our data revealed higher mRNA expression levels of hypoxia-induced and stem cell-associated genes in tumour tissue than levels in the tumour adjacent tissues in patients with glioblastoma multiforme.	25963717
Tumor Hypoxia	Stem Cell Exhaustion	Additionally, the results indicate the role of stem-cell-related genes in tumour hypoxia.	25963717
Decreased platelet count	Stem Cell Exhaustion	Identification of anti-thrombopoietin receptor antibody in prolonged thrombocytopenia after allogeneic hematopoietic stem cell transplantation treated successfully with eltrombopag.	25964100
Lymphoma, Follicular	Stem Cell Exhaustion	A 55-year-old female with stage IVA follicular lymphoma in third complete remission underwent allogeneic peripheral blood stem cell transplantation.	25964100
Decreased platelet count	Stem Cell Exhaustion	Anti-TPOR antibody may play an important role in some cases of prolonged thrombocytopenia after allogeneic hematopoietic stem cell transplantation with unknown etiology, and eltrombopag could be a novel therapeutic option for such cases.	25964100
leukemia	Stem Cell Exhaustion	The combination of APO866 with Pgp inhibitors resulted in a synergistic cytotoxic effect in leukemia cells, while sparing normal CD34(+) progenitor cells and peripheral blood mononuclear cells.	25964294
Specialty Type - cancer	Stem Cell Exhaustion	Cancer cells are typically defined as infinitely proliferating, whereas normal cells (except stem cells) are considered as being programmed to become senescent.	25964555
Heart Failure, Systolic	Stem Cell Exhaustion	Clinical observation of umbilical cord mesenchymal stem cell treatment of severe systolic heart failure.	25966065
Chronic systolic heart failure	Stem Cell Exhaustion	The aim of this study was to evaluate the effectiveness of umbilical cord mesenchymal stem cells (MSCs) in the treatment of chronic systolic heart failure.	25966065
Specialty Type - cancer	Stem Cell Exhaustion	Relationships between parenting self-efficacy and distress in parents who have school-aged children and have been treated with hematopoietic stem cell transplant or have no cancer history.	25967755
Specialty Type - cancer	Stem Cell Exhaustion	This study sought to address this issue by comparing parents with cancer who had undergone hematopoietic stem cell transplantation (HSCT) to parents without cancer on measures of PSE and psychological distress.	25967755
Toxoplasmosis	Stem Cell Exhaustion	Atovaquone for Prophylaxis of Toxoplasmosis after Allogeneic Hematopoietic Stem Cell Transplantation.	25968483
Infection, Toxoplasmosis, Pneumocystis jiroveci	Stem Cell Exhaustion	Toxoplasmosis and infections by other opportunistic agents such as Pneumocystis jirovecii constitute life-threatening risks for patients after allogeneic hematopoietic stem cell transplantation.	25968483
Toxic effect	Stem Cell Exhaustion	We explored atovaquone as an alternative and compared it with TMP-SMX regarding toxicity and efficacy during the first 100 days after transplantation in 155 consecutive adult stem cell recipients.	25968483
Liver Cirrhosis	Stem Cell Exhaustion	Recently, stem cell transplantation has emerged as a promising treatment for cirrhosis.	25970080
Liver Cirrhosis, Hepatitis	Stem Cell Exhaustion	The aim of this study was to determine whether autologous peripheral blood stem cell transplantation can improve liver functional reserve in patients with hepatitis B-induced cirrhosis.	25970080
Specialty Type - cancer	Stem Cell Exhaustion	Cancer gene aberrations were identified in all specimens and pathway-level analysis was applied to aggregate data, which identified stem cell pluripotency pathway enrichment and highlighted recurring, significant amplification of SOX2, PIK3CA, NTRK1, GNAS, CTNNB1, and FGFR1.	25970776
Multiple Myeloma	Stem Cell Exhaustion	We retrospectively analyzed, and herein discuss, the outcomes of and prognostic factors for 35 untreated multiple myeloma patients less than 65 years of age who received induction therapies with bortezomib (Bor) and dexamethasone (BD) for the purpose of up-front autologous peripheral blood stem cell transplantation (SCT).	25971269
Intestinal Polyposis	Stem Cell Exhaustion	[Multiple myeloma recurring as small intestinal polyposis after autologous hematopoietic stem cell transplantation].	25971270
Bone marrow hypocellularity, Thrombosis, Anemia, Hemolytic, Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal hematopoietic stem cell disorder that presents with hemolytic anemia, thrombosis, and bone marrow failure.	25971274
Multiple Myeloma	Stem Cell Exhaustion	[Successful treatment with pseudo-autologous blood stem cell transplantation for an adolescent-onset multiple myeloma who relapsed after allogenic bone marrow transplantation].	25971275
Graft-vs-Host Disease	Stem Cell Exhaustion	Peripheral blood stem cells (PBSC) were collected and pseudo-autologous PBSC transplantation (PASCT) was performed following high-dose melphalan without graft-versus-host disease prophylaxis.	25971275
Behavior, "Huntingtons Disease Pathway	Stem Cell Exhaustion	Reductions in behavioral deficits and neuropathology in the R6/2 mouse model of Huntington's disease following transplantation of bone-marrow-derived mesenchymal stem cells is dependent on passage number.	25971780
HD Term Type	Stem Cell Exhaustion	Although an effective treatment for HD has remained elusive, current studies using transplants of bone-marrow-derived mesenchymal stem cells provides considerable promise.	25971780
Amyloidosis	Stem Cell Exhaustion	We designed a prospective, multicentre phase II trial of lenalidomide, dexamethasone and cyclophosphamide for newly diagnosed patients with AL amyloidosis not eligible for autologous stem-cell transplantation.	25974382
Amyloidosis	Stem Cell Exhaustion	Our results support the efficacy of this regimen, with high quality responses and prolonged survival, as well as its tolerability, in patients with AL amyloidosis not eligible for stem cell transplant and without advanced cardiac involvement (clinicaltrials.gov identifier: NCT01194791).	25974382
Pancytopenia, Hematological Disease, Aplastic Anemia	Stem Cell Exhaustion	Aplastic anemia is a rare hematopoietic stem-cell disorder that results in pancytopenia and hypocellular bone marrow.	25975012
Autoimmune reaction, Lupus Vulgaris	Stem Cell Exhaustion	Infusion of Human Bone Marrow-Derived Mesenchymal Stem Cells Alleviates Autoimmune Nephritis in a Lupus Model by Suppressing Follicular Helper T-Cell Development.	25975931
Encephalitis, St. Louis	Stem Cell Exhaustion	In recent studies, mesenchymal stem cells (MSCs) elicited diverse, even opposing, effects in experimental and clinical SLE.	25975931
Multiple Myeloma	Stem Cell Exhaustion	Stem cell mobilization and autologous stem cell transplantation after pretreatment with bendamustine, prednisone and bortezomib (BPV) in newly diagnosed multiple myeloma.	25976868
Toxic effect	Stem Cell Exhaustion	Reliable information on stem cell toxicity and mobilization of stem cells for autologous stem cell transplantation (SCT) after induction treatment with a combination of bendamustine, prednisone and bortezomib (BPV) is missing.	25976868
Subcutaneous panniculitis-like T-cell lymphoma	Stem Cell Exhaustion	Hematopoietic stem cell transplantation for primary cutaneous gd T-cell lymphoma and refractory subcutaneous panniculitis-like T-cell lymphoma.	25981001
Stage I Mycosis Fungoides AJCC v7	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HSCT) has been shown to be a potentially curative strategy in aggressive TCLs and in refractory and advanced-stage mycosis fungoides.	25981001
Graft-vs-Host Disease, Aspergillus fumigatus	Stem Cell Exhaustion	We describe an immunosuppressed, 48-year-old male, allogeneic hematopoietic stem cell transplant recipient with severe graft-versus-host disease who developed invasive pulmonary Aspergillus fumigatus infection 6 months after transplant.	25986028
Neoplasms	Stem Cell Exhaustion	For disseminated tumor cells (DTCs) in the BM, tumor cell dormancy, stem cell-like features and discordant receptor status of DTCs as compared to the primary tumor have been described, explaining the failure of conventional therapies.	25986892
Myeloproliferative disease, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myeloid leukemia (CML) is a myeloproliferative disorder of pluripotent stem cells, caused by reciprocal translocation between the long arms of chromosomes 9 and 22, t(9;22)(q34;q11), known as the Philadelphia chromosome.	25987039
Knee joint	Stem Cell Exhaustion	Since the synovial membrane is abundant with mesenchymal progenitor cells (MPCs) capable of differentiating into cartilage both in vitro and in vivo, we examined if p21 expression levels varied between MPCs derived from normal vs. OA knee joints.	25987237
Degenerative polyarthritis	Stem Cell Exhaustion	The results of this study suggest that cell cycle regulation in MPCs may be altered in OA and that modulation of this pathway may have therapeutic potential once the mechanism by which this regulates stem/progenitor cells is better understood.	25987237
Clostridium difficile colitis	Stem Cell Exhaustion	Contribution of Clostridium difficile infection to the development of lower gastrointestinal adverse events during autologous stem cell transplantation.	25988273
gastrointestinal	Stem Cell Exhaustion	Lower gastrointestinal (GI) adverse events (LGAE) are common afflictions of patients undergoing stem cell transplantation (SCT).	25988273
Septic Shock	Stem Cell Exhaustion	Donor Nucleotide-Binding Oligomerization-Containing Protein 2 (NOD2) Single Nucleotide Polymorphism 13 Is Associated with Septic Shock after Allogeneic Stem Cell Transplantation.	25988661
Septic Shock	Stem Cell Exhaustion	In this study, we analyzed 38 patients with septic shock after allogeneic stem cell transplantation (allo-SCT) for an association of SNPs within NOD2 and TLR5 genes, with susceptibility to septic shock.	25988661
Lupus Erythematosus	Stem Cell Exhaustion	Leptin and Neutrophil-Activating Peptide 2 Promote Mesenchymal Stem Cell Senescence Through Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway in Patients With Systemic Lupus Erythematosus.	25989537
Lupus Erythematosus, Systemic, Encephalitis, St. Louis	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) derived from patients with systemic lupus erythematosus (SLE) exhibit enhanced senescence.	25989537
Lymphoproliferative Disorders	Stem Cell Exhaustion	Is there a difference in post-transplant lymphoproliferative disorder in adults after solid organ and haematologic stem cell transplantation?	25989696
Post-transplant lymphoproliferative disorder, Lymphoproliferative Disorders	Stem Cell Exhaustion	To determine if there is a difference in post-transplant lymphoproliferative disorder (PTLD) in adults after solid organ transplantation (SOT) and haematologic stem cell transplantation (HST).	25989696
Sarcopenia	Stem Cell Exhaustion	Reduced insulin sensitivity in childhood survivors of haematopoietic stem cell transplantation is associated with lipodystropic and sarcopenic phenotypes.	25989749
Acute lymphocytic leukemia, BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 20, BCR gene	Stem Cell Exhaustion	Survivors of childhood acute lymphoblastic leukaemia (ALL) treated with haematopoietic stem cell transplantation and total body irradiation (HSCT/TBI) have a high cardiometabolic risk despite lacking overt clinical obesity.	25989749
Heart failure	Stem Cell Exhaustion	Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report.	25990469
Degenerative polyarthritis	Stem Cell Exhaustion	Mesenchymal stem cell therapy for knee osteoarthritis: 5 years follow-up of three patients.	25990685
herpesvirus 3, human, Simplexvirus	Stem Cell Exhaustion	Low-dose acyclovir prophylaxis for the prevention of herpes simplex virus and varicella zoster virus diseases after autologous hematopoietic stem cell transplantation.	25990803
varicella zoster, herpesvirus 3, human, Simplexvirus	Stem Cell Exhaustion	Limited data are available on prophylaxis for herpes simplex virus (HSV) and varicella zoster virus (VZV) disease following autologous hematopoietic stem cell transplantation (auto-HCT).	25990803
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Next, we analyzed 62 follow-up samples from 6 AML patients after therapy and allogeneic stem cell transplantation (alloSCT).	25994761
leukemia	Stem Cell Exhaustion	It remains to be clarified whether these results simply reflect an accumulation of favorable molecular phenotypes in the AML-ma subgroup or whether they rely on biological differences such as a higher proportion of leukemia stem cells and/or a higher degree of genetic instability within the AML-im subgroup.	25994787
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A flow cytometric maturity score was developed in order to distinguish "mature" AML (AML-ma) from "immature" AML (AML-im) by quantitative expression levels of early progenitor cell antigens (CD34, CD117, and TdT).	25994787
Malignant neoplasm of skin	Stem Cell Exhaustion	Our data indicate for the first time that Numb is involved in the maintenance of the undifferentiated proliferating stem cell pool in the epithelial basal layer and its expression could become a new marker in skin cancer.	25994834
Ancell-Spiegler cylindromas, Neoplasms	Stem Cell Exhaustion	The occurrence of analogous tumors, dermal cylindromas, and membranous basal cell adenoma of the parotid gland, in the same patient may result from the action of a single gene on ontogenetically similar stem cells.	25995191
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Several studies have demonstrated the effect of autologous hematopoietic stem cell transplantation (auto-HSCT) as a salvage treatment for patients with relapsed diffuse large B-cell lymphoma (DLBCL).	25995667
Granular Dystrophy, Corneal	Stem Cell Exhaustion	Simultaneous transplantation of limbal stem cells may reduce recurrences of granular dystrophy after corneal transplantation: 2 long-term case reports.	25997048
diabetic	Stem Cell Exhaustion	MicroRNA-130a Targets MAP3K12 to Modulate Diabetic Endothelial Progenitor Cell Function.	25999017
diabetic	Stem Cell Exhaustion	The aim of the present study was to explore the influence of microRNA (miR)-130a dysregulation on the JNK signal pathway through its target MAP3K12 in diabetic endothelial progenitor cells (EPCs).	25999017
Brain Neoplasms	Stem Cell Exhaustion	Future studies are needed to evaluate the benefits of MCP-C for particularly burdened groups of caregivers, such as caregivers of patients with brain tumors and those undergoing hematopoietic stem cell transplantations, and to identify target points of delivery that will optimize the intervention's benefits.	26000705
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Reduced-Intensity Conditioning Combined with (188)Rhenium Radioimmunotherapy before Allogeneic Hematopoietic Stem Cell Transplantation in Elderly Patients with Acute Myeloid Leukemia: The Role of In Vivo T Cell Depletion.	26001695
Neuropathy	Stem Cell Exhaustion	Treatment choice should take into account specific goals of therapy, necessity for rapid disease control, risk of treatment-related neuropathy, immunosuppression and secondary malignancies, and planning for future autologous stem cell transplantation.	26002963
Liver Cirrhosis	Stem Cell Exhaustion	Efficacy of autologous mesenchymal stem cell transplantation in patients with liver cirrhosis.	26006200
Hepatitis C	Stem Cell Exhaustion	In patients with non-responder hepatitis C, HCV RNA levels both became negative after mesenchymal stem cell transplantation.	26006200
Liver diseases	Stem Cell Exhaustion	Many study results encourage the use of autologous bone marrow-derived mesenchymal stem cells for liver diseases.	26006200
Childhood Breast Carcinoma	Stem Cell Exhaustion	Monocytes and macrophages, implications for breast cancer migration and stem cell-like activity and treatment.	26008983
Childhood Breast Carcinoma	Stem Cell Exhaustion	Direct treatment of breast cancer cells in homotypic culture was unable to reduce migration or mammosphere formation.Macrophages promote "pro-tumourigenic" cellular characteristics of breast cancer cell migration and stem cell activity.	26008983
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Influence of donor age in allogeneic stem cell transplant outcome in acute myeloid leukemia and myelodisplastic syndrome.	26009156
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	The impact of donor age in patients with acute myeloid leukemia and myelodysplastic syndrome who underwent allogeneic hematopoietic stem cell transplant (HSCT) remains unclear.	26009156
Lymphoma	Stem Cell Exhaustion	Phase II Trial of Tandem High-Dose Chemotherapy with Autologous Stem Cell Transplantation Followed by Reduced-Intensity Allogeneic Stem Cell Transplantation for Patients with High-Risk Lymphoma.	26009261
Lymphoma	Stem Cell Exhaustion	Many patients with lymphoma relapse after autologous stem cell transplantation (AutoSCT).	26009261
Graft-vs-Host Disease	Stem Cell Exhaustion	Ultrasonographic evaluation of gastrointestinal graft-versus-host disease after hematopoietic stem cell transplantation.	26009803
Graft-vs-Host Disease	Stem Cell Exhaustion	Gastrointestinal graft-versus-host disease (GI-GVHD) is a major and life-threatening complication of hematopoietic stem cell transplantation (HSCT).	26009803
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukemia with monosomal karyotype (MK AML) carries a very poor prognosis, even after allogeneic stem cell transplantation (SCT).	26010466
Liver carcinoma, Hollings Cancer Center	Stem Cell Exhaustion	We aimed to assess the clinicopathological relevance and prognostic significance of expression of the hepatic progenitor cell markers keratin 19 (K19), epithelial cell adhesion molecule (EpCAM) and CD117 (c-KIT) in a White series of hepatocellular carcinoma (HCC).	26011233
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We describe a 33-year-old man with relapsed acute myelogenous leukemia who developed subcutaneous nodules >6 months after allogeneic hematopoietic stem cell transplant.	26012493
Rett Syndrome	Stem Cell Exhaustion	Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage.	26012557
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Control of relapsed or refractory acute myeloid leukemia by clofarabine in preparation for allogeneic stem cell transplant.	26014275
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic stem cell transplant is indicated for patients with refractory or relapsed acute myeloid leukemia (AML).	26014275
Heart Diseases	Stem Cell Exhaustion	Stem cell therapy shows promise for regeneration in heart disease, yet interpatient variability challenges implementation into practice.	26014833
Heart failure, Congestive heart failure	Stem Cell Exhaustion	A reduction in number and function of endothelial progenitor cells (EPCs) occurs in both physiologic aging and chronic heart failure (CHF).	26015451
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Autologous stem cell transplantation is commonly used to treat non-Hodgkin's lymphomas (NHLs).	26018461
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Delta-like 1 homologue (Drosophila) (DLK1) is expressed in malignancies and promotes cancer cell stemness and tumourigenicity, which makes this molecule a potential target for therapies directed against cancer stem/progenitor cells.	26018510
Specialty Type - cancer	Stem Cell Exhaustion	Combination Treatment with All-Trans Retinoic Acid Prevents Cisplatin-Induced Enrichment of CD133+ Tumor-Initiating Cells and Reveals Heterogeneity of Cancer Stem Cell Compartment in Lung Cancer.	26020124
Malignant neoplasm of lung, Specialty Type - cancer, CDISC SDTM Lesion Complexity Terminology	Stem Cell Exhaustion	In addition, our approach discloses a further level of complexity of chemotherapy-resistant CD133+ TICs, revealing phenotypical and functional heterogeneity of the cancer stem cell compartment in lung cancer.	26020124
Glioma, Adult Glioblastoma, Specialty Type - cancer	Stem Cell Exhaustion	Despite few observations, the role of V-ATPase in human tumorigenesis remains unclear.We investigated the expression of ATP6V0C, ATP6V0A2, encoding two subunits belonging to the V-ATPase V0 sector and ATP6V1C, ATP6V1G1, ATPT6V1G2, ATP6V1G3, which are part of the V1 sector, in series of adult gliomas and in cancer stem cell-enriched neurospheres isolated from glioblastoma (GBM) patients.	26020805
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	We revisited the prognostic value of frequently detected somatic gene copy number alterations (CNAs) in mantle cell lymphoma (MCL) patients treated first line with immunochemotherapy and autologous stem cell transplantation (ASCT), with or without high-dose cytarabine, in the randomized European MCL Younger trial.	26022239
Heart Diseases	Stem Cell Exhaustion	To investigate whether Tb4 is important in human cardiac disease and has a role in mediating the beneficial cardiac effects of bone-marrow-derived stem cell (BMSC) therapy, we measured serial plasma Tb4 levels in patients enrolled on the REGENERATE-IHD cell therapy trial.	26022762
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Hematopoietic stem cell transplant (HSCT) is the preferred treatment for young patients with multiple myeloma (MM), but for older adults there is limited evidence on its effectiveness from clinical trials.	26023094
cell injury	Stem Cell Exhaustion	Local injection of mesenchymal stem cells protects testicular torsion-induced germ cell injury.	26025454
Infertility	Stem Cell Exhaustion	The effects of mesenchymal stem cells (MSCs) on acute tissue injury have been demonstrated, and the abilities of paracrine support, differentiation and immune-modulation may benefit to testicular torsion-induced infertility.	26025454
MYELODYSPLASTIC SYNDROME, Impaired T cell function	Stem Cell Exhaustion	Endothelial progenitor cell dysfunction in myelodysplastic syndromes: possible contribution of a defective vascular niche to myelodysplasia.	26025663
Cytomegalovirus Infections	Stem Cell Exhaustion	Role of cytomegalovirus (CMV)-specific polyfunctional CD8+ T-cells and antibodies neutralizing virus epithelial infection in the control of CMV infection in an allogeneic stem-cell transplantation setting.	26025872
Leukemia, Myelocytic, Acute, Multiple Myeloma	Stem Cell Exhaustion	AML transformation after autologous stem cell transplant for multiple myeloma.	26025976
Colorectal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Correlation of HIWI and HILI Expression with Cancer Stem Cell Markers in Colorectal Cancer.	26026091
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSCs) constitute a sub-population of tumor cells that possess stem cell properties, such as self-renewal and the ability of differentiation.	26026091
Colorectal Carcinoma, Specialty Type - cancer, Cytogenetic Complete Response	Stem Cell Exhaustion	The aim of the study was to evaluate the clinical significance of the HIWI and HILI expression and its relationship with cancer stem cells markers in 72 patients with colorectal carcinoma (CRC).	26026091
Specialty Type - cancer	Stem Cell Exhaustion	The expression level of HIWI and HILI and cancer stem cells markers in paired cancerous and non-cancerous tissues was measured by real-time reverse transcription-polymerase chain reaction (RT-PCR) assay.	26026091
Osteoporotic Fractures	Stem Cell Exhaustion	A set of these and of other miRNAs known to change in the context of osteoporotic fractures were subsequently tested for their effects on osteogenic differentiation of human mesenchymal stem cells (MSCs) in vitro.	26026730
Myeloproliferative disease, Primary Myelofibrosis, PMF Regimen	Stem Cell Exhaustion	Primary myelofibrosis (PMF) is a rare myeloproliferative stem cell disorder.	26027540
Hematologic Neoplasms	Stem Cell Exhaustion	Allogeneic stem cell transplantation (ASCT) is a complex medical procedure for some patients with hematologic malignancies.	26028503
Leukemia, Myelocytic, Acute, Complement Membrane Attack Complex	Stem Cell Exhaustion	In recipients of allogeneic hematopoietic stem cell transplantation with AML in CR1, reduced intensity (RIC) conditioning regimens are usually given to older patients and myeloablative regimens (MAC) to younger patients.	26030052
Hepatitis B	Stem Cell Exhaustion	Hepatitis B virus (HBV) reactivation (so-called reverse seroconversion) is a rare but known complication of hematopoietic stem cell transplantation, immunosuppressive therapy, or high-dose chemotherapy plus rituximab.	26031455
Bronchiolitis Obliterans	Stem Cell Exhaustion	Effect of extracorporeal photopheresis on lung function decline for severe bronchiolitis obliterans syndrome following allogeneic stem cell transplantation.	26031713
Posterior reversible encephalopathy syndrome	Stem Cell Exhaustion	There were 55% who received chemotherapy or targeted therapy within the month preceding PRES, including 6 patients who received bevacizumab; PRES followed allogeneic stem cell transplantation in 5 (16%).	26032137
Neoplasms	Stem Cell Exhaustion	Of the patients 29 had solid tumors and 5 underwent hematopoietic stem cell transplantation for benign disease.	26032139
Spinal Cord Injuries	Stem Cell Exhaustion	To examine how trusted communication between individuals with spinal cord injury (ISCIs) and physicians who care for ISCIs is affected by the discussion of advances in stem cell research and interventions locally and abroad.	26032752
Spinal Cord Injuries	Stem Cell Exhaustion	Perspectives on strategies and challenges in the conversation about stem cells for spinal cord injury.	26032752
Stanford Cancer Institute, Spinal Cord Injuries	Stem Cell Exhaustion	A convergence of factors involving transparency impact trusted communication between ISCIs and physicians about stem cells and spinal cord injury (SCI).	26032752
Stanford Cancer Institute	Stem Cell Exhaustion	(2) A new generation of innovations in research and clinical trial dissemination about stem cells for SCI is needed to remedy the perceived inadequacies of existing information content and accessibility.	26032752
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	In the past decade, the number of autologous hematopoietic stem cell transplants (Auto HSCT) for older patients with multiple myeloma (MM) has increased dramatically, as has the cost of transplantation.	26033281
Liver diseases	Stem Cell Exhaustion	Upregulation of osteopontin (OPN) has been found in hepatic progenitor cells (HPCs) in several liver diseases with portal biliary proliferation.	26033745
Liver	Stem Cell Exhaustion	Epithelial cell adhesion molecule EpCAM(+) CD45(-) cells isolated from mouse liver and liver epithelial progenitor cells were used for in vitro study.	26033745
Ischemic, Peripheral Ischemia	Stem Cell Exhaustion	In a murine model of peripheral ischemia, systemic gene therapy with longevity-associated variant-BPIFB4 promotes the recruitment of hematopoietic stem cells, reparative vascularization, and reperfusion of the ischemic muscle.	26034043
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Prognostic Value of FDG PET/CT before Allogeneic and Autologous Stem Cell Transplantation for Aggressive Lymphoma.	26035588
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	To determine the prognostic value of performing fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) before allogeneic and autologous stem cell transplantation (SCT) in patients with aggressive lymphoma.	26035588
Sarcoidosis, Pulmonary	Stem Cell Exhaustion	CD34+ progenitor cells in pulmonary sarcoidosis.	26039017
Sarcoidosis, Pulmonary	Stem Cell Exhaustion	It has been shown that number of CD34+ progenitor cells in peripheral blood was significantly higher in patients with newly diagnosed pulmonary sarcoidosis and showed a positive correlation with CD4/ CD8 rate.	26039017
Sarcoidosis	Stem Cell Exhaustion	CD34+ progenitor cells may be important in the pathogenesis of sarcoidosis.	26039017
Acute leukemia	Stem Cell Exhaustion	Clinical trials have shown that a strategy for haploidentical transplantation based on the infusion of high numbers of T-cell-depleted hematopoietic progenitor cells and no post-transplant immunosuppression controls graft rejection and GvHD in patients with acute leukemia.	26039200
Failure, Acute leukemia	Stem Cell Exhaustion	Relapse is still the major cause of failure of allogeneic stem cell transplantation in high-risk acute leukemia patients.	26039211
varicella zoster	Stem Cell Exhaustion	A Japanese single-hospital observational trial with a retrospective case-control analysis of varicella zoster virus reactivation after autologous peripheral blood stem cell transplantation.	26041667
varicella zoster, herpesvirus 3, human	Stem Cell Exhaustion	Varicella zoster virus (VZV) reactivation following hematopoietic stem cell transplantation (SCT) is common.	26041667
Squamous cell carcinoma, Trauma Symptom Checklist for Children Questionnaire	Stem Cell Exhaustion	In the present study, the expression of BMI1, which controls self-renewal in stem cells, as well as that of ZEB1, a transcription factor that regulates EMT, was evaluated for its role in EMT and the carcinogenic processes of tongue squamous cell carcinoma (TSCC).	26043676
Specialty Type - cancer	Stem Cell Exhaustion	Differential Expression of Cancer Stem Cell Markers ALDH1 and CD133 in Various Lung Cancer Subtypes.	26046383
Malignant neoplasm of lung	Stem Cell Exhaustion	Clinicopathological significance of stem cell markers CD133 and ALDH1 in a large group of lung cancer patients was evaluated.	26046383
Malignant neoplasm of lung, Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells (CSCs) are hypothesized to be the main culprit of lung cancer progression.	26046383
Crohn Disease	Stem Cell Exhaustion	Long-Term Follow-Up of Crohn Disease Fistulas After Local Injections of Bone Marrow-Derived Mesenchymal Stem Cells.	26046409
Chronic heart failure, Congestive heart failure	Stem Cell Exhaustion	To assess content of various subpopulations of endothelial progenitor cells (EPC) with CD45-CD34+, CD14+CD309+ and CD14+CD309+Tie2+ phenotypes in patients with chronic heart failure (CHF) of ischemic origin with preserved left ventricular ejection fraction.	26050484
Herpes Simplex Infections	Stem Cell Exhaustion	Thirteen patients with limbal stem cell deficiency after unilateral (9 eyes) or bilateral (2 eyes) chemical burn, liquid nitrogen injury (1 eye), or herpes simplex virus infection (1 eye).	26050542
Hematologic Neoplasms	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HSCT) is one of curative treatment options for patients with hematologic malignancies.	26052909
Central neuroblastoma, South Ndebele language	Stem Cell Exhaustion	The aim of the study was to evaluate arterial morphology and function in a national cohort of long-term survivors of high-risk neuroblastoma (NBL) treated with high-dose chemotherapy and autologous hematopoietic stem cell transplantation with or without total body irradiation (TBI).	26052933
Multiple Myeloma	Stem Cell Exhaustion	We conducted a retrospective analysis of 102 patients with myeloma who were ineligible for haematopoietic stem cell transplantation between October 2000 and December 2012.	26053837
Osteolysis, Adipose Tissue Atrophy	Stem Cell Exhaustion	(3) Are these two abnormalities (bone osteolysis and fatty atrophy) associated with a decrease of mesenchymal stem cells (MSCs) in bone and in muscle?	26054482
leukemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Maintenance Therapy with Decitabine after Allogeneic Stem Cell Transplantation for Acute Myelogenous Leukemia and Myelodysplastic Syndrome.	26055299
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Current treatments for acute myeloid leukemia (AML) are designed to target rapidly dividing blast populations with limited success in eradicating the functionally distinct leukemia stem cell (LSC) population, which is postulated to be responsible for disease resistance and relapse.	26055302
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Targeting leukemia stem cells in vivo with antagomiR-126 nanoparticles in acute myeloid leukemia.	26055302
lymphoblast	Stem Cell Exhaustion	Despite the dismal outcome, acute lymphoblastic leukemia-type therapy (with central nervous system prophylaxis) and/or allogeneic stem cell transplantation appeared to be the only effective therapies.	26056082
Hematologic Neoplasms	Stem Cell Exhaustion	To characterize the impact of graft T-cell composition on outcomes of reduced-intensity conditioned (RIC) allogeneic hematopoietic stem-cell transplantation (alloHSCT) in adults with hematologic malignancies.	26056179
Specialty Type - cancer	Stem Cell Exhaustion	We begin by reanalysing a recently published dataset to separate the effects of stem cell number and replication rate, and show that each has an independent effect on cancer risk.	26056357
Specialty Type - cancer	Stem Cell Exhaustion	When considering the lifetime number of stem cell divisions in an extended dataset, and removing cases associated with other diseases or carcinogens, we find that lifetime cancer risk per tissue saturates at approximately 0.3-1.3% for the types considered.	26056357
Specialty Type - cancer	Stem Cell Exhaustion	Our results indicate that cancer risk depends not only on the number of stem cell divisions but varies enormously (approx.	26056357
Colorectal Carcinoma	Stem Cell Exhaustion	Analysis of previously published models of colorectal cancer suggests that a two- to three-fold decrease in the mutation rate or stem cell division rate is enough to reduce a whale's cancer risk to that of a human.	26056366
Thrombosis	Stem Cell Exhaustion	Conservative Management of Downhill Esophageal Varices Secondary to Central Line-related Thrombosis After Hematopoietic Stem Cell Transplant.	26056785
Chest Pain, Fever, Coughing	Stem Cell Exhaustion	A 47-year-old stem cell transplant recipient with fever, cough and chest pain.	26057372
Infection, Malignant Neoplasms	Stem Cell Exhaustion	Infections and malignancies are among the most serious complications that follow organ or stem cell transplantation.	26057372
Lung diseases	Stem Cell Exhaustion	The present article describes a case of symptomatic nodular pulmonary disease that complicated hematopoietic stem cell transplantation.	26057372
Neoplasms	Stem Cell Exhaustion	The association between GPC-3 and SALL-4 is a novel finding and suggests that GPC-3 targeting may specifically attack the tumour stem-cell compartment.	26057582
Degenerative polyarthritis	Stem Cell Exhaustion	This study aims to investigate the safety of treatment with autologous bone marrow (BM)-derived mesenchymal stem cells (MSCs) transplanted in patients with OA of the knee, ankle, or hip.	26058927
Respiratory Syncytial Virus Infections	Stem Cell Exhaustion	Adult patients with respiratory syncytial virus infection: impact of solid organ and hematopoietic stem cell transplantation on outcomes.	26059180
Osteoporosis	Stem Cell Exhaustion	SWI/SNF-Mediated Lineage Determination in Mesenchymal Stem Cells Confers Resistance to Osteoporosis.	26059320
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	ABCG2 overexpression in patients with acute myeloid leukemia: Impact on stem cell transplantation outcome.	26059733
Gastrointestinal Stromal Tumors, Neoplasms, Gastrointestinal tract structure	Stem Cell Exhaustion	Gastrointestinal mesenchymal tumours are a group of tumours originating from the mesenchymal stem cells of the gastrointestinal (GI) tract.	26060170
Pterygium	Stem Cell Exhaustion	It is not clear whether demographic or pterygium characteristics or limbal stem cell deficiency determine pterygium recurrence after surgery.	26060460
Pterygium	Stem Cell Exhaustion	To determine whether the demographic, pterygium characteristics, or limbal stem cell deficiency determine pterygium recurrence after excision.	26060460
Anemia, Chronic disease	Stem Cell Exhaustion	Anemia of chronic disease (ACD) is thought to impair the responsiveness of erythroid progenitor cells, but research has shown treatment with recombinant human erythropoietin (rhuEPO) can improve patient hemoglobin levels and, subsequently, overall patient health status and quality of life.	26061404
Fibrosis Assessment, Erectile dysfunction	Stem Cell Exhaustion	Intratunical Injection of Genetically Modified Adipose Tissue-Derived Stem Cells with Human Interferon a-2b for Treatment of Erectile Dysfunction in a Rat Model of Tunica Albugineal Fibrosis.	26062100
Fibrosis Assessment, IGFBP7 protein, human	Stem Cell Exhaustion	To investigate the efficacy of intratunical injection of genetically modified rat adipose tissue-derived stem cells (ADSCs) expressing human interferon a-2b (ADSCs-IFN) in decreasing fibrosis and restoring erectile function in a rat model of tunica albugineal fibrosis (TAF).	26062100
Specialty Type - cancer	Stem Cell Exhaustion	The effectiveness of caregiver social support is associated with cancer survivors' memories of stem cell transplantation: A linguistic analysis of survivor narratives.	26062657
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disorder characterized by dysplastic changes in the bone marrow, ineffective erythropoiesis, and an increased risk of developing acute myeloid leukemia.	26063191
Retinal Diseases	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) are currently being investigated as a treatment for several such retinal diseases based on their neuroprotective and angiogenic potentials.	26065854
Colorectal Carcinoma, Specialty Type - cancer, Secondary malignant neoplasm of liver, Carcinomatosis	Stem Cell Exhaustion	Cancer Stem Cell Markers Are Associated With Distant Hematogenous Liver Metastases But Not With Peritoneal Carcinomatosis in Colorectal Cancer.	26068177
Secondary malignant neoplasm of liver, Specialty Type - cancer, Cytogenetic Complete Response	Stem Cell Exhaustion	To analyze the expression of cancer stem cell markers immunohistochemistry for CD133, CD44 and b-catenin was applied to CRC with exclusive PC, exclusive hepatic metastasis and CRC with combined spread.	26068177
Specialty Type - cancer	Stem Cell Exhaustion	Expression of cancer stem cell markers correlated with hematogeneous metastases to the liver and was absent in patients with exclusive PC.	26068177
Specialty Type - cancer, Cytogenetic Complete Response	Stem Cell Exhaustion	Thus, expression of cancer stem cell markers correlates with different patterns of metastatic spread in CRC.	26068177
Cytogenetic Complete Response	Stem Cell Exhaustion	These data indicate that CRC with exclusive PC lack stem cell features needed for distant dissemination.	26068177
Neoplasms	Stem Cell Exhaustion	We first aimed to generate transformed cell lines from a human induced pluripotent stem cell (hiPSC)-teratoma, and then examined the tumorigenic risks of the differentiated cells from hiPSC explant, because hiPSC-derivatives give rise to tumors in immune-deficient mice when transplanted.	26069211
Coronavirus Infections, Hematologic Neoplasms	Stem Cell Exhaustion	The clinical impact of coronavirus infection in patients with hematologic malignancies and hematopoietic stem cell transplant recipients.	26071326
Hematologic Neoplasms, Communicable Diseases	Stem Cell Exhaustion	Compared to other respiratory viruses, relatively little is known about the clinical impact of coronavirus (CoV) infection after hematopoietic stem cell transplant (HSCT) or in patients with hematologic malignancies.	26071326
Lymphoma	Stem Cell Exhaustion	Vorinostat Combined with High-Dose Gemcitabine, Busulfan, and Melphalan with Autologous Stem Cell Transplantation in Patients with Refractory Lymphomas.	26071868
TRPV6 wt Allele, T-cell leukemia-lymphoma gene	Stem Cell Exhaustion	Despite the remarkable advances in chemotherapy and allogeneic hematopoietic stem cell transplantation (HSCT), adult T-cell leukemia-lymphoma (ATL) is still associated with a high mortality rate.	26073237
diabetic	Stem Cell Exhaustion	Rivaroxaban promoted vessel formation in diabetic mice and improved endothelial progenitor cell function under hyperglycemic conditions.	26077117
Malignant neoplasm of stomach	Stem Cell Exhaustion	Expression of CD47 and CD44, a known gastric cancer stem cell marker, were investigated in gastric cancer cell lines by flow cytometry.	26077800
Traumatic AND/OR non-traumatic injury	Stem Cell Exhaustion	A 4-year-old boy developed unilateral, total limbal stem cell deficiency (LSCD) following an acid injury.	26082100
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Outcome of allogeneic hematopoietic stem-cell transplantation for adult patients with AML and 11q23/MLL rearrangement (MLL-r AML).	26082270
Acute Myeloid Leukemia with Myelodysplasia-Related Changes, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplant overcomes poor prognosis of acute myeloid leukemia with myelodysplasia-related changes.	26084204
Specialty Type - cancer, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	The cancer stem cell (CSC) hypothesis suggests that a subset of cancer cells possesses stem cell properties and is crucial in tumor initiation, metastasis, and drug resistance.	26086949
Childhood Breast Carcinoma	Stem Cell Exhaustion	To determine the mechanism of CSCs in breast cancer, we focused on LGR5, a marker of adult stem cells that potentially serves as a functional factor in CSCs.	26086949
Gastrointestinal mucositis	Stem Cell Exhaustion	Quality of life related to oral mucositis of patients undergoing haematopoietic stem cell transplantation and receiving specialised oral care with low-level laser therapy: a prospective observational study.	26087364
Gastrointestinal mucositis	Stem Cell Exhaustion	Oral mucositis is a painful condition that occurs in 80% of patients who undergo haematopoietic stem cell transplantation (HSCT).	26087364
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Areca nut contributes to oral malignancy through facilitating the conversion of cancer stem cells.	26087469
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	In conclusion, our findings suggested that areca nut contributes to oral malignancy through facilitating the conversion of cancer stem cells.	26087469
Malignant Neoplasms	Stem Cell Exhaustion	[Effectiveness of high-dose polychemotherapy with autologous hemopoietic stem cell transplantation in the treatment for malignant tumors of the central nervous system in children and young adults].	26087603
Malignant neoplasm of brain	Stem Cell Exhaustion	A total of 40 patients (median age 6 years, range 1-28 years) with high-risk malignant brain tumors received a single (n = 35) or tandem (n = 5) high-dose chemotherapy (HDCT) with autologous hemopoietic stem cell transplantation (auto-HSCT).	26087603
Adrenoleukodystrophy	Stem Cell Exhaustion	Transplantation of haploidentical stem cells combined with the infusion of umbilical cord blood is a novel approach for treating cerebral X-linked adrenoleukodystrophy.	26088837
Graft-vs-Host Disease	Stem Cell Exhaustion	When clinically feasible, immune suppression tapering alone in patients who relapse early after reduced intensity conditioning allogeneic stem cell transplantation can produce durable remissions, but is almost always associated with graft-versus-host disease.	26088931
Chronic graft-versus-host disease	Stem Cell Exhaustion	Ocular chronic graft-versus-host disease is one of the most bothersome common complications following allogeneic hematopoietic stem cell transplantation.	26088932
Chronic graft-versus-host disease	Stem Cell Exhaustion	These results support the use of selected transplant clinician- and patient-reported outcome measures for ocular chronic graft-versus-host disease screening when providing care to allogeneic hematopoietic stem cell transplantation survivors with moderate to severe chronic graft-versus-host disease.	26088932
Kidney Diseases	Stem Cell Exhaustion	Circulating Endothelial Progenitor Cell Levels Predict Cardiovascular Events in End-Stage Renal Disease Patients on Maintenance Hemodialysis.	26089157
Toxic effect	Stem Cell Exhaustion	Increased toxicity in older patients limits the delivery of standard consolidation therapies, such as allogeneic stem cell transplant or high-dose cytarabine.	26089240
Graft-vs-Host Disease	Stem Cell Exhaustion	T-cell-depleted (TCD) allogeneic hematopoietic stem cell transplantation demonstrates similar efficacy and reduced incidence and severity of graft-versus-host disease (GVHD) in appropriately selected patients versus T-cell-replete transplantation.	26091510
Graft-vs-Host Disease	Stem Cell Exhaustion	The histopathology of cutaneous acute GVHD (aGVHD) after TCD peripheral blood stem cell transplants (PBSCTs) is not described.	26091510
Colonic Neoplasms	Stem Cell Exhaustion	Human colon CSCs have increased mitochondrial function compared with colon tumor cells without stem cell properties.	26091938
Specialty Type - cancer, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Reagents designed to target cancer stem cells (CSCs) could reduce tumor growth, recurrence, and metastasis.	26091938
Colorectal Carcinoma, Specialty Type - cancer, Secondary Neoplasm, Secondary malignant neoplasm of liver	Stem Cell Exhaustion	Expression of cancer stem cell markers in metastatic colorectal cancer correlates with liver metastasis, but not with metastasis to the central nervous system.	26092596
Colorectal Carcinoma, Neoplasms, Cytogenetic Complete Response	Stem Cell Exhaustion	In colorectal cancer (CRC), metastatic spread is supposed to be mainly driven by tumor cells with stem cell features.	26092596
Specialty Type - cancer	Stem Cell Exhaustion	The present study intended to analyze the correlation between the expression of cancer stem cell markers and patterns of liver or CNS metastases.	26092596
Specialty Type - cancer	Stem Cell Exhaustion	Combination of cancer stem cell markers revealed high discriminatory power for the prediction of different patterns of distant spread.	26092596
Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	This study demonstrates that deregulation of Wnt/b-catenin-signaling and high-grade expression of cancer stem cell markers correlate with metastasis to the liver, but not to the CNS.	26092596
Specialty Type - cancer	Stem Cell Exhaustion	In the present study, we found endogenous and secretory annexin A3 (ANXA3) to play pivotal roles in promoting cancer and stem cell-like features in CD133+ liver CSCs through a dysregulated JNK pathway.	26095609
Liver carcinoma, Neoplasms, Specialty Type - cancer, Hollings Cancer Center	Stem Cell Exhaustion	Frequent tumor relapse in hepatocellular carcinoma (HCC) has been commonly attributed to the presence of residual cancer stem cells (CSCs) after conventional treatments.	26095609
Malignant Neoplasms	Stem Cell Exhaustion	Zinc-finger protein X-linked (ZFX), a novel transcription factor required for self-renewal of embryonic stem cells, has recently been implicated in the initiation and progression of various human malignancies.	26097576
Malignant Neoplasms	Stem Cell Exhaustion	Stem cell transplant (SCT), considered the current standard of care for adults with advanced cancers, can lead to substantial deconditioning and diminished well-being.	26098401
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	High-dose melphalan (MEL) is the standard therapy for autologous stem cell transplantation (ASCT) in multiple myeloma (MM), although the optimal conditioning regimen remains yet to be identified.	26099830
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Superiority of allogeneic hematopoietic stem cell transplantation to nilotinib and dasatinib for adult patients with chronic myelogenous leukemia in the accelerated phase.	26100855
Lymphoma	Stem Cell Exhaustion	Prognostic value of Positron Emission Tomography/Computed Tomography in patients with Lymphoma treated with autologous stem cell transplantation (ASCT) for relapsed/refractory or high risk disease.	26101430
Lymphoma	Stem Cell Exhaustion	Positron Emission Tomography/Computed Tomography (PET/CT scan) has increasingly been used for management of lymphoma, however few and conflicting data have been provided in the setting of high dose therapy with autologous stem cell transplantation (ASCT) so far.	26101430
Liver Cirrhosis, RPS19 gene	Stem Cell Exhaustion	Successful use of reduced-intensity conditioning and matched-unrelated hematopoietic stem cell transplant in a child with Diamond-Blackfan anemia and cirrhosis.	26103586
Morular Metaplasia of the Endometrium, Multiple Myeloma, Communicable Diseases	Stem Cell Exhaustion	We defined the epidemiology and clinical predictors of infection in patients with multiple myeloma (MM) receiving immunomodulatory drugs (IMiDs), proteasome inhibitors (PI) and autologous haematopoietic stem cell transplant (ASCT) in a large longitudinal cohort study.	26105211
Prostate carcinoma, Androgen-sensitive	Stem Cell Exhaustion	These findings identify loss of miR-34b as a robust biomarker for prostate cancer progression in androgen-sensitive tumors, and anticipate a potential role of progenitor/stem cell signaling in this stage of disease.	26107383
Multiple Myeloma	Stem Cell Exhaustion	Changes in circulating endothelial progenitor cells predict responses of multiple myeloma patients to treatment with bortezomib and dexamethasone.	26108099
Lymphoma	Stem Cell Exhaustion	Salvage chemotherapy and autologous stem cell transplantation for transformed indolent lymphoma: a subset analysis of NCIC CTG LY12.	26109202
HYPERPIGMENTATION, FAMILIAL PROGRESSIVE	Stem Cell Exhaustion	IFNL induction was studied in primary human hepatocytes (PHH) from 18 human donors, peripheral blood mononuclear cells (PBMCs) from 18 human donors, multiple cell lines and induced pluripotent stem cell-derived hepatocyte-like cells (iPSC-hepatocytes) from 7 human donors.	26109548
Celiac Disease	Stem Cell Exhaustion	A 37-year-old woman with refractory coeliac disease type II disease treated by stem cell transplantation.	26109624
Liver Carcinosarcoma	Stem Cell Exhaustion	A liver progenitor cell origin of the liver carcinosarcoma was proposed.	26109824
Hollings Cancer Center, Aggressive behavior, Specialty Type - cancer	Stem Cell Exhaustion	Taken together, our results support the conclusion that gSMA expression in HCC is strongly correlated with the EMT process, HCC aggressiveness and the identification of cancer stem cells.	26110787
Neoplasms	Stem Cell Exhaustion	Interestingly, this expression was significantly correlated with poor tumour differentiation and progenitor cell features characterized by the expression of EpCAM and K19.	26110787
Degenerative polyarthritis	Stem Cell Exhaustion	Mesenchymal stem cell implantation in knee osteoarthritis: an assessment of the factors influencing clinical outcomes.	26113522
Degenerative polyarthritis	Stem Cell Exhaustion	Several clinical studies have reported on cell-based treatment using mesenchymal stem cells (MSCs) for cartilage regeneration in knee osteoarthritis (OA).	26113522
Keratopathy, Fibrosis Assessment	Stem Cell Exhaustion	Slit lamp examination revealed diffuse conjunctivalisation of the ocular surface with mild subepithelial fibrosis consistent with aniridic keratopathy secondary to limbal stem cell deficiency.	26113596
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	These tumors may include a malignant heterologous component that is believed to originate through a process of multidirectional differentiation from a cancer stem cell.	26113664
diabetic, Diabetic Retinopathy	Stem Cell Exhaustion	Expression of Angiogenic MicroRNAs in Endothelial Progenitor Cells From Type 1 Diabetic Patients With and Without Diabetic Retinopathy.	26114486
GDC Disease Response Terminology, Diabetes Mellitus, Insulin-Dependent, IGHD1-7 gene, Diabetic Retinopathy	Stem Cell Exhaustion	MicroRNA (miR) expression in endothelial progenitor cells (EPCs) in type 1 diabetes (DM1) and its relation with different stages of diabetic retinopathy (DR) have not been reported to date.	26114486
Specialty Type - cancer	Stem Cell Exhaustion	Epigenetic reprogramming that imparts functional changes in gene expression, the development of cancer stem cells, and immunomodulation are plausible underlying mechanisms by which early-life iAs exposure elicits latent carcinogenic effects.	26115410
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation in elderly patients (>= 70 years) with non-Hodgkin's lymphoma: A French Society of Bone Marrow Transplantation and Cellular Therapy retrospective study.	26116168
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Limited data is available on the feasibility of high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (AHSCT) in elderly patients over 70 years of age with non-Hodgkin's lymphoma (NHL).	26116168
nervous system disorder	Stem Cell Exhaustion	Umbilical cord mesenchymal stem cells in neurological disorders: A clinical study.	26118125
Neoplasms	Stem Cell Exhaustion	The tumor demonstrated robust immunohistochemical expression of multiple markers of embryonic/neural stem cells and embryogenesis from the paraffin embedded tissue.	26118758
Interstitial keratitis, Corneal Opacity	Stem Cell Exhaustion	In addition to previously reported crystalline, nummular, patch-like, and lattice-like corneal opacities, prominent corneal vascularization was present in 2 patients mimicking interstitial keratitis and limbal stem cell deficiency.	26118999
Specialty Type - cancer, Multiple Myeloma	Stem Cell Exhaustion	Multiple myeloma is an incurable cancer commonly treated with stem cell transplantation (SCT).	26119495
Intrahepatic bile duct, Fibrosis of bile duct	Stem Cell Exhaustion	We aimed to study the biliary tree stem cell compartment located in peribiliary glands of extrahepatic and large intrahepatic bile ducts and its role in the pathogenesis of biliary fibrosis in PSC.	26119688
Fibrosis Assessment	Stem Cell Exhaustion	The biliary tree stem cell compartment is activated in PSC, its activation contributes to biliary fibrosis, and is sustained by the Hedgehog pathway.	26119688
Cholangitis	Stem Cell Exhaustion	Activation of biliary tree stem cells within peribiliary glands in primary sclerosing cholangitis.	26119688
Biliary hyperplasia	Stem Cell Exhaustion	Hyperplasia of peribiliary glands was determined by the expansion of biliary tree stem cells, which sprouted towards the surface epithelium.	26119688
Childhood Breast Carcinoma	Stem Cell Exhaustion	It has been shown that the mammary luminal lineage could be maintained by luminal stem cells or long-lived progenitors, but their identity and role in breast cancer remain largely elusive.	26120057
Multiple Myeloma	Stem Cell Exhaustion	Salvage bortezomib-dexamethasone and high-dose melphalan (HDM) and autologous stem cell support (ASCT) in myeloma patients at first relapse after HDM with ASCT.	26121108
Graft-vs-Host Disease	Stem Cell Exhaustion	Lower dose anti-thymocyte globulin for GvHD prophylaxis results in improved survival after allogeneic stem cell transplantation.	26121111
Bronchiolitis Obliterans	Stem Cell Exhaustion	The efficacy of prophylactic azithromycin on bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation.	26121954
Bronchiolitis Obliterans, Bosnian language	Stem Cell Exhaustion	The aim of this study was to determine whether prophylactic azithromycin treatment prevents bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplantation (HCT).	26121954
Neoplasms	Stem Cell Exhaustion	We demonstrated that elevated CRMP5 promotes Notch receptor expression and Akt activation in human tumor cell lines, GBM stem cells, and primary tumor biopsies.	26122847
Coronary Arteriosclerosis	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs), which may be obtained from the bone marrow, have been studied for more than a decade in the setting of coronary artery disease (CAD).	26123356
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	The cancer stem cell hypothesis postulates that a minute fraction of cells within a tumor, termed cancer stem cells (CSCs), have a tumor-initiating capacity that propels tumor growth.	26124098
Specialty Type - cancer	Stem Cell Exhaustion	Drug-eluting microarrays to identify effective chemotherapeutic combinations targeting patient-derived cancer stem cells.	26124098
Non-alcoholic Fatty Liver Disease, Inflammation	Stem Cell Exhaustion	Portal inflammation during NAFLD is frequent and associated with the early phases of putative hepatic progenitor cell activation.	26124313
Non-alcoholic Fatty Liver Disease, Inflammation	Stem Cell Exhaustion	We investigated whether portal tract inflammation observed in non-alcoholic fatty liver disease (NAFLD) is associated with hepatic progenitor cell compartment activation, as thoroughly evaluated with different markers of the staminal lineage.	26124313
Interlobular bile duct	Stem Cell Exhaustion	Putative hepatic progenitor cells, intermediate hepatobiliary cells and bile ductules/interlobular bile ducts were evaluated by immunohistochemistry for cytokeratin (CK)-7, CK-19 and epithelial cell adhesion molecule (EpCAM), and a hepatic progenitor cell compartment score was derived.	26124313
Inflammation, Portal inflammation	Stem Cell Exhaustion	Lobular inflammation, ballooning, myofibroblast activity and hepatic progenitor cell compartment activation were associated with portal inflammation by univariate analysis.	26124313
Portal inflammation	Stem Cell Exhaustion	In the multivariate model, the only variable independently associated with portal inflammation was hepatic progenitor cell compartment activation (OR 3.7, 95% CI 1.1 to 12.6).	26124313
Interlobular bile duct, Inflammation	Stem Cell Exhaustion	Portal inflammation correlated with CK-7-counted putative hepatic progenitor cells (r=0.48, p<0.001), intermediate hepatobiliary cells (r=0.6, p<0.001) and bile ductules/interlobular bile ducts (r=0.6, p<0.001), and with the activity of myofibroblasts (r=0.5, p<0.001).	26124313
Non-alcoholic Fatty Liver Disease, Fibrosis Assessment, Inflammation	Stem Cell Exhaustion	Portal inflammation is frequent during NAFLD and strongly associated with activation of putative hepatic progenitor cells since the first steps of their differentiation, portal myofibroblast activity and fibrosis.	26124313
Esophageal carcinoma	Stem Cell Exhaustion	We examined two receptor tyrosine kinases, platelet-derived growth factor receptor (PDGFR-a) and mast/stem cell growth factor receptor (CD117) in esophageal carcinomas.	26124324
Erythema, Fungal pneumonia, Leukemia, Myelocytic, Acute, Necrosis, Leukocytosis	Stem Cell Exhaustion	We report the case of a 52-year-old man with primary refractory acute myelogenous leukemia (AML) following allogeneic stem cell transplant (SCT) who presented with a progressive reddish purple nodule with surrounding erythema and central necrosis in the setting of leukocytosis and possible fungal pneumonia.	26125209
Neutropenia, Liver Failure, Kidney Failure, Acute, Candidiasis, Neoplasms, Immunocompromised Host	Stem Cell Exhaustion	Patients with invasive Candida infections were more likely to have had an immunocompromised state, hematopoietic stem cell transplantation, solid organ transplant, solid tumor, chemotherapy within the past three months, neutropenia, surgery within the past 30 days, acute renal failure, liver failure, and/or median baseline serum creatinine.	26125894
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Myelodysplastic Syndromes (MDS) are a group of clonal hematopoietic stem cell disorders with significant heterogeneity in their clinical presentation and the prognosis of the patients.	26126819
Acute leukemia	Stem Cell Exhaustion	The interleukin-3 receptor a-chain (CD123) is highly expressed on the surface of acute leukemia cells compared with normal hematopoietic stem cells.	26130514
Pterygium	Stem Cell Exhaustion	We describe a novel surgical technique for pterygium removal taking advantage of the properties of amniotic membrane and limbal epithelial stem cells.	26130669
Pterygium	Stem Cell Exhaustion	The minor ipsilateral simple limbal epithelial transplantation technique for the treatment of pterygium requires less tissue than the conventional conjunctival autograft, leaving healthy conjunctiva if needed for another procedure in the future and offers the advantages of epithelial stem cells, which in the long term may reduce the rate of recurrence significantly.	26130669
Toxic effect, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Reduced-intensity conditioning regimens have demonstrated lower toxicity but increased relapse rates in the context of allogeneic hematopoietic stem cell transplantation (aSCT) for patients with acute myelogenous leukemia (AML).	26132980
Neutropenia	Stem Cell Exhaustion	Fluoroquinolones are widely used for antibacterial prophylaxis during neutropenia following hematopoietic stem cell transplantation (HSCT).	26134140
Neoplasms	Stem Cell Exhaustion	Promoters of genes marked by polycomb in embryonic stem cells were methylated de novo in tumors and identified patients with poor prognosis.	26134223
Thrombasthenia	Stem Cell Exhaustion	Stem Cell Transplant in Severe Glanzmann Thrombasthenia in an Adult Patient.	26134714
Thrombasthenia	Stem Cell Exhaustion	A literature search showed 18 previously reported cases of Glanzmann thrombasthenia treated with allogeneic hematopoietic stem cell transplant.	26134714
Thrombasthenia	Stem Cell Exhaustion	We report an 18-year-old woman with severe Glanzmann thrombasthenia who was treated with allogeneic hematopoietic stem cell transplant from her sister.	26134714
Burn injury	Stem Cell Exhaustion	This process activated cell proliferation in the tissue and, interestingly, in the bulge region of the HF, a major reservoir of epidermal stem cells, promoting hair growth, as well as stimulating tissue repair after severe burn injury.	26134949
Loss of Chromosome 5q	Stem Cell Exhaustion	(1) for abnormalities of +8, 5q-/-5, 20q-/-20 or chromosome 7 involvements, clonal cells above the baseline level were detected in the pluripotent stem cell level.	26135215
Myelodysplastic Syndrome Clone	Stem Cell Exhaustion	It seems that the all malignant MDS clones originated at the pluripotent hematopoietic stem cell stage and that the proliferation and differentiation potencies were retained partly in these clonal cells.	26135215
Heart failure	Stem Cell Exhaustion	Allogeneic Mesenchymal Stem Cells Restore Endothelial Function in Heart Failure by Stimulating Endothelial Progenitor Cells.	26137590
Heart failure, Endothelial dysfunction	Stem Cell Exhaustion	Endothelial dysfunction, characterized by diminished endothelial progenitor cell (EPC) function and flow-mediated vasodilation (FMD), is a clinically significant feature of heart failure (HF).	26137590
Cytomegalovirus Infections	Stem Cell Exhaustion	Cytomegalovirus infection induces a stem cell phenotype in human primary glioblastoma cells: prognostic significance and biological impact.	26138445
Glioblastoma Multiforme Pathway, Neoplasms	Stem Cell Exhaustion	Unfortunately, this standard therapy does not target glioma cancer stem cells (GCSCs), a subpopulation of GBM cells that can give rise to recurrent tumors.	26138445
Hematopoietic stem cells, T-Cell Lymphoma	Stem Cell Exhaustion	Infused autograft lymphocyte-to-monocyte ratio and survival in T-cell lymphoma post-autologous peripheral blood hematopoietic stem cell transplantation.	26138828
Lymphoma, Hemopoietic stem cell transplant	Stem Cell Exhaustion	The infused autograft lymphocyte-to-monocyte ratio (A-LMR) is a prognostic factor for survival in B-cell lymphomas post-autologous peripheral hematopoietic stem cell transplantation (APHSCT).	26138828
Multiple Myeloma	Stem Cell Exhaustion	High-dose melphalan with autologous stem cell support improves survival for patients with myeloma.	26141214
Multiple Myeloma	Stem Cell Exhaustion	Carefully selected patients receiving an autologous stem cell transplant for treatment of myeloma can be managed with a brief initial hospitalization and outpatient follow-up, with low morbidity and mortality.	26141214
Mantle cell lymphoma	Stem Cell Exhaustion	Non-myeloablative allogeneic hematopoietic stem cell transplantation for adults with relapsed and refractory mantle cell lymphoma: a single-center analysis in the rituximab era.	26146802
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation for poor-risk CLL: dissecting immune-modulating strategies for disease eradication and treatment of relapse.	26146810
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	To elucidate factors contributing to the effectiveness of allogeneic hematopoietic stem cell transplantation (alloHCT) in high-risk CLL, immune interventions, GvHD and clinical outcome of 77 consecutive patients allografted for CLL were analyzed.	26146810
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation in adults with myelodysplastic syndrome: Experience of the Argentinean Group of Bone Marrow Transplantation (GATMO).	26147089
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (AHSCT) is a curative approach for patients with myelodysplastic syndrome (MDS).	26147089
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Aldehyde dehydrogenase 1 (ALDH1) is widely used as a specific cancer stem cell marker in a variety of cancers, and may become a promising target for cancer therapy.	26148881
Ovarian Carcinoma, Malignant neoplasm of ovary, Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	High expression of cancer stem cell marker ALDH1 in ovarian carcinoma cells may thus portend a favorable prognosis, but its expression in tumor microenvironment may have no role in tumor behavior of ovarian carcinomas.	26148881
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The importance of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for survival outcomes in patients with acute myeloid leukemia (AML) currently remains unclear.	26149802
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Assessing the efficacy of allogeneic hematopoietic stem cells transplantation (allo-HSCT) by analyzing survival end points in defined groups of acute myeloid leukemia patients: a retrospective, multicenter Polish Adult Leukemia Group study.	26149802
F9 wt Allele	Stem Cell Exhaustion	Moreover, PTC spheres express higher levels of stem cell markers and lower levels of thyroid-specific genes compared with NT spheres.	26151334
Thyroid carcinoma, Specialty Type - cancer, Malignant Neoplasms, Malignant neoplasm of thyroid	Stem Cell Exhaustion	Cancer stem cells from several human malignancies, including poorly differentiated thyroid carcinoma and thyroid cancer cell lines, have been cultured in vitro as sphere-forming cells.	26151334
Neoplasms, Malignant neoplasm of thyroid	Stem Cell Exhaustion	These thyroid cancer stem cells were proven to be able to reproduce the original tumor in a xenograft orthotopic model.	26151334
Hematologic Neoplasms, Neoplasms	Stem Cell Exhaustion	Survival at 90 days post diagnosis was 71.4% in the solid tumour cohort, 62.5% in patients with solid organ transplants, 43.5% in haematological malignancy (HMs) and 37% in those undergoing allogeneic haematopoietic stem cell transplantation (HSCT).	26152371
Alzheimers Disease	Stem Cell Exhaustion	GDF-15 secreted from human umbilical cord blood mesenchymal stem cells delivered through the cerebrospinal fluid promotes hippocampal neurogenesis and synaptic activity in an Alzheimer's disease model.	26154268
Up, "Alzheimers Disease	Stem Cell Exhaustion	Our previous studies demonstrated that transplantation of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) into the hippocampus of a transgenic mouse model of Alzheimer's disease (AD) reduced amyloid-b (Ab) plaques and enhanced cognitive function through paracrine action.	26154268
Hematologic Neoplasms, Fungemia	Stem Cell Exhaustion	So, we report our 6-year surveillance study of fungaemia among patients with haematological malignancies and haematopoietic stem cell transplant.	26155743
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	ATII cells acting as multifunctional stem cells might transform into NSCLC after undergoing exogenous or endogenous factors.	26156586
Usual Severity Pain	Stem Cell Exhaustion	Total and rate of pain reduction were linked to mesenchymal stem cell concentration through 12 months.	26156727
precancerous lesions, Malignant neoplasm of esophagus	Stem Cell Exhaustion	In this study, we investigated CA9 expression in esophageal cancers and in precancerous lesions and explored the association of CA9 expression with prognostic factors and with stem cell and tumorigenesis-related markers including BMI1, cyclin E, ki67, MCM4 and MCM7 expression.	26156831
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	We recently demonstrated that epicardial progenitor cells participate in the regenerative response to myocardial infarction (MI) and factors released in the pericardial fluid (PF) may play a key role in this process.	26159041
Antilymphocyte Serum	Stem Cell Exhaustion	The ability of hUCB plasma to modulate the mitogen cell response and reduce caspase activity suggests that the use of hUCB plasma alone, or with stem cells, may prove useful as a therapeutic in ALS patients.	26159164
Celiac Disease	Stem Cell Exhaustion	Circulating hematopoietic stem cells and putative intestinal stem cells in coeliac disease.	26160352
Celiac Disease	Stem Cell Exhaustion	The intestinal stem cells (ISC) modulation and the role of circulating hematopoietic stem cells (HSC) in coeliac disease (CD) are poorly understood.	26160352
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Aldehyde dehydrogenase 1A1 (ALDH1A1) is considered to be a cancer stem cell marker in several human malignancies.	26160842
Specialty Type - cancer, Hollings Cancer Center	Stem Cell Exhaustion	In this study, we investigated the relationship between ALDH1A1 and clinicopathological findings and examined whether ALDH1A1 deserves to be a cancer stem cell marker in HCC.	26160842
Specialty Type - cancer, Hollings Cancer Center	Stem Cell Exhaustion	In double-staining IHC, ALDH1A1 was not co-expressed with BMI1, EpCAM, CD13, CD24, CD90 and CD133, which reported as cancer stem cell markers in HCC.	26160842
Specialty Type - cancer, Hollings Cancer Center	Stem Cell Exhaustion	In conclusion, ALDH1A1-overexpressing cells could appear to be differentiated cells rather than cancer stem cells in HCC.	26160842
Liver carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	ALDH1A1-overexpressing cells are differentiated cells but not cancer stem or progenitor cells in human hepatocellular carcinoma.	26160842
Acute myocardial infarction	Stem Cell Exhaustion	Intracoronary infusion of Wharton's jelly-derived mesenchymal stem cells in acute myocardial infarction: double-blind, randomized controlled trial.	26162993
Malignant Peripheral Nerve Sheath Tumor, Myeloproliferative disease	Stem Cell Exhaustion	Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by proliferation of one or more myeloid lineages.	26163633
Ulcer	Stem Cell Exhaustion	The implementation of mesenchymal stem cell techniques for treatment of chronic ulcer is feasible.	26164137
Diabetes Mellitus, Ulcer	Stem Cell Exhaustion	[Autologous mesenchymal stem cells and cutaneus autograft as a treatment for chronic ulcer secondary to diabetes mellitus 2].	26164137
Ulcer	Stem Cell Exhaustion	Mesenchymal stem cells have emerged as a promising cell source for the treatment of these ulcers.	26164137
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Biodistribution of 18F-FDG-Labeled Autologous Bone Marrow-Derived Stem Cells in Patients With Type 2 Diabetes Mellitus: Exploring Targeted and Intravenous Routes of Delivery.	26164170
diabetic	Stem Cell Exhaustion	The study aims to carry out in vivo tracking of stem cells labeled with positron emission tomography (PET) tracer fluorine 18-fluorodeoxyglucose (F-FDG) and find adequate administration methods for these cells in diabetic patients.	26164170
Diabetes Mellitus	Stem Cell Exhaustion	The labeled stem cells were given in a total of 21 type 2 diabetes mellitus patients comprising 3 groups of 7 patients each.	26164170
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft versus host disease (GvHD) is a clinically important complication after allogeneic hematopoietic stem cell transplantation (HSCT).	26164839
Mixed Salivary Gland Tumor, Carcinoma	Stem Cell Exhaustion	The Stem Cell Marker Bmi-1 Is Sensitive in Identifying Early Lesions of Carcinoma ex Pleomorphic Adenoma.	26166073
Mixed Salivary Gland Tumor, Carcinoma	Stem Cell Exhaustion	In the present study, we evaluated and described the sensitivity of the stem cell marker B cell-specific moloney murine leukemia virus integration site 1 (Bmi-1) in identifying early lesions of carcinoma ex pleomorphic adenoma (CXPA).	26166073
Toxic effect	Stem Cell Exhaustion	BEAM Conditioning Regimen Has Higher Toxicity Compared With High-Dose Melphalan for Salvage Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma.	26166312
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Salvage autologous stem cell transplantation (ASCT) is increasingly used for eligible patients with multiple myeloma (MM) for progress after conventional chemotherapy.	26166312
Lymphoma, Follicular	Stem Cell Exhaustion	Favorable survival after allogeneic stem cell transplantation with reduced-intensity conditioning regimens for relapsed/refractory follicular lymphoma.	26168068
Lymphoma, Follicular	Stem Cell Exhaustion	Allogeneic stem cell transplantation (allo-SCT) is a curative option for patients with relapsed follicular lymphoma (FL).	26168068
Triple-Negative Breast Cancer Finding, Childhood Breast Carcinoma	Stem Cell Exhaustion	Triple-negative breast cancer (TNBC) is a heterogeneous group of disease with a well-known association with epithelial-mesenchymal transition (EMT) and breast cancer stem cell phenotype.	26170011
Childhood Breast Carcinoma, Neoplasms	Stem Cell Exhaustion	We analyzed immunohistochemical expression of EMT-related markers, including EMT markers (expression of vimentin, smooth muscle actin, osteonectin, and N-cadherin; loss of E-cadherin), EMT inducers (ZEB1 and CD146), and breast cancer stem cell markers (CD44(+)/CD24(-) and aldehyde dehydrogenase 1) in 173 TNBCs and correlated their expression with clinicopathological features of the tumors, including clinical outcome.	26170011
Malignant neoplasm of liver	Stem Cell Exhaustion	LncRNA HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2.	26172293
Malignant neoplasm of liver	Stem Cell Exhaustion	Herein, we demonstrate HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2.	26172293
Malignant neoplasm of liver	Stem Cell Exhaustion	This study provides evidence for HOTAIR to promote tumorigenesis via downregulating SETD2 in liver cancer stem cells.	26172293
Malignant neoplasm of urinary bladder	Stem Cell Exhaustion	Together these findings implicate variants in the Wnt/b-catenin stem cell pathway as having a role in bladder cancer etiology.	26173102
Mobilized Peripheral Blood Stem Cell, Multiple Myeloma	Stem Cell Exhaustion	Comparison of biosimilar filgrastim with originator filgrastim for peripheral blood stem cell mobilization and engraftment in patients with multiple myeloma undergoing autologous stem cell transplantation.	26173921
Wernicke-Korsakoff Syndrome, Central neuroblastoma	Stem Cell Exhaustion	Stem Cell Transplant-Associated Wernicke Encephalopathy in a Patient with High-Risk Neuroblastoma.	26174546
Cerebellar Ataxia, Central neuroblastoma, Tachycardia by ECG Finding	Stem Cell Exhaustion	We present the case of a 5-year-old patient with stage 4, high-risk neuroblastoma who developed altered mental status, ataxia, and tachycardia during consolidative autologous stem cell transplantation.	26174546
Childhood Breast Carcinoma	Stem Cell Exhaustion	Stem cell biomarker ALDH1A1 in breast cancer shows an association with prognosis and clinicopathological variables that is highly cut-off dependent.	26175266
Childhood Breast Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Aldehyde dehydrogenase family 1 member A1 (ALDH1A1) is a putative marker of breast cancer stem cells (CSCs) with prognostic implications when expressed in cancer or stroma.	26175266
Gallbladder adenocarcinoma	Stem Cell Exhaustion	Prognostic Value of the Stem Cell Markers Epcam and CD133 Expression Of Gallbladder Adenocarcinoma.	26176038
Malignant Lesion	Stem Cell Exhaustion	To investigate the expressions and prognostic value of stem cell markers, EpCAM and CD133, in benign and malignant lesions of gallbladder.	26176038
HIV Infections	Stem Cell Exhaustion	Proliferation of neural progenitor cells in the dentate gyrus was increased in HIV infection (P = 0.028), whereas the density of recently generated TUC-4 [TOAD (turned on after division)/Ulip/CRMP family 4]-expressing neurons in this region was not significantly elevated in HIV-infected cases (P = 0.13).	26176591
Heart failure	Stem Cell Exhaustion	Current interventions range from conservative heart failure management to autologous stem cell and heart transplantation.	26177555
Diarrhea	Stem Cell Exhaustion	Colonoscopy and Sigmoidoscopy are Equally Effective for the Diagnosis of Colonic Acute Graft-versus-Host Disease in Patients with Diarrhea after Allogeneic Stem Cell Transplantation: A Prospective Controlled Trial.	26183080
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Colonic acute graft-versus-host disease (aGVHD) affects approximately 10% of patients who have undergone allogeneic stem cell transplantation (allo-SCT).	26183080
Cessation of life, Scleroderma Renal Crisis, Malignant Neoplasms, Purpura, Thrombotic Thrombocytopenic	Stem Cell Exhaustion	After excluding deaths from scleroderma renal crisis (100% mortality), malignancy (75% mortality) and stem cell transplant (50% mortality), the survival rate for secondary TTP was 85%.	26183258
Neoplasms	Stem Cell Exhaustion	On the other hand, all tumor cells were positive for CD133, Musashi1, and SOX-2 which are the markers of neural stem cells.	26183264
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	These results also indicated that pluripotential cancer stem cells differentiated into glial and muscle cell lines at the time of tumor growth.	26183264
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The application of allogeneic stem cell transplantation increased over time among AML patients up to age 70 years.	26183645
Hemoglobinuria, CTCAE 3.0, Multiple Myeloma	Stem Cell Exhaustion	Significance of the detection of paroxysmal nocturnal hemoglobinuria clones in patients with multiple myeloma undergoing autologous stem cell transplantation.	26183672
Central nervous system complication	Stem Cell Exhaustion	Central nervous system complications (CNSC) can be the cause of morbidity and mortality in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT).	26184063
SERPINB3 wt Allele, Specialty Type - cancer	Stem Cell Exhaustion	Silencing shJARID1B significantly inhibited oral cancer stem cell activity and potentiated the tumor-inhibitory activity of radiation therapy in OSCC.	26184998
SERPINB3 wt Allele, Specialty Type - cancer	Stem Cell Exhaustion	Silencing shJARID1B inhibits migration and invasion of human OSCC, reduces cancer stem cell activities and potentiates tumor-inhibiting radiotherapeutic effects.	26184998
Specialty Type - cancer	Stem Cell Exhaustion	Each line mainly included EpCAM-positive cells and cells expressing putative cancer stem cell markers such as CD133, CD44, CD24, ALDH1, and LGR5.	26185002
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Cytoplasmic expression of RBMY, which is mediated by binding to nuclear exporter chromosome region maintenance 1 and further enriched upon Wnt-3a stimulation, confers upon tumor cells the traits of cancer stem cell by augmenting self-renewal, chemoresistance, cell-cycle progression, proliferation, and xenograft tumor growth.	26185016
Hollings Cancer Center, Malignant neoplasm of liver, Hepatocarcinogenesis	Stem Cell Exhaustion	Upon hepatocarcinogenesis, a noteworthy increase of cytoplasmic and nuclear RBMY is observed in HCC tissues; however, only the former is expressed dominantly in hepatic cancer stem cells and correlates significantly to a poor prognosis and decreased survival rate in HCC patients.	26185016
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	The purpose of our study is to determine the outcome of patients with systemic non-Hodgkin lymphoma presenting with neurologic localization at diagnosis, as well as the impact of consolidation in terms of high-dose therapy followed by autologous stem cell transplantation.	26185174
Malignant Neoplasms	Stem Cell Exhaustion	Stem cells, aging and cancers.	26186894
Neoplasms	Stem Cell Exhaustion	Whether these two neoplasms were related is unclear; however, if so, we suspect the combination might be caused by a malignant transformation of a promonocyte or stem cell, upstream of histiocytes and monocytes.	26187047
Ki-1+ Anaplastic Large Cell Lymphoma	Stem Cell Exhaustion	A non-NPM1 fusion partner of ALK was identified in a 32-year-old Caucasian male ALCL patient whose disease was refractory to standard chemotherapy and autologous stem cell transplantation, and exhibited a poor response to a first-generation ALK inhibitor.	26187744
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	CD34-Selected Hematopoietic Stem Cell Transplants Conditioned with Myeloablative Regimens and Antithymocyte Globulin for Advanced Myelodysplastic Syndrome: Limited Graft-versus-Host Disease without Increased Relapse.	26187863
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only curative therapy for patients with myelodysplastic syndrome (MDS).	26187863
Memory impairment	Stem Cell Exhaustion	Wharton's Jelly-derived mesenchymal stem cells alleviate memory deficits and reduce amyloid-b deposition in an APP/PS1 transgenic mouse model.	26188488
nervous system disorder	Stem Cell Exhaustion	Wharton's Jelly-derived mesenchymal stem cells (WJ-MSCs) have a potential therapeutic effect in the treatment for neurological diseases.	26188488
Liver carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	MiR-491 attenuates cancer stem cells-like properties of hepatocellular carcinoma by inhibition of GIT-1/NF-kB-mediated EMT.	26188902
Multiple Myeloma	Stem Cell Exhaustion	Efficacy of biosimilar granulocyte colony-stimulating factor versus originator granulocyte colony-stimulating factor in peripheral blood stem cell mobilization in de novo multiple myeloma patients.	26188967
Mobilized Peripheral Blood Stem Cell	Stem Cell Exhaustion	Filgrastim and lenograstim are the standard granulocyte colony-stimulating factor (G-CSF) agents for peripheral blood stem cell mobilization (PBSC) in patients who undergo autologous stem cell transplantation.	26188967
Gastrointestinal mucositis, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	An oral care self-management support protocol (OrCaSS) to reduce oral mucositis in hospitalized patients with acute myeloid leukemia and allogeneic hematopoietic stem cell transplantation: a randomized controlled pilot study.	26190359
Gastrointestinal mucositis, Oman	Stem Cell Exhaustion	Oral mucositis (OM) is a common and debilitating side effect of chemoradiotherapy in patients awaiting allogeneic hematopoietic stem cell transplantation (aHSCT).	26190359
Multiple Myeloma	Stem Cell Exhaustion	Clinical features and survival of 338 multiple myeloma patients treated with hematopoietic stem cell transplantation or conventional chemotherapy.	26190662
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Musashi-1, a RNA-binding protein, is suggested to be a cancer stem cell-related marker; its high level of protein expression is reported to be associated with high histological grade in some tumors.	26191146
Specialty Type - cancer	Stem Cell Exhaustion	Furthermore, we examined whether Musashi-1 expression is correlated with another cancer stem cell marker CD133 by real-time RT-PCR.	26191146
Colonic Neoplasms	Stem Cell Exhaustion	Occurrence of colon tumors in a 16-year-old Japanese boy after hematopoietic stem cell transplantation for Diamond Blackfan anemia at age of 4: a case report.	26191323
Colonic Neoplasms	Stem Cell Exhaustion	Here, we report a case of a 16-year-old Japanese boy suffering from multiple colon tumors during the follow-up after hematopoietic stem cell transplantation for DBA at the age of 4.	26191323
Pulmonary arterial hypertension	Stem Cell Exhaustion	Endothelial NO-Synthase Gene-Enhanced Progenitor Cell Therapy for Pulmonary Arterial Hypertension: The PHACeT Trial.	26195220
Pulmonary Hypertension	Stem Cell Exhaustion	The Pulmonary Hypertension and Angiogenic Cell Therapy (PHACeT) trial was a phase 1, dose-escalating clinical study of the tolerability of culture-derived endothelial progenitor cells, transiently transfected with endothelial nitric oxide synthase, in patients with PAH refractory to PAH-specific therapies.	26195220
Dental Pulp Necrosis	Stem Cell Exhaustion	Regenerative endodontic procedures are stem cell-based treatments for immature teeth with pulp necrosis.	26195498
Specialty Type - cancer	Stem Cell Exhaustion	Also, bigger mammals with larger underlying stem cell pools are not proportionally more prone to cancer, an observation known as Peto's paradox.	26195756
Inflammation	Stem Cell Exhaustion	Phenotypic enumeration of colonocytes' subcompartments from patients revealed significant alterations of the lower crypt, enriched in stem cell and progenitors, independent of inflammation.	26197452
Inflammation, Ulcerative Colitis	Stem Cell Exhaustion	Our results thus provide new insights into the development of inflammation and relapse in UC and suggest that the stem cell niche in the colon may influence pathogenesis of the disease.	26197452
Neoplasms	Stem Cell Exhaustion	Bevacizumab/high-dose chemotherapy with autologous stem-cell transplant for poor-risk relapsed or refractory germ-cell tumors.	26199392
Multiple Myeloma, Communicable Diseases	Stem Cell Exhaustion	Incidence of infection according to intravenous immunoglobulin use in autologous hematopoietic stem cell transplant recipients with multiple myeloma.	26201517
Stable chronic Graft vs Host Disease	Stem Cell Exhaustion	Chronic graft versus host disease (cGvHD) is the most common cause of late morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT).	26204824
Chronic total occlusion of coronary artery	Stem Cell Exhaustion	We have evaluated the safety and efficacy of intracoronary human umbilical cord-derived mesenchymal stem cell (hUCMSC) treatment for very old patients with coronary chronic total occlusion.	26205288
Crohn Disease	Stem Cell Exhaustion	Ex vivo immunosuppressive effects of mesenchymal stem cells on Crohn's disease mucosal T cells are largely dependent on indoleamine 2,3-dioxygenase activity and cell-cell contact.	26206376
Spinal Cord Injuries	Stem Cell Exhaustion	Intrathecal transplantation of autologous adipose-derived mesenchymal stem cells for treating spinal cord injury: A human trial.	26208177
Neoplasms	Stem Cell Exhaustion	Maspin-nonexpressing tumor cells that survived the suspension culture in compact tumorspheres displayed a higher level of stem cell marker expression, maintained the self-renewal capacity, formed tumorspheres in 3D matrices in vitro, and were tumorigenic in vivo.	26208903
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	We investigated the effects of sitagliptin, a dipeptidyl peptidase (DPP)-4 inhibitor, on the number of circulating CD34(+)CXCR4(+)cells, a candidate for endothelial progenitor cells (EPCs), plasma levels of stromal cell-derived factor (SDF)-1a, a ligand for CXCR4 receptor and a substrate for DPP-4, and plasma levels of interferon-inducible protein (IP)-10, for a substrate for DPP-4, in patients with type 2 diabetes.	26209038
Antilymphocyte Serum	Stem Cell Exhaustion	Previously, we reported that human bone marrow mesenchymal stromal cells isolated from ALS patients (ALS-MSCs) have functionally decreased stem cell potency, and excessively express DNA methyltransferases (DNMTs).	26210997
SERPINB3 wt Allele, Squamous cell carcinoma, Stable chronic Graft vs Host Disease, Neoplasms, Graft-vs-Host Disease	Stem Cell Exhaustion	Oral squamous cell carcinoma (OSCC) is one of the most common solid tumours occurring after haematopoietic stem cell transplantation (HSCT), especially in patients with chronic graft-versus-host-disease (cGVHD).	26211810
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Cytomegalovirus Reactivation after Allogeneic Hematopoietic Stem Cell Transplantation is Associated with a Reduced Risk of Relapse in Patients with Acute Myeloid Leukemia Who Survived to Day 100 after Transplantation: The Japan Society for Hematopoietic Cell Transplantation Transplantation-related Complication Working Group.	26211985
Clostridium difficile	Stem Cell Exhaustion	Clostridium Difficile Colonization in Hematopoietic Stem Cell Transplant Recipients: A Prospective Study of the Epidemiology and Outcomes Involving Toxigenic and Nontoxigenic Strains.	26211988
Clostridium difficile, Dysentery	Stem Cell Exhaustion	Clostridium difficile is a leading cause of infectious diarrhea in hematopoietic stem cell transplant (HSCT) recipients.	26211988
Hollings Cancer Center	Stem Cell Exhaustion	Using HCC cell lines, we then demonstrated that either TACC3 knockdown or treatment with the potential TACC3 inhibitor KHS101 suppressed cell growth and sphere formation as well as the expression of stem cell transcription factors, including Bmi1, c-Myc and Nanog.	26219398
Specialty Type - cancer	Stem Cell Exhaustion	Silencing TACC3 may suppress the Wnt/b-catenin and PI3K/AKT signaling pathways, which regulate cancer stem cell-like characteristics.	26219398
Hollings Cancer Center, Specialty Type - cancer	Stem Cell Exhaustion	Taken together, these data suggest that TACC3 is enriched in HCC and that TACC3 down-regulation inhibits the proliferation, clonogenicity, and cancer stem cell-like phenotype of HCC cells.	26219398
Adenoma, Pituitary Adenoma	Stem Cell Exhaustion	The present study aimed at the evaluation of Hh signaling in relation to stem cell and cell cycle markers in 30 human pituitary adenomas and in cultured murine adenoma cells.	26219678
Pituitary Adenoma	Stem Cell Exhaustion	Therefore, expression levels of components of the Hh pathway, stem cell marker SOX2, cell cycle regulator tumor-protein 53 (TP53), proliferation marker Ki67 (MKI67) and superoxide dismutase 1 (SOD1) were evaluated in 30 human pituitary adenomas in comparison to control tissue.	26219678
Specialty Type - cancer	Stem Cell Exhaustion	It was found to be aberrantly activated in numerous types of human cancer and might be relevant in cancer stem cells.	26219678
Pituitary Adenoma	Stem Cell Exhaustion	The identification of adult stem cells in the pituitary raised the question if tumor-initiating cells and Hh signaling are involved in pituitary adenoma formation.	26219678
Osteoporosis	Stem Cell Exhaustion	Therefore, it was the aim of the present study to investigate the dynamics of haemopoietic stem cells and corresponding in peripheral blood of 13 patients with osteoporosis during treatment with teriparatide.	26220030
Blood Circulation	Stem Cell Exhaustion	We were able to show that administration of teriparatide is sufficient to mobilise haemopoietic stem cells into the bloodstream accompanied by an alteration of mobilising cytokines.	26220030
Liver carcinoma	Stem Cell Exhaustion	Progenitor cell markers predict outcome of patients with hepatocellular carcinoma beyond Milan criteria undergoing liver transplantation.	26220754
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation could improve survival of cytogenetically normal adult acute myeloid leukemia patients with DNMT3A mutations.	26223865
Cytogenetically normal acute myeloid leukemia	Stem Cell Exhaustion	The role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in DNMT3A(mut) cn-AML patients remains unclear.	26223865
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Resveratrol-downregulated phosphorylated liver kinase B1 is involved in senescence of acute myeloid leukemia stem cells.	26223914
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The aim of this study was to examine the effect of resveratrol-downregulated phosphorylated liver kinase B1 (pLKB1) on the senescence of acute myeloid leukemia (AML) stem cells.	26223914
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	It was concluded that resveratrol-downregulated pLKB1 is involved in the senescence of AML stem cells.	26223914
Muscular Atrophy	Stem Cell Exhaustion	Induced pluripotent stem cells (iPSCs) are a promising tool for regenerative medicine in chronic conditions associated with muscle atrophy since iPSCs are easier to obtain, pose less ethical limitations and can better capture human genetic diversity compared with human embryonic stem cells.	26224204
Dental Plaque	Stem Cell Exhaustion	As cardiovascular mortality relates to plaque instability, which depends on the integrity of the fibrous cap, we hypothesize that the inhibition of the potential of mesenchymal stem cells (MSCs) to differentiate into macrophages would help to explain the long known, but less understood "non-lipid-associated" or pleiotropic benefit of statins on cardiovascular mortality.	26224580
Chronic myeloproliferative disorder, Mastocytosis	Stem Cell Exhaustion	Chronic myeloproliferative diseases are clonal stem cell diseases which occur as a result of uncontrollable growth and reproduction of hematopoietic stem cells, which are the myeloid series source in bone marrow.	26225646
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Human herpesvirus-6 (HHV-6) is known to reactivate after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and may be associated with development of acute graft-versus-host disease (GVHD) and nonrelapse mortality (NRM).	26226409
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We found that miR-320a expression was reduced in K562 and in CML cancer stem cells.	26228085
Acute lymphocytic leukemia	Stem Cell Exhaustion	Regimens for acute lymphoblastic leukemia can be used for management of secondary acute lymphoblastic leukemia with plan for stem cell transplantation.	26228379
TSPYL2 gene, Lymphoma, T-Cell, Cutaneous	Stem Cell Exhaustion	Early-stage cutaneous T-cell lymphoma (CTCL) is a skin-limited lymphoma with no cure aside from stem cell transplantation.	26228486
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation (ASCT) is the standard of care for selected patients with multiple myeloma (MM).	26228581
Graft-vs-Host Disease	Stem Cell Exhaustion	Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey.	26228813
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	PD-1(hi)TIM-3(+) T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation.	26230954
leukemia	Stem Cell Exhaustion	Prognosis of leukemia relapse post allogeneic stem cell transplantation (alloSCT) is poor and effective new treatments are urgently needed.	26230954
Angioma, Cavernous, Cerebrovascular accident	Stem Cell Exhaustion	While cavernous angioma (CVA) after cranial irradiation has been documented, its development after high-dose chemotherapy with autologous peripheral blood stem cell transplantation (PBSCT) has not.	26231569
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	USP44+ Cancer Stem Cell Subclones Contribute to Breast Cancer Aggressiveness by Promoting Vasculogenic Mimicry.	26232424
Childhood Breast Carcinoma	Stem Cell Exhaustion	In our previous study, breast cancer stem cells (CSC) were shown to potentially participate in VM formation.	26232424
Autoimmune sensorineural hearing loss	Stem Cell Exhaustion	The paracrine effect of mesenchymal human stem cells restored hearing in b-tubulin induced autoimmune sensorineural hearing loss.	26235980
Autoimmune reaction	Stem Cell Exhaustion	The aim of this study was to examine the activities of hASCs (Human Adipose tissue Derived Stem Cells) on experimental autoimmune hearing loss (EAHL) and how human stem cells regenerated mouse cochlea cells.	26235980
Autoimmune reaction	Stem Cell Exhaustion	We have restored hearing in 19 years old white female with autoimmune hearing loss with autologous adipose tissue derived stem cells and we wish to understand the mechanism of restoration of hearing in animal model.	26235980
Stria Vascularis	Stem Cell Exhaustion	In control group, without receiving stem cells, the organ of Corti is replaced by a single layer of cells, atrophy of stria vascularis.	26235980
Primary Myelofibrosis	Stem Cell Exhaustion	In myelofibrosis, the introduction of reduced-intensity conditioning (RIC) preceding allogeneic stem cell transplantation (SCT) resulted in lower transplant-related mortality rates compared with myeloablative conditioning.	26237165
Malignant Neoplasms	Stem Cell Exhaustion	Fludarabine and treosulfan compared with other reduced-intensity conditioning regimens for allogeneic stem cell transplantation in patients with lymphoid malignancies.	26237166
Malignant Neoplasms	Stem Cell Exhaustion	Allogeneic stem-cell transplantation (SCT) is a potentially curative therapy for lymphoid malignancies.	26237166
Viral Encephalitis	Stem Cell Exhaustion	Viral reactivation following hematopoietic stem cell transplantation (HSCT) can cause various complications especially viral encephalitis.	26241219
Meningioma	Stem Cell Exhaustion	Expression of Stem Cell Marker Nestin and MicroRNA-21 in Meningiomas.	26242334
Specialty Type - cancer	Stem Cell Exhaustion	Leukapheresis is often performed in cancer patients to harvest stem cells, manufacture therapeutic vaccines, or follow immunologic response to therapy.	26243387
Graft-vs-Host Disease	Stem Cell Exhaustion	A cohort of 110 cases of simultaneous UGI and LGI biopsies from 105 allogeneic hematopoietic stem cell transplantation recipients with clinically confirmed GI GVHD were reviewed retrospectively.	26243672
Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8	Stem Cell Exhaustion	Disease modeling of induced pluripotent stem cells (iPSCs) from patients with longstanding T1D (disease duration >= 50 years) with severe (Medalist +C) or absent to mild complications (Medalist -C) revealed impaired growth, reprogramming, and differentiation in Medalist +C.	26244933
Malignant neoplasm of lung, Specialty Type - cancer	Stem Cell Exhaustion	Tyr1068-phosphorylated epidermal growth factor receptor (EGFR) predicts cancer stem cell targeting by erlotinib in preclinical models of wild-type EGFR lung cancer.	26247735
Malignant neoplasm of lung	Stem Cell Exhaustion	Therapeutics validation has necessarily to focus on lung cancer stem cells (LCSCs) as they are more difficult to eradicate and represent the tumor-maintaining cell population.	26247735
Childhood Breast Carcinoma	Stem Cell Exhaustion	Mammosphere formation was used to assess breast cancer stem cell properties.	26248960
Graft-vs-Host Disease	Stem Cell Exhaustion	[Hypofibrinogenemia associated with steroid therapy for the patients who developed GVHD after allogeneic stem cell transplantation].	26251153
Disseminated neuroblastoma, Central neuroblastoma	Stem Cell Exhaustion	However, determining the duration of 13-cis-RA treatment for residual and recurrent neuroblastoma can be a problem because it is difficult to evaluate the effectiveness of the treatment.We performed 13-cis-RA treatment to remove residual active neuroblastoma cells in an 8-year-old boy with stage 4 neuroblastoma that developed from a left sympathetic ganglion and had been treated with chemotherapy, surgery, autologous peripheral blood stem-cell transplantation, and radiotherapy.	26252303
Amyloidosis	Stem Cell Exhaustion	Higher Stem Cell Dose Infusion after Intensive Chemotherapy Does Not Improve Symptom Burden in Older Patients with Multiple Myeloma and Amyloidosis.	26253006
Morular Metaplasia of the Endometrium, Multiple Myeloma, Amyloidosis	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation (ASCT) for multiple myeloma (MM) is associated with high symptom burden, particularly for older patients and those with amyloid light-chain (AL) amyloidosis.	26253006
Specialty Type - cancer, Carcinoma, Transitional Cell	Stem Cell Exhaustion	Cancer stem cell theory plays an important role in the clinical study of transitional cell carcinoma of the upper urinary tract.	26254374
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Radiosensitivity of Patient-Derived Glioma Stem Cell 3-Dimensional Cultures to Photon, Proton, and Carbon Irradiation.	26254681
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	To investigate the radiosensitivity of primary glioma stem cell (GSC) cultures with different CD133 status in a 3-dimensional (3D) model after photon versus proton versus carbon irradiation.	26254681
Vancomycin-Resistant Enterococci, Colonization, Communicable Diseases	Stem Cell Exhaustion	Although several studies have documented adverse outcomes for vancomycin-resistant Enterococcus (VRE) colonization and infection in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients, data are inadequate for patients undergoing autologous (auto-)HSCT.	26256692
Thrombocytosis, Myeloproliferative disease, Primary Myelofibrosis, Malignant Peripheral Nerve Sheath Tumor, Polycythemia Vera, Neoplasms	Stem Cell Exhaustion	Myeloproliferative neoplasms (MPNs) are heterogeneous clonal bone marrow stem cell disorders and include polycythemia vera (PV), essential thrombocythemia (ET), and idiopathic myelofibrosis (IMF) neoplasia.	26256826
T-Cell Lymphoma	Stem Cell Exhaustion	Tet2 mutations induce enhanced self-renewal ability and competitive repopulation capacity in hematopoietic stem cells, and various MPN/MDS-like diseases and T-cell lymphoma consequently develop in model mice.	26256875
Hematologic Neoplasms	Stem Cell Exhaustion	In conclusion, TET2 might play a major role as a gate keeper for hematopoietic stem/progenitor cells preventing them from developing into various hematologic malignancies by acquiring additional disease-specific gene mutations.	26256875
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Management of Myelodysplastic Syndrome Relapsing after Allogeneic Hematopoietic Stem Cell Transplantation: A Study by the French Society of Bone Marrow Transplantation and Cell Therapies.	26256942
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	To find out prognostic factors and to investigate different therapeutic approaches, we report on 147 consecutive patients who relapsed after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for myelodysplastic syndrome (MDS).	26256942
Adult Glioblastoma, Specialty Type - cancer	Stem Cell Exhaustion	Hypoxia-mediated cancer stem cells in pseudopalisades with activation of hypoxia-inducible factor-1a/Akt axis in glioblastoma.	26256949
Specialty Type - cancer	Stem Cell Exhaustion	Hypoxic regions have been proposed as one of several distinct niches for cancer stem cells (CSCs) in GBM, but little is known about the association between Ps features and CSC properties.	26256949
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Nonmyeloablative allogeneic stem cell transplantation for chronic lymphocytic leukaemia offers the possibility of disease control with minimal morbidity and mortality--a single institution experience.	26259502
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Allogeneic stem cell transplantation is a treatment option for patients with poor risk CLL.	26259502
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Our single-centre experience confirms the valuable role of allogeneic stem cell transplantation (allo-SCT) in the treatment of poor risk CLL patients with promising long-term survival and acceptable transplant-related mortality.	26259502
Acute Myeloid Leukemia with FLT3/ITD Mutation	Stem Cell Exhaustion	High rate of hematological responses to sorafenib in FLT3-ITD acute myeloid leukemia relapsed after allogeneic hematopoietic stem cell transplantation.	26260140
Allogeneic Hematopoietic Stem Cell Transplantation, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Relapse represents the most significant cause of failure of allogeneic hematopoietic stem cell transplantation (HSCT) for FLT3-ITD-positive acute myeloid leukemia (AML), and available therapies are largely unsatisfactory.	26260140
Palmar-plantar erythrodysesthesia syndrome, Cytopenia	Stem Cell Exhaustion	Treatment was overall manageable in the outpatient setting, although all patients experienced significant adverse events, especially severe cytopenias (requiring a donor stem cell boost in five patients) and typical hand-foot syndrome.	26260140
Communicable Diseases	Stem Cell Exhaustion	The relative contribution of human cytomegalovirus (HMCV)-specific CD4(+) and CD8(+) T cells to the control of HCMV infection in hematopoietic stem cell transplant (HSCT) recipients is still controversial.	26260678
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute, Acute lymphocytic leukemia	Stem Cell Exhaustion	Phase II Trial of Reduced-Intensity Busulfan/Clofarabine Conditioning with Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Acute Myeloid Leukemia, Myelodysplastic Syndromes, and Acute Lymphoid Leukemia.	26260679
Acute leukemia	Stem Cell Exhaustion	Clofarabine has potent antileukemia activity and its inclusion in reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (HSCT) for acute leukemia could potentially improve outcomes.	26260679
PAFAH1B1 wt Allele, DiGeorge Syndrome	Stem Cell Exhaustion	A 4 year old child with MDS and DiGeorge Syndrome Type 2 was rescued with repetitive whole lung lavages and her PAP was cured with heterologous stem cell transplant.	26264606
Hematologic Neoplasms	Stem Cell Exhaustion	Pretransplant platelet transfusion refractoriness is not associated with platelet nonengraftment in T-replete hematopoietic progenitor cell transplantation for hematologic malignancies.	26264674
Pancreatic carcinoma, Adenocarcinoma of pancreas	Stem Cell Exhaustion	We hypothesized that selected substances, participating in this "dialog," are associated with body mass and peripheral trafficking of bone marrow-derived stem cells (BMSCs) in both healthy individuals and patients with obesity-associated malignancies such as pancreatic adenocarcinoma.We performed an analysis of the systemic levels of selected substances involved in the regulation of bone (marrow) homeostasis (parathormone, calcitonin, osteopontin, osteonectin, stem cell factor [SCF], and fibroblast growth factor-23) in 35 generally healthy volunteers and 35 patients with pancreatic cancer.	26266370
Specialty Type - cancer	Stem Cell Exhaustion	While no significant correlation was observed between BMI and the number of circulating BMSCs in patients with cancer, peripheral trafficking of CD34 + KDR + CD31 + CD45-endothelial progenitor cells and CD105 + STRO-1 + CD45-mesenchymal stem cells was associated with the osteonectin/osteopontin ratio, which also correlated with BMI (r = 0.52; P < 0.05).	26266370
Stem Cell Factor	Stem Cell Exhaustion	Additionally, subcutaneous and visceral/omental AT levels of the aforementioned molecules were analyzed in lean and overweight/obese individuals.Intensified steady-state trafficking of only Lin-CD45 + CD133 + hematopoietic stem/progenitor cells was observed in overweight/obese individuals and this was associated with BMI values and elevated levels of both osteonectin and SCF, which also correlated with BMI.	26266370
Cessation of life, Lymphoma, Non-Hodgkin, Familial, Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	When death in the absence of HBV-RS was considered as the competing risk, the univariate and multivariate regression analyses showed that several factors were independently associated with the development of HBV-RS, including anti-HCV seronegativity, histological subtype of posttransplant lymphoproliferative disorders, >=6 cycles of rituximab therapy, and succeeding hematopoietic stem cell transplantation.The findings of our study identify additional factors influencing the development of rituximab-associated HBV-RS in HBsAg-seronegative adults with CD20 NHL.	26266374
BCR gene	Stem Cell Exhaustion	The results presented here highlight the need for mandatory inclusion of molecular testing for pediatric ALL patients in clinical decision making, together with the incorporation of tyrosine kinase inhibitors, as well as hematopoietic stem cell transplantation facilities, to improve treatment outcome for patients in developing countries.	26266519
Fecal Incontinence	Stem Cell Exhaustion	Implantation of autologous muscle-derived stem cells in treatment of fecal incontinence: results of an experimental pilot study.	26266767
Primary central nervous system lymphoma	Stem Cell Exhaustion	The influence of rituximab, high-dose therapy followed by autologous stem cell transplantation, and age in patients with primary CNS lymphoma.	26268792
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A case of 25-year-male presenting with leukemic BPDCN without cutaneous involvement is presented here, who was treated with AML like protocol followed by hematopoietic stem cell transplantation, but succumbed to the disease within 8 months of diagnosis.	26275271
Adult Glioblastoma	Stem Cell Exhaustion	Glioblastoma recurrence patterns near neural stem cell regions.	26276527
Specialty Type - cancer, Adult Glioblastoma, Neoplasms	Stem Cell Exhaustion	Glioblastoma (GBM) cancer stem cells and their neural stem cell counterparts are hypothesized to contribute to tumor progression.	26276527
Renal Insufficiency, Amyloidosis	Stem Cell Exhaustion	The prognostic factors associated with overall survival were the International Staging System, the serum lactate dehydrogenase level, the renal impairment, the realization of autologous stem cell transplantation, and the presence of concomitant amyloidosis.	26277330
Sepsis, EIF2AK3 wt Allele, Pneumonia	Stem Cell Exhaustion	Sepsis, stem cell transplantation, preexisting pneumonia, or the use of granulocyte colony-stimulating factor were not associated with WRS during NR.	26278709
Diabetes Mellitus, Periodontitis	Stem Cell Exhaustion	DKK1 rescues osteogenic differentiation of mesenchymal stem cells isolated from periodontal ligaments of patients with diabetes mellitus induced periodontitis.	26278788
Inflammation	Stem Cell Exhaustion	Recently mesenchymal stem cells derived from periodontal ligament (PDLSCs) have been utilized to reconstruct tissues destroyed by chronic inflammation.	26278788
Mycoses	Stem Cell Exhaustion	Incidence and risk factors of post-engraftment invasive fungal disease in adult allogeneic hematopoietic stem cell transplant recipients receiving oral azoles prophylaxis.	26281032
B-Cell Lymphomas	Stem Cell Exhaustion	High Doses of Antimetabolites Followed by High-Dose Sequential Chemoimmunotherapy and Autologous Stem-Cell Transplantation in Patients With Systemic B-Cell Lymphoma and Secondary CNS Involvement: Final Results of a Multicenter Phase II Trial.	26282634
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	HIV-negative patients with aggressive B-cell lymphoma and secondary CNS involvement at diagnosis or relapse, age 18 to 70 years, and Eastern Cooperative Oncology Group performance status <= 3 were enrolled and treated with high-doses of methotrexate and cytarabine, followed by R-HDS (cyclophosphamide, cytarabine, and etoposide) supported by autologous stem-cell transplantation (ASCT).	26282634
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Clofarabine salvage therapy before allogeneic hematopoietic stem cell transplantation in patients with relapsed or refractory AML: results of the BRIDGE trial.	26283567
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In patients with relapsed or refractory (r/r) acute myeloid leukemia (AML), long-term disease control can only be achieved by allogeneic hematopoietic stem cell transplantation (HSCT).	26283567
leukemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	HLA haploidentical peripheral blood stem cell transplantation using reduced dose of posttransplantation cyclophosphamide for poor-prognosis or refractory leukemia and myelodysplastic syndrome.	26284307
Colorectal Carcinoma, Neoplasms	Stem Cell Exhaustion	We enriched CD133+ colorectal cancer cells which manifested the CSCs-like properties such as higher levels of other stem cell markers Oct-4 and Sox-2, tumor sphere forming ability and more tumorigenic in NOD/SCID mice.	26284927
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells (CSCs) can invade and metastasize by epithelial-to-mesenchymal transition (EMT).	26284927
Neoplasms	Stem Cell Exhaustion	Prognostic genes were expressed in distinct tumor cell subpopulations, and genes implicated in proliferation and stem cells portended poor outcomes, while genes involved in normal lung differentiation and immune infiltration were associated with superior survival.	26286589
melanoma, Specialty Type - cancer	Stem Cell Exhaustion	Expression and prognostic value of putative cancer stem cell markers CD117 and CD15 in choroidal and ciliary body melanoma.	26290260
Specialty Type - cancer, Stage I Choroidal and Ciliary Body Melanoma AJCC v8	Stem Cell Exhaustion	The aim of the present study was to immunohistochemically investigate the expression and prognostic significance of putative cancer stem cell markers CD117 (c-kit), CD34, CD20 and CD15 in a cohort of patients with primary choroidal and ciliary body melanoma.	26290260
Proximity	Stem Cell Exhaustion	BM resident mesenchymal stem cells (BM-MSCs) are altered in MM and in vitro studies indicate their transformation by MM proximity is within hours.	26293751
Multiple Myeloma	Stem Cell Exhaustion	Stem cell mobilization chemotherapy with gemcitabine is effective and safe in myeloma patients with bortezomib-induced neurotoxicity.	26294015
Degenerative polyarthritis	Stem Cell Exhaustion	Plasma-Derived Fibronectin Stimulates Chondrogenic Differentiation of Human Subchondral Cortico-Spongious Progenitor Cells in Late-Stage Osteoarthritis.	26295224
Structure of articular cartilage	Stem Cell Exhaustion	Migration and chondrogenesis of human subchondral cortico-spongious progenitor cells (SPCs) are the key steps in the repair of microfracture-induced articular cartilage defects.	26295224
Fibrosis Assessment, Reperfusion Injury, Ischemia of kidney	Stem Cell Exhaustion	Amniotic Fluid Derived Stem Cells with a Renal Progenitor Phenotype Inhibit Interstitial Fibrosis in Renal Ischemia and Reperfusion Injury in Rats.	26295710
Kidney Diseases	Stem Cell Exhaustion	Mesenchymal stem cells derived from human amniotic fluid (hAFSCs) are a promising source for cellular therapy, especially for renal disorders, as a subpopulation is derived from the fetal urinary tract.	26295710
Interstitial Fibrosis Assessment	Stem Cell Exhaustion	hAFSCs contain a renal progenitor cell subpopulation that has a nephroprotective effect when delivered intra-arterially in rats with renal I/R injury, and reduces interstitial fibrosis on long term follow-up.	26295710
Brain Injuries	Stem Cell Exhaustion	The transcription factor Pax6 is a well-accepted neurogenic determinant during development, in adult neural progenitor cells and in acute brain injury models.	26295830
Breast Carcinoma, Childhood Breast Carcinoma	Stem Cell Exhaustion	Our purpose was to analyze the expression of FOXA2 in breast cancer cells, to explore its role in breast cancer stem cells, and to correlate its mRNA expression with clinicopathological features and outcome in a series of patients diagnosed with breast carcinoma.	26298189
Specialty Type - cancer	Stem Cell Exhaustion	We also knocked down FOXA2 mRNA expression by siRNA to determine the impact on cell proliferation and mammospheres formation using a cancer stem cells culture assay.	26298189
Specialty Type - cancer	Stem Cell Exhaustion	Our results suggest that FOXA2 promotes cell proliferation, maintains cancer stem cells, favors the development of Triple-Negative/Basal-like tumors, and is associated with increase relapses.	26298189
Specialty Type - cancer, Aggressive behavior, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Recently, there are several studies about cancer stem cells (CSC), indicating that they are the cells that initiate the tumor, provide progression, metastasis and responsible for the aggressive tumor behavior.	26298632
Kidney Failure, Acute, Injury of kidney	Stem Cell Exhaustion	Acute kidney injury (AKI) following stem-cell transplantation (SCT) contributes to a poor prognosis, yet its impact may vary depending on the timing of AKI onset.	26301965
Kidney Failure, Acute	Stem Cell Exhaustion	AKI prior to stem-cell engraftment was defined as early AKI and subsequently occurring AKI as late AKI.	26301965
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Numerical impairment of nestin(+) bone marrow niches in acute GvHD after allogeneic hematopoietic stem cell transplantation for AML.	26301968
Graft-vs-Host Disease, Acute GVH disease, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	To investigate whether acute GvHD (aGvHD) reduces the number of N(+)SCN, we examined patients with AML who had undergone allogeneic hematopoietic stem cell transplantation.	26301968
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	In patients with multiple myeloma (MM) undergoing autologous hematopoietic cell transplantation (auto-HCT), peripheral blood progenitor cells may be collected following mobilization with growth factor alone (GF) or cytotoxic chemotherapy plus GF (CC+GF).	26301967
Prostate carcinoma, Secondary Neoplasm	Stem Cell Exhaustion	Pristimerin Inhibits Prostate Cancer Bone Metastasis by Targeting PC-3 Stem Cell Characteristics and VEGF-Induced Vasculogenesis of BM-EPCs.	26302893
Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	The effect of Pristimerin on PC-3 stem cell characteristics and metastasis were detected by spheroid formation, CD133 and CD44 protein expression, matrix-gel invasive assay and colony-formation assay in vitro, VEGF and pro-inflammatory cytokines expression by ELISA assay, and tumor tumorigenicity by X-ray and MR in NOD-SCID mice model in vivo.	26302893
Secondary malignant neoplasm of prostate	Stem Cell Exhaustion	These data provide evidence that Pristimerin has strong potential for development as a novel agent against prostate bone metastasis by suppressing PC-3 stem cell characteristics and VEGF-induced vasculogenesis of BM-EPCs.	26302893
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem-like cells are shown to be highly tumorigenic, pro-angiogenic and can significantly contribute to tumor new vessel formation and bone marrow derived-EPCs (BM-EPCs) are shown to recruit to the angiogenic switch in tumor growth and metastatic progression, suggesting the importance of targeting cancer stem cells (CSCs) and EPCs for novel tumor therapies.	26302893
Graft-vs-Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	We investigated the tear cytokine profiles in patients who underwent stem cell transplantation (SCT) and attempted to evaluate whether tear cytokines are associated with the presence of systemic chronic graft-versus-host disease (GVHD), regardless of ocular GVHD status.	26303101
Lymphoma	Stem Cell Exhaustion	Plerixafor (Mozobil): A Stem Cell-Mobilizing Agent for Transplantation in Lymphoma Patients Predicted to Be Poor Mobilizers - A Pilot Study.	26303343
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation is the standard therapy for refractory/relapsed aggressive lymphoma.	26303343
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	We initiated a study to assess the use of plerixafor as a first-line stem cell mobilizer in 20 elderly or heavily pretreated patients with non-Hodgkin or Hodgkin lymphoma.	26303343
Atrial Fibrillation by ECG Finding	Stem Cell Exhaustion	Electromechanical mapping of the left ventricle for stem cell injection in a patient with permanent atrial fibrillation.	26304029
Usual Severity Pain, Ulcer	Stem Cell Exhaustion	This study was conducted to determine if intramuscular and intra-arterial stem cell injections delay or prevent major limb amputations, improve ankle-brachial index measurements, relieve rest pain, and improve ulcer healing.	26304481
Specialty Type - cancer	Stem Cell Exhaustion	Aldehyde dehydrogenase 1 (ALDH1) is a recognized cancer stem cell marker but little is known about its role in intratumoral stroma.	26305673
Liver carcinoma, Hollings Cancer Center, Hepatitis, Chronic	Stem Cell Exhaustion	Successful Interferon Therapy Reverses Enhanced Hepatic Progenitor Cell Activation in Patients with Chronic Hepatitis C. The enhanced accumulation of hepatic progenitor cells (HPCs) is related to the risk of progression to hepatocellular carcinoma (HCC).	26308703
Huntington disease-like syndrome due to C9ORF72 expansions	Stem Cell Exhaustion	Moreover, we identified a substantial defect in RNA export resulting in retention of RNA in the nuclei of Drosophila cells expressing expanded G4C2 repeats and also in mammalian cells, including aged induced pluripotent stem-cell-derived neurons from patients with C9orf72-related disease.	26308899
Diabetes	Stem Cell Exhaustion	To evaluate the acute effect of aerobic exercise (AE) and resistance exercise (RE) on the release of endothelial progenitor cell (EPCs, CD34+/KDR+/CD45 dim) and vascular function in type 1 diabetes (T1DM).	26312614
Diabetes Mellitus, Insulin-Dependent	Stem Cell Exhaustion	Exercise on Progenitor Cells in Healthy Subjects and Patients with Type 1 Diabetes.	26312614
X-linked inheritance, Immunologic Deficiency Syndromes	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) outcomes in X-linked severe combined immune deficiency are most effective when performed with patients <3 months of age and without coexisting morbidity, and with donor cells from a matched sibling.	26314823
Specialty Type - cancer	Stem Cell Exhaustion	The purpose of this study was to evaluate the effect of ABCG2 monoclonal antibody (McAb) combined with paclitaxel (PTX) conjugated with Fe3O4 nanoparticles (NPs) on MM progressed from cancer stem cells (CSCs) in non-obese-diabetic/severe-combined-immunodeficiency (NOD/SCID) mouse model.	26314844
Alzheimers Disease	Stem Cell Exhaustion	Therapeutic Effects of Transplantation of As-MiR-937-Expressing Mesenchymal Stem Cells in Murine Model of Alzheimer's Disease.	26316079
Up	Stem Cell Exhaustion	A therapeutic effect of transplantation of mesenchymal stem cells (MSCs) into murine model of AD has been reported, but remains to be further improved.	26316079
Liver carcinoma, Hollings Cancer Center	Stem Cell Exhaustion	Sal-like protein 4 (SALL4), a stem cell marker, has been identified as a potential target for aggressive hepatocellular carcinoma (HCC).	26317546
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	It has been considered that the detection methods for circulating tumor cells (CTCs) based on epithelial cell adhesion molecule (EpCAM) underestimate the number of CTCs and may miss a metastatic subpopulation with cancer stem cell (CSC) properties.	26317979
Osteoarthritis, Knee	Stem Cell Exhaustion	Assessment of clinical and MRI outcomes after mesenchymal stem cell implantation in patients with knee osteoarthritis: a prospective study.	26318655
Degenerative polyarthritis	Stem Cell Exhaustion	Cartilage regenerative procedures using the cell-based tissue engineering approach involving mesenchymal stem cells (MSCs) have been receiving increased interest because of their potential for altering the progression of osteoarthritis (OA) by repairing cartilage lesions.	26318655
BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 20	Stem Cell Exhaustion	This study aimed to investigate the relationship between circulating endothelial progenitor cell count and endothelial activation in a pediatric population with obesity.	26321689
Nausea, Blurred vision, Acute lymphocytic leukemia	Stem Cell Exhaustion	A 27-year-old woman with acute lymphocytic leukemia, who underwent allogeneic hematopoietic stem cell transplantation, complained of nausea and blurred vision 288 days after the transplantation.	26321719
Ischemia, Peripheral Arterial Diseases	Stem Cell Exhaustion	The extent and clinical significance of stem and progenitor cell (SPC) increases in response to lower-extremity ischemia in people with peripheral artery disease (PAD) are unclear.	26324152
Peripheral Arterial Diseases	Stem Cell Exhaustion	Ischemia-related changes in circulating stem and progenitor cells and associated clinical characteristics in peripheral artery disease.	26324152
B-Cell Lymphomas	Stem Cell Exhaustion	Induction chemotherapy followed by up-front autologous stem cell transplantation may have a survival benefit in high-risk diffuse large B-cell lymphoma patients.	26325332
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	We compared the outcomes of patients with higher-risk diffuse large B-cell lymphoma (DLBCL) who were treated with either up-front autologous stem cell transplantation (ASCT) or salvage chemotherapy followed by delayed ASCT after relapse.	26325332
Relapsing course	Stem Cell Exhaustion	CD34-Selected Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Relapsed, High-Risk Multiple Myeloma.	26325439
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We report results of a retrospective analysis of 44 patients with relapsed and high-risk multiple myeloma (MM) undergoing allogeneic CD34-selected hematopoietic stem cell transplantation (HSCT) from HLA-compatible donors.	26325439
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) after high-dose melphalan conditioning is considered a standard of care procedure for patients with multiple myeloma (MM).	26327631
Irritable Bowel Syndrome, Abnormality of red blood cells	Stem Cell Exhaustion	Reduction in duodenal endocrine cells in irritable bowel syndrome is associated with stem cell abnormalities.	26327765
Irritable Bowel Syndrome	Stem Cell Exhaustion	To determine whether the decreased density of duodenal endocrine cells in irritable bowel syndrome (IBS) is associated with abnormalities in stem cell differentiation.	26327765
Adenoma, Acidophil Stem Cell Pituitary Gland Adenoma, Neoplasms	Stem Cell Exhaustion	Pathological examinations revealed an atypical, monomorphous plurihormonal Pit-1 lineage tumor with mixed features of silent subtype 3 adenoma and acidophil stem cell adenoma.	26330191
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplant-anticipated multiple myeloma or lymphoma patients were eligible.	26331348
Peripheral Stem Cell Transplantation	Stem Cell Exhaustion	The median age was 62.3 years; patients had a median of three prior lines of therapy (range 1-4), with over 70% of the patients having received prior lenalidomide, bortezomib, and/or peripheral blood stem cell transplant.	26331432
Acute myocardial infarction, Venous Stroke	Stem Cell Exhaustion	Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction.	26332322
Pancreatic carcinoma, Secondary Neoplasm	Stem Cell Exhaustion	Nestin, a progenitor/stem cell marker, is expressed in human pancreatic cancer, where its expression correlates positively with invasiveness and metastasis.	26335012
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Overall, the T-cell receptor b chain repertoire in chronic lymphocytic leukemia is likely shaped by antigen selection and the implicated antigenic elements may concern epitopes that also select the malignant B-cell progenitors or, more intriguingly, chronic lymphocytic leukemia-derived epitopes.	26338994
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Expression of SOX-2 and Oct4 as markers for the identification of cancer stem cells (CSCs) has been revealed in several malignancies.	26339387
Thrombotic Microangiopathies, Unknown (origin) (qualifier value), Infection, Malignant Hypertension, Pathology, Autoimmune Diseases, Purpura, Thrombotic Thrombocytopenic, Hemorrhagic diarrhea	Stem Cell Exhaustion	Thrombocytopenic thrombotic purpura (TTP) is a thrombotic microangiopathy associated with hematopoietic stem cells transplantation, pregnancy, puerperium, drugs, bloody diarrhea, a heterogeneous group of illnesses, such as malignant hypertension, autoimmune and neoplastic diseases, infections, and an idiopathic group that includes the pathologies that don't apply for the preceding clinical categories.	26339877
Hematologic Neoplasms	Stem Cell Exhaustion	It has recently been shown that a T cell-replete allogeneic (allo) hematopoietic stem cell transplantation (HSCT) from a haploidentical donor (haplo-ID) could be a valid treatment for hematological malignancies.	26341397
Inflammation	Stem Cell Exhaustion	Adipose-derived stem cell (ADSC) transplantation is expected to be a minimally invasive, but effective, treatment for postoperative enterocutaneous fistulas associated with poor blood flow and chronic inflammation.	26342817
Communicable Diseases	Stem Cell Exhaustion	Bacterial infection remains a frequent complication in patients receiving a hematopoietic stem cell transplantation (HSCT).	26343154
leukemia	Stem Cell Exhaustion	We assessed functional consequences of modest reductions in PU.1 expression on leukemia development in mice harboring DNA lesions resembling those acquired during human stem cell aging.	26343801
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Heterozygous deletion of an enhancer of PU.1, which resulted in a 35% reduction of PU.1 expression, was sufficient to induce myeloid-biased preleukemic stem cells and their subsequent transformation to AML in a DNA mismatch repair-deficient background.	26343801
Disease, Specialty Type - cancer, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This study demonstrates that minimal reduction of a key lineage-specific transcription factor, which commonly occurs in human disease, is sufficient to initiate cancer development, and it provides mechanistic insight into the formation and progression of preleukemic stem cells in AML.	26343801
Leukemia, Myelomonocytic, Chronic	Stem Cell Exhaustion	Treatment with Hypomethylating Agents before Allogeneic Stem Cell Transplant Improves Progression-Free Survival for Patients with Chronic Myelomonocytic Leukemia.	26343946
Leukemia, Myelomonocytic, Chronic, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We retrospectively reviewed the data for 83 consecutive patients with CMML (47 with CMML-1/2 and 36 with CMML progressed to acute myeloid leukemia) who received an allogeneic stem cell transplant (allo-SCT) at our institution between April 1991 and December 2013 to identify factors associated with improved survival and determine whether treatment with hypomethylating agents before transplant improves progression-free survival (PFS).	26343946
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Results were compared to a historical control group of sibling donors who received filgrastim for stem cell mobilization for allogeneic stem cell transplantations in patients with AML and MDS.	26343949
Fatigue, Graft-vs-Host Disease, Infection	Stem Cell Exhaustion	Allogeneic stem cell transplantation (allo-HCT) is associated with high treatment-related mortality and innumerable physical and psychosocial complications and side-effects, such as high fatigue levels, loss of physical performance, infections, graft-versus-host disease (GvHD) and distress.	26345187
Viremia	Stem Cell Exhaustion	Risk factors and outcomes of cytomegalovirus viremia in pediatric hematopoietic stem cell transplantation patients.	26346369
Cytomegalovirus Infections, Persistent CMV viremia	Stem Cell Exhaustion	We investigated the incidence, time of onset, risk factors for CMV viremia, and characteristics of CMV diseases in 57 pediatric patients receiving hematopoietic stem cell transplantation (HSCT).	26346369
Mantle cell lymphoma	Stem Cell Exhaustion	Maintenance rituximab after autologous stem cell transplantation in patients with mantle cell lymphoma.	26347113
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	High-dose therapy and autologous stem cell transplantation (ASCT) improves outcomes for patients with mantle cell lymphoma (MCL), but relapse ultimately occurs in most patients.	26347113
Mantle cell lymphoma	Stem Cell Exhaustion	Pretransplantation Minimal Residual Disease Predicts Survival in Patients with Mantle Cell Lymphoma Undergoing Autologous Stem Cell Transplantation in Complete Remission.	26348890
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) is standard therapy for mantle cell lymphoma (MCL) in remission after induction chemotherapy, with the best results for patients in complete remission (CR).	26348890
Abdominal Pain, Multiple Myeloma, Hemorrhagic diarrhea	Stem Cell Exhaustion	We describe the case of a 54-year-old woman with relapse of multiple myeloma 3 years after myeloablative allogeneic stem cell transplant who developed abdominal pain and bloody diarrhea following 7 months of lenalidomide therapy.	26350196
Neoplasms, Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	CD90(+) cells in and around blood vessels in cancers including brain tumors have been identified as endothelial cells, cancer stem cells, fibroblasts or pericytes.	26350700
Acute lymphocytic leukemia	Stem Cell Exhaustion	Philadelphia chromosome positive acute lymphoblastic leukemia is classified as a very high-risk group and it requires an intensive chemotherapy regimen associated with tyrosine-kinase inhibitors and allogeneic hematopoietic stem cell transplant from related or unrelated HLA matched donor.	26351543
Degenerative polyarthritis	Stem Cell Exhaustion	Altered Expression of Wnt Signaling Pathway Components in Osteogenesis of Mesenchymal Stem Cells in Osteoarthritis Patients.	26352263
Degenerative polyarthritis	Stem Cell Exhaustion	Osteoarthritis (OA) is characterized by altered homeostasis of joint cartilage and bone, whose functional properties rely on chondrocytes and osteoblasts, belonging to mesenchymal stem cells (MSCs).	26352263
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The purpose of this study was to determine the correlations between inflammatory factors-including absolute lymphocyte count, lactate dehydrogenase, b2-microglobulin, albumin, C-reactive protein, and ferritin-and the prognosis for survival in patients with multiple myeloma (MM) treated with induction chemotherapy containing thalidomide and who underwent autologous stem cell transplantation (ASCT).	26354062
CLTC gene, Hemorrhagic cystitis, Communicable Diseases	Stem Cell Exhaustion	Hemorrhagic cystitis (HC) is a common complication after hematopoietic allogeneic stem cell transplantation (HSCT) associated with intensity of the conditioning regimen, cyclophosphamide (Cy) therapy, and BK polyomavirus (BKPyV) infection.	26354178
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Efficacy of stem cell in improvement of left ventricular function in acute myocardial infarction--MI3 Trial.	26354213
Specialty Type - cancer	Stem Cell Exhaustion	The sphere-forming hepatocytes expressed a number of cancer stem-like cell (CSC) markers, including high levels of the stem cell factor receptor c-Kit.	26355082
Alveolar rhabdomyosarcoma	Stem Cell Exhaustion	The presence of PAX3-FOXO1 in SNS and alveolar rhabdomyosarcoma suggests that these two entities are genetically similar lesions arising from distinct progenitor cell pools.	26355893
Pulmonary Complication	Stem Cell Exhaustion	A retrospective analysis of computed tomography findings in patients with pulmonary complications after allogeneic hematopoietic stem cell transplantation.	26358372
Pulmonary Complication	Stem Cell Exhaustion	The purpose of this study was to review the high-resolution computed tomography (CT) findings in patients with pulmonary complications after allogeneic hematopoietic stem cell transplantation (HSCT), and to evaluate the relationship between CT findings and clinical outcomes.	26358372
Arterial Stiffness, Lupus Erythematosus, Metabolic Syndrome X	Stem Cell Exhaustion	Metabolic syndrome is associated with decreased circulating endothelial progenitor cells and increased arterial stiffness in systemic lupus erythematosus.	26359174
Arterial Stiffness, Atherosclerosis, ETV3 gene	Stem Cell Exhaustion	We examined the contribution of MetS to inflammatory markers, arterial stiffness and circulating endothelial progenitor cells (EPCs) as surrogates of subclinical atherosclerosis.	26359174
Sample Size Calculation	Stem Cell Exhaustion	NRP1 expression was assessed in SSc and healthy dermal microvascular endothelial cells (SSc-MVECs and H-MVECs), and in SSc and control endothelial progenitor cell (EPC)-derived endothelial cells (ECs).	26359450
Weight decreased, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Pre-transplant weight loss predicts inferior outcome after allogeneic stem cell transplantation in patients with myelodysplastic syndrome.	26360778
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic stem cell transplantation (alloSCT) represents a curative therapeutic option for patients with myelodysplastic syndrome (MDS), but relapse and non-relapse mortality (NRM) limit treatment efficacy.	26360778
Multiple Myeloma	Stem Cell Exhaustion	We compared outcomes between high-risk and standard-risk myeloma patients who underwent autologous hematopoietic stem-cell transplantation (auto-HCT) at our institution between January 2005 and December 2009.	26361647
Fanconi Anemia	Stem Cell Exhaustion	A Successful Second Stem Cell Transplantation in Fanconi Anemia: A Case Report.	26361704
Fanconi Anemia	Stem Cell Exhaustion	The aim was to describe a case of successful second stem cell transplantation in Fanconi anemia (FA).	26361704
Disturbance	Stem Cell Exhaustion	Since endothelial progenitor cells (CD34-positive cells) have been reported to contribute to vascular repair, our results indicate that in non-hypertensive subjects, triglycerides may stimulate an increase in circulating CD34-positive cells (vascular repair) by inducing vascular disturbance.	26363435
Failure, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Disease relapse is the major causes of treatment failure after allogeneic stem cell transplantation (SCT) in patients with acute myeloid leukemia (AML).	26363443
Superficial abrasion, Hydrarthrosis	Stem Cell Exhaustion	Abrasion arthroplasty increases mesenchymal stem cell content of postoperative joint effusions.	26364138
Specialty Type - cancer	Stem Cell Exhaustion	CD44, SOX2 and SHH have been implicated in resistance to CRT, possibly through an association with a cancer stem cell phenotype.	26364884
Neoplasms	Stem Cell Exhaustion	Survival of patients who develop solid tumors following hematopoietic stem cell transplantation.	26367222
Respiratory Tract Infections	Stem Cell Exhaustion	Mortality in hematopoietic stem cell transplant recipients with lower respiratory tract RSV infection can exceed 80%.	26367224
Histocompatibility	Stem Cell Exhaustion	UGT2B17 minor histocompatibility mismatch and clinical outcome after HLA-identical sibling donor stem cell transplantation.	26367234
Graft-vs-Host Disease	Stem Cell Exhaustion	Minor histocompatibility Ags (mHags) have been implicated in the pathogenesis of GVHD after allogeneic hematopoietic stem cell transplantation (HSCT).	26367234
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Salvage chemotherapy followed by autologous stem cell transplantation (ASCT) is the standard second-line treatment for relapsed and refractory diffuse large B-cell lymphoma (DLBCL).	26367239
Asthma, Fibrosis Assessment	Stem Cell Exhaustion	Fibrocytes are bone marrow-derived circulating progenitor cells that have been implicated in tissue fibrosis and T(H)2 responses in asthmatic patients.	26371837
Leukemia, Myelomonocytic, Chronic, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Azacitidine is a demethylating and cytotoxic drug for the treatment of adult patients with (1) myelodysplastic syndromes, (2) chronic myelomonocytic leukemia, and (3) acute myeloid leukemia who are not eligible for induction treatment or hematopoietic stem cell transplantation.	26371947
Nystagmus, Farber Lipogranulomatosis	Stem Cell Exhaustion	A 30 months-old boy with Farber disease developed nystagmus 12 months after hematopoietic stem cell transplantation (HSCT).	26373951
Burn injury	Stem Cell Exhaustion	Chemical burns remain the main cause of limbal stem cell deficiency.	26375332
Hematologic Neoplasms	Stem Cell Exhaustion	However, there is no standard protocol indicating the use of HEPA filters for patients with hematological malignancies, except for those who have undergone allogeneic hematopoietic stem cell transplantation.	26376622
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disease.	26376664
Autoimmune hemolytic anemia	Stem Cell Exhaustion	Eligible patients had a WHO performance status of 0-2, had a response assessment within the previous 3 months, did not have refractory disease, autoimmune haemolytic anaemia requiring treatment, chronic or active infection requiring treatment, and had not previously received maintenance treatment or autologous or allogeneic stem-cell transplant.	26377300
Lymphoma, Non-Hodgkin, Familial, Hodgkin Disease, Lymphoma, Non-Hodgkin, LIPC gene	Stem Cell Exhaustion	High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (AHCT) is a well-defined treatment modality for relapsed/refractory non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL).	26377357
Autoimmune Diseases	Stem Cell Exhaustion	Allogeneic and xenogeneic transplantation are suitable alternatives for treating patients with stem cell defects and autoimmune diseases.	26377835
Lupus Erythematosus	Stem Cell Exhaustion	Comparative Efficacies of Long-Term Serial Transplantation of Syngeneic, Allogeneic, Xenogeneic, or CTLA4Ig-Overproducing Xenogeneic Adipose Tissue-Derived Mesenchymal Stem Cells on Murine Systemic Lupus Erythematosus.	26377835
Lupus Erythematosus, Encephalitis, St. Louis	Stem Cell Exhaustion	The purpose of this study was to compare the effects of long-term serial transplantation of adipose tissue-derived mesenchymal stem cells (ASCs) from (NZB x NZW) F1 mice (syngeneic), BALB/c mice (allogeneic), or humans (xenogeneic) on systemic lupus erythematosus (SLE).	26377835
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	This case illustrates an association between atypical chronic myeloid leukemia and steroid-responsive paraneoplastic vasculitis and highlights the single-agent disease activity of decitabine in atypical chronic myeloid leukemia, which may be utilized as a bridging therapy to allogeneic stem cell transplantation.	26378157
Autoimmune Diseases	Stem Cell Exhaustion	For patients with severe and refractory autoimmune diseases, high-dose chemotherapy and autologous hematopoietic stem cell transplantation has been established as a considerable therapeutic option in recent years.	26381040
Autoimmune Diseases	Stem Cell Exhaustion	Low-dose cyclophosphamide effectively mobilizes peripheral blood stem cells in patients with autoimmune disease.	26381040
Autoimmune Diseases	Stem Cell Exhaustion	In this retrospective single-center analysis, we assessed the feasibility and efficacy of peripheral blood stem cells (PBSC) mobilization and collection in 35 patients with refractory autoimmune disease (AID).	26381040
Doxorubicin/Methotrexate/Vinblastine, Arteriovenous Malformations, Cerebral	Stem Cell Exhaustion	Our report illustrates a unique case of de novo development of a cerebral arteriovenous malformation (AVM) after implantation of genetically modified allogeneic mesenchymal stem cells in the brain.	26382859
Doxorubicin/Methotrexate/Vinblastine	Stem Cell Exhaustion	The development of an AVM within a period of 3 years after implantation of the glucagon-like peptide-1-secreting mesenchymal stem cells suggests a possible relationship.	26382859
Keratoconjunctivitis	Stem Cell Exhaustion	Stem Cell Factor and Thymic Stromal Lymphopoietin Overexpression With Correlation to Mast Cells in Superior Limbic Keratoconjunctivitis.	26382891
Keratoconjunctivitis, Stem Cell Factor	Stem Cell Exhaustion	To investigate the differential expression of stem cell factor (SCF) and thymic stromal lymphopoietin (TSLP) and their correlation to mast cells, between patients diagnosed with superior limbic keratoconjunctivitis (SLK) and normal subjects.	26382891
Bronchiolitis Obliterans, Allogeneic Hematopoietic Stem Cell Transplantation	Stem Cell Exhaustion	Prognostic role of FEV1 for survival in bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation.	26383085
Bronchiolitis Obliterans, Bosnian language	Stem Cell Exhaustion	Bronchiolitis obliterans syndrome (BOS) can occur after hematopoietic stem cell transplantation (HSCT) and is associated with significant mortality.	26383085
Colorectal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	A new insight into cancer stem cell markers: Could local and circulating cancer stem cell markers correlate in colorectal cancer?	26383518
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cell (CSC) markers could serve as potential prognostic procedure.	26383518
Malignant Peripheral Nerve Sheath Tumor	Stem Cell Exhaustion	This association might be explained by the chronic inflammatory state and oxidative stress in response to smoking, eliciting genomic instability in the stem cell compartment and ultimately clonal evolution resulting in MPNs.	26384085
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Steroid-refractory acute graft-versus-host disease (aGVHD) remains an important cause of morbidity and mortality after allogeneic stem cell transplantation (SCT).	26386320
Stomach Carcinoma	Stem Cell Exhaustion	Prognostic significance of leucine-rich-repeat-containing G-protein-coupled receptor 5, an intestinal stem cell marker, in gastric carcinomas.	26386561
Malignant tumor of colon, Specialty Type - cancer	Stem Cell Exhaustion	Cells expressing LGR5, an intestinal stem cell marker, have been suggested as cancer stem cells in human colon cancers.	26386561
Gastric Adenoma	Stem Cell Exhaustion	In addition, most gastric adenomas contain abundant LGR5-expressing cells coexpressing intestinal stem cell signatures.	26386561
Specialty Type - cancer, Malignant neoplasm of skin	Stem Cell Exhaustion	Comparative expression analysis of putative cancer stem cell markers CD44 and ALDH1A1 in various skin cancer subtypes.	26391478
Specialty Type - cancer, melanoma, Neoplasms, Malignant neoplasm of skin	Stem Cell Exhaustion	Skin cancers, particularly melanoma, are initiated and maintained by a subpopulation of tumor cells expressing stemness markers that are called cancer stem cells (CSCs).	26391478
Diabetes Mellitus	Stem Cell Exhaustion	For the patients who received rituximab-containing chemotherapy, the risk factors included female gender, diabetes mellitus, multiple courses of chemotherapy, autologous hematopoietic stem cell transplantation and higher accumulated rituximab dose.	26391893
Neutrophilic dermatosis, MYELODYSPLASTIC SYNDROME, Myeloproliferation, Leukemia, Myelomonocytic, Chronic, Polyarthritis, Vasculitis, CTCAE, Autoimmune Diseases	Stem Cell Exhaustion	Chronic myelomonocytic leukemia (CMML), a clonal hematopoietic stem cell disorder with myelodysplastic and myeloproliferative overlap feature, is frequently associated with autoimmune diseases, such as vasculitis, polyarthritis, and neutrophilic dermatosis.	26392142
Transplant-Related Malignant Neoplasm, Comorbidity	Stem Cell Exhaustion	Although the application of Hematopoietic Cell Transplantation-specific Comorbidity Index (HCT-CI) has enabled better prediction of transplant-related mortality (TRM) in allogeneic hematopoietic stem cell transplants (AHSCT), data from developing countries are scarce.	26394228
Amyotrophic Lateral Sclerosis	Stem Cell Exhaustion	We studied a new method of treatment of amyotrophic lateral sclerosis with autologous mesenchymal stem cells.	26395626
Acute leukemia	Stem Cell Exhaustion	Patients undergoing haematopoietic stem cell transplantation or chemotherapy for acute leukaemia were enrolled for biomarker screening.	26400571
Pancytopenia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 4-year-old girl with history of acute myeloid leukemia post chemotherapy and stem cell transplant presented with pancytopenia.	26402136
Bone necrosis	Stem Cell Exhaustion	Decreased Osteogenic Activity of Mesenchymal Stem Cells in Patients With Corticosteroid-Induced Osteonecrosis of the Femoral Head.	26404846
Stem cells	Stem Cell Exhaustion	Is the protein expression window during testicular development affected in patients at risk for stem cell loss?	26405262
Stem cells	Stem Cell Exhaustion	Is the protein expression window during testicular development affected in prepubertal patients at risk for stem cell loss?	26405262
Specialty Type - cancer	Stem Cell Exhaustion	A minority of cancer cells with characteristics of cancer stem cells (CSC) may be responsible for progression and development of chemotherapy resistance in this disease.	26406410
Immunocompromised Host	Stem Cell Exhaustion	Immunocompromised patients comprised 8 hematopoietic stem cell transplant recipients (group A) and 9 immunosuppressive therapy recipients (group B), and controls consisted of 14 children aged >1 year (group C) and 22 infants (group D).	26410591
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myelogenous leukaemia (CML) is a hematopoietic stem cell disease with a relatively stable clinical course.	26411119
Cholangiolocellular Carcinoma, Malignant neoplasm of liver	Stem Cell Exhaustion	Cholangiolocellular carcinoma (CoCC) is a rare type of malignant liver tumor derived from hepatic stem cells, which exist in the canals of Hering.	26414834
Malignant neoplasm of pancreas, Malignant neoplasm of gastrointestinal tract	Stem Cell Exhaustion	They also drive intestinal stem cell proliferation and positioning, control intestinal tissue boundaries and are involved in liver, pancreatic and colorectal cancers, indicating involvement in additional digestive system malignancies.	26414866
Infection of bloodstream	Stem Cell Exhaustion	High Incidence of Afebrile Bloodstream Infection Detected by Surveillance Blood Culture in Patients on Corticosteroid Therapy after Allogeneic Hematopoietic Stem Cell Transplantation.	26415560
Behavioral Symptoms Index Composite Score (BASC-2), Infection of bloodstream	Stem Cell Exhaustion	Bloodstream infections (BSI) are still important complications after allogeneic hematopoietic stem cell transplantation (allo-SCT).	26415560
Primary cutaneous lymphoma	Stem Cell Exhaustion	Allogeneic stem-cell transplantation in patients with cutaneous lymphoma: updated results from a single institution.	26416896
TSPYL2 gene	Stem Cell Exhaustion	In this article, we report the largest single-center experience with allogeneic stem-cell transplantation (SCT) for advanced CTCL.	26416896
Pregnancy	Stem Cell Exhaustion	Our findings indicate that stem cell deficiency and accelerated stromal senescence limit the differentiation capacity of the endometrium and predispose for pregnancy failure.	26418742
Cytogenetic Complete Response	Stem Cell Exhaustion	Our investigation demonstrated that CRC cells with silenced NDRG1 showed more tumorigenic ability and stem cell-like properties, such as: colony and sphere formation, chemoresistance, cell invasion, high expression of CD44, and tumorigenicity in vivo.	26418878
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease (aGvHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation.	26418955
Metabolic Bone Disorder, Osteoporosis	Stem Cell Exhaustion	Collectively, these results may point to the GCN5-NF-kB pathway as a novel potential molecular target for stem cell mediated regenerative medicine and the treatment of metabolic bone diseases such as osteoporosis.	26420353
Malignant Pleural Mesothelioma	Stem Cell Exhaustion	Expression of the Stem Cell Factor Nestin in Malignant Pleural Mesothelioma Is Associated with Poor Prognosis.	26421614
Hematologic Neoplasms	Stem Cell Exhaustion	Reconstitution of lymphocyte subpopulations after hematopoietic stem cell transplantation: comparison of hematologic malignancies and donor types in event-free patients.	26422556
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	CD25 expression on residual leukemic blasts at the time of allogeneic hematopoietic stem cell transplant predicts relapse in patients with acute myeloid leukemia without complete remission.	26422713
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Risk factors for outcome in refractory acute myeloid leukemia patients treated with a combination of fludarabine, cytarabine, and amsacrine followed by a reduced-intensity conditioning and allogeneic stem cell transplantation.	26424692
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HCT) is considered a standard treatment for high-risk acute myeloid leukemia (AML) in first or second complete remission (CR).	26424692
Fibrosis Assessment, Malignant Neoplasms, Pneumonia, Interstitial	Stem Cell Exhaustion	Moreover, 4 patients who had chemotherapy and hematopoietic stem cell transplantation due to hematologic malignancy showed unclassifiable interstitial pneumonia with extensive fibrosis in the lungs.	26425040
End Stage Liver Disease	Stem Cell Exhaustion	Reinfusion of highly purified CD133+ bone marrow-derived stem/progenitor cells in patients with end-stage liver disease: A phase I clinical trial.	26427587
Tissue injury	Stem Cell Exhaustion	Bone marrow stem/progenitor cells seem to be effective in liver regeneration after tissue injury.	26427587
End Stage Liver Disease	Stem Cell Exhaustion	To evaluate the feasibility and safety of the mobilization and reinfusion of CD133+ stem/progenitor cells in patients with end-stage liver disease.	26427587
End Stage Liver Disease	Stem Cell Exhaustion	16 subjects with Model for End-stage Liver Disease (MELD) score between 17 and 25 were enrolled, 14 mobilized an adequate number of CD133+ stem/progenitor cells and 12 were reinfused.	26427587
End Stage Liver Disease	Stem Cell Exhaustion	CD133+ stem/progenitor cells reinfusion in patients with end-stage liver disease is feasible and safe.	26427587
Multiple Myeloma	Stem Cell Exhaustion	To evaluate the feasibility of selecting a mobilization regimen based on the response to induction therapy, we retrospectively analyzed 179 multiple myeloma patients who underwent stem cell mobilization.	26428939
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Busulfan plus cyclophosphamide versus busulfan plus fludarabine as a preparative regimen for allogeneic haemopoietic stem-cell transplantation in patients with acute myeloid leukaemia: an open-label, multicentre, randomised, phase 3 trial.	26429297
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The standard busulfan-cyclophosphamide myeloablative conditioning regimen is associated with substantial non-relapse mortality in patients older than 40 years with acute myeloid leukaemia who are undergoing allogeneic stem-cell transplantation.	26429297
Mycoses	Stem Cell Exhaustion	Reduction in incidence of invasive fungal infection in patients receiving allogeneic stem cell transplantation using combined diagnostic-driven approach and itraconazole oral solution.	26429354
Mycoses	Stem Cell Exhaustion	Invasive fungal infections are an important cause of morbidity and mortality after allogeneic haematopoietic stem cell transplantation.	26429354
Neutropenia, Mycoses	Stem Cell Exhaustion	We evaluated, in our allogeneic stem cell transplant patients, the effect on the incidence of invasive fungal infection during neutropenia of a strategy combining a diagnostic-driven approach with chemoprophylaxis during higher risk periods of graft vs. host disease and prolonged neutropenia, using itraconazole oral solution with parenteral voriconazole bridging.	26429354
Breast Carcinoma, Specialty Type - cancer, Childhood Breast Carcinoma, Triple-Negative Breast Cancer Finding	Stem Cell Exhaustion	Here, we show that MCM2 is highly expressed in clinical samples of invasive carcinoma of the breast, especially triple-negative breast cancer (TNBC), and in cancer stem cell (CSC) marker-positive breast cancer cells.	26430873
Heterotopic Ossification, Hypoxia	Stem Cell Exhaustion	The impact of hypoxia on mesenchymal progenitor cells of human skeletal tissue in the pathogenesis of heterotopic ossification.	26432574
Healthcare Encounters Domain, Heterotopic Ossification	Stem Cell Exhaustion	Mesenchymal progenitor cells (MPCs) are capable of differentiating into osteo/chondrogenic cells to contribute substantially to heterotopic ossification (HO).	26432574
Graft-vs-Host Disease	Stem Cell Exhaustion	Genome-wide surveillance of mismatched alleles for graft-versus-host disease in stem cell transplantation.	26432889
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease (aGVHD) represents one of the major complications in allogeneic stem cell transplantation and is primarily caused by genetic disparity between the donor and recipient.	26432889
Malignant Neoplasms	Stem Cell Exhaustion	The characterisation of dividing brain cells is fundamental for studies ranging from developmental and stem cell biology, to brain cancers.	26432933
Polycythemia Vera, Erythrocytosis, Primary Myelofibrosis, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Polycythemia vera (PV) is a clonal stem cell disorder characterized by erythrocytosis and associated with burdensome symptoms, reduced quality of life, risk of thrombohemorrhagic complications, and risk of transformation to myelofibrosis and acute myeloid leukemia.	26433906
Graft-vs-Host Disease	Stem Cell Exhaustion	Subtle lesions of terminal hepatic venules (THVs) may be overlooked in liver biopsies from haematopoietic stem cell transplant (HSCT) receipients when graft-versus-host disease is the clinical concern.	26434389
Multiple Myeloma	Stem Cell Exhaustion	A randomized phase II study of stem cell mobilization with cyclophosphamide+G-CSF or G-CSF alone after lenalidomide-based induction in multiple myeloma.	26437056
Acute leukemia	Stem Cell Exhaustion	Limited therapeutic options are available after relapse of acute leukaemia following first reduced intensity conditioning haematopoietic stem cell transplantation (RIC1).	26437057
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Long-term results of adjuvant donor lymphocyte transfusion in AML after allogeneic stem cell transplantation.	26437060
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Adjuvant transfusion of donor lymphocytes (aDLT) may reduce the risk of relapse after allogeneic stem cell transplantation in high-risk AML.	26437060
Dysautonomia, Familial	Stem Cell Exhaustion	Familial Dysautonomia (FD) Human Embryonic Stem Cell Derived PNS Neurons Reveal that Synaptic Vesicular and Neuronal Transport Genes Are Directly or Indirectly Affected by IKBKAP Downregulation.	26437462
Dysautonomia, Familial	Stem Cell Exhaustion	Here we found new molecular insights for the IKAP role and the impact of the FD mutation in the human PNS lineage by using a novel and unique human embryonic stem cell (hESC) line homozygous to the FD mutation originated by pre implantation genetic diagnosis (PGD) analysis.	26437462
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Twenty-one (55%) patients had newly diagnosed AML, 14 (37%) had relapsed AML, and 3 (8%) underwent bridging therapy before allogeneic stem-cell transplantation.	26437871
Myeloproliferative disease	Stem Cell Exhaustion	Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms.	26438359
Neoplasms, Communicable Diseases	Stem Cell Exhaustion	NK cells play a major role in protection against tumor recurrence and infection after allogeneic hematopoietic stem cell transplantation (HSCT).	26438526
Aplastic Anemia	Stem Cell Exhaustion	Impairment of hematopoietic stem cell niches in patients with aplastic anemia.	26440975
Hematopoietic stem cells	Stem Cell Exhaustion	These data indicate that AA is associated with impaired hematopoietic stem cell niches.	26440975
Colorectal Carcinoma	Stem Cell Exhaustion	Clinical significance of stem cell marker CD133 expression in colorectal cancer.	26442717
Neoplasms	Stem Cell Exhaustion	CD133, a glycoprotein, is expressed in different types of human stem cells and tumor cells.	26442717
Growth	Stem Cell Exhaustion	Down-regulation of DCLK1 results in loss of cancer-stem-cells (CSCs), and inhibits spheroidal/xenograft growths from hCRC-cells.	26447334
Double-Hit Lymphoma	Stem Cell Exhaustion	Patients with MYC/BCL2 double-hit lymphoma (DHL) are known to have an aggressive clinical course and to respond poorly to various therapies including intensive chemotherapy and stem cell transplant.	26448193
Mucoepidermoid Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Here, we investigated the expression of putative cancer stem cell markers (ALDH, CD10, CD24, CD44) in primary human mucoepidermoid carcinomas by immunofluorescence, in vitro salisphere assays, and in vivo tumorigenicity assays in immunodeficient mice.	26449187
Specialty Type - cancer	Stem Cell Exhaustion	ALDH/CD44 identifies uniquely tumorigenic cancer stem cells in salivary gland mucoepidermoid carcinomas.	26449187
Neoplasms	Stem Cell Exhaustion	These unique cells, namedcancer stem cells, are considered drivers of tumor progression in these tumors.	26449187
Specialty Type - cancer	Stem Cell Exhaustion	The purpose of this work is to understand if cancer stem cells play a functional role in the tumorigenesis of salivary gland mucoepidermoid carcinomas.	26449187
Specialty Type - cancer	Stem Cell Exhaustion	Collectively, these data demonstrate that salivary gland mucoepidermoid carcinomas contain a small population of cancer stem cells with enhanced tumorigenic potential and that are characterized by high ALDH activity and CD44 expression.	26449187
Acute leukemia	Stem Cell Exhaustion	In patients with acute leukaemia and recipients of haematopoietic stem cell and solid organ transplants the predicted incidence is more than 55 every year.	26449504
Graft-vs-Host Disease	Stem Cell Exhaustion	Chronic graft-vs.-host disease (GVHD) is a severe and potentially fatal complication in patients after undergoing allogeneic stem cell transplant.	26449730
Hematologic Neoplasms	Stem Cell Exhaustion	We report four cases of patients seen at Stanford Hospital between January 2013 to December 2014 with hematologic malignancy who developed hyperkeratotic papules and plaques on the palms and soles after allogeneic hematopoietic stem cell transplant.	26449730
Hematologic Neoplasms	Stem Cell Exhaustion	Donor lymphocyte infusion (DLI) is used for treatment of hematologic malignancy relapse or mixed chimerism after allogeneic hematopoietic stem cell transplantation.	26449992
Communicable Diseases	Stem Cell Exhaustion	Allogeneic stem cell transplantation (allo-HSCT) provides a unique opportunity to track Epstein-Barr virus (EBV) infection in the context of the reconstituting B-cell system.	26450987
Best Case Imputation Technique, Bladder Carcinoma Infiltrating the Muscle of the Bladder Wall, Specialty Type - cancer	Stem Cell Exhaustion	Striking evidence associates cancer stem cells (CSCs) to the high recurrence rates and poor survival of patients with muscle-invasive bladder cancer (BC).	26452033
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	We report a 35-year-old female patient with cerebral manifestations of chronic graft-versus-host disease (cGvHD) and putative retinal involvement after allogeneic peripheral blood stem cell transplantation (alloHSCT).	26452109
Inflammation, Specialty Type - cancer, Congenital contractural arachnodactyly	Stem Cell Exhaustion	Surprisingly, let-7c/miR-99a/miR-125b cluster also significantly decreased the ability of CCA cells for cancer stem cell-like mammosphere generation by downregulating CD133 and CD44, which suggests the pivotal roles of let-7c, miR-99a and miR-125b in CCA by regulating both inflammation and stem-like properties.	26455324
Fecal Incontinence, Colonization, Communicable Diseases	Stem Cell Exhaustion	Our multivariate analysis identified factors associated with a significant risk for CRKP colonization or infection: solid organ or stem cell transplantation (OR, 5.05; 95% CI, 1.23-20.8; P=.03), mechanical ventilation (OR, 2.56; 95% CI, 1.24-5.28; P=.01), fecal incontinence (OR, 5.78; 95% CI, 1.52-22.0; P=.01), and exposure in the prior 30 days to meropenem (OR, 3.55; 95% CI, 1.04-12.1; P=.04), vancomycin (OR, 2.94; 95% CI, 1.18-7.32; P=.02), and metronidazole (OR, 4.22; 95% CI, 1.28-14.0; P=.02).	26455382
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	Autologous stem cell transplant (ASCT) can improve outcomes for mantle cell lymphoma (MCL) patients, yet relapses are frequent.	26455717
Pseudallescheria, Aspergillus fumigatus allergenic extract	Stem Cell Exhaustion	Pseudallescheria boydii with Aspergillus fumigatus and Aspergillus terreus in a Critically Ill Hematopoietic Stem Cell Recipient with ARDS.	26455910
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease is a major complication of allogeneic hematopoietic stem cell transplantation.	26456486
Specialty Type - cancer	Stem Cell Exhaustion	Clinical influence of cancer stem cells on residual disease after preoperative chemoradiotherapy for rectal cancer.	26456957
Specialty Type - cancer, Rectal Carcinoma	Stem Cell Exhaustion	We evaluated the clinical influence of cancer stem cells (CSCs) on residual disease after preoperative chemoradiotherapy (CRT) in patients with rectal cancer.	26456957
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	High-dose chemotherapy (HDT) with autologous stem cell transplantation is the standard of care for relapsed/refractory (RR) Hodgkin lymphoma (HL).	26458240
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	[The role of hematopoietic stem cell transplantation for acute myeloid leukemia].	26458433
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) plays an important role in treating younger patients with acute myeloid leukemia (AML).	26458433
Bone Marrow Lymphoplasmacytic Infiltrate, Hyperviscosity, Waldenstrom Macroglobulinemia	Stem Cell Exhaustion	Waldenstrom macroglobulinemia (WM) is a rare and incurable B-cell neoplasm characterized by lymphoplasmacytic bone marrow infiltration and the production of serum monoclonal immunoglobulin M. Therapeutic strategies for WM should be based on individual patient and disease characteristics, including age, suitability as a candidate for autologous stem cell transplantation, hyperviscosity, and comorbidities.	26458447
Specialty Type - cancer	Stem Cell Exhaustion	ALDH1 is a crucial element in the retinoic acid signaling pathway regulating the self-renewal and differentiation of normal stem cells, and may play an important role in cancer progression.	26462023
Inflammation, Ischemia	Stem Cell Exhaustion	Inflammation is associated with a reduced number of pro-angiogenic Tie-2 monocytes and endothelial progenitor cells in patients with critical limb ischemia.	26462497
Specialty Type - cancer	Stem Cell Exhaustion	In vitro assay demonstrated that CXCL10 stimulus increased the rate of CD133(+) cancer stem cells (CSCs) in HepG2 cells by binding to CXCR3 and then inducing c-Myc expression.	26462839
Multiple Myeloma	Stem Cell Exhaustion	Multiple myeloma is the most common indication for high-dose chemotherapy and autologous stem cell transplantation (ASCT), and lenalidomide maintenance after transplant is now standard.	26464015
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	A 59-year-old female received a matched related donor stem cell transplant for chronic myelogenous leukemia.	26464160
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Long-term outcome of patients with newly diagnosed chronic myeloid leukemia: a randomized comparison of stem cell transplantation with drug treatment.	26464170
Adenocarcinoma of lung (disorder), Specialty Type - cancer	Stem Cell Exhaustion	Epithelial-mesenchymal transition in patients of pulmonary adenocarcinoma: correlation with cancer stem cell markers and prognosis.	26464642
Malignant neoplasm of lung	Stem Cell Exhaustion	The existence of lung cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT) in human tissue is controversy.	26464642
Histiocytosis, Histiocytic Disorders, Malignant, Histiocytosis, Langerhans-Cell	Stem Cell Exhaustion	The coexistence of LCH and ECD in the same biopsy and the BRAF (V600E) mutation status in both histologic types support the recent re-classification of the histiocytic disorder into LCH, ECD, and "mixed histiocytosis", which reflects tumorigenesis for all three from a common progenitor cell.	26466952
Childhood Breast Carcinoma	Stem Cell Exhaustion	Differential expression of epithelial-mesenchymal transition and stem cell markers in intrinsic subtypes of breast cancer.	26467042
Childhood Breast Carcinoma	Stem Cell Exhaustion	This information is important in understanding the biology of triple negative breast cancer, also in terms of future studies dealing with targeted therapies based on the alterations of EMT and stem cell markers.	26467042
Cardiovascular Diseases	Stem Cell Exhaustion	It has been proposed that vascular progenitor cells play an important role in vascular repair, but their possible clinical importance in cardiovascular disease has not been fully characterized.	26467529
Stem Cell Factor	Stem Cell Exhaustion	To our knowledge, this is the first clinical study to provide evidence to support a key role for SCF and progenitor cells in vascular repair.	26467529
Myeloproliferative disease	Stem Cell Exhaustion	Myeloproliferative neoplasms (MPN) are chronic myeloid cancers thought to arise at the level of CD34+ hematopoietic stem/progenitor cells.	26468945
Secondary Graft Failure After Hematopoietic Cell Transplantation	Stem Cell Exhaustion	Secondary failure of platelet recovery (SFPR) is a serious complication observed in approximately 20% of allogeneic hematopoietic stem cell transplant (HSCT) recipients.	26471738
Chronic heart failure	Stem Cell Exhaustion	Increased red cell distribution width is associated with poor stem cell mobilization in patients with advanced chronic heart failure.	26472500
Chronic heart failure, Congestive heart failure	Stem Cell Exhaustion	Parameters associated with poor CD34(+) stem cell mobilization in advanced chronic heart failure (CHF) patients were investigated.	26472500
Congestive heart failure	Stem Cell Exhaustion	Increased RDW was the only independent predictor of poor CD34(+) stem cell mobilization on multivariable analysis and may serve as a biomarker of poor stem cell mobilization in CHF patients.	26472500
leukemia	Stem Cell Exhaustion	After allogeneic stem cell transplantation, regulatory T cells are known to mitigate graft versus host disease while probably maintaining a graft versus leukemia effect.	26473355
Acute lymphocytic leukemia	Stem Cell Exhaustion	Effects of conditioning intensity in allogeneic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia.	26475283
B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1, Complement Membrane Attack Complex	Stem Cell Exhaustion	We retrospectively analyzed the outcomes of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) who underwent first allogeneic stem cell transplantation (allo-SCT) at complete remission (CR) with myeloablative conditioning (MAC, n = 31) or reduced-intensity conditioning (RIC, n = 15) between 2001 and 2012.	26475283
Inflammation	Stem Cell Exhaustion	Plasma levels of a preselected panel miRNA, involved in exercise adaptation processes such as angiogenesis (miR-126, miR-210), inflammation (miR-21, miR-146a), hypoxia/ischemia (miR-21, miR-210), and progenitor cells (miR-150), were quantified by RT-PCR.	26475583
Angioedema	Stem Cell Exhaustion	Non-myeloablative allogeneic stem cell transplantation: a new treatment option for acquired angioedema?	26478549
gastrointestinal	Stem Cell Exhaustion	After allogeneic stem cell transplant, severe grade III-IV gastrointestinal (GI) acute GvHD is associated with significant morbidity and mortality, and generally results in poor outcomes.	26479982
Specialty Type - cancer	Stem Cell Exhaustion	Stem cell transplantation is a treatment option for patients with cancer.	26482109
Specialty Type - cancer	Stem Cell Exhaustion	We retrospectively analyzed the adverse events occurring within 1 hour after infusion in 460 patients with cancer undergoing stem cell transplantation at the Northwestern University Robert H. Lurie Comprehensive Cancer Center from January 1, 2008 and May 1, 2011.	26482109
Irritation - emotion	Stem Cell Exhaustion	To describe a little-known therapy-related small-airway phenomenon presumably caused by mucosal irritation in patients undergoing allogeneic stem cell transplantation (allo-SCT).	26482262
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Presence of a MICA-129Met allele in patients (n = 452) undergoing hematopoietic stem cell transplantation (HSCT) increased the chance of overall survival (hazard ratio [HR] = 0.77, P = 0.0445) and reduced the risk to die due to acute graft-versus-host disease (aGVHD) (odds ratio [OR] = 0.57, P = 0.0400) although homozygous carriers had an increased risk to experience this complication (OR = 1.92, P = 0.0371).	26483398
Specialty Type - cancer	Stem Cell Exhaustion	Pre-treatment peripheral blood CD146+/CD3- cells (as circulating endothelial cells, CECs), CD34+/CD45- cells (as endothelial progenitor cells, EPCs), and CD133+ cells (as cancer stem cells, CSCs) were measured with flow cytometry.	26484608
Infancy	Stem Cell Exhaustion	Improved Outcomes of Hematopoietic Stem Cell Transplantation in Patients With Infantile Malignant Osteopetrosis Using Fludarabine-Based Conditioning.	26485304
Infantile malignant osteopetrosis	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) is the only curative treatment for infantile malignant osteopetrosis (IMO), but is associated with a high incidence of adverse outcomes.	26485304
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We present the case of a 3-year-old female with AML with monosomy 7 and somatic PTPN11 mutation who was refractory to conventional AML chemotherapy but responded to a novel regimen of azacitidine and sorafenib followed by stem cell transplantation.	26485542
Specialty Type - cancer, Non-Small Cell Lung Carcinoma, Neoplasms	Stem Cell Exhaustion	Here we report that the PI3K/Akt1/IL-6/STAT3 signalling pathway regulates generation and stem cell-like properties of Non-Small Cell Lung Cancer (NSCLC) tumor initiating cells (TICs).	26486080
Multiple Myeloma	Stem Cell Exhaustion	Early high-dose therapy (HDT), consisting of high-dose melphalan and autologous stem cell transplantation following doublet or triplet novel agent induction, is a preferred management strategy for transplant-eligible myeloma patients.	26487275
Cytogenetics, Stem cells, Acute lymphocytic leukemia	Stem Cell Exhaustion	B lymphoblastic leukemia is a B progenitor cell neoplasm with a range of immature immunophenotypes and several associated cytogenetic lesions.	26489677
Laryngeal Squamous Cell Carcinoma	Stem Cell Exhaustion	The role of miR-145 in stem cell characteristics of human laryngeal squamous cell carcinoma Hep-2 cells.	26490990
Malignant neoplasm of larynx, Specialty Type - cancer	Stem Cell Exhaustion	In this study, we aimed to explore the role of miR-145, which is downregulated in LSCC, on cancer stem cell potency of laryngeal cancer cells.	26490990
Neoplasms, Secondary Neoplasm, Resistance Process	Stem Cell Exhaustion	Based on these results, we propose that miR-145 might carry crucial roles in LSCC tumorigenesis, prognosis, metastasis, chemoresistance, and recurrence through regulating stem cell properties of tumor cells.	26490990
Specialty Type - cancer	Stem Cell Exhaustion	Exploring long-term cancer survivors' experiences in the career and financial domains: Interviews with hematopoietic stem cell transplantation recipients.	26492184
Specialty Type - cancer	Stem Cell Exhaustion	Using semi-structured interviews with 50 hematopoietic stem cell transplantation (HSCT) recipients who were 2 to 22 years post-transplant, this study investigates cancer survivors' interpretations of their economic and work-related experiences during and after treatment.	26492184
Graft-vs-Host Disease	Stem Cell Exhaustion	Steroid-refractory graft-versus-host disease (GvHD) is a complication following an allogeneic stem cell transplantation with limited therapeutic options.	26492560
Neutropenia	Stem Cell Exhaustion	Filgrastim versus TBO-filgrastim to reduce the duration of neutropenia after autologous hematopoietic stem cell transplantation: TBO, or not TBO, that is the question.	26493022
Multiple Myeloma	Stem Cell Exhaustion	After a hospital-wide formulary change resulted in the replacement of filgrastim with TBO-filgrastim for all on- and off-label indications, we performed a retrospective comparison of patients with myeloma receiving 200 mg/m(2) melphalan with autologous hematopoietic stem cell transplantation to see whether the type of growth factor used post-transplant made a difference.	26493022
Specialty Type - cancer, Infectious Lung Disorder	Stem Cell Exhaustion	The aim of this study was to determine clinical and radiographic characteristics of pulmonary infection due to Legionella in persons undergoing treatment for cancer and stem cell transplant (SCT) recipients.	26496794
Hematologic Neoplasms, Infection, Mycoses	Stem Cell Exhaustion	Radiographic findings were varied-nodular infiltrates mimicking invasive fungal infection were seen only among patients with hematologic malignancy and hematopoietic stem cell transplant (SCT) recipients and were frequently associated with non-pneumophila infections (50% vs 16%; P = 0.0594).	26496794
Secondary Acute Myeloid Leukemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	This report focuses on the adaptive phase I trial design aimed to find the clinically applicable dose for decitabine maintenance treatment after allogeneic hematopoietic stem cell transplantation in patients with higher-risk myelodysplastic syndrome and secondary acute myeloid leukemia.	26497198
Specialty Type - cancer	Stem Cell Exhaustion	Long non-coding RNA HOTAIR (HOX transcript antisense intergenic RNA) is involved in mesenchymal stem cell fate and cancer biology.	26497652
Specialty Type - cancer	Stem Cell Exhaustion	Multipotent mesenchymal stem cells or an aggravated epithelial to mesenchymal transition phenotype of a cancer are integrally involved in pathways conferring chemo-resistance.	26497652
Specialty Type - cancer	Stem Cell Exhaustion	Ubiquitin-specific protease 22 (USP22) is a newly discovered deubiquitinating enzyme and is a cancer stem cell marker that plays a role in tumorigenesis, therapy resistance and cell cycle progression.	26497847
Adult Glioblastoma	Stem Cell Exhaustion	A novel stem cell culture model of recurrent glioblastoma.	26498281
Neoplasms	Stem Cell Exhaustion	Brain tumor stem cells (BTSCs) have been implicated in not only initiating GBM but also conferring resistance to therapy.	26498281
Aspergillosis	Stem Cell Exhaustion	Historically, invasive aspergillosis (IA) has been a major barrier for allogeneic hematopoietic stem cell transplantation (allo-HSCT).	26501769
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cell property was checked by tumor sphere formation and markers including CD133, Nanog, c-Myc, and KLF4.	26503334
Aggressive behavior, Neoplasms	Stem Cell Exhaustion	Increased aggressiveness of this tumor, as well as resistance to standard drug therapies, may be associated with the presence of stem cell populations within the tumor.	26504780
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	Prognostic Value of Cancer Stem Cells Markers in Triple-Negative Breast Cancer.	26504780
Specialty Type - cancer, Aggressive behavior, Neoplasms, Carcinogenesis	Stem Cell Exhaustion	In conclusion, despite the fact that the presence of the cancer stem cells in the tumor provides important information on its potential aggressiveness, today their detection by immunohistochemistry is not sufficient to confirm their role in carcinogenesis, because specific markers probably are not yet identified.	26504780
Adult Glioblastoma, biological adaptation to stress	Stem Cell Exhaustion	Ribosomal Proteins RPS11 and RPS20, Two Stress-Response Markers of Glioblastoma Stem Cells, Are Novel Predictors of Poor Prognosis in Glioblastoma Patients.	26506620
Adult Glioblastoma, Neoplasms	Stem Cell Exhaustion	Glioblastoma stem cells (GSC) co-exhibiting a tumor-initiating capacity and a radio-chemoresistant phenotype, are a compelling cell model for explaining tumor recurrence.	26506620
Stricture of artery	Stem Cell Exhaustion	Reduced endothelial progenitor cells in extracranial arterial stenosis but not intracranial arterial stenosis.	26506942
Cardiovascular Diseases, Endothelial dysfunction	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) are novel markers of endothelial dysfunction and are related to cardiovascular disease.	26506942
Peripheral Stem Cell Transplantation, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In the second case, an 11-year-old boy with acute myeloid leukemia underwent peripheral blood stem cell transplantation (PBSCT).	26508186
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Aggressive strategies, such as eradication of CML stem cells with limited duration and intensive regimens of chemotherapy and TKIs, may be more advantageous in children as a way to avoid lifelong exposure to TKIs and their associated adverse effects.	26511135
Peripheral Arterial Diseases	Stem Cell Exhaustion	Endothelial progenitor cells as a biological marker of peripheral artery disease.	26511986
Peripheral Arterial Diseases	Stem Cell Exhaustion	The role of endothelial progenitor cells (EPCs) in peripheral artery disease (PAD) remains unclear.	26511986
melanoma, senile	Stem Cell Exhaustion	Pluripotent cells-engineered 3D-biologics (PMSB) and control non-3D-biologics were prepared from placenta-based somatic stem cells (PSCs) and inoculated respectively into senile hosts bearing progressive mammary, lung, colon carcinomas and melanoma.	26512920
Cessation of life	Stem Cell Exhaustion	We evaluated associations of demographic variables (race, ethnicity, language, religion, and diagnosis) with end-of-life characteristics (Phase I enrollment, do-not-resuscitate (DNR) orders, hospice utilization, location of death), and trends in palliative care services delivered to pediatric hematology, oncology, and stem cell transplant (SCT) patients.	26513237
Carcinoma, Transitional Cell	Stem Cell Exhaustion	We propose that miR-145 may confer stem cell-like properties on urothelial carcinoma cells and thus facilitate differentiation into multiple cell types.	26514209
Thrombocytosis, Megakaryocytic hyperplasia, Thrombocythemia, Essential	Stem Cell Exhaustion	Essential thrombocythemia (ET) is a clonal hemopoietic stem cell myeloproliferative neoplasm characterized by persistent thrombocytosis along with megakaryocytic hyperplasia.	26514532
Malignant neoplasm of lung	Stem Cell Exhaustion	Secretome of human bone marrow mesenchymal stem cells: an emerging player in lung cancer progression and mechanisms of translation initiation.	26515338
Specialty Type - cancer	Stem Cell Exhaustion	Accumulating data allocate a central role for the cancer microenvironment including mesenchymal stem cells (MSCs) in acquisition of drug resistance and disease relapse.	26515338
How Often Shortness of Breath, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	A 50-year-old man with a history of myelodysplastic syndrome status postallogeneic haematopoietic stem cell transplantation (HSCT) in July 2013 presented in January 2014 with a 6-week history of worsening shortness of breath and dry cough.	26516247
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	CD44 has been identified as a cancer stem cell (CSC) biomarker in various malignancies.	26517627
Prostate carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cell markers in prostate cancer: an immunohistochemical study of ALDH1, SOX2 and EZH2.	26517640
Specialty Type - cancer, Aggressive behavior, Adenocarcinoma of prostate, Prostate carcinoma	Stem Cell Exhaustion	SOX2 showed a statistically significant correlation with lymphovascular invasion only (p = 0.018) in both univariate and multivariate analyses.Cancer stem cell markers are variably expressed in prostate adenocarcinoma and immunohistochemical staining for ALDH1 and EZH2 may have a role in predicting tumour aggressiveness before treatment of prostate cancer.	26517640
Coinfection	Stem Cell Exhaustion	HHV-6 infection after allogeneic hematopoietic stem cell transplantation: From chromosomal integration to viral co-infections and T-cell reconstitution patterns.	26518057
Inflammation	Stem Cell Exhaustion	Telomerase Deficiency Causes Alveolar Stem Cell Senescence-associated Low-grade Inflammation in Lungs.	26518879
Impaired	Stem Cell Exhaustion	In this report, we show that knock-out (KO) of the mouse gene Terc or Tert causes pulmonary alveolar stem cell replicative senescence, epithelial impairment, formation of alveolar sacs, and characteristic inflammatory phenotype.	26518879
Inflammation, Deficiency	Stem Cell Exhaustion	Our data demonstrate for the first time that telomerase deficiency triggers alveolar stem cell replicative senescence-associated low-grade inflammation, thereby driving pulmonary premature aging, alveolar sac formation, and fibrotic lesion.	26518879
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Immune responses to WT1 in patients with AML or MDS after chemotherapy and allogeneic stem cell transplantation.	26519872
Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Here, we analyzed expression of WT1 in 226 peripheral blood and bone marrow samples from patients with acute myeloid leukemia or myelodysplastic syndrome (AML/MDS) before and after allogeneic stem cell transplantation (SCT).	26519872
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Impairment of PI3K/AKT and WNT/b-catenin pathways in bone marrow mesenchymal stem cells isolated from patients with myelodysplastic syndromes.	26521017
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Multiple congenital anomalies	Stem Cell Exhaustion	Bone marrow mesenchymal stem cells (BM-MSCs) exhibit multiple abnormalities in myelodysplastic syndromes (MDS), including impaired proliferative and clonogenic capacity, altered morphology, increased senescence, impaired immunoregulatory properties, and reduced hematopoietic support capacity.	26521017
Specialty Type - cancer, Carcinoma	Stem Cell Exhaustion	Carcinoma cells within larger VI areas expressed significantly higher levels of podoplanin, cancer stem cell marker (P = 0.039); higher numbers of CD34(+) microvessels (P = 0.009), CD204(+) macrophages (P = 0.026), and a-SMA(+) myofibroblasts (P = 0.056) were present within larger VI areas than within smaller VI ones.	26521256
Neoplasm Metastasis, Specialty Type - cancer	Stem Cell Exhaustion	Our results indicate that larger VI areas are a predictor for recurrence in lung SCC; also, within the larger blood vessel, cancer stem cells and abundant stromal cells can create a more favorable microenvironment for tumor metastasis.	26521256
Concomitant Medication Submission Domain, Degenerative polyarthritis	Stem Cell Exhaustion	To define whether good manufacturing practice (GMP)-clinical grade adipose stem cell (ASC)-derived conditioned medium (CM) is as effective as GMP-ASC in modulating inflammatory and catabolic factors released by both osteoarthritis (OA) chondrocytes or synoviocytes.	26521751
Graft-vs-Host Disease	Stem Cell Exhaustion	alemtuzumab as graft-versus-host disease (GVHD) prophylaxis for matched unrelated donor stem cell transplantations.	26524732
Aplastic Anemia	Stem Cell Exhaustion	BM cellularity in ITP may represent an impairment and/or lower responsiveness of pluripotent hematopoietic stem cells, not limited to the megakaryocyte (MgK) -platelet axis, to endogenous TPO, because recent evidence shows that TPO-RA can successfully restore hematopoiesis in aplastic anemia.	26524893
Osteoporosis, Frailty	Stem Cell Exhaustion	Association Between Circulating Osteogenic Progenitor Cells and Disability and Frailty in Older Persons: The Nepean Osteoporosis and Frailty Study.	26525092
Malignant neoplasm of ovary	Stem Cell Exhaustion	A Phase I Trial of High-Dose Chemotherapy Combining Topotecan plus Cyclophosphamide with Hematopoietic Stem Cell Transplantation for Ovarian Cancer: The ITOV 01bis Study.	26528705
Malignant neoplasm of ovary	Stem Cell Exhaustion	Dose-intensive chemotherapy with hematopoietic stem cell transplantation has been evaluated as a salvage treatment for recurrent ovarian cancer, but its benefit has not yet been demonstrated.	26528705
Toxic effect	Stem Cell Exhaustion	Although hematopoietic toxicities were overcome by peripheral blood stem cell transplantation, superior nonhematological toxicities were observed as compared to the initial trial.	26528705
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Outcomes of Allogeneic Stem Cell Transplantation in Elderly Patients with Acute Myeloid Leukemia: A Systematic Review and Meta-analysis.	26529178
Toxic effect, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A large number of elderly patients with acute myeloid leukemia (AML) are not offered treatments with curative intent, such as allogeneic stem cell transplantation (SCT), because of fears of toxicity and perceived futility of intensive treatment.	26529178
Malignant tumor of cervix, Specialty Type - cancer	Stem Cell Exhaustion	Clinical significance of Gremlin 1 in cervical cancer and its effects on cancer stem cell maintenance.	26530461
Neoplasms	Stem Cell Exhaustion	Recent studies suggest that latexin (Lxn) expression is involved in stem cell regulation and that it plays significant roles in tumor cell migration and invasion.	26530530
Multiple Myeloma	Stem Cell Exhaustion	Evaluation of low-dose thalidomide as induction and maintenance therapy in patients with multiple myeloma not eligible for stem cell transplantation.	26531225
Multiple Myeloma	Stem Cell Exhaustion	The role of thalidomide in induction and long-term maintenance therapy in patients with multiple myeloma not eligible for stem cell transplantation remains unclear.	26531225
Childhood Breast Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Breast cancer samples contained about 2.7% of cancer stem like SP cells which possessed elevated mRNA expression of stem cell proteins Oct-4, EpCAM and ABC transporter ABCG2, essential for the maintenance of SP cells.	26537077
Childhood Breast Carcinoma	Stem Cell Exhaustion	Elevated survivin mediated multidrug resistance and reduced apoptosis in breast cancer stem cells.	26537077
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GVHD) complicates half of hematopoietic stem cell transplants (HCT), and the gastrointestinal tract is commonly affected.	26537485
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Normal karyotype acute myeloid leukemia patients with CEBPA double mutation have a favorable prognosis but no survival benefit from allogeneic stem cell transplant.	26537612
Neoplastic Cell Transformation	Stem Cell Exhaustion	The SRY (sex determining region Y)-box 2 gene, SOX2, is an essential embryonic stem cell gene involved in prostate tumorigenesis.	26540632
Primordial follicles	Stem Cell Exhaustion	Data has accumulated in support of ovarian stem cells (OSCs) proliferation, maintenance in culture, formation of germ cell nests and differentiation into oocytes and primordial follicle assembly using different strategies.	26542369
Neoplasms, Prostate carcinoma, Specialty Type - cancer, Usual Severity Pain	Stem Cell Exhaustion	The secondary endpoints included the tumor response rate (RECIST 1.0), safety (National Cancer Institute Common Terminology Criteria for Adverse Events, version 3.0), quality of life (Functional Assessment of Cancer Therapy-Prostate [FACT-P]), pain (Present Pain Intensity [PPI] scale), prostate-specific antigen (PSA) parameters, including time to PSA progression (TTPP) according to Prostate Cancer Clinical Trials Working Group criteria, and serial enumeration of circulating endothelial cells (CECs) and endothelial progenitor cells (CEPs).	26542984
Kidney Failure, Chronic, Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Human mesenchymal stem cells alter the gene profile of monocytes from patients with Type 2 diabetes and end-stage renal disease.	26544198
Adult Glioblastoma	Stem Cell Exhaustion	Here we used MGMT-expressing glioblastoma stem cells (GSC) lines as a model for investigating the molecular mechanism underlying TMZ resistance, while aiming to explore a new treatment strategy designed to possibly overcome resistance to the clinically relevant dose of TMZ (35 mM).	26546412
Autosomal recessive inheritance, Dyskeratosis Congenita	Stem Cell Exhaustion	A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition.	26546739
Vascular System Injuries	Stem Cell Exhaustion	The number of circulating endothelial cells (CEC) and endothelial progenitor cells (EPC) might reflect the balance between vascular injury and repair.	26552487
Bronchopleural Fistula, CTCAE	Stem Cell Exhaustion	This preliminary study showed that bronchoscopic application of autologous adipose-derived stem cells is a feasible, safe and effective procedure for treating bronchopleural fistula.	26552766
Neoplasms	Stem Cell Exhaustion	This case supports the hypothesis that these tumors share a common progenitor cell, which could be the folliculostellate cell.	26553184
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Chronic myeloid leukemia (CML) originates from normal hematopoietic stem cells acquiring Philadelphia chromosome (Ph) to generate BCR-ABL fusion gene whose protein product has deregulated tyrosine kinase activity.	26554155
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Modulating the Growth and Imatinib Sensitivity of Chronic Myeloid Leukemia Stem/Progenitor Cells with Pullulan/MicroRNA Nanoparticles In Vitro.	26554155
Specialty Type - cancer, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Delivery of microRNA (miRNA) using non-viral vectors has been utilized to inhibit various cancer cells; however, the efficacy of this approach to target CML stem/progenitor cells has not been elucidated.	26554155
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Taken together, we have therefore demonstrated that the delivery of miR-181a using Ps to CML stem/progenitor cells leads to their growth inhibition and enhancement of IM sensitivity, which will possibly be beneficial to CML treatment.	26554155
Facet joint structure	Stem Cell Exhaustion	Isolation and Characterization of Human Mesenchymal Stem Cells From Facet Joints and Interspinous Ligaments.	26555840
Facet joint structure	Stem Cell Exhaustion	A descriptive in vitro study on isolation and differentiation of human mesenchymal stem cells (MSCs) derived from the facet joints and interspinous ligaments.	26555840
Inflammatory disorder	Stem Cell Exhaustion	Mesenchymal stem cells are known to exert immunomodulatory effects in inflammatory diseases.	26558442
Rheumatoid Arthritis	Stem Cell Exhaustion	Interleukin 17 inhibits progenitor cells in rheumatoid arthritis cartilage.	26558442
Rheumatoid Arthritis, Inflammation	Stem Cell Exhaustion	Here, we studied progenitor cells from RA cartilage (RA-CPCs) that are positive for IL-17 receptors to determinate the effects of inflammation on their chondrogenic potenial.	26558442
Multiple Myeloma	Stem Cell Exhaustion	CXCR4-targeted radiotherapy with pentixather appears to be a promising novel treatment option in combination with cytotoxic chemotherapy and autologous stem cell transplantation, especially for patients with advanced multiple myeloma.	26564323
Acute leukemia	Stem Cell Exhaustion	Peripheral blood stem cell graft compared to bone marrow after reduced intensity conditioning regimens for acute leukemia: a report from the ALWP of the EBMT.	26565001
leukemia, Acute leukemia	Stem Cell Exhaustion	Patients who underwent reduced intensity conditioning regimen allogeneic hematopoietic stem cell transplantation from 2000 to 2012 for acute leukemia, and who were reported to the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation were included in the study.	26565001
Breast Carcinoma, Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	BRCAmut tumors bear stem cell characteristics displaying a distinct cell adhesion molecule profile characterized by high expression of CDH1 and CLDN4 according to public gene expression data set analysis, and higher claudin-3 expression as detected by IHC; thus, BRCAmut breast carcinomas are not identical with the previously identified claudin-low subtype of breast cancer.	26566278
Specialty Type - cancer	Stem Cell Exhaustion	However, the molecular mechanisms that underlie modulation of cancer stem cells (CSCs) in NPC remain unclear.	26568302
Lymphoma	Stem Cell Exhaustion	Thiotepa-based high-dose therapy for autologous stem cell transplantation in lymphoma: a retrospective study from the EBMT.	26569093
Primary central nervous system lymphoma	Stem Cell Exhaustion	Clinical information about thiotepa-based autologous stem cell transplantation (auto-SCT) outside the primary central nervous system lymphoma (PCNSL) field is sparse.	26569093
Specialty Type - cancer	Stem Cell Exhaustion	Primary cultures of mucin- and mixed-IHCCA were characterized by a different pattern of expression of cancer stem cell markers, and by a different drug sensitivity.	26571380
Specialty Type - cancer	Stem Cell Exhaustion	Aldehyde dehydrogenase isoform 1 (ALDH1) has been shown to be a marker of cancer stem cells (CSCs).	26572760
Neoplasms	Stem Cell Exhaustion	These stem cells may be responsible for tumour perpetuation as well as local and distant invasion.	26572760
diabetic	Stem Cell Exhaustion	We have evaluated the cellularity and frequency of osteogenic mesenchymal stem cells (MSCs) in bone marrow from 54 diabetic patients (12 with type 1 and 42 with type 2) with tibial non-unions.	26572889
diabetic	Stem Cell Exhaustion	We recommend that diabetic patients be treated with an increased number of progenitor cells by increasing the bone marrow aspiration volume.	26572889
MS gene	Stem Cell Exhaustion	Oligodendrocyte progenitor cell (OPC) differentiation is an important therapeutic target to promote remyelination in multiple sclerosis (MS).	26576485
Acute myocardial infarction	Stem Cell Exhaustion	The chemokine receptor CXCR4 has emerged as a therapeutic target after acute myocardial infarction (AMI), because of its role in inflammatory and progenitor cell recruitment.	26577262
Craniosynostosis	Stem Cell Exhaustion	Data from patients treated with CRS alone (N = 18) or CRS and HIO (N = 62) were used to estimate the baseline platelet count (PLT0), rate constants for platelet maturation (k tr ) and platelet random destruction (k s ), feedback on progenitor cell proliferation (g), and the drug-specific model parameters (a, b).	26577587
Schizophrenia, Deficit	Stem Cell Exhaustion	In order to gain insight into the possible neurobiological mechanisms of myelin deficit, we determined the messenger RNA (mRNA) expression profile of laser captured cells that were immunoreactive for 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), a marker for oligodendrocyte progenitor cells (OPCs) in addition to differentiating and myelinating oligodendrocytes, in the white matter of the prefrontal cortex in schizophrenia subjects.	26585218
Cartilage	Stem Cell Exhaustion	To compare the clinical and radiologic efficacy of adipose-derived stem cells (ADSCs) with fibrin glue and microfracture (MFX) versus MFX alone in patients with symptomatic knee cartilage defects.	26585585
Having administered	Stem Cell Exhaustion	PTH Induces Systemically Administered Mesenchymal Stem Cells to Migrate to and Regenerate Spine Injuries.	26585691
Fracture	Stem Cell Exhaustion	Parathyroid hormone (PTH) was shown to induce fracture repair in animals by activating mesenchymal stem cells (MSCs).	26585691
Natural Killer Cells	Stem Cell Exhaustion	Natural killer cell tumors can be broadly divided by origin into mature-cell and progenitor-cell types.	26585973
Atrophic	Stem Cell Exhaustion	Furthermore, in vitro, AGEs (in a dose-dependent manner) reduced myotube diameters (myotube atrophy) and induced Atrogin-1 protein expression in myotubes differentiated from both mouse myoblasts and primary human skeletal muscle-derived progenitor cells.	26586640
Malignant Neoplasms	Stem Cell Exhaustion	The Shreveport Myeloma Experience: Survival, Risk Factors and Other Malignancies in the Age of Stem Cell Transplantation.	26588024
Myocardial Ischemia	Stem Cell Exhaustion	Smoking impairs and circulating stem cells favour the protective effect of the T allele of the connexin37 gene in ischemic heart disease--A multinational study.	26588185
Mucopolysaccharidoses	Stem Cell Exhaustion	A Case of a Bilateral Cicatricial Upper Eyelid Entropion After Hematopoietic Stem Cell Transplantation in Mucopolysaccharidosis Type I.	26588207
conjunctiva, Corneal erosion, Excessive tearing, Mucopolysaccharidoses	Stem Cell Exhaustion	The authors report a clinical case of severe bilateral cicatricial entropion of the upper eyelids, leading to recurrent conjunctival infections, corneal erosion, persistent epiphora, and a major decline in life quality in a 7-year-old boy with mucopolysaccharidosis type I who underwent hematopoietic stem cell transplantation at 1.6 years old.	26588207
Lymphopenia, Hyposplenia	Stem Cell Exhaustion	E2A-HLF expression in B-cell progenitors induced hyposplenia and lymphopenia, whereas expression in hematopoietic stem/progenitor cells was embryonic lethal.	26588248
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Monosomal karyotype as an adverse prognostic factor in patients with acute myeloid leukemia treated with allogeneic hematopoietic stem-cell transplantation in first complete remission: a retrospective survey on behalf of the ALWP of the EBMT.	26589909
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Despite the overall benefit from allogeneic hematopoietic stem cell transplantation observed in patients with poor cytogenetic risk acute myeloid leukemia in first complete remission, the precise effect of this procedure for different poor-risk subtypes has not been fully analyzed.	26589909
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In summary, monosomal karyotype arises as a strong negative prognostic feature in acute myeloid leukemia also in patients who undergo allogeneic hematopoietic stem cell transplantation in first complete remission, stressing the need to develop additional pre- and post-transplantation strategies aimed at improving overall results.	26589909
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Nonetheless, allogeneic hematopoietic stem cell transplantation in early phase is currently the best therapy for this very poor-risk acute myeloid leukemia subtype.	26589909
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	CD4+ T cells from patients with acute myeloid leukemia inhibit the proliferation of bone marrow-derived mesenchymal stem cells by secretion of miR-10a.	26590574
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The abnormality of bone marrow-derived mesenchymal stem cells (BM-MSCs) has been reported to contribute to the pathogenesis of acute myeloid leukemia (AML).	26590574
Neutropenia	Stem Cell Exhaustion	Use of proton pump inhibitors in hematopoietic stem cell transplantation does not increase the frequency of febrile neutropenia.	26592835
Febrile Neutropenia, Infection	Stem Cell Exhaustion	Despite the fact that proton pump inhibitor (PPI) use is a risk factor for infections in heterogeneous groups of patients, there are only a limited data related to PPI use and febrile neutropenic episodes (FNEs) in hematopoietic stem cell transplantation (HSCT) patients.	26592835
Multiple Myeloma	Stem Cell Exhaustion	High-dose melphalan plus autologous stem-cell transplantation (ASCT) is the standard approach in transplant-eligible patients with newly diagnosed myeloma.	26596670
Colorectal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Lgr5 Methylation in Cancer Stem Cell Differentiation and Prognosis-Prediction in Colorectal Cancer.	26599100
Colorectal Carcinoma	Stem Cell Exhaustion	Leucine-rich-repeat-containing G-protein-coupled receptor 5 (lgr5) is a candidate marker for colorectal cancer stem cells (CSC).	26599100
Hereditary Diseases	Stem Cell Exhaustion	Characterization of neurons from immortalized dental pulp stem cells for the study of neurogenetic disorders.	26599327
Mucopolysaccharidoses, Sleep Apnea, Obstructive, Sleep Apnea Syndromes, Mucopolysaccharidosis I	Stem Cell Exhaustion	Obstructive sleep apnea syndrome after hematopoietic stem cell transplantation in children with mucopolysaccharidosis type I. Obstructive sleep apnea syndrome (OSAS) is very common in mucopolysaccharidosis I (MPS I).	26602600
Mucopolysaccharidosis I	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) is the preferred treatment for patients with severe MPS I diagnosed early in life.	26602600
Lymphoma, T-Cell, Cutaneous	Stem Cell Exhaustion	Hematopoietic stem cell transplantation for cutaneous T-cell lymphoma: Summary of 11 cases from two facilities in Japan and Brazil.	26602996
TSPYL2 gene, Lymphoma, T-Cell, Cutaneous	Stem Cell Exhaustion	Some patients with cutaneous T-cell lymphoma (CTCL) show a miserable clinical course and the only option that can induce long-term remission for advanced CTCL may be hematopoietic stem cell transplantation (HSCT).	26602996
Pneumocystis jiroveci pneumonia	Stem Cell Exhaustion	Retrospective review of intravenous pentamidine for Pneumocystis pneumonia prophylaxis in allogeneic hematopoietic stem cell transplantation.	26606757
Opportunistic Infections	Stem Cell Exhaustion	Patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) are at risk of numerous opportunistic infections.	26606757
Lipolysis, Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	We characterised subcutaneous abdominal adipose tissue by examining stromal cell populations by 13 colour flow cytometry, measuring expression of adipogenesis genes in the progenitor cell fraction and determining lipolysis and adipose secretion of inflammatory proteins in 14 non-obese men with type 2 diabetes and 13 healthy controls matched for age, sex, body weight and total fat mass.	26607638
Hypertrophy, Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	We show that a major phenotype of white adipose tissue in non-obese individuals with type 2 diabetes is adipocyte hypertrophy, which may be mediated by an impaired adipogenic capacity in progenitor cells.	26607638
Kidney Diseases, Communicable Diseases	Stem Cell Exhaustion	Nephropathy due to BK virus (BKV) infection is an evolving challenge in patients undergoing hematopoietic stem cell transplantation (HSCT).	26608093
Steroid-Refractory Pneumonitis, Acute GVH disease	Stem Cell Exhaustion	Bone marrow-derived mesenchymal stem cells (JR-031) for steroid-refractory grade III or IV acute graft-versus-host disease: a phase II/III study.	26608364
Graft-vs-Host Disease, Steroid-Refractory Pneumonitis, Acute GVH disease	Stem Cell Exhaustion	Following a phase I/II study using mesenchymal stem cells (MSCs; JR-031) for steroid-refractory grade II or III acute graft-versus-host disease (aGVHD), a phase II/III study using the cells focused on steroid-refractory grade III or IV aGVHD was conducted.	26608364
Endometrial Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Immunohistochemical expression of cancer stem cell related markers CD44 and CD133 in endometrial cancer.	26608413
Behavior of tumor, Endometrial Carcinoma, Specialty Type - cancer, Carcinogenesis	Stem Cell Exhaustion	The goal of this study was to detect the presence of cancer stem cell markers CD44 and CD133 in immunohistochemically stained samples of endometrial cancer and correlate their expression with clinicopathological variables to identify the impact of CD44 or CD133 expression on tumor behavior and endometrial carcinogenesis.	26608413
Pregnancy Complications, Infectious, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The patient successfully underwent stem cell transplantation with continuing antifungal treatment and finally completely recovered from both the AML and infectious complications.	26608844
Liver carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells in hepatocellular carcinoma--an immunohistochemical study with histopathological association.	26609030
Liver carcinoma, Hollings Cancer Center, Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSCs) may be responsible for tumour recurrence and resistance to chemotherapy in hepatocellular carcinoma (HCC).	26609030
Neoplasms	Stem Cell Exhaustion	Immunohistochemical staining for the LCSC marker EpCAM (epithelial cell adhesion molecule), liver progenitor cell (LPC) markers CK19 (cytokeratin 19) and neural cell adhesion molecule (NCAM) were performed and were associated with histological features of tumour behaviour.	26609030
Hematological Disease	Stem Cell Exhaustion	Allogeneic stem cell transplantation is commonly used in the treatment of younger patients with severe hematological diseases, and endothelial cells seem to be important for the development of several posttransplant complications.	26609191
Acute lymphocytic leukemia, Childhood Non-Hodgkin Lymphoma, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	A total of 14,951 patients with acute myeloid leukemia, acute lymphocytic leukemia, myelodysplastic syndrome and non-Hodgkin lymphoma transplanted with peripheral blood stem cells or bone marrow grafts were included.	26611475
Lymphoma	Stem Cell Exhaustion	Increased efficacy of intermediate-dose cytarabine + G-CSF compared to DHAP + G-CSF for stem cell mobilization in patients with lymphoma: an analysis by the polish lymphoma research group.	26611854
Lymphoma	Stem Cell Exhaustion	Salvage regimens, like DHAP (dexamethasone, cytarabine, and cisplatin) are frequently used for stem cell mobilization in lymphoma.	26611854
Lymphoma	Stem Cell Exhaustion	We conclude that stem cell mobilization using ID-AraC is associated with a significantly higher efficacy than DHAP, allowing for collection of the transplant material in almost all patients with lymphoma.	26611854
Graft-vs-Host Disease, Stable chronic Graft vs Host Disease	Stem Cell Exhaustion	In a retrospective analysis of 102 allogeneic hematopoietic stem cell transplant (HSCT) patients, incidences of overall and severe aGvHD (>IIdeg), cGvHD as well as overall and severe (CTC >IIdeg) GI-toxicities were compared between GvHD prophylaxis containing EC-MPS vs. MMF or MTX (control group).	26613546
Neoplasms, Fibrous Tissue	Stem Cell Exhaustion	Immunohistochemical evaluation of stem cell markers and signal transducer and activator of transcription 6 (STAT6) in solitary fibrous tumors.	26617768
Neoplasms	Stem Cell Exhaustion	To analyze the immunophenotype of SFT for the identification of specific diagnostic markers and the cell of origin of this tumor, we performed an immunohistochemical study of stem cell markers [aldehyde dehydrogenase 1 (ALDH1), CD29, CD44, CD133, and nestin] and signal transducer and activator of transcription 6 (STAT6) in 18 cases of SFT.	26617768
Childhood Breast Carcinoma	Stem Cell Exhaustion	Cells with unique phenotypes and stem cell-like properties have been found to exist in breast cancer.	26617852
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Acute leukemia	Stem Cell Exhaustion	Impact of conditioning with TBI in adult patients with T-cell ALL who receive a myeloablative allogeneic stem cell transplantation: a report from the acute leukemia working party of EBMT.	26618548
Adult T-Cell Lymphoma/Leukemia, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (allo-SCT) is a therapeutic option for adult patients with T-cell ALL (T-ALL).	26618548
Exfoliative dermatitis, Angioimmunoblastic Lymphadenopathy, Pruritus	Stem Cell Exhaustion	We report a case of a patient with angioimmunoblastic T-cell lymphoma presenting initially with pruritus and saggy skin, which later progressed into erythroderma despite chemotherapy; the disease eventually resolved with autologous stem cell transplant.	26620295
LIPC gene	Stem Cell Exhaustion	For HL, the indication is restricted to treatment after autologous stem cell transplantation (ASCT) or after at least two previous therapies when ASCT or multiagent chemotherapy is not a treatment option.	26621039
Hodgkin Disease	Stem Cell Exhaustion	For Hodgkin lymphoma, brentuximab vedotin should only be used after autologous stem cell transplantation or following at least two prior therapies when transplantation or multiagent chemotherapy is not a treatment option.	26621039
Specialty Type - cancer, Ductal Breast Carcinoma	Stem Cell Exhaustion	Clinicopathological Significance of CD133 and ALDH1 Cancer Stem Cell Marker Expression in Invasive Ductal Breast Carcinoma.	26625750
Specialty Type - cancer, Ductal Breast Carcinoma	Stem Cell Exhaustion	We investigated the possible correlation between cancer stem cell (CSC) markers (CD133, and ALDH1) in invasive ductal breast carcinomas with some clinicopathological parameters.	26625750
Specialty Type - cancer, Ductal Breast Carcinoma	Stem Cell Exhaustion	To assess the correlation between expression of cancer stem cell (CSC) markers (CD133, and ALDH1) and clinicopathological parameters of invasive ductal breast carcinomas.	26625750
Amyloidosis	Stem Cell Exhaustion	The impact of dialysis on the survival of patients with immunoglobulin light chain (AL) amyloidosis undergoing autologous stem cell transplantation.	26627634
Kidney Failure, Acute	Stem Cell Exhaustion	Acute renal failure requiring dialysis is associated with high mortality during autologous stem cell transplantation (ASCT).	26627634
Lupus Nephritis	Stem Cell Exhaustion	Human embryonic stem cell-derived mesenchymal cells preserve kidney function and extend lifespan in NZB/W F1 mouse model of lupus nephritis.	26628350
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	GBM is essentially incurable and its resistance to therapy is attributed to a subpopulation of cells called glioma stem cells (GSCs).	26629530
Veins, Hyperemia, Atherosclerosis	Stem Cell Exhaustion	Effect of Extended-Release Niacin on Carotid Intima Media Thickness, Reactive Hyperemia, and Endothelial Progenitor Cell Mobilization: Insights From the Atherosclerosis Lesion Progression Intervention Using Niacin Extended Release in Saphenous Vein Grafts (ALPINE-SVG) Pilot Trial.	26630643
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Expressions of stem cell transcription factors Nanog and Oct4 in renal cell carcinoma tissues and clinical significance.	26631537
Renal Cell Carcinoma Pathway, Refractory Cytopenia of Childhood	Stem Cell Exhaustion	We aimed to detect the expressions of stem cell transcription factors Nanog and Oct4 in renal cell carcinoma (RCC) tissues.	26631537
Leukemia, Myelocytic, Acute, Myeloid neoplasm	Stem Cell Exhaustion	Allogeneic stem cell transplantation (allo-HCT) represents the most effective immunotherapy for acute myeloid leukemia (AML) and myeloid malignancies.	26631751
Experimental Organism Basal Cell Carcinoma	Stem Cell Exhaustion	It is unknown whether the histologic subtypes of basal cell carcinoma (BCC) arise from a common progenitor cell or whether other factors play a role in their development.	26631769
Fever, Leukemia, Myelocytic, Acute, Pichia kudriavzevii	Stem Cell Exhaustion	During hospitalization for neutropenic fever, a 19-year-old man with acute myeloid leukemia, who underwent hematopoietic stem cell transplantation, developed a generalized folliculocentric eruption following initiation of antifungal therapy for newly diagnosed C. krusei fungemia.	26632935
Diabetes, Coronary heart disease	Stem Cell Exhaustion	Aging and diabetes were the major risk factors that influence the level and function of bone marrow resident progenitor cells in patients with coronary heart disease undergoing CABG.	26634486
leukemia, Haploidentical Hematopoietic Cell Transplantation	Stem Cell Exhaustion	Treatment of childhood leukemia with haploidentical hematopoietic stem cell transplantation using parent as donor: a single-center study of 111 case.	26636526
Pancreatic carcinoma	Stem Cell Exhaustion	In this study, we measured ROR in 61 paired cancerous and noncancerous tissue samples by qRT-PCR and investigated the biological role of ROR on the phenotypes of pancreatic cancer stem cells (PCSCs) in vitro and in vivo.	26636540
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	The role of autologous hematopoietic stem cell transplantation (ASCT) in the management of non-Hodgkin's lymphoma (NHL) is evolving, in the era of novel agents.	26637704
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	PV-T tumors were associated with higher expression of two proneural and cancer stem cell genes, NOTCH1 (p = 0.028) and PROM1 (p = 0.033) while PV-FP tumors were characterized by high expression of a mesenchymal gene, CHI3L1 (p = 0.006).	26637806
Teratoma	Stem Cell Exhaustion	Most teratomas contained cells differentiating into astrocytes positive for nestin, a neural stem cell marker.	26638157
Diabetes Mellitus	Stem Cell Exhaustion	Fetal Pancreatic Stem-Cell Transplant in Patients With Diabetes Mellitus.	26640941
Diabetes Mellitus	Stem Cell Exhaustion	To determine the efficacy of fetal stem cell transplant for treating patients with diabetes mellitus types 1 and 2.	26640941
Diabetes Mellitus	Stem Cell Exhaustion	Five patients with diabetes mellitus type 1 and 5 patients with diabetes mellitus type 2 (aged 18-56 years) received a fetal pancreatic stem-cell transplant (cells were 16-18 wk gestation) performed by intravenous infusion at 50 mL/hour.	26640941
Diabetes Mellitus	Stem Cell Exhaustion	In patients with diabetes mellitus type 1, fetal stem-cell transplant led to a significant increase in C-peptide levels, from 0.09 +- 0.01 ng/mL to 0.20 +- 0.07 ng/mL, after 3 months (P < .008).	26640941
Diabetes	Stem Cell Exhaustion	Treatment with fetal pancreatic stem cells may be beneficial for treating patients with type 1 or type 2 diabetes.	26640941
Cytomegalovirus Infections	Stem Cell Exhaustion	Preemptive antiviral therapy for CMV infection in allogeneic stem cell transplant recipients guided by the viral doubling time in the blood.	26642339
PAFAH1B1 wt Allele, leukemia	Stem Cell Exhaustion	Leukemia stem cells (LSC) in MDS might be contained in those cells.	26642704
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	The optimal treatment for use as a bridge to allogeneic hematopoietic stem cell transplantation at the decision for transplantation has not been established in patients with myelodysplastic syndrome (MDS).	26643559
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Despite the recent evidence of the existence of myelodysplastic syndrome (MDS) stem cells in 5q-MDS patients, it is unclear whether haematopoietic stem cells (HSCs) could also be the initiating cells in other MDS subgroups.	26643973
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Stem cell transplantation for acute myeloid leukemia with pulmonary and cerebral mucormycosis.	26645867
Zygomycosis, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We retrospectively evaluated the efficacy of stem cell transplantation for a pediatric patient with refractory acute myeloid leukemia (AML) who developed mucormycosis.	26645867
Zygomycosis, Hematological Disease	Stem Cell Exhaustion	Stem cell transplantation could reduce the mortality of patients with hematologic disease who develop mucormycosis.	26645867
Specialty Type - cancer, Squamous cell carcinoma	Stem Cell Exhaustion	CD44v3+/CD24- cells possess cancer stem cell-like properties in human oral squamous cell carcinoma.	26647656
Specialty Type - cancer, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Cancer stem cells (CSCs) or cancer stem cell-like cells (CSC-LCs) are a minority population of cells that relate to tumor progression, metastasis and drug resistance.	26647656
Hollings Cancer Center, Neoplasms	Stem Cell Exhaustion	Liver progenitors or stem cells could be a potential therapy for HCC treatment since they migrate toward tumors.	26647726
Passive Cutaneous Anaphylaxis	Stem Cell Exhaustion	The expression of 6 miRs that have been previously reported to be downregulated in PCa stem cells were examined in a total of 32 recurrent and 36 non-recurrent PCa samples, and let-7a was substantially decreased in the recurrent PCa.	26648141
Hypoxia	Stem Cell Exhaustion	Though recent studies have revealed that stem cells of many tissues are harbored in hypoxic microenvironment, little is known about the relationship between hypoxia and intestinal crypt base, where intestinal stem cells are supposed to exist.	26648507
Thoracic Injuries, Traumatic Brain Injury, Traumatic	Stem Cell Exhaustion	To determine the impact of traumatic brain injury (TBI) and chest trauma (CT) on the number of peripheral blood (PB) stem cells in affected patients in comparison to normal controls.	26649467
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Presence of B haplotype KIR in donors is associated with a lower relapse risk for acute myeloid leukemia (AML) after hematopoietic stem cell transplants (HSCT).	26649563
Post-Traumatic Stress Disorder	Stem Cell Exhaustion	Quality of life and mood predict posttraumatic stress disorder after hematopoietic stem cell transplantation.	26650840
Arterial calcification	Stem Cell Exhaustion	At the cellular level, there was a greater presence of pericytes in OM+ compared with OM- lesions (5.59 +- 1.09 vs. 2.42 +- 0.58, percentage of area staining [region of interest]; p = .04); in vitro, pericytes were able to inhibit the osteoblastic differentiation of human mesenchymal stem cells, suggesting that they are involved in regulating arterial calcification.	26652270
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are a heterogenous group of clonal hematopoietic stem cell disorders characterized by increased risk of leukemic transformation.	26657287
Hollings Cancer Center	Stem Cell Exhaustion	A sorafenib-resistance 175 gene signature was characterised by enrichment of progenitor cell features, aggressive tumorous traits and predicted poor survival in two cohorts (n=442 patients with HCC).	26658144
Specialty Type - cancer, Carcinoma, Transitional Cell	Stem Cell Exhaustion	Gemcitabine and mitomycin induced autophagy regulates cancer stem cell pool in urothelial carcinoma cells.	26658162
Specialty Type - cancer, Ulcerative Colitis	Stem Cell Exhaustion	It has been suggested that UC are driven by a rare subset of cancer stem cells (CSCs).	26658162
Graft-vs-Host Disease, Toxic effect, Acute GVH disease	Stem Cell Exhaustion	Methotrexate (MTX) toxicity can hamper the administration of all planned doses in acute graft-versus-host disease (GVHD) prophylaxis following allogeneic hematopoietic stem cell transplantation.	26658911
Graft-vs-Host Disease, Nephrotic Syndrome, Nuclear non-senile cataract, Chronic graft-versus-host disease	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT)-related nephrotic syndrome (NS) is a rare event and has been described as a clinical form of chronic graft-versus-host disease (GVHD).	26659462
Liver diseases	Stem Cell Exhaustion	Several clinical experiments have been reported on the safety of bone marrow-derived stem cells to treat liver disorders.	26659833
Clostridium difficile infection	Stem Cell Exhaustion	Peri-transplant clostridium difficile infections in patients undergoing allogeneic hematopoietic progenitor cell transplant.	26661725
Hematologic Neoplasms, Central Diabetes Insipidus	Stem Cell Exhaustion	Patients with hematologic malignancies, especially those who undergo hematopoietic progenitor cell transplants are particularly at risk for developing CDI.	26661725
Clostridium difficile infection	Stem Cell Exhaustion	One hundred and forty seven consecutive allogeneic hematopoietic progenitor cell transplants were analyzed for peri-transplant Clostridium difficile infections (PT-CDI).	26661725
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Impact of age on outcomes of allogeneic hematopoietic stem cell transplantation with reduced intensity conditioning in elderly patients with acute myeloid leukemia.	26663096
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Previous studies have repeatedly reported that increasing age is a significant risk factor for worse outcomes after allogeneic hematopoietic stem cell transplantation (allo-HSCT) among patients with acute myeloid leukemia (AML).	26663096
Myeloid Leukemia, Chronic, Chromosome Aberrations	Stem Cell Exhaustion	CML = Chronic Myeloid Leukemia, BCR-ABL1 = Break Cluster Region - Abelson gene, TKI = tyrosine kinase inhibitor treatment, ACAs = additional cytogenetic abnormalities, CCyR = complete cytogenetic response, PCyR = partial cytogenetic response, mCyR = minor cytogenetic response, MMR = major molecular response, HSCT = hematopoietic stem cell transplant, HLA = human leukocyte antigens, CP = chronic phase, AP = accelerated phase, BP = blast phase, OS = overall survival, CBA = chromosome banding analysis, +8 = trisomy 8, i(17q) = isochromosome (17q), +Ph = second Philadelphia chromosome, -7 = monosomy 7, -17 = monosomy 17, +17 = trisomy 17, -21 = monosomy 21, +21 = trisomy 21, -Y = loss of Y chromosome, ELN = European LeukemiaNet, IMA600 = Imatinib 600 mg daily, IMA400 = Imatinib 400 mg daily, NILO600 = Nilotinib 600 mg daily, DASA100 = Dasatinib 100mg daily, DASA140 = Dasatinib 140 mg daily.	26664479
Abnormal vision	Stem Cell Exhaustion	To report bone marrow derived stem cell application in a patient with bilateral visual loss due to accidental ingestion of methanol.	26665934
Abnormal vision	Stem Cell Exhaustion	Treatment with retrobulbar and intrathecal autologous bone marrow derived stem cell in an adult male patient with bilateral visual loss due to accidental ingestion of methanol was effective.	26665934
Blindness	Stem Cell Exhaustion	Therapeutic Application of Bone Marrow-Derived Stem Cells in a Patient with Methanol-Induced Blindness.	26665934
Abnormal vision	Stem Cell Exhaustion	A 22-year-old male patient with bilateral visual loss at discharge after treatment for methanol ingestion was treated with retrobulbar and intrathecal autologus bone marrow derived stem cells in an outpatient setting.	26665934
Acute myocardial infarction	Stem Cell Exhaustion	Few data are available regarding the relation of left ventricular (LV) mechanical dyssynchrony to remodelling after acute myocardial infarction (MI) and stem cell therapy.	26666236
Relapsing course, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Relapsed or refractory diffuse large B-cell lymphoma (DLBCL) not suitable for high dose chemotherapy with autologous stem cell transplantation (ASCT) has a dismal prognosis and no standard therapy.	26666433
Aplastic Anemia, Lymphoproliferative Disorders	Stem Cell Exhaustion	Successful Allogeneic Stem Cell Transplantation for Severe Aplastic Anemia after Treatment of Lymphoproliferative Disorder Caused by Rabbit Antithymocyte Globulin.	26666612
Aplastic Anemia, CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology	Stem Cell Exhaustion	Immunosuppressive therapy (IST) with a combination of antithymocyte globulin (ATG) and cyclosporine (CsA) is an effective therapeutic modality for patients with aplastic anemia (AA) who are not eligible for allogeneic stem cell transplantation (Allo-SCT) from a human leukocyte antigen-identical sibling donor.	26666612
Malnutrition	Stem Cell Exhaustion	nutritional status before hematopoietic stem cell transplantation (HSCT) affects prognosis: better nourished patients have shorter time to engraftment, while malnutrition is associated with increase of mortality rates, complications, medical costs, poor quality of life and hospitalization stay.	26667746
Communicable Diseases	Stem Cell Exhaustion	An allogeneic hematopoietic stem cell transplantation (allo-HSCT)-stratified analysis revealed that the effect observed for the IL4Rrs2107356 and IFNgrs2069705 SNPs was stronger in allo-HSCT (IL4Rrs2107356 OR, 5.63; 95% CI, 1.20 to 3.09; IFNgrs2069705 OR, 0.24; 95% CI, 0.10 to 0.59) than in non-HSCT patients, suggesting that the presence of these SNPs renders patients more vulnerable to infection, especially under severe and prolonged immunosuppressive conditions.	26667837
Graft-vs-Host Disease	Stem Cell Exhaustion	Predicted indirectly recognizable HLA epitopes (PIRCHE) computationally predict donor T-cell recognition of mismatched-HLA derived peptides following allogeneic haematopoietic stem-cell transplantation (allo-HSCT), as is evidenced by the correlation between presence of HLA-DPB1-derived PIRCHE and the occurrence of graft-vs.-host disease (GVHD).	26669207
Acute GVH disease	Stem Cell Exhaustion	A donor-specific epigenetic classifier for acute graft-versus-host disease severity in hematopoietic stem cell transplantation.	26669438
Venous Thrombosis, Autoimmune cytopenia, Hodgkin Disease, Communicable Diseases	Stem Cell Exhaustion	Successful management of multilineage autoimmune cytopenia complicated with severe infection and deep vein thrombosis in a patient with Hodgkin lymphoma post-autologous hematopoietic stem cell transplantation.	26670732
Crohn Disease	Stem Cell Exhaustion	Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease: A Randomized Clinical Trial.	26670970
Crohn Disease	Stem Cell Exhaustion	Case reports and series suggest hematopoietic stem cell transplantation (HSCT) may benefit some patients with Crohn disease.	26670970
Colorectal Carcinoma, Specialty Type - cancer, Cytogenetic Complete Response	Stem Cell Exhaustion	Lgr5 has recently been identified as a reliable biomarker of cancer stem cells (CSCs) in colorectal cancer (CRC); however, its prognostic value is still controversial.	26674601
Disease, Inflammation, Hypomyelination	Stem Cell Exhaustion	These findings should help to design novel therapeutic strategies combining immunomodulation and stem/progenitor cell-based therapy for disorders associating hypomyelination with inflammation as observed in PMD.	26676415
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Stem Cell Exhaustion	While no cure exists for PMD, experimental cell-based therapy in the dysmyelinated shiverer model suggested that human oligodendrocyte progenitor cells (hOPCs) or human neural precursor cells (hNPCs) are promising candidates to treat myelinopathies.	26676415
Colorectal Carcinoma	Stem Cell Exhaustion	HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer.	26678341
Specialty Type - cancer, Malignant tumor of colon, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	In colon cancer, HOXA5 is downregulated, and its re-expression induces loss of the cancer stem cell phenotype, preventing tumor progression and metastasis.	26678341
Neoplasms, Malignant tumor of colon, Specialty Type - cancer	Stem Cell Exhaustion	Tumor regression by HOXA5 induction can be triggered by retinoids, which represent tangible means to treat colon cancer by eliminating cancer stem cells.	26678341
Hematopoietic Neoplasms, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukemia (AML) is a group of heterogeneous hematopoietic malignancies sustained by leukemic stem cells (LSCs) that can resist treatment.	26678889
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Correlation of somatic mutations with outcome after FLAMSA-busulfan sequential conditioning and allogeneic stem cell transplantation in patients with myelodysplastic syndromes.	26680262
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment option for myelodysplastic syndromes (MDS).	26680262
Weight decreased	Stem Cell Exhaustion	Weight Loss and Decrease of Body Mass Index during Allogeneic Stem Cell Transplantation Are Common Events with Limited Clinical Impact.	26683031
Type 2	Stem Cell Exhaustion	Chondrogenic progenitor cells (CPCs) produced high levels of laminin-a1, laminin-a5, and nidogen-2 in their pericellular matrix, and laminin-a1 enhanced collagen type II and reduced collagen type I expression by cultured CPCs.	26683663
Filamentous fungus, Malignant Neoplasms	Stem Cell Exhaustion	Patients with suspected invasive mould disease were randomised in a 1:1 ratio using an interactive voice-web response system, stratified by geographical region, allogeneic haemopoietic stem cell transplantation, and active malignant disease at baseline, to receive isavuconazonium sulfate 372 mg (prodrug; equivalent to 200 mg isavuconazole; intravenously three times a day on days 1 and 2, then either intravenously or orally once daily) or voriconazole (6 mg/kg intravenously twice daily on day 1, 4 mg/kg intravenously twice daily on day 2, then intravenously 4 mg/kg twice daily or orally 200 mg twice daily from day 3 onwards).	26684607
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Cyclophosphamide plus intravenous busulfan has not been compared with cyclophosphamide plus total body irradiation (TBI) in adults with advanced refractory acute myeloid leukaemia before allogeneic haemopoietic stem-cell transplantation (HCT).	26685771
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Post-remission treatment with allogeneic stem cell transplantation in patients aged 60 years and older with acute myeloid leukaemia: a time-dependent analysis.	26686044
Keratitis, Herpetic, Keratopathy, Keratitis, herpesvirus 3, human	Stem Cell Exhaustion	Patients were excluded who had coexisting potential causes for dendritiform keratopathy, such as prior herpes simplex keratitis, varicella-zoster viral keratitis, the linear form of Thygeson's superficial keratitis, epithelial regeneration line, Acanthamoeba keratitis, mucus plaque keratopathy, medication-related keratopathy, or limbal stem cell deficiency characterized by conjunctivalization of the corneal epithelium.	26686962
Conjunctival congestion, Corneal Opacity	Stem Cell Exhaustion	The parameters evaluated were the best-corrected visual acuity (BCVA), Schirmer test, tear film breakup time (TBUT), conjunctival congestion, corneal haze, vascularization, conjunctivalization, and limbal stem cell involvement.	26686968
Corneal Opacity	Stem Cell Exhaustion	No case in the AMT group demonstrated corneal haze, limbal stem cell deficiency, symblepharon, ankyloblepharon, or lid-related complications.	26686968
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GVHD) is the major cause of non-relapse mortality after allogeneic haemopoietic stem-cell transplantation (SCT).	26687425
Neoplasm Metastasis, Childhood Breast Carcinoma	Stem Cell Exhaustion	Breast cancer stem cells (BCSCs) play essential roles in tumor metastasis and contribute to remarkably negative clinical outcomes.	26687806
Cessation of life, Neoplasm Metastasis	Stem Cell Exhaustion	The most common causes of death were progression to advanced disease stage, including complications of stem-cell transplantation (17 [4%] patients), secondary malignancies (nine [2%] patients), and cardiovascular causes (nine [2%] patients).	26688093
Prostate carcinoma	Stem Cell Exhaustion	Characterization of reactive stroma in prostate cancer: involvement of growth factors, metalloproteinase matrix, sexual hormones receptors and prostatic stem cells.	26689510
Prostate carcinoma, Passive Cutaneous Anaphylaxis, Malignant neoplasm of prostate	Stem Cell Exhaustion	The objectives of the present study were to stablish a relationship of the RStr microenvironment with prostate cancer (Pca) through a morphological and molecular characterization, and to identify a possible relationship between RStr with worse prognosis factors and occurrence of malignant prostatic stem cells.	26689510
Passive Cutaneous Anaphylaxis	Stem Cell Exhaustion	It can be concluded that RStr may be a predictive marker of Pca progression, since it was associated with increase of growth factors, imbalance of androgen and estrogen receptors and presence of malign prostatic stem cells.	26689510
Metabolic Syndrome X	Stem Cell Exhaustion	Impact of a lifestyle modification program on the metabolic syndrome and associated risk factors in long-term survivors of stem cell transplantation.	26691422
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Despite survival improvement with novel agents and use of autologous hematopoietic stem cell transplantation (HSCT), cure of patients with multiple myeloma (MM) remains anecdotal.	26691426
Disseminated neuroblastoma	Stem Cell Exhaustion	Cord blood may be a feasible alternative stem cell source for auto-SCT in patients with stage 4 neuroblastoma, and outcomes may be improved compared to autologous PBSC or BM transplants.	26694195
Diabetes	Stem Cell Exhaustion	Acute Effects of Linagliptin on Progenitor Cells, Monocyte Phenotypes, and Soluble Mediators in Type 2 Diabetes.	26695864
Complications of Diabetes Mellitus	Stem Cell Exhaustion	Circulating cells, including endothelial progenitor cells (EPCs) and monocyte subtypes, are involved in diabetic complications.	26695864
Chronic Kidney Diseases	Stem Cell Exhaustion	The effects of linagliptin on progenitor cells and monocyte subtypes were similar in patients with or without CKD.	26695864
Specialty Type - cancer	Stem Cell Exhaustion	Correlation between expressions of stem cell-related molecules (ALDH-1, Notch 1, CD44) and epithelial-mesenchymal transition-related molecules (E-cadherin, S100A4) in cancer cells within VI and RFS was also analyzed.	26696594
Hypertrophic Cardiomyopathy	Stem Cell Exhaustion	Endothelial progenitor cells as markers of severity in hypertrophic cardiomyopathy.	26696595
Lymphoma, leukemia	Stem Cell Exhaustion	Consultations were recorded with 10 POs and 66 adolescents, aged 12-20 years, treated for leukemia (72.7%) or lymphoma (21.2%), or who had received hematopoietic stem-cell transplantation for a benign disease (7.6%).	26697269
Cataract	Stem Cell Exhaustion	Outcome of cataract surgery following simple limbal epithelial transplantation for lime injury-induced limbal stem cell deficiency.	26698204
Burn, CTCAE	Stem Cell Exhaustion	A 19-year-old woman presented to us after being diagnosed elsewhere with right eye total limbal stem cell deficiency resulting from a lime burn.	26698204
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	The Stat3/5 Signaling Biosignature in Hematopoietic Stem/Progenitor Cells Predicts Response and Outcome in Myelodysplastic Syndrome Patients Treated with Azacitidine.	26700206
Specialty Type - cancer	Stem Cell Exhaustion	Analysis of human tissue and human hepatic tumor cells in vitro revealed cells that express LPAR3 (HCC-NTL margin in vivo and SKHep1 in vitro) also express cancer stem cell markers in the absence of hepatocyte markers.	26701886
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	These data suggest cells that stain positive for both LPAR3 and cancer stem cell markers are distinct from the tumor mass per se, and may mediate tumor invasiveness/expansion via LPA-LPAR3 signaling.	26701886
Malignant neoplasm of liver	Stem Cell Exhaustion	Expression and function of lysophosphatidic acid receptors (LPARs) 1 and 3 in human hepatic cancer progenitor cells.	26701886
Glioblastoma Multiforme Pathway, Neoplasms	Stem Cell Exhaustion	These findings suggest that miR-21 is linked to glioma angiogenesis, that miR-21 is unlikely to regulate PTEN, and that miR-21-positive tumor cells do not possess stem cell characteristics.	26701969
Autoimmune reaction, Acquired aplastic anemia	Stem Cell Exhaustion	Acquired aplastic anemia (aAA) results from the T cell-mediated autoimmune destruction of hematopoietic stem cells.	26702937
Amyloidosis	Stem Cell Exhaustion	High-dose melphalan and autologous stem cell transplantation for systemic light-chain amyloidosis: a single institution retrospective analysis of 40 cases.	26703787
Amyloidosis	Stem Cell Exhaustion	We report our retrospective analysis of 40 patients who received high-dose melphalan and autologous stem cell transplantation for systemic immunoglobulin light-chain (AL) amyloidosis.	26703787
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cell markers have become a major research focus because of their relationship with radiation or chemotherapy resistance in cancer therapy.	26706028
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cell markers including OCT4 and SOX2 have been found in various solid tumors.	26706028
Hypoxic-Ischemic Encephalopathy	Stem Cell Exhaustion	Transplantation of placenta-derived mesenchymal stem cells reduces hypoxic-ischemic brain damage in rats by ameliorating the inflammatory response.	26707403
Development International Birth Date	Stem Cell Exhaustion	The purpose of our research was to explore the immunoregulatory mechanism of placenta-derived mesenchymal stem cells (PD-MSCs) in HIBD treatment.	26707403
Primary Myelofibrosis	Stem Cell Exhaustion	Cytokine Expression Pattern in Bone Marrow Microenvironment after Allogeneic Stem Cell Transplantation in Primary Myelofibrosis.	26708839
Primary Myelofibrosis, PMF Regimen	Stem Cell Exhaustion	The only curative therapy for primary myelofibrosis (PMF) is allogeneic stem cell transplantation (ASCT).	26708839
Acute myocardial infarction	Stem Cell Exhaustion	In animal models, G-CSF based progenitor cell mobilization combined with a DPP4 inhibitor leads to increased homing of bone marrow derived progenitor cells to the injured myocardium via the SDF1/CXCR4 axis resulting in improved ejection fraction and survival after acute myocardial infarction (AMI).	26709136
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Progenitor cell therapy comprising the use of G-CSF and Sitagliptin after successfully revascularized acute myocardial infarction fails to show a beneficial effect on cardiac function and clinical events after 12 months.	26709136
Hematologic Neoplasms	Stem Cell Exhaustion	This analysis compared duration of RV shedding as detected by culture and PCR among patients in a high-risk oncology setting (adult patients with haematological malignancy and/or stem cell transplant and all paediatric oncology patients) and determined risk factors for extended shedding.	26711433
Rheumatoid Arthritis, Degenerative polyarthritis	Stem Cell Exhaustion	Adipose-derived mesenchymal stem cells from infrapatellar fat pad of patients with rheumatoid arthritis and osteoarthritis have comparable immunomodulatory properties.	26711868
Mycoses	Stem Cell Exhaustion	Incidence and characteristics of invasive fungal diseases in allogeneic hematopoietic stem cell transplant recipients: a retrospective cohort study.	26715563
Mycoses	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplant (HSCT) recipients experience an increased risk for invasive fungal diseases (IFDs).	26715563
Malignant neoplasm of stomach, Krukenberg Tumor	Stem Cell Exhaustion	Isolation and comparison of mesenchymal stem cell-like cells derived from human gastric cancer tissues and corresponding ovarian metastases.	26718033
Neoplasms	Stem Cell Exhaustion	Mesenchymal stem cell (MSC)-like cells have been isolated from various types of tumor.	26718033
Inflammation, Autoimmune state, Atherosclerosis, Malignant Peripheral Nerve Sheath Tumor	Stem Cell Exhaustion	It is discussed if chronic inflammation in relation to autoimmunity and atherosclerosis might elicit mutations in the hematopoietic stem cell resulting in MPNs, or whether this association actually reflects a long-lasting pre-MPN-diagnosis phase, in which the MPN-disease per se contributes to a chronic inflammatory state and immune deregulation.	26718091
Childhood Breast Carcinoma	Stem Cell Exhaustion	Tripartite motif 16 suppresses breast cancer stem cell properties through regulation of Gli-1 degradation via the ubiquitin-proteasome pathway.	26718507
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells (CSCs) are responsible for cancer progression and patient prognosis.	26718507
Purpura, Thrombotic Thrombocytopenic	Stem Cell Exhaustion	Baseline CECs and circulating endothelial progenitor cells showed marginal associations with TTP.	26721701
Specialty Type - cancer, Neoplasms, Vascular Tissue	Stem Cell Exhaustion	Expression of cancer stem cell markers and their correlation with pathogenesis in vascular tumors.	26722452
Specialty Type - cancer, Neoplasms, Vascular Tissue	Stem Cell Exhaustion	Thus the purpose of this study was to explore whether different expression level of cancer stem cell markers including CD29, CD44, CD133, nestin and ALDH1 in vascular tumor may help to elucidate the possible pathogenesis of vascular tumor.	26722452
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Previous studies have reported an association of cancer stem cells with the development of tumor in many solid tumors.	26722452
Specialty Type - cancer, Neoplasms, Vascular Tissue	Stem Cell Exhaustion	Our findings confirmed that the five cancer stem cells markers, including CD29, CD44, CD133, nestin and ALDH1, exhibited different expression levels in vascular tumors and demonstrated that immunohistochemical analysis for cancer stem cells markers may provide useful information for studying the pathogenesis of vascular tumors.	26722452
Gastrointestinal Stromal Tumors, Neoplasms	Stem Cell Exhaustion	Gastrointestinal stromal tumor is the most common stromal tumor, which is usually considered as originating from Cajal cells in the gastrointestinal tract or mesenchymal stem cells with the mutation of KIT or PDGFRA gene.	26722567
Childhood Breast Carcinoma	Stem Cell Exhaustion	High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation as Adjuvant Treatment in High-Risk Breast Cancer: Data from the European Group for Blood and Marrow Transplantation Registry.	26723932
Best Case Imputation Technique, Toxic effect, Childhood Breast Carcinoma	Stem Cell Exhaustion	The aim of this retrospective study was to assess toxicity and efficacy of adjuvant high-dose chemotherapy (HDC) and autologous hematopoietic stem cell transplantation (AHSCT) in 583 high-risk breast cancer (BC) patients (>3 positive nodes) who were transplanted between 1995 and 2005 in Europe.	26723932
Central Diabetes Insipidus	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) confers increased risk for CDI because of prolonged hospital stay, immunosuppression, the need to use broad-spectrum antibiotics and a complex interplay of preparative regimen and GvHD-induced gut mucosal damage.	26726944
Alport Syndrome	Stem Cell Exhaustion	Human Chorionic Stem Cells: Podocyte Differentiation and Potential for the Treatment of Alport Syndrome.	26728561
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	Chemoimmunotherapy followed by autologous stem cell transplantation (ASCT) is a standard therapy for transplant-eligible patients with newly diagnosed mantle cell lymphoma (MCL).	26729345
Graft-vs-Host Disease, Lymphoma	Stem Cell Exhaustion	The addition of sirolimus to the graft-versus-host disease prophylaxis regimen in reduced intensity allogeneic stem cell transplantation for lymphoma: a multicentre randomized trial.	26729448
Graft-vs-Host Disease	Stem Cell Exhaustion	The mTOR inhibitor sirolimus has been used in the prevention and treatment of graft-versus-host disease (GVHD) after allogeneic haematopoietic stem cell transplantation (HSCT).	26729448
Endometrial Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Progestin treatment decreases CD133+ cancer stem cell populations in endometrial cancer.	26731726
Endometrial Carcinoma	Stem Cell Exhaustion	CD133 is a marker of endometrial cancer stem cells.	26731726
Liver carcinoma, Experimental Organism Malignant Hepatocholangiocellular Carcinoma, Malignant neoplasm of liver	Stem Cell Exhaustion	Clinicopathologic Characteristics of Hepatocellular Carcinoma With Reactive Ductule-like Components, a Subset of Liver Cancer Currently Classified as Combined Hepatocellular-Cholangiocarcinoma With Stem-Cell Features, Typical Subtype.	26735856
Liver carcinoma, Carcinogenic Chlorinated Hydrocarbon, Experimental Organism Malignant Hepatocholangiocellular Carcinoma	Stem Cell Exhaustion	The aim of this study was to elucidate the clinicopathologic characteristics of hepatocellular carcinoma with reactive ductule-like components (HCC-RD), corresponding to combined hepatocellular-cholangiocarcinoma (CHC) with stem cell features, typical subtype.	26735856
Sarcopenia	Stem Cell Exhaustion	As autophagy also declines in human geriatric satellite cells, our findings reveal autophagy to be a decisive stem-cell-fate regulator, with implications for fostering muscle regeneration in sarcopenia.	26738589
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We first quantified RBM38 and DND1 mRNA expression in clinical AML patient samples and CD34(+) progenitor cells and mature granulocytes from healthy donors.	26740055
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We found significantly lower RBM38 and DND1 mRNA levels in AML blasts and CD34(+) progenitor cells as compared to mature neutrophils from healthy donors.	26740055
Specialty Type - cancer	Stem Cell Exhaustion	Long-Term Follow-Up of Allogeneic Hematopoietic Stem Cell Transplantation for Solid Cancer.	26740375
Specialty Type - cancer	Stem Cell Exhaustion	We wanted to determine whether allogeneic hematopoietic stem cell transplantation (HSCT) may result in long-term survival in patients with solid cancer.	26740375
Hemorrhagic cystitis	Stem Cell Exhaustion	Hemorrhagic Cystitis Requiring Bladder Irrigation is Associated with Poor Mortality in Hospitalized Stem Cell Transplant Patients.	26742970
Hematuria, CTCAE	Stem Cell Exhaustion	To evaluate the overall prognosis of post-stem cell transplant inpatients who required continuous bladder irrigation (CBI) for hematuria.	26742970
Hemorrhagic cystitis	Stem Cell Exhaustion	We performed a retrospective analysis of adult stem cell transplant recipients who received CBI for de novo hemorrhagic cystitis as inpatients on the bone marrow transplant service at Washington University from 2011-2013.	26742970
cobalt-factor II C20-methyltransferase activity, Systemic disease, Hemorrhagic cystitis	Stem Cell Exhaustion	Hemorrhagic cystitis requiring CBI is a symptom of severe systemic disease in stem cell transplant patients.	26742970
Malignant Neoplasms	Stem Cell Exhaustion	The goal of this study was to determine whether single nucleotide polymorphisms (SNPs) in genes involved in gemcitabine metabolism, DNA damage repair, multidrug resistance, and alkylator detoxification influence the clinical outcome of patients with refractory/relapsed lymphoid malignancies receiving high-dose gemcitabine/busulfan/melphalan (Gem/Bu/Mel) with autologous stem cell support.	26743341
Hyperpyrexia	Stem Cell Exhaustion	Rapid diagnosis of Propionibacterium acnes infection in patient with hyperpyrexia after hematopoietic stem cell transplantation by next-generation sequencing: a case report.	26743541
Juvenile Myelomonocytic Leukemia, Exanthema, Hyperpyrexia	Stem Cell Exhaustion	After haploidentical hematopoietic stem cell transplantation, a two-year-old boy with juvenile myelomonocytic leukemia presented to a pediatrist in a medical facility with hyperpyrexia and red skin rash which later changed to black skin rash all over his body.	26743541
Alzheimers Disease	Stem Cell Exhaustion	Human Cortical Neural Stem Cells Expressing Insulin-Like Growth Factor-I: A Novel Cellular Therapy for Alzheimer's Disease.	26744412
Amyotrophic Lateral Sclerosis, Inflammation, Pathology	Stem Cell Exhaustion	In amyotrophic lateral sclerosis, we have shown that transplanted spinal neural stem cells (NSCs) integrate into the spinal cord, form synapses with the host, improve inflammation, and reduce disease-associated pathologies.	26744412
Microvascular Angina, Erectile dysfunction, Diabetes Mellitus, Hypertension, CTCAE	Stem Cell Exhaustion	Stem cell therapy is thought to improve wound healing and promote vasculogenesis and has also been investigated as a treatment for patients with erectile dysfunction (ED), which is usually caused by a microvascular disease such as diabetes mellitus or hypertension.	26745574
Erectile dysfunction	Stem Cell Exhaustion	Determining the Feasibility of Managing Erectile Dysfunction in Humans With Placental-Derived Stem Cells.	26745574
leukemia	Stem Cell Exhaustion	Naive Donor NK Cell Repertoires Associated with Less Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation.	26746188
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	The impact of advances in supportive care and hematopoietic stem cell transplantation (HSCT) practices on the outcomes of patients who develop grade III or IV acute graft-versus-host disease (GVHD) is unknown.	26748160
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Successful reduced-intensity stem cell transplantation for GATA2 deficiency before progression of advanced MDS.	26748574
Hematologic Neoplasms, Vancomycin-Resistant Enterococci, Colonization	Stem Cell Exhaustion	OBJECTIVE To study the effect of discontinuation of systematic surveillance for vancomycin-resistant Enterococcus (VRE) and contact isolation of colonized patients on the incidence of VRE bacteremia SETTING A hematology-oncology unit with high prevalence of VRE colonization characterized by predominantly sporadic molecular epidemiology PARTICIPANTS Inpatients with hematologic malignancies and recipients of hematopoietic stem cell transplantation METHODS The incidence of VRE bacteremia was measured prospectively during 2 different 3-year time periods; the first during active VRE surveillance and contact precautions and the second after discontinuation of these policies.	26750087
Hematologic Neoplasms, Vancomycin-Resistant Enterococci, Colonization	Stem Cell Exhaustion	CONCLUSION Active surveillance and contact precautions for VRE colonization did not appear to prevent VRE bacteremia in patients with hematologic malignancies and recipients of hematopoietic stem cell transplantation with high prevalence of VRE characterized by predominantly sporadic molecular epidemiology.	26750087
Neoplasms	Stem Cell Exhaustion	Spalt-like transcription factor 4 (SALL4) is a transcription factor which is able to regulate development and embryonic stem cell pluripotency, and it is also involved in some tumor progression.	26750614
Thalassemia	Stem Cell Exhaustion	Hemopoietic stem cell transplantation in thalassemia: a report from the European Society for Blood and Bone Marrow Transplantation Hemoglobinopathy Registry, 2000-2010.	26752139
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Durable responses to ibrutinib in patients with relapsed CLL after allogeneic stem cell transplantation.	26752141
Cessation of life	Stem Cell Exhaustion	Analysis of non-relapse mortality and causes of death over 15 years following allogeneic hematopoietic stem cell transplantation.	26752142
Hematologic Neoplasms	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has curative potential against hematological malignancies.	26752142
Alzheimers Disease	Stem Cell Exhaustion	Distribution of human umbilical cord blood-derived mesenchymal stem cells in the Alzheimer's disease transgenic mouse after a single intravenous injection.	26752148
Alzheimers Disease	Stem Cell Exhaustion	The aim of this study was to track the migration of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) administered through a single intravenous injection and to observe the consequential therapeutic effects in a transgenic Alzheimer's disease mouse model.	26752148
Inflammation	Stem Cell Exhaustion	Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation.	26752157
Graft-vs-Host Disease, Leukemia, Myelomonocytic, Chronic	Stem Cell Exhaustion	Impacts of graft-versus-host disease on outcomes after allogeneic hematopoietic stem cell transplantation for chronic myelomonocytic leukemia: A nationwide retrospective study.	26754557
Leukemia, Myelomonocytic, Chronic	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a therapeutic option that may lead to improved outcomes in patients with chronic myelomonocytic leukemia (CMML).	26754557
Glioblastoma Multiforme Pathway, Glioma, Neoplasms, Malignant Glioma	Stem Cell Exhaustion	Immunohistochemistry and flow cytometry analysis of 12 tumor samples obtained from patients with high grade gliomas revealed that a considerable population (2-19%) of cells in all malignant gliomas expressed IL-17RA, with remarkable co-expression of the glioma stem cell (GSC) markers CD133, Nestin, and Sox2.	26755664
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Preferential expression of functional IL-17R in glioma stem cells: potential role in self-renewal.	26755664
Malignant neoplasm of larynx, Specialty Type - cancer	Stem Cell Exhaustion	The soluble fraction of the CD44 protein (solCD44) may constitute a valuable biological marker of Cancer Stem Cells (CSCs), useful for screening/early detection of laryngeal cancer, and for the prognosis.	26756618
Diabetes, leukemia	Stem Cell Exhaustion	Survivors of childhood leukaemia treated with haematopoietic stem cell transplantation and total body irradiation should undergo screening for diabetes by oral glucose tolerance tests.	26757409
Diabetes, Specialty Type - cancer, Impaired T cell function	Stem Cell Exhaustion	Childhood cancer survivors treated with haematopoietic stem cell transplantation (HSCT) and total body irradiation are at an increased risk of developing diabetes early in life due to insulin resistance and b-cell dysfunction, but the optimal screening method is unknown.	26757409
Anemia, Sickle Cell	Stem Cell Exhaustion	Improved Splenic Function After Hematopoietic Stem Cell Transplant for Sickle Cell Disease.	26757445
Renal carnitine transport defect	Stem Cell Exhaustion	Hematopoietic stem cell transplant (HSCT) is a proven cure for SCD; however, its long-term effect on splenic function is not well characterized.	26757445
Malignant Glioma	Stem Cell Exhaustion	Prognostic significance of stem cell marker CD133 determined by promoter methylation but not by immunohistochemical expression in malignant gliomas.	26757925
Neoplasms	Stem Cell Exhaustion	CD133 has played a pivotal role in the identification and isolation of brain tumor stem cells.	26757925
Myeloma cell	Stem Cell Exhaustion	Fractionated stem cell infusions for patients with plasma cell myeloma undergoing autologous hematopoietic cell transplantation.	26758672
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The correlation of TIGIT expression to clinical outcomes, including rate of complete remission and relapse post-allogeneic stem cell transplantation (alloSCT) in AML patients, was analyzed.	26763253
Myeloid neoplasm	Stem Cell Exhaustion	Loss-of-function of ten-eleven translocation-2 (TET2) is a common event in myeloid malignancies, and plays pleiotropic roles, including augmenting stem cell self-renewal and skewing hematopoietic cells to the myeloid lineage.	26763362
adult nasal type extranodal NK/T-cell lymphoma	Stem Cell Exhaustion	Intraocular Relapse with Hypopyon and Retinal Infiltrates after Chemotherapy and Peripheral Blood Stem Cell Transplantation for Extranodal NK/T-Cell Lymphoma.	26763364
Lymphoma, Intraocular Route of Drug Administration	Stem Cell Exhaustion	In conclusion, we report a case of NK/T-cell lymphoma relapse with intraocular lesions, after combined chemotherapy and hematopoietic stem cell transplantation.	26763364
Autoimmune Diseases, Acquired aplastic anemia	Stem Cell Exhaustion	Memory Stem T Cells in Autoimmune Disease: High Frequency of Circulating CD8+ Memory Stem Cells in Acquired Aplastic Anemia.	26764034
T-Cell Large Granular Lymphocyte, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Four patients with associated myelodysplastic syndrome and two who had received haemopoietic stem cell transplantation had either no response or were not evaluable, meaning 14 (74% [49-91]) of the 19 patients with classic T-LGL responded.	26765645
Hematologic Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	In order to further explore the relationship between CD34(+)cell dose and total nucleated cell dose on reduced-intensity transplant outcomes, we analyzed the effect of donor graft dose and composition on outcomes of 705 patients with hematologic malignancies who underwent reduced-intensity peripheral blood stem cell transplantation at the Dana Farber Cancer Institute from 2000 to 2010.	26768686
HLA Mismatch, Acute GVH disease	Stem Cell Exhaustion	With regard to clinical implications, patient mismatched HLA-C*14:02 proved to be a potent risk factor for severe acute graft-versus-host disease and mortality, and should be considered a non-permissive HLA-C mismatch in donor selection for unrelated donor hematopoietic stem cell transplantation.	26768690
TAF1 wt Allele, X-linked inheritance	Stem Cell Exhaustion	Decreased N-TAF1 expression in X-linked dystonia-parkinsonism patient-specific neural stem cells.	26769797
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	TP53 mutation in patients with high-risk acute myeloid leukaemia treated with allogeneic haematopoietic stem cell transplantation.	26771088
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Here, we studied the impact of TP53 mutations on the outcome of AML patients with adverse cytogenetic risk treated with allogeneic haematopoietic stem cell transplantation (HSCT).	26771088
histiocytic	Stem Cell Exhaustion	Based on DC induction from hematopoietic stem cells, myeloid progenitors, and monocytes, and occasional expressions of histocyte-related antigens (HRAs) in M5, we presume some M5 cases share histiocytic phenotypes originally.	26771450
Neoplasms	Stem Cell Exhaustion	Telomerase activity controls telomere length, and this plays an important role in stem cells, aging and tumors.	26771767
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	These results suggest that LC3 suppresses TNBC in mature tumor cells and cancer stem cells (CSCs).	26772398
Neoplasms, Fibroepithelial	Stem Cell Exhaustion	The stem cell renewal and DNA damage response pathways are frequently altered in fibroepithelial tumors of breast in Indian patients.	26774289
Multiple Myeloma	Stem Cell Exhaustion	Phagocyte function decreases after high-dose treatment with melphalan and autologous stem cell transplantation in patients with multiple myeloma.	26774385
Multiple Myeloma	Stem Cell Exhaustion	High-dose melphalan with autologous hematopoietic stem cell transplantation (ASCT) is the standard of care for younger patients with newly diagnosed multiple myeloma and is aimed at achieving as deep and complete a response as possible after various combinations of induction therapy.	26774385
Cerebrovascular accident	Stem Cell Exhaustion	Mobilization of Circulating Endothelial Progenitor Cells by dl-3-n-Butylphthalide in Acute Ischemic Stroke Patients.	26775268
Ischemic stroke	Stem Cell Exhaustion	The research aim was to investigate the effects of dl-3-n-butylphthalide (NBP) on the level of circulating endothelial progenitor cells (EPCs) and clinical outcome in patients with acute ischemic stroke (AIS).	26775268
Glioblastoma Multiforme Pathway, Neoplasms	Stem Cell Exhaustion	Senescence from glioma stem cell differentiation promotes tumor growth.	26775840
Glioblastoma Multiforme Pathway, Adult Glioblastoma, Neoplasms	Stem Cell Exhaustion	Glioblastoma (GBM) is a lethal brain tumor composed of heterogeneous cellular populations including glioma stem cells (GSCs) and differentiated non-stem glioma cells (NSGCs).	26775840
Specialty Type - cancer, Ulcerative Colitis	Stem Cell Exhaustion	Sulfasalazine reduces the risk of ulcerative colitis (UC)-related cancer through its anti-inflammatory effect and induction of oxidative stress in cancer cells by inhibiting the glutamate-cystine transporter, which is closely associated with the cancer stem cell surface marker CD44v9.	26775891
Specialty Type - cancer, Ulcerative Colitis	Stem Cell Exhaustion	Sulfasalazine, a therapeutic agent for ulcerative colitis, inhibits the growth of CD44v9(+) cancer stem cells in ulcerative colitis-related cancer.	26775891
Complications of Diabetes Mellitus	Stem Cell Exhaustion	Adipose-derived stem cells (ASCs) represent an important source of cell therapy to treat diabetic complications.	26780864
Malignant neoplasm of lung, Specialty Type - cancer	Stem Cell Exhaustion	SOX2 signaling is important in maintaining the stem cell-like phenotype of cancer cells and contributes to the pathogenesis of lung cancer.	26780934
Decreased platelet count	Stem Cell Exhaustion	Bacterial Pneumonia-induced Persistent Remission of Severe Immune Thrombocytopenia after Allogeneic Hematopoietic Stem Cell Transplantation.	26781020
Allogeneic Hematopoietic Stem Cell Transplantation, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	A 53-year-old woman with chronic myeloid leukemia received allogeneic hematopoietic stem cell transplantation.	26781020
Limbal stem cell deficiency	Stem Cell Exhaustion	This is a case report of a 50-year-old patient presenting with unilateral limbal stem-cell deficiency who was referred for autologous limbal stem-cell transplant.	26783982
Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8, diabetic	Stem Cell Exhaustion	We reasoned that coupling hematopoietic stem cells (HSCs) transplantation with ex vivo transduction of syngeneic HSCs with lentiviral vectors to express proinsulin II could prevent T1D in nonobese diabetic (NOD) mice.	26784909
Lymphoma, Follicular	Stem Cell Exhaustion	The role of autologous stem cell transplantation (ASCT) in patients with relapsed follicular lymphoma (FL) remains controversial because of a lack of proven overall survival (OS) benefit versus nontransplant strategies.	26785331
Prostate carcinoma	Stem Cell Exhaustion	The role of mesenchymal stem cells in promoting the transformation of androgen-dependent human prostate cancer cells into androgen-independent manner.	26787499
Prostate carcinoma, Passive Cutaneous Anaphylaxis	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) play an important role in the development of human prostate cancer (PCa).	26787499
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In acute myeloid leukemia (AML), alloreactive natural killer (NK) cells are crucial mediators of immune responses after haploidentical stem cell transplantation.	26787753
Diabetes	Stem Cell Exhaustion	In recent years, stem cell transplant has led to treatment of various diseases including diabetes.	26788941
Transitional Meningioma, diabetic	Stem Cell Exhaustion	We sought to report a type 1 diabetic patient with a brain mass, diagnosed as transitional meningioma, after a fetal hematopoietic stem cell transplant.	26788941
Diabetes Mellitus, Insulin-Dependent, Hemopoietic stem cell transplant, Nausea, Headache, Have Been Vomiting, Visual disturbance	Stem Cell Exhaustion	A 57-year-old woman with type 1 diabetes who previously had undergone a fetal hematopoietic stem cell transplant, attended the clinic with a history of progressive bifrontal headaches accompanied by nausea, vomiting, and visual disturbances over the previous 8 months.	26788941
Transitional Meningioma	Stem Cell Exhaustion	To our knowledge, this is the first report of transitional meningioma as a result of stem cell transplant.	26788941
Diabetes Mellitus, Insulin-Dependent	Stem Cell Exhaustion	Despite all unanswered questions about the safety of stem cell transplant, this novel therapy provides hope for patients with type 1 diabetes.	26788941
Transitional Meningioma	Stem Cell Exhaustion	The results indicated transitional meningioma with the origin of transplanted fetal hematopoietic stem cells.	26788941
Neoplasms	Stem Cell Exhaustion	Our data indicates that ESRD/ACRD is a novel disease and the inflammatory microenvironment altered plasticity, and stem cell characteristics of epithelial cells may be associated with the high risk of tumor development.	26790439
Acute myocardial infarction	Stem Cell Exhaustion	Stem cell mobilisation by granulocyte-colony stimulating factor in patients with acute myocardial infarction.	26790705
Infarction, Acute myocardial infarction, Coronary Restenosis	Stem Cell Exhaustion	In the REVIVAL-2 study we found that stem cell mobilisation by G-CSF does not influence infarct size, left ventricular function and coronary restenosis in patients with acute myocardial infarction (MI) that underwent successful percutaneous coronary intervention.	26790705
Paralysed, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	One patient suffered from transient paralysis following stem cell transplant for treatment of myelodysplastic syndrome.	26791929
Gastrointestinal mucositis	Stem Cell Exhaustion	Reactivation of polyomavirus in the genitourinary tract is significantly associated with severe GvHD and oral mucositis following allogeneic stem cell transplantation.	26792012
Viruria, Hemorrhagic cystitis	Stem Cell Exhaustion	Hemorrhagic cystitis and symptomatic viruria caused by these viruses are a major cause of morbidity in patients undergoing allogeneic stem cell transplantation.	26792012
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	We investigated the expression of the progenitor/stem cell markers GD3 ganglioside and NG2 proteoglycan in GBM, peritumor tissue (brain adjacent to tumor, BAT) and cancer stem-like cells (CSCs) isolated from GBM (GCSCs) and BAT (PCSCs).	26792897
Neoplasms	Stem Cell Exhaustion	Moreover, only transduced cultures originating from cultures bearing stem cells induce tumors in nude mice.	26795563
Neoplasms	Stem Cell Exhaustion	Importantly, high sHLA-GEV levels before NACT were related to disease progression and the detection of stem cell-like circulating tumor cells, but high sHLA-Gfree levels indicated an improved clinical outcome.	26796737
Malignant Neoplasms	Stem Cell Exhaustion	The non-classical human leukocyte antigen G (HLA-G) molecule and its soluble forms exert multiple immune suppressive regulatory functions in malignancy and in stem cells contributing to immune escape mechanisms.	26796737
Aplastic Anemia	Stem Cell Exhaustion	Bone marrow (BM) is the preferred graft source for hematopoietic stem cell transplantation (HSCT) in severe aplastic anemia (SAA) compared with mobilized peripheral blood stem cells (PBSCs).	26797402
Aplastic Anemia	Stem Cell Exhaustion	Comparing Outcomes with Bone Marrow or Peripheral Blood Stem Cells as Graft Source for Matched Sibling Transplants in Severe Aplastic Anemia across Different Economic Regions.	26797402
Multiple Pregnancy	Stem Cell Exhaustion	Notch signalling regulates stem cell development and survival and is deregulated in multiple malignancies.	26798966
Specialty Type - cancer, Medullary carcinoma of thyroid	Stem Cell Exhaustion	Expression of the potential cancer stem cell markers CD133 and CD44 in medullary thyroid carcinoma: A ten-year follow-up and prognostic analysis.	26799258
Specialty Type - cancer, NTRK1 wt Allele, Medullary carcinoma of thyroid	Stem Cell Exhaustion	To investigate the expression profiles of cancer stem cells (CSCs) markers CD133 and CD44 in a cohort of medullary thyroid carcinoma (MTC) patients, and their prognostic values during 10-year follow-up.	26799258
Infection	Stem Cell Exhaustion	Allogeneic stem cell transplantation is potentially curative, but associated with post-transplantation complications, including cytomegalovirus (CMV) infections.	26800118
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	This study confirms the poor prognosis of de novo CD5+ DLBCL in a large multi-center cohort despite initial rituximab-containing chemotherapy and suggests that stem cell transplantation fails to salvage the majority of these patients.	26800311
Graft-vs-Host Disease	Stem Cell Exhaustion	A comparison of tacrolimus and cyclosporine combined with methotrexate for graft-versus-host disease prophylaxis, stratified by stem cell source: a retrospective nationwide survey.	26800676
leukemia	Stem Cell Exhaustion	Data were obtained from the Transplant Registry Unified Management Program of the Japan Society for Hematopoietic Cell Transplantation for >= 16-year-old leukemia patients who received CsA/MTX or TAC/MTX after bone marrow transplantation and peripheral blood stem cell transplantation from serological HLA-matched related donors (MRD), HLA 8/8 allele-matched, or one allele-mismatched unrelated bone marrow (UBM), or 0-2 antigen-mismatched unrelated cord blood (UCB) transplantation between January 2005 and December 2009.	26800676
Thalassemia	Stem Cell Exhaustion	Hematopoietic peripheral circulating blood stem cells as an independent marker of good transfusion management in patients with b-thalassemia: results from a preliminary study.	26801519
Thalassemia	Stem Cell Exhaustion	We investigated the levels of peripheral circulating CD34+ stem cells as an independent marker of appropriate hematopoietic balance in patients with thalassemia.	26801519
Hypothyroidism	Stem Cell Exhaustion	At multivariate analysis, peripheral circulating CD34+ stem cells did not correlate with age, sex, smoking habit, number of RBCs units transfused, Hb levels, iron chelation therapy, history of splenectomy, and hypothyroidism.	26801519
Thalassemia	Stem Cell Exhaustion	Circulating peripheral CD34 + stem cells are increased in b-thalassemia, in particular in nontransfused patients, compared to healthy controls.	26801519
Multiple Myeloma	Stem Cell Exhaustion	The combination of melphalan, prednisone, and thalidomide (MPT) is considered standard therapy for newly diagnosed patients with multiple myeloma who are ineligible for stem cell transplantation.	26802176
Chief complaint (finding)	Stem Cell Exhaustion	We analyzed, in a prospective monocentric study, three different endothelial biomarkers, endothelial microparticles (EMPs), endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) in 132 older patients who underwent a full evaluation of a memory complaint.	26803509
Respiratory Distress Syndrome, Newborn	Stem Cell Exhaustion	Epidemiology of Acute Respiratory Distress Syndrome Following Hematopoietic Stem Cell Transplantation.	26807683
Pulmonary Complication	Stem Cell Exhaustion	Pulmonary complications are common following hematopoietic stem cell transplantation.	26807683
Respiratory Distress Syndrome, Newborn	Stem Cell Exhaustion	Patients were screened for acute respiratory distress syndrome development within 1 year of hematopoietic stem cell transplantation.	26807683
Respiratory Distress Syndrome, Newborn	Stem Cell Exhaustion	In total, 133 cases of acute respiratory distress syndrome developed in 2,635 patients undergoing hematopoietic stem cell transplantation (5.0%).	26807683
Respiratory Distress Syndrome, Newborn	Stem Cell Exhaustion	Acute respiratory distress syndrome developed in 75 patients (15.6%) undergoing allogeneic hematopoietic stem cell transplantation and 58 patients (2.7%) undergoing autologous hematopoietic stem cell transplantation.	26807683
Respiratory Distress Syndrome, Newborn	Stem Cell Exhaustion	Median time to acute respiratory distress syndrome development was 55.4 days (interquartile range, 15.1-139 d) in allogeneic hematopoietic stem cell transplantation and 14.2 days (interquartile range, 10.5-124 d) in autologous hematopoietic stem cell transplantation.	26807683
Respiratory Distress Syndrome, Newborn	Stem Cell Exhaustion	At 12 months following hematopoietic stem cell transplantation, 89 patients (66.9%) who developed acute respiratory distress syndrome had died.	26807683
Respiratory Distress Syndrome, Newborn	Stem Cell Exhaustion	Acute respiratory distress syndrome is a frequent complication following hematopoietic stem cell transplantation, dramatically influencing patient-important outcomes.	26807683
Respiratory Distress Syndrome, Newborn, Hepatopulmonary Syndrome	Stem Cell Exhaustion	Most cases of acute respiratory distress syndrome following hematopoietic stem cell transplantation do not meet criteria for a more specific post-transplantation pulmonary syndrome.	26807683
Dry Eye Syndromes	Stem Cell Exhaustion	Dry Eye Disease Is Already Present in Hematological Patients Before Hematopoietic Stem Cell Transplantation.	26807906
Lymphoproliferative Disorders	Stem Cell Exhaustion	Tear film break-up time was found to be the only parameter statistically worse in the chronic lymphoproliferative disorder group compared with the stem cell malignancy group.	26807906
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Although allogeneic hematopoietic stem cell transplantation from an HLA-matched sibling donor (MSD) is a potentially curative post-remission treatment for adults with acute myeloid leukemia (AML) in their first CR, transplant-related morbidity and mortality remains a major drawback.	26808566
Ambiguity	Stem Cell Exhaustion	We retrospectively compared the outcomes of patients who underwent autologous peripheral blood stem cell transplantation (auto-PBSCT; n=375) with those who underwent allogeneic bone marrow transplantation (allo-BMT; n=521) and allo-PBSCT (n=380) from MSDs for adults with AML/CR1, in which propensity score models were used to adjust selection biases among patients, primary physicians and institutions to overcome ambiguity in the patients' background information.	26808566
Fibrosis Assessment, Dry Eye Syndromes	Stem Cell Exhaustion	After allogeneic hematopoietic stem cell transplantation (allo-SCT), ocular GvHD is a common complication, typical symptoms being dry eye syndrome with features of fibrosis.	26808567
Prediabetes syndrome	Stem Cell Exhaustion	Mechanisms of mesenchymal stem cell correction of the impaired biomechanical properties of diabetic skin: The role of miR-29a.	26808714
diabetic	Stem Cell Exhaustion	We further hypothesize that treatment with mesenchymal stem cells (MSCs) may improve diabetic wound healing by correction of the dysregulated miR-29a expression.	26808714
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Inhibition of Fatty Acid Synthase Decreases Expression of Stemness Markers in Glioma Stem Cells.	26808816
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	However, little is known about the significance of cellular lipid metabolism in the regulation of biological activity of glioma stem cells (GSCs).	26808816
Ki-1+ Anaplastic Large Cell Lymphoma, Anaplastic large B-cell lymphoma	Stem Cell Exhaustion	AE: adverse event; ALCL: anaplastic large cell lymphoma; ALK: anaplastic lymphoma kinase; ASCT: autologous stem cell transplant; BEAM: BCNU/carmustine, etoposide, ara-C, and melphalan; BV: brentuximab vedotin; CHEOP: cyclophosphamide, daunorubicin, vincristine, prednisone, etoposide; CHOP: cyclophosphamide, doxorubicin, vincristine, prednisone; CR:complete response; G3+: grade 3 or higher; MTD: maximum tolerated dose; ORR: overall response rate; OS: overall survival; PFS: progression-free survival.	26809026
Infection	Stem Cell Exhaustion	Infections with human b-herpesviruses are common worldwide and are still frequent in patients after hematopoietic stem cell transplantation.	26809130
Coinfection, Cytomegalovirus Infections	Stem Cell Exhaustion	The co-infection with these b-herpesviruses could predispose patients after hematopoietic stem cell transplantation to a longer and more severe CMV infection.	26809130
Nocardia Infections	Stem Cell Exhaustion	Nocardiosis following hematopoietic stem cell transplantation.	26809666
Hematologic Neoplasms, Nocardia Infections	Stem Cell Exhaustion	Patients with hematologic malignancies undergoing hematopoietic stem cell transplantation (HSCT) are at risk for nocardiosis, and further data in regard to characteristics of disease in this population are warranted.	26809666
Hemorrhagic cystitis	Stem Cell Exhaustion	Studies of human polyomaviruses, with HPyV7, BKPyV, and JCPyV present in urine of allogeneic hematopoietic stem cell transplanted patients with or without hemorrhagic cystitis.	26809742
CLTC gene, Hemorrhagic cystitis, Nephritis, Leukoencephalopathy, Immunocompromised Host	Stem Cell Exhaustion	BK polyomavirus (BKPyV) can cause hemorrhagic cystitis (HC) in allogeneic hematopoietic stem cell transplant (allo-HSCT) patients and polyomavirus-associated nephritis in renal transplant patients, while JC polyomavirus (JCPyV) can generate progressive multifocal leukoencephalopathy in immunocompromised individuals.	26809742
Primary central nervous system lymphoma	Stem Cell Exhaustion	Primary central nervous system lymphoma in daily practice and the role of autologous stem cell transplantation in relapsed disease: A retrospective multicenter study.	26810141
Malignant Neoplasms	Stem Cell Exhaustion	Allogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host Disease.	26811520
Cessation of life, Malignant Neoplasms	Stem Cell Exhaustion	Progressive malignancy is the leading cause of death after allogeneic hematopoietic stem-cell transplantation (alloHSCT).	26811520
Central neuroblastoma	Stem Cell Exhaustion	Importantly, we demonstrate that catechol-derived oxidants can be quantified in human neuroblastoma cells and midbrain dopamine neurons derived from induced pluripotent stem cells, providing a novel model to study the downstream actions of o-quinones.	26813311
Specialty Type - cancer	Stem Cell Exhaustion	We showed that the EMT program induced by PRMT1 endowed the human mammary epithelial cells with cancer stem cell properties.	26813495
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	CD45RA, a specific marker for leukaemia stem cell sub-populations in acute myeloid leukaemia.	26814163
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Chemotherapy resistant leukaemic stem cells (LSC) are thought to be responsible for relapses after therapy in acute myeloid leukaemia (AML).	26814163
Kernicterus	Stem Cell Exhaustion	We have investigated the effectiveness of human adiposity-derived stem cells as a therapeutic paradigm for perinatal neuronal repair in a kernicterus animal model.	26818600
Neurologic Deficits, Brain Injuries	Stem Cell Exhaustion	This study provides important information for the development of therapeutic strategies using human adiposity-derived stem cells in prenatal brain damage to reduce potential sensori motor deficit.	26818600
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The precise phenotype and biology of acute myeloid leukemia stem cells remain controversial, in part because the "gold standard" immunodeficient mouse engraftment assay fails in a significant fraction of patients and identifies multiple cell-types in others.	26819054
leukemia	Stem Cell Exhaustion	The CD34(+)CD38(-) leukemia cells in 47 of the 80 patients displayed intermediate aldehyde dehydrogenase expression, while normal CD34(+)CD38(-) hematopoietic stem cells expressed high levels of aldehyde dehydrogenase.	26819054
leukemia	Stem Cell Exhaustion	The strong clinical correlations suggest that the most immature phenotype detectable in the leukemia might serve as a biomarker for "clinically-relevant" leukemia stem cells.	26819054
Vascular Hemostatic Disorders, Anemia, Infection, Blood Platelet Disorders, Blood coagulation	Stem Cell Exhaustion	This progress highlights the potential of focused basic research programs such as this EHA Roadmap.The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation.	26819058
Disease, malignant disease	Stem Cell Exhaustion	These sections span 60 smaller groups of diseases or disorders.The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients.	26819058
leukemia	Stem Cell Exhaustion	Donor leukocyte infusion (DLI) is used to treat relapsed leukemia after allogeneic hematopoietic stem cell transplant (HCT).	26820493
Specialty Type - cancer	Stem Cell Exhaustion	POU5F1 is a key regulator of self-renewal and differentiation in embryonic stem cells and may be associated with initiation, promotion, and progression in cancer.	26824036
Cell Death, Myocardial Ischemia	Stem Cell Exhaustion	In conventional stem cell transplantation therapies for ischemic limb diseases, stem cells are generally transplanted into the ischemic region (IR), and most of the transplanted cells undergo hypoxia-mediated cell death.	26824782
Ischemia	Stem Cell Exhaustion	In this study, we investigated whether the therapeutic efficacy can be improved and the cell dosage can be reduced in the therapy for limb ischemia simply by modifying the stem cell injection site to a site where cell engraftment is improved and blood vessel sprouting is efficiently stimulated.	26824782
Myocardial Ischemia	Stem Cell Exhaustion	Therefore, modification of the stem cell transplantation site would improve the current stem cell therapies for ischemic limb diseases in terms of cell dosage reduction and therapeutic efficacy enhancement.	26824782
Cell Death	Stem Cell Exhaustion	Due to massive cell death, the therapeutic efficacy is reduced and a high dose of stem cells is necessitated for the therapies.	26824782
Cessation of life	Stem Cell Exhaustion	Human mesenchymal stem cells (hMSCs) cultured under hypoxic condition, which simulates cells transplanted to IR, underwent extensive cell death in vitro.	26824782
Hepatic Veno-Occlusive Disease, Venoocclusive disease	Stem Cell Exhaustion	Hepatic veno-occlusive disease (VOD), also called sinusoidal obstruction syndrome (SOS), is a potentially life-threatening complication of hematopoietic stem cell transplantation (HSCT).	26825712
Neoplasms	Stem Cell Exhaustion	Cytokeratin-positive interstitial reticulum cell (CIRC) tumor is a very rare accessory cell neoplasm of lymphoid organs derived from fibroblastic reticulum cells, which originate from mesenchymal stem cells.	26826404
Impaired T cell function, Thrombosis	Stem Cell Exhaustion	Downregulation of let-7e-5p contributes to endothelial progenitor cell dysfunction in deep vein thrombosis via targeting FASLG.	26826505
Deep Vein Thrombosis, Thrombosis	Stem Cell Exhaustion	This study aimed to evaluate the role of let-7e-5p in endothelial progenitor cells (EPCs) function and explore its therapeutic potential for deep vein thrombosis (DVT).	26826505
BCR gene	Stem Cell Exhaustion	Allogeneic stem cell transplantations are indicated in high-risk subgroups of infant ALL (age below 6 months, high hyperleucocytosis >300.10(9)/L, MLL-rearrangement, initial poor prednisone response).	26826739
Multiple Myeloma	Stem Cell Exhaustion	This phase Ib clinical trial evaluated whether pretargeting of CD20(+) clonogenic myeloma precursor cells (CMPCs) with anti-CD3 x anti-CD20 bispecific antibody-armed T cells (BATs) before autologous stem cell transplantation (SCT) in patients with standard-risk and high-risk multiple myeloma would induce antimyeloma immunity that could be detected and boosted after SCT.	26827660
leukemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	A Study of Human Leukocyte Antigen Mismatched Cellular Therapy (Stem Cell Microtransplantation) in High-Risk Myelodysplastic Syndrome or Transformed Acute Myelogenous Leukemia.	26838271
Toxic effect, PAFAH1B1 wt Allele	Stem Cell Exhaustion	We designed a combination of human leukocyte antigen (HLA)-mismatched hematopoietic stem cell microtransplantation (MST) with chemotherapy for patients with MDS and tAML and evaluated its effects and toxicity.	26838271
Graft-vs-Host Disease	Stem Cell Exhaustion	It aims to support hematopoietic recovery and perform graft-versus-leukemia (GVL) effects but differs from traditional allogeneic stem cell transplantation because the rate of donor cell chimerism is low and there is and no graft-versus-host disease (GVHD) risk.	26838271
Specialty Type - cancer, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Cancer stem cell theory indicates cancer stem cells are the key to promote tumor invasion and metastasis.	26840020
Pancreatic carcinoma, Secondary Neoplasm	Stem Cell Exhaustion	Polycomb complex protein BMI-1 promotes invasion and metastasis of pancreatic cancer stem cells by activating PI3K/AKT signaling, an ex vivo, in vitro, and in vivo study.	26840020
Pancreatic carcinoma	Stem Cell Exhaustion	Then, we found that BMI-1 expression was up-regulated in pancreatic cancer stem cells.	26840020
Pancreatic carcinoma, Secondary Neoplasm	Stem Cell Exhaustion	Knockdown of BMI-1 expression attenuated invasion ability of pancreatic cancer stem cells in Transwell system and liver metastasis capacity in nude mice which were injected CSCs through the caudal vein.	26840020
Pancreatic carcinoma, Secondary Neoplasm	Stem Cell Exhaustion	We are the first to reveal that BMI-1 could promote invasion and metastasis ability of pancreatic cancer stem cells.	26840020
Hematologic Neoplasms	Stem Cell Exhaustion	Help-seeking behaviour of patients with haematological malignancies treated with autologous stem cell transplantation.	26840911
Hematologic Neoplasms	Stem Cell Exhaustion	Patients with haematological malignancies undergoing autologous stem cell transplantation face a life-threatening illness and stressful treatment.	26840911
Gastrointestinal mucositis	Stem Cell Exhaustion	[Mouthrinse in oral mucositis in the context of allogeneic stem cell transplantation: a qualitative study].	26845653
Gastrointestinal mucositis	Stem Cell Exhaustion	Oral mucositis is a common side effect of allogeneic stem cell transplantation and can lead to increased morbidity, mortality and higher costs.	26845653
Malignant neoplasm of lung, Non-Small Cell Lung Carcinoma, Neoplasms	Stem Cell Exhaustion	A novel paradigm in tumor biology suggests that non-small cell lung cancer (NSCLC) growth is driven by lung cancer stem cell-like cells (LCSCs), but molecular mechanisms regulating tumorigenic and self-renewal potential of LCSCs are still unclear.	26846105
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	Our findings testified that CD166(+) cells which were derived from fresh primary NSCLC samples displayed stem cell-like features.	26846105
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	The effects and mechanisms of SLC34A2 on tumorigenicity in human non-small cell lung cancer stem cells.	26846105
Bronchiolitis	Stem Cell Exhaustion	Risk Factor and Clinical Outcome of Bronchiolitis Obliterans Syndrome after Allogeneic Hematopoietic Stem Cell Transplantation.	26847288
Bronchiolitis Obliterans, Bosnian language	Stem Cell Exhaustion	The development of bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic stem cell transplantation (HSCT) deteriorates patients' quality of life.	26847288
Sexual Dysfunction, Infertility	Stem Cell Exhaustion	Four hundred and twenty-one adult allogeneic haematopoietic stem cell transplant (HSCT) survivors participated in a cross-sectional study to assess sexual dysfunction and infertility post-transplant.	26847746
Thrombus, Anemia, Hemolytic, Pancytopenia, Paroxysmal nocturnal hemoglobinuria, Acquired disorder	Stem Cell Exhaustion	PNH is a rare acquired disorder of haematopoietic stem cells, characterised by haemolytic anaemia, pancytopenia and thrombotic events classically involving the venous system.	26847804
Malignant neoplasm of ovary, Specialty Type - cancer	Stem Cell Exhaustion	Ovarian cancer treatment remains a challenge and targeting cancer stem cells presents a promising strategy.	26848771
Calcinosis	Stem Cell Exhaustion	Pharmacological Regulation of In Situ Tissue Stem Cells Differentiation for Soft Tissue Calcification Treatment.	26851078
Hypoxia	Stem Cell Exhaustion	Proinflammatory microenvironment, rather than hypoxia, is correlated with HIF-2alpha activation and promoted osteochondrogenic differentiation of tendon stem/progenitor cells (TSPCs).	26851078
Calcinosis	Stem Cell Exhaustion	Taken together, these findings reveal the significant role of the tissue stem/progenitor cells fate decision and suggest that pharmacological regulation of HIF-2alpha function is a promising approach for soft tissue calcification treatment.	26851078
Asthma, Atopy	Stem Cell Exhaustion	Stem Cell Factor and Interleukin-31 Expression: Association with IgE among Egyptian Patients with Atopic and Nonatopic Bronchial Asthma.	26853551
Asthma, Stem Cell Factor	Stem Cell Exhaustion	Recently, it has been reported that the stem cell factor (SCF) and interleukin-31 (IL-31) may play a major role in bronchial asthma.	26853551
Asthma, Atopy	Stem Cell Exhaustion	The aim of the current study was to study the association of the stem cell factor and interleukin-31 expression with serum immunoglobulin E among Egyptian patients with atopic and nonatopic bronchial asthma.	26853551
Cessation of life	Stem Cell Exhaustion	Overall, 38 (78%) of 49 patients are in continuous complete remission, including 13 of 18 after haemopoietic stem cell transplantation, with three deaths in induction, five deaths after haemopoietic stem cell transplantation, and three relapses.	26853647
Acute lymphocytic leukemia	Stem Cell Exhaustion	The role of innovative therapies and haemopoietic stem cell therapy in early T-cell precursor acute lymphoblastic leukaemia needs to be assessed.	26853647
Viremia	Stem Cell Exhaustion	Viraemia, immunogenicity, and survival outcomes of cytomegalovirus chimeric epitope vaccine supplemented with PF03512676 (CMVPepVax) in allogeneic haemopoietic stem-cell transplantation: randomised phase 1b trial.	26853648
Systolic dysfunction	Stem Cell Exhaustion	Pre-transplant diastolic but not systolic dysfunction has a negative prognostic impact after allogeneic stem cell transplantation.	26855153
Specialty Type - cancer	Stem Cell Exhaustion	Interdisciplinary care programme to improve self-management for cancer patients undergoing stem cell transplantation: a prospective non-randomised intervention study.	26857103
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cell-tumor microenvironment ecosystem is proposed to drive tumor heterogeneity.	26857534
Childhood Breast Carcinoma	Stem Cell Exhaustion	Breast cancer stem cells phenotype and plasma cell-predominant breast cancer independently indicate poor survival.	26857534
Childhood Breast Carcinoma	Stem Cell Exhaustion	This study sought to detect the association between breast cancer stem cells and TILs.	26857534
Childhood Breast Carcinoma	Stem Cell Exhaustion	Matched cancerous and paracancerous tissues were assembled in a tissue microarray and immunohistochemistry was employed to test expression of breast cancer stem cells (BCSCs) markers.	26857534
Lymphoma, Non-Hodgkin, Familial, Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	This phase II study evaluated YM155, a novel small-molecule survivin suppressant, in combination with rituximab in patients with relapsed aggressive B-cell non-Hodgkin lymphoma (NHL) who failed or were not candidates for autologous stem cell transplant (ASCT).	26857688
Diabetes Mellitus	Stem Cell Exhaustion	Long-Term Insulin Independence in Type 1 Diabetes Mellitus Using a Simplified Autologous Stem Cell Transplant.	26859103
Diabetes Mellitus, Insulin-Dependent	Stem Cell Exhaustion	Efforts to find a cure for type 1 diabetes have focused on the removal of the autoimmune pathophysiologic substrate, with the use of immunosuppressive regimens including autologous hematopoietic stem cell transplantation (AHSCT).	26859103
Multiple Myeloma	Stem Cell Exhaustion	[Monomorphic post-transplant T-lymphoproliferative disorder after autologous stem cell transplantation for multiple myeloma].	26861102
Post-transplant lymphoproliferative disorder, Lymphoproliferative Disorders	Stem Cell Exhaustion	We report a rare case of T cell type monomorphic post-transplant lymphoproliferative disorders (PTLD) after autologous stem cell transplantation.	26861102
Multiple Myeloma	Stem Cell Exhaustion	A 53-year-old man with multiple myeloma received autologous stem cell transplantation and achieved a very good partial response.	26861102
Acute Promyelocytic Leukemia	Stem Cell Exhaustion	[Multiple organ failure presumably due to alkylating agents used as preconditioning drugs for autologous peripheral blood stem cell transplantation in an acute promyelocytic leukemia].	26861103
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) are mobilized from the bone marrow and increase in the early phase after ST-elevation myocardial infarction (STEMI).	26864952
Infected	Stem Cell Exhaustion	The majority of infected patients (n = 75/111) underwent stem cell transplantation (42 autologous, 48 allogeneic, 15 autologous and allogeneic).	26866481
Specialty Type - cancer, Squamous cell carcinoma of oropharynx	Stem Cell Exhaustion	Impact of Expression of CD44, a Cancer Stem Cell Marker, on the Treatment Outcomes of Intensity Modulated Radiation Therapy in Patients With Oropharyngeal Squamous Cell Carcinoma.	26867875
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Long noncoding RNA (lncRNA) HOX antisense intergenic RNA (HOTAIR) has recently emerged as a key molecule in many cancers, triggering epithelial-mesenchymal transition (EMT)-mediated cancer stem cell (CSC) formation, but little is known about its significance in EC.	26868332
Endometrial Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	HOTAIR in relation to epithelial-mesenchymal transition and cancer stem cells in molecular subtypes of endometrial cancer.	26868332
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Oral acute graft-versus-host disease (aGVHD) is a significant sequelae of allogeneic hematopoietic stem cell transplantation (HSCT).	26868474
Neoplasms	Stem Cell Exhaustion	We analyzed patients with BC before and after NACT for disseminated tumor cells (DTCs) in the bone marrow(BM); comprehensively characterized circulating tumor cells (CTCs), including stem cell-like CTCs (slCTCs), in blood to prove the effectiveness of treatment on these cells; and correlated these findings with response to therapy, progression-free survival (PFS), and overall survival (OS).	26868521
Neoplasms	Stem Cell Exhaustion	Although CTCs were eradicated more effectively than DTCs, CTCs detected after treatment seemed to be associated with tumor cells showing tumor stem cell characteristics as well as with resistant tumor cell populations that might indicate a worse outcome in the future.	26868521
Acute leukemia	Stem Cell Exhaustion	Posaconazole oral suspension primary prophylaxis in acute leukemia and allogeneic stem cell transplant patients: can it be used without measurement of plasma concentration?	26868905
Acute leukemia	Stem Cell Exhaustion	Overall, 103 acute leukemia (AL) patients submitted to intensive chemotherapy (115 courses) and 46 allogeneic stem cell transplant (allo-SCT) recipients (47 courses) receiving PCZ-susp prophylaxis were considered.	26868905
Dental Plaque	Stem Cell Exhaustion	Involvement of circulating endothelial progenitor cells in carotid plaque growth and vulnerability.	26871204
Dental Plaque	Stem Cell Exhaustion	OBJECTIVE The roles of endothelial progenitor cells (EPCs) in the development of carotid plaque are still obscure.	26871204
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GVHD) is one of the major complications after hematopoietic stem cell transplantation and is responsible for post-therapeutic morbidity, mortality, and poor quality of life of recipients.	26871550
Agammaglobulinemia	Stem Cell Exhaustion	Allogeneic stem cell transplantation for X-linked agammaglobulinemia using reduced intensity conditioning as a model of the reconstitution of humoral immunity.	26873735
X-linked agammaglobulinemia, Agammaglobulinemia	Stem Cell Exhaustion	We herein report the first case of X-linked agammaglobulinemia (XLA) that underwent allogeneic stem cell transplantation using reduced intensity conditioning (RIC).	26873735
X-linked agammaglobulinemia, Episode of	Stem Cell Exhaustion	The patient was a 28-year-old Japanese male with XLA who previously had life-threatening infectious episodes and was referred for the possible indication of allogeneic stem cell transplantation.	26873735
immunoglobulin A	Stem Cell Exhaustion	Regarding immune reconstitution, CD19(+) cells, IgA, and IgM, which were undetectable before allogeneic stem cell transplantation (allo-SCT), started to increase in number 10 days after allo-SCT and continued to increase for more than 1 year.	26873735
Cutaneous	Stem Cell Exhaustion	Despite aggressive management, including chemotherapy and stem-cell transplantation, most patients died of progressive disease within a few months after the development of cutaneous lesions.	26874821
Anemia, Hematopoietic stem cells, Dysplasia	Stem Cell Exhaustion	This defect resulted in age-dependent progressive anemia, megakaryocyte dysplasia and loss of hematopoietic stem cell (HSC) quiescence.	26878232
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	mTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance.	26878385
Glioblastoma Multiforme Pathway, Adult Glioblastoma	Stem Cell Exhaustion	SOX2 and SOX9 are commonly overexpressed in glioblastoma, and regulate the activity of glioma stem cells (GSCs).	26878385
Allogeneic Hematopoietic Stem Cell Transplantation, Toxic effect, Sexual function	Stem Cell Exhaustion	Treatment with allogeneic hematopoietic stem cell transplantation (HSCT) is associated with short and long-term toxicities that can result in alterations in sexual functioning.	26878660
Mycoses	Stem Cell Exhaustion	This case shows that molecular genetic-based methods may be effective for detecting undetermined invasive fungal infections in stem cell transplantation settings.	26879198
Multiple Myeloma	Stem Cell Exhaustion	High dose melphalan (HDM) and autologous stem cell transplantation (ASCT) retains a central role in the treatment of myeloma.	26879446
Acute lymphocytic leukemia	Stem Cell Exhaustion	Sustaining integrating imatinib and interferon-a into maintenance therapy improves survival of patients with Philadelphia positive acute lymphoblastic leukemia ineligible for allogeneic stem cell transplantation.	26879808
Lymphoma	Stem Cell Exhaustion	This study was conducted to evaluate its efficacy and optimal dose in Indian patients with relapsed/refractory lymphoma who were unable or unwilling to undergo autologous hematopoietic stem cell transplant.	26881531
Antilymphocyte Serum	Stem Cell Exhaustion	Autologous Peripheral Blood Stem Cell Transplantation Improves Neural Electrophysiological Function in Patients with ALS.	26882810
Antilymphocyte Serum	Stem Cell Exhaustion	The present research examined whether autologous peripheral blood stem cell transplantation (APBSCT) could improve neural electrophysiological function in 21 patients with ALS.	26882810
Antilymphocyte Serum	Stem Cell Exhaustion	21 patients with ALS were injected with autologous peripheral blood stem cells, and the measurements were assessed prior to APBSCT at 1, 3, and 6 months after transplantation.	26882810
Acute leukemia	Stem Cell Exhaustion	Impact of cytomegalovirus reactivation on relapse and survival in patients with acute leukemia who received allogeneic hematopoietic stem cell transplantation in first remission.	26883100
leukemia	Stem Cell Exhaustion	Cytomegalovirus (CMV)-reactivation is associated with graft-vs-leukemia (GVL) effect by stimulating natural-killer or T-cells, which showed leukemia relapse prevention after hematopoietic stem cell transplantation (HSCT).	26883100
Prostate carcinoma, Secondary Neoplasm	Stem Cell Exhaustion	SREBP-2 promotes stem cell-like properties and metastasis by transcriptional activation of c-Myc in prostate cancer.	26883200
Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Furthermore, overexpression of SREBP-2 increased the PCa stem cell population, prostasphere-forming ability and tumor-initiating capability, whereas genetic silencing of SREBP-2 inhibited PCa cell growth, stemness, and xenograft tumor growth and metastasis.	26883200
Secondary Neoplasm, Passive Cutaneous Anaphylaxis	Stem Cell Exhaustion	Collectively, these clinical and experimental results reveal a novel role of SREBP-2 in the induction of a stem cell-like phenotype and PCa metastasis, which sheds light on translational potential by targeting SREBP-2 as a promising therapeutic approach in PCa.	26883200
Deterioration	Stem Cell Exhaustion	Hematopoietic stem cell transplantation has been found effective in slowing cerebral deterioration and improving long-term survival.	26883615
Discolored Medical Device Material, Adrenoleukodystrophy	Stem Cell Exhaustion	The purpose of this case report was to describe the multidisciplinary management of red, discolored, pulpally treated primary molars identified in a nine-year-old Russian boy with childhood cerebral X-linked adrenoleukodystrophy preparing for myeloablative conditioning chemotherapy followed by hematopoietic stem cell transplantation.	26883615
Gastrointestinal Stromal Tumors	Stem Cell Exhaustion	Some authors suggest common origin of gastrointestinal stromal tumors from stem cells, which may show diverse differentiation.	26884872
Adult Myelodysplastic Syndrome, Acute leukemia	Stem Cell Exhaustion	The efficacy and safety of a new reduced-toxicity conditioning with 4 days of once-daily 100 mg/m(2) intravenous busulfan associated with fludarabine and antithymocyte globulins prior to allogeneic stem cell transplantation in patients with high-risk myelodysplastic syndrome or acute leukemia.	26885686
Juvenile Myelomonocytic Leukemia, leukemia	Stem Cell Exhaustion	The stem cell character of juvenile myelomonocytic leukemia was confirmed by successful serial transplantation that resulted in leukemia cell propagation for more than one year.	26888021
Cachexia, Juvenile Myelomonocytic Leukemia	Stem Cell Exhaustion	Key characteristics of juvenile myelomonocytic leukemia were reproduced, including cachexia and clonal expansion of myelomonocytic progenitor cells that infiltrated bone marrow, spleen, liver and, notably, lung.	26888021
Progeria	Stem Cell Exhaustion	Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation.	26890144
Heart failure, Hyperbilirubinemia	Stem Cell Exhaustion	The present study focus on patient-inspired ex vivo liver tissue engineering strategy to generate hepatocyte-scaffold composite by combining bone marrow mesenchymal stem cells (BMSCs) derived from cardiac failure patients with secondary hyperbilirubinemia as primers of hepatic differentiation and hepatocyte growth factor (HGF)-enriched sera from same individuals as hepatic inducer.	26890619
Metabolic Syndrome X	Stem Cell Exhaustion	Black Raspberry Extract Increased Circulating Endothelial Progenitor Cells and Improved Arterial Stiffness in Patients with Metabolic Syndrome: A Randomized Controlled Trial.	26891216
Arterial Stiffness, Metabolic Syndrome X	Stem Cell Exhaustion	We investigated short-term effects of black raspberry on circulating endothelial progenitor cells (EPCs) and arterial stiffness in patients with metabolic syndrome.	26891216
Blindness	Stem Cell Exhaustion	Patients develop progressive total bilateral limbal stem cell deficiency, which eventually results in corneal blindness.	26891374
Hypoplasia	Stem Cell Exhaustion	In addition, siRNA treatment led to longer acquired life span of mutated stem cells compared to controls, less accelerated stem cell differentiation in vitro, reduced proliferation properties, and effective ability in correcting the epithelial hypoplasia, thus giving rise to full thickness stratified and differentiated epithelia.	26891374
ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 1	Stem Cell Exhaustion	This study demonstrates the phenotypic correction of mutant stem cells (OMESCs) in EEC syndrome by means of siRNA mediated AS silencing with restoration of function.	26891374
Refractory Cytopenia of Childhood	Stem Cell Exhaustion	It has been reported that Vhl knock-out mice did not develop RCC, but Vhl knock-out mice with single allele loss of Bap1 in nephron progenitor cells developed RCC, indicating that Bap1 inactivation may be essential in murine renal tumorigenesis.	26891804
Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	Circulating Tumor Cells and Tumor Stem Cells Detection in the Peripheral Blood Mononuclear Cells of Breast Cancer.	26892105
Neoplasms, Childhood Breast Carcinoma, Secondary Neoplasm	Stem Cell Exhaustion	Both CTCs and tumor stem cells (TSCs) could be detected in the PBMC of breast cancer patients; besides, positive expression rate of CTCs might be obviously associated with the clinical stage and metastasis.	26892105
Prostate carcinoma, Neoplasms, Passive Cutaneous Anaphylaxis	Stem Cell Exhaustion	Subpopulations of prostate cancer (PCa) cells expressing putative stem cell markers possess the ability to promote tumor growth, maintenance, and progression.	26894647
Prostatic Neoplasms	Stem Cell Exhaustion	This study aimed to evaluate the expression patterns and clinical significance of putative stem cell marker aldehyde dehydrogenase 1 A1 (ALDH1A1) in prostate tumor tissues.	26894647
Aggressive behavior, Specialty Type - cancer, Passive Cutaneous Anaphylaxis, Neoplastic Cell Transformation	Stem Cell Exhaustion	The significant association between ALDH1A1 expressions with Gleason score indicates the potential role of this protein in PCa tumorigenesis and aggressive behavior; therefore, this cancer stem cell marker can be used as a promising candidate for targeted therapy of PCa, especially those with high Gleason score.	26894647
Specialty Type - cancer	Stem Cell Exhaustion	In addition, a subpopulation of therapy resistant cells with EMT and cancer stem cell features was identified that was resistant to the standard treatment regimen but sensitive to pemetrexed pretreatment combined with cisplatin.	26895954
Specialty Type - cancer, Neoplasms, Glioblastoma	Stem Cell Exhaustion	A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo.	26896279
Specialty Type - cancer, Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	Many cancers feature cellular hierarchies that are driven by tumor-initiating cancer stem cells (CSC) and rely on complex interactions with the tumor microenvironment.	26896279
Extrapulmonary Small Cell Carcinoma, Specialty Type - cancer, Squamous cell carcinoma of esophagus	Stem Cell Exhaustion	The p75 neurotrophin receptor (p75NTR) is a cancer stem cell (CSC) marker in esophageal squamous cell carcinoma (ESCC).	26897248
physiopathological, Lymphoma	Stem Cell Exhaustion	Valvular Dysfunction in Lymphoma Survivors Treated With Autologous Stem Cell Transplantation: A National Cross-Sectional Study.	26897666
physiopathological	Stem Cell Exhaustion	This study assessed the prevalence and associated risk factors for valvular dysfunction (VD) observed in adult lymphoma survivors (LS) after autologous hematopoietic stem cell transplantation (auto-HCT), and to determine whether anthracycline-containing chemotherapy (ACCT) alone in these patients is associated with VD.	26897666
Chemotherapy-Induced Febrile Neutropenia	Stem Cell Exhaustion	The role of biosimilar granulocyte colony stimulating factor (GCSF) Zarzio for progenitor cell mobilization and the treatment of therapy-induced neutropenia in adult hematopoietic stem cell transplantation.	26897866
Chemotherapy-Induced Febrile Neutropenia	Stem Cell Exhaustion	Originator GCSF (Neupogen) has been used to mobilize progenitor stem cells and treat therapy-induced neutropenia in Canadian stem cell transplant settings for years.	26897866
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	The cancer stem cells (CSCs) represent a minority of tumor cells that are able to proliferate and self-renew and might be responsible for tumor initiation and maintenance.	26898076
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The MSI2 RNA-binding protein has been demonstrated to have a role in acute myeloid leukaemia and stem cell function, but its role in MDS is unknown.	26898884
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	MSI2 is required for maintaining activated myelodysplastic syndrome stem cells.	26898884
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Conditional deletion of Msi2 in a mouse model of MDS results in a rapid loss of MDS haematopoietic stem and progenitor cells (HSPCs) and reverses the clinical features of MDS.	26898884
Mantle cell lymphoma	Stem Cell Exhaustion	The MCL-002 (SPRINT) study was a randomised, phase 2 study of patients with mantle cell lymphoma aged 18 years or older at 67 clinics and academic centres in 12 countries who relapsed one to three times, had Eastern Cooperative Oncology Group performance status of 0-2, at least one measurable lesion to be eligible, and who were ineligible for intensive chemotherpy or stem-cell transplantation.	26899778
Mantle cell lymphoma	Stem Cell Exhaustion	Patients with relapsed or refractory mantle cell lymphoma ineligible for intensive chemotherapy or stem-cell transplantation have longer progression-free survival, with a manageable safety profile when treated with lenalidomide compared with monotherapy investigator's choice options.	26899778
Colonization	Stem Cell Exhaustion	Impact of Gut Colonization by Antibiotic-Resistant Bacteria on the Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective, Single-Center Study.	26900084
Graft-vs-Host Disease	Stem Cell Exhaustion	There is also accumulating evidence on the immunomodulatory function of gut microbiota after allogeneic stem cell transplantation (alloSCT) and its impact on graft-versus-host disease (GVHD).	26900084
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	EBV-associated post-transplant lymphoproliferative disease (PTLD) remains an important complication of allogeneic haematopoietic stem cell transplantation (allo-HSCT).	26901708
homoserine kinase activity, Herpetic whitlow, Communicable Diseases	Stem Cell Exhaustion	The expression of NOD1, NOD2, NLRP1, and NLRP3 was analyzed using real-time RT-PCR in (1) corneas with active infection, history of herpetic stromal keratitis (HSK), chronic allograft rejection, and limbal stem cell deficiency (LSCD), and (2) human corneal cells after lipopolysaccharide (LPS) stimulation.	26902715
Graft-vs-Host Disease	Stem Cell Exhaustion	We studied the impact of a set of immune cells contained within granulocyte colony-stimulating factor-mobilized peripheral blood stem cell grafts (naive and memory T-cell subsets, B cells, regulatory T cells, invariant natural killer T cells [iNKTs], NK cells, and dendritic cell subsets) in patients (n = 80) undergoing allogeneic stem cell transplantation (SCT), using the composite end point of graft-versus-host disease (GVHD)-free and progression-free survival (GPFS) as the primary end point.	26903546
Parainfluenza Virus Infections	Stem Cell Exhaustion	DAS181 for Treatment of Parainfluenza Virus Infections in Hematopoietic Stem Cell Transplant Recipients at a Single Center.	26904972
Respiratory Tract Infections	Stem Cell Exhaustion	Parainfluenza virus (PIV) causes severe respiratory infections in hematopoietic stem cell transplant (HSCT) recipients.	26904972
Multiple Myeloma	Stem Cell Exhaustion	The efficacy and safety of thalidomide as an initial treatment in myeloma patients who were unsuitable for autologous stem cell transplantation (ASCT), as induction treatment prior to ASCT, or as a maintenance treatment was unclear.	26906553
LIPC gene	Stem Cell Exhaustion	Those HL patients, who cannot be cured at least with salvage therapy (including autologous haemopoietic stem cell transplantation (auto-HSCT)), have really unfavourable prognosis.	26907830
Respiratory Syncytial Virus Infections	Stem Cell Exhaustion	Corticosteroid use as adjunct therapy for respiratory syncytial virus infection in adult allogeneic stem cell transplant recipients.	26909896
Communicable Diseases	Stem Cell Exhaustion	Respiratory syncytial virus (RSV) infection causes significant morbidity and mortality in allogeneic stem cell transplant (allo-SCT) recipients.	26909896
Aplastic Anemia	Stem Cell Exhaustion	Impact of cyclophosphamide dose of conditioning on the outcome of allogeneic hematopoietic stem cell transplantation for aplastic anemia from human leukocyte antigen-identical sibling.	26910242
Aplastic Anemia	Stem Cell Exhaustion	The standard conditioning regimen in allogeneic hematopoietic stem cell transplantation (HSCT) for aplastic anemia from a human leukocyte antigen (HLA)-identical sibling has been high-dose cyclophosphamide (CY 200 mg/kg).	26910242
Graft-vs-Host Disease	Stem Cell Exhaustion	Older recipient and donor age were associated with higher incidences of severe graft-versus-host disease (GVHD) and mortality after allogeneic hematopoietic stem cell transplantation from matched sibling donors (MSDs) and matched unrelated donors.	26910296
Acute lymphocytic leukemia, BCR gene, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We retrospectively analyzed Japanese registration data of 2,091 patients with acute myeloid leukemia, acute lymphoblastic leukemia (ALL), and myelodysplastic syndrome aged 50 years or older who underwent MSD bone marrow transplantation (BMT) (n = 319), MSD peripheral blood stem cell transplantation (PBSCT) (n = 462), or unrelated CBT (n = 1,310) between 2007 and 2012.	26910296
RBBP1L1 Protein	Stem Cell Exhaustion	The AdnaTest(r) system was used to enrich epithelial cells in peripheral blood and to detect breast cancer-associated, stem cell-specific or EMT-specific transcripts.	26910601
Specialty Type - cancer	Stem Cell Exhaustion	Moreover, transcripts specific for cancer stem cells and epithelial mesenchymal transition (EMT) were assessed.	26910601
Disease	Stem Cell Exhaustion	Human bone marrow mesenchymal stem cells (hBM-MSCs) hold promise for treating incurable diseases and repairing of damaged tissues.	26910916
Hair follicle structure, Alopecia	Stem Cell Exhaustion	We show that hair follicle stem cell (HFSC) aging causes the stepwise miniaturization of hair follicles and eventual hair loss in wild-type mice and in humans.	26912707
Aortic Valve Stenosis	Stem Cell Exhaustion	Circulating Endothelial Progenitor Cells and Clinical Outcome in Patients with Aortic Stenosis.	26913741
Specialty Type - cancer, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	A national study on conditional survival, excess mortality and second cancer after high dose therapy with autologous stem cell transplantation for non-Hodgkin lymphoma.	26914167
Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma, Cessation of life, Malignant Neoplasms	Stem Cell Exhaustion	This national population-based study aimed to investigate conditional survival and standardized mortality ratios (SMR) after high-dose therapy with autologous stem-cell transplantation (HDT-ASCT) for non-Hodgkin lymphoma (NHL), and to analyse cause of death, relapses and second malignancies.	26914167
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Donor cell leukemia (DCL) is a rare complication of hematopoietic stem cell transplantation (HSCT).	26914843
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) has become the mainstay of 1st-line treatment in younger patients with multiple myeloma (MM), but statistical confirmation of its superiority over other therapies, especially in the era of novel agents, is still lacking.	26915865
Stomach Carcinoma, Specialty Type - cancer, Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSCs) are believed to contribute to the tumor growth in gastric carcinoma (GC), a common lethal malignancy.	26918728
Exanthema, Mantle cell lymphoma, Fever	Stem Cell Exhaustion	We present the case of a 62-year-old man treated with high-dose chemotherapy and consecutive autologous stem cell transplantation for mantle cell lymphoma, who developed high fever and a rash of the trunk and both axillae 10 days after stem cell transplantation.	26918962
Specialty Type - cancer, Nasopharyngeal carcinoma	Stem Cell Exhaustion	ISG15 predicts poor prognosis and promotes cancer stem cell phenotype in nasopharyngeal carcinoma.	26919245
Specialty Type - cancer	Stem Cell Exhaustion	ISG15 overexpression promoted a cancer stem cell phenotype in NPC cells, including increased colony and tumorsphere formation abilities, pluripotency-associated genes expression, and in vivo tumorigenicity.	26919245
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, Allogeneic Hematopoietic Stem Cell Transplantation	Stem Cell Exhaustion	Complete neurologic and cognitive recovery after plasmapheresis in a patient with chronic inflammatory demyelinating polyneuropathy after allogeneic hematopoietic stem cell transplantation.	26919852
neurological complication	Stem Cell Exhaustion	Neurologic complications after allogeneic hematopoietic stem cell transplantation (HSCT) are rare but poorly understood.	26919852
Ischemia	Stem Cell Exhaustion	Expansion and angiogenic potential of mesenchymal stem cells from patients with critical limb ischemia.	26921003
CLU protein, human	Stem Cell Exhaustion	Traditional revascularization options are not possible for up to 50% of CLI patients, in which case, the use of cellular therapies, such as bone marrow-derived mesenchymal stem cells (MSCs), hold great promise as an alternative revascularization therapy.	26921003
Pancytopenia	Stem Cell Exhaustion	Pure Red Cell Aplasia in Major ABO-Mismatched Allogeneic Hematopoietic Stem Cell Transplantation Is Associated with Severe Pancytopenia.	26921820
Pure Red-Cell Aplasia	Stem Cell Exhaustion	In major ABO-mismatched allogeneic hematopoietic stem cell transplantation (HSCT) persistence of antidonor isohemagglutinins leads to pure red cell aplasia (PRCA).	26921820
Secondary Graft Failure After Hematopoietic Cell Transplantation	Stem Cell Exhaustion	Two patients (15%) received a second transplant because of persistent pancytopenia/secondary graft failure, 1 (8%) died from secondary graft failure despite a stem cell boost, 1 (8%) did not recover his platelet counts despite RBC/ANC recovery, and 3 patients (23%) died from disease relapse.	26921820
Venous Thromboembolism	Stem Cell Exhaustion	Management patterns and outcomes in symptomatic venous thromboembolism following allogeneic hematopoietic stem cell transplantation.	26922092
Venous Thromboembolism, vinyltriethoxysilane	Stem Cell Exhaustion	Experience is limited with regard to antithrombotic therapy in patients with venous thromboembolism (VTE) following allogeneic hematopoietic stem cell transplantation (HSCT).	26922092
Crohn Disease	Stem Cell Exhaustion	Human Embryonic Stem Cell Therapy in Crohn's Disease: A Case Report.	26923312
Crohn Disease	Stem Cell Exhaustion	Our study aimed to evaluate the efficacy of human embryonic stem cell therapy in a patient with Crohn's disease.	26923312
Food intolerance (disorder), Diarrhea, Abdominal Pain	Stem Cell Exhaustion	A 21-year-old male with chief complaints of intolerance to specific foods, abdominal pain, and diarrhea underwent human embryonic stem cell therapy for two months.	26923312
Crohn Disease	Stem Cell Exhaustion	Human embryonic stem cell therapy might serve as a new optimistic treatment approach for Crohn's disease.	26923312
Hodgkin Disease	Stem Cell Exhaustion	Engraftment and outcomes following autologous stem cell transplantation in Hodgkin lymphoma patients mobilized with plerixafor.	26928577
Hodgkin Disease, Childhood Non-Hodgkin Lymphoma, Multiple Myeloma, LIPC gene	Stem Cell Exhaustion	Plerixafor has been used to improve peripheral blood stem cell (PBSC) mobilization in multiple myeloma, non-Hodgkin lymphoma, and very recently in Hodgkin lymphoma (HL) patients.	26928577
Autoimmune Diseases, Specialty Type - cancer, Primary immune deficiency disorder	Stem Cell Exhaustion	In addition, we computed the prevalence of certain conditions associated with immune dysregulation (stem cell or bone marrow transplantation, solid organ transplantation, HIV infection, primary immunodeficiency, any cancer, and autoimmune diseases).	26932311
Hyperparathyroidism	Stem Cell Exhaustion	Previous studies have demonstrated that recipient mice of this stem cell-based FGF2 therapy developed secondary hyperparathyroidism and increased bone resorption.	26934099
Graft-vs-Host Disease	Stem Cell Exhaustion	The lung function score and its components as predictors of overall survival and chronic graft-vs-host disease after allogeneic stem cell transplantation.	26935611
Li-Fraumeni Syndrome	Stem Cell Exhaustion	We evaluated 241 patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT) at the University of Regensburg Transplant Center between June 1998 and July 2005 in relation to their LFS, FEV1 and cDLCO, before and after HSCT.	26935611
Malignant neoplasm of ovary	Stem Cell Exhaustion	p53 determines prognostic significance of the carbohydrate stem cell marker TF1 (CD176) in ovarian cancer.	26935926
Specialty Type - cancer	Stem Cell Exhaustion	The oncofoetal Thomsen-Friedenreich (TF1, CD176) epitope is a carbohydrate cancer stem cell (CSC) antigen, and TF1-mediated cancer progression can be widely reversed by anti-TF1 antibodies.	26935926
Amyotrophic Lateral Sclerosis	Stem Cell Exhaustion	Intraspinal delivery of bone marrow stromal cell-derived neural stem cells in patients with amyotrophic lateral sclerosis: A safety and feasibility study.	26944143
Antilymphocyte Serum	Stem Cell Exhaustion	Stem cells have been used in several studies with different methodologies to treat patients with ALS.	26944143
Streptococcal Infections	Stem Cell Exhaustion	Viridans Group Streptococcal Infections in Children After Chemotherapy or Stem Cell Transplantation: A 10-year Review From a Tertiary Pediatric Hospital.	26945409
Malignant Neoplasms	Stem Cell Exhaustion	The aim of this study was to describe the characteristics, outcome, and resistance patterns of children with VGS bacteremia (VGSB) undergoing treatment of malignancy or hematopoietic stem cell transplant.	26945409
Specialty Type - cancer, Carcinoma, Transitional Cell	Stem Cell Exhaustion	Expression of Cancer Stem Cell Markers OCT4 and CD133 in Transitional Cell Carcinomas.	26945449
Failure, Neoplasms, Secondary Neoplasm, Malignant neoplasm of urinary bladder	Stem Cell Exhaustion	Treatment failure, recurrence, and metastasis in bladder cancer are attributed to a subset of tumor cells expressing cancer stem cell (CSC) markers.	26945449
Malignant Neoplasms	Stem Cell Exhaustion	Further research is needed to determine whether these malignancies originate from two different cell clones or arise from the same pluripotent hematopoietic stem cell.	26946772
Hepatitis C Virus Positive, Multiple Myeloma	Stem Cell Exhaustion	Outcomes in hepatitis C virus seropositive lymphoma and myeloma patients after autologous stem cell transplantation.	26950376
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Kinetics of versican-expressing macrophages in bone marrow after cord blood stem cell transplantation for treatment of acute myelogenous leukaemia.	26951084
Gain, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	To determine versican-producing cells in normocellular bone marrow and to evaluate chronological alteration in the number of versican-producing macrophages in bone marrow of patients with acute myelogenous leukaemia (AML) after cord blood stem cell transplantation (CBSCT) to gain insight in the significance of versican in recovery of haematopoiesis.	26951084
Hematologic Neoplasms	Stem Cell Exhaustion	The Immediacy of Illness and Existential Crisis: Patients' lived experience of under-going allogeneic stem cell transplantation for haematological malignancy.	26952683
Hematologic Neoplasms	Stem Cell Exhaustion	This paper reports a study exploring the lived experience of fifteen men and women treated with allogeneic stem cell transplant (SCT) for haematological malignancy.	26952683
Neoplasms	Stem Cell Exhaustion	Thereby we measured levels of angiogenic growth factors, tumor perfusion, circulating endothelial cells (CEC), circulating endothelial progenitor cells (CEP) and tumor endothelial markers (TEM) in patients during the course of therapy with antiangiogenic agents, and correlated them with the time to antiangiogenic progression (aTTP).	26956051
Relapsing course, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) in those unfit or ineligible for autologous stem cell transplantation is associated with a poor outcome and new treatment approaches are needed.	26956150
RAPH1 gene	Stem Cell Exhaustion	Most cases of EBV-related LPD after hematopoietic stem cell transplantation consist of EBV-positive B-cell LPD, and, to our knowledge, de novo EBV-positive T-cell LPD subsequent to transplantation has not been previously reported.	26960588
PAFAH1B1 wt Allele	Stem Cell Exhaustion	HMAs are currently the first therapeutic choice for MDS patients who are not candidates for allogeneic hematopoietic stem cell transplantation (allo-HSCT).	26960675
Aspergillus Galactomannan Antigen Test, Aspergillosis	Stem Cell Exhaustion	Changes of serum aspergillus galactomannan during hematopoietic stem cell transplantation in children with prior invasive aspergillosis.	26960808
Multiple Myeloma	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation (auto-HCT) is considered a standard therapy for transplant-eligible patients with multiple myeloma, while allogeneic HCT (allo-HCT) is controversial.	26961137
Li-Fraumeni Syndrome	Stem Cell Exhaustion	LFS was superior with MSD (P < .001), BM as graft source (P = .001), and performance scores > 90 (P = .03) compared with unrelated or mismatched peripheral blood stem cells donors and recipients with lower performance scores.	26964698
Philadelphia chromosome positive chronic myelogenous leukemia, BCR gene, Myeloid Leukemia, Chronic, Acute lymphocytic leukemia	Stem Cell Exhaustion	Concomitant use after hematopoietic stem cell transplantation (HSCT) for chronic myeloid leukemia (CML) or Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (ALL) may therefore result in a pharmacokinetic interaction.	26965514
Multiple Myeloma	Stem Cell Exhaustion	Granulocyte-like myeloid derived suppressor cells (G-MDSC) are increased in multiple myeloma and are driven by dysfunctional mesenchymal stem cells (MSC).	26967390
Juvenile Xanthogranuloma, Histiocytosis, Langerhans-Cell	Stem Cell Exhaustion	Langerhans cell histiocytosis (LCH) and juvenile xanthogranuloma (JXG) are thought to originate from a common stem cell precursor, with divergent differentiation under different microenvironmental conditions.	26968131
Neutropenia, Hematologic Neoplasms	Stem Cell Exhaustion	We performed a monocentric retrospective study including all patients with hematological malignancy in a ten-year period, to identify factors related to the outcome for the whole cohort and for patients with allogeneic hematopoietic stem cell transplantation (HSCT), neutropenia, or those requiring invasive mechanical ventilation (IMV).	26968953
Acute leukemia	Stem Cell Exhaustion	However, the risk of such complications in childhood acute leukemia survivors who received either central nervous system irradiation or hematopoietic stem cell transplantation is less described.	26969082
Experimental Organism Malignant Hepatocholangiocellular Carcinoma	Stem Cell Exhaustion	The expression of arginase-1, keratin (K) 8 and K18 in combined hepatocellular-cholangiocarcinoma, subtypes with stem-cell features, intermediate-cell type.	26969740
Neoplasms, Experimental Organism Malignant Hepatocholangiocellular Carcinoma	Stem Cell Exhaustion	The WHO classification describes that combined hepatocellular-cholangiocarcinoma, subtypes with stem-cell features, intermediate-cell subtype (CHC-INT) is composed of tumour cells with features intermediate between hepatocytes and cholangiocytes.	26969740
Nephroblastoma, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Wilms Tumor 1 Expression and Pre-emptive Immunotherapy in Patients with Acute Myeloid Leukemia Undergoing an Allogeneic Hemopoietic Stem Cell Transplantation.	26970379
Nephroblastoma, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Minimal residual disease (MRD) was monitored by Wilms tumor 1 (WT1) expression in 207 patients with acute myeloid leukemia (AML) after an allogeneic hemopoietic stem cell transplantation (HSCT) as a trigger to initiate pre-emptive immunotherapy (IT) with cyclosporin discontinuation and/or donor lymphocyte infusion.	26970379
Primary Myelofibrosis	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation remains the sole curative option for myelofibrosis.	26970380
Graft-vs-Host Disease	Stem Cell Exhaustion	Risk of graft-versus-host disease with rituximab-containing conditioning regimens in allogeneic hematopoietic stem cell transplant.	26970572
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease represents a major cause of morbidity and mortality in allogeneic hematopoietic stem cell transplant patients.	26970572
Graft-vs-Host Disease	Stem Cell Exhaustion	The purpose of this retrospective cohort study was to evaluate the efficacy of rituximab-containing conditioning regimens in decreasing graft-versus-host disease in allogeneic hematopoietic stem cell transplant patients who received standardized tacrolimus-based graft-versus-host disease prophylaxis regimens.	26970572
Cessation of life, Acute GVH disease	Stem Cell Exhaustion	When restricting the analysis to recipients of peripheral blood hematopoietic stem cell transplants, the RTX group had a higher incidence of grade II-IV acute graft-versus-host disease, relapse, or death prior to day 100 (55% vs. 36%, p = 0.037).	26970572
Acute GVH disease	Stem Cell Exhaustion	Inhibition of antigen presentation by B cells with rituximab-based conditioning regimens does not appear to reduce the incidence of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplant recipients.	26970572
Multiple Myeloma	Stem Cell Exhaustion	Health-related physical fitness in patients with multiple myeloma or lymphoma recently treated with autologous stem cell transplantation.	26971299
Decompensated cirrhosis of liver	Stem Cell Exhaustion	Phase 1-2 pilot clinical trial in patients with decompensated liver cirrhosis treated with bone marrow-derived endothelial progenitor cells.	26972567
Decompensated cirrhosis of liver	Stem Cell Exhaustion	The aim of this nonrandomized, open label, phase 1 clinical trial was to evaluate the safety and the feasibility of the treatment with autologous bone marrow-derived endothelial progenitor cells (EPC) in decompensated liver cirrhosis.	26972567
Hematologic Neoplasms	Stem Cell Exhaustion	A novel reduced intensity conditioning regimen for patients with high-risk hematological malignancies undergoing allogeneic stem cell transplantation.	26974271
Thyroid dysfunction	Stem Cell Exhaustion	Poor growth, thyroid dysfunction and vitamin D deficiency remain prevalent despite reduced intensity chemotherapy for hematopoietic stem cell transplantation in children and young adults.	26974276
Congenital Abnormality, HIV Infections	Stem Cell Exhaustion	Hematopoietic stem cells (HSCs) and multipotent hematopoietic progenitor cells (HPCs) give rise to all blood and immune cells, and in HIV infection, hematological abnormalities frequently occur in patients.	26974413
Childhood Breast Carcinoma	Stem Cell Exhaustion	Aldehyde dehydrogenase 1 (ALDH1) has been identified as a breast cancer stem cell marker, but its value as a predictor of prognosis and chemoresistance is controversial.	26975188
Primary central nervous system lymphoma, Failure, Graft failure	Stem Cell Exhaustion	Immunocompetent adults with histologically confirmed PCNSL after experiencing high-dose methotrexate-based chemotherapy failure who were not eligible for or had experienced high-dose chemotherapy with autologous stem-cell transplant failure were included.	26976424
Acute leukemia	Stem Cell Exhaustion	Impact of conditioning intensity in T-replete haplo-identical stem cell transplantation for acute leukemia: a report from the acute leukemia working party of the EBMT.	26980295
Complement Membrane Attack Complex, Acute leukemia	Stem Cell Exhaustion	Increasing numbers of patients are receiving haplo-identical stem cell transplantation (haplo-SCT) for treatment of acute leukemia with reduced intensity (RIC) or myeloablative (MAC) conditioning regimens.	26980295
Huntingtons Disease Pathway	Stem Cell Exhaustion	Genomic Instability Associated with p53 Knockdown in the Generation of Huntington's Disease Human Induced Pluripotent Stem Cells.	26982737
HD Term Type	Stem Cell Exhaustion	We generated induced pluripotent stem cells (iPSC) from primary dermal fibroblasts of 5 patients with HD and 5 control subjects.	26982737
Prostate carcinoma	Stem Cell Exhaustion	Prostate Stem Cell Antigen Expression in Radical Prostatectomy Specimens Predicts Early Biochemical Recurrence in Patients with High Risk Prostate Cancer Receiving Neoadjuvant Hormonal Therapy.	26982980
Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	When evaluating the efficacy of steroid pulse therapy according to the ferritin level and proportion of hemophagocytic macrophages among patients undergoing bone marrow or peripheral blood stem cell transplantation, both values were higher in responders than in non-responders.	26984072
Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	Thus, our results imply that the use of ferritin levels in combination with the proportion of hemophagocytic macrophages may be useful for the early detection of potential hemophagocytic syndrome after hematopoietic stem cell transplantation.	26984072
Specialty Type - cancer, Squamous cell carcinoma of esophagus	Stem Cell Exhaustion	p75 neurotrophin receptor expression is a characteristic of the mitotically quiescent cancer stem cell population present in esophageal squamous cell carcinoma.	26984177
Extrapulmonary Small Cell Carcinoma, CD44 Positive	Stem Cell Exhaustion	Real-time PCR analysis of sorted fractions of ESCC cell lines (KYSE cells) revealed that stem cell-related genes (Nanog, p63 and Bmi-1) and epithelial-mesenchymal transition (EMT)-related genes (N-cadherin and fibronectin) were expressed at significantly higher levels in the p75NTR-positive fractions than in the CD44-positive or CD90-positive fractions.	26984177
Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	Mitotically quiescent cancer stem cells (CSC) are hypothesized to exhibit a more aggressive phenotype involving greater therapeutic resistance and metastasis.	26984177
Transplant-Related Squamous Cell Carcinoma, Multiple Myeloma	Stem Cell Exhaustion	Edentulism and transplant-associated complications in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation.	26984247
Graft-vs-Host Disease, Acute GVH disease, Herpes	Stem Cell Exhaustion	Human herpes virus type 6 can reactivate in patients after allogeneic stem cell transplantation and has been associated with serious sequelae such as delayed engraftment and an increased risk of developing acute graft-versus-host disease (GVHD).	26984480
Herpesviridae	Stem Cell Exhaustion	This study investigated human herpes virus type 6 (HHV-6) reactivation within 60 days of transplantation in stem cell transplants utilizing single umbilical cord blood, double umbilical cord blood, or umbilical cord blood plus haploidentical stem cells.	26984480
Diabetes	Stem Cell Exhaustion	Pluripotent stem cell therapy for diabetes relies on the safety as well as the quality of derived insulin-producing cells.	26987352
Neutropenia, Poikiloderma	Stem Cell Exhaustion	Generation of poikiloderma with neutropenia (PN) induced pluripotent stem cells (iPSCs).	26987923
Adult T-Cell Lymphoma/Leukemia, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Stem Cell Exhaustion	There are few therapeutic options for patients with T-cell acute lymphoblastic leukemia (T-ALL) who have recurrent disease after initial matched sibling hematopoietic stem cell transplantation.	26990138
Adult T-Cell Lymphoma/Leukemia, leukemia	Stem Cell Exhaustion	While a second hematopoietic stem cell transplant (HSCT) from a haploidentical donor offers the conceptual possibility of greater graft versus leukemia effect, there is minimal literature to describe the efficacy of this approach in recurrent pediatric T-ALL.	26990138
Hyperplasia	Stem Cell Exhaustion	Cyclosporine-induced sebaceous hyperplasia in a hematopoetic stem cell transplant patient: delayed onset of a common adverse event.	26990469
Saint Helena Islands, Hyperplasia	Stem Cell Exhaustion	Cyclosporine-induced sebaceous hyperplasia (SH) is a well-documented entity, occurring in up to 30% of renal transplant patients treated with cyclosporine and has also been reported to occur following heart or hematopoetic stem cell transplantation (HCST).	26990469
Communicable Diseases	Stem Cell Exhaustion	We describe an outbreak of respiratory syncytial virus (RSV) infection on a hematology ward without allogeneic stem cell transplant patients.	26990584
Kounis Syndrome	Stem Cell Exhaustion	In the case of a 46-year-old male patient who - for the first time in his life - had two episodes of oral allergic syndrome upon kiwi consumption after having received myeloablative hematopoietic stem cell transplantation (HCT) from his kiwi-allergic sister, we aimed to clarify the origin of allergen reactive cells in the donor.	26990607
Low-grade intraurothelial neoplasia, Carcinoma, Transitional Cell	Stem Cell Exhaustion	Flat Intraurothelial Neoplasia Exhibiting Diffuse Immunoreactivity for CD44 and Cytokeratin 5 (Urothelial Stem Cell/Basal Cell Markers): A Variant of Intraurothelial Neoplasia Commonly Associated With Muscle-invasive Urothelial Carcinoma.	26990746
Multiple Myeloma	Stem Cell Exhaustion	Single versus tandem high-dose melphalan followed by autologous blood stem cell transplantation in multiple myeloma: long-term results from the phase III GMMG-HD2 trial.	26990892
Colorectal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Role of cancer stem cells in racial disparity in colorectal cancer.	26990997
Specialty Type - cancer	Stem Cell Exhaustion	Totally implanted access ports (PACs) are valuable tools for the treatment of patients with cancer because they ease the administration of chemotherapy, stem cells, and supportive care by reducing the rate of peripheral vein punctures.	26991711
Post-Treatment Lyme Disease Syndrome	Stem Cell Exhaustion	All solid organ or allogeneic stem cell transplant recipients with PTLDs and exfoliative cytology specimens from 1987 to 2011 were identified.	26992116
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The achievement of complete response (CR) significantly correlates with a better clinical outcome in multiple myeloma (MM) patients treated with autologous stem cell transplant (ASCT).	26992692
Neoplasms, Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology	Stem Cell Exhaustion	Significance of endothelial progenitor cells (EPC) for tumorigenesis of head and neck squamous cell carcinoma (HNSCC): possible marker of tumor progression and neovascularization?	26993659
Neoplasms	Stem Cell Exhaustion	The aim of our study was to investigate the neovascularization capacity by endothelial progenitor cells (EPC) in tumor patient as a possible predictor for tumor progression and tumor stage.	26993659
Graft-vs-Host Disease	Stem Cell Exhaustion	Gastrointestinal graft-versus-host-disease (GI-GVHD) is a major cause of nonrelapse mortality after hematopoietic stem cell transplantation (HSCT) necessitating endoscopic examinations and biopsies for diagnosis.	26995779
Meningitis	Stem Cell Exhaustion	A 35-day-old female with severe combined immunodeficiency developed cytomegalovirus (CMV) meningitis before undergoing hematopoietic stem cell transplantation.	26996725
Secondary malignant neoplasm of liver, Neoplasms	Stem Cell Exhaustion	The biliary/stem cell marker-positive group exhibited poor tumor differentiation, increased frequency of portal vein invasion and/or intrahepatic metastasis, and highly proliferative activity.	26997435
Secondary malignant neoplasm of liver, Neoplasms	Stem Cell Exhaustion	In contrast, the biliary/stem cell marker-negative and Wnt/b-catenin signaling-related marker-negative group exhibited better tumor differentiation, a decreased frequency of portal vein invasion and/or intrahepatic metastasis, and less proliferative activity.	26997435
palladium	Stem Cell Exhaustion	Our results suggest that the simultaneous administration of E2B with stem cell-derived DA progenitors can enhance the efficacy of cell transplantation therapy for PD.	26997644
Aspergillosis	Stem Cell Exhaustion	Pulmonary invasive aspergillosis (IA) is a major clinical problem in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT).	26998687
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Does quality of life impact the decision to pursue stem cell transplantation for elderly patients with advanced MDS?	26999469
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	The factors that influence utilization of reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (HCT) among medically fit older patients with advanced myelodysplastic syndromes (MDS) are largely unknown.	26999469
Multiple Myeloma	Stem Cell Exhaustion	The Intergroupe Francophone du Myelome conducted a randomized trial to compare bortezomib-thalidomide-dexamethasone (VTD) with bortezomib-cyclophosphamide-dexamethasone (VCD) as induction before high-dose therapy and autologous stem cell transplantation (ASCT) in patients with newly diagnosed multiple myeloma.	27002117
Schistosoma mansoni	Stem Cell Exhaustion	Here, we demonstrate that somatic stem cells in Schistosoma mansoni are biased towards generating a population of cells expressing factors associated exclusively with the schistosome host-parasite interface, a structure called the tegument.	27003592
Asherman Syndrome, Atrophic endometrium	Stem Cell Exhaustion	Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman's syndrome and endometrial atrophy: a pilot cohort study.	27005892
Asherman Syndrome, Atrophic endometrium	Stem Cell Exhaustion	Could cell therapy using autologous peripheral blood CD133+ bone marrow-derived stem cells (BMDSCs) offer a safe and efficient therapeutic approach for patients with refractory Asherman's syndrome (AS) and/or endometrial atrophy (EA) and a wish to conceive?	27005892
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Leukemic Stem Cell Quantification in Newly Diagnosed Patients With Chronic Myeloid Leukemia Predicts Response to Nilotinib Therapy.	27006491
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Leukemic stem cells (LSCs) may harbor important resistance to tyrosine kinase inhibitors in chronic myelogenous leukemia (CML).	27006491
Hodgkin Disease	Stem Cell Exhaustion	Updated Efficacy and Safety Data From the AETHERA Trial of Consolidation With Brentuximab Vedotin After Autologous Stem Cell Transplant (ASCT) in Hodgkin Lymphoma Patients at High Risk of Relapse.	27007008
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Resistance of leukemia stem cells (LSCs) to chemotherapy in patients with acute myeloid leukemia (AML) causes relapse of disease.	27008269
Specialty Type - cancer	Stem Cell Exhaustion	Hedgehog (Hh) signaling plays a critical role in the maintenance and differentiation of cancer stem cells.	27008269
leukemia	Stem Cell Exhaustion	Targeting GLI1 Suppresses Cell Growth and Enhances Chemosensitivity in CD34+ Enriched Acute Myeloid Leukemia Progenitor Cells.	27008269
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The purpose of the present study is to investigate the role of GLI1, the transcriptional activator of Hh signaling, in AML progenitor cells and to explore the anti-AML effects of GLI small-molecule inhibitor GANT61.	27008269
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The expression of GLI1 mRNA and protein were examined in AML progenitor cells and normal cells.	27008269
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The proliferation, colony formation, apoptosis and differentiation of AML progenitor cells were also analyzed in the presence of GANT61.	27008269
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The present findings suggested that Hh signaling was activated in AML progenitor cells.	27008269
Malignant neoplasm of stomach, Specialty Type - cancer	Stem Cell Exhaustion	Antitumor activity and inhibitory effects on cancer stem cell-like properties of Adeno-associated virus (AAV) -mediated Bmi-1 interference driven by Bmi-1 promoter for gastric cancer.	27009837
Neoplasms	Stem Cell Exhaustion	These results suggest that Ad-Bmi-1i not only inhibits tumor growth and stem cell-like phenotype by inducing cellular senescence directly, but also has an indirect anti-tumor activity by anti-angiogenesis effects via regulating PTEN/AKT/VEGF pathway.	27009837
Malignant Neoplasms	Stem Cell Exhaustion	Bmi-1 is aberrantly activated in various cancers and plays a vital role in maintaining the self-renewal of stem cells.	27009837
Tissue injury	Stem Cell Exhaustion	Fibrocytes are bone marrow-derived progenitor cells that co-express markers of leukocytes and fibroblasts and are released into the circulation in the context of tissue injury.	27012475
Kaposi Sarcoma	Stem Cell Exhaustion	A case report of immunosuppression-related Kaposi's sarcoma after autologous stem cell transplantation.	27012530
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation in first complete remission may not extend progression-free survival in patients with peripheral T cell lymphomas.	27012928
Acute GVH disease, Lymphoma	Stem Cell Exhaustion	Circulating miRNA panel for prediction of acute graft-versus-host disease in lymphoma patients undergoing matched unrelated hematopoietic stem cell transplantation.	27013207
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease (aGVHD) results in significant morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT).	27013207
Neoplasms, leukemia	Stem Cell Exhaustion	Aldehyde dehydrogenase 1 (ALDH1) consists of a family of intracellular enzymes, highly expressed in stem cells populations of leukemia and some solid tumors.	27015121
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Long-term follow-up of patients with acute myeloid leukemia surviving and free of disease recurrence for at least 2 years after autologous stem cell transplantation: A report from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.	27018549
Failure, leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Leukemia recurrence is a major cause of treatment failure after autologous stem cell transplantation for acute myeloid leukemia (AML).	27018549
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The results of the current analysis indicate that late recurrences remain a major concern after autologous stem cell transplantation among patients with AML, indicating the need for close monitoring of minimal residual disease and additional leukemic control measures after transplantation.	27018549
Lung Injury, Type-II Pneumocytes	Stem Cell Exhaustion	Alveolar type II (ATII) cells act as progenitor cells in the adult lung, contributing to alveolar repair during pulmonary injury.	27020420
Diabetes, Dilated Cardiomyopathy Pathway	Stem Cell Exhaustion	Efficacy of CD34+ Stem Cell Therapy in Nonischemic Dilated Cardiomyopathy Is Absent in Patients With Diabetes but Preserved in Patients With Insulin Resistance.	27025690
Dilated Cardiomyopathy Pathway	Stem Cell Exhaustion	The present study is the first clinical study directly evaluating the effects of altered glucose metabolism on the efficacy of CD34(+) stem cell therapy in patients with nonischemic dilated cardiomyopathy.	27025690
Heart failure	Stem Cell Exhaustion	The results offer critical insights into the physiology of stem cell mobilization in heart failure and possibly an explanation for the often conflicting results obtained with stem cell therapy for heart failure.	27025690
Heart failure	Stem Cell Exhaustion	This finding could serve as a useful tool when selecting heart failure patients for future clinical studies in the field of stem cell therapy.	27025690
Primary Myelofibrosis	Stem Cell Exhaustion	Thirty consecutive patients underwent hematopoietic stem cell transplantation for myelofibrosis (MF) at our institution.	27025789
Late Relapse of Acute Myeloid Leukemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Chemotherapy versus Hypomethylating Agents for the Treatment of Relapsed Acute Myeloid Leukemia and Myelodysplastic Syndrome after Allogeneic Stem Cell Transplant.	27026249
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic stem cell transplantation (allo-SCT) is a potentially curative treatment for high-risk acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).	27026249
Heart Diseases	Stem Cell Exhaustion	Four patients proceeded to an allogeneic stem cell transplant including two with pre-existing cardiac disease.	27028202
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Allogeneic stem cell transplantation (allo-SCT) has the potential to induce long-term remission in multiple myeloma (MM), but the role of allo-SCT in MM is controversial due to the high rate of treatment-related mortality (TRM).	27028304
Neoplasms	Stem Cell Exhaustion	Tumor tissue samples were obtained intra-operatively and cultured in neural stem cell conditions containing growth factors.	27028405
hepatotoxin	Stem Cell Exhaustion	SOS rates were 3% when GO was administered at doses <=6 mg/m(2) as monotherapy or with non-hepatotoxic agents; 28% when administered with 6-thioguanine, a hepatotoxic agent; 15% when administered as monotherapy at doses at a dose of 9 mg/m(2), and between 15% and 40% if a stem cell transplant (SCT) was performed within 3 months of GO administration.	27030962
Neoplasms	Stem Cell Exhaustion	Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation for Atypical Teratoid/Rhabdoid Tumor.	27034140
Atypical Teratoid Rhabdoid Tumor	Stem Cell Exhaustion	We prospectively evaluated the effectiveness of tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT) in improving the survival of patients with atypical teratoid/rhabdoid tumors while reducing the risks of late adverse effects from radiotherapy (RT).	27034140
Hepatic Veno-Occlusive Disease, Spondylo-ocular syndrome	Stem Cell Exhaustion	Hepatic sinusoidal obstruction syndrome (SOS) is a life-threatening syndrome that generally occurs as a complication after hematopoietic stem cell transplantation or, less commonly, after conventional chemotherapy.	27034141
Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	Cancer stem cells are responsible for the development, metastasis, recurrence, and drug resistance of cancer.	27034262
Multiple Myeloma	Stem Cell Exhaustion	Here, we profiled the myeloma B-cell immunome both to explore its predictive role in the context of autologous and allogeneic hematopoietic stem cell transplantation (HSCT) and to identify novel immunotherapeutic targets.	27034429
Graft-vs-Host Disease, leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	High CD3+ and CD34+ peripheral blood stem cell grafts content is associated with increased risk of graft-versus-host disease without beneficial effect on disease control after reduced-intensity conditioning allogeneic transplantation from matched unrelated donors for acute myeloid leukemia - an analysis from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.	27036034
Graft-vs-Host Disease	Stem Cell Exhaustion	Inconsistent results have been reported regarding the influence of graft composition on the incidence of graft versus host disease (GVHD), disease control and survival after reduced-intensity conditioning (RIC) allogeneic peripheral blood stem cell transplantation (allo-PBSCT).	27036034
Graft-vs-Host Disease	Stem Cell Exhaustion	Alternatively, novel graft-versus-host disease prophylaxis regimens are needed to substantially impact graft-versus-host disease-free, relapse-free survival with the use of peripheral blood stem cell.	27036159
Tumor necrosis, Trial Disease Assessments Domain, melphalan/prednisone protocol	Stem Cell Exhaustion	We here aimed to explore associations among gene polymorphisms of tumor necrosis factor alpha (TNFa), nitric oxide synthesis 3 (NOS3) and multi-drug resistance 1 (MDR1), clinical parameters, prognosis and survival in MM patients treated with VAD (vincristine-adriamycine-dexamethasone), MP (mephalane-prednisolone), autolougus stem cell transplantation (ASCT), BODEC (bortezomib-dexamethasone-cyclophosphamide) and TD (thalidomide-dexamethasone).	27039718
PAFAH1B1 wt Allele, Cytopenia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Primary myelodysplastic syndrome (MDS) is an acquired clonal disorder of myeloid progenitor cells, characterized by peripheral cytopenias in the presence of hypercellular marrow with dysplastic features.	27039802
Hematological Disease, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukemia (AML) is a clonal hematopoietic disorder resulting from genetic alterations in normal hematopoietic stem cells.	27039804
Lymphoma	Stem Cell Exhaustion	Efficacy of Pharmacokinetics-Directed Busulfan, Cyclophosphamide, and Etoposide Conditioning and Autologous Stem Cell Transplantation for Lymphoma: Comparison of a Multicenter Phase II Study and CIBMTR Outcomes.	27040394
Childhood Breast Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Triple negative breast cancer (TNBC) is a heterogeneous disease and is associated with the cancer stem cell (CSC), basal-like, and BRCA1 function deficient (BRCAness) subtypes.	27041672
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation is a standard treatment in multiple myeloma (MM).	27041692
Hodgkin Disease	Stem Cell Exhaustion	Autologous stem cell transplantation for patients aged 60 years or older with refractory or relapsed classical Hodgkin's lymphoma: a retrospective analysis from the French Society of Bone Marrow Transplantation and Cell Therapies (SFGM-TC).	27042842
Hodgkin Disease	Stem Cell Exhaustion	This report retrospectively analyzed the outcome of 91 patients aged 60 years or older with refractory/relapsed (R/R) classical Hodgkin's lymphoma (cHL) who underwent autologous stem cell transplantation (ASCT) between 1992 and 2013 and were reported to the French Society of Bone Marrow Transplantation and Cell Therapies registry.	27042842
Chronic graft-versus-host disease	Stem Cell Exhaustion	Accelerated bone mineral density loss (BMDL) occurs early after allogeneic stem cell transplantation (SCT) and is related to factors such as steroids and chronic GvHD.	27042843
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	The prognostic relevance of cytogenetics at diagnosis on the outcome of allogeneic hematopoietic stem cell transplantation (alloHCT) for adult acute lymphoblastic leukemia (ALL) remains unclear.	27044907
Lupus Erythematosus	Stem Cell Exhaustion	Rapamycin reverses the senescent phenotype and improves immunoregulation of mesenchymal stem cells from MRL/lpr mice and systemic lupus erythematosus patients through inhibition of the mTOR signaling pathway.	27048648
Encephalitis, St. Louis, Adolescent Behavior	Stem Cell Exhaustion	We have shown that bone marrow (BM)-derived mesenchymal stem cells (BM-MSCs) from SLE patients exhibit senescent behavior and are involved in the pathogenesis of SLE.	27048648
Multiple Myeloma	Stem Cell Exhaustion	The clinical impact of thalidomide maintenance after autologous stem cell transplantation in patients with newly diagnosed multiple myeloma in real clinical practice of Korea.	27052989
Malignant neoplasm of stomach, Specialty Type - cancer	Stem Cell Exhaustion	Dose-escalation study for the targeting of CD44v+ cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205).	27055559
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells (CSCs) have enhanced mechanisms of protection from oxidative stress.	27055559
Haiti	Stem Cell Exhaustion	The patient group consisted of 80 renal transplant (RT) recipients, 35 stem cell transplant (SCT) recipients, 13 newborns, seven heart transplant (HT) recipients and one pregnant woman.	27058329
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We compared postremission treatment with chemotherapy and hematopoietic stem cell transplantation (HSCT) in 169 FLT3-ITDmut intermediate cytogenetic risk AML patients with allelic ratio evaluable at diagnosis who achieved first complete remission (CR1) with induction therapy.	27058617
Blindness, Limbal stem cell deficiency	Stem Cell Exhaustion	Corneal blindness due to limbal stem-cell deficiency can be treated by transplantation of cultivated limbal epithelial stem cells (LESCs).	27058829
Liver carcinoma, Specialty Type - cancer, Hollings Cancer Center	Stem Cell Exhaustion	However, the role of miR-452, especially in regulating cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) remains ambiguous.	27058905
Encephalitis, St. Louis	Stem Cell Exhaustion	IFNa, IFNb, IL-12p40, and stem cell factor/c-Kit ligand were increased in SLE patients only (P < 0.05).	27059145
Encephalitis, St. Louis	Stem Cell Exhaustion	ANA-positive healthy individuals exhibit dysregulation in multiple immune pathways yet differ from SLE patients by the absence of elevated IFNs, BLyS, IL-12p40, and stem cell factor/c-Kit ligand.	27059145
Lymphoma	Stem Cell Exhaustion	Efficient Stem Cell Collection after Modified Cisplatin-Based Mobilization Chemotherapy in Patients with Diffuse Large B Cell Lymphoma.	27060439
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	We retrospectively analyzed clinical characteristics, PBSC collection and autologous stem cell transplantation parameters, and hematologic reconstitution data for 65 patients with relapsed or refractory DLBCL who underwent PBSC collection after mobilization with the modified R-DHAP protocol at our institution between 2002 and 2013.	27060439
B-Cell Lymphomas, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	In patients with relapsed or refractory diffuse large B cell lymphoma (DLBCL), R-DHAP (rituximab, dexamethasone, cytarabine, and cisplatin) is a commonly used regimen for salvage therapy and for mobilization of peripheral blood stem cells (PBSCs).	27060439
Acute leukemia	Stem Cell Exhaustion	Factors affecting survival in acute leukemia with donor lymphocyte infusion in the first relapse after allogeneic stem cell transplantation.	27061552
leukemia	Stem Cell Exhaustion	Relapse of leukemia relapsing after allogeneic (allo) stem cell transplantation (SCT) remains an important problem.	27061552
Viremia	Stem Cell Exhaustion	After stem cell transplant (SCT), 48% of patients developed at least 1 episode of viremia.	27061703
Cytomegalovirus Infections, Southern Sotho language, Viremia	Stem Cell Exhaustion	In contrast with SOT patients, where 58/74 (78%) D+R- patients had viremia, a low risk of CMV infection was seen after stem cell transplantation (1/27; 3.7%).	27061703
Specialty Type - cancer, Malignant tumor of colon, Neoplasms, Carcinogenesis	Stem Cell Exhaustion	Multiple stages of carcinogenesis in colon cancer encompass subpopulations of cancer stem cells (CSC), responsible for tumor cell transformation, growth and proliferation.	27062566
PAFAH1B1 wt Allele	Stem Cell Exhaustion	The results indicate that the tumorigenesis of MDS is likely to originate at the stem cell level, suggesting that the WT1 mRNA level measurement in the BM is an effective prognostic marker in patients with MDS.	27062571
Arteriovenous fistula	Stem Cell Exhaustion	The association of endothelial progenitor cell markers with arteriovenous fistula maturation in hemodialysis patients.	27068816
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Evaluations of efficacy of treatment modality in analyses on patients with acute myeloid leukemia (AML) often combine chemotherapy and stem cell transplantation (SCT).	27069151
Secondary malignant neoplasm of liver, Portal vein structure	Stem Cell Exhaustion	Predictive Value of Growth Factors and Interleukins for Future Liver Remnant Volume and Colorectal Liver Metastasis Volume Growth Following Portal Vein Embolization and Autologous Stem Cell Application.	27069178
Inflammation Mediators, Specialty Type - cancer	Stem Cell Exhaustion	Our results suggest that BE columnar epithelial cells with CD133 expression in apical surface undergo inflammation-mediated DNA damage, and mutated cells acquire the property of cancer stem cells with cytoplasmic CD133 expression.	27069317
Inflammation, Tissue damage	Stem Cell Exhaustion	Chronic inflammation and following tissue damage may activate progenitor cells under reactive oxygen/nitrogen species-rich environment.	27069317
Childhood Breast Carcinoma	Stem Cell Exhaustion	In Vitro Effects of Adipose-Derived Stem Cells on Breast Cancer Cells Harvested From the Same Patient.	27070671
Chronic skin ulcer	Stem Cell Exhaustion	Adipose-derived Stem Cells Added to Platelet-rich Plasma for Chronic Skin Ulcer Therapy.	27071140
Liver carcinoma	Stem Cell Exhaustion	Large intergenic non-coding RNA ribonucleic acids-ROR (lincRNA-ROR) has been reported to exert impacts on the maintenance of induced pluripotent stem cells and embryonic stem cells, and play important roles in human hepatocellular cancer.	27071407
Lymphoma	Stem Cell Exhaustion	Outcomes of MYC-associated lymphomas after R-CHOP with and without consolidative autologous stem cell transplant: subset analysis of randomized trial intergroup SWOG S9704.	27072903
Lymphoma	Stem Cell Exhaustion	Double hit lymphoma (DHL) and double protein-expressing (MYC, BCL2) lymphomas (DPL) fare poorly with R-CHOP (rituximab + cyclophosphamide, doxorubicin, vincristine, prednisolone); consolidative autologous stem cell transplant (ASCT) may improve outcomes.	27072903
Hypercholesterolemia	Stem Cell Exhaustion	We demonstrated in experimental studies that hypercholesterolaemia enhances the proliferation of haematopoietic stem cells and the subsequent differentiation to neutrophils, whereas HDL-cholesterol inhibits these processes.	27073920
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Persisting AML blasts became more phenotypically distinct from stem and progenitor cells due to expression of novel marker patterns that differed from pre-treatment AML cells and from all cell types observed in healthy bone marrow.	27074138
Secondary Neoplasm, Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSCs) have gained much attention due to their roles in the invasion and metastasis of numerous kinds of human cancers.	27074560
Hematological Disease	Stem Cell Exhaustion	Cord blood (CB) has been an alternative stem cell source for patients with a wide variety of hematological diseases.	27076239
Graft acceptance	Stem Cell Exhaustion	Although higher rates of engraftment failure as compared to other stem cell sources after cord blood transplantation (CBT) have been a serious concern, the mechanisms underlying these failures have gradually been clarified by analyzing accumulated clinical data, thereby contributing to improvement of engraftment.	27076239
Specialty Type - cancer	Stem Cell Exhaustion	Enrichment of Cells with Cancer Stem Cell-Like Markers in Relapses of Chemoresistant Patients with Locally Advanced Head and Neck Squamous Cell Carcinoma.	27077749
Tissue Engineering	Stem Cell Exhaustion	In Vivo Functional Evaluation of Tissue-Engineered Vascular Grafts Fabricated Using Human Adipose-Derived Stem Cells from High Cardiovascular Risk Populations.	27079751
Huntingtons Disease Pathway	Stem Cell Exhaustion	Manifestation of Huntington's disease pathology in human induced pluripotent stem cell-derived neurons.	27080129
Adult Glioblastoma, Specialty Type - cancer	Stem Cell Exhaustion	Moreover, NUAK2 regulated cancer stem cell (CSC)-related gene expression in the glioblastoma cells.	27081712
leukemia	Stem Cell Exhaustion	Leukemia stem cells are in a hypoxic condition, which induces the expression of HIF-1a.	27082496
Acute lymphocytic leukemia	Stem Cell Exhaustion	Hematopoietic stem cell transplantation for pediatric mature B-cell acute lymphoblastic leukemia with non-L3 morphology and MLL-AF9 gene fusion: three case reports and review of the literature.	27084248
Infancy, Leukocytosis, BCR gene	Stem Cell Exhaustion	All patients achieved complete remission after conventional chemotherapy and subsequently underwent hematopoietic stem cell transplantation as high-risk ALL; patient 3 for infantile ALL with MLL rearrangement and the others for ALL with MLL rearrangement and hyperleukocytosis (white blood cell count at diagnosis >50 x 10(9)/L).	27084248
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	To evaluate the efficacy and feasibility of upfront high-dose chemotherapy (HDCT) and rituximab (R) followed by autologous peripheral blood stem cell transplantation (auto-PBSCT) in patients with newly diagnosed high-intermediate(HI)-, and high(H)-risk diffuse large B-cell lymphoma (DLBCL), we conducted a multicenter prospective phase II trial.	27084252
Toxic effect, Infertility	Stem Cell Exhaustion	Conditioning regimens that include cyclophosphamide (CY) and total body irradiation (TBI) induce severe gonadal toxicity and permanent infertility in approximately 90 % of female patients who undergo hematopoietic stem cell transplantation (HSCT).	27084256
Multiple Myeloma	Stem Cell Exhaustion	A phase II, single-arm, prospective study of bendamustine plus melphalan conditioning for second autologous stem cell transplantation in de novo multiple myeloma patients through a tandem transplant strategy.	27088375
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	This phase II trial evaluates, for the first time, the safety and efficacy of bendamustine plus high-dose melphalan (HDM) as a conditioning regimen before the second autologous stem cell transplantation (ASCT) in previously untreated multiple myeloma (MM) patients.	27088375
Primary Myelofibrosis	Stem Cell Exhaustion	Incidence and risk factors of poor graft function after allogeneic stem cell transplantation for myelofibrosis.	27088376
Primary Myelofibrosis	Stem Cell Exhaustion	Allogeneic hematopoieteic stem cell transplantation (HSCT) is the only curative treatment for myelofibrosis (MF), but it is still associated with significant risks and complications.	27088376
Hematologic Neoplasms, Mycoses	Stem Cell Exhaustion	Association of mannose-binding lectin levels and invasive fungal disease in hematologic malignancy patients receiving myelosuppressive chemotherapy or allogeneic hematopoietic stem cell transplantation.	27088382
Hematologic Neoplasms, Intrinsic Factor Deficiency, Mannose-Binding Protein Deficiency, Mycoses	Stem Cell Exhaustion	In this study, we investigated the association between MBL deficiency and invasive fungal disease (IFD) in hematologic malignancy patients receiving myelosuppressive chemotherapy or hematopoietic stem cell transplant.	27088382
Cardiotoxicity, Childhood Breast Carcinoma	Stem Cell Exhaustion	Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.	27089514
Acute leukemia	Stem Cell Exhaustion	Impact of Donor Epstein-Barr Virus Serostatus on the Incidence of Graft-Versus-Host Disease in Patients With Acute Leukemia After Hematopoietic Stem-Cell Transplantation: A Study From the Acute Leukemia and Infectious Diseases Working Parties of the European Society for Blood and Marrow Transplantation.	27091716
B-Cell Lymphomas	Stem Cell Exhaustion	We describe the rationale and design of the ongoing randomized, active-controlled, multicenter, Phase III study evaluating the efficacy of pixantrone and rituximab versus gemcitabine and rituximab in patients with diffuse large B-cell lymphoma or follicular grade 3 lymphoma, who are ineligible for high-dose chemotherapy and stem cell transplantation, and who failed front-line regimens containing rituximab.	27093976
Malignant Peripheral Nerve Sheath Tumor, Myeloproliferative disease	Stem Cell Exhaustion	Myeloproliferative neoplasms (MPNs) share common clonal stem cells but show significant differences in their clinical courses.	27094255
Eosinophil count raised (finding)	Stem Cell Exhaustion	Retrospective Study of Incidence and Prognostic Significance of Eosinophilia after Allogeneic Hematopoietic Stem Cell Transplantation: Influence of Corticosteroid Therapy.	27094383
Eosinophil count raised (finding)	Stem Cell Exhaustion	The clinical significance of eosinophilia after allogeneic hematopoietic stem cell transplantation is controversial.	27094383
Eosinophil count raised (finding)	Stem Cell Exhaustion	This study aimed to retrospectively study the impact of eosinophilia on the outcome of allogeneic hematopoietic stem cell transplantation by taking into account the influence of corticosteroid therapy.	27094383
Acute lymphocytic leukemia, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We retrospectively studied 204 patients with acute myeloid leukemia, acute lymphoblastic leukemia, and myelodysplastic syndrome who underwent allogeneic hematopoietic stem cell transplantation from January 2001 to December 2010.	27094383
Eosinophil count raised (finding)	Stem Cell Exhaustion	These results suggest that the clinical significance of eosinophilia in patients receiving allogeneic hematopoietic stem cell transplantation should be assessed with consideration of systemic corticosteroid administration.	27094383
Burkitt Lymphoma	Stem Cell Exhaustion	Many studies reported an improved prognosis in patients with Burkitt's lymphoma obviating the need of stem cell transplantation.	27094615
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	The aim of this study is to compare the prognoses of BCL patients with similarly treated and nontransplanted patients with other types of acute lymphoblastic leukemia (ALL) and with ALL patients that underwent allogeneic stem cell transplantation (ASCT) in their first remissions.	27094615
Neutropenia, Acquired Immunodeficiency Syndrome	Stem Cell Exhaustion	Clinical uses of G-CSF includes mobilization of peripheral blood progenitor cells from healthy donors before hematopoietic stem cell transplantation, acceleration of neutrophil recovery following chemotherapy, and in the management of neutropenia due to other causes including AIDS and genetic disorders of granulocyte production.	27094941
Stem Cell Factor	Stem Cell Exhaustion	We analyzed lymph nodes from 22 patients with CHL, of which eight were of the NSCHL and 14 of the non-NSCHL subtype, using immunohistochemical staining of forkhead box P3 (FOXP3), transforming growth factor (TGF)-b, interleukin (IL)-3, IL-13, and stem cell factor (SCF).	27095287
Primary central nervous system lymphoma	Stem Cell Exhaustion	High-dose chemotherapy and autologous stem cell transplant compared with conventional chemotherapy for consolidation in newly diagnosed primary CNS lymphoma--a randomized phase III trial (MATRix).	27098429
X-linked inheritance, Combined immunodeficiency	Stem Cell Exhaustion	Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiency.	27099176
Immune System Diseases	Stem Cell Exhaustion	We used a lentiviral gene therapy approach to treat five SCID-X1 patients with persistent immune dysfunction despite haploidentical hematopoietic stem cell (HSC) transplant in infancy.	27099176
Relapsing course, Central neuroblastoma	Stem Cell Exhaustion	Remission With Donor Lymphocyte Infusion in a Child With Marrow Relapse After Haploidentical Stem Cell Transplantation for Relapsed Stage 4 Neuroblastoma.	27100283
Disseminated neuroblastoma, Bone Marrow Diseases	Stem Cell Exhaustion	A 7-year-old male with Stage 4 neuroblastoma was treated with chemotherapy and autologous hematopoietic stem cell transplantation (HSCT), resulting in partial response with residual bone and marrow disease.	27100283
neurological disability	Stem Cell Exhaustion	The patient received lenalidomide-based chemotherapy and consolidated by autologous stem cell transplantation for his POEMS syndrome, which improved the neurological disability.	27100445
Myeloid-Lymphoid Leukemia Protein	Stem Cell Exhaustion	Maintenance of hematopoietic stem cells and their potential to give rise to progenitors of differentiated lymphoid and myeloid cells are accomplished by a network of regulatory processes.	27100840
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	GABP is necessary for stem/progenitor cell maintenance and myeloid differentiation in human hematopoiesis and chronic myeloid leukemia.	27100840
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Moreover, drastically reduced clonogenic capacity of leukemic stem/progenitor cells isolated from bone marrow aspirates of chronic myeloid leukemia (CML) patients underlines the importance of GABP on stem/progenitor cell maintenance and confirms the relevance of GABP for human myelopoiesis in healthy and diseased states.	27100840
Myeloid	Stem Cell Exhaustion	Ectopic overexpression of a dominant-negative acting GABP mutant led to impaired myeloid differentiation of CD34(+) hematopoietic stem/progenitor cells obtained from healthy donors.	27100840
Childhood Breast Carcinoma	Stem Cell Exhaustion	Correlations were identified between these genes, their expression patterns, and several classical clinical and pathologic parameters, molecular subtypes, and patient outcomes, as well as with proliferation, epithelial-mesenchymal transition, and breast cancer stem cell markers.	27102007
methyldopa, Glaucoma, CTCAE, Retinitis Pigmentosa	Stem Cell Exhaustion	The eye also has many potential target diseases amenable to stem cell-based treatment, such as corneal limbal stem cell deficiency, glaucoma, age-related macular degeneration (AMD), and retinitis pigmentosa (RP).	27102165
Disease	Stem Cell Exhaustion	The recent Zhongshan Ophthalmic Center Ocular Stem Cell Symposium discussed the potential applications of various stem cell types in stem cell-based therapies, drug discoveries and tissue engineering for treating ocular diseases.	27102165
Disease, Degenerative disorder	Stem Cell Exhaustion	Stem cells hold promise for treating a wide variety of diseases, including degenerative disorders of the eye.	27102165
Stargardts disease	Stem Cell Exhaustion	Recent results on the clinical trial of retinal pigment epithelial (RPE) cells from human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) in treating dry AMD and Stargardt's disease in the US, Japan, England, and China have generated great excitement and hope.	27102165
Failure, Acute GVH disease	Stem Cell Exhaustion	Both high and low levels of cellular Epstein-Barr virus DNA in blood identify failure after hematologic stem cell transplantation in conjunction with acute GVHD and type of conditioning.	27102298
Cessation of life, Specialty Type - cancer	Stem Cell Exhaustion	Heterogeneity within each PPCL persisted in culture for the frequency of cells expressing the cancer stem cell markers CD44, CD133, and c-Met and the immunologic markers human leukocyte antigen class II and programmed death ligand 1.	27102771
Bacteremia	Stem Cell Exhaustion	Characteristics comparisons of bacteremia in allogeneic and autologous hematopoietic stem cell-transplant recipients with levofloxacin prophylaxis and influence on resistant bacteria emergence.	27103500
Bacteremia	Stem Cell Exhaustion	The aim of this study was to compare the risk factors and clinical outcomes of bacteremia in allogeneic and autologous hematopoietic stem cell transplant (allo-HSCT and auto-HSCT) recipients with levofloxacin prophylaxis during the early period after transplantation.	27103500
Graft-vs-Host Disease, Lymphoma	Stem Cell Exhaustion	Donor T-cell immune responses can eradicate lymphomas after allogeneic hematopoietic stem cell transplantation (AHSCT), but can also damage healthy tissues resulting in harmful graft-versus-host disease (GVHD).	27103745
Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	Furthermore, inhibition of expression of miR-200c or miR-141 overcomes tumor suppressive effects of PTC-209 including induction of cellular senescence and downregulation of breast cancer stem cell phenotype.	27105531
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Tumor initiating cells (TICs), responsible for tumor initiation, and cancer stem cells (CSCs), responsible for tumor expansion and propagation, are often resistant to chemotherapeutic agents.	27105533
Sarcoma - category (morphologic abnormality), Liposarcoma, Myxoid, Giant cell sarcoma	Stem Cell Exhaustion	To find therapeutic targets against sarcoma initiating and propagating cells we used models of myxoid liposarcoma (MLS) and undifferentiated pleomorphic sarcoma (UPS) developed from human mesenchymal stromal/stem cells (hMSCs), which constitute the most likely cell-of-origin for sarcoma.	27105533
Cessation of life, Traumatic	Stem Cell Exhaustion	Human Traumatic Brain Injury Results in Oligodendrocyte Death and Increases the Number of Oligodendrocyte Progenitor Cells.	27105664
Neoplasms	Stem Cell Exhaustion	Here, we identified the cytokine receptor OSMR as a direct target gene of the transcription factor STAT3 in mouse astrocytes and human brain tumor stem cells (BTSCs).	27110918
Mantle cell lymphoma	Stem Cell Exhaustion	Allogeneic stem cell transplantation for patients with mantle cell lymphoma who failed autologous stem cell transplantation: a national survey of the SFGM-TC.	27111043
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	Poly-chemotherapy plus rituximab followed by autologous stem cell transplantation (auto-SCT) is standard care for untreated young patients with mantle cell lymphoma (MCL).	27111043
Nephroblastoma, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This non-randomized single-center study evaluated medical costs and survival for acute myeloid leukemia between 2005 and 2010 in 50 patients: patients treated with induction and consolidation chemotherapy (ICT) alone; patients treated with ICT plus allogeneic hematopoietic stem cell transplantation (HCT), which is the current preferred post-remission therapy in patients with intermediate- and poor-risk AML with few co-morbidities, and patients treated with ICT plus immunotherapy using autologous dendritic cells (DC) engineered to express the Wilms' tumor protein (WT1).	27111858
methyldopa	Stem Cell Exhaustion	Replacement of diseased RPE with healthy, stem cell-derived RPE is a potential therapeutic strategy for treating AMD.	27112176
Multiple Myeloma	Stem Cell Exhaustion	Rationale and design of the German-Speaking Myeloma Multicenter Group (GMMG) trial ReLApsE: a randomized, open, multicenter phase III trial of lenalidomide/dexamethasone versus lenalidomide/dexamethasone plus subsequent autologous stem cell transplantation and lenalidomide maintenance in patients with relapsed multiple myeloma.	27114074
Primary Myelofibrosis	Stem Cell Exhaustion	A thrombopoietin receptor antagonist is capable of depleting myelofibrosis hematopoietic stem and progenitor cells.	27114459
leukemia	Stem Cell Exhaustion	Bortezomib, Doxorubicin, Cyclophosphamide, Dexamethasone Induction Followed by Stem Cell Transplantation for Primary Plasma Cell Leukemia: A Prospective Phase II Study of the Intergroupe Francophone du Myelome.	27114594
Clinical Observations Supplemental Qualifiers Dataset	Stem Cell Exhaustion	We conducted a prospective phase II trial in patients with pPCL to assess the efficacy of an alternate regimen that combines standard chemotherapy, a proteasome inhibitor, and high-dose melphalan and autologous stem cell transplantation (HDM/ASCT) followed by either allogeneic transplantation or bortezomib/lenalidomide maintenance.	27114594
Retinal Degeneration	Stem Cell Exhaustion	Retinal Structure Measurements as Inclusion Criteria for Stem Cell-Based Therapies of Retinal Degenerations.	27116670
Retinal Diseases	Stem Cell Exhaustion	Treatment Paradigms for Retinal and Macular Diseases Using 3-D Retina Cultures Derived From Human Reporter Pluripotent Stem Cell Lines.	27116668
Macular degeneration	Stem Cell Exhaustion	We discuss the use of pluripotent stem cell lines carrying fluorescent reporters driven by retinal promoters to derive three-dimensional (3-D) retina in culture and how this system can be exploited for elucidating human retinal biology, creating disease models in a dish, and designing targeted drug screens for retinal and macular degeneration.	27116668
Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	All MM cases from 2008 to 2013 were analyzed across 4 risk groups: stem cell transplantation (SCT), hematologic malignancy, solid tumors, and others.	27117516
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We describe the use and outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for multiple myeloma (MM) in Europe between January 1990 and December 2012.	27118410
Lymphoma, Non-Hodgkin, Familial, B-Cell Lymphomas	Stem Cell Exhaustion	Myeloablative autologous hematopoietic stem cell transplantation (HSCT) is a mainstay of therapy for relapsed intermediate-grade B-cell non-Hodgkin lymphoma (NHL); however, relapse rates are high.	27118452
Stable chronic Graft vs Host Disease, Osteoporosis	Stem Cell Exhaustion	We hypothesized that the prevalence of osteoporosis is high in a cohort of 258 patients with moderate to severe cGVHD because of prolonged exposure to risk factors for osteoporosis after allogeneic hematopoietic stem cell transplantation.	27118572
Stable chronic Graft vs Host Disease, Osteoporosis	Stem Cell Exhaustion	The association of higher platelet count in patients with cGVHD and osteoporosis has not been reported previously and represents a new area of interest in the study of osteoporosis after allogeneic hematopoietic stem cell transplantation.	27118572
Lymphoma	Stem Cell Exhaustion	Background This study examined employment patterns and associated factors in lymphoma survivors treated with high-dose chemotherapy with autologous stem cell transplantation (HDT-ASCT) from diagnosis to a follow-up survey at a mean of 10 years after HDT-ASCT.	27123741
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Effectivity of a strategy in elderly AML patients to reach allogeneic stem cell transplantation using intensive chemotherapy: Long-term survival is dependent on complete remission after first induction therapy.	27123833
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Intensive chemotherapy followed by allogeneic stem cell transplantation (alloSCT) can cure AML.	27123833
Cervical Intraepithelial Neoplasia, Granulocyte differentiation, Adult chronic idiopathic neutropenia, Acquired disorder	Stem Cell Exhaustion	Chronic idiopathic neutropenia (CIN) is an acquired disorder of granulopoiesis characterized by increased apoptosis of the bone marrow (BM) granulocytic progenitor cells under the influence of pro-inflammatory mediators and oligoclonal/monoclonal T-lymphocytes.	27124520
Osteosarcoma	Stem Cell Exhaustion	These stem cells and committed osteoblast precursors are the cell of origin in osteosarcoma, and RB1 gene mutations have a strong role in its pathogenesis.	27124644
Muscular Dystrophy, Duchenne	Stem Cell Exhaustion	Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Duchenne Muscular Dystrophy: Safety and Feasibility Study in India.	27125141
Muscular Dystrophy, Duchenne	Stem Cell Exhaustion	Given the regenerative and anti-inflammatory properties of mesenchymal stem cells (MSCs), here we investigated its role in the cellular therapy of DMD patients.	27125141
Malignant neoplasm of stomach	Stem Cell Exhaustion	These 65 had another 4 SNPs associated with gastric cancer susceptibility: PSCA (prostate stem cell antigen) rs2294008, PLCE1 (phospholipase C epsilon 1) rs2274223, PTGER4/PRKAA1 (prostaglandin E receptor 4/ protein kinase AMP-activated catalytic subunit alpha 1) rs13361707, and TYMS (thymidylate synthetase) rs2790.	27127881
Aortic Valve Stenosis	Stem Cell Exhaustion	Dysregulation of ossification-related miRNAs in circulating osteogenic progenitor cells obtained from patients with aortic stenosis.	27129184
Congenital bilateral aplasia of vas deferens	Stem Cell Exhaustion	The present study aimed to determine whether expression of ossification-related miRNAs is related to differentiation intro COPCs (circulating osteogenic progenitor cells) in patients with CAVD.	27129184
Dysgeusia	Stem Cell Exhaustion	Evaluation of the risk factors associated with high-dose chemotherapy-induced dysgeusia in patients undergoing autologous hematopoietic stem cell transplantation: possible usefulness of cryotherapy in dysgeusia prevention.	27129837
Dysgeusia	Stem Cell Exhaustion	The aim of this study was to retrospectively identify the risk factors related with dysgeusia in patients undergoing autologous hematopoietic stem cell transplantation (AHSCT).	27129837
Haiti	Stem Cell Exhaustion	For these reasons, RIT consolidation after chemoimmunotherapy induction has been our standard treatment approach at the University of Rochester for patients with HT who were ineligible for autologous stem cell transplantation.	27130328
Malignant neoplasm of lung	Stem Cell Exhaustion	Polymorphisms of the Stem Cell Marker Gene CD133 and the Risk of Lung Cancer in Chinese Population.	27130457
Tendon Injuries	Stem Cell Exhaustion	Tendon-derived stem cells (TDSCs) are a type of stem cells which may be used in the treatment of tendon injuries.	27130678
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSC) have been observed and isolated from different solid tumours based on the expression of stem cell markers.	27131799
Aggressive behavior	Stem Cell Exhaustion	The stem cell markers CD44, Bmi1, Oct4 and Nanog are frequently expressed in MEC in relation to normal salivary gland and Oct4 and Nanog expression may contribute to aggressiveness and worst prognosis in MEC patients.	27131799
Perineural spread, Mucoepidermoid carcinoma of salivary gland	Stem Cell Exhaustion	Embryonic stem cells markers Oct4 and Nanog correlate with perineural invasion in human salivary gland mucoepidermoid carcinoma.	27131799
Primary central nervous system lymphoma	Stem Cell Exhaustion	In this trial, we addressed the tolerability and efficacy of adding rituximab with or without thiotepa to methotrexate-cytarabine combination therapy (the MATRix regimen), followed by a second randomisation comparing consolidation with whole-brain radiotherapy or autologous stem cell transplantation in patients with primary CNS lymphoma.	27132696
Whole brain radiation therapy	Stem Cell Exhaustion	Patients with responsive or stable disease after the first stage were then randomly allocated between whole-brain radiotherapy and autologous stem cell transplantation.	27132696
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	The variant isoforms of CD44 (CD44v), which has been associated with treatment resistance and tumor recurrence, are contributed to the feature of some of the new cell surface markers for cancer stem cells.	27133224
Cachexia, Muscular Atrophy	Stem Cell Exhaustion	By using transcriptomics and cytokine profiling of human muscle stem cell-based models and human cancer-induced cachexia models in mice, we found that cachectic cancer cells secreted many inflammatory factors that rapidly led to high levels of fatty acid metabolism and to the activation of a p38 stress-response signature in skeletal muscles, before manifestation of cachectic muscle atrophy occurred.	27135739
Neoplasms	Stem Cell Exhaustion	Tumor stem cells have been found in a variety of neoplasms and stated to have a role in tumor progression.	27136105
Procedures on Peripheral Nervous System, Globoid cell leukodystrophy	Stem Cell Exhaustion	Evaluation of Krabbe disease burden and eligibility for hematopoietic stem cell transplantation are often based on neuroimaging findings using the modified Loes scoring system, which encompasses central but not peripheral nervous system changes.	27137647
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)	Stem Cell Exhaustion	This study aims to investigate the expression of CK15 and CK19 as possible stem cell markers in vitiligo during phototherapy.	27139521
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)	Stem Cell Exhaustion	This expression of cytokeratins was significantly correlated to improvement and can be considered valuable tool to monitor stem cells stimulation for the sake of the repigmentation process in vitiligo.	27139521
Neoplasms	Stem Cell Exhaustion	Ganglioneuromas are rare, benign neoplasms derived from sympathetic neural crest progenitor cells.	27140023
Amyloidosis	Stem Cell Exhaustion	Stem cell transplantation compared with melphalan plus dexamethasone in the treatment of immunoglobulin light-chain amyloidosis.	27142462
Primary amyloidosis	Stem Cell Exhaustion	Autologous stem cell transplantation (SCT) is a common management strategy for select patients with immunoglobulin light-chain amyloidosis, but no trials have documented improved overall survival.	27142462
Encephalomyelitis, Acute Disseminated, Neurologic Symptoms	Stem Cell Exhaustion	Seven years after disease onset, the patient developed severe neurological symptoms resembling acute disseminated encephalomyelitis, prompting allogeneic hematopoietic stem cell transplantation (HSCT) with the HLA-identical mother as donor.	27146671
Malignant Neoplasms	Stem Cell Exhaustion	Children were eligible if they were <22 years old and had a high-risk malignancy, recurrence, or required hematopoietic stem cell transplantation (HSCT).	27148856
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	The clonally expansion of an abnormal pluripotent hematopoetic stem cell could be responsible for both, PV and DLBCL.	27151728
Embryonic Mosaic	Stem Cell Exhaustion	Personalized Stem Cell Therapy to Correct Corneal Defects Due to a Unique Homozygous-Heterozygous Mosaicism of Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome.	27151912
ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 1	Stem Cell Exhaustion	This study supports the rationale for the development of cultured autologous oral mucosal epithelial stem cell sheets obtained by selected heterozygous R311K-p63 stem cells, as an effective and personalized therapy for reconstructing the ocular surface of this unique case of EEC syndrome, thus bypassing gene therapy approaches.	27151912
Corneal degeneration	Stem Cell Exhaustion	No definitive treatments are available to counteract and resolve the progressive corneal degeneration due to a premature aging of limbal epithelial stem cells.	27151912
Somatic mosaicism	Stem Cell Exhaustion	A detailed analysis of the degree of somatic mosaicism in leukocytes from peripheral blood and oral mucosal epithelial stem cells (OMESCs) from biopsies of buccal mucosa showed that approximately 80% were homozygous mutant cells and 20% were heterozygous.	27151912
Rudiger syndrome 1	Stem Cell Exhaustion	The heterozygous mutant R311K-p63 stem cells can be isolated by means of clonal analysis and given their good regenerative capacity, they may be used to successfully correct the corneal defects present in this unique case of ectrodactyly-ectodermal dysplasia-clefting syndrome.	27151912
Congenital Heart Defects	Stem Cell Exhaustion	Stem cell therapy for children with congenital heart defects is moving forward, with several completed and ongoing clinical trials.	27151913
Heart failure	Stem Cell Exhaustion	Age-Dependent Effect of Pediatric Cardiac Progenitor Cells After Juvenile Heart Failure.	27151913
Heart failure	Stem Cell Exhaustion	Here we investigate the role of age of human pediatric cardiac progenitor cells (hCPCs) on ventricular remodeling in a model of juvenile heart failure.	27151913
Heart failure	Stem Cell Exhaustion	This study using human cardiac progenitor cells shows age-related changes in the reparative ability of cells in a model of pediatric heart failure and uses computational and systems biology to elucidate potential mechanisms.	27151913
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease, Periodicity	Stem Cell Exhaustion	Two-hundred and sixty-nine females aged <=42 and undergoing an allogeneic stem cell transplant were retrospectively studied to assess the effect of age, conditioning regimen and chronic graft-versus-host disease (cGVHD) on resumption of stable menstrual cyclicity.	27153290
Skeletal muscle atrophy	Stem Cell Exhaustion	Expression of a klotho transgene in mdx mice restored their longevity, reduced muscle wasting, improved function and greatly increased the pool of muscle-resident stem cells required for regeneration.	27154199
Lung Injury	Stem Cell Exhaustion	Proteome Profiling in Lung Injury after Hematopoietic Stem Cell Transplantation.	27155584
Pulmonary Complication, Communicable Diseases, Lung Injury, Idiopathic pneumonia syndrome	Stem Cell Exhaustion	Pulmonary complications due to infection and idiopathic pneumonia syndrome (IPS), a noninfectious lung injury in hematopoietic stem cell transplant (HSCT) recipients, are frequent causes of transplantation-related mortality and morbidity.	27155584
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	In seven patients, more than two (2-6) different therapies were registered; four were exposed to fludarabine-based therapy, three to radiotherapy and two to autologous stem-cell transplantation, and in the RIT cohort, two patients developed myelodysplastic syndrome.	27157440
Cryptococcus, Injury of kidney	Stem Cell Exhaustion	Disseminated cryptococcal infection in allogeneic stem cell transplant patients: a rare cause of acute kidney injury.	27159179
Hematological Disease	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) can be lifesaving for some of the deadliest hematologic diseases.	27159179
Epithelial ovarian cancer, Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	To investigate the role of cancer stem cell marker CD44 variant 6 in the development of distant metastasis in patients with epithelial ovarian cancer.	27159753
Childhood Craniopharyngioma, Pituitary Adenoma	Stem Cell Exhaustion	Differential Expression of Stem Cell Markers in Human Adamantinomatous Craniopharyngioma and Pituitary Adenoma.	27161333
Pituitary Adenoma	Stem Cell Exhaustion	Our aim was to characterize the expression pattern of ABCG2, CD44, DLL4, NANOG, NOTCH2, POU5F1/OCT4, SOX2, and SOX9 stem cell markers in human ACP and pituitary adenoma.	27161333
Adenoma, Pituitary Neoplasms, American College of Physicians	Stem Cell Exhaustion	Our results confirm the presence of stem cell markers in human pituitary tumours as well as the different expression patterns of ACP and adenoma.	27161333
American College of Physicians	Stem Cell Exhaustion	Adamantinomatous CP (ACP) was associated with an activating mutation in b-catenin, and it has been postulated that pituitary stem cells might play a role in oncogenesis in human ACP.	27161333
Pituitary Adenoma	Stem Cell Exhaustion	Stem cells have also been identified in pituitary adenoma.	27161333
Liver carcinoma, Neoplasms	Stem Cell Exhaustion	Immunohistochemical study of hepatocyte, cholangiocyte and stem cell markers of hepatocellular carcinoma: the second report: relationship with tumor size and cell differentiation.	27161394
Liver carcinoma, HCCS gene, Neoplasms	Stem Cell Exhaustion	The purpose of this study is to investigate whether ordinary hepatocellular carcinomas (HCCs) show positivity of stem/progenitor cell markers and cholangiocyte markers during the process of tumor progression.	27161394
Hollings Cancer Center	Stem Cell Exhaustion	Ninety-four HCC lesions no larger than 8 cm from 94 patients were immuno-histochemically studied using two hepatocyte markers (Hep par 1 and a-fetoprotein), five cholangiocyte markers (cytokeratin CK7, CK19, Muc1, epithelial membrane antigen and carcinoembryonic antigen) and three hepatic stem/progenitor cell markers (CD56, c-Kit and EpCAM).	27161394
Neoplasms	Stem Cell Exhaustion	The positive ratios of stem/progenitor cell markers tended to be higher in larger sized and more poorly differentiated tumors (except for c-Kit).	27161394
Hollings Cancer Center, Neoplasms	Stem Cell Exhaustion	Ordinary HCC can acquire the characteristic of positivity of cholangiocyte and stem/progenitor cell markers during the process of tumor progression.	27161394
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	High-dose melphalan 200 mg/m(2) (MEL 200) is the standard of care as a conditioning regimen for autologous hematopoietic stem cell transplantation (AHSCT) for multiple myeloma (MM).	27164062
Herpes Simplex Infections	Stem Cell Exhaustion	Complex management of resistant oral herpes simplex virus infection following hematopoietic stem cell transplantation: potential role of topical cidofovir.	27165053
Herpes Simplex Infections, Simplexvirus, Communicable Diseases	Stem Cell Exhaustion	Herpes simplex virus (HSV) infection commonly occurs during the immunosuppression associated with hematopoietic stem cell transplantation (HSCT).	27165053
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Leukemic stem cell persistence in chronic myeloid leukemia patients in deep molecular response induced by tyrosine kinase inhibitors and the impact of therapy discontinuation.	27167108
Aplastic Anemia, Communicable Diseases	Stem Cell Exhaustion	[Successful treatment of an overwhelming infection with granulocyte transfusion in severe aplastic anemia patient undergoing allogeneic peripheral blood stem cell transplantation].	27169447
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We tested the hypothesis that proliferative activity of hematopoietic stem cells has impact on survival in newly diagnosed patients with myelodysplastic syndrome (MDS) and secondary acute myeloid leukemia (AML).	27170453
Simian immunodeficiency virus	Stem Cell Exhaustion	Initiation of Antiretroviral Therapy Restores CD4+ T Memory Stem Cell Homeostasis in Simian Immunodeficiency Virus-Infected Macaques.	27170752
SLITRK1 wt Allele, Acupuncture and Oriental Medicine, Memory	Stem Cell Exhaustion	T memory stem cells (TSCM) are a unique memory T cell subset with enhanced self-renewal capacity and the ability to differentiate into other memory T cell subsets, such as central and transitional memory T cells (TCM and TTM, respectively).	27170752
Glioblastoma Multiforme Pathway, Neoplasms	Stem Cell Exhaustion	Glioma Cells in the Tumor Periphery Have a Stem Cell Phenotype.	27171431
Glioma, Neoplasms	Stem Cell Exhaustion	The results showed that tumor cells in the periphery of patient gliomas expressed stem cell markers, however for most markers at a significantly lower level than in the tumor core.	27171431
Glioma, Neoplasms	Stem Cell Exhaustion	In conclusion tumor cells in the periphery of patient gliomas have a stem cell phenotype, although it is less pronounced than in the tumor core.	27171431
Adult Glioblastoma	Stem Cell Exhaustion	Migrating cells in orthotopic glioblastoma xenografts preserve expression and stem cell markers.	27171431
Retinitis Pigmentosa	Stem Cell Exhaustion	A retrospective case report of a retinitis pigmentosa patient who underwent vitrectomy for epiretinal membrane after intravitreal autologous stem cell implantation.	27171917
Acute lymphocytic leukemia	Stem Cell Exhaustion	Phase 2 study of intensified chemotherapy and allogeneic hematopoietic stem cell transplantation for older patients with acute lymphoblastic leukemia.	27171984
Toxoplasmosis	Stem Cell Exhaustion	A matched case-control study of toxoplasmosis after allogeneic haematopoietic stem cell transplantation: still a devastating complication.	27172809
Toxoplasmosis	Stem Cell Exhaustion	Toxoplasmosis (TXP) is a life-threatening complication of allogeneic haematopoietic stem cell transplantation (AHSCT).	27172809
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	The CXCL12/CXCR4 axis is involved in regulation of proliferation, survival and trafficking of hematopoietic stem cells, including B lymphocytes and disruption within this signaling pathway has been implicated in pathogenesis of chronic lymphocytic leukemia (CLL).	27173875
Acute GVH disease	Stem Cell Exhaustion	Administration of 81 mesenchymal stromal cell end-products to 26 patients with severe steroid-resistant acute graft-versus-host disease in 7 stem cell transplant centers who were refractory to many lines of treatment, induced a 77% overall response at the primary end point (day 28).	27175026
Chromosome Aberrations	Stem Cell Exhaustion	Autologous stem cell transplantation could improve, but not overcome the adverse prognostic effect of high-risk cytogenetic abnormalities.	27175647
Specialty Type - cancer	Stem Cell Exhaustion	The benchmarking of the experimental data with the clinical course highlights that patients with prevalence of circulating cancer stem cells (CD45(neg)CD133(pos)) have a lower overall survival.	27176720
leukemia	Stem Cell Exhaustion	ABCG2, Cytogenetics, and Age Predict Relapse after Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia in Complete Remission.	27178373
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Few data are available in patients with AML undergoing allogeneic stem cell transplantation (SCT), particularly when in complete remission (CR).	27178373
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Significant morbidity and mortality was observed among hematopoietic stem cell transplant patients (7.3%, 60-day mortality), solid organ transplant patients (13.3%, 60-day mortality), and COPD patients (12.8%, 60-day mortality).	27179369
Secondary Neoplasm, Malignant Neoplasms	Stem Cell Exhaustion	Bmi-1 acts as an oncogene by controlling cell cycle and self-renewal of adult stem cells, and its overexpression correlates with metastasis and poor prognosis in several cancers.	27180058
Tumor necrosis	Stem Cell Exhaustion	Relative to OLHDF, HFR was associated with greater indoxyl sulfate removal and lesser abnormalities in all other study variables, namely circulating interleukin-6, tumor necrosis factor-alpha, proportions of activated proinflammatory (CD14+CD16+, CD14++CD16+) monocytes, endothelial progenitor cells, apoptotic endothelial microparticles, vascular endothelial growth factor, vascular cellular adhesion molecule, angiopoietins 2 and 1, annexin V, and superoxide dismutase.	27182679
Multiple Myeloma	Stem Cell Exhaustion	We evaluated the impact of RI on outcomes of patients with multiple myeloma treated with melphalan 200 mg/m2 (Mel200) and autologous stem cell transplantation.	27183094
Specialty Type - cancer, REG1CP gene, Multiple Myeloma	Stem Cell Exhaustion	We analysed relative survival (RS) of patients diagnosed in 1998-2011 and treated with ASCT within 12 months after diagnosis in Germany (n = 3591; German Registry of Stem Cell Transplantation) and compare RS with survival of myeloma patients diagnosed in the same years in Germany (n = 13,903; population-based German Cancer Registries).	27185572
Mucopolysaccharidosis II	Stem Cell Exhaustion	X-Chromosome Inactivation Analysis in Different Cell Types and Induced Pluripotent Stem Cells Elucidates the Disease Mechanism in a Rare Case of Mucopolysaccharidosis Type II in a Female.	27187040
Childhood Non-Hodgkin Lymphoma, Relapsing course	Stem Cell Exhaustion	Comparison of Total Body Irradiation (TBI) Conditioning with Non-TBI for Autologous Stem Cell Transplantation in Newly Diagnosed or Relapsed Mature T- and NK-Cell Non-Hodgkin Lymphoma.	27188204
Toxic effect, Lymphoma	Stem Cell Exhaustion	This retrospective study was conducted for comparison of survival outcomes and toxicities of autologous stem cell transplantation (ASCT) based on the use of total body irradiation (TBI) as a part of the conditioning regimen in patients with mature T- and natural killer (NK)-cell lymphomas.	27188204
Embryonic Mosaic, Hereditary Diffuse Leukoencephalopathy with Spheroids	Stem Cell Exhaustion	Our findings suggest that expression of wild-type CSF1R in some cells, whether achieved by mosaicism or chimerism, may confer benefit in hereditary diffuse leukoencephalopathy with axonal spheroids and suggest that haematopoietic stem cell transplantation might have a therapeutic role for this disorder.	27190017
Liver carcinoma	Stem Cell Exhaustion	De novo HAPLN1 expression hallmarks Wnt-induced stem cell and fibrogenic networks leading to aggressive human hepatocellular carcinomas.	27191501
Aggressive course	Stem Cell Exhaustion	Both networks were linked by Hyaluronan And Proteoglycan Link Protein 1 (HAPLN1), that appeared de novo in aggressive HCCs expressing cytoplasmic b-catenin and stem cell markers.	27191501
Liver carcinoma, HCCS gene, Hollings Cancer Center	Stem Cell Exhaustion	About 20% hepatocellular carcinomas (HCCs) display wild-type b-catenin, enhanced Wnt signaling, hepatocyte dedifferentiation and bad outcome, suggesting a specific impact of Wnt signals on HCC stem/progenitor cells.	27191501
Peripheral Blood Stem Cells, PAFAH1B1 wt Allele	Stem Cell Exhaustion	A 17-year-old patient was diagnosed with MDS and required initiation of peripheral blood stem cell transplantation within a maximum of 3 weeks and was in the luteal phase of the menstrual cycle when the possibility of attempting preservation of fertility was presented to her.	27191608
Necrosis, Adult Glioblastoma	Stem Cell Exhaustion	Transforming growth factor-b and stem cell markers are highly expressed around necrotic areas in glioblastoma.	27193555
Necrosis	Stem Cell Exhaustion	In addition, the stem cell markers CD133 and alkaline phosphatase (ALPL) were also highly expressed around necrotic foci in GBM tissues.	27193555
Hypoxia	Stem Cell Exhaustion	These results collectively support the hypothesis that tissue hypoxia induces the stem cell phenotype through TGF-b-related EMT and contributes to the poor outcome of GBM patients.	27193555
Degenerative polyarthritis	Stem Cell Exhaustion	We sought to establish the in-vivo immune response in collagenase-induced OA and investigate the ability of human mesenchymal stem cells (hMSCs) overexpressing viral interleukin 10 (vIL-10) to modulate immune populations and delay/prevent disease progression.	27194025
Carcinosarcoma, Carcinoma, Spindle-Cell	Stem Cell Exhaustion	We believe trichoblastic carcinosarcoma is an authentic carcinosarcoma derived from multiple progenitor cells whereas epidermal carcinosarcomas are derived from a single progenitor cell that undergoes epithelial to mesenchymal transition, and are better considered as sarcomatoid carcinomas.	27194674
Wasting, Antilymphocyte Serum	Stem Cell Exhaustion	Our results on Pax7 and MyoD protein expression suggest that proliferation and differentiation of skeletal muscle stem cells are affected in ALS patients, and the myogenic processes cannot overcome the denervation-induced wasting.	27195289
Specialty Type - cancer	Stem Cell Exhaustion	However, a recent study has been interpreted to suggest that random mutations during stem cell divisions are the major contributor to human cancer.	27196525
Vestibular Diseases	Stem Cell Exhaustion	Regenerative therapy for vestibular disorders using human induced pluripotent stem cells (iPSCs): neural differentiation of human iPSC-derived neural stem cells after in vitro transplantation into mouse vestibular epithelia.	27196942
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Unrelated donors are associated with improved relapse-free survival compared to related donors in patients with myelodysplastic syndrome undergoing reduced intensity allogeneic stem cell transplantation.	27197602
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Reduced intensity allogeneic stem cell transplantation (RI alloSCT) is a potentially curative treatment approach for patients with myelodysplastic syndrome (MDS).	27197602
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Exercise-induced endothelial progenitor cell mobilization is attenuated in impaired glucose tolerance and type 2 diabetes.	27197857
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPCs) contribute to vascular homeostasis and are fewer in those with type 2 diabetes mellitus (T2DM) compared with normal glucose tolerance (NGT), suggesting a link between EPCs and T2DM-associated vasculopathies.	27197857
Morular Metaplasia of the Endometrium, Malignant Neoplasms, Multiple Myeloma	Stem Cell Exhaustion	Aldehyde dehydrogenase (ALDH) is highly active in physiological stem cells as well as in tumor-initiating cells of some malignancies including multiple myeloma (MM).	27199264
Toxoplasmosis	Stem Cell Exhaustion	After a cluster of fatal toxoplasmosis among stem cell transplant recipients at 2 hospitals, surveillance with polymerase chain reaction (PCR) (blood) was instituted.	27199460
Lymphoma, Follicular, Lymphoma	Stem Cell Exhaustion	Prognostic impact of history of follicular lymphoma, induction regimen and stem cell transplant in patients with MYC/BCL2 double hit lymphoma.	27203548
Sepsis, Hematological Disease, Malignant Neoplasms	Stem Cell Exhaustion	The current quality improvement project embedded sepsis best practices into routine care for ambulatory clinic patients receiving chemotherapy or undergoing hematopoietic stem cell transplantation for hematologic disease or malignancies.	27206294
Scleromyxedema	Stem Cell Exhaustion	High-dose melphalan with autologous stem cell transplantation appears to be a safe and effective long-term treatment in patients with scleromyxedema.	27207484
physiopathological, Metabolic Diseases, Peripheral Arterial Diseases	Stem Cell Exhaustion	Plasma Levels of Proprotein Convertase Subtilisin/Kexin Type 9 Are Elevated in Patients With Peripheral Artery Disease and Associated With Metabolic Disorders and Dysfunction in Circulating Progenitor Cells.	27207972
Hepatobiliary System, Choledocholithiasis, Venoocclusive disease, Cholecystitis, Graft-vs-Host Disease, Cholangitis	Stem Cell Exhaustion	To determine whether gallbladder sonographic findings in hematopoietic stem cell (HSC) transplant patients can distinguish among hepatobiliary complications of HSC transplants (graft-versus-host disease [GVHD] and veno-occlusive disease) and biliary events (cholecystitis, cholangitis, and choledocholithiasis).	27208200
Rheumatoid Arthritis, Inflammation	Stem Cell Exhaustion	Arterial wall inflammation, bone marrow and splenic activity (index of progenitor cell activity) was assessed with (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) in RA patients in remission (disease activity score (DAS28) <2.6 for >6 months) and healthy controls.	27209093
Restenosis	Stem Cell Exhaustion	The Combo stent combines an abluminal biodegradable coating eluting sirolimus and a luminal anti-CD34(+) antibody layer to attract endothelial progenitor cells in order to promote vessel healing, thus preventing neointima formation and restenosis.	27209254
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Outcomes for patients with multiple myeloma (MM) have improved in recent years owing to use of novel agents and high-dose therapy followed by autologous stem cell transplant (ASCT).	27211270
Weight decreased	Stem Cell Exhaustion	Weight Loss Upregulates the Small GTPase DIRAS3 in Human White Adipose Progenitor Cells, Which Negatively Regulates Adipogenesis and Activates Autophagy via Akt-mTOR Inhibition.	27211557
Clostridium difficile colitis	Stem Cell Exhaustion	Fecal microbiota transplantation for recurrent Clostridium difficile infection in hematopoietic stem cell transplant recipients.	27214585
Clostridium difficile colitis, Central Diabetes Insipidus, Intestinal dysbiosis	Stem Cell Exhaustion	Recurrent Clostridium difficile infection (CDI) is a consequence of intestinal dysbiosis and is particularly common following hematopoietic stem cell transplantation (HSCT).	27214585
Injury of kidney	Stem Cell Exhaustion	Effects of CYP3A5 polymorphism on the pharmacokinetics of a once-daily modified-release tacrolimus formulation and acute kidney injury in hematopoietic stem cell transplantation.	27217047
Osteoarthritis, Knee	Stem Cell Exhaustion	Although this phase I study included a limited number of patients without a placebo arm, it showed that local injection of autologous adipose-derived stem cells was safe and well tolerated in patients with knee osteoarthritis.	27217345
Degenerative disorder	Stem Cell Exhaustion	This information can be used in future studies to potentially enhance or predict responses to hNPC and other stem cell therapies for retinal degenerative diseases.	27217715
Unspecified visual loss	Stem Cell Exhaustion	Although treatment options for RDDs are limited, stem and progenitor cell-based therapies have great potential to halt or slow the progression of vision loss.	27217715
Retinal Degeneration	Stem Cell Exhaustion	Gene expression changes in the retina following subretinal injection of human neural progenitor cells into a rodent model for retinal degeneration.	27217715
Behavioral Symptoms Index Composite Score (BASC-2), Infection of bloodstream	Stem Cell Exhaustion	Bloodstream infections (BSI) are frequent and potentially severe complications in allogeneic hematopoietic stem cell transplant (AHSCT) recipients.	27218243
Pertussis, Specialty Type - cancer, Pneumonia	Stem Cell Exhaustion	We illustrate 2 cases of pneumonia associated with Bordetella pertussis infection in 72-year-old and 61-year-old patients with cancer receiving myelosuppressive therapy after hematopoietic stem cell transplantation.	27218794
Bacterial Infections, Specialty Type - cancer	Stem Cell Exhaustion	Bacterial infections are a significant cause of morbidity and mortality in patients with cancer, and those receiving hematopoietic stem cell transplant, solid organ transplant, or myelosuppressive therapy are at increased risk.	27218794
Toxic effect, Multiple Myeloma	Stem Cell Exhaustion	Effect of melphalan 140 mg/m(2) vs 200 mg/m(2) on toxicities and outcomes in multiple myeloma patients undergoing single autologous stem cell transplantation-a single center experience.	27219740
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Although melphalan at a dose of 140 mg/m(2) (MEL140) is an acceptable conditioning regimen for autologous stem cell transplantation (ASCT) in multiple myeloma (MM) patients, very few studies compared it to the most commonly used dose of 200 mg/m(2) (MEL200).	27219740
Diabetic Foot	Stem Cell Exhaustion	Clinical Evaluation of Human Umbilical Cord Mesenchymal Stem Cell Transplantation After Angioplasty for Diabetic Foot.	27219884
Ulcer	Stem Cell Exhaustion	Aims: The multilineage differentiation potential of human umbilical cord mesenchymal stem cells (HUCMSCs) holds therapeutic promise for non-healing ulcers and tissue regeneration.	27219884
Graft-vs-Host Disease	Stem Cell Exhaustion	Because CCR4 is expressed on normal regulatory T cells as well as on ATLL cells, MOG may accelerate graft-versus-host disease (GVHD) by eradicating regulatory T cells in patients with allogeneic hematopoietic stem cell transplantation (allo-HSCT).	27220263
Unknown (origin) (qualifier value), palladium	Stem Cell Exhaustion	Additionally, idiopathic PD but not LRRK2-associated PD patients showed increased levels of the pro-inflammatory marker interleukin-12-p40 as well as the anti-inflammatory species interleukin-10, brain-derived neurotrophic factor, and stem cell factor.	27220776
neurological complication	Stem Cell Exhaustion	Neurological complications (NC) after hematopoietic stem cell transplantation (HSCT) are rare events.	27222935
Cytomegalovirus Infections	Stem Cell Exhaustion	Cytomegalovirus infection in autologous stem cell transplant recipients in the era of rituximab.	27225264
Malignant Neoplasms	Stem Cell Exhaustion	This clinical-grade platform provides the basis for a phase 1 trial evaluating the activity of CD19-CAR-modified CD8(+) TSCM in patients with B-cell malignancies refractory to prior allogeneic hematopoietic stem cell transplantation.	27226436
Neoplasms	Stem Cell Exhaustion	Long-lived, self-renewing, multipotent T memory stem cells (TSCM) can trigger profound and sustained tumor regression but their rareness poses a major hurdle to their clinical application.	27226436
Multiple Myeloma	Stem Cell Exhaustion	Although allogeneic stem cell transplantation is not a standard therapy for multiple myeloma, some patients can benefit from this intense therapy.	27229716
Primary Myelofibrosis	Stem Cell Exhaustion	Serial 18F-FDG PET for Monitoring Treatment Response After Allogeneic Stem Cell Transplantation for Myelofibrosis.	27230931
Primary Myelofibrosis	Stem Cell Exhaustion	Our objective was to assess the feasibility of 18F-FDG PET/CT for noninvasive monitoring of treatment response after allogeneic stem cell transplantation (SCT) for myelofibrosis.	27230931
melphalan/prednisone protocol	Stem Cell Exhaustion	Therefore, we studied effect of LVAD on three circulating vascular biomarkers: stem cells (SC), endothelial progenitor cells (EPC) and microparticles (MP).	27232919
Central neuroblastoma	Stem Cell Exhaustion	Individuals eligible for our cohort were aged <20 yr when diagnosed with high-risk neuroblastoma and received cancer-directed therapy including stem cell transplantation at Hospital de Ninos Sor Maria Ludovica between February 1999 and February 2015.	27235336
Hematologic Neoplasms	Stem Cell Exhaustion	Autologous haematopoietic progenitor cell (HPC) transplantation is indicated to treat some haematological malignancies.	27237104
Pleural effusion disorder	Stem Cell Exhaustion	Incidence, etiology, and outcome of pleural effusions in allogeneic hematopoietic stem cell transplantation.	27238902
Pleural effusion disorder, Pleural Effusion, CTCAE	Stem Cell Exhaustion	Pleural effusion is a known entity in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT); however, the incidence, risk factors, and morbidity-mortality outcomes associated with pleural effusions remain unknown.	27238902
Acute GVH disease, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Increase of endothelial progenitor cells in acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia.	27239737
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	47 patients with acute myeloid leukaemia (AML) who were in complete remission as they underwent allogeneic hematopoietic stem cell transplantation with myeloablative conditioning with PBSC as stem cell source were enrolled in the study.	27239737
Graft-vs-Host Disease, Acute GVH disease, Endothelial dysfunction	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPCs; CD31+ CD34(bright)CD133+ CD45(dim) cells) are novel markers of endothelial dysfunction and related to inflammatory processes such as acute graft-versus-host disease (aGvHD).	27239737
leukemia	Stem Cell Exhaustion	Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) is considered the mainstay of the treatment for both subtypes of leukemia due to their refractoriness to chemotherapy and high rates of relapse, it remains unclear whether allo-HSCT is curative in such cases due to their scarcity.	27244257
Specialty Type - cancer	Stem Cell Exhaustion	The Distribution of Human Stem Cell-like Memory T Cell in Lung Cancer.	27244531
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation remains important in the treatment of myeloma and relapsed lymphoma.	27245311
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	A total of 277 patients with myeloma and lymphoma had stem cell mobilization; 97.5% were successfully mobilized, including 41.5% who received plerixafor.	27245311
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Rescue plerixafor was more effective in patients with myeloma than lymphoma as after 1 dose of plerixafor; 85% versus 55% collected a minimum number of stem cells (2 x 10E6 CD34 cells/kg) for 1 transplant and 51% versus 15% collected > 5 x 10E6 CD34 cells/kg.	27245311
Nerve Degeneration	Stem Cell Exhaustion	More recently, efforts have shifted to the development of a more accurate model to decipher the precise mechanisms of neurodegeneration, using induced pluripotent stem cells derived from SA SCA7 patients.	27245542
Multiple Sclerosis	Stem Cell Exhaustion	A cohort of patients with poor-prognosis multiple sclerosis (MS) underwent chemotherapy-based immune ablation followed by immune reconstitution with an autologous hematopoietic stem cell transplant (IA/aHSCT).	27246142
Cessation of life	Stem Cell Exhaustion	Late Mortality and Causes of Death among Long-Term Survivors after Allogeneic Stem Cell Transplantation.	27246369
Cessation of life	Stem Cell Exhaustion	We sought to assess the late mortality risks and causes of death among long-term survivors of allogeneic hematopoietic stem cell transplantation (HCT).	27246369
Observation of attack, Bone marrow hypocellularity	Stem Cell Exhaustion	These data suggest that HLA-LLs are a useful marker of the presence of immune pathophysiology in AA and that T-cell attacks against hematopoietic progenitor cells, rather than against hematopoietic stem cells, can trigger bone marrow failure in AA patients.	27250585
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	The most ubiquitous, CD44 standard, has been used as a cancer stem cell marker in ovarian and other cancers.	27253518
Diabetes	Stem Cell Exhaustion	The mobilization of hematopoietic stem cells (HSCs) and EPCs in response to G-CSF is impaired by diabetes, owing to CXCL12 dysregulation.	27255499
Diabetes	Stem Cell Exhaustion	We re-analysed data gathered in the NCT02056210 trial, wherein patients with (n = 10) and without diabetes (n = 10) received plerixafor to test stem/progenitor cell mobilization.	27255499
Diabetes Mellitus	Stem Cell Exhaustion	Diabetes damages the endothelium and reduces the availability of bone marrow (BM)-derived endothelial progenitor cells (EPCs).	27255499
Tissue damage	Stem Cell Exhaustion	After birth, tissue stem cells maintain properly functioning tissues and organs under homeostasis as well as promote regeneration after tissue damage or injury.	27256386
Cerebrovascular accident	Stem Cell Exhaustion	Clinical Outcomes of Transplanted Modified Bone Marrow-Derived Mesenchymal Stem Cells in Stroke: A Phase 1/2a Study.	27256670
Cerebrovascular accident	Stem Cell Exhaustion	Eighteen patients with stable, chronic stroke were enrolled in a 2-year, open-label, single-arm study to evaluate the safety and clinical outcomes of surgical transplantation of modified bone marrow-derived mesenchymal stem cells (SB623).	27256670
Amyloidosis	Stem Cell Exhaustion	This long-term follow-up study aimed to assess the prognosis of systemic light chain amyloidosis (AL) patients treated with high-dose melphalan (HDM) chemotherapy and autologous stem cell transplantation, depending on iFISH results.	27257181
Diffuse alveolar hemorrhage, Vasculitis, Pulmonary Complication	Stem Cell Exhaustion	The diffuse alveolar hemorrhage (DAH) syndrome is a life-threatening pulmonary complication related to systemic vasculitides, posthematopoietic stem cell transplantation, drugs, or toxins.	27261934
MYELODYSPLASTIC SYNDROME, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Comparison of Intensive Chemotherapy and Hypomethylating Agents before Allogeneic Stem Cell Transplantation for Advanced Myelodysplastic Syndromes: A Study of the Myelodysplastic Syndrome Subcommittee of the Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplant Research.	27264633
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	The European Society for Blood and Marrow Transplant Research data set was used to retrospectively analyze the outcomes of hypomethylating therapy (HMA) compared with those of conventional chemotherapy (CC) before hematopoietic stem cell transplantation (HSCT) in 209 patients with advanced myelodysplastic syndromes.	27264633
Lymphoma	Stem Cell Exhaustion	Effect of the addition of rituximab to salvage chemotherapy prior to autologous stem cell transplant in aggressive CD20+ lymphoma: a cohort comparison from the NCIC Clinical Trials Group Study LY.12^.	27266754
Coronary Arteriosclerosis	Stem Cell Exhaustion	Circulating Progenitor Cells Identify Peripheral Arterial Disease in Patients With Coronary Artery Disease.	27267067
Atherosclerosis	Stem Cell Exhaustion	Decline in the number of bone marrow-derived circulating progenitor cells (PCs) is thought to contribute to the pathogenesis of atherosclerosis.	27267067
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Ocular involvement of chronic graft-versus-host disease (cGVHD) is a complication that occurs in up to 60% of patients after allogeneic hematopoietic stem cell transplantation.	27269196
Rheumatoid Arthritis	Stem Cell Exhaustion	Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis (Cx611): results of a multicentre, dose escalation, randomised, single-blind, placebo-controlled phase Ib/IIa clinical trial.	27269294
Rheumatoid Arthritis	Stem Cell Exhaustion	To evaluate the safety and tolerability of the intravenous administration of Cx611, a preparation of allogeneic expanded adipose-derived stem cells (eASCs), in patients with refractory rheumatoid arthritis (RA), as well as to obtain preliminary clinical efficacy data in this population.	27269294
selenium	Stem Cell Exhaustion	Intensive chemotherapy and stem cell transplantation in MRD-based high-risk patients resulted in a significantly better 5-year EFS rate (78%, SE 8% v 16%, SE 8% in controls).	27269950
Werner Syndrome	Stem Cell Exhaustion	Vitamin C alleviates aging defects in a stem cell model for Werner syndrome.	27271327
ELN wt Allele	Stem Cell Exhaustion	We have recently developed a novel human WS model using WRN-deficient human mesenchymal stem cells (MSCs).	27271327
pulmonary toxicity, Neoplasms	Stem Cell Exhaustion	Aggressive Metastatic Inflammatory Myofibroblastic Tumor After Allogeneic Stem Cell Transplant With Fatal Pulmonary Toxicity From Crizotinib.	27271810
Neoplasm Metastasis	Stem Cell Exhaustion	IMTs are uncommon secondary malignancies after hematopoietic stem cell transplant.	27271810
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	Sex-determining region Y-box binding protein-2 (SOX2) and aldehyde dehydrogenase-1 (ALDH1) are known cancer stem-cell markers, and represent candidate predictors for breast cancer prognosis.	27272809
Childhood Breast Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Backgroung/Aim: Breast cancer resistance protein [BCRP/ATP-binding cassette subfamily G member 2 (ABCG2)] is a member of the ATP-binding cassette transporter family, used as a maker of cancer stem cells (CSCs) and thought to be responsible for drug resistance by pumping them out of cells.	27272814
Somatic mosaicism	Stem Cell Exhaustion	Amplicon-based deep sequencing revealed somatic NLRP3 mosaicism restricted to myeloid cells (31.8% in monocytes, 24.6% in neutrophils, and 11.2% in circulating CD34+ common myeloid progenitor cells) and its complete absence in lymphoid cells.	27273849
Myeloproliferative disease, Primary Myelofibrosis, Fibrosis Assessment, Splenomegaly, PMF Regimen	Stem Cell Exhaustion	Primary myelofibrosis (PMF) is a Philadelphia-negative (Ph-) myeloproliferative disorder, showing abnormal CD34+ progenitor cell trafficking, splenomegaly, marrow fibrosis leading to extensive extramedullary haematopoiesis, and abnormal neoangiogenesis in either the bone marrow or the spleen.	27281335
Lymphoma	Stem Cell Exhaustion	Twenty Years of Autologous Stem Cell Transplantation in Diffuse Large B-Cell Lymphoma: A Single Portuguese Center Experience.	27285096
Adenocarcinoma of lung (disorder)	Stem Cell Exhaustion	Prognostic significance of stem cell-related marker expression and its correlation with histologic subtypes in lung adenocarcinoma.	27285762
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSCs) are a small subset of tumor cells that exhibit stem cell-like properties and contribute in treatment failure.	27285762
Specialty Type - cancer	Stem Cell Exhaustion	Novel cancer stem cell targets during epithelial to mesenchymal transition in PTEN-deficient trastuzumab-resistant breast cancer.	27285982
Childhood Breast Carcinoma	Stem Cell Exhaustion	Continued use of trastuzumab in PTEN-deficient HER2+ breast cancer induces the epithelial-to-mesenchymal transition (EMT), transforms HER2+ to triple negative breast cancer, and expands breast cancer stem cells (BCSCs).	27285982
Prostate	Stem Cell Exhaustion	Prostate tumor-induced angiogenesis is blocked by exosomes derived from menstrual stem cells through the inhibition of reactive oxygen species.	27286448
Neoplasms	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) secrete exosomes that are capable of modifying the tumor environment through different mechanisms including changes in the cancer-cell secretome.	27286448
Neoplasms	Stem Cell Exhaustion	Hence, we studied the angiogenic activity of menstrual stem cells (MenSCs)-secreted exosomes on prostate PC3 tumor cells.	27286448
Neurodevelopmental Disorders	Stem Cell Exhaustion	A Dichotomy of Information-Seeking and Information-Trusting: Stem Cell Interventions and Children with Neurodevelopmental Disorders.	27286955
Atrial Septal Defects	Stem Cell Exhaustion	The potential of stem cell technologies as an interventional strategy for CP and ASD has gained attention in the last decade.	27286955
Atrial Septal Defects	Stem Cell Exhaustion	In this study, we surveyed individuals who considered taking their child with ASD or CP abroad for stem cell interventions on their use of different sources of stem cell related health information and their level of trust in these sources.	27286955
Hematologic Neoplasms, Vancomycin-Resistant Enterococci	Stem Cell Exhaustion	Room contamination, patient colonization pressure, and the risk of vancomycin-resistant Enterococcus colonization on a unit dedicated to the treatment of hematologic malignancies and hematopoietic stem cell transplantation.	27287734
Hematologic Neoplasms	Stem Cell Exhaustion	Whether these apply to modern units dedicated to the care of hematologic malignancies and hematopoietic stem cell transplant (HSCT) procedures is unknown.	27287734
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Safety and efficacy of autologous thymosin b4 pre-treated endothelial progenitor cell transplantation in patients with acute ST segment elevation myocardial infarction: A pilot study.	27288307
Neoplasms	Stem Cell Exhaustion	Stromal cells in phyllodes tumors of the breast are enriched for EZH2 and stem cell marker expression.	27290698
Childhood Breast Carcinoma	Stem Cell Exhaustion	Enhancer of Zeste 2 (EZH2) epigenetically regulates cell-type identity, cellular differentiation, and breast cancer stem cells.	27290698
Neoplasms	Stem Cell Exhaustion	Our study also suggests that PTs contain mesenchymal stem cells, shedding light into the pathogenesis of these tumors.	27290698
Multiple Sclerosis, Chronic Progressive	Stem Cell Exhaustion	Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial.	27291994
MS gene	Stem Cell Exhaustion	Strong immunosuppression, including chemotherapy and immune-depleting antibodies followed by autologous haemopoietic stem-cell transplantation (aHSCT), has been used to treat patients with multiple sclerosis, improving control of relapsing disease.	27291994
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Outcome of allogeneic stem cell transplantation for AML and myelodysplastic syndrome in elderly patients (60 years).	27295269
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic stem cell transplantation (SCT) remains the best curative option for patients with refractory AML or with high-risk myelodysplastic syndrome (MDS).	27295269
Lymphoma, Follicular	Stem Cell Exhaustion	Rituximab maintenance after autologous stem cell transplantation prolongs response duration in non-naive rituximab follicular lymphoma patients: a single institution experience.	27297970
Lymphoma, Follicular	Stem Cell Exhaustion	We retrospectively evaluated the role of rituximab (R) in maintenance treatment after autologous stem cell transplantation performed in patients with relapsed follicular lymphoma.	27297970
Haiti	Stem Cell Exhaustion	Autologous stem cell transplantation improved the outcomes of patients with HT (median overall survival, not reached v 1.7 years) but not of patients with persistent FL histology.	27298402
Haiti	Stem Cell Exhaustion	HT in patients with FL who previously responded to immunochemotherapy is an early event associated with a poor outcome that may deserve intensive salvage with autologous stem cell transplantation.	27298402
Teratoma	Stem Cell Exhaustion	By controlling telomere length of ES cells through telomerase inactivation, we can inhibit teratoma formation and potentially improve the safety of cell therapies involving terminally differentiated cells as well as specific progenitor cells that do not require sustained cellular proliferation in vivo, and thus sustained telomerase activity.	27299710
Osteoporosis	Stem Cell Exhaustion	Histone modification enzyme is chemically modifiable; therefore, PCAF may represent a novel therapeutic target for stem cell-mediated regenerative medicine and the treatment of osteoporosis.	27300495
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	Reduced survival in patients with early-stage non-small-cell lung cancer is associated with high pleural endothelial progenitor cell levels.	27301385
Congestive heart failure, Pleural Effusion, CTCAE, Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	Pleural endothelial progenitor cell levels were quantified by fluorescence-activated cell sorting analysis in pleural effusion of 15 patients with late-stage non-small-cell lung cancer with pleural involvement and in 15 control patients with congestive heart failure.	27301385
Specialty Type - cancer	Stem Cell Exhaustion	Cancer recurrence and survival was evaluated in patients with high pleural-drainage endothelial progenitor cell levels.	27301385
Lung diseases, Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	Also, pleural-drainage endothelial progenitor cell levels were higher in patients with non-small-cell lung cancer than in patients with benign lung disease undergoing pulmonary resection (P < 0.05).	27301385
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	Non-small-cell lung cancer patients with high pleural-drainage endothelial progenitor cell levels had a significantly 4.9 higher rate of cancer recurrence/death than patients with lower pleural-drainage endothelial progenitor cell levels, irrespective of confounders.	27301385
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	Endothelial progenitor cell levels are higher in the post-surgery pleural drainage of patients with non-small-cell lung cancer than in non-neoplastic pleural-drainage fluid.	27301385
Cessation of life, Non-Small Cell Lung Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	High pleural-drainage endothelial progenitor cell levels in patients undergoing pulmonary resection for early non-small-cell lung cancer predict an increased risk of cancer recurrence and death.	27301385
Neoplasms	Stem Cell Exhaustion	Endothelial progenitor cells are capable of contributing to neovascularization in tumours.	27301385
Pleural Effusion, CTCAE	Stem Cell Exhaustion	In patients with either malignant or transudative pleural effusion, we tested the presence of pleural endothelial progenitor cells.	27301385
Lung diseases, Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	We also measured the number of endothelial progenitor cells in post-surgery pleural drainage of either patients with early non-small-cell lung cancer or control patients with benign lung disease undergoing pulmonary resection.	27301385
Specialty Type - cancer	Stem Cell Exhaustion	The prospective influence of post-surgery pleural-drainage endothelial progenitor cells on cancer recurrence/survival was investigated.	27301385
Lung diseases, Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	Also, pleural-drainage endothelial progenitor cells were measured in pleural-drainage fluid 48 h after surgery in 64 patients with early-stage non-small-cell lung cancer and 20 benign lung disease patients undergoing pulmonary resection.	27301385
Pleural Effusion, CTCAE	Stem Cell Exhaustion	The number of pleural endothelial progenitor cells was higher in non-small-cell lung cancer pleural effusion than in transudative pleural effusion.	27301385
Congestive heart failure, Pleural Effusion, CTCAE, Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	Endothelial progenitor cells are present in the pleural effusion and are higher in patients with late-stage non-small-cell lung cancer with pleural involvement than in congestive heart failure patients.	27301385
leukemia, Multiple Myeloma	Stem Cell Exhaustion	On the basis of data showing KIR-ligand mismatched natural killer (NK) cells reduce the risk of leukemia and multiple myeloma relapse following allogeneic hematopoietic stem cell transplantation, investigators have developed a checkpoint inhibition antibody that blocks KIR on NK cells.	27307594
palladium	Stem Cell Exhaustion	In preparation for the clinical study we performed a cell tissue culture study with human embryonic stem cell (hESC)-derived midbrain dopamine (mDA) neurons that were treated with rotenone as a model for PD.	27309537
Autoimmune Diseases	Stem Cell Exhaustion	A Preliminary Online Study on Menstruation Recovery in Women After Autologous Hematopoietic Stem Cell Transplant for Autoimmune Diseases.	27310497
Autoimmune Diseases	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplant has become a successful treatment option in aggressive autoimmune diseases.	27310497
Autoimmune Diseases	Stem Cell Exhaustion	The aim of our study was to analyze information on menstruation recovery after autologous hematopoietic stem cell transplant for autoimmune diseases.	27310497
Autoimmune Diseases	Stem Cell Exhaustion	An anonymous online questionnaire was distributed among members of an international Web forum of patients who had autologous hematopoietic stem cell transplant for autoimmune disease.	27310497
Autoimmune Diseases	Stem Cell Exhaustion	However, a significant number of responders who underwent autologous hematopoietic stem cell transplant for autoimmune diseases already had children before transplant and indicated no desire for pregnancy after transplant; the data on pregnancy occurrence in this group should be interpreted in this context.	27310497
Erythema Infectiosum, Multiple Myeloma	Stem Cell Exhaustion	Chronic persistent parvovirus B19 bone marrow infection resulting in transfusion-dependent pure red cell aplasia in multiple myeloma after allogeneic haematopoietic stem cell transplantation and severe graft versus host disease.	27311084
Graft-vs-Host Disease, Steroid-Refractory Pneumonitis, human parvovirus B19 virus, Communicable Diseases	Stem Cell Exhaustion	We report a chronic persistent Parvovirus B19 (PVB19) infection despite long-term immunoglobulin substitution intravenous immunoglobulin (IVIG) and tapering of immune-suppressive therapy in a 41-year-old patient after allogeneic haematopoietic stem cell transplantation (alloHSCT) and long-term immune-suppressive therapy due to a steroid-refractory graft versus host disease (GvHD).	27311084
Pure Red-Cell Aplasia	Stem Cell Exhaustion	After 30 months, a bone marrow (BM) examination still revealed a highly dysplastic erythropoiesis without any cellular maturation, and a high-grade expression of PVB19 within the dysplastic erythropoietic progenitor cells, consistent with a PRCA due to a PVB19 infection of the BM.	27311084
Infection	Stem Cell Exhaustion	Invasive mold infections (IMIs) are major complications after allogeneic hematopoietic stem cell transplantation (HSCT) with high mortality.	27311967
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Risk factors for a new IMI in multivariate analysis were older age, grades II to IV acute graft-versus-host disease (GVHD) (risk hazard, 4.1; 95% CI, 1.9 to 8.8; P < .001), treatment with mesenchymal stromal cells (risk hazard, 4.0; 95% CI, 2.1 to 7.8; P < .001), transplantation with female donor to male recipient (risk hazard, 2.2; 95% CI, 1.1 to 4.3; P = .02), and hematopoietic stem cell transplantation-specific comorbidity index over 5 (risk hazard, 2.8; 95% CI, 1.1 to 6.8; P = .03).	27311967
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	Addition of high-dose cytarabine to immunochemotherapy before autologous stem-cell transplantation in patients aged 65 years or younger with mantle cell lymphoma (MCL Younger): a randomised, open-label, phase 3 trial of the European Mantle Cell Lymphoma Network.	27313086
Mantle cell lymphoma	Stem Cell Exhaustion	The European Mantle Cell Lymphoma Network aimed to investigate whether the introduction of high-dose cytarabine to immunochemotherapy before autologous stem-cell transplantation (ASCT) improves outcome.	27313086
Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	Notch signaling abnormalities are reported to be involved in the acceleration of malignancy in solid tumors and stem cell formation or regeneration in various organs.	27315779
Malignant neoplasm of liver	Stem Cell Exhaustion	The g-secretase inhibitors suppressed cell growth of the epithelial cell adhesion molecule-positive fraction in hepatoma cells, indicating that Notch inhibitors could suppress the stem cell features of liver cancer cells.	27315779
B-Cell Lymphomas	Stem Cell Exhaustion	The different roles of molecular classification according to upfront autologous stem cell transplantation in advanced-stage diffuse large B cell lymphoma patients with elevated serum lactate dehydrogenase.	27324387
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	To investigate the role of molecular classification according to upfront autologous hematopoietic stem cell transplantation (ASCT), we retrospectively evaluated 219 newly diagnosed high-risk DLBCL patients.	27324387
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Imatinib mesylate and new TKIs along with allogeneic stem cell transplantation and other factors have contributed to the life expectancy in patients with CML approaching that of the general population today.	27325849
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Purpose This analysis of the FIRST trial in patients with newly diagnosed multiple myeloma (MM) ineligible for stem-cell transplantation examined updated outcomes and impact of patient age.	27325857
Dystrophy, "Stargardts disease	Stem Cell Exhaustion	A 60-year-old man with Stargardt's macular dystrophy and visual acuity of 20/400 in the right eye and 20/60 in the left eye underwent a subretinal injection of autologous bone marrow-derived stem cells in the right eye.	27327294
Retinal Detachment	Stem Cell Exhaustion	Retinal detachment may occur after subretinal injection of stem cells.	27327294
Cell Differentiation process, Teratoma	Stem Cell Exhaustion	An advantage of somatic cell differentiation without first generating induced pluripotent stem cells (iPSCs) is that it avoids contamination of the differentiated cells with residual iPSCs, which may cause teratoma.	27328768
Neoplasms	Stem Cell Exhaustion	Biomarker studies included immune subsets, circulating tumor cells (CTCs), circulating endothelial cells (CECs), circulating endothelial progenitor cells (CEPs), and osteopontin.	27328856
Liver carcinoma, Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Prognostic value of the expression of cancer stem cell-related markers CD133 and CD44 in hepatocellular carcinoma: From patients to patient-derived tumor xenograft models.	27329727
Liver carcinoma, Specialty Type - cancer, Hollings Cancer Center	Stem Cell Exhaustion	High expression of cancer stem cell (CSC) markers is related to poor prognosis of patients with hepatocellular carcinoma (HCC).	27329727
Graft-vs-Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Haplo-cord stem cell transplantation combines the infusion of CD34 selected hematopoietic progenitors from a haplo-identical donor with an umbilical cord blood (UCB) graft from an unrelated donor and allows faster count recovery, with low rates of disease recurrence and chronic graft-versus-host disease (GVHD).	27333804
Cataract	Stem Cell Exhaustion	The aging of lens progenitor cell has been repeatedly proposed to play a key role in age-related cataracts (ARCs), but the mechanism is far from being understood.	27336873
Cataract	Stem Cell Exhaustion	Only cortical cataract classification was found to be strongly related to the percentage of SA-b-gal and senescent HLECs.Our study gave the initial evidence on the dynamical change of lens stem/progenitor cells in human lens capsule with age and suggested that lens progenitor/epithelial cell aging is important in the severity of cortical cataracts.	27336873
Osteoporosis, Postmenopausal	Stem Cell Exhaustion	MiR-27a is Essential for the Shift from Osteogenic Differentiation to Adipogenic Differentiation of Mesenchymal Stem Cells in Postmenopausal Osteoporosis.	27337099
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	Stem Cell Exhaustion	Endothelial progenitor cells are differentially impaired in ANCA-associated vasculitis compared to healthy controls.	27338585
Crohn Disease	Stem Cell Exhaustion	Circulating Bone Marrow-Derived CD45-/CD34+/CD133+/VEGF+ Endothelial Progenitor Cells in Adults with Crohn's Disease.	27339637
Osteosarcoma	Stem Cell Exhaustion	Mesenchymal stem cells promote osteosarcoma cell survival and drug resistance through activation of STAT3.	27340780
Osteosarcoma, Neoplasms	Stem Cell Exhaustion	In this study, we tried to determine whether the mesenchymal stem cells (MSCs) in the tumor microenvironment contribute to the increased chemoresistance of osteosarcoma.	27340780
Specialty Type - cancer	Stem Cell Exhaustion	Identifying the CETC subset with cancer stem cell properties may provide more clinically useful prognostic information.	27340862
Specialty Type - cancer	Stem Cell Exhaustion	This population is termed cancer stem cells (CSCs).	27340862
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	We have developed a simple method for identification and characterization of circulating cancer stem cells among circulating epithelial tumor cells (CETCs).	27340862
Specialty Type - cancer	Stem Cell Exhaustion	Analysis of surface marker expression profile of tumorspheres showed that cells in the spheres had typical phenotype of cancer stem cells.	27340862
Neoplasms	Stem Cell Exhaustion	Epstein-Barr virus-associated smooth muscle tumor of the cavernous sinus: a delayed complication of allogenic peripheral blood stem cell transplantation: case report.	27341041
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	She had a prior history of acute myelogenous leukemia requiring allogenic peripheral blood stem cell transplantation 2 years earlier, but she was in a remission phase.	27341041
Specialty Type - cancer, Malignant neoplasm of liver	Stem Cell Exhaustion	The network of stemness genes and oncogenes in human patient-specific reprogrammed cancer stem cells (CSCs) remains elusive, especially in liver cancer.	27341307
Amyloidosis	Stem Cell Exhaustion	Induction therapy pre-autologous stem cell transplantation in immunoglobulin light chain amyloidosis: a retrospective evaluation.	27341539
Amyloidosis	Stem Cell Exhaustion	There is no consensus on whether patients with immunoglobulin light chain amyloidosis (AL) should receive induction therapy prior to an autologous stem cell transplant (ASCT).	27341539
Mycoses	Stem Cell Exhaustion	Baseline cytokine profiling identifies novel risk factors for invasive fungal disease among haematology patients undergoing intensive chemotherapy or haematopoietic stem cell transplantation.	27343564
Lymphoma	Stem Cell Exhaustion	Daily Weight-Based Busulfan with Cyclophosphamide and Etoposide Produces Comparable Outcomes to Four-Times-Daily Busulfan Dosing for Lymphoma Patients Undergoing Autologous Stem Cell Transplantation.	27343718
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	To facilitate a therapeutic dose-monitoring protocol, we transitioned from Bu6 to daily Bu dosing for patients with Hodgkin and non-Hodgkin lymphoma undergoing autologous stem cell transplantation (ASCT).	27343718
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Hematopoietic Progenitor Cell Mobilization with Ifosfamide, Carboplatin, and Etoposide Chemotherapy versus Plerixafor-Based Strategies in Patients with Hodgkin and Non-Hodgkin Lymphoma.	27345140
Lymphoma	Stem Cell Exhaustion	We analyzed hematopoietic progenitor cell mobilization outcomes in lymphoma patients undergoing chemo-mobilization with ICE (n = 35) compared with either routine plerixafor (n = 30) or "just in time" (JIT) plerixafor-based mobilization (n = 33).	27345140
Pick Disease of the Brain	Stem Cell Exhaustion	Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a P301L mutation in microtubule-associated protein tau (MAPT).	27345788
LIN28A wt Allele	Stem Cell Exhaustion	Induced pluripotent stem cells (iPSCs) were established by electroporation with episomal plasmids containing hOCT4, hSOX2, hKLF2, hL-MYC, hLIN-28 and shP53.	27345788
LIN28A wt Allele	Stem Cell Exhaustion	Induced pluripotent stem cell (iPSCs) were established by electroporation with episomal plasmids containing hOCT4, hSOX2, hKLF2, hL-MYC, hLIN-28 and shP53.	27345791
Pick Disease of the Brain	Stem Cell Exhaustion	Induced pluripotent stem cells (iPSCs) derived from a pre-symptomatic carrier of a R406W mutation in microtubule-associated protein tau (MAPT) causing frontotemporal dementia.	27345791
EN1 wt Allele, "Alzheimers Disease	Stem Cell Exhaustion	Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying a L150P mutation in PSEN-1.	27345792
Up, "Alzheimers Disease	Stem Cell Exhaustion	Induced pluripotent stem cells (iPSCs) were generated from skin fibroblasts isolated from a 58-year old male with a L150P mutation in the presenilin 1 (PSEN-1) gene, which is responsible for the majority of familial cases of Alzheimer's disease (AD).	27345792
Alzheimers Disease	Stem Cell Exhaustion	Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying an A79V mutation in PSEN1.	27345973
Alzheimers Disease	Stem Cell Exhaustion	Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying a M146I mutation in PSEN1.	27345998
Cerebral Hemorrhage	Stem Cell Exhaustion	Increased Endothelial Progenitor Cell Levels are Associated with Good Outcome in Intracerebral Hemorrhage.	27346699
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Within the transplant-eligible population, 52% of patients with DLBCL and 96% of patients with HL proceeded to stem cell transplantation.	27347845
Aplastic Anemia	Stem Cell Exhaustion	Comparable outcomes between younger (40 years) and older (>40 years) adult patients with severe aplastic anemia after HLA-matched sibling stem cell transplantation using fludarabine-based conditioning.	27348538
Aplastic Anemia	Stem Cell Exhaustion	Allogeneic stem cell transplantation from HLA-matched siblings (MSD-SCT) for elderly patients with severe aplastic anemia (SAA) is not a widely accepted first-line treatment.	27348538
Hematologic Neoplasms	Stem Cell Exhaustion	Younger children are considered to be more vulnerable to late effects (LE), which prompted us to study LE in patients after haematopoietic stem cell transplantation (HSCT) for a haematological malignancy before the age of 3.	27348540
Choroid Diseases	Stem Cell Exhaustion	Cellular senescence as a result of organismal aging or progeroid diseases leads to stem cell pool exhaustion hindering tissue regeneration and contributing to the progression of age related disorders.	27350449
Lymphoma	Stem Cell Exhaustion	We compared VO2peak among lymphoma survivors (LSs) with reference data from healthy sedentary subjects, after a 10.2-year (mean) follow-up post high-dose chemotherapy with autologous stem cell transplantation (HDT-ASCT).	27351215
Colorectal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	A Study on the Mechanism of Low-Expressed Cancer Stem Cell Marker Lgr5 in Inhibition of the Proliferation and Invasion of Colorectal Carcinoma.	27352328
Colorectal Carcinoma, Neoplasms, Cytogenetic Complete Response	Stem Cell Exhaustion	The present study intends to explore the influence of Lgr5 as a marker of tumor stem cells after siRNA interference on the proliferation and invasion of colorectal carcinoma (CRC) and its mechanism.	27352328
Leukemia, Myelomonocytic, Chronic	Stem Cell Exhaustion	The frequencies of TET2/DNMT3A and SRSF2 variants could support the hypothesis that TET2/DNMT3A mutations occurred in an early progenitor cell, which later progressed to both the AITL and CMML clones.	27353473
Malignant neoplasm of ovary, Specialty Type - cancer, Resistance Process	Stem Cell Exhaustion	Cancer Stem Cell Properties as Factors Predictive of Chemoresistance in Neoadjuvantly-treated Patients with Ovarian Cancer.	27354603
Malignant neoplasm of ovary	Stem Cell Exhaustion	The nuclear factor erytheroid 2-related factor 2-kelch-like ECH-associated protein (NRF2-KEAP1) system and stem cell-like cancer cells are associated with platinum resistance in ovarian cancer.	27354603
Malignant neoplasm of ovary	Stem Cell Exhaustion	Our objective was to investigate the possible association between platinum resistance, cellular redox-state regulation and stem cell properties in ovarian cancer.	27354603
Multiple Myeloma	Stem Cell Exhaustion	We identified 641 patients with multiple myeloma who had been treated using novel agents and/or autologous stem cell transplantation with high-dose chemotherapy between January 2006 and June 2014 at nine Japanese hospitals.	27358178
Small cell carcinoma of lung, Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Cancer Stem Cells, Epithelial to Mesenchymal Markers, and Circulating Tumor Cells in Small Cell Lung Cancer.	27363902
Neoplasms, Small cell carcinoma of lung, Specialty Type - cancer	Stem Cell Exhaustion	Elevated levels of circulating tumor cells (CTCs) have been associated with a worse prognosis, and markers of cancer stem cells (CSCs) and epithelial to mesenchymal transition have been associated with increased chemoresistance and metastatic spread in SCLC.	27363902
Lymphoma	Stem Cell Exhaustion	Retrospective evaluation of the MEAM regimen as a conditioning regimen before autologous peripheral blood stem cell transplantation for lymphoma in two centers with different dosing schedules of melphalan.	27365141
Lymphoma	Stem Cell Exhaustion	The BEAM regimen consisting of carmustine (BCNU), etoposide, cytarabine, and melphalan (MEL) is widely used before autologous hematopoietic stem cell transplantation (auto-HSCT) for lymphoma.	27365141
Hypertensive (finding), Chronic Kidney Disease, CTCAE	Stem Cell Exhaustion	Our aim was to characterize the endothelial progenitor cells (EPCs) in normotensive controls and treated hypertensive individuals within the vascular endothelial growth factor (VEGF) -460 C/T polymorphism as well as to investigate whether this polymorphism predisposes to hypertension-related chronic kidney disease.	27367286
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	Differences in expression of the cancer stem cell marker aldehyde dehydrogenase 1 among estrogen receptor-positive/human epidermal growth factor receptor type 2-negative breast cancer cases with early, late, and no recurrence.	27368476
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	The significance of the expression of aldehyde dehydrogenase 1 (ALDH1), a cancer stem cell marker, for predicting the recurrence of estrogen receptor (ER)-positive/human epidermal growth factor receptor type 2 (HER2)-negative breast cancer is still poorly understood.	27368476
Specialty Type - cancer	Stem Cell Exhaustion	Further study is needed to clarify the prognostic significance of the heterogeneity of cancer stem cells and to confirm their role in resistance to chemotherapy.	27368476
Functional Laterality	Stem Cell Exhaustion	Human neural progenitor cell applied treatment modalities may be an effective strategy to help maintain retinal functionality in neurodegenerative pathologies.	27369448
Photoreceptor degeneration	Stem Cell Exhaustion	Human neural progenitor cells decrease photoreceptor degeneration, normalize opsin distribution and support synapse structure in cultured porcine retina.	27369448
KMT2A gene, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The Superiority of Allogeneic Hematopoietic Stem Cell Transplantation Over Chemotherapy Alone in the Treatment of Acute Myeloid Leukemia Patients with Mixed Lineage Leukemia (MLL) Rearrangements.	27373985
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Infusion of a non-HLA-matched ex-vivo expanded cord blood progenitor cell product after intensive acute myeloid leukaemia chemotherapy: a phase 1 trial.	27374466
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Infusion of the expanded progenitor cell product seemed safe and might provide a promising treatment method for patients with acute myeloid leukaemia.	27374466
Infection	Stem Cell Exhaustion	We investigated the use of non-HLA-matched ex-vivo expanded cord blood progenitor cells to accelerate haemopoietic recovery and reduce infections after chemotherapy.	27374466
Toxic effect, Hypersensitivity	Stem Cell Exhaustion	We observed one case of acute infusional toxicity (attributed to an allergic reaction to dimethyl sulfoxide) in the 29 patients enrolled, who received 42 infusions of expanded progenitor cells.	27374466
Multiple Myeloma	Stem Cell Exhaustion	The effect of salvage autologous stem-cell transplantation on overall survival in patients with relapsed multiple myeloma (final results from BSBMT/UKMF Myeloma X Relapse [Intensive]): a randomised, open-label, phase 3 trial.	27374467
Multiple Myeloma	Stem Cell Exhaustion	The Myeloma X trial previously reported improved durability of response (time to disease progression) in patients with relapsed multiple myeloma with salvage autologous stem-cell transplantation (ASCT) compared with oral cyclophosphamide in patients with multiple myeloma relapsing after a first ASCT.	27374467
Hematologic Neoplasms	Stem Cell Exhaustion	Allogeneic Hematopoietic Stem Cell Transplantation after Conditioning Regimens with Fludarabine/melphalan or Fludarabine/busulfan for Patients with Hematological Malignancies: A Single-center Analysis.	27374671
Fetal Measurements Domain	Stem Cell Exhaustion	Objective Fludarabine plus melphalan (FM) and fludarabine plus busulfan (FB) are two major conditioning regimens for allogeneic hematopoietic stem cell transplantation (allo-HSCT).	27374671
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplant for multiple myeloma patients 70 years or older.	27376447
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplant (Auto-SCT) is increasingly used in older patients with multiple myeloma (MM), despite lack of phase 3 trials in this age-defined population.	27376447
Lymphoma	Stem Cell Exhaustion	Risk factors predicting outcomes for primary refractory hodgkin lymphoma patients treated with salvage chemotherapy and autologous stem cell transplantation.	27377168
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	We aimed to identify risk factors that predict functional imaging (FI) response to salvage chemotherapy and evaluate outcomes following autologous stem cell transplant (ASCT) in primary refractory Hodgkin Lymphoma (HL).	27377168
Toxic nephropathy	Stem Cell Exhaustion	Their lack of renal toxicity makes them attractive regimens, which may be interesting for patients eligible for autologous stem cell transplantation.	27377614
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	In recent decades, the prognosis of Mantle Cell Lymphoma (MCL) has been significantly improved by intensified first-line regimens containing cytarabine, rituximab and consolidation with high-dose-therapy and autologous stem cell transplantation.	27378674
Symptoms	Stem Cell Exhaustion	A retrospective chart review of 35 patients with a history of ocular GVHD following hematopoietic stem cell transplantation that used ASED to alleviate dry eye symptoms was performed.	27380960
Hematological Disease	Stem Cell Exhaustion	It is important for maintenance of stem cell homeostasis and its aberrant activation has been implicated in a wide array of malignant hematological disorders.	27381374
Corneal Scar, Corneal graft failure, Impaired T cell function	Stem Cell Exhaustion	The most common indication for surgery was corneal graft failure (n=23; 52.3%) followed by corneal scar (n=8; 18.2%) and limbal stem cell dysfunction (n=8; 18.2%).	27381593
Hodgkin Disease, Relapsing course	Stem Cell Exhaustion	Bendamustine in Combination With Gemcitabine and Vinorelbine Is an Effective Regimen As Induction Chemotherapy Before Autologous Stem-Cell Transplantation for Relapsed or Refractory Hodgkin Lymphoma: Final Results of a Multicenter Phase II Study.	27382096
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	This multicenter, open-label, phase II study evaluated the combination of bendamustine, gemcitabine, and vinorelbine (BeGEV) as induction therapy before autologous stem-cell transplantation (ASCT) in patients with relapsed or refractory Hodgkin lymphoma (HL).	27382096
Toxic effect	Stem Cell Exhaustion	Secondary end points were: overall response rate, stem-cell mobilization activity, and toxicity.	27382096
Hypertensive (finding)	Stem Cell Exhaustion	In addition, higher number of immature endothelial progenitor cells with CD34(+)CD133(+), CD34(+)CD133(-) markers was observed in GG hypertensive carriers while in normotensive individuals no differences were found.	27382979
Multiple Myeloma	Stem Cell Exhaustion	We evaluated 1070 patients with newly diagnosed multiple myeloma, who completed a single line of induction therapy followed by autologous stem cell transplantation.	27390076
Myeloid, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Mesenchymal Stem Cells (MSC) Regulate Activation of Granulocyte-Like Myeloid Derived Suppressor Cells (G-MDSC) in Chronic Myeloid Leukemia Patients.	27391078
Neoplasms, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	It is well known that mesenchymal stem cells (MSC) have a role in promotion of tumor growth, survival and drug-resistance in chronic myeloid leukemia (CML).	27391078
Malignant Head and Neck Neoplasm, leukemia	Stem Cell Exhaustion	Notch pathway plays a complex role depending on cellular contexts: promotes stem cell maintenance or induces terminal differentiation in potential cancer-initiating cells; acts as an oncogene in lymphocytes and mammary tissue or plays a growth-suppressive role in leukemia, liver, skin, and head and neck cancer.	27391340
Neurodegenerative Disorders	Stem Cell Exhaustion	Taken together, our data suggest that neonate NOG mice could be a sensitive animal platform to test tumorigenic potential of stem cell therapeutics and that ahMNCs could be a genetically stable stem cell source with little tumorigenic activity to develop regenerative treatments for neurodegenerative diseases.	27391353
Neurodegenerative Disorders	Stem Cell Exhaustion	Stem cells and therapeutic genes are emerging as a new therapeutic approach to treat various neurodegenerative diseases with few effective treatment options.	27391353
Neoplasms	Stem Cell Exhaustion	However, potential formation of tumors by stem cells has hampered their clinical application.	27391353
Multiple Myeloma, Osteomyelitis	Stem Cell Exhaustion	We present a case of fungal osteomyelitis caused by Lasiodiplodia species in a patient with multiple myeloma after autologous stem cell transplant.	27391908
Specialty Type - cancer	Stem Cell Exhaustion	We evaluated the relationships between PD-L1 positivity, several clinical factors and the immunohistochemical expression of epithelial-mesenchymal transition (EMT), cancer stem cell and proliferative markers.	27393509
Stem Cell Factor, Tumor necrosis	Stem Cell Exhaustion	We compare serum interleukin (IL)-3, IL-6, IL-11, thrombopoietin (Tpo), stem cell factor (SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF), tumour necrosis factor-a (TNFa), and spleen size between these two groups.	27396368
Inflammation	Stem Cell Exhaustion	Intradialytic aerobic cycling exercise alleviates inflammation and improves endothelial progenitor cell count and bone density in hemodialysis patients.	27399127
Metachromatic leukodystrophy, juvenile type	Stem Cell Exhaustion	Long-term Outcome of Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Juvenile Metachromatic Leukodystrophy Compared With Nontransplanted Control Patients.	27400410
ARSA wt Allele, Metachromatic leukodystrophy, juvenile type	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HSCT) has been the only treatment option clinically available during the last 20 years for juvenile metachromatic leukodystrophy (MLD), reported with variable outcome and without comparison with the natural course of the disease.	27400410
Graft-vs-Host Disease	Stem Cell Exhaustion	Selective depletion (SD) of alloreactive T cells from allogeneic hematopoeitic stem cell transplants to prevent graft-versus-host disease (GVHD) without compromising immune reconstitution and antitumor responses remains a challenge.	27401140
Cardiovascular Diseases	Stem Cell Exhaustion	Cilostazol Enhances Mobilization of Circulating Endothelial Progenitor Cells and Improves Endothelium-Dependent Function in Patients at High Risk of Cardiovascular Disease.	27401788
Cardiovascular Diseases, Cyclophosphamide/Vincristine/Dacarbazine Regimen	Stem Cell Exhaustion	This is the first study to investigate the vasculoangiogenic effects of cilostazol on endothelial progenitor cells (EPCs) and flow-mediated dilatation (FMD) in patients at high risk of cardiovascular disease (CVD).	27401788
Alexander Disease	Stem Cell Exhaustion	We established induced pluripotent stem cells from Alexander disease patients, and differentiated induced pluripotent stem cells into astrocytes.	27402089
Alexander Disease	Stem Cell Exhaustion	Astrocytes, differentiated from induced pluripotent stem cells of Alexander disease, could be a cellular model for future translational medicine.	27402089
BONE MARROW FAILURE SYNDROME 1, Aplastic Anemia	Stem Cell Exhaustion	Aplastic anaemia (AA) is a rare acquired bone marrow failure syndrome resulting from the immune-mediated destruction of haemopoietic stem cells.	27404498
Graft-vs-Host Disease	Stem Cell Exhaustion	Results of a 2-arm, phase 2 clinical trial using post-transplantation cyclophosphamide for the prevention of graft-versus-host disease in haploidentical donor and mismatched unrelated donor hematopoietic stem cell transplantation.	27404668
Graft-vs-Host Disease	Stem Cell Exhaustion	High-dose, post-transplantation cyclophosphamide (PTCy) to prevent graft-versus-host disease (GVHD) has improved outcomes in haploidentical (HAPLO) stem cell transplantation (SCT).	27404668
Mucopolysaccharidoses, Mucopolysaccharidosis I	Stem Cell Exhaustion	Hematopoietic stem cell transplants, alongside enzyme replacement therapy and good multi-disciplinary care, have dramatically improved the life expectancy in children with Mucopolysaccharidosis (MPS) I, with better objective and functional outcomes.	27406185
Hematologic Neoplasms	Stem Cell Exhaustion	Loss of donor-mediated immune antitumor activity after allogeneic hematopoietic stem-cell transplantation (HSCT) permits relapse of hematologic cancers.	27410923
Colorectal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer.	27411517
Specialty Type - cancer	Stem Cell Exhaustion	Using our in vitro model, we found that SOX2 expressing cells displayed several characteristics of cancer stem cells; such as a decreased proliferative rate, a spheroid growth pattern, and increased expression of stem cell markers CD24 and CD44.	27411517
Chronic heart failure	Stem Cell Exhaustion	Prognostic relevance of circulating endothelial progenitor cells in patients with chronic heart failure.	27412580
Endothelium	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) are an important endogenous repair mechanism with the ability to counteract endothelial injury and the possibility of new vessel formation.	27412580
Hypertensive (finding)	Stem Cell Exhaustion	Taurine and magnesium supplementation enhances the function of endothelial progenitor cells through antioxidation in healthy men and spontaneously hypertensive rats.	27412799
Cardiovascular Diseases	Stem Cell Exhaustion	Endothelial damage is repaired by endothelial progenitor cells (EPCs), which are pivotal in preventing cardiovascular diseases and prolonging lifespan.	27412799
Specialty Type - cancer, Adenocarcinoma of pancreas	Stem Cell Exhaustion	Co-Expression of Cancer Stem Cell Markers Corresponds to a Pro-Tumorigenic Expression Profile in Pancreatic Adenocarcinoma.	27414409
Specialty Type - cancer	Stem Cell Exhaustion	Its dismal prognosis is often attributed to the presence of cancer stem cells (CSCs) that have been identified in PDAC using various markers.	27414409
Best Case Imputation Technique, Therapy-related myelodysplastic syndrome	Stem Cell Exhaustion	We found elevated t-MDS risk especially among younger BC patients with stem cell transplantation the only observed curative treatment.	27414978
Dyslipidemias	Stem Cell Exhaustion	We studied the effect of rosuvastatin monotherapy or its combination with omega-3 polyunsaturated fatty acids (o-3 PUFAs) on progenitor cell number and function in patients with mixed dyslipidaemia.	27415612
Dyslipidemias	Stem Cell Exhaustion	Effect of rosuvastatin or its combination with omega-3 fatty acids on circulating CD34(+) progenitor cells and on endothelial colony formation in patients with mixed dyslipidaemia.	27415612
Hypercholesterolemia	Stem Cell Exhaustion	Hypercholesterolaemia is associated with a reduced number of circulating progenitor cells, a defect that is restored by statin therapy.	27415612
Bacteremia, Specialty Type - cancer	Stem Cell Exhaustion	All episodes of bacteraemia occurring in hospitalized patients with cancer, including haematopoietic stem cell transplant recipients, from January 2006 to April 2015 were included.	27417156
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is a clonal stem cell disorder frequently associated with inefficient granulopoiesis showing dysplastic polymorphonuclear neutrophils (PMNs).	27417453
Gastrointestinal mucositis	Stem Cell Exhaustion	These findings suggest that polaprezinc lozenge is simple to apply and highly effective for prevention of oral mucositis associated with high-dose chemotherapy for hematopoietic stem cell transplantation.	27418192
Polycystic Kidney, Autosomal Dominant	Stem Cell Exhaustion	We here generated induced pluripotent stem cells (iPSCs) from seven ADPKD patients, including four with ICAs.	27418197
Restenosis, Thrombosis	Stem Cell Exhaustion	With additional endothelial progenitor cell-capturing technology, the Combo stent exhibits a unique late neointimal regression (from 9 to 24 months) that has not been reported in any drug-eluting stents, translating into good 36-month clinical results with minimal restenosis and no late stent thrombosis.	27418609
Multiple Myeloma	Stem Cell Exhaustion	Outcomes in patients with multiple myeloma with TP53 deletion after autologous hematopoietic stem cell transplant.	27420405
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Evolution of acute myelogenous leukemia stem cell properties after treatment and progression.	27421961
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We prospectively characterized leukemia stem cell populations (LSCs) from a well-defined cohort of patients with acute myelogenous leukemia (AML) at diagnosis and relapse to assess the effect of the disease course on these critical populations.	27421961
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells have been postulated to represent a therapy-refractory reservoir for relapse, but formal proof of this model is lacking.	27421961
Thrombocytosis, Polycythemia Vera, Primary Myelofibrosis	Stem Cell Exhaustion	To get further insight in the dynamics of the mutant clone, we assessed the mutant allele burden in hematopoietic stem cells (HSCs), hematopoietic progenitor cells (HPCs) and granulocytes from 138 patients [51 polycythemia vera (PV), 58 essential thrombocythemia (ET) and 29 myelofibrosis (MF)].	27427771
JAK2 NP_004963.1:p.V617F, Myeloproliferative disease	Stem Cell Exhaustion	Characterization of CD34+ hematopoietic progenitor cells in JAK2V617F and CALR-mutated myeloproliferative neoplasms.	27427771
Failure	Stem Cell Exhaustion	A multicenter trial of myeloablative clofarabine and busulfan conditioning for relapsed or primary induction failure AML not in remission at the time of allogeneic hematopoietic stem cell transplantation.	27427921
Amyotrophic Lateral Sclerosis, Antilymphocyte Serum	Stem Cell Exhaustion	Modeling amyotrophic lateral sclerosis (ALS) with human induced pluripotent stem cells (iPSCs) aims to reenact embryogenesis, maturation and aging of spinal motor neurons (spMNs) in vitro.	27428653
Adenovirus Infections	Stem Cell Exhaustion	Occurrence, risk factors and outcome of adenovirus infection in adult recipients of allogeneic hematopoietic stem cell transplantation.	27428881
Adenovirus Infections, Hematological Disease	Stem Cell Exhaustion	We retrospectively analyzed occurrence and risk factors of ADV infection in 399 adults with hematological disorders undergoing hematopoietic stem cell transplantation (allo-HSCT), focusing on alternative donor transplantation (ADT) and disseminated disease.	27428881
MS gene	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation in combination with immunoablative protocol in secondary progressive multiple sclerosis--A 10-year follow-up of the first transplanted patient.	27430119
Infection	Stem Cell Exhaustion	An increase in respiratory syncytial virus type B (RSV-B) infections was detected on an adult hematology/oncology and stem cell transplant unit during March 2015.	27430734
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	The role of ELAM-1 gene in mediating the adhesion of tumor cells to endothelial cells by binding to ELAM-1 ligands expressed by eosinophils, neutrophils, monocytes, natural killer cell effectors, T lymphocyte cells, and cancer (progenitor/stem) cells is well studied.	27433816
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Cord blood (CB) offers a number of advantages over other sources of hematopoietic stem cells, including a lower rate of chronic graft-versus-host disease (cGVHD) in the presence of increased HLA disparity.	27439912
B-Cell Lymphomas	Stem Cell Exhaustion	Clinical impact of early recovery of peripheral blood absolute lymphocyte count after frontline autologous stem cell transplantation for diffuse large B-cell lymphoma.	27440113
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	We conducted a retrospective study to evaluate the clinical impact of an early recovery of posttransplant absolute lymphocyte count (ALC) on the outcome of frontline autologous stem cell transplantation (ASCT) for diffuse large B-cell lymphoma (DLBCL).	27440113
Cerebral Infarction	Stem Cell Exhaustion	In an animal model of transient cerebral ischemia, application of oligodendrocyte progenitor cells (OPCs) has not yet been reported.	27442084
Social security number, Neoplasms	Stem Cell Exhaustion	To describe the utility of simple limbal epithelial transplantation (SLET) along with tumor excision in the management of extensive ocular surface squamous neoplasia (OSSN) to avoid limbal stem cell deficiency (LSCD).	27442321
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	Post-transplant lymphoproliferative disorder arose after hematopoietic stem cell transplant in five and solid organ transplant in 27 patients, a median of 4 and 96 months after transplant, respectively (overall median latency 71 months, range 2-295).	27443517
Cardiotoxicity	Stem Cell Exhaustion	The human amniotic fluid stem cell secretome effectively counteracts doxorubicin-induced cardiotoxicity.	27444332
Cardiotoxicity	Stem Cell Exhaustion	These results support the concept that hAFS are a valuable source of cardioprotective factors and lay the foundations for the development of a stem cell-based paracrine treatment of chemotherapy-related cardiotoxicity.	27444332
Coronary Arteriosclerosis	Stem Cell Exhaustion	The secretome of human amniotic fluid-derived stem cells (hAFS) has previously been demonstrated to significantly reduce ischemic cardiac damage.	27444332
Malignant Peripheral Nerve Sheath Tumor, Myeloproliferative disease	Stem Cell Exhaustion	Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by the proliferation of one or more myeloid lineages.	27444979
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Dysregulation of Vascular Endothelial Progenitor Cells Lung-Homing in Subjects with COPD.	27445517
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	We investigated the hypothesis that lower circulating numbers of vascular endothelial progenitor cells (VEPCs) are a consequence of increased lung-sequestration in COPD.	27445517
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Increased migrational responsiveness of progenitor cells may promote lung-homing of VEPC in COPD which may disrupt maintenance and repair of the airways and contribute to COPD disease pathogenesis.	27445517
Toxic effect, Fanconi Anemia	Stem Cell Exhaustion	Hematopoietic Stem Cell Transplant in Adolescent and Young Adults With Fanconi Anemia Is Feasible With Acceptable Toxicity, With Those Surviving 100 Days Posttransplant Having Excellent Outcomes.	27447289
Bone marrow hypocellularity, Fanconi Anemia	Stem Cell Exhaustion	Hematopoietic stem cell transplant is a potentially curative modality for bone marrow failure in Fanconi anemia patients.	27447289
Fanconi Anemia	Stem Cell Exhaustion	Here, we report our center's experience regarding adolescent and young adult patients with Fanconi anemia and hematopoietic stem cell transplant.	27447289
Fanconi Anemia	Stem Cell Exhaustion	We included patients greater than 14 years old with confirmed Fanconi anemia based on positive chromosome breakage study and who underwent hematopoietic stem cell transplant at our institution.	27447289
Fanconi Anemia	Stem Cell Exhaustion	Our study group comprised 12 patients with Fanconi anemia who underwent hematopoietic stem cell transplant at our institution.	27447289
Acute GVH disease, Pregnancy Complications, Infectious	Stem Cell Exhaustion	Three patients (25%) died early before day 100 after hematopoietic stem cell transplant due to infectious complications, with 1 patient having steroid refractory acute graft-versus-host disease.	27447289
Fanconi Anemia	Stem Cell Exhaustion	Our findings support the feasibility of reduced intensity conditioning allogeneic hematopoietic stem cell transplant in older and more heavily pretreated patients with Fanconi anemia, especially for those who are engrafted.	27447289
Malignant neoplasm of liver	Stem Cell Exhaustion	Overexpression of FGF19/FGFR4 significantly correlated with EpCAM as a marker of hepatic cancer stem cells within the fatty liver-steatosis-cirrhosis-HCC sequence.	27447573
Coronary Arteriosclerosis, Vascular System Injuries, Corneal Endothelial Cell Loss	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPCs), which have the ability to differentiate into mature endothelial cells, can elicit angiogenesis, vasculogenesis and vessel repair in cardiac ischemia and vascular injuries caused by endothelial damage.	27447811
Prostate carcinoma, Secondary Neoplasm	Stem Cell Exhaustion	Aromatic Hydrocarbon Receptor Suppresses Prostate Cancer Bone Metastasis Cells-Induced Vasculogenesis of Endothelial Progenitor Cells under Hypoxia.	27448695
Secondary malignant neoplasm of prostate	Stem Cell Exhaustion	The purpose of this study was to explore whether AHR can suppress hypoxia-induced VEGF production in prostate bone metastasis cells and repress neovascularization in endothelial progenitor cells (EPCs), and, if so, through what mechanisms.	27448695
Malignant tumor of colon	Stem Cell Exhaustion	Pregnane X-receptor promotes stem cell-mediated colon cancer relapse.	27448961
Colorectal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Colorectal cancer lethality usually results from post-treatment relapse in the majority of stage II-IV patients, due to the enhanced resistance of Cancer Stem Cells (CSCs).	27448961
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	There is increasing evidence supporting the cancer stem cell (CSC) hypothesis, which suggests that a population of tumor cells with stem cell characteristics is responsible for tumor growth, resistance, and recurrence as well as drug resistance.	27449042
Glioblastoma	Stem Cell Exhaustion	Immunohistochemical expression of stem cell markers CD44 and nestin in glioblastomas: Evaluation of their prognostic significance.	27450656
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	The response to therapy is variable and may be affected by the presence, within the tumor, of a proportion of cancer stem cells, implicated in chemo- and radioresistance.	27450656
Hodgkin Disease, Failure	Stem Cell Exhaustion	Nivolumab for classical Hodgkin's lymphoma after failure of both autologous stem-cell transplantation and brentuximab vedotin: a multicentre, multicohort, single-arm phase 2 trial.	27451390
Hodgkin Disease, Failure	Stem Cell Exhaustion	We aimed to assess the clinical benefit and safety of nivolumab monotherapy in patients with classical Hodgkin's lymphoma after failure of both autologous stem-cell transplantation and brentuximab vedotin.	27451390
Hodgkin Disease	Stem Cell Exhaustion	In this ongoing, single-arm phase 2 study, adult patients (aged >=18 years) with recurrent classical Hodgkin's lymphoma who had failed to respond to autologous stem-cell transplantation and had either relapsed after or failed to respond to brentuximab vedotin, and with an Eastern Cooperative Oncology Group performance status score of 0 or 1, were enrolled from 34 hospitals and academic centres across Europe and North America.	27451390
Hodgkin Disease	Stem Cell Exhaustion	Nivolumab resulted in frequent responses with an acceptable safety profile in patients with classical Hodgkin's lymphoma who progressed after autologous stem-cell transplantation and brentuximab vedotin.	27451390
Bone necrosis	Stem Cell Exhaustion	A 21-year-old man, allogeneic hematopoietic stem cell transplantation recipient, was referred to our nuclear medicine department for a suspicion of knee osteonecrosis.	27454596
Heart failure, Ischemic cardiomyopathy, Coronary Arteriosclerosis, Myocardial Ischemia	Stem Cell Exhaustion	To determine whether the presence of ischemic heart disease (IHD) per se, or rather the co-presence of heart failure (HF), is the primum movens for less effective stem cell products in autologous stem cell therapy, we assessed numbers and function of bone marrow (BM)-derived progenitor cells in patients with coronary artery disease (n = 17), HF due to ischemic cardiomyopathy (n = 8), non-ischemic HF (n = 7), and control subjects (n = 11).	27456951
Cardiomyopathies, Myocardial Ischemia	Stem Cell Exhaustion	Hence, IHD, with or without associated cardiomyopathy, is an important determinant of progenitor cell function.	27456951
Heart Diseases	Stem Cell Exhaustion	Bone Marrow-Derived Progenitor Cells Are Functionally Impaired in Ischemic Heart Disease.	27456951
Myocardial Ischemia	Stem Cell Exhaustion	No depletion of hematopoietic and endothelial progenitor cells (EPC) within the BM was observed, while circulating EPC numbers were increased in the presence of IHD, suggesting active recruitment.	27456951
Neoplasms	Stem Cell Exhaustion	Xenograft PDAC tumor models were established in mice by inoculation of CD133+ stem cells isolated from PDAC tumors.	27458977
Malignant neoplasm of stomach	Stem Cell Exhaustion	A useful method of gastric cancer stem cell (CSC) characterization is spheroid colony formation.	27459100
Behavior of tumor, Childhood Breast Carcinoma	Stem Cell Exhaustion	Spindle-shaped stromal cells, like carcinoma-associated fibroblasts and mesenchymal stem cells, influence tumor behavior and can serve as parameters in the clinical diagnosis, therapy, and prognosis of early breast cancer.	27460086
Degenerative polyarthritis	Stem Cell Exhaustion	We assessed the clinical outcomes through osteoarthritis outcome score (KOOS) and the inflammatory response by quantifying mesenchymal stem cells in synovial fluid.	27462609
Osteoarthritis, Knee, Usual Severity Pain	Stem Cell Exhaustion	Intra-articular injections combined with intraosseous infiltrations of platelet rich plasma reduce pain and mesenchymal stem cells in synovial fluid, besides significantly improving knee joint function in patients with severe knee osteoarthritis.	27462609
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease after radiation therapy in patients who have undergone allogeneic stem cell transplantation: two case reports.	27465468
Graft-vs-Host Disease	Stem Cell Exhaustion	Patients who undergo allogeneic stem cell transplantation and subsequent radiation therapy uncommonly develop graft-versus-host disease within the irradiated area.	27465468
Hodgkin Disease	Stem Cell Exhaustion	The first patient is a 37-year-old white man who had Hodgkin lymphoma; he underwent allogeneic stem cell transplantation from a matched unrelated donor and received radiation therapy for an abdominal and pelvic nodal recurrence.	27465468
Acute leukemia	Stem Cell Exhaustion	The other patient is a 24-year-old white man who had acute leukemia; he underwent allogeneic stem cell transplantation from a matched related donor and received craniospinal irradiation for a central nervous system relapse.	27465468
Graft-vs-Host Disease	Stem Cell Exhaustion	We conclude that graft-versus-host disease within irradiated tissues is an uncommon but potentially serious complication that may follow radiation therapy in patients who have undergone allogeneic stem cell transplantation.	27465468
Inflammation	Stem Cell Exhaustion	Patients who have undergone allogeneic stem cell transplantation represent a unique population that may offer novel insight into the pathways involved in radiation-related inflammation.	27465468
FLT3 Internal Tandem Duplication, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	FLT3/ITD+ AML cases were sorted into two putative LSC populations according to the expression of CD123 and analyzed for FLT3/ITD again in the stem cell fractions CD34+/CD38-/CD123+ and CD34+/CD38-/CD123-.	27465508
leukemia	Stem Cell Exhaustion	Xenograft transplantation studies have demonstrated a rare population of leukemia-initiating cells called leukemic stem cells (LSCs) capable of propagating leukemia that are enriched in the CD34+/CD38- fraction.	27465508
Broca Aphasia	Stem Cell Exhaustion	Severe motor aphasia after reinfusion of cryopreserved autologous stem cells after myeloablative conditioning.	27465621
Specialty Type - cancer, Pancreatic carcinoma	Stem Cell Exhaustion	Double cortin-like kinase 1 (DCLK1) is a promising therapeutic target and cancer stem cell marker, predominantly investigated in pancreatic and colorectal cancer.	27470117
Malignant neoplasm of salivary gland, Specialty Type - cancer	Stem Cell Exhaustion	Therefore, little is known about biomarkers and cancer stem cells in salivary gland malignancies.	27470117
Cytomegalovirus Infections, Graft-vs-Host Disease	Stem Cell Exhaustion	Therefore, we retrospectively studied the impact of latent or active CMV infections on the outcome and occurrence of graft-versus-host disease (GVHD) after reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (SCT) in 294 patients during the period from 2004 to 2010.	27470287
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We carried out post-transplantation cyclophosphamide (PTCy)-based haploidentical peripheral blood stem cell transplantation in 51 patients with refractory/relapsed acute myeloid leukemia not in remission.	27470289
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Our study shows that early administration of G-DLI is feasible after PTCy-based haploidentical hematopoietic stem cell transplantation for refractory/relapsed acute myeloid leukemia and might be associated with improved survival after MAC.	27470289
Decreased platelet count	Stem Cell Exhaustion	Platelet-Derived Growth Factor-BB Protects Mesenchymal Stem Cells (MSCs) Derived From Immune Thrombocytopenia Patients Against Apoptosis and Senescence and Maintains MSC-Mediated Immunosuppression.	27471307
Impaired	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) from ITP patients (MSC-ITP) do not exhibit conventional proliferative abilities and thus exhibit defects in immunoregulation, suggesting that MSC impairment might be a mechanism involved in ITP.	27471307
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Pretransplant NPM1 MRD levels predict outcome after allogeneic hematopoietic stem cell transplantation in patients with acute myeloid leukemia.	27471865
Acute myeloid leukemia with mutated NPM1	Stem Cell Exhaustion	The objective was to evaluate the prognostic impact of pre-transplant minimal residual disease (MRD) as determined by real-time quantitative polymerase chain reaction in 67 adult NPM1-mutated acute myeloid leukemia patients receiving allogeneic hematopoietic stem cell transplantation (HSCT).	27471865
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	First-line therapy of peripheral T-cell lymphoma: extension and long-term follow-up of a study investigating the role of autologous stem cell transplantation.	27471868
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Current guidelines recommend consolidation with autologous stem cell transplantation (autoSCT) after induction chemotherapy for most patients with peripheral T-cell lymphoma (PTCL).	27471868
Hodgkin Disease	Stem Cell Exhaustion	Brentuximab vedotin in relapsed/refractory Hodgkin lymphoma post-autologous stem cell transplant: a cost-effectiveness analysis in Scotland.	27472034
Hodgkin Disease	Stem Cell Exhaustion	To evaluate cost-effectiveness of brentuximab vedotin in patients with relapsed/refractory Hodgkin lymphoma who have received autologous stem cell transplantation, from a Scottish healthcare payer perspective.	27472034
Chronic Lymphocytic Leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment approach for patients with acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL).	27473564
Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	Cancer stem cells (CSCs) play a pivotal role in progression, metastasis and recurrence of cancer.	27473646
Failure, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	To evaluate the location and timing of initial recurrence in patients with diffuse large B-cell lymphoma (DLBCL) who subsequently underwent high-dose chemotherapy with autologous stem cell transplant (HDC/ASCT), to direct approaches for disease surveillance, elucidate the patterns of failure of contemporary treatment strategies, and guide adjuvant treatment decisions.	27473813
Hematologic Neoplasms	Stem Cell Exhaustion	Epigenetic alteration may play a role in age-associated dysfunction of stem cells and predispose to the development of hematological cancers.	27475703
Primary central nervous system lymphoma	Stem Cell Exhaustion	High-dose chemotherapy with autologous haemopoietic stem cell transplantation for newly diagnosed primary CNS lymphoma: a prospective, single-arm, phase 2 trial.	27476790
Crohn Disease, Perianal fistula	Stem Cell Exhaustion	Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial.	27477896
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Clinical Utility of Next-Generation Sequencing for Oncogenic Mutations in Patients with Acute Myeloid Leukemia Undergoing Allogeneic Stem Cell Transplantation.	27478011
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	To determine the association of somatic mutations in acute myeloid leukemia (AML) with risk of relapse after allogeneic hematopoietic stem cell transplantation (alloHSCT), we retrospectively studied pre-transplantation genetic profiles obtained from next-generation sequencing of 26 genes in 112 adult patients with AML who underwent alloHSCT.	27478011
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Protein kinase CK2 regulates AKT, NF-kB and STAT3 activation, stem cell viability and proliferation in acute myeloid leukemia.	27479180
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Protein kinase CK2 sustains acute myeloid leukemia cell growth, but its role in leukemia stem cells is largely unknown.	27479180
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Here, we discovered that the CK2 catalytic a and regulatory b subunits are consistently expressed in leukemia stem cells isolated from acute myeloid leukemia patients and cell lines.	27479180
leukemia	Stem Cell Exhaustion	CK2 inactivation with the selective inhibitor CX-4945 or RNA interference induced an accumulation of leukemia stem cells in the late S-G2-M phases of the cell cycle and triggered late-onset apoptosis.	27479180
leukemia	Stem Cell Exhaustion	As a result, leukemia stem cells displayed an increased sensitivity to the chemotherapeutic agent doxorubicin.	27479180
leukemia	Stem Cell Exhaustion	Notably, combined CK2 and either NF-kB or STAT3 inhibition resulted in a superior cytotoxic effect on leukemia stem cells.	27479180
Bacterial Infections	Stem Cell Exhaustion	Bacterial infections in pediatric hematopoietic stem cell transplantation recipients: incidence, epidemiology, and spectrum of pathogens: report of the Polish Pediatric Group for Hematopoietic Stem Cell Transplantation.	27479544
Graft-vs-Host Disease, Failure	Stem Cell Exhaustion	Infectious complications are a significant cause of hematopoietic stem cell transplantation (HSCT) failure, especially allogeneic HSCT (allo-HSCT) because of delayed immune reconstitution and graft-versus-host disease (GVHD) occurrence.	27479544
Viral respiratory infection	Stem Cell Exhaustion	Universal Mask Usage for Reduction of Respiratory Viral Infections After Stem Cell Transplant: A Prospective Trial.	27481873
Viral respiratory infection	Stem Cell Exhaustion	Respiratory viral infections (RVIs) are frequent complications of hematopoietic stem cell transplant (HSCT).	27481873
Multiple Myeloma	Stem Cell Exhaustion	Cost analysis of a randomized stem cell mobilization study in multiple myeloma.	27485453
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Upfront autologous stem cell transplantation (ASCT) is the standard therapy for younger multiple myeloma (MM) patients.	27485453
Specialty Type - cancer	Stem Cell Exhaustion	Children with a history of cancer and/or hematopoietic stem cell transplant had higher mortality (47% vs 11%; p < 0.001).	27487912
Respiratory Distress Syndrome, Newborn	Stem Cell Exhaustion	In the PICU, oxygenation index and cancer/hematopoietic stem cell transplant history can be used on acute respiratory distress syndrome day 1 or day 3 to predict hospital mortality without the need for more complex models.	27487912
Leukemia, Myelocytic, Acute, Acute leukemia	Stem Cell Exhaustion	The impact of HLA-matching on reduced intensity conditioning regimen unrelated donor allogeneic stem cell transplantation for acute myeloid leukemia in patients above 50 years-a report from the EBMT acute leukemia working party.	27488518
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Data comparing fully matched and mismatched-unrelated-donor (M- and mM-URD) allogeneic hematopoietic stem cell transplant (allo-SCT) following reduced intensity conditioning regimens for acute myeloid leukemia are limited.	27488518
Non-Small Cell Lung Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	The prognostic value of cancer stem cells (CSCs) marker CD133 in non-small-cell lung cancer (NSCLC) remains controversial.	27489355
Concomitant Medication Submission Domain, Degenerative polyarthritis	Stem Cell Exhaustion	We have investigated whether the conditioned medium (CM) from adipose-derived mesenchymal stem cells may regulate senescence features induced by inflammatory stress in OA chondrocytes.	27490266
Refractory angina	Stem Cell Exhaustion	RENEW (Efficacy and Safety of Targeted Intramyocardial Delivery of Auto CD34+ Stem Cells for Improving Exercise Capacity in Subjects With Refractory Angina) was a randomized, double-blind, multicenter trial comparing IM CD34(+) administration with no intervention (open-label standard of care) or IM placebo injections (active control).	27491607
Refractory angina	Stem Cell Exhaustion	(Efficacy and Safety of Targeted Intramyocardial Delivery of Auto CD34(+) Stem Cells for Improving Exercise Capacity in Subjects With Refractory Angina [RENEW]: NCT01508910).	27491607
leukemia	Stem Cell Exhaustion	Achieving Molecular Remission before Allogeneic Stem Cell Transplantation in Adult Patients with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Impact on Relapse and Long-Term Outcome.	27492792
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	Allogeneic stem cell transplantation (alloHSCT) in first complete remission (CR1) remains the consolidation therapy of choice in Philadelphia-positive (Ph+) acute lymphoblastic leukemia (ALL).	27492792
Streptococcus viridans, Allogeneic Hematopoietic Stem Cell Transplant Recipient	Stem Cell Exhaustion	Breakthrough viridans streptococcal bacteremia in allogeneic hematopoietic stem cell transplant recipients receiving levofloxacin prophylaxis in a Japanese hospital.	27495798
T-Cell Large Granular Lymphocyte, Large granular lymphocyte, leukemia	Stem Cell Exhaustion	T-cell large granular lymphocytic (T-LGL) leukemia after hematopoietic stem cell transplantation (SCT) is rare and its natural history and clinical outcome have not been well described.	27496109
leukemia	Stem Cell Exhaustion	Azacitidine Use After Allogeneic Stem Cell Transplantation-Results From the Polish Adult Leukemia Group.	27496495
Failure, Hematological Disease	Stem Cell Exhaustion	Relapse of primary hematologic disease constitutes an important reason for failure of allogeneic hematopoietic stem cell transplantation (alloHSCT).	27496495
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Autologous Hematopoietic Stem Cell Transplantation for Adults With Acute Myeloid Leukemia.	27496498
Acute leukemia	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) remains the most efficacious therapy in patients with acute leukemia.	27496498
Keratopathy, Corneal leukoma, Keratitis, Fuchs Endothelial Dystrophy, Keratoconus	Stem Cell Exhaustion	The major indications and their respective overall percentage were corneal leucoma (24%), pseudophakic/aphakic bullous keratopathy (22%), Fuchs dystrophy (13%), keratoconus (13%), re-graft (11%), keratitis (9%), and limbal stem cell deficiency (8%), with changes in relative frequency of the leading indications over the following time intervals.	27496499
Malignant Neoplasms, Hereditary	Stem Cell Exhaustion	Identifying Inherited and Acquired Genetic Factors Involved in Poor Stem Cell Mobilization and Donor-Derived Malignancy.	27497531
Hematological Disease	Stem Cell Exhaustion	Analysis of the clinical characteristics of hematopoietic stem cell transplant (HSCT) donors has proven beneficial for identifying cases of heritable hematopoietic disorders.	27497531
Myeloid neoplasm	Stem Cell Exhaustion	This study examines poor peripheral blood hematopoietic stem cell mobilization after granulocyte colony-stimulating factor administration among 328 donors as a potential marker for suspected familial predisposition to myeloid malignancies.	27497531
Ischemic stroke	Stem Cell Exhaustion	Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study.	27497862
Dermatomyositis, Polymyositis	Stem Cell Exhaustion	Dysfunction of endothelial progenitor cells is associated with the type I IFN pathway in patients with polymyositis and dermatomyositis.	27498356
Atrial Fibrillation by ECG Finding	Stem Cell Exhaustion	Reduction of c-kit positive cardiac stem cells in patients with atrial fibrillation.	27499271
Atrial Fibrillation by ECG Finding	Stem Cell Exhaustion	We aimed to determine expression patterns of cardiac stem cells in the left atrium (LA) tissue from patients with atrial fibrillation.	27499271
Hematologic Neoplasms	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HSCT) is potentially curative in a variety of hematological malignancies.	27502249
Cytomegalovirus Infections	Stem Cell Exhaustion	Accurate determination of recipient cytomegalovirus (CMV) serostatus before allogeneic hematopoietic stem cell transplantation (HSCT) is critical, as it is the most important predictor of post-transplant CMV infection and remains associated with non-relapse mortality.	27502917
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Phase I study of azacitidine following donor lymphocyte infusion for relapsed acute myeloid leukemia post allogeneic stem cell transplantation.	27505705
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Donor lymphocyte infusion (DLI) without prophylactic immunosuppression has been used for relapsed AML after allogeneic stem cell transplant (allo-SCT).	27505705
Limbal stem cell deficiency	Stem Cell Exhaustion	The present study aimed to investigate the clinical outcomes of autologous cultivated oral mucosal epithelial transplantation (COMET) on human amniotic membrane (AM) for corneal limbal stem cell deficiency (LSCD).	27507558
Adult T-Cell Lymphoma/Leukemia	Stem Cell Exhaustion	Allogeneic hematopoietic stem-cell transplantation (allo-HSCT) is one important treatment option for patients with aggressive adult T-cell leukemia/lymphoma (ATLL).	27507878
Multiple Myeloma	Stem Cell Exhaustion	The expression of 10 HDACs (including HDAC class I and II) was studied by quantitative reverse transcriptionPCR (qRTPCR) in a cohort of mesenchymal stem cells (MMMSCs) from 10 multiple myeloma patients with a median age 60y.	27510016
Atherosclerosis	Stem Cell Exhaustion	At baseline, at the end of treatment and six months after atorvastatin withdrawal, disease activity, subclinical atherosclerosis -assessed by measuring carotid-femoral pulse wave velocity (PWV) - and quantification of circulating endothelial progenitor cells (EPC) - as a surrogate biological marker of subclinical atherosclerosis - were carried out.	27510602
Scleroderma	Stem Cell Exhaustion	Establishment and gene expression analysis of disease-derived induced pluripotent stem cells of scleroderma.	27510999
Osteoporosis	Stem Cell Exhaustion	KDM5A controls bone morphogenic protein 2-induced osteogenic differentiation of bone mesenchymal stem cells during osteoporosis.	27512956
JAK2 NP_004963.1:p.V617F, Adenocarcinoma, MYELOPROLIFERATIVE SYNDROME, TRANSIENT	Stem Cell Exhaustion	During her clinical history, she had received an allogeneic, HLA-identical stem cell transplant for myeloproliferative syndrome with a JAK2V617F mutation and lobectomy of the pulmonary right lower lobe for adenocarcinoma.	27513936
Inflammation, "Alzheimers Disease	Stem Cell Exhaustion	Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer's disease.	27514990
Up	Stem Cell Exhaustion	Here we have used a human induced pluripotent stem cell (iPSC) model of familial and sporadic AD, in addition to healthy controls, to assess the neuroprotective activity of apigenin.	27514990
Memory Loss, Up, Cerebral atrophy, "Alzheimers Disease	Stem Cell Exhaustion	Activin A secreted by human mesenchymal stem cells induces neuronal development and neurite outgrowth in an in vitro model of Alzheimer's disease: neurogenesis induced by MSCs via activin A. Alzheimer's disease (AD) is characterized by progressive loss of memory in addition to cortical atrophy.	27515053
Up	Stem Cell Exhaustion	The aim of this study was to activate the neurogenesis in the SVZ of AD brains by human mesenchymal stem cells (hMSCs).	27515053
Metabolic Syndrome X, Acute leukemia	Stem Cell Exhaustion	Metabolic syndrome in long-term survivors of childhood acute leukemia treated without hematopoietic stem cell transplantation: an L.E.A.	27515247
Cardiovascular Diseases, Metabolic Syndrome X	Stem Cell Exhaustion	However, few studies have investigated the risk of metabolic syndrome, a known predictor of cardiovascular disease, in patients treated without hematopoietic stem cell transplantation.	27515247
Acute leukemia	Stem Cell Exhaustion	(Leucemie de l'Enfant et de l'Adolescent) French cohort of childhood acute leukemia survivors treated without hematopoietic stem cell transplantation.	27515247
Metabolic Syndrome X, Acute leukemia	Stem Cell Exhaustion	Survivors of childhood acute leukemia are at risk of metabolic syndrome, even when treated without hematopoietic stem cell transplantation or central nervous system irradiation.	27515247
Neoplasms	Stem Cell Exhaustion	Double immunostaining for CK5/6 and Ki-67 revealed that most of Ki-67-positive proliferating tumor cells were CK5/6-positive, suggesting that CK5/6-positive population contained proliferative progenitor cells of the tumor.	27516039
Adenolymphoma, Neoplasms, Multinodular oncocytic hyperplasia	Stem Cell Exhaustion	These findings imply that the regional difference in the distribution pattern and proliferative activity of CK5/6-positive putative progenitor cells along with the difference in the pattern of vascular network occurred during the tumorigenic process of the tumor and determined one region to become conventional Warthin's tumor morphology and the other to become nodular oncocytic hyperplasia.	27516039
T-Cell Prolymphocytic Leukemia	Stem Cell Exhaustion	He had been diagnosed with T-cell prolymphocytic leukemia 4 years earlier and had undergone matched-unrelated-donor stem cell transplant 2 years earlier; on admission, he had relapsed disease.	27516534
Neoplasms, Multiple Myeloma	Stem Cell Exhaustion	Although several transcriptome analyses of myeloma patient-derived mesenchymal stem cells have displayed differences compared to their healthy counterparts, these analyses insufficiently reflect the signatures mediated by tumor cell contact, vary due to different methodologies, and lack results in lineage-committed precursors.	27519972
Neoplasms	Stem Cell Exhaustion	To determine tumor cell contact-mediated changes on skeletal precursors, we performed transcriptome analyses of mesenchymal stem cells and osteogenic precursor cells cultured in contact with the myeloma cell line INA-6.	27519972
Chronic myeloproliferative disorder	Stem Cell Exhaustion	The effects of hematopoietic stem cell transplant on splenic extramedullary hematopoiesis in patients with myeloproliferative neoplasm-associated myelofibrosis.	27521149
Chronic myeloproliferative disorder	Stem Cell Exhaustion	Hematopoietic stem cell transplant (HSCT) is the only curative treatment for myeloproliferative neoplasm-associated myelofibrosis (MPN-MF).	27521149
Lymphoma	Stem Cell Exhaustion	The Prognostic Significance of Elevated Serum Ferritin Levels Prior to Transplantation in Patients With Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation (autoHSCT): Role of Iron Overload.	27521313
Lymphoma	Stem Cell Exhaustion	Hematopoietic stem cell transplantation is a common and preferred treatment of lymphomas in many centers.	27521313
Hematologic Neoplasms	Stem Cell Exhaustion	Comparative Outcomes after Haploidentical or Unrelated Donor Bone Marrow or Blood Stem Cell Transplantation in Adult Patients with Hematological Malignancies.	27522040
Primary Myelofibrosis, PMF Regimen	Stem Cell Exhaustion	A combination of low-dose thalidomide and corticosteroids is a treatment option for anaemic patients with primary myelofibrosis (PMF) who are not eligible for allogeneic hematopoietic stem cell transplantation.	27526305
Specialty Type - cancer	Stem Cell Exhaustion	IVE might express a cancer stem cell (CSC) phenotype.	27528226
Adult Glioblastoma	Stem Cell Exhaustion	Sox2, a stemness gene, regulates tumor-initiating and drug-resistant properties in CD133-positive glioblastoma stem cells.	27530866
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	These cancer stem cells (CSCs) promote the potency of tumor initiation.	27530866
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	As a result, targeting of glioma stem cells has become the dominant way of improving the therapeutic outcome against GBM and extending the life span of patients.	27530866
Toxoplasmosis	Stem Cell Exhaustion	Clinical characteristics and computed tomography findings of pulmonary toxoplasmosis after hematopoietic stem cell transplantation.	27531150
Toxoplasmosis	Stem Cell Exhaustion	The prognosis of pulmonary toxoplasmosis, including disseminated toxoplasmosis involving the lungs, following hematopoietic stem cell transplantation (HSCT) is extremely poor due to the difficulties associated with early diagnosis and the rapidly progressive deterioration of multiorgan function.	27531150
Adult Glioblastoma	Stem Cell Exhaustion	Sensitivity to PRIMA-1MET is associated with decreased MGMT in human glioblastoma cells and glioblastoma stem cells irrespective of p53 status.	27533246
leukemia, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We report a clinical observation of TKIs cessation in Chinese CML patients and a probable connection between CML leukemia stem cells (LSCs) and relapse.	27533462
Adenoma	Stem Cell Exhaustion	Our findings showed the existence of cells that are phenotypically intermediate between ganglion cells and adenoma cells, and the existence of stem cell-like cells, which support the hypothesis that adenoma cells can transform into ganglion cells or that both ganglion and adenoma cells derive from common stem cells.	27535625
Graft-vs-Host Disease	Stem Cell Exhaustion	The cumulative incidence of neutrophil and platelet engraftment of the study cohort was compared to that of a cohort of 95 allogeneic peripheral blood stem cell transplant recipients treated during the same period of time and who received similar conditioning and graft-versus-host disease prophylaxis.	27535663
Neuroendocrine Tumors, Paraganglioma, Adrenal Gland Pheochromocytoma, SDHD wt Allele	Stem Cell Exhaustion	Pheochromocytomas (PCC) and paragangliomas (PGL) are neuroendocrine tumours arising from pluripotent neural crest stem cells and are associated with neurons of the autonomic nervous system.	27535829
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	An operational definition of primary refractory acute myeloid leukemia allowing early identification of patients who may benefit from allogeneic stem cell transplantation.	27540133
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Furthermore, these data demonstrate that allogeneic stem cell transplantation represents an effective therapeutic modality in selected patients with primary refractory acute myeloid leukemia.	27540133
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Our aim was to improve outcome prediction after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia by combining cytogenetic and molecular data at diagnosis with minimal residual disease assessment by multicolor flow-cytometry at transplantation.	27540139
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Assessment of minimal residual disease at transplantation in combination with cytogenetic and molecular findings provides powerful independent prognostic information in acute myeloid leukemia, lending support to the incorporation of minimal residual disease detection to refine risk stratification and develop a more individualized approach during hematopoietic stem cell transplantation.	27540139
Specialty Type - cancer	Stem Cell Exhaustion	The current treatment regimens are ineffective against the small population of cancer stem cells residing in the tumourigenic niche; however, a new therapeutic approach could involve the removal of these cells from the microenvironment that maintains the cancer stem cell phenotype.	27541285
Specialty Type - cancer	Stem Cell Exhaustion	GSCs adherence on fibronectin is mediated by a5b1 integrin, where fibronectin further promotes GSC migration and is an effective candidate for in vivo cancer stem cell migration out of the tumourigenic niche.	27541285
Specialty Type - cancer	Stem Cell Exhaustion	Our results suggest that therapies against ADAM10 and ADAM17 may promote cancer stem cell migration away from the tumourigenic niche resulting in a differentiated phenotype that is more susceptible to treatment.	27541285
Avascular necrosis, tacrine, Avascular Necrosis, CTCAE, Degenerative polyarthritis	Stem Cell Exhaustion	As patients who receive hematopoietic stem cell transplantation are at increased risk of avascular necrosis (AVN) and subsequent degenerative arthritis, THA may be considered in some of these patients, particularly as overall patient survival improves for patients undergoing stem-cell transplants.	27542147
GDC Comorbidity Terminology, Communicable Diseases	Stem Cell Exhaustion	Patients receiving hematopoietic stem cell transplantation theoretically are at increased risk of experiencing complications, infection, and poorer implant survivorship owing to the high prevalence of comorbid conditions, immunosuppressive therapy regimens including corticosteroids, and often low circulating hematopoietic cell lines; however, there is a paucity of studies elucidating these risks.	27542147
Disease, Lymphoma, Amyloidosis, leukemia, primary disorders	Stem Cell Exhaustion	Underlying primary diseases leading to hematopoietic stem cell transplantation included lymphoma (14/42; 33%), plasma cell disorders (10/42; 24%), leukemia (9/42; 21%), and amyloidosis (3/42; 7%).	27542147
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Antineoplastic effects and mechanisms of micheliolide in acute myelogenous leukemia stem cells.	27542251
leukemia	Stem Cell Exhaustion	Leukemic stem cells (LSCs) greatly contribute to the initiation, relapse, and multidrug resistance of leukemia.	27542251
Limbal stem cell deficiency	Stem Cell Exhaustion	This study addresses important issues regarding possible risks associated with disarray of the ocular surface homeostasis following autologous CLET in patients with limbal stem cell deficiency, despite the fact that the majority of patients experienced a favourable long-term benefit.	27543289
Fibrosis, Liver	Stem Cell Exhaustion	HuR mediates motility of human bone marrow-derived mesenchymal stem cells triggered by sphingosine 1-phosphate in liver fibrosis.	27543493
fibrogenesis	Stem Cell Exhaustion	Sphingosine 1-phosphate (S1P) participates in migration of bone marrow (BM)-derived mesenchymal stem cells (BMSCs) toward damaged liver via upregulation of S1P receptor 3 (S1PR3) during mouse liver fibrogenesis.	27543493
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GVHD) remains a major problem of allogeneic hematopoietic-stem cell transplantation (HSCT) and an obstacle for successful outcome.	27546540
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We compared overall survival (OS) of 1017 patients with newly diagnosed multiple myeloma (MM) who were treated with different novel agent-based induction regimens and who underwent early autologous stem cell transplant (ASCT).	27548464
Aplastic Anemia	Stem Cell Exhaustion	The Latin American experience of allografting patients with severe aplastic anaemia: real-world data on the impact of stem cell source and ATG administration in HLA-identical sibling transplants.	27548465
melanoma, Neoplasms	Stem Cell Exhaustion	Ipi-Bev also augmented humoral immune responses recognizing targets in melanoma, tumor endothelial, and tumor mesenchymal stem cells.	27549123
Carcinogenic Chlorinated Hydrocarbon, Hollings Cancer Center	Stem Cell Exhaustion	Consistent with this finding, immunohistochemical analysis revealed that hepatocyte markers (Hep Par 1 and GPC3) and cholangiocyte markers (CK7 and CK19) were simultaneously expressed in both the HCC and ICC components in 52.9% of CHC specimens, suggesting that the two components shared a similar phenotype with hepatic progenitor cells (HPCs).	27552844
Malignant neoplasm of stomach, Specialty Type - cancer	Stem Cell Exhaustion	Clinical significance of putative markers of cancer stem cells in gastric cancer: A retrospective cohort study.	27557490
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSCs) are thought as the source of tumor maintaining and many CSCs markers have been identified.	27557490
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	RhoGDIa suppresses self-renewal and tumorigenesis of glioma stem cells.	27557508
Glioblastoma Multiforme Pathway, Neoplasms	Stem Cell Exhaustion	Glioma stem cells (GSCs) are a subset of tumor cells that drive glioma initiation and progression.	27557508
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	RhoGDIa was down-regulated in glioma stem cells.	27557508
Respiratory Failure	Stem Cell Exhaustion	Respiratory Failure in a Woman 8 Months After an Allogeneic Stem Cell Transplant.	27559706
Corneal Endothelial Cell Loss	Stem Cell Exhaustion	Although rare, circulating endothelial and progenitor cells could be considered as markers of endothelial damage and repair potential, possibly predicting the severity of cardiovascular manifestations.	27560136
Ectopic calcification, "cytidylyl-(3-5)-cytidine	Stem Cell Exhaustion	Circulating mature cells (CMC, CD45-, CD34+, CD133-) and circulating progenitor cells (CPC, CD45dim, CD34bright, CD133+) were investigated by polychromatic high-speed flow cytometry to detect the expression of endothelial (CD309+) or osteogenic (BAP+) differentiation markers in healthy subjects and in patients affected by peripheral vascular manifestations associated with ectopic calcification.	27560136
Hemopoietic stem cell transplant	Stem Cell Exhaustion	Moreover, the patients with >10^-4 MRD level before the start of HSCT (hematopoietic stem cell transplantation) had worse prognosis and higher risk of relapse compared to patients with <=10^-4 before the start of HSCT.	27561414
Lymphoma	Stem Cell Exhaustion	Relapse risk after autologous stem cell transplantation in patients with lymphoma based on CD34+ cell dose.	27561733
Carcinogenesis	Stem Cell Exhaustion	Canonical Wnt/b-catenin signalling is essential for maintaining intestinal stem cells, and its constitutive activation has been implicated in colorectal carcinogenesis.	27562646
Colorectal Carcinoma	Stem Cell Exhaustion	TNIK is required for the tumour-initiating function of colorectal cancer stem cells.	27562646
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Preclinical investigation of ibrutinib, a Bruton's kinase tyrosine (Btk) inhibitor, in suppressing glioma tumorigenesis and stem cell phenotypes.	27564106
Acute GVH disease	Stem Cell Exhaustion	This secondary analysis of a large, multicenter Blood and Marrow Transplant Clinical Trials Network randomized trial assessed whether patient-reported outcomes (PROs) and socioeconomic status (SES) before hematopoietic stem cell transplantation (HCT) are associated with each other and predictive of clinical outcomes, including time to hematopoietic recovery, acute graft-versus-host disease, hospitalization days, and overall survival (OS) among 646 allogeneic and autologous HCT recipients.	27565521
Degenerative polyarthritis	Stem Cell Exhaustion	Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: multicenter randomized controlled clinical trial (phase I/II).	27565858
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation (AuHSCT) is standard in treating eligible multiple myeloma (MM) patients.	27566569
Specialty Type - cancer, Gastritis	Stem Cell Exhaustion	In this study, we report the significance of an elevation of the stem cell regulator SOX9 in bacteria-infected human gastritis and cancer samples, paralleling increased levels of TNFa SOX9 elevation was more intense in specimens containing the pathogenically significant cagA+ strains of H. pylori Notably, we found that SOX9 was required for bacteria-induced gastric cancer cell proliferation, increased levels of b-catenin, and acquisition of stem cell-like properties.	27569216
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	The patient, a 52-year-old woman, received chemotherapy and autologous peripheral blood stem cell transplantation for relapsed diffuse large B-cell lymphoma (DLBCL).	27569297
Lymphoma, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	This was the first case of EBVMCU characterized by both an association with autologous peripheral blood stem cell transplantation and subsequent emergence of malignant lymphoma in a patient with relapsed DLBCL.	27569297
leukemia	Stem Cell Exhaustion	RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML.	27570067
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Age-related human hematopoietic stem cell (HSC) exhaustion and myeloid-lineage skewing promote oncogenic transformation of hematopoietic progenitor cells into therapy-resistant leukemia stem cells (LSCs) in secondary acute myeloid leukemia (AML).	27570067
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Comprehensive RNA sequencing and splice-isoform-specific PCR uncovered characteristic RNA splice isoform expression patterns that distinguished normal young and aged human stem and progenitor cells (HSPCs) from malignant myelodysplastic syndrome (MDS) and AML progenitors.	27570067
Multiple Myeloma	Stem Cell Exhaustion	Treatment response evaluation with 18F-FDG PET/CT and 18F-NaF PET/CT in multiple myeloma patients undergoing high-dose chemotherapy and autologous stem cell transplantation.	27573638
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The aim of this study was to assess the combined use of the radiotracers 18F-FDG and 18F-NaF in treatment response evaluation of a group of multiple myeloma (MM) patients undergoing high-dose chemotherapy (HDT) followed by autologous stem cell transplantation (ASCT) by means of static (whole-body) and dynamic PET/CT (dPET/CT).	27573638
Graft-vs-Host Disease	Stem Cell Exhaustion	In this context, pretransplant treatment with MOG may induce severe graft-versus-host disease (GVHD) in allogeneic hematopoietic stem-cell transplantation (HSCT).	27573760
Burn injury	Stem Cell Exhaustion	As part of the strategies for the management of severe cases, there is an ongoing research and development protocol on 'Translational Clinical Trial phases I/II to evaluate the safety and efficacy of adult mesenchymal stem cells from bone marrow for the treatment of large burns and radiological lesions'.	27574323
Hepatic Veno-Occlusive Disease	Stem Cell Exhaustion	Hepatic veno-occlusive disease, also called sinusoidal obstruction syndrome (VOD/SOS), is an unpredictable, potentially life-threatening complication of hematopoietic stem cell transplant conditioning.	27574402
Lymphoma	Stem Cell Exhaustion	Phase II Study of Propylene Glycol-Free Melphalan Combined with Carmustine, Etoposide, and Cytarabine for Myeloablative Conditioning in Lymphoma Patients Undergoing Autologous Stem Cell Transplantation.	27575541
Lymphoma	Stem Cell Exhaustion	These results demonstrate that PG-free melphalan can be used in place of the standard, lyophilized formulation of melphalan in the BEAM regimen for lymphoma patients undergoing autologous stem cell transplantation.	27575541
Thalassemia	Stem Cell Exhaustion	One-year results from a prospective randomized trial comparing phlebotomy with deferasirox for the treatment of iron overload in pediatric patients with thalassemia major following curative stem cell transplantation.	27576370
Hypernatremia, Thalassemia	Stem Cell Exhaustion	Iron overload is well documented in patients with b-thalassemia major, and patients who have undergone hematopoietic stem cell transplantation (HSCT) remain at risk as a result of pre- and immediate post-HSCT transfusions.	27576370
methyldopa	Stem Cell Exhaustion	We found that interactions between SNPs with highest AMD association were epigenetically active in the liver, adipocytes, and mesenchymal stem cells.	27576376
Evans syndrome, Hodgkin Disease	Stem Cell Exhaustion	Evans syndrome after autologous peripheral blood stem cell transplantation for recurrent Hodgkin lymphoma.	27577012
Evans syndrome, Hodgkin Disease	Stem Cell Exhaustion	We describe a rare case of Evans syndrome (ES) that developed in a 16-year-old patient >1 year after autologous peripheral blood stem cell transplantation for recurrent Hodgkin lymphoma.	27577012
Specialty Type - cancer	Stem Cell Exhaustion	Gender, cancer diagnosis, radiation therapy, anthracycline exposure, and hematopoietic stem cell transplant were not significantly associated with adherence.	27578608
Amyloidosis	Stem Cell Exhaustion	Combination therapy with high-dose melphalan and autologous stem cell transplantation was performed according to the regimen for AL amyloidosis.	27580556
Cancer/Testis Antigen	Stem Cell Exhaustion	The expression of cancer testis antigen MAGE C1 has been linked to the malignant stem cell in this disease, and thus, we investigated the use of both flow cytometric and qRTPCR approaches to monitor its expression as an alternative monitoring methodology in this pilot study.	27581737
Specialty Type - cancer	Stem Cell Exhaustion	Cancer testis antigen MAGE C1 can be used to monitor levels of circulating malignant stem cells in the peripheral blood of multiple myeloma patients.	27581737
Multiple Myeloma	Stem Cell Exhaustion	Evaluation of in vitro effects of various targeted drugs on plasma cells and putative neoplastic stem cells in patients with multiple myeloma.	27582537
Fever, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Skin Lesions and Recurrent Fever in Acute Myeloid Leukemia Patient Treated With Allogeneic Stem Cell Transplant.	27583691
Social security number, Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cell markers are not much explored in the cases of OSSN.	27584160
Social security number	Stem Cell Exhaustion	In the present study, we aim to evaluate the expression of stem cells using stem cell markers mainly p63, ABCG2, c-KIT (CD117) and CD44 in OSSN tissue, which could have prognostic significance.	27584160
Specialty Type - cancer, Neoplasms, CDISC SDTM Lesion Complexity Terminology	Stem Cell Exhaustion	Recent findings on cancer stem cells theory indicate that population of stem-like cell as in neoplasia determines its heterogeneity and complexity leading to varying tumor development of metastatic behavior and recurrence.	27584160
Social security number	Stem Cell Exhaustion	Our results show for the first time that these four stem cells especially the limbal epithelium stem cells play a vital role in the genesis of OSSN but we need to explore more cases before establishing its clinical and biological significance.	27584160
Multiple Myeloma	Stem Cell Exhaustion	Outcome with lenalidomide plus dexamethasone followed by early autologous stem cell transplantation in patients with newly diagnosed multiple myeloma on the ECOG-ACRIN E4A03 randomized clinical trial: long-term follow-up.	27588519
Multiple Myeloma	Stem Cell Exhaustion	In Eastern Cooperative Oncology Group-ACRIN E4A03, on completion of four cycles of therapy, newly diagnosed multiple myeloma patients had the option of proceeding to autologous peripheral blood stem cell transplant (ASCT) or continuing on their assigned therapy lenalidomide plus low-dose dexamethasone (Ld) or lenalidomide plus high-dose dexamethasone (LD).	27588519
Neoplasms	Stem Cell Exhaustion	Within GBM exists a subpopulation of cells, glioblastoma-initiating cells (GIC), which possess the characteristics of progenitor cells, have the ability to initiate tumour growth and resist to current treatment strategies.	27589691
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Matched and mismatched unrelated donor compared to autologous stem cell transplantation for acute myeloid leukemia in first complete remission: a retrospective, propensity score-weighted analysis from the ALWP of the EBMT.	27589849
Neoplasms	Stem Cell Exhaustion	The current study was planned to gain insight into its molecular genetics using a targeted next-generation sequencing approach and to explore the status of epithelial-mesenchymal transition (EMT)-associated markers (E-/P-/N-cadherins, MMP-2/-9 and caveolin-1), downstream transcriptional regulators of EMT-related signaling pathways (ZEB-1/-2, Slug), stem cell factors (Oct3/4, LIN28, SOX2, SO17, NANOG, CD133, nestin), and markers of adrenocortical origin/tumorigenesis (SF-1, b-catenin, p53) in phenotypically diverse tumor components of 6 cases.	27589897
Neoplasms	Stem Cell Exhaustion	These tumors are enriched for EMT-related markers and stem cell factors, potentially conferring a poor prognosis, which might be exploited as novel therapeutic targets.	27589897
Multiple Myeloma	Stem Cell Exhaustion	Escalating doses of bortezomib with high-dose melphalan was evaluated as as a conditioning regimen for autologous stem cell transplantation (ASCT) in patients with relapsed or refractory multiple myeloma (MM).	27590107
Pathology	Stem Cell Exhaustion	Cell replacement and regenerative therapy using embryonic stem cell-derived material holds promise for the treatment of several pathologies.	27590276
Experimental Organism Basal Cell Carcinoma, Malignant Neoplasms, Squamous cell carcinoma	Stem Cell Exhaustion	Evidence suggests that progenitor cells of keratinocyte cancers (basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)) may originate from epidermal stem cells including hair follicle stem cells.	27590883
Neoplasms	Stem Cell Exhaustion	Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) is a putative intestinal stem cell marker that is also expressed in various tumors.	27593551
Stomach Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	In intramucosal SRCC, the low mitotic activity of Lgr5-positive cells suggests that they may represent cancer stem cells as seen in other types of stomach carcinomas.	27593551
AIDS-Related Hodgkin Lymphoma	Stem Cell Exhaustion	Outcomes of autologous stem cell transplantation (ASCT) in patients with relapsed/refractory HIV-associated lymphoma.	27595283
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	This study investigated the long-term effect of adding bendamustine to a conditioning regimen on survival, rate of engraftment, immune recovery and GvHD after allogeneic stem cell transplantation (alloSCT) in CLL patients.	27595282
Acute leukemia	Stem Cell Exhaustion	Prevalence and risk factors of iron overload after hematopoietic stem cell transplantation for childhood acute leukemia: a LEA study.	27595286
Myeloid neoplasm	Stem Cell Exhaustion	Reduced-intensity conditioning (RIC) has been shown to have similar overall survival (OS) but higher relapse rates compared with myeloablative (MAC) regimens in patients with myeloid malignancies undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT).	27596129
Primary Myelofibrosis	Stem Cell Exhaustion	Outcome of Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Chronic and Advanced Phase Myelofibrosis.	27596130
Coronary microvascular dysfunction	Stem Cell Exhaustion	Circulating progenitor cells and coronary microvascular dysfunction: Results from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation - Coronary Vascular Dysfunction Study (WISE-CVD).	27596135
Ischemia	Stem Cell Exhaustion	Ischemia stimulates a reparative response resulting in mobilization of circulating progenitor cells (CPCs).	27596135
Specialty Type - cancer	Stem Cell Exhaustion	We then evaluated the expression levels of epithelial-mesenchymal transition (EMT)-related molecules (E-cadherin, S100A4), invasion-related molecules (laminin-5, ezrin), stem-cell-related molecules (ALDH-1), and growth factor receptors (c-Met, EGFR) in cancer cells of each group (n=20).	27597281
Intestinal Motility, Dominica, Diabetes Mellitus, Microcirculation disorders, Inflammation	Stem Cell Exhaustion	Clinical and experimental research has revealed that diabetes mellitus (DM) is characterized by intestinal hypomotility, gut microbial dysbiosis, increased gut permeability, microcirculation disorders, circulatory changes, and dysfunction of intestinal stem cells, which may be linked to inflammation of intestinal mucosa.	27598308
Epithelioma	Stem Cell Exhaustion	CD44, a major surface receptor for hyaluronic acid, has multiple isoforms and represents a major cancer stem cell marker for various epithelial tumors.	27599396
Hematologic Neoplasms	Stem Cell Exhaustion	Posaconazole Tablet Formulation at 400 Milligrams Daily Achieves Desired Minimum Serum Concentrations in Adult Patients with a Hematologic Malignancy or Stem Cell Transplant.	27600035
Hematologic Neoplasms, Mycoses	Stem Cell Exhaustion	We describe our experience using the posaconazole 400-mg delayed-release tablet formulation once daily in 20 patients with hematologic malignancy or hematopoietic stem cell transplant who were unable to attain prespecified target minimum serum (trough) concentrations for treatment or prophylaxis of invasive fungal infection.	27600035
Diabetes	Stem Cell Exhaustion	The present work investigates whether and by which mechanism diabetes negatively impacts on functional properties of muscular pericytes (MPs), which are resident stem cells committed to reparative angiomyogenesis.	27600065
Malignant neoplasm of stomach, Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	Recent progress in gastric cancer research has demonstrated the crucial roles of cancer stem cells (CSCs) in the development, metastasis, and drug resistance of this disease.	27602437
Lymphocyte Culture Test, Mixed, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	To enlighten interactions between autologous, allogeneic or T-cells from patients after stem cell transplantation with leukaemia-derived-dendritic-cells containing dendritic cells or blast containing mononuclear cells (n = 21, respectively), we determined cytokine-concentrations (interleukin 2, 4, 6, 10, tumor-necrosis-factor-a, interferon-g) in supernatants of mixed-lymphocyte-culture and in serum (n = 16) of 20 patients with acute myeloid leukaemia and three patients with myelodysplastic syndromes by cytometric-bead-assay.	27602789
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Leukemia stem cells (LSC) are responsible for the initiation and maintenance of AML due to their stem-cell properties.	27604463
Anemia	Stem Cell Exhaustion	Sf3b1K700E/+ animals had impaired erythropoiesis and progressive anemia without ringed sideroblasts, as well as reduced hematopoietic stem cell numbers and host-repopulating fitness.	27604819
Cryptorchidism, Stem Cell Factor	Stem Cell Exhaustion	Materials and Methods Histology sections from 373 testicular biopsies from 289 boys aged 1 month to 2 years operated for cryptorchidism were incubated with primary antibodies including anti-placental-like-alkaline phosphatase, antiOct-3/4, anti-C-kit, anti-D2-40, and in case of repeat biopsy with anti-stem cell factor (SCF) receptor.	27606906
Cerebrovascular accident	Stem Cell Exhaustion	Granulocyte Colony Stimulating Factor and Physiotherapy after Stroke: Results of a Feasibility Randomised Controlled Trial: Stem Cell Trial of Recovery EnhanceMent after Stroke-3 (STEMS-3 ISRCTN16714730).	27610616
Cerebrovascular accident	Stem Cell Exhaustion	Granulocyte-colony stimulating factor (G-CSF) mobilises endogenous haematopoietic stem cells and enhances recovery in experimental stroke.	27610616
Cytomegalovirus Infections	Stem Cell Exhaustion	Cytomegalovirus Infection and Treatment in Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective Study from a Single Institution in an Endemic Area.	27610628
Failure, Communicable Diseases	Stem Cell Exhaustion	Although Cytomegalovirus (CMV) infection is a major complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT), the risk factors for CMV reactivation and treatment failure in CMV endemic areas have remained unclear.	27610628
leukemia	Stem Cell Exhaustion	Aldehyde dehydrogenases inhibition eradicates leukemia stem cells while sparing normal progenitors.	27611922
Specialty Type - cancer, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Unravelling the relevance of CLEC12A as a cancer stem cell marker in myelodysplastic syndrome.	27612176
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Due to the absence of CLEC12A on normal haematopoietic stem cells, CLEC12A stem cell immunophenotyping may contribute to diagnosing and monitoring MDS patients and could furthermore add knowledge about disease propagating cells in MDS.	27612176
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Evidence of distinct disease propagating stem cells in myelodysplastic syndrome (MDS) has emerged in recent years.	27612176
Specialty Type - cancer	Stem Cell Exhaustion	However, immunophenotypic characterization of these cancer stem cells remains sparse.	27612176
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Furthermore, CLEC12A has been proposed as a promising marker of leukaemic stem cells in AML.	27612176
PAFAH1B1 wt Allele, Specialty Type - cancer, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	As opposed to reported findings in AML, we showed that cancer stem cells from MDS samples derived from both CLEC12A positive and negative CD34+ CD38- subpopulations.	27612176
Atherosclerosis, Hypoxia	Stem Cell Exhaustion	Adipose-derived mesenchymal stem cells from patients with atherosclerotic renovascular disease have increased DNA damage and reduced angiogenesis that can be modified by hypoxia.	27612459
CLU protein, human, Ischemia	Stem Cell Exhaustion	DM was highly prevalent in two recently conducted randomized controlled trials in CLI patients, the PADI (Percutaneous Transluminal Balloon Angioplasty [PTA] and Drug Eluting Stents for Infrapopliteal Lesions in Critical Limb Ischemia) and JUVENTAS (Rejuvenating Endothelial Progenitor Cells via Transcutaneous Intra-Arterial Supplementation) trials.	27612499
Multiple Myeloma	Stem Cell Exhaustion	Upfront autologous stem cell transplantation for newly diagnosed elderly multiple myeloma patients: a prospective multicenter study.	27612987
Multiple Myeloma	Stem Cell Exhaustion	The feasibility and efficacy of high-dose melphalan followed by autologous hematopoietic stem cell transplantation in newly diagnosed elderly patients with multiple myeloma was analyzed prospectively.	27612987
Multiple Myeloma	Stem Cell Exhaustion	This prospective study provides evidence for the safety and efficacy of autologous hematopoietic stem cell transplantation as a first-line treatment approach in elderly multiple myeloma patients.	27612987
Specialty Type - cancer, Thrombomodulin Alfa	Stem Cell Exhaustion	Immunohistochemical results from clinical tissue microarray (TMA) suggested that the expression concordance rates of cancer stem cells (CSCs) and drug resistance relative proteins between lymph-node metastatic and primary CRC foci were low.	27613840
Lymphoma	Stem Cell Exhaustion	Prospective noninterventional study on peripheral blood stem cell mobilization in patients with relapsed lymphomas.	27614935
Lymphoma	Stem Cell Exhaustion	High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) to rescue hematopoiesis is considered standard care for patients with a relapsed chemosensitive lymphoma, but diagnosis of lymphoma has been a risk factor for poor mobilization in several studies.	27614935
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Stem Cell Exhaustion	Multi-center analysis of the effect of T-cell acute lymphoblastic leukemia subtype and minimal residual disease on allogeneic stem cell transplantation outcomes.	27618682
Adult T-Cell Lymphoma/Leukemia, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Stem Cell Exhaustion	This study aims to provide a detailed analysis of allogeneic stem cell transplantation (allo-SCT) outcomes in a large T-cell acute lymphoblastic leukemia (T-ALL) cohort with a specific emphasis on the effects of pre-transplant minimal residual disease (MRD) and disease subtype, including the aggressive early-thymic precursor (ETP) subtype.	27618682
Specialty Type - cancer, Squamous cell carcinoma of the head and neck	Stem Cell Exhaustion	Identification, expansion and characterization of cancer cells with stem cell properties from head and neck squamous cell carcinomas.	27619333
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Recent data indicate the presence of cancer stem cells (CSC) in many solid tumors, including HNSCC.	27619333
Graft-vs-Host Disease, Anteroventral Thalamic Nucleus	Stem Cell Exhaustion	NV (59%), RV (74%) and AV (78%) were identified in hematopoietic stem cell transplant (HSCT) recipients; and in patients with graft versus host disease (GVHD): NV (34%), RV (46%) and AV (57%).	27620005
Stomach Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma.	27620279
Stomach Carcinoma, Specialty Type - cancer, Neoplasms, Primary Neoplasm	Stem Cell Exhaustion	This study aimed to characterize biomarkers allowing the detection of cancer stem cells (CSC) in human gastric carcinoma of different histologic types.Experimental Design: The primary tumors from 37 patients with intestinal- or diffuse-type noncardia gastric carcinoma were studied, and patient-derived tumor xenograft (PDX) models in immunodeficient mice were developed.	27620279
Alzheimers Disease	Stem Cell Exhaustion	Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes.	27622770
Up	Stem Cell Exhaustion	The advent of induced pluripotent stem cells (iPSCs) allows us to model pathology and study disease mechanisms directly in human neural cells from healthy individual as well as AD patients.	27622770
Up	Stem Cell Exhaustion	We report brain organoids that use pluripotent stem cells derived from AD patients and recapitulate AD-like pathologies such as amyloid aggregation, hyperphosphorylated tau protein, and endosome abnormalities.	27622770
MS gene	Stem Cell Exhaustion	In a group of 19 consecutive patients with multiple sclerosis given autografts, we employed granulocyte colony-stimulating factors to mobilize stem cells from the bone marrow to the peripheral blood, either the original granulocyte colony-stimulating factor (n = 10) or a Mexican granulocyte colony-stimulating factor biosimilar (n = 9).	27623036
leukemia	Stem Cell Exhaustion	The Total Body Irradiation Schedule Affects Acute Leukemia Relapse After Matched T Cell-Depleted Hematopoietic Stem Cell Transplantation.	27623308
Acute leukemia	Stem Cell Exhaustion	We sought to determine whether the total body irradiation (TBI) schedule affected outcome in patients with acute leukemia in complete remission who received T cell-depleted allogeneic hematopoietic stem cell transplantation from HLA identical siblings.	27623308
Acute leukemia	Stem Cell Exhaustion	In patients with acute leukemia, HTBI is more efficacious than STBI in eradicating minimal residual disease after HLA-matched T cell-depleted hematopoietic stem cell transplantation, thus affecting DFS.	27623308
Specialty Type - cancer	Stem Cell Exhaustion	Moreover, CST-Abl expression enabled 4T1 cells to persist innocuously in the mammary glands of mice, doing so by exhausting their supply of cancer stem cells.	27626309
Acanthamoeba, Sinusitis	Stem Cell Exhaustion	Successful Treatment of Sinusitis by Acanthamoeba in a Pediatric Patient After Allogeneic Stem Cell Transplantation.	27626919
Hematoma	Stem Cell Exhaustion	The early human fracture hematoma is characterized by maturation of granulocytes and migration of monocytes/macrophages and hematopoietic stem cells.	27629117
Disease, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Cytopenia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell disorders characterized by ineffective hematopoiesis, cytopenias and a risk of progression to acute myeloid leukemia (AML).	27629836
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft versus host disease (GVHD) is an important complication of peripheral blood stem cell transplantation.	27631185
Specialty Type - cancer	Stem Cell Exhaustion	Finally, we describe the TBX3-dependency of cancer stem cells that perpetuate themselves through an autocrine TBX3-ACTIVIN/NODAL signalling loop to sustain stemness.	27632063
Encephalitis, Opportunistic Infections	Stem Cell Exhaustion	An emerging opportunistic infection: fatal astrovirus (VA1/HMO-C) encephalitis in a pediatric stem cell transplant recipient.	27632248
Osteoporotic Fractures	Stem Cell Exhaustion	Real-Time H2 O2 Measurements in Bone Marrow Mesenchymal Stem Cells (MSCs) Show Increased Antioxidant Capacity in Cells From Osteoporotic Women.	27632788
Osteoporosis, Postmenopausal, Cocaine-Related Disorders	Stem Cell Exhaustion	It has also been associated with several age-related disorders, like postmenopausal osteoporosis of Mesenchymal stem cells (MSCs).	27632788
Malignant Neoplasms	Stem Cell Exhaustion	High-dose therapy and autologous stem cell transplantation in patients with POEMS syndrome: a retrospective study of the Plasma Cell Disorder sub-committee of the Chronic Malignancy Working Party of the European Society for Blood & Marrow Transplantation.	27634201
Engraftment syndrome	Stem Cell Exhaustion	Engraftment was seen in 97% patients and engraftment syndrome was documented in 23% of autologous stem cell transplantation recipients.	27634201
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	This analysis reports on 72 patients with relapsed or refractory non-Hodgkin lymphoma who were treated with R-DHAP salvage chemotherapy regimen followed by high-dose chemotherapy and stem cell transplantation.	27635469
Stargardts disease", methyldopa	Stem Cell Exhaustion	This paper describes some of the recent advances in the use of human stem cells, particularly those made in the area of ophthalmology, and more specifically, in Stargardt's disease and age-related macular degeneration (AMD).	27637197
Disease, Retinal Pigments	Stem Cell Exhaustion	We also present promising studies with induced pluripotent stem cells (iPS), aimed at obtaining retinal pigmented epithelium and light-sensitive retinal rods in the aforementioned ocular diseases, with encouraging preclinical and clinical results.	27637197
Neoplasms	Stem Cell Exhaustion	From a medical point of view, we must not forget that the transplanted retinal epithelium cells may cause tumours, since they have been obtained from Embryonic Stem cells, and may trigger immune rejection problems since they are heterologous.	27637197
Globoid cell leukodystrophy	Stem Cell Exhaustion	Hematopoietic Stem cell transplantation and lentiviral vector-based gene therapy for Krabbe's disease: Present convictions and future prospects.	27638600
Central Nervous System, Globoid cell leukodystrophy	Stem Cell Exhaustion	Currently, presymtomatic hematopoietic stem and progenitor cell transplantation (HSPCT) is the only therapeutic modality that alleviates Krabbe's disease (KD)-induced central nervous system damage.	27638600
Malignant neoplasm of kidney, Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Reduced expression of CXCR4, a novel renal cancer stem cell marker, is associated with high-grade renal cell carcinoma.	27638770
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells (CSCs) represent a population with tumour-initiating, self-renewal, and differentiation potential.	27638770
SLC25A20 gene	Stem Cell Exhaustion	In univariate analysis, those positive for tissue factor, ICAM-1, stem cells, and adipocytes (P16-set) antigens associated with CAC in the PE group.	27639028
Hepatobiliary System, Bile duct structure	Stem Cell Exhaustion	Biliary-committed progenitor cells (small mouse cholangiocytes; SMCCs) from small bile ducts are more resistant to hepatobiliary injury than large mouse cholangiocytes (LGCCs) from large bile ducts.	27639079
Injury of liver	Stem Cell Exhaustion	The definitive endoderm marker and the positive regulator of biliary development, FoxA2, mediates the therapeutic effect of biliary-committed progenitor cells during cholestatic liver injury.	27639079
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic stem cell transplantation is the only curative option for patients with acute myeloid leukemia (AML) experiencing relapse.	27639553
NES gene	Stem Cell Exhaustion	The collective expression of stem cell-related genes SOX2, OCT4, LGR5, TP63 (p63), as well as neural crest marker genes PSIP1 (p75(NTR)), PAX3, SOX9, AP2B1 (AP-2b), and NES, generated a phenotypic footprint of endothelial NCDPs.	27639969
Dystrophy	Stem Cell Exhaustion	Existence of Neural Crest-Derived Progenitor Cells in Normal and Fuchs Endothelial Dystrophy Corneal Endothelium.	27639969
Nephroblastoma	Stem Cell Exhaustion	Re-implantation of cryopreserved ovarian cortex resulting in restoration of ovarian function, natural conception and successful pregnancy after haematopoietic stem cell transplantation for Wilms tumour.	27639996
Nephroblastoma	Stem Cell Exhaustion	A 32-year-old woman had ovarian cortex cryopreserved 10 years previously before commencing high-dose chemotherapy and undergoing a haematopoietic stem cell transplant for recurrent adult Wilms tumour, which resulted in POI.	27639996
Multiple Myeloma	Stem Cell Exhaustion	Comparison of two dose levels of cyclophosphamide for successful stem cell mobilization in myeloma patients.	27640002
Multiple Myeloma	Stem Cell Exhaustion	Even in the era of proteasome inhibitors and immunomodulatory drugs, the autologous stem cell transplantation after high-dose melphalan continues to represent a standard approach for myeloma patients in first-line therapy.	27640002
Multiple Myeloma	Stem Cell Exhaustion	We retrospectively analyzed the impact of "intermediate-dose" (ID-CY, 2.5 g/m2) versus "high-dose" (HD-CY, 4 g/m2) cyclophosphamide in 101 (48 vs. 53) consecutively evaluable myeloma patients (median age 59 years, range 32-72 years) who underwent stem cell mobilization after induction chemotherapy.	27640002
Toxic effect, Multiple Myeloma	Stem Cell Exhaustion	ID-CY is safe and highly effective for stem cell mobilization in patients with newly diagnosed myeloma and associated with a reduced toxicity compared to HD-CY.	27640002
Neoplasms	Stem Cell Exhaustion	Mesenchymal stromal cells (MSCs) are multipotent progenitor cells and there is much interest in how MSCs contribute to the regulation of the tumor microenvironment.	27641212
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Expression of migration-related genes in fast-migrating glioma cells is not only regulated in a progression-dependent manner, but these cells are also characterized by specific stem cell-like features.	27641619
Aplastic Anemia	Stem Cell Exhaustion	Effect of Recipient Age and Stem Cell Source on the Association between Donor Telomere Length and Survival after Allogeneic Unrelated Hematopoietic Cell Transplantation for Severe Aplastic Anemia.	27641680
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This study evaluated the safety and efficacy of thiotepa-based regimens before allogeneic stem cell transplantation in 310 adult patients with AML.	27643865
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	In the CORAL study, 255 chemosensitive relapses with diffuse large B-cell lymphoma (DLBCL) were consolidated with autologous stem cell transplantation (ASCT), and 75 of them relapsed thereafter.	27643872
Degenerative polyarthritis, Cartilage	Stem Cell Exhaustion	While autologous chondrocyte or mesenchymal stem cell (MSC) implantation can be applied to repair cartilage defects in young patients, no appropriate long-lasting treatment alternative is available for elderly patients with osteoarthritis (OA).	27644879
Degenerative polyarthritis	Stem Cell Exhaustion	We therefore analyzed chondrocyte- and stem cell-related markers, cell growth rate, and multipotency in OA chondrocytes (OACs) and bone marrow-derived MSCs, along with normal articular chondrocytes (ACs) as a control.	27644879
Degenerative polyarthritis	Stem Cell Exhaustion	Multipotent progenitor cells are reported to present in adult human articular cartilage, with a preponderance in OA cartilage.	27644879
Degenerative polyarthritis	Stem Cell Exhaustion	We conclude that chondrogenic capacity is not significantly affected by OA, and OACs could be a potential source of multipotent progenitor cells for cartilage tissue engineering.	27644879
Hepatitis C, Malignant Neoplasms, Communicable Diseases	Stem Cell Exhaustion	Exclusion criteria included previous exposure to HDAC inhibitors; previous allogeneic stem-cell transplantation; previous autologous stem-cell transplantation within 12 weeks of baseline; active systemic infection; malignancy within the last 5 years; known or suspected HIV, hepatitis B, or hepatitis C infection; a QTc Fridericia of more than 480 ms; and substantial cardiovascular, gastrointestinal, psychiatric, or other medical disorders.	27646843
mecarzole, Childhood Breast Carcinoma	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation (auto-HSCT) remains an experimental therapy for metastatic breast cancer (MBC) and there is no established protocol for cluster of differentiation 34+ (CD34+ ) hematopoietic progenitor cell (HPC) mobilization with historic studies using growth factors with or without chemotherapy.	27649817
Childhood Breast Carcinoma	Stem Cell Exhaustion	Feasibility and kinetics of CD34+ hematopoietic progenitor cell mobilization in response to a single administration of docetaxel chemotherapy and pegfilgrastim in a contemporary cohort of patients with metastatic breast cancer.	27649817
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Prognostic pre-transplant factors in myelodysplastic syndromes primarily treated by high dose allogeneic hematopoietic stem cell transplantation: a retrospective study of the MDS subcommittee of the CMWP of the EBMT.	27650829
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Many pre-transplant factors are known to influence the outcome of allogeneic stem cell transplantation (SCT) treatment in myelodysplastic syndromes (MDS).	27650829
Gastrointestinal mucositis	Stem Cell Exhaustion	Use of sodium hyaluronate and synthetic amino acid precursors of collagen for the symptomatic treatment of mucositis in patients undergoing haematopoietic stem cell transplants.	27655517
Gastrointestinal mucositis	Stem Cell Exhaustion	Oral mucositis (OM) may occur in up to 100% of patients undergoing condition regimen to hematopoietic stem cell transplant (HSCT).	27655517
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Patients treated with allogeneic hematopoietic stem cell transplantation (HSCT) may experience oral complications associated with chronic graft-versus-host disease (cGVHD).	27655559
Non-Malignant	Stem Cell Exhaustion	Hematopoietic stem cell transplantation is an established treatment for many malignant and non-malignant haematological disorders.	27658169
Hodgkin Disease	Stem Cell Exhaustion	In the current case report, we describe the first haploidentical stem cell transplantation, used for the first time in Romania, the case of a 33 year-old young woman diagnosed with Hodgkin's lymphoma that has underwent a haploSCT after she relapsed from several chemotherapy regimens, as well as after an autologous stem cell transplantation.	27658169
Infection	Stem Cell Exhaustion	Absent T-cell immunity resulting in life-threatening infections provides a clear rationale for hematopoetic stem cell transplantation (HSCT) in patients with severe combined immunodeficiency (SCID).	27658761
Primary Myelofibrosis	Stem Cell Exhaustion	Splenic pooling and loss of VCAM-1 causes an engraftment defect in patients with myelofibrosis after allogeneic hematopoietic stem cell transplantation.	27662011
Primary Myelofibrosis	Stem Cell Exhaustion	Improved engraftment in myelofibrosis might be achieved by approaches that reduce spleen size and cleavage of VCAM-1 in these patients prior to hematopoietic stem cell transplantation.	27662011
Primary Myelofibrosis	Stem Cell Exhaustion	In conclusion, our data suggest that reduced engraftment and graft failure in myelofibrosis patients is caused by an early pooling of CD34+ hematopoietic stem cells in the spleen and a bone marrow homing defect caused by the loss of VCAM-1.	27662011
Graft-vs-Host Disease	Stem Cell Exhaustion	A prospective randomized trial comparing cyclosporine/methotrexate and tacrolimus/sirolimus as graft-versus-host disease prophylaxis after allogeneic hematopoietic stem cell transplantation.	27662016
Graft-vs-Host Disease	Stem Cell Exhaustion	Improvement of graft-versus-host disease prophylaxis remains an important goal in allogeneic hematopoietic stem cell transplantation.	27662016
Graft-vs-Host Disease	Stem Cell Exhaustion	Based on reports of possibly preferential properties of sirolimus, we compared the standard regimen of cyclosporine and methotrexate (n=106) with a combination of tacrolimus and sirolimus (n=103) as graft-versus-host disease prophylaxis after allogeneic hematopoietic stem cell transplantation in a prospective, open, randomized trial.	27662016
Graft-vs-Host Disease, tacrolimus	Stem Cell Exhaustion	We conclude that tacrolimus/sirolimus remains a valid and safe alternative to cyclosporine/methotrexate as graft-versus-host disease prophylaxis after allogeneic hematopoietic stem cell transplantation, with comparable transplant-related outcomes.	27662016
melanoma	Stem Cell Exhaustion	In malignant melanoma (MM), the proteins SOX10, ABCB5 and CD271 are strongly expressed, and are associated with tumour-initiating potential and stem cell-like properties.	27663144
Liver carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Identification of Keratin 19-Positive Cancer Stem Cells Associating Human Hepatocellular Carcinoma Using 18F-Fluorodeoxyglucose Positron Emission Tomography.	27663597
Liver carcinoma, Specialty Type - cancer, Hollings Cancer Center	Stem Cell Exhaustion	Purpose: The current lack of tools for easy assessment of cancer stem cells (CSC) prevents the development of therapeutic strategies for hepatocellular carcinoma (HCC).	27663597
TP53 gene	Stem Cell Exhaustion	Homozygous inactivation of Keap1 or Trp53 promoted airway basal stem cell (ABSC) self-renewal, suggesting that mutations in these genes lead to expansion of mutant stem cell clones.	27663899
Central Nervous System Infection	Stem Cell Exhaustion	Central nervous system infection following allogeneic hematopoietic stem cell transplantation.	27664550
Infection	Stem Cell Exhaustion	Here, we described the clinical characteristics and outcomes of central nervous system (CNS) infections occurring after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in a single institution over the previous 6 years.	27664550
Ischemic cardiomyopathy	Stem Cell Exhaustion	The IMPACT-CABG trial: A multicenter, randomized clinical trial of CD133+ stem cell therapy during coronary artery bypass grafting for ischemic cardiomyopathy.	27665225
Cardiomyopathies	Stem Cell Exhaustion	The IMPACT-CABG trial is the first North American multicenter phase II randomized study of intramyocardial delivery of autologous CD133+ stem cells in patients with chronic ischemic cardiomyopathy undergoing coronary artery bypass grafting.	27665225
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Long-Lasting Protective Effect of Posaconazole Prophylaxis in Patients with Acute Myeloid Leukemia Receiving Allogeneic Hematopoietic Stem Cell Transplantation.	27667012
Leukemia, Myelocytic, Acute, Mycoses	Stem Cell Exhaustion	Patients with acute myeloid leukemia (AML) during induction chemotherapy and those who receive allogeneic hematopoietic stem cell transplantation (HSCT) are at higher risk of invasive fungal infections (IFI).	27667012
Aspects of mortality statistics	Stem Cell Exhaustion	Control of infectious mortality due to carbapenemase-producing Klebsiella pneumoniae in hematopoietic stem cell transplantation.	27668762
Cessation of life, Infection	Stem Cell Exhaustion	Carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) infections are an emerging cause of death after hematopoietic stem cell transplantation (HSCT).	27668762
leukemia	Stem Cell Exhaustion	Thiotepa-based conditioning for allogeneic stem cell transplantation in acute lymphoblastic leukemia-A survey from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.	27673280
Acute lymphocytic leukemia	Stem Cell Exhaustion	In this study, we analyzed a thiotepa-based conditioning regimen for allogeneic stem cell transplantation in adults with acute lymphoblastic leukemia, using the EBMT database.	27673280
Chronic graft-versus-host disease	Stem Cell Exhaustion	The proteome pattern cGvHD_MS14 allows early and accurate prediction of chronic GvHD after allogeneic stem cell transplantation.	27677743
Lymphoma	Stem Cell Exhaustion	Y90 -Ibritumomab tiuxetan (Y90 -IT) and high-dose melphalan as conditioning regimen before autologous stem cell transplantation for elderly patients with lymphoma in relapse or resistant to chemotherapy: a feasibility trial (SAKK 37/05).	27677906
Multiple Myeloma	Stem Cell Exhaustion	Prolonged survival with a longer duration of maintenance lenalidomide after autologous hematopoietic stem cell transplantation for multiple myeloma.	27680710
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Although lenalidomide maintenance therapy has demonstrated improved outcomes after autologous hematopoietic stem cell transplantation (auto-HCT) for patients with multiple myeloma (MM), the impact of the duration of this therapy is not clearly known.	27680710
Squamous cell carcinoma of esophagus, Esophageal Neoplasms	Stem Cell Exhaustion	Gli1, a potential regulator of esophageal cancer stem cell, is identified as an independent adverse prognostic factor in esophageal squamous cell carcinoma.	27680978
Neoplasms, Cancer Stem Cells	Stem Cell Exhaustion	The hedgehog (Hh) pathway is involved in cancer stem cell (CSC) maintenance in various tumors.	27680978
Extrapulmonary Small Cell Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Gene set enrichment analysis revealed that the Gli1-high-expressing ESCC patients' group was strongly enriched for gene expression signature of Hh signaling pathway, epithelial-mesenchymal transition, and cancer stem cell.	27680978
Extrapulmonary Small Cell Carcinoma	Stem Cell Exhaustion	Targeting Gli1, a potential diagnostic marker of ESCC stem cells, will have a profound therapeutic and prognostic value.	27680978
Acquired disease	Stem Cell Exhaustion	Genetic inborn along with acquired diseases arise due to the lesions in genome of multipotent hematopoietic stem cells.	27685529
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Absence of translocation t(9;22)(q34;q11) in blast transformed T-lymphocytes at diagnosis of CML evidences that this translocation may appear not only at the level of multipotent haemopoietic cell progenitors but also may have oligo lineage myeloid origin.	27685529
Malignant neoplasm of breast, Childhood Breast Carcinoma	Stem Cell Exhaustion	Low expression of galectin-3 is associated with poor survival in node-positive breast cancers and mesenchymal phenotype in breast cancer stem cells.	27687248
Neoplasms, Specialty Type - cancer, Transcription Initiation	Stem Cell Exhaustion	Galectin-3 (Gal3) plays diverse roles in cancer initiation, progression, and drug resistance depending on tumor type characteristics that are also associated with cancer stem cells (CSCs).	27687248
Lymphoma, Non-Hodgkin, Familial, Mature B-Lymphocyte, Natural Killer Cells, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	A preventive effect of early human cytomegalovirus (HCMV) replication was evaluated in 136 non-Hodgkin lymphoma (NHL) patients with mature B-cell NHLs (n = 94), and mature T- and NK-cell NHLs (n = 42) after allogeneic stem cell transplantation (alloSCT).	27687578
Myelodysplastic-Myeloproliferative Diseases	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplant in adult patients with myelodysplastic syndrome/myeloproliferative neoplasm (MDS/MPN) overlap syndromes.	27687869
Myelodysplastic-Myeloproliferative Diseases, Myeloid neoplasm	Stem Cell Exhaustion	MDS/MPN (myelodysplastic syndrome/myeloproliferative neoplasm) overlap syndromes are myeloid malignancies for which allogeneic hematopoietic stem cell transplant (allo-HSCT) is potentially curative.	27687869
Hypoxia	Stem Cell Exhaustion	Furthermore, physiological O2 levels increased migration (P < 0.05) compared with room air and hypoxia, and treatment with mesenchymal stem cell-conditioned media rescued CSC migration under hypoxia to levels comparable to physiological O2 migration (2-fold, P < 0.05 relative to CSC media control).	27694215
Heart failure	Stem Cell Exhaustion	Cardiac stem cells (CSCs) are being evaluated for their efficacy in the treatment of heart failure.	27694215
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Although the role of cancer stem cells (CSCs), a subset of tumor cells with the self-renewal and differentiation capabilities, in therapeutic resistance is beginning to be better understood, the significance of epigenetic regulatory mechanisms responsible for integrating the stemness with drug resistance remain poorly understood.	27694900
FAP protein, human	Stem Cell Exhaustion	To improve this situation, clinical application of pluripotent stem cell-derived MLs may be useful as an approach for FAP therapy.	27695122
leukemia	Stem Cell Exhaustion	In addition, patients receiving hematopoietic stem cell transplants for leukemia may do better if their donor has more activating KIR genes (i.e., KIR haplotype-B).	27695964
Neoplasms	Stem Cell Exhaustion	Recently aldehyde dehydrogenase 1A1 (ALDH1A1) was proposed as a stem cell marker for malignant PT but its expression has not been studied in benign and borderline tumours.	27696244
Histoplasmosis, Multiple Myeloma	Stem Cell Exhaustion	Gastrointestinal histoplasmosis in a patient after autologous stem cell transplant for multiple myeloma.	27696648
Post-transplant lymphoproliferative disorder, Lymphoproliferative Disorders	Stem Cell Exhaustion	Notably, hematopoietic stem cell transplantation (HSCT) recipients with a detectable blood EBV viral load (BEBVL) are considered at higher risk of post-transplant lymphoproliferative diseases (PTLD).	27696681
Primary Myelofibrosis, Thrombus, Hemorrhagic, Polycythemia Vera, Acute leukemia	Stem Cell Exhaustion	Polycythemia vera (PV) is an acquired clonal hematopoietic stem cell disorder characterized by an overproduction of red blood cells, white blood cells, and platelets; thrombotic and hemorrhagic complications; and an increased risk of transformation to myelofibrosis and acute leukemia.	27697978
Specialty Type - cancer	Stem Cell Exhaustion	The gradual accumulation of genetic mutations in human adult stem cells (ASCs) during life is associated with various age-related diseases, including cancer.	27698416
Lymphoma	Stem Cell Exhaustion	Outpatient administration of BEAM conditioning prior to autologous stem cell transplantation for lymphoma is safe, feasible, and cost-effective.	27699999
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	High-dose BEAM chemotherapy (BCNU, etoposide, Ara-C, and melphalan) followed by autologous hematopoietic stem cell transplantation is frequently used as consolidative therapy for patients with recurrent or refractory Hodgkin or non-Hodgkin lymphoma.	27699999
Tissue damage	Stem Cell Exhaustion	Early hematopoietic stem cell transplantation is advisable before tissue damage is irreversible.	27701760
Epithelial, Inflammation, Photophobia, Usual Severity Pain	Stem Cell Exhaustion	Patients with limbal stem cell deficiency (LSCD) often experience pain and photophobia due to recurrent epithelial defects and chronic inflammation of the cornea.	27702552
Malignant neoplasm of ovary	Stem Cell Exhaustion	Novel population of small tumour-initiating stem cells in the ovaries of women with borderline ovarian cancer.	27703207
Malignant neoplasm of ovary	Stem Cell Exhaustion	Here, we show that a comparable population of small stem cells can be found in the ovarian tissue of women with borderline ovarian cancer, which, in contrast to small stem cells in "healthy" ovaries, formed spontaneous tumour-like structures and expressed some markers related to pluripotency and germinal lineage.	27703207
Malignant neoplasm of ovary, Specialty Type - cancer	Stem Cell Exhaustion	The gene expression profile of these small putative cancer stem cells differed from similar cells sorted from "healthy" ovaries by 132 upregulated and 97 downregulated genes, including some important forkhead box and homeobox genes related to transcription regulation, developmental processes, embryogenesis, and ovarian cancer.	27703207
Specialty Type - cancer	Stem Cell Exhaustion	These putative cancer stem cells are suggested to be a novel population of ovarian tumour-initiating cells in humans.	27703207
Specialty Type - cancer, Carcinoma, Transitional Cell	Stem Cell Exhaustion	Risk stratification by epithelial-mesenchymal transition and cancer stem cell-regulated genes, such as Snail and Bmi-1, might be useful prognostic markers for upper tract urothelial carcinoma.	27704680
Neoplasms	Stem Cell Exhaustion	Spontaneous tumour regression after high-dose therapy and autologous stem cell transplantation is associated with the aplastic anaemia-like syndrome and the presence of polyclonal autoantibodies against carbonic anhydrase I (CA I).	27704726
Bone necrosis	Stem Cell Exhaustion	The critical roles of IGFBP3 in regulating the osteogenic and adipogenic differentiation of bone marrow mesenchymal stem cells strongly indicate its potential effects on the pathogenesis of osteonecrosis of the femoral head (ONFH).	27704894
Adult Glioblastoma, Specialty Type - cancer	Stem Cell Exhaustion	Analysis of angiogenesis related factors in glioblastoma, peritumoral tissue and their derived cancer stem cells.	27705944
Specialty Type - cancer, Glioblastoma	Stem Cell Exhaustion	In this study, we evaluated by immunohistochemistry, and/or Western blotting and/or quantitative real time-PCR the expression of HIF1a, HIF2a, VEGF, VEGFR1 and VEGFR2 in surgical glioblastoma multiforme (GBM) and peritumoral tissue samples obtained from 50 patients as well as in cancer stem cells (CSCs) isolated from GBM (GCSCs) and peritumoral tissue (PCSCs) of 5 patients.	27705944
Columnar Metaplasia	Stem Cell Exhaustion	Most interestingly, it is a clinical example showcasing the origin of columnar metaplasia from stem cells located within the esophageal epithelium.	27708180
Neoplasms, Lymphoma	Stem Cell Exhaustion	Next-generation sequencing-based detection of circulating tumour DNA After allogeneic stem cell transplantation for lymphoma.	27711974
Lymphoma	Stem Cell Exhaustion	We evaluated whether the presence of ctDNA was associated with outcome after allogeneic haematopoietic stem cell transplantation (HSCT) in lymphoma patients.	27711974
Toxic effect	Stem Cell Exhaustion	A Comprehensive Assessment of Toxicities in Patients with Central Nervous System Lymphoma Undergoing Autologous Stem Cell Transplantation Using Thiotepa, Busulfan, and Cyclophosphamide Conditioning.	27713090
Primary central nervous system lymphoma, Toxic effect	Stem Cell Exhaustion	High-dose therapy and autologous stem cell transplantation (ASCT) with thiotepa, busulfan, and cyclophosphamide (TBC) conditioning has emerged as an effective postinduction treatment strategy for patients with primary central nervous system lymphoma (PCNSL) or secondary central nervous system lymphoma (SCNSL), but it is associated with considerable toxicity and transplantation-related mortality (TRM) in the modern era.	27713090
Specialty Type - cancer	Stem Cell Exhaustion	Variation in cancer risk among somatic tissues has been attributed to variations in the underlying rate of stem cell division.	27716309
Specialty Type - cancer	Stem Cell Exhaustion	For a given tissue type, variable cancer risk between individuals is thought to be influenced by extrinsic factors which modulate this rate of stem cell division.	27716309
Specialty Type - cancer	Stem Cell Exhaustion	To date, no molecular mitotic clock has been developed to approximate the number of stem cell divisions in a tissue of an individual and which is correlated with cancer risk.	27716309
Post-Traumatic Stress Disorder	Stem Cell Exhaustion	Cancer-and-treatment-specific distress and its impact on posttraumatic stress in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT).	27718504
Post-Traumatic Stress Disorder	Stem Cell Exhaustion	In this prospective multicenter study, we investigated cancer-and-treatment-specific distress (CTXD) and its impact on symptoms of posttraumatic stress disorder (PTSD) in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT).	27718504
Impaired cognition, "Alzheimers Disease	Stem Cell Exhaustion	Human Umbilical Cord Stem Cell Xenografts Improve Cognitive Decline and Reduce the Amyloid Burden in a Mouse Model of Alzheimer's Disease.	27719629
Neurodegenerative Disorders	Stem Cell Exhaustion	Over the past 20 years, stem cell technologies have become an increasingly attractive option to both study and potentially treat neurodegenerative diseases.	27719629
Up	Stem Cell Exhaustion	We aimed to explore the possible therapeutic potential of human umbilical cord mesenchymal stem cell xenografts in a transgenic (Tg) mouse model of AD.	27719629
Up	Stem Cell Exhaustion	APP/PS1 Tg AD model mice received human umbilical cord stem cells, directly injected into the carotid artery.	27719629
Up	Stem Cell Exhaustion	To test the efficacy of the umbilical cord stem cells in this AD model, behavioral tasks (sensorimotor and cognitive tests) and immunohistochemical quantitation of the pathology was performed.	27719629
Up, Cognitive	Stem Cell Exhaustion	Treatment of the APP/PS1 AD model mice, with human umbilical cord stem cells, produced a reduction of the amyloid beta burden in the cortex and the hippocampus which correlated with a reduction of the cognitive loss.	27719629
Up, Dental Plaque	Stem Cell Exhaustion	Human umbilical cord mesenchymal stem cells appear to reduce AD pathology in a transgenic mouse model as documented by a reduction of the amyloid plaque burden compared to controls.	27719629
Up	Stem Cell Exhaustion	Several investigators reported a beneficial effect of different types of stem or progenitor cells on the pathology and cognitive function in AD models.	27719629
Amyotrophic Lateral Sclerosis	Stem Cell Exhaustion	Intraspinal stem cell transplantation for amyotrophic lateral sclerosis: Ready for efficacy clinical trials?	27720637
Amyotrophic Lateral Sclerosis, Antilymphocyte Serum	Stem Cell Exhaustion	Intraspinal stem cell (SC) transplantation represents a new therapeutic approach for amyotrophic lateral sclerosis (ALS) clinical trials.	27720637
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic Stem Cell Transplantation for Patients Age >= 70 Years with Myelodysplastic Syndrome: A Retrospective Study of the MDS Subcommittee of the Chronic Malignancies Working Party of the EBMT.	27720995
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	In this retrospective analysis we evaluated the outcome of 313 patients aged >= 70 years in the registry of the European Group for Blood and Marrow Transplantation with myelodysplastic syndrome (MDS; n = 221) and secondary acute myeloid leukemia (n = 92) who underwent allogeneic hematopoietic stem cell transplantation (HSCT) from related (n = 79) or unrelated (n = 234) donors.	27720995
Steroid-Refractory Pneumonitis	Stem Cell Exhaustion	Jak1/2 inhibitor ruxolitinib is a promising agent for treating steroid-refractory GvHD after allogeneic hematopoietic stem cell transplantation (SCT) to produce quick and durable responses.	27721370
Kidney Diseases	Stem Cell Exhaustion	Hematopoietic Stem Cell Transplantation Nephropathy Associated with Chronic Graft-versus-Host Disease without Extrarenal Involvement.	27725545
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	A 30-year-old woman with myelodysplastic syndrome underwent allogeneic hematopoietic stem cell transplantation (HSCT) derived from her HLA-matched sister six years previously.	27725545
Cytomegalovirus Infections, Hematological Disease	Stem Cell Exhaustion	Cytomegalovirus infection in patients with haematological diseases and after autologous stem cell transplantation as consolidation: a single-centre study.	27730340
Myeloid, Myeloid Leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Accordingly, we addressed the applicability of human myeloid inhibitory C-lectin (hMICL) by flow cytometry as a specific leukemic myeloid stem cell marker for the diagnosis of AML in CD34+ and CD34- cases and evaluated the stability of hMICL during the course of the disease.	27734526
Muscular Dystrophy	Stem Cell Exhaustion	Small Fractions of Muscular Dystrophy Embryonic Stem Cells Yield Severe Cardiac and Skeletal Muscle Defects in Adult Mouse Chimeras.	27734557
Acute lymphocytic leukemia	Stem Cell Exhaustion	Hematopoietic stem cells can be separated from leukemic cells in a subgroup of adult acute lymphoblastic leukemia patients.	27734718
Acute lymphocytic leukemia	Stem Cell Exhaustion	In B-cell acute lymphoblastic leukemia (B-ALL) separation of normal hematopoietic stem cells (HSC) has so far been limited to a subgroup of patients.	27734718
Multiple Myeloma	Stem Cell Exhaustion	Upfront use of plerixafor and granulocyte-colony stimulating factor (GCSF) for stem cell mobilization in patients with multiple myeloma: efficacy and analysis of risk factors associated with poor stem cell collection efficiency.	27735212
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Plerixafor (P), an agent that selectively and reversibly binds to the chemokine receptor CXCR4, has been approved in combination with G-CSF (P + G-CSF) for stem cell (SC) mobilization in patients with multiple myeloma (MM).	27735212
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation in elderly patients with multiple myeloma: evaluation of its safety and efficacy.	27736269
Malignant tumor of colon	Stem Cell Exhaustion	CD24 is a membrane protein that acts as the ligand for P-selectin and has been defined as a stem cell marker of colonic cancer.	27738793
Specialty Type - cancer	Stem Cell Exhaustion	The role of cancer stem cells in the initiation and progression of cancer has become a well-studied area of emerging research, and stem cells with different surface markers have been identified in various types of cancer.	27738793
Chemotherapy-induced nausea and vomiting	Stem Cell Exhaustion	A randomized trial of olanzapine versus palonosetron versus infused ondansetron for the treatment of breakthrough chemotherapy-induced nausea and vomiting in patients undergoing hematopoietic stem cell transplantation.	27738796
Chemotherapy-induced nausea and vomiting, Chemotherapy-induced Nausea and Vomiting Questionnaire	Stem Cell Exhaustion	The primary aim of this study was to compare the effectiveness of olanzapine, palonosetron and ondansetron infusion (standard of care) for the treatment of breakthrough chemotherapy-induced nausea and vomiting (CINV) in patients undergoing hematopoietic stem cell transplantation (HSCT).	27738796
Endocrine Disruptors, Fibroid Tumor	Stem Cell Exhaustion	Developmental Exposure to Endocrine Disruptors Expands Murine Myometrial Stem Cell Compartment as a Prerequisite to Leiomyoma Tumorigenesis.	27739139
LMNA wt Allele	Stem Cell Exhaustion	A High Throughput Phenotypic Screening reveals compounds that counteract premature osteogenic differentiation of HGPS iPS-derived mesenchymal stem cells.	27739443
LMNA wt Allele	Stem Cell Exhaustion	Thanks to the pluripotency and self-renewal properties of induced pluripotent stem cells (iPSC), HGPS iPSC-based modeling opens up the possibility of access to different relevant cell types for pharmacological approaches.	27739443
LMNA wt Allele	Stem Cell Exhaustion	In this study, 2800 small molecules were explored using high-throughput screening, looking for compounds that could potentially reduce the alkaline phosphatase activity of HGPS mesenchymal stem cells (MSCs) committed into osteogenic differentiation.	27739443
Prostate carcinoma	Stem Cell Exhaustion	In addition, we investigated a non-dioxin-like PCB153-induced cell invasion and related markers in normal prostate stem cells (WPE-stem) and in three different prostate cancer cell lines (PC3, DU145 and 22RV1) at exposure levels relevant to humans.	27742691
Prostate carcinoma	Stem Cell Exhaustion	Cell invasion and related markers, including MMP9, MMP2, Slug and Snail, were significantly increased in human prostate cancer cells as well as in prostate stem cells after exposure to PCB153.	27742691
Gastrointestinal infection	Stem Cell Exhaustion	Gastrointestinal infections by cytomegalovirus (CMV) and adenovirus may complicate hematopoietic stem cell transplantation (HSCT).	27744342
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We have retrospectively compared survivals between acute myeloid leukemia (AML)/myelodysplastic syndrome (MDS) patients who received either a clofarabine/busulfan (CloB2A2) or a fludarabine/busulfan (FB2A2) RIC regimen for allogeneic stem cell transplantation.	27748046
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells (CSCs) have self-renewal and pluripotency capabilities and contribute to cancer progression and chemoresistance.	27748881
Primary central nervous system lymphoma	Stem Cell Exhaustion	Promising treatment results with blood brain barrier disruption (BBBD) based immunochemotherapy combined with autologous stem cell transplantation (ASCT) in patients with primary central nervous system lymphoma (PCNSL).	27752883
Graft-vs-Host Disease	Stem Cell Exhaustion	Severe graft-versus-host disease is a major barrier for non-T-cell-depleted haploidentical stem cell transplantation.	27758821
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	AML-LTC are established by isolating mononuclear cells from peripheral blood samples of AML patients followed by selection of CD34+ progenitor cells.	27761818
Toxic effect	Stem Cell Exhaustion	Overall, combination fludarabine-melphalan with low-dose TBI after haplocord stem cell transplant assures good engraftment and leads to acceptable toxicity and disease control in the setting of high risk, heavily pretreated patients.	27764032
Tachycardia, Ventricular	Stem Cell Exhaustion	Patient-Specific Human Induced Pluripotent Stem Cell Model Assessed with Electrical Pacing Validates S107 as a Potential Therapeutic Agent for Catecholaminergic Polymorphic Ventricular Tachycardia.	27764147
Hematologic Neoplasms	Stem Cell Exhaustion	Clinical sample sets of throat swab, EDTA-blood and blood sera from 50 patients with severe haematological malignancies, including haematopoietic stem cell transfer (HSCT), and samples from 30 healthy individuals were then analysed.	27765533
Hypovolemic Shock	Stem Cell Exhaustion	Pediatric apheresis for peripheral blood stem cell transplantation should be carried out with due concern for low corporeal blood volume and vulnerability to hypocalcemia-related complications, hypovolemic shock, and hypervolemic cardiac overload.	27765663
Malignant neoplasm of lung, Pneumonia	Stem Cell Exhaustion	The aims of this study were to describe the computed tomographic features of organizing pneumonia (OP) in an oncologic patient population and to also identify features associated with lung cancer and patients undergoing hematopoietic stem cell transplant (HSCT).	27768620
pM category, Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	Combination of Cancer Stem Cell Markers CD44 and CD24 Is Superior to ALDH1 as a Prognostic Indicator in Breast Cancer Patients with Distant Metastases.	27768764
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	The combination of CD44 and CD24, or aldehyde dehydrogenase 1 (ALDH1) alone, is a widely used cancer stem cell marker in breast cancer.	27768764
Specialty Type - cancer	Stem Cell Exhaustion	Immunohistochemical evaluation using cancer stem cell markers is clearly less common clinically than in basic experiments and how the expressions of these markers relate to patient outcomes remains controversial.	27768764
Retinal Pigments	Stem Cell Exhaustion	Several cell types in culture generate TA4 from ambient thyroxine, including fibrocytes, HELA cells, human Muller stem cells, and retinal pigmented epithelial cells.	27768856
Chronic graft-versus-host disease	Stem Cell Exhaustion	We applied TCR-a-NGS to samples from two patients with chronic GVHD who received comparable doses of stem cell donor derived expanded Treg .	27774628
Multiple Myeloma	Stem Cell Exhaustion	Peripheral blood stem cell mobilization in multiple myeloma comparison of two consecutive regimens in a limited resources country.	27775695
Toxic effect	Stem Cell Exhaustion	This study compared retrospectively the effectiveness, toxicity and hematopoietic recovery after autologous peripheral blood stem cell transplantation (ASCT) of two consecutive peripheral blood stem cell mobilization regimens in newly diagnosed MM patients.	27775695
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients with Myelodysplastic Syndrome Harboring Trisomy 8.	27777139
PAFAH1B1 wt Allele	Stem Cell Exhaustion	However, the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) in adult patients with MDS harboring +8 remains unclear.	27777139
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Outcome of FLT3-ITD-positive acute myeloid leukemia: impact of allogeneic stem cell transplantation and tyrosine kinase inhibitor treatment.	27778197
FLT3 Internal Tandem Duplication	Stem Cell Exhaustion	In particular, FLT3 internal tandem duplications (FLT3-ITD) are characterized by an unfavorable prognosis and allogeneic stem cell transplantation (allogeneic SCT) in first complete remission is recommended.	27778197
Hypertension, CTCAE	Stem Cell Exhaustion	This randomized study evaluates the effects of lercanidipine - as well as its antihypertensive efficacy - on the number of circulating endothelial progenitor cells (EPCs) in elderly patients with hypertension.	27779456
Neoplasms, Specialty Type - cancer, Childhood Breast Carcinoma, Secondary Neoplasm	Stem Cell Exhaustion	Cancer stem cells (CSCs) have been suggested to serve an important role in tumor recurrence and metastasis in breast cancer.	27779682
Colorectal Carcinoma	Stem Cell Exhaustion	Effect of colorectal cancer on the number of normal stem cells circulating in peripheral blood.	27779706
Inflammation, Traumatic AND/OR non-traumatic injury	Stem Cell Exhaustion	Bone marrow (BM) residing stem cells are mobilized from their BM niches into peripheral blood (PB) in several pathological situations including tissue organ injury and systemic inflammation.	27779706
Pancreatic carcinoma	Stem Cell Exhaustion	We recently reported that the number of BM-derived stem cells (SCs) increases in patients with pancreatic and stomach cancer.	27779706
Negative Regulation of Cell Cycle, Stem cells	Stem Cell Exhaustion	Overexpression of miRNA148a in ATC-CSCs induced cell cycle arrest and loss of stem cell characteristics.	27779717
Neoplasms	Stem Cell Exhaustion	Overexpression of miRNA-148a and knockdown of INO80 acted synergistically to decrease the expression of stem cell marker genes as well as to attenuate stem cell-specific properties including the ability to form tumors.	27779717
Malignant neoplasm of thyroid	Stem Cell Exhaustion	miR-148a inhibits self-renewal of thyroid cancer stem cells via repressing INO80 expression.	27779717
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells (CSCs) are proposed to be responsible for high recurrence rate in ATC.	27779717
Degenerative polyarthritis	Stem Cell Exhaustion	Fibulin 3 regulates differentiation of adult progenitor cells, and its aging-related decline is an early event in the pathogenesis of OA.	27780308
Arteriovenous fistula, Thrombosis	Stem Cell Exhaustion	Circulating Progenitor Cells Affect Thrombosis of Dialysis Arteriovenous Fistulas.	27784005
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) are mobilized into circulation under various pathophysiological conditions, and are thought to play an important role in tissue repair in chronic obstructive lung disease (COPD).	27784320
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Therefore, Sirt1 and EPC-associated mRNAs were measured in blood samples from patients with COPD and from cultured CD34+ progenitor cells to examine whether these genes are associated with COPD development.	27784320
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Outcome differences between children and adolescents and young adults with non-Hodgkin lymphoma following stem cell transplantation.	27787746
Leukemia, Myelocytic, Acute, Acute lymphocytic leukemia	Stem Cell Exhaustion	Several studies of patients with acute lymphoblastic leukemia and acute myeloid leukemia who received stem cell transplantation (SCT) have reported that adolescents and young adults (AYAs) experience higher transplant-related mortality than that in younger children.	27787746
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	We analyzed 918 patients aged 30 years and younger who received their first stem cell transplantation for NHL.	27787746
Malignant tumor of colon	Stem Cell Exhaustion	Identification of High-Risk Aberrant Crypt Foci and Mucin-Depleted Foci in the Human Colon With Study of Colon Cancer Stem Cell Markers.	27789195
Specialty Type - cancer	Stem Cell Exhaustion	Detailed topographic analyses, with immunohistochemical staining for b-catenin and cancer stem cell (CSC) markers (CD44, CD24, and CD166) were performed.	27789195
Mucopolysaccharidosis II	Stem Cell Exhaustion	Generation of Mucopolysaccharidosis type II (MPS II) human induced pluripotent stem cell (iPSC) line from a 7-year-old male with pathogenic IDS mutation.	27789394
Mucopolysaccharidosis II	Stem Cell Exhaustion	Generation of Mucopolysaccharidosis type II (MPS II) human induced pluripotent stem cell (iPSC) line from a 3-year-old male with pathogenic IDS mutation.	27789398
Mucopolysaccharidosis II	Stem Cell Exhaustion	Generation of Mucopolysaccharidosis type II (MPS II) human induced pluripotent stem cell (iPSC) line from a 1-year-old male with pathogenic IDS mutation.	27789399
Spastic Paraplegia, Hereditary, HSP90B2P wt Allele	Stem Cell Exhaustion	Establishment of SPAST mutant induced pluripotent stem cells (iPSCs) from a hereditary spastic paraplegia (HSP) patient.	27789400
Mucopolysaccharidosis II	Stem Cell Exhaustion	Generation of human induced pluripotent stem cell (iPSC) line from an unaffected female carrier of Mucopolysaccharidosis type II (MPS II) disorder.	27789401
Autistic Disorder, KLEEFSTRA SYNDROME 1, Kaposi Sarcoma	Stem Cell Exhaustion	Establishment of EHMT1 mutant induced pluripotent stem cell (iPSC) line from a 11-year-old Kleefstra syndrome (KS) patient with autism and normal intellectual performance.	27789404
Up, "Alzheimers Disease	Stem Cell Exhaustion	Human lymphoblast cells from a female patient diagnosed with Alzheimer's disease (AD) possessing the missense mutation TREM2 p.R47H were used to generate integration-free induced pluripotent stem cells (iPSCs) employing episomal plasmids expressing OCT4, SOX2, NANOG, LIN28, c-MYC and L-MYC.	27789408
Pick Disease of the Brain	Stem Cell Exhaustion	Induced pluripotent stem cells (iPSCs) derived from a symptomatic carrier of a S305I mutation in the microtubule-associated protein tau (MAPT)-gene causing frontotemporal dementia.	27789411
Ischemic cardiomyopathy	Stem Cell Exhaustion	An exploratory randomized control study of combination cytokine and adult autologous bone marrow progenitor cell administration in patients with ischaemic cardiomyopathy: the REGENERATE-IHD clinical trial.	27790824
Infection, Specialty Type - cancer	Stem Cell Exhaustion	Participants completed a 402-item questionnaire regarding the use of CAM, medical complications, specialist referrals, medications and therapies, infections, vaccinations, cancer screening, lifestyle, and occupational issues and relationship status following stem cell transplantation.	27790858
Sepsis	Stem Cell Exhaustion	Diagnostic value of sepsis biomarkers in hematopoietic stem cell transplant recipients in a condition of high prevalence of gram-negative pathogens.	27793578
Febrile Neutropenia, Communicable Diseases	Stem Cell Exhaustion	A decision about the need for antimicrobial therapy in a patient with febrile neutropenia after hematopoietic stem cell transplantation (HSCT) is often complicated because of the low frequency of culture isolation and reduced clinical manifestation of infection.	27793578
ACVR1 wt Allele	Stem Cell Exhaustion	Contrary to a previous study, here we show that FOP fibroblasts showed an increased efficiency of induced pluripotent stem cell (iPSC) generation.	27794120
Infection	Stem Cell Exhaustion	We analyzed the incidence, clinical characteristics, prognostic factors, and outcome of central nervous system (CNS) infections in consecutive patients with receiving umbilical cord blood transplantation (UCBT) (n = 343) or HLA-matched sibling donor stem cell transplantation (MST) (n = 366).	27794456
Infection	Stem Cell Exhaustion	In conclusion, our study showed that CNS infections are a significant clinical problem after stem cell transplantation associated with poor survival.	27794456
Parkinson Disease	Stem Cell Exhaustion	The Transcriptional Changes of trim Genes Associated with Parkinson's Disease on a Model of Human Induced Pluripotent Stem Cells.	27796756
Neurodegenerative Disorders	Stem Cell Exhaustion	Over the last few years, in vitro models, based on patient-derived induced pluripotent stem cells (iPSCs), have received considerable attention for modeling different neurodegenerative disorders.	27796756
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Imatinib Mesylate Versus Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Chronic Myelogenous Leukemia.	27797264
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	To compare the relative merits of imatinib and allogeneic hematopoietic stem cell transplantation (allo-HSCT) for chronic myelogenous leukemia (CML).	27797264
CARCINOMA OF VULVA, Specialty Type - cancer	Stem Cell Exhaustion	Immunological and Clinical Impact of Cancer Stem Cells in Vulvar Cancer: Role of CD133/CD24/ABCG2-Expressing Cells.	27798870
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells (CSCs) are tumour-initiating cells with self-renewal properties and chemo/radio-resistance.	27798870
Leukemia, Myelocytic, Acute, NPM1 wt Allele	Stem Cell Exhaustion	Pre-transplant Quantitative Determination of NPM1 Mutation Significantly Predicts Outcome of AIlogeneic Hematopoietic Stem Cell Transplantation in Patients with Normal Karyotype AML in Complete Remission.	27798920
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Minimal residual disease (MRD) in patients with acute myeloid leukemia (AML) before allogeneic hematopoietic stem cell transplantation (alloHSCT) can influence the results of therapy.	27798920
Colorectal Carcinoma	Stem Cell Exhaustion	Evaluation of circulating cellular DCLK1 protein, as the most promising colorectal cancer stem cell marker, using immunoassay based methods.	27802206
Colorectal Carcinoma	Stem Cell Exhaustion	DCLK1, as the most potential colorectal cancer stem cell (CSC) marker has been the core of many recent investigations.	27802206
Ataxia, Spinocerebellar	Stem Cell Exhaustion	Fusion of Human Fetal Mesenchymal Stem Cells with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice.	27802273
ovarian neoplasm	Stem Cell Exhaustion	Here, we demonstrate that EGFL6, a stem cell regulatory factor expressed in ovarian tumor cells and vasculature, regulates ALDH+ ovarian CSC.	27803106
Encephalitis, Hematologic Neoplasms, Pregnancy Complications, Infectious	Stem Cell Exhaustion	Toxoplasmic encephalitis is a rare infectious complication in patients with hematological malignancy except for allogeneic hematopoietic stem cell transplantation (HSCT).	27803415
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Leptin Level in Patients with Type 2 Diabetes Mellitus after Fetal Pancreatic Stem Cell Transplant.	27805510
Pancreas Transplantation, Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	We aimed to determine leptin level in patients with type 2 diabetes mellitus after fetal pancreatic stem cell transplant.	27805510
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	In patients with type 2 diabetes mellitus, fetal pancreatic stem cell transplant led to a significant increase in leptin levels, from 11.01 ng/mL to 16.29 ng/mL, after 3 months (P < .05).	27805510
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Leptin level increase significantly within 3 months after fetal pancreatic stem cell transplant in patients with type 2 diabetes mellitus.	27805510
Colorectal Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	A comparison of cancer stem cell markers and nonclassical major histocompatibility complex antigens in colorectal tumor and noncancerous tissues.	27806848
Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	Cancer stem cells (CSCs) are associated with poor prognosis, metastasis, and recurrence, as well as chemotherapy and radiotherapy resistance.	27806848
Barrett Esophagus, Adenocarcinoma Of Esophagus	Stem Cell Exhaustion	Goblet Cell Ratio in Combination with Differentiation and Stem Cell Markers in Barrett Esophagus Allow Distinction of Patients with and without Esophageal Adenocarcinoma.	27807078
Neoplasms	Stem Cell Exhaustion	Increasing stem cell marker LGR5 and niche cell marker DCLK1 and decreasing differentiation marker (secretory mucus cells, TFF2+ cells) correlated with elevated tumor score in the mouse.	27807078
Graft-vs-Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	CD4+ regulatory T cells (CD4Tregs) play a critical role in the maintenance of immune tolerance and prevention of chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation.	27812545
Febrile Neutropenia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We retrospectively evaluated the use of computed tomography abdomen and pelvis (CTAP) in febrile neutropenic autologous stem cell transplant (ASCT) and acute myeloid leukaemia (AML) patients.	27813352
Colorectal Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	The CEA-/lo colorectal cancer cell population harbors cancer stem cells and metastatic cells.	27813496
Colorectal Carcinoma	Stem Cell Exhaustion	In this study, 454 primary colorectal carcinomas were analyzed histologically and immunohistochemically for CD274, mismatch repair (MMR) proteins, intestinal differentiation marker (CDX2), and stem cell markers (ALCAM, ALDH1A1, and SALL4).	27813511
Exocrine pancreas	Stem Cell Exhaustion	Pancreatic duct glands (PDGs) have been proposed as a source of regeneration in response to exocrine pancreas injury, and thus may serve as an organ stem cell niche.	27813705
Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8	Stem Cell Exhaustion	To investigate the PDG compartment of the pancreas in humans with T1D for evidence of an active regenerative signature (presence of progenitor cells and increased proliferation) and, in particular, as a potential source of b-cells.	27813705
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	In this study we evaluated the ability of circulating stem cell levels to predict future cardiovascular outcomes and improve risk discrimination in patients with type 2 diabetes.	27815289
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Long-term Prediction of Cardiovascular Outcomes by Circulating CD34+ and CD34+CD133+ Stem Cells in Patients With Type 2 Diabetes.	27815289
Cessation of life, Diabetes	Stem Cell Exhaustion	Circulating stem cells predict future cardiovascular events and death, but data for the population with diabetes are scant.	27815289
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	In patients with type 2 diabetes, a reduced baseline level of circulating CD34+ stem cells predicts adverse cardiovascular outcomes up to 6 years later and improves risk stratification.	27815289
leukemia	Stem Cell Exhaustion	Sequential Intensified Conditioning Regimen Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients with Intermediate- or High-Risk Acute Myeloid Leukemia in Complete Remission: A Study from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation.	27816650
Failure, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Post-transplant relapse is the leading cause of treatment failure in acute myeloid leukemia (AML) patients after reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation (allo-HSCT).	27816650
Acute lymphocytic leukemia	Stem Cell Exhaustion	Clofarabine Plus Busulfan is an Effective Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Acute Lymphoblastic Leukemia: Long-Term Study Results.	27816651
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	busulfan (Bu) combined with clofarabine (Clo) in patients with acute lymphoblastic leukemia (ALL) undergoing allogeneic hematopoietic stem cell transplantation (HSCT).	27816651
Graft-vs-Host Disease	Stem Cell Exhaustion	Consequently, patients can be offered hematopoietic stem cell transplantation (HSCT) from alternative donors, including mismatched unrelated donors (MMURD), known to cause a higher incidence of acute GVHD (aGVHD) and chronic GVHD.	27819684
Extrahepatic Cholangiocarcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Aberrant activation of Notch signaling in extrahepatic cholangiocarcinoma: clinicopathological features and therapeutic potential for cancer stem cell-like properties.	27821106
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Notch signaling has been reported to be related to cancer stem cell (CSC) like properties in some malignancies.	27821106
Leukemia, Myelocytic, Acute, Acute leukemia	Stem Cell Exhaustion	Long-term survival and late events after allogeneic stem cell transplantation from HLA-matched siblings for acute myeloid leukemia with myeloablative compared to reduced-intensity conditioning: a report on behalf of the acute leukemia working party of European group for blood and marrow transplantation.	27821187
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Myeloablative (MAC) and reduced-intensity conditioning (RIC) are established approaches for allogeneic stem cell transplantation (SCT) in acute myeloid leukemia (AML).	27821187
Infection	Stem Cell Exhaustion	Risk Factors and Outcomes of Infections by Multidrug-Resistant Gram-Negative Bacteria in Patients Undergoing Hematopoietic Stem Cell Transplantation.	27826061
Infection, Multi-Drug Resistance	Stem Cell Exhaustion	The objective of this study was to determine risk factors and outcomes of infections by multidrug-resistant gram-negative (MDR GN) bacteria in 241 recipients of hematopoietic stem cell transplantation (HSCT).	27826061
Aggressive natural killer-cell leukemia	Stem Cell Exhaustion	Achievement of disease control with donor-derived EB virus-specific cytotoxic T cells after allogeneic peripheral blood stem cell transplantation for aggressive NK-cell leukemia.	27830541
Brain Diseases, Metabolic, Inborn, Degenerative disorder, Single organ dysfunction	Stem Cell Exhaustion	Different types of stem cells with hepatic differentiation potential are eligible for generating large numbers of functional hepatocytes for liver cell therapy to treat degenerative disorders, inborn hepatic metabolic diseases, and organ failure.	27830543
Hematologic Neoplasms, Malignant Neoplasms, Diabetes Mellitus	Stem Cell Exhaustion	Underlying conditions were haematological malignancies (46 %), other malignancies (6.3 %), haematopoietic stem cell transplantation (15.9 %), solid organ transplantation, trauma/surgery and diabetes mellitus (4.8 % each) and a variety of other diseases (7.9 %); in 9.5%, no underlying medical condition was found.	27832748
Cessation of life	Stem Cell Exhaustion	In regression analysis, disseminated disease and prior haematopoietic stem cell transplantation were associated with increased odds of death, whereas the combination of systemic antifungal therapy with surgery was associated with improved survival.	27832748
Specialty Type - cancer, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Aldehyde dehydrogenase 1 (ALDH1), a marker of cancer stem cells, is also associated with metastasis and poor prognosis in many tumors.	27832750
Liver carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	miR-589-5p inhibits MAP3K8 and suppresses CD90+ cancer stem cells in hepatocellular carcinoma.	27835990
Liver carcinoma, Specialty Type - cancer, Hollings Cancer Center	Stem Cell Exhaustion	Cancer stem cells (CSCs) are important in the tumorigenesis and progression of hepatocellular carcinoma (HCC).	27835990
Coronary Arteriosclerosis	Stem Cell Exhaustion	Circulating osteogenic endothelial progenitor cell counts: new biomarker for the severity of coronary artery disease.	27836295
Atherosclerosis	Stem Cell Exhaustion	There is increasing evidence implying that the early and functionally highly active circulating endothelial progenitor cell (CEPC) phenotype (CD34-/CD133+/KDR+) with osteogenic potential (OCN+) might link between vascular atherosclerotic calcification and mechanisms of bone metabolism.	27836295
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)	Stem Cell Exhaustion	Subsequent vitiligo after hematopoietic stem cell transplantation: A nationwide population-based cohort study from Korea.	27836331
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)	Stem Cell Exhaustion	Subsequent vitiligo after hematopoietic stem cell transplantation (HSCT) has been described sporadically in case series.	27836331
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)	Stem Cell Exhaustion	Allogeneic HSCT (OR 5.593, 95% CI 1.628-19.213) and bone marrow-sourced stem cells (as compared with peripheral blood-sourced stem cells; OR 2.492, 95% CI 1.114-5.576) were independently associated with the development of vitiligo after HSCT.	27836331
Hematopoietic stem cells, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The myelodysplastic syndromes (MDS) are a heterogeneous group of clonal haematopoietic stem cell disorders characterised by inefficient haematopoiesis and risk of progression to acute myeloid leukaemia.	27836923
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	The distribution of CD44+/CD24- cancer stem cells in breast cancer and its relationship with prognostic factors.	27837613
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	The purpose of this study was to investigate the correlation between the percentages of CD44+/CD24- cancer stem cells (CSCs) and the clinicopathological and prognostic factors in breast cancer patients.	27837613
Specialty Type - cancer	Stem Cell Exhaustion	Pupose: Nestin and CD133 are regarded as putative markers of cancer stem cells (CSCs) and related to poor prognosis in various cancer sites.	27837619
Peripheral Blood Stem Cells	Stem Cell Exhaustion	Although autologous stem cell transplantation can achieve excellent responses in patients with POEMS syndrome, the optimal regimen for peripheral blood stem cell (PBSC) collection is still controversial.	27840209
Cessation of life, HCK gene	Stem Cell Exhaustion	Herein, we describe a new specific pharmacological hematopoietic cell kinase (HCK) inhibitor (iHCK-37) that was able to reduce PI3K/AKT and MAPK/ERK pathways activation after erythropoietin induction in cells with high HCK expression: iHCK-37 treatment increased leukemic cells death and, very importantly, did not affect normal hematopoietic stem cells.	27840303
MYELODYSPLASTIC SYNDROME, PAFAH1B1 wt Allele, HCK gene, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Notably, HCK levels were highly increased in stem cells from patients with some diseases, as Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML), that are associated with ineffective erythropoiesis These discoveries support the exploration of the new pharmacological iHCK-37 in future preclinical and clinical studies.	27840303
Reperfusion Injury	Stem Cell Exhaustion	The cell type that survives and maintains stem cell characteristics in the adverse microenvironment following ischemia-reperfusion injury is presumed to be ideal for transplantation.	27844250
Microbiological, Communicable Diseases	Stem Cell Exhaustion	Rates of Microbiologically Diagnosed Infection and Pathogen Detection in Hematopoietic Stem Cell Transplant Patients.	27849508
Infection	Stem Cell Exhaustion	Infections remain a significant cause of mortality in hematopoietic stem cell transplant patients.	27849508
Communicable Diseases	Stem Cell Exhaustion	We performed a retrospective analysis of infection rates and microbiologic testing yield, or percent of tests ordered to diagnose an infection, in the first 100 days of 30 allogeneic and 56 autologous stem cell transplants performed at San Antonio Military Medical Center from July 2011 to April 2014.	27849508
Communicable Diseases	Stem Cell Exhaustion	Improved diagnostic tests and methods are needed to increase yield of detection of infection in hematopoietic stem cell transplant patients.	27849508
Fibrosis Assessment, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Early Improvement in Marrow Fibrosis Following Haploidentical Stem Cell Transplantation for a Patient with Myelodysplastic Syndrome with Bone Marrow Fibrosis.	27853082
Myeloproliferative disease	Stem Cell Exhaustion	Myeloproliferative neoplasms are clonal hematopoietic stem cell disorders characterized by aberrant proliferation and an increased tendency toward leukemic transformation.	27855276
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Comprehensive recommendations for maintenance therapy after autologous stem cell transplantation (ASCT) for patients with multiple myeloma (MM) have yet to be defined.	27856369
Colonization, Communicable Diseases	Stem Cell Exhaustion	Chlorhexidine bathing for the prevention of colonization and infection with multidrug-resistant microorganisms in a hematopoietic stem cell transplantation unit over a 9-year period: Impact on chlorhexidine susceptibility.	27861350
Infection, Thais (Population Group)	Stem Cell Exhaustion	Health care associated infections (HAIs) are currently among the major challenges to the care of hematopoietic stem cell transplantation (HSCT) patients.	27861350
Disseminated, Candidiasis	Stem Cell Exhaustion	Thalidomide for steroid-dependent chronic disseminated candidiasis after stem cell transplantation: A case report.	27862711
Hepatic Vein Thrombosis	Stem Cell Exhaustion	Number and function of circulating endothelial progenitor cells in patients with primary Budd-Chiari syndrome.	27863925
Endothelium	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPCs) provide an endogenous mechanism to repair endothelial injury.	27863925
leukemia	Stem Cell Exhaustion	The long-term outcome of reduced-intensity allogeneic stem cell transplantation from a matched related or unrelated donor, or haploidentical family donor in patients with leukemia: a retrospective analysis of data from the China RIC Cooperative Group.	27864604
Precapillary pulmonary hypertension	Stem Cell Exhaustion	Effect of targeted therapy on circulating progenitor cells in precapillary pulmonary hypertension.	27865192
Endothelial dysfunction, Pulmonary Hypertension	Stem Cell Exhaustion	Endothelial dysfunction is key in the development of pulmonary hypertension (PH) and is associated with reduced number of circulating progenitor cells.	27865192
Pulmonary Hypertension	Stem Cell Exhaustion	PAH-targeted therapy increases levels of progenitors in PAH but not in CTEPH, suggesting different involvement of progenitor cells in the pathobiology of these pulmonary hypertensive disorders.	27865192
White matter lesions	Stem Cell Exhaustion	To understand how the microenvironment within white matter lesions plays a role in repair we have focused on neural progenitor cells (NPCs) since these are found in lesions in PPMS and have been found to influence oligodendrocyte progenitor cell maturation (OPCs).	27865736
Traumatic AND/OR non-traumatic injury	Stem Cell Exhaustion	iPS-derived neural progenitor cells from PPMS patients reveal defect in myelin injury response.	27865736
Stomach Carcinoma	Stem Cell Exhaustion	However, peripheral levels of IL-23 were correlated with the absolute numbers of circulating populations of bone marrow-derived mesenchymal and very small embryonic/epiblast-like stem cells in patients with gastric carcinoma.	27869179
Multiple Myeloma	Stem Cell Exhaustion	Absence of spontaneous response improvement beyond day +100 after autologous stem cell transplantation in multiple myeloma.	27869809
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The response evaluation after autologous stem-cell transplantation (ASCT) is usually performed at day +100 in patients with multiple myeloma (MM).	27869809
Neoplasms, Relapsing course	Stem Cell Exhaustion	High-Dose Chemotherapy and Autologous Peripheral-Blood Stem-Cell Transplantation for Relapsed Metastatic Germ Cell Tumors: The Indiana University Experience.	27870561
Hypoxia, Reperfusion Injury	Stem Cell Exhaustion	We evaluated the role of donor age and hypoxia of human pediatric cardiac progenitor cell (CPC)-derived exosomes in a rat model of ischemia-reperfusion injury.	27872050
Morular Metaplasia of the Endometrium, Chemotherapy-induced nausea and vomiting, Multiple Myeloma, Chemotherapy-induced Nausea and Vomiting Questionnaire	Stem Cell Exhaustion	Chemotherapy-induced nausea and vomiting (CINV) is a significant side effect in multiple myeloma (MM) patients receiving high-dose melphalan treatment followed by autologous stem cell transplantation (ASCT).	27873176
Bone Marrow	Stem Cell Exhaustion	Furthermore, triplet regimen downregulated the expression of CXCR4, a chemokine receptor essential for bone marrow retention, on CD34+ cells, suggesting an unexpected effect on normal hematopoietic stem/progenitor cells through the reduced interaction with the bone marrow microenvironment.	27873175
Neoplasms	Stem Cell Exhaustion	There was no significant difference in MRI findings between pathologic tumor types (classical type versus stem cell feature type, P = 0.324-1.0).	27875000
NOTCH3 wt Allele	Stem Cell Exhaustion	We assessed plasma levels of von Willebrand factor (vWF) and thrombomodulin (TM) and the blood levels of endothelial progenitor cells (EPCs) and circulating progenitor cells (CPCs) in 49 CADASIL patients and 49 age-matched controls and their association with clinical/functional and neuroimaging features.	27876311
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Using microbeads, CD133+ cells were isolated and were found to possess glioma stem cell properties.	27878295
Glioblastoma Multiforme Pathway, Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	Long non-coding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) significantly contributes to the progression of many human cancers, while glioma stem cells (GSCs) are believed to be responsible for tumor progression.	27878295
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	We found higher NEAT1 RNA expression in CD133+ human glioma primary culture stem cells and CD133+ U87 cells via RT-PCR.	27878295
Primary amyloidosis	Stem Cell Exhaustion	Pre-transplantation novel agent induction predicts progression-free survival for patients with immunoglobulin light-chain amyloidosis undergoing high-dose melphalan and autologous stem cell transplantation.	27879147
Amyloidosis	Stem Cell Exhaustion	High-dose melphalan and autologous stem cell transplantation (HDM/SCT) is an effective treatment modality for immunoglobulin light-chain (AL) amyloidosis; however, its application remains restricted to patients with good performance status and limited organ involvement.	27879147
Ataxia Telangiectasia Mutated Proteins	Stem Cell Exhaustion	Integration-free erythroblast-derived human induced pluripotent stem cells (iPSCs) from an individual with Ataxia-Telangiectasia (A-T).	27879207
BCL2L1 gene	Stem Cell Exhaustion	Blood erythroid cells were briefly expanded in vitro and induced pluripotent stem cells (iPSCs) were generated via transfection with episomal vectors carrying hOCT4, hSOX2, hKLF4, hMYC and hBCL2L1.	27879207
Spastic Paraplegia, Hereditary	Stem Cell Exhaustion	Generation of induced pluripotent stem cells (iPSCs) from a hereditary spastic paraplegia patient carrying a homozygous R486C mutation in CYP7B1 (SPG5).	27879216
Optic Atrophy	Stem Cell Exhaustion	Generation of optic atrophy 1 patient-derived induced pluripotent stem cells (iPS-OPA1-BEHR) for disease modeling of complex optic atrophy syndromes (Behr syndrome).	27879217
Xanthomatosis	Stem Cell Exhaustion	Induced pluripotent stem cells (iPSCs) derived from cerebrotendinous xanthomatosis (CTX) patient's fibroblasts carrying a R395S mutation.	27879219
Xanthomatosis	Stem Cell Exhaustion	Induced pluripotent stem cells (iPSCs) were generated from dermal fibroblasts from a 60-year-old cerebrotendinous xanthomatosis (CTX) patient, carrying a homozygous mutation c. [1183C>A]; p. R395S in CYP27A1.	27879219
Spastic Paraplegia, Hereditary	Stem Cell Exhaustion	Generation of induced pluripotent stem cells (iPSCs) from a hereditary spastic paraplegia patient carrying a homozygous Y275X mutation in CYP7B1 (SPG5).	27879220
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Sequential chemotherapy followed by reduced-intensity conditioning and allogeneic haematopoietic stem cell transplantation in adult patients with relapse or refractory acute myeloid leukaemia: a survey from the Acute Leukaemia Working Party of EBMT.	27879990
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This study analysed the outcome of 267 patients with relapse/refractory acute myeloid leukaemia (AML) who received sequential chemotherapy including fludarabine, cytarabine and amsacrine followed by reduced-intensity conditioning (RIC) and allogeneic haematopoietic stem cell transplantation (HSCT).	27879990
Disease remission	Stem Cell Exhaustion	Active disease came under control with this; however, the patient gradually developed limbal stem cell deficiency.	27881591
Anemia, Hemolytic, Decreased platelet count	Stem Cell Exhaustion	TA-TMA is a post-hematopoietic stem cell transplant complication with clinical features of hemolytic anemia and thrombocytopenia.	27882637
Mediastinal (Thymic) Large B-Cell Lymphoma	Stem Cell Exhaustion	Our aim was to retrospectively investigate the data from our institute the response rate and outcome in patients with primary mediastinal B-cell lymphoma (PMBL) who received the rituximab in combination with CHOP (RCHOP) followed by autologous stem cell transplantation (ASCT) or RCHOP followed by involved field radiation therapy (IFRT).	27884092
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Here, trophoblast cell surface antigen 2 (TROP2), a protein implicated in the regulation of stem cell activity, was examined in lung tissue samples from COPD patients.	27887617
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Abnormal airway regeneration observed in COPD is thought to originate in the stem/progenitor cells of the airway epithelium, the basal cells (BCs).	27887617
Acute lymphocytic leukemia	Stem Cell Exhaustion	Co-infusion of haplo-identical CD19-chimeric antigen receptor T cells and stem cells achieved full donor engraftment in refractory acute lymphoblastic leukemia.	27887660
BCR gene	Stem Cell Exhaustion	We treated a 71-year-old female with relapsed and refractory ALL who received co-infusion of haplo-identical donor-derived CD19-directed CAR-T cells and mobilized peripheral blood stem cells (PBSC) following induction chemotherapy.	27887660
Graft-vs-Host Disease	Stem Cell Exhaustion	We previously completed a "first-in-human" clinical trial using in vitro expanded umbilical cord blood (UCB)-derived tTreg to prevent GVHD in patients undergoing UCB hematopoietic stem cell transplantation (HSCT).	27887864
Non-Neoplastic Hematologic and Lymphocytic Disorder	Stem Cell Exhaustion	Haploidentical stem cell transplantation (SCT) is increasingly used to treat pediatric patients with malignant or nonmalignant hematological disorders.	27888540
Bacteremia	Stem Cell Exhaustion	Vancomycin-Resistant Enterococcus Colonization and Bacteremia and Hematopoietic Stem Cell Transplantation Outcomes.	27890428
Vancomycin-Resistant Enterococci, Colonization	Stem Cell Exhaustion	The association between pre-hematopoietic stem cell transplantation (HSCT) vancomycin-resistant Enterococcus (VRE) colonization, HSCT-associated VRE bacteremia, and HSCT mortality is disputed.	27890428
Idiopathic Pulmonary Fibrosis	Stem Cell Exhaustion	Allogeneic Human Mesenchymal Stem Cells in Patients With Idiopathic Pulmonary Fibrosis via Intravenous Delivery (AETHER): A Phase I Safety Clinical Trial.	27890713
Idiopathic Pulmonary Fibrosis	Stem Cell Exhaustion	The Allogeneic Human Cells (hMSC) in patients with Idiopathic Pulmonary Fibrosis via Intravenous Delivery (AETHER) trial was the first study designed to evaluate the safety of a single infusion of bone marrow-derived mesenchymal stem cells in patients with idiopathic pulmonary fibrosis.	27890713
Idiopathic Pulmonary Fibrosis	Stem Cell Exhaustion	Nine patients with mild to moderate IPF were sequentially assigned to 1 of 3 cohorts and dosed with a single IV infusion of 20, 100, or 200 x 106 human bone marrow-derived mesenchymal stem cells per infusion from young, unrelated, men.	27890713
Idiopathic Pulmonary Fibrosis	Stem Cell Exhaustion	Data from this trial support the safety of a single infusion of human mesenchymal stem cells in patients with mild-moderate IPF.	27890713
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GVHD) is a complication of allogeneic hematopoietic stem cell transplantation with high morbidity and mortality.	27891662
Dysautonomia, Familial	Stem Cell Exhaustion	To clarify the influence of exposure to a male fetus during a female donor's (FD) pregnancy in allogeneic hematopoietic stem cell transplantation (HSCT), we retrospectively examined 292 HSCT patients.	27892749
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	This study aimed to analyze the use of the revised International Prognostic Scoring System (IPSS-R) assessed after hypomethylating treatment (HMT) for patients with myelodysplastic syndrome (MDS) undergoing an allogeneic stem cell transplantation (SCT).	27892952
Prostate carcinoma, Passive Cutaneous Anaphylaxis, Secondary malignant neoplasm of prostate	Stem Cell Exhaustion	Here we demonstrate for the first time that a microRNA component of this region-miR-383-is frequently downregulated in prostate cancer, has a critical role in determining tumor-initiating potential and is involved in prostate cancer metastasis via direct regulation of CD44, a ubiquitous marker of PCa tumor-initiating cells (TICs)/stem cells.	27893706
Childhood Breast Carcinoma	Stem Cell Exhaustion	New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate.	27894093
Transcription Initiation, Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	Cancer stem cells (CSCs) play major roles in cancer initiation, metastasis, recurrence and therapeutic resistance.	27894093
Pituitary Adenoma	Stem Cell Exhaustion	Using a nanoString-based 80-gene custom codeset specific for developmental pathways, we identified a differential stem cell gene expression profile within human pituitary adenomas.	27894339
Adenoma	Stem Cell Exhaustion	Prospective functional characterization of stem cell properties in patient-derived adenomas representing all hormonal subtypes yielded a subtype-dependent self-renewal profile, which was enriched within the CD15+ cell fraction.	27894339
BRAF NP_004324.2:p.V600E, Disease	Stem Cell Exhaustion	Both diseases seem to be linked by a mutation in oncogenic BRAFV600E, probably an early event which occurs in bone marrow progenitor cells.	27898473
Virus Reactivation, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Prognostic impact of viral reactivations in acute myeloid leukemia patients undergoing allogeneic stem cell transplantation in first complete response.	27902595
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Cytomegalovirus (CMV) serological status of donor and recipient as well as CMV reactivation have been associated with a lower risk of relapse in acute myeloid leukemia (AML) patients after allogeneic stem cell transplantation (alloSCT).	27902595
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	To investigate the incidence, risk factors and survival of conjunctival acute graft-versus-host disease (aGVHD) in adult patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT).	27902756
Paroxysmal nocturnal hemoglobinuria, PIGA gene	Stem Cell Exhaustion	We investigate clonal relationships of various NK-cell subsets, including the adaptive population, by taking advantage of naturally occurring X-linked somatic PIGA mutations in hematopoietic stem and progenitor cells (HSPCs) from patients with paroxysmal nocturnal hemoglobinuria (PNH).	27903532
Chronic active Epstein-Barr virus infection	Stem Cell Exhaustion	Successful Cord Blood Stem Cell Transplantation for an Adult Case of Chronic Active Epstein-Barr Virus Infection.	27904117
Chronic Epstein-Barr virus infection syndrome	Stem Cell Exhaustion	Chronic active Epstein-Barr virus (CAEBV) was diagnosed based on the findings of elevated EBV antibody titers and positive EBV-DNA in the peripheral blood, and cord blood stem cell transplantation (CBT) was performed.	27904117
Specialty Type - cancer	Stem Cell Exhaustion	Among studied proteins, there are some that are anti-apoptotic, pro-proliferative, cancer stem cell markers and the Vitamin D Receptor.	27905097
hepcidin, Hematologic Neoplasms	Stem Cell Exhaustion	We previously reported dynamic changes of serum hepcidin-25 levels in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation (allo-HSCT).	27905193
Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Combination of anti-retroviral therapy, high-dose chemotherapy (HCT) and autologous stem cell transplantation (ASCT) has led to an improved survival of HIV+ non-Hodgkin lymphoma (NHL) patients.	27905485
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Autologous stem cell transplantation for adult acute myelocytic leukemia in first remission-Better outcomes after busulfan and melphalan compared with busulfan and cyclophosphamide: A retrospective study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT).	27906458
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) for adult acute myelogenous leukemia (AML) is a valid therapeutic option for patients with good-risk and intermediate-risk disease.	27906458
Neoplasms	Stem Cell Exhaustion	The NOTCH signaling pathway may be involved in the survival of stem cell-like tumor-initiating cells and contribute to tumor growth.	27906684
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Similar outcome after allogeneic stem cell transplantation with a modified FLAMSA conditioning protocol substituting 4 Gy TBI with treosulfan in an elderly population with high-risk AML.	27909887
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The fludarabine, amsacrine, and cytarabine (FLAMSA)-reduced-intensity conditioning (RIC) protocol has been described to be effective in patients with high-risk and refractory acute myeloic leukemia (AML) undergoing allogeneic hematopoietic stem cell transplantation (aSCT).	27909887
Neutropenia, Infection	Stem Cell Exhaustion	Few studies have been performed to identify factors that are associated with an increased risk of infections during the neutropenic period in patients undergoing allogeneic stem cell transplantation (allo-SCT).	27910184
Deficiency	Stem Cell Exhaustion	Transplantation of in vitro cultured limbal epithelial stem cells (LESCs) is a treatment widely used for LESC deficiency.	27911610
Specialty Type - cancer, Neoplasms, Hypoxia	Stem Cell Exhaustion	HPV status, cancer stem cell marker expression, hypoxia gene signatures and tumour volume identify good prognosis subgroups in patients with HNSCC after primary radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG).	27913065
Hypoxia, Squamous cell carcinoma of the head and neck, Neoplasms, Specialty Type - cancer, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology	Stem Cell Exhaustion	To investigate the impact of the tumour volume, HPV status, cancer stem cell (CSC) marker expression and hypoxia gene signatures, as potential markers of radiobiological mechanisms of radioresistance, in a contemporary cohort of patients with locally advanced head and neck squamous cell carcinoma (HNSCC), who received primary radiochemotherapy (RCTx).	27913065
Inflammation	Stem Cell Exhaustion	Patients presented inflammation syndrome and high levels of CXCL12, soluble stem cell factor and granulocyte colony-stimulating factor, whereas granulocyte macrophage colony-stimulating factor was low.	27914820
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) represents the cornerstone of treatment in pediatric high-risk and relapsed acute myeloid leukemia (AML).	27916512
440	Stem Cell Exhaustion	For 440 patients, bone marrow was used as stem cell source, and 191 patients received peripheral blood stem cells.	27916512
Tuberculosis	Stem Cell Exhaustion	Intestinal Pneumatosis Associated with Tuberculosis after Allogeneic Hematopoietic Stem Cell Transplantation.	27923223
Abdominal symptom, Fever, Multiple Myeloma	Stem Cell Exhaustion	Here, we report on a 56-year-old female with multiple myeloma who presented with undulating fever, fluctuating abdominal symptoms, and a distended abdomen 5 months after allogeneic hematopoietic stem cell transplantation (HSCT).	27923223
Disease remission, Specialty Type - cancer, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Outcomes of allogeneic stem cell transplantation among patients with acute myeloid leukemia presenting active disease: Experience of a single European Comprehensive Cancer Center.	27925043
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (ASCT) representes a potentially curative approach for patients with relapsed or refractory acute myeloid leukemia (AML).	27925043
Malignant neoplasm of liver	Stem Cell Exhaustion	HBx drives alpha fetoprotein expression to promote initiation of liver cancer stem cells through activating PI3K/AKT signal pathway.	27925189
Hollings Cancer Center	Stem Cell Exhaustion	Altogether, HBx stimulates AFP expression to induce natural reprogramming of liver cells, and AFP plays a critical role in promoting the initiation of HCC progenitor/stem cells.	27925189
Up	Stem Cell Exhaustion	Here, we used induced pluripotent stem cells (iPSCs) derived from somatic cells of familial AD patients carrying PSEN1 mutations to study the early pathogenic event of AD.	27926491
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Prognosis of patients with peripheral T cell lymphoma who achieve complete response after CHOP/CHOP-like chemotherapy without autologous stem cell transplantation as an initial treatment.	27928587
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Because the long-term outcome of patients with PTCL, especially those achieving complete response (CR), has not been fully elucidated, we retrospectively analyzed 78 consecutive patients initially treated with CHOP/CHOP-like chemotherapy, without high-dose chemotherapy followed by autologous stem cell transplantation (HDC/auto-SCT).	27928587
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	A 19-year-old male patient with acute myeloid leukemia received a human leukocyte antigen-haploidentical stem cell transplant as a second transplant while in second complete remission.	27930567
Pancreatitis	Stem Cell Exhaustion	After a second stem cell transplant, obstructive pancreatitis accompanied by a mass in the pancreatic head was observed.	27930567
Specialty Type - cancer, Malignant neoplasm of stomach, Neoplasms	Stem Cell Exhaustion	We examined the relationship between the presence of cancer stem cells (CSCs) at the invasive tumour front and prognosis in gastric cancer (GC).	27931044
Lymphoma, Follicular	Stem Cell Exhaustion	Survival for transformed follicular lymphoma (tFL) has improved in the rituximab era and the need for upfront stem cell transplantation (SCT) is unclear.	27931133
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	A 65-year-old man underwent peripheral blood stem cell transplantation (PBSCT) from his human leukocyte antigen (HLA)-haploidentical son for the treatment of acute myeloid leukemia, which had evolved from a myelodysplastic syndrome (MDS).	27932186
Moyamoya Disease	Stem Cell Exhaustion	Establishment of induced pluripotent stem cell (iPSC) line from 55-year old male patient with hemorrhagic Moyamoya disease.	27934594
Leukoencephalopathy	Stem Cell Exhaustion	Sequential Onset of Varicella-Zoster Virus Encephalomeningitis and Progressive Multifocal Leukoencephalopathy in an Allogeneic Hematopoietic Stem Cell Transplant Recipient.	27938314
herpesvirus 3, human, Leukoencephalopathy	Stem Cell Exhaustion	Here, we describe a case of sequential varicella-zoster virus encephalomeningitis and progressive multifocal leukoencephalopathy following an allogeneic hematopoietic stem cell transplant procedure.	27938314
Graft-vs-Host Disease	Stem Cell Exhaustion	The gold standard in the diagnosis of gastrointestinal graft-versus-host disease (GVHD) after allogenic hematopoietic stem cell transplantation is conventional endoscopy with histopathological assessment.	27941359
Fatigue, Depression, CTCAE, Cognitive problems	Stem Cell Exhaustion	Cognitive problems following hematopoietic stem cell transplant: relationships with sleep, depression and fatigue.	27941775
Cognitive problems	Stem Cell Exhaustion	Cognitive problems are a significant, persistent concern for patients undergoing hematopoietic stem cell transplant (HSCT).	27941775
Prolymphocytic Leukemia	Stem Cell Exhaustion	Allogeneic stem cell transplantation (alloSCT) is used for treating patients with T-prolymphocytic leukemia (T-PLL).	27941777
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Pre-transplant persistence of minimal residual disease does not contraindicate allogeneic stem cell transplantation for adult patients with acute myeloid leukemia.	27941782
Graft-vs-Host Disease	Stem Cell Exhaustion	To test the feasibility of mycophenolate mofetil (MMF) for graft-versus-host disease (GVHD) prophylaxis in Japanese patients, we conducted two multicenter prospective phase II trials of allogeneic hematopoietic stem-cell transplantation (HSCT) from HLA-matched related donors (MRD group) with MMF and cyclosporine or HLA 7-8/8 allele-matched unrelated bone-marrow donors (URD group) with MMF and tacrolimus.	27943166
Clostridium difficile colitis	Stem Cell Exhaustion	Risk factors and epidemiology of Clostridium difficile infection in hematopoietic stem cell transplant recipients during the peritransplant period.	27943501
Clostridium difficile, Central Diabetes Insipidus, Communicable Diseases	Stem Cell Exhaustion	Hematopoietic stem cell transplant (HSCT) recipients represent a high-risk group for developing Clostridium difficile (CD) infection (CDI).	27943501
Ulcer	Stem Cell Exhaustion	The medial ulcer was treated with transplantation of autologous adipose mesenchymal stem cell (AMSC)-enriched, high-density lipoaspirate (HDL) on OASIS wound matrix and compression therapy.	27943665
Coronary Arteriosclerosis	Stem Cell Exhaustion	Although shorter LTL is associated with decreased regenerative capacity, both LTL and circulating progenitor cell levels are independent and additive predictors of adverse cardiovascular outcomes in coronary artery disease patients.	27956416
Neurodegenerative Disorders	Stem Cell Exhaustion	Engulfment of synapses and neural progenitor cells (NPCs) by microglia is critical for the development and maintenance of proper brain circuitry, and has been implicated in neurodevelopmental as well as neurodegenerative disease etiology.	27956744
Chronic heart failure	Stem Cell Exhaustion	The effect of serum on the proliferation of bone marrow-derived mesenchymal stem cells from aged donors and donors with or without chronic heart failure.	27957821
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Bismuth adjuvant ameliorates adverse effects of high-dose chemotherapy in patients with multiple myeloma and malignant lymphoma undergoing autologous stem cell transplantation: a randomised, double-blind, prospective pilot study.	27966023
Neutropenia, Bacteremia, Gastrointestinal mucositis	Stem Cell Exhaustion	High-dose chemotherapy prior to autologous stem cell transplantation (ASCT) leads to adverse effects including mucositis, neutropenia and bacteremia.	27966023
glycation	Stem Cell Exhaustion	Pre-existing Kr5+ progenitor cells produced squamous alveolar cells expressing receptor for advanced glycation endproducts, aquaporin 5, and T1a in alveoli devoid of AEC2s.	27967234
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Consolidation with autologous stem cell transplantation in first remission is safe and effective in AML patients above 65 years.	27978458
Neuromuscular, Injury of sciatic nerve	Stem Cell Exhaustion	Human Induced Pluripotent Stem Cell-Derived Motor Neuron Transplant for Neuromuscular Atrophy in a Mouse Model of Sciatic Nerve Injury.	27978547
gastrointestinal, Communicable Diseases	Stem Cell Exhaustion	Objective Conditioning regimens for hematopoietic stem cell transplantation (HSCT) are well known to cause severe gastrointestinal toxicities that often disturb the oral intake of the patients followed by poor nutrition and life-threatening infection.	27980254
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Relevance of prognostic factors in the decision-making of stem cell transplantation in Myelodysplastic Syndromes.	27982317
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	The hematopoietic stem cell transplantation (HSCT) is the only curative alternative for Myelodysplastic Syndrome (MDS), but many patients are not eligible for this treatment, as there are several limiting factors, especially in the case of patients with low-risk MDS.	27982317
Chemosensitivity, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Rituximab-containing salvage chemotherapy followed by high-dose therapy and autologous stem cell transplant (ASCT) in chemosensitive patients remains the standard of care for patients with relapsed and refractory diffuse large B-cell lymphoma (DLBCL).	27982423
Fracture, Degenerative polyarthritis	Stem Cell Exhaustion	Differential analysis of genome-wide methylation and gene expression in mesenchymal stem cells of patients with fractures and osteoarthritis.	27982725
Multiple Myeloma	Stem Cell Exhaustion	Risk stratification in myeloma by detection of circulating plasma cells prior to autologous stem cell transplantation in the novel agent era.	27983726
Multiple Myeloma	Stem Cell Exhaustion	The impact of circulating plasma cells (CPCs) prior to autologous stem cell transplantation (ASCT) for multiple myeloma has not been defined in the novel agent era.	27983726
leukemia	Stem Cell Exhaustion	Graft-Versus-Host Disease in Adolescents and Young Adults (15-24 Years Old) After Allogeneic Hematopoietic Stem Cell Transplantation for Acute Leukemia in First Complete Remission.	27983886
Graft-vs-Host Disease, Acute leukemia	Stem Cell Exhaustion	This study aims to correlate the risk of graft-versus-host disease (GvHD) and age in a population of children and young adults with acute leukemia undergoing hematopoietic stem cell transplantation (HSCT) in first complete remission (CR).	27983886
Hodgkin Disease	Stem Cell Exhaustion	A multi-institutional analysis of peritransplantation radiotherapy in patients with relapsed/refractory Hodgkin lymphoma undergoing autologous stem cell transplantation.	27984652
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	No consensus exists regarding the use of radiotherapy (RT) in conjunction with high-dose chemotherapy and autologous stem cell transplantation (HDC/ASCT) for patients with relapsed/refractory classical Hodgkin lymphoma (HL).	27984652
Rhizomucor	Stem Cell Exhaustion	Cerebral Rhizomucor Infection Treated by Posaconazole Delayed-Release Tablets in an Allogeneic Stem Cell Transplant Recipient.	27988409
Zygomycosis, Mycoses	Stem Cell Exhaustion	Mucormycosis (zygomycosis) is an emerging fungal disease in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients.	27988409
Angioendotheliomatosis	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation for intravascular large B-cell lymphoma: the European Society for Blood and Marrow Transplantation experience.	27991887
Neoplasms	Stem Cell Exhaustion	Tissue-based chimerism analysis enhances detection of donor-derived neoplasia in allogeneic stem cell transplant patients.	27991892
Childhood Breast Carcinoma, Secondary Neoplasm	Stem Cell Exhaustion	The expression of EVI1 and SOX9 is associated with stem cell-like and metastasis signatures, and their depletion impairs the metastatic potential of breast cancer cells.	27991928
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	Aggressive induction chemotherapy followed by autologous haematopoietic stem cell transplant (auto-HCT) is effective for younger patients with mantle cell lymphoma (MCL).	27992063
Aggressive behavior, Neoplasms	Stem Cell Exhaustion	Furthermore, activation of this latter lipid network has been recently demonstrated to confer invasive and stem cell properties to tumor cells promoting tumor aggressiveness and patient relapse.	27992526
Hyperglycemia, Diabetes	Stem Cell Exhaustion	Impact of Hyperglycemia and Low Oxygen Tension on Adipose-Derived Stem Cells Compared with Dermal Fibroblasts and Keratinocytes: Importance for Wound Healing in Type 2 Diabetes.	27992567
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Adipose-derived stem cells (ASC) are currently proposed for wound healing in those with type 2 diabetes mellitus (T2DM).	27992567
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Treatment outcomes for older patients with relapsed/refractory aggressive lymphoma receiving salvage chemotherapy and autologous stem cell transplantation are similar to younger patients: a subgroup analysis from the phase III CCTG LY.12 trial.	27993811
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	High-dose therapy and autologous stem cell transplantation (ASCT) is often considered for older patients (age >60 years) with relapsed/refractory aggressive lymphomas.	27993811
Childhood Breast Carcinoma, Triple-Negative Breast Cancer Finding	Stem Cell Exhaustion	Evaluation of Breast Cancer Stem Cells and Intratumor Stemness Heterogeneity in Triple-negative Breast Cancer as Prognostic Factors.	27994520
Aggressive behavior, Childhood Breast Carcinoma	Stem Cell Exhaustion	Breast cancer stem cells (BCSCs) have been suggested to have tumor-initiating properties, but it remains unclear whether their presence contributes to the increased aggressiveness and poor prognosis of TNBC.	27994520
Lymphoma	Stem Cell Exhaustion	Late Relapses After High-dose Chemotherapy and Autologous Stem Cell Transplantation in Patients With Diffuse Large B-cell Lymphoma in the Rituximab Era.	27998707
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	The standard of care for diffuse large B-cell lymphoma (DLBCL) relapsing after front-line therapy is high-dose chemotherapy and autologous stem cell transplantation (ASCT).	27998707
Non-Small Cell Lung Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	CD133 is a widely used cancer stem cell (CSC) marker, and CD133-positive cancer cells are thought to be tumor-initiating cells with CSC characteristics, while CXCR4, a stromal-derived-factor-1 specific chemokine receptor, is highly expressed in NSCLC tissues and participates in cancer progression by regulating cell anti-apoptosis.	28000861
Acute Promyelocytic Leukemia	Stem Cell Exhaustion	Here, the mechanism of TSY-1 on cellular Telomerase activity was further investigated using HL60, a promyelocytic leukemia cell line, normal peripheral blood mononuclear cells, and CD34+ hematopoietic stem cells derived from umbilical cord blood.	28002788
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Central Nervous System Involvement at the Time of Allogeneic Hematopoietic Stem Cell Transplantation Is Associated with a Poor Outcome in Patients with Acute Myeloid Leukemia.	28004352
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Recent reports suggested that central nervous system (CNS) involvement (CNS+) in patients with acute myeloid leukemia (AML) before allogeneic hematopoietic stem cell transplantation (allo-HSCT) is not an independent predictor of survival after allo-HSCT.	28004352
physiopathological, Chronic Kidney Disease, CTCAE	Stem Cell Exhaustion	Indoxyl Sulfate Impairs Endothelial Progenitor Cells and Might Contribute to Vascular Dysfunction in Patients with Chronic Kidney Disease.	28006782
Hodgkin Disease, Lymphoma	Stem Cell Exhaustion	Myeloablative versus reduced intensity allogeneic stem cell transplantation for relapsed/refractory Hodgkin's lymphoma in recent years: a retrospective analysis of the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation.	28007754
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	To evaluate long-term outcome of myeloablative allogeneic stem cell transplantation (allo-SCT) (MAC) versus reduced-intensity allo-SCT (RIC) in patients with relapsed/refractory Hodgkin's lymphoma (HL) in recent years.	28007754
Specialty Type - cancer	Stem Cell Exhaustion	Spheroid colony formation is used to characterize cancer stem cell (CSCs).	28011472
Specialty Type - cancer, Squamous cell carcinoma	Stem Cell Exhaustion	Podoplanin is a candidate cancer stem cell marker in squamous cell carcinoma (SCC).	28011493
Childhood Breast Carcinoma	Stem Cell Exhaustion	Stable breast cancer cell (BCC) lines are valuable tools for the identification of breast cancer stem cell (BCSC) phenotypes that develop in response to several stimuli as well as for studying the basic mechanisms associated with the initiation and maintenance of BCSCs.	28012234
Childhood Breast Carcinoma	Stem Cell Exhaustion	We isolated BCSCs with high ALDH activity (CD44+ /CD24- /Aldefluorpos ) from a primary culture of human breast cancer tissue and observed that the cells had stem cell properties compared to BCSCs with no ALDH activity (CD44+ /CD24- /Aldefluorneg ).	28012234
Childhood Breast Carcinoma	Stem Cell Exhaustion	Hypoxia promotes the phenotypic change of aldehyde dehydrogenase activity of breast cancer stem cells.	28012234
Aplastic Anemia, CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology	Stem Cell Exhaustion	Severe aplastic anemia (SAA) is a life-threatening hematopoietic stem cell disorder that is treated with bone marrow transplantation (BMT) or immunosuppressive therapy (IST).	28013015
Multiple Myeloma	Stem Cell Exhaustion	Comparison of engraftment following different stem cell mobilization modalities in patients with multiple myeloma treated with a uniform induction regimen containing bortezomib, cyclophosphamide and dexamethasone.	28013359
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Bortezomib-based induction followed by autologous stem cell transplantation is a common treatment for multiple myeloma (MM).	28013359
Multiple Myeloma	Stem Cell Exhaustion	Bortezomib with lenalidomide and dexamethasone versus lenalidomide and dexamethasone alone in patients with newly diagnosed myeloma without intent for immediate autologous stem-cell transplant (SWOG S0777): a randomised, open-label, phase 3 trial.	28017406
Multiple Myeloma	Stem Cell Exhaustion	We aimed to study whether the addition of bortezomib to lenalidomide and dexamethasone would improve progression-free survival and provide better response rates in patients with previously untreated multiple myeloma who were not planned for immediate autologous stem-cell transplant.	28017406
Infection	Stem Cell Exhaustion	The occurrence of infections after allogeneic hematopoietic stem cell transplantation (HCT) is nearly universal.	28017733
leukemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Ex Vivo CD34+-Selected T Cell-Depleted Peripheral Blood Stem Cell Grafts for Allogeneic Hematopoietic Stem Cell Transplantation in Acute Leukemia and Myelodysplastic Syndrome Is Associated with Low Incidence of Acute and Chronic Graft-versus-Host Disease and High Treatment Response.	28017734
Graft-vs-Host Disease	Stem Cell Exhaustion	Ex vivo CD34+-selected T cell depletion (TCD) has been developed as a strategy to reduce the incidence of graft-versus-host disease (GVHD) after allogeneic (allo) hematopoietic stem cell transplantation (HSCT).	28017734
Heart failure	Stem Cell Exhaustion	Patients with symptomatic ischaemic heart failure on guideline-directed therapy (n = 484) were screened; n = 348 underwent bone marrow harvest and mesenchymal stem cell expansion.	28025189
Shock, Cardiogenic	Stem Cell Exhaustion	Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy.	28025189
Alzheimers Disease	Stem Cell Exhaustion	Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells.	28025562
Neurodegenerative Disorders, Up, "Alzheimers Disease	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) have emerged as a promising tool for the treatment of several neurodegenerative disorders, including Alzheimer's disease (AD).	28025562
Dental Surface Disorder	Stem Cell Exhaustion	Allogenic cultivated limbal stem cell transplantation versus cadaveric keratolimbal allograft in ocular surface disorder: 1-year outcome.	28025793
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	We recently reported that peroxisome proliferator-activated receptor g agonists target chronic myeloid leukemia (CML) quiescent stem cells in vitro by decreasing transcription of STAT5.	28026860
Childhood Breast Carcinoma	Stem Cell Exhaustion	Adipocytes are derived from adipose-derived stem cells and express adipocytokines that can facilitate active breast cancer cells in laboratory models.	28027219
Hepatitis B	Stem Cell Exhaustion	Hepatitis B reactivation in occult viral carriers undergoing hematopoietic stem cell transplantation: A prospective study.	28027590
Hepatitis B	Stem Cell Exhaustion	Hepatitis B virus (HBV) reactivation in hepatitis B surface antigen (HBsAg)-negative, antibody to hepatitis B core antigen (anti-HBc)-positive patients after allogeneic hematopoietic stem cell transplantation (HSCT) has not been prospectively studied.	28027590
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Purpose We compared the efficacy of ofatumumab (O) versus rituximab (R) in combination with cisplatin, cytarabine, and dexamethasone (DHAP) salvage treatment, followed by autologous stem-cell transplantation (ASCT) in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL).	28029326
Hypertrophy, Specialty Type - cancer	Stem Cell Exhaustion	growth arrest, hypertrophy, poliploidization and secretory phenotype) and certain properties of cancer stem cells (increased NANOG expression, percentages of CD24+ cells and side population).	28030837
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Stem cell gene signatures predict poor prognosis in AML patients; however, with few exceptions, these deregulated molecular pathways cannot be targeted therapeutically.	28031480
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	CD70/CD27 signaling in AML cells activates stem cell gene expression programs, including the Wnt pathway, and promotes symmetric cell divisions and proliferation.	28031480
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In this study, we demonstrate that the TNF superfamily ligand-receptor pair CD70/CD27 is expressed on AML blasts and AML stem/progenitor cells.	28031480
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Blocking the CD70/CD27 interaction by mAb induced asymmetric cell divisions and differentiation in AML blasts and AML stem/progenitor cells, inhibited cell growth and colony formation, and significantly prolonged survival in murine AML xenografts.	28031480
Infection	Stem Cell Exhaustion	Infections due to alphaherpesviruses in early post-transplant period after allogeneic haematopoietic stem cell transplantation: Results of a 5-year survey.	28033514
Lymphoma, Relapsing course	Stem Cell Exhaustion	Relapsed or Refractory Double-Expressor and Double-Hit Lymphomas Have Inferior Progression-Free Survival After Autologous Stem-Cell Transplantation.	28034071
Mantle cell lymphoma	Stem Cell Exhaustion	Molecular Monitoring after Autologous Stem Cell Transplantation and Preemptive Rituximab Treatment of Molecular Relapse; Results from the Nordic Mantle Cell Lymphoma Studies (MCL2 and MCL3) with Median Follow-Up of 8.5 Years.	28039078
Lymphoma	Stem Cell Exhaustion	Among the patients enrolled in 2 prospective trials by the Nordic Lymphoma Group, 183 who had completed autologous stem cell transplantation (ASCT) and in whom an MRD marker had been obtained were included in our analysis.	28039078
Fatigue, Specialty Type - cancer	Stem Cell Exhaustion	Intensive cancer treatment followed by hematopoietic stem cell transplantation (HCT) results in moderate to severe fatigue and physical inactivity, leading to diminished functional ability.	28042020
Anterior Cruciate Ligament Injuries	Stem Cell Exhaustion	Viable stem cells are mobilized to the postinjury effusion at the time of cruciate ligament injury and can be found in the byproduct waste of cruciate ligament surgery.	28043750
RAB27A gene, Malignant neoplasm of ovary	Stem Cell Exhaustion	MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A.	28043921
Malignant neoplasm of ovary	Stem Cell Exhaustion	One of these miRNAs is miR-134-3p, and its expression changes significantly in human ovarian cancer stem cells (OCSCs) and in CD44-/CD133- ovarian cancer.	28043921
Gastrointestinal mucositis	Stem Cell Exhaustion	Topical Recombinant Human Epidermal Growth Factor for Oral Mucositis Induced by Intensive Chemotherapy with Hematopoietic Stem Cell Transplantation: Final Analysis of a Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial.	28045958
Gastrointestinal mucositis, Oman	Stem Cell Exhaustion	The aim of this study was to evaluate the efficacy and safety of recombinant human epidermal growth factor (rhEGF) oral spray for oral mucositis (OM) induced by intensive chemotherapy with hematopoietic stem cell transplantation.	28045958
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells (CSCs) are thought to be the "root" of cancer.	28046028
Specialty Type - cancer	Stem Cell Exhaustion	Assessments were made from the pretreatment phase of transplantation to after the end of parenteral nutrition in 51 patients who underwent allogeneic stem cell transplantation at Shizuoka Cancer Center between 2007 and 2012.	28050676
Weight decreased	Stem Cell Exhaustion	Early and customized nutritional intervention may be optimal for all patients who undergo allogeneic stem cell transplantation to ameliorate body weight loss associated with nutrition-related adverse events.	28050676
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation for multiple myeloma: Long-term results.	28050994
Polyneuropathy	Stem Cell Exhaustion	In vitro modelling of familial amyloidotic polyneuropathy allows quantitative detection of transthyretin amyloid fibril-like structures in hepatic derivatives of patient-specific induced pluripotent stem cells.	28051995
Leukemia, Myelocytic, Acute, Acute leukemia	Stem Cell Exhaustion	Impact of FAB classification on predicting outcome in acute myeloid leukemia, not otherwise specified, patients undergoing allogeneic stem cell transplantation in CR1: An analysis of 1690 patients from the acute leukemia working party of EBMT.	28052366
Leukemia, Myelocytic, Acute, NPM1 wt Allele	Stem Cell Exhaustion	While recent data proposes that FAB classification does not provide additional prognostic information for patients for whom NPM1 status is available, it is unknown whether FAB still retains a current prognostic role in predicting outcome of AML patients undergoing allogeneic stem cell transplantation.	28052366
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Relapse risk and survival in patients with FLT3 mutated acute myeloid leukemia undergoing stem cell transplantation.	28052408
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In patients with AML with FMS-like tyrosine kinase 3 (FLT3) mutations, the significance of minimal residual disease (MRD) detected by PCR before allogeneic stem cell transplantation (SCT) on outcomes after transplant remains unclear.	28052408
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease (GVHD) is the major treatment-related complication after stem-cell transplantation (SCT) from unrelated-donors.	28052467
Chronic heart failure	Stem Cell Exhaustion	Safety, feasibility and effectiveness of first in-human administration of muscle-derived stem/progenitor cells modified with connexin-43 gene for treatment of advanced chronic heart failure.	28052545
Heart failure	Stem Cell Exhaustion	To assess the safety and efficacy of transendocardial delivery of muscle-derived stem/progenitor cells with connexin-43 overexpression (Cx-43-MDS/PC) in advanced heart failure (HF).	28052545
Hematologic Neoplasms	Stem Cell Exhaustion	Patients ranged in age from 2 months to 71 years and 80% had hematologic malignancy or were bone marrow or hematopoietic stem cell transplant recipients.	28054734
PAFAH1B1 wt Allele, REG1CP gene	Stem Cell Exhaustion	Significant better RS was found for younger compared to older higher-risk MDS patients (48% vs. 17%), reflecting the effect of allogeneic hematopoietic stem-cell transplantation.	28056392
Sarcoma, Myeloid	Stem Cell Exhaustion	Clinical outcome of myeloid sarcoma in adult patients and effect of allogeneic stem cell transplantation.	28056398
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT).	28057639
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Outcome of allogeneic hematopoietic stem cell transplantation in adult patients with acute myeloid leukemia harboring trisomy 8.	28058493
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	However, the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) in adult patients with AML harboring +8 remains unclear.	28058493
Hematologic Neoplasms, Diabetes, Acute leukemia	Stem Cell Exhaustion	Maximum glucose was a predictor of hospital length of stay among patients without diabetes (but not those with diabetes), and with acute leukemia or stem cell transplant (but not other hematologic malignancies).	28058528
Hematologic Neoplasms, Diabetes	Stem Cell Exhaustion	Maximum glucose was a predictor of length of stay but this was only significant for patients without diabetes, those with acute hematologic malignancy or stem cell transplant.	28058528
spinal defect	Stem Cell Exhaustion	Omniscan (gadodiamide) magnetic resonance imaging tractography was analyzed to assess the spinal defects and the improvement by human embryonic stem cell treatment.	28058985
Spinal Cord Injuries	Stem Cell Exhaustion	Magnetic resonance imaging tractography as a diagnostic tool in patients with spinal cord injury treated with human embryonic stem cells.	28058985
Spinal Cord Diseases	Stem Cell Exhaustion	Spinal disorders have been treated with human embryonic stem cells.	28058985
Spinal Cord Injuries	Stem Cell Exhaustion	The present study was conducted to evaluate the diagnostic modality of magnetic resonance imaging tractography to determine the efficacy of human embryonic stem cells in chronic spinal cord injury.	28058985
Malignant neoplasm of liver	Stem Cell Exhaustion	Shp2 promotes liver cancer stem cell expansion by augmenting b-catenin signaling and predicts chemotherapeutic response of patients.	28059452
Specialty Type - cancer	Stem Cell Exhaustion	Src-homology 2 domain-containing phosphatase 2 (Shp2) has been reported to play an important role in the maintenance and self-renewal of embryonic and adult stem cells, but its role in cancer stem cells (CSCs) remains obscure.	28059452
Graft-vs-Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	To validate the International Chronic Ocular GVHD Consensus Group (ICCGVHD) diagnostic criteria for chronic ocular chronic graft-versus-host disease (GVHD), by comparing results with comprehensive ophthalmic evaluation after allogeneic hematopoietic stem cell transplantation.	28060078
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Increased Proangiogenic Activity of Mobilized CD34+ Progenitor Cells of Patients With Acute ST-Segment-Elevation Myocardial Infarction: Role of Differential MicroRNA-378 Expression.	28062497
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Proangiogenic effects of mobilized bone marrow-derived stem/progenitor cells are essential for cardiac repair after myocardial infarction.	28062497
Electrocardiogram: myocardial infarction (finding), Coronary Arteriosclerosis	Stem Cell Exhaustion	We investigated the differential regulation of angio-miRs, that is, miRNAs regulating neovascularization, in mobilized CD34+ progenitor cells obtained from patients with an acute ST-segment-elevation myocardial infarction (STEMI) as compared with those with stable coronary artery disease or healthy subjects.	28062497
Coronary Arteriosclerosis	Stem Cell Exhaustion	CD34+ progenitor cells were isolated from patients with STEMI (on day 0 and day 5), stable coronary artery disease, and healthy subjects (n=27).	28062497
Acute myocardial infarction	Stem Cell Exhaustion	The increased proangiogenic activity of these cells in patients with STEMI and the observation that in particular miR-378 regulates the angiogenic capacity of CD34+ progenitor cells in vivo suggest that this unique miRNA expression pattern represents a novel endogenous repair mechanism activated in acute myocardial infarction.	28062497
Comorbidity	Stem Cell Exhaustion	Outcome after allogeneic hematopoietic stem cell transplantation is influenced by patient comorbidity, disease type, and status before treatment.	28063962
Hematologic Neoplasms	Stem Cell Exhaustion	We performed a retrospective study involving 521 consecutive adult hematopoietic stem cell transplantation patients who underwent transplantation for hematological malignancy at our center from 2000 to 2012 to compare the predictive value of the hematopoietic cell transplantation-specific comorbidity index (HCT-CI) and the disease risk index (DRI) for overall survival and transplantation-related mortality.	28063962
Hepatitis B	Stem Cell Exhaustion	Impact of Hepatitis B Core Antibody Seropositivity on the Outcome of Autologous Hematopoietic Stem Cell Transplantation for Multiple Myeloma.	28063964
skeletal muscle cell proliferation	Stem Cell Exhaustion	Furthermore, Ang II inhibits skeletal muscle stem cell proliferation, leading to lowered muscle regenerative capacity.	28066057
Lymphoma	Stem Cell Exhaustion	In an otherwise eligible patient with relapsed lymphoma, inadequate mobilization of hematopoietic stem cells (HSCs) is a limiting factor to proceeding with an autologous hematopoietic cell transplantation (auto-HCT).	28067870
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The clinical outcome of primary refractory (PRF) AML patients is poor and only a minor proportion of patients is rescued by allogenic hematopoietic stem cell transplantation (HSCT).	28067875
Lymphoma	Stem Cell Exhaustion	Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma.	28068180
Therapy-related acute myeloid leukemia and myelodysplastic syndrome, Lymphoma, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We hypothesized that in patients undergoing autologous stem-cell transplantation (ASCT) for lymphoma, CHIP at the time of ASCT would be associated with an increased risk of myelodysplastic syndrome and acute myeloid leukemia, collectively termed therapy-related myeloid neoplasm (TMN), and other adverse outcomes.	28068180
Hodgkin Disease, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Methods We performed whole-exome sequencing on pre- and post-ASCT samples from 12 patients who developed TMN after autologous transplantation for Hodgkin lymphoma or non-Hodgkin lymphoma and targeted sequencing on cryopreserved aliquots of autologous stem-cell products from 401 patients who underwent ASCT for non-Hodgkin lymphoma between 2003 and 2010.	28068180
Keratitis, DLST wt Allele, Photophobia	Stem Cell Exhaustion	The first DLT, grade 3 photophobia, occurred at 4.34 mg/kg and two additional DLTs, grade 2 keratitis and grade 1 limbal stem cell deficiency (> 2-week dosing delay), at 6.5 mg/kg.	28070718
Pituitary Adenoma	Stem Cell Exhaustion	The histogenesis of the adipose element in pituitary adenoma is not well understood, and could be a result of a metaplastic change or divergent differentiation from a common progenitor cell.	28070930
Graft-vs-Host Disease, Communicable Diseases	Stem Cell Exhaustion	Infection, relapse, and GVHD can complicate allogeneic hematopoietic stem cell transplantation (allo-HSCT).	28073320
Lymphoma	Stem Cell Exhaustion	Safety and efficacy of allogeneic hematopoietic stem cell transplant after PD-1 blockade in relapsed/refractory lymphoma.	28073785
Mycosis Fungoides	Stem Cell Exhaustion	Donor-derived mycosis fungoides following reduced intensity haematopoietic stem cell transplantation from a matched unrelated donor.	28073814
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	A 46-year-old woman with a history of dasatinib-resistant chronic myeloid leukaemia, clonal evolution and monosomy 7 underwent reduced intensity conditioned in vivo T-cell-depleted allogeneic haematopoietic stem cell transplantation (HSCT) from a matched unrelated donor.	28073814
PAFAH1B1 wt Allele, Dysplasia, Cytopenia, Myeloid, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	The myelodysplastic syndrome (MDS) comprises a group of clonal hematopoietic stem cell diseases characterized by cytopenia, dysplasia in one or more of the major myeloid lineages, ineffective hematopoiesis, and increased risk of development of acute myeloid leukemia (AML).	28074192
Neoplasms	Stem Cell Exhaustion	We speculate that migration of defective neural crest stem cells along both upper limb buds during embryogenesis may have allowed these essentially identical tumors to arise in similar locations bilaterally simultaneously.	28075051
Malignant neoplasm of lung	Stem Cell Exhaustion	We demonstrate miR-410 increases the levels of stem cells marker Sox2, Oct4, Nanog, CXCR4 as well as lung cancer stem cells surface marker CD44 and CD166.	28076327
Secondary Neoplasm	Stem Cell Exhaustion	MiR-410 promotes stem cells-like properties such as proliferation, sphere formation, metastasis and chemoresistance.	28076327
Specialty Type - cancer	Stem Cell Exhaustion	We demonstrated that PDHA1 gene KO significantly decreased mitochondrial OXPHOS and promoted anaerobic glycolysis, accompanied with higher stemness phenotype including resistance to chemotherapy, enhanced migration ability and increased expression of cancer stem cell markers.	28076853
Lymphoma	Stem Cell Exhaustion	Few studies have assessed bone health in lymphoma survivors treated with high-dose therapy with autologous stem cell transplantation (HDT-ASCT).	28077016
Febrile Neutropenia, Malignant Neoplasms	Stem Cell Exhaustion	Patients were >18 years old with febrile neutropenia (neutrophil count <500 cells/mm3 and temperature >38.0oC) and received chemotherapy or stem cell transplant as treatment for malignancy.	28077047
Respiratory Syncytial Virus Infections, Allogeneic Hematopoietic Stem Cell Transplant Recipient	Stem Cell Exhaustion	Effective use of oral ribavirin for respiratory syncytial viral infections in allogeneic haematopoietic stem cell transplant recipients.	28077243
Viral respiratory infection	Stem Cell Exhaustion	Respiratory syncytial virus (RSV) is a frequent cause of respiratory viral infections, increasing the morbidity and mortality in allogeneic haematopoietic stem cell transplantation (HSCT) recipients.	28077243
Pituitary Adenoma	Stem Cell Exhaustion	In this sense, it is proposed that stem cell could be involved in pituitary adenoma tumorigenesis.	28078618
Blast Injuries	Stem Cell Exhaustion	Traumatized muscle, such as that debrided from blast injury sites, is considered a promising and convenient tissue source for multipotent progenitor cells (MPCs), a population of adult mesenchymal stem cell (MSC)-like cells.	28078807
Fabry Disease	Stem Cell Exhaustion	Energy utilization of induced pluripotent stem cell-derived cardiomyocyte in Fabry disease.	28082092
Cardiomyopathies, Fabry Disease, Dysautonomia, Familial	Stem Cell Exhaustion	We aimed to generate patient-specific induced pluripotent stem cells (iPSC) from FD patients presenting cardiomyopathy to determine whether the model could recapitulate key features of the disease phenotype and to investigate the energy metabolism in Fabry disease.	28082092
Prostate carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Co-Expression of Putative Cancer Stem Cell Markers CD44 and CD133 in Prostate Carcinomas.	28083789
Specialty Type - cancer, Secondary Neoplasm, Neoplastic Cell Transformation	Stem Cell Exhaustion	Cancer stem cells (CSCs) are the main players of prostate tumorigenesis thus; characterization of CSCs can pave the way for understanding the early detection, drug resistance, metastasis and relapse.	28083789
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	Stem-like subpopulations of cancer cells show high migratory and metastatic capacity, thus we hypothesize that breast cancer stem cell markers evaluation in metastasized lymph nodes could provide a more accurate prediction of patient's prognosis.	28084338
Childhood Breast Carcinoma, Neoplasms	Stem Cell Exhaustion	Therefore, the expression profile of P-cadherin, CD44, and CD49f, which have been already associated to stem cell properties in breast cancer, has been evaluated by immunohistochemistry in a series of 135 primary tumors and matched axillary lymph node metastases from 135 breast cancer patients.	28084338
FLT3 Internal Tandem Duplication	Stem Cell Exhaustion	Our data identified that old age, pre-HCT markers for MRD, and high post-HCT WT1, high dose of CD34+ stem cell (>=4.5 x 106/kg) infusion, and c-kit or FLT3-ITD mutations were associated with higher relapse rate and poor DFS.	28089879
Infectious Lung Disorder	Stem Cell Exhaustion	Suspected Pulmonary Infection with Trichoderma longibrachiatum after Allogeneic Stem Cell Transplantation.	28090056
Aplastic Anemia, Infectious Lung Disorder	Stem Cell Exhaustion	We herein report a case of isolated suspected invasive pulmonary infection with T. longibrachiatum in a 29-year-old man with severe aplastic anemia who underwent allogeneic stem cell transplantation.	28090056
Secondary malignant neoplasm of liver, Portal vein structure	Stem Cell Exhaustion	Portal Vein Embolization with Contralateral Application of Stem Cells Facilitates Increase of Future Liver Remnant Volume in Patients with Liver Metastases.	28091729
Secondary malignant neoplasm of liver	Stem Cell Exhaustion	This study aimed to evaluate the progress of future liver remnant volume (FLRV) in patients with liver metastases after portal vein embolization (PVE) with the application of hematopoietic stem cells (HSCs) and compare it with a patients control group after PVE only.	28091729
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	We investigated the use of haploidentical hematopoietic stem cell transplantation (haplo-HSCT) in the treatment of advanced Hodgkin lymphoma (HL).	28092347
Nephrotoxic	Stem Cell Exhaustion	Calcineurin inhibitor (CNI)-sparing T-cell depleted (TCD) hematopoietic stem cell transplants (HSCTs) are presumed to be less nephrotoxic than conventional HSCTs.	28092350
Hepatic Veno-Occlusive Disease, leukemia	Stem Cell Exhaustion	Risk of sinusoidal obstruction syndrome in allogeneic stem cell transplantation after prior gemtuzumab ozogamicin treatment: a retrospective study from the Acute Leukemia Working Party of the EBMT.	28092357
Hepatic Veno-Occlusive Disease, Spondylo-ocular syndrome	Stem Cell Exhaustion	Gemtuzumab ozogamicin (GO) may increase the risk of sinusoidal obstruction syndrome (SOS) when used prior to allogeneic stem cell transplantation (HSCT).	28092357
Specialty Type - cancer	Stem Cell Exhaustion	In addition, enforced expression of miR-215 suppressed the cancer stem cell signature through downregulation of intestinal stem cell markers including Lgr5.	28092415
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Tumor stem cells with self-renewal and multipotent capacity play critical roles in the initiation and progression of cancer.	28092415
Ischemic stroke	Stem Cell Exhaustion	Changes in serum vascular endothelial growth factor and endostatin concentrations associated with circulating endothelial progenitor cells after acute ischemic stroke.	28093678
Chemical injury	Stem Cell Exhaustion	Circulating endothelial progenitor cells (EPCs) also play an important role as an endogenous repair mechanism for ischemic injury.	28093678
Extrapulmonary Small Cell Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	When siRNA was used to knockdown Numb in ESCC cell lines, there was a consistent increase in caspase-3 dependent apoptosis and inhibition of cellular proliferation, as well as downregulation of expression of the cancer stem cell markers Oct-4, SOX-2 and Nanog.	28095111
Infection	Stem Cell Exhaustion	After allogeneic hematopoietic stem cell transplantation (HSCT), recovery of humoral immunity is essential to protect from life-threatening infections.	28095438
Musculoskeletal Diseases	Stem Cell Exhaustion	Stem cell-based therapies are being considered for the treatment of musculoskeletal diseases, but the presence of these inflammatory cytokines will have similar deleterious action on therapeutic cells delivered to these environments.	28095751
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	CD25 has been reported to be highly expressed in leukemia stem cells and correlated with adverse outcomes in young patients with acute myeloid leukemia (AML).	28097942
Dysautonomia, Familial	Stem Cell Exhaustion	Given the systemic nature of enzyme deficiency, we hypothesized that the stem cell compartment of GD and FD patients might be also affected.	28098348
Lysosomal Storage Diseases	Stem Cell Exhaustion	Impact of lysosomal storage disorders on biology of mesenchymal stem cells: Evidences from in vitro silencing of glucocerebrosidase (GBA) and alpha-galactosidase A (GLA) enzymes.	28098348
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic stem cell transplantation in adult patients with acute myeloid leukaemia and 17p abnormalities in first complete remission: a study from the Acute Leukemia Working Party (ALWP) of the European Society for Blood and Marrow Transplantation (EBMT).	28100265
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukaemia (AML) with 17p abnormalities (abn(17p)) carries a very poor prognosis due to high refractoriness to conventional chemotherapy, and allogeneic stem cell transplantation (allo-SCT) appears as the only potential curative option.	28100265
Depression, CTCAE	Stem Cell Exhaustion	Impact of pre-transplant depression on outcomes of allogeneic and autologous hematopoietic stem cell transplantation.	28102896
Acute leukemia	Stem Cell Exhaustion	A comparison between allogeneic stem cell transplantation from unmanipulated haploidentical and unrelated donors in acute leukemia.	28103944
Acute leukemia	Stem Cell Exhaustion	In the absence of a HLA-matched related or matched unrelated donor, allogeneic stem cell transplantation (allo-SCT) from mismatched unrelated donors or haploidentical donors are potential alternatives for patients with acute leukemia with an indication to allo-SCT.	28103944
Multiple Myeloma	Stem Cell Exhaustion	Efficacy and safety of high-dose chemotherapy with autologous stem cell transplantation in senior versus younger adults with newly diagnosed multiple myeloma.	28105753
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We retrospectively studied 340 fit patients with multiple myeloma (MM) who underwent autologous stem cell transplantation (ASCT).	28105753
Esophageal Small Cell Carcinoma	Stem Cell Exhaustion	In addition, SOX2 overexpression observed in esophageal and lung small-cell carcinoma as well as in the embryonic esophagus indicated that esophageal small-cell carcinoma may arise from embryonic-like stem cells in the esophageal epithelium.	28106103
Esophageal Small Cell Carcinoma	Stem Cell Exhaustion	The two distinct differentiation patterns (neuroendocrine and glandular) of esophageal small-cell carcinoma further support the fact that SOX2 has a pivotal role in the differentiation of pluripotent stem cells into esophageal small-cell carcinoma cells.	28106103
Malignant Neoplasms	Stem Cell Exhaustion	Aldehyde dehydrogenase 1 (ALDH1) has been proposed as biomarker of stem cells for certain human cancers.	28106104
Multiple Myeloma	Stem Cell Exhaustion	Chorioretinal folds in a patient with multiple myeloma treated with stem cell transplant.	28106236
Multiple Myeloma	Stem Cell Exhaustion	Subsequently, she was treated with stem cell transplant for myeloma, which resulted in remission of her disease.	28106236
Cerebral Palsy	Stem Cell Exhaustion	Neuroregenerative potential of intravenous G-CSF and autologous peripheral blood stem cells in children with cerebral palsy: a randomized, double-blind, cross-over study.	28109298
Multiple Myeloma	Stem Cell Exhaustion	Bortezomib and thalidomide maintenance after stem cell transplantation for multiple myeloma: a PETHEMA/GEM trial.	28111466
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The phase III trial GEM05MENOS65 randomized 390 patients 65 years old or younger with newly diagnosed symptomatic multiple myeloma (MM) to receive induction with thalidomide/dexamethasone, bortezomib/thalidomide/dexamethasone and Vincristine, BCNU, melphalan, cyclophosphamide, prednisone/vincristine, BCNU, doxorubicin, dexamethasone bortezomib (VBMCP/VBAD/B) followed by autologous stem cell transplantation (ASCT) with MEL-200.	28111466
Clear cell adenocarcinoma of ovary, Specialty Type - cancer	Stem Cell Exhaustion	Low uptake of fluorodeoxyglucose in positron emission tomography/computed tomography in ovarian clear cell carcinoma may reflect glutaminolysis of its cancer stem cell-like properties.	28112360
Specialty Type - cancer	Stem Cell Exhaustion	We obtained cancer stem cell (CSC)-like properties from CCC cell lines, and compared the expression levels of transporters between non-CSCs and CSCs.	28112360
Specialty Type - cancer	Stem Cell Exhaustion	MicroRNA (miR)-145 has been reported to induce cancer stem cell (CSC) differentiation through down-regulation of the stem cell transcription factors (TFs) that maintain CSC pluripotency.	28112371
Malignant tumor of cervix	Stem Cell Exhaustion	MicroRNA-145 inhibits tumorigenesis and invasion of cervical cancer stem cells.	28112371
Malignant tumor of cervix, Specialty Type - cancer	Stem Cell Exhaustion	High expression of miR-145 indicates a good prognosis in cancer patients, but its role in cervical cancer stem cells (CCSCs) is not known.	28112371
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	For young patients with high-risk CLL, BTK-/PI3K-inhibitors or allogeneic stem cell transplantation (alloHCT) are considered.	28112746
Specialty Type - cancer, Aggressive behavior, Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSCs), a subset of tumor cells, contribute to an aggressive biological behavior, which is also affected by the tumor stroma.	28114366
Degenerative polyarthritis	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) are promising candidates as a cell-based therapy for osteoarthritis (OA), although current results are modest.	28114800
Cyclic neutropenia	Stem Cell Exhaustion	Episodes of BSI due to ESBL-GNB occurring in haematological patients and haematopoietic stem cell transplant recipients with neutropaenia from 1 January 2006 to 31 March 2015 will be analysed.	28115333
Candidemia	Stem Cell Exhaustion	Clinical and Microbiological Characteristics of Breakthrough Candidemia in Allogeneic Hematopoietic Stem Cell Transplant Recipients in a Japanese Hospital.	28115352
Candidemia	Stem Cell Exhaustion	Few data on breakthrough candidemia (BC), defined as candidemia that develops on administration of antifungal agents (AFAs), in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients are available.	28115352
Burn, CTCAE	Stem Cell Exhaustion	This work aims to standardize the isolation of amniotic stem cells and the selection of the optimal time of transplantation and cell application methods in burn patients according to the guidelines of the Good Manufacturing Practice.	28117628
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Impact of in vivo T cell depletion in HLA-identical allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission conditioned with a fludarabine iv-busulfan myeloablative regimen: a report from the EBMT Acute Leukemia Working Party.	28118857
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We retrospectively analyzed 566 patients who underwent a first HLA-identical allogeneic stem cell transplantation with this conditioning regimen for acute myeloid leukemia in first complete remission between 2006 and 2013 and compared the outcomes of 145 (25.6%) patients who received ATG (ATG group) to 421 (74.4%) who did not (no-ATG group).	28118857
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	These results suggest that the use of ATG with fludarabine and 4 days intravenous busulfan followed by HLA-identical sibling donor allogeneic stem cell transplantation for acute myeloid leukemia improves overall transplant outcomes due to reduced incidence of chronic GVHD without increased relapse risk.	28118857
Acute leukemia	Stem Cell Exhaustion	Impact of recommended weight-based dosing of granulocyte-colony stimulating factors in acute leukemia and stem cell transplant patients.	28120115
Acute leukemia	Stem Cell Exhaustion	A retrospective chart review of patients with acute leukemia or stem cell transplant recipients who received G-CSF from May 2009 to September 2015 was conducted.	28120115
Hematopoietic	Stem Cell Exhaustion	Mice homozygous for a null Brca1 mutation in the embryonic hematopoietic system (Vav1-iCre;Brca1F22-24/F22-24) developed hematopoietic defects in early adulthood that included reduced hematopoietic stem cells (HSCs).	28122244
Hematopoietic stem cells, Hematopoietic	Stem Cell Exhaustion	Although mice homozygous for a huBRCA1 knockin allele (Brca1BRCA1/BRCA1) were normal, mice with a mutant huBRCA1/5382insC allele and a null allele (Mx1-Cre;Brca1F22-24/5382insC) had severe hematopoietic defects marked by a complete loss of hematopoietic stem and progenitor cells.	28122244
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	We find that GBM induced in neural stem-cell-like glial fibrillary acidic protein (GFAP)-expressing cells in the subventricular zone of adult mice shows accelerated tumor development and produces more malignant GCs (mGC1GFAP) that are less resistant to cancer drugs, compared with those originating from more differentiated nestin- (mGC2NES) or 2,'3'-cyclic nucleotide 3'-phosphodiesterase (mGC3CNP)-expressing cells.	28122246
Carcinoma	Stem Cell Exhaustion	Integrative genomic analysis of HCC-CCAs revealed that cholangiolocellular carcinoma (CLC) represents a distinct biliary-derived entity compared with the stem-cell and classical types.	28126467
Neoplasms	Stem Cell Exhaustion	Stem-cell tumors were characterized by spalt-like transcription factor 4 (SALL4) positivity (6/8 vs. 0/10, p<0.001), enrichment of progenitor-like signatures, activation of specific oncogenic pathways (i.e., MYC and insulin-like growth factor [IGF]), and signatures related to poor clinical outcome.	28126467
Neoplasms, Hollings Cancer Center	Stem Cell Exhaustion	Mixed HCC-CCA represents a heterogeneous group of tumors, with the stem-cell type characterized by features of poor prognosis, and the classical type with common lineage for HCC and iCCA components.	28126467
Intrahepatic Route of Drug Administration, Neoplasms, Hollings Cancer Center	Stem Cell Exhaustion	However, within mixed HCC-CCA, stem-cell type tumors shared an aggressive nature and poor outcome, whereas the classic type showed a common cell lineage for both the HCC and the intrahepatic CCA component.	28126467
Multiple Myeloma	Stem Cell Exhaustion	Recovery of polyclonal immunoglobulins one year after autologous stem cell transplantation as a long-term predictor marker of progression and survival in multiple myeloma.	28126960
Atrial Fibrillation by ECG Finding	Stem Cell Exhaustion	Permanent atrial fibrillation impairs the function of circulating endothelial progenitor cells.	28128678
Atrial Fibrillation by ECG Finding	Stem Cell Exhaustion	to determine whether functions of endothelial progenitor cells (EPCs) were impaired in patients with permanent atrial fibrillation (AF).	28128678
Doctor of Chiropractic, Dilated Cardiomyopathy Pathway	Stem Cell Exhaustion	Here, we show that treatment of human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) and neonatal rat ventricular myocytes (NRVMs) with serum from pediatric dilated cardiomyopathy (DCM) patients induces pathological changes in gene expression, which occur independently of the RAAS and adrenergic systems, suggesting that serum circulating factors play an important role in cardiac remodeling.	28130338
Graft-vs-Host Disease, Myeloid neoplasm	Stem Cell Exhaustion	We conducted a pilot study on the feasibility of CD56-enriched donor cell infusion after post-transplantation cyclophosphamide (PTCy) for 10 patients with advanced myeloid malignancies undergoing haploidentical peripheral blood stem cell transplantation with cyclosporine alone as graft-versus-host disease (GVHD) prophylaxis and compared the outcome and immune reconstitution with a control group of 20 patients undergoing the same without CD56-enriched donor cell infusion.	28131632
methyldopa	Stem Cell Exhaustion	We report the derivation of human-induced pluripotent stem cells (hiPSCs) from patients with diagnosed AMD, including two donors with the rare ARMS2/HTRA1 homozygous genotype.	28132833
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Prognostic impact of the CD34+/CD38- cell burden in patients with acute myeloid leukemia receiving allogeneic stem cell transplantation.	28133783
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Here we evaluated clinical and biological associations and the prognostic impact of a high diagnostic CD34+/CD38- cell burden in 169 AML patients receiving an allogeneic stem cell transplantation in complete remission.	28133783
Toxic nephropathy	Stem Cell Exhaustion	Allogeneic hemopoietic stem cell transplantation (allo-HSCT) poses a significant challenge to renal function due to multiple drug- and complication-related renal toxicity.	28135776
Dementia, Vascular	Stem Cell Exhaustion	Umbilical cord-derived mesenchymal stem cell transplantation for treating elderly vascular dementia.	28138805
VAD I protocol, Dementia, Vascular	Stem Cell Exhaustion	This study aimed to determine the efficacy and safety of human umbilical cord-derived mesenchymal stem cell (HUC-MSC) transplantation for treating elderly vascular dementia (VaD).	28138805
Cerebrovascular accident	Stem Cell Exhaustion	Attitudes to Stem Cell Therapy Among Ischemic Stroke Survivors in the Lund Stroke Recovery Study.	28142330
Multiple Myeloma	Stem Cell Exhaustion	Polymorphism in ANRIL is associated with relapse in patients with multiple myeloma after autologous stem cell transplant.	28150872
Aplastic Anemia, Dry cough	Stem Cell Exhaustion	A 23-year-old man who had previously undergone allogeneic hematopoietic stem cell transplantation (allo-HSCT) for severe aplastic anemia was diagnosed with invasive laryngeal-tracheobronchial-pulmonary aspergillosis after presenting with a persistent dry cough at six months post-transplantation based on the findings of laryngoscopy and fiberoptic bronchoscopy.	28154281
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	BACKGROUND Acute graft-versus-host disease (aGVHD) remains the most common and challenging complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT).	28154370
Icterus	Stem Cell Exhaustion	In this study, we transplanted human neural progenitor cells differentiated toward propriospinal interneurons into the striatum of 20-day-old spontaneously jaundiced (jj) Gunn rats and nonjaundiced (Nj) littermates.	28155818
Malignant Neoplasms	Stem Cell Exhaustion	Zinc finger protein X-linked (ZFX) is frequently upregulated in multiple human malignancies and also plays a critical role in the maintenance of self-renewal in embryonic stem cells.	28156061
Malignant neoplasm of liver	Stem Cell Exhaustion	However, the role of ZFX in liver cancer stem cells (CSCs) remains obscure.	28156061
Cessation of life	Stem Cell Exhaustion	Treatment, when reported (n = 136), included explantation [n = 125 (91.9 percent)], chemotherapy [n = 42 (30.8 percent)], radiation therapy [n = 25 (18.4 percent)], and/or stem cell transplant [n = 9 (6.6 percent)], and five deaths were reported.	28157770
Prediabetes syndrome, Neurologic Deficits	Stem Cell Exhaustion	Therefore, we tested the hypothesis that metformin, an AMPK activator, protects against diabetic AGE induced neuronal impairment in human neural stem cells (hNSCs).	28159472
Hemorrhagic cystitis	Stem Cell Exhaustion	Nationwide survey of BK polyomavirus associated hemorrhagic cystitis in adult allogeneic stem cell transplantation among haematologists and urologists.	28160087
Hemorrhagic cystitis	Stem Cell Exhaustion	There are no epidemiological data on BK virus associated hemorrhagic cystitis (BKHC) in adult allogeneic stem cell transplantation in Germany available and associations with clinical conditions like GvHD are controversially discussed.	28160087
Toxic effect, Gastrointestinal mucositis, Multiple Myeloma	Stem Cell Exhaustion	High-dose melphalan followed by autologous stem cell transplantation remains the standard of care for eligible patients with multiple myeloma, but disease response and toxicity, including severe mucositis, varies among patients.	28160288
diabetic	Stem Cell Exhaustion	p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo.	28163043
Diabetes Mellitus	Stem Cell Exhaustion	Therefore our results provide a support for bFGF as a potential therapeutic agent for improving stem cell-based approaches for the treatment of diabetes mellitus and its complications.	28168007
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation for non-Hodgkin's lymphomas: a retrospective analysis of 77 cases.	28168350
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (allo-SCT) is a therapeutic option for relapsed, advanced, and otherwise incurable non-Hodgkin's lymphomas (NHL) suggested by the existence of a graft-versus-lymphoma effect.	28168350
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	4 PATIENT: A 59-year-old man underwent stem cell transplantation for acute myeloid leukemia.	28168387
Specialty Type - cancer	Stem Cell Exhaustion	Cancer cells use alternate energetic pathways; however, cancer stem cell (CSC) metabolic energetic pathways are unknown.	28168879
Aplastic Anemia	Stem Cell Exhaustion	Allogeneic haematopoietic stem cell transplantation is curative for severe aplastic anaemia (SAA) unresponsive to immunosuppressive therapy.	28169418
Graft-vs-Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	To reduce chronic graft-versus-host disease (GVHD), which occurs more frequently after peripheral blood stem cell (PBSC) transplantation compared to bone-marrow transplantation (BMT), and to prevent graft rejection, we developed a novel partial T-cell depleted transplant that infuses high numbers of granulocyte colony-stimulating factor-mobilized CD34+ selected PBSCs combined with a BMT-equivalent dose of non-mobilized donor T-cells.	28169418
Aplastic Anemia	Stem Cell Exhaustion	Allogeneic transplantation using CD34+ selected peripheral blood progenitor cells combined with non-mobilized donor T cells for refractory severe aplastic anaemia.	28169418
Lupus Erythematosus	Stem Cell Exhaustion	JAK-STAT signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients.	28177455
Lupus Erythematosus, Encephalitis, St. Louis	Stem Cell Exhaustion	Previous studies have revealed that bone marrow-mesenchymal stem cells (BM-MSCs) from systemic lupus erythematosus (SLE) patients exhibited early signs of senescence, which may participate in the development of SLE.	28177455
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Prognostic Mutations in Myelodysplastic Syndrome after Stem-Cell Transplantation.	28177873
PAFAH1B1 wt Allele	Stem Cell Exhaustion	Genetic profiling revealed that molecular subgroups of patients undergoing allogeneic hematopoietic stem-cell transplantation for MDS may inform prognostic stratification and the selection of conditioning regimen.	28177873
Keratopathy	Stem Cell Exhaustion	On her last follow-up 14 years after PK in 2016, her vision in the left eye was 20/40 with lipid keratopathy and her right eye showed no signs of focal limbal stem cell deficiency.	28179383
Specialty Type - cancer, Neoplasms, Central neuroblastoma	Stem Cell Exhaustion	These findings suggest the possibility of developing novel therapeutic strategies against PNETs by targeting DCLK1.Implications: Evidence here reveals that human PNETs diffusely and robustly express the cancer stem cell marker DCLK1, which drives SLUG-mediated EMT, and suggests that NETs share biological features for druggable targets with other tumors, including neuroblastoma that also highly expresses DCLK1.	28179411
Neuroblastoma, Pancreatic carcinoma	Stem Cell Exhaustion	Doublecortin-like kinase 1 (DCLK1), a marker for intestinal and pancreatic cancer stem cells, is highly expressed in neuroblastomas.	28179411
Fatigue	Stem Cell Exhaustion	On univariate analysis fatigue, QOL, physician-reported performance status, autologous stem cell transplant (ASCT), and Mayo stage were prognostic for survival.	28181278
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Patient age and number of apheresis days may predict development of secondary myelodysplastic syndrome and acute myelogenous leukemia after high-dose chemotherapy and autologous stem cell transplantation for lymphoma.	28185276
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	The goal of our study was to find predictors for the development of secondary myelodysplastic syndrome or acute myelogenous leukemia (s-MDS/AML) in patients with relapsed or refractory lymphoma who received high-dose chemotherapy and autologous stem cell transplantation (ASCT).	28185276
Lymphoma	Stem Cell Exhaustion	We conducted a retrospective review of 295 patients with relapsed or refractory lymphoma who had undergone their first stem cell collection and ASCT.	28185276
Spinal Cord Injuries	Stem Cell Exhaustion	Clinical Study of NeuroRegen Scaffold Combined With Human Mesenchymal Stem Cells for the Repair of Chronic Complete Spinal Cord Injury.	28185615
Stanford Cancer Institute	Stem Cell Exhaustion	In this study, eight patients with chronic complete SCI were enrolled to examine the safety and efficacy of implanting NeuroRegen scaffold with human umbilical cord mesenchymal stem cells (hUCB-MSCs).	28185615
Malignant neoplasm of liver	Stem Cell Exhaustion	In this study, we investigated the functional role of HBx-DC1 in regulating liver cancer stem cell (CSC) properties.	28186991
Injury of liver	Stem Cell Exhaustion	Using a murine model of liver injury, we previously identified the importance of canonical Hh signaling within the Pc+ liver progenitor cell (LPC) population and noted that SMO-independent, GLI-mediated signals were important in multiple Pc-ve GLI2+ intrahepatic populations.	28187190
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	In addition, the regenerative potential of purified stem cells was assessed 3 weeks after transplantation in immunodeficient mice which had been subjected to experimental myocardial infarction.	28187777
Adult Glioblastoma	Stem Cell Exhaustion	High-dose Neural Stem Cell Radiation May Not Improve Survival in Glioblastoma.	28188088
Adult Glioblastoma, Chemoradiotherapy	Stem Cell Exhaustion	To evaluate the effect of radiotherapy dose-volume parameters of neural stem cell (NSC) compartment on progression-free survival (PFS) and overall survival after post-resection chemoradiation in newly diagnosed glioblastoma.	28188088
Cessation of life, Ann Arbor Stage I Nasal Type NK/T-Cell Lymphoma	Stem Cell Exhaustion	Seven male patients with NK/T-cell lymphoma (median age, 49 years; range, 31-68 years) for whom a median of 2 (range, 1-5) regimens (including l-asparaginase regimens and allogeneic hematopoietic stem-cell transplantation [HSCT] in 2 cases) failed were treated with the anti-programmed death 1 (PD1) antibody pembrolizumab.	28188133
Specialty Type - cancer	Stem Cell Exhaustion	Stem Cell Reviews and Reports: Cancer Stem Cells and Aging Section.	28188496
Malignant Neoplasms	Stem Cell Exhaustion	Sex-determining region Y-box 2 (SOX2) is an essential factor involved in the self-renewal and pluripotency of embryonic stem cells and has functions in cell survival and progression in many types of cancers.	28188685
leukemia	Stem Cell Exhaustion	Decitabine before Low-Dose Cytarabine-Based Chemotherapy Combined with Human Leukocyte Antigen-Mismatched Stem Cell Microtransplantation Improved Outcomes in Elderly Patients with Newly Diagnosed Acute Myeloid Leukemia.	28189902
Graft-vs-Host Disease, Toxic effect, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We conducted a prospective study of 23 elderly patients (median age, 68 years; range, 60 to 87 years) with newly diagnosed AML to evaluate the efficacy and toxicity of decitabine plus granulocyte colony-stimulating factor priming, low-dose aclarubicin, and cytarabine (DCAG) chemotherapy combined with HLA-mismatched stem cell microtransplantation (SC-MST) without graft-versus-host disease (GVHD) prophylaxis.	28189902
Neoplasms, Carcinogenesis	Stem Cell Exhaustion	Expression of the stem cell marker CD133 is related to tumor development in colorectal carcinogenesis.	28190751
Colorectal Carcinoma	Stem Cell Exhaustion	CD133 is currently considered the most robust surface marker for colorectal cancer stem cells.	28190751
Doctor of Chiropractic, Dilated Cardiomyopathy Pathway	Stem Cell Exhaustion	Stem cell therapy has shown therapeutic benefit in dilated cardiomyopathy (DCM), but doubt remains about the most appropriate stem cell subpopulation.	28190794
Doctor of Chiropractic	Stem Cell Exhaustion	There were no differences in MACE among the 3 groups (P = 0.817).Intracoronary bone marrow stem cell transplantation in DCM is safe and effective, while BMSC and BMMC infusion possess comparable effectiveness.	28190794
Dilated Cardiomyopathy Pathway	Stem Cell Exhaustion	A Randomized Comparative Study on the Efficacy of Intracoronary Infusion of Autologous Bone Marrow Mononuclear Cells and Mesenchymal Stem Cells in Patients With Dilated Cardiomyopathy.	28190794
Doctor of Chiropractic	Stem Cell Exhaustion	The current study compared the efficacy of intracoronary administration of bone marrow mononuclear cells (BMMC) or mesenchymal stem cells (BMSC) in patients with DCM.Fifty-three patients with DCM and reduced (< 40%) left ventricular ejection fraction (LVEF), were randomized to intracoronary infusion of BMMC (BMMC group, n = 16) or BMSC (BMSC group, n = 17) or equal volume normal saline (CTRL group, n = 20).	28190794
Benign prostatic hypertrophy	Stem Cell Exhaustion	Aberrant Transforming Growth Factor-b Activation Recruits Mesenchymal Stem Cells During Prostatic Hyperplasia.	28191756
Benign prostatic hypertrophy	Stem Cell Exhaustion	In this study, we show that aberrant activation of transforming growth factor-b (TGF-b) mobilizes mesenchymal/stromal stem cells (MSCs) in circulating blood, which are recruited for the prostatic stromal hyperplasia.	28191756
Osteosarcoma	Stem Cell Exhaustion	Generation of Osteosarcomas from a Combination of Rb Silencing and c-Myc Overexpression in Human Mesenchymal Stem Cells.	28191765
Play	Stem Cell Exhaustion	Suppression of Transforming Growth Factor-b Signaling Delays Cellular Senescence and Preserves the Function of Endothelial Cells Derived from Human Pluripotent Stem Cells.	28191769
Vascular Diseases	Stem Cell Exhaustion	Transplantation of vascular cells derived from human pluripotent stem cells (hPSCs) offers an attractive noninvasive method for repairing the ischemic tissues and for preventing the progression of vascular diseases.	28191769
Neurotoxicity Syndromes	Stem Cell Exhaustion	The neurons derived for the human induced pluripotent stem cells (hiPSCs) provide a relevant and powerful tool for the research in pharmaceutical and environmental neurotoxicity.	28193519
Nerve Degeneration	Stem Cell Exhaustion	In this study, we for the first time used human induced pluripotent stem cells (hiPSCs)-derived neurons (iCell neurons) to investigate the mechanisms of TD-induced neurodegeneration.	28193519
Specialty Type - cancer	Stem Cell Exhaustion	Recently, it was suggested that tissue variation in cancer risk originates from differences in the number of stem-cell divisions underlying each tissue, leading to different mutation loads.	28193856
Secondary Neoplasm, Esophageal Neoplasms	Stem Cell Exhaustion	Stem cell autocrine CXCL12/CXCR4 stimulates invasion and metastasis of esophageal cancer.	28193907
Neoplasms, Secondary Neoplasm, Esophageal Neoplasms	Stem Cell Exhaustion	Esophageal cancer stem cells are considered the source for recurrence and metastasis of the tumors.	28193907
Esophageal Neoplasms	Stem Cell Exhaustion	This study found that esophageal cancer stem cells not only autocrine a great amount of CXCL12, but also high expression of its corresponding receptor CXCR4.	28193907
Esophageal Neoplasms	Stem Cell Exhaustion	Most importantly, the ability of esophageal cancer stem cells to spread and metastasize could be inhibited by blockage of CXCR4 with inhibitors or shRNA approaches both in vivo and in vitro studies.	28193907
Secondary Neoplasm, Esophageal Neoplasms	Stem Cell Exhaustion	The important role of CXCL12 in the invasion and metastasis of esophageal cancer stem cells was also confirmed by loss-of-function and gain-of-function strategies.	28193907
Secondary Neoplasm, Esophageal Neoplasms	Stem Cell Exhaustion	Mechanistically, we demonstrated that CXCL12/CXCR4 activated the ERK1/2 pathway and thereby ultimately maintained the characteristics of high-level invasion and metastasis of esophageal cancer stem cells.	28193907
Esophageal Neoplasms	Stem Cell Exhaustion	Taken together, our findings suggested that autocrine CXCL12/CXCR4 was one of the major mechanisms underlying the metastatic property of esophageal cancer stem cells through ERK1/2 signaling pathway, and might serve as a therapeutic target for esophageal cancer patients.	28193907
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Inhibition of serotonin receptor type 1 in acute myeloid leukemia impairs leukemia stem cell functionality: a promising novel therapeutic target.	28193998
Neoplasms, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukemia (AML) is a clinically and molecularly heterogeneous neoplasia with poor outcome, organized as a hierarchy initiated and maintained by a sub-population with differentiation and self-renewal capacities called leukemia stem cells (LSCs).	28193998
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Hematopoietic stem cell remobilization with vinorelbine and filgrastim in AML.	28194031
Ataxia, Spinocerebellar	Stem Cell Exhaustion	Treatment of Spinocerebellar Ataxia With Mesenchymal Stem Cells: A Phase I/IIa Clinical Study.	28195034
Neurodegenerative Disorders	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) have shown promise in treating neurodegenerative diseases.	28195034
Specialty Type - cancer	Stem Cell Exhaustion	All three models demonstrate substantial variation in cancer risks, by at least 20 orders of magnitude, depending on the assumed number of critical mutations required for cancer, and the stem-cell and transition-cell mutation rates.	28196079
Malignant Neoplasms	Stem Cell Exhaustion	However, for cancers with 2 or 3 critical mutations, a substantial proportion of cancers, in some cases 100%, have at least one mutation derived from a mutated stem cell.	28196079
Specialty Type - cancer	Stem Cell Exhaustion	The probability of a cancer being mutagen-induced correlates across cancer sites with the estimated cumulative number of stem cell divisions in the associated tissue (p<0.05), although in some cases there is sensitivity of findings to removal of high-leverage outliers and in some cases only modest variation in probability, but these issues do not affect the validity of the findings.	28196079
Specialty Type - cancer	Stem Cell Exhaustion	Cairns suggested that renewing tissues may reduce cancer risk by partitioning the dividing cell populations into lineages comprising infrequently-dividing long-lived stem cells and frequently-dividing short-lived daughter transit cells.	28196079
Malignant Neoplasms	Stem Cell Exhaustion	Very few cancers, generally <0.5%, arise from mutations occurring solely in stem cells rather than in a combination of stem and transit cells.	28196079
Malignant Neoplasms	Stem Cell Exhaustion	Little difference is made to relative risks if competing processes of proliferation and differentiation in the partially transformed stem and transit cell population are allowed for, nor is any difference made if one assumes that transit cells require an extra mutation to confer malignancy from the number required by stem cells.	28196079
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	Allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia who had central nervous system involvement: a study from the Adult ALL Working Group of the Japan Society for Hematopoietic Cell Transplantation.	28197965
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	The prognosis for adult acute lymphoblastic leukemia (ALL) patients with central nervous system (CNS) involvement (CNS+) who received allogeneic hematopoietic stem cell transplantation (allo-SCT) remains unclear.	28197965
Lymphoma	Stem Cell Exhaustion	Purpose The benefit of high-dose chemotherapy with autologous stem-cell transplantation (ASCT) as first-line treatment in patients with diffuse large B-cell lymphomas is still a matter of debate.	28199143
Hematological Disease	Stem Cell Exhaustion	In this study, we analyzed the safety of PICC placement in patients with hematologic diseases where PICCs had been placed to perform blood collection, blood transfusion, drug administration, and hematopoietic stem cell transplantation.	28202859
Cerebrovascular accident	Stem Cell Exhaustion	Spontaneous Recovery of Upper Extremity Motor Impairment After Ischemic Stroke: Implications for Stem Cell-Based Therapeutic Approaches.	28205065
Cerebrovascular accident	Stem Cell Exhaustion	Preclinical studies suggest that stem cell therapy (SCT) may improve sensorimotor recovery after stroke.	28205065
Lymphoma	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation in lymphoma patients is associated with a decrease in the double strand break repair capacity of peripheral blood lymphocytes.	28207808
Lymphoma, MLF1 gene	Stem Cell Exhaustion	Patients who undergo autologous hematopoietic stem cell transplantation (aHCT) for treatment of a relapsed or refractory lymphoma are at risk of developing therapy related- myelodysplasia/acute myeloid leukemia (t-MDS/AML).	28207808
Graft-vs-Host Disease, Engraftment syndrome	Stem Cell Exhaustion	Multivariate analysis showed that CBT, mycophenolate mofetil (MMF) for graft-versus-host disease prophylaxis, history of allogeneic hematopoietic stem cell transplantation (allo-HSCT), and engraftment syndrome (ES) were significantly associated with incidence of HHV-6 encephalitis/myelitis (P=.025, P=.017, P=.017, and P=.014, respectively).	28207973
Multiple Myeloma	Stem Cell Exhaustion	Impact of induction treatment before autologous stem cell transplantation on long-term outcome in patients with newly diagnosed multiple myeloma.	28208219
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Clinical trials for patients with multiple myeloma (MM) using novel agent (NA)-based regimens before autologous stem cell transplantation (SCT) have shown improvement in response rates and progression-free survival (PFS); however they have failed to identify a significant overall survival (OS) benefit.	28208219
Encephalitis, Neurogenic Inflammation	Stem Cell Exhaustion	Mesenchymal stem cells alleviate Japanese encephalitis virus-induced neuroinflammation and mortality.	28209182
Inflammation	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) have been demonstrated to have a therapeutic effect on many central nervous system (CNS) diseases by regulating inflammation and other mechanisms.	28209182
LMNA wt Allele	Stem Cell Exhaustion	Interestingly, SMCs derived from human induced pluripotent stem cells of HGPS donors (HGPS iPS-SMCs), but not from healthy donors, show an exacerbated inflammatory response to strain.	28211642
Malignant tumor of colon, Specialty Type - cancer	Stem Cell Exhaustion	Expression of the cancer stem cell markers ABCG2 and OCT-4 in right-sided colon cancer predicts recurrence and poor outcomes.	28212529
Specialty Type - cancer, Secondary Neoplasm, Refractory Cytopenia of Childhood	Stem Cell Exhaustion	Like cancer stem cells (CSCs), RCC cells cannot be fully eradicated and are often involved in relapse or metastasis.	28212529
Specialty Type - cancer, Adenocarcinoma Of Esophagus	Stem Cell Exhaustion	Expression profiles of cancer stem cell markers: CD133, CD44, Musashi-1 and EpCAM in the cardiac mucosa-Barrett's esophagus-early esophageal adenocarcinoma-advanced esophageal adenocarcinoma sequence.	28216140
Specialty Type - cancer	Stem Cell Exhaustion	A new hypothesis suggests that cancer is a disease of stem cells, however, their expression and pathways in BE - EAC sequence are not fully elucidated yet.	28216140
Specialty Type - cancer	Stem Cell Exhaustion	We used a panel of putative cancer stem cells markers to identify stem cells in consecutive steps of BE-related cancer progression.	28216140
Liver Cirrhosis, Autoimmune Diseases	Stem Cell Exhaustion	Effects of allogeneic mesenchymal stem cell transplantation in the treatment of liver cirrhosis caused by autoimmune diseases.	28217916
End Stage Liver Disease	Stem Cell Exhaustion	There has been great interest in recent years to take advantage of mesenchymal stem cells (MSCs) to treat end-stage liver disease.	28217916
Febrile Neutropenia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This prospective study included 87 adult hematological patients with febrile neutropenia after an intensive chemotherapy for acute myeloid leukemia (AML) or after an autologous stem cell transplantation (ASCT).	28218011
leukemia	Stem Cell Exhaustion	Leukemia microvesicles affect healthy hematopoietic stem cells.	28218044
leukemia	Stem Cell Exhaustion	In this study, we investigate the effect of leukemia microvesicles on healthy umbilical cord blood hematopoietic stem cells to find evidence of cell information transferring.	28218044
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Leukemia microvesicles were isolated from acute myeloid leukemia patients and were co-incubated with healthy hematopoietic stem cells.	28218044
leukemia	Stem Cell Exhaustion	Data showed a higher number of hematopoietic stem cells after being treated with leukemia microvesicles compared with control (treated with no microvesicles) and normal (treated with normal microvesicles) groups.	28218044
leukemia	Stem Cell Exhaustion	Our results suggest that leukemia microvesicles are able to induce some effects on healthy hematopoietic stem cells such as promoting cell survival and some microRNAs deregulation, while stemness is maintained.	28218044
Keratoconjunctivitis Sicca	Stem Cell Exhaustion	Chronic GvHD-related keratoconjunctivitis sicca (cGvHD-related KCS) can significantly alter the quality of life of patients after allogeneic hematopoietic stem cell transplantation.	28218751
Pneumonia	Stem Cell Exhaustion	CMV viral load in bronchoalveolar lavage for diagnosis of pneumonia in allogeneic hematopoietic stem cell transplantation.	28218754
Refractory Disease	Stem Cell Exhaustion	Sixty-seven patients received BV after autologous stem cell transplantation failure, whereas 28 patients were treated with BV without a prior autologous stem cell transplantation, due to advanced age/comorbidities or chemorefractory disease.	28219112
Pulmonary Complication, LYST gene, Chediak-Higashi Syndrome, Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	An 8-year-old girl with Chediak-Higashi syndrome (CHS) had pulmonary complications after hematopoietic stem cell transplantation (HSCT) for hemophagocytic lymphohistiocytosis (HLH) and eventually underwent single living-donor lobar lung transplantation (LDLLT).	28219570
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Patients with relapsed diffuse large B-cell lymphoma (DLBCL) not eligible for autologous stem cell transplantation (ASCT) or having relapse after ASCT have a low likelihood of cure.	28219694
Bone necrosis	Stem Cell Exhaustion	Treatment of stage II medication-related osteonecrosis of the jaw with necrosectomy and autologous bone marrow mesenchymal stem cells.	28220264
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	For refractory or relapsed acute myeloid leukemia patients, allogeneic hematopoietic stem cell transplantation is the only curative treatment option, but the disease must be in remission before this can be attempted.	28220349
Rhodococcus	Stem Cell Exhaustion	Rhodococcus Infection in Solid Organ and Hematopoietic Stem Cell Transplant Recipients1.	28221102
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Patients and Methods Patients age 18 to 59 years old with intermediate- or unfavorable-risk AML in first remission and no identified donor for allogeneic stem-cell transplantation (SCT) were eligible.	28221862
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation as frontline strategy for peripheral T-cell lymphoma: A single-centre experience.	28222648
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Objective To determine the efficacy and prognosis of autologous hematopoietic stem cell transplantation (ASCT) as frontline treatment for peripheral T cell lymphoma (PTCL).	28222648
Fecal Incontinence	Stem Cell Exhaustion	A new method for treating fecal incontinence by implanting stem cells derived from human adipose tissue: preliminary findings of a randomized double-blind clinical trial.	28222801
Fecal Incontinence	Stem Cell Exhaustion	Because human adipose-derived stromal/stem cells (hADSCs) are easier and safer to access, secrete high levels of growth factor, and have the potential to differentiate into muscle cells, we investigated the ability of hADSCs to improve anal sphincter incontinence.	28222801
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Genetic abnormalities in myelodysplasia and secondary acute myeloid leukemia: impact on outcome of stem cell transplantation.	28223278
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Genetic alterations, including mutations and copy-number alterations, are central to the pathogenesis of myelodysplastic syndromes and related diseases (myelodysplasia), but their roles in allogeneic stem cell transplantation have not fully been studied in a large cohort of patients.	28223278
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome (MDS) is a clonal stem cell disorder characterized by ineffective hematopoiesis with a high risk of transformation to acute myeloid leukemia (AML).	28224273
Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	miRNAs function as tumor suppressors and oncogenes in various cancers and regulate the differentiation potential of hematopoietic stem and progenitor cells (HSPCs).	28224273
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Multivariable Cox analysis showed that old age, higher International Prognostic Scoring System (IPSS) subtypes, transformation to AML, no history of hematopoietic stem cell transplantation and short average interphase TL (<433 TL) as independent prognostic factors for poorer survival (P=0.003, 0.001, 0.005, 0.005, and 0.013, respectively).	28224765
Specialty Type - cancer, Gastrointestinal mucositis	Stem Cell Exhaustion	Oral mucositis is a common and often debilitating complication among cancer patients receiving radiation therapy to the head and neck or chemotherapy agents, or undergoing hematopoietic stem cell transplantation.	28226414
Clostridium difficile colitis	Stem Cell Exhaustion	Evaluation of Risk Factors for Clostridium difficile Infection in Hematopoietic Stem Cell Transplant Recipients.	28226419
Clostridium difficile colitis, Hematologic Neoplasms, Central Diabetes Insipidus	Stem Cell Exhaustion	The primary objective was to determine the impact of hematologic malignancies and/or conditioning regimens on the risk of developing Clostridium difficile infection (CDI) in patients undergoing hematopoietic stem cell transplantation (HSCT).	28226419
Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy and autologous stem cell transplantation of patients with multiple myeloma in an outpatient setting.	28228122
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	High-dose (HD) chemotherapy with melphalan and autologous blood stem cell transplantation (ABSCT) for treatment of symptomatic multiple myeloma (MM) on an outpatient basis has been well established in the USA and Canada, whereas in Germany and Western Europe an inpatient setting is the current standard.	28228122
Gastrointestinal mucositis	Stem Cell Exhaustion	Supersaturated Calcium Phosphate Rinse in Prevention and Treatment of Mucositis in Patients Undergoing Hematopoietic Stem Cell Transplant.	28229803
Gastrointestinal mucositis	Stem Cell Exhaustion	Here, we assessed the efficacy of supersaturated calcium phosphate rinses in prevention and treatment of oral mucositis in patients undergoing hematopoietic stem cell transplant.	28229803
Gastrointestinal mucositis	Stem Cell Exhaustion	In this retrospective study, we evaluated the records of 80 patients who underwent hematopoietic stem cell transplant and received supersaturated calcium phosphate rinses for preVention of mucositis from April 2012 to January 2016.	28229803
Specialty Type - cancer	Stem Cell Exhaustion	Given the current hypothesis that cancer arises from cancer stem cells (CSCs), targeting the critical signaling pathways that support CSC self-renewal appears to be a useful approach for cancer therapy.	28230774
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Vildagliptin, but not glibenclamide, increases circulating endothelial progenitor cell number: a 12-month randomized controlled trial in patients with type 2 diabetes.	28231835
Diabetes	Stem Cell Exhaustion	Trial registration Clinical Trials number: NCT01822548; name: Effect of Vildagliptin vs. Glibenclamide on Circulating Endothelial Progenitor Cell Number Type 2 Diabetes.	28231835
Peripheral Blood Stem Cells	Stem Cell Exhaustion	We analyzed the impact of various graft sources and type of ABO mismatch on transplant outcomes for 1502 patients who underwent HCT at the University of Minnesota between 2000 and 2014: 312 receiving marrow (BM), 475 filgrastim-mobilized blood (peripheral blood stem cell [PBSC]), and 715 umbilical cord blood (UCB) grafts.	28232088
Hematologic Neoplasms	Stem Cell Exhaustion	To explore the lived experiences of patients with haematological malignancies who had been in protective isolation during their hospital stay for autologous haematopoietic stem cell transplantation.	28233359
Hematologic Neoplasms	Stem Cell Exhaustion	Nine patients with haematological malignancies who had been in protective isolation for autologous haematopoietic stem cell transplantation were enrolled.	28233359
Parkinson Disease	Stem Cell Exhaustion	Idiopathic Parkinson's disease patient-derived induced pluripotent stem cells function as midbrain dopaminergic neurons in rodent brains.	28233934
Adult Myelodysplastic Syndrome, Leukemia, Myelocytic, Acute, Organ Dysfunction Scores	Stem Cell Exhaustion	Patients with GATA2 (Emberger syndrome) deficiency needs early hematopoietic stem cell transplant (HSCT) before evolving in to myelodysplastic syndrome or acute myeloid leukemia and with time given compromised organ dysfunction leads to increase regimen-related toxicities.	28234738
Specialty Type - cancer	Stem Cell Exhaustion	Furthermore, new evidence on the existence of tumour-specific cancer stem cells that are long-lived and more quiescent and radioresistant than non-stem cancer cells can raise questions about their association with SMN risk.	28236557
Malignant Neoplasms	Stem Cell Exhaustion	Associations were stronger for rarer cancers and at tissue sites with lower rates of stem cell division.	28241208
MS gene	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation (AHSCT) may be effective in aggressive forms of multiple sclerosis (MS) that fail to respond to standard therapies.	28241268
Specialty Type - cancer, Chromosome Aberrations	Stem Cell Exhaustion	Centrosome aberrations and changes in stem cell numbers were examined to assess cancer susceptibility.	28245431
Carcinoma, Neuroendocrine, Tubular adenoma	Stem Cell Exhaustion	Coexisting tubular adenoma with a neuroendocrine carcinoma of colon allowing early surgical intervention and implicating a shared stem cell origin.	28246485
Carcinoma, Neuroendocrine	Stem Cell Exhaustion	In addition, the finding of a high-grade NEC within a large TA in this case suggests a link between the two lesions and could represent a shared stem cell origin.	28246485
Specialty Type - cancer, leukemia	Stem Cell Exhaustion	Leukemia inhibitory factor (LIF) has multiple functions in stem cell biology, the immune response, and cancer, and is potentially a key molecule that allows cancer stem cells to self-renew.	28247842
Chordoma, Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells, which are known to exist in chordomas, have extensive proliferative and self-renewal potential and are responsible for maintaining tumor heterogeneity along with chemotherapy and radiotherapy resistance.	28247842
Chordoma, Specialty Type - cancer	Stem Cell Exhaustion	Results indicate that LIF plays a role in maintaining cancer stem cells in chordomas.	28247842
Carcinoma, Neuroendocrine, Adenocarcinoma, Specialty Type - cancer	Stem Cell Exhaustion	The findings of this case suggest that adenocarcinoma and neuroendocrine carcinoma may be derived from a single cancer stem cell.	28248881
allergic inflammation	Stem Cell Exhaustion	Haemopoietic progenitor cells (HPC) migrate to sites of allergic inflammation where, upon stimulation with epithelial cytokines, they produce Th2 cytokines and differentiate into mature eosinophils and basophils.	28252235
Ischemic cardiomyopathy	Stem Cell Exhaustion	Effects of Transendocardial Stem Cell Injection on Ventricular Proarrhythmia in Patients with Ischemic Cardiomyopathy: Results from the POSEIDON and TAC-HFT Trials.	28252842
Ischemic cardiomyopathy, Ventricular arrhythmia, between breakfast and lunch	Stem Cell Exhaustion	Transendocardial stem cell injection in patients with ischemic cardiomyopathy (ICM) improves left ventricular function and structure but has ill-defined effects on ventricular arrhythmias.	28252842
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Rituximab with dose-adjusted EPOCH as first-line treatment in patients with highly aggressive diffuse large B-cell lymphoma and autologous stem cell transplantation in selected patients.	28252874
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	To assess the benefit of rituximab with dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (R-DA-EPOCH) regimen as a first-line treatment for patients with diffuse large B-cell lymphoma (DLBCL) presenting with unfavorable or aggressive features, and autologous stem cell transplantation (ASCT) as a part of the first-line treatment for selected DLBCL patients with additional aggressive features.	28252874
V-Series Nerve Agent VM, Malignant Neoplasms, Specialty Type - cancer, Neoplasm Metastasis, Aggressive course, Secondary Neoplasm	Stem Cell Exhaustion	Vasculogenic mimicry (VM; blood supply development often seen in highly aggressive cancers), aldehyde dehydrogenase 1 (ALDH1, cancer stem cell biomarker), KiSS-1 (suppressor of tumor metastasis), and metastasis associated in colon cancer-1 (MACC1) are all useful predictive factors for metastasis and prognosis in various cancers.	28253891
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Impact of ABO incompatibility on patients' outcome after haploidentical hematopoietic stem cell transplantation for acute myeloid leukemia - a report from the Acute Leukemia Working Party of the EBMT.	28255020
Acute GVH disease	Stem Cell Exhaustion	Focused analysis on stem cell source showed that patients with minor mismatching transplanted with bone marrow grafts experienced increased grade II-IV acute graft-versus-host disease rates (HR 2.03; 95% CI: 1.00-4.10; P=0.04).	28255020
Graft-vs-Host Disease	Stem Cell Exhaustion	Lactobacillus rhamnosus GG probiotic enteric regimen does not appreciably alter the gut microbiome or provide protection against GVHD after allogeneic hematopoietic stem cell transplantation.	28256022
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GVHD) is a major adverse effect associated with allogeneic stem cell transplant.	28256022
Graft-vs-Host Disease	Stem Cell Exhaustion	Previous studies in mice indicated that administration of the probiotic Lactobacillus rhamnosus GG can reduce the incidence of GVHD after hematopoietic stem cell transplant.	28256022
Graft-vs-Host Disease	Stem Cell Exhaustion	Additional studies are necessary to determine whether probiotics can alter the incidence of GVHD after allogeneic stem cell transplant.	28256022
Liver and Intrahepatic Biliary Tract Carcinoma, Genotype	Stem Cell Exhaustion	This straightforward concept however, is increasing imperiled by the recognition of primary liver carcinomas that do not subscribe to a dichotomous paradigm of differentiation, and instead demonstrate biphenotypic differentiation, stem/progenitor cell like features or other variant patterns of differentiation.	28256363
Genotype, Intrahepatic Cholangiocarcinoma, Primary Neoplasm, Chronic liver disease, Liver carcinoma	Stem Cell Exhaustion	Similar to hepatocellular carcinoma and in contrast with intrahepatic cholangiocarcinoma, primary liver tumors showing biphenotypic differentiation, stem/progenitor cell features or variant differentiation occur mainly, but not always, on a background of chronic liver disease.	28256363
Neoplasms	Stem Cell Exhaustion	Tumour neovessels are mostly lined by endothelial cells sprouting from nearby capillaries, but they could also be contributed by circulating endothelial progenitor cells (EPCs).	28258798
Hollings Cancer Center	Stem Cell Exhaustion	Data analysis of stem cells related genes in CD133+ cells of the HCC group compared to the control group showed that; CCND2, COL1A1, CTNNA1, DLL3, JAG1, KRT15, MYC, NOTCH2, T and TERT were up-regulated (fold change=80, 68.6, 6.67, 7.22, 3.8, 15.2, 14.5, 105.6, 26.6 and 99 respectively while only CD3D was down-regulated (fold change=0.055) in HCC patients.	28258914
Erectile dysfunction	Stem Cell Exhaustion	Li-ESWT activation of local penile progenitor cells might be one of the mechanisms that contribute to the beneficial effects of shockwave treatment for erectile dysfunction, which represents a non-invasive alternative to exogenous stem cell therapy.	28258952
Mandibular Fractures	Stem Cell Exhaustion	This study aimed to assess the advantages of autologous stem cell use for atrophic mandibular fracture treatment in comparison to standard technique.	28259617
Cortical Dysplasia, Epilepsy	Stem Cell Exhaustion	Induced pluripotent stem cells from patients with focal cortical dysplasia and refractory epilepsy.	28260047
nervous system disorder, Disease	Stem Cell Exhaustion	The generation of induced pluripotent stem cells (iPSCs) from the cells of patients with neurological diseases, and their subsequent tissue-specific differentiation, serves as an invaluable source for testing and studying the initial development and subsequent progression of diseases associated with the central nervous system.	28260047
Hodgkin Disease, Lymphoma, Multiple Myeloma, Rhabdomyosarcoma, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Among 16 patients who received hematopoietic stem cell transplant between January 2003 and January 2010, one patient underwent allogeneic bone marrow transplant for acute myeloid leukemia and 15 patients received autologous bone marrow transplant for the following indications: 5 had multiple myeloma, 9 had lymphoma (8 with Hodgkin disease and 1 with non- Hodgkin lymphoma), and 1 had rhabdomyosarcoma.	28260453
Hodgkin Disease	Stem Cell Exhaustion	Our results show that high-dose chemotherapy followed by autologous stem cell transplant can induce long-term disease control in this cohort of patients with refractory or advanced Hodgkin disease; progression-free survival for our cohort was 50%, with survival comparable to those reported in the literature.	28260453
Diabetes Mellitus, Insulin-Dependent	Stem Cell Exhaustion	Leptin Levels in Patients with Type 1 Diabetes Mellitus After Fetal Pancreatic Stem Cell Transplant.	28260466
Diabetes Mellitus, Insulin-Dependent, Pancreas Transplantation	Stem Cell Exhaustion	Our objective was to determine leptin levels in patients with type 1 diabetes mellitus after fetal pancreatic stem cell transplant.	28260466
Diabetes Mellitus, Insulin-Dependent	Stem Cell Exhaustion	Seven patients, aged 20 to 42 years, with type 1 diabetes mellitus received a fetal pancreatic stem cell transplant by intravenous infusion.	28260466
Diabetes Mellitus, Insulin-Dependent	Stem Cell Exhaustion	Leptin levels increase significantly within 3 months of fetal pancreatic stem cell transplant in patients with type 1 diabetes mellitus.	28260466
Herpes Simplex Infections	Stem Cell Exhaustion	Acyclovir-resistant herpes simplex virus 1 infection early after allogeneic hematopoietic stem cell transplantation with T-cell depletion.	28262533
Herpes Simplex Infections, Infection	Stem Cell Exhaustion	We previously reported that oral low-dose acyclovir (200 mg/day) for the prevention of herpes simplex virus (HSV) infections after allogenic hematopoietic stem cell transplantation (HSCT) is effective without the emergence of acyclovir-resistant HSV infections.	28262533
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Standard-dose 90yttrium-ibritumomab tiuxetan (.4 mci/kg) together with high-dose BEAM (BCNU, etoposide, cytarabine, and melphalan) (Z-BEAM) has been shown to be a well-tolerated autologous hematopoietic stem cell transplantation preparative regimen for non-Hodgkin lymphoma.	28267593
Myeloid Leukemia, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Although overexpression/activation of focal adhesion kinase (FAK) is widely known in solid tumors to control cell growth, survival, invasion, metastasis, gene expression, and stem cell self-renewal, its expression and function in myeloid leukemia are not well investigated.	28270436
Endometrial Carcinoma, Neoplasms	Stem Cell Exhaustion	There are few clinicopathologic studies with detailed immunohistochemical analysis regarding UCE/DCEs.We evaluated the diagnostic value of a selected tumor stem-cell marker and epithelial-mesenchymal transition (EMT) markers, in addition to previously studied markers in identifying UCE/DCEs from other types of high-grade endometrial carcinomas.Eleven cases of UCE/DCEs with complete clinical follow-up that were diagnosed between 2006 and 2015 were included in the study.	28272224
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Patients with high TACC3 expression showed CD133+ stem cell properties, glioma plasticity and shorter overall survival time under chemo-/radio-therapy.	28273854
Tuberculosis	Stem Cell Exhaustion	The demanding attention of tuberculosis in allogeneic hematopoietic stem cell transplantation recipients: High incidence compared with general population.	28278166
Tuberculosis	Stem Cell Exhaustion	The risk of developing tuberculosis (TB) in allogeneic hematopoietic stem cell transplantation (HSCT) recipients is expected to be relatively high in an intermediate TB burden country.	28278166
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Here, we report the first-in-human study exploiting a unique scalable NK-cell product generated ex vivo from CD34+ hematopoietic stem and progenitor cells (HSPC) from partially HLA-matched umbilical cord blood units.Experimental Design: Ten older AML patients in morphologic complete remission received an escalating HSPC-NK cell dose (between 3 and 30 x 106/kg body weight) after lymphodepleting chemotherapy without cytokine boosting.Results: HSPC-NK cell products contained a median of 75% highly activated NK cells, with <1 x 104 T cells/kg and <3 x 105 B cells/kg body weight.	28280089
Nasal Polyps	Stem Cell Exhaustion	During gene expression analysis and immunohistochemistry, we were able to detect different stem cell markers, like Oct-4, Sox2, Klf4, c-Myc, ABCG2, Nanog, CD133, and Nestin, which confirmed the existence of stem cell like cells within nasal polyps.	28280847
Nasal Polyps	Stem Cell Exhaustion	Our study demonstrated the expression of stem cell-related markers in nasal polyps.	28280847
Nasal Polyps	Stem Cell Exhaustion	Therefore, we investigated the stemness to determine the role of stem cells in nasal polyps, with additional analysis of the neuronal differentiation potential of nasal polyp cells.	28280847
Nasal Polyps	Stem Cell Exhaustion	We determined gene and protein expression profiles of stem cells in nasal polyp tissues, using whole genome microarray, quantitative real-time PCR (qPCR), immunohistochemistry, and flow cytometry.	28280847
Relapsing course	Stem Cell Exhaustion	A Phase I Trial of High-Dose Lenalidomide and Melphalan as Conditioning for Autologous Stem Cell Transplantation in Relapsed or Refractory Multiple Myeloma.	28285081
Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) conditioned with high-dose chemotherapy has long been established as the standard of care for eligible patients with newly diagnosed multiple myeloma.	28285081
Pulmonary Hypertension	Stem Cell Exhaustion	Very Small Embryonic-like Stem Cells Are Mobilized in Human Peripheral Blood during Hypoxemic COPD Exacerbations and Pulmonary Hypertension.	28285391
Squamous cell carcinoma of lung, Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Glioma-associated oncogene homolog 1 (Gli1) is involved in cancer stem cell (CSC) maintenance in various tumors; however, its expression and clinical significance in lung squamous cell carcinoma (LSCC) has not been reported.	28286162
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation (auto-HSCT) has improved survival in patients with multiple myeloma (MM) and is increasingly used in elderly patients.	28286198
Steroid-Refractory Pneumonitis	Stem Cell Exhaustion	Mesenchymal stromal cell infusion to treat steroid-refractory acute GvHD III/IV after hematopoietic stem cell transplantation.	28287644
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Acute GvHD (aGvHD) is a life-threatening complication of hematopoietic stem cell transplantation.	28287644
Periapical Diseases	Stem Cell Exhaustion	Expression of the stem cell factor in fibroblasts, endothelial cells, and macrophages in periapical tissues in human chronic periapical diseases.	28290616
Autosomal recessive inheritance, Pancytopenia	Stem Cell Exhaustion	In severe cases, usually inherited in an autosomal recessive pattern, the medullary cavity important in the production of normal blood cell progenitors is replaced by defective endochondral bone, leading to pancytopenia and consequential extramedullary hematopoiesis.	28290981
Lymphoma	Stem Cell Exhaustion	Patients with lymphoma that is chemotherapy refractory or relapsed after autologous stem-cell transplantation have a grim prognosis, and new treatments for these patients are clearly needed.	28291388
Chronic Obstructive Airway Disease, Pulmonary Emphysema	Stem Cell Exhaustion	We hypothesized that endothelial progenitor cell populations would be decreased in COPD and emphysema and that circulating endothelial cells would be increased.	28291826
Chronic Obstructive Airway Disease	Stem Cell Exhaustion	Among 257 participants, both endothelial progenitor cell populations, and particularly CD34+KDR+ endothelial progenitor cells, were reduced in COPD.	28291826
Panacinar Emphysema	Stem Cell Exhaustion	Both endothelial progenitor cell populations were associated inversely with extent of panlobular emphysema and positively with diffusing capacity.	28291826
Chronic Obstructive Airway Disease, Pulmonary Emphysema	Stem Cell Exhaustion	Endothelial progenitor cells in chronic obstructive pulmonary disease and emphysema.	28291826
Chronic Obstructive Airway Disease, Pulmonary Emphysema	Stem Cell Exhaustion	Endothelial injury is implicated in the pathogenesis of COPD and emphysema; however the role of endothelial progenitor cells (EPCs), a marker of endothelial cell repair, and circulating endothelial cells (CECs), a marker of endothelial cell injury, in COPD and its subphenotypes is unresolved.	28291826
Pulmonary Emphysema	Stem Cell Exhaustion	The CD34+KDR+CD133+ endothelial progenitor cells were associated inversely with emphysema extent.	28291826
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Long-term follow-up of patients receiving allogeneic stem cell transplant for chronic lymphocytic leukaemia: mixed T-cell chimerism is associated with high relapse risk and inferior survival.	28295181
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	There is limited information regarding the immunological predictors of post-allogeneic stem cell transplant (alloSCT) outcome in chronic lymphocytic leukaemia (CLL), such as mixed T-cell chimerism.	28295181
Multiple Myeloma	Stem Cell Exhaustion	Phase I study of cord blood-derived natural killer cells combined with autologous stem cell transplantation in multiple myeloma.	28295190
Gastric Carcinoid Tumor, Acute lymphocytic leukemia	Stem Cell Exhaustion	Development of a gastric carcinoid tumor following allogeneic hematopoietic stem cell transplantation for early T-cell precursor acute lymphoblastic leukemia.	28295914
Viral respiratory infection	Stem Cell Exhaustion	Respiratory virus infection after allogeneic hematopoietic stem cell transplant in a tropical center: Predictive value of the immunodeficiency scoring index.	28295964
Viral respiratory infection, Communicable Diseases	Stem Cell Exhaustion	Respiratory virus infection (RVI) is a prevalent infection in patients after allogeneic hematopoietic stem cell transplant (allo-HSCT) and can result in significant morbidity and mortality.	28295964
Hematologic Neoplasms, BK Virus, Hemorrhagic cystitis	Stem Cell Exhaustion	Nosocomial BK Polyomavirus Infection Causing Hemorrhagic Cystitis Among Patients With Hematological Malignancies After Hematopoietic Stem Cell Transplantation.	28295968
Hemorrhagic cystitis, Nephritis	Stem Cell Exhaustion	BK polyomavirus (BKPyV) is recognized as a pathogen that causes diseases such as hemorrhagic cystitis and nephritis after allogeneic hematopoietic stem cell transplantation (HSCT) or renal transplantation.	28295968
Phaeohyphomycosis	Stem Cell Exhaustion	Cutaneous phaeohyphomycosis in a hematopoietic stem cell transplant patient caused by Alternaria rosae: First case report.	28295973
Mycoses, Communicable Diseases	Stem Cell Exhaustion	Alternaria species have been reported as a rare cause of fungal infection in organ and stem cell transplant recipients, but to date, no reports have been published of infection in humans caused by Alternaria rosae.	28295973
Primary Myelofibrosis, Communicable Diseases	Stem Cell Exhaustion	Here, we report cutaneous A. rosae infection in a 66-year-old farmer with a history of primary myelofibrosis who had undergone allogeneic unrelated donor hematopoietic stem cell transplantation.	28295973
Prostate carcinoma, Secondary Neoplasm	Stem Cell Exhaustion	In vitro data suggest that adipose stromal/stem cells (ASCs) can increase production of cytokines and growth factors resulting in invasive growth and metastasis in prostate cancer.	28296186
methyldopa	Stem Cell Exhaustion	Vision Loss after Intravitreal Injection of Autologous "Stem Cells" for AMD.	28296617
Abnormal vision	Stem Cell Exhaustion	We evaluated three patients in whom severe bilateral visual loss developed after they received intravitreal injections of autologous adipose tissue-derived "stem cells" at one such clinic in the United States.	28296617
Hematologic Neoplasms, Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	There were 4 adult patients, of which 1 was actively receiving chemotherapy for chronic lymphocytic leukemia and 2 had undergone hematopoietic stem cell transplantation for hematologic malignancies.	28296681
Adult Glioblastoma	Stem Cell Exhaustion	Here, we show that m6A mRNA modification is critical for glioblastoma stem cell (GSC) self-renewal and tumorigenesis.	28297667
Adult Glioblastoma, Neoplastic Cell Transformation	Stem Cell Exhaustion	m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells.	28297667
Specialty Type - cancer	Stem Cell Exhaustion	However, the functions of N6-methyladenosine (m6A) mRNA modification in cancer biology and cancer stem cells remain largely unknown.	28297667
Intraepithelial Neoplasia, Intraductal Hyperplasia	Stem Cell Exhaustion	Multicolor immunofluorescence reveals that p63- and/or K5-positive progenitor cells contribute to normal breast epithelium and usual ductal hyperplasia but not to low-grade intraepithelial neoplasia of the breast.	28303349
Usual ductal hyperplasia	Stem Cell Exhaustion	Usual ductal hyperplasia showed striking similarity to normal luminal breast epithelium including p63+ and/or K5+ luminal progenitor cells and the full spectrum of luminal progeny cells.	28303349
Intraepithelial Neoplasia, Intraductal Hyperplasia	Stem Cell Exhaustion	From our data we conclude that p63+ and/or K5+ progenitor cells contribute to maintenance of normal epithelium and usual ductal hyperplasia, but not to low-grade intraepithelial neoplasia of the breast.	28303349
Aplastic Anemia	Stem Cell Exhaustion	Vascular and perivascular niches, but not the osteoblastic niche, are numerically restored following allogeneic hematopoietic stem cell transplantation in patients with aplastic anemia.	28303517
Squamous cell carcinoma	Stem Cell Exhaustion	Induced Pluripotent-stem-cell Related Genes Contribute to De-differentiation in Oral Squamous Cell Carcinoma.	28314267
Malignant Neoplasms	Stem Cell Exhaustion	Hypoxia affects cell differentiation and induces stem-cell-like characteristics in malignancies.	28314267
Specialty Type - cancer, Neoplasms, Malignant Neoplasms	Stem Cell Exhaustion	Cancer stem cells are suspected to contribute to malignancy in tumors.	28314267
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We used a targeted 28-gene NGS panel to detect mutations and different-from-normal 10-color MFC to measure MRD in AML patients before allogeneic hematopoietic stem cell transplantation (HCT).	28315400
FLT3 Internal Tandem Duplication	Stem Cell Exhaustion	FLT3-ITD mutations were detected in 33% of patients (2/6); 80% (4/5) of mutant patients died even after hematopoietic stem cell transplantation.	28318095
FLT3 Internal Tandem Duplication, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The retrospective study included 60 de novo adult AML patients diagnosed at our institution with normal karyotype, no FLT3-ITD or NPM1 mutations, and who did not receive allogeneic hematopoietic stem cell transplantations.	28318150
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We report an autopsied case showing PRES-like neuroradiological findings associated with premedication including tacrolimus for autologous peripheral blood stem cell transplantation in a 28-year-old woman with a 2-year history of acute myeloid sarcoma/acute myeloid leukemia.	28320172
Sample Size Calculation	Stem Cell Exhaustion	Enhanced numbers of EMPs, CFU-ECs and non-haematopoietic CD34+CD45- endothelial progenitor cells (EPCs) were observed in patients with SSc.	28320472
Allergic Reaction	Stem Cell Exhaustion	There were no infusional or allergic reactions and no difference in treatment-emergent adverse events between the groups (64 [99%] of 65 patients in the multipotent adult progenitor cell group vs 59 [97%] of 61 in the placebo group).	28320635
Cerebrovascular accident	Stem Cell Exhaustion	There was no difference between the multipotent adult progenitor cell group and placebo groups in global stroke recovery at day 90 (odds ratio 108 [95% CI 055-209], p=083).	28320635
Ischemic stroke	Stem Cell Exhaustion	Safety and efficacy of multipotent adult progenitor cells in acute ischaemic stroke (MASTERS): a randomised, double-blind, placebo-controlled, phase 2 trial.	28320635
Acute Cerebrovascular Accidents	Stem Cell Exhaustion	Multipotent adult progenitor cells are a bone marrow-derived, allogeneic, cell therapy product that modulates the immune system, and represents a promising therapy for acute stroke.	28320635
Cerebrovascular accident	Stem Cell Exhaustion	We aimed to identify the highest, well-tolerated, and safest single dose of multipotent adult progenitor cells, and if they were efficacious as a treatment for stroke recovery.	28320635
Ischemic stroke, Cerebrovascular accident	Stem Cell Exhaustion	We used a computer-generated randomisation sequence and interactive voice and web response system to assign patients aged 18-83 years with moderately severe acute ischaemic stroke and a National Institutes of Health Stroke Scale (NIHSS) score of 8-20 to treatment with intravenous multipotent adult progenitor cells (400 million or 1200 million cells) or placebo between 24 h and 48 h after symptom onset.	28320635
Ischemic stroke	Stem Cell Exhaustion	Administration of multipotent adult progenitor cells was safe and well tolerated in patients with acute ischaemic stroke.	28320635
Cerebrovascular accident	Stem Cell Exhaustion	Although no significant improvement was observed at 90 days in neurological outcomes with multipotent adult progenitor cells treatment, further clinical trials evaluating the efficacy of the intervention in an earlier time window after stroke (<36 h) are planned.	28320635
Aplastic Anemia	Stem Cell Exhaustion	Epstein-Barr virus (EBV)-associated lymphoproliferative disorders (LPDs) sometimes occur following Anti-thymocyte globulin (ATG) administration for allogenic stem cell transplantation but are rare in aplastic anemia (AA) patients.	28321074
Liver carcinoma, Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	AURKA promotes cancer metastasis by regulating epithelial-mesenchymal transition and cancer stem cell properties in hepatocellular carcinoma.	28322787
Specialty Type - cancer, Hollings Cancer Center	Stem Cell Exhaustion	While overexpression of AURKA induced epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) behaviors though PI3K/AKT pathway, silencing AURKA suppressed radiation-enhanced cell invasiveness of HCC.	28322787
Cerebrovascular accident	Stem Cell Exhaustion	However, it is essential to understand the traits of iSCs in the poststroke human brain for possible applications in stem cell-based therapies for stroke patients.	28323540
Cerebrovascular accident	Stem Cell Exhaustion	Identification of Multipotent Stem Cells in Human Brain Tissue Following Stroke.	28323540
Ischemia	Stem Cell Exhaustion	We previously demonstrated that brain pericytes near blood vessels also develop multipotency following experimental ischemia in mice and these ischemia-induced multipotent stem cells (iSCs) can contribute to neurogenesis.	28323540
Pancytopenia	Stem Cell Exhaustion	Given that TPO receptors are reportedly expressed in not only megakaryocyte progenitor cells but also hematopoietic progenitors, lusutrombopag may potentially improve pancytopenia caused by LC and can be used for the recovery of blood counts before other treatments.	28324272
Comorbidity, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Cytogenetics and comorbidity predict outcomes in older myelodysplastic syndrome patients after allogeneic stem cell transplantation using reduced intensity conditioning.	28324640
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only treatment with a curative potential for myelodysplastic syndrome (MDS) patients.	28324640
Hollings Cancer Center	Stem Cell Exhaustion	The aim of this study was to evaluate the diagnostic value of serum Wisteria Floribunda agglutinin-positive sialylated mucin 1 (WFA-sialylated MUC1), which is a novel biliary marker, as a marker of HCC with hepatic progenitor cell (HPC)/biliary features and of prognosis.	28325920
Malignant neoplasm of stomach, Specialty Type - cancer	Stem Cell Exhaustion	Polymorphisms of cancer stem cell marker gene CD133 are associated with susceptibility and prognosis of gastric cancer.	28326835
Malignant neoplasm of stomach, Specialty Type - cancer	Stem Cell Exhaustion	This study was aimed to investigate the associations between single nucleotide polymorphisms of cancer stem cell marker genes, CD44 and CD133, and susceptibility and prognosis of gastric cancer.	28326835
Hodgkin Disease	Stem Cell Exhaustion	Risk factors and a prognostic score for survival after autologous stem-cell transplantation for relapsed or refractory Hodgkin lymphoma.	28327958
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Stem Cell Exhaustion	We present a case study of a 3-year-old girl with precursor T-cell acute lymphoblastic leukemia who received intravenous busulfan before hematopoietic stem cell transplantation.	28328762
Bone marrow hypocellularity, Anemia, Hemolytic, Thromboembolism, Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH) is a nonmalignant acquired hematopoietic stem cell disease, which can be revealed by hemolytic anemia, thromboembolism, or bonemarrow failure.	28328837
Clostridium difficile colitis	Stem Cell Exhaustion	Evaluating Risk Factors for Clostridium difficile Infection In Stem Cell Transplant Recipients: A National Study.	28330512
Clostridium difficile colitis, Dysentery, Central Diabetes Insipidus	Stem Cell Exhaustion	OBJECTIVE Large-scale studies evaluating risk factors for Clostridium difficile infection (CDI), a leading cause of infectious diarrhea among patients undergoing stem cell transplantation (SCT), are lacking.	28330512
Lymphoma, Follicular, Mucosa-associated lymphoid tissue (MALT) lymphoma of orbit	Stem Cell Exhaustion	Orbital MALT Lymphoma after Autologous Stem Cell Transplantation for Follicular Lymphoma as Relapse of Diffuse Large B-Cell Lymphoma.	28331132
Lymphoma, Follicular, B-Cell Lymphomas, Mucosa-associated lymphoid tissue (MALT) lymphoma of orbit	Stem Cell Exhaustion	We report a patient who developed orbital MALT lymphoma after autologous peripheral blood stem cell transplantation for follicular lymphoma as relapse of diffuse large B-cell lymphoma.	28331132
Lymphoma, Mucosa-Associated Lymphoid Tissue Lymphoma	Stem Cell Exhaustion	Relapse as MALT lymphoma after hematopoietic stem cell transplantation for relapsed and refractory lymphoma may not be a poor prognostic sign.	28331132
Chronic granulomatous disease	Stem Cell Exhaustion	Disseminated Lichtheimia ramosa Infection After Hematopoietic Stem Cell Transplantation in a Child With Chronic Granulomatous Disease.	28333712
Chronic granulomatous disease, Thrombosis	Stem Cell Exhaustion	We report a 7-year-old boy with X-linked CGD and absent oxidative burst who developed fatal Lichtheimia ramosa infection with fungal thrombosis of the kidneys, spleen and other organs after hematopoietic stem cell transplantation.	28333712
Malignant Peripheral Nerve Sheath Tumor, Myeloproliferative disease	Stem Cell Exhaustion	Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell (HSC) disorders that can be classified on the basis of genetic, clinical, phenotypic features.	28335073
Limbal stem cell deficiency	Stem Cell Exhaustion	Paediatric idiopathic limbal stem cell deficiency.	28336223
Inflammation, Trauma, Hypersensitivity	Stem Cell Exhaustion	Acquired limbal stem cell deficiency (LSCD) describes a condition in which the corneal limbal stem cells are altered or destroyed, typically due to ocular trauma, chronic allergy or inflammation.	28336223
Failure	Stem Cell Exhaustion	Idiopathic LSCD is a term used to describe limbal stem cell failure in the absence of any identifiable causative factor.	28336223
Unknown (origin) (qualifier value)	Stem Cell Exhaustion	While several cases of adult-onset LSCD have been identified previously, this case report describes a rare presentation of bilateral asymmetric idiopathic paediatric limbal stem cell deficiency in a sixteen-year-old male with an otherwise unremarkable ocular history.	28336223
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Allogeneic Hematopoietic Stem Cell Transplantation Is Underutilized in Older Patients with Myelodysplastic Syndromes.	28336325
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HCT) is the only curative treatment for myelodysplastic syndrome (MDS).	28336325
Thrombosis of blood vessel	Stem Cell Exhaustion	Deficiency of circulating progenitor cells associated with vascular thrombosis of hemodialysis patients.	28339557
HD Term Type	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs), which function in vascular repair, are deficient in HD patients.	28339557
Adult T-Cell Lymphoma/Leukemia	Stem Cell Exhaustion	Although allogeneic stem cell transplantation after chemotherapy is a recommended treatment option for patients with aggressive adult T-cell leukemia-lymphoma, there is no consensus about indications for allogeneic stem cell transplantation because there is no established risk stratification system for transplant eligible patients.	28341734
Adult T-Cell Lymphoma/Leukemia	Stem Cell Exhaustion	We developed a promising new risk stratification system to identify patients aged 70 years or younger with aggressive adult T-cell leukemia-lymphoma who may benefit from upfront allogeneic stem cell transplantation.	28341734
Leukemic Hematopoietic Stem Cell	Stem Cell Exhaustion	Gene set enrichment analysis showed higher HOPX expression was associated with both hematopoietic and leukemia stem cell signatures.	28341738
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	While HOPX and HOX family genes showed concordant expression patterns in normal hematopoietic stem/progenitor cells, their expression patterns and associated clinical and biological features were distinctive in AML settings, demonstrating HOPX to be a unique homeobox gene.	28341738
Shwachman syndrome	Stem Cell Exhaustion	First experience of hematopoietic stem cell transplantation treatment of Shwachman-Diamond syndrome using unaffected HLA-matched sibling donor produced through preimplantation HLA typing.	28346418
Allogeneic Hematopoietic Stem Cell Transplantation, Bone marrow hypocellularity, Shwachman syndrome	Stem Cell Exhaustion	The only proven cure for Shwachman-Diamond syndrome (SDS) bone marrow failure is allogeneic hematopoietic stem cell transplantation (HSCT).	28346418
Retinal Diseases	Stem Cell Exhaustion	Retina tissue engineering by conjunctiva mesenchymal stem cells encapsulated in fibrin gel: Hypotheses on novel approach to retinal diseases treatment.	28351499
Disease, physiopathological, methyldopa	Stem Cell Exhaustion	Our hypothesis suggests that using human conjunctiva stem cells (as the source for increasing the number of human stem cells progenitor cells in retina dysfunction diseases) with fibrin gel and also assessing its relating in vitro (cellular and molecular processes) and in vivo (vision tests and pathology) could be a promising strategy for treatment of AMD and RP disorders.	28351499
Reticulon-4 Receptor-Like 1, Human	Stem Cell Exhaustion	In this idea, we describe a novel approach for retina tissue engineering with differentiation of conjunctiva mesenchymal stem cells (CJMSCs) into photoreceptor-like cells in fibrin gel with induction medium contain taurine.	28351499
Retinal Degeneration	Stem Cell Exhaustion	In retinal transplantation studies, stem and progenitor cells inject into the sub retinal space or vitreous and then these cells can be migrate to the site of retinal degeneration and locate in the host retina and restitute vision.	28351499
Acute leukemia	Stem Cell Exhaustion	Endoglin (CD105), a receptor of the transforming growth factor-b superfamily, has been reported to identify functional long-term repopulating hematopoietic stem cells, and has been detected in certain subtypes of acute leukemias.	28351936
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	In multiple myeloma (MM), relapse is a problem after autologous hematopoietic stem cell transplantation (ASCT).	28355602
Neutropenia, B-Cell Lymphomas	Stem Cell Exhaustion	Incidence of late onset neutropenia associated with rituximab use in B cell lymphoma patients undergoing autologous stem cell transplantation.	28358279
Neutropenia, B-Cell Lymphomas	Stem Cell Exhaustion	Reversible late onset neutropenia associated with rituximab has been reported with incidence rates varying from 15 to 70% in B cell lymphoma patients receiving autologous stem cell transplantation.	28358279
B-Cell Lymphomas	Stem Cell Exhaustion	We conducted a retrospective descriptive study at one tertiary care center in adult B cell lymphoma patients treated with rituximab and autologous stem cell transplantation between 1 January 2004 and 30 June 2014.	28358279
Neutropenia	Stem Cell Exhaustion	Late onset neutropenia was defined as an absolute neutrophil count <1.0 x 109 cells/L after neutrophil engraftment and less than six months post autologous stem cell transplantation.	28358279
Neutropenia	Stem Cell Exhaustion	In conclusion, rituximab with mobilization or high dose chemotherapy may increase the risk of late onset neutropenia post autologous stem cell transplantation.	28358279
Non-Small Cell Lung Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Nestin is a class VI intermediate filament protein expressed in neural stem cells and several cancer cells including NSCLC.	28358810
Gastrointestinal mucositis	Stem Cell Exhaustion	The aim of this study was to analyze the influence of dietary supplementation with whey protein concentrate (WPC) in the incidence of oral mucositis (OM) in patients undergoing hematopoietic stem cell transplantation (HSCT).	28359354
Agranulocytosis lab result	Stem Cell Exhaustion	The observation of colony forming units of progenitor cells in dishes that contained the patient's serum, provided inconclusive explanation of the possible mechanism of DFP-induced agranulocytosis.	28361596
Somatic mosaicism, Nevoid, Basal Cell Nevus Syndrome	Stem Cell Exhaustion	Somatic mosaicism containing double mutations in PTCH1 revealed by generation of induced pluripotent stem cells from nevoid basal cell carcinoma syndrome.	28363938
Multiple Myeloma	Stem Cell Exhaustion	Multiple myeloma patients in long-term complete response after autologous stem cell transplantation express a particular immune signature with potential prognostic implication.	28368375
Multiple Myeloma	Stem Cell Exhaustion	The proportion of multiple myeloma patients in long-term complete response (LTCR-MM) for more than 6 years after autologous stem cell transplantation (ASCT) is small.	28368375
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Prognostic impact of the European LeukemiaNet standardized reporting system in older AML patients receiving stem cell transplantation after non-myeloablative conditioning.	28368377
Neoplasm Metastasis	Stem Cell Exhaustion	Significant risk factors for the development of t-AML/MDS after autologous and allogeneic HCT were high-stage risk at HCT (P=0.04) or secondary malignancies (P<0.001) and receiving cord blood stem cell (P=0.03) or involved field radiotherapy (P=0.002), respectively.	28368379
Congenital infectious disease, Milk (body substance), Vitreous humor	Stem Cell Exhaustion	Next-generation sequencing was performed on target enriched sequence libraries prepared directly from a variety of clinical specimens (blood, urine, breast milk, respiratory samples, biopsies, and vitreous humor) obtained longitudinally or from different anatomical compartments from 20 HCMV-infected patients (renal transplant recipients, stem cell transplant recipients, and congenitally infected children).	28368496
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Feasibility of allogeneic stem-cell transplantation after azacitidine bridge in higher-risk myelodysplastic syndromes and low blast count acute myeloid leukemia: results of the BMT-AZA prospective study.	28368509
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Allogeneic stem-cell transplantation (HSCT) is the only curative treatment in myelodysplastic syndromes (MDS).	28368509
Infection of bloodstream	Stem Cell Exhaustion	Prediction of Bloodstream Infection Due to Vancomycin-Resistant Enterococcus in Patients Undergoing Leukemia Induction or Hematopoietic Stem-Cell Transplantation.	28369204
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Allogeneic stem cell transplantation in patients with atypical chronic myeloid leukaemia: a retrospective study from the Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation.	28369779
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative, Aggressive course, Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Atypical chronic myeloid leukaemia (aCML) is an aggressive malignancy for which allogeneic haematopoietic stem cell transplantation (allo-HSCT) represents the only curative option.	28369779
Primary central nervous system lymphoma	Stem Cell Exhaustion	High-dose chemotherapy with thiotepa, busulfan, and cyclophosphamide and autologous stem cell transplantation for patients with primary central nervous system lymphoma in first complete remission.	28369839
Primary central nervous system lymphoma	Stem Cell Exhaustion	High-dose chemotherapy and autologous stem cell transplantation (HDC-ASCT) is a therapeutic option for patients with primary central nervous system lymphoma (PCNSL).	28369839
Primary Myelofibrosis	Stem Cell Exhaustion	Is allogeneic stem cell transplantation for myelofibrosis still indicated at the time of molecular markers and JAK inhibitors era?	28370306
Primary Myelofibrosis	Stem Cell Exhaustion	The role of allogenic stem cell transplantation (ASCT) is still debated in myelofibrosis (MF).	28370306
Acute leukemia, Leukemia, Myelocytic, Acute, Leukocytosis	Stem Cell Exhaustion	Long term impact of hyperleukocytosis in newly diagnosed acute myeloid leukemia patients undergoing allogeneic stem cell transplantation: An analysis from the acute leukemia working party of the EBMT.	28370339
Leukemia, Myelocytic, Acute, Leukocytosis	Stem Cell Exhaustion	Yet, it is unknown whether hyperleukocytosis still retains prognostic value for AML patients undergoing hematopoietic stem cell transplantation (HSCT).	28370339
Multiple Myeloma	Stem Cell Exhaustion	Cyclophosphamide-based stem cell mobilization in relapsed multiple myeloma patients: A subgroup analysis from the phase III trial ReLApsE.	28370401
Toxic effect, Multiple Myeloma	Stem Cell Exhaustion	Analysis of the efficiency and toxicity of cyclophosphamide-based stem cell mobilization in patients with relapsed multiple myeloma (RMM).	28370401
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Since a study published in 2002 showed a survival advantage of melphalan-only conditioning for stem cell transplantation (HSCT) over melphalan-total body irradiation (mel-TBI) in patients with multiple myeloma (MM), most centers abandoned mel-TBI.	28370630
Specialty Type - cancer	Stem Cell Exhaustion	Finally, we observed that increased stromal TILs and PDL1 expression were significantly associated with cancer stem cell (CSC) markers, basal cell markers and vimentin expression.	28373294
Vaginal Hemorrhage	Stem Cell Exhaustion	Continuation of hormonal intrauterine devices (IUDs) - widely used and highly effective contraceptives that also decrease menstrual flow - is controversial during hematopoietic stem cell transplants (SCTs) due to infectious and vaginal bleeding concerns.	28373471
Malignant tumor of colon, Specialty Type - cancer	Stem Cell Exhaustion	Cancer Stem Cell Gene Variants in CD44 Predict Outcome in Stage II and Stage III Colon Cancer Patients.	28373475
Mastocytosis, Specialty Type - cancer, Malignant Neoplasms, Malignant tumor of colon	Stem Cell Exhaustion	Growing evidence suggests that human cancers are stem cell diseases and recent data support the existence of cancer stem cells (CSCs) in a variety of malignancies, including colon cancer.	28373475
Malignant tumor of colon	Stem Cell Exhaustion	The purpose of the present study was to assess the impact of single-nucleotide polymorphisms (SNPs) in stem cell-related genes on clinical outcome in a large cohort of colon cancer patients with clinical stage II and III.	28373475
Malignant tumor of colon	Stem Cell Exhaustion	Germline variants rs13347 and rs187115 in the stem cell gene CD44 are prognostically relevant in stage II and III colon cancer patients.	28373475
Degenerative polyarthritis	Stem Cell Exhaustion	Enumeration and Localization of Mesenchymal Progenitor Cells and Macrophages in Synovium from Normal Individuals and Patients with Pre-Osteoarthritis or Clinically Diagnosed Osteoarthritis.	28379175
Cartilage damage	Stem Cell Exhaustion	Few studies have examined the cellular composition (inflammatory cells and/or progenitor cells) in the synovium of patients with pre-OA (asymptomatic with cartilage damage).	28379175
Degenerative polyarthritis	Stem Cell Exhaustion	Therefore, in the current study, mesenchymal progenitor cells (MPCs) and macrophages were enumerated within normal, pre-OA and OA synovium.	28379175
Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy plus autologous stem-cell transplantation has been the standard treatment for newly diagnosed multiple myeloma in adults up to 65 years of age.	28379796
Multiple Myeloma	Stem Cell Exhaustion	We randomly assigned 700 patients with multiple myeloma to receive induction therapy with three cycles of RVD and then consolidation therapy with either five additional cycles of RVD (350 patients) or high-dose melphalan plus stem-cell transplantation followed by two additional cycles of RVD (350 patients).	28379796
Malignant Neoplasms	Stem Cell Exhaustion	Expression of mesenchymal stem cell markers contributed to the inherent heterogeneity in the malignant tumors.	28380418
Carcinogenesis	Stem Cell Exhaustion	Overall, we found that progastrin binds to GPR56 expressing colonic stem cells, which in turn promotes their expansion, and that this GPR56-dependent pathway is an important driver and potential new target in colorectal carcinogenesis.	28380450
Specialty Type - cancer	Stem Cell Exhaustion	Dicer1 and cancer stem cells play important roles in cell motility and survival.	28381177
Cardiomyopathies	Stem Cell Exhaustion	Phase I Clinical Trial of Autologous Stem Cell-Sheet Transplantation Therapy for Treating Cardiomyopathy.	28381469
Specialty Type - cancer, Intestinal Neoplasms, Malignant neoplasm of prostate	Stem Cell Exhaustion	Recently, DCLK1 has been reported to act as an intestinal tumor stem cell marker and has been shown to be expressed in cancer cells and in the stroma of breast, colon, pancreatic, and prostate cancers.	28382517
Bone Diseases	Stem Cell Exhaustion	This phase II study explored the effects of bortezomib consolidation versus observation on myeloma-related bone disease in patients who had a partial response or better after frontline high-dose therapy and autologous stem cell transplantation.	28382618
LACRIMAL DUCT DEFECT	Stem Cell Exhaustion	Cardiac involvement by LCDD was seen in one-third of our patients and was associated with shorter overall survival; such patients also had a significantly higher risk of treatment-related mortality (TRM) after stem cell transplant (SCT) compared to LCDD patients without cardiac involvement.	28383130
Aggressive behavior, Specialty Type - cancer	Stem Cell Exhaustion	Meanwhile, cancer stem cells (CSCs) are also characterized by a strong tumorigenic potential, which might be partly responsible for the aggressive behavior of TNBC.	28383433
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	SRT1720 promotes survival of aged human mesenchymal stem cells via FAIM: a pharmacological strategy to improve stem cell-based therapy for rat myocardial infarction.	28383554
Humor	Stem Cell Exhaustion	We have shown previously that transplantation of induced pluripotent stem cell (iPSC) derived TM cells restores aqueous humor dynamics in young transgenic mice expressing a pathogenic form of human myocilin (Tg-MYOCY437H).	28384726
Glaucoma, CTCAE	Stem Cell Exhaustion	This type of stem cell-based therapy is a promising possibility for restoration of IOP control in some glaucoma patients.	28384726
Myeloid Leukemia, Chronic, BCR gene	Stem Cell Exhaustion	The objective of this study was to compare overall survival (OS) between patients with CML and those with Ph+ ALL who received treatment with ponatinib versus allogeneic stem cell transplantation (allo-SCT).	28387926
Primary Myelofibrosis	Stem Cell Exhaustion	Impact of Molecular Genetics on Outcome in Myelofibrosis Patients after Allogeneic Stem Cell Transplantation.	28389256
Primary Myelofibrosis, Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase	Stem Cell Exhaustion	To determine the impact of molecular genetics on outcome after allogeneic stem cell transplantation, we screened 169 patients with primary myelofibrosis (n = 110), post-essential thrombocythemia/polycythemia vera myelofibrosis (n = 46), and myelofibrosis in transformation (n = 13) for mutations in 16 frequently mutated genes.	28389256
Primary Myelofibrosis	Stem Cell Exhaustion	Molecular genetics, especially CALR, IDH2, and ASXL1 mutations, may thus be useful to predict outcome independently from known clinical risk factors after allogeneic stem cell transplantation for myelofibrosis.	28389256
Central Nervous System, graft loss, Vertigo , Diplopia	Stem Cell Exhaustion	Seven months later, he developed central nervous system PTLD, presenting with vertigo and diplopia; immunosuppression was discontinued, resulting in graft loss, and he was given high-dose methotrexate and underwent consolidative autologous stem cell transplantation.	28390107
Lymphoma	Stem Cell Exhaustion	Allogeneic Stem Cell Transplantation for Relapsed/Refractory B Cell Lymphomas: Results of a Multicenter Phase II Prospective Trial including Rituximab in the Reduced-Intensity Conditioning Regimen.	28390983
S100A4 protein, human	Stem Cell Exhaustion	The prevention of oncogene-induced DNA damage precludes induction of the oncosuppressive p53-dependent DNA-damage response, thereby increasing stem cells' intrinsic susceptibility to malignant transformation.	28394329
Amyloidosis	Stem Cell Exhaustion	Revisiting conditioning dose in newly diagnosed light chain amyloidosis undergoing frontline autologous stem cell transplant: impact on response and survival.	28394369
Amyloidosis	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) is an important treatment modality in light chain (AL) amyloidosis.	28394369
Amyloidosis	Stem Cell Exhaustion	Stem cell transplantation in patients with systemic AL amyloidosis referred for transplant after suboptimal responses to bortezomib-based initial therapy.	28394371
Blood Vessel	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) play a role in vascular repair, while circulating endothelial cells (CECs) are biomarkers of vascular damage and regeneration.	28394933
Neoplasms	Stem Cell Exhaustion	High-dose chemotherapy with autologous stem cell rescue is commonly used for the treatment of relapsed germ cell tumors.	28395668
Rhabdomyolysis, Myalgia	Stem Cell Exhaustion	His course was complicated by muscle pain and rhabdomyolysis after cycle 4 on day +12 after infusion of autologous stem cells.	28395668
Rett Syndrome	Stem Cell Exhaustion	Generation of a clonal induced pluripotent stem cell (iPSC) line expressing the mutant MECP2 allele from a Rett Syndrome patient fibroblast line.	28395743
Hypertrophic Cardiomyopathy	Stem Cell Exhaustion	Peripheral blood derived induced pluripotent stem cells (iPSCs) from a female with familial hypertrophic cardiomyopathy.	28395744
Hypertrophic Cardiomyopathy, Health maintenance	Stem Cell Exhaustion	Induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells (PBMCs) obtained from a 62-year-old female with familial hypertrophic cardiomyopathy (HCM).	28395744
alpha-Thalassemia	Stem Cell Exhaustion	In this study the MUi009-A human induced pluripotent stem cell line was successfully generated from peripheral blood CD34+ haematopoietic progenitors of a 32year old male who had coinherited a homozygous bdeg-thalassemia mutation at codon 41/42 (-TCTT) and a heterozygous a-thalassemia 4.2 deletion.	28395745
alpha-Thalassemia	Stem Cell Exhaustion	Establishment of MUi009 - A human induced pluripotent stem cells from a 32year old male with homozygous bdeg-thalassemia coinherited with heterozygous a-thalassemia 2.	28395745
Hypertrophic Cardiomyopathy	Stem Cell Exhaustion	Generation of induced pluripotent stem cells (iPSCs) from a hypertrophic cardiomyopathy patient with the pathogenic variant p.Val698Ala in beta-myosin heavy chain (MYH7) gene.	28395747
Hypertrophic Cardiomyopathy, Health maintenance	Stem Cell Exhaustion	Induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells (PBMCs) isolated from the whole blood of a 43-year-old male with hypertrophic cardiomyopathy (HCM) who carries the pathogenic variant p.Val698Ala in beta-myosin heavy chain (MYH7).	28395747
Parkinson Disease	Stem Cell Exhaustion	Reprogramming of a human induced pluripotent stem cell (iPSC) line from a Parkinson's disease patient with a R1628P variant in the LRRK2 gene.	28395802
Parkinson Disease	Stem Cell Exhaustion	Derivation of human induced pluripotent stem cell (iPSC) line with LRRK2 gene R1398H variant in Parkinson's disease.	28395803
Parkinson Disease	Stem Cell Exhaustion	Development of a human induced pluripotent stem cell (iPSC) line from a Parkinson's disease patient carrying the N551K variant in LRRK2 gene.	28395804
Parkinson Disease	Stem Cell Exhaustion	Generation of a human induced pluripotent stem cell (iPSC) line carrying the Parkinson's disease linked LRRK2 variant S1647T.	28395805
Multiple Endocrine Neoplasia	Stem Cell Exhaustion	Generation of non-integrated induced pluripotent stem cells from a 59-year-old female with multiple endocrine neoplasia type 1 syndrome.	28395808
Multiple Endocrine Neoplasia	Stem Cell Exhaustion	Generation of non-integrated induced pluripotent stem cells from a 23-year-old male with multiple endocrine neoplasia type 1 syndrome.	28395810
Hematologic Neoplasms	Stem Cell Exhaustion	Ex vivo T-cell-depleted allogeneic stem cell transplantation for hematologic malignancies: The search for an optimum transplant T-cell dose and T-cell add-back strategy.	28395942
Graft-vs-Host Disease	Stem Cell Exhaustion	T-cell depletion (TCD) of allogeneic stem cell transplants (SCT) can reduce graft-versus-host disease but may negatively affect transplant outcome by delaying immune recovery.	28395942
Injury of kidney	Stem Cell Exhaustion	A Time-to-Event Model for Acute Kidney Injury after Reduced-Intensity Conditioning Stem Cell Transplantation Using a Tacrolimus- and Sirolimus-based Graft-versus-Host Disease Prophylaxis.	28396159
Kidney Failure, Acute	Stem Cell Exhaustion	There is a paucity of data evaluating acute kidney injury (AKI) incidence and its relationship with the tacrolimus-sirolimus (Tac-Sir) concentrations in the setting of reduced-intensity conditioning (RIC) after allogeneic stem cell transplantation (allo-HSCT).	28396159
leukemia	Stem Cell Exhaustion	Isolated Extramedullary Relapse of Acute Leukemia after Allogeneic Stem Cell Transplantation: Different Kinetics and Better Prognosis than Systemic Relapse.	28396161
Acute leukemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic stem cell transplantation (SCT) is curative treatment in patients with acute leukemia and myelodysplastic syndrome.	28396161
Malignant neoplasm of ovary, Specialty Type - cancer	Stem Cell Exhaustion	Proliferation and maturation of intratumoral blood vessels in women with malignant ovarian tumors assessed with cancer stem cells marker nestin and platelet derived growth factor PDGF-B.	28397199
Gastrointestinal Stromal Tumors	Stem Cell Exhaustion	This study ascertained the regulation of the stem cell marker CD133 and its potential applicability for prognostication of gastrointestinal stromal tumors (GISTs).	28398518
Graft-vs-Host Disease	Stem Cell Exhaustion	Sequential monitoring of lymphocyte subsets and of T-and-B cell neogenesis indexes to identify time-varying immunologic profiles in relation to graft-versus-host disease and relapse after allogeneic stem cell transplantation.	28399164
Graft-vs-Host Disease, Hematologic Neoplasms	Stem Cell Exhaustion	T and B lymphocyte subsets have been not univocally associated to Graft-versus-host disease (GVHD) and relapse of hematological malignancies after stem cell transplantation (SCT).	28399164
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Within this retrospective single-center study, we analyzed the survival of 320 multiple myeloma (MM) patients receiving melphalan high-dose chemotherapy (HDCT) and either single (n = 286) or tandem (n = 34) autologous stem cell transplantation (ASCT) from 1996 to 2012.	28399522
Metastatic Malignant Neoplasm to the Leptomeninges	Stem Cell Exhaustion	Overexpression of syndecan-1, MUC-1, and putative stem cell markers in breast cancer leptomeningeal metastasis: a cerebrospinal fluid flow cytometry study.	28399903
Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	We focused on one of the most aggressive circulating tumor cells (CTCs) which, from the primitive tumor, spreads to the central nervous system (CNS), evaluating the expression of prognostic and putative cancer stem cell markers in breast cancer (BC) leptomeningeal metastasis (LM).	28399903
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Syndecan-1 (CD138), MUC-1 (CD227) CD45, CD34, and the putative cancer stem cell markers CD15, CD24, CD44, and CD133 surface expression were evaluated on CSF floating tumor cells.	28399903
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	This in vivo study documents that CSF floating BC cells overexpress prognostic and putative cancer stem cell biomarkers related to tumor invasiveness, potentially representing a molecular target for circulating tumor cell detection and LM treatment monitoring, as well as a primary target for innovative treatment strategies.	28399903
Hemorrhagic cystitis	Stem Cell Exhaustion	Dynamics of BKPyV reactivation and risk of hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation.	28401591
craniofacial, Retinal defect	Stem Cell Exhaustion	The objective of this case study was to demonstrate the feasibility of a novel cell therapy treatment for localized jaw bone defects with tissue repair cells composed of a mixture of bone marrow-derived cells, including CD90+ mesenchymal stem cells and CD105+ monocytes/macrophages, and xenograft blocks, in what would be a safe and efficacious approach to the regeneration of localized craniofacial bone defects.	28402346
Multiple Myeloma	Stem Cell Exhaustion	A prospective, open-label, multicenter, observational study to evaluate the efficacy and safety of bortezomib-melphalan-prednisone as initial treatment for autologous stem cell transplantation-ineligible patients with multiple myeloma.	28402945
Thalassemia	Stem Cell Exhaustion	Of the thalassemia major patients, 5.8% had match-related hemopoietic stem cell transplantation with a success rate of 77%.	28404539
Extrapulmonary Small Cell Carcinoma	Stem Cell Exhaustion	Taken together, these results demonstrate that Lgr5 activation of Wnt/b-catenin signaling is a potential mechanism to promote the progression of ESCC and ESCC stem cell renewal, and Lgr5 may be used as a molecular target for the development of treatments for ESCC.	28404917
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSCs) are defined as a rare subpopulation of undifferentiated cells with biological characteristics that include the capacity for self-renewal, differentiation into various lineages, and tumor initiation.	28404917
Extrapulmonary Small Cell Carcinoma, Squamous cell carcinoma of esophagus, Malignant Neoplasms	Stem Cell Exhaustion	To explore the mechanism of CSCs in esophageal squamous cell carcinoma (ESCC), we focused on Leucine-rich repeat containing G protein-coupled receptor 5 (Lgr5), a target gene of the Wnt signaling pathway, which has been identified as a marker of intestinal stem cells and shown to be overexpressed in several human malignancies.	28404917
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Further analyses indicate elevated GLI1 expression is associated with an increase in tumor sphere formation, side population and cell surface markers for putative cancer stem cells.	28404967
Specialty Type - cancer	Stem Cell Exhaustion	We have evidence to support that GLI1 is critical for maintenance of putative cancer stem cells through direct regulation of ABCG2.	28404967
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Iron overload may promote alteration of NK cells and hematopoietic stem/progenitor cells by JNK and P38 pathway in myelodysplastic syndromes.	28405919
PAFAH1B1 wt Allele	Stem Cell Exhaustion	The objective of the study was to examine levels of intracellular iron, reactive oxygen species (ROS) and the expression of JNK and p38MAPK in NK cells and hematopoietic stem/progenitor cells (HSPCs) in MDS patients, and explore potential mechanisms by which iron overload (IOL) promotes MDS progression.	28405919
Cessation of life, Hemopoietic stem cell transplant	Stem Cell Exhaustion	The salvage chemotherapy period was defined as the first chemotherapy hospitalization after the index date to the earliest of death, loss to follow-up, last chemotherapy dose plus 30 days, or initiation of hematological stem cell transplantation (HSCT).	28406385
diabetic	Stem Cell Exhaustion	Effect of Saxagliptin on Circulating Endothelial Progenitor Cells and Endothelial Function in Newly Diagnosed Type 2 Diabetic Patients.	28407661
Antilymphocyte Serum	Stem Cell Exhaustion	Endothelial and Astrocytic Support by Human Bone Marrow Stem Cell Grafts into Symptomatic ALS Mice towards Blood-Spinal Cord Barrier Repair.	28408761
Specialty Type - cancer	Stem Cell Exhaustion	We investigated if cancer stem cells (CSCs) may have a role in pathogenesis of PTCSC.	28411177
Alzheimers Disease	Stem Cell Exhaustion	Characterization of human induced pluripotent stem cell (iPSC) line from a 72year old male patient with later onset Alzheimer's disease.	28413002
Central Diabetes Insipidus, Autosome	Stem Cell Exhaustion	Induced pluripotent stem cells derived from a patient with autosomal dominant familial neurohypophyseal diabetes insipidus caused by a variant in the AVP gene.	28413003
Parkinson Disease	Stem Cell Exhaustion	Derivation of human induced pluripotent stem cell (iPSC) line from a 79year old sporadic male Parkinson's disease patient.	28413004
Specialty Type - cancer	Stem Cell Exhaustion	Differential Ob-R mRNA expression and correlation with cancer stem cell (CSC) markers was evaluated, and correlated with severity.	28414093
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Correlations of the expression levels with the presence of aberrant vessels were analyzed by confocal laser microscopy analysis, using FVIII as endothelial cell marker, CD133 and nestin as cancer stem cell (CSC) marker, CD20 as tumor cell marker, and Stat3.	28415725
Primary central nervous system lymphoma, Neoplasms	Stem Cell Exhaustion	Results showed that in PCNSL, putative endothelial cells lining the vessels are heterogeneous, expressing FVIII/ pStat3/CD133 (presumably originally they are vascular progenitor cells), as well as FVIII/CD20/CD133 (presumably originally they are tumor cells).	28415725
Specialty Type - cancer	Stem Cell Exhaustion	Cluster of differentiation 44 (CD44), an indicator of cancer stem cells, can be specifically targeted by molecular probes and detected in tissues of GC in a large quantity.	28415792
Febrile Neutropenia	Stem Cell Exhaustion	Risk Adapted Management of Febrile Neutrepenia and Early Cessation of Empirical Antibiotherapy in Hematopoietic Stem Cell Transplantation Setting.	28418340
Hematological Disease	Stem Cell Exhaustion	Haematopoietic stem cell transplantation is a curative treatment option for many haematological disorders.	28418340
Communicable Diseases	Stem Cell Exhaustion	Infection following haematopoietic stem cell transplantation is one of the major causes of mortality.	28418340
Neutropenia	Stem Cell Exhaustion	To investigate the outcomes of early cessation of empirical antibiotic treatment per protocol in febrile neutropenia patients who have undergone haematopoietic stem cell transplantation at our clinic.	28418340
Febrile Neutropenia	Stem Cell Exhaustion	The present study retrospectively evaluated febrile neutropenia attacks in haematopoietic stem cell transplantation recipients during the period June 2014 - January 2015 at our haematopoietic stem cell transplantation clinic.	28418340
Childhood Non-Hodgkin Lymphoma, Malignant Neoplasms	Stem Cell Exhaustion	Long-term outcomes, secondary malignancies and stem cell collection following bendamustine in patients with previously treated non-Hodgkin lymphoma.	28419413
Hepatobiliary Disorder	Stem Cell Exhaustion	Liver stem cell therapy (SCT) has been suggested as a promising means to improve liver regeneration in advanced liver disease.	28420441
Protein secretory trypsin inhibitor	Stem Cell Exhaustion	Immunohistochemistry (Ki67, K7, and CD68), in situ hybridization (SPINK1), and global gene expression analysis were performed on liver biopsies (30 control patients and 28 patients with transarterial administration of bone marrow-derived stem cells) both at baseline and after 4 weeks of follow-up.	28420441
Protein secretory trypsin inhibitor, Inflammation, Fibrosis Assessment	Stem Cell Exhaustion	Transcriptome data revealed changes in genes linked with inflammation (CD68 and SAA), regeneration (SPINK1 and HGF), fibrosis (COL1A1), and stem cells (CD45).	28420441
Graft-vs-Host Disease	Stem Cell Exhaustion	Of the former, 12 patients underwent allogeneic hematopoietic stem cell transplantation, and 9 of these patients had graft-versus-host disease (GVHD) before undergoing esophagogastroduodenoscopy (EGD).	28420890
Kidney Failure	Stem Cell Exhaustion	We excluded pregnant women and patients with terminal renal insufficiency or past allogeneic stem cell transplantation.	28421565
Childhood Breast Carcinoma	Stem Cell Exhaustion	Expression of embryonal stem cell transcription factors in breast cancer: Oct4 as an indicator for poor clinical outcome and tamoxifen resistance.	28422735
Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	The relationship between the expression of these markers and clinicopathologic features of the tumors, including breast cancer stem cell phenotype and epithelial-mesenchymal transition marker expression, and their prognostic value in breast cancer, were analyzed.	28422735
Neoplasms	Stem Cell Exhaustion	The transcription factors of embryonic stem cells, such as Oct4, Sox2, Nanog, Bmi1, and Klf4, are known to be associated with stemness, epithelial-mesenchymal transition and aggressive tumor behavior.	28422735
Pleural effusion disorder, Secondary Neoplasm	Stem Cell Exhaustion	Pleural effusions have been shown to be a useful source for studying metastasis and for isolating cells with putative cancer stem cell (CSC) properties.	28423035
Specialty Type - cancer	Stem Cell Exhaustion	Patient-derived aspirates were cultured under sphere forming conditions and isolated primary cultures were further sorted for cancer stem cell subpopulations ALDH1+ and CD44+CD24-/low.	28423035
Childhood Breast Carcinoma, Pleural Effusion, Malignant	Stem Cell Exhaustion	Genetic profiling of putative breast cancer stem cells from malignant pleural effusions.	28423035
Specialty Type - cancer	Stem Cell Exhaustion	However, sequencing based molecular characterization is impeded due to insufficient sensitivity along with a high number of normal contaminating cells, which are masking genetic alterations of rare cancer (stem) cells.	28423035
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Although PRDM14 is elevated in several cancers, it is unclear if and how PRDM14 confers stem cell-like properties and epigenetic changes to cancer cells.	28423353
Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	PRDM14 conferred stem cell-like phenotypes to cancer cells and regulated the expression of genes involved in cancer stemness, metastasis, and chemoresistance.	28423353
Specialty Type - cancer	Stem Cell Exhaustion	Our findings suggest that PRDM14 inhibition may be an effective and novel therapy for cancer stem cells.	28423353
Childhood Breast Carcinoma	Stem Cell Exhaustion	This results in a decreased proliferation of stem/progenitor cells; therefore, the Wnt signaling pathway may represent a potential target for breast cancer prevention in humans.	28423605
Glioblastoma Multiforme Pathway, Malignant Neoplasms	Stem Cell Exhaustion	Here, we investigated the NOS2 mRNA expression by reverse transcription-PCR in human glioma primary cultures at several grade of malignancy and glioma stem cell (GSC) derived neurospheres.	28424427
Glioblastoma Multiforme Pathway, Neoplasms, Aggressive course, Specialty Type - cancer	Stem Cell Exhaustion	NOS2 (inducible nitric oxide synthase) have been proposed as a component of molecular profile of several tumors, including glioma, one of the most aggressive primary brain tumor featuring local cancer stem cells responsible for enhanced resistance to therapies and for tumor recurrence.	28424427
Adenoid Cystic Carcinoma, Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Unlocking the chromatin of adenoid cystic carcinomas using HDAC inhibitors sensitize cancer stem cells to cisplatin and induces tumor senescence.	28426972
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The total sample of 44 AML patients was analyzed on the basis of age <55 and >=55 years, sex, WBC count <50x10/9/l and >=50x10/9/l, the Hb concentration <100 g/l and >=100 g/l, PLT count <100x10/9/l and >=100x10/9/l, Karnofsky score <60% and >60%, cytogenetics, CD56 expression, morphological type and types of treatment (standard and reduced induction chemotherapy, high-dose chemotherapy/stem cell transplantation - autologous and HLA matched, related, allogeneic, together and separately).	28428668
palladium, dendritic lamellar body	Stem Cell Exhaustion	A computational analysis of SNCA 3' untranslated region to identify potential microRNA (miRNA) binding sites and quantitative real-time polymerase chain reaction (PCR) to determine their expression in isogenic induced pluripotent stem cell-derived dopaminergic and cholinergic neurons as a model of PD and DLB, respectively, were performed.	28431219
V-Series Nerve Agent VM, Specialty Type - cancer, Neoplasm Metastasis, Aggressive course, Secondary Neoplasm	Stem Cell Exhaustion	Vasculogenic mimicry (VM, blood supply formation often seen in highly aggressive tumors), Aldehyde dehydrogenase 1 (ALDH1, a biomarker of cancer stem cells), KAI1 (a suppressor gene of tumor metastasis) are all valuable factors for metastasis and prognosis in diverse human cancers.	28431527
Experimental Organism Malignant Hepatocholangiocellular Carcinoma	Stem Cell Exhaustion	Clinicopathological, radiologic, and molecular study of 23 combined hepatocellular-cholangiocarcinomas with stem cell features, cholangiolocellular type.	28431889
Experimental Organism Malignant Hepatocholangiocellular Carcinoma, Carcinoma	Stem Cell Exhaustion	According to the 2010 World Health Organization classification, this carcinoma is a combined hepatocellular-cholangiocarcinoma with stem cell features, cholangiolocellular type (CHC-SC-CLC).	28431889
Glioblastoma Multiforme Pathway, Neoplasms	Stem Cell Exhaustion	Since glioma stem cells (GSCs) have been shown to be more resistant than bulk tumor cells to anti-cancer therapies and to express high levels of these proteins, we also sought to determine if ABCG2 and XIAP have functional roles in GSCs.	28432589
Malignant Neoplasms	Stem Cell Exhaustion	Subsequent malignancies after allogeneic hematopoietic stem cell transplantation.	28432802
Post-transplant lymphoproliferative disorder, Malignant Neoplasms, Lymphoproliferative Disorders	Stem Cell Exhaustion	We evaluated 979 patients for the development of post-transplant lymphoproliferative disease (PTLD) and solid malignancies after allogeneic hematopoietic stem cell transplantations (allo-HSCT) as a late complication.	28432802
Myocardial Ischemia	Stem Cell Exhaustion	Bone marrow (BM)-derived progenitor cells are functionally impaired in patients with ischemic heart disease (IHD), thereby hampering the outcome of autologous stem cell therapy.	28434530
Myocardial Ischemia	Stem Cell Exhaustion	Accelerated replicative senescence is associated with a functional impairment of BM-derived progenitor cells in IHD and could be targeted to improve efficacy of stem cell therapy.	28434530
Myeloid Cell Differentiation, Myocardial Ischemia, Impaired T cell function	Stem Cell Exhaustion	This telomere shortening was associated with reduced myeloid differentiation capacity of BM-MNC, suggesting accelerated senescence as underlying cause for progenitor cell dysfunction in IHD.	28434530
Myocardial Ischemia	Stem Cell Exhaustion	Accelerated cellular senescence as underlying mechanism for functionally impaired bone marrow-derived progenitor cells in ischemic heart disease.	28434530
Primary amyloidosis	Stem Cell Exhaustion	Impact of Autologous Stem Cell Transplantation on the Incidence and Outcome of Oligoclonal Bands in Patients with Light-Chain Amyloidosis.	28434927
Multiple Myeloma	Stem Cell Exhaustion	The emergence of oligoclonal bands (OB) in patients with multiple myeloma achieving a complete remission (CR) after autologous stem cell transplantation (ASCT) and the use of novel agents is a well-recognized event.	28434927
Medial collateral ligament	Stem Cell Exhaustion	We examined our database of 181 consecutive MCL patients who received upfront therapy from 2005 to 2015 with either R-hyperCVAD or less intense chemotherapy (R-bendamustine and R-CHOP only) regimens to assess impact of frontline chemotherapy on collection of hematopoietic cell progenitors before autologous stem cell transplantation (ASCT).	28434928
Mantle cell lymphoma	Stem Cell Exhaustion	Hyperfractionated Cyclophosphamide, Vincristine, Doxorubicin, and Dexamethasone Chemotherapy in Mantle Cell Lymphoma Patients Is Associated with Higher Rates of Hematopoietic Progenitor Cell Mobilization Failure despite Plerixafor Rescue.	28434928
Gigantism	Stem Cell Exhaustion	Dedifferentiation into blastomere-like cancer stem cells via formation of polyploid giant cancer cells.	28436947
Specialty Type - cancer	Stem Cell Exhaustion	Taken together, our findings demonstrate that PGCCs represent somatic equivalents of blastomeres, the most primitive cancer stem cells reported to date.	28436947
Primary central nervous system lymphoma	Stem Cell Exhaustion	High-dose thiotepa-based chemotherapy with autologous stem cell support in elderly patients with primary central nervous system lymphoma: a European retrospective study.	28436974
Primary central nervous system lymphoma	Stem Cell Exhaustion	In this retrospective multicentre study, we investigated the outcomes of elderly primary central nervous system lymphoma (PCNSL) patients (65 years) who underwent high-dose chemotherapy followed by autologous stem cell transplantation (HDT-ASCT) at 11 centres between 2003 and 2016.	28436974
Specialty Type - cancer	Stem Cell Exhaustion	Prominin-1 (Prom1) is a transmembrane glycoprotein, which is expressed in stem cell lineages, and has recently been implicated in cancer stem cell survival.	28437526
Multiple Myeloma	Stem Cell Exhaustion	Efficacy and safety of carfilzomib regimens in multiple myeloma patients relapsing after autologous stem cell transplant: ASPIRE and ENDEAVOR outcomes.	28439109
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) is a standard treatment for eligible multiple myeloma (MM) patients, but many patients will relapse after ASCT and require subsequent therapy.	28439109
Multiple Myeloma	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation (aHSCT) is the recommended standard upfront treatment for transplant eligible myeloma patients.	28439700
Multiple Myeloma	Stem Cell Exhaustion	Filgrastim-alone versus pegylated filgrastim-alone for autologous peripheral blood stem cells mobilization in newly diagnosed multiple myeloma patients.	28439700
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	The efficacy of high-dose cytarabine (HDCA) plus cyclophosphamide/total-body irradiation (CY/TBI) has been proved in cord blood transplantation (CBT) for acute lymphoblastic leukaemia (ALL), but not in bone marrow or peripheral blood stem cell transplantation (BMT/PBSCT).	28439877
Hematologic Neoplasms	Stem Cell Exhaustion	Thus, Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells, suggesting a novel TET2 loss-mediated mechanism of haematological malignancy pathogenesis.	28440315
Myocarditis, CTCAE 5.0	Stem Cell Exhaustion	Human umbilical cord mesenchymal stem cells alleviate acute myocarditis by modulating endoplasmic reticulum stress and extracellular signal regulated 1/2-mediated apoptosis.	28440472
Myocarditis, CTCAE 5.0	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) can alleviate myosin-induced myocarditis; however, the mechanism has not been clearly elucidated.	28440472
Lymphoma	Stem Cell Exhaustion	Methods KEYNOTE-087 ( ClinicalTrials.gov identifier, NCT02453594) was a single-arm phase II study of pembrolizumab in three cohorts of patients with rrHL, defined on the basis of lymphoma progression after (1) autologous stem cell transplantation (ASCT) and subsequent brentuximab vedotin (BV); (2) salvage chemotherapy and BV, and thus, ineligible for ASCT because of chemoresistant disease; and (3) ASCT, but without BV after transplantation.	28441111
Dental Plaque	Stem Cell Exhaustion	Endothelial progenitor cells and plaque burden in stented coronary artery segments: an optical coherence tomography study six months after elective PCI.	28441929
Neoplasms	Stem Cell Exhaustion	Recently, partitioning defective 3-like protein has been demonstrated with tumor-promoting function by disrupting tight junction, inhibiting tumor suppressor liver kinase B1, and maintaining mammary stem cells.	28443499
Sepsis	Stem Cell Exhaustion	Adipose-derived mesenchymal stem cells modulate CD14++CD16+ expression on monocytes from sepsis patients in vitro via prostaglandin E2.	28446249
Sepsis, Inflammation	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) have been shown to reduce sepsis-induced inflammation and improve survival in mouse models of sepsis.	28446249
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GvHD) still belongs to the major challenges after allogeneic hematopoietic stem cell transplantation (HSCT).	28447161
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Consecutive patients, aged 0-18 years, either diagnosed with B cell non-Hodgkin lymphoma (B-NHL) or scheduled for autologous stem cell transplantation (SCT) between April 2015 and September 2016 were included in this study.	28447222
Tears body substance	Stem Cell Exhaustion	The mesenchymal stem cell (MSC)-based tissue engineering approach has been developed to improve the treatment of rotator cuff tears.	28448728
Malignant tumor of cervix	Stem Cell Exhaustion	Hematopoietic stem cell transplant (HSCT) recipients have a higher risk of cervical cancer.	28450182
Adult Glioblastoma	Stem Cell Exhaustion	3a-acetonyltabersonine was cytotoxic to glioblastoma cell lines (U87 and T98G) and stem cells at low concentrations.	28452946
Adult Glioblastoma, Neoplasms	Stem Cell Exhaustion	We verified 3a-acetonyltabersonine could suppress tumor cell proliferation and cause apoptosis in glioblastoma stem cells (GSCs).	28452946
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Percentage of mesenchymal stem cells in high-grade glioma tumor samples correlates with patient survival.	28453745
Glioma	Stem Cell Exhaustion	Human mesenchymal stem cells (hMSCs) have been shown to reside as stromal cells in human gliomas as glioma-associated hMSCs (GA-hMSCs), but their biological role remains unclear.	28453745
herpesvirus 1, human, Forecast of outcome	Stem Cell Exhaustion	Association of the Emergence of Acyclovir-Resistant Herpes Simplex Virus Type 1 With Prognosis in Hematopoietic Stem Cell Transplantation Patients.	28453848
Herpes Simplex Infections	Stem Cell Exhaustion	Antiviral-resistant herpes simplex virus type 1 (HSV-1) has been recognized as an emerging clinical problem among patients undergoing hematopoietic stem cell transplantation (HSCT).	28453848
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We retrospectively analyzed a Japanese nationwide database to elucidate the impact of abnormalities in the short arm of chromosome 17 (abnl[17p]) on the outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with acute myeloid leukemia.	28455005
MS gene	Stem Cell Exhaustion	To summarize the evidence on immunoablative therapy followed by autologous hematopoietic stem cell transplantation (aHSCT) to manage severe and treatment-refractory multiple sclerosis (MS).	28455383
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Moreover, TrkC increased the ability to form tumor spheroids, a property associated with cancer stem cells.	28455963
Bacteremia, Clostridium difficile	Stem Cell Exhaustion	Comparison of the rates of Clostridium difficile and bacteremia after delaying fluoroquinolone prophylaxis from day 0 to day +3 post autologous stem cell transplantation.	28456140
Clostridium difficile colitis, Bacterial Infections, Immunocompromised Host	Stem Cell Exhaustion	Prophylactic fluoroquinolones are routinely administered after stem cell transplantation (SCT) to prevent bacterial infection; however, fluoroquinolones may increase the risk of Clostridium difficile infection, particularly in immunocompromised patients.	28456140
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	NDRG1 promoted stem-like properties of LTICs in NSCLC including iPSC (induced pluripotent stem cell) factors (OCT4, SOX2, KLF4, and C-MYC), the spheres-forming ability and the tumorigenicity of NSCLC.	28456659
Childhood Breast Carcinoma, Neoplasms, Tetranitromethane	Stem Cell Exhaustion	The aim of the study was to evaluate the number of circulating endothelial progenitor cells (circulating EPCs) in the blood of patients diagnosed with breast cancer and to make an attempt at finding associations with the number of circulating EPCs and selected clinic-pathological factors; TNM and histological grading, molecular subtype of breast cancer, hormonal status, the expression of Ki-67 and the size of tumour.	28456778
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Furthermore, our results indicated that verapamil treatment, in combination with carmustine and irradiation, rendered U87MG glioma cells and several patient-derived glioma stem cells more sensitive to therapy-induced senescence than individual or dual-combination treatments.	28459217
Hepatitis B	Stem Cell Exhaustion	Hepatitis B infection acquired after haematopioetic stem cell transplant through horizontal mode.	28460154
Ovarian failure	Stem Cell Exhaustion	Human Mesenchymal Stem Cells Partially Reverse Infertility in Chemotherapy-Induced Ovarian Failure.	28460567
Renal vascular disorder	Stem Cell Exhaustion	Autologous Mesenchymal Stem Cells Increase Cortical Perfusion in Renovascular Disease.	28461553
Angina Pectoris	Stem Cell Exhaustion	Association between echocardiographic epicardial fat thickness and circulating endothelial progenitor cell level in patients with stable angina pectoris.	28464274
Endothelial dysfunction	Stem Cell Exhaustion	Circulating endothelial progenitor cell (EPC) level represents a marker of endothelial dysfunction and vascular health.	28464274
Pancreatitis, Acute	Stem Cell Exhaustion	Endothelial progenitor cells in peripheral blood may serve as a biological marker to predict severe acute pancreatitis.	28465644
Pancreatitis	Stem Cell Exhaustion	To investigate the significance of endothelial progenitor cells (EPCs) in predicting severe acute pancreatitis (SAP).	28465644
Malignant neoplasm of stomach, Specialty Type - cancer, Atypical Glandular Cell	Stem Cell Exhaustion	A previous dose-escalation study of sulfasalazine (SSZ), an inhibitor of cystine-glutamate exchange transporter xc (-), in the variant form of CD44 (CD44v)-positive cancer stem cells (CSCs) suggested that administration of SSZ induces the reduction of CD44v-positive cells and intracellular reduced glutathione (GSH) levels in patients with advanced gastric cancer (AGC).	28466360
Pregnancy Complications, Infectious	Stem Cell Exhaustion	Functionality testing of stem cell grafts to predict infectious complications after allogeneic hematopoietic stem cell transplantation.	28466551
Hematologic Neoplasms, Metabolic Diseases, Primary immune deficiency disorder	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HSCT) is a routine clinical procedure performed to treat patients with haematological malignancies, primary immune deficiencies or metabolic disorders.	28466551
aggressive cancer	Stem Cell Exhaustion	The transcription factor TCF7L1 is an embryonic stem cell signature gene that is upregulated in multiple aggressive cancer types, but its role in skin tumorigenesis has not yet been defined.	28467300
Malignant tumor of colon, Specialty Type - cancer	Stem Cell Exhaustion	Overexpression of IL-37 in colon cancer cell suppressed cell migration, invasion, proliferation, colony formation and cancer stem cells through suppressing b-catenin.	28467774
Specialty Type - cancer	Stem Cell Exhaustion	We performed immunohistochemistry for b-catenin, the hallmark of Wnt activation, and aldehyde dehydrogenase 1 (ALDH1), a putative cancer stem cell marker.	28467793
palladium	Stem Cell Exhaustion	Here, we show that activation of dopamine D1-class receptors elicits a large rhythmic bursting of spontaneous excitatory postsynaptic currents (sEPSCs) in midbrain neurons differentiated from induced pluripotent stem cells (iPSCs) of PD patients with parkin mutations, but not normal subjects.	28467897
Hypercholesterolemia	Stem Cell Exhaustion	Microvascular Function and Endothelial Progenitor Cells in Patients with Severe Hypercholesterolemia and the Familial Hypercholesterolemia Phenotype.	28467991
Family history, Hypercholesterolemia	Stem Cell Exhaustion	To evaluate endothelial progenitor cells (EPCs) and systemic microvascular function in patients with severe hypercholesterolemia, comparing patients with the definite familial hypercholesterolemia (FH) phenotype (DFH) or probable/possible FH phenotype (PFH).	28467991
Neutropenia, Candida (fungus)	Stem Cell Exhaustion	Patients with a history of chemotherapy or stem cell transplantation (SCT) and prolonged neutropenia are at risk for hepatic and/or splenic seeding of Candida.	28469041
Neoplasms	Stem Cell Exhaustion	HSC is not strictly limited to hematologic patients and might also occur in patients with solid tumors treated with intensive chemotherapy or stem cell transplantation.	28469041
Craniosynostosis	Stem Cell Exhaustion	Using a reversible immortalization system expressing SV40 T flanked with FRT sites, we demonstrate that primary human suture progenitor cells derived from the patent sutures of craniosynostosis patients can be efficiently immortalized.	28470873
Lupus Vulgaris	Stem Cell Exhaustion	Bone Marrow-Derived Mesenchymal Stem Cells From Patients With Systemic Lupus Erythematosus Have a Senescence-Associated Secretory Phenotype Mediated by a Mitochondrial Antiviral Signaling Protein-Interferon-b Feedback Loop.	28471483
Lupus Erythematosus, Encephalitis, St. Louis	Stem Cell Exhaustion	Bone marrow-derived mesenchymal stem cells (BM-MSCs) create a special microenvironment for hematopoiesis and immunity and display robust immunomodulatory properties that are impaired in systemic lupus erythematosus (SLE).	28471483
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	We have generated lncRNA expression profiles from the CD34+ haematopoietic stem and progenitor cells (HSPCs) from patients with Myelodysplastic syndromes (MDS) and healthy donors.	28472271
Anaplastic Oligodendroglioma	Stem Cell Exhaustion	Multicenter phase II study of temozolomide and myeloablative chemotherapy with autologous stem cell transplant for newly diagnosed anaplastic oligodendroglioma.	28472509
Multiple Myeloma	Stem Cell Exhaustion	Hispanics have the lowest stem cell transplant utilization rate for autologous hematopoietic cell transplantation for multiple myeloma in the United States: A CIBMTR report.	28472539
Specialty Type - cancer	Stem Cell Exhaustion	By using data from the National Cancer Institute's Surveillance, Epidemiology, and End Results 18 registries, the incidence of MM was calculated, and a stem cell transplantation utilization rate (STUR) was derived.	28472539
Wiskott-Aldrich Syndrome	Stem Cell Exhaustion	Allogeneic stem cell transplant is the only curative treatment for Wiskott-Aldrich syndrome.	28474594
Dengue Fever, Viremia, Hematologic Neoplasms	Stem Cell Exhaustion	Prolonged viremia in dengue virus infection in hematopoietic stem cell transplant recipients and patients with hematological malignancies.	28475281
infectious - Entity Risk	Stem Cell Exhaustion	However, these symptoms are frequently observed in infectious and non-infectious complications of hematopoietic stem cell transplant recipients and oncohematological patients.	28475281
Acute GVH disease, Gastrointestinal tract structure, Therapy-Related Acute Myeloid Leukemia	Stem Cell Exhaustion	We report the case of a 35-year-old man who underwent allogenic stem cell transplantation for a therapy-associated acute myeloid leukemia and developed an acute GvHD with involvement of skin and gastrointestinal tract.	28475513
Extrapulmonary Small Cell Carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Overexpression of CPA4 was closely associated with the putative cancer stem cell marker ALDH1A1 and might be used as an independent prognostic factor in ESCC.	28475748
Specialty Type - cancer	Stem Cell Exhaustion	Nucleostemin (NS)/GNL3 protein has been recently documented to be a nucleolar protein that was abundantly expressed in stem cells and cancer cells.	28476378
Lymphoma	Stem Cell Exhaustion	Phase I/II Study of Intravenous Plerixafor Added to a Mobilization Regimen of Granulocyte Colony-Stimulating Factor in Lymphoma Patients Undergoing Autologous Stem Cell Collection.	28476490
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Plerixafor, given subcutaneously with granulocyte colony-stimulating factor (G-CSF), improves autologous stem cell collection in patients with lymphoma and multiple myeloma.	28476490
Lymphoma	Stem Cell Exhaustion	plerixafor is well tolerated and effective when added to G-CSF for the mobilization of stem cells from patients with lymphoma, with mobilization kinetics and stem cell collections that compare favorably with subcutaneous dosing.	28476490
Osteoporotic Fractures	Stem Cell Exhaustion	Autophagy promotes osteogenic differentiation of human bone marrow mesenchymal stem cell derived from osteoporotic vertebrae.	28476617
Osteoporosis, Senile	Stem Cell Exhaustion	Reduced bone formation caused by senescence is a main cause for senile osteoporosis, however, how to improve the osteogenic differentiation of osteoporotic bone marrow mesenchymal stem cells (BMSCs) remains a challenge.	28476617
Specialty Type - cancer	Stem Cell Exhaustion	The Clinical Significance of Cancer Stem Cell Markers ALDH1A1 and CD133 in Lung Adenocarcinoma.	28476825
Specialty Type - cancer	Stem Cell Exhaustion	Aldehyde dehydrogenase-1A1 (ALDH1A1) and CD133 have been identified as markers of cancer stem cells (CSCs).	28476825
Communicable Diseases	Stem Cell Exhaustion	Dental status does not predict infection during stem cell transplantation: a single-center survey.	28481351
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Biological markers for risk stratification of chronic GvHD (cGvHD) could improve the care of patients undergoing allogeneic hematopoietic stem cell transplantation.	28481353
Degenerative polyarthritis	Stem Cell Exhaustion	A consistent and potentially exploitable response during chondrogenesis of mesenchymal stem cells from osteoarthritis patients to the protein encoded by the susceptibility gene GDF5.	28481944
HD Term Type, FAP protein, human	Stem Cell Exhaustion	HD-derived CD14 + monocytes and induced pluripotent stem cell-derived myeloid lineage cells from a HD and FAP patient dose-dependently produced IL-6 under mutated and aggregated TTR conditions, compared with wild-type TTR.	28484271
Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	A randomized phase II study of standard-dose versus high-dose rituximab with BEAM in autologous stem cell transplantation for relapsed aggressive B-cell non-hodgkin lymphomas: long term results.	28485023
Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	High-dose rituximab (HD-R) combined with carmustine, cytarabine, etoposide and melphalan (BEAM) and autologous stem cell transplant (ASCT) was effective and tolerable in a single-arm prospective study of relapsed aggressive B-cell non-Hodgkin lymphoma (R-NHL).	28485023
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Myelodysplastic syndrome is characterized by stem-cell-derived clonal myelopoiesis with an alteration in proliferation and differentiation.	28488979
Malignant Neoplasms	Stem Cell Exhaustion	CPAM type 2-derived mesenchymal stem cells: Malignancy risk study in a 14-month-old boy.	28493304
Neoplasms	Stem Cell Exhaustion	Interactions between the tumor, immune, and mesenchymal stromal/stem cells (MSCs) have been recognized as crucial for understanding tumorigenesis.	28493304
Prostate carcinoma	Stem Cell Exhaustion	Mesenchymal Stem Cells (MSCs) have been identified in prostate cancer, raising the critical question of their physical and temporal source.	28493842
Prostate carcinoma	Stem Cell Exhaustion	In contrast to lineage-restricted Mesenchymal Progenitor Cells (MPCs) found in normal prostate tissue, MSCs with tri-lineage differentiation potential (adipogenesis, osteogenesis, and chondrogenesis) are identified in prostate tissue from a subset of men with prostate cancer, consistent with an influx of more stem-like progenitors (i.e.	28493842
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	In patients with chronic lymphocytic leukemia (CLL), persistence of disease after allogeneic stem cell transplantation (alloSCT) can result in poor outcomes.	28495642
Crohn Disease	Stem Cell Exhaustion	Autologous stem-cell transplantation in treatment-refractory Crohn's disease: an analysis of pooled data from the ASTIC trial.	28497755
Gastrointestinal inflammation, Crohn Disease	Stem Cell Exhaustion	The randomised controlled ASTIC trial showed no benefit of mobilisation and autologous haematopoietic stem-cell transplantation (HSCT) compared with mobilisation followed by conventional therapy using a stringent primary endpoint (steroid-free clinical remission for 3 months with no endoscopic or radiological evidence of intestinal inflammation) in patients with treatment-refractory Crohn's disease.	28497755
Endometrial Carcinoma	Stem Cell Exhaustion	Increased Endothelial Progenitor Cell Number in Early Stage of Endometrial Cancer.	28498245
Endometrial Carcinoma	Stem Cell Exhaustion	Endothelial progenitor cell numbers (CD34, VEGFR2/KDR) in the peripheral blood of women with endometrial carcinoma were significantly augmented as compared with those of control healthy women and CEC numbers (CD31, CD45) were similar in both groups.	28498245
Tissue damage	Stem Cell Exhaustion	With this background, the aim of this study is firstly to examine the impact of a selective centrifugation on existing adipose stem cells (ASCs) in terms of stemness profile maintenance and, secondly, to investigate the effect of restoring volume in reconstruction on patients affected by soft tissue damage.	28498335
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic Hematopoietic Stem Cell Transplantation for Adolescents and Young Adults with Acute Myeloid Leukemia.	28501543
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Few reports have focused on adolescent and young adult (AYA) patients with acute myeloid leukemia (AML) treated with hematopoietic stem cell transplantation (HSCT).	28501543
Encephalitis, Hyponatremia	Stem Cell Exhaustion	Hyponatremia associated with human herpesvirus-6 (HHV-6) encephalitis after allogeneic hematopoietic stem cell transplantation: A presentation different from HHV-6 myelitis.	28501929
Encephalitis, Myelitis	Stem Cell Exhaustion	Human herpesvirus-6 (HHV-6) encephalitis and myelitis following allogeneic hematopoietic stem cell transplantation (HSCT) is frequently life-threatening.	28501929
Antiphospholipid Syndrome, Mucosa-Associated Lymphoid Tissue Lymphoma	Stem Cell Exhaustion	Successful Treatment of Catastrophic Antiphospholipid Antibody Syndrome Associated with MALT Lymphoma by Autologous Hematopoietic Stem Cell Transplantation.	28502938
Lymphoma	Stem Cell Exhaustion	One month later, the CAPS and lymphoma relapsed, and the patient underwent autologous hematopoietic stem cell transplantation.	28502938
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We studied the effect of IA on mortality in 167 consecutive patients starting with remission-induction therapy for AML or of whom most patients continued to haematopoietic stem cell transplantation (HSCT).	28504663
Specialty Type - cancer	Stem Cell Exhaustion	Recent advances in single-cell transcriptomics are ideally placed to unravel intratumoral heterogeneity and selective resistance of cancer stem cell (SC) subpopulations to molecularly targeted cancer therapies.	28504724
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia.	28504724
Malignant neoplasm of stomach	Stem Cell Exhaustion	Immunohistochemical analysis of a panel of primitive phenotypic markers, including embryonic stem cell markers (OCT4, NANOG, SALL4, CLDN6, and LIN28) and known oncofetal proteins (AFP and GPC3), was performed using tissue microarray on 386 gastric cancers.	28505005
SLC26A3 wt Allele, Specialty Type - cancer, Chronic lung disease, Hematologic Neoplasms, HIV Infections	Stem Cell Exhaustion	The study population included 116 patients, 37.9% of whom had haematological malignancy or underwent haematological stem cell transplantation (HSCT), 22.4% had HIV infection, 16.4% had chronic lung diseases (CLD), 7.8% had a solid cancer, and 3.4% underwent a solid organ transplant (SOT).	28505159
Graft-vs-Host Disease, Chronic graft-versus-host disease, Autoimmune Disorder, CTCAE	Stem Cell Exhaustion	Chronic graft-versus-host disease (GVHD) appears several months following allogenic hematopoietic stem cell transplantation (HSCT) and is clinically analogous to autoimmune disorder.	28506261
Carcinoma, Specialty Type - cancer, Neoplasms, Secondary Neoplasm, Carcinogenesis	Stem Cell Exhaustion	As a cancer stem cell marker, CD44 variant 6 (CD44v6) has been implicated in carcinogenesis, tumor progression, and metastasis in a variety of human carcinomas.	28507278
herpesvirus 3, human	Stem Cell Exhaustion	Duration of Antiviral Prophylaxis and Risk of Herpes Zoster among Patients Receiving Autologous Hematopoietic Stem Cell Transplants: A Retrospective, Observational Study.	28508307
herpesvirus 3, human	Stem Cell Exhaustion	There are no real-world data on antiviral prophylaxis (AP) duration and risk of herpes zoster (HZ) given AP duration in patients receiving autologous hematopoietic stem cell transplants (auto-HSCT).	28508307
HLA Mismatch, Hematologic Neoplasms	Stem Cell Exhaustion	No effect of HLA-C mismatch after allogeneic hematopoietic stem cell transplantation with unrelated donors and T-cell depletion in patients with hematological malignancies.	28510343
HLA Mismatch	Stem Cell Exhaustion	HLA-C mismatch in unrelated donor's hematopoietic stem cell transplantation (HSCT) has been associated with poor patient outcome.	28510343
Rheumatoid Arthritis, Degenerative polyarthritis	Stem Cell Exhaustion	Yields and chondrogenic potential of primary synovial mesenchymal stem cells are comparable between rheumatoid arthritis and osteoarthritis patients.	28511664
Chromothripsis	Stem Cell Exhaustion	We also found a novel fusion involving USP9X-ERAS formed by chromothripsis and leading to high expression of ERAS, a constitutively active RAS protein normally expressed only in embryonic stem cells.	28512242
Hodgkin Disease	Stem Cell Exhaustion	Outcomes of patients with relapsed/refractory Hodgkin lymphoma progressing after autologous stem cell transplant in the current era of novel therapeutics: A retrospective analysis.	28512788
Hodgkin Disease	Stem Cell Exhaustion	Patients with relapsed/refractory Hodgkin lymphoma (RR-HL) who progress or relapse following autologous stem cell transplantation (ASCT) have historically had a poor prognosis.	28512788
Multiple Myeloma	Stem Cell Exhaustion	Outcome of autologous hematopoietic stem cell transplantation in refractory multiple myeloma.	28513828
Multiple Myeloma	Stem Cell Exhaustion	Patients with refractory myeloma who underwent first autologous hematopoietic stem cell transplantation (auto-HCT) between March 2000 and October 2015 were retrospectively analyzed.	28513828
Neoplasms	Stem Cell Exhaustion	We established the neuroendocrine tumor sphere cell line ANI-27S, which displayed stable exponential growth, virtually unlimited expansion in vitro, and expression of stem-cell markers such as CD133, nestin, Sox2, and aldehyde dehydrogenase.	28516286
Liver Neuroendocrine Tumor	Stem Cell Exhaustion	For the first time, we demonstrated the presence of a sphere-forming, stem cell-like population in brain metastases from a primary neuroendocrine tumor.	28516286
Neuroendocrine Tumors, Specialty Type - cancer	Stem Cell Exhaustion	Neuroendocrine tumors are rare, and little is known about the existence of cancer stem cells in this disease.	28516286
leukemia	Stem Cell Exhaustion	Disulfiram/copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-kB and Nrf2.	28518151
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Leukemia stem cells (LSCs) is the major cause of the recurrence of AML even after aggressive treatment making, promoting development of LSC-targeted agents is an urgent clinical need.	28518151
Hematologic Neoplasms, Neoplasms, Specialty Type - cancer, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Although the antitumor activity of disulfiram (DS), an approved anti-alcoholism drug, has been demonstrated in multiple types of tumors including hematological malignancies such as AML, it remains unknown whether this agent would also be able to target cancer stem cells like LSCs.	28518151
Pseudomonas aeruginosa	Stem Cell Exhaustion	Control of Multidrug-Resistant Pseudomonas aeruginosa in Allogeneic Hematopoietic Stem Cell Transplant Recipients by a Novel Bundle Including Remodeling of Sanitary and Water Supply Systems.	28520856
Pseudomonas aeruginosa, Infection	Stem Cell Exhaustion	Infections by multidrug-resistant Pseudomonas aeruginosa (MDRPa) are an important cause of morbidity and mortality in patients after allogeneic hematopoietic stem cell transplantation (HSCT).	28520856
Meibomian gland dysfunction	Stem Cell Exhaustion	Evaluation of endocrine and metabolic dysfunctions after hematopoietic stem cell transplantation in children: a study from Turkey.	28525352
Complication Aspects	Stem Cell Exhaustion	The objective of the study was to evaluate endocrine and metabolic complications after hematopoietic stem cell transplantation (HSCT) in children.	28525352
Multiple Myeloma	Stem Cell Exhaustion	Efficacy and safety of plerixafor for the mobilization/collection of peripheral hematopoietic stem cells for autologous transplantation in Japanese patients with multiple myeloma.	28527129
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	To evaluate the efficacy and safety of plerixafor for the mobilization/collection of peripheral hematopoietic stem cells (HSCs) for autologous transplantation in Japanese patients with multiple myeloma (MM).	28527129
Specialty Type - cancer	Stem Cell Exhaustion	Between September 2011 and February 2014, 126 pediatric cancer patients were admitted to our center for chemotherapy and/or hematopoietic stem cell transplantation and were included in this study.	28527651
Comorbidity, Relapsing course	Stem Cell Exhaustion	Long-Term Follow-Up and Impact of Comorbidity before Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Relapsed or Refractory Acute Myeloid Leukemia-Lessons Learned from the Prospective BRIDGE Trial.	28527985
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	In patients with relapsed or refractory (r/r) acute myeloid leukemia (AML), allogeneic hematopoietic stem cell transplantation (HSCT) is considered to be the only treatment providing long-term disease control.	28527985
Colonization	Stem Cell Exhaustion	Clinical Impact of Colonization with Multidrug-Resistant Organisms on Outcome after Autologous Stem Cell Transplantation: A Retrospective Single-Center Study.	28528711
Multi-Drug Resistant Organism	Stem Cell Exhaustion	To determine the impact of colonization with MDRO on overall survival, we retrospectively analyzed data from patients undergoing autologous hematopoietic stem cell transplantation at our institution.	28528711
Hematologic	Stem Cell Exhaustion	139 haematological cancer patients who underwent a stem cell transplantation completed a longitudinal questionnaire according to 3 phases of the treatment: short-term (pre-transplant), medium-term (1st year post-transplant) and long-term (2nd-6th year post-transplant).	28529098
Specialty Type - cancer	Stem Cell Exhaustion	Tumour-initiating cells, or cancer stem cells (CSCs), possess stem-cell-like properties observed in normal adult tissue stem cells.	28530657
Lymphoma, Follicular, Lymphoma	Stem Cell Exhaustion	Radioimmunotherapy-augmented BEAM chemotherapy vs BEAM alone as the high-dose regimen for autologous stem cell transplantation (ASCT) in relapsed follicular lymphoma (FL): a retrospective study of the EBMT Lymphoma Working Party.	28530668
Lymphoma, Follicular, Failure	Stem Cell Exhaustion	Relapse remains the most common cause of treatment failure in patients receiving autologous stem cell transplantation (ASCT) for follicular lymphoma (FL).	28530668
Hematologic Neoplasms	Stem Cell Exhaustion	High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is frequently performed in patients with hematologic malignancies.	28533058
Lymphoma, Follicular	Stem Cell Exhaustion	Autologous Stem Cell Transplantation for Follicular Lymphoma: Favorable Long-Term Survival Irrespective of Pretransplantation Rituximab Exposure.	28533060
Lymphoma, Follicular	Stem Cell Exhaustion	High-dose chemotherapy supported by autologous stem cell transplantation (HDT/ASCT) has contributed to modify the natural history of follicular lymphoma (FL); however, an overall survival (OS) benefit has been demonstrated at relapse only after a rituximab-free chemotherapy regimen.	28533060
Huntingtons Disease Pathway	Stem Cell Exhaustion	KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.	28533375
Specialty Type - cancer, Squamous cell carcinoma of esophagus	Stem Cell Exhaustion	Enhanced cancer stem cell properties of a mitotically quiescent subpopulation of p75NTR-positive cells in esophageal squamous cell carcinoma.	28534989
Specialty Type - cancer	Stem Cell Exhaustion	Mitotically quiescent cancer stem cells (CSCs) possess higher malignant potential than other CSCs, indicating their higher contribution to therapeutic resistance than that of other CSCs.	28534989
Mantle cell lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) in patients with mantle cell lymphoma: a retrospective study of the Spanish lymphoma group (GELTAMO).	28536895
Left ventricular aneurysm, Perforation (observation)	Stem Cell Exhaustion	As the field of stem cell therapy evolves and the use of this technique increases, operators must be aware that the presence of an LV aneurysm may increase the risk of perforation during a NOGA mapping procedure.	28539211
Left ventricular aneurysm, Perforation (observation)	Stem Cell Exhaustion	We present the case of a woman who developed a perforation at the site of an LV aneurysm during NOGA mapping prior to the transendocardial injection of stem cells, as part of a multicenter clinical trial.	28539211
Childhood Breast Carcinoma	Stem Cell Exhaustion	Purpose: Chemokine receptor 1 (CXCR1) is recognized as an actionable receptor selectively expressed by breast cancer stem cells (BCSCs).	28539464
leukemia, Myeloid-Lymphoid Leukemia Protein	Stem Cell Exhaustion	Because of the poor prognosis linked to these leukemias, the patient benefited from chemotherapy targeting both myeloid and lymphoid components, followed by allogeneic hematopoietic stem cell transplantation.	28540857
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Clinical impact of pretransplant use of multiple tyrosine kinase inhibitors on the outcome of allogeneic hematopoietic stem cell transplantation for chronic myelogenous leukemia.	28543934
Failure	Stem Cell Exhaustion	Therefore, allogeneic hematopoietic stem cell transplantation (allo-HSCT) is considered only for patients with disease progression or for patients after treatment failure with multiple TKIs.	28543934
Disease, Malignant Peripheral Nerve Sheath Tumor, Primary Myelofibrosis, leukemia	Stem Cell Exhaustion	BCR-ABL1-negative myeloproliferative neoplasms (MPNs) are clonal stem cell disorders defined by proliferation of one or more myeloid lineages, and carry an increased risk of vascular events and progression to myelofibrosis and leukemia.	28543980
Inflammation, Hypertensive (finding), Vascular System Injuries	Stem Cell Exhaustion	Kallistatin, an endogenous protein, protects against vascular injury by inhibiting oxidative stress and inflammation in hypertensive rats and enhancing the mobility and function of endothelial progenitor cells (EPCs).	28544111
Viral respiratory infection	Stem Cell Exhaustion	Here we report the applicability of a protocol based on clinical conditions and risk factors (RFs) for managing 35 allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients who developed a total of 52 episodes of respiratory viral infections (RVIs) caused by respiratory syncytial virus (RSV; n=19), human parainfluenza virus (HPIV; n=29), or both (n=4) over a 2-year study period.	28544152
Specialty Type - cancer	Stem Cell Exhaustion	Emergence of CD26+ Cancer Stem Cells with Metastatic Properties in Colorectal Carcinogenesis.	28545226
Colorectal Carcinoma, Secondary Neoplasm	Stem Cell Exhaustion	A subpopulation of CD26+ colorectal cancer stem cells are known to be implicated in metastasis.	28545226
Specialty Type - cancer, Neoplasms, Carcinogenesis	Stem Cell Exhaustion	We hypothesized that this subpopulation of cancer stem cells arises in the late stage of carcinogenesis from the bulk of tumor daughter cells which are CD26-.	28545226
Colorectal Carcinoma, Neoplasms	Stem Cell Exhaustion	These findings shed light to the origin of colorectal cancer stem cells with metastatic properties, which has an implication on conventional treatments by surgery or adjuvant chemotherapy for tumor debulking.	28545226
Neoplasms, Central neuroblastoma	Stem Cell Exhaustion	Neuroblastoma is the most common solid tumor in childhood and develops from undifferentiated progenitor cells of the sympathetic nervous system.	28545464
Specialty Type - cancer, Carcinoma, Ovarian Epithelial, Neoplasms	Stem Cell Exhaustion	The existence of cancer stem cells (CSCs) within a tumor bulk has been demonstrated for many solid tumors including epithelial ovarian carcinoma (EOC).	28545541
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GvHD) is a major complication of allogeneic stem cell transplantation.	28547857
Acute lymphocytic leukemia	Stem Cell Exhaustion	Haploidentical allogeneic hematopoietic stem cell transplantation compared to matched unrelated transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia.	28549237
B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1, BCR gene	Stem Cell Exhaustion	To investigate the effect of haploidentical allogeneic hematopoietic stem cell transplantation (Haplo-HCT) in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL), the outcome of 58 patients with Ph+ ALL who received Haplo-HCT (n=42) or matched unrelated donor transplantation (MUD-HCT) (n=16) during the same period were analyzed retrospectively.	28549237
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GVHD) hampers the utility of allogeneic hematopoietic stem cell transplantation (AHSCT).	28549771
Fever	Stem Cell Exhaustion	HHV-6 reactivation as a cause of fever in autologous hematopoietic stem cell transplant recipients.	28551368
Lymphoma	Stem Cell Exhaustion	We report the biological and clinical impacts possibly associated with HHV-6 reactivation in autologous hematopoietic stem cell transplant (AHSCT) recipients after intensive chemotherapy regimen for lymphoma.	28551368
Neoplasms	Stem Cell Exhaustion	Stem cell marker MELK was noted to stain both the neoplastic ependymal and ganglionic components, possibly suggesting a stem cell/progenitor origin for the tumor with subsequent divergent differentiation.	28554236
Photoreceptor degeneration	Stem Cell Exhaustion	Pluripotent stem cells and their utility in treating photoreceptor degenerations.	28554397
retinal development	Stem Cell Exhaustion	Driven in large part by the requirement for renewable cell sources, stem cells have emerged not only as a promising source of replacement photoreceptors but also to provide in vitro systems with which to study retinal development and disease processes and to test therapeutic agents.	28554397
Diabetes	Stem Cell Exhaustion	Electrical Muscle Stimulation Induces an Increase of VEGFR2 on Circulating Hematopoietic Stem Cells in Patients With Diabetes.	28554530
physiopathological, Hyperglycemia, Inflammation	Stem Cell Exhaustion	The inflammation and oxidative stress of bone marrow-derived proangiogenic cells (PACs), also named endothelial progenitor cells, triggered by hyperglycemia contributes significantly to vascular dysfunction.	28555162
Multiple Myeloma	Stem Cell Exhaustion	Poor peripheral blood stem cell mobilization affects long-term outcomes in multiple myeloma patients undergoing autologous stem cell transplantation.	28556233
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Peripheral blood stem cell (PBSC) mobilization is routinely undertaken prior to autologous stem cell transplantation (ASCT) in patients with multiple myeloma (MM).	28556233
leukemia, Acute lymphocytic leukemia	Stem Cell Exhaustion	Unmanipulated haploidentical stem cell transplantation in adults with acute lymphoblastic leukemia: a study on behalf of the Acute Leukemia Working Party of the EBMT.	28558762
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	Allogenic hematopoietic stem cell transplantation (allo-SCT) is the most effective post-remission treatment for adults with high-risk acute lymphoblastic leukemia (ALL).	28558762
Glioblastoma Multiforme Pathway, Adult Glioblastoma	Stem Cell Exhaustion	Stemness Marker Detection in the Periphery of Glioblastoma and Ability of Glioblastoma to Generate Glioma Stem Cells: Clinical Correlations.	28559081
Glioblastoma Multiforme Pathway, Glioblastoma	Stem Cell Exhaustion	Recent studies suggested glioma stem cells (GSCs) are key contributors to therapeutic resistance of glioblastoma multiforme (GBM) and are responsible for GBM recurrence.	28559081
Hemorrhagic cystitis	Stem Cell Exhaustion	Viral-induced Hemorrhagic Cystitis After Allogeneic Hematopoietic Stem Cell Transplant.	28559150
CLTC gene, Hemorrhagic cystitis	Stem Cell Exhaustion	Hemorrhagic cystitis (HC) is a well-recognized problem that is regularly observed after hematopoietic stem cell transplantation (HSCT).	28559150
Primary central nervous system lymphoma	Stem Cell Exhaustion	High-dose chemotherapy with autologous haematopoietic stem cell support for relapsed or refractory primary CNS lymphoma: a prospective multicentre trial by the German Cooperative PCNSL study group.	28559537
Primary central nervous system lymphoma	Stem Cell Exhaustion	To investigate safety and efficacy of high-dose chemotherapy followed by autologous stem cell transplantation (HCT-ASCT) in relapsed/refractory (r/r) primary central nervous system lymphoma (PCNSL), we conducted a single-arm multicentre study for immunocompetent patients (<66 years) with PCNSL failing high-dose methotrexate)-based chemotherapy.	28559537
Hepatic Veno-Occlusive Disease, Spondylo-ocular syndrome	Stem Cell Exhaustion	Sinusoidal obstruction syndrome (SOS) is a life-threatening complication of hematopoietic stem cell transplantation (HSCT) associated with significant morbidity and mortality.	28562132
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	For relapsed or elderly MDS and AML patients ineligible for hematopoietic stem cell transplantation, epigenetic therapies, including DNA methyltransferase inhibitors and histone deacetylase inhibitors, have been utilized as palliative therapy, offering a well-tolerated approach to disease stabilization, prolonged survival, and quality of life.	28562519
Bone Marrow Diseases, Neoplasms	Stem Cell Exhaustion	Both patients were ineligible for hematopoietic stem cell transplantation due to concurrent solid tumor relapse, but were treated with the epigenetic combination therapy, decitabine and vorinostat, and achieved stabilization of marrow disease, outpatient palliation, and family-reported reasonable quality of life.	28562519
Liver carcinoma, Hepatitis B	Stem Cell Exhaustion	Hepatitis B virus X protein induces hepatic stem cell-like features in hepatocellular carcinoma by activating KDM5B.	28566884
Liver carcinoma, Hollings Cancer Center, Hepatitis B	Stem Cell Exhaustion	To determine the role of hepatitis B virus X protein (HBx), HBx in regulating hepatic progenitor cell (HPC)-like features in hepatocellular carcinoma (HCC) and the underlying molecular mechanisms.	28566884
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The aim of this study was to evaluate whether blood transfusions affect overall survival (OS) and progression-free survival (PFS) in newly diagnosed multiple myeloma (MM) patients without hematopoietic stem cell transplantation.	28567420
Cartilage	Stem Cell Exhaustion	In vitro cultured autologous mesenchymal stem cells (MSCs) within passage 5 have been approved for clinical application in stem cell-based treatment of cartilage defects.	28569773
Cartilage	Stem Cell Exhaustion	In vitro expansion impaired the stemness of early passage mesenchymal stem cells for treatment of cartilage defects.	28569773
teratologic	Stem Cell Exhaustion	This result indicates that telomerase and chromosome anomalies might originate from expansion, leading to impaired stemness and pluripotency of stem cells.	28569773
Anemia, Sickle Cell, Toxic effect	Stem Cell Exhaustion	Reduced toxicity, myeloablative HLA-haploidentical hematopoietic stem cell transplantation with post-transplantation cyclophosphamide for sickle cell disease.	28573314
Anemia, Sickle Cell, Renal carnitine transport defect	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HSCT) offers the possibility of cure for sickle cell disease (SCD) patients.	28573314
Failure	Stem Cell Exhaustion	Failure to achieve CR with induction therapy, and age >65 years are associated with poor outcomes in MS. Allogeneic stem-cell transplant in first remission appears to be the most effective modality for achieving long-term remissions.	28574302
Aleukemic leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Despite the heterogeneity of acute myeloid leukemia (AML), overexpression of the interleukin-3 receptor-a (CD123) on both the more differentiated leukemic blast and leukemic stem cells (LSCs) provides a therapeutic target for antibody treatment.	28574487
Squamous cell carcinoma	Stem Cell Exhaustion	Chemokine (CC motif) ligand 18 upregulates Slug expression to promote stem-cell like features by activating the mammalian target of rapamycin pathway in oral squamous cell carcinoma.	28574664
Specialty Type - cancer	Stem Cell Exhaustion	In conclusion, our data suggested that CCL18 upregulated Slug expression to promote EMT and stem cell-like features by activating the mTOR pathway in oral cancer.	28574664
Specialty Type - cancer, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	The cancer stem cell (CSC) hypothesis considers CSCs to be the main culprits in driving tumor initiation, metastasis, and resistance to conventional therapy.	28574829
Malignant tumor of colon	Stem Cell Exhaustion	Previous evidence has shown that high-calorie diet (HCD) enhances colonic stem cell numbers and expansion of the proliferative zone, an important biomarker for colon cancer.	28576788
Zygomycosis, Cunninghamella bertholletiae, Communicable Diseases	Stem Cell Exhaustion	Infection caused by Cunninghamella bertholletiae carries one of the highest mortality rates among mucormycosis, and there are no reported cases that survived from the infection in allogeneic hematopoietic stem cell transplantation recipients occurring before neutrophil engraftment.	28577122
Osteoporosis	Stem Cell Exhaustion	A biophysical approach to quantify skeletal stem cells trans-differentiation as a model for the study of osteoporosis.	28578832
Cytomegalovirus Infections	Stem Cell Exhaustion	When should preemptive antiviral therapy for active CMV infection be withdrawn from allogeneic stem cell transplant recipients?	28581458
Leukemia, Myelocytic, Acute, NPM1 wt Allele	Stem Cell Exhaustion	Dynamics of molecular response in AML patients with NPM1 and FLT3 mutations undergoing allogeneic stem cell transplant.	28581462
Neurotoxicity Syndromes	Stem Cell Exhaustion	Attempts to improve efficacy and reduce neurotoxicity of consolidation therapy have included thiotepa-based high-dose chemotherapy and autologous stem cell transplant (HDC-ASCT).	28581466
Neoplasms	Stem Cell Exhaustion	Administration of high-dose chemotherapy with stem cell support in patients 40 years of age or older with advanced germ cell tumours: a retrospective study from the European Society for Blood and Marrow Transplantation database.	28581469
Hematologic Neoplasms	Stem Cell Exhaustion	Allogeneic stem cell transplantation (allo-SCT) with or without donor lymphocyte infusions (DLI) is the only curative option for several hematological malignancies.	28581468
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic GvHD (cGvHD) is the leading cause of late non-relapse mortality (NRM) and morbidity after allogeneic hematopoietic stem cell transplant (AHSCT).	28581472
Hodgkin Disease	Stem Cell Exhaustion	Brentuximab vedotin consolidation post-autologous stem cell transplant in Hodgkin lymphoma patients at risk of residual disease: number needed to treat.	28583027
NNT gene	Stem Cell Exhaustion	The number needed to treat (NNT) with brentuximab vedotin consolidation therapy post-autologous stem cell transplant (ASCT) versus placebo in the phase 3 AETHERA trial to avoid one additional event of disease progression/death was evaluated.	28583027
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	The pivotal LYM-3002 study compared frontline rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) with bortezomib, rituximab, cyclophosphamide, doxorubicin and prednisone (VR-CAP) in newly diagnosed mantle cell lymphoma (MCL) patients for whom stem cell transplantation was not an option.	28583031
Lymphoma, Non-Hodgkin, Multiple Myeloma	Stem Cell Exhaustion	Patients who underwent hematopoietic stem cell transplantation for multiple myeloma had a significantly higher 5-year mortality rate (100%) compared with patients who had an underlying diagnosis of non-Hodgkin's lymphoma (0%) (P=.008).	28585995
Perianal abscess	Stem Cell Exhaustion	Perianal abscess developed in various phases of treatment and in the stem cell transplantation period.	28586772
Graft-vs-Host Disease	Stem Cell Exhaustion	Extracorporeal photopheresis for GVHD prophylaxis after reduced intensity conditioning allogeneic hematopoietic stem cell transplantation: a prospective multicenter phase 2 study.	28587506
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	The best approach for allogeneic haematopoietic stem cell transplantations (alloHCT) in patients with chronic lymphocytic leukaemia (CLL) is unknown.	28589551
Opportunistic Infections	Stem Cell Exhaustion	Are the Polyomaviruses BK and JC Associated with Opportunistic Infections, Graft-versus-Host Disease, or Worse Outcomes in Adult Patients Receiving Their First Allogeneic Stem Cell Transplantation with Low-Dose Alemtuzumab?	28591758
Graft-vs-Host Disease, Opportunistic Infections	Stem Cell Exhaustion	The association of polyomaviruses BK and JC with other opportunistic infections and graft-versus-host disease (GvHD) in allogeneic stem cell transplantation is controversially discussed.	28591758
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation for acute myeloid leukemia - single center experience.	28592126
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We aimed to determine the effect of autologous hematopoietic stem cell transplantation (auto-HSCT) on acute myeloid leukemia (AML) patients as a valid alternative therapeutic option for patients without HLA-compatible donor.	28592126
Malignant neoplasm of stomach, Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	Predictive value for lymph node metastasis of epithelial-mesenchymal transition and cancer stem cell marker expression in early gastric cancer.	28595915
Malignant neoplasm of stomach, Secondary Neoplasm	Stem Cell Exhaustion	In the present study, the significance of epithelial mesenchymal transition and stem cell marker expression in lymph node metastasis in early gastric cancer was investigated.	28595915
Malignant neoplasm of stomach	Stem Cell Exhaustion	We evaluated the significance of the expression of 5 epithelial mesenchymal transition-related markers (E-cadherin, MMP7, S100A, Snail-1, and HGF) and 6 stem cell markers (ALDH1, SOX2, CD24, CD44, CD54, and CD133) in 119 early gastric cancer specimens using immunohistochemistry.	28595915
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	In chronic myeloid leukemia, resistance against BCR-ABL1 tyrosine kinase inhibitors can develop because of BCR-ABL1 mutations, activation of additional pro-oncogenic pathways, and stem cell resistance.	28596283
Sample Size Calculation	Stem Cell Exhaustion	We treated them by fat grafting, rich in adipose stem cells, and we evaluated through time clinical, functional and aesthetic evaluation of oral pathology associated with SSc.	28597066
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease was reported in 25/42 patients who received mogamulizumab before allogeneic hematopoietic stem cell transplantation.	28597329
Hodgkin Disease	Stem Cell Exhaustion	We report on a 30-year-old man with stage IVB Hodgkin lymphoma, who failed nine lines of treatments including high-dose chemotherapy and autologous stem cell transplantation and brentuximab vedotin.	28597713
GCLC protein, human, Lymphoma, Non-Hodgkin, Shock, Respiratory Failure	Stem Cell Exhaustion	By multivariate analysis, factors independently associated with higher hospital mortality were poor performance status (odds ratio [OR], 3.99; 95%CI, 1.82-9.39; P = 0.0009), non-Hodgkin's lymphoma (OR, 2.60; 95%CI, 1.35-5.15; P = 0.005), shock (OR, 1.95; 95%CI, 1.04-3.72; P = 0.04), and respiratory failure (OR, 2.18; 95%CI, 1.14-4.25; P = 0.02); and factors independently associated with lower hospital mortality were GCS score on day 1 (OR, 0.88/point; 95%CI, 0.81-0.95; P = 0.0009) and autologous stem cell transplantation (OR, 0.25; 95%CI, 0.07-0.75; P = 0.02).	28598990
Teratoma	Stem Cell Exhaustion	Brief Report: External Beam Radiation Therapy for the Treatment of Human Pluripotent Stem Cell-Derived Teratomas.	28600830
Teratoma	Stem Cell Exhaustion	Taken together, these results provide proof of concept for the use of EBRT in the treatment of existing teratomas and highlight a strategy to increase the safety of stem cell-based therapies.	28600830
Virus Diseases	Stem Cell Exhaustion	Impact of stem cell graft on early viral infections and immune reconstitution after allogeneic transplantation in adults.	28601677
Virus Diseases	Stem Cell Exhaustion	Viral infections are well-known complications after allogeneic stem cell transplant (allo-SCT).	28601677
Migration, Cell	Stem Cell Exhaustion	Furthermore, we found that overexpressing FZD8 promoted, whereas silencing FZD8 suppressed, PCa cell migration, invasion and stem cell-like phenotypes in vitro, through the activation of canonical Wnt/b-catenin signaling.	28602974
Multiple Myeloma	Stem Cell Exhaustion	Although outpatient autologous stem cell transplantation (ASCT) is safe and feasible in most instances, some patients undergoing planned outpatient transplantation for multiple myeloma (MM) will need inpatient admission for transplantation-related complications.	28603071
Malignant tumor of colon	Stem Cell Exhaustion	The characterization of colon cancer stem cells (CSCs) may help to develop novel diagnostic and therapeutic procedures.	28604612
Specialty Type - cancer	Stem Cell Exhaustion	Emerging evidence has emphasized the importance of cancer therapies targeting an abnormal metabolic state of tumor-initiating cells (TICs) in which they retain stem cell-like phenotypes and nicotinamide adenine dinucleotide (NAD+) metabolism.	28604662
Hematologic Neoplasms	Stem Cell Exhaustion	Eighty-one patients with high-risk hematological malignancies received unmanipulated haploidentical stem cell transplants (haploSCT) using the same protocol at four Spanish institutions.	28604667
Negative Regulation of Cell Cycle, Specialty Type - cancer	Stem Cell Exhaustion	Knockdown of SOX9 induced apoptosis, cell-cycle arrest, as well as decreased expression of cancer stem cell markers were determined by Western blot and flow cytometric assays.	28606919
FBXO8 gene, diabetic	Stem Cell Exhaustion	Compared to data from FBS and normal serum, diabetic serum reduced the stem cell survival and chemotaxis toward VEGF and SDF-1a (P < 0.05).	28608561
Diabetes Mellitus	Stem Cell Exhaustion	Angiogenic and Restorative Abilities of Human Mesenchymal Stem Cells Were Reduced Following Treatment With Serum From Diabetes Mellitus Type 2 Patients.	28608561
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	This experiment investigated the impact of serum from patients with type 2 diabetes mellitus on the angiogenic behavior of human mesenchymal stem cells in vitro.	28608561
diabetic	Stem Cell Exhaustion	Paracrine restorative effect of diabetic stem cells was tested on pancreatic b cells.	28608561
diabetic	Stem Cell Exhaustion	The paracrine angiogenic potential of diabetic stem cells was disturbed via the changes in the dynamic of Ang-1, Ang-2, and VEGF.	28608561
Diabetes	Stem Cell Exhaustion	Surface plasmon resonance analysis showed that diabetes could induce an aberrant increase in the interaction of stem cells with endothelial cells.	28608561
diabetic	Stem Cell Exhaustion	Conditioned media prepared from diabetic stem cells were unable to decrease fatty acid accumulation in b-cells (P < 0.05).	28608561
diabetic	Stem Cell Exhaustion	The level of insulin secreted by b-cells was not affected after exposure to supernatant from diabetic or non-diabetic mesenchymal stem cells.	28608561
Diabetes	Stem Cell Exhaustion	Data suggest diabetes could decrease angiogenic and restorative effect of stem cells in vitro.	28608561
Osteoporotic Fractures	Stem Cell Exhaustion	The present study was designed to evaluate the in vivo effects of zoledronic acid (ZA) on the proliferation and osteoblastic commitment of mesenchymal stem cells (MSC) in osteoporotic patients.	28608802
Hypoxia	Stem Cell Exhaustion	Enhanced chondrogenesis of bone marrow-derived stem cells by using a combinatory cell therapy strategy with BMP-2/TGF-b1, hypoxia, and COL1A1/HtrA1 siRNAs.	28611369
Keratopathy	Stem Cell Exhaustion	A 41-year-old man with a history of aniridic keratopathy and limbal stem cell deficiency underwent KLAL in his right eye.	28614157
Lymphoma, Non-Hodgkin, Familial, Aggressive Adult Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Patients with relapsed aggressive non-Hodgkin lymphoma (NHL) are often treated with platinum-based chemoimmunotherapy regimens in preparation for autologous stem cell transplant.	28614905
MS gene, White matter atrophy	Stem Cell Exhaustion	Impact of immunoablation and autologous hematopoietic stem cell transplantation on gray and white matter atrophy in multiple sclerosis.	28617152
Atrophic, MS gene	Stem Cell Exhaustion	Immunoablation and autologous hematopoietic stem cell transplantation (IA/aHSCT) halts relapses, white matter (WM) lesion formation, and pathological whole-brain (WB) atrophy in multiple sclerosis (MS) patients.	28617152
Histiocytosis, Non-Langerhans-Cell, Lymphoproliferative Disorders	Stem Cell Exhaustion	Non-Langerhans histiocytosis is a group of inflammatory lymphoproliferative disorders originating from non-clonal expansion of hematopoietic stem cells into cytokine-secreting dendritic cells or macrophages.	28617889
Specialty Type - cancer, Tumor necrosis	Stem Cell Exhaustion	Serum levels of several biomarkers were significantly (p <= 0.001) higher in cancer patients than in healthy controls, particularly alpha-fetoprotein, cancer antigen 15-3, cancer antigen 19-9, migration inhibitory factor, carcinoembryonic antigen, cancer antigen 125, hepatocyte growth factor, soluble Fas, tumor necrosis factor-a, stem cell factor, and osteopontin.	28618926
Hypertension, CTCAE	Stem Cell Exhaustion	Since HDL mediates important protective actions on the vascular endothelium by increasing the number of circulating endothelial progenitor cells (CD34-positive cells), the level of circulating CD34-positive cells should influence the association between HDL and hypertension.	28619079
Multiple Myeloma	Stem Cell Exhaustion	The importance of the number of transplanted cells with dipeptidyl peptidase-4 expression on the haematopoietic recovery and lymphocyte reconstitution in patients with multiple myeloma after autologous haematopoietic stem-cell transplantation.	28620928
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Autologous haematopoietic stem cell transplantation (AHSCT) remains recommended treatment in the first remission in multiple myeloma (MM).	28620928
Impaired T cell function	Stem Cell Exhaustion	We report that subretinal transplantation of RPE stem cell (RPESC)-derived RPE cells (RPESC-RPE) preserved vision in a rat model of RPE cell dysfunction.	28625537
Neoplasms	Stem Cell Exhaustion	The levels of miR16 and its targeted genes in tumor tissue of GBM and GBM SGH44, U87, U251 cells as well as their stem cell counterparts were measured by qRT-PCR or western blot or immunohistochemistry.	28628119
Adult Glioblastoma, Secondary Neoplasm	Stem Cell Exhaustion	Differential expression of miR16 in glioblastoma and glioblastoma stem cells: their correlation with proliferation, differentiation, metastasis and prognosis.	28628119
Glioblastoma	Stem Cell Exhaustion	The function of miR16 in multiforme glioblastoma multiforme (GBM) and its stem cells (GSCs) remains elusive.	28628119
Toxic effect, PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Missing HLA C group 1 ligand in patients with AML and MDS is associated with reduced risk of relapse and better survival after allogeneic stem cell transplantation with fludarabine and treosulfan reduced toxicity conditioning.	28631269
Specialty Type - cancer, Squamous cell carcinoma	Stem Cell Exhaustion	Cancer stem cell markers in patterning differentiation and in prognosis of oral squamous cell carcinoma.	28631562
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	This study aims to correlate cancer stem cell markers (CD44 and CD147) with tumor differentiation and evaluate their subsequent effect on prognosis.	28631562
Lip and Oral Cavity Carcinoma, Specialty Type - cancer, Squamous cell carcinoma	Stem Cell Exhaustion	Subsequently, relevance of these cancer stem cell markers in patterning the differentiation characteristics was evaluated in oral squamous cell carcinoma cell lines originating from different grades of oral cancer.	28631562
Specialty Type - cancer, Squamous cell carcinoma	Stem Cell Exhaustion	Expression profiling indicated higher expression of cancer stem cell and epithelial-mesenchymal transition markers in SCC029B (poorly differentiated squamous cell carcinoma originated; p <= 0.001), which was further translated into increased spheroid formation, migration, and invasion (p < 0.001) as compared to cell line of well-differentiated squamous cell carcinoma origin.	28631562
Aggressive behavior, Specialty Type - cancer	Stem Cell Exhaustion	Differentiation is a major histological parameter determining tumor aggressiveness and prognosis of the patient; cancer stem cells with their slow dividing and undifferentiated nature might be one of the factors determining the same.	28631562
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	He was known to have non-Hodgkin's lymphoma under remission following treatment with chemotherapy and stem cell transplantation, twice.	28632962
Primary central nervous system lymphoma	Stem Cell Exhaustion	R-MTX-ARA-C followed by autologous stem cell transplantation seems a promising strategy with high response rates in PCNSL.	28633037
Alzheimers Disease	Stem Cell Exhaustion	Sortilin-Related Receptor Expression in Human Neural Stem Cells Derived from Alzheimer's Disease Patients Carrying the APOE Epsilon 4 Allele.	28634550
Up	Stem Cell Exhaustion	Here, we analyzed SORL1 expression in neural stem cells (NSCs) from AD patients carrying null, one, or two copies of the APOE4 allele.	28634550
Retinal ischemia	Stem Cell Exhaustion	Protective Effect of Intravitreal Administration of Exosomes Derived from Mesenchymal Stem Cells on Retinal Ischemia.	28636406
Hodgkin Disease	Stem Cell Exhaustion	Cost-effectiveness analysis of consolidation with brentuximab vedotin for high-risk Hodgkin lymphoma after autologous stem cell transplantation.	28640385
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	In a recent randomized, placebo-controlled trial, consolidation treatment with brentuximab vedotin (BV) decreased the risk of Hodgkin lymphoma (HL) progression after autologous stem cell transplantation (ASCT).	28640385
Kidney Failure, Chronic, corticotropin-releasing factor, human	Stem Cell Exhaustion	The pathogenic events responsible for the reduction of endothelial progenitor cell (EPC) number and function seen in patients with chronic renal failure (CRF) are poorly understood.	28641152
Adult Glioblastoma, Glioblastoma	Stem Cell Exhaustion	Glioblastomas have a poor prognosis, possibly because of a subpopulation of therapy-resistant stem cells within the heterogeneous glioblastoma.	28642175
Adult Glioblastoma	Stem Cell Exhaustion	Because the subventricular zone is the main source of neural stem cells, we aimed at characterizing the subventricular zone using diffusion tensor imaging (DTI) to show subventricular zone involvement in glioblastoma.	28642175
Specialty Type - cancer	Stem Cell Exhaustion	A small subset of cells, cancer stem cells (CSCs), with self-renewal properties have become a major focus of current cancer research.	28645102
Hollings Cancer Center	Stem Cell Exhaustion	The eight disease groups we identified were: 1) CK19(-) HCC, 2) CK19(-) scirrhous HCC, 3) CK19(+) HCC, 4) stem cell feature of cHC-CCA, 5) classical cHC-CCA, 6) cholangiolocellular IHCCA, 7) non-cholangiolocellular IHCCA, and 8) EHBCA.	28645247
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Comparison of matched sibling donors versus unrelated donors in allogeneic stem cell transplantation for primary refractory acute myeloid leukemia: a study on behalf of the Acute Leukemia Working Party of the EBMT.	28646908
Disease remission	Stem Cell Exhaustion	Allogeneic stem cell transplantation (HSCT) in active disease is an alternative therapeutic strategy.	28646908
Specialty Type - cancer	Stem Cell Exhaustion	The effect of HOXB7 on expression of cancer stem cell markers was evaluated.	28646927
Specialty Type - cancer	Stem Cell Exhaustion	Moreover, the cancer stem cell markers EPCAM and NANOG were up-regulated by HOXB7.	28646927
Healthcare Encounters Domain, Trauma	Stem Cell Exhaustion	HO is most commonly diagnosed in the setting of localized trauma, which results in improper differentiation of progenitor cells, leading to aberrant tissue formation.	28647521
Degenerative disorder of cartilage	Stem Cell Exhaustion	To clarify whether the peptide can inhibit cartilage degeneration without stimulating bone formation, we first performed a proliferation assay using C3H10T1/2 (the murine mesenchymal stem cell line), which is the common origin of both chondrocytes and osteoblasts.	28648299
Specialty Type - cancer	Stem Cell Exhaustion	Sam68 Allows Selective Targeting of Human Cancer Stem Cells.	28648376
Specialty Type - cancer	Stem Cell Exhaustion	Targeting of human cancer stem cells (CSCs) requires the identification of vulnerabilities unique to CSCs versus healthy resident stem cells (SCs).	28648376
Immune System Diseases	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) possess immunosuppressive effects, and are widely used for regenerative medicine and immune disorders.	28648928
Thrombomodulin Alfa	Stem Cell Exhaustion	TMA was retrospectively assessed in 771 patients after allogeneic stem cell transplantation (alloSCT).	28650448
Specialty Type - cancer, Malignant Meningioma	Stem Cell Exhaustion	It has been proposed that high recurrence rates of malignant meningiomas are linked to cancer stem cells.	28651379
Graft-vs-Host Disease, Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	BACKGROUND We identified risk factors for acute and chronic graft-versus-host disease (aGVHD and cGVHD, respectively) in recipients after hematopoietic stem cell transplantation (HSCT) from unrelated donors in the China Marrow Donor Program (CMDP).	28652564
Acute GVH disease	Stem Cell Exhaustion	This HLA-DPB1 GVL effect without induction of severe acute GVHD or deterioration of survival rate has not been reported in unrelated bone marrow or peripheral blood stem cell transplantations, suggesting apparent advantages of UR-CBT.	28652579
Multiple Myeloma	Stem Cell Exhaustion	Comparison of biosimilar filgrastim, originator filgrastim, and lenograstim for autologous stem cell mobilization in patients with multiple myeloma.	28653421
Somatic, Fresh Water	Stem Cell Exhaustion	Accumulating evidence indicates that a small RNA-based gene regulatory machinery, the Piwi-piRNA pathway, represents a shared feature of nonaging (potentially immortal) biological systems, including the germline, somatic cancer stem cells, and certain 'lower' eukaryotic organisms like the planarian flatworm and freshwater hydra.	28653810
Stomatitis	Stem Cell Exhaustion	Impressive tissue regeneration of severe oral mucositis post stem cell transplantation using cord blood platelet gel.	28656652
Cytomegalovirus Infections, Esophageal Mucositis, Neutropenia, Bacterial sepsis, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	A patient with non-Hodgkin lymphoma who was undergoing autologous hematopoietic stem cell transplantation developed severe oral and esophageal mucositis with severe bacterial sepsis and cytomegalovirus infection, causing prolonged neutropenia.	28656652
Pancreatic Ductal Adenocarcinoma, Specialty Type - cancer, Pancreatitis	Stem Cell Exhaustion	Expression and Clinical Significance of Cancer Stem Cell Markers CD24, CD44, and CD133 in Pancreatic Ductal Adenocarcinoma and Chronic Pancreatitis.	28659655
Specialty Type - cancer, Carcinogenesis	Stem Cell Exhaustion	Cancer stem cells (CSC) play an important role in pancreatic carcinogenesis and prognosis.	28659655
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Long-Term Outcome of Autologous Hematopoietic Stem Cell Transplantation (AHSCT) for Acute Myeloid Leukemia (AML)- Single Center Retrospective Analysis.	28660547
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	For patients with acute myeloid leukemia (AML) in complete remission without an acceptable HLA donor, the autologous hematopoietic stem cell transplantation (AHSCT) may remain a therapeutic option as remission consolidation, however its role is still a subject of continued debate.	28660547
Lymphoproliferative Disorders	Stem Cell Exhaustion	Prior to transplantation of hematopoietic stem cells or solid organ, donor and recipient EBV serostatus has to be determined to assess risks of post-transplant lymphoproliferative disorders.	28661055
Toxoplasmosis, Cerebral	Stem Cell Exhaustion	Cerebral toxoplasmosis after haematopoietic stem cell transplantation.	28664700
Communicable Diseases	Stem Cell Exhaustion	The infection is severe and difficult to diagnose in patients receiving allogeneic haematopoietic stem cell transplantation (HSCT).	28664700
Toxoplasmosis, Cerebral, Fanconi Anemia	Stem Cell Exhaustion	The case is presented of cerebral toxoplasmosis in a 17-year-old youth with Fanconi anaemia treated with haematopoietic stem cell transplantation (HSCT).	28664700
Serous Cystadenocarcinoma, Carcinoma in situ of fallopian tube	Stem Cell Exhaustion	As many epithelial transitional regions contain stem cells, we also determined the expression of stem cell markers in the normal fallopian tube, tubal intraepithelial lesions and high-grade serous carcinomas.	28664938
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Spliced variant isoforms of CD44 (CD44v) are a marker of cancer stem cells in solid tumors.	28667792
Cessation of life, Specialty Type - cancer	Stem Cell Exhaustion	The serum concentration of free CD44v protein was increased after the first cycle of treatment, possibly reflecting death of cancer stem cells.	28667792
diabetic	Stem Cell Exhaustion	Impact of statin therapy intensity on endothelial progenitor cells after percutaneous coronary intervention in diabetic patients.	28668399
diabetic	Stem Cell Exhaustion	A low number (that is, <=0.0038 per 100 peripheral mononuclear cells) of circulating endothelial progenitor cells (EPC) is common in diabetic patients.	28668399
Mycoses	Stem Cell Exhaustion	Epidemiology and Risk Factors for Invasive Fungal Diseases among Allogeneic Hematopoietic Stem Cell Transplant Recipients in Korea: Results of "RISK" Study.	28668492
Mycoses	Stem Cell Exhaustion	Incidence, epidemiology, and risk factors of invasive fungal diseases (IFDs) in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients can vary from different cohorts and countries.	28668492
Multiple Myeloma	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation (ASCT) is an established treatment for multiple myeloma (MM), yet the impact of transplanted CD34+ cell dose remains unresolved, especially in patients over the age of 65 years.	28669690
Graft-vs-Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Knowing the impact of chronic graft-versus-host disease (GVHD) on quality of life (QoL) after allogeneic hematopoietic stem cell transplantation (allo-HCT) by GVHD type and severity is critical for providing care to transplant survivors.	28669922
Comorbidity	Stem Cell Exhaustion	Hematopoietic Cell Transplantation-Specific Comorbidity Index Predicts Morbidity and Mortality in Autologous Stem Cell Transplantation.	28669923
Haiti	Stem Cell Exhaustion	Further investigations are necessary to establish whether this stem cell-based therapy approach in HT could avoid lifetime hormone replacement therapy by inducing T-cell education.	28673339
Hashimoto Disease	Stem Cell Exhaustion	Human limbal fibroblast-like stem cells induce immune-tolerance in autoreactive T lymphocytes from female patients with Hashimoto's thyroiditis.	28673339
Nephroblastoma, Myeloid neoplasm	Stem Cell Exhaustion	Clinical Utility of Wilms' Tumor 1 Monitoring in Patients with Myeloid Malignancy and Prior Allogeneic Hematopoietic Stem Cell Transplantation.	28673850
Myeloid neoplasm	Stem Cell Exhaustion	Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) is 1 of the standard treatments for myeloid malignancy, relapse remains a major obstacle to cure.	28673850
Leukemia, Myelocytic, Acute, Deficit	Stem Cell Exhaustion	Evidence for a pre-existing telomere deficit in non-clonal hematopoietic stem cells in patients with acute myeloid leukemia.	28674830
Multiple Myeloma	Stem Cell Exhaustion	Here, we present the results of an open-label single-arm pilot study in patients with multiple myeloma undergoing autologous stem cell transplantation (ASCT) to assess the safety and efficacy of desipramine combined with G-SCF to induce HSC mobilization.	28675459
Multiple Myeloma	Stem Cell Exhaustion	Stimulation of adrenergic activity by desipramine enhances hematopoietic stem and progenitor cell mobilization along with G-CSF in multiple myeloma: A pilot study.	28675459
Hematopoietic, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The successful immunotherapy of acute myeloid leukemia (AML) has been hampered because most potential antigenic targets are shared with normal hematopoietic stem cells (HSCs), increasing the risk of sustained and severe hematopoietic toxicity following treatment.	28676343
Charcot-Marie-Tooth Disease, Charcot-Marie-Tooth disease, X-linked, 1	Stem Cell Exhaustion	Generation of induced pluripotent stem cell (iPSC) line from a 36-year-old Charcot-Marie-Tooth disease patient with GJB1 mutation (CMTX).	28677541
Charcot-Marie-Tooth disease, X-linked, 1	Stem Cell Exhaustion	We generated induced pluripotent stem cell (iPSC) line from 36-year-old CMTX disease patient by electroporation of skin fibroblasts with episomal vectors encoding OCT4, SOX2, KLF4, L-MYC, LIN28 and shRNA-p53.	28677541
Multiple Myeloma	Stem Cell Exhaustion	Telomere length is positively associated with the expression of IL-6 and MIP-1a in bone marrow mesenchymal stem cells of multiple myeloma.	28677723
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Potential roles of mesenchymal stem cells (MSCs) in the pathogenesis of multiple myeloma (MM) are largely unknown.	28677723
Specialty Type - cancer, Adenocarcinoma of large intestine	Stem Cell Exhaustion	Expression of epithelial-mesenchymal transition and cancer stem cell markers in colorectal adenocarcinoma: Clinicopathological significance.	28677737
Specialty Type - cancer, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Cancer stem cells (CSCs) display stemness features and might be implicated in tumor initiation, local recurrence and metastasis.	28677737
Hematologic Neoplasms	Stem Cell Exhaustion	To evaluate the cost-effectiveness of a lifestyle modification program targeting long-term survivors of hematological malignancy treated with hemopoietic stem cell transplantation, a multistate life table Markov model was used to calculate health outcomes for both the intervention and no intervention.	28678411
Chronic Lymphocytic Leukemia, Virus Diseases, Squamous cell carcinoma	Stem Cell Exhaustion	Prevalence of cutaneous viral infections in incident cutaneous squamous cell carcinoma detected among chronic lymphocytic leukemia and hematopoietic stem cell transplant patients.	28679298
Graft-vs-Host Disease, Cessation of life	Stem Cell Exhaustion	Graft-versus-host disease (GvHD)-free, relapse-free survival (GRFS) is a recently reported composite endpoint that allows to simultaneously estimate risk of death, relapse and GvHD after allogeneic hematopoietic stem cell transplantation (HSCT).	28679328
altretamine/cisplatin/cyclophosphamide protocol	Stem Cell Exhaustion	Analysis of differential expression of miR-223 in platelets of elderly CHD patients before and after the autologous stem cell transplantation.	28682424
Coronary heart disease, altretamine/cisplatin/cyclophosphamide protocol	Stem Cell Exhaustion	The aim of this study was to investigate the differential expression of miR-223 in the platelets of elderly patients with coronary heart disease (CHD) before and after autologous stem cell transplantation.	28682424
altretamine/cisplatin/cyclophosphamide protocol	Stem Cell Exhaustion	Compared to the levels before the treatment, the results of flow cytometry revealed that the phosphorylation levels of VASP in platelet of CHD patients who received the autologous stem cell transplantation was significantly increased (p<0.05).	28682424
altretamine/cisplatin/cyclophosphamide protocol	Stem Cell Exhaustion	The results of qRT-PCR showed that the expressions of Ago-2 and miR-223 in elderly CHD patients were significantly increased after autologous stem cell transplantation compared to those before the treatment with statistically significant differences (p<0.05).	28682424
altretamine/cisplatin/cyclophosphamide protocol	Stem Cell Exhaustion	Therefore, the miR-223 expression of platelets was significantly decreased after elderly CHD patients received autologous stem cell transplantation.	28682424
Anemia, Sickle Cell, GDC Comorbidity Terminology, Anemia, Ulcer	Stem Cell Exhaustion	Sickle Cell Anemia and Comorbid Leg Ulcer Treated With Curative Peripheral Blood Stem Cell Transplantation.	28682672
Anemia, Sickle Cell, Renal carnitine transport defect	Stem Cell Exhaustion	Allogeneic bone marrow transplantation or peripheral blood stem cell transplantation (PBSCT) are the only curative therapies for patients with sickle cell disease (SCD).	28682672
Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) has a well-established role in the treatment of patients with multiple myeloma.	28684379
Liver carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	The effects of the location of cancer stem cell marker CD133 on the prognosis of hepatocellular carcinoma patients.	28687090
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	CD133 (prominin-1) is widely believed to be a cancer stem cell marker in various solid tumor types, and CD133 has been correlated with tumor-initiating capacity.	28687090
Papillary thyroid carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Prognostic value of putative cancer stem cell markers (CD24, CD44, CD133, and ALDH1) in human papillary thyroid carcinoma.	28687160
Specialty Type - cancer	Stem Cell Exhaustion	We hypothesized that cancer stem cells (CSCs) are responsible for the poor outcome and aggressive clinicopathological factors.	28687160
Acute GVH disease	Stem Cell Exhaustion	Associations between acute GVHD-related biomarkers and endothelial cell activation after allogeneic hematopoietic stem cell transplantation.	28687251
Graft-vs-Host Disease	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) can cause serious transplant-related complications such as graft-versus-host disease (GVHD).	28687251
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	We show that the expression levels of SOX5, SOX6, and SOX21 (SOX5/6/21) transcription factors increase in stem cells of the subventricular zone (SVZ) upon oncogenic stress, whereas their expression in human glioma decreases during malignant progression.	28687615
Neoplasms	Stem Cell Exhaustion	Altogether, these results provide evidence that SOX5/6/21 play a central role in driving a tumor suppressor response in brain stem cells upon oncogenic insult.	28687615
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Haploidentical Hematopoietic Cell Transplant with Post-Transplant Cyclophosphamide and Peripheral Blood Stem Cell Grafts in Older Adults with Acute Myeloid Leukemia or Myelodysplastic Syndrome.	28688919
Kidney Failure, Chronic	Stem Cell Exhaustion	Ninety-six percent received bortezomib and 44% stem cell transplantation as well as bortezomib, 68% achieved complete or very good partial hematologic response (CR/VGPR), 34% had ESRD, and 39% RR.	28689003
Cytomegalovirus Infections	Stem Cell Exhaustion	We previously showed that GSH levels in plasma, as measured by untargeted 1H nuclear magnetic resonance, are higher in allogeneic stem cell transplant (allo-SCT) recipients who subsequently develop CMV viraemia.	28691896
Eye Injuries	Stem Cell Exhaustion	Is there a role for stem cells in treating articular injury?	28692374
Cartilage injury	Stem Cell Exhaustion	Stem cells may hold the answer to the age-old problem of articular cartilage injury but more robust evidence is required.	28692374
Have Been Vomiting, Refractory Chemotherapy-Induced Nausea and Vomiting	Stem Cell Exhaustion	Olanzapine Reduces Chemotherapy-induced Nausea and Vomiting Compared With Aprepitant in Myeloma Patients Receiving High-dose Melphalan Before Stem Cell Transplantation: A Retrospective Study.	28694084
Chemotherapy-induced nausea and vomiting, Chemotherapy-induced Nausea and Vomiting Questionnaire	Stem Cell Exhaustion	Acute and delayed chemotherapy-induced nausea and vomiting (CINV) occurs in most patients who receive high-dose melphalan and significantly affects patients' quality of life during autologous stem cell transplantation.	28694084
Chemotherapy-induced Nausea and Vomiting Questionnaire	Stem Cell Exhaustion	A retrospective study was conducted to compare the effectiveness of olanzapine- versus aprepitant-based regimens for CINV prevention in adult hematopoietic stem cell recipients who received high-dose melphalan.	28694084
leukemia	Stem Cell Exhaustion	Allogeneic Hematopoietic Stem Cell Transplantation with Myeloablative Conditioning Is Associated with Favorable Outcomes in Mixed Phenotype Acute Leukemia.	28694182
Up	Stem Cell Exhaustion	The TRPC6 reduction in AD patients was further confirmed in blood RNA samples from The Australian Imaging, Biomarkers and Lifestyle Flagship Study of Aging, in post-mortem brain tissues from The Netherlands Brain Bank and in induced pluripotent stem cells-derived neurons from Chinese donors.	28696436
Fracture, Nonunion of Bone	Stem Cell Exhaustion	Atrophic and oligotrophic nonunions have poor biology at the fracture site to promote bone growth and would therefore benefit from autogenous iliac bone graft, as this technique is osteoinductive, osteoconductive, and osteogenic stem cells.	28697075
Adult T-Cell Lymphoma/Leukemia, Hypoxia	Stem Cell Exhaustion	Analyses of global gene expression profiles of ASXL1-mutated versus wild-type human leukemia cells as well as heterozygote versus wild-type mouse marrow precursor cells, with or without MN1 overexpression, highlighted the association of in vivo Asxl1 mutation to the expression of hypoxia, multipotent progenitors, hematopoietic stem cells, KRAS, and MEK gene sets.	28697759
Ischemia	Stem Cell Exhaustion	Improvement in asymmetric dimethylarginine and oxidative stress in patients with limb salvage after autologous mononuclear stem cell application for critical limb ischemia.	28697789
Malignant neoplasm of breast, Childhood Breast Carcinoma, Triple Negative Breast Neoplasms	Stem Cell Exhaustion	Here we immunohistochemically studied expression patterns of CLDNs in 222 primary invasive breast cancers including 68 triple-negative breast cancers (TNBCs), and examined their correlation with epithelial-to-mesenchymal transition (EMT)-related markers, breast cancer stem cell (BCSC) markers, and clinicopathological features including patients' clinical outcome.	28699235
Tissue damage, Amyloidosis	Stem Cell Exhaustion	Elevation of serum lactate dehydrogenase in AL amyloidosis reflects tissue damage and is an adverse prognostic marker in patients not eligible for stem cell transplantation.	28699650
Cessation of life	Stem Cell Exhaustion	Elevated LDH was an independent prognostic marker for overall survival and for death within 6 months of diagnosis, but this was restricted to patients not eligible for stem cell transplant.	28699650
Specialty Type - cancer	Stem Cell Exhaustion	Only ZEB1 was significantly associated with cancer stem cell (CSC) markers.	28700115
Malignant melanoma of conjunctiva	Stem Cell Exhaustion	A 69-year-old with conjunctival melanoma on her left eye developed total limbal stem cell deficiency (LSCD) after multiple cycles of topical mitomycin.	28700252
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Dysregulation of a novel miR-23b/27b-p53 axis impairs muscle stem cell differentiation of humans with type 2 diabetes.	28702332
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	In the current study, we describe an impaired myogenic capacity of muscle stem cells isolated from humans with type 2 diabetes (T2DM) and assess whether this phenotype is regulated by miRNAs.	28702332
Viremia	Stem Cell Exhaustion	Dynamics of Torque Teno virus viremia could predict risk of complications after allogeneic hematopoietic stem cell transplantation.	28702856
Hematological Disease	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an established treatment option for several hematological diseases.	28702856
Hemolysis (biological function)	Stem Cell Exhaustion	Transient hemolysis due to anti-D and anti-A1 produced by engrafted donor's lymphocytes after allogeneic unmanipulated haploidentical hematopoietic stem cell transplantation.	28703860
Immune-mediated	Stem Cell Exhaustion	Although rabbit anti-T-lymphocyte globulin (ATLG) is largely used for the prevention of immune-mediated complications in patients given allogeneic haemopoietic stem-cell transplantation (HSCT) from an unrelated donor, the optimum dose of this drug in children is still undefined.	28705454
Neoplasms	Stem Cell Exhaustion	b-catenin is a cell-cell adhesion protein, whose nuclear localization has been linked to the pathogenesis of adaCP: its nuclear accumulation is associated to the presence of a tumor stem cell subpopulation.	28709442
Craniopharyngioma	Stem Cell Exhaustion	In this study, we measured the immunohistochemical expression of b-catenin, stem cell markers (CD133, CD166), Ki67 and pATMin 45 craniopharyngiomas and correlated it with clinicopathologic features.	28709442
Specialty Type - cancer	Stem Cell Exhaustion	This fact, and the uncovering of the genetic basis of plasticity in somatic cells and cancer stem cells, open a door to a world where maintenance and regeneration of organ systems maintain health and extend life expectancy beyond its present limits.	28710142
Failure, leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Leukemia stem cells (LSCs) are considered to be the cause of treatment failure and relapse in acute myeloid leukemia (AML).	28710745
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	As LSCs and hematopoietic stem cells (HSCs) are enriched in CD34+CD38- populations, CD34+CD38- cells from KG1a and Kasumi-1 cell lines as well as CD34+ blasts from AML patients were used as LSC models, while CD34+ cells from healthy donors were used as normal hematopoietic cells.	28710745
Myeloid neoplasm	Stem Cell Exhaustion	A Chemotherapy-Only Regimen of Busulfan, Melphalan, and Fludarabine, and Rabbit Antithymocyte Globulin Followed by Allogeneic T-Cell Depleted Hematopoietic Stem Cell Transplantations for the Treatment of Myeloid Malignancies.	28711727
Graft-vs-Host Disease, Toxic effect	Stem Cell Exhaustion	We sought to develop a myeloablative chemotherapeutic regimen to secure consistent engraftment of T-cell depleted (TCD) hematopoietic stem cell transplantations (HSCT) without the need for total body irradiation, thereby reducing toxicity while maintaining low rates of graft-versus-host disease (GVHD) and without increasing relapse.	28711727
Bone graft - material	Stem Cell Exhaustion	TCD was accomplished by CD34+-selection followed by E-rosette depletion for peripheral blood stem cell grafts and, for bone marrow grafts, by soybean agglutination followed by E-rosette depletion.	28711727
Relapsing course	Stem Cell Exhaustion	Phase II Study of Sequential Infusion of Donor Lymphocyte Infusion and Cytokine-Induced Killer Cells for Patients Relapsed after Allogeneic Hematopoietic Stem Cell Transplantation.	28712935
Stable chronic Graft vs Host Disease	Stem Cell Exhaustion	By multivariate analysis, the type of relapse, the presence of cGVHD, and a short (<6 months) time from allogeneic hematopoietic stem cell transplantation to relapse were the significant predictors of survival.	28712935
End Stage Liver Disease	Stem Cell Exhaustion	Effects of age on biological and functional characterization of adipose-derived stem cells from patients with end-stage liver disease.	28713938
Encephalitis	Stem Cell Exhaustion	Dengue encephalitis in allogenic hematopoietic stem cell transplantation recipient.	28714943
Childhood Breast Carcinoma	Stem Cell Exhaustion	Expression profiling revealed 780 genes for which the expression level was affected by the loss of DIP2C, including the tumour-suppressor encoding CDKN2A gene, the epithelial-mesenchymal transition (EMT) regulator-encoding ZEB1, and CD44 and CD24 that encode breast cancer stem cell markers.	28716088
Wiskott-Aldrich Syndrome, WAS protein, human	Stem Cell Exhaustion	Until recently, hematopoietic stem cell transplantation was the only curative option for Wiskott-Aldrich syndrome (WAS).	28716862
Hemoglobinuria, Non-Malignant	Stem Cell Exhaustion	Paroxysmal nocturnal haemoglobinuria is a non-malignant stem cell disorder due to acquired somatic mutations in cell surface anchored proteins CD55 and CD59.	28718265
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Expression of embryonic stem cell markers in acute myeloid leukemia.	28718379
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The aim of our study was to evaluate the expression of embryonic antigens (OCT4, NANOG, SOX2, SSEA1, SSEA3) in hematopoietic stem cell subsets (CD34+CD38- and CD34+CD38+) from normal bone marrows and in samples from acute myeloid leukemia patients.	28718379
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukemia is driven by leukemic stem cells which can be identified by cross lineage expression or arrest of differentiation compared to normal hematopoietic stem cells.	28718379
Sample Size Calculation	Stem Cell Exhaustion	Given the difficulty in treating SSc, we conducted this study to investigate the effect of combined plasmapheresis (PE) and allogeneic mesenchymal stem cells transplantation (MSCT) therapy on SSc.	28724445
Hematologic Neoplasms	Stem Cell Exhaustion	Decrease in Vancomycin-Resistant Enterococcus Colonization After Extensive Renovation of a Unit Dedicated to the Treatment of Hematologic Malignancies and Hematopoietic Stem-Cell Transplantation.	28724453
Hemopoietic stem cell transplant	Stem Cell Exhaustion	SETTING A regional referral center for acute leukemia and hematopoietic stem-cell transplantation.	28724453
Acute leukemia	Stem Cell Exhaustion	PATIENTS Overall, 536 consecutive hospital admissions for newly diagnosed acute leukemia or a first autologous or allogeneic stem-cell transplantation were reviewed.	28724453
Malignant Neoplasms	Stem Cell Exhaustion	Randomized controlled trial on the effects of a supervised high intensity exercise program in patients with a hematologic malignancy treated with autologous stem cell transplantation: Results from the EXIST study.	28727771
Fatigue, Multiple Myeloma	Stem Cell Exhaustion	This single blind, multicenter randomized controlled trial aimed to evaluate the effectiveness of a supervised high intensity exercise program on physical fitness and fatigue in patients with multiple myeloma or lymphoma recently treated with autologous stem cell transplantation.	28727771
B-Cell Lymphomas, Myeloma cell	Stem Cell Exhaustion	Quantification of marrow hematogones following autologous stem cell transplant in adult patients with plasma cell myeloma or diffuse large B-cell lymphoma and correlation with outcome.	28728454
Myeloma cell	Stem Cell Exhaustion	In this retrospective study, we quantified the hematogone (normal B-lineage precursor) population by flow cytometric immunophenotyping in post-transplant bone marrow biopsy specimens from adult patients who received an autologous stem cell transplant for either plasma cell myeloma (n = 57) or diffuse large B-cell lymphoma (n = 73).	28728454
Diabetes	Stem Cell Exhaustion	Psychosocial Response to New-Onset Diabetes as a Long-Term Effect of Allogeneic Hematopoietic Stem Cell Transplantation.	28728478
Allogeneic Hematopoietic Stem Cell Transplantation, Diabetes, Hematologic Neoplasms	Stem Cell Exhaustion	Currently, little information is available to guide health care practitioners on how to facilitate positive outcomes in individuals who develop new-onset diabetes after allogeneic hematopoietic stem cell transplantation (allo HSCT) for treatment of hematological cancers.	28728478
Glaucoma, CTCAE	Stem Cell Exhaustion	Given its inherent population of stem cells, our hypothesis was that this highly replicative, biological tissue would provide an adequate means of glaucoma tube coverage.	28731936
HIV Infections	Stem Cell Exhaustion	However, CCR5-tropic HIV infection is limited to more differentiated progenitor cells with life spans that are less well understood.	28732051
Mantle cell lymphoma	Stem Cell Exhaustion	Long-Term Results of High-Dose Therapy and Autologous Stem Cell Transplantation for Mantle Cell Lymphoma: Effectiveness of Maintenance Rituximab.	28733266
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	High-dose therapy followed by autologous stem cell transplantation (ASCT) can improve outcomes for mantle cell lymphoma (MCL) but is associated with a high incidence of relapse.	28733266
Hematologic Neoplasms	Stem Cell Exhaustion	T Cell Depletion as an Alternative Approach for Patients 55 Years or Older Undergoing Allogeneic Stem Cell Transplantation as Curative Therapy for Hematologic Malignancies.	28734876
Graft-vs-Host Disease, Hematologic Neoplasms	Stem Cell Exhaustion	T cell-depleted (TCD) allogeneic hematopoietic stem cell transplantation (HSCT) is curative treatment for hematologic malignancies in adults, shown to reduce graft-versus-host disease (GVHD) without increased relapse.	28734876
Malignant Neoplasms	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) has been used as treatment in different hematologic and solid malignancies.	28736021
Multiple Myeloma, Cytopenia	Stem Cell Exhaustion	Outcomes of salvage autologous stem cell transplantation for multiple myeloma with cytopenias and exposure to novel agents.	28737774
Degenerative polyarthritis	Stem Cell Exhaustion	The Stem-Cell Market for the Treatment of Knee Osteoarthritis: A Patient Perspective.	28738432
Degenerative polyarthritis	Stem Cell Exhaustion	The use of stem-cell therapies for the treatment of various musculoskeletal conditions, especially knee osteoarthritis (OA), is rapidly expanding, despite only low-level evidence to support its use.	28738432
Degenerative polyarthritis	Stem Cell Exhaustion	Therefore, the purpose of this study was to determine the current marketed: (1) prices and (2) clinical efficacy of stem-cell therapies for knee OA.	28738432
Degenerative polyarthritis	Stem Cell Exhaustion	Most American stem-cell centers offer therapies for knee OA.	28738432
Degenerative polyarthritis	Stem Cell Exhaustion	These findings offer both patients and physicians insight into the current stem-cell market for knee OA.	28738432
Fever, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We present a case of a 61-year-old Caucasian woman who was hospitalized with fever on day 176 after a matched unrelated stem cell transplant for acute myelogenous leukemia.	28741746
Multiple Myeloma	Stem Cell Exhaustion	Purpose Lenalidomide maintenance therapy after autologous stem-cell transplantation (ASCT) demonstrated prolonged progression-free survival (PFS) versus placebo or observation in several randomized controlled trials (RCTs) of patients with newly diagnosed multiple myeloma (NDMM).	28742454
Cessation of life	Stem Cell Exhaustion	In multivariate analysis, myeloid immunophenotype, prior TKI, age >=58 years, lactate dehydrogenase level >=1227 IU/L, platelet count < 102 K/mL, no history of stem cell transplantation, transition to BP from chronic phase/accelerated phase, and the presence of chromosome 15 aberrations predicted for a significantly increased risk of death.	28743165
Heart Diseases	Stem Cell Exhaustion	Mesenchymal stem cells from sternum: the type of heart disease, ischemic or valvular, does not influence the cell culture establishment and growth kinetics.	28743269
Heart Diseases	Stem Cell Exhaustion	To study the proliferative and differentiation potential of mesenchymal stem cells (MSC), isolated from bone marrow (BM) of sternum, we made a comparative analysis between samples of patients with ischemic (IHD) or non-ischemic valvular (VHD) heart diseases.	28743269
Hematologic Neoplasms, Aspergillosis	Stem Cell Exhaustion	Patients with hematologic malignancies as well as allogeneic hematopoietic stem cell transplantation (HSCT) patients are at high risk for invasive aspergillosis.	28743702
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Acute myeloid leukemia is a hematopoietic stem cell neoplastic disease associated with high morbidity and mortality.	28746590
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The report describes the outcomes of patients with FLT3 internal tandem duplication positive acute myeloid leukemia who relapsed after allogeneic hematopoietic stem cell transplantation and were treated with the combination of re-induction chemotherapy, donor lymphocyte infusion, sorafenib and azacitidine.	28746590
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The combination of induction chemotherapy followed by donor lymphocyte infusion, and the maintenance with azacitidine and sorafenib can be effective approaches in the treatment of post-hematopoietic stem cell transplant and relapsed FLT3 internal tandem duplication positive acute myeloid leukemia patients.	28746590
Degenerative polyarthritis	Stem Cell Exhaustion	Intra-articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A 2-Year Follow-up Study.	28746812
Degenerative polyarthritis, Nasal cartilage loss	Stem Cell Exhaustion	The intra-articular injection of mesenchymal stem cells (MSCs) into the knee has shown a potential for the treatment of generalized cartilage loss in osteoarthritis (OA).	28746812
Malignant Neoplasms	Stem Cell Exhaustion	Hospital mortality of patients initially not admitted was 29.7% and independently associated with malignancy progression[OR: 3.15(1.6-6.19)], allogeneic hematopoietic stem cell transplantation[OR: 2.5(1.06-5.89)], a request based on a clinical respiratory event[OR: 2.36(1.22-4.56)] and severe sepsis[OR: 0.27(0.08-0.99)].	28749989
Premature Menopause	Stem Cell Exhaustion	Many reports have shown that various kinds of stem cells have the ability to recover premature ovarian aging (POA) function.	28750654
Graft-vs-Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Defective post-transplantation thymopoiesis is associated with chronic graft-versus-host disease (GVHD), a multiorgan pathology affecting up to 80% of patients after allogeneic hematopoietic stem cell transplantation (HSCT).	28750779
Neoplasms	Stem Cell Exhaustion	An increased grafting rate for tumours derived from patients with worse outcome (p = 0.006), higher stage (p = 0.038) and higher CD133+/CXCR4+/EpCAM- stem cell content (p = 0.019) was observed whereas a trend towards an association with SUVmax higher than 8 (p = 0.084) was detected.	28751748
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Phase I/II study of the deacetylase inhibitor panobinostat after allogeneic stem cell transplantation in patients with high-risk MDS or AML (PANOBEST trial).	28751769
Degenerative polyarthritis, Usual Severity Pain	Stem Cell Exhaustion	The effect of intra-articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis.	28752679
Degenerative polyarthritis	Stem Cell Exhaustion	This was a prospective, open-label, phase I/II clinical trial to assess the safety and efficacy of a single intra-articular injection of autologous stimulated bone marrow stem cells (BM-SC) in patients with knee OA.	28752679
Amyloidosis	Stem Cell Exhaustion	Comparison of Different Stem Cell Mobilization Regimens in AL Amyloidosis Patients.	28754546
Amyloidosis	Stem Cell Exhaustion	High-dose melphalan (HDM) and autologous blood stem cell transplantation (ABSCT) is an effective treatment for transplantation-eligible patients with systemic light chain (AL) amyloidosis.	28754546
Childhood Breast Carcinoma	Stem Cell Exhaustion	Adipose Progenitor Cell Secretion of GM-CSF and MMP9 Promotes a Stromal and Immunological Microenvironment That Supports Breast Cancer Progression.	28754674
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	Some researchers thought that PROCR+ cells had cancer stem cell ability, which might contribute to progressive behavior in breast cancer.	28756987
Idiopathic pneumonia syndrome	Stem Cell Exhaustion	Idiopathic pneumonia syndrome (IPS) is a complication of allogeneic hematopoietic stem cell transplantation (HSCT) that typically occurs within the first 100 days after transplantation.	28757436
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Higher rates of relapse in maternal recipients of haploidentical hematopoietic stem cell transplantation from adult offspring donors for AML and myelodysplastic syndrome.	28759027
Graft-vs-Host Disease	Stem Cell Exhaustion	The eukaryotic gut virome in hematopoietic stem cell transplantation: new clues in enteric graft-versus-host disease.	28759053
Graft-vs-Host Disease, Inflammatory Bowel Diseases	Stem Cell Exhaustion	Although previously investigated in individuals with inflammatory bowel diseases or solid-organ transplants, virome dynamics in allogeneic hematopoietic stem cell transplantation (HSCT) and enteric graft-versus-host disease (GVHD) remain unexplored.	28759053
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The Dutch-Belgian Cooperative Trial Group for Hematology Oncology Group-65/German-speaking Myeloma Multicenter Group-HD4 (HOVON-65/GMMG-HD4) phase III trial compared bortezomib (BTZ) before and after high-dose melphalan and autologous stem cell transplantation (HDM, PAD arm) compared with classical cytotoxic agents prior and thalidomide after HDM (VAD arm) in multiple myeloma (MM) patients aged 18-65 years.	28761118
Irritable Bowel Syndrome	Stem Cell Exhaustion	This study examined whether the densities of stem- and enteroendocrine cell progenitors are abnormal in the ileum of patients with irritable bowel syndrome (IBS), and whether any abnormalities in ileal enteroendocrine cells are correlated with abnormalities in stem cells and enteroendocrine cell progenitors.	28764761
Periodontal Route of Administration	Stem Cell Exhaustion	Our findings provide evidence that periodontally affected dental tissue (both pulp and gingiva) can be used as a source of MSCs with intact stem cell properties.	28764802
Periodontal Route of Administration, Tooth structure	Stem Cell Exhaustion	In this study, we verified the ability of dental pulp mesenchymal stem cells (DPSCs) and gingival mesenchymal stem cells (GMSCs) harvested from periodontally affected teeth to produce new mineralized bone tissue in vitro, and compared this to cells from healthy teeth.	28764802
Malignant neoplasm of urinary bladder	Stem Cell Exhaustion	The KMT1A-GATA3-STAT3 Circuit Is a Novel Self-Renewal Signaling of Human Bladder Cancer Stem Cells.	28765327
Malignant neoplasm of urinary bladder, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Bladder cancer stem cells (BCSCs) play a crucial role in tumor initiation, metastasis, and drug resistance.	28765327
Malignant neoplasm of urinary bladder	Stem Cell Exhaustion	Here, we identified a novel signal, the KMT1A-GATA3-STAT3 circuit, which promoted the self-renewal and tumorigenicity of human BCSCs.Experimental Design: In a discovery step, human BCSCs and bladder cancer non-stem cells (BCNSCs) isolated from primary bladder cancer samples #1 and #2, and the bladder cancer cell line EJ were analyzed by transcriptome microarray.	28765327
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	The cancer stem cell (CSC) theory of tumor growth indicates that CSCs within the tumor mass have great capacity to initiate and sustain tumor growth.	28766682
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	Stathmin1 expression is associated with aggressive phenotypes and cancer stem cell marker expression in breast cancer patients.	28766688
Aggressive behavior, Specialty Type - cancer	Stem Cell Exhaustion	High STMN1 expression is a possible marker of breast cancer aggressiveness in association with proliferation, phenotype and cancer stem cell type.	28766688
Degenerative polyarthritis	Stem Cell Exhaustion	Few clinical trials have investigated the safety and efficacy of mesenchymal stem cells for the management of post-traumatic osteoarthritis.	28768528
Glioblastoma Multiforme Pathway, Adult Glioblastoma	Stem Cell Exhaustion	The perivascular niche is critical for intercellular communication between resident cell types in glioblastoma (GBM), and it plays a vital role in maintaining the glioma stem cell (GSC) microenvironment.	28771552
Graft-vs-Host Disease, Tuberculosis, Hepatic	Stem Cell Exhaustion	Concurrent Hepatic Tuberculosis and Hepatic Graft-versus-host Disease in an Allogeneic Hematopoietic Stem Cell Transplant Recipient: A Case Report.	28774674
Graft-vs-Host Disease, Communicable Diseases	Stem Cell Exhaustion	Infection and graft-versus-host disease (GVHD) are among the most common complications after hematopoietic stem cell transplantation (HSCT).	28774674
Childhood Non-Hodgkin Lymphoma, Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	SCHOLAR-1, an international, multicohort retrospective non-Hodgkin lymphoma research study, retrospectively evaluated outcomes in patients with refractory DLBCL which, for this study, was defined as progressive disease or stable disease as best response at any point during chemotherapy (>4 cycles of first-line or 2 cycles of later-line therapy) or relapsed at <=12 months from autologous stem cell transplantation.	28774879
Compression of umbilical cord, Primary Myelofibrosis, PMF Regimen	Stem Cell Exhaustion	BACKGROUND In Primary Myelofibrosis (PMF; a clonal disorder arising from the neoplastic transformation of early hematopoietic stem cells) patients, spinal cord compression (SCC) is a common complication or even a presentation symptom due to extramedullary hematopoiesis (EMH).	28775247
Haiti	Stem Cell Exhaustion	Response to HT first-line therapy (HR 53, 95% CI: 24-120), autologous stem cell transplantation (HR 39, 95% CI: 15-101), and revised International Prognostic Index (HR 22, 95% CI: 11-4*2) were significantly associated with SFT.	28782811
Congestive heart failure, Ventricular Dysfunction	Stem Cell Exhaustion	Thereafter, she had refractory class IV congestive heart failure with severe right ventricular dysfunction, and was deemed unsuitable for stem-cell or heart transplantation.	28784887
Bronchiolitis Obliterans	Stem Cell Exhaustion	Bronchiolitis obliterans syndrome has been associated with increased morbidity and mortality after allogeneic hematopoietic stem cell transplant (HSCT).	28787506
Cardiovascular Diseases	Stem Cell Exhaustion	Endogenous regenerative capacity, assessed as circulating progenitor cell (PC) numbers, is an independent predictor of adverse outcomes in patients with cardiovascular disease.	28790053
Heart failure	Stem Cell Exhaustion	Progenitor Cells and Clinical Outcomes in Patients With Heart Failure.	28790053
NBN wt Allele	Stem Cell Exhaustion	Dermal-derived fibroblasts from NBS patients were reprogrammed into induced pluripotent stem cells (iPSCs) in order to bypass premature senescence.	28790359
Traumatic	Stem Cell Exhaustion	Endothelial Progenitor Cells Correlated with Oxidative Stress after Mild Traumatic Brain Injury.	28792147
Specialty Type - cancer, Refractory Cytopenia of Childhood	Stem Cell Exhaustion	In this study, we showed that Endoglin (CD105) expression not only demarcates a cancer stem cell subpopulation but also confers self-renewal ability and contributes to chemoresistance in RCC.	28793246
Malignant neoplasm of kidney, Resistance Process	Stem Cell Exhaustion	Endoglin Is Essential for the Maintenance of Self-Renewal and Chemoresistance in Renal Cancer Stem Cells.	28793246
Adult Glioblastoma	Stem Cell Exhaustion	The anti-vascular endothelial growth factor receptor-1 monoclonal antibody D16F7 inhibits invasiveness of human glioblastoma and glioblastoma stem cells.	28797294
Mycoses	Stem Cell Exhaustion	Cytomegalovirus Reactivation Is Associated with Increased Risk of Late-Onset Invasive Fungal Disease after Allogeneic Hematopoietic Stem Cell Transplantation: A Multicenter Study in the Current Era of Viral Load Monitoring.	28797778
Opportunistic Infections, Intrinsic Factor Deficiency, Mycoses	Stem Cell Exhaustion	Opportunistic infections such as cytomegalovirus (CMV) reactivation and invasive fungal disease (IFD) cause significant morbidity and mortality to recipients of hematopoietic stem cell transplant (HSCT).	28797778
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Results of a Prospective Randomized, Open-Label, Noninferiority Study of Tbo-Filgrastim (Granix) versus Filgrastim (Neupogen) in Combination with Plerixafor for Autologous Stem Cell Mobilization in Patients with Multiple Myeloma and Non-Hodgkin Lymphoma.	28797783
Lymphoma, Non-Hodgkin, Familial, Morular Metaplasia of the Endometrium, Childhood Non-Hodgkin Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation (auto-HSCT) improves survival in patients with multiple myeloma (MM) and non-Hodgkin lymphoma (NHL).	28797783
Toxic effect	Stem Cell Exhaustion	In retrospective studies, stem cell mobilization with tbo-filgrastim has shown similar efficacy and toxicity as filgrastim, but no prospective studies have been published to date.	28797783
Lymphoma, Non-Hodgkin, Familial	Stem Cell Exhaustion	We have conducted the first prospective randomized trial comparing the safety and efficacy of tbo-filgrastim in combination with plerixafor with that of filgrastim in combination with plerixafor for stem cell mobilization in patients with MM and NHL.	28797783
Lymphoma, Non-Hodgkin, Familial, Morular Metaplasia of the Endometrium	Stem Cell Exhaustion	Tbo-filgrastim is not inferior in efficacy and has similar safety compared to reference filgrastim when used for stem cell mobilization in patients with MM and NHL.	28797783
Lymphoma, Non-Hodgkin, Familial, Morular Metaplasia of the Endometrium	Stem Cell Exhaustion	Granix can be safely used instead of Neupogen for stem cell collection in patients undergoing auto-HSCT for MM or NHL.	28797783
Immunocompromised Host, Communicable Diseases	Stem Cell Exhaustion	Recipients of allogeneic haematopoietic stem cell transplantation (allo-HSCT) are severely immunocompromised and are at increased risk of infection.	28797807
Anemia, Sickle Cell, Acute onset pain	Stem Cell Exhaustion	Acute pain crisis in a patient with sickle cell disease undergoing ovarian simulation for fertility preservation prior to curative stem cell transplantation: case report and literature review.	28801781
Anemia, Sickle Cell, Renal carnitine transport defect	Stem Cell Exhaustion	Hematopoietic stem cell transplantation (HSCT) is a cure for sickle cell disease (SCD) but frequently results in permanent sterility.	28801781
Malignant Neoplasms, Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	Cancer stem cells/cancer-initiating cells (CICs) and their microenvironmental niche play a vital role in malignant tumour recurrence and metastasis.	28802057
Somatic mutation	Stem Cell Exhaustion	Clonal hematopoiesis (CH), as evidenced by recurrent somatic mutations in leukemia-associated genes, commonly occurs among aging human hematopoietic stem cells.	28803919
Hematologic Neoplasms, Neoplasms	Stem Cell Exhaustion	These data suggest that CH occurs in an age-dependent manner and that specific perturbations can enhance fitness of clonal hematopoietic stem cells, which can impact outcome through progression to hematologic malignancies and through cell-non-autonomous effects on solid tumor biology.	28803919
Subependymal Glioma, Neoplasms	Stem Cell Exhaustion	Subependymomas demonstrate mixed populations of cells expressing glial lineage markers as well as putative stem cell markers, suggesting these tumors may arise from multipotent glial progenitors that reside in the subventricular zone.	28804038
Sample Size Calculation	Stem Cell Exhaustion	Gene candidates were identified through microarray experiments performed on Affymetrix GeneChip Human Exon 1.0 ST arrays in endothelial progenitor cell (EPC)-derived endothelial cells (ECs) obtained from patients with SSc-associated PH, patients with SSc without PH, and healthy control subjects.	28805015
Extramedullary, Multiple Myeloma	Stem Cell Exhaustion	Multiple myeloma with extramedullary disease: impact of autologous stem cell transplantation on outcome.	28805789
Multiple Myeloma, Infection, Morular Metaplasia of the Endometrium	Stem Cell Exhaustion	Patients with multiple myeloma (MM) who undergo autologous stem cell transplantation (ASCT) are susceptible to severe infections.	28805791
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	MRP1 protein expression in leukemic stem cells as a negative prognostic marker in acute myeloid leukemia patients.	28805931
Eye	Stem Cell Exhaustion	we report a 13 years old asian male patient rare case of ocular KS that was initiated from the sclera and progressed into the cornea and conjunctiva without an human Immunodeificiency Virus (HIV) or HHV-8 infection after a peripheral blood stem cells transplantation.	28806949
Hair follicle structure	Stem Cell Exhaustion	Stem cells for the epidermis and hair follicle are located in the bulge area of the hair follicle with the potential to differentiate into multiple lineages.	28809777
Skin Squamous Cell Carcinoma or Other Skin Carcinomas TNM Finding v7, Squamous cell carcinoma of skin	Stem Cell Exhaustion	Multiple cutaneous carcinomas, including follicular cutaneous squamous cell carcinoma (FSCC), are thought to arise from stem cells in the follicular bulge.	28809777
Specialty Type - cancer	Stem Cell Exhaustion	Furthermore, ALCAM is considered one of the cancer stem cell markers such as ALDH1 (ALDH1A1) and SALL4.	28811252
Specialty Type - cancer, Malignant Pleural Mesothelioma	Stem Cell Exhaustion	In this study, 175 well-characterized primary diffuse pleural mesotheliomas, including the epithelioid (n = 148), biphasic (n = 15), and sarcomatoid (n = 12) histotypes, were evaluated immunohistochemically for cancer stem cell markers (ALCAM, ALDH1, and SALL4) and PD-L1 expression.	28811252
LMNA wt Allele	Stem Cell Exhaustion	To address this need, we produced a functional three-dimensional model of HGPS that replicates an arteriole-scale tissue engineered blood vessel (TEBV) using induced pluripotent stem cell (iPSC)-derived SMCs from an HGPS patient.	28811655
LMNA wt Allele	Stem Cell Exhaustion	To isolate the effect of the HGPS iSMCs, the endothelial layer consisted of human cord blood-derived endothelial progenitor cells (hCB-EPCs) from a separate, healthy donor.	28811655
Specialty Type - cancer, Ovarian Carcinoma	Stem Cell Exhaustion	CD44 as a cancer stem cell marker and its prognostic value in patients with ovarian carcinoma.	28816557
Epithelial ovarian cancer, Specialty Type - cancer	Stem Cell Exhaustion	The aim of our study was to clarify whether the CD44 adhesion molecule as a cancer stem cell marker could also serve as a prognostic factor in patients with epithelial ovarian cancer (EOC).	28816557
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells (CSCs) are subpopulations of cells with typical characteristics of stem cells - i.e.	28816557
Central neuroblastoma	Stem Cell Exhaustion	The patient underwent treatment for high-risk neuroblastoma comprising chemotherapy including cisplatin, etoposide, vindesine, dacarbacine, ifosfamide, vincristine, adriamycine and autologous stem cell transplantation followed by maintenance therapy with 13-cis retinoic acid (GPOH NB2004 High Risk Trial Protocol) and is in complete long-term remission.	28818093
Takotsubo Cardiomyopathy	Stem Cell Exhaustion	Catecholamine-Dependent b-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy.	28818208
Medial collateral ligament	Stem Cell Exhaustion	In conclusion, we show that TP53 mutations identify a phenotypically distinct and highly aggressive form of MCL with poor or no response to regimens including cytarabine, rituximab, and autologous stem-cell transplant (ASCT).	28819011
Graft-vs-Host Disease	Stem Cell Exhaustion	Graft-versus-host disease (GVHD) is a leading cause of morbidity and mortality in allogeneic hematopoietic stem cell transplantation (alloHCT).	28821454
Chronic Kidney Disease, CTCAE	Stem Cell Exhaustion	Chronic Kidney Disease in Long-Term Survivors after Allogeneic Hematopoietic Stem Cell Transplantation: Retrospective Analysis at a Single Institute.	28822830
Chronic Kidney Diseases	Stem Cell Exhaustion	Conditioning regimen, stem cell source, or the presence of acute/chronic GVHD was not significantly associated with CKD in this study.	28822830
Sweet Syndrome, Primary Myelofibrosis	Stem Cell Exhaustion	Recurrent Subcutaneous Sweet's Disease in a Myelofibrosis Patient Treated with Ruxolitinib before Allogeneic Stem Cell Transplantation.	28824063
Treatment related secondary malignancy, Primary Myelofibrosis	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (allo-SCT) has a curative potential for myelofibrosis (MF) patients; however, its association with a high therapy-related mortality (TRM) remains a big obstacle that needs to be overcome.	28824063
Pregnancy Complications, Infectious, Multiple Myeloma	Stem Cell Exhaustion	Infectious complications in multiple myeloma receiving autologous stem cell transplantation in the past 10 years.	28825207
Morular Metaplasia of the Endometrium, Multiple Myeloma, Communicable Diseases	Stem Cell Exhaustion	Infection is one of the main causes of early-treatment mortality in multiple myeloma (MM) patients during autologous stem cell transplantation (autoSCT).	28825207
COL4A2 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	We report a case of cutaneous ICH occurring after allogeneic hematopoietic stem-cell transplantation for a myelodysplastic syndrome in a 56-year-old man.	28825606
COL4A2 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	This case broadens the spectrum of complications after stem-cell transplantation and demonstrates that cutaneous ICH in the setting of myelodysplastic syndromes may have a nonrelated origin to dysplastic myeloid cells.	28825606
Graft-vs-Host Disease	Stem Cell Exhaustion	Minor histocompatibility antigen (miHA) mismatches have been related to graft-versus-host disease (GVHD) after allogeneic stem cell transplantation, but this association remains controversial due to the lack of consistency in the results obtained by different groups.	28827064
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	Polymorphisms of the stem cell marker gene CD133 are associated the clinical outcome in a cohort of Chinese non-small cell lung cancer patients.	28827262
Parkinson Disease	Stem Cell Exhaustion	To examine the pathogenic role of a-synuclein (aS) in Parkinson's Disease, we have generated induced Pluripotent Stem Cell lines from early onset Parkinson's Disease patients with SNCA A53T and SNCA Triplication mutations, and in this study have differentiated them to PSC-macrophages (pMac), which recapitulate many features of their brain-resident cousins, microglia.	28827786
Fibrosis Assessment	Stem Cell Exhaustion	Multipotent mesenchymal stem cells in lung fibrosis.	28827799
Lung diseases	Stem Cell Exhaustion	Stem cells have been identified in the human lung; however, their role in lung disease is not clear.	28827799
Structure of parenchyma of lung	Stem Cell Exhaustion	We aimed to isolate mesenchymal stem cells (MSC) from human lung tissue and to study their in vitro properties.	28827799
Gastric Adenocarcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Systemic Inflammation Response Index (SIRI), cancer stem cells and survival of localised gastric adenocarcinoma after curative resection.	28828692
Malignant neoplasm of stomach, Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells (CSCs) can contribute to gastric cancer progression and recurrence.	28828692
methyldopa	Stem Cell Exhaustion	Extensive preclinical studies of stem cell replacement therapies for AMD involve the transplantation of stem cell-derived RPE cells into the subretinal space of animal models, in which the subretinal injection technique is applied.	28829422
Specialty Type - cancer	Stem Cell Exhaustion	We developed a panel of patient-derived mouse orthotopic xenografts (PDOX) for preclinical drug studies by implanting cancer stem cells (CSC) cultured from fresh surgical specimens intracranially into 8-wk-old female athymic nude mice.	28830577
Prostate carcinoma	Stem Cell Exhaustion	We aimed to investigate the immunohistochemical expression of epithelial-mesenchymal transition (EMT)-related molecules (Twist-1 and E-cadherin) and the stem cell marker EZH2 in prostate cancer and to assess their ability to identify the high-risk patients, in a trial to explore their prognostic implications.	28832071
Crabs	Stem Cell Exhaustion	Among 623 patients, the triplet group (n=146 [23%]) was younger (65.2 vs 69.8 years) and more likely to have high-risk relapse (67% vs 50%), CRAB symptoms (94.5% vs 81.1%), triplet first-line treatment (75% vs 51%) and frontline stem cell transplant (38% vs 20%) (P<0.001 for all).	28833305
Meningioma	Stem Cell Exhaustion	We detected c-Kit expression in a minority of the melanocytes as well as stem cell factor and basic fibroblast growth factor in the meningioma cells, suggesting that mechanisms implicated in normal melanocyte migration may be involved.	28833600
Hemophilia A	Stem Cell Exhaustion	Methods Using fibroblasts from skin biopsies of a previously identified hemophilic patient bearing the F9 c.278-3A>G mutation and his mother, we generated induced pluripotent stem cells (iPSCs).	28834196
Failure	Stem Cell Exhaustion	Relapse has emerged as the most important cause of treatment failure after allogeneic hematopoietic stem cell transplantation (HSCT).	28835441
Infection	Stem Cell Exhaustion	Two patients received autologous peripheral blood stem cell transplantation after bortezomib, which led to fatal infections.	28836002
diabetic	Stem Cell Exhaustion	Periodontal treatment modulates gene expression of endothelial progenitor cells in diabetic patients.	28836285
diabetic	Stem Cell Exhaustion	This study investigated the effects of periodontal treatment on immuno-inflammatory gene expression of endothelial progenitor cells (EPCs) in diabetic patients.	28836285
Cryptorchidism	Stem Cell Exhaustion	In nonsyndromic cryptorchidism PLAP-positive undifferentiated spermatogonial stem cells persisted in a significant proportion of nontreated undescended testes and they will be especially sensitive to long-lasting abnormally high temperature that may be the single most important cause facilitating the accumulation of mutations during cell replication and the development of ITGCN to be prevented by orchiopexy.	28838001
Inflammation, diabetic	Stem Cell Exhaustion	Comparison of Ticagrelor Versus Prasugrel for Inflammation, Vascular Function, and Circulating Endothelial Progenitor Cells in Diabetic Patients With Non-ST-Segment Elevation Acute Coronary Syndrome Requiring Coronary Stenting: A Prospective, Randomized, Crossover Trial.	28838475
Inflammation	Stem Cell Exhaustion	This study compared adenosine-associated pleiotropic effects of the 2 P2Y12 receptor antagonists on vascular function, systemic inflammation, and circulating endothelial progenitor cells (EPCs).	28838475
Arterial Stiffness, Inflammation, diabetic, Acute Coronary Syndrome	Stem Cell Exhaustion	(Comparison of Ticagrelor vs. Prasugrel on Inflammation, Arterial Stiffness, Endothelial Function, and Circulating Endothelial Progenitor Cells in Diabetic Patients With Non-ST Elevation Acute Coronary Syndrome [NSTE-ACS] Requiring Coronary Stenting; NCT02487732).	28838475
Multiple Myeloma	Stem Cell Exhaustion	We assessed the ability of a mass spectrometry-based technique, called monoclonal immunoglobulin rapid accurate mass measurement (miRAMM), to extend the analytical range of M-protein detection in serum samples obtained from myeloma patients in stringent complete response (sCR) post-autologous stem cell transplant (ASCT).	28841203
Lymphoma, Multiple Myeloma	Stem Cell Exhaustion	Cytomegalovirus reactivation in lymphoma and myeloma patients undergoing autologous peripheral blood stem cell transplantation.	28843110
Sepsis, Specialty Type - cancer, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Patients with AML had a higher sepsis incidence and higher mortality rates overall, especially in relation to stem-cell transplant recipients and those with other types of cancer.	28844403
Osteoporosis	Stem Cell Exhaustion	Transcriptional profiling of human femoral mesenchymal stem cells in osteoporosis and its association with adipogenesis.	28844671
BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 20, Osteoporosis	Stem Cell Exhaustion	Osteoblasts and adipocytes share a common origin, mesenchymal stem cells (MSCs), and their genetic determinants might be important in the relationship between osteoporosis and obesity.	28844671
Toxic effect	Stem Cell Exhaustion	Impact of Fluid Overload as New Toxicity Category on Hematopoietic Stem Cell Transplantation Outcomes.	28844946
Aplastic Anemia	Stem Cell Exhaustion	Outcome of Second Transplantation Using Umbilical Cord Blood for Graft Failure after Allogeneic Hematopoietic Stem Cell Transplantation for Aplastic Anemia.	28844947
Aplastic Anemia	Stem Cell Exhaustion	Graft failure (GF) is the most critical life-threatening complication of allogeneic hematopoietic stem cell transplantation (HSCT) for aplastic anemia, for which a second transplantation is the only effective treatment.	28844947
Aplastic Anemia	Stem Cell Exhaustion	Although further investigation is needed, umbilical cord blood could be an effective and promising option for stem cell source for urgent second transplantation in patients with aplastic anemia who develop GF after the first HSCT.	28844947
Neutropenia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This prospective study included 87 adult hematological patients at the start of febrile neutropenia after intensive chemotherapy for acute myeloid leukemia or after autologous stem cell transplantation.	28845081
Degenerative disorder	Stem Cell Exhaustion	Induced pluripotent stem cells (iPSCs), which are used to produce transplantable tissues, may particularly benefit older patients, who are more likely to suffer from degenerative diseases.	28846095
Lymphoma	Stem Cell Exhaustion	Lack of a Prognostic Impact of the MyD88 L265P Mutation for Diffuse Large B Cell Lymphoma Patients Undergoing Autologous Stem Cell Transplantation.	28847710
Nausea, Chemotherapy-induced Nausea and Vomiting Questionnaire	Stem Cell Exhaustion	Our data indicated that the addition of aprepitant for CINV prophylaxis during HDCT reduced the incidence of severe nausea and might also provide economic benefit in the overall management of HDCT prior to autologous peripheral blood stem cell transplantation.	28848220
Multiple Myeloma	Stem Cell Exhaustion	Outcomes of maintenance therapy with lenalidomide or bortezomib in multiple myeloma in the setting of early autologous stem cell transplantation.	28848227
Specialty Type - cancer	Stem Cell Exhaustion	YAP signaling in gastric cancer-derived mesenchymal stem cells is critical for its promoting role in cancer progression.	28848999
Neoplasms	Stem Cell Exhaustion	Cancer-associated mesenchymal stem cells (MSCs) are critically involved in tumor development and progression.	28848999
Malignant neoplasm of stomach	Stem Cell Exhaustion	Herein, we reported that the expression of Yes-associated protein 1 (YAP) was higher in gastric cancer derived mesenchymal stem cells (GC-MSCs) than that in bone marrow derived MSCs (BM-MSCs).	28848999
Chronic Obstructive Airway Disease, Impaired T cell function	Stem Cell Exhaustion	Endothelial progenitor cell dysfunction in acute exacerbation of chronic obstructive pulmonary disease.	28849108
Chronic Obstructive Airway Disease, Cardiac dysfunction	Stem Cell Exhaustion	Endothelial progenitor cells (EPCs) are decreased in cardiac dysfunction morbidity associated with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).	28849108
Toxic effect	Stem Cell Exhaustion	We studied early potential treosulfan-related toxicity in 118 patients treated with treosulfan-based conditioning before allogeneic hematopoietic stem-cell transplantation.	28849374
Amyloidosis	Stem Cell Exhaustion	An observational study was conducted to assess health-related quality of life (HRQoL) in patients treated for AL amyloidosis between 1994 and 2014 with both high dose melphalan and stem cell transplantation (HDM/SCT) or non-SCT chemotherapy regimens.	28850697
CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology	Stem Cell Exhaustion	In the R/R setting, there was no survival difference between IST and allogeneic stem cell transplant groups, with a trend toward superior OS in the former.	28850699
Malignant neoplasm of ovary, Specialty Type - cancer	Stem Cell Exhaustion	Aldehyde dehydrogenase-1A1 (ALDH1A1), CD133, CD44, and CD24 have been reported as cancer stem cell markers in ovarian cancers.	28851663
Stable chronic Graft vs Host Disease	Stem Cell Exhaustion	We conducted ex vivo activation and signaling assays of 30 primary samples from hematopoietic stem cell transplantation patients with and without cGVHD.	28851699
Neoplasms	Stem Cell Exhaustion	Using paired differentiated and stem cell primary cultures, we investigated the association of SHP2 expression with the tumor stem cell compartment.	28852935
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	SHP2 regulates proliferation and tumorigenicity of glioma stem cells.	28852935
Glioblastoma Multiforme Pathway	Stem Cell Exhaustion	Given the importance of SHP2 in developing neural stem cells, and the importance of glioma stem cells (GSCs) in GBM oncogenesis, we explored the functional role of SHP2 in GSCs.	28852935
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	Pre-transplant PET/CT may be prognostic in diffuse large B-cell lymphoma (DLBCL) patients undergoing autologous stem cell transplantation (ASCT).	28853617
Hirschsprung Disease, Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	There have not been any previously reported cases of near total intestinal aganglionosis complicated by concerns for hemophagocytic lymphohistiocytosis and need for both multivisceral organ transplant and hematopoietic stem cell transplant.	28854959
Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	He presents a complex challenge creating difficulty with management of whether to proceed with bowel transplant as a result of near-total intestinal aganglionosis or hematopoietic stem cell transplant for treatment of hemophagocytic lymphohistiocytosis.	28854959
Ischemia	Stem Cell Exhaustion	Circulating GDF15 levels were measured using a multiplex immunoassay in patients with critical limb ischemia and PAD from 2 different patient cohorts that included patients with clinically manifest PAD: the JUVENTAS (Rejuvenating Endothelial Progenitor Cells via Transcutaneous Intra-Arterial Supplementation) trial (n=160, 67 major events; critical limb ischemia) and the Athero-Express Biobank (n=386, 64 major events; PAD).	28855167
Impaired, Impaired cognition, "Alzheimers Disease	Stem Cell Exhaustion	In this regard, new evidence linking Alzheimer's disease-related pathology and neuronal stem cells suggests that hippocampal neurogenesis impairment is an important factor underlying these cognitive deficits.	28855626
Specialty Type - cancer, Head and Neck Carcinoma	Stem Cell Exhaustion	The effect of targeted therapy on recruited cancer stem cells in a head and neck carcinoma model.	28857306
Malignant Head and Neck Neoplasm, Specialty Type - cancer, MMP8 protein, human	Stem Cell Exhaustion	Head and neck cancers (HNC) are known for their repopulation ability driven by cancer stem cells (CSCs).	28857306
Specialty Type - cancer	Stem Cell Exhaustion	The fate of both cycling and quiescent cancer stem cells is assessed.	28857306
Specialty Type - cancer	Stem Cell Exhaustion	The Linear Quadratic model is used to simulate radiotherapy, while cellular recruitment and the effects of ATRA on cancer stem cells are modelled based on literature data.	28857306
BCR gene	Stem Cell Exhaustion	Before consolidation or allogeneic stem cell transplantation (allo-HSCT), negative Flow-MRD was associated with improved survival (p = .019 and .041, respectively) for Ph- ALL patients, but not for Ph+ ALL (p = .111 and .812, respectively).	28857648
palladium, Parkinson Disease	Stem Cell Exhaustion	Induced pluripotent stem cells (iPS cells) are a promising source for a cell-based therapy to treat Parkinson's disease (PD), in which midbrain dopaminergic neurons progressively degenerate.	28858313
palladium	Stem Cell Exhaustion	Here we show that human iPS cell-derived dopaminergic progenitor cells survived and functioned as midbrain dopaminergic neurons in a primate model of PD (Macaca fascicularis) treated with the neurotoxin MPTP.	28858313
Thrombotic Microangiopathies	Stem Cell Exhaustion	Thrombotic Microangiopathy after Allogeneic Stem Cell Transplantation: A Comparison of Eculizumab Therapy and Conventional Therapy.	28860002
Acute GVH disease	Stem Cell Exhaustion	Soluble Interleukin-7 receptor levels and risk of acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation.	28863969
Graft-vs-Host Disease	Stem Cell Exhaustion	The composite endpoint graft-versus-host disease (GVHD)-free, relapse-free survival (GRFS) has recently been introduced as a tool to assess the success of allogeneic hematopoietic stem cell transplantation (HSCT) and has been incorporated into recent randomized trials of GVHD prophylaxis by the Blood and Marrow Transplant Clinical Trials Network.	28864140
GJB2 wt Allele	Stem Cell Exhaustion	In the HID group, 86 patients (54%) received peripheral blood stem cells as the graft source.	28864140
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Haploidentical Hematopoietic Stem Cell Transplantation for Myelodysplastic Syndrome.	28865971
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	This study aimed to validate the capability of the Center for International Blood and Marrow Transplant Research (CIBMTR) prognostic scoring system to predict outcomes of patients with myelodysplastic syndromes (MDS) who had undergone HLA-haploidentical related donor hematopoietic stem cell transplantation (haplo-HSCT).	28865971
Amyloidosis	Stem Cell Exhaustion	High-Dose Melphalan and Stem Cell Transplantation in Patients on Dialysis Due to Immunoglobulin Light-Chain Amyloidosis and Monoclonal Immunoglobulin Deposition Disease.	28865972
Amyloidosis, Organ Dysfunction Scores	Stem Cell Exhaustion	High-dose melphalan and stem cell transplantation (HDM/SCT) is effective for selected patients with AL amyloidosis, with high rates of complete hematologic response and potential for improved organ dysfunction.	28865972
SERPINB3 wt Allele, Specialty Type - cancer, Squamous cell carcinoma	Stem Cell Exhaustion	The objective of this study was to explore the prognostic value of cancer stem cell markers, namely CD133, NANOG, and NOTCH1, in early stage oral squamous cell carcinoma (OSCC).	28866747
Lymphoma	Stem Cell Exhaustion	Prolonged hospitalization, primary refractory disease, performance status and age are prognostic factors for survival in patients with diffuse large B-cell lymphoma and transformed indolent lymphoma undergoing autologous stem cell transplantation.	28868963
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	In patients with relapsed diffuse large B-cell lymphoma (DLBCL), high-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is standard treatment.	28868963
Skeletal muscle hypertrophy	Stem Cell Exhaustion	Likewise, aged individuals demonstrated an impaired response to re-loading reflected by attenuated gains in myofibre area, in parallel with smaller increases in satellite cell number despite no age-related differences were observed in factors known to promote skeletal muscle hypertrophy and myogenic stem cell proliferation (IGF-Ea, MGF, MyoD, myogenin, HGF).	28869034
Carcinogenesis	Stem Cell Exhaustion	The signature regulated signaling pathways including Calcium, MAPK, ErbB, mTOR and cell cycle involved in carcinogenesis from glial progenitor cell to primary GBM.	28869437
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Age does not adversely influence outcomes among patients older than 60 years who undergo allogeneic hematopoietic stem cell transplant for AML and myelodysplastic syndrome.	28869613
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplant (AHSCT) outcomes data of older AML/myelodysplastic syndrome (MDS) patients are limited.	28869613
Multiple Myeloma	Stem Cell Exhaustion	A phase 1 trial of 90Y-Zevalin radioimmunotherapy with autologous stem cell transplant for multiple myeloma.	28869617
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	This phase 1 study (clinical trial NCT00477815) was conducted to determine the maximum tolerated dose (MTD) of yttrium-90 ibritumomab tiuxetan (90Y-Zevalin) with high dose melphalan (HDM) therapy in multiple myeloma (MM) patients undergoing autologous stem cell transplantation (ASCT).	28869617
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	High-dose Thiotepa, Busulfan, Cyclophosphamide, and Autologous Stem Cell Transplantation as Upfront Consolidation for Systemic Non-Hodgkin Lymphoma With Synchronous Central Nervous System Involvement.	28870642
Liver carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Expression of Cancer Stem Cell-associated DKK1 mRNA Serves as Prognostic Marker for Hepatocellular Carcinoma.	28870909
Liver carcinoma, Specialty Type - cancer, Hollings Cancer Center	Stem Cell Exhaustion	Cancer stem cells (CSCs) are associated with prognosis of hepatocellular carcinoma (HCC).	28870909
Neoplasms	Stem Cell Exhaustion	Second neoplasms in adult patients submitted to haematopoietic stem cell transplantation.	28874263
Neoplasms	Stem Cell Exhaustion	Patients submitted to haematopoietic stem cell transplantation (HSCT) are at increased risk of late complications, such as second neoplasm (SN).	28874263
Glioblastoma Multiforme Pathway, Behavior	Stem Cell Exhaustion	Although the mechanistic aspects of GJIC have been extensively studied, the role of connexins in the regulation of the malignant behavior of glioma stem cells (GSCs) remains unclear.	28875331
Drusen, FUNDUS DYSTROPHY, PSEUDOINFLAMMATORY, OF SORSBY, Dopa-Responsive Dystonia, Autosome	Stem Cell Exhaustion	Here, we use human induced pluripotent stem cell-retinal pigment epithelium (hiPSC-RPE) derived from patients with three dominant MDs, Sorsby's fundus dystrophy (SFD), Doyne honeycomb retinal dystrophy/malattia Leventinese (DHRD), and autosomal dominant radial drusen (ADRD), and demonstrate that dysfunction of RPE cells alone is sufficient for the initiation of sub-RPE lipoproteinaceous deposit (drusen) formation and extracellular matrix (ECM) alteration in these diseases.	28878022
Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Filgrastim is usually combined with chemotherapy to mobilize hematopoietic progenitor cells in non-Hodgkin lymphoma (NHL) patients.	28879595
Heart failure, Myocardial Ischemia	Stem Cell Exhaustion	The present first-in-human clinical trial evaluated the safety and feasibility of a newly developed and cryopreserved Cardiology Stem Cell Centre adipose-derived stromal cell (CSCC_ASC) product from healthy donors for intramyocardial injection in ten patients with ischemic heart disease and ischemic heart failure (IHF).	28880460
Shock, Cardiogenic	Stem Cell Exhaustion	A dual therapy of off-pump temporary left ventricular extracorporeal device and amniotic stem cell for cardiogenic shock.	28882138
Shock, Cardiogenic	Stem Cell Exhaustion	Temporary mechanical circulatory support device without sternotomy has been highly advocated for severe cardiogenic shock patient but little is known when coupled with amniotic stem cell therapy.	28882138
Shock, Cardiogenic	Stem Cell Exhaustion	This case reports the first dual therapy of temporary left ventricular extracorporeal device CentriMag with distal banding technique and human amniotic stem cell injection for treating a severe refractory cardiogenic shock of an 68-year-old female patient.	28882138
Myocardial Reperfusion	Stem Cell Exhaustion	The concomitant use of the temporary minimally-invasive off-pump CentriMag placement and stem cell therapy not only provided an alternative to cardiopulmonary bypass and full-median sternotomy procedures but may have also synergistically enhanced myocardial reperfusion and regeneration.	28882138
Acute leukemia	Stem Cell Exhaustion	Human leukocyte antigen-E mismatch is associated with better hematopoietic stem cell transplantation outcome in acute leukemia patients.	28883078
Malignant lymphoma of testis	Stem Cell Exhaustion	High-dose chemotherapy with autologous stem cell transplantation following systemic chemotherapy, prophylactic intrathecal methotrexate, and radiotherapy prevents relapse and improves the outcome of advanced stage primary testicular lymphoma even with cardiac involvement.	28883219
ACAA1 gene	Stem Cell Exhaustion	We herein report an extremely rare case of advanced stage PTL with cardiac involvement, treated by high-dose chemotherapy with autologous stem cell transplantation (HDT-ASCT) followed by systemic chemotherapy, prophylactic intrathecal methotrexate (IT-MTX), and radiotherapy.	28883219
Specialty Type - cancer	Stem Cell Exhaustion	Cancer may arise from dedifferentiation of mature cells or maturation-arrested stem cells.	28883415
Specialty Type - cancer	Stem Cell Exhaustion	The resected specimens were analyzed for associations with clinicopathological data, including DCLK1 expression, epithelial mesenchymal transition (EMT) marker expression, and cancer stem cell (CSC) marker expression.	28883702
TNF protein, human	Stem Cell Exhaustion	They also displayed higher expressions of embryonic stem cell marker OCT3/4 and osteogenic factors Wnt3a, b-catenin, and microRNA-29a (miR-29a), concomitant with lower expressions of joint-deleterious factors HDAC4, TGF-b1, IL-1b, TNF-a, and MMP3, in comparison with those of BMMSCs.	28884332
leukemia	Stem Cell Exhaustion	Severe Mucha-Habermann-Like Ulceronecrotic Skin Disease in T-Cell Acute Lymphoblastic Leukemia Responsive to Basiliximab and Stem Cell Transplant.	28884915
Leukemia, Myelomonocytic, Chronic, Myeloproliferation, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	Chronic myelomonocytic leukemia (CMML) is a hematopoietic stem cell neoplasm exhibiting both myelodysplastic and myeloproliferative features.	28885734
Anemia, Sickle Cell, Renal carnitine transport defect	Stem Cell Exhaustion	Novel curative therapies using genetic transfer of normal globin-producing genes into autologous hematopoietic stem cells (HSCs) are in clinical trials for patients with sickle cell disease (SCD).	28887325
Pulmonary Complication	Stem Cell Exhaustion	Late-onset non-infectious pulmonary complications (LONIPCs) contribute to higher morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT).	28888028
Specialty Type - cancer	Stem Cell Exhaustion	The rate of CD44v9-positive cases, a cancer stem cell marker, was assessed in C-IV/C-V samples with immunohistochemical staining.	28890117
Specialty Type - cancer, Malignant neoplasm of stomach, Neoplasms	Stem Cell Exhaustion	These data suggest that cancer cells, including cancer stem cells, in early gastric cancers are easily detached via contact with the tumor surface.	28890117
Myopathy, Impaired T cell function	Stem Cell Exhaustion	In many muscle disorders, the repeated cycles of damage and repair lead to stem cell dysfunction.	28890163
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Validation of the revised IPSS at transplant in patients with myelodysplastic syndrome/transformed acute myelogenous leukemia receiving allogeneic stem cell transplantation: a retrospective analysis of the EBMT chronic malignancies working party.	28892084
Corneal Endothelial Cell Loss	Stem Cell Exhaustion	Circulating endothelial cell count: a reliable marker of endothelial damage in patients undergoing hematopoietic stem cell transplantation.	28892085
Multiple Myeloma	Stem Cell Exhaustion	Allogeneic stem cell transplantation and subsequent treatments as a comprehensive strategy for long-term survival of multiple myeloma patients.	28892086
Crohn Disease	Stem Cell Exhaustion	Living with Crohn's disease: an exploratory cross-sectional qualitative study into decision-making and expectations in relation to autologous haematopoietic stem cell treatment (the DECIDES study).	28893742
Crohn Disease	Stem Cell Exhaustion	Decision-making and expectations of people with severe Crohn's disease in relation to autologous haematopoietic stem cell treatment is a complex process influenced by participants' histories of battling with their condition, a frequent willingness to consider novel treatment options despite potential risks and, in some cases, a raised level of expectation about the benefits of trial participation.	28893742
Malignant Neoplasms, Carcinoma of larynx	Stem Cell Exhaustion	NANOG is a master regulator of embryonic stem cell pluripotency, found to be frequently aberrantly expressed in a variety of cancers, including laryngeal carcinomas.	28894270
Multiple Myeloma	Stem Cell Exhaustion	Inpatient vs outpatient autologous hematopoietic stem cell transplantation for multiple myeloma.	28895206
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy and autologous hematopoietic stem cell transplantation (auto-HCT) are commonly performed for multiple myeloma (MM) patients and may be as safe in the outpatient setting as in the inpatient setting.	28895206
Hodgkin Disease	Stem Cell Exhaustion	Prognostic Model to Predict Post-Autologous Stem-Cell Transplantation Outcomes in Classical Hodgkin Lymphoma.	28898161
Hodgkin Disease	Stem Cell Exhaustion	Purpose Our aim was to capture the biology of classical Hodgkin lymphoma (cHL) at the time of relapse and discover novel and robust biomarkers that predict outcomes after autologous stem-cell transplantation (ASCT).	28898161
Specialty Type - cancer	Stem Cell Exhaustion	After retrospective analysis of the cancer samples of patients who received esophagectomy, we found the relevance between ratio of either ALDH1 or CD133-positive cancer stem cells and 2-year recurrence.	28902370
Esophageal carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Higher ratios of cancer stem cells indicated later clinical stages, and Wnt signaling activation was more frequent in later esophageal carcinoma.	28902370
Esophageal Neoplasms	Stem Cell Exhaustion	Further in bench studies, we explored the suppressive roles and the mechanisms involved in Let-7 on self-renewal in ECA-109 and ECA-9706 esophageal cancer stem cells.	28902370
Specialty Type - cancer	Stem Cell Exhaustion	Isolated cancer stem cells naturally divide symmetrically and are therapy resistant.	28902370
Specialty Type - cancer	Stem Cell Exhaustion	Therapy of fluorouracil and docetaxel both enriched the stem cells, proving the resistant characteristics of cancer stem cells.	28902370
Specialty Type - cancer, Esophageal Neoplasms	Stem Cell Exhaustion	These results identified the crucial participation of stem cells in esophageal cancer occurrence and progression as the potent indicator, and also indicate the potential powerful agent of Let-7 nano-particles in treatment of cancer.	28902370
Drug-induced immune hemolytic anemia, Decreased platelet count, Drug-induced	Stem Cell Exhaustion	Drug-induced immune hemolytic anemia (DIIHA) and drug-induced immune thrombocytopenia (DIIT) are rare but dangerous complications of pharmacotherapy that may be underrecognized in hematopoietic stem cell transplant (HSCT) patients due to overlap of signs and symptoms with those of more common disease processes.	28905389
Specialty Type - cancer, Ovarian Serous Tumor	Stem Cell Exhaustion	Cancer Stem Cell-Related Marker NANOG Expression in Ovarian Serous Tumors: A Clinicopathological Study of 159 Cases.	28906309
Specialty Type - cancer, Ovarian Serous Adenocarcinoma, Ovarian Serous Tumor	Stem Cell Exhaustion	The objectives of this study were to assess cancer stem cell-related marker NANOG expression in ovarian serous tumors and to evaluate its prognostic significance in relation to ovarian serous carcinoma.	28906309
Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Fludarabine/busulfan-based conditioning regimens are widely used to perform allogeneic stem-cell transplantation (allo-SCT) in high-risk non-Hodgkin lymphoma (NHL) patients.	28911060
methyldopa	Stem Cell Exhaustion	We have derived and characterized induced pluripotent stem cell (iPSC) lines from two subjects without AMD and low-risk genotype and two patients with advanced AMD and high-risk genotype and generated RPE cells that show local secretion of several proteins involved in the complement pathway including factor H, factor I, and factor H-like protein 1.	28913923
Ischemic stroke	Stem Cell Exhaustion	Age of donor of human mesenchymal stem cells affects structural and functional recovery after cell therapy following ischaemic stroke.	28914133
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic stem cell transplantation with HLA-matched donors is increasingly used for older patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).	28918304
Multiple Myeloma	Stem Cell Exhaustion	Symptom experience of multiple myeloma (syMMex) patients treated with autologous stem cell transplantation following high-dose melphalan: a descriptive longitudinal study.	28918604
Coronary Arteriosclerosis, Acute myocardial infarction	Stem Cell Exhaustion	Mobilization of endothelial progenitor cells (EPCs) into circulation from bone marrow in patients with acute myocardial infarction has strong scientific evidence; less is known about EPC mobilization in patients with stable coronary artery disease (CAD).	28918896
Degenerative polyarthritis	Stem Cell Exhaustion	Resident platelet-derived growth factor receptor a-positive mesenchymal progenitor cells contributed to ectopic adipogenesis in vastus medialis muscles of OA patients.	28919112
Neutropenia	Stem Cell Exhaustion	Diagnostic value of sTREM-1, IL-8, PCT, and CRP in febrile neutropenia after autologous stem cell transplantation.	28920169
Infection, Febrile Neutropenia, Pregnancy Complications, Infectious	Stem Cell Exhaustion	Infections and infectious complications are the major cause of morbidity and mortality in febrile neutropenic patients after autologous stem cell transplantation.	28920169
Neutropenia, Febrile Neutropenia	Stem Cell Exhaustion	Here, to assess the utility of PCT, CRP, IL-8, and sTREM-1 in febrile neutropenia, 44 patients presenting with febrile neutropenia after autologous stem cell transplantation were recruited in a single-center prospective pilot study.	28920169
Malignant neoplasm of lung	Stem Cell Exhaustion	Maximized nanodrug-loaded mesenchymal stem cells by a dual drug-loaded mode for the systemic treatment of metastatic lung cancer.	28920712
Corneal Neovascularization	Stem Cell Exhaustion	Thus, we evaluated corneal neovascularization in patients with limbal stem cell deficiency using optical coherence tomography angiography (OCTA).	28922332
Cardiomyopathies	Stem Cell Exhaustion	Dose Comparison Study of Allogeneic Mesenchymal Stem Cells in Patients With Ischemic Cardiomyopathy (The TRIDENT Study).	28923793
Ischemic cardiomyopathy	Stem Cell Exhaustion	To compare the safety and efficacy of 2 doses of allogeneic bone marrow-derived human mesenchymal stem cells identically delivered in patients with ischemic cardiomyopathy.	28923793
Ischemic cardiomyopathy	Stem Cell Exhaustion	Thirty patients with ischemic cardiomyopathy received in a blinded manner either 20 million (n=15) or 100 million (n=15) allogeneic human mesenchymal stem cells via transendocardial injection (0.5 cc per injection x 10 injections per patient).	28923793
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic graft-versus-host disease (cGVHD) is a serious complication of allogeneic stem cell transplantation with few effective options available after failure of corticosteroids.	28924018
Infection	Stem Cell Exhaustion	Prospective evaluation of the SeptiFAST multiplex real-time PCR assay for surveillance and diagnosis of infections in haematological patients after allogeneic stem cell transplantation compared to routine microbiological assays and an in-house real-time PCR method.	28925082
Parkinson Disease	Stem Cell Exhaustion	Establishment of an induced pluripotent stem cell line ZZUi003-A from a 65-year-old male with sporadic Parkinson's disease.	28925360
Diabetes Mellitus, Non-Insulin-Dependent	Stem Cell Exhaustion	Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 13 (MODY13) with a the potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) mutation.	28925365
Study Day of Morphology Assessment	Stem Cell Exhaustion	We generated induced pluripotent stem cells (iPSCs) from a patient with KCNJ11p.Glu227Lys mutation who developed MODY at 13years old.	28925365
Marfan Syndrome	Stem Cell Exhaustion	A Marfan syndrome human induced pluripotent stem cell line with a heterozygous FBN1 c.4082G>A mutation, ISMMSi002-B, for disease modeling.	28925368
Brain Injuries, Seizures	Stem Cell Exhaustion	Nestin is expressed in immature neuroepithelial and progenitor cell types and transiently upregulated in proliferative neuroglial cells responding to acute brain injury, including following seizures.	28925561
Specialty Type - cancer	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) display pleiotropic functions, which include secretion of soluble factors with immunosuppressive activity implicated in cancer progression.	28930684
Malignant Neoplasms	Stem Cell Exhaustion	Patients receiving hematopoietic stem cell transplants (HSCT) 29/60 (48%) or with a hematologic malignancy 17/60 (28%) accounted for the majority of DEC cases.	28931467
Specialty Type - cancer	Stem Cell Exhaustion	BMI-1 plays a key role in biology of stem cells including cancer stem cells by regulation of their self-renewal and differentiation.	28931748
Specialty Type - cancer	Stem Cell Exhaustion	Taking into account significant role of BMI1 in tumorigenesis, especially associated with cancer stem cells, it seems that this gene may be a promising target of anticancer therapies.	28931748
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	This study describes short-term and long-term healthcare resource utilization (HRU) and costs following an allogeneic hematopoietic stem cell transplant (HSCT) in adult patients with diffuse large B-cell lymphoma (DLBCL) in a real-world setting.	28933643
Chronic graft-versus-host disease	Stem Cell Exhaustion	Characteristics and risk of chronic graft-versus-host disease of liver in allogeneic hematopoietic stem cell transplant recipients.	28934311
Graft-vs-Host Disease, Stable chronic Graft vs Host Disease	Stem Cell Exhaustion	Chronic graft-versus-host-disease (cGvHD) is a serious complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT).	28934311
Chronic graft-versus-host disease	Stem Cell Exhaustion	Because all donors received the identical filgrastim dosing schedule, this study allowed for a controlled evaluation of the impact of stem cell source on development of chronic graft-versus-host disease.	28935847
Transplantation	Stem Cell Exhaustion	Nutritional Status of Hematological Patients before Hematopoietic Stem Cell Transplantation and in Early Posttransplantation Period.	28937794
Specialty Type - cancer	Stem Cell Exhaustion	Aldehyde dehydrogenase 1 (ALDH1) is associated with tumorigenesis, and shown to identify cancer stem cells (CSC)-like cells.	28939082
Adult Glioblastoma	Stem Cell Exhaustion	Purpose: CD90 (Thy-1) is a glycophosphatidylinositol-anchored glycoprotein considered as a surrogate marker for a variety of stem cells, including glioblastoma (GBM) stem cells (GSC).	28939749
Acute lymphocytic leukemia	Stem Cell Exhaustion	Survival after stem-cell transplant in pediatric and young-adult patients with relapsed and refractory B-cell acute lymphoblastic leukemia.	28945102
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	Allogeneic stem-cell transplant (allo-SCT) is the standard of care for pediatric patients with acute lymphoblastic leukemia (ALL) who relapse after frontline chemotherapy; however, for patients who relapse after allo-SCT, outcomes are very poor.	28945102
herpesvirus 3, human	Stem Cell Exhaustion	Herpes zoster incidence and cost in patients receiving autologous hematopoietic stem-cell transplant.	28945107
herpesvirus 3, human	Stem Cell Exhaustion	Among patients receiving autologous hematopoietic stem cell transplant (Auto-HSCT), this study estimated the incidence of herpes zoster (HZ), compared healthcare costs among patients with and without HZ, and evaluated antiviral prophylaxis (AP) use.	28945107
Specialty Type - cancer, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Cancer stem cells (CSCs) are a subpopulation of tumour cells capable of self-renewal and differentiation, likely responsible for the initiation, recurrence, metastasis and chemo/radio-resistance.	28946555
Decreased platelet count	Stem Cell Exhaustion	Impaired Function of Bone Marrow Mesenchymal Stem Cells from Immune Thrombocytopenia Patients in Inducing Regulatory Dendritic Cell Differentiation Through the Notch-1/Jagged-1 Signaling Pathway.	28946811
Hodgkin Disease	Stem Cell Exhaustion	Brentuximab vedotin in patients with relapsed or refractory Hodgkin lymphoma who are Ineligible for autologous stem cell transplant: A Germany and United Kingdom retrospective study.	28949403
Hodgkin Disease	Stem Cell Exhaustion	Brentuximab vedotin (BV) is an anti-CD30 antibody-drug conjugate licensed for the treatment of relapsed/refractory Hodgkin lymphoma (rrHL) following autologous stem cell transplant (ASCT) or at least two prior therapies when ASCT or multiagent chemotherapy is not an option.	28949403
Bacterial Infections	Stem Cell Exhaustion	Purpose Allogeneic hematopoietic cell transplant recipients undergo myelosuppressive chemotherapy to allow engraftment of stem cells and are at particularly high risk for bacterial infections and adverse outcomes.	28950805
Empyema, Pleural, Lymphoma, Nocardia farcinica	Stem Cell Exhaustion	An unusual case of pleural empyema related to Nocardia farcinica and Ureaplasma urealyticum, occurring after autologous haematopoietic stem cell transplantation in a 30-year-old patient with lymphoma, is reported.	28951103
Toxic effect	Stem Cell Exhaustion	Impact of Toxicity on Survival for Older Adult Patients after CD34+ Selected Allogeneic Hematopoietic Stem Cell Transplantation.	28951193
Graft-vs-Host Disease	Stem Cell Exhaustion	Ex vivo CD34+ selection before allogeneic hematopoietic stem cell transplantation (allo-HCT) reduces graft-versus-host disease without increasing relapse but usually requires myeloablative conditioning.	28951193
Malignant neoplasm of lung	Stem Cell Exhaustion	In the present study, we successfully generated lung cancer stem cell (CSC)-like cells by introducing a small set of transcription factors into a lung cancer cell line.	28951614
Malignant neoplasm of lung, Specialty Type - cancer	Stem Cell Exhaustion	Interleukin-6 blockade attenuates lung cancer tissue construction integrated by cancer stem cells.	28951614
Malignant neoplasm of lung	Stem Cell Exhaustion	In addition to properties that are conventionally referred to as CSC properties, the lung induced CSCs exhibited the ability to form lung cancer-like tissues in vitro with vascular cells and mesenchymal stem cells, which showed structures and immunohistological patterns that were similar to human lung cancer tissues.	28951614
Malignant neoplasm of lung	Stem Cell Exhaustion	We found that interleukin-6 (IL-6), which was expressed in the lung induced CSCs, facilitates the formation of lung cancer organoids via the conversion of mesenchymal stem cells into alpha-smooth muscle actin (aSMA)-positive cells.	28951614
Acute leukemia	Stem Cell Exhaustion	Patients admitted to the Haematology department during 7 months, and fulfilled inclusion criteria were divided into 4 groups: Group 1, patients with acute leukaemia; Group 2, patients after autologous stem cell transplantation (SCT); Group 3, patients after allogeneic SCT; and Group 4, patients given platelet transfusion prior to intervention.	28952164
Lymphoma	Stem Cell Exhaustion	Rituximab after Autologous Stem-Cell Transplantation in Mantle-Cell Lymphoma.	28953447
Neoplasms	Stem Cell Exhaustion	A First-in-Human Phase I Study of the Anticancer Stem Cell Agent Ipafricept (OMP-54F28), a Decoy Receptor for Wnt Ligands, in Patients with Advanced Solid Tumors.	28954784
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Purpose: Wnt signaling is implicated in tumor cell dedifferentiation and cancer stem cell function.	28954784
Chronic disease, Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0	Stem Cell Exhaustion	Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hematopoietic stem cell disorder that must be correctly diagnose because it is a chronic disease with a real impact on the quality of life and the survival of the patients.	28958970
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Clinical impact of colonization with multidrug-resistant organisms on outcome after allogeneic stem cell transplantation in patients with acute myeloid leukemia.	28960264
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment option for patients with acute myeloid leukemia (AML).	28960264
Fulfill, Adult Glioblastoma, Neoplasms	Stem Cell Exhaustion	In this study we investigated ALK, ROS1, and MET status in nine glioblastoma stem cell lines and tumors from which they arise.	28960893
Adult Glioblastoma	Stem Cell Exhaustion	Crizotinib targets in glioblastoma stem cells.	28960893
Adult Glioblastoma, Neoplasms	Stem Cell Exhaustion	Glioblastoma stem cells (GSCs) are believed to be involved in the mechanisms of tumor resistance, therapeutic failures, and recurrences after conventional glioblastoma therapy.	28960893
Hematologic Neoplasms	Stem Cell Exhaustion	Serum levels, safety and tolerability of new formulation SUBA-itraconazole prophylaxis in patients with haematological malignancy or undergoing allogeneic stem cell transplantation.	28961894
Hyalinosis, Systemic, Osteoporotic Fractures	Stem Cell Exhaustion	A unique heterologous fibrin sealant (HFS) as a candidate biological scaffold for mesenchymal stem cells in osteoporotic rats.	28962655
Osteoporotic Fractures	Stem Cell Exhaustion	The injection of mesenchymal stem cells (MSCs) directly into the bone of osteoporotic (OP) patients for rapid recovery has been studied worldwide.	28962655
Myeloid neoplasm	Stem Cell Exhaustion	Bone marrow mesenchymal stromal cells (MSCs), which support proliferation and differentiation of hematopoietic stem cells, may play a crucial role in the pathogenesis of myeloid neoplasms.	28964959
Thrombocytopenic purpura	Stem Cell Exhaustion	Effect of thrombopoietin receptor agonists on leukocyte and haematopoietic stem and progenitor cells in the peripheral blood of patients with immune thrombocytopenic purpura.	28965224
Primary Myelofibrosis, Leukocytosis	Stem Cell Exhaustion	Our results indicate that TPO-RAs may also mobilize haematopoietic stem and progenitor cells (HSPCs) in peripheral blood and the occurrence of such relative leukocytosis may signalize an early symptom of myelofibrosis due to treatment with TPO-RAs.	28965224
Lymphoma, Follicular	Stem Cell Exhaustion	Efficacy of idelalisib as bridge to allogeneic stem cell transplant in relapsed follicular lymphoma: a case report.	28967090
Lymphoma, Follicular	Stem Cell Exhaustion	We describe the case of a 39-year-old patient with a diagnosis of grade 3a FL and a Follicular Lymphoma International Prognostic Index score of 2, who underwent several lines of therapy (including autologous stem cell transplant) with transient responses or no response at all.	28967090
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	Are CD44+/CD24- cells the assumed cancer stem cells in breast cancer?	28967636
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Identification and characterization of the population of cancer stem cells (CSC) depends on several cellular markers, which combination is specific for the phenotype of CSC in the corresponding tumor.	28967636
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	To search for additional molecular-biological markers of cancer stem cell (CSC) involved in the development of intra-tumor heterogeneity for the detection of features of the breast cancer (BC) pathogenesis.	28967645
Malignant Neoplasms	Stem Cell Exhaustion	Cells of high-grade malignancy (HGM), MDA-MB-231 and MDA-MB-468 are characterized by high expression of stem cell markers compared to the cells of low-grade malignancy (LGM), T47D and MCF-7: CD44 levels in T47D and MCF-7 cells were in range of 72-79 points, which is significantly lower than in HGM cells (p < 0.05).	28967645
Bone Marrow Transplantation, Nodular Lymphocyte Predominant Hodgkin Lymphoma	Stem Cell Exhaustion	High dose chemotherapy and autologous stem cell transplantation in nodular lymphocyte-predominant Hodgkin lymphoma: A retrospective study by the European society for blood and marrow transplantation-lymphoma working party.	28971503
Hodgkin Disease, Nodular Lymphocyte Predominant Hodgkin Lymphoma	Stem Cell Exhaustion	Whilst autologous stem cell transplantation (auto-SCT) is considered standard of care for relapsed/refractory classical Hodgkin lymphoma, the role of auto-SCT in nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is not well defined due to limited data.	28971503
Leukemia, Myelocytic, Acute, Acute leukemia	Stem Cell Exhaustion	Relatively favorable outcome after allogeneic stem cell transplantation for BCR-ABL1-positive AML: A survey from the acute leukemia working party of the European Society for blood and marrow transplantation (EBMT).	28971504
Acute myeloid leukemia with BCR-ABL1, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The aim of the study was to assess the role of allogeneic stem cell transplantation (SCT) in patients diagnosed with BCR-ABL1-positive acute myeloid leukemia (AML).	28971504
Acute leukemia	Stem Cell Exhaustion	Mixed phenotype acute leukemia: outcomes with allogeneic stem cell transplantation.	28971902
leukemia, Acute leukemia	Stem Cell Exhaustion	In this study, we investigated 519 patients with mixed phenotype acute leukemia in first complete remission who underwent allogeneic hematopoietic stem cell transplantation between 2000 and 2014, and who were reported to the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT).	28971902
Acute leukemia	Stem Cell Exhaustion	Our study suggests that mixed phenotype acute leukemia is potentially sensitive to graft-versus-leukemia and thus can benefit from allogeneic hematopoietic stem cell transplantation with a potential for cure.	28971902
Toxic effect	Stem Cell Exhaustion	Nineteen CP patients, discontinued due to resistance (n = 13), toxicity (n = 5) and to pursue stem cell transplantation (n = 1).	28972430
Hyperplasia	Stem Cell Exhaustion	The aim of our study was to explore the age-related specificities of endometrial proliferative / stem cell index distribution under normal and hyperplasia conditions.	28972492
Endometrial Hyperplasia	Stem Cell Exhaustion	In the 2nd study group labeled as "endometrial hyperplasia", the proliferative/stem cell index markedly increases and ranges within the interval 15-23.	28972492
Endometrial Hyperplasia	Stem Cell Exhaustion	It was found that proliferative/stem cell index in the 1st study group labeled as "Norm" progressively decreases with aging, while in the 2nd study group labeled as "Endometrial Hyperplasia" it behaves opposite and increases with age.	28972492
Endometrial Hyperplasia	Stem Cell Exhaustion	Moreover, it must be noted that proliferative/stem cell index in endometrial hyperplasia cases with regard to norm increases significantly, namely in the subgroups 1.1/1.2 (which is reproductive age) it increases 1.5 times, and in the subgroups 1.2/2.2 (which is menopause age) it increases 2.5 times, while in the subgroups 1.3/2.3 (which is post-menopause age) it increases 18.5 times.	28972492
Endometrial Hyperplasia	Stem Cell Exhaustion	The high attention should be given to the fact that the mean average value of proliferative/stem cell index in endometrial hyperplasia most markedly differs from the norm in post-menopause period.	28972492
Acute lymphocytic leukemia	Stem Cell Exhaustion	The efficacy of conventional chemotherapy and allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been controversial as post-remission therapies for adult Philadelphia chromosome-negative acute lymphoblastic leukemia patients.	28973362
Vascular Diseases	Stem Cell Exhaustion	Lower levels of circulating progenitor cells (PCs) reflect impaired endogenous regenerative capacity and are associated with aging, vascular disease, and poor outcomes.	28974500
Heart failure, Heart Diseases	Stem Cell Exhaustion	Safety and Efficacy of the Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Patients With Heart Failure: A Phase 1/2 Randomized Controlled Trial (RIMECARD Trial [Randomized Clinical Trial of Intravenous Infusion Umbilical Cord Mesenchymal Stem Cells on Cardiopathy]).	28974553
Cardiovascular Diseases	Stem Cell Exhaustion	Umbilical cord-derived mesenchymal stem cells (UC-MSC) are easily accessible and expanded in vitro, possess distinct properties, and improve myocardial remodeling and function in experimental models of cardiovascular disease.	28974553
Heart failure	Stem Cell Exhaustion	Although bone marrow-derived mesenchymal stem cells have been previously assessed for their therapeutic potential in individuals with heart failure and reduced ejection fraction, no clinical trial has evaluated intravenous infusion of UC-MSCs in these patients.	28974553
Seizures, Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	A 61-year-old man with relapsing chronic lymphocytic leukaemia, status post allogeneic stem cell transplant and multiple chemotherapy regimens presented to the emergency room after suffering a grand mal seizure.	28978601
Heart failure	Stem Cell Exhaustion	Autologous cardiac progenitor cell (CPC) therapy is a promising approach for treatment of heart failure (HF).	28980705
Heart failure	Stem Cell Exhaustion	Autologous cardiac progenitor cell therapy is a promising alternative approach to current inefficient therapies for heart failure (HF).	28980705
Epstein-Barr virus	Stem Cell Exhaustion	NK/T-LAHS patients who underwent allogeneic hematopoietic stem cell transplantation (Allo-HSCT) (p = 0.000), exhibited peripheral blood Epstein-Barr virus (EBV)-positivity (p = 0.004), and achieved overall response (OR) remission after initial induction therapy (p = 0.007) had statistical significance.	28982299
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	Association Between Endothelial Progenitor Cells and Treatment Response in Non-Squamous Non-small Cell Lung Cancer Treated with Bevacizumab.	28982871
Non-Small Cell Lung Carcinoma	Stem Cell Exhaustion	To investigate the association between the number of circulating endothelial progenitor cells (EPCs) in non-squamous non-small cell lung cancer (NSCLC) and disease outcome, in combination chemotherapy with and without bevacizumab.	28982871
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Cancer stem cells (CSC) plays an important role in various kinds of cancers.	28982889
Acute lymphocytic leukemia, BCR gene	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HSCT) with the conventional cyclophosphamide and total body irradiation (CY/TBI) regimen is an essential therapeutic strategy for acute lymphoblastic leukemia (ALL) in adults.	28983949
Hepatic Veno-Occlusive Disease, Lung Injury	Stem Cell Exhaustion	Hepatic Sinusoidal-obstruction Syndrome and Busulfan-induced Lung Injury in a Post-autologous Stem Cell Transplant Recipient.	28984258
Central neuroblastoma	Stem Cell Exhaustion	We illustrate the clinical and autopsy finings in a 2 1/2 -year-old boy who received autologous stem-cell transplantation following resection of stage IV neuroblastoma.	28984258
Esophageal carcinoma, Concomitant Medication Submission Domain	Stem Cell Exhaustion	We analyzed: (i) the peritumoral adipose tissue of rats following the induction of esophageal carcinogenesis; (ii) the peritumoral and distal (omental) adipose tissue of patients affected by EAC; (iii) adipose-derived stem cells (ADSC) isolated from healthy patients and treated with conditioned medium (CM), collected from tumoral and adipose tissue of patients with EAC.	28985034
Kidney Failure, Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Autologous stem cell transplantation (ASCT) reverses kidney failure in one-third of multiple myeloma (MM) patients, which may lead to blood pressure (BP) improvement.	28987247
Multiple Myeloma	Stem Cell Exhaustion	Before the introduction of "new drugs," we designed a trial in which 162 newly diagnosed myeloma patients were biologically randomized to receive either an autologous stem cell transplant (auto-SCT) followed by a nonmyeloablative allogeneic stem cell transplant (allo-SCT) or a double auto-SCT.	28987930
Aplastic Anemia	Stem Cell Exhaustion	Fludarabine-based reduced intensity regimen for matched related donor hematopoietic stem cell transplantation in acquired severe aplastic anemia.	28988743
Aplastic Anemia	Stem Cell Exhaustion	Different conditioning regimens have been evaluated in matched-related donor allogeneic hematopoietic stem cell transplantation (allo-HSCT) for acquired severe aplastic anemia (SAA) with varying results.	28988743
Specialty Type - cancer, Endometrial Endometrioid Adenocarcinoma	Stem Cell Exhaustion	Association between Morphological Patterns of Myometrial Invasion and Cancer Stem Cell Markers in Endometrial Endometrioid Carcinoma.	28990139
Specialty Type - cancer	Stem Cell Exhaustion	The present study investigated the association between MI patterns, cancer stem cell (CSC) phenotypes, and their clinicopathological significance in EEC.	28990139
Bacteremia	Stem Cell Exhaustion	Incidence, Risk Factors and Outcome of Pre-engraftment Gram-Negative Bacteremia After Allogeneic and Autologous Hematopoietic Stem Cell Transplantation: An Italian Prospective Multicenter Survey.	29020286
Bacteremia, Cessation of life	Stem Cell Exhaustion	Gram-negative bacteremia (GNB) is a major cause of illness and death after hematopoietic stem cell transplantation (HSCT), and updated epidemiological investigation is advisable.	29020286
Bacteremia	Stem Cell Exhaustion	Antimicrobial Resistance in Gram-Negative Rods Causing Bacteremia in Hematopoietic Stem Cell Transplant Recipients: Intercontinental Prospective Study of the Infectious Diseases Working Party of the European Bone Marrow Transplantation Group.	29020364
Specialty Type - cancer	Stem Cell Exhaustion	The meeting covered a plethora of rapidly evolving approaches and areas, such as organoid cultures modeling tissues and organs; stem cell-specific metabolites revealing new signaling pathways; single-cell technologies discovering new cell types and exploring stem cell niche interactions; novel methods studying stem cells in aging and cancer; lineage-tracing experiments exploring cell plasticity of tissues before and after injury; epigenetic studies illuminating cell reprogramming; new protocols improving cells for regenerative purposes; and several other timely and exciting topics.	29020612
Antilymphocyte Serum	Stem Cell Exhaustion	We generated and characterized induced pluripotent stem cells (iPSCs) from ALS patients with different FUS mutations, as well as from healthy controls.	29021520
Antilymphocyte Serum	Stem Cell Exhaustion	Using motor neurons derived from induced pluripotent stem cells from patients with ALS and FUS mutations, the authors demonstrate that axonal transport deficits that are observed in these cells can be rescued by HDAC6 inhibition.	29021520
Toxic effect	Stem Cell Exhaustion	Additionally, TAUP301L neither increased neural stem cell proliferation nor activated the expression of regenerative factor Interleukin-4, indicating that TAUP301L toxicity is prevented in the adult zebrafish brain.	29021554
Lipoma	Stem Cell Exhaustion	Comparison of clinical variables, histologic analyses and characterization of the lipoma adipose-derived stem cells (ASCs) between the two lipomas were performed.	29022421
Cerebrovascular accident	Stem Cell Exhaustion	Regenerative medicine: Stroke survivor and carer views and motivations towards a proposed stem cell clinical trial using placebo neurosurgery.	29024214
Cerebrovascular accident	Stem Cell Exhaustion	Few studies explore stroke survivor views and motivations towards stem cell therapy (SCT).	29024214
Cerebrovascular accident	Stem Cell Exhaustion	This qualitative study explores the views and motivations of both stroke survivors and their partners/carers towards a proposed 2-arm Phase III Randomised Controlled Trial (RCT) comparing intracerebral insertion of stem cells with placebo neurosurgery in stroke survivors with disability.	29024214
Ischemia	Stem Cell Exhaustion	Adipose-derived mesenchymal stem cells (ASCs) have been shown to produce vascular endothelial growth factor (VEGF) and can increase perfusion in patients with critical limb ischemia.	29025216
Myeloid Cell Differentiation, Neoplasms	Stem Cell Exhaustion	Neoplasms characterized by this fusion are pluripotent stem cell disorders that can show both myeloid and lymphoid differentiation.	29025601
ibudilast	Stem Cell Exhaustion	Stem cell therapy is promising, but little is known about the differences in adipose-derived stem cells (ADSCs) between IBD patients and healthy individuals.	29027585
Inflammatory Bowel Diseases	Stem Cell Exhaustion	The features of adipose-derived stem cells in patients with inflammatory bowel diseases.	29027585
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease (aGVHD) is a major complication of allogeneic haematopoietic stem cell transplantation (HSCT).	29027756
Metaplastic carcinoma of breast	Stem Cell Exhaustion	Nestin and CD146 expression in metaplastic breast cancer: stem-cell therapy in need?	29028085
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	In the tissue sample stem cell markers, nestin and CD146 (MCAM) were expressed, enhancing the theory that cancer cells of this tumor could possibly harbor stem cell properties.	29028085
Metaplastic carcinoma of breast	Stem Cell Exhaustion	Metaplastic breast cancer consists of cells with stem cell properties.	29028085
Liver carcinoma, Neoplasms, Specialty Type - cancer, Chromosome Aberrations	Stem Cell Exhaustion	Quantified postsurgical small cell size CTCs and EpCAM+ circulating tumor stem cells with cytogenetic abnormalities in hepatocellular carcinoma patients determine cancer relapse.	29031565
Neoplasms	Stem Cell Exhaustion	The stemness marker EpCAM+ aneuploid circulating tumor stem cells (CTSCs), and EpCAM- small CTCs with trisomy 8, promote tumor growth.	29031565
Aplastic Anemia	Stem Cell Exhaustion	Effect of Antithymocyte Globulin Source on Outcomes of HLA-Matched Sibling Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Severe Aplastic Anemia.	29032265
Aplastic Anemia	Stem Cell Exhaustion	We wanted to evaluate efficacy of porcine antithymocyte globulin (ATG) in HLA-matched sibling donor allogeneic hematopoietic stem cell transplantation (MSD-HSCT) for patients with severe aplastic anemia (SAA).	29032265
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	We report the long-term clinical outcomes of a retrospective multicenter study that enrolled 169 patients with multiple myeloma (MM) in first relapse after failing autologous stem cell transplantation (SCT).	29032267
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Assessment of Impact of HLA Type on Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia.	29032274
Refractory Disease	Stem Cell Exhaustion	Chemorefractory disease, often characterized by deletion of chromosome 17p, has historically been associated with very poor outcomes, leading to the application of allogeneic hematopoietic stem cell transplantation (allo-HCT) for medically fit patients.	29032274
Lymphoma	Stem Cell Exhaustion	Treatment of patients with relapsed or refractory lymphoma may require allogenic hematopoietic stem cell transplant (HSCT), but treatment of post-transplant relapse disease remains very challenging.	29032736
Charcot-Marie-Tooth Disease	Stem Cell Exhaustion	Generation of induced pluripotent stem cell (iPSC) line from Charcot-Marie-Tooth disease patient with MPZ mutation (CMT1B).	29034895
Memory	Stem Cell Exhaustion	Recently identified T memory stem (Tscm) cells have stem-cell-like properties, including long lifespan, self-renewal capacity, and multipotency to differentiate into other memory T cell types.	29035156
Degenerative polyarthritis	Stem Cell Exhaustion	Mixed cell therapy of bone marrow-derived mesenchymal stem cells and articular cartilage chondrocytes ameliorates osteoarthritis development.	29035380
Degenerative polyarthritis	Stem Cell Exhaustion	Here we report of a series of experiments in which bone marrow-derived stem cells (BMSCs) and articular cartilage chondrocytes (ACCs) were mixed in a 1:1 ratio and tested for their ability to enhance cartilage regeneration in three different conditions: (1) in an in vitro differentiation model; (2) in an ex vivo cartilage defect model implanted subcutaneously in mice; and (3) as an intra-articular injection in a meniscectomy-induced OA model in rats.	29035380
Thalassemia	Stem Cell Exhaustion	Long-term outcome of mixed chimerism after stem cell transplantation for thalassemia major conditioned with busulfan and cyclophosphamide.	29035392
Thalassemia	Stem Cell Exhaustion	Mixed chimerism (MC) occurs frequently after allogeneic hematopoietic stem cell transplantation (HSCT) for thalassemia major (TM) and may be associated with rejection.	29035392
B-Cell Lymphomas	Stem Cell Exhaustion	Replacing carmustine by thiotepa and cyclophosphamide for autologous stem cell transplantation in Hodgkin's and non-Hodgkin's B-cell lymphoma.	29035395
Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	The infusion of autograft absolute lymphocyte count (A-ALC) and autograft natural killer cells (A-NKC) are prognostic factors for overall survival (OS) and PFS in non-Hodgkin's lymphoma (NHL) patients undergoing autologous peripheral blood hematopoietic stem cell transplantation (APBHSCT).	29035394
Multiple Myeloma	Stem Cell Exhaustion	Novel induction agents markedly improved remission rates in multiple myeloma (MM), and the continued use of chemotherapy for CD34+ stem cell mobilization (SCM) has been questioned.	29037891
Coma, Post-Head Injury	Stem Cell Exhaustion	Effect of autologous adipose-derived mesenchymal stem cell therapy in the treatment of a post-traumatic chondral defect of the knee.	29038190
Failure	Stem Cell Exhaustion	After failure to symptomatically improve 12 months following surgery, the patient received intra-articular autologous adipose-derived mesenchymal stem cell (ADMSC) therapy.	29038190
Kidney Failure, Acute	Stem Cell Exhaustion	Allogeneic Mesenchymal Stem Cells for Treatment of AKI after Cardiac Surgery.	29038286
Kidney Failure, Acute	Stem Cell Exhaustion	We conducted a phase 2, randomized, double-blind, placebo-controlled trial in 27 centers across North America to determine the safety and efficacy of allogeneic human mesenchymal stem cells (MSCs) in reducing the time to recovery from AKI after cardiac surgery.	29038286
Endometrial disorder, Endometriosis, Endometriosis of uterus	Stem Cell Exhaustion	Using N-cadherin as a marker, the molecular and cellular characteristics of epithelial progenitor cells and their role in endometrial proliferative disorders including endometriosis, adenomyosis and thin dysfunctional endometrium can be investigated.	29040564
Protein Deficiency	Stem Cell Exhaustion	Furthermore, both in PC12 neuronal cells and in patients' induced pluripotent stem cell-derived midbrain neurons, we observed that parkin deficiencies cause the fragmentation of stable MTs.	29040870
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Consolidation therapy with decitabine and intermediate-dose cytarabine followed by HLA-mismatched peripheral blood stem cells infusion for older patients with acute myeloid leukemia in first remission.	29043875
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	This retrospective study tested the feasibility of decitabine (DAC) plus intermediate-dose cytarabine (ID-AraC) followed by HLA-mismatched granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral donor blood stem cells (GPBSCs) infusion as consolidation treatment for older patients with acute myeloid leukemia (AML) in first complete remission (CR).	29043875
Retinal Detachment	Stem Cell Exhaustion	Induction of focal retinal detachment (RD) for subretinal delivery of stem cells and gene therapy is increasingly common.	29049728
Specialty Type - cancer, Refractory Cytopenia of Childhood	Stem Cell Exhaustion	The aim of this study was to investigate the expression patterns and prognostic significance of the cancer stem cell marker CD133 in different histological subtypes of RCC.	29050853
Specialty Type - cancer	Stem Cell Exhaustion	Prominin-1 (CD133) is one of the most commonly used markers for cancer stem cells (CSCs), which are characterized by their ability for self-renewal and tumorigenicity.	29050853
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Impact of Allogeneic Stem Cell Transplantation in First Complete Remission in Acute Myeloid Leukemia: A National Population-Based Cohort Study.	29051022
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	To examine the outcomes of allogeneic stem cell transplantation (HSCT) in first complete remission (CR1) compared with chemotherapy alone in a population-based setting, we identified a cohort of patients with acute myeloid leukemia (AML) aged 15 to 70 years diagnosed between 2000 and 2014 in Denmark.	29051022
Hepatotoxicity	Stem Cell Exhaustion	Busulfan-Dependent Hepatotoxicity of Antithymocyte Globulin Formulations During Conditioning for Hematopoietic Stem Cell Transplantation.	29051024
Cessation of life, Bone marrow hypocellularity	Stem Cell Exhaustion	In competing risk analyses the cumulative incidence of severe bone marrow failure, leading to stem cell transplantation or death, was more than 70% by age 60.	29051281
Dyskeratosis Congenita, Neoplasms, Fanconi Anemia	Stem Cell Exhaustion	The risk of solid tumors following stem cell transplantation in Fanconi anemia and in dyskeratosis congenita was significantly higher than in non-transplanted patients.	29051281
Primary central nervous system lymphoma, extranodal lymphoma	Stem Cell Exhaustion	Whole-brain radiotherapy or autologous stem-cell transplantation as consolidation strategies after high-dose methotrexate-based chemoimmunotherapy in patients with primary CNS lymphoma: results of the second randomisation of the International Extranodal Lymphoma Study Group-32 phase 2 trial.	29054815
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Long-term survival of sorafenib-treated FLT3-ITD-positive acute myeloid leukaemia patients relapsing after allogeneic stem cell transplantation.	29055209
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD)-positive acute myeloid leukaemia (AML) relapsing after allogeneic stem cell transplantation (allo-SCT) has a dismal prognosis with limited therapeutic options.	29055209
Polycystic Kidney, Autosomal Dominant	Stem Cell Exhaustion	Generation of an induced pluripotent stem cell line, IBMS-iPSC-014-05, from a female autosomal dominant polycystic kidney disease patient carrying a common mutation of R803X in PKD2.	29055226
Polycystic Kidney, Autosomal Dominant	Stem Cell Exhaustion	Here we generated an induced pluripotent stem cell (iPSC) line from the peripheral blood mononuclear cells (PBMCs) of a 63-year-old female ADPKD patient carrying an R803X mutation in the PKD2 gene using the Sendai-virus delivery system.	29055226
Sample Size Calculation	Stem Cell Exhaustion	Adipose-derived mesenchymal stem cells (AD-MSCs) and PRPs were purified from healthy donors and SSc patients.	29058626
Multiple Myeloma	Stem Cell Exhaustion	NSAID treatment with meloxicam enhances peripheral stem cell mobilization in myeloma.	29058701
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Chemotherapy with G-CSF is used to mobilize peripheral stem cells in multiple myeloma (MM) patients, with plerixafor as a rescue strategy for poorly mobilizing patients.	29058701
Graft-vs-Host Disease	Stem Cell Exhaustion	Blocking lymphocyte trafficking after allogeneic hematopoietic stem cell transplantation is a promising strategy to prevent graft-versus-host disease (GVHD) while preserving the graft-versus-tumor response.	29061535
Mantle cell lymphoma	Stem Cell Exhaustion	Total Body Irradiation Is Safe and Similarly Effective as Chemotherapy-Only Conditioning in Autologous Stem Cell Transplantation for Mantle Cell Lymphoma.	29061536
Medial collateral ligament, Mantle cell lymphoma	Stem Cell Exhaustion	Autologous stem cell transplant (ASCT) consolidation has become a standard approach for patients with mantle cell lymphoma (MCL), yet there is little consensus on the role of total body irradiation (TBI) as part of high-dose transplantation conditioning.	29061536
Multiple Myeloma	Stem Cell Exhaustion	Novel agent-based salvage autologous stem cell transplantation for relapsed multiple myeloma.	29063955
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is a standard frontline therapy for multiple myeloma (MM).	29063955
Tuberculosis	Stem Cell Exhaustion	Incidence and clinical profile of tuberculosis after allogeneic stem cell transplantation.	29064140
Tuberculosis	Stem Cell Exhaustion	Patients post allogeneic stem cell transplantation (alloSCT) are expected to be at high risk of tuberculosis (TB) owing to underlying immunosuppression.	29064140
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	The aim of this study was to identify the percentage of CD34+CD38-CD123+ cells in AML blasts, AML CD34+CD38- stem cells, and normal and regenerating bone marrow CD34+CD38- stem cells from non-myeloid malignancies.	29065396
Multiple Myeloma	Stem Cell Exhaustion	A phase 1 trial of autologous stem cell transplantation conditioned with melphalan 200 mg/m2 and total marrow irradiation (TMI) in patients with relapsed/refractory multiple myeloma.	29065747
Multiple Myeloma	Stem Cell Exhaustion	In this phase 1 study, we tested increasing doses of total marrow irradiation (TMI) in addition to standard intravenous melphalan at 200 mg/m2 (Mel200) in the conditioning regimen prior to autologous stem cell transplant (ASCT) for multiple myeloma (NCT02043847).	29065747
Osteoporosis	Stem Cell Exhaustion	STRA6 as a possible candidate gene for pathogenesis of osteoporosis from RNA-seq analysis of human mesenchymal stem cells.	29067460
Osteopenia, Osteoporosis	Stem Cell Exhaustion	To identify novel candidate genes associated with osteoporosis, RNA-sequence analysis of human mesenchymal stem cells (hMSCs) from patients with osteoporosis (G3) and osteopenia (G2), and healthy controls (G1) was performed.	29067460
Glioblastoma Multiforme Pathway, Adult Glioblastoma	Stem Cell Exhaustion	Glucocorticoids promote a glioma stem cell-like phenotype and resistance to chemotherapy in human glioblastoma primary cells: Biological and prognostic significance.	29067692
Glioblastoma Multiforme Pathway, Adult Glioblastoma, Neoplasms	Stem Cell Exhaustion	Glioma stem cells (GSCs) are glioblastoma (GBM) cells that are resistant to therapy and can give rise to recurrent tumors.	29067692
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease (aGVHD) is an important complication of allogeneic stem cell transplantation (alloSCT).	29073260
senile	Stem Cell Exhaustion	Firstly, differences in proliferative capacity of adipocyte or adipogenic differentiation in mouse mesenchymal stem cells (MMSCs) and senile mouse model-derived bone marrow mesenchymal stem cells (SMMSCs), as well as mRNA expression of OGN and PPARg2 were observed.	29073887
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease (aGVHD) remains a cause of excessive morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT).	29074374
MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic haematopoietic stem-cell transplantation remains the only curative treatment for relapsed/refractory acute myeloid leukaemia (AML) and high-risk myelodysplasia but has previously been limited to patients who achieve remission before transplant.	29076145
Hemolysis (biological function)	Stem Cell Exhaustion	All eight (100%) hematopoietic stem cell and 52 (95%) organ transplants were associated with hemolysis.	29076164
Hemolysis (biological function)	Stem Cell Exhaustion	Antibody screens detected five cases of hematopoietic stem cell PLS before hemolysis was apparent and two cases of organ PLS with antibodies without hemolysis.	29076164
Lymphoma, Follicular	Stem Cell Exhaustion	Overall survival (OS) is the gold-standard end point for studies evaluating autologous stem cell transplantation (ASCT) in follicular lymphoma (FL), but assessment may be elusive due to the lengthy disease course.	29076254
Lymphoma, Relapsing course	Stem Cell Exhaustion	Consolidative Radiotherapy After Autologous Stem Cell Transplantation for Relapsed or Refractory Diffuse Large B-cell Lymphoma.	29079283
Diffuse Large B-Cell Lymphoma	Stem Cell Exhaustion	We evaluated the role of consolidative radiotherapy (RT) for patients undergoing high-dose chemotherapy (HDC) and autologous stem cell transplantation (ASCT) for relapsed or refractory diffuse large B-cell lymphoma (DLBCL).	29079283
Vascular System Injuries	Stem Cell Exhaustion	We characterized vascular injury and functional recovery to understand the role of circulating endothelial progenitor cells in vascular repair.	29080864
Rheumatism	Stem Cell Exhaustion	Mesenchymal stem cells, that develop into joint tissues, show immunosuppressive and anti-inflammatory qualities, in vitro and in vivo, indicating a potential role for tissue engineering approaches in the treatment of rheumatic diseases.	29083361
PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	The purpose of this study was to evaluate the strategy of haploidentical (HID) stem cell combined with a small doses of umbilical cord blood (UCB) from a third-party donor transplantation (haplo-cord transplant) for treatment of myelodysplastic syndromes (MDS), by comparing with identical-sibling donor (ISD) transplantation.	29084206
Graft-vs-Host Disease, Hematologic Neoplasms	Stem Cell Exhaustion	A total of 157 patients receiving posaconazole tablet for prophylaxis during induction therapy for haematological malignancies and allogeneic stem cell transplant recipients with graft-versus-host disease were included for analysis.	29091205
Chronic cerebrovascular accident	Stem Cell Exhaustion	In this study, we investigated whether serum a2MG levels, endothelial function, and endothelial progenitor cell (EPC) number were associated in patients with chronic stroke or cardiovascular risk factors.	29093276
Rupture, Coma, Post-Head Injury, Amyloidosis	Stem Cell Exhaustion	Atraumatic Splenic Rupture Due to Ectopic Extramedullary Hematopoiesis after Autologous Stem Cell Transplantation in a Patient with AL Amyloidosis.	29093392
Splenic Rupture	Stem Cell Exhaustion	Splenic rupture was complicated during autologous stem cell transplantation (auto-SCT).	29093392
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	High prognostic value of pre-allogeneic stem cell transplantation minimal residual disease detection by WT1 gene expression in AML transplanted in cytologic complete remission.	29096332
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We analyzed the outcome of allogeneic stem cell transplantation (allo-SCT) in acute myeloid leukemia (AML) patients according to molecular Minimal Residual Disease (MRD) status prior to allo-SCT.	29096332
Inflammation	Stem Cell Exhaustion	We propose that suppression of inflammation through manipulation of Panx1 activity can stimulate epithelial cell progenitor (EPCP) engraftment.	29098296
Parkinson Disease	Stem Cell Exhaustion	Human Trials of Stem Cell-Derived Dopamine Neurons for Parkinson's Disease: Dawn of a New Era.	29100010
Parkinson Disease	Stem Cell Exhaustion	Stem cell-based therapies for Parkinson's disease are moving into a new and exciting era, with several groups pursuing clinical trials with pluripotent stem cell (PSC)-derived dopamine neurons.	29100010
Secondary Acute Myeloid Leukemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Outcome after relapse of myelodysplastic syndrome and secondary acute myeloid leukemia following allogeneic stem cell transplantation: a retrospective registry analysis on 698 patients by the Chronic Malignancies Working Party of the European Society of Blood and Marrow Transplantation.	29101205
Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	No standard exists for the treatment of myelodysplastic syndrome relapsing after allogeneic stem cell transplantation.	29101205
Malignant tumor of colon	Stem Cell Exhaustion	Immunohistochemistry was used to assess the expression of putative stem cell markers (ALDH1, CD44v6, CD133, Lgr5, SOX2) and immune cell related markers (CD3, CD8, FoxP3, PD-L1) in 104 patients with stage III colon cancer.	29102042
Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	DICER1 gene and miRNA dysregulation in mesenchymal stem cells of patients with myelodysplastic syndrome and acute myeloblastic leukemia.	29102598
Infection	Stem Cell Exhaustion	Poor Adherence Is Associated with More Infections after Pediatric Hematopoietic Stem Cell Transplant.	29102720
Injury of kidney	Stem Cell Exhaustion	Mesenchymal Stem Cells Contribute to Improvement of Renal Function in a Canine Kidney Injury Model.	29102933
Kidney Failure, Acute	Stem Cell Exhaustion	In the present study, mesenchymal stem cells derived from canine umbilical cord blood (cUCB-MSCs) were isolated and evaluated for their ability to improve renal function in a canine model of acute kidney injury (AKI).	29102933
Prostate carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Cancer Stem Cell Gene Variants Predict Disease Recurrence in Patients Treated with Radical Prostatectomy for Prostate Cancer.	29104488
Specialty Type - cancer, Neoplasms	Stem Cell Exhaustion	Background: Cancer stem cells (CSCs) are involved in tumor progression and drug resistance.	29104488
Endometrial Neoplasms	Stem Cell Exhaustion	To report a series of 11 ovarian and one endometrial neoplasm in elderly patients with mixed clear cell tumour and germ cell tumour (GCT) components, to compare their immunohistochemical profiles and demonstrate a putative stem cell population.	29106744
Embryonal Carcinoma	Stem Cell Exhaustion	However, there may also be undifferentiated stem cell areas with embryoid bodies, of the type seen in postpubertal testicular GCT, but lacking a complete embryonal carcinoma immunophenotype.	29106744
Adenocarcinoma, Clear Cell, Neoplasms	Stem Cell Exhaustion	Germ cell tumour growth patterns originating from clear cell carcinomas of the ovary and endometrium: a comparative immunohistochemical study favouring their origin from somatic stem cells.	29106744
Somatic	Stem Cell Exhaustion	We propose that OCT4-expressing somatic cancer cells differentiate into GCT and represent spontaneously induced pluripotent stem cells, possibly conditioned by age-related epigenetic factors.	29106744
Lichen disease	Stem Cell Exhaustion	Epithelial-to-Mesenchymal Stem Cell Transition in a Human Organ: Lessons from Lichen Planopilaris.	29106928
Alopecia, Lichen disease	Stem Cell Exhaustion	Here, we show that EMT also occurs within the bulge, the epithelial stem cell (eSC) niche of human scalp hair follicles, during the inflammatory permanent alopecia, lichen planopilaris.	29106928
Microcephaly	Stem Cell Exhaustion	ZIKV has been shown to infect neuronal progenitor cells of the fetal mouse brain, which is comparable to the first-trimester human fetal brain, and result in microcephaly.	29107512
Bone Marrow	Stem Cell Exhaustion	Univariate Cox model analysis showed that increased age, high white blood cell count, t (8;21) cytogenetic group, and high bone marrow blast percentage were associated with poor overall outcome, while stem cell transplant intervention was associated with better survival.	29107583
Cessation of life	Stem Cell Exhaustion	Multivariate Cox model analysis showed that t(8;21) cytogenetic group has more hazard of death after adjusting, age, marrow blast percentage, blood cell count, and stem cell transplant(hazard ratio 1.802; P = .02).	29107583
Malignant tumor of colon	Stem Cell Exhaustion	Using the stem cell markers CD133, CD166 and CD44, we found a subpopulation of highly tumorigenic human colon cancer cells.	29110645
Malignant tumor of colon	Stem Cell Exhaustion	Long intergenic non-protein-coding RNA 1567 (LINC01567) acts as a "sponge" against microRNA-93 in regulating the proliferation and tumorigenesis of human colon cancer stem cells.	29110645
Specialty Type - cancer, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Cancer stem cells (CSCs) are considered to be the major factor in tumor initiation, progression, metastasis, recurrence and chemoresistance.	29110645
Pneumocystis jiroveci pneumonia, Superinfection, Coinfection	Stem Cell Exhaustion	Influenza and Pneumocystis jirovecii pneumonia in an allogeneic hematopoietic stem cell transplantation recipient: Coinfection or superinfection?	29111605
Pneumocystis jiroveci pneumonia, Influenza, Infection	Stem Cell Exhaustion	Influenza infection and Pneumocystis jirovecii pneumonia (PJP) in hematopoietic stem cell transplant (HSCT) patients are well characterized; however, no dual infections have been reported in this patient population and little evidence of mechanisms of interaction between the two infections exists.	29111605
atherosclerotic, Coronary Arteriosclerosis	Stem Cell Exhaustion	Adipose-tissue derived mesenchymal stem cell (ADSC)-based therapy is a promising option for patients with atherosclerotic conditions, including coronary artery disease.	29115374
Temporomandibular Joint	Stem Cell Exhaustion	Synovial fluid-derived synovial fragments represent an improved source of synovial mesenchymal stem cells in the temporomandibular joint.	29115378
Dissection of aorta	Stem Cell Exhaustion	Transcriptome sequencing revealed candidate genes relevant to mesenchymal stem cells' role in aortic dissection patients.	29115411
Up	Stem Cell Exhaustion	Mesenchymal stem cells (MSCs) are known for anti-inflammatory and repairing effects and have therefore been studied for treatment for numerous diseases, including AD.	29115411
Fibrosis Assessment, Dilated Cardiomyopathy Pathway, Cardiac dysfunction	Stem Cell Exhaustion	Human umbilical cord mesenchymal stem cells alleviate interstitial fibrosis and cardiac dysfunction in a dilated cardiomyopathy rat model by inhibiting TNF-a and TGF-b1/ERK1/2 signaling pathways.	29115435
Doctor of Chiropractic	Stem Cell Exhaustion	In the present study, the beneficial role of human umbilical cord-derived mesenchymal stem cells (HuMSCs) derived from Wharton's jelly was evaluated in the myosin-induced rat model of DCM.	29115435
Pancytopenia, Bone marrow hypocellularity, Aplastic Anemia, primary disorders	Stem Cell Exhaustion	Severe aplastic anemia (SAA) is a primary disorder of severe bone marrow failure characterizing with extreme pancytopenia and a profound diminution of bone marrow progenitor cells, which is associated with T cell hyper-function.	29115638
Polycystic Kidney, Autosomal Dominant	Stem Cell Exhaustion	Induced pluripotent stem cells derived from an autosomal dominant polycystic kidney disease patient carrying a PKD1 Q533X mutation.	29121521
Kidney Failure, Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	We generated induced pluripotent stem cells (iPSCs) from a 37-year-old man carrying a PKD1 Q533X mutation who suffered from kidney failure and a myocardial infarction.	29121521
Liver carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	SOX9 is a proliferation and stem cell factor in hepatocellular carcinoma and possess widespread prognostic significance in different cancer types.	29121666
Specialty Type - cancer, Childhood Breast Carcinoma	Stem Cell Exhaustion	Functional SOX9 knock-down studies using siRNA and cancer stem cell models were generated in a panel of liver and breast cancer cell lines.	29121666
Chronic disease, Usual Severity Pain	Stem Cell Exhaustion	The effect of pre-transplant pain and chronic disease self-efficacy on quality of life domains in the year following hematopoietic stem cell transplantation.	29124418
Usual Severity Pain	Stem Cell Exhaustion	Pain is common for hematopoietic stem cell transplant (HSCT) patients and may be experienced pre-transplant, acutely post-transplant, and for months or years following transplant.	29124418
Specialty Type - cancer	Stem Cell Exhaustion	YKL-40 (also known as Chitinase 3-like 1) is a glycoprotein produced by inflammatory, cancer and stem cells.	29126445
Glioblastoma	Stem Cell Exhaustion	In the other two, adults with glioblastoma multiforme received neural progenitor cell sparing radiation or no sparing with extra dose delivered to subventricular zone.	29128167
Chronic Lymphocytic Leukemia, Lymphoma	Stem Cell Exhaustion	Combined Haploidentical and Umbilical Cord Blood Allogeneic Stem Cell Transplantation for High-Risk Lymphoma and Chronic Lymphoblastic Leukemia.	29128555
Malignant Neoplasms	Stem Cell Exhaustion	Limited studies have reported on outcomes for lymphoid malignancy patients receiving alternative donor allogeneic stem cell transplants.	29128555
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	We analyzed 42 lymphoma and chronic lymphoblastic leukemia (CLL) patients who underwent haplo-cord allogeneic stem cell transplantation.	29128555
Dystonia 3, Torsion, X-Linked	Stem Cell Exhaustion	Generation of induced pluripotent stem cell line (ZZUi005-A) from a 21-year-old patient with a novel RAB39B gene mutation in X-linked juvenile parkinsonism.	29128816
Dystonia 3, Torsion, X-Linked	Stem Cell Exhaustion	Recently, a novel RAB39B mutation was identified in an X-linked juvenile parkinsonism family and the dermal fibroblasts of the patient were obtained and successfully induced to induced pluripotent stem cells (iPSCs) by the human OSKM transcription factors using the Sendai-virus delivery system.	29128816
Adrenoleukodystrophy	Stem Cell Exhaustion	Generation of induced pluripotent stem cell (iPSC) line from a 21-year-old X-linked adrenoleukodystrophy (X-ALD) patient.	29128817
Adrenoleukodystrophy	Stem Cell Exhaustion	We generated an induced pluripotent stem cell (iPSC) line from a 21-year-old male X-ALD patient-derived fibroblasts by Sendai virus mediated reprogramming.	29128817
Liver carcinoma, Primary Malignant Liver Neoplasm, Intrahepatic Cholangiocarcinoma, Hollings Cancer Center	Stem Cell Exhaustion	Recent animal studies indicate that disruption of NF2/Merlin function in oval cells, which are hepatic progenitor cells, may lead to the development of primary liver cancers including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC); however, its role in human primary liver cancer remains unclear.	29130106
Specialty Type - cancer	Stem Cell Exhaustion	Spheroid colony formation is a useful method of cancer stem cell (CSC) characterization.	29131081
neurological complication	Stem Cell Exhaustion	Neurologic complications after allogeneic hematopoietic stem cell transplantation: risk factors and impact.	29131150
Multiple Myeloma	Stem Cell Exhaustion	Elevated pre-transplant C-reactive protein identifies a high-risk subgroup in multiple myeloma patients undergoing delayed autologous stem cell transplantation.	29131152
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The significance of elevated C-reactive protein (CRP) prior to autologous stem cell transplantation (ASCT) in multiple myeloma (MM) has not been studied.	29131152
Renal Cell Carcinoma Pathway	Stem Cell Exhaustion	Impact of HLA-G polymorphism on the outcome of allogeneic hematopoietic stem cell transplantation for metastatic renal cell carcinoma.	29131154
Keratopathy	Stem Cell Exhaustion	To relate central corneal epithelial phenotype to degree of keratopathy in a limbal stem cell deficient population.	29133179
Angiomyolipoma of kidney, Neoplasms, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Renal angiomyolipomas (AML) contain an admixture of clonal tumour cells with features of several different mesenchymal lineages, implying the existence of an unidentified AML neoplastic stem cell.	29133867
Angiomyolipoma of kidney	Stem Cell Exhaustion	Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells.	29133867
Febrile Neutropenia	Stem Cell Exhaustion	Neutropenic fever during peripheral blood progenitor cell mobilization is associated with decreased CD34+ cell collection and increased apheresis collection days.	29134688
Febrile Neutropenia	Stem Cell Exhaustion	Peripheral blood progenitor cell (PBPC) mobilization with chemotherapy in addition to Granulocyte-Colony Stimulating Factor (G-CSF) improves cell collection compared to G-CSF alone; however, it is associated with increased risk of neutropenic fever (NF).	29134688
Exanthema	Stem Cell Exhaustion	Erythematous Rash Following Hematopoietic Stem Cell Transplantation.	29136426
Brain Damage, Chronic, Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplant reflects a complex immune response resulting in chronic damage to multiple tissues.	29138220
Ischemia	Stem Cell Exhaustion	Walking exercise may augment the effects of GM-CSF in PAD, since exercise-induced ischemia enhances progenitor cell release and may promote progenitor cell homing to ischemic calf muscle.	29141087
Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease	Stem Cell Exhaustion	Growing numbers of allogeneic stem cell transplants and improved posttransplant care have led to an increase of individuals with chronic graft-versus-host disease (cGVHD).	29141183
Radiation injury of bone marrow	Stem Cell Exhaustion	Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice.	29141658
McMaster University Epidemiology Terms, Radiation injury	Stem Cell Exhaustion	Protection and/or mitigation of hematopoietic stem cells (HSCs) from radiation injury is an important goal in the development of medical countermeasure agents (MCM).	29141658
Cessation of life	Stem Cell Exhaustion	Neurogenic niches (SVZ and dentate gyrus) were analysed by confocal microscopy using markers of proliferation (Ki-67, PCNA), neuroblasts (PSA-NCAM, DCX, Tuj1), stem cells (Nestin, GFAPd, SOX2, PAX6, Musashi), astrocytes (GFAP, AQ4), oligodendrocytes (NG2, Olig), microglia and cell infiltrates (IBA-1, CD68, MHCII), and cell death (TUNEL).	29141824
Pancytopenia	Stem Cell Exhaustion	Long-term outcome in patients treated at home during the pancytopenic phase after allogeneic haematopoietic stem cell transplantation.	29143281
Pancytopenia	Stem Cell Exhaustion	Patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) were given the option to be treated at home during the pancytopenic phase.	29143281
Childhood Breast Carcinoma, Squamous metaplasia	Stem Cell Exhaustion	Meanwhile, it was positive for CD44 variant isoforms (CD44v), which is a breast cancer stem cell (CSC) marker, and expressed in LGASC, squamous metaplasia, and ASP.	29145336
Mantle cell lymphoma	Stem Cell Exhaustion	R-hyper-CVAD versus R-CHOP/cytarabine with high-dose therapy and autologous haematopoietic stem cell support in fit patients with mantle cell lymphoma: 20 years of single-center experience.	29147847
Medial collateral ligament	Stem Cell Exhaustion	At the University Hospital Zurich, advanced MCL in physically fit patients is treated either with rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone induction followed by consolidating high-dose chemotherapy and autologous stem cell support (R-CHOP/HD-ASCT), or with rituximab plus fractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone alternating with high-dose methotrexate-cytarabine (R-hyper-CVAD/MTX-AraC) without consolidating HD-ASCT upon physicians' and patients' choice.	29147847
Ischemic stroke	Stem Cell Exhaustion	Mobilization of endothelial progenitor cell in patients with acute ischemic stroke.	29147957
Gastrointestinal mucositis	Stem Cell Exhaustion	Influence of Oral Anaerobic Bacteria on Hematopoietic Stem Cell Transplantation Patients: Oral Mucositis and General Condition.	29149979
PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Treatment of relapsed AML and MDS after allogeneic stem cell transplantation with decitabine and DLI-a retrospective multicenter analysis on behalf of the German Cooperative Transplant Study Group.	29151133
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Autologous stem cell transplantation and stem cell mobilization kinetics in elderly patients with B cell non-Hodgkin lymphoma.	29153347
Aggressive Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation (HSCT) is the standard treatment modality in chemotherapy-sensitive relapsed or refractory aggressive lymphomas.	29153347
Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	Even in the modern era of targeted therapies, allogeneic hematopoietic stem cell transplantation (allo-HCT) can offer a chance of extended survival in B cell non-Hodgkin lymphoma (B-NHL) patients who relapse after or are deemed ineligible for autologous transplantation.	29155319
Non-Neoplastic Hematologic and Lymphocytic Disorder	Stem Cell Exhaustion	Haploidentical stem cell transplantation (haplo-SCT) provides an alternative method to cure patients with malignant and nonmalignant hematologic diseases who lack a human leukocyte antigen (HLA) matched related or unrelated donor.	29155367
Fibrosis Assessment	Stem Cell Exhaustion	Hepatic progenitor cells (HPCs) and hepatic stellate cells (HSCs) have been implicated in fibrosis progression in chronic HCV.	29155473
Fibrosis Assessment	Stem Cell Exhaustion	Hepatic progenitor cells and stellate cells play a significant role in the development and progression of fibrosis in chronic HCV.	29155473
Specialty Type - cancer, Adult Glioblastoma, Neoplasms	Stem Cell Exhaustion	The Invasive Region of Glioblastoma Defined by 5ALA Guided Surgery Has an Altered Cancer Stem Cell Marker Profile Compared to Central Tumour.	29156557
Degenerative polyarthritis	Stem Cell Exhaustion	Modulation of Gene Expression in Infrapatellar Fat Pad-Derived Mesenchymal Stem Cells in Osteoarthritis.	29156945
Degenerative polyarthritis, Abnormal degeneration	Stem Cell Exhaustion	Conclusion OA of the knee also affects the mesenchymal stem cells of Hoffa fat, suggesting that Hoffa fat is a new actor in the OA degenerative process that can contribute to the origin, onset, and progression of the disease.	29156945
Neoplasms, Childhood Craniopharyngioma	Stem Cell Exhaustion	Stem cells have been discovered as key players in the genesis of different neoplasms including craniopharyngioma (CP), a rare tumour entity in the sellar region.	29158570
Neoplasms, Childhood Breast Carcinoma	Stem Cell Exhaustion	Claudin-6 (CLDN6), a critical tight junction protein acting as a tumor suppressor in breast cancer, is also considered to be a stem cell marker.	29159771
Triple-Negative Breast Cancer Finding, Childhood Breast Carcinoma	Stem Cell Exhaustion	Triple-negative breast cancer (TNBC) is a subtype of claudin-low and stem cell-like breast cancer which is chemoresistant to multiple anti-cancer drugs.	29159771
Specialty Type - cancer	Stem Cell Exhaustion	Together, we conclude that CLDN6 enhances the chemoresistance to ADM via activating the AF-6/ERK signaling pathway and up-regulating cancer stem cell characters in MDAMB231 cells.	29159771
Keratopathy, Aniridia	Stem Cell Exhaustion	Patients with aniridia often develop aniridia-related keratopathy (ARK), due to limbal stem cell insufficiency.	29162348
Hematopoietic Stem Cell Mobilization	Stem Cell Exhaustion	Biosimilar filgrastim (Leucostim(r)) was shown to be similar in terms of efficacy and safety in hematopoietic progenitor cell mobilization (HPCM) compared to originator filgrastim (Neupogen(r)) and lenograstim (Granocyte(r)) in healthy donors and chemomobilization settings.	29162397
Hematologic Neoplasms	Stem Cell Exhaustion	Allogeneic peripheral blood stem cell (APBSCs) transplantation is an effective treatment for hematological malignancies.	29162400
Adult Glioblastoma	Stem Cell Exhaustion	Dual-targeting immunoliposomes using angiopep-2 and CD133 antibody for glioblastoma stem cells.	29162480
Adult Glioblastoma, Neoplasms, Glioblastoma	Stem Cell Exhaustion	Glioblastoma stem cells (GSCs), which are identified as subpopulation of CD133+/ALDH1+, are known to show resistance to the most of chemotherapy and radiation therapy, leading to the recurrence of tumor in glioblastoma multiforme (GBM) patients.	29162480
Lymphoma, Non-Hodgkin, Familial, Hodgkin Disease, Childhood Non-Hodgkin Lymphoma	Stem Cell Exhaustion	The combination of carmustine, etoposide, aracytin, and melphalan(BEAM) conditioning regimen in autologous stem-cell transplantation (ASCT) is widely used in patients with relapsed/refractory non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma.	29164977
Dysplasia	Stem Cell Exhaustion	A combination of proteins mucin-5AC and prostate stem-cell antigen could identify high-grade dysplasia/cancer with an accuracy of 96% (95% CI, 90% to 99%), and detected 95% of malignant/severely dysplastic lesions, compared with 35% and 50% for carcinoembryonic antigen and cytology ( P < .001 and P = .003, respectively).	29166170
Graft-vs-Host Disease	Stem Cell Exhaustion	Gastrointestinal (GI) graft-versus-host-disease (GVHD) is a common and severe complication of allogeneic hematopoietic stem cell transplantation, but clinical and histological features are unspecific.	29167990
Infections, Hospital, Clostridium difficile	Stem Cell Exhaustion	Screening for Clostridium difficile colonization on admission to a hematopoietic stem cell transplant unit may reduce hospital-acquired C difficile infection.	29169936
Clostridium difficile colitis	Stem Cell Exhaustion	Clostridium difficile infection rates are higher in patients undergoing hematopoietic stem cell transplants.	29169936
Colonization	Stem Cell Exhaustion	In our study, patients undergoing hematopoietic stem cell transplants or chemotherapy were screened for C difficile colonization at admission and placed on contact precautions if they were positive.	29169936
Pulmonary Dysfunction	Stem Cell Exhaustion	Obstructive and restrictive pulmonary dysfunction in long-term lymphoma survivors after high-dose therapy with autologous stem cell transplantation.	29171324
physiopathological	Stem Cell Exhaustion	Obstructive and restrictive dysfunction in long-term lymphoma survivors (LSs) after high-dose therapy with autologous stem-cell transplantation (HDT-ASCT) has not been addressed systematically previously.	29171324
Glycogen Storage Disease Type IIb	Stem Cell Exhaustion	Characteristics of induced pluripotent stem cells from clinically divergent female monozygotic twins with Danon disease.	29175505
Glycogen Storage Disease Type IIb	Stem Cell Exhaustion	Induced pluripotent stem cells (iPSCs) have been generated from patients with various forms of disease, including Danon disease (DD); however, few reports exist regarding disease-specific iPSCs derived from clinically divergent monozygotic twins.	29175505
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Minimal residual disease by either flow cytometry or cytogenetics prior to an allogeneic hematopoietic stem cell transplant is associated with poor outcome in acute myeloid leukemia.	29176662
Graft-vs-Host Disease, Communicable Diseases	Stem Cell Exhaustion	No indication of increased infection rates using low-dose alemtuzumab instead of anti-thymocyte globulin as graft-versus-host disease prophylaxis before allogeneic stem cell transplantation.	29178248
Cytomegalovirus, Fever, Toxoplasmosis, Communicable Diseases	Stem Cell Exhaustion	We performed a retrospective, single-center, case-control study analyzing the rates of neutropenic fever, cytomegalovirus (CMV) reactivation, Epstein-Barr virus (EBV) reactivation, clinical manifest toxoplasmosis, and clinical manifest human herpesvirus-6 (HHV6) infection using low-dose alemtuzumab in comparison with anti-thymocyte globulin (ATG) as GvHD prophylaxis before allogeneic stem cell transplantation.	29178248
Infection	Stem Cell Exhaustion	We saw no indication of increased infections rates when using low-dose alemtuzumab as GvHD prophylaxis before allogeneic stem cell transplantation in this retrospective analysis.	29178248
Adult Glioblastoma	Stem Cell Exhaustion	A stem cell marker, CD133, was reported to predict recurrence patterns in intracranial glioblastoma.	29180077
Pituitary Neoplasms, Childhood Craniopharyngioma	Stem Cell Exhaustion	Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma.	29180744
Neoplasms	Stem Cell Exhaustion	We show that expression of oncogenic b-catenin in Hesx1+ embryonic precursors also results in stem cell clusters and paracrine tumours.	29180744
Neoplasms	Stem Cell Exhaustion	Together, we provide evidence that senescence and a stem cell-associated SASP drive cell transformation and tumour initiation in vivo in an age-dependent fashion.	29180744
Neoplasms, American College of Physicians, Adamantinous Craniopharyngioma	Stem Cell Exhaustion	Expression of oncogenic b-catenin in Sox2+ young adult pituitary stem cells leads to formation of clusters of stem cells and induction of tumours resembling human adamantinomatous craniopharyngioma (ACP), derived from Sox2- cells in a paracrine manner.	29180744
HIV-1 Infection Pathway	Stem Cell Exhaustion	Notwithstanding 1 documented case of HIV-1 cure following allogeneic stem cell transplantation (allo-SCT), several subsequent cases of allo-SCT in HIV-1 positive individuals have failed to cure HIV-1 infection.	29182633
Subglottic stenosis	Stem Cell Exhaustion	The aim of this study was to evaluate the effect of human adipose tissue-derived mesenchymal stem cells (hAMSCs) in rat model of subglottic stenosis.	29185355
Kidney Failure, Chronic, Thoracic spinal cord structure	Stem Cell Exhaustion	Improvement of renal function after human umbilical cord mesenchymal stem cell treatment on chronic renal failure and thoracic spinal cord entrapment: a case report.	29187247
Kidney Failure, Chronic	Stem Cell Exhaustion	Mesenchymal stem cell studies in animal models of chronic renal failure have uncovered a unique potential of these cells for improving function and regenerating the damaged kidney.	29187247
Kidney Failure, Entrapment of Device	Stem Cell Exhaustion	Human umbilical cord mesenchymal stem cell implantations led to significant improvement for spinal cord entrapment and kidney failure.	29187247
Specialty Type - cancer, Malignant Neoplasms	Stem Cell Exhaustion	Conclusion: By considering these results as the fundamental information for MIS, our system could be applied to induce senescence in treatment-resistant cancers such as metastatic cancer or cancer stem cells.	29187894
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	Although patient-sourced cardiac explant-derived stem cells (EDCs) provide an exogenous source of new cardiomyocytes post-myocardial infarction, poor long-term engraftment indicates that the benefits seen in clinical trials are likely paracrine-mediated.	29187908
Myocardial	Stem Cell Exhaustion	Silencing IL-6 in EDCs abrogated much of the benefits conferred by cell transplantation and revealed that IL-6 prompts cardiac fibroblasts and macrophages to reduce myocardial scarring while increasing the generation of new cardiomyocytes and recruitment of blood stem cells.	29187908
Acute lymphocytic leukemia	Stem Cell Exhaustion	10-year complete remission in a Philadelphia chromosome-positive acute lymphoblastic leukemia patient using imatinib without high-intensity chemotherapy or allogeneic stem cell transplantation.	29188580
Adult Glioblastoma	Stem Cell Exhaustion	Determinants for Effective ALECSAT Immunotherapy Treatment on Autologous Patient-Derived Glioblastoma Stem Cells.	29190492
Specialty Type - cancer	Stem Cell Exhaustion	Here we performed a paired pre-clinical study to investigate the composition and in vitro effect of ALECSAT and identify determinants for the effect using autologous GBM-derived cancer stem cells (CSC), immunocytochemistry and flow cytometry.	29190492
Degenerative polyarthritis	Stem Cell Exhaustion	CD105+-mesenchymal stem cells migrate into osteoarthritis joint: An animal model.	29190645
Hypertensive (finding)	Stem Cell Exhaustion	Association of circulating progenitor cells with angiotensin II in newly diagnosed hypertensive patients.	29192185
Graft-vs-Host Disease	Stem Cell Exhaustion	The histopathologic diagnosis of hepatic graft-versus-host disease post bone marrow and stem cell transplantation can be challenging, but timely and unambiguous diagnosis is essential for appropriate patient management.	29192646
Liver damage	Stem Cell Exhaustion	Direct thaw and administration of previously cryopreserved peripheral blood stem cell products is a commonly used practice and should be performed rapidly to reduce cellular damage caused by dimethyl sulfoxide exposure.	29193156
Malignant neoplasm of ovary	Stem Cell Exhaustion	Purification of a stem-cell like side-population (SP) from ovarian cancer cell lines was performed by flow cytometry/FACS.	29194596
Malignant neoplasm of ovary	Stem Cell Exhaustion	In conclusion, Vav3.1 is over-expressed in stem-cell like SP fractions and is clinically relevant in the pathophysiology of ovarian cancer.	29194596
Malignant neoplasm of ovary	Stem Cell Exhaustion	Truncated isoform Vav3.1 is highly expressed in ovarian cancer stem cells and clinically relevant in predicting prognosis and platinum-response.	29194596
Peripheral T-Cell Lymphoma	Stem Cell Exhaustion	Optimal salvage therapy for primary refractory peripheral T-cell lymphomas (PTCL) and the role of hematopoietic stem cell transplant (SCT) remain poorly defined.	29194714
Leukemia, Myelomonocytic, Chronic	Stem Cell Exhaustion	Prognostic Impact of Donor Source on Allogeneic Hematopoietic Stem Cell Transplantation Outcomes in Adults with Chronic Myelomonocytic Leukemia: A Nationwide Retrospective Analysis in Japan.	29196081
Leukemia, Myelomonocytic, Chronic	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapeutic option for patients with chronic myelomonocytic leukemia (CMML).	29196081
Lymphoma	Stem Cell Exhaustion	Outcomes after Allogeneic Stem Cell Transplantation in Patients with Double-Hit and Double-Expressor Lymphoma.	29196080
Lymphoma	Stem Cell Exhaustion	Double-hit lymphomas (DHLs) and double-expressor lymphomas (DELs) are associated with resistance to frontline and salvage immunochemotherapy, as well as autologous stem cell transplantation (SCT).	29196080
Neoplasms	Stem Cell Exhaustion	In B-CLL cells, some remarkable unique features like the loss of tumor suppressor molecules PNN and JARID2, the stress-related serotonin transporter SLC6A4, and high expression of ZNF207, CCDC88A, PIGR and ID3, otherwise associated with stem cell phenotype, were determined.	29196338
Neoplasms, Specialty Type - cancer	Stem Cell Exhaustion	Pathway enrichment, predicted drug response, tumor microenvironment infiltration, cancer immunotherapy antigen profiling, and miRNA target enrichment were assessed.Results: AA-enriched differential gene expression was characterized by stem cell and invasion pathways.	29196495
Congenital Abnormality, LMNA wt Allele, Cockayne Syndrome	Stem Cell Exhaustion	By using the redifferentiation of four patient-derived induced pluripotent stem cells as a model for the onset of progeroid syndromes, we tracked the progression of RT abnormalities during development, revealing altered RT of the TP63 gene as an early event in disease progression of both HGPS and RTS.	29196523
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease (aGVHD) is 1 of the main major complications of post-hematopoietic stem cell transplantation (HSCT).	29197674
Graft-vs-Host Disease	Stem Cell Exhaustion	Various approaches have been developed for ex vivo T cell depletion in allogeneic stem cell transplantation to prevent graft-versus-host disease (GVHD).	29197677
Gastrointestinal mucositis	Stem Cell Exhaustion	Burden of oral mucositis in stem cell transplant patients-the patients' perspective.	29197961
Gastrointestinal mucositis	Stem Cell Exhaustion	Purpose of this study was to determine the impact of Oral Mucositis (OM) on health-related quality of life (HRQoL) and quality of life associated symptoms and functions in patients undergoing hematopoietic stem cell transplantation (HSCT).	29197961
Nocardia Infections, Inappropriate ADH Syndrome	Stem Cell Exhaustion	The syndrome of inappropriate antidiuretic hormone secretion (SIADH) has been described thus far in lung and stem cell transplants with systemic nocardiosis.	29198680
Graft-vs-Host Disease	Stem Cell Exhaustion	Anti-thymocyte globulin (ATG) is often added to hematopoietic stem cell transplant conditioning regimens to prevent graft rejection and reduce graft-versus-host disease (GVHD).	29199482
Multiple Myeloma	Stem Cell Exhaustion	The mainstay of treatment of myeloma is induction treatment followed by consolidation with autologous stem cell transplant (ASCT).	29199718
Hyperkalemia, Nephrotoxic	Stem Cell Exhaustion	Of note, hyperkalemia was observed in more patients who received allogeneic hematopoietic stem cell transplantation (P=0.0303) and concomitant treatment with nephrotoxic drugs (P=0.0281).	29203252
Malignant Neoplasms, Neoplasms, Secondary Neoplasm	Stem Cell Exhaustion	Twist1 is a key transcription factor, which confers tumor cells with cancer stem cell (CSC)-like characteristics and enhances epithelial-mesenchymal transition in pathological conditions including tumor malignancy and metastasis.	29204790
Osteoporosis, Postmenopausal	Stem Cell Exhaustion	In vitro cell behaviors of bone mesenchymal stem cells derived from normal and postmenopausal osteoporotic rats.	29207050
Squamous cell carcinoma	Stem Cell Exhaustion	Adipose-derived stem cell conditioned medium attenuates cisplatin-triggered apoptosis in tongue squamous cell carcinoma.	29207154
Apoptosis	Stem Cell Exhaustion	Moreover, adipose-derived stem cell conditioned medium markedly inhibited cisplatin-induced apoptotic cell death (sub-G1 phase) in the CAL-27 cells.	29207154
Cessation of life	Stem Cell Exhaustion	Taken together, we provide evidence that adipose-derived stem cell conditioned medium protects CAL-27 cells from cisplatin-induced cell death, possibly through upregulation of the IGF-1R/AKT/ERK signaling pathway.	29207154
Specialty Type - cancer	Stem Cell Exhaustion	To evaluate the interaction of tongue cancer cells and adipose-derived stem cells, we performed a series of in vitro experiments.	29207154
Damage	Stem Cell Exhaustion	Mesenchymal stem cell (MSC)-based therapies have had positive outcomes in the treatment of DOXO-induced cardiac damage; however, DOXO exerts toxic effects on MSCs, decreasing the effectiveness of MSC therapy.	29207187
doxorubicin	Stem Cell Exhaustion	Macrophage migration inhibitory factor rescues mesenchymal stem cells from doxorubicin-induced senescence though the PI3K-Akt signaling pathway.	29207187
Cessation of life, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Treatment with combined VS-5584, SCH772984, and ABT-199 showed significant increase in cell death in AML cell lines and primary patient samples and significant reduction in AML colony formation in primary patient samples, while there was no significant effect on colony formation of normal human CD34+ hematopoietic progenitor cells.	29208365
Electrocardiogram: myocardial infarction (finding)	Stem Cell Exhaustion	TIME Trial: Effect of Timing of Stem Cell Delivery Following ST-Elevation Myocardial Infarction on the Recovery of Global and Regional Left Ventricular Function: Final 2-Year Analysis.	29208679
Rheumatoid Arthritis	Stem Cell Exhaustion	Articular and subcutaneous adipose tissues of rheumatoid arthritis patients represent equal sources of immunoregulatory mesenchymal stem cells.	29212384
TAO brand of troleandomycin, Thyroid associated opthalmopathies	Stem Cell Exhaustion	The purpose of this study was to characterize the intrinsic cellular properties of orbital adipose-derived stem cells (OASC) from patients with thyroid-associated orbitopathy (TAO) and healthy controls.	29214313
Toxic effect, Multiple Myeloma	Stem Cell Exhaustion	Melphalan at a dose of 200 mg/m2 is standard conditioning prior to autologous hematopoietic stem cell transplantation for multiple myeloma, but a dose of 140 mg/m2 is often used in clinical practice in patients perceived to be at risk of excess toxicity.	29217776
Neoplasms, Multiple Myeloma	Stem Cell Exhaustion	Prognostic significance of tumor burden assessed by whole-body magnetic resonance imaging in multiple myeloma patients treated with allogeneic stem cell transplantation.	29217779
Multiple Myeloma	Stem Cell Exhaustion	Allogeneic stem cell transplantation is a therapeutic option under dispute but nonetheless chosen with increasing frequency for patients suffering from multiple myeloma in Europe.	29217779
Neoplasms	Stem Cell Exhaustion	To study possible predictors of survival, 79 patients were investigated using whole-body magnetic resonance imaging to assess the visible tumor burden before and after allogeneic stem cell transplantation.	29217779
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	As surrogate for changes in management, we found an increase of allogeneic haematopoietic stem cell transplantations (1.4 to 7%) and clinical trial activities (25 to 29%) for elderly AML patients during the observation period.	29223104
Amyloidosis	Stem Cell Exhaustion	Adverse Prognostic Factors for Morbidity and Mortality During Peripheral Blood Stem Cell Mobilization in Patients with Light Chain Amyloidosis.	29223373
Hematopoietic stem cells, Amyloidosis	Stem Cell Exhaustion	Patients with immunoglobulin light chain (AL) amyloidosis undergoing peripheral blood hematopoietic stem cell (PBSC) mobilization for autologous hematopoietic stem cell transplantation (auto-HCT) can experience significant morbidity and mortality.	29223373
Rhabdoid Tumor	Stem Cell Exhaustion	We report a 7-week-old female with metastatic AT/RT and synchronous malignant rhabdoid tumor of the kidney who received an intensive multimodal approach combining surgical resection, intrathecal chemotherapy, and high-dose chemotherapy with autologous peripheral blood stem cell transplant (PBSCT).	29223518
Tachypnea	Stem Cell Exhaustion	In a multivariate analysis, history of autologous stem cell transplantation (HR, 31.151; 95% CI, 5.447-178.145; P < 0.001) and tachypnea at ED (HR, 4.392; 95% CI, 1.402-13.761; P = 0.011) were significantly associated with MERS-CoV infection.	29223614
Pancreatic carcinoma	Stem Cell Exhaustion	Doublecortin-like kinase 1 (DCLK1) is emerging as a tumor-specific stem cell marker in pancreatic cancer (PC).	29224010
Histiocytic Disorders, Malignant, Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cell and its niche in malignant progression of oral potentially malignant disorders.	29224811
Histiocytic Disorders, Malignant, Specialty Type - cancer	Stem Cell Exhaustion	The purpose of this study was to determine association between cancer stem cells (CSCs) and their niche with progression of oral potentially malignant disorders.	29224811
Lymphohistiocytosis, Hemophagocytic	Stem Cell Exhaustion	A 16-year-old boy with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (HLH) underwent allogeneic hematopoietic stem cell transplantation after conditioning with fludarabine, melphalan, total body irradiation, and rabbit antithymocyte globulin (ATG).	29225252
Degenerative polyarthritis	Stem Cell Exhaustion	Adipose-derived mesenchymal stem cells (ASC) are attractive candidates in the search of novel strategies for OA treatment and exert anti-inflammatory and cytoprotective effects on cartilage.	29230269
Multiple Myeloma	Stem Cell Exhaustion	The combination of bortezomib, melphalan, and prednisone is a standard treatment for patients with newly diagnosed multiple myeloma who are ineligible for autologous stem-cell transplantation.	29231133
Multiple Myeloma	Stem Cell Exhaustion	In this phase 3 trial, we randomly assigned 706 patients with newly diagnosed multiple myeloma who were ineligible for stem-cell transplantation to receive nine cycles of bortezomib, melphalan, and prednisone either alone (control group) or with daratumumab (daratumumab group) until disease progression.	29231133
Cessation of life, Multiple Myeloma	Stem Cell Exhaustion	Among patients with newly diagnosed multiple myeloma who were ineligible for stem-cell transplantation, daratumumab combined with bortezomib, melphalan, and prednisone resulted in a lower risk of disease progression or death than the same regimen without daratumumab.	29231133
Degenerative polyarthritis	Stem Cell Exhaustion	Consequently, OA has been associated with defects in the chondrocitic differentiation of progenitor stem cells (PSCs).	29236045
Degenerative polyarthritis	Stem Cell Exhaustion	To evaluate the effects of the non-amino bisphosphonate clodronate in OA patients we investigated SOX9 gene expression in circulating progenitor cells (CPCs) and in an in vitro OA model.	29236045
Aplastic Anemia	Stem Cell Exhaustion	Prognosis of hepatitis-associated aplastic anaemia (HAAA) was improved with haematopoietic stem cell transplantation (HSCT) and immunosuppression, but the long-term outcome remains undefined.	29237659
Cerebrovascular accident	Stem Cell Exhaustion	Endothelial progenitor cells enhance blood-brain barrier permeability in subacute stroke.	29237797
Ischemic stroke	Stem Cell Exhaustion	To study the association among endothelial progenitor cells (EPCs), subacute blood-brain barrier (BBB) permeability, and clinical outcome after ischemic stroke, determining the micro RNAs of EPCs responsible for good clinical outcome.	29237797
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Adults (ages 18-75 years) with non-Hodgkin's lymphoma in first or second complete or partial remission, without previous hematopoietic stem cell mobilization or autologous transplant, were included.	29238988
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	Plerixafor and granulocyte-colony-stimulating factor for mobilization of hematopoietic stem cells for autologous transplantation in Chinese patients with non-Hodgkin's lymphoma: a randomized Phase 3 study.	29238988
Lymphoma, Non-Hodgkin	Stem Cell Exhaustion	This Phase 3 randomized, double-blind study evaluated the efficacy and safety of plerixafor plus granulocyte-colony-stimulating factor for the mobilization of hematopoietic stem cells in Chinese patients with non-Hodgkin's lymphoma.	29238988
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	A substantial proportion of patients with acute graft-versus-host disease (aGVHD) respond to cell therapy with culture-expanded human bone marrow mesenchymal stromal/stem cells (BM-MSCs).	29239062
Neutropenia, Hematologic Neoplasms	Stem Cell Exhaustion	A total of 152 febrile neutropenia (FEN) patients with hematological malignancies aged over 18 years and receiving high-dose chemotherapy or stem cell transplant between January 1, 2010, and December 31, 2012 were included in the study.	29239468
Degenerative polyarthritis	Stem Cell Exhaustion	Progenitor cells from different zones of human cartilage and their correlation with histopathological osteoarthritis progression.	29240251
Degenerative polyarthritis	Stem Cell Exhaustion	This study focused on quantitative assessment of the concentration and biological potential of stem and progenitor cells resident in different zones of cartilage displaying macroscopic Outerbridge grade 1-2 OA, and their correlation with OA progression based on established histologic scoring system.	29240251
leukemia, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Allogeneic stem cell transplantation benefits for patients >= 60 years with acute myeloid leukemia and FLT3 internal tandem duplication: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.	29242299
FLT3 Internal Tandem Duplication, Cytogenetically normal acute myeloid leukemia	Stem Cell Exhaustion	Intermediate-risk cytogenetic acute myeloid leukemia with an internal tandem duplication of FLT3 (FLT3-ITD) is associated with a high risk of relapse, and is now a standard indication for allogeneic stem cell transplantation.	29242299
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Prospective randomization of post-remission therapy comparing autologous peripheral blood stem cell transplantation versus high-dose cytarabine consolidation for acute myelogenous leukemia in first remission.	29243031
International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) Criteria - Favorable-Risk Group, Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	We prospectively compared outcomes of autologous stem cell transplantation (ASCT) versus high-dose cytarabine (HiDAC) consolidation as post-remission therapy for favorable- and intermediate-risk acute myelogenous leukemia (AML) in first complete remission (CR1).	29243031
Specialty Type - cancer, Refractory Cytopenia of Childhood	Stem Cell Exhaustion	Thus, the present study was conducted to evaluate the expression and prognostic significance of CD44 as a cancer stem cell marker in different histological subtypes of RCC.	29243496
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cell marker CD44 may be a promising target for cancer treatment only in ccRCC.	29243496
Atrial Fibrillation by ECG Finding	Stem Cell Exhaustion	Preferential myofibroblast differentiation of cardiac mesenchymal progenitor cells in the presence of atrial fibrillation.	29245016
Myeloid Leukemia, Chronic	Stem Cell Exhaustion	Copper-associated hepatitis in a patient with chronic myeloid leukemia following hematopoietic stem cell transplantation: A case report.	29245301
Alport Syndrome, Autosomal Recessive	Stem Cell Exhaustion	Integration-free induced pluripotent stem cells derived from a patient with autosomal recessive Alport syndrome (ARAS).	29246570
Alzheimers Disease	Stem Cell Exhaustion	Generation and characterization of human induced pluripotent stem cell (hiPSC) lines from an Alzheimer's disease (ASUi003-A) and non-demented control (ASUi004-A) patient homozygous for the Apolipoprotein e4 (APOE4) risk variant.	29246571
Up, Nested Diagnostic Context	Stem Cell Exhaustion	Here, we generated human induced pluripotent stem cell (hiPSC) lines from the peripheral blood mononuclear cells (PBMCs) of a clinically diagnosed AD patient [ASUi003-A] and a non-demented control (NDC) patient [ASUi004-A] homozygous for the APOE4 risk allele.	29246571
Carcinoma of larynx	Stem Cell Exhaustion	Development of one control and one tumor-specific induced pluripotent stem cell line from laryngeal carcinoma patient.	29246575
Neoplasms	Stem Cell Exhaustion	Control and tumor specific induced pluripotent stem cells were reprogrammed with 5 reprogramming factors, Klf-4, c-Myc, Oct-4, Sox-2, and Lin-28, using the messenger RNA reprogramming system.	29246575
Multiple Myeloma	Stem Cell Exhaustion	Vinorelbine combined with filgrastim at a dose of 10 ug/kg of body weight (BW) per day is a reliable and well-tolerated regimen for mobilization of hematopoietic progenitor cells (HPCs) in patients with multiple myeloma.	29246820
Vascular smooth muscle cell, Vascular System Injuries	Stem Cell Exhaustion	MicroRNA-22 (miR-22) has recently been reported to play a regulatory role during vascular smooth muscle cell (VSMC) differentiation from stem cells, but little is known about its target genes and related pathways in mature VSMC phenotypic modulation or its clinical implication in neointima formation following vascular injury.	29246895
Malignant Neoplasms	Stem Cell Exhaustion	Ipilimumab plus Lenalidomide after Allogeneic and Autologous Stem Cell Transplantation for Patients with Lymphoid Malignancies.	29246938
Malignant Neoplasms	Stem Cell Exhaustion	Purpose: Prevention or treatment of relapsed lymphoid malignancies after hematopoietic stem cell transplantation (HSCT) requires novel strategies.	29246938
leukemia	Stem Cell Exhaustion	Allogeneic Stem Cell Transplantation versus Tyrosine Kinase Inhibitors Combined with Chemotherapy in Patients with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.	29247779
B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1, BCR gene	Stem Cell Exhaustion	Here we compare outcomes between the tyrosine kinase inhibitors (TKIs) plus chemotherapy regimen and allogeneic hematopoietic stem cell transplantation (transplantation cohort) in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) and explore factors associated with prognosis.	29247779
BCR gene	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation confers significant survival advantages for Ph+ ALL patients compared with TKIs plus chemotherapy, especially in intermediate- and high-risk patients.	29247779
leukemia	Stem Cell Exhaustion	Intravenous Busulfan Compared with Treosulfan-Based Conditioning for Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia: A Study on Behalf of the Acute Leukemia Working Party of European Society for Blood and Marrow Transplantation.	29247780
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Dose intensity of the conditioning regimen has significant impact on the outcomes after stem cell transplantation (SCT) for acute myeloid leukemia.	29247780
Hematological Disease	Stem Cell Exhaustion	We evaluated the impact of unidirectional donor versus recipient killer cell immunoglobulin-like receptor (KIR)-ligand mismatch (KIR-Lmm) on the outcomes of T cell-replete haploidentical stem cell transplantation (Haplo-SCT) with post-transplant cyclophosphamide (PT-Cy) in a cohort of 144 patients treated for various hematologi diseases.	29247781
Hematologic Neoplasms, Hematopoiesis	Stem Cell Exhaustion	Imaging of subclinical haemopoiesis after stem-cell transplantation in patients with haematological malignancies: a prospective pilot study.	29248669
leukemia	Stem Cell Exhaustion	National Institutes of Health, Ben's Run/Ben's Gift, Albert and Elizabeth Tucker Foundation, Mex Frates Leukemia Fund, Jones Family fund, and Oklahoma Center for Adult Stem Cell Research.	29248669
Childhood Breast Carcinoma, Resistance Process	Stem Cell Exhaustion	JAK/STAT3-Regulated Fatty Acid b-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance.	29249690
Specialty Type - cancer	Stem Cell Exhaustion	Cancer stem cells (CSCs) are critical for cancer progression and chemoresistance.	29249690
Nephrotic Syndrome	Stem Cell Exhaustion	Nephrotic syndrome after autologous hematopoietic stem cell transplantation: a case report.	29250696
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Expression of multiple leukemic stem cell markers is associated with poor prognosis in de novo acute myeloid leukemia.	29251166
Leukemia, Myelocytic, Acute	Stem Cell Exhaustion	Leukemic stem cells (LSCs) play a crucial role in chemotherapy resistance in acute myeloid leukemia (AML).	29251166
Liver carcinoma, Hollings Cancer Center, Malignant neoplasm of liver	Stem Cell Exhaustion	Cluster of differentiation (CD)90 (Thy-1) was proposed as a marker for the liver cancer stem cells that are responsible for tumorigenic activity, however its involvement in the progression of hepatocellular carcinoma (HCC) remains unknown.	29251325
Lymphoma	Stem Cell Exhaustion	Bone Marrow Versus Peripheral Blood Stem Cell Transplant in Lymphoma: A Systematic Review and Meta-Analysis.	29251579
Lymphoma	Stem Cell Exhaustion	Studies that compared bone marrow transplant versus peripheral blood stem cell transplant in lymphoma patients were searched.	29251579
Hematologic Neoplasms	Stem Cell Exhaustion	High-dose chemotherapy alongside peripheral blood stem cell (PBSC) infusion has become the standard of care in different hematologic malignancies.	29255168
Chronic Lymphocytic Leukemia, Malignant Neoplasms	Stem Cell Exhaustion	Outcomes of haploidentical stem cell transplantation for chronic lymphocytic leukemia: a retrospective study on behalf of the chronic malignancies working party of the EBMT.	29255169
Chronic Lymphocytic Leukemia	Stem Cell Exhaustion	Allogeneic hematopoietic stem cell transplantation (HCT) may result in long-term disease control in high-risk chronic lymphocytic leukemia (CLL).	29255169
Muscular Dystrophy, Duchenne	Stem Cell Exhaustion	This enrichment and maturation strategy restored dystrophin in hundreds of dystrophin-deficient myofibres after engraftment of CRISPR-Cas9-corrected Duchenne muscular dystrophy human induced pluripotent stem cell-SMPCs.	29255171
Systemic Scleroderma	Stem Cell Exhaustion	Safety profile of autologous hematopoietic stem cell mobilization and transplantation in patients with systemic sclerosis.	29256111
Toxic effect	Stem Cell Exhaustion	Autologous hematopoietic stem cell transplantation (AHSCT) is thought to be effective therapeutic approach in patients with poor prognosis systemic sclerosis; however, the toxicity remains a challenge.	29256111
Diabetes Mellitus, Insulin-Dependent	Stem Cell Exhaustion	We were the first to demonstrate that stem cells obtained from the pulp of natal teeth could be differentiated into insulinproducing cells, which might prove useful in the stem cell therapy for type 1 diabetes.	29256855
Diabetes Mellitus	Stem Cell Exhaustion	Mesenchymal stem cells have the ability to differentiate into insulin-producing cells, raising the hope for diabetes mellitus treatment.	29256855
Palmar-plantar erythrodysesthesia syndrome	Stem Cell Exhaustion	Here we investigated whether chemotherapy-induced senescence could change stem-cell-related properties of malignant cells.	29258294
Lymphoma	Stem Cell Exhaustion	Gene expression and functional analyses comparing senescent and non-senescent B-cell lymphomas from Em-Myc transgenic mice revealed substantial upregulation of an adult tissue stem-cell signature, activated Wnt signalling, and distinct stem-cell markers in senescence.	29258294
Leukemia, Myelocytic, Acute, Acute lymphocytic leukemia	Stem Cell Exhaustion	Notably, the temporary enforcement of senescence in p53-regulatable models of acute lymphoblastic leukaemia and acute myeloid leukaemia was found to reprogram non-stem bulk leukaemia cells into self-renewing, leukaemia-initiating stem cells.	29258294
Multiple Myeloma, BDI - Functional Impairment	Stem Cell Exhaustion	Utility of a patient-reported outcome in measuring functional impairment during autologous stem cell transplant in patients with multiple myeloma.	29260444
Multiple Myeloma	Stem Cell Exhaustion	We aimed to determine the utility of a patient-reported outcome (PRO) as it relates to patient performed testing (PPT) for measuring functional status in multiple myeloma patients after autologous hematopoietic stem cell transplantation (auto-HCT).	29260444
Childhood Breast Carcinoma	Stem Cell Exhaustion	Our results suggest that 2-14 mutations in the genome of breast stem cells are required for normal breast stem cells to become a malignant cell, and 3 gene mutations are most likely to occur in the development of female breast cancer.	29265879
Specialty Type - cancer, Extraocular Cutaneous Sebaceous Carcinoma, Squamous cell carcinoma	Stem Cell Exhaustion	We herein describe the first case of extraocular sebaceous carcinoma accompanied by invasive squamous cell carcinoma, which might have arisen from biphasic differentiation of cancer stem cells.	29266386
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Allogeneic stem cell transplantation (ASCT) represents the only option with a potential cure rate of 30% to 50% in myelodysplastic syndrome (MDS); however, < 5% of patients are optimal candidates for this management.	29268959
Reticulosarcoma, Pneumonia	Stem Cell Exhaustion	A 60-year-old man developed pneumonia after undergoing autologous peripheral blood stem cell transplantation for diffuse large-B cell lymphoma.	29269681
Amyloidosis	Stem Cell Exhaustion	Impact of prior melphalan exposure on stem cell collection in light chain amyloidosis.	29269795
Multiple Myeloma	Stem Cell Exhaustion	Use of melphalan in multiple myeloma was observed to have a deleterious effect on stem cell collection in older studies.	29269795
Amyloidosis	Stem Cell Exhaustion	We retrospectively evaluated stem cell mobilization in 610 patients with AL amyloidosis, of which 79 had prior exposure to melphalan, 167 to other chemotherapeutics, while 364 had no chemotherapy exposure.	29269795
Pneumocystis jiroveci pneumonia	Stem Cell Exhaustion	A prospective study of intravenous pentamidine for PJP prophylaxis in adult patients undergoing intensive chemotherapy or hematopoietic stem cell transplant.	29269796
Pneumocystis jiroveci pneumonia	Stem Cell Exhaustion	Prophylaxis for Pneumocystis jirovecii pneumonia (PJP) is recommended for patients undergoing hematopoietic stem cell transplantation (HSCT) or intensive chemotherapy.	29269796
Fatigue	Stem Cell Exhaustion	Deconditioning, fatigue and impaired quality of life in long-term survivors after allogeneic hematopoietic stem cell transplantation.	29269801
Fatigue	Stem Cell Exhaustion	Long-term survivors after allogeneic hematopoietic stem cell transplantation (allo-HSCT) are at high risk for treatment-related adverse events, that may worsen physical capacity and may induce fatigue and disability.	29269801
Experimental Organism Malignant Hepatocholangiocellular Carcinoma	Stem Cell Exhaustion	Look into hepatic progenitor cell associated trait: Histological heterogeneity of hepatitis B-related combined hepatocellular-cholangiocarcinoma.	29270746
Fibrous Dysplasia, Hodgkin Disease, Retinoblastoma	Stem Cell Exhaustion	Three patients had previous irradiation (2 for retinoblastoma, 1 for fibrous dysplasia) and 1 patient had chemotherapy and stem cell transplantation for Hodgkin lymphoma.	29270859
Degenerative disorder	Stem Cell Exhaustion	Stem cell transplantation has been considered a promising therapy for retinal degenerative diseases.	29273085
Retinal Degeneration	Stem Cell Exhaustion	Adult human periodontal ligament-derived stem cells delay retinal degeneration and maintain retinal function in RCS rats.	29273085
BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 20	Stem Cell Exhaustion	Our findings suggest that programmed differences in infant stem cell metabolism correspond with differences in body composition in early life, a known contributor to obesity risk.	29273781
adiposity	Stem Cell Exhaustion	Altered gene expression and metabolism in fetal umbilical cord mesenchymal stem cells correspond with differences in 5-month-old infant adiposity gain.	29273781
Specialty Type - cancer	Stem Cell Exhaustion	Studying laboratory cell lines as well as clinical specimens indicate that PTC may follow the cancer stem cell (CSC) model.	29274322
Papillary thyroid carcinoma, Specialty Type - cancer	Stem Cell Exhaustion	Subpopulations of cancer stem cells found in papillary thyroid carcinoma.	29274322
Myotonic Dystrophy, IGHD1-7 gene	Stem Cell Exhaustion	Human immortalized Epstein-Barr virus (EBV) lymphoblastoids cells line (LCLs) from a 26-year- old male affected by an adult form of myotonic dystrophy type 1 (DM1) disease and carrying 200 CTG repeats mutation in the blood was used to generate induced pluripotent stem cells (iPSCs) using the Sendai virus expressing KLF4, OCT4, SOX2 and C-MYC.	29274549
Ki-1+ Anaplastic Large Cell Lymphoma, Hodgkin Disease	Stem Cell Exhaustion	Brentuximab vedotin is currently approved for patients with relapsed or refractory Hodgkin's lymphoma who previously received an autologous stem cell transplant or two previous multiagent chemotherapy regimens, and for patients with relapsed or refractory systemic anaplastic large-T-cell lymphoma who previously received at least one chemotherapy regimen.	29276022
Lymphoma	Stem Cell Exhaustion	Management of Advanced and Relapsed/Refractory Extranodal Natural Killer T-Cell Lymphoma: An Analysis of Stem Cell Transplantation and Chemotherapy Outcomes.	29277360
Small cell carcinoma of lung, Neoplasms	Stem Cell Exhaustion	Preclinical studies in small cell lung cancer (SCLC) have shown that hyaluronic acid (HA) can be effectively used to deliver chemotherapy and selectively decrease CD44 expressing (stem cell-like) tumour cells.	29277856
Gastrointestinal mucositis	Stem Cell Exhaustion	Impact of Oral and Gastrointestinal Mucositis on Body Weight Alterations during Hematopoietic Stem Cell Transplantation.	29278934
Gastrointestinal tract structure	Stem Cell Exhaustion	The aim of this study was to evaluate whether digestive tract mucositis is a predictive factor for body weight (BW) alterations during hematopoietic stem cell transplantation (HSCT).	29278934
Infections, Hospital, Forecast of outcome	Stem Cell Exhaustion	Human Parainfluenza Virus Type 3 Infections in Patients with Hematopoietic Stem Cell Transplants: the Mode of Nosocomial Infections and Prognosis.	29279454
Virus Diseases	Stem Cell Exhaustion	There have been a few prospective and comprehensive surveillance studies on the respiratory viral infections (RVIs) among patients undergoing hematopoietic stem cell transplantation (HSCT).	29279454
Antiphospholipid Syndrome, Chronic graft-versus-host disease	Stem Cell Exhaustion	The patient had previously undergone allogeneic hematopoietic stem cell transplantation and had been diagnosed with antiphospholipid syndrome (APS) during the development of chronic graft-versus-host disease.	29279512
Multiple Myeloma	Stem Cell Exhaustion	Analysis of long-term survival in multiple myeloma after first-line autologous stem cell transplantation: impact of clinical risk factors and sustained response.	29282899
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	The widespread use of high-dose therapy and autologous stem cell transplantation (ASCT) as well as the introduction of novel agents have significantly improved outcomes in multiple myeloma (MM) enabling long-term survival.	29282899
Malignant Neoplasms	Stem Cell Exhaustion	Patients had to have continuous membership with drug benefit eligibility and no prior history of stem cell transplant (SCT) or other cancers during the 12 months prior to the index date.	29284347
Cessation of life	Stem Cell Exhaustion	All patients were followed from index TKI therapy until end of study time period (12 December 2014), death, stem cell transplant, or disenrollment from the health plan unless one of the following occurred first: a patient switched their index therapy, or a patient discontinued their index therapy.	29284347
Toxic effect, Multiple Myeloma	Stem Cell Exhaustion	Comparison of conditioning regimen toxicities among autologous stem cell transplantation eligible multiple myeloma patients: High-dose melphalan versus high-dose melphalan and bortezomib.	29284356
Morular Metaplasia of the Endometrium, Multiple Myeloma	Stem Cell Exhaustion	Background Autologous hematopoietic stem cell transplantation (AHSCT) remains the standard of care for younger patients with multiple myeloma (MM).	29284356
Thromboembolic stroke	Stem Cell Exhaustion	Human Neural Stem Cell Extracellular Vesicles Improve Tissue and Functional Recovery in the Murine Thromboembolic Stroke Model.	29285679
Infarction	Stem Cell Exhaustion	Neural stem cell (NSC) and mesenchymal stem cell (MSC) EVs derived from the same pluripotent stem cell (PSC) line were evaluated for changes in infarct volume as well as sensorimotor function.	29285679
PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Utility of 5-Methylcytosine Immunohistochemical Staining to Assess Global DNA Methylation and Its Prognostic Impact in MDS Patients Background: DNA methylation plays a vital role in the pathogenesis of the myelodysplastic syndrome (MDS), a heterogeneous group of clonal hematopoietic stem cell (HSC) disorders.	29286224
Cardiovascular Diseases	Stem Cell Exhaustion	It is a great resource for discovery of novel predictive factors for cardiovascular disease outcomes, including genomics, transcriptomics, protein biomarkers, oxidative stress markers and circulating progenitor cells.	29288185
leukemia, Adult Myelodysplastic Syndrome	Stem Cell Exhaustion	Reduced-Intensity Allogeneic Transplant for Acute Myeloid Leukemia and Myelodysplastic Syndrome Using Combined CD34-Selected Haploidentical Graft and a Single Umbilical Cord Unit Compared with Matched Unrelated Donor Stem Cells in Older Adults.	29288821
Myoclonic Epilepsy, MERRF Syndrome	Stem Cell Exhaustion	Generation of an induced pluripotent stem cell (iPSC) line from a 40-year-old patient with the A8344G mutation of mitochondrial DNA and MERRF (myoclonic epilepsy with ragged red fibers) syndrome.	29288969
Hodgkin Disease, LIPC gene	Stem Cell Exhaustion	Based on promising pilot data a phase II tandem autologous hematopoietic stem cell transplant (AHSCT) trial for relapsed/refractory Hodgkin lymphoma (HL) was performed in the US intergroup setting to determine if long-term progression-free survival (PFS) could be improved.	29289757
Hypertensive (finding), Hypertension, CTCAE	Stem Cell Exhaustion	Objective The aim of this study was to investigate the relationship between peripheral plasma stem cell factor (SCF)/c-kit levels and the types of dipper and non-dipper hypertension in hypertensive patients.	29301598
Alzheimers Disease	Stem Cell Exhaustion	Establishment of induced pluripotent stem cell line (ZZUi009-A) from an Alzheimer's disease patient carrying a PSEN1 gene mutation.	29304399
Fibroid Tumor, Hypoxia	Stem Cell Exhaustion	These hypotheses include the loss of telocytes' functions as "sex hormone sensors" and regulators of smooth muscle cells cycle; the role of telocytes as progenitor cells for the development of leiomyomas; and the hypothesis of decreased angiogenesis after telocytes' loss with subsequent hypoxia (as a key factor for leiomyomas development).	29317071
Scleroderma	Stem Cell Exhaustion	However, subcutaneous injections of autologous adipose tissue-derived stromal vascular fraction (ADSVF), which is known to contain mesenchymal stem cells, in hands of Patients with scleroderma for enhancing their impaired hand function is still in an experimental stage, although there are already promising results of the therapy.	29324934
Prostate carcinoma	Stem Cell Exhaustion	This study explored the association between a single-nucleotide polymorphism of prostate stem cell antigen and prostate cancer in Chinese patients undergoing prostate biopsy.	29332451
Prostate carcinoma	Stem Cell Exhaustion	Men with the rs1045531 AC genotype of prostate stem cell antigen were at higher risk of prostate cancer in Chinese patients undergoing prostate biopsy.	29332451
Impaired cognition	Stem Cell Exhaustion	Hippocampal avoidance during whole-brain radiotherapy is performed to prevent neural stem cell injury causing neurocognitive dysfunction.	29332467
Neoplastic Post-Transplant Lymphoproliferative Disorder, Thalassemia	Stem Cell Exhaustion	Diagnosis and treatment of neoplastic post-transplant lymphoproliferative disorder following hematopoietic stem cell transplant in b-thalassemia: A pediatric case report.	29384898
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	In this report we reviewed the case of a pediatric patient who experienced PTLD after allogeneic hematopoietic stem cell transplantation (HSCT) from a human leukocyte antigen (HLA)-identical sibling.	29384898
Post-transplant lymphoproliferative disorder	Stem Cell Exhaustion	The status of stem cell implantation after transplantation, and graft versus host disease should be evaluated jointly, and rituximab therapy and chemotherapy with BFM-95 may be used for treatment of pediatric PTLD after HSCT.	29384898
Acute lymphocytic leukemia	Stem Cell Exhaustion	Efficacy and safety of autologous peripheral blood stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia: A study protocol for a multicenter exploratory prospective study (Auto-Ph17 study).	29384978
Multiple Myeloma	Stem Cell Exhaustion	Recombinant human thrombopoietin improves the efficacy of intermediate-dose cyclophosphamide plus granulocyte colony-stimulating factor in mobilizing peripheral blood stem cells in patients with multiple myeloma: A cohort study.	29390394
Multiple Myeloma	Stem Cell Exhaustion	The combination of intermediate-dose cyclophosphamide (ID-CTX) and granulocyte colony-stimulating factor (G-CSF) fails to mobilize peripheral blood stem cells (PBSCs) in approximately 20% of treated patients with multiple myeloma (MM).In this cohort study, patients with MM underwent PBSC mobilization with either an ID-CTX plus G-CSF plus recombinant human thrombopoietin (rhTPO) regimen (72 patients; TPO group), or an ID-CTX plus G-CSF regimen (70 patients; non-TPO group).In the TPO group, the median CD34+ harvest was 5.36 x 10 per kg of body weight (0.50-22.39 x 10 per kg of body weight), with a harvest success rate of 91.7% (66/72), and an excellence rate of 55.6% (40/72).	29390394
Cutaneous	Stem Cell Exhaustion	The patient attained partial remission after undergoing 2 rounds of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP regimen) before autologous stem cell transplantation, however, he quickly relapsed and developed new cutaneous lesions.	29390581
Unmedicated Sponge Dosage Form, Dementia	Stem Cell Exhaustion	Late-stage progenitor cells were quantified in the subgranular zone (SGZ) of the hippocampal dentate gyrus of DLB/PDD patients (n = 41) and controls without dementia (n = 15) and compared between treatment groups (unmedicated, SSRIs, acetyl cholinesterase inhibitors [AChEIs], combined SSRIs and AChEIs).	29393203
Cerebrovascular accident	Stem Cell Exhaustion	Endothelial Progenitor Cells influence acute and subacute stroke hemodynamics.	29406889
MYELODYSPLASTIC SYNDROME	Stem Cell Exhaustion	To investigate the frequencies and biological characteristics of CD25 positive hematopoietic stem cells (HSC) in myelodysplastic syndromes.	29407181
Stevens-Johnson Syndrome, Keratitis, Facial paralysis, Keratoconus, Special Handling Code - Dry	Stem Cell Exhaustion	Indications for fitting included limbal stem cell deficiency, post-photorefractive keratectomy (PRK) decentred ablation, pellucid marginal degeneration, Stevens-Johnson syndrome, keratoconus, dry eye, neurotrophic keratitis, exposure keratitis from facial nerve paralysis, and post-radial keratotomy (RK) symptoms.	29426444
Sarcoma, Specialty Type - cancer	Stem Cell Exhaustion	Alterations in cancer stem-cell marker CD44 expression predict oncologic outcome in soft-tissue sarcomas.	29433875
Specialty Type - cancer, Secondary Neoplasm	Stem Cell Exhaustion	Cancer stem cells (CSCs) have been shown to resist chemotherapy and promote metastasis after cytotoxic therapies.	29433875
Adult Glioblastoma	Stem Cell Exhaustion	Upstream stimulating factor1 (USF1) enhances the proliferation of glioblastoma stem cells mainly by activating the transcription of mucin13 (MUC13).	29441861
Adult Glioblastoma	Stem Cell Exhaustion	Firstly, the expression of MUC13 was explored in glioblastoma stem cells (GSCs) and we found that MUC13 was significantly enhanced in GSCs.	29441861
Cutaneous Precancerous Condition, Malignant neoplasm of stomach, Specialty Type - cancer	Stem Cell Exhaustion	Expression of Cancer Stem Cell Marker CD44 and Its Polymorphisms in Patients with Chronic Gastritis, Precancerous Gastric Lesion, and Gastric Cancer: A Cross-Sectional Multicenter Study in Thailand.	29445738
Graft-vs-Host Disease, Acute GVH disease	Stem Cell Exhaustion	Acute graft-versus-host disease (GvHD) is a process that classically has been defined as occurring less than 100 days after stem cell transplant.	29469783
Septic Shock	Stem Cell Exhaustion	A 50-year-old man with diffuse large B-cell lymphoma who had undergone an allogeneic stem cell transplant 20 months previously was admitted for neutropenic septic shock.	29469783
Acute GVH disease	Stem Cell Exhaustion	This case provides particular insight into the diagnosis and management of late-presenting acute GvHD given that it is the first reported case of Stage IV cutaneous acute GvHD more than 12 months after stem cell transplant.	29469783
Acute GVH disease	Stem Cell Exhaustion	In the setting of decreased immunosuppression in a patient with a history of a stem cell transplant, acute graft-versus-host disease must be considered regardless of the time that has elapsed since transplant.	29469783
Specialty Type - cancer	Stem Cell Exhaustion	Nestin is considered to be a cancer stem cell marker.	29517198
Motor retardation	Stem Cell Exhaustion	Allogeneic fetal stem cell transplantation to child with psychomotor retardation - A case report.	29652457
malignant disease, leukemia	Stem Cell Exhaustion	The consequences of autologous and allogeneic stem cell transplantation (stem cells of hematopoiesis), applied in adults and children suffering from leukemia or some other malignant disease, are well-known and sufficiently recognizable in pediatric clinical practice regardless of the indication for the treatment.	29652457
Motor retardation, Epilepsy	Stem Cell Exhaustion	However, the efficacy of fetal stem cell transplantation is unrecognizable when the indications are psychomotor retardation and epilepsy.	29652457
Motor retardation, Epilepsy	Stem Cell Exhaustion	The main aim of allogeneic fetal stem cell transplantation was treatment of psychomotor retardation and epilepsy.	29652457
Psychiatric service	Stem Cell Exhaustion	With the exception of neurological psychiatric problems, a boy aged 9.5 years was in good general health before transplantation with allogeneic fetal stem cells.	29652457
PAFAH1B1 wt Allele	Stem Cell Exhaustion	The only curative treatment for MDS is allogeneic stem cell transplantation (SCT).	29668469
Coronary Arteriosclerosis	Stem Cell Exhaustion	The aim of the study was to evaluate long-term outcome of patients with diffuse coronary artery disease, treated with autologous stem cells injections combined with transmyocardial laser revascularization.	29694766
Hypertensive (finding)	Stem Cell Exhaustion	EFFICACY OF MESENCHYMAL STEM CELLS USED FOR THE IMPROVEMENT CEREBRAL MICROCIRCULATION IN SPONTANEOUSLY HYPERTENSIVE RATS.	30188091
Hypertensive (finding)	Stem Cell Exhaustion	We studied influence of intracerebral transplantation of human mesenchymal stem cells (MSCh) to cerebral microcirculation in young (4 months) and aged (12 months) spontaneously hypertensive rats (SHR).	30188091