| 21166499 |
| Thrombotic Microangiopathies | Stem Cell Exhaustion | Renal thrombotic microangiopathy associated with chronic humoral graft versus host disease after hematopoietic stem cell transplantation. | 21166941 |
| Thrombomodulin Alfa, Thrombotic Microangiopathies | Stem Cell Exhaustion | Thrombotic microangiopathy (TMA) is a known complication of hematopoietic stem cell transplantation (HSCT). | 21166941 |
| Cerebral artery occlusion, Infarction | Stem Cell Exhaustion | We found previously that transplantation of neuronal precursors derived from BG01 human embryonic stem cells reduced infarct volume and improved behavioral outcome after distal middle cerebral artery occlusion (MCAO) in rats. | 21167824 |
| Neoplasms | Stem Cell Exhaustion | Tumor incidence in related hematopoietic stem cell donors. | 21170092 |
| Hematologic Neoplasms | Stem Cell Exhaustion | This single center retrospective cohort study evaluated all HLA-identical sibling pairs with hematopoietic stem cell transplantation (HSCT) for a hematological malignancy, treated from 1974 to 2001 at the University Hospital of Basel. | 21170092 |
| Malignant Neoplasms | Stem Cell Exhaustion | Late malignancies have been discussed as a potential risk for growth factor mobilized donors of hematopoietic stem cells. | 21170092 |
| Neoplasms | Stem Cell Exhaustion | Tumors do occur in donors of hematopoietic stem cells at least at the rate as expected in a normal population; whether incidence exceeds expected rates needs to be determined in larger international cohorts. | 21170092 |
| Sensorineural Hearing Loss (disorder) | Stem Cell Exhaustion | Endothelial progenitor cells in sudden sensorineural hearing loss. | 21171834 |
| BCR gene | Stem Cell Exhaustion | Most older adolescents with ALL can be cured with risk-adjusted intensive chemotherapy without stem-cell transplantation. | 21172890 |
| Rickets, Osteopetrosis | Stem Cell Exhaustion | Coexistence of rickets and osteopetrosis may have adverse effects on clinical response to stem cell transplantation. | 21175093 |
| Multiple Myeloma | Stem Cell Exhaustion | The objective of this investigation was to assess the effect of aprepitant on the pharmacokinetics of high-dose melphalan used as conditioning therapy before blood stem cell transplantation in multiple myeloma. | 21175446 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | HDAC1 binding was significantly increased in AML blasts compared to CD34+ progenitor cells at 130 gene promoters whereas decreased binding was observed at 66 gene promoters. | 21176959 |
| Liver damage | Stem Cell Exhaustion | [Therapeutic effect of autologous bone marrow stem cell transplantation in the treatment of severe liver damage]. | 21177200 |
| Liver damage | Stem Cell Exhaustion | To evaluate the effect of autologous bone marrow stem cell transplantation in the treatment of severe liver damage. | 21177200 |
| Liver damage | Stem Cell Exhaustion | Autologous bone marrow stem cell transplantation can improve the liver function of patients with severe liver damage without causing serious complications. | 21177200 |
| Atrial Fibrillation by ECG Finding | Stem Cell Exhaustion | Identifying the VOM and infusing stem cells may ablate related ganglia autonomic function and offer an innovative treatment for atrial fibrillation. | 21177278 |
| Anemia, Multiple Myeloma | Stem Cell Exhaustion | Donor cell origin of multiple myeloma occurring after allogeneic haematopoietic stem cell transplantation in a patient with refractory anaemia with ring sideroblast. | 21177746 |
| Post-transplant lymphoproliferative disorder | Stem Cell Exhaustion | Post-transplant lymphoproliferative disorder (PTLD) is a rare but life-threatening complication after solid organ and haematopoietic stem cell transplantation. | 21177746 |
| Anemia | Stem Cell Exhaustion | A 40-year-old woman who was diagnosed as having refractory anaemia with ring sideroblast 6 years ago took an ABO mismatched, unrelated allogeneic haematopoietic stem cell transplantation (HSCT) from a 32-year-old healthy male donor. | 21177746 |
| Post-transplant lymphoproliferative disorder, Acute lymphocytic leukemia | Stem Cell Exhaustion | Examining the origin of posttransplant lymphoproliferative disorder in a patient after a second allogeneic hematopoeitic stem cell transplantation for relapsed BCR-ABL positive acute lymphoblastic leukemia. | 21178708 |
| Fibrosis Assessment | Stem Cell Exhaustion | Epithelial-mesenchymal transition may be partially involved in the development of subepithelial corneal fibrosis due to total limbal stem cell deficiency. | 21179238 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Experimental data suggests that bone marrow derived Mesenchymal Stem Cells (MSCs) may contribute to the healing of Myocardial infarction. | 21180034 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder in which the diagnosis is confirmed by detection of a genetic marker: Philadelphia (Ph) chromosome in almost 90% of cases. | 21180244 |
| Hematologic Neoplasms, Respiratory Tract Infections | Stem Cell Exhaustion | Human respiratory syncytial virus (HRSV) is an important cause of respiratory infection in patients with hematological malignancy, particularly hematopoietic stem cell transplant recipients. | 21181932 |
| Delirium | Stem Cell Exhaustion | The neuropsychological course of acute delirium in adult hematopoietic stem cell transplantation patients. | 21183605 |
| Delirium | Stem Cell Exhaustion | We characterize neuropsychological performance in 54 hemapoietic stem cell/bone marrow transplantation (BMT) patients shortly before, during, and after delirium and in BMT patients without delirium and 10 healthy adults. | 21183605 |
| Neoplasms | Stem Cell Exhaustion | Putative CD133(+) brain tumor stem cells have been shown to be located in niches and as single cells. | 21184132 |
| Mesenchymal Stem Cells, Muscle, Smooth, Vascular, Progeria | Stem Cell Exhaustion | A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects. | 21185252 |
| LMNA wt Allele | Stem Cell Exhaustion | To understand the underlying molecular pathology of HGPS, we derived induced pluripotent stem cells (iPSCs) from HGPS dermal fibroblasts. | 21185252 |
| Hemorrhagic cystitis | Stem Cell Exhaustion | Efficacy and safety of ciprofloxacin for prophylaxis of polyomavirus BK virus-associated hemorrhagic cystitis in allogeneic hematopoietic stem cell transplantation recipients. | 21185389 |
| Hemorrhagic cystitis | Stem Cell Exhaustion | Polyoma virus BK-induced hemorrhagic cystitis is an important cause of morbidity after hematopoietic stem cell transplantation (HSCT). | 21185389 |
| leukemia, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | [General calculating model of the needs for allogenic stem cell transplantation for the patients with leukaemia and myelodysplastic syndrome in Vojvodina]. | 21186542 |
| Hematological Disease | Stem Cell Exhaustion | Allogeneic stem cell transplantation (SCT) application represents a treatment of choice that enables the eradication of malignant clone and chance for remedy of the patients with hematological diseases. | 21186542 |
| PAFAH1B1 wt Allele, Myeloid Leukemia, Chronic, Chronic Lymphocytic Leukemia, Leukemia, Myelocytic, Acute, BCR gene | Stem Cell Exhaustion | Total annual needs for allogeneic SCT for the patients suffering from ANLL, ALL, CML, CLL and MDS together, in transplantation with stem cells from their related donors are 786 days, from the unrelated donors are 306 days, while for nonmyeloablative transplantation with stem cells from their related donors are 558 days and from the unrelated ones are 297 days. | 21186542 |
| Neutropenia, Fever, Pregnancy Complications, Infectious, Inflammatory | Stem Cell Exhaustion | Stem cell transplantation (SCT) is still complicated by the occurrence of fever and inflammatory complications attributed to neutropenia and subsequent infectious complications. | 21188146 |
| Myocardial Ischemia | Stem Cell Exhaustion | Improved functional activity of bone marrow derived circulating progenitor cells after intra coronary freshly isolated bone marrow cells transplantation in patients with ischemic heart disease. | 21188654 |
| Myocardial Ischemia | Stem Cell Exhaustion | In this randomized controlled study we analyzed the influence of intracoronary autologous freshly isolated bone marrow cells transplantation by use of point of care system on cardiac function and on the functional activity of bone marrow derived circulating progenitor cells (BM-CPCs) in patients with ischemic heart disease (IHD). | 21188654 |
| Lymphoma, Adverse Event Associated with Secondary Malignancy | Stem Cell Exhaustion | High-dose chemotherapy with peripheral blood progenitor cell (PBPC) autograft is effective in high-risk lymphoma, particularly with the addition of rituximab; however, it is associated with risk of secondary malignancy. | 21189387 |
| Myocardial Ischemia | Stem Cell Exhaustion | Improved mobilization of the CD34(+) and CD133(+) bone marrow-derived circulating progenitor cells by freshly isolated intracoronary bone marrow cell transplantation in patients with ischemic heart disease. | 21190450 |
| Myocardial Ischemia | Stem Cell Exhaustion | Because the role of bone marrow-derived circulating progenitor cells (BM-CPCs) after cell therapy is less clear, we analyzed in this randomized, controlled study the influence of intracoronary autologous freshly isolated bone marrow cell transplantation (BMC-Tx) by using a point-of-care system on cardiac function and on the mobilization of BM-CPCs in patients with ischemic heart disease (IHD). | 21190450 |
| Hematologic Neoplasms | Stem Cell Exhaustion | The outcomes of family haploidentical hematopoietic stem cell transplantation in hematologic malignancies are not associated with patient age. | 21193055 |
| Disease, Bone marrow hypocellularity, MYELODYSPLASTIC SYNDROME, Cytopenia, Dysplasia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Myelodysplastic syndromes (MDSs) are clonal stem cell disorders characterized by cytopenias, dysplasia in one or more cell lineages and ineffective hematopoiesis and are associated with significant morbidity and mortality due to bone marrow failure or evolution to acute myeloid leukemia. | 21193364 |
| Ischemic | Stem Cell Exhaustion | The identification of factors that mobilize subsets of endogenous progenitor cells may provide new therapeutic tools to enhance the repair of ischaemic tissue. | 21193434 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Allogeneic stem cell transplantation is a potentially curative treatment for myelodysplastic syndromes. | 21195312 |
| Malignant Neoplasms | Stem Cell Exhaustion | During a 15 month period, altogether 63 patients with lymphoid malignancies were admitted to our department for blood stem cell collection. | 21198864 |
| Hematopoietic Stem Cell Mobilization | Stem Cell Exhaustion | Altogether 13/16 patients mobilized with a combination of chemomobilization and plerixafor received high-dose therapy with stem cell support and all engrafted. | 21198864 |
| Hematologic Neoplasms, Trauma, Diabetes Mellitus | Stem Cell Exhaustion | Underlying conditions included haematological malignancies (44%), trauma (15%), haematopoietic stem cell transplantation (9%) and diabetes mellitus (9%). | 21199154 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | In January 2005, an 18-year-old male patient with acute myeloid leukemia (AML) received a haploidentical hematopoietic stem cell transplantation (HSCT) from his father. | 21199355 |
| Multiple Myeloma | Stem Cell Exhaustion | Impairment in immunomodulatory function of mesenchymal stem cells from multiple myeloma patients. | 21199732 |
| Hemopoietic stem cell transplant, Acute lymphocytic leukemia | Stem Cell Exhaustion | A 35-year-old Caucasian man with a history of refractory acute lymphoblastic leukemia was admitted for a third allogeneic, mismatched, peripheral blood hematopoietic stem cell transplant from an unrelated donor, with a conditioning regimen that included busulfan and fludarabine. | 21200060 |
| Specialty Type - cancer | Stem Cell Exhaustion | Fetal-maternal microchimerism enhances the survival effect of interleukin-2-activated haploidentical peripheral blood stem cell treatment in patients with advanced solid cancer. | 21204769 |
| Specialty Type - cancer | Stem Cell Exhaustion | The goal of this study was to determine the clinical efficacy of KIR-ligand incompatibility and fetal-maternal microchimerism for interleukin-2-activated haploidentical peripheral blood stem cells (haplo-PBSCs) treatment for patients with advanced solid cancer. | 21204769 |
| Intrahepatic Cholangiocarcinoma, Hepatitis B, Communicable Diseases | Stem Cell Exhaustion | Recent efforts suggest an etiologic role of hepatitis B virus (HBV) infection in intrahepatic cholangiocarcinoma (ICC) and the involvement of hepatic progenitor cell in ICC development, without definitive conclusions. | 21207172 |
| Liver carcinoma, Liver Cirrhosis | Stem Cell Exhaustion | The independent association of HBV infection with ICC, synergy between cirrhosis and HBV infection, and some clinicopathological similarities between HBV-related ICC and hepatocellular carcinoma suggests that both may share similar or common tumorigenic process and may possibly originate from malignant transformation of hepatic progenitor cell. | 21207172 |
| Rheumatoid Arthritis | Stem Cell Exhaustion | In our case, it may be hypothesized that synchronous, heterogeneous mutations occurred in different type of committed cells or in stem cells, due to the production of cytokines by RA nodule histiocytes and lymphocytes, which are contiguous to the carcinomatous area. | 21210348 |
| Allogeneic Hematopoietic Stem Cell Transplantation, Chronic graft-versus-host disease | Stem Cell Exhaustion | Gene expression profile of cytokines in patients with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation with reduced conditioning. | 21211989 |
| Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | There are no reliable markers useful to predict the onset or the evolution of chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (HSCT), although several candidate biomarkers have been identified from limited hypothesis-driven studies. | 21211989 |
| Central neuroblastoma | Stem Cell Exhaustion | Stem-cell-supported chemotherapy is the current treatment of choice for high-stage, high-risk neuroblastoma, as in this case. | 21212023 |
| Thrombus, Myeloproliferative disease | Stem Cell Exhaustion | Endothelial progenitor cells are clonal and exhibit the JAK2(V617F) mutation in a subset of thrombotic patients with Ph-negative myeloproliferative neoplasms. | 21212285 |
| Malignant - descriptor, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Chronic myeloid leukemia (CML) is a clonal malignant disorder of a pluripotent hematopoietic stem cell characterized by the presence of a Philadelphia (Ph) chromosome. | 21212648 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Through a retrospective analysis, we investigated the efficacy of GVHD prophylaxis with rabbit anti-thymocyte globulin (ATG) 7.5 mg/kg (1 mg/kg given on day -3, then 3.25 mg/kg/day on days -2 and -1 before stem cell infusion) followed by standard tacrolimus plus methotrexate in a consecutive series of 45 HLA partially matched unrelated donor HCT recipients. | 21215811 |
| Neutropenia, Hematologic Neoplasms, Pichia kudriavzevii | Stem Cell Exhaustion | Candida krusei candidaemia was most commonly associated with haematological malignancy (61%; P < 0.001), stem cell transplantation (22%; P = 0.004), neutropenia (57%; P = 0.001) and prior use of antifungal azole agents (26%; P < 0.001). | 21216030 |
| Ischemia, diabetic, Ulcer | Stem Cell Exhaustion | Comparison of bone marrow mesenchymal stem cells with bone marrow-derived mononuclear cells for treatment of diabetic critical limb ischemia and foot ulcer: a double-blind, randomized, controlled trial. | 21216483 |
| CLU protein, human, diabetic, Ulcer | Stem Cell Exhaustion | Under ordinary treatment, the limbs of 41 type 2 diabetic patients with bilateral CLI and foot ulcer were injected intramuscularly with bone marrow mesenchymal stem cells (BMMSCs), bone marrow-derived mononuclear cells (BMMNCs), or normal saline (NS). | 21216483 |
| Exencephaly | Stem Cell Exhaustion | Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly. | 21220025 |
| Fanconi Anemia | Stem Cell Exhaustion | In the mid-1990s, we introduced a fludarabine (Flu)-based conditioning regimen for hematopoietic stem cell transplantation (HSCT) in patients with Fanconi anemia (FA).The aim of this study is to compare Flu-based conditioning to alternative regimens in patients with FA. | 21220033 |
| Multiple Myeloma | Stem Cell Exhaustion | Increased copy number of the interleukin-6 receptor gene is associated with adverse survival in multiple myeloma patients treated with autologous stem cell transplantation. | 21220034 |
| Myocardial Ischemia | Stem Cell Exhaustion | It has been questioned whether bone marrow-derived mesenchymal stromal cells (MSCs) from patients with ischemic heart disease are suitable for use in regenerative stem cell therapy. | 21222501 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | High dose chemotherapy followed by autologous stem cell transplantation (ASCT) is the preferred treatment modality for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). | 21223255 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | It was demonstrated previously that the STAT3 pathway maintains the tumorigenicity and therapeutic resistance of malignant tumors as well as cancer stem cells (CSCs). | 21225866 |
| Uremia | Stem Cell Exhaustion | In this study we evaluate the effect of uremia on LDL carbamylation and the effect of cLDL and oxidized LDL (oxLDL; 200 mg/ml) on number, function, and genomic stability of endothelial progenitor cells (EPCs) obtained from healthy volunteers. | 21228221 |
| Breast Carcinoma, Autoimmune Diseases, Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | The 13 cases studied included 5 bone marrow/stem cell transplantations, 3 solid organ transplantations, 1 autoimmune disease, 3 chronic lymphocytic leukemias, and 1 breast carcinoma. | 21228370 |
| Specialty Type - cancer | Stem Cell Exhaustion | CD133 is one of the most representative cancer stem cell markers. | 21228926 |
| Mucopolysaccharidosis I | Stem Cell Exhaustion | In seven patients, five with MPS I-H treated with stem cell transplantation (SCT), and two with MPS VI, one treated with SCT and the other with enzyme therapy, the IOP was examined with ORA. | 21232085 |
| Hemopoietic stem cell transplant, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Pre-transplant consolidation chemotherapy may not improve outcomes after reduced intensity conditioning hematopoietic stem cell transplantation for acute myeloid leukemia in first complete remission. | 21232793 |
| Hollings Cancer Center | Stem Cell Exhaustion | In particular, a stem cell marker EpCAM was dominantly expressed in CM-type HCC. | 21233610 |
| Specialty Type - cancer | Stem Cell Exhaustion | These were the cancer cell-, the microenvironment- and the stem cell-specific gene groups. | 21234521 |
| Liver carcinoma | Stem Cell Exhaustion | Immunohistochemical study of hepatocyte, cholangiocyte and stem cell markers of hepatocellular carcinoma. | 21234612 |
| Hollings Cancer Center | Stem Cell Exhaustion | At the same time, the expression of stem/progenitor cell markers and cholangiocyte markers may also indicate de-differentiation and transdifferentiation of ordinary HCC cells. | 21234612 |
| Hollings Cancer Center | Stem Cell Exhaustion | Sixty-eight surgically resected HCC lesions no larger than 5 cm were studied immunohistochemically using a hepatocyte marker (Hepatocyte), 2 cholangiocyte markers (cytokeratins CK7 and CK19), a marker for mucin (Muc1), and a hepatic stem/progenitor cell marker (C-kit). | 21234612 |
| Hollings Cancer Center | Stem Cell Exhaustion | The positivity of cholangiocyte markers, the stem/progenitor cell marker and mucin production were thought to be due to transdifferentiation of HCC cells rather than malignant transformation of stem/progenitor cells. | 21234612 |
| TG wt Allele | Stem Cell Exhaustion | Positive staining for bcl-2 and p63, and negative staining for PTH, CT, and TG in SCN main cells are both consistent with the widely accepted minimalist definition of stem cells, thus supporting the hypothesis that they may play a stem cell role in the thyroid gland, although further research will be required into stem cell markers. | 21234707 |
| insensitivity | Stem Cell Exhaustion | The impact of inflammatory mediators, EPO insensitivity, and other factors that may act on the hematopoietic stem cell to decrease erythropoiesis are under active study and should serve to elucidate the pathophysiology of this important cause of morbidity and mortality in elderly individuals. | 21239805 |
| Membranoproliferative Glomerulonephritis, Type II | Stem Cell Exhaustion | Marked improvement by high-dose chemotherapy and autologous stem cell transplantation in a case of light chain deposition disease. | 21240874 |
| Proteinuria | Stem Cell Exhaustion | Proteinuria disappeared and renal function stabilized after high-dose chemotherapy and autologous stem cell transplantation. | 21240874 |
| Membranoproliferative Glomerulonephritis, Type II | Stem Cell Exhaustion | It appears that an early initiation of active therapy such as high-dose chemotherapy and autologous stem cell transplantation may be beneficial for patients with light chain deposition disease. | 21240874 |
| Dyskeratosis Congenita | Stem Cell Exhaustion | Accelerated hematopoietic stem cell aging in a mouse model of dyskeratosis congenita responds to antioxidant treatment. | 21241452 |
| Ischemia | Stem Cell Exhaustion | Combination stem cell therapy for the treatment of medically refractory coronary ischemia: a Phase I study. | 21241969 |
| Ischemia | Stem Cell Exhaustion | Infusion of a source of endothelial progenitor cells (EPC) into the ischemic myocardium is emerging as a promising therapy for coronary ischemia, probably mediated by the formation of new blood vessels. | 21241969 |
| Congenital heart disease | Stem Cell Exhaustion | Characterization and functionality of cardiac progenitor cells in congenital heart patients. | 21242485 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | Pralatrexate induced durable responses in relapsed or refractory PTCL irrespective of age, histologic subtypes, amount of prior therapy, prior methotrexate, and prior autologous stem-cell transplant. | 21245435 |
| Age related macular degeneration | Stem Cell Exhaustion | SU5416 induces premature senescence in endothelial progenitor cells from patients with age-related macular degeneration. | 21245959 |
| Encephalitis, St. Louis, Calcification of coronary artery | Stem Cell Exhaustion | Circulating endothelial progenitor cells are reduced in SLE in the absence of coronary artery calcification. | 21246370 |
| Lupus Erythematosus, Systemic, Encephalitis, St. Louis | Stem Cell Exhaustion | Circulating endothelial progenitor cells (EPCs) are reduced in patients with systemic lupus erythematosus (SLE). | 21246370 |
| Esophageal Neoplasms | Stem Cell Exhaustion | To determine the relationship between resistance to chemotherapy and microRNA (miRNA) expression in esophageal cancer, we focused on miRNAs known to be associated with maintenance of stem cell function. | 21248297 |
| Esophageal Neoplasms | Stem Cell Exhaustion | Using 98 formalin-fixed, paraffin-embedded samples obtained from patients with esophageal cancer who had received preoperative chemotherapy followed by surgery, we measured expression levels of several miRNAs that are considered to be involved in the regulation of stem cell function (e.g., let-7a, let-7g, miR-21, miR-134, miR-145, miR-155, miR-200c, miR-203, and miR-296) by real-time reverse transcriptase PCR. | 21248297 |
| Dermatofibrosarcoma Protuberans, Cutaneous Fibrous Histiocytoma | Stem Cell Exhaustion | Expression of embryonic stem cell markers SOX2 and nestin in dermatofibrosarcoma protuberans and dermatofibroma. | 21251041 |
| Giant Cell Fibroblastoma | Stem Cell Exhaustion | Dermatofibrosarcoma protuberans (DFSP) was recently proposed to originate from a nestin-positive stem cell. | 21251041 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia. | 21251617 |
| T-Cell Lymphoma, Mycosis Fungoides and Sezary Syndrome | Stem Cell Exhaustion | A large single-center experience with allogeneic stem-cell transplantation for peripheral T-cell non-Hodgkin lymphoma and advanced mycosis fungoides/Sezary syndrome. | 21252059 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Effects of pioglitazone versus metformin on circulating endothelial microparticles and progenitor cells in patients with newly diagnosed type 2 diabetes--a randomized controlled trial. | 21255215 |
| Endothelium | Stem Cell Exhaustion | Endothelial microparticles (EMPs) and endothelial progenitor cells (EPCs) are markers of endothelial injury and repair. | 21255215 |
| Cerebrovascular accident | Stem Cell Exhaustion | Plasma VEGF, SDF-1a, granulocyte colony-stimulating factor, and stem cell factor were determined by enzyme-linked immunosorbent assay on days 1 and 3, and brain MRI was performed at baseline and on days 1 and 5 after the stroke onset. | 21257825 |
| Ischemic stroke | Stem Cell Exhaustion | These results indicate that SDF-1a and stem cell factor correlate with an increase in EPC early in ischemic stroke patients. | 21257825 |
| Cerebrovascular accident | Stem Cell Exhaustion | Stromal-derived factor-1[alpha] correlates with circulating endothelial progenitor cells and with acute lesion volume in stroke patients. | 21257825 |
| Chronic graft-versus-host disease | Stem Cell Exhaustion | Association between serum high-molecular-weight adiponectin level and the severity of chronic graft-versus-host disease in allogeneic stem cell transplantation recipients. | 21258011 |
| Intestinal Perforation, Lymphoproliferative Disorders | Stem Cell Exhaustion | [Epstein-Barr virus-associated post-transplant lymphoproliferative disorder diagnosed by the episode of intestinal perforation following allogeneic hematopoietic stem cell transplantation]. | 21258188 |
| Post-transplant lymphoproliferative disorder, Gastrointestinal perforation | Stem Cell Exhaustion | PTLD after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is relatively rare, and the development of gastrointestinal perforation after allo-HSCT is very rare. | 21258188 |
| Lymphoma | Stem Cell Exhaustion | We identified 496 consecutive individuals with lymphoma who underwent hematopoietic stem cell mobilization using etoposide and G-CSF and first autologous transplantation. | 21258422 |
| Malignant Hypertension, Hypertension, CTCAE | Stem Cell Exhaustion | We measured flow (hyperemia)-mediated dilation and response to glyceryl trinitrate of brachial artery (ultrasound), microvascular (forearm) response to acetylcholine and sodium nitroprusside (laser Doppler), pulse wave velocity, circulating endothelial and endothelial progenitor cells in 15 patients with malignant hypertension, 40 matched patients with hypertension, and 40 healthy controls. | 21263115 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft versus host disease (GVHD) represents one of the major limiting factors to the successful applicability of hematopoietic stem cells transplantation (HSCT). | 21264911 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | A modified EBMT risk score predicts the outcome of patients with acute myeloid leukemia receiving allogeneic stem cell transplants. | 21265883 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | To investigate the capacity of a modified European group for blood and marrow transplantation (mEBMT) risk score to predict the outcome of patients with acute myeloid leukemia (AML) receiving allogeneic stem cell transplants, we retrospectively analyzed 214 patients transplanted at our center between 1995 and 2008. | 21265883 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | Polymorphisms in prostate stem cell antigen gene rs2294008 increase gastric cancer risk in Chinese. | 21268123 |
| Ovarian Teratoma, Teratoma | Stem Cell Exhaustion | To understand the molecular mechanisms of ovarian teratoma growth, a comparative proteomic analysis was undertaken using mesenchymal stem cell-like cells (MSCLCs) isolated from normal human ovarian or teratoma tissues. | 21268265 |
| Glioblastoma | Stem Cell Exhaustion | The presence of stem cell marker-expressing cells is not prognostically significant in glioblastomas. | 21269333 |
| Adult Glioblastoma, Specialty Type - cancer | Stem Cell Exhaustion | To evaluate the prognostic implication of cancer stem cell markers in glioblastoma, the expression of these markers was investigated in a large series of glioblastoma patients in relation to the survival rate. | 21269333 |
| Glioblastoma Multiforme Pathway, Adult Glioblastoma | Stem Cell Exhaustion | Although the correlation of stem cell marker expression with clinical outcome in glioma is of considerable interest, the data do not support their prognostic value in glioblastoma. | 21269333 |
| Ischemic stroke | Stem Cell Exhaustion | Effect of erythropoietin on level of circulating endothelial progenitor cells and outcome in patients after acute ischemic stroke. | 21269484 |
| Ischemic stroke | Stem Cell Exhaustion | Erythropoietin (EPO) enhances the circulating level of endothelial progenitor cells (EPCs), which has been reported to be associated with prognostic outcome in ischemic stroke (IS) patients. | 21269484 |
| Colorectal Neoplasms | Stem Cell Exhaustion | Expression of LGR5, an intestinal stem cell marker, during each stage of colorectal tumorigenesis. | 21273608 |
| Glioma | Stem Cell Exhaustion | Recent studies suggest a possible origin of human gliomas from subventricular zone (SVZ) stem cells. | 21273932 |
| Myeloproliferative disease | Stem Cell Exhaustion | It is a chronic clonal myeloproliferative disorder, originating in a pluripotent stem cell common to all three hematopoietic lineages, characterized by overproduction of myeloid cells in all stages of maturation. | 21273957 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Treatment options for patients with high-risk acute myeloid leukemia (AML) include high-dose chemotherapy regimens in combination with allogeneic hematopoietic stem cell transplantation, which takes advantage of the donor T-cell-mediated graft-versus-leukemia effect. | 21274712 |
| Fanconi Anemia | Stem Cell Exhaustion | A 14-year-old girl with Fanconi anemia was submitted to allogeneic hematopoietic stem cell transplantation. | 21276065 |
| Breast Carcinoma | Stem Cell Exhaustion | Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma. | 21276239 |
| Postmenopausal state | Stem Cell Exhaustion | In this report, we show that the embryonic stem cell factor SOX2 is expressed in a variety of early stage postmenopausal breast carcinomas and metastatic lymph nodes. | 21276239 |
| Neoplasms | Stem Cell Exhaustion | Serum samples for PK or whole blood for the evaluation of circulating tumor cells, endothelial cells, and endothelial progenitor cells were obtained on Days 1, 8, 15, 29, and 50. | 21276608 |
| Hollings Cancer Center | Stem Cell Exhaustion | A decreased serum stem cell-derived factor-1 level 1 month after RT completion was a significant predictor of the overall survival of HCC patients receiving RT. | 21277098 |
| Aplastic Anemia, CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology | Stem Cell Exhaustion | Immunosuppressive therapy (IST) with anti-thymocyte globulin (ATG) plus cyclosporine A (CsA) is the standard treatment for aplastic anemia (AA) patients not eligible for allogeneic hematopoietic stem cell transplantation (HSCT). | 21279356 |
| Uveal melanoma, Stem Cell Factor | Stem Cell Exhaustion | To evaluate the concurrent rate of expression of c-Kit and its ligand stem cell factor (SCF) in uveal melanoma in respect to the further clinical course and the correlation of these markers. | 21279973 |
| Globoid cell leukodystrophy | Stem Cell Exhaustion | Mesenchymal lineage stem cells have pronounced anti-inflammatory effects in the twitcher mouse model of Krabbe's disease. | 21280158 |
| Inflammation | Stem Cell Exhaustion | These data indicate that mesenchymal lineage stem cells are potent inhibitors of inflammation associated with KD progression and offer potential benefits as a component of a combination approach for in vivo treatment by reducing the levels of inflammation. | 21280158 |
| Pterygium | Stem Cell Exhaustion | Ophthalmic pterygium: a stem cell disorder with premalignant features. | 21281814 |
| leukemia | Stem Cell Exhaustion | TRAIL-R3 expression was also high on CD34+/CD38- cells, the compartment that harbors the leukemia initiating stem cell. | 21281967 |
| Schistocyte | Stem Cell Exhaustion | Observation of schistocytes on the peripheral blood following haematopoietic stem cell transplantation (SCT) is a common finding. | 21284831 |
| Gastrointestinal Stromal Tumors, Mesenchymal Cell Neoplasm | Stem Cell Exhaustion | Gastrointestinal stromal tumors (GIST) are mesenchymal tumors of the gastrointestinal tract, usually kit-positive, that are believed to originate from interstitial cell of Cajal, or their related stem cells. | 21284869 |
| Lymphoma, Non-Hodgkin, Multiple Myeloma | Stem Cell Exhaustion | Several studies in adults have shown plerixafor to be effective for the mobilization of hematopoietic stem cells when used in combination with G-CSF in adults with non-Hodgkin's lymphoma and multiple myeloma who failed to mobilize sufficient CD34+ cells with G-CSF alone. | 21285407 |
| Myeloid | Stem Cell Exhaustion | Evi1 (ecotropic viral integration site 1) is essential for proliferation of hematopoietic stem cells and implicated in the development of myeloid disorders. | 21289308 |
| Chronic heart failure | Stem Cell Exhaustion | The effect of acute exercise on endothelial progenitor cells is attenuated in chronic heart failure. | 21290145 |
| Chronic heart failure, Congestive heart failure | Stem Cell Exhaustion | Exercise training improves endothelial function in patients with chronic heart failure (CHF) through functional enhancement of circulating angiogenic cells and increased numbers of circulating endothelial progenitor cells (EPC). | 21290145 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | The findings from this case have both diagnostic and biological implications that may inspire future studies on the pathogenic mechanisms by which cancer stem cells assume aberrant differentiation programs and the molecular switch(es) that initiates trophoblastic differentiation in adult tumor tissues. | 21293290 |
| Neoplasms, Secondary Neoplasm, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Stem Cell Exhaustion | MicroRNA-200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells. | 21294122 |
| Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Stem Cell Exhaustion | However, the role of miR200c in head and neck squamous cell carcinoma (HNSCC) and HNSCC-associated cancer stem cells (HNSCC-CSCs) is unknown. | 21294122 |
| Specialty Type - cancer | Stem Cell Exhaustion | This has the potential to be a powerful adjunct to stem-cell and cancer research. | 21294632 |
| Central neuroblastoma | Stem Cell Exhaustion | Patients were included when they fulfilled all of the following criteria: Age at diagnosis being 1 year or older, first diagnosis between 1990 and 2007, stage 4 disease or stage 3 neuroblastoma with MYCN amplification, and relapse or progression after successful first-line autologous stem cell transplantation (ASCT). | 21298742 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Nineteen patients had acute myeloid leukaemia and 47 had received high-dose chemotherapy supported by autologous stem cell transplant. | 21299364 |
| Pneumocystis jiroveci | Stem Cell Exhaustion | Pneumocystis jirovecii prophylaxis is standard in allogeneic stem cell transplantation (alloSCT), sometimes with pentamidine at a low dose inhaled monthly. | 21299635 |
| Russell-Silver syndrome | Stem Cell Exhaustion | Repeat SRS is promising to preserve neurocognition, because the convergent dose distribution decreases the unfavorable influences from radiation on germinal niches, thereby preserving neural stem cells that are responsible for the nervous system repair. | 21301184 |
| leukemia | Stem Cell Exhaustion | In this clonal disorder possibly involving a pluripotent hematopoietic stem cell, we postulate that the well documented relationships between PDGFRA downstream signals and intracellular ROS levels might influence the phenotype of this leukemia. | 21302907 |
| Malignant Neoplasms | Stem Cell Exhaustion | Common underlying conditions were hematopoietic stem cell and other transplantations (26.1%), malignancies (20.8%) and HIV (32.9%). | 21306282 |
| Childhood Breast Carcinoma, Neoplasms | Stem Cell Exhaustion | In this study, to explore putative breast cancer stem cells with CD44+CD24- in the SLN, we retrospectively analyzed the expression of CD44+CD24- on metastatic tumor cells within SLNs as a predictive factor for positive non-SLNs (NSLNs). | 21308353 |
| Deficiency | Stem Cell Exhaustion | Telomere shortening owing to telomerase deficiency leads to accelerated senescence of human skeletal (mesenchymal) stem cells (MSCs) in vitro, whereas overexpression leads to telomere elongation, extended life span, and enhanced bone formation. | 21308778 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | The risk factors for oral mucositis and the effect of cryotherapy in patients after the BEAM and HD-l-PAM 200 mg/m(2) autologous hematopoietic stem cell transplantation. | 21310656 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | Oral mucositis (OM) still represents a significant complication of hematopoietic stem cell transplantations (HSCT). | 21310656 |
| Multiple Myeloma | Stem Cell Exhaustion | Infusional mitoxantrone plus bolus melphalan as a stem cell transplant conditioning regimen for multiple myeloma. | 21314330 |
| Peripheral Blood Stem Cells, Mantle cell lymphoma | Stem Cell Exhaustion | To address whether treatment with hyper-CVAD impairs mobilization of peripheral blood stem cells, we retrospectively analyzed mobilization data from 77 consecutive adult patients with mantle cell lymphoma who underwent peripheral blood stem cell (PBSC) mobilization for planned autologous stem cell transplant (ASCT). | 21314484 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Treatment with hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone combined with cytarabine and methotrexate results in poor mobilization of peripheral blood stem cells in patients with mantle cell lymphoma. | 21314484 |
| Ovarian Carcinoma | Stem Cell Exhaustion | The objective of this study was to analyze the clinical role of nestin, a stem cell marker, and class III b-tubulin in advanced-stage serous ovarian carcinoma. | 21315408 |
| Injury of kidney | Stem Cell Exhaustion | Animal studies indicate that adult renal stem/progenitor cells can undergo rapid proliferation in response to renal injury, but whether the same is true in humans is largely unknown. | 21315412 |
| Acute Kidney Tubular Necrosis | Stem Cell Exhaustion | To examine the profile of renal stem/progenitor cells responsible for acute tubular necrosis in human kidney, double and triple immunostaining was performed using proliferative marker and stem/progenitor protein markers on sections from 10 kidneys with acute tubular necrosis and 4 normal adult kidneys. | 21315412 |
| Acute Kidney Tubular Necrosis | Stem Cell Exhaustion | Our data suggest that renal stem/progenitor cells may reside not only in the parietal layer of Bowman capsule but also in the cortex and medulla in normal human kidney, and the proliferative capacity of renal stem/progenitor cells after acute tubular necrosis may be an important determinant of a patient's outcome. | 21315412 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | The number of circulating CD34(+) (hematopoietic stem) cells (HSCs) was observed to decline by 15% in breast cancer patients after starting adjuvant radiation therapy, regardless of age or preceding chemotherapy. | 21316784 |
| Pancytopenia, Acquired aplastic anemia, Hematological Disease | Stem Cell Exhaustion | Acquired aplastic anemia is a rare hematopoietic stem-cell disorder that results in pancytopenia and hypocellular bone marrow. | 21319000 |
| Acquired aplastic anemia | Stem Cell Exhaustion | Acquired aplastic anemia can now be cured or ameliorated by stem-cell transplantation or immunosuppressive drug therapy such as antithymocyte globulin or cyclosporine. | 21319000 |
| Liver Cirrhosis | Stem Cell Exhaustion | Proliferating cell nuclear antigen (proliferation marker) and p21 (senescence marker) were both higher in hepatocytes in cirrhosis than in normal livers, but ductular reaction hepatobiliary cells had the highest proliferation rate, in keeping with being stem/progenitor cell-derived transit amplifying cells. | 21319194 |
| Hepatitis A, Hepatobiliary System | Stem Cell Exhaustion | These morphologic, topographic, immunophenotypic, and molecular data support the concept that EpCAM(+) hepatocytes in chronic viral hepatitis are recent progeny of the hepatobiliary stem/progenitor cell compartment through intermediates of the transit amplifying, ductular reaction hepatobiliary cells. | 21319194 |
| Lymphoma, Non-Hodgkin | Stem Cell Exhaustion | Allogeneic stem-cell transplantation as salvage therapy for patients with diffuse large B-cell non-Hodgkin's lymphoma relapsing after an autologous stem-cell transplantation: an analysis of the European Group for Blood and Marrow Transplantation Registry. | 21321299 |
| Lymphoma, Non-Hodgkin, Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | To analyze the outcome, including nonrelapse mortality (NRM), relapse rate (RR), progression-free survival (PFS), and overall survival (OS), of patients with diffuse large B-cell non-Hodgkin's lymphoma (DLBCL) relapsed after an autologous stem-cell transplantation (ASCT) and treated with an allogeneic stem-cell transplantation (allo-SCT). | 21321299 |
| palladium | Stem Cell Exhaustion | We have investigated the effects of commonly used treatments for PD on neural stem cell (NSC) activity in nondemented patients. | 21322018 |
| Neutropenia, Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Pegfilgrastim to accelerate neutrophil engraftment following peripheral blood stem cell transplant and reduce the duration of neutropenia, hospitalization, and use of intravenous antibiotics: a phase II study in multiple myeloma and lymphoma and comparison with filgrastim-treated matched controls. | 21323524 |
| Fusariosis, Endophthalmitis | Stem Cell Exhaustion | Endophthalmitis as primary clinical manifestation of fatal fusariosis in an allogeneic stem cell recipient. | 21324055 |
| Fever, Endophthalmitis, Myalgia | Stem Cell Exhaustion | Here, we report the case of a patient presenting with fever, muscle pain, and bilateral endophthalmitis after allogeneic hematopoietic stem cell transplantation. | 21324055 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Seroconversion rates following influenza vaccination in patients with hematologic malignancies after hematopoietic stem cell transplantation (HSCT) are known to be lower compared to healthy adults. | 21324375 |
| Dominica | Stem Cell Exhaustion | We aimed to investigate the cross-sectional association of Vit-D status with brachial flow-mediated dilation (FMD) and circulating endothelial progenitor cell (EPC) numbers in type 2 DM patients. | 21325459 |
| Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes. | 21325459 |
| Endothelial dysfunction, Deficiency | Stem Cell Exhaustion | The relationship of Vit-D deficiency with circulating endothelial progenitor cells and endothelial dysfunction in type 2 DM patients nonetheless remains unclear. | 21325459 |
| Heart failure | Stem Cell Exhaustion | Repeated intracoronary infusion of peripheral blood stem cells with G-CSF in patients with refractory ischemic heart failure--a pilot study. | 21325723 |
| Electrocardiogram: myocardial infarction (finding), Congestive heart failure | Stem Cell Exhaustion | Recent investigations have suggested the clinical efficacy of granulocyte colony-stimulating factor (G-CSF) infusion alone or in combination with a single dose delivery of peripheral blood stem cells (PBSC) infusion in patients with myocardial infarction (MI) and congestive heart failure (HF). | 21325723 |
| Hematologic Neoplasms, Herpesviridae Infections | Stem Cell Exhaustion | Herpesviridae viral infections (HVIs) are particularly common in patients with hematologic malignancies after undergoing hematopoietic stem cell transplantation or receiving chemotherapy. | 21325812 |
| Hemorrhagic cystitis | Stem Cell Exhaustion | BK-virus-associated hemorrhagic cystitis in children after hematopoietic stem cell transplantation. | 21325972 |
| Hemorrhagic cystitis | Stem Cell Exhaustion | BK-virus-induced hemorrhagic cystitis (BK-HC) is a serious complication in children undergoing hematopoietic stem cell transplantation (HSCT). | 21325972 |
| leukemia | Stem Cell Exhaustion | We conducted a retrospective study assessing the predictive value of early full donor chimerism status for relapse after allogeneic peripheral blood progenitor cell transplantation in 40 children aged between 1 and 16 years (median 8) with leukemia. | 21325973 |
| Neoplasms | Stem Cell Exhaustion | These cases demonstrate the capacity of tumor cells to differentiate into divergent elements, supporting the concept of pluripotent tumor stem cells. | 21326817 |
| Liver Cirrhosis | Stem Cell Exhaustion | Transplanted human amniotic membrane-derived mesenchymal stem cells ameliorate carbon tetrachloride-induced liver cirrhosis in mouse. | 21326862 |
| Fibrosis, Liver, Pulmonary Fibrosis | Stem Cell Exhaustion | Human amniotic membrane-derived mesenchymal stem cells (hAMCs) have the potential to reduce heart and lung fibrosis, but whether could reduce liver fibrosis remains largely unknown. | 21326862 |
| Tumor necrosis | Stem Cell Exhaustion | Human dermally-derived stem cells (FmSCs) were exposed to the cytokines interleukin-6 (IL-6), IL-1b, and tumor necrosis factor-a (TNF-a) in the presence of erythropoietin (EPO). | 21329452 |
| Cardiomyopathies | Stem Cell Exhaustion | Functionally competent cardiac stem cells can be isolated from endomyocardial biopsies of patients with advanced cardiomyopathies. | 21330601 |
| Malignant neoplasm of stomach, Specialty Type - cancer | Stem Cell Exhaustion | Recently, the CD44 molecule was reported to be a marker of cancer stem cells in gastric cancer. | 21331451 |
| Intimal proliferation | Stem Cell Exhaustion | Differentiation profile of peripheral blood-derived vascular progenitor cell predicts intimal hyperplasia after coronary stenting. | 21331618 |
| Liver carcinoma | Stem Cell Exhaustion | Elevated expression of the stem cell marker CD133 associated with Line-1 demethylation in hepatocellular carcinoma. | 21331808 |
| Liver carcinoma, Specialty Type - cancer, Hollings Cancer Center | Stem Cell Exhaustion | The relationship of Line-1 demethylation and the CD133 expression of cancer stem cells were discussed in hepatocellular carcinoma (HCC). | 21331808 |
| Hematologic Neoplasms | Stem Cell Exhaustion | A randomized clinical trial comparing granulocyte-colony-stimulating factor administration sites for mobilization of peripheral blood stem cells for patients with hematologic malignancies undergoing autologous stem cell transplantation. | 21332729 |
| Multiple Myeloma | Stem Cell Exhaustion | We completed a prospective randomized study to determine the efficacy and tolerability of different injection sites for patients with multiple myeloma or lymphoma undergoing stem cell mobilization and apheresis. | 21332729 |
| Specialty Type - cancer, Primary malignant neoplasm | Stem Cell Exhaustion | Primary breast cancer patients with high risk clinicopathologic features have high percentages of bone marrow epithelial cells with ALDH activity and CD44+CD24lo cancer stem cell phenotype. | 21334874 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cells (CSCs) are purported to be epithelial tumour cells expressing CD44(+)CD24(lo) that exhibit aldehyde dehydrogenase activity (Aldefluor(+)). | 21334874 |
| Multiple Myeloma | Stem Cell Exhaustion | Mobilization and collection of peripheral blood stem cells in multiple myeloma patients older than 65 years. | 21335198 |
| B-Cell Lymphomas, Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | This phase II trial evaluated the efficacy and safety of tandem consolidation using (90)yttrium ibritumomab tiuxetan ((90)Y-IT) and high-dose therapy (HDT) with autologous peripheral blood stem cell transplantation (PBSCT) in high-risk patients with diffuse large B-cell lymphoma (DLBCL) who were in primary remission. | 21336624 |
| Febrile Neutropenia, Infection, Acute leukemia | Stem Cell Exhaustion | Objective of the present study was to describe the profile of infections in febrile neutropenia (FN) in acute leukemia and hematopoietic stem cell transplant (HSCT) with emphasis on response to therapy and outcome. | 21336987 |
| Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | busulfan-fludarabine and allogeneic hematopoietic stem cell transplant for patients with acute myeloid leukemia or myelodysplastic syndrome in the sixth through eighth decades of life. | 21338705 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | b-catenin was found upregulated in the vast majority of AML samples and more frequently localized in the nucleus of leukemic stem cells compared with normal bone marrow CD34(+) cells. | 21339756 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Factors predicting outcome after unrelated donor stem cell transplantation in primary refractory acute myeloid leukaemia. | 21339758 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Some studies have shown that OCT4 is expressed in adult stem cells, somatic cancers and, further, cancer stem cells, while other studies failed to make such an observation. | 21341266 |
| Glioblastoma Multiforme Pathway, Breast Carcinoma, Solid Neoplasm, Specialty Type - cancer | Stem Cell Exhaustion | OCT4-pg1, OCT4-pg3 and OCT4-pg4 but excluding the OCT4 gene, were found to be expressed in two types of human solid tumours, glioma and breast carcinoma, from which cancer stem cells had earlier been isolated. | 21341266 |
| Malignant Neoplasms | Stem Cell Exhaustion | Hence, in investigations of OCT4 expression in cancers and stem cells, different approaches with appropriate controls would be desirable to exclude possibility of false-positive results. | 21341266 |
| Specialty Type - cancer, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Cancer stem cells (CSC) model theoretically contribute to tumor growth, metastasis, and chemo-radioresistance. | 21342274 |
| Bone marrow hypocellularity, Aplastic Anemia | Stem Cell Exhaustion | In addition, they suggest that human marrow failure, such as the marrow failure that occurs after umbilical cord blood transplantation and with aplastic anemia, results from insufficient numbers of early progenitor cells, and not the absence of HSCs. | 21343613 |
| Malignant Neoplasms | Stem Cell Exhaustion | They exhibited immunohistochemical features of hepatic progenitor cells, i.e., expressing CK7, CK19, and N-CAM; and their malignancy was supported by the p53 and Ki67 immunoreactivity. | 21344355 |
| Cholangiolocellular Carcinoma, Hepatitis B, Chronic, Liver carcinoma, Cholangiocarcinoma | Stem Cell Exhaustion | Cholangiolocellular carcinoma has been reported to be associated with chronic hepatitis C viral infection and to derive from hepatic progenitor cells, which explains why hepatocellular carcinoma and/or cholangiocarcinoma component may be present. | 21344355 |
| South Ndebele language | Stem Cell Exhaustion | Unfortunately the prognosis for patients within the high-risk group accounting for more than 50% of all NBL patients remains poor despite the introduction of more intensive chemotherapy regimens with radical surgery procedures and megachemotherapy with subsequent stem cell transplantation. | 21344767 |
| Acute monoblastic leukemia | Stem Cell Exhaustion | [Complete autologous bone marrow recovery after allogeneic stem cell transplantation in a child with acute monoblastic leukemia]. | 21344774 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We present a case of autologous bone marrow recovery after allogeneic hematopoietic stem cell transplantation (HSCT) in a 7-year old girl who was treated due to acute myelocytic leukemia. | 21344774 |
| Ki-1+ Anaplastic Large Cell Lymphoma | Stem Cell Exhaustion | Patient with ALCL was treated with chemotherapy and allogeneic stem cell transplantation. | 21344776 |
| Barrett Esophagus, Specialty Type - cancer, Adenocarcinoma Of Esophagus | Stem Cell Exhaustion | LgR5 expression and cancer stem cell hypothesis: clue to define the true origin of esophageal adenocarcinomas with and without Barrett's esophagus? | 21345220 |
| Barrett Esophagus, Specialty Type - cancer, Adenocarcinoma Of Esophagus | Stem Cell Exhaustion | Investigation of the expression of an intestinal stem cell marker in esophageal adenocarcinomas (EAC) with and without Barrett's Esophagus (BE), with respect to a cancer stem cell (CSC) hypothesis. | 21345220 |
| Extrapulmonary Small Cell Carcinoma, Adenocarcinoma, Squamous cell carcinoma of esophagus, Esophageal Neoplasms | Stem Cell Exhaustion | Expression of a putative intestinal stem cell marker LgR5 was analyzed in esophageal cancer specimen (n = 70: 41 EAC with BE, 19 EAC without BE, and n = 10 esophageal squamous-cell carcinomas, ESCC) and in the adenocarcinoma cell line OE-33. | 21345220 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | New data suggest that glioma stem-like cells (GSCs) and neural stem/progenitor cells (NSCs) may share common origins. | 21346220 |
| LMNA wt Allele | Stem Cell Exhaustion | Here we report the generation of induced pluripotent stem cells (iPSCs) from fibroblasts obtained from patients with HGPS. | 21346760 |
| Multiple Myeloma | Stem Cell Exhaustion | The place of allogeneic stem cell transplantation in the treatment of myeloma remains controversial. | 21349768 |
| EBV-Related Lymphoproliferative Disorder | Stem Cell Exhaustion | This single centre study assessed the incidence, kinetics and predictive factors of Epstein-Barr Virus (EBV) reactivation and EBV-related lymphoproliferative diseases (LPDs) in 175 consecutive patients who received a reduced-intensity conditioning (RIC) before allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 21350556 |
| Trichoepithelioma, Experimental Organism Basal Cell Carcinoma | Stem Cell Exhaustion | Follicular stem cell marker PHLDA1 (TDAG51) is superior to cytokeratin-20 in differentiating between trichoepithelioma and basal cell carcinoma in small biopsy specimens. | 21352265 |
| Specialty Type - cancer | Stem Cell Exhaustion | Additionally, we explored the function of Skp2 in maintaining a cancer stem cell-like phenotype in NPC cell lines. | 21352698 |
| Specialty Type - cancer | Stem Cell Exhaustion | Skp2 may play a role in maintaining the cancer stem cell-like phenotype of NPC cell lines. | 21352698 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | Impaired endothelial progenitor cell mobilization and colony-forming capacity in chronic obstructive pulmonary disease. | 21355963 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Using a case-control study with activity-based costing of patients admitted to a quaternary hospital from 2002 to 2007, we determined attributable hospitalization cost (and 12 weeks thereafter), length of stay (LOS), and costly antifungal treatment (C-AT; liposomal amphotericin B, voriconazole, posaconazole, caspofungin), expressed as defined daily doses (DDDs) per IFD episode, in patients with hematological malignancies and hematopoietic stem cell recipients. | 21357302 |
| Primary malignant neoplasm | Stem Cell Exhaustion | We explored the possible correlation between bone marrow mesenchymal stem cells (BM-MSC) and disseminated breast cancer-initiating cells (BCIC) in primary breast cancer patients. | 21358274 |
| Primary malignant neoplasm | Stem Cell Exhaustion | There was a positive correlation between mesenchymal stem cells expressing GD2 and CD271 and breast cancer-initiating cells in BM of patients with primary breast cancer. | 21358274 |
| Rhizomucor pusillus, Aplastic Anemia, Multiple Organ Failure | Stem Cell Exhaustion | Disseminated Rhizomucor pusillus causing early multiorgan failure during hematopoietic stem cell transplantation for severe aplastic anemia. | 21358340 |
| Aplastic Anemia | Stem Cell Exhaustion | Matched sibling donor hematopoietic stem cell transplantation is the standard of care for severe aplastic anemia, with an overall survival of 80% to 90%. | 21358340 |
| Aplastic Anemia, Multiple Organ Failure | Stem Cell Exhaustion | A 10-year-old patient with severe aplastic anemia underwent matched sibling donor hematopoietic stem cell transplantation, but developed sudden onset of fatal multiorgan failure on day +12. | 21358340 |
| Autoimmune Diseases, Aplastic Anemia | Stem Cell Exhaustion | High-dose cyclophosphamide without stem cell rescue in 207 patients with aplastic anemia and other autoimmune diseases. | 21358440 |
| Autoimmune Diseases, Aplastic Anemia | Stem Cell Exhaustion | High-dose cyclophosphamide has long been used as an anticancer agent, a conditioning regimen for hematopoietic stem cell transplantation, and a potent immunosuppressive agent in autoimmune diseases including aplastic anemia. | 21358440 |
| Autoimmune Diseases | Stem Cell Exhaustion | Moreover, high-dose cyclophosphamide without hematopoietic stem cell rescue has shown activity in a variety of other severe autoimmune diseases. | 21358440 |
| Autoimmune Diseases | Stem Cell Exhaustion | This latter component was designed to assess the safety and efficacy of high-dose cyclophosphamide therapy without stem cell rescue in patients with refractory autoimmune diseases. | 21358440 |
| Autoimmune Diseases | Stem Cell Exhaustion | High-dose cyclophosphamide without stem cell rescue is well tolerated and induces a high rate of remission in severe autoimmune diseases. | 21358440 |
| Lymphoma, Non-Hodgkin, Familial, Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | The significance of early lymphocyte recovery following a stem cell transplant in NHL subtype diffuse large B-cell lymphoma (DLBCL) in the rituximab era remains unclear. | 21358691 |
| Nasal sinus | Stem Cell Exhaustion | Retrospective analysis of paranasal sinusitis in patients receiving hematopoietic stem cell transplantation. | 21360008 |
| Nasal sinus, Opportunistic Infections | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (HSCT) recipients frequently develop opportunistic infections, including paranasal sinusitis. | 21360008 |
| diabetic | Stem Cell Exhaustion | Vasculogenic stem cell mobilization and wound recruitment in diabetic patients: increased cell number and intracellular regulatory protein content associated with hyperbaric oxygen therapy. | 21362081 |
| Leg Ulcer, Hypoxia, diabetic | Stem Cell Exhaustion | Diabetic patients undergoing hyperbaric oxygen therapies (HBO(2)T) for refractory lower extremity neuropathic ulcers exhibit more than a twofold elevation (p=0.004) in circulating stem cells after treatments and the post-HBO(2)T CD34(+) cell population contains two- to threefold higher levels of hypoxia inducible factors-1, -2, and -3, as well as thioredoxin-1 (p<0.003), than cells present in blood before HBO(2)T. Skin margins obtained from 2-day-old abdominal wounds exhibit higher expression of CD133, CD34, hypoxia inducible factor-1, and Trx-1 vs. margins from refractory lower extremity wounds and expression of these proteins in all wounds is increased due to HBO(2)T (p<0.003). | 21362081 |
| Neoplasms | Stem Cell Exhaustion | In conclusion, AITL is characterized by aggressive progress and generally occurs in elderly patients, its clinical prognosis is poor, the large granular lymphocytosis may be an autoimmune response to the tumor cells or originate from tumor stem/progenitor cells. | 21362234 |
| Ewings sarcoma, Pneumonia | Stem Cell Exhaustion | A 9-year-old and a 17-year-old male patients affected by metastatic Ewing sarcoma developed an organizing pneumonia after high-dose chemotherapy with autologous peripheral blood stem cell transplantation followed by total-lung irradiation. | 21364470 |
| Symptoms, Peripheral Stem Cell Transplantation, "Metastatic Ewings Sarcoma | Stem Cell Exhaustion | For this reason, even if rare, has to be considered in children affected by lung metastatic Ewing sarcoma with persisting pulmonary symptoms after peripheral blood stem cell transplantation and total-lung irradiation. | 21364470 |
| herpesvirus 3, human | Stem Cell Exhaustion | Significant risk factors for the development of herpes zoster were post-autologous peripheral blood stem cell transplantation, relapsing patients, ten or more total treatments and the use of two or more regimens. | 21368488 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Aldehyde dehydrogenase 1 (ALDH1) has been identified as a reliable marker of breast cancer stem cells. | 21371077 |
| Malignant Neoplasms | Stem Cell Exhaustion | Other common underlying conditions were hematopoietic stem cell transplantation (33.8%) and hematologic malignancy (29.1%). | 21378595 |
| Glioblastoma | Stem Cell Exhaustion | CSF samples from patients with glioblastoma multiforme show elevated Igf2 and stimulate stem cell proliferation in an Igf2-dependent manner. | 21382550 |
| Ischemia | Stem Cell Exhaustion | Parathyroid hormone (PTH) revealed a positive action on progenitor cells released from bone marrow, and many mechanisms supported PTH as a tool to improve stem cell-based therapy in experimental models of ischemia. | 21383630 |
| Uremia | Stem Cell Exhaustion | In the present study, we investigated, in a cohort of uremic patients, the effect of different levels of PTH on mobilization of progenitor cell populations. | 21383630 |
| Hyperparathyroidism | Stem Cell Exhaustion | After 4 months, we demonstrated an increase in endothelial progenitor cell number in 13 patients with secondary hyperparathyroidism that achieved KDOQI targets in PTH levels after pharmacological treatment. | 21383630 |
| Multiple Myeloma | Stem Cell Exhaustion | Successful treatment of early relapse of ocular myeloma with bortezomib and steroid after autologous stem cell transplantation. | 21384738 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Autologous stem cell transplantation (ASCT) can prolong remission duration, overall and progression free-survival in multiple myeloma (MM). | 21384738 |
| Toxic effect | Stem Cell Exhaustion | We evaluated the IVOx (ifosfamide-etoposide-oxaliplatin) salvage regimen in terms of response rate, toxicity and stem-cell mobilization. | 21385169 |
| LIPC gene | Stem Cell Exhaustion | IVOx is a well-tolerated outpatient regimen for relapsed HL, that does not hamper stem-cell mobilization, achieves good response rates and compares favourably with previously published salvage regimens. | 21385169 |
| Osteosarcoma, Specialty Type - cancer | Stem Cell Exhaustion | Human primary bone sarcomas contain CD133+ cancer stem cells displaying high tumorigenicity in vivo. | 21385990 |
| Specialty Type - cancer | Stem Cell Exhaustion | This study aimed to identify, isolate, and characterize cancer stem cells from human primary sarcomas. | 21385990 |
| Osteosarcoma, Specialty Type - cancer | Stem Cell Exhaustion | Our findings show the existence of cancer stem cells in human primary bone sarcomas and highlight CD133 as a pivotal marker for identification of these cells. | 21385990 |
| Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | Levels of circulating CD45(dim)CD34(+)VEGFR2(+) progenitor cells correlate with outcome in metastatic renal cell carcinoma patients treated with tyrosine kinase inhibitors. | 21386843 |
| Amyloidosis | Stem Cell Exhaustion | High-dose melphalan and autologous stem cell transplantation (HDM) is an effective treatment for systemic amyloid light chain (AL) amyloidosis but the eligibility criteria exclude many patients with this disorder. | 21387097 |
| malignant disease, PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Myelodysplastic syndrome (MDS) represents a heterogeneous group of potentially malignant diseases of bone-marrow stem cells. | 21387357 |
| Myocardial necrosis, Coronary Arteriosclerosis | Stem Cell Exhaustion | Are endothelial progenitor cells mobilized by myocardial ischemia or myocardial necrosis? | 21392766 |
| Electrocardiogram: myocardial infarction (finding), ST segment elevation myocardial infarction | Stem Cell Exhaustion | In ST-elevation myocardial infarction (STEMI) patients, the main stimuli involved in endothelial progenitor cells (EPCs) mobilization are not fully understood. | 21392766 |
| Myocardial, Myocardial necrosis, Coronary Arteriosclerosis | Stem Cell Exhaustion | Our data show that EPCs were strongly correlated to extent of myocardial AAR, thus suggesting that progenitor cells mobilization in STEMI develops in response to myocardial ischemia and not to myocardial necrosis. | 21392766 |
| Chronic graft-versus-host disease | Stem Cell Exhaustion | This trial evaluated the feasibility and efficacy of the infusion of mesenchymal stem cells expanded using human serum for the treatment of refractory acute or chronic graft-versus-host disease. | 21393326 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | In reduced intensity, allogeneic stem cell transplantation from unrelated donors (u-RIST), graft-versus-host disease (GVHD), graft failure, and non-relapse mortality (NRM) are persistent problems. | 21394567 |
| Glioblastoma, IDH-Wildtype, Specialty Type - cancer | Stem Cell Exhaustion | Both in U87MG cells and in primary glioblastoma cultures, the chronic administration of RV (100 mM for up to 96 h) decreased the expression of nestin (a brain (cancer) stem cells marker) but increased that of glial acidic fibrillary protein (a mature glial cell marker) and of bIII-tubulin (a neuronal differentiation marker). | 21395220 |
| Lymphoproliferative Disorders | Stem Cell Exhaustion | Isolated cerebral manifestation of Epstein-Barr virus-associated post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation: a case of clinical and diagnostic challenges. | 21395956 |
| Post-transplant lymphoproliferative disorder, Lymphoproliferative Disorders | Stem Cell Exhaustion | We present the case of a 49-year-old male patient with Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disorder (PTLD) limited to the brain that occurred 6 months after allogeneic hematopoietic stem cell transplantation (HSCT). | 21395956 |
| Sepsis, Renal Insufficiency | Stem Cell Exhaustion | The aim of the present study was to analyze the endothelial progenitor cell system in patients suffering from sepsis with acute renal dysfunction. | 21396100 |
| Sepsis | Stem Cell Exhaustion | Sepsis significantly affects the endothelial progenitor cell system, as reflected by increased EPC numbers, increased concentrations of proangiogenic mediators, and reduced proliferative capacity of the cells. | 21396100 |
| Sepsis, Renal Insufficiency | Stem Cell Exhaustion | Endothelial progenitor cells (EPC) in sepsis with acute renal dysfunction (ARD). | 21396100 |
| Specialty Type - cancer, Malignant neoplasm of stomach, Neoplasms | Stem Cell Exhaustion | In this case, the anastomosis site where a gastrectomy for gastric cancer was once performed might be a good niche or microenvironment for cancer cells or tumor stem cells to metastasize to. | 21396733 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Patients with hematological malignancies undergoing intensive chemotherapy or hematopoietic stem cell transplantation were randomized to two arms. | 21397541 |
| Keratitis | Stem Cell Exhaustion | Management of mustard gas-induced limbal stem cell deficiency and keratitis. | 21397949 |
| Ischemia, Dryness of eye | Stem Cell Exhaustion | The symptoms and clinical findings of patients are presented, and medical and surgical interventions to address dry eye, limbal ischemia and limbal stem cell deficiency (LSCD), and corneal involvements are explained. | 21397949 |
| Dilated Cardiomyopathy Pathway | Stem Cell Exhaustion | [Usefulness of intracoronary therapy with progenitor cells in patients with dilated cardiomyopathy: Bridge or alternative to heart transplantation?]. | 21398194 |
| Heart failure, Doctor of Chiropractic, Dilated Cardiomyopathy Pathway | Stem Cell Exhaustion | Some paediatric publications have recently raised the value of intracoronary therapy with autologous bone marrow-derived progenitor cells (APCs) in children with dilated cardiomyopathy (DCM) and heart failure. | 21398194 |
| Diabetes Mellitus, Non-Insulin-Dependent, GDC Disease Response Terminology, Vascular Diseases, Diabetic Retinopathy | Stem Cell Exhaustion | To investigate different types of circulating angiopoietic cells, such as vasculogenic circulating progenitor cells (CPCs), endothelial progenitor cells (EPCs), and mature EPCs (matEPCs) in patients with type 2 diabetes mellitus (T2DM), with or without diabetic retinopathy (DR) and with or without macrovascular disease (MVD). | 21398276 |
| Infection | Stem Cell Exhaustion | We recently showed that HIV enters multipotent hematopoietic progenitor cells and establishes both active cytotoxic and latent infections that can be reactivated by myeloid differentiation. | 21402361 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation overcomes the adverse prognostic impact of CD20 expression in acute lymphoblastic leukemia. | 21403127 |
| Diabetes | Stem Cell Exhaustion | Recently a considerable number of promising clinical trials have been designed to perform infusion of stem cells by pancreatic arterial intervention to improve the endocrine function of the pancreas for better diabetes control. | 21406019 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Autologous stem cell transplantation as a first-line treatment strategy for chronic lymphocytic leukemia: a multicenter, randomized, controlled trial from the SFGM-TC and GFLLC. | 21406717 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Long-term responses have been reported after autologous stem cell transplantation (ASCT) for chronic lymphocytic leukemia (CLL). | 21406717 |
| Infection | Stem Cell Exhaustion | Limited information is available from developing countries about complications, pattern of infections, and long-term outcome of patients following high-dose chemotherapy (HDCT) and autologous blood stem cell transplantation (ASCT). | 21409382 |
| Hemangiosarcoma | Stem Cell Exhaustion | Our study aimed to examine the correlations between 6 immunohistochemical biomarkers-stem cell factor receptor (KIT), platelet-derived growth factor receptor (PDGFR)-a, PDGFR-b, vascular endothelial growth factor receptor (VEGFR)-1, VEGFR-2, and VEGFR-3-and overall survival (OS) in patients with angiosarcomas. | 21409488 |
| Hodgkin Disease | Stem Cell Exhaustion | Autologous stem cell transplant for early relapsed/refractory Hodgkin lymphoma: results from two transplant centres. | 21410449 |
| Multiple Myeloma | Stem Cell Exhaustion | Haematopoietic stem cell mobilization with plerixafor and G-CSF in patients with multiple myeloma transplanted with autologous stem cells. | 21410533 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | A proportion of patients with multiple myeloma (MM) who have already undergone autologous stem cell transplantation (autoSCT) might benefit from a further transplantation. | 21410533 |
| macroangiopathy, Diabetes, Corneal Endothelial Cell Loss | Stem Cell Exhaustion | In diabetes, endothelial damage promotes macroangiopathy and endothelial regeneration is impaired, owing to reduced endothelial progenitor cells (EPCs). | 21410861 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | We report the successful use of the Genous endothelial progenitor cell (EPC) capture stent in two patients requiring PCI for significant coronary artery disease prior to lung resection. | 21411333 |
| Glioma, Neoplasms | Stem Cell Exhaustion | The putative tumor stem cell marker CD133 is the marker of choice for identifying brain tumor stem cells in gliomas, but the use of different CD133 antibody clones possibly recognizing different CD133 splice variants with epitopes of different glycosylation status confuses the field. | 21411810 |
| Influenza due to Influenza A virus subtype H1N1 | Stem Cell Exhaustion | Data derived from epidemiologic surveillance adopted at our center in hematologic and stem cell transplant patients during the 2009 influenza A (H1N1)v pandemic are reported. | 21411983 |
| Necrosis | Stem Cell Exhaustion | Trials have brought diverse results of bone marrow stem cell treatment in necrotic myocardium. | 21414223 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | This substudy from the Autologous Stem Cell Transplantation in Acute Myocardial Infarction trial (ASTAMI) explored global and regional myocardial function after intracoronary injection of autologous mononuclear bone marrow cells (mBMC) in acute anterior wall myocardial infarction treated with percutaneous coronary intervention. | 21414223 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | Maribavir prophylaxis for prevention of cytomegalovirus disease in recipients of allogeneic stem-cell transplants: a phase 3, double-blind, placebo-controlled, randomised trial. | 21414843 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | Cytomegalovirus disease as a primary endpoint might not be sufficient to show improvements in cytomegalovirus prevention in recipients of allogeneic stem-cell transplants in the setting of pre-emptive antiviral treatment. | 21414843 |
| Ischemic cardiomyopathy | Stem Cell Exhaustion | Intramyocardial stem cell injection in patients with ischemic cardiomyopathy: functional recovery and reverse remodeling. | 21415390 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | We used cardiac MRI (CMR) in patients with left ventricular (LV) dysfunction related to remote myocardial infarction (MI) to test the hypothesis that bone marrow progenitor cell injection causes functional recovery of scarred myocardium and reverse remodeling. | 21415390 |
| Myocardial | Stem Cell Exhaustion | These data suggest that transcatheter, intramyocardial injections of autologous bone marrow progenitor cells improve regional contractility of a chronic myocardial scar, and these changes predict subsequent reverse remodeling. | 21415390 |
| Neoplasms | Stem Cell Exhaustion | It is hypothesized that composite tumors arise from a multipotential stem cell with subsequent bidirectional differentiation. | 21419473 |
| Neoplasms | Stem Cell Exhaustion | The concordant E-cadherin status in the neuroendocrine and signet ring cell tumor components and the frequent admixture of mucin 5AC+ cells with foveolar differentiation and mucin 2+ cells with intestinal differentiation may support the hypothesis that composite tumors arise from a common stem cell with bilineage or multilineage differentiation. | 21419473 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease is the major determinant of humoral responses to the AS03-adjuvanted influenza A/09/H1N1 vaccine in allogeneic hematopoietic stem cell transplant recipients. | 21422117 |
| Graft-vs-Host Disease, Gastrointestinal mucositis | Stem Cell Exhaustion | Efficacy of folinic acid in preventing oral mucositis in allogeneic hematopoietic stem cell transplant patients receiving MTX as prophylaxis for GVHD. | 21423118 |
| Adult Glioblastoma | Stem Cell Exhaustion | Cancer-initiating or progenitor cells have been described to be the only cell population with tumorigenic capacity in glioblastoma. | 21423202 |
| Pterygium | Stem Cell Exhaustion | Recent studies linked pterygium with neoplastic proliferation, as ocular limbic stem cells and p53-protein expression are altered. | 21424047 |
| Bronchiolitis Obliterans | Stem Cell Exhaustion | Incidence, risk factors and outcomes of bronchiolitis obliterans after allogeneic stem cell transplantation. | 21424350 |
| Bronchiolitis Obliterans, Respiratory complication, bottle - unit dose, Late Onset Disorders | Stem Cell Exhaustion | Bronchiolitis obliterans (BO) after allogeneic stem cell transplantation (allo-SCT) is a late-onset, life-threatening respiratory complication that significantly reduces a patient's quality of life. | 21424350 |
| Trilateral Retinoblastoma | Stem Cell Exhaustion | High-dose chemotherapy followed by autologous and allogeneic peripheral blood stem cell transplantation for recurrent disseminated trilateral retinoblastoma. | 21424400 |
| Neoplasms | Stem Cell Exhaustion | The disseminated tumor disappeared after the first autologous peripheral blood stem cell transplantation (PBSCT) with high-dose melphalan and thiotepa. | 21424400 |
| Specialty Type - cancer, Neoplasms, Intracranial | Stem Cell Exhaustion | The cancer stem cell potential of TG20 cells was confirmed based on their expression of neural stem cell markers, their capacity of in vitro long-term proliferation and to form intracranial tumors in immune-deficient mice. | 21425407 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Alternative lengthening of telomeres in human glioma stem cells. | 21425407 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells are increasingly recognized as major therapeutic targets. | 21425407 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | We report here the isolation of glioma stem cells (GSCs) maintaining telomere length through a telomerase-independent mechanism known as alternative lengthening of telomeres (ALTs). | 21425407 |
| Specialty Type - cancer | Stem Cell Exhaustion | Therefore, our data show for the first time that the ALT pathway can confer to cancer stem cells the capacity to sustain long-term proliferation as telomerase activity and importantly may also affect treatment efficiency. | 21425407 |
| Neutropenia, Asthenia, Venous Thromboembolism, Toxic effect, Abnormal digestive tract function, Atrial Fibrillation by ECG Finding, Myelosuppression, skin toxicity | Stem Cell Exhaustion | The major adverse events (AEs) associated with lenalidomide include: hematological toxicities (myelosuppression), mainly neutropenia, venous thromboembolism, gastrointestinal disturbance, skin toxicity, atrial fibrillation, asthenia, and decreased peripheral blood stem cell yield during stem cell collection when lenalidomide is used after a long period of time. | 21431627 |
| Gain, Loss | Stem Cell Exhaustion | Of note, the loss and gain of this capacity to differentiate coincided with the loss and gain of a subpopulation within the CD34(+) proliferative compartment with surface expression of the stem cell factor receptor (SCF-R/CD117/c-Kit). | 21431918 |
| Drug-induced | Stem Cell Exhaustion | In order to achieve high telomerase activity as detected in hematological stem cells, precursor cells from the acute-myeloid leukemia (AML)-derived cell line MUTZ3 were stably transduced with human telomerase reverse transcriptase (hTERT) to facilitate their growth potential, while preventing growth, and drug-induced senescence, and preserving their unique capacity for cytokine-dependent DC and LC differentiation. | 21431918 |
| Teratoma | Stem Cell Exhaustion | In particular, we found that these cells share the following features with ES: (i) high levels of embryonic stem cell markers (CD90, TRA1-60, TRA1-81, OCT-4, CD133, and SSEA-4); (ii) mRNA transcripts for Nanog and Rex-1; (iii) broader potency, being able to differentiate in cell types of all three germ layer, including smooth and skeletal muscle, osteoblasts, neurons, glial cells, and adipocytes; (iv) high levels of telomerase activity; (v) ability to form embryoid bodies; (vi) ability, after injection in murine blastocysts, to be localised within the inner cell mass; (vii) no teratoma formation after injection; (viii) in vivo tissue formation after transplantation. | 21432784 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Acute myeloid leukemia (AML) is a heterogeneous clonal disorder of hematopoietic progenitor cells that presents genetic abnormalities in several genes, including NPM. | 21434520 |
| Hematological Disease | Stem Cell Exhaustion | This work aims at assessing and describing the most frequent clinical manifestations of the Graft-versus- Host Disease (GvHD) in the oral and maxillofacial region in paediatric patients affected by neoplastic or non neoplastic haematologic disorders who undergo specific haematopoietic stem cell transplantation (HSCT) protocols, with a view to detecting the potential pathological modifications that are recognised as the cause of a possible altered harmonious development of the child. | 21434736 |
| Hematological Disease | Stem Cell Exhaustion | Thirty-eight paediatric patients aged between 3 and 13 years, coming from the haematological department of Tor Vergata University (Roma, Italy) and affected by GvHD, assessed on the basis of their medical history and accurate clinical and instrumental exams, after having received haematopoietic stem cell transplantation for neoplastic or non neoplastic haematologic disorders, were enrolled in this study. | 21434736 |
| Neoplasms | Stem Cell Exhaustion | In conclusion, human gastric cancer cell lines enclose a phenotypically and genotypically distinct cell population with tumor stem cell features. | 21435459 |
| Neoplasms | Stem Cell Exhaustion | The side population (SP) of tumor cell lines shares characteristics with tumor stem cells. | 21435459 |
| Neoplasms | Stem Cell Exhaustion | The p53 tumor suppressor has been shown to negatively regulate the activity of the Shh effector, Gli1, in neural stem cells; however, the contribution of p53 to the regulation of Shh signaling in GNPs during cerebellar development has not been determined. | 21437245 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Nineteen patients received therapy for acute myeloid leukemia, and 50 patients were autologous stem cell transplantation recipients. | 21437589 |
| Angiolymphoid hyperplasia | Stem Cell Exhaustion | Autologous stem cell transplantation in a rare multicentric Castleman disease of the plasma cell variant. | 21437636 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Spontaneous autologous graft-versus-host disease in plasma cell myeloma autograft recipients: flow cytometric analysis of hematopoietic progenitor cell grafts. | 21440080 |
| Multiple Myeloma | Stem Cell Exhaustion | Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients. | 21440298 |
| Specialty Type - cancer, Neoplasms, Malignant Neoplasms | Stem Cell Exhaustion | Its expression might be a suitable diagnostic and prognostic indicator of malignancy and a potential marker of cancer stem cells in solid tumors. | 21440298 |
| Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0 | Stem Cell Exhaustion | The deficiency of glycosyl-phosphatidylinositol (GPI)-anchored proteins in plasma membranes of PIG-A gene mutated hematopoietic stem cells (HSCs) is so far insufficient to explain the domination of paroxysmal nocturnal hemoglobinuria (PNH) clone over the normal HSC. | 21442308 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | In this first case-series of 6 stem cell transplant recipients who received preemptive artesunate treatment for CMV infection, we have examined the viral kinetics following institution of artesunate, and employed first-phase viral kinetics studies to calculate its antiviral effectiveness. | 21443904 |
| Lymphopenia, Unknown (origin) (qualifier value) | Stem Cell Exhaustion | Non-myeloablative hematopoietic stem cell transplantation in the treatment of severe idiopathic CD4+ lymphocytopenia. | 21447008 |
| Lymphopenia, Opportunistic Infections | Stem Cell Exhaustion | A 40-year-old man with severe chronic idiopathic CD4+ lymphocytopenia complicated with opportunistic infections was successfully treated with non-myeloablative allogeneic hematopoietic stem cell transplantation. | 21447008 |
| Lymphopenia | Stem Cell Exhaustion | Non-myeloablative allogeneic hematopoietic stem cell transplantation should be considered a treatment option for patients with severe forms of idiopathic CD4+ lymphocytopenia. | 21447008 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | To examine mitochondrial gene expression in hematopoietic progenitor cells of patients with myelodysplastic syndromes (MDS). | 21447369 |
| Malignant neoplasm of stomach, Specialty Type - cancer | Stem Cell Exhaustion | Cancer spheres from gastric cancer patients provide an ideal model system for cancer stem cell research. | 21448722 |
| Specialty Type - cancer | Stem Cell Exhaustion | Interestingly, a single cancer stem cell generated a cancer sphere that contained various differentiated cells, supporting multi-potency and self-renewal of a cancer stem cell. | 21448722 |
| Malignant neoplasm of stomach, Specialty Type - cancer | Stem Cell Exhaustion | The above in vivo and in vitro results suggest that cancer stem cells, which are enriched in the EpCAM(+)/CD44(+) subpopulation of gastric cancer cells, provide an ideal model system for cancer stem cell research. | 21448722 |
| Specialty Type - cancer, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Cancer stem cells have been hypothesized to drive the growth and metastasis of tumors. | 21448722 |
| Specialty Type - cancer, Primary malignant neoplasm | Stem Cell Exhaustion | However, cancer stem cells from primary human gastric cancer tissues have not been isolated as yet. | 21448722 |
| Cardiovascular Diseases | Stem Cell Exhaustion | Dietary intake of phytoestrogen is associated with increased circulating endothelial progenitor cells in patients with cardiovascular disease. | 21450646 |
| CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology | Stem Cell Exhaustion | Eight patients (8.9%) underwent haematopoietic stem cell transplantation (HSCT), 12 (13.3%) received immunosuppressive therapy (IST) and 70 patients (77.7%) received other and supportive therapy. | 21453618 |
| PAFAH1B1 wt Allele, Bone marrow hypocellularity | Stem Cell Exhaustion | In MDS, activated T cells are thought to mediate bone marrow failure via overproduction of proinflammatory cytokines that cause stem cell apoptosis. | 21454192 |
| Waldenstrom Macroglobulinemia | Stem Cell Exhaustion | Autologous stem cell transplantation as a care option in Waldenstrom's macroglobulinemia. | 21454216 |
| Malignant Neoplasms | Stem Cell Exhaustion | Pandemic 2009 H1N1 influenza in patients with hematopoietic stem cell transplantation and hematologic malignancy: single center experience. | 21455013 |
| H1N1 | Stem Cell Exhaustion | In this study, we present the results of active H1N1 surveillance in 32 patients who were treated at our hematology/stem cell transplantation clinic between December 2009 and January 2010. | 21455013 |
| Influenza due to Influenza A virus subtype H1N1 | Stem Cell Exhaustion | Eight patients in the hematology clinic and 7 patients in the hematology/stem cell transplantation unit tested positive for pandemic H1N1 infection. | 21455013 |
| Impaired | Stem Cell Exhaustion | Clinical impact of pre-transplant pulmonary impairment on survival after allogeneic hematopoietic stem cell transplantation. | 21455634 |
| Impaired | Stem Cell Exhaustion | We retrospectively analyzed the clinical outcomes of patients with pulmonary impairment before undergoing allogeneic hematopoietic stem cell transplantation (HSCT) for the first time. | 21455634 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Nonmyeloablative allogeneic stem cell transplantation in relapsed/refractory chronic lymphocytic leukemia: long-term follow-up, prognostic factors, and effect of human leukocyte histocompatibility antigen subtype on outcome. | 21455998 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | The role of nonmyeloablative allogeneic stem cell transplantation (NST) in the treatment of chronic lymphocytic leukemia (CLL) is not well established. | 21455998 |
| Uterine Fibroids, Lipoma | Stem Cell Exhaustion | To understand the HMGA2-p14(Arf) -relationship in benign tumorigenesis, we performed a series of experiments on mesenchymal stem-cells, i.e., the proposed cells of origin of lipomas and uterine leiomyomas. | 21456046 |
| leukemia | Stem Cell Exhaustion | Ex vivo purging is an emerging technique for successful transplantation of autologous hematopoietic stem cells in the treatment of leukemia. | 21457188 |
| Alzheimers Disease | Stem Cell Exhaustion | If microglia telomere damage is causing Alzheimer's disease, self-donated bone marrow or dental pulp stem cell transplants could give rise to new microglia populations that would maintain neuronal health while the original resident microglia population died. | 21458164 |
| methyldopa | Stem Cell Exhaustion | To compare RPE derived from human embryonic stem cells (hES-RPE) and fetal RPE (fRPE) behavior on human Bruch's membrane (BM) from aged and AMD donors. | 21460262 |
| Multiple Myeloma | Stem Cell Exhaustion | Age at transplantation and outcome after autologous stem cell transplantation in elderly patients with multiple myeloma. | 21460604 |
| Trauma | Stem Cell Exhaustion | The study is designed to investigate the endothelial progenitor cell mobilization after injury and a potential use of circulating endothelial progenitor cells as a prognostic marker for evaluating trauma severity and clinical outcomes. | 21460712 |
| Traumatic | Stem Cell Exhaustion | Endothelial progenitor cells correlate with clinical outcome of traumatic brain injury. | 21460712 |
| Traumatic | Stem Cell Exhaustion | Endothelial progenitor cells play an active role in vascular repair and revascularization of tissue damaged by traumatic, inflammatory, and ischemic injures. | 21460712 |
| Traumatic | Stem Cell Exhaustion | We correlate the changes in circulating endothelial progenitor cells with the severity of traumatic brain injury. | 21460712 |
| Traumatic | Stem Cell Exhaustion | Changes in the levels of circulating endothelial progenitor cells were monitored for up to 21 days in 84 patients with traumatic brain injury. | 21460712 |
| Trauma | Stem Cell Exhaustion | Circulating endothelial progenitor cells in patients with improved Glasgow Coma Scale scores were significantly higher than those with deteriorated conditions and remained persistently low in patients who died of trauma. | 21460712 |
| Traumatic | Stem Cell Exhaustion | The results suggest that the level of circulating endothelial progenitor cells correlates with the clinical severity and outcome of traumatic brain injury and may offer potential as a prognostic marker for traumatic brain injury. | 21460712 |
| Intraepithelial Neoplasia, Squamous cell carcinoma | Stem Cell Exhaustion | Oral epithelial dysplasia and squamous cell carcinoma following allogeneic hematopoietic stem cell transplantation: clinical presentation and treatment outcomes. | 21460866 |
| Neoplasm Metastasis | Stem Cell Exhaustion | Late complications of allogeneic hematopoietic stem cell transplantation (HSCT) include a risk of secondary malignancies. | 21460866 |
| Therapy-related myelodysplastic syndrome | Stem Cell Exhaustion | The use of etoposide (VP-16) for stem cell mobilization has been reported as a significant risk factor for the development of therapy-related myelodysplasia/therapy-related AML (tMDS/tAML) after transplantation. | 21460870 |
| Lymphoma | Stem Cell Exhaustion | An XRCC1 polymorphism is associated with the outcome of patients with lymphoma undergoing autologous stem cell transplant. | 21463129 |
| Lymphoma | Stem Cell Exhaustion | High-dose chemotherapy supported by autologous stem cell transplant (ASCT) remains the treatment of choice for patients with lymphoma failing first-line chemotherapy. | 21463129 |
| Angina Pectoris, Acute myocardial infarction | Stem Cell Exhaustion | Circulating CD34+ progenitor cells and growth factors in patients treated with PCI for acute myocardial infarction or stable angina pectoris. | 21463159 |
| Hepatitis B, Malignant neoplasm of liver | Stem Cell Exhaustion | Does the hepatitis B antigen HBx promote the appearance of liver cancer stem cells? | 21464043 |
| Hollings Cancer Center | Stem Cell Exhaustion | HBV-encoded X antigen, HBx, and pathways implicated in the self-renewal of stem cells contribute to HCC, but it is not clear whether HBx expression promotes "stemness." | 21464043 |
| Specialty Type - cancer | Stem Cell Exhaustion | Thus, experiments were designed to test the hypothesis that HBx triggers malignant transformation by promoting properties that are characteristic of cancer stem cells (CSC). | 21464043 |
| Heart failure, Hypokinesia | Stem Cell Exhaustion | While hematopoietic stem cell transplantation was being planned, progressive cardiac failure developed with a striking hypokinesia of the left-ventricle free wall. | 21464194 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Impact of immune modulation with anti-T-cell antibodies on the outcome of reduced-intensity allogeneic hematopoietic stem cell transplantation for hematologic malignancies. | 21464372 |
| Pterygium | Stem Cell Exhaustion | Because ultraviolet exposure is a risk factor for development and growth of pterygium, 1 possible explanation for this patient's findings is the effect of the excimer laser (which has a wavelength in the ultraviolet spectrum) on a previously insignificant corneal growth and/or the corneal limbal stem cells. | 21464701 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Thus, our findings suggest that MMF is safe and effective for the prevention and treatment of GVHD in patients who have received an allogeneic stem cell transplant. | 21465117 |
| Specialty Type - cancer, Neoplasms, Carcinogenesis | Stem Cell Exhaustion | Cancer testis (CT) antigens are potential candidates because their expression is restricted to tumors, and accumulating data suggest that they play important roles in cellular proliferation, stem cell function, and carcinogenesis. | 21465317 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Autologous stem-cell transplantation in patients with mantle cell lymphoma beyond 65 years of age: a study from the European Group for Blood and Marrow Transplantation (EBMT). | 21467125 |
| Medial collateral ligament, Mantle cell lymphoma | Stem Cell Exhaustion | Limited experience is available on the feasibility and efficacy of autologous stem-cell transplantation (ASCT) in patients with mantle cell lymphoma (MCL) beyond 65 years. | 21467125 |
| Fibrosis Assessment | Stem Cell Exhaustion | The thickness of myofibroblast layers increased towards Group 4 without cell proliferation, but CD34(+) cells, marking cells of haematopoetic lineage and progenitor cells (in lung fibrosis), were found in close proximity to tubules. | 21467201 |
| Tetraploidy | Stem Cell Exhaustion | The clinical course of this case suggests that hematopoietic stem cell transplantation during the first CR phase should be considered a treatment option for tetraploid AML. | 21471699 |
| HIV-Associated Lymphoproliferative Disorder | Stem Cell Exhaustion | [EBV-associated B-cell lymphoproliferative disorder of the elderly successfully treated with autologous peripheral blood stem cell transplantation and locoregional radiotherapy]. | 21471700 |
| HIV-Associated Lymphoproliferative Disorder | Stem Cell Exhaustion | This is the first report of successful autologous stem cell transplantation for a patient with age-related EBV-associated B-cell lymphoproliferative disorder. | 21471700 |
| Multiple Myeloma | Stem Cell Exhaustion | [Bortezomib plus dexamethasone treatment followed by reduced-intensity allogeneic stem cell transplantation for multiple myeloma refractory to high-dose chemotherapy with autologous transplantation]. | 21471701 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | We present two long-term survivors after allogeneic transplantation with reduced-intensity conditioning regimen following relapse after autologous stem cell transplantation (ASCT) for multiple myeloma (MM). | 21471701 |
| Dryness of eye | Stem Cell Exhaustion | Donor-recipient gender difference affects severity of dry eye after hematopoietic stem cell transplantation. | 21475315 |
| Dryness of eye | Stem Cell Exhaustion | To determine whether the incidence rate and severity of dry eye after hematopoietic stem cell transplantation varies with donor vs recipient gender. | 21475315 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | In the univariable analyses of the influence of pre-transplant variables on OS, poor-risk cytogenetics, number of BM blasts (>26%), MDS overt AML and CB as stem cell source were significantly associated with worse prognosis (p = .03, p = .01, p = .02 and p < .001, respectively). | 21477348 |
| Immunologic Deficiency Syndromes | Stem Cell Exhaustion | In vivo T-cell dynamics during immune reconstitution after hematopoietic stem cell gene therapy in adenosine deaminase severe combined immune deficiency. | 21477850 |
| Immunologic Deficiency Syndromes | Stem Cell Exhaustion | Gene therapy (GT) with hematopoietic stem cells is a promising treatment for inherited immunodeficiencies. | 21477850 |
| Malignant neoplasm of brain, Adult Glioblastoma | Stem Cell Exhaustion | The CD133 antigen has been described as a putative stem cell marker in malignant brain tumor that could identify such a tumorigenic population in a subset of glioblastoma. | 21479688 |
| Adult Glioblastoma | Stem Cell Exhaustion | The quantitative expression of CD133 stem cell antigen mRNA using real-time QRT-PCR was assessed in a cohort of 48 consecutive primary glioblastoma patients treated by chemoradiation with temozolomide. | 21479688 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cells are thought to represent the population of tumorigenic cells responsible for tumor development. | 21479688 |
| Aneurysm | Stem Cell Exhaustion | Presence of circulating endothelial progenitor cells and levels of stromal-derived factor-1a are associated with ascending aorta aneurysm size. | 21481600 |
| Peripheral Arterial Diseases | Stem Cell Exhaustion | Exercise training increases endothelial progenitor cells and decreases asymmetric dimethylarginine in peripheral arterial disease: a randomized controlled trial. | 21481871 |
| Childhood Breast Carcinoma, Metaplastic carcinoma | Stem Cell Exhaustion | Responses to liposomal Doxorubicin, bevacizumab, and temsirolimus in metaplastic carcinoma of the breast: biologic rationale and implications for stem-cell research in breast cancer. | 21482991 |
| Werner Syndrome, Progeria | Stem Cell Exhaustion | Here we describe the generation of induced pluripotent stem cells (iPSCs) from a patient with inherited dilated cardiomiopathy and 2 patients with distinct accelerated forms of aging, atypical Werner syndrome and Hutchinson Gilford progeria, all of which are caused by mutations in lamin A/C. | 21483033 |
| Granuloma of conjunctiva, Conjunctival melanosis, Special Handling Code - Dry | Stem Cell Exhaustion | Associated ocular features were limbal stem cell deficiency in nine eyes (64.3%), dry eye in all 14 eyes (100%), conjunctival melanosis in seven eyes (50%), pseudopterygium in two eyes (14.3%), anterior symblepharon in three eyes (21.4%) and conjunctival inflammatory granuloma in one eye (7.1%). | 21484462 |
| Angina Pectoris, Coronary Arteriosclerosis | Stem Cell Exhaustion | We evaluated the feasibility, safety and efficacy of intra-myocardial injection of autologous mesenchymal stromal cells derived endothelial progenitor cell (MSC) in patients with stable coronary artery disease (CAD) and refractory angina in this first in man trial. | 21486102 |
| Cardiovascular Diseases | Stem Cell Exhaustion | Statins, a major component of the prevention of cardiovascular disease, aid progenitor cell functions in vivo and in vitro. | 21486281 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Impact of the use of autologous stem cell transplantation at first relapse both in naive and previously rituximab exposed follicular lymphoma patients treated in the GELA/GOELAMS FL2000 study. | 21486862 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Regardless of front-line rituximab exposure, this study supports incorporating autologous stem cell transplantation in the therapeutic approach at first relapse for follicular lymphoma patients. | 21486862 |
| Enterovirus Gastroenteritis | Stem Cell Exhaustion | Norovirus gastroenteritis causes severe and lethal complications after chemotherapy and hematopoietic stem cell transplantation. | 21487110 |
| Cerebral Hemorrhage | Stem Cell Exhaustion | Cd34+ progenitor cells likely are involved in the good functional recovery after intracerebral hemorrhage in humans. | 21488087 |
| COL4A2 wt Allele, Cerebral Hemorrhage | Stem Cell Exhaustion | Our aim was to study the influence of CD34(+) progenitor cells in the outcome of intracerebral hemorrhage (ICH). | 21488087 |
| COL4A2 wt Allele | Stem Cell Exhaustion | These findings suggest that CD34(+) progenitor cells may participate in the functional recovery of ICH patients. | 21488087 |
| Hodgkin Disease, Malignant Fibrous Histiocytoma | Stem Cell Exhaustion | Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: evidence for genomic instability. | 21488163 |
| Autistic Disorder, Malignant Fibrous Histiocytoma | Stem Cell Exhaustion | We report a 14 year old autistic male, who developed malignant fibrous histiocytoma (MFH) two years after autologous stem cell transplantation for advanced stage HL. | 21488163 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Plerixafor is a recently Food and Drug Administration (FDA)-approved CXCR4 antagonist, which is combined with granulocyte-colony-stimulating factor (G-CSF) to facilitate stem cell mobilization of lymphoma and myeloma patients. | 21492180 |
| Hematologic Neoplasms | Stem Cell Exhaustion | The targeted use of plerixafor increased the overall success rate of mobilizing a minimum number of CD34+ cells from 93% to 98% in patients with hematologic malignancies scheduled for autotransplant and increased the overall charges associated with stem cell collection in all patients by an average of 17%. | 21492180 |
| Cell Growth, Malignant Neoplasms, Venous Thromboembolism, Neoplasms, Communicable Diseases, Progressive neurologic deterioration | Stem Cell Exhaustion | We did not observe any central nervous system tumours, abnormal cell growths or neurological deterioration, and there was no evidence for venous thromboembolism, systemic malignancy or systemic infection in any of the patients following stem cell infusion. | 21493695 |
| Cerebrovascular accident | Stem Cell Exhaustion | While we would emphasize that the current study was unblinded, did not assess overall function or relative functional importance of different types of deficits, and does not exclude placebo effects or a contribution of recovery as a result of the natural history of stroke, our observations provide evidence supporting the feasibility and safety of delivery of a relatively large dose of autologous mesenchymal human stem cells, cultured in autologous human serum, into human subjects with stroke and support the need for additional blinded, placebo-controlled studies on autologous mesenchymal human stem cell infusion in stroke. | 21493695 |
| Cerebrovascular accident | Stem Cell Exhaustion | Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke. | 21493695 |
| Cerebrovascular accident, Infarction | Stem Cell Exhaustion | Transplantation of human mesenchymal stem cells has been shown to reduce infarct size and improve functional outcome in animal models of stroke. | 21493695 |
| Cerebrovascular accident | Stem Cell Exhaustion | Here, we report a study designed to assess feasibility and safety of transplantation of autologous human mesenchymal stem cells expanded in autologous human serum in stroke patients. | 21493695 |
| Cerebral cortex | Stem Cell Exhaustion | We report an unblinded study on 12 patients with ischaemic grey matter, white matter and mixed lesions, in contrast to a prior study on autologous mesenchymal stem cells expanded in foetal calf serum that focused on grey matter lesions. | 21493695 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | A comparison of oral mucositis in allogeneic hematopoietic stem cell transplantation between conventional and reduced-intensity regimens. | 21494780 |
| Bacteremia, Gastrointestinal mucositis, Usual Severity Pain | Stem Cell Exhaustion | Severe oral mucositis developed in allogeneic hematopoietic stem cell transplantation (HSCT) accompanies intolerable pain and risk for systemic bacteremia infection. | 21494780 |
| Stomatitis | Stem Cell Exhaustion | Conventional stem cell transplantation (CST) and reduced-intensity regimens for allogeneic HSCT (RIST) may differently affect the occurrence and severity of oral mucositis. | 21494780 |
| Prostate carcinoma | Stem Cell Exhaustion | Haplotype analysis of prostate stem cell antigen and association with prostate cancer risk. | 21497359 |
| Prostate carcinoma | Stem Cell Exhaustion | Prostate stem cell antigen has become a promising target as a potential biomarker for prostate cancer, but to our knowledge there are no reports of a genetic variation of the PSCA gene associated with prostate cancer risk. | 21497359 |
| Fibroid Tumor | Stem Cell Exhaustion | To address the influence of genes involved in stem cell self-renewal and senescence on the growth of leiomyoma cells in vitro and to explore possible therapeutic implications of a targeted disruption of the p53-murine double minute 2 (MDM2) interaction. | 21498692 |
| Acute leukemia, Aplastic Anemia, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) was performed in 37 cases of acute leukemia, 10 of myelodysplastic syndrome, 5 of aplastic anemia, and 5 others. | 21502710 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplantation (auto-HSCT) was performed in 34 cases of malignant lymphoma, 15 of multiple myeloma, and 8 others. | 21502710 |
| Nephrotic Syndrome, Amyloid nephropathy | Stem Cell Exhaustion | A long-term remission of renal amyloidosis with nephrotic syndrome after autologous peripheral blood stem-cell transplantation. | 21502717 |
| Nephrotic Syndrome, Amyloid nephropathy | Stem Cell Exhaustion | We report the case of a patient with renal amyloidosis associated with nephrotic syndrome who maintained remission for 6 years after undergoing high-dose chemotherapy followed by autologous peripheral blood stem-cell transplantation (auto-PBSCT). | 21502717 |
| Glioma | Stem Cell Exhaustion | Neuroepithelial stem cell marker nestin regulates the migration, invasion and growth of human gliomas. | 21503585 |
| liver and pancreas | Stem Cell Exhaustion | CX32 has three tissue-specific promoters, P1 which is specific for liver and pancreas, P1a specific for liver, oocytes and embryonic stem cells, and P2 which is nerve-specific. | 21504505 |
| Hematological Disease, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | In this study, we used Myelodysplastic Syndromes (MDSs), a heterogeneous family of clonal disorders of hematopoietic stem cells, as a general model to explore the network properties of the heterogeneity of complex diseases. | 21505650 |
| Specialty Type - cancer | Stem Cell Exhaustion | Taken together, our results show that cancer cells can program proangiogenic activity in CD11b(+) myelomonocytes during differentiation of their progenitor cells in a PlGF-dependent manner. | 21507936 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Patterns and outcome of relapse after autologous stem cell transplantation for mantle cell lymphoma. | 21509767 |
| Medial collateral ligament, Mantle cell lymphoma | Stem Cell Exhaustion | Autologous stem cell transplantation (autoSCT) has improved the outcome of patients with mantle cell lymphoma (MCL) considerably. | 21509767 |
| Therapy-related myelodysplastic syndrome | Stem Cell Exhaustion | In this study, we carried out metabolomic analysis of peripheral blood stem cell samples collected in a cohort of patients before hematopoietic cell transplantation to gain insights into the molecular and cellular pathogenesis of t-MDS. | 21510650 |
| Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Tumors with constitutive LIN28B expression exhibit increased expression of colonic stem cell markers LGR5 and PROM1, mucinous differentiation, and metastasis. | 21512136 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Successful neutrophil engraftment by reduced use of granulocyte colony-stimulating factor after allogeneic hematopoietic stem cell transplantation with mycophenolate mofetil for graft-versus-host disease prophylaxis. | 21512728 |
| HD Term Type | Stem Cell Exhaustion | In allogeneic hematopoietic stem cell transplantation (allo-SCT), most physicians in Japan utilize granulocyte colony-stimulating factor (G-CSF) at a high dose (HD) of 300 mg/m(2) per day for filgrastim to promote faster neutrophil engraftment. | 21512728 |
| Malignant Neoplasms | Stem Cell Exhaustion | Underlying conditions were haematopoietic stem cell transplantation (HSCT, 35), haematologic malignancy (HM, 35), solid-organ transplantation (SOT, 25), chronic immunosuppression (CI, 40) and other conditions (OC, 57). | 21512792 |
| Communicable Diseases | Stem Cell Exhaustion | In immunocompetent persons, cytomegalovirus (CMV) is thought to persist primarily in monocytes and myeloid progenitor cells, establishing a chronic infection. | 21513787 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Patients with hematologic malignancies and hematopoietic stem cell transplantation recipients admitted to the hospital. | 21515980 |
| Angina, Unstable, Infarction | Stem Cell Exhaustion | Influence of preinfarction angina on the release kinetics of endothelial progenitor cells and cytokines during the week after infarction. | 21517829 |
| Angina, Unstable | Stem Cell Exhaustion | The aim of this study was to determine the possible involvement of endothelial progenitor cells (EPC), the vascular endothelial growth factor (VEGF) and the hepatocyte growth factor (HGF) in the development of preinfarction angina. | 21517829 |
| Acute leukemia | Stem Cell Exhaustion | We performed a retrospective single-center analysis of 604 CVC insertions in 193 patients with acute leukemia receiving intensive chemotherapy or stem cell transplantation. | 21517892 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Mesenchymal stem cell therapy for knee osteoarthritis. | 21518322 |
| Hematologic Neoplasms | Stem Cell Exhaustion | [Comparison of curative efficacy after G-CSF-mobilized sibling HLA-matched peripheral blood hematopoietic stem cell transplantation versus that combined with BMT for patients with hematologic malignancies in a single center]. | 21518497 |
| Hematologic Neoplasms | Stem Cell Exhaustion | This study was aimed to retrospectively analyze and compare the clinical curative efficacy of patients with hematologic malignancies after G-CSF-mobilized sibling HLA-matched (sm) peripheral blood hematopoietic stem cell transplantation (sm-allo-PBHSCT) and sm-allo-PBHSCT combined with bone marrow transplantation (BMT). | 21518497 |
| Alzheimers Disease | Stem Cell Exhaustion | Endothelial progenitor cells with Alzheimer's disease. | 21518600 |
| Up | Stem Cell Exhaustion | The patients with AD had significantly lower CD34(+)CD133(+) EPCs (CD34 and CD133 double positive endothelial progenitor cells) than the control subjects (P < 0.05). | 21518600 |
| Abnormality of red blood cells | Stem Cell Exhaustion | Most patients (16/22) with high myeloid progenitor cells (MyPC) (> 20%) also exhibited maturing myeloid cell abnormalities by FCM. | 21520402 |
| Neoplasms, Childhood Breast Carcinoma | Stem Cell Exhaustion | An imbalance in progenitor cell populations reflects tumour progression in breast cancer primary culture models. | 21521500 |
| Childhood Breast Carcinoma, Neoplasms | Stem Cell Exhaustion | Many factors influence breast cancer progression, including the ability of progenitor cells to sustain or increase net tumour cell numbers. | 21521500 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Deletions of derivative chromosome 9 are a poor prognostic factor in patients with chronic myeloid leukemia (CML) treated with hydroxyurea, interferon, or stem cell transplantation. | 21523765 |
| leukemia | Stem Cell Exhaustion | We are the first to demonstrate a direct link between stem cell factor SALL4, SP and drug resistance in leukemia. | 21526180 |
| Specialty Type - cancer | Stem Cell Exhaustion | This led to our investigation of the implication of SALL4 in drug resistance and its role in side population (SP) cancer stem cells. | 21526180 |
| PAFAH1B1 wt Allele, Aplastic Anemia, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | In aplastic anemia (AA), contraction of the stem cell pool may result in oligoclonality, while in myelodysplastic syndromes (MDS) a single hematopoietic clone often characterized by chromosomal aberrations expands and outcompetes normal stem cells. | 21527527 |
| Choroidal Neovascularization | Stem Cell Exhaustion | Amyloid beta enhances migration of endothelial progenitor cells by upregulating CX3CR1 in response to fractalkine, which may be associated with development of choroidal neovascularization. | 21527754 |
| Choroidal Neovascularization | Stem Cell Exhaustion | We have also shown that endothelial progenitor cells (EPCs) may contribute to the development of choroidal neovascularization (CNV). | 21527754 |
| Intrahepatic bile duct, Liver Cirrhosis, Hollings Cancer Center, Cholangiocarcinoma | Stem Cell Exhaustion | It seems possible in this case that hepatic progenitor cells located in reactive bile ductules in liver cirrhosis may have been responsible for the development of the cholangiocarcinoma and HCC, and that the former could have spread in the intrahepatic bile ducts and eventually formed grossly visible IPNB. | 21528069 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | The myelodysplastic syndromes (MDSs) are hematologically diverse hematopoietic stem cell malignancies primarily affecting older individuals. | 21531980 |
| Behavior, Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | The new cancer stem cell concept proposes that the expression of such genes is potentially correlated with tumorigenesis and can affect some aspects of the cancer behavior, such as recurrence or metastasis. | 21533858 |
| Multiple Myeloma | Stem Cell Exhaustion | Melphalan 100 mg/m2 with stem cell support as first relapse treatment is safe and effective for myeloma patients with long remission after autologous stem cell transplantation. | 21535157 |
| Multiple Myeloma | Stem Cell Exhaustion | Today, a number of therapeutic options are available as the patient with myeloma relapses from initial treatment with high-dose melphalan and autologous stem cell transplantation (ASCT). | 21535157 |
| Multiple Myeloma | Stem Cell Exhaustion | In this retrospective study, we account for the outcome of 66 patients with myeloma in first systemic relapse after ASCT, who were treated with intermediate-dose melphalan, 100 mg/m2, and stem cell support (MEL 100). | 21535157 |
| Alzheimers Disease | Stem Cell Exhaustion | Tenuigenin, an active component of Polygala tenuifolia root extracts, has been shown to provide antioxidative and anti-aging effects in Alzheimer's disease, as well as to promote proliferation and differentiation of neural progenitor cells. | 21536104 |
| Supraventricular Tachycardia by ECG Finding, Supraventricular tachycardia | Stem Cell Exhaustion | We retrospectively reviewed the data on patients who received hematopoietic stem cell transplant (bone marrow transplant; BMT) from 1998 to 2005 and developed supraventricular tachycardia (SVT) during the same hospital admission. | 21538392 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | Association of a common genetic variant in prostate stem-cell antigen with gastric cancer susceptibility in a Korean population. | 21538581 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | A recent genome wide association study (GWAS) indentified a significant association between rs2294008 (C > T) polymorphism in prostate stem-cell antigen (PSCA) and increased risk of gastric cancer in Japanese and Korean populations. | 21538581 |
| Graft-vs-Host Disease, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Donor lymphocyte infusions have been effective in patients with chronic myeloid leukemia (CML) relapsing after allogeneic stem cell transplantation, but their use is associated with the risk of graft-versus-host disease. | 21540460 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Fourteen CML patients received conditioning therapy followed by CD34(+)-selected peripheral blood stem cells from matched siblings (n = 7) or unrelated (n = 7) donors. | 21540460 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The impact of early human cytomegalovirus (HCMV) replication on leukemic recurrence was evaluated in 266 consecutive adult (median age, 47 years; range, 18-73 years) acute myeloid leukemia patients, who underwent allogeneic stem cell transplantation (alloSCT) from 10 of 10 high-resolution human leukocyte Ag-identical unrelated (n = 148) or sibling (n = 118) donors. | 21540462 |
| Aplastic Anemia | Stem Cell Exhaustion | First-line matched related donor hematopoietic stem cell transplantation compared to immunosuppressive therapy in acquired severe aplastic anemia. | 21541024 |
| Aplastic Anemia | Stem Cell Exhaustion | Acquired severe aplastic anemia (SAA) is a rare and progressive disease characterized by an immune-mediated functional impairment of hematopoietic stem cells. | 21541024 |
| Coronary artery, Restenosis | Stem Cell Exhaustion | Two-year follow-up of the Genous(tm) endothelial progenitor cell capturing stent versus the Taxus Liberte stent in patients with de novo coronary artery lesions with a high-risk of restenosis: a randomized, single-center, pilot study. | 21542109 |
| Atherosclerosis | Stem Cell Exhaustion | Endothelial progenitor cells (CD34+KDR+) and monocytes may provide the development of good coronary collaterals despite the vascular risk factors and extensive atherosclerosis. | 21543296 |
| Atherosclerosis, Coronary Arteriosclerosis | Stem Cell Exhaustion | Endothelial progenitor cells can be mobilized from bone marrow to induce the coronary collateral growth in case of myocardial ischemia even in presence of the vascular risk factors and extensive atherosclerosis. | 21543296 |
| Idiopathic Pulmonary Fibrosis | Stem Cell Exhaustion | Mutations in the genes encoding telomerase (TERT and TERC) cause IPF through shortening of telomere lengths and probable exhaustion of lung stem cells. | 21543794 |
| Hepatitis B | Stem Cell Exhaustion | Development of immunity against hepatitis B virus after donor lymphocyte infusion in a peripheral blood stem cell transplantation recipient with chronic hepatitis B. | 21544586 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | She received allogeneic matched unrelated donor peripheral blood stem cell transplantation (allo-MUD-PBSCT) for her refractory acute myeloid leukemia (AML). | 21544586 |
| Specialty Type - cancer | Stem Cell Exhaustion | Development and implementation of an Internet-based survivorship care program for cancer survivors treated with hematopoietic stem cell transplantation. | 21544671 |
| Osteoporotic Fractures | Stem Cell Exhaustion | Proliferation and differentiation potential of human adipose-derived mesenchymal stem cells isolated from elderly patients with osteoporotic fractures. | 21545685 |
| Osteoporotic Fractures | Stem Cell Exhaustion | Aging has less effect on adipose-derived mesenchymal stem cells (ADSCs) than on bone marrow-derived mesenchymal stem cells (BMSCs), but whether the fact holds true in stem cells from elderly patients with osteoporotic fractures is unknown. | 21545685 |
| Hematopoietic Cell Transplant Recipient | Stem Cell Exhaustion | A prospective study was performed to collect data regarding risk factors and outcome of A/H1N1 in hematopoietic stem cell transplant recipients. | 21546495 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Targeting constitutively activated FMS-like tyrosine kinase 3 [(FLT3); FLT3-ITD] with tyrosine kinase inhibitor (TKI) in acute myeloid leukemia (AML) leads to clearance of blasts in the periphery but not in the bone marrow, suggesting a protective effect of the marrow niche on leukemic stem cells. | 21546568 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Thus, TKIs with first-generation inhibitors fail to eradicate early leukemic stem/progenitor cells in FLT3-ITD(+) AML. | 21546568 |
| Heart failure | Stem Cell Exhaustion | hCSCs expressing only IGF-1R synthesize both IGF-1 and IGF-2, which are potent modulators of stem cell replication, commitment to the myocyte lineage, and myocyte differentiation, which points to this hCSC subset as the ideal candidate cell for the management of human heart failure. | 21546606 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | Age and coronary artery disease may negatively affect the function of human cardiac stem cells (hCSCs) and their potential therapeutic efficacy for autologous cell transplantation in the failing heart. | 21546606 |
| Neoplasms, Malignant neoplasm of ovary, Specialty Type - cancer | Stem Cell Exhaustion | Recently, accumulating evidence has suggested that tumors, including ovarian cancer, are composed of a heterogeneous cell population with a small subset of cancer stem cells (CSCs) that sustain tumor formation and growth. | 21547690 |
| Hepatitis B, Multiple Myeloma, Communicable Diseases | Stem Cell Exhaustion | Risk of hepatitis B reactivation and the role of novel agents and stem-cell transplantation in multiple myeloma patients with hepatitis B virus (HBV) infection. | 21551005 |
| Osteopetrosis | Stem Cell Exhaustion | She later went on to have stem cell transplantation to treat the osteopetrosis. | 21552996 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | Stem cell associated genes working with one miRNA cluster have different clinic pathologic values in gastric cancer. | 21553350 |
| Malignant Neoplasms | Stem Cell Exhaustion | Also, stem cell associated genes are emerging as predictors of cancer malignancy. | 21553350 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells are nowadays considered to be the origin of cancer. | 21553350 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | She was treated with combined acute myeloid leukaemia/acute lymphoblastic leukaemia induction therapy followed by autologous stem cell transplantation. | 21553470 |
| Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0 | Stem Cell Exhaustion | To investigate the presence of T cells with natural killer cell receptors (NKR) in paroxysmal nocturnal hemoglobinuria (PNH), and their potential involvement in clonal expansion of glycosylphosphatidylinositol (GPI)-deficient hematopoietic stem cells by selective immune attack to normal and not GPI-deficient hematopoietic stem cells. | 21554925 |
| Hemoglobinuria, CTCAE 3.0 | Stem Cell Exhaustion | T cells expressing the activating NK-cell receptors KIR2DS4, NKG2C and NKG2D are elevated in paroxysmal nocturnal hemoglobinuria and cytotoxic toward hematopoietic progenitor cell lines. | 21554925 |
| Paroxysmal nocturnal hemoglobinuria | Stem Cell Exhaustion | Elevated T cell subsets in PNH were assessed for differential cytotoxic lysis of GPI(+) and GPI(-) CD34(+) hematopoietic progenitor cell lines. | 21554925 |
| Paroxysmal nocturnal hemoglobinuria | Stem Cell Exhaustion | NKR(+) cytotoxic T-lymphocyte lines isolated from PNH patient peripheral blood and bone marrow displayed high cytotoxicity towards CD34(+) hematopoietic progenitor cell lines and K562 cells, suggesting major histocompatibility complex class I-independent cytotoxicity. | 21554925 |
| Leukemia, Myelocytic, Acute, Chromosome Aberrations | Stem Cell Exhaustion | Persistence of cytogenetic abnormalities at complete remission after induction in patients with acute myeloid leukemia: prognostic significance and the potential role of allogeneic stem-cell transplantation. | 21555694 |
| Leukemia, Myelocytic, Acute, Chromosome Aberrations | Stem Cell Exhaustion | To determine the prognostic impact of persistent cytogenetic abnormalities at complete remission (CR) on relapse-free survival (RFS) and overall survival (OS) in patients with acute myeloid leukemia (AML) and to examine the potential role of allogeneic stem-cell transplantation (SCT) in this setting. | 21555694 |
| Prostate carcinoma | Stem Cell Exhaustion | Endothelial progenitor cells and circulating endothelial cells in early prostate cancer: a comparison with plasma vascular markers. | 21557269 |
| Specialty Type - cancer | Stem Cell Exhaustion | Separate studies indicate that endothelial perturbation, as demonstrated by abnormal endothelial progenitor cells (EPCs), circulating endothelial cells (CECs), and plasma markers such as von Willebrand factor (vWf) and soluble E selectin (sEsel) are present in cancer. | 21557269 |
| Thalassemia | Stem Cell Exhaustion | Antiphospholid antibody syndrome and Hb E/Beta thalassemia disease post-allogeneic stem cell transplantation. | 21557460 |
| Stable chronic Graft vs Host Disease, Thalassemia, Chronic graft-versus-host disease, Antiphospholipid Antibodies | Stem Cell Exhaustion | We report a 10-year-old male with Hb E/Beta thalassemia disease who developed chronic graft-versus-host disease (cGVHD) of antiphospholipid antibody syndrome after successful allogeneic stem cell transplantation (SCT). | 21557460 |
| Branchioma, S100A4 protein, human | Stem Cell Exhaustion | Branchial cyst carcinoma revisited: stem cells, dormancy and malignant transformation. | 21558916 |
| Carcinogenesis | Stem Cell Exhaustion | The wide recognition of stem cells and their role in carcinogenesis provides a new context for the etiopathogenesis of controversial and rare entities such as the BCCC. | 21558916 |
| Branchioma, Neoplasms | Stem Cell Exhaustion | We argue for the first time the hypothesis that congenital branchial cysts and BCCC tumors may result from progenitor cell rests of the embryological branchial development. | 21558916 |
| Histogenic Process | Stem Cell Exhaustion | Although the histogenesis of ESFT is controversial, mesenchymal (MSC) and/or neural crest (NCSC) stem cells have been implicated as cells of origin. | 21559395 |
| Kidney Diseases, Stricture of ureter, Hemorrhagic cystitis | Stem Cell Exhaustion | Polyoma virus is a recognized cause of hemorrhagic cystitis, viral nephropathy, and ureteral stricture in renal and stem cell transplant recipients. | 21559788 |
| Lymphoproliferative Disorders | Stem Cell Exhaustion | Epstein-Barr virus-associated post-transplant lymphoproliferative disease (EBV-PTLD) is a life-threatening complication following allogeneic hematopoietic stem cell transplantation (HSCT). | 21559814 |
| Immunologic Deficiency Syndromes, Communicable Diseases | Stem Cell Exhaustion | We report an 11-month-old boy with severe combined immunodeficiency dying of serious disseminated BCG infection despite anti-tuberculosis therapy and blood stem cell transplantation. | 21560422 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Autologous blood stem cell transplantation for Hodgkin and non-Hodgkin lymphoma: complications and outcome. | 21561042 |
| Toxic effect, Infection, Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | We analysed data on patients of Hodgkin and non-Hodgkin lymphoma treated with high dose chemotherapy followed by autologous stem cell transplantation to determine the toxicity, pattern of infections and long-term outcome. | 21561042 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | Our findings suggest that alterations in KIR/KIR-L matching, such as increased 3DL2 and decreased 2DS1 mismatch, and in the polymorphisms of TGFb1, IFN-g, TNF- a and IL-10 may account for the propensity to immunemediated killing of hematopoietic stem cells and/or ineffective hematopoiesis characteristic of AA and MDS. | 21561401 |
| Disease, Hyperplasia | Stem Cell Exhaustion | Mastocytoses represent a heterogeneous group of stem cell disorders marked by an abnormal hyperplasia and accumulation of mast cells in one or more tissues, including bone marrow, gastrointestinal tract, liver, spleen, lymph nodes and skin. | 21564325 |
| Hepatitis B | Stem Cell Exhaustion | Changes of hepatitis B virus serologic status after allogeneic hematopoietic stem cell transplantation and impact of donor immunity on hepatitis B virus. | 21565276 |
| Multiple Myeloma | Stem Cell Exhaustion | Factors influencing the outcome of a second autologous stem cell transplant (ASCT) in relapsed multiple myeloma: a study from the British Society of Blood and Marrow Transplantation Registry. | 21565277 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Autologous stem cell transplant as primary (first ASCT) therapy in multiple myeloma (MM) is standard practice. | 21565277 |
| Hematologic Neoplasms, Pregnancy Complications, Infectious, Mycoses | Stem Cell Exhaustion | An electronic medical record system, the "Hema e-Chart", was designed and implemented to collect information prospectively on infectious complications, particularly on invasive fungal diseases, in patients with hematologic malignancies treated with chemotherapy and/or autologous or allogenic hemopoietic stem cell transplantation. | 21565903 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | This study shows an extremely low incidence of meningeal relapse in adult patients with acute myeloid leukemia treated with modern protocols including stem cell transplantation without intrathecal prophylaxis. | 21565904 |
| Thrombasthenia | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation in Glanzmann thrombasthenia complicated by platelet alloimmunization. | 21567370 |
| Thrombasthenia | Stem Cell Exhaustion | For Thrombasthenia Glanzmann (GT) patients presenting with a severe clinical phenotype due to complete lack of thrombocyte function or increased titres of anti-platelet antibodies hematopoietic stem cell transplantation (SCT) is the only curative therapy. | 21567370 |
| Antilymphocyte Serum | Stem Cell Exhaustion | The intrathecal synthesis of CCL2 suggests the involvement of adult neural stem cells and microglial activation in ALS pathogenesis which needs further investigation. | 21569455 |
| Ocular Cicatricial Pemphigoid, Corneal dystrophy, Lattice type 3, Burn injury, Stevens-Johnson Syndrome | Stem Cell Exhaustion | Forty eyes in 36 patients with total limbal stem cell deficiency (Stevens-Johnson syndrome in 12 eyes, chemical or thermal burns in 11 eyes, ocular cicatricial pemphigoid [OCP] in 9 eyes, pseudo-OCP in 7 eyes, and gelatinous drop-like dystrophy in 1 eye) were treated at the Department of Ophthalmology, Tokyo Dental College, Chiba, Japan. | 21571372 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Assessing the charges associated with hematopoietic stem cell mobilization and remobilization in patients with lymphoma and multiple myeloma undergoing autologous hematopoietic peripheral blood stem cell transplantation. | 21575005 |
| Hematopoietic Stem Cell Mobilization | Stem Cell Exhaustion | The purpose of this study was to perform a detailed analysis of the charges associated with chemomobilization and remobilization of autologous hematopoietic stem cells (HSCs) and to quantify medical costs and resource utilization associated with these procedures. | 21575005 |
| Aneurysm, Ruptured | Stem Cell Exhaustion | Mobilization of circulating endothelial progenitor cells after endovascular therapy for ruptured cerebral aneurysms. | 21575677 |
| Vascular System Injuries | Stem Cell Exhaustion | Emerging evidence shows that circulating endothelial progenitor cells (EPCs) promote regeneration of the endothelium at sites of vessel injury. | 21575677 |
| BCL6 Positive | Stem Cell Exhaustion | (90)Y ibritumomab tiuxetan (Zevalin) combined with BEAM (Z -BEAM) conditioning regimen plus autologous stem cell transplantation in relapsed or refractory low-grade CD20-positive B-cell lymphoma. | 21575926 |
| Lymphoma | Stem Cell Exhaustion | This study was designed to evaluate the safety and efficacy of a conventional dose of yttrium-90 ((90)Y) ibritumomab tiuxetan combined with the etoposide rabinoside acytarabine melphalan (BEAM) regimen before autologous stem cell transplantation (ASCT) in chemosensitive relapsed or refractory low-grade B-cell lymphomas. | 21575926 |
| palladium, Parkinson Disease | Stem Cell Exhaustion | Parkinson disease (PD) involves the selective loss of midbrain dopamine (mDA) neurons and is a possible target disease for stem cell-based therapy. | 21576821 |
| Trigeminal Neuralgia, Diplopia | Stem Cell Exhaustion | Extramedullary relapse presenting as trigeminal neuralgia and diplopia after allogeneic hematopoietic stem cell transplantation. | 21576839 |
| Trigeminal Neuralgia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | A 23-year-old woman presented with trigeminal neuralgia four months after hematopoietic stem cell transplantation (HSCT) for acute myeloblastic leukemia. | 21576839 |
| Colorectal Carcinoma | Stem Cell Exhaustion | Expression of the adult intestinal stem cell marker Lgr5 in the metastatic cascade of colorectal cancer. | 21577318 |
| Specialty Type - cancer, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | The recently advanced cancer stem cell model postulates that progression and metastasis of cancer are mainly driven by tumor cells with stem cell properties. | 21577318 |
| Colorectal Carcinoma, Intestinal Cancer | Stem Cell Exhaustion | Intestinal cancer stem cells are difficult to study due to the lack of reliable markers, but expression of the Wnt target gene Lgr5 is promising to define at least stem cell like cells in intestinal and colorectal cancer. | 21577318 |
| Colorectal Carcinoma | Stem Cell Exhaustion | The aim of this study was to find a possible link of stem cell like cancer cells to the metastatic process of colorectal cancer. | 21577318 |
| Colorectal Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | In conclusion, our results point to rare evidence of Lgr5 positive stem cell like cells in the metastatic cascade of colorectal cancer, but these few cells might be biologically powerful in the metastatic process of cancer subsets. | 21577318 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Intermediate intensity conditioning regimen containing FLAMSA, treosulfan, cyclophosphamide, and ATG for allogeneic stem cell transplantation in elderly patients with relapsed or high-risk acute myeloid leukemia. | 21584670 |
| Toxic effect | Stem Cell Exhaustion | Lower dosage of total body irradiation (TBI) and chemotherapy in reduced-intensity conditioning (RIC) regimens prior to allogeneic stem cell transplantation have reduced the toxicity of the conditioning and non-relapse mortality. | 21584670 |
| Impaired cognition, "Alzheimers Disease | Stem Cell Exhaustion | Stem cell factor plasma levels are decreased in Alzheimer's disease patients with fast cognitive decline after one-year follow-up period: the Pythia-study. | 21593573 |
| Stem Cell Factor | Stem Cell Exhaustion | Stem cell factor (SCF) is a hematopoietic growth factor that promotes neuroprotective effects and supports neurogenesis in the brain. | 21593573 |
| REG1CP gene, Neoplastic Stem Cells | Stem Cell Exhaustion | We conclude that the presence of >=15% RS in the post-therapy setting is not necessarily indicative of a clonal stem cell neoplasm. | 21596435 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Several studies have been directed toward using MSCs from patients with osteoarthritis (OA) for cartilage repair, not only because these are the ones that will require a source of autologous stem cells if biological repair of cartilage lesions is to be a therapeutic option, but also to further an understanding of stem cell differentiation. | 21599539 |
| Neutropenia, Infection, Multiple Myeloma | Stem Cell Exhaustion | CD4(+) CD28(+) lymphocytes on day 5 after high-dose melphalan for multiple myeloma predict a low risk of infections during severe neutropenia and are associated with the number of reinfused T lymphocytes of the autologous stem cell graft. | 21599548 |
| Multiple Myeloma | Stem Cell Exhaustion | Residual leukocytes in the peripheral blood on day 5 after autologous blood stem cell transplantation were analyzed by three-color flow cytometry in 55 consecutive patients with multiple myeloma. | 21599548 |
| Multiple Myeloma | Stem Cell Exhaustion | Prognostic value of bone marrow microvessel density and angiogenic cytokines in patients with multiple myeloma undergoing autologous stem cell transplant. | 21599578 |
| Septicemia | Stem Cell Exhaustion | Blood stream infections after allogeneic stem cell transplantation: a single-center experience with the use of levofloxacin prophylaxis. | 21599817 |
| Septicemia, Behavioral Symptoms Index Composite Score (BASC-2) | Stem Cell Exhaustion | Blood stream infections (BSIs) remain one of the major causes of morbidity and mortality for patients receiving an allogeneic hematopoietic stem cell transplantation (HSCT). | 21599817 |
| Prostate carcinoma | Stem Cell Exhaustion | Expression of prostate-specific antigen (PSA), prostate-specific membrane antigen (PSMA), human kallikrein 2 (hK2), prostate stem cell antigen (PSCA), and differential display code 3 (DD3) in 2215 LNs isolated from 120 patients with localized prostate cancer were assessed by fully quantitative real-time RT-PCR. | 21600799 |
| Premalignant, Specialty Type - cancer | Stem Cell Exhaustion | Repositioning chloroquine and metformin to eliminate cancer stem cell traits in pre-malignant lesions. | 21600837 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Such ideal molecules, which are expected to molecularly abrogate all the instrumental mechanisms acquired by migrating cancer stem cells (CSCs) to by-pass tumour suppressor barriers, might already exist. | 21600837 |
| Hodgkin Disease | Stem Cell Exhaustion | Prognostic significance of FDG-PET in relapsed or refractory classical Hodgkin lymphoma treated with standard salvage chemotherapy and autologous stem cell transplantation. | 21601641 |
| Malignant Neoplasms | Stem Cell Exhaustion | Fludarabine, antithymocyte globulin, and very low-dose busulfan for reduced-intensity conditioning before allogeneic stem cell transplantation in patients with lymphoid malignancies. | 21601642 |
| Specialty Type - cancer, Squamous cell carcinoma | Stem Cell Exhaustion | To detect the expression of stem cell transcription factor Oct-4 in squamous cell carcinoma (SCC) and seborrheic keratosis (SK) and its association with cancer stem cells. | 21602158 |
| Neoplasms | Stem Cell Exhaustion | The Oct-4-positive cells in SCC and SK are probably tumor stem cells. | 21602158 |
| Liver Failure, Hepatitis B | Stem Cell Exhaustion | Autologous bone marrow mesenchymal stem cell transplantation in liver failure patients caused by hepatitis B: short-term and long-term outcomes. | 21608000 |
| Liver Failure, Hepatitis B | Stem Cell Exhaustion | Our study aimed to investigate the short-term efficacy and long-term prognosis of liver failure patients caused by hepatitis B after a single transplantation with autologous marrow mesenchymal stem cells (MMSCs). | 21608000 |
| Specialty Type - cancer | Stem Cell Exhaustion | (v) How the impairment of stem cell fitness, as occurs in old age, can promote selection for adaptive mutations and cancer initiation. | 21610109 |
| Specialty Type - cancer | Stem Cell Exhaustion | (vi) Why differential maintenance of stem cell fitness may explain how different vertebrate species with enormous differences in life span and body size similarly avoid cancer through reproductive years. | 21610109 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Acute graft-versus-host disease (aGvHD) is a common complication of allogeneic stem cell transplantation. | 21616558 |
| Specialty Type - cancer, Pancreatic carcinoma | Stem Cell Exhaustion | Alpha-fetoprotein-producing pancreatic cancer cells possess cancer stem cell characteristics. | 21616586 |
| Specialty Type - cancer, Pancreatic carcinoma | Stem Cell Exhaustion | We aimed to demonstrate the existence of cancer stem cells in human pancreatic cancer, and to clarify that they are alpha-fetoprotein (AFP) producing cells. | 21616586 |
| Pancreatic carcinoma | Stem Cell Exhaustion | The AFP-producing cells were shown to be putative pancreatic cancer stem cells. | 21616586 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | Prospective randomised trial evaluating a paclitaxel-coated balloon in patients treated with endothelial progenitor cell capturing stents for de novo coronary artery disease. | 21617163 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | To define the impact of paclitaxel-coated balloon angioplasty plus endothelial progenitor cell capturing (EPC) stent implantation in de novo coronary artery disease. | 21617163 |
| NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Stem Cell Exhaustion | CD44 as a stem cell marker in head and neck squamous cell carcinoma. | 21617876 |
| Specialty Type - cancer | Stem Cell Exhaustion | These cancer stem cells (CSCs) have features of somatic stem cells such as selfrenewal, proliferation and differentiation. | 21617876 |
| Amyloidosis | Stem Cell Exhaustion | Comparison of hematopoietic progenitor cell collections using the COBE Spectra version 7 and Amicus version 3.1 for patients with AL amyloidosis. | 21618597 |
| Acute Coronary Syndrome | Stem Cell Exhaustion | ACE inhibition modulates endothelial apoptosis and renewal via endothelial progenitor cells in patients with acute coronary syndromes. | 21619382 |
| Neoplasms | Stem Cell Exhaustion | VIL1-positive tumors were further examined histologically and immunostained for epithelial cell surface marker, EpCAM, and mesenchymal stem cell marker, CD44. | 21623163 |
| Psoriasis | Stem Cell Exhaustion | The mesenchymal stem cell profile in psoriasis. | 21623755 |
| Atopy, Psoriasis | Stem Cell Exhaustion | To isolate MSCs in patients with psoriasis and to compare them with those obtained from atopic and healthy subjects, in order to analyse whether MSCs show some typical psoriatic profiles and to understand whether pathophysiological events leading to psoriasis start early at the stem cell level. | 21623755 |
| Sleep disturbances | Stem Cell Exhaustion | Sleep disturbance in hospitalized recipients of stem cell transplantation. | 21624862 |
| Sleep disturbances | Stem Cell Exhaustion | Although sleep disturbances have been studied in recipients of hematopoietic stem cell transplantations (HSCTs), these studies have not examined the acute phase of transplantation. | 21624862 |
| Sleep disturbances, Hemopoietic stem cell transplant | Stem Cell Exhaustion | The current study aimed to identify the level of sleep disturbance in this patient population, identify factors contributing to decreased ability to sleep for hospitalized recipients of HSCT, and compare the differences in sleep disturbance between age, gender, type of transplantation, and initial stem cell transplantation versus readmission for transplantation-associated complications. | 21624862 |
| Multiple System Atrophy | Stem Cell Exhaustion | Mesenchymal stem cells in a transgenic mouse model of multiple system atrophy: immunomodulation and neuroprotection. | 21625635 |
| Psychological Distress | Stem Cell Exhaustion | Family caregivers of allogeneic hematopoietic stem cell transplant (HSCT) patients are at risk for experiencing significant psychological distress yet screening caregivers has not been well studied. | 21626610 |
| Graft-vs-Host Disease, Stable chronic Graft vs Host Disease, Autoimmune Diseases, Chronic graft-versus-host disease | Stem Cell Exhaustion | Because patients with classic and overlap chronic GVHD (cGVHD) have features of autoimmune diseases, we studied the association of recipient and/or donor BAFF SNPs with the phenotype of GVHD after allogeneic stem cell transplantation. | 21628416 |
| Aspergillosis, Acute lymphocytic leukemia | Stem Cell Exhaustion | Isolated cutaneous aspergillosis in an acute lymphoblastic leukemia patient after allogeneic stem cell transplantation. | 21628821 |
| Acute lymphocytic leukemia, Aspergillosis | Stem Cell Exhaustion | We report a 26-year-old male with acute lymphoblastic leukemia who developed cutaneous aspergillosis after undergoing combined immunosuppressive treatment including corticosteroid, cyclosporine A, mychophenolate mofetil and mesenchymal stem cells for steroid refractory skin acute graft versus host disease after myeloablative haematopoietic stem cell transplantation. | 21628821 |
| Anemia, Sickle Cell | Stem Cell Exhaustion | The patient's past medical history was significant for sickle cell disease and she had undergone an allogeneic stem cell transplant 4 months prior with Sirolimus prescribed to prevent rejection. | 21628828 |
| Hepatitis, Lymphohistiocytosis, Hemophagocytic | Stem Cell Exhaustion | We present a case of life-threatening Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) with severe hepatitis that was successfully treated by allogeneic stem cell transplantation from an unrelated donor. | 21628862 |
| Multiple Myeloma | Stem Cell Exhaustion | Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. | 21630163 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | High-dose chemotherapy with subsequent autologous stem cell transplantation (ASCT) is an important treatment option in younger patients with multiple myeloma (MM). | 21630163 |
| Alzheimers Disease | Stem Cell Exhaustion | Adipocytokines and CD34 progenitor cells in Alzheimer's disease. | 21633502 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | Adipocytokines and CD34(+) progenitor cells are associated with the progression and prognosis of atherosclerotic diseases. | 21633502 |
| Up | Stem Cell Exhaustion | In the present study, we measured in 41 patients with early AD and 37 age- and weight-matched healthy controls blood concentrations of adiponectin and leptin by enzyme linked immunoabsorbent assay and of CD34(+) progenitor cells using flow cytometry. | 21633502 |
| Up | Stem Cell Exhaustion | Our findings suggest that low plasma levels of leptin and increased numbers of CD34(+) progenitor cells are both associated with AD. | 21633502 |
| Up | Stem Cell Exhaustion | In addition, the results of our study provide first evidence that increased leptin plasma levels are associated with a reduced number of CD34(+) progenitor cells in AD patients. | 21633502 |
| Up | Stem Cell Exhaustion | These findings point towards a combined involvement of leptin and CD34(+) progenitor cells in the pathogenesis of AD. | 21633502 |
| Up, Coronary Arteriosclerosis | Stem Cell Exhaustion | Thus, plasma levels of leptin and circulating CD34(+) progenitor cells could represent an important molecular link between atherosclerotic diseases and AD. | 21633502 |
| Up | Stem Cell Exhaustion | Further studies should clarify the pathophysiological role of both adipocytokines and progenitor cells in AD and possible diagnostic and therapeutic applications. | 21633502 |
| Respiratory Failure, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Successful allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia during respiratory failure and invasive mechanical ventilation. | 21633813 |
| Hematological Disease | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment option for various hematologic disorders. | 21633813 |
| respiratory | Stem Cell Exhaustion | Because of respiratory deterioration, stem cell infusion was postponed. | 21633813 |
| Astrocytoma | Stem Cell Exhaustion | BRAF activation induces transformation and then senescence in human neural stem cells: a pilocytic astrocytoma model. | 21636552 |
| Neoplasms | Stem Cell Exhaustion | We investigated the functional effect of constitutive BRAF activation in normal human neural stem and progenitor cells to determine its role in tumor induction in the brain. | 21636552 |
| Chronic Kidney Disease, CTCAE | Stem Cell Exhaustion | Effect of darbepoetin alfa on endothelial progenitor cells and vascular reactivity in chronic kidney disease. | 21636677 |
| Liver carcinoma, Specialty Type - cancer, Hollings Cancer Center | Stem Cell Exhaustion | In the present study, we analyzed the regulatory function of RUNX3 on Jagged-1 (JAG1) expression and cancer stem cell (CSC) signaling in hepatocellular carcinoma (HCC). | 21637926 |
| Liver carcinoma, Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Restored expression of the tumor suppressor gene RUNX3 reduces cancer stem cells in hepatocellular carcinoma by suppressing Jagged1-Notch signaling. | 21637926 |
| LMNA wt Allele | Stem Cell Exhaustion | Two groups recently reported the successful generation and characterization of induced pluripotent stem cells (iPSCs) from HGPS fibroblasts. | 21639955 |
| Colorectal Carcinoma | Stem Cell Exhaustion | SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells. | 21640118 |
| Colorectal Carcinoma, Specialty Type - cancer, Cytogenetic Complete Response | Stem Cell Exhaustion | Little is known about the mechanisms that regulate the stem cell-like features of cancer cells; we investigated genes associated with stem cell-like features of colorectal cancer (CRC) cells. | 21640118 |
| Cytogenetic Complete Response | Stem Cell Exhaustion | In CRC tissues, SNAIL and IL-8 were coexpressed with the stem cell marker CD44 but not with CD133 or CD24. | 21640118 |
| Specialty Type - cancer | Stem Cell Exhaustion | In human CRC tissues, SNAIL regulates expression of IL-8 and other genes to induce cancer stem cell activities. | 21640118 |
| Specialty Type - cancer | Stem Cell Exhaustion | Some cancer cells have activities that are similar to those of stem cells from normal tissues, and cell dedifferentiation correlates with poor prognosis. | 21640118 |
| Specialty Type - cancer, Malignant tumor of colon, Neoplasms | Stem Cell Exhaustion | Expanded CRC colonospheres contained cells that expressed high levels of CD44 and CD166, which are markers of colon cancer stem cells, and had many features of cancer stem cells, including chemoresistance and radioresistance, the ability to initiate tumor formation, and activation of epithelial-mesenchymal transition (EMT). | 21640118 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Strategies that disrupt this pathway might be developed to block tumor formation by cancer stem cells. | 21640118 |
| Pruritus | Stem Cell Exhaustion | The patient's pruritus markedly improved within 2 cycles of chemotherapy; however, his HL relapsed and additional salvage combination chemotherapy followed by high-dose chemotherapy and autologous stem cell transplant were required. | 21644488 |
| Pericardial Effusion, CTCAE, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Differential diagnosis of pericardial effusion after stem cell transplantation in acute myeloic leukemia. | 21647784 |
| Pericardial Effusion, CTCAE, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The pathology underlying a pericardial effusion in a 24-year-old patient, who had suffered from acute myeloic leukemia 5 years previously and undergone chemotherapy followed by whole body radiation prior to allogeneic stem cell transplantation, could be identified by the careful analysis of pericardial cytology and epicardial biopsy guided by flexible pericardioscopy. | 21647784 |
| Multiple Myeloma | Stem Cell Exhaustion | Predicting hematopoietic stem cell mobilization failure in patients with multiple myeloma: a simple method using day 1 CD34+ cell yield. | 21647951 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Early and reliable prediction of the likelihood of achieving adequate stem cell collection for autologous stem cell transplantation (ASCT) in patients with multiple myeloma (MM) would improve collection efficiency, prevent unnecessary aphereses, and permit appropriate treatment alterations. | 21647951 |
| Irritation, Keratopathy, Rupture, Usual Severity Pain | Stem Cell Exhaustion | Most common complications included injection (n=13), tearing (n=10), irritation (n=9), pain (n=9), and limbal stem cell deficiency with keratopathy (n=4). | 21652078 |
| HD Term Type, Chemosensitivity | Stem Cell Exhaustion | This randomized open phase III study examines whether high-dose (HD) chemotherapy with peripheral blood stem cells (PBSCs) could improve overall survival (OS) of chemosensitive patients. | 21652583 |
| melphalan/prednisone protocol, Multiple Myeloma | Stem Cell Exhaustion | As part of the randomized MRC Myeloma IX trial, we compared an attenuated regimen of cyclophosphamide, thalidomide, and dexamethasone (CTDa; n = 426) with melphalan and prednisolone (MP; n = 423) in patients with newly diagnosed multiple myeloma ineligible for autologous stem-cell transplantation. | 21652683 |
| Renal glomerular disease, Myeloproliferative disease | Stem Cell Exhaustion | Myeloproliferative neoplasms are clonal hematopoietic stem cell disorders that can produce an undefined glomerulopathy. | 21654720 |
| Hypertensive (finding), Electrocardiogram: left ventricle hypertrophy (finding) | Stem Cell Exhaustion | Decreased circulating endothelial progenitor cell levels and function in essential hypertensive patients with electrocardiographic left ventricular hypertrophy. | 21654753 |
| Left Ventricular Hypertrophy, Hypertensive (finding), Electrocardiogram: left ventricle hypertrophy (finding) | Stem Cell Exhaustion | The aim of this study was to explore the role of circulating endothelial progenitor cells (EPCs) and endothelial apoptotic microparticles in hypertensive patients with and without electrocardiographic left ventricular hypertrophy (LVH). | 21654753 |
| Endothelial dysfunction | Stem Cell Exhaustion | Angiotensin II (Ang II) is essential for endothelial progenitor cells (EPCs) function as Ang-II-induced oxidative stress causes senescence of EPCs and endothelial dysfunction and Ang II type 1 receptor blockers increase EPCs. | 21654754 |
| Sjogrens Syndrome | Stem Cell Exhaustion | Comparison of telomere length and association with progenitor cell markers in lacrimal gland between Sjogren syndrome and non-Sjogren syndrome dry eye patients. | 21655359 |
| Sjogrens Syndrome | Stem Cell Exhaustion | The aims of this study were to 1) determine the viability of quantitative fluorescence in situ hybridization of telomeres (telo-FISH) for the assessment of telomere length in lacrimal gland in Sjogren and non- Sjogren syndrome patients; and 2) investigate the relationship between progenitor cell markers and telomere length in both groups. | 21655359 |
| Sui Chinese, Urinary Stress Incontinence | Stem Cell Exhaustion | Stem-cell injection into the degenerated external urethral sphincter is a new treatment modality for stress urinary incontinence (SUI). | 21656833 |
| Urinary Stress Incontinence | Stem Cell Exhaustion | Long-term cryopreservation of pyramidalis muscle specimens as a source of striated muscle stem cells for treatment of post-prostatectomy stress urinary incontinence. | 21656833 |
| Sui Chinese | Stem Cell Exhaustion | We examined the possibility of long-term cryopreserved pyramidalis muscle (PM) specimens as a source of striated muscle stem cells for the treatment of post-prostatectomy SUI. | 21656833 |
| Multiple Myeloma | Stem Cell Exhaustion | Predictive factors for successful salvage high-dose therapy in patients with multiple myeloma relapsing after autologous blood stem cell transplantation. | 21657961 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | For patients with relapsed or refractory multiple myeloma (MM) treated with a prior high-dose therapy (HDT) followed by autologous peripheral blood stem cell transplantation (PBSCT), the reapplication of HDT is a widely used salvage strategy. | 21657961 |
| Childhood Non-Hodgkin Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Plerixafor was recently approved for stem cell mobilization in patients who have non-Hodgkin lymphoma or multiple myeloma. | 21658654 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Of 48 patients, including 24 with myeloma and 24 with lymphoma, 47 had enough stem cells collected (> 2 x 10E6 CD34+ cells/kg) to proceed to transplant, including all 13 patients who had failed previous chemotherapy plus G-CSF mobilization and 18 patients treated with four cycles or more of lenalidomide. | 21658654 |
| Hematologic Neoplasms, Aspergillosis | Stem Cell Exhaustion | Outcome analysis of invasive aspergillosis in hematologic malignancy and hematopoietic stem cell transplant patients: the role of novel antimold azoles. | 21659609 |
| Multiple Myeloma | Stem Cell Exhaustion | A randomized trial with melphalan and prednisone versus melphalan and prednisone plus thalidomide in newly diagnosed multiple myeloma patients not eligible for autologous stem cell transplant. | 21663513 |
| Infarction | Stem Cell Exhaustion | Impact of preoperative left ventricular function and time from infarction on the long-term benefits after intramyocardial CD133(+) bone marrow stem cell transplant. | 21664627 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Preoperative left ventricular ejection fraction and time since myocardial infarction may be critical parameters for selection of patients who can benefit most from intramyocardial stem cell treatment during coronary artery bypass grafting. | 21664627 |
| Bone Marrow-Derived Cell, Dendritic Cell Sarcoma, Interdigitating, Neoplasms, histiocytic | Stem Cell Exhaustion | Histiocytic and interdigitating dendritic cell sarcomas are rare tumors originating from bone marrow-derived myeloid stem cells. | 21666687 |
| Acute leukemia, Lymphoproliferative Disorders | Stem Cell Exhaustion | Acute leukaemia (34.6%) and allogeneic stem cell transplantation (21.4%) were major host factors, together with chronic lymphoproliferative disorders (21.6%), which emerged as a new high-risk group. | 21668573 |
| Acute leukemia | Stem Cell Exhaustion | Serum galactomannan tests were more often positive (>=69%) for acute leukaemia and allogeneic stem cell transplantation than for the others (<42%; p <10(-3)). | 21668573 |
| Burn injury | Stem Cell Exhaustion | Long-term effectiveness of autologous cultured limbal stem cell grafts in patients with limbal stem cell deficiency due to chemical burns. | 21668791 |
| Burn injury, Abnormal vision, Corneal Opacity | Stem Cell Exhaustion | Chemical burns cause depletion of limbal stem cells and eventually lead to corneal opacity and visual loss. | 21668791 |
| Antilymphocyte Serum | Stem Cell Exhaustion | Optimization of immunosuppressive therapy for spinal grafting of human spinal stem cells in a rat model of ALS. | 21669047 |
| Antilymphocyte Serum | Stem Cell Exhaustion | In the present study we characterized the survival of human spinal stem cells when grafted into the lumbar spinal cords of a rodent model of ALS, SOD1 (G93A) male and female rats (60-67 days old). | 21669047 |
| Liver carcinoma | Stem Cell Exhaustion | Hepatocellular carcinoma with progenitor cell features distinguishable by the hepatic stem/progenitor cell marker NCAM. | 21669487 |
| Liver carcinoma, Hollings Cancer Center | Stem Cell Exhaustion | We analyzed hepatocellular carcinoma (HCC) with progenitor cell features using hepatic stem/progenitor cell marker neural cell adhesion molecule (NCAM). | 21669487 |
| CLU protein, human | Stem Cell Exhaustion | However, most patients with Fontaine stage IV CLI limbs had to undergo amputation even after stem cell therapy. | 21671823 |
| Cartilaginous exostosis | Stem Cell Exhaustion | Expression of the stem cell marker nestin in pre/hypertrophic chondrocytes in osteochondroma. | 21672338 |
| Pregnancy Complications, Infectious, Multiple Myeloma | Stem Cell Exhaustion | Prophylactic intravenous immunoglobulin during autologous haemopoietic stem cell transplantation for multiple myeloma is not associated with reduced infectious complications. | 21674144 |
| Pregnancy Complications, Infectious, Multiple Myeloma | Stem Cell Exhaustion | Patients with multiple myeloma undergoing autologous haemopoietic stem cell transplantation (ASCT) are at high risk for infectious complications. | 21674144 |
| Specialty Type - cancer | Stem Cell Exhaustion | Recent data showed that prostate stem cell antigen (PSCA) mRNA expression is predictive of the subsequent cancer in BPH patients treated with TURP. | 21674503 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | The introduction of plerixafor has enabled successful collection of stem cells in the majority of patients with lymphoma or myeloma in whom previous attempts at mobilization have failed. | 21674573 |
| Bacteremia | Stem Cell Exhaustion | In the retrospective survey Gram-negative bacteremic episodes occurring in a centre for hematology and stem cell transplantation were studied. | 21676672 |
| Aplastic Anemia | Stem Cell Exhaustion | Effect of stem cell source on outcomes after unrelated donor transplantation in severe aplastic anemia. | 21677312 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Breast cancer stem cell markers CD44, CD24 and ALDH1: expression distribution within intrinsic molecular subtype. | 21680574 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | The study of CD44/CD24 and ALDH1 expression is the most accurate method to identify cancer stem cells (CSC) from breast cancer populations. | 21680574 |
| Uremia | Stem Cell Exhaustion | Exposure to uremic serum induces a procalcific phenotype in human mesenchymal stem cells. | 21680902 |
| Chronic Kidney Disease, CTCAE | Stem Cell Exhaustion | The current study is based on the hypothesis that mesenchymal stem cells (MSC) constitute critical cells for procalcific extracellular matrix remodeling in patients with chronic kidney disease. | 21680902 |
| Specialty Type - cancer | Stem Cell Exhaustion | There is compelling evidence that blood-borne tissue factor that is predominantly found on circulating microparticles (MPs) plays an important role in both, cancer biology and organ and stem-cell transplantation (SCT). | 21681142 |
| Hypertrophy, Acute myocardial infarction | Stem Cell Exhaustion | Maladaptive hypertrophy after acute myocardial infarction positive effect of bone marrow-derived stem cell therapy on regional remodeling measured by cardiac MRI. | 21681619 |
| Hypertrophy | Stem Cell Exhaustion | Bone marrow-derived stem cell therapy yields smaller EDWT when compared with placebo patients suggesting a positive effect on maladaptive hypertrophy of viable myocardium. | 21681619 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study. | 21681681 |
| Chronic disease, Diabetes | Stem Cell Exhaustion | Mesenchymal stem cells (MSC) have been used in clinical trials for severe diabetes, a chronic disease with high morbidity and mortality. | 21681681 |
| physiopathological | Stem Cell Exhaustion | Relationships between vascular dysfunction, circulating endothelial progenitor cells, and psychological status in healthy subjects. | 21681866 |
| Communicable Diseases | Stem Cell Exhaustion | Vascular endothelial growth factor levels in the media from infected urine derived stem cell cultures reached a peak value on day 10 after infection. | 21683398 |
| Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Platelet recovery before allogeneic stem cell transplantation predicts posttransplantation outcomes in patients with acute myelogenous leukemia and myelodysplastic syndrome. | 21684343 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Twenty-four patients with hematologic malignancies (16 high risk) conditioned with fludarabine, cyclophosphamide, and totalbody irradiation received a CD34-selected stem cell allograft from an HLA-matched sibling along with 5 x 10(6)/kg selectively depleted donor T cells. | 21684344 |
| Medulloblastoma | Stem Cell Exhaustion | Medulloblastoma with myogenic differentiation: long-term survival in a patient treated with aggressive combination therapy and autologous stem cell transplantation. | 21688181 |
| Communicable Diseases | Stem Cell Exhaustion | Cytomegalovirus (CMV) infection and disease are important complications after hematopoietic stem cell transplant, particularly after transplant from alternative donors. | 21689774 |
| Multiple Myeloma | Stem Cell Exhaustion | Lenalidomide maintenance after nonmyeloablative allogeneic stem cell transplantation in multiple myeloma is not feasible: results of the HOVON 76 Trial. | 21690556 |
| Multiple Myeloma | Stem Cell Exhaustion | To improve the outcome of allogeneic stem cell transplantation (allo-SCT) in multiple myeloma as part of first-line treatment, we prospectively investigated the feasibility and efficacy of lenalidomide maintenance. | 21690556 |
| Multiple Myeloma | Stem Cell Exhaustion | Trends in allogeneic stem cell transplantation for multiple myeloma: a CIBMTR analysis. | 21690560 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | Small interfering RNA knockdown experiments and MTS assays were used to evaluate CPE-induced cytotoxicity against ovarian cancer stem cell lines in vitro. | 21692061 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | C.B-17/SCID mice harboring ovarian cancer stem cell xenografts were used to evaluate CPE therapeutic activity in vivo. | 21692061 |
| Malignant neoplasm of ovary, Clostridium perfringens | Stem Cell Exhaustion | Eradication of chemotherapy-resistant CD44+ human ovarian cancer stem cells in mice by intraperitoneal administration of Clostridium perfringens enterotoxin. | 21692061 |
| Neoplasms, Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Emerging evidence has suggested that the capability to sustain tumor formation, growth, and chemotherapy resistance in ovarian as well as other human malignancies exclusively resides in a small proportion of tumor cells termed cancer stem cells. | 21692061 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | During the characterization of CD44(+) ovarian cancer stem cells, we found a high expression of the genes encoding for claudin-4. | 21692061 |
| Malignant neoplasm of ovary, Clostridium perfringens | Stem Cell Exhaustion | Because this tight junction protein is the natural high-affinity receptor for Clostridium perfringens enterotoxin (CPE), we have extensively investigated the sensitivity of ovarian cancer stem cells to CPE treatment in vitro and in vivo. | 21692061 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | Real-time polymerase chain reaction and flow cytometry were used to evaluate claudin-3/-4 expression in ovarian cancer stem cells. | 21692061 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | CD44(+) ovarian cancer stem cells expressed claudin-4 gene at significantly higher levels than matched autologous CD44(-) ovarian cancer cells, and regardless of their higher resistance to chemotherapeutic agents died within 1 hour after exposure to 1.0 mg/mL of CPE in vitro. | 21692061 |
| Specialty Type - cancer | Stem Cell Exhaustion | Conversely, small-interfering RNA-mediated knockdown of claudin-3/-4 expression in CD44(+) cancer stem cells significantly protected cancer stem cells from CPE-induced cytotoxicity. | 21692061 |
| Neoplasms | Stem Cell Exhaustion | Importantly, multiple intraperitoneal administrations of sublethal doses of CPE in mice harboring xenografts of chemotherapy-resistant CD44(+) ovarian cancer stem cells had a significant inhibitory effect on tumor progression leading to the cure and/or long-term survival of all treated animals (ie, 100% reduction in tumor burden in 50% of treated mice; P < .0001). | 21692061 |
| Ulcer | Stem Cell Exhaustion | Clinically shows the high efficiency of the transplantations autologous mesenchymal stem cells in treatment of deep beam ulcers, intractable standard conservative treatment. | 21692224 |
| Radiation injury | Stem Cell Exhaustion | Found promising application of mesenchymal stem cells for treatment of severe local radiation injuries and the need to develop the best possible conditions for their use. | 21692224 |
| Specialty Type - cancer | Stem Cell Exhaustion | Patients without surgery (n = 111), with stem cell transplantation (n = 98), unknown or non-standard chemotherapy regimens (n = 94), lost to follow up (n = 66) or 'cancer status unknown' (n = 67) were excluded. | 21693006 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Correlation between the kinetics of CD3+ chimerism and the incidence of graft-versus-host disease in patients undergoing allogeneic hematopoietic stem cell transplantation. | 21693300 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease (GvHD) remains a significant complication after allogeneic hematopoietic stem cell transplantation (HSCT). | 21693300 |
| Acute GVH disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Upon univariate analysis, decreasing mixed chimerism among CD3(+) and infused CD34(+) cell numbers was significantly correlated with acute GvHD development, while the PB stem cell source, reduced-intensity conditioning regimen, and female donor sex were associated with an increased risk of chronic GvHD. | 21693300 |
| Diabetic Foot, Peripheral Arterial Diseases | Stem Cell Exhaustion | Our study suggests that stem cell therapy of diabetic foot disease is an effective therapeutic option with no adverse events for patients with severe peripheral arterial disease. | 21695925 |
| Ischemia, Diabetic Foot | Stem Cell Exhaustion | [Treatment of critical limb ischemia and diabetic foot disease by the use of autologous stem cells]. | 21695925 |
| Ischemia | Stem Cell Exhaustion | The aim of our study was to assess safety and effectiveness of therapy of critical limb ischaemia by autologous stem cells and evaluation of potential adverse events. | 21695925 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Stem cell transplantation is a potential treatment to improve left ventricular ejection fraction (LVEF) after ST elevation myocardial infarction (STEMI). | 21696072 |
| Multiple Myeloma | Stem Cell Exhaustion | Thalidomide, dexamethasone and lovastatin with autologous stem cell transplantation as a salvage immunomodulatory therapy in patients with relapsed and refractory multiple myeloma. | 21698395 |
| Neoplasms, Malignant Neoplasms | Stem Cell Exhaustion | Previous reports suggest that nestin-expressing hair follicle stem cells are undifferentiated and pluripotent, and nestin expression in some tumors indicates poor differentiation and high grade of malignancy. | 21700534 |
| Cerebral Infarction, diabetic | Stem Cell Exhaustion | Comparison of the effect of cilostazol with aspirin on circulating endothelial progenitor cells and small-dense LDL cholesterol in diabetic patients with cerebral ischemia: a randomized controlled pilot trial. | 21701082 |
| Cardiovascular Diseases | Stem Cell Exhaustion | We compared the effects of cilostazol with aspirin on circulating endothelial progenitor cells (EPCs), a surrogate marker for cardiovascular disease, and lipid metabolism in a randomized controlled trial (UMIN000000537). | 21701082 |
| Bronchiolitis Obliterans | Stem Cell Exhaustion | Endothelin-1 governs proliferation and migration of bronchoalveolar lavage-derived lung mesenchymal stem cells in bronchiolitis obliterans syndrome. | 21701423 |
| Cerebellar Diseases | Stem Cell Exhaustion | Brain stem cell and cerebellum dysfunction is thought to be due to an autoimmune mechanism. | 21702171 |
| Diabetic Retinopathy | Stem Cell Exhaustion | Erythropoietin receptor positive circulating progenitor cells and endothelial progenitor cells in patients with different stages of diabetic retinopathy. | 21703113 |
| GDC Disease Response Terminology, diabetic | Stem Cell Exhaustion | EPOR positive circulating progenitor cells (CPCs: CD34(+)) and endothelial progenitor cells (EPCs: CD34(+)KDR(+)) were assessed by flow cytometry in type 2 diabetic patients with different stages of DR. | 21703113 |
| Heart failure | Stem Cell Exhaustion | Effects of age and heart failure on human cardiac stem cell function. | 21703415 |
| Heart failure, Congestive heart failure | Stem Cell Exhaustion | Currently, it is unknown whether defects in stem cell growth and differentiation contribute to myocardial aging and chronic heart failure (CHF), and whether a compartment of functional human cardiac stem cells (hCSCs) persists in the decompensated heart. | 21703415 |
| Allogeneic Hematopoietic Stem Cell Transplantation, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Extramedullary relapse of acute myelogenous leukemia after allogeneic hematopoietic stem cell transplantation: better prognosis than systemic relapse. | 21703975 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Because of its ability to target CD20(+) lymphocytes, its use before allogeneic stem cell transplantation seemed to reduce risk of graft-vs.-host disease (GVHD) occurrence. | 21703987 |
| Lymphoproliferative Disorders | Stem Cell Exhaustion | We retrospectively analyzed the outcomes of adult patients diagnosed with CD20(+) lymphoproliferative disease undergoing allogeneic stem cell transplantation and receiving, or not receiving, rituximab up to 3 months before transplantation. | 21703987 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders primarily seen in the elderly that are characterized by ineffective hematopoiesis and a propensity to develop AML. | 21704372 |
| Communicable Diseases, Mycoses | Stem Cell Exhaustion | We investigated the efficacy of infection control measures on the frequency of fungal infection among hemato-oncologic patients undergoing stem cell transplantation during excavation and construction work of an adjacent hospital building. | 21704432 |
| B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1, BCR gene | Stem Cell Exhaustion | Intermediate dose of imatinib in combination with chemotherapy followed by allogeneic stem cell transplantation improves early outcome in paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (ALL): results of the Spanish Cooperative Group SHOP studies ALL-94, ALL-99 and ALL-2005. | 21707583 |
| Specialty Type - cancer, F9 wt Allele | Stem Cell Exhaustion | Moreover, human PTC cell line BCPAP and cancer stem cells from PTC, analyzed under hypoxic conditions, showed a hypoxia-driven increase in ER-a expression. | 21707866 |
| Acute myocardial infarction | Stem Cell Exhaustion | Enhanced mobilization of the bone marrow-derived circulating progenitor cells by intracoronary freshly isolated bone marrow cells transplantation in patients with acute myocardial infarction. | 21707914 |
| Acute myocardial infarction | Stem Cell Exhaustion | We analysed in a randomized controlled study the influence of the intracoronary autologous freshly isolated BMCs-Tx on the mobilization of bone marrow-derived circulating progenitor cells (BM-CPCs) in patients with acute myocardial infarction (AMI). | 21707914 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Aldehyde dehydrogenase 1 (ALDH1) has been characterised as a cancer stem cell marker in different types of tumours. | 21708005 |
| Ischemic stroke | Stem Cell Exhaustion | CDP-choline treatment increases circulating endothelial progenitor cells in acute ischemic stroke. | 21708065 |
| Ischemic stroke | Stem Cell Exhaustion | The increase in circulating endothelial progenitor cells (EPCs) is associated with a better outcome in patients with acute ischemic stroke. | 21708065 |
| Venoocclusive disease | Stem Cell Exhaustion | The incidence of veno-occlusive disease following allogeneic hematopoietic stem cell transplantation has diminished and the outcome improved over the last decade. | 21708110 |
| Venoocclusive disease | Stem Cell Exhaustion | The evolution of the incidence, morbidity, and mortality of veno-occlusive disease (VOD) was analyzed in 845 allogeneic hematopoietic stem cell transplantations (allo-HSCTs) performed over 24 years. | 21708110 |
| Fever, Multiple Myeloma, Adverse Event Associated with Constitutional Symptoms | Stem Cell Exhaustion | A 45 year old male presented with IgA multiple myeloma s/p (status post) autologous hematopoietic stem cell transplantation; and with a history of six weeks of fever and constitutional symptoms. | 21713352 |
| Precursor T cell lymphoblastic leukemia/lymphoblastic lymphoma | Stem Cell Exhaustion | High single-drug activity of nelarabine in relapsed T-lymphoblastic leukemia/lymphoma offers curative option with subsequent stem cell transplantation. | 21715318 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | Extramedullary gastric relapse of acute lymphoblastic leukemia following allogeneic stem cell transplant: staging with F-18 FDG PET/CT. | 21716008 |
| Gastric mucosa, Acute leukemia | Stem Cell Exhaustion | A 26-year-old man with a prior history of acute leukemia that was treated with a stem cell transplant (SCT) was referred for an F-18 FDG PET/CT to assess suspicious new gastric mucosal lesions. | 21716008 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The p53 antisense oligonucleotide cenersen has been shown to sensitize acute myeloid leukemia (AML) stem cells to DNA damaging agents. | 21717444 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Loss of p16 expression is associated with the stem cell characteristics of surface markers and therapeutic resistance in estrogen receptor-negative breast cancer. | 21717460 |
| Childhood Breast Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | The loss of p16 expression may thus reduce the response of ER-negative breast cancer cells to chemotherapy by conferring cancer stem cell-like properties. | 21717460 |
| Liver Regeneration | Stem Cell Exhaustion | The declining hepatic progenitor cell population might be one of the reasons for impaired liver regeneration in aged donors. | 21719061 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | Darbepoetin improves endothelial function and increases circulating endothelial progenitor cell number in patients with coronary artery disease. | 21719555 |
| palladium | Stem Cell Exhaustion | To date, stem cell transplantation therapy has been developed to replace lost or damaged neural cells in PD patients, in whom dopaminergic neuron cells are lost. | 21720700 |
| Medulloblastoma | Stem Cell Exhaustion | Growth-inhibitory effect of neurotrophin-3-secreting adipose tissue-derived mesenchymal stem cells on the D283-MED human medulloblastoma cell line. | 21720807 |
| Neoplasms | Stem Cell Exhaustion | The purpose of this study was to demonstrate in vitro biological effects of neurotrophins-3 (NT-3) on MBL cells and to evaluate the growth-inhibitory effect of neurotrophin-3 (NT-3)-secreting stem cells on tumor cells. | 21720807 |
| FCER2 gene | Stem Cell Exhaustion | The median event-free survival in patients treated with autologous stem cell transplantation (n = 29) was similar regardless of CD23 status, whereas the median OS (all patients) was longer in CD23(-) than in CD23(+) PCMs: not reached vs 3365 days (P = .08). | 21724429 |
| Gastrointestinal complication | Stem Cell Exhaustion | Early gastrointestinal complications of stem cell transplant - results of prospective study at IRCH, AIIMS, India. | 21724528 |
| Gastrointestinal complication | Stem Cell Exhaustion | The study was conducted with the purpose of finding clinical profile of early gastrointestinal complications of stem cell transplant at this center. | 21724528 |
| Inflammation | Stem Cell Exhaustion | Exercise training improved FMD and exercise capacity in stable CAD patients independent of the changes in inflammation, oxidative stress, or endothelial progenitor cells. | 21724681 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Therapeutic resistance of acute myeloid leukemia stem cells, enriched in the CD34(+)38(-)123(+) progenitor population, is supported by extrinsic factors such as the bone marrow niche. | 21725365 |
| Specialty Type - cancer, Adult Glioblastoma, Neoplasms, Hypoxia | Stem Cell Exhaustion | We recently described a three-layer concentric model of a glioblastoma (GBM) related to a specific distribution of molecular and phenotypic characteristics driven by the intratumoral hypoxic gradient in which the cancer stem cells niche is located in the hypoxic necrotic core of the tumour. | 21725802 |
| Mucositis following radiation therapy | Stem Cell Exhaustion | This study seeks to investigate the use of extra-orally applied near-infrared phototherapy for the reduction of oral pain secondary to chemotherapy- and radiation therapy-induced mucositis in adult and pediatric hematopoietic stem cell transplant (HSCT) patients. | 21725826 |
| Multiple Myeloma | Stem Cell Exhaustion | Tandem autologous/reduced-intensity conditioning allogeneic stem-cell transplantation versus autologous transplantation in myeloma: long-term follow-up. | 21730266 |
| Multiple Myeloma | Stem Cell Exhaustion | Results of allogeneic stem-cell transplantation (allo) in myeloma are controversial. | 21730266 |
| Multiple Myeloma | Stem Cell Exhaustion | In this trial autologous stem-cell transplantation (auto) followed by reduced-intensity conditioning matched sibling donor allo (auto-allo) was compared with auto only in previously untreated multiple myeloma. | 21730266 |
| Mantle cell lymphoma, Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | Stem Cell Exhaustion | Mantle cell lymphoma international prognostic index but not pretransplantation induction regimen predicts survival for patients with mantle-cell lymphoma receiving high-dose therapy and autologous stem-cell transplantation. | 21730271 |
| Medial collateral ligament, Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | Stem Cell Exhaustion | High-dose therapy (HDT) and autologous stem-cell transplantation (ASCT) are frequently used in an attempt to improve outcome in patients with mantle-cell lymphoma (MCL); however, the importance of intensive induction regimens before transplantation is unknown. | 21730271 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Busulfan is a bifunctional alkylating agent widely used in pretransplant conditioning regimens in patients undergoing stem cell transplantation for hematologic malignancies. | 21730282 |
| Sarcoma | Stem Cell Exhaustion | Human sarcomas have been modeled in mice by expression of specific fusion genes in mesenchymal stem cells (MSCs). | 21732477 |
| Communicable Diseases, Acute leukemia | Stem Cell Exhaustion | Comparison of the occurrence of mold infection among patients receiving chemotherapy for acute leukemia versus patients undergoing stem cell transplantation. | 21732981 |
| PAFAH1B1 wt Allele, Acute leukemia | Stem Cell Exhaustion | We performed a single-center retrospective analysis examining both adult patients treated with chemotherapy for acute leukemia or MDS and patients undergoing allogeneic or autologous stem cell transplantation (SCT) between June 2007 and August 2009. | 21732981 |
| Pulmonary arterial hypertension | Stem Cell Exhaustion | Design and validation of an endothelial progenitor cell capture chip and its application in patients with pulmonary arterial hypertension. | 21735044 |
| Enlargement procedure, Paraproteinemias | Stem Cell Exhaustion | After high dose chemotherapy with autologous peripheral stem cell transplantation, his clinical manifestations, IgG lambda type monoclonal proteinemia, and elevated level of serum VEGF were improved, whereas diffuse enlargement of the pancreas did not change. | 21735734 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Idiotype immunization following high-dose therapy and autologous stem cell transplantation for non-Hodgkin lymphoma. | 21736867 |
| Parkinson Disease | Stem Cell Exhaustion | Comparison of endothelial progenitor cells in Parkinson's disease patients treated with levodopa and levodopa/COMT inhibitor. | 21738693 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Durable event-free survival following autologous stem cell transplant for relapsed or refractory follicular lymphoma: positive impact of recent rituximab exposure and low-risk Follicular Lymphoma International Prognostic Index score. | 21740097 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Published studies have provided conflicting results regarding the curative potential of high dose chemotherapy and autologous stem cell transplant (HDT/ASCT) for follicular lymphoma (FL). | 21740097 |
| MYELODYSPLASTIC SYNDROME, Therapy-Related Acute Myeloid Leukemia | Stem Cell Exhaustion | Allogeneic stem cell transplantation in therapy-related acute myeloid leukemia and myelodysplastic syndromes: impact of patient characteristics and timing of transplant. | 21740299 |
| Therapy-related myelodysplastic syndrome, MYELODYSPLASTIC SYNDROME, Therapy-Related Acute Myeloid Leukemia | Stem Cell Exhaustion | Patients with therapy-related acute myeloid leukemia (t-AML) and myelodysplastic syndromes (t-MDS) have poor survival and high non-relapse mortality (NRM) after allogeneic stem cell transplantation. | 21740299 |
| Acute myocardial infarction | Stem Cell Exhaustion | Endothelin-1 levels predict endothelial progenitor cell mobilization after acute myocardial infarction. | 21741393 |
| Acute myocardial infarction | Stem Cell Exhaustion | Endothelin-1 (ET-1), circulating endothelial cells (CEC) and endothelial progenitor cells (EPC) are well-known modulators of endothelial function with important cardiac effects after an acute myocardial infarction. | 21741393 |
| Adenoviruses, Human | Stem Cell Exhaustion | High lethality of human adenovirus disease in adult allogeneic stem cell transplant recipients with high adenoviral blood load. | 21742548 |
| Infection | Stem Cell Exhaustion | Human adenoviruses (HAdV) can cause disseminated disease as a severe complication after haematopoietic stem cell transplantation (SCT) and may originate from the reactivation of latent infections. | 21742548 |
| leukemia, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Role of HCT-comorbidity index, age and disease status at transplantation in predicting survival and non-relapse mortality in patients with myelodysplasia and leukemia undergoing reduced-intensity-conditioning hemopoeitic progenitor cell transplantation. | 21743502 |
| Multiple Myeloma | Stem Cell Exhaustion | Treatment of multiple myeloma patients with autologous stem cell transplantation - a fresh analysis. | 21744324 |
| Multiple Myeloma | Stem Cell Exhaustion | High dose chemotherapy followed by autologous stem cell transplantation (ASCT), first introduced in the mid-1980s, is now considered the standard therapy for almost all patients with multiple myeloma, because it prolongs overall survival and disease free survival. | 21744324 |
| Multiple Myeloma | Stem Cell Exhaustion | The level of minimal residual disease in the bone marrow of patients with multiple myeloma before high-dose therapy and autologous blood stem cell transplantation is an independent predictive parameter. | 21745451 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Corticosteroid refractory graft-versus-host disease (GVHD) is one of the major challenges in the management of allogeneic stem cell transplant recipients. | 21745454 |
| Childhood Breast Carcinoma, S100A4 protein, human | Stem Cell Exhaustion | The results of this study suggest that, following malignant transformation, breast cancer stem/progenitor cells retain their stem cell functions and relative frequencies. | 21748247 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | The process by which breast cancer stem cells arise is unknown. | 21748247 |
| Neoplasms | Stem Cell Exhaustion | Genetic mutations in the PIK/AKT pathway were found in 73% of the tumors' stem cells, specifically within two subpopulations. | 21748247 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | In this study, we collected and compared benign and malignant breast stem/progenitor cells to determine whether specific genetic abnormalities occur in breast cancer stem/progenitor cells within the human body. | 21748247 |
| Pneumonia | Stem Cell Exhaustion | Use of a novel virus detection assay to identify coronavirus HKU1 in the lungs of a hematopoietic stem cell transplant recipient with fatal pneumonia. | 21749586 |
| Lupus Erythematosus, Pulmonary Infiltrate, Hypoxemia | Stem Cell Exhaustion | A 38-year-old female patient with systemic lupus erythematosus presented with pulmonary infiltrates and hypoxemia for several months following immunodepleting autologous hematopoietic stem cell transplantation. | 21749586 |
| Aspergillosis | Stem Cell Exhaustion | Low incidence of invasive aspergillosis in allogeneic stem cell transplant recipients receiving amphotericin B inhalation prophylaxis. | 21749589 |
| Aspergillosis | Stem Cell Exhaustion | In this retrospective study we evaluated the impact of amphotericin B (AmB) deoxycholate inhalation prophylaxis on invasive aspergillosis (IA) in 611 allogeneic stem cell transplant (alloSCT) recipients and their tolerance of the inhalations. | 21749589 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Autologous stem cell transplantation with thiotepa, busulfan, and cyclophosphamide (TBC) conditioning in patients with CNS involvement by non-Hodgkin lymphoma. | 21749848 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Mycophenolate mofetil (MMF) has been widely used for prophylaxis against graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transplantation (allo-SCT). | 21751082 |
| Endometrial Hyperplasia, Carcinoma, Endometrioid | Stem Cell Exhaustion | Firstly to examine the expression characteristics of Musashi (Msi)-1 in fetal endometrium, reproductive normal endometrium, endometrial hyperplasia and endometrioid adenocarcinoma, next, to focus on exploring the possibility that Msi-1 serves as a marker of the endometrial stem cells in-situ. | 21751144 |
| Adenocarcinoma | Stem Cell Exhaustion | The high expression of Msi-1 in fetal endometrium and endometrioid adenocarcinoma suggests that Msi-1 positive cells have several characteristics of stem cells, such as high proliferative potentiality and multipotency. | 21751144 |
| Mantle cell lymphoma | Stem Cell Exhaustion | High-dose cyclophosphamide and rituximab without stem cell transplant: a feasibility study for low grade B-cell, transformed and mantle cell lymphomas. | 21756035 |
| Neoplasms | Stem Cell Exhaustion | Relapse after autologous stem cell transplant for low grade B-cell lymphoma is common secondary to ineffective conditioning and/or tumor autograft contamination. | 21756035 |
| Lymphoma | Stem Cell Exhaustion | We investigated high-dose cyclophosphamide and rituximab without stem cell rescue as first-line or salvage therapy in lymphomas. | 21756035 |
| Hemorrhagic cystitis | Stem Cell Exhaustion | Clinical profile and outcome of urotheliotropic viral haemorrhagic cystitis following haematopoietic stem cell transplantation: a 7-year tertiary centre analysis. | 21756537 |
| CLTC gene, Hemorrhagic cystitis | Stem Cell Exhaustion | Viral haemorrhagic cystitis (HC) is a significant complication after haematopoietic stem cell transplantation (HSCT), with a potential for major morbidity. | 21756537 |
| Stanford Cancer Institute, Ulcer | Stem Cell Exhaustion | Prompted by encouraging results obtained using bone marrow stem cells to treat several diseases including chronic wounds, this study examines the use of autologous stem cells from bone marrow to promote the healing of pressure ulcers in patients with SCI. | 21756569 |
| Breast Carcinoma | Stem Cell Exhaustion | Hematopoietic progenitor cells (HPCs) in node-negative invasive breast carcinomas: Immunohistochemical analysis and clinico-pathological correlations. | 21757299 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Using immunohistochemistry, we investigated 603 negative lymph nodes from 51 patients affected by invasive breast cancer (BC) to recognize bone marrow-derived hematopoietic progenitor cells (HPCs). | 21757299 |
| Endothelial dysfunction, Uremia | Stem Cell Exhaustion | Vitamin D deficiency is associated with endothelial dysfunction in uremic patients, possibly by the impairment in the number and function of endothelial progenitor cells (EPCs). | 21757895 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Gene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML. | 21760593 |
| Coronary artery | Stem Cell Exhaustion | To assess the safety and efficacy of the Genous(tm) endothelial progenitor cell (EPC) capturing stent in conjunction with HmG-CoA-reductase inhibitors (statins) to stimulate EPC recruitment, in the treatment of patients with de novo coronary artery lesions. | 21763653 |
| Secondary to | Stem Cell Exhaustion | Secondary MGUS was more common in patients after stem cell transplantation than in those who had not undergone such treatment (22.7% vs 1.6%, P < .001). | 21765020 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Treatment of FLT3-ITD-positive acute myeloid leukemia relapsing after allogeneic stem cell transplantation with sorafenib. | 21767516 |
| FLT3 Internal Tandem Duplication, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Patients with acute myeloid leukemia (AML) and internal tandem duplication of FMS-like tyrosine kinase receptor-3 gene (FLT3-ITD) mutation have poor prognoses and are often treated with allogeneic hematopoietic stem cell transplantation (HSCT). | 21767516 |
| Hair follicle structure | Stem Cell Exhaustion | Whether the change is triggered at the level of stem cell differentiation, by cytokine or hormonal influences, gene expression during hair follicle development, a combination of all of these, or an unknown cause is a question that remains to be answered. | 21768446 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | High-dose chemotherapy with autologous hematopoietic stem-cell transplantation in metastatic breast cancer: overview of six randomized trials. | 21768454 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Substantial interest in supporting high-dose chemotherapy with bone marrow or autologous hematopoietic stem-cell transplantation in the 1980s and 1990s led to the initiation of randomized trials to evaluate its effect in the treatment of metastatic breast cancer. | 21768454 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | We identified six randomized trials in metastatic breast cancer that evaluated high doses of chemotherapy with transplant support versus a control regimen without stem-cell support. | 21768454 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | High-dose chemotherapy with autologous stem-cell support as adjuvant therapy in breast cancer: overview of 15 randomized trials. | 21768471 |
| Primary malignant neoplasm | Stem Cell Exhaustion | Adjuvant high-dose chemotherapy (HDC) with autologous hematopoietic stem-cell transplantation (AHST) for high-risk primary breast cancer has not been shown to prolong survival. | 21768471 |
| Abdominal Pain, BCR gene, primary disorders | Stem Cell Exhaustion | We report a case of a 4-year-old African-American male with a previous history of ALL and hematopoietic stem cell transplant who presented with decreased arm movement and abdominal pain with relapse of primary disease into the brachial plexus and pancreas. | 21768888 |
| Glioblastoma Multiforme Pathway, Glioma | Stem Cell Exhaustion | Expression of glioma stem cell marker CD133 and O6-methylguanine-DNA methyltransferase is associated with resistance to radiotherapy in gliomas. | 21769436 |
| Glioblastoma Multiforme Pathway, Malignant Glioma | Stem Cell Exhaustion | In the present study, we investigated the prognostic roles of the O6-methylguanine-DNA methyltransferase (MGMT) gene methylation status, the protein profiles of MGMT, and the glioma stem cell (GSC) marker CD133 in malignant glioma resistance to radiotherapy. | 21769436 |
| Systemic Scleroderma, Sample Size Calculation | Stem Cell Exhaustion | To determine the gene expression profile of endothelial cells derived from the endothelial progenitor cells (EPCs) of patients with systemic sclerosis (SSc). | 21769840 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplantation in multiple myeloma and lymphoma: an analysis of factors influencing stem cell collection and hematological recovery. | 21779930 |
| Childhood Non-Hodgkin Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Autologous stem cell transplantation is standard treatment for newly diagnosed younger patients with multiple myeloma and for relapsed or refractory Hodgkin or non-Hodgkin lymphoma. | 21779930 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Multiple myeloma patients were older than lymphoma patients but received stem cell transplant up-front as opposed to second line therapy for other patient groups. | 21779930 |
| Multiple Myeloma | Stem Cell Exhaustion | Feasibility of autologous hematopoietic stem cell transplant in patients aged >=70 years with multiple myeloma. | 21780997 |
| Multiple Myeloma | Stem Cell Exhaustion | Abstract We retrospectively analyzed the outcomes of all consecutive patients with myeloma (n = 84) aged >=70 years who had received autologous hematopoietic stem cell transplant (auto HCT) between July 1999 and June 2010 at our institution. | 21780997 |
| Hematological Disease | Stem Cell Exhaustion | This retrospective multicenter report assessed the outcome of 600 patients with hematologic diseases older than 60 years who received reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (allo-HSCT), with the specific aim to compare outcomes of patients between 60 and 65 years old (N = 493) with those older than 65 years (N = 107). | 21781949 |
| Anterior myocardial infarction | Stem Cell Exhaustion | Safety and feasibility of combined granulocyte colony stimulating factor and erythropoetin based-stem cell therapy using intracoronary infusion of peripheral blood stem cells in patients with recent anterior myocardial infarction: one-year follow-up of a phase 1 study. | 21785174 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | to assess the safety and feasibility of combined granulocyte colony-stimulating factor (G-CSF) and erythropoietin (EPO) based intracoronary peripheral blood stem cells (PBSCs) therapy in patients with recent myocardial infarction (RMI) who had successful reperfusion therapy with drug-eluting stent. | 21785174 |
| melanoma | Stem Cell Exhaustion | Embryonic stem-cell-preconditioned microenvironment induces loss of cancer cell properties in human melanoma cells. | 21787378 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells (CSCs) play an important role in the recurrence and drug resistance of cancer. | 21787767 |
| Neoplasms | Stem Cell Exhaustion | The tumors that arose from purified CD117(+)Lineage(-) cells reproduced the original tumor heterogeneity and could be serially generated, demonstrating the ability to self-renew and to differentiate, two defining properties of stem cells. | 21787767 |
| Cytopenia, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Myelodysplastic syndromes encompass a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis, refractory cytopenia and a tendency to progress toward acute myeloid leukemia. | 21789382 |
| Chronic myeloproliferative disorder, Polycythemia Vera | Stem Cell Exhaustion | Polycythemia vera (PV) is a clonal myeloproliferative neoplasm (MPN) of hematopoietic stem cells. | 21790864 |
| Multiple Myeloma, Lymphoma, Morular Metaplasia of the Endometrium | Stem Cell Exhaustion | We evaluated the safety and efficacy of plerixafor, subsequent to disease-specific chemotherapy followed by granulocyte-colony stimulating factor (G-CSF), in 37 multiple myeloma (MM) or lymphoma patients, who were candidates for autologous stem cell transplantation (ASCT) predicted as poor mobilizers (PMs). | 21791194 |
| Lymphoma | Stem Cell Exhaustion | Of the 27 patients rescued with plerixafor, 24 (13 MM, 11 lymphoma) have been transplanted with plerixafor-mobilized peripheral blood stem cells, showing a rapid and durable hematologic recovery. | 21791194 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Leukemic stem cell persistence in chronic myeloid leukemia patients with sustained undetectable molecular residual disease. | 21791426 |
| leukemia | Stem Cell Exhaustion | It remains unclear whether these patients are definitively cured of their leukemia or whether leukemic stem cells (LSCs) persist in their BM. | 21791426 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | From a total cohort (n = 242) of patients surviving more than 100 days after hematopoietic stem cell transplantation, 181 (75% of those at risk) had some manifestations of graft-versus-host disease after day 100. | 21791465 |
| Chronic graft-versus-host disease | Stem Cell Exhaustion | We aimed to study the association of the proposed chronic graft-versus-host disease classification and global severity with transplantation outcomes among a consecutive series of patients who received pharmacokinetically-targeted doses of intravenous busulfan and fludarabine conditioning followed by transplantation of allogeneic peripheral blood stem cells. | 21791465 |
| Endothelium | Stem Cell Exhaustion | The circulating endothelial progenitor cell (EPC) plays an important role in postnatal vasculogenesis and reduction of endothelial injury. | 21793037 |
| Cerebral Aneurysm | Stem Cell Exhaustion | Changes and function of circulating endothelial progenitor cells in patients with cerebral aneurysm. | 21793037 |
| Morular Metaplasia of the Endometrium, Malignant Neoplasms | Stem Cell Exhaustion | We calculated standardized incidence rates (SIRs) for all subsequent hematologic and nonhematologic malignancies for MM patients diagnosed before/after 1995 (introduction of high-dose melphalan/autologous stem cell transplantation [HDM-ASCT]) and 2000 (introduction of immunomodulatory drugs [IMiDs]), respectively. | 21795746 |
| Specialty Type - cancer | Stem Cell Exhaustion | CD133 is known to be a cancer stem cell (CSC) marker. | 21798073 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | We report the case of a 24-year-old patient who underwent a duodenal biopsy due to the suspicion of graft-versus-host disease following allogeneic stem cell transplantation 3 months previously. | 21800189 |
| Concomitant Medication Submission Domain | Stem Cell Exhaustion | The identification of cells with properties of retinal progenitor cells (RPCs) in the adult human ciliary margin (CM) prompted a number of studies of their proliferative and differentiation potential. | 21801333 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We performed a phase I study of the combination of clofarabine plus melphalan as a reduced-intensity conditioning regimen for allogeneic stem cell transplantation in patients with acute myelogenous leukemia. | 21801703 |
| Ductal Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Clinicopathologic correlation of cancer stem cell markers CD44, CD24, VEGF and HIF-1a in ductal carcinoma in situ and invasive ductal carcinoma of breast: an immunohistochemistry-based pilot study. | 21802218 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | CD24(-/low)CD44(+) cells have been identified as putative cancer stem cells (CSCs) in breast cancer. | 21802218 |
| Liver Dysfunction | Stem Cell Exhaustion | The role of ERCP in evaluating patients with hepatobiliary dysfunction after hematopoietic stem cell transplantation (HSCT) has not been well-defined. | 21802682 |
| Malignant melanoma of conjunctiva, Ocular Cicatricial Pemphigoid, Stevens-Johnson Syndrome | Stem Cell Exhaustion | Seven patients (7 eyes) with total limbal stem cell deficiency caused by chemical burn (4 eyes), Stevens-Johnson syndrome / toxic epidermal necrolysis (1 eye), ocular cicatricial pemphigoid (1 eye), and multiple cryotherapies and application of mitomycin C for conjunctival melanoma (1 eye) were enrolled in this study. | 21803325 |
| Hematologic Neoplasms, Cardiotoxicity | Stem Cell Exhaustion | The current treatment of hematologic malignancies includes diverse potentially cardiotoxic chemotherapy agents, including high-dose myeloablative regimens used in autologous hematopoietic stem cell transplantation (HSCT). | 21807325 |
| Degenerative polyarthritis, Osteopenia | Stem Cell Exhaustion | Aging is associated with bone loss and degenerative joint diseases, in which the aging of bone marrow-derived mesenchymal stem cell (bmMSC)[1] may play an important role. | 21808097 |
| Disorder of skeletal system | Stem Cell Exhaustion | Gene expression profiling suggests a pathological role of human bone marrow-derived mesenchymal stem cells in aging-related skeletal diseases. | 21808097 |
| Globoid cell leukodystrophy | Stem Cell Exhaustion | Neural stem cell gene therapy ameliorates pathology and function in a mouse model of globoid cell leukodystrophy. | 21809420 |
| Globoid cell leukodystrophy | Stem Cell Exhaustion | Murine neural stem cells (mNSCs), either naive or genetically modified to express supranormal levels of b-galactocerebrosidase (GALC), were transplanted into the brain of Twitcher mice, a murine model of globoid cell leukodystrophy, a severe sphingolipidosis. | 21809420 |
| Peripheral Arterial Diseases | Stem Cell Exhaustion | Controlled-release basic fibroblast growth factor for peripheral artery disease: comparison with autologous bone marrow-derived stem cell transfer. | 21810028 |
| Hemorrhagic cystitis | Stem Cell Exhaustion | Different risk factors related to adenovirus- or BK virus-associated hemorrhagic cystitis following allogeneic stem cell transplantation. | 21810401 |
| CLTC gene, Hemorrhagic cystitis | Stem Cell Exhaustion | Virus-associated hemorrhagic cystitis (HC) is a major cause of morbidity and mortality following allogeneic hematopoietic stem cell transplantation (HSCT). | 21810401 |
| Acute Undifferentiated Leukemia | Stem Cell Exhaustion | Further, corresponding to the morphological changes of nucleolus in number and size, these highly proliferating SSEA1 cells demonstrated coexpression of either D2-40 or the mesodermal marker Scl (stem cell leukemia), brachyury, and Flk-1 (vascular endothelial growth factor-2), respectively, indicative of the neoplasmtic transformation into the stromal or vascular cells. | 21811099 |
| Antilymphocyte Serum | Stem Cell Exhaustion | As pharmacological therapies have failed to provide sufficient neuroprotective effects in ALS, transplantation of stem or progenitor cells is considered a promising treatment strategy. | 21812628 |
| Antilymphocyte Serum | Stem Cell Exhaustion | We present a 63-year-old male patient suffering from ALS who underwent intramedullary thoracic spinal cord implantation of human CD34(+) umbilical cord-derived haematopoietic progenitor cells with a three-year follow up after transplantation. | 21812628 |
| Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | Efficacy of large doses of IL-2-activated human leukocyte antigen haploidentical peripheral blood stem cells on refractory metastatic renal cell carcinoma. | 21812652 |
| Refractory Cytopenia of Childhood | Stem Cell Exhaustion | The aim of this article was to evaluate the clinical efficacy of the infusion of a high dose of interleukin (IL)-2-activated allogeneic haploidentical peripheral blood stem cells (haplo-PBSCs) in patients with advanced intractable RCC. | 21812652 |
| Aplastic Anemia, Hematopoietic | Stem Cell Exhaustion | In severe acquired aplastic anemia, hematopoietic failure is the result of immune-mediated destruction of bone marrow stem and progenitor cells. | 21812672 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Clinical outcomes of patients with plasma cell leukemia in the era of novel therapies and hematopoietic stem cell transplantation strategies: a single-institution experience. | 21813352 |
| Engraftment syndrome | Stem Cell Exhaustion | Cyclophosphamide and prednisone induction followed by cyclophosphamide mobilization effectively decreases the incidence of engraftment syndrome in patients with POEMS syndrome who undergo stem cell transplantation. | 21815185 |
| Specialty Type - cancer | Stem Cell Exhaustion | High-dose chemotherapy with autologous stem cell transplantation (ASCT) can achieve excellent clinical responses in patients with POEMS syndrome (Jimenez Zepeda et al., Blood 2010;116:2403; Gertz et al., Am J Hematol 2005;79:319-328; Gherardi et al., Ann Neurol 1994;35:501-505; Gattinoni et al., Nat Rev Immunol 2006;6:383-393; Salem et al., J Immunol 2009;182:2030-2040; Salem et al., Cancer Immunol Immunother 2010;59:341-353; Salem et al., Cell Immunol 2010;261:134-143). | 21815185 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Further studies should focus on alternative approaches to using proteasome inhibitors in the treatment of CML, such as in combination with tyrosine kinase inhibitors (TKIs) or as a strategy to eradicate leukemic stem cells. | 21816374 |
| Conn Syndrome | Stem Cell Exhaustion | Endothelial progenitor cells in primary aldosteronism: a biomarker of severity for aldosterone vasculopathy and prognosis. | 21816781 |
| Arterial Stiffness | Stem Cell Exhaustion | Our objective was to investigate the number and function of endothelial progenitor cells (EPC) in PA and the relationship with arterial stiffness and disease progression. | 21816781 |
| Lymphoma | Stem Cell Exhaustion | BeEAM (bendamustine, etoposide, cytarabine, melphalan) before autologous stem cell transplantation is safe and effective for resistant/relapsed lymphoma patients. | 21816830 |
| Lymphoma | Stem Cell Exhaustion | We designed a phase 1-2 study to evaluate the safety and the efficacy of increasing doses of bendamustine (160 mg/m2, 180 mg/m2, and 200 mg/m2 given on days -7 and -6) coupled with fixed doses of etoposide, cytarabine, and melphalan (BeEAM regimen) as the conditioning regimen to autologous stem cell transplantation for resistant/relapsed lymphoma patients. | 21816830 |
| Inflammatory Bowel Diseases, Dysplasia | Stem Cell Exhaustion | Dysplastic lesions in inflammatory bowel disease show increased positivity for the stem cell marker aldehyde dehydrogenase. | 21820149 |
| Inflammatory Bowel Diseases, Specialty Type - cancer, Dysplasia | Stem Cell Exhaustion | To this end, we studied the expression of the cancer stem cell marker aldehyde dehydrogenase to determine whether expression is increased in dysplastic lesions arising in inflammatory bowel disease. | 21820149 |
| Inflammatory Bowel Diseases, Specialty Type - cancer, Dysplasia | Stem Cell Exhaustion | Our findings support the hypothesis that dysplasia in inflammatory bowel disease is associated with increased aldehyde dehydrogenase positivity, which supports the cancer stem cell hypothesis. | 21820149 |
| Multiple Myeloma | Stem Cell Exhaustion | Allogeneic stem cell transplantation in multiple myeloma relapsed after autograft: a multicenter retrospective study based on donor availability. | 21820394 |
| Multiple Myeloma | Stem Cell Exhaustion | Allogeneic stem cell transplantation (allo-SCT) using reduced-intensity conditioning (RIC) is a feasible procedure in selected patients with relapsed multiple myeloma (MM), but its efficacy remains a matter of debate. | 21820394 |
| Neoplasms | Stem Cell Exhaustion | We will also review data about stem cells, tumor initiating cells and dormancy state. | 21826967 |
| Damage | Stem Cell Exhaustion | Marrow damage from chemo- and radiation therapies has been suggested to affect quality and quantity of hematopoietic stem cell (HSC) products. | 21827503 |
| Amyloidosis | Stem Cell Exhaustion | Outcome of AL amyloidosis after high-dose melphalan and autologous stem cell transplantation: long-term results in a series of 421 patients. | 21828140 |
| Amyloidosis | Stem Cell Exhaustion | Previous studies have suggested that, in patients with AL amyloidosis treated with high-dose melphalan and autologous stem-cell transplantation (HDM/SCT), the greatest benefit is seen in those patients achieving a hematologic complete response (CR). | 21828140 |
| Diabetes, Myocardial Ischemia | Stem Cell Exhaustion | Impaired mobilization of CD133(+) bone marrow-derived circulating progenitor cells with an increased number of diseased coronary arteries in ischemic heart disease patients with diabetes. | 21828932 |
| Myocardial Ischemia | Stem Cell Exhaustion | The influence of the number of diseased coronary arteries on the mobilization of CD133/45(+) bone marrow-derived circulating progenitor cells (BM-CPCs) in peripheral blood (PB) in patients with ischemic heart disease (IHD) was analyzed. | 21828932 |
| Aggressive course, Specialty Type - cancer | Stem Cell Exhaustion | Podocalyxin-like 1 (PODXL) is a cell-adhesion glycoprotein and stem cell marker that has been associated with an aggressive tumour phenotype and poor prognosis in several forms of cancer. | 21829192 |
| Carcinogenesis | Stem Cell Exhaustion | Sequential expression of putative stem cell markers in gastric carcinogenesis. | 21829201 |
| Decreased platelet count | Stem Cell Exhaustion | Prognostic significance of delayed thrombocytopenia after allogeneic stem cell transplant. | 21830231 |
| Neoplasms | Stem Cell Exhaustion | It is recognized as a rare but life-threatening complication of organ transplantation, tumor eradication chemotherapy and is associated with haematopoietic stem cell transplantation (SCT). | 21830430 |
| B-Cell Lymphomas | Stem Cell Exhaustion | A prospective phase II study of RICE re-induction, then high-dose fludarabine and busulfan, followed by autologous or allogeneic blood stem cell transplantation for indolent b-cell lymphoma. | 21831743 |
| Lymphoma | Stem Cell Exhaustion | Optimal high dose conditioning and relative roles of autologous stem cell transplantation (autoSCT) or allogeneic (alloSCT) for indolent lymphoma are uncertain. | 21831743 |
| SERPINB3 wt Allele, Leukoplakia, Squamous cell carcinoma | Stem Cell Exhaustion | This study examined immunohistochemical expression of DNp63, a keratinocyte stem cell marker, in oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC) and then to elucidate usefulness of DNp63 as a marker for diagnosis and prognosis. | 21833468 |
| Childhood Breast Carcinoma, Neoplasms, Secondary Neoplasm, Triple Negative Breast Neoplasms | Stem Cell Exhaustion | We determined that patients with triple-negative tumors had significantly higher incidence of recurrence or distant metastasis associated with increased frequency of breast cancer stem cell phenotypes compared with those with non-triple-negative tumors. | 21835433 |
| Neoplasms, Childhood Breast Carcinoma, Primary Neoplasm | Stem Cell Exhaustion | Preclinical studies in FVBN202 transgenic mice confirmed these findings by showing that relapsed tumors were triple negative and had significantly higher frequency of breast cancer stem cells compared with their related primary tumors. | 21835433 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | The importance of CD44(+)/CD24(-/low) (stem/progenitor cell-phenotype) in breast cancer patients has also been appreciated. | 21835433 |
| Breast Carcinoma, Specialty Type - cancer, Triple-Negative Breast Cancer Finding | Stem Cell Exhaustion | CD44(+)/CD24(-/low) cancer stem/progenitor cells are more abundant in triple-negative invasive breast carcinoma phenotype and are associated with poor outcome. | 21835433 |
| Histogenic Process | Stem Cell Exhaustion | Histogenesis remains controversial, although the consensus tends toward a pluripotent stem cell of the middle ear mucosa as the origin of the lesion. | 21838097 |
| Neoplasms, Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | CD44(+) /CD24(-) tumor cells are reported to contain cancer stem cells in breast cancer. | 21838786 |
| Hyperlipidemia | Stem Cell Exhaustion | Hyperlipidemia and statin use after allogeneic hematopoietic stem cell transplantation. | 21839706 |
| Cardiac complication | Stem Cell Exhaustion | An increased incidence of cardiovascular complications has been documented in recipients of allogeneic hematopoietic stem cell transplantation (HSCT). | 21839706 |
| Graft-vs-Host Disease, Enterovirus Gastroenteritis, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We present a 43-year-old individual with large-volume stool output Norovirus acute gastroenteritis in the setting of relapsed refractory acute myelogenous leukemia, hematopoietic stem cell transplantation, and biopsy-proven cutaneous and pulmonary graft-versus-host disease. | 21839773 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Patients with hematologic malignancies not in remission before allogeneic hematopoietic stem cell transplantation (HSCT) have a poor prognosis. | 21841163 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Complete remission was achieved in 80% of all patients by day +30 and in 100% of AML patients without prior hematopoietic stem cell transplantation. | 21841163 |
| Myxoma | Stem Cell Exhaustion | The potential origin from pluripotent mesenchymal cells or from seeded stem cells is hypothesized for glandular differentiation in myxomas. | 21843055 |
| Neutropenia | Stem Cell Exhaustion | Disease-specific factors including hematological diagnosis, neutropenia, remission status, prior stem cell transplant, time from diagnosis to admission and degree of prior treatment were not predictive. | 21846185 |
| methyldopa | Stem Cell Exhaustion | Neural stem/progenitor cells circulating in peripheral blood of patients with neovascular form of AMD: a novel view on pathophysiology. | 21847578 |
| methyldopa | Stem Cell Exhaustion | Our findings suggest that neural progenitor cells, together with low SDF-1 concentrations, may play a considerable role in the process of AMD progression. | 21847578 |
| Pure Red-Cell Aplasia, Hemolysis (biological function) | Stem Cell Exhaustion | Major ABO mismatch in hematopoietic progenitor cell transplantation (HPCT) is associated with a range of immunohematologic consequences including progenitor cell infusion (PCI)-related hemolysis, delayed red blood cell engraftment, and pure red cell aplasia (PRCA). | 21848968 |
| Bone necrosis | Stem Cell Exhaustion | Autologous bone marrow stem cell intralesional transplantation repairing bisphosphonate related osteonecrosis of the jaw. | 21849044 |
| Bone necrosis | Stem Cell Exhaustion | Before the injection of stem cells into the osteonecrosis, the patient underwent surgical toilet, local anesthesia was done and spongostan was applied as a carrier of stem cells suspension in the bone cavity, then 4 ml of stem cells suspension and 1 ml of patient's activated platelet-rich plasma were injected in the lesion of BRONJ. | 21849044 |
| Zygomycosis | Stem Cell Exhaustion | Mucormycosis has been reported to be occurring more frequently in hematopoietic stem cell transplant (HSCT) recipients in recent years. | 21851872 |
| Restenosis | Stem Cell Exhaustion | 1-year outcome of TRIAS HR (TRI-stent adjudication study-high risk of restenosis) a multicenter, randomized trial comparing genous endothelial progenitor cell capturing stents with drug-eluting stents. | 21851905 |
| Cardiac Death, Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | This study sought to demonstrate the noninferiority of endothelial progenitor cell capturing stents (ECS) relative to drug-eluting stents (DES) regarding target lesion failure (TLF) and the composite of cardiac death, myocardial infarction, and target lesion repeat revascularization within 1 year. | 21851905 |
| Graft-vs-Host Disease, leukemia | Stem Cell Exhaustion | Minor histocompatibility antigens (mHA) mediate much of the graft vs. leukemia (GvL) effect and graft vs. host disease (GvHD) in patients who undergo allogeneic stem cell transplantation (SCT). | 21858034 |
| Heart failure | Stem Cell Exhaustion | Two of these splicing factors, RBM25 and LUC7L3, were elevated in human heart failure tissue and mediated truncation of SCN5A mRNA in both Jurkat cells and human embryonic stem cell-derived cardiomyocytes. | 21859973 |
| Neoplasms | Stem Cell Exhaustion | Immunophenotype of tumor cells with intermediate morphology suggested a progenitor cell origin for this tumor. | 21860552 |
| Lymphohistiocytosis, Hemophagocytic | Stem Cell Exhaustion | Hematopoietic stem cell transplantation with reduced intensity conditioning from a family haploidentical donor in an infant with familial hemophagocytic lymphohistocytosis. | 21863286 |
| Familial Hemophagocytic Lymphocytosis, Lymphohistiocytosis, Hemophagocytic | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation is the only curative method for patients with familial hemophagocytic lymphohistiocytosis (FHL). | 21863286 |
| Lymphoma, Follicular | Stem Cell Exhaustion | The impact of high-dose chemotherapy, autologous stem cell transplant and conventional chemotherapy on quality of life of long-term survivors with follicular lymphoma. | 21864036 |
| Lymphoma, Follicular | Stem Cell Exhaustion | In this study we investigated the quality of life (QoL) of long-term survivors with follicular lymphoma (FL) after high-dose chemotherapy (HDCT) and autologous stem cell transplant (ASCT) using two standardized questionnaires. | 21864036 |
| diabetic | Stem Cell Exhaustion | Alterations of epithelial stem cell marker patterns in human diabetic corneas and effects of c-met gene therapy. | 21866211 |
| diabetic | Stem Cell Exhaustion | The present study examined whether limbal stem cell marker patterns were altered in diabetic corneas and whether c-met gene overexpression could normalize these patterns. | 21866211 |
| diabetic | Stem Cell Exhaustion | Cryostat sections of 28 ex vivo and 26 organ-cultured autopsy human normal and diabetic corneas were examined by immunohistochemistry using antibodies to putative limbal stem cell markers including ATP-binding cassette sub-family G member 2 (ABCG2), N-cadherin, DNp63a, tenascin-C, laminin g3 chain, keratins (K) K15, K17, K19, b(1) integrin, vimentin, frizzled 7, and fibronectin. | 21866211 |
| Diabetes | Stem Cell Exhaustion | The data suggest that limbal stem cell compartment is altered in long-term diabetes. | 21866211 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Studies of haploidentical hematopoietic stem cell transplantation (HSCT) have identified threshold doses of T cells below which severe GVHD is usually absent. | 21868572 |
| Erectile dysfunction | Stem Cell Exhaustion | Arterial erectile dysfunction: reliability of penile Doppler evaluation integrated with serum concentrations of late endothelial progenitor cells and endothelial microparticles. | 21868743 |
| Hypogonadism, Metabolic Syndrome X, Erectile dysfunction | Stem Cell Exhaustion | We recently showed the diagnostic value of a new immunophenotype of blood endothelial progenitor cells (EPC) (CD45(-)/CD34(+)/CD144(+)) and endothelial microparticles (EMP) (CD45(-)/CD144(+)/annexin V(+)) in patients with arterial erectile dysfunction (AED), particularly in patients with associated late-onset hypogonadism and/or metabolic syndrome. | 21868743 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | Dynamics of cytomegalovirus (CMV) plasma DNAemia in initial and recurrent episodes of active CMV infection in the allogeneic stem cell transplantation setting: implications for designing preemptive antiviral therapy strategies. | 21871245 |
| Communicable Diseases | Stem Cell Exhaustion | Preemptive antiviral therapy strategies for active cytomegalovirus (CMV) infection occurring in allogeneic stem cell transplant recipients should be optimized to avoid overtreatment. | 21871245 |
| Hodgkin Disease, LIPC gene | Stem Cell Exhaustion | Late relapses following high-dose autologous stem cell transplantation (HD-ASCT) for Hodgkin's lymphoma (HL) in the ABVD therapeutic era. | 21871246 |
| Hodgkin Disease, LIPC gene | Stem Cell Exhaustion | Salvage chemotherapy followed by high-dose autologous stem cell transplantation (HD-ASCT) is the standard of care for patients who have relapsed or refractory Hodgkin's lymphoma (HL). | 21871246 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Significant oral graft-versus-host disease after allogeneic stem cell transplantation with the FLU/MEL conditioning regimen. | 21873943 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Oral graft-versus-host disease (GVHD) is a significant complication after allogeneic stem cell transplantation (SCT) and there is no consistent information about its characteristics in patients after reduced-intensity conditioning regimen FLU/MEL (fludarabine 120 mg/m2 and melphalan 140 mg/m2). | 21873943 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Intravenous compared with oral busulfan as preparation for allogeneic hematopoietic progenitor cell transplantation for AML and MDS. | 21874055 |
| Specialty Type - cancer | Stem Cell Exhaustion | A generalized avoidant coping style before treatment increased interference from common cancer symptoms six months after hematopoietic stem cell transplantation. | 21875845 |
| Hematologic Neoplasms, Zygomycosis, Aspects of mortality statistics | Stem Cell Exhaustion | Mortality in hematologic malignancy and hematopoietic stem cell transplant patients with mucormycosis, 2001 to 2009. | 21876046 |
| Zygomycosis, Malignant Neoplasms | Stem Cell Exhaustion | We assessed clinical characteristics and mortality among stem cell transplant and hematologic malignancy patients diagnosed with mucormycosis from 2001 to 2009. | 21876046 |
| Aggressive course | Stem Cell Exhaustion | However, some cells appear to escape and generate stable colonies with an aggressive tumor stem cell-like phenotype. | 21878644 |
| Drug Eruptions | Stem Cell Exhaustion | Further studies provided evidence for the stabilization of Nrf2 due to reduced 26 S proteasome activity and increased p21 association as the driving signaling event that contributes to the transition from a high ROS quiescent state to a low ROS proliferating stage in drug-induced tumor stem cell enrichment. | 21878644 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | A subset of cancer cells, termed cancer stem cells, can elude conventional treatments and eventually regenerate a tumor that is more aggressive. | 21878644 |
| Syndrome | Stem Cell Exhaustion | Cord colitis syndrome in cord-blood stem-cell transplantation. | 21879899 |
| Diarrhea | Stem Cell Exhaustion | Diarrhea is a frequent complication of hematopoietic stem-cell transplantation (HSCT). | 21879899 |
| Diarrhea | Stem Cell Exhaustion | After the transplantation and engraftment of hematopoietic stem cells from umbilical-cord blood, we observed a new syndrome of culture-negative, antibiotic-responsive diarrhea not attributable to any known cause. | 21879899 |
| Intraoperative floppy iris syndrome, Yeast infection | Stem Cell Exhaustion | Antifungal prophylaxis for allogeneic haematopoietic stem-cell transplant (alloHCT) recipients should prevent invasive mould and yeast infections (IFIs) and be well tolerated. | 21880032 |
| Virus Diseases | Stem Cell Exhaustion | Etiologies include myelotoxic agents, viral infections, and possibly transplant-related factors such as the intensity of the conditioning regimen and the source of stem cells. | 21880629 |
| Cytopenia | Stem Cell Exhaustion | Peripheral blood stem cells did not confer protection from cytopenias when compared to bone marrow. | 21880629 |
| Secondary malignant neoplasm of bone, Specialty Type - cancer, Primary malignant neoplasm | Stem Cell Exhaustion | Increased expression of putative cancer stem cell markers in primary prostate cancer is associated with progression of bone metastases. | 21882211 |
| Aggressive behavior, Prostate carcinoma | Stem Cell Exhaustion | A number of putative stem cell markers have been associated with aggressiveness of prostate cancer, including alpha 2 and alpha 6 integrin and c-met. | 21882211 |
| Prostate carcinoma, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | The study aimed to test the hypothesis that the development of bone metastasis correlates with the proportion of prostate cancer stem cell-like cells present in the primary tumor. | 21882211 |
| Prostate carcinoma | Stem Cell Exhaustion | It can be concluded that percentage of stem cell-like prostate cancer cells has a prognostic impact especially on the risk of metastatic bone progression. | 21882211 |
| Febrile Neutropenia | Stem Cell Exhaustion | We evaluated inflammatory markers in febrile neutropenic lymphoma patients undergoing high-dose chemotherapy with autologous stem cell support. | 21883353 |
| Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Cytoreductive treatment with clofarabine/ara-C combined with reduced-intensity conditioning and allogeneic stem cell transplantation in patients with high-risk, relapsed, or refractory acute myeloid leukemia and advanced myelodysplastic syndrome. | 21883483 |
| Toxic effect, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Purpose of this retrospective analysis was to evaluate the antileukemic efficacy and toxicity of clofarabine-based chemotherapy followed by RIC and allogeneic stem cell transplantation (SCT) for high-risk, relapsed, or refractory acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). | 21883483 |
| glycation | Stem Cell Exhaustion | Serum levels of advanced glycation end products (AGEs) are inversely associated with the number and migratory activity of circulating endothelial progenitor cells in apparently healthy subjects. | 21884000 |
| Cardiovascular Diseases, Cyclophosphamide/Vincristine/Dacarbazine Regimen | Stem Cell Exhaustion | Endothelial progenitor cells (EPCs) have been shown to participate in the process of vascular repair, thus playing a protective role against cardiovascular disease (CVD). | 21884000 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | This study evaluated azacitidine as treatment of minimal residual disease (MRD) determined by a sensitive donor chimerism analysis of CD34(+) blood cells to pre-empt relapse in patients with CD34(+) myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (HSCT). | 21886171 |
| Thalassemia | Stem Cell Exhaustion | Stem-cell transplantation is the preferred treatment for the severe forms of thalassemia. | 21886666 |
| Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Sclerodermatous chronic graft-versus-host disease (cGVHD) following allogeneic hematopoietic stem cell transplantation (HSCT) in children is difficult to treat and life-threatening. | 21890415 |
| Specialty Type - cancer | Stem Cell Exhaustion | Zinc finger E-box-binding (ZEB) proteins ZEB1 and ZEB2 are transcription factors essential in TGF-b-mediated senescence, epithelial-to-mesenchymal transition (EMT), and cancer stem cell functions. | 21890822 |
| Liver carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Prediction of posthepatectomy recurrence of hepatocellular carcinoma by circulating cancer stem cells: a prospective study. | 21892074 |
| Liver carcinoma, Specialty Type - cancer, Hollings Cancer Center | Stem Cell Exhaustion | To investigate whether circulating cancer stem cells (CSCs) of hepatocellular carcinoma (HCC) can predict its recurrence after hepatectomy. | 21892074 |
| Multiple Myeloma | Stem Cell Exhaustion | [Optimization of mobilization regimes of blood hemopoietic stem cells in patients with multiple myeloma]. | 21894752 |
| Trauma, Nervous System | Stem Cell Exhaustion | Interest in promoting regeneration of the injured nervous system has recently turned toward the use of endogenous stem cells. | 21895532 |
| Traumatic | Stem Cell Exhaustion | Endogenous GFAP-positive neural stem/progenitor cells in the postnatal mouse cortex are activated following traumatic brain injury. | 21895532 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Methotrexate dose delivery is more important than ciclosporin level in graft-versus-host disease prophylaxis following T-replete reduced-intensity sibling allogeneic stem cell transplant. | 21898174 |
| Chronic graft-versus-host disease | Stem Cell Exhaustion | We investigated the contributions of methotrexate (MTX) and ciclosporin (CsA) prophylaxis to acute/chronic graft-versus-host disease (a/cGvHD) prevention following reduced-intensity conditioned allogeneic haematopoietic stem cell transplant (HSCT). | 21898174 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Emerging evidence suggests that tumors contain and are driven by a cellular component that displays stem cell properties, the so-called cancer stem cells (CSCs). | 21898409 |
| Specialty Type - cancer, Primary Neoplasm | Stem Cell Exhaustion | CD133 and CD44 cell surface markers do not identify cancer stem cells in primary human gastric tumors. | 21898409 |
| Prostatic Neoplasms | Stem Cell Exhaustion | The location of stem cells in the epithelium of the prostatic acinus remains uncertain, as does the cellular origin of prostatic neoplasia. | 21898875 |
| Disease, Neurodegenerative Disorders | Stem Cell Exhaustion | Induced pluripotent stem cell (iPSC) technology can be used to model human disorders and provide novel opportunities to study cellular mechanisms and establish therapeutic strategies against various diseases, including neurodegenerative diseases. | 21900357 |
| Alzheimers Disease | Stem Cell Exhaustion | Modeling familial Alzheimer's disease with induced pluripotent stem cells. | 21900357 |
| Liver Failure | Stem Cell Exhaustion | This study demonstrated the safety and short-term efficacy of autologous bone marrow-derived mesenchymal stem cell injection in liver cell failure. | 21900788 |
| Uveal melanoma | Stem Cell Exhaustion | Expression of CD133 and other putative stem cell markers in uveal melanoma. | 21900792 |
| Cutaneous Melanoma, Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | 'Cancer stem cells' (CSCs) are tumor cells with stem cell properties hypothesized to be responsible for tumorigenesis, metastatis, and resistance to treatment, and have been identified in different tumors including cutaneous melanoma, using stem cell markers such as CD133. | 21900792 |
| Uveal melanoma | Stem Cell Exhaustion | This study explored expression of CD133 and other putative stem cell markers in uveal melanoma. | 21900792 |
| Uveal melanoma | Stem Cell Exhaustion | Eight uveal melanoma cell lines were subjected to flow-cytometric (fluorescence-activated cell sorting) analysis of CD133 and other stem cell markers. | 21900792 |
| Uveal melanoma | Stem Cell Exhaustion | Ocular, uveal melanoma, and hematopoietic stem cell distributions of C-terminal and N-terminal CD133 mRNA splice variants were compared by reverse-transcription PCR. | 21900792 |
| Uveal melanoma | Stem Cell Exhaustion | Further experiments are needed to isolate stem cell marker-positive cells, to evaluate their functional properties and to explore therapeutical approaches to these putative CSCs in uveal melanoma. | 21900792 |
| Fibromatosis | Stem Cell Exhaustion | Recapitulation of fibromatosis nodule by multipotential stem cells in immunodeficient mice. | 21901157 |
| Fibromatosis | Stem Cell Exhaustion | In this study, we demonstrate that fibromatosis stem cells (FSCs) can be isolated from palmar nodules but not from cord or normal palm tissues. | 21901157 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Although BCR-ABL+ stem cells in chronic myeloid leukemia (CML) resist elimination by targeted pharmacotherapy in most patients, immunological graft-versus-leukemia effects can cure the disease. | 21904381 |
| Lupus Erythematosus, Systemic, physiopathological | Stem Cell Exhaustion | Reversal of serologic, immunologic, and histologic dysfunction in mice with systemic lupus erythematosus by long-term serial adipose tissue-derived mesenchymal stem cell transplantation. | 21904997 |
| Lupus Erythematosus, Encephalitis, St. Louis | Stem Cell Exhaustion | To investigate the efficacy of human adipose tissue-derived mesenchymal stem cell (AD-MSC) transplantation in systemic lupus erythematosus (SLE) and to determine the optimal transplantation window for stem cells either before or after disease onset. | 21904997 |
| Multiple Myeloma | Stem Cell Exhaustion | Effects of peripheral blood stem cell apheresis on systemic cytokine levels in patients with multiple myeloma. | 21905955 |
| Multiple Myeloma | Stem Cell Exhaustion | We investigated how peripheral blood stem cell (PBSC) collection affected plasma angioregulatory cytokine levels in 15 consecutive myeloma patients. | 21905955 |
| Hypertension, CTCAE | Stem Cell Exhaustion | Effects of calcium channel blockers on glucose tolerance, inflammatory state, and circulating progenitor cells in non-diabetic patients with essential hypertension: a comparative study between azelnidipine and amlodipine on glucose tolerance and endothelial function--a crossover trial (AGENT). | 21906391 |
| Hypertension, CTCAE | Stem Cell Exhaustion | These results suggest that azelnidipine treatment may have beneficial effects on glucose tolerance, insulin sensitivity, the inflammatory state, and number of circulating progenitor cells in non-diabetic patients with essential hypertension. | 21906391 |
| Neoplasms | Stem Cell Exhaustion | Recent findings on the regulation of stem cell (SC) division and reprogramming suggest the intriguing possibility that p53 also carries out its tumor suppression function by regulating SC homeostasis. | 21907001 |
| Pulmonary Complication | Stem Cell Exhaustion | Lethal pulmonary complications after pediatric allogeneic hematopoietic stem cell transplantation. | 21909046 |
| Pulmonary Complication | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (HSCT) in children is accompanied by a transplant-related mortality of 10% to 30%, which is the result of lethal pulmonary complications (LPCs) in many cases. | 21909046 |
| Chronic Kidney Disease, CTCAE | Stem Cell Exhaustion | Endostatin and vascular endothelial growth factor: potential regulators of endothelial progenitor cell number in chronic kidney disease. | 21909059 |
| Specialty Type - cancer | Stem Cell Exhaustion | Stem cells and cancer cells accumulate MB(d)s by evading autophagosome encapsulation and exhibit low autophagic activity. | 21909099 |
| Specialty Type - cancer | Stem Cell Exhaustion | MB(d) enrichment enhances reprogramming to induced pluripotent stem cells and increases the in vitro tumorigenicity of cancer cells. | 21909099 |
| Post-Treatment Lyme Disease Syndrome, Post-transplant lymphoproliferative disorder | Stem Cell Exhaustion | Posttransplant lymphoproliferative disorders (PTLDs) are among the most serious and potentially fatal complications of both stem-cell and solid-organ transplantation. | 21911168 |
| Cessation of life, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | In this high risk AML population, HiDAC/MITO induction demonstrated an overall response rate of 55% with a low induction death rate of 9% and allowed 32 (41%) patients to proceed to allogeneic stem cell transplant. | 21913806 |
| Multiple Myeloma | Stem Cell Exhaustion | An overview of the VISTA trial: newly diagnosed, untreated patients with multiple myeloma ineligible for stem cell transplantation. | 21913826 |
| Multiple Myeloma | Stem Cell Exhaustion | The VISTA study evaluated the effect of this combination with or without the first-in-class proteasome inhibitor bortezomib in newly diagnosed myeloma patients who were not candidates for autologous stem cell transplantation. | 21913826 |
| melphalan/prednisone protocol, Multiple Myeloma | Stem Cell Exhaustion | These results confirm the superiority of MP plus bortezomib combination over MP therapy in treatment-naive patients with newly diagnosed multiple myeloma who are ineligible for autologous stem cell transplantation. | 21913826 |
| Syringocystadenoma Papilliferum | Stem Cell Exhaustion | We focused on one cell type, undifferentiated clear cells, which have been suggested to be pluripotent cells bearing stem cell nature in syringocystadenoma papilliferum. | 21914158 |
| Neoplasms | Stem Cell Exhaustion | Immunohistochemically, the tumor cells were negative for cytokeratin 15, which is known as a relatively specific marker for multipotent stem cells in the follicular bulge. | 21914158 |
| Specialty Type - cancer, Glioblastoma | Stem Cell Exhaustion | Identification of cancer stem cells from human glioblastomas: growth and differentiation capabilities and CD133/prominin-1 expression. | 21916848 |
| Specialty Type - cancer, Glioblastoma | Stem Cell Exhaustion | CD133 can be a marker of tumorigenic CSCs (cancer stem cells) in human GBM (glioblastoma multiforme), although tumorigenic CD133-negative CSCs have been also isolated. | 21916848 |
| Common (qualifier value), Malignant tumor of colon | Stem Cell Exhaustion | Common cancer stem cell gene variants predict colon cancer recurrence. | 21918173 |
| Malignant tumor of colon, Specialty Type - cancer | Stem Cell Exhaustion | Recent evidence suggests that cancer stem cells (CSC) are responsible for key elements of colon cancer progression and recurrence. | 21918173 |
| MS gene | Stem Cell Exhaustion | To assess safety and tolerability of treatment with autologic multipotent mesenchymal stem cells (MSC) in multiple sclerosis (MS), we have obtained autologic red bone marrow-derived MSC from 8 patients. | 21919233 |
| Multiple Myeloma | Stem Cell Exhaustion | Non-cryopreserved hematopoietic stem cell transplantation in multiple myeloma, a single center experience. | 21919958 |
| Multiple Myeloma | Stem Cell Exhaustion | Several clinical trials have shown the superiority of high-dose therapy (HDT) and autologous stem cell transplantation (ASCT) over conventional dose therapy for patients with multiple myeloma. | 21919958 |
| Hepatitis B | Stem Cell Exhaustion | New therapeutic options like monoclonal antibodies (anti-CD20/rituximab) and hematopoietic stem cell transplantation (HSCT) have increased both the effectiveness of therapies and the risk for reactivation of Hepatitis B virus (HBV). | 21920838 |
| Pancreatic Ductal Adenocarcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Comparative evaluation of cancer stem cell markers in normal pancreas and pancreatic ductal adenocarcinoma. | 21922151 |
| Pancreatic Ductal Adenocarcinoma, Specialty Type - cancer, Neoplasms, Resistance Process, ANOPHTHALMIA AND PULMONARY HYPOPLASIA | Stem Cell Exhaustion | Chemoresistance and self-renewal of cancer stem cells (CSC), found in many tumors including pancreatic ductal adenocarcinoma (PDAC), are believed to underlie tumor mass regrowth. | 21922151 |
| Multiple Myeloma | Stem Cell Exhaustion | Comparison of fixed dose pegfilgrastim and daily filgrastim after autologous stem cell transplantation in patients with multiple myeloma autografted on a outpatient basis. | 21922508 |
| Chemotherapy-Induced Febrile Neutropenia | Stem Cell Exhaustion | Peg-filgrastim (PEG), a long-acting recombinant G-CSF, has similar efficacy when compared to conventional G-CSF for chemotherapy-induced neutropenia, but little is known about its use in the autologous stem-cell transplantation (ASCT) setting, namely in patients programmed to be autografted on outpatient basis. | 21922508 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Multiple extramedullary relapses without bone marrow involvement after second allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia. | 21923886 |
| Acute leukemia | Stem Cell Exhaustion | Our experience demonstrates that infusing a megadose of extensively T-cell-depleted hematopoietic peripheral blood stem cells after an immuno-myeloablative conditioning regimen in acute leukemia patients ensures sustained engraftment with minimal GvHD without the need of any post-transplant immunosuppressive treatment. | 21925085 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Hematopoietic stem cell transplantation provides the only potential curative option in many patients with hematological malignancies. | 21925089 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Nonmyeloablative haploidentical stem cell transplantation with post-transplantation cyclophosphamide seems to be a promising, potentially curative, option for patients with hematological malignancies who either lack an HLA-matched related or unrelated donor, or in whom a myeloablative preparative regimen is contraindicated due to significant co-morbidities or history of extensive pre-treatment. | 21925089 |
| leukemia | Stem Cell Exhaustion | Allogeneic stem cell transplantation for patients harboring T315I BCR-ABL mutated leukemias. | 21926354 |
| Graft-vs-Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Chronic graft-versus-host disease (GVHD) remains a serious complication after allogeneic hematopoietic stem cell transplantation (HCT). | 21926960 |
| Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | Endothelial progenitor cells are associated with response to chemotherapy in human non-small-cell lung cancer. | 21927909 |
| Neoplasms | Stem Cell Exhaustion | Bone marrow-derived endothelial progenitor cells (EPCs) play an important role in angiogenesis and tumor growth. | 21927909 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | High-dose thiotepa, etoposide and carboplatin as conditioning regimen for autologous stem cell transplantation in patients with high-risk non-Hodgkin lymphoma. | 21928053 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | High-dose chemotherapy conditioning regimens followed by autologous stem cell transplantation generally provide good results in non-Hodgkin lymphoma. | 21928053 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | The thiotepa, etoposide and carboplatin conditioning regimen for autologous stem cell transplantation in non-Hodgkin lymphoma has a good anti-lymphoma effect and provides encouraging results in terms of response to treatment and 5-year overall survival. | 21928053 |
| Specialty Type - cancer | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (HSCT) is an intensive cancer therapy entailing numerous physical, emotional, cognitive, and practical challenges. | 21928059 |
| Prostate carcinoma, Specialty Type - cancer, Hormone refractory prostate cancer | Stem Cell Exhaustion | A stem cell model of prostate cancer tumourigenesis explains progression to castration resistant prostate cancer (CRPC) and offers novel perspectives in targeting this cancer in its more advanced forms. | 21929909 |
| Neoplasms | Stem Cell Exhaustion | Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14. | 21930782 |
| Neoplasms | Stem Cell Exhaustion | Overall, these studies identify GATA-3 as an important regulator of tumor initiation through its ability to promote the differentiation of committed luminal progenitor cells. | 21930782 |
| Colorectal Carcinoma | Stem Cell Exhaustion | Circulation of progenitor cells in obese and lean colorectal cancer patients. | 21930958 |
| Cytogenetic Complete Response | Stem Cell Exhaustion | The purpose of this study was to measure the frequency of circulating CD34-positive endothelial and progenitor cells in the circulation and evaluate their potential values as CRC biomarkers. | 21930958 |
| Hematological Disease, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Myelodysplastic syndromes (MDSs) are clonal disorders of hematopoietic stem cells (HSCs) characterized by ineffective hematopoiesis. | 21933023 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Acute myeloid leukemias arise from a rare population of leukemic cells, known as leukemic stem cells, which initiate the disease and contribute to frequent relapses. | 21933861 |
| Tumor necrosis | Stem Cell Exhaustion | This study examined the effects of cytokines interleukin-1b, tumor necrosis factor-a and interferon-g on apoptosis of b-thal/HbE erythroid progenitor cells in vitro, including nitric oxide-mediated apoptotic processes. | 21934298 |
| Thalassemia | Stem Cell Exhaustion | The marked sensitivity of erythroid progenitor cells from b-thal/HbE patients to cytokine-induced apoptosis via an NO-mediated process reflects a proapoptotic status of such thalassemic red blood cells. | 21934298 |
| Fatty Liver Disease | Stem Cell Exhaustion | Ultrastructural examinations of the liver progenitor/oval cells in children with NASH show a quite prominent number of these cells, especially their two types, hepatic progenitor cells (HPCs) and intermediate hepatocyte-like cells (IHCs), with intermediate bile-like cells being the least frequent. | 21940261 |
| Adenomatous Polyposis Coli, Peutz-Jeghers Syndrome | Stem Cell Exhaustion | Aberrant intestinal stem cell lineage dynamics in Peutz-Jeghers syndrome and familial adenomatous polyposis consistent with protracted clonal evolution in the crypt. | 21940722 |
| Burn injury | Stem Cell Exhaustion | Their resemblance to ASCs could also be cause for speculation that in deep burns the subcutaneous adipose tissue might be an important stem cell source for the healing wound. | 21944933 |
| Burn, CTCAE | Stem Cell Exhaustion | A population of multipotent stem cells in burn eschar could be an interesting resource for tissue engineering approaches to heal burn wounds. | 21944933 |
| Burn, CTCAE, Burn injury | Stem Cell Exhaustion | The origin of the cells from burn eschar remains unclear, but it is likely they represent a population of adult stem cells mobilized from other parts of the body in response to the burn injury. | 21944933 |
| Huntingtons Disease Pathway | Stem Cell Exhaustion | No change in progenitor cell proliferation in the hippocampus in Huntington's disease. | 21946006 |
| Neutropenia, Hematologic Neoplasms, Pregnancy Complications, Infectious | Stem Cell Exhaustion | 18F-FDG PET/CT for diagnosing infectious complications in patients with severe neutropenia after intensive chemotherapy for haematological malignancy or stem cell transplantation. | 21947022 |
| Neutropenia, Hematologic Neoplasms | Stem Cell Exhaustion | Twenty-eight consecutive patients with neutropenia as a result of intensive chemotherapy for haematological malignancies or myeloablative therapy for haematopoietic stem cell transplantation were prospectively included. | 21947022 |
| Aggressive Non-Hodgkin Lymphoma | Stem Cell Exhaustion | To evaluate the prognostic value of the cell of origin (COO) in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBLC), prospectively treated by rituximab, dexamethasone, high-dose cytarabine, and cisplatin (R-DHAP) versus rituximab, ifosfamide, carboplatin, and etoposide and followed by intensive therapy plus autologous stem-cell transplantation on the Collaborative Trial in Relapsed Aggressive Lymphoma (CORAL) trial. | 21947824 |
| Adult Glioblastoma | Stem Cell Exhaustion | Mast cell accumulation in glioblastoma with a potential role for stem cell factor and chemokine CXCL12. | 21949886 |
| Inflammation, Psoriasis vulgaris | Stem Cell Exhaustion | In the skin, vitamin D receptor (VDR) is a master regulator of epidermal barrier function, inflammation, stem cell proliferation and microbial defense; therefore, we tested whether VDR 3'-regulatory haplotypes, a portion of which affect VDR transcriptional efficiency, allelic symmetry and mRNA turnover, were associated with psoriasis vulgaris. | 21951018 |
| Ischemic, Vascular System Injuries | Stem Cell Exhaustion | Platelet stromal-cell-derived factor-1 (SDF-1) plays a pivotal role in angiogenesis and the regeneration of ischaemic tissue through the regulation of haematopoietic progenitor cells and is upregulated at the sites of vascular injury and platelet activation. | 21951424 |
| Ischemia | Stem Cell Exhaustion | Autologous bone marrow-derived stem cells have been ascribed an important therapeutic role in No-Option Critical limb Ischemia (NO-CLI). | 21951607 |
| Carcinoma, Neoplastic Stem Cells | Stem Cell Exhaustion | Mixed adenoneuroendocrine carcinoma (MANEC) of the gallbladder: a possible stem cell tumor? | 21951672 |
| Neoplasms, Genotype | Stem Cell Exhaustion | The aforementioned histological, ultrastructural and immunohistochemical profile is strongly suggestive of a biphenotypic stem/progenitor cell tumor of the gallbladder. | 21951672 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Acute myeloid leukemia of donor origin after allogeneic stem cell transplantation from a sibling who harbors germline XPD and XRCC3 homozygous polymorphisms. | 21951951 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Additionally, polymorphisms of the XPA, XPD, XRCC1, XRCC3 and RAD51 DNA repair genes revealed three unfavorable alleles with low DNA repair capacity.In summary, we report the first case of AML involving XPD and XRCC3 polymorphisms from donor origin following allogeneic stem cell transplantation and highlight the potential need for careful analysis of DNA repair gene polymorphisms in selecting candidate donors prior to allogeneic stem cell transplantation. | 21951951 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Generation of human induced pluripotent stem cells from osteoarthritis patient-derived synovial cells. | 21953087 |
| Degenerative polyarthritis | Stem Cell Exhaustion | This study was undertaken to generate and characterize human induced pluripotent stem cells (PSCs) from patients with osteoarthritis (OA) and to examine whether these cells can be developed into disease-relevant cell types for use in disease modeling and drug discovery. | 21953087 |
| leukemia, MLL/MLLT1 Fusion Gene | Stem Cell Exhaustion | The observed inconsistency between the clinical cure and the presence of detectable MLL/ENL transcript suggests the existence of a MLL/ENL-expressing "preleukemia" stem cells, similar to what demonstrated for the AML1/ETO-positive leukemia setting. | 21953510 |
| Respiratory Tract Infections | Stem Cell Exhaustion | Influenza viruses cause potentially fatal respiratory infections in stem cell transplant patients. | 21954837 |
| Cessation of life | Stem Cell Exhaustion | We propose that reconstructing host immunity through adoptive transfer of influenza virus-specific T cells will reduce the frequency of influenza-related deaths in the period of severe immune suppression that follows stem cell transplantation. | 21954837 |
| Amyotrophic Lateral Sclerosis, Antilymphocyte Serum | Stem Cell Exhaustion | Mesenchymal stem cells/marrow stromal cells (MSC) represent a promising tool for stem cell-based clinical trials in amyotrophic lateral sclerosis (ALS). | 21954839 |
| Subcutaneous panniculitis-like T-cell lymphoma | Stem Cell Exhaustion | Durable remission in a patient with refractory subcutaneous panniculitis-like T-cell lymphoma relapse after allogeneic hematopoietic stem cell transplantation through withdrawal of cyclosporine. | 21959522 |
| Multiple Myeloma | Stem Cell Exhaustion | Autologous stem cell transplantation is an important part of therapy in patients with multiple myeloma. | 21959988 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Prognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks. | 21960591 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Genes targeted by Polycomb group (PcG) proteins and genes associated with bivalent histone marks in stem cells showed increased aberrant methylation in AML (P < .0001). | 21960591 |
| Multiple Myeloma | Stem Cell Exhaustion | Autologous haemopoietic stem-cell transplantation followed by allogeneic or autologous haemopoietic stem-cell transplantation in patients with multiple myeloma (BMT CTN 0102): a phase 3 biological assignment trial. | 21962393 |
| Multiple Myeloma | Stem Cell Exhaustion | Autologous haemopoietic stem-cell transplantation (HSCT) improves survival in patients with multiple myeloma, but disease progression remains an issue. | 21962393 |
| Electrocardiogram: myocardial infarction (finding), Coronary heart disease | Stem Cell Exhaustion | [Coronary disease extension determines mobilization of endothelial progenitor cells and cytokines after a first myocardial infarction with ST elevation]. | 21962766 |
| Coronary heart disease | Stem Cell Exhaustion | The aim of this study was to determine the time sequence of various sets of endothelial progenitor cells and angiogenic cytokines (vascular endothelial growth factor, hepatocyte growth factor) according to the degree of extension of the postinfarction coronary disease. | 21962766 |
| One Vessel Coronary Disease, Acute myocardial infarction | Stem Cell Exhaustion | Although the release kinetics of different subsets of endothelial progenitor cells in patients with a first acute myocardial infarction with ST elevation was similar in those with single vessel disease to those with multivessel disease, the number of circulating endothelial progenitor cells was greater in the patients with single vessel disease. | 21962766 |
| Secondary Acute Myeloid Leukemia, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Upfront allogeneic blood stem cell transplantation for patients with high-risk myelodysplastic syndrome or secondary acute myeloid leukemia using a FLAMSA-based high-dose sequential conditioning regimen. | 21963618 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | The purpose of our prospective single-center study was to examine the safety and efficacy of an allogeneic hematopoietic stem cell transplantation (HSCT) following a sequential conditioning regimen as first-line therapy for previously untreated patients with high-risk MDS or sAML. | 21963618 |
| Acute lymphocytic leukemia, Myeloid Leukemia, Chronic, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | We evaluated the ability of an MM ranking system, HistoCheck, to predict the risk associated with HLA class I disparity in a population of 744 single allele or antigen HLA-A, -B, or -C MM myeloablative unrelated donor hematopoietic stem cell transplantation recipients with acute myelogenous leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia, or myelodysplastic syndrome, facilitated through the National Marrow Donor Program between 1988 and 2003. | 21963622 |
| Infection | Stem Cell Exhaustion | Diagnostic value of serum procalcitonin and C-reactive protein for infections after allogeneic hematopoietic stem cell transplantation versus nontransplant setting. | 21963733 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | The purpose of this study was to evaluate its diagnostic value after hematopoietic stem cell transplantation (HSCT), where non-infectious febrile complications such as graft-versus-host disease frequently develop. | 21963733 |
| Septicemia, Necrosis, Disseminated Intravascular Coagulation | Stem Cell Exhaustion | On day 5 after stem cell transplantation, progressive local tissue necrosis led to septicemia and disseminated intravascular coagulation. | 21963743 |
| Ischemia | Stem Cell Exhaustion | Vasoprotective effects of erythropoietin in animal models are mediated by endothelium-derived NO and/or mobilization of EPCs (endothelial progenitor cells) and may be enhanced by ischaemia: whether they are present in humans is unknown. | 21966999 |
| PAFAH1B1 wt Allele, Erythropoietin | Stem Cell Exhaustion | Notch signaling has been linked to impaired erythropoietic and megakaryopoietic development of CD34+ progenitor cells, but its role in MDS is unclear. | 21967505 |
| Neoplasms | Stem Cell Exhaustion | The immunohistochemical expression of the putative brain tumor stem cell markers CD133 and Nestin in paraffin sections was analyzed using morphometry. | 21971709 |
| Post-Traumatic Stress Disorder | Stem Cell Exhaustion | Posttraumatic growth, social support, and social constraint in hematopoietic stem cell transplant survivors. | 21972000 |
| Neurodegenerative Disorders, Minor Axis Cross-sectional Diameter, Motor Neuron Disease | Stem Cell Exhaustion | The lack of effective drug therapies for motor neuron diseases (MND), and in general for all the neurodegenerative disorders, has increased the interest toward the potential use of stem cells. | 21978082 |
| Cancer Pain, Non-Metastatic Childhood Soft Tissue Sarcoma | Stem Cell Exhaustion | A novel splice variant of the stem cell marker LGR5/GPR49 is correlated with the risk of tumor-related death in soft-tissue sarcoma patients. | 21978106 |
| Pneumonia, Interstitial | Stem Cell Exhaustion | Interstitial pneumonia after autologous hematopoietic stem cell transplantation in B-cell non-hodgkin lymphoma. | 21978956 |
| Teratoma | Stem Cell Exhaustion | Our results suggest that the origin of this uterine teratoma is most likely pluripotential stem cell of uterus or primordial germ cell before meiosis I. | 21979590 |
| Kidney Failure, Acute | Stem Cell Exhaustion | Several combined immunosuppression therapies failed to resolve recurrent acute renal failure; autologous peripheral blood stem cell transplantation was therefore applied. | 21979795 |
| Neoplasms | Stem Cell Exhaustion | This offers an improved understanding of the pathways involved in tumor growth from engrafted pluripotent stem cells, which could facilitate the use of ES and iPS cells in regenerative medicine. | 21981310 |
| Alopecia, senile | Stem Cell Exhaustion | Involvement of the bulge region with decreased expression of hair follicle stem cell markers in senile female cases of alopecia areata. | 21981340 |
| anatomical bulb, senile | Stem Cell Exhaustion | To investigate expression levels of stem cell markers, especially CD200, in two senile female cases of AA with unusual lymphocytic cell infiltrates surrounding both the bulge and the bulbar regions. | 21981340 |
| Malignant tumor of colon, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Human colon cancer harbors a small subfraction of tumor-initiating cells (TICs) that is assumed to be a functionally homogeneous stem-cell-like population driving tumor maintenance and metastasis formation. | 21982235 |
| Renal Cell Carcinoma | Stem Cell Exhaustion | Comprehensive analysis of clinical significance of stem-cell related factors in renal cell cancer. | 21982273 |
| Refractory Cytopenia of Childhood | Stem Cell Exhaustion | The present analysis strongly suggests that altered expression of several stem cell related factors may play different roles in RCC. | 21982273 |
| Delayed onset, Decreased platelet count | Stem Cell Exhaustion | PR-104 given weekly may be a suitable protocol for further clinical evaluation as a short course of treatment with fractionated radiotherapy or haematopoietic stem cell support, as its duration of dosing is restricted by delayed-onset and protracted thrombocytopenia. | 21982454 |
| Lung diseases | Stem Cell Exhaustion | The goal of studying early disease in multiple cell and tissue types has driven interest in the use of induced pluripotent stem cells (iPSCs) to model lung disease. | 21984571 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | Mucositis after reduced intensity conditioning and allogeneic stem cell transplantation. | 21985850 |
| Nephrotic Syndrome | Stem Cell Exhaustion | Early occurrence of nephrotic syndrome associated with cord blood stem cell transplantation. | 21986678 |
| Graft-vs-Host Disease, Nephrotic Syndrome, Nuclear non-senile cataract, Chronic graft-versus-host disease | Stem Cell Exhaustion | Nephrotic syndrome (NS) associated with hematopoietic stem cell transplantation (HSCT) is usually related to chronic graft-versus-host disease (GVHD) and invariably occurs later than 100 days after transplantation. | 21986678 |
| Cerebral Small Vessel Diseases, Dementia, Vascular | Stem Cell Exhaustion | We assayed autopsy tissue from 13 vascular dementia patients with small vessel disease and 12 age-matched subjects without cerebrovascular pathology, undertaking immunohistochemistry in the affected brain area and the subventricular zone with a well-characterized battery of antibodies to detect neural stem cells/progenitors and immature neurones, as well as choline acetyltransferase immunoreactivity. | 21988073 |
| Cerebrovascular accident | Stem Cell Exhaustion | Recent work has highlighted a significant increase of neural stem/progenitor cells after stroke in humans. | 21988073 |
| Cerebrovascular Disorders, Cerebral Small Vessel Diseases | Stem Cell Exhaustion | We showed significant increases ranging from 33% to 92% (P < 0.05) in neural progenitor cells around the areas of microvascular pathology and in the subventricular zone in patients with small vessel disease compared to individuals without cerebrovascular changes, even in patients with severe cerebrovascular disease, as defined by neuropathological assessment. | 21988073 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | * It is anticipated that there is a difference in pharmacokinetics in patients after kidney or liver transplantation compared with patients undergoing stem cell transplantation, because of mucositis and interacting drugs (e.g. | 21988410 |
| Allogeneic Hematopoietic Stem Cell Transplantation | Stem Cell Exhaustion | AIM To develop a population pharmacokinetic model of ciclosporin (CsA) in haematopoietic allogeneic stem cell transplantation to facilitate a limited sampling strategy to determine systemic exposure (area under the curve [AUC]), in order to optimize CsA therapy in this patient population. | 21988410 |
| Neoplasms | Stem Cell Exhaustion | Sox-2 was the most prevalent stem cell marker in PA, and many tumors showed synaptophysin positivity. | 21989351 |
| Osteoarthritis of hip | Stem Cell Exhaustion | To determine whether the marrow conversion index (MCI) in MRI is related to the total number of mononuclear and mesenchymal stem cells (MSCs) in proximal femoral metaphysis of patients with hip osteoarthritis. | 21990160 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | Polycomb repressive complex (PRC) target genes in embryonic stem cells were significantly enriched among EBV(-)/high-methylation genes and commonly methylated gastric cancer genes (P = 2 x 10(-15) and 2 x 10(-34), respectively), but not among EBV(+) tumor-specific methylation genes (P = 0.2), suggesting a different cause for EBV(+)-associated de novo methylation. | 21990320 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Plerixafor and Filgrastim XM02 (Tevagastrim) as a first line peripheral blood stem cell mobilisation strategy in patients with multiple myeloma and lymphoma candidated to autologous bone marrow transplantation. | 21992403 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | CD33 is a well-known stem cell target in acute myeloid leukemia. | 21993666 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | CD33 is expressed abundantly on immature CD34(+)/CD38(-) stem cells and may serve as a stem cell target in chronic myeloid leukemia. | 21993666 |
| gemtuzumab ozogamicin, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | CD34(+)/CD38(-) stem cells in chronic myeloid leukemia express Siglec-3 (CD33) and are responsive to the CD33-targeting drug gemtuzumab/ozogamicin. | 21993666 |
| Chronic leukemia (category) | Stem Cell Exhaustion | So far, however, little is known about expression of CD33 on leukemic stem cells in chronic leukemias. | 21993666 |
| Myeloid Leukemia, Chronic, Myeloid neoplasm | Stem Cell Exhaustion | Chronic myelogenous leukemia (CML) is a neoplasm of myeloid progenitor cells expressing Bcr-Abl fusion protein. | 21993902 |
| Leukemia, Myelocytic, Acute, Lymphoproliferative Disorders | Stem Cell Exhaustion | We evaluated applying less restrictive radiological criteria, when supported by specific microbiological findings, to define IPA in acute myeloid leukaemia (AML), lymphoproliferative diseases (LD) and allogeneic stem cell transplant (allo-SCT) patients. | 21999366 |
| Lymphedema | Stem Cell Exhaustion | Autologous stem cells for the treatment of post-mastectomy lymphedema: a pilot study. | 21999374 |
| Lymphedema | Stem Cell Exhaustion | Our objective was to determine the efficacy of autologous stem cells (ASC) in the treatment of lymphedema secondary to mastectomy and axillary lymphadenectomy in comparison with traditional decongestive treatment with compression sleeves. | 21999374 |
| B-Cell Lymphomas | Stem Cell Exhaustion | High-dose therapy and autologous stem cell transplantation in first relapse for diffuse large B cell lymphoma in the rituximab era: an analysis based on data from the European Blood and Marrow Transplantation Registry. | 22005647 |
| B-Cell Lymphomas | Stem Cell Exhaustion | Autologous stem cell transplantation (ASCT) consolidation remains the treatment of choice for patients with relapsed diffuse large B cell lymphoma. | 22005647 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Patients with hematologic malignancies were conditioned using a rabbit antithymocyte globulin-based reduced-intensity conditioning regimen for allogeneic stem cell transplantation. | 22005648 |
| Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Chronic graft-versus-host disease (cGVHD) remains a major cause of non-relapse morbidity and mortality after allogeneic hematopoietic stem cell transplantation. | 22005783 |
| MYELODYSPLASTIC SYNDROME, Acute leukemia | Stem Cell Exhaustion | We assessed HLA-mismatched locus-specific comparison of the outcomes of 351 single-unit UCB and 1,028 unrelated bone marrow (UBM) adult recipients 16 years old or older at the time of transplantation who received first stem cell transplantation with myeloablative conditioning for acute leukemia or myelodysplastic syndromes. | 22008851 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Early versus delayed autologous stem cell transplantation (SCT) results in comparable overall survival in patients with multiple myeloma (MM) who receive alkylator-based therapies. | 22009602 |
| Specialty Type - cancer, Leukoplakia | Stem Cell Exhaustion | Two stem cell markers, ATP-binding cassette, G2 subfamily (ABCG2) and BMI-1, predict the transformation of oral leukoplakia to cancer: a long-term follow-up study. | 22009787 |
| Head and Neck Neoplasms | Stem Cell Exhaustion | ATP-binding cassette, G2 subfamily (ABCG2) and BMI-1 are stem cell markers that have been found to be associated with head and neck tumorigenesis. | 22009787 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | The aim of this study was to evaluate immunohistochemical approaches for predicting the survival of patients with DLBCL following autologous hematopoietic stem cell transplantation (AHSCT). | 22009820 |
| Acute lymphocytic leukemia, BCR gene | Stem Cell Exhaustion | Acute lymphoblastic leukemia (ALL) in second complete remission is one of the most common indications for allogeneic hematopoietic stem cell transplantation (HSCT) in pediatric patients. | 22010101 |
| Infectious Lung Disorder | Stem Cell Exhaustion | A concomitant pulmonary infection was identified more frequently among non-AL patients (P = .005 vs allogeneic hematopoietic stem cell transplant and P = .048 vs others). | 22010103 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer patients were treated twice with autologous CD34+ hematopoietic stem cell-derived, GM-CSF/IFN-g-differentiated DCs pulsed with autologous tumor lysate and KLH, by 4-week interval. | 22013914 |
| Glioma | Stem Cell Exhaustion | Expression profile of embryonic stem cell-associated genes Oct4, Sox2 and Nanog in human gliomas. | 22014056 |
| Glioma, Specialty Type - cancer, Carcinogenesis | Stem Cell Exhaustion | To investigate whether Oct4, Sox2 and Nanog, three core regulatory factors maintaining pluripotency and self-renewal of embryonic stem cells (ESCs), are coexpressed in human gliomas, and whether their expression might be linked to carcinogenesis and the formation of cancer stem cells (CSCs). | 22014056 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Aldehyde dehydrogenase 1 (ALDH1) has been identified as a reliable marker of breast cancer stem cells, and its clinical significance as a prognostic indicator of breast cancer has been reported by several investigators. | 22014057 |
| Intimal proliferation | Stem Cell Exhaustion | These results indicate that monocyte-derived progenitor cells are associated with cardiac allograft vasculopathy, have the ability to transdifferentiate into smooth muscle cells, and thus may contribute to intimal hyperplasia of coronary arteries in cardiac allograft vasculopathy. | 22014346 |
| Autoimmune Diseases | Stem Cell Exhaustion | Stem cell treatment for patients with autoimmune disease by systemic infusion of culture-expanded autologous adipose tissue derived mesenchymal stem cells. | 22017805 |
| Dermatitis, Atopic, Polymyositis, Rheumatoid Arthritis, MS gene, Autoimmune reaction | Stem Cell Exhaustion | Here we report the outcome of treatments with culture expanded human adipose-derived mesenchymal stem cells (hAdMSCs) of 10 patients with autoimmune associated tissue damage and exhausted therapeutic options, including autoimmune hearing loss, multiple sclerosis, polymyotitis, atopic dermatitis and rheumatoid arthritis. | 22017805 |
| Endothelium | Stem Cell Exhaustion | Endothelial progenitor cells (EPCs) play an important role in repairing endothelial injury. | 22018014 |
| Encephalitis | Stem Cell Exhaustion | Altogether in 15/32 (47%) of the cases the clinician had a strong suspicion of cause other than EBV for the patients' CNS symptoms/findings.Of note, 7 of 11 (64%) patients with stem cell transplantation had encephalitis (univariate odds ratio 5.6; confidence Interval 1.1-27.4). | 22018204 |
| Encephalitis | Stem Cell Exhaustion | EBV seems to be associated with encephalitis in stem cell transplant recipients. | 22018204 |
| Malignant neoplasm of stomach, Specialty Type - cancer | Stem Cell Exhaustion | Combination of epithelial-mesenchymal transition and cancer stem cell-like phenotypes has independent prognostic value in gastric cancer. | 22018628 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | To demonstrate the clinical significance of epithelial-mesenchymal transition and stem cell-like phenotypes in gastric cancer, we performed immunohistochemistry for 5 epithelial-mesenchymal transition-related proteins, including Snail-1, ZEB-1, E-cadherin, vimentin, and b-catenin, and the gastric cancer stem cell marker CD44 in 276 consecutive primary gastric cancers and 54 matched lymph node metastases. | 22018628 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | The known gastric cancer stem cell maker, CD44, was significantly associated with the protein expression of Snail-1, ZEB-1, and E-cadherin (P < .05). | 22018628 |
| Aggressive behavior, Primary malignant neoplasm | Stem Cell Exhaustion | A combination of epithelial-mesenchymal transition and stem cell-like phenotypes is an important predictor of aggressive biologic behavior and has an independent prognostic value in predicting outcomes of primary gastric cancer. | 22018628 |
| Bladder Neoplasm, Neoplasms | Stem Cell Exhaustion | We experienced a case of urinary bladder tumor diagnosed as osteoclastic-rich undifferentiated carcinoma, and performed an immunohistochemical study on the expression of various markers, including stem cell markers to further characterize the tumor properties. | 22019007 |
| Hormone refractory prostate cancer | Stem Cell Exhaustion | Phase I rapid dose-escalation study of AGS-1C4D4, a human anti-PSCA (prostate stem cell antigen) monoclonal antibody, in patients with castration-resistant prostate cancer: a PCCTC trial. | 22020316 |
| Malignant neoplasm of prostate | Stem Cell Exhaustion | AGS-1C4D4 is a human monoclonal antibody against prostate stem cell antigen (PSCA), a cell-surface protein expressed by most prostate cancers. | 22020316 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Hematopoietic stem cell transplant following remission induction chemotherapy including gemtuzumab ozogamicin is a feasible and effective treatment option in elderly patients with acute myeloid leukemia. | 22023488 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | This study analyzed the results of stem cell transplant (SCT) in elderly patients with acute myeloid leukemia (AML) who achieved complete remission (CR) with a gemtuzumab ozogamicin (GO)-containing regimen in order to identify the impact of the drug as a remission induction regimen on the outcome of SCT. | 22023488 |
| Multiple Myeloma | Stem Cell Exhaustion | The prognostic impact of chromosomal abnormalities was evaluated by fluorescence in situ hybridization with cytoplasmic immunoglobulin light chain staining (cIg-FISH) and by classical metaphase cytogenetics in a cohort of 207 patients with newly diagnosed multiple myeloma who were treated with high-dose therapy followed by autologous stem cell transplantation in the CMG2002 clinical trial. | 22023516 |
| Multiple Myeloma | Stem Cell Exhaustion | In conclusion, complex karyotype, gain of 1q21 region and translocation t(4;14) are major prognostic factors associated with reduced survival of patients with newly diagnosed multiple myeloma treated with autologous stem cell transplantation. | 22023516 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | High-dose therapy and autologous stem cell transplant for transformed non-Hodgkin lymphoma in the rituximab era. | 22023518 |
| Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | The impact of rituximab on the outcome of high-dose therapy and autologous stem cell transplant (HD-ASCT) for transformed non-Hodgkin lymphoma (NHL) has not been previously described. | 22023518 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | Upfront thiotepa, busulfan, cyclophosphamide, and autologous stem cell transplantation for primary CNS lymphoma: a single centre experience. | 22023529 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | In an attempt to improve upon these poor results, we treated 21 patients with PCNSL aged 34-69 years (median 56) with high-dose thiotepa, busulfan, cyclophosphamide (TBC) and autologous stem cell transplant (ASCT) as part of front-line therapy, without WBRT. | 22023529 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Heterogeneity of leukemia stem cell candidates at diagnosis of acute myeloid leukemia and their clinical significance. | 22024109 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Leukemia stem cell candidates (LSCC) can be enriched from patients with acute myeloid leukemia by high aldehyde dehydrogenase (ALDH) activity and CD34 expression. | 22024109 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | Valganciclovir as pre-emptive therapy for cytomegalovirus infection in allogeneic haematopoietic stem cell transplant recipients. | 22024510 |
| Communicable Diseases | Stem Cell Exhaustion | In haematopoietic stem cell transplant (HSCT) recipients, cytomegalovirus (CMV) infection contributes significantly to morbidity and mortality in both the early and late post-transplant period. | 22024510 |
| Malignant Neoplasms | Stem Cell Exhaustion | Polycomb group (PcG) proteins are critical epigenetic mediators of stem cell pluripotency, which have been implicated in the pathogenesis of human cancers. | 22028491 |
| Pulmonary Complication | Stem Cell Exhaustion | Pulmonary function testing prior to reduced intensity conditioning allogeneic stem cell transplantation in an unselected patient cohort predicts posttransplantation pulmonary complications and outcome. | 22031451 |
| Hodgkin Disease | Stem Cell Exhaustion | The prognosis of patients with relapsed Hodgkin's lymphoma, especially those who relapse after stem-cell transplantation, is poor, and the development of new agents for this patient population is an unmet medical need. | 22033282 |
| Hodgkin Disease | Stem Cell Exhaustion | Successful administration of rituximab-bendamustine regimen in the relapse of Hodgkin lymphoma after autologous hemopoietic stem cell transplantation. | 22034208 |
| Hodgkin Disease, LIPC gene | Stem Cell Exhaustion | Treatment options for relapsing Hodgkin lymphoma (HL) are controversial after autologous hemopoietic stem cell transplantation (HSCT). | 22034208 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Four years previous to his admission to our hospital, he developed acute myelocytic leukemia and he was implanted with peripheral blood stem cell transplantation. | 22036822 |
| Neutropenia | Stem Cell Exhaustion | We have used a mathematical model of the combined dynamics of the hematopoietic stem cells and the differentiated neutrophil progeny to examine the effects of periodic chemotherapy in generating neutropenia, and the corresponding response of this system to granulocyte colony stimulating factor given to counteract the neutropenia. | 22037060 |
| Specialty Type - cancer | Stem Cell Exhaustion | Furthermore, neoplastic transformation involves senescence evasion, and is associated with an increased number of putative cancer stem cells. | 22037217 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Distinct patterns of promoter CpG island methylation of breast cancer subtypes are associated with stem cell phenotypes. | 22037257 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Although DNA methylation profiles in breast cancer have been connected to breast cancer molecular subtype, there have been no studies of the association of DNA methylation with stem cell phenotype. | 22037257 |
| Childhood Breast Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | This study was designed to evaluate the promoter CpG island methylation of 15 genes in relation to breast cancer subtype, and to investigate whether the patterns of CpG island methylation in each subtype are associated with their cancer stem cell phenotype represented by CD44+/CD24- and ALDH1 expression. | 22037257 |
| SCGB3A1 gene, Atrial Premature Complexes, Childhood Breast Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | We performed MethyLight analysis of the methylation status of 15 promoter CpG island loci involved in breast cancer progression (APC, DLEC1, GRIN2B, GSTP1, HOXA1, HOXA10, IGF2, MT1G, RARB, RASSF1A, RUNX3, SCGB3A1, SFRP1, SFRP4, and TMEFF2) and determined cancer stem cell phenotype by CD44/CD24 and ALDH1 immunohistochemistry in 36 luminal A, 33 luminal B, 30 luminal-HER2, 40 HER2 enriched, and 40 basal-like subtypes of breast cancer. | 22037257 |
| Childhood Breast Carcinoma, Malignant neoplasm of breast, Neoplasms | Stem Cell Exhaustion | Our findings showed that promoter CpG island methylation was different in relation to breast cancer subtype and stem cell phenotype of tumor, suggesting that breast cancers have distinct patterns of CpG island methylation according to molecular subtypes and these are associated with different stem cell phenotypes of the tumor. | 22037257 |
| Post-transplant lymphoproliferative disorder | Stem Cell Exhaustion | Post-transplant lymphoproliferative disorder (PTLD) is a fatal complication of allogeneic hematopoietic stem cell transplantation (HSCT) that is caused by reactivation of Epstein-Barr virus (EBV). | 22038015 |
| methyldopa | Stem Cell Exhaustion | Retinal pigment epithelium (RPE) cells derived from human embryonic stem cells (hES-RPE) and cultured fetal and aged adult RPE were seeded onto the inner collagenous layer of submacular BM-choroid-sclera explants generated from aged and AMD human donor eyes. | 22039244 |
| Ischemia | Stem Cell Exhaustion | Early endothelial progenitor cells in bone marrow are a biomarker of cell therapy success in patients with critical limb ischemia. | 22040109 |
| CLU protein, human, Ischemia | Stem Cell Exhaustion | Early and late endothelial progenitor cells (CFU-EC and ECFC) were cultivated and quantified according to published methods in peripheral blood and BM-MNC from patients with critical limb ischemia (CLI; n = 11) enrolled in the OPTIPEC trial ( http://clinicaltrials.gov/ct2/show/NCT00377897 ) to receive BM-MNC as a cell therapy product. | 22040109 |
| Acute lymphocytic leukemia, BCR gene | Stem Cell Exhaustion | To elucidate the presence of this family on acute lymphoblastic leukemia (ALL), as well as its relationship with the leukemia-initiating potential, we analyzed the expression pattern of this family members on human ALL progenitor cells, combined with serial xenotransplantation assay. | 22040559 |
| Leukemic Blast Count | Stem Cell Exhaustion | SLAM family members are present on B-ALL progenitor cells and the leukemia-initiating potential of leukemic blasts is correlated negatively with the proportion of CD(150)(+) cells, the percentage of which can serve as a useful predictor for engraftment success of B-ALL to immune deficient mice. | 22040559 |
| Infection | Stem Cell Exhaustion | During their index admission, patients who were subsequently readmitted had more documented infections (P < .001), higher hematopoietic cell transplantation comorbidity index (HCT-CI) (P < .01), total body irridiation (TBI)-based conditioning (P < .001), unrelated donor (P < .001), and peripheral stem cell (P = .014) transplantation. | 22040844 |
| Myeloproliferative disease, MYELODYSPLASTIC SYNDROME, Myeloid Leukemia, Chronic, Chronic myeloproliferative disorder, Acute lymphocytic leukemia | Stem Cell Exhaustion | The conventional cytogenetic test and detection of BCR/ABL fusion gene by FISH for bone marrow of patients with newly diagnosed chronic myeloproliferative disease or myelodysplastic and myeloproliferative disorders, acute lymphocytic leukemia and chronic myelogenous leukemia (CML) after allogeneic hematopoietic stem cell transplantation were carried out. | 22040989 |
| Myeloproliferative disease, MYELODYSPLASTIC SYNDROME, Myeloid Leukemia, Chronic, Chronic myeloproliferative disorder, Acute lymphocytic leukemia | Stem Cell Exhaustion | The results showed that (1) out of 46 newly diagnosed as chronic myeloproliferative disease or myelodysplastic and myeloproliferative disorders, 22 cases were diagnosed as CML, the FISH detection showed all positive (100%), while cytogenetic test showed 86.4% (19/22) positive, in the other 24 patients who were diagnosed as other chronic myeloproliferative disease or myelodysplastic and myeloproliferative disorders, BCR/ABL fusion gene all were be detected as negative 100% by FISH, while the cytogenetic test of bone marrow in 3 cases supported the diagnosis of CML, and the diagnosis of myelodysplastic disorder in 1 case; (2) in 3 out of 7 acute lymphocytic leukemia cases the BCR/ABL fusion gene could not be detected by FISH; (3) the BCR/ABL fusion gene could be detected by FISH in 2 cases of CML received allogeneic hematopoietic stem cell transplantation, with abnormal threshold 6.5% and 1.2% respectively. | 22040989 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | This method also has an important significance for monitor of minimal residual disease in CML patients received allogeneic hematopoietic stem cell transplantation. | 22040989 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | Outcome of medium-dose VP-16/CY/TBI superior to CY/TBI as a conditioning regimen for allogeneic stem cell transplantation in adult patients with acute lymphoblastic leukemia. | 22042561 |
| Acute lymphocytic leukemia, BCR gene | Stem Cell Exhaustion | The choice of conditioning regimen before allogeneic stem cell transplantation (SCT) in patients with acute lymphoblastic leukemia (ALL) is important. | 22042561 |
| Communicable Diseases | Stem Cell Exhaustion | An in vitro study confirmed the enhanced neurogenesis of mouse neural stem cells by direct AAV2/1-FGF2 infection in an Ab oligomer-sensitive manner. | 22042871 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | The samples in cluster 1 also share many features with the newly identified claudin-low breast cancer intrinsic subtype, which also shows characteristics of stromal and stem cells. | 22044755 |
| Gastrointestinal symptom | Stem Cell Exhaustion | Human herpesvirus 6 in biopsies from patients with gastrointestinal symptoms after allogeneic stem cell transplantation. | 22048789 |
| Gastrointestinal complication | Stem Cell Exhaustion | Gastrointestinal complications are frequent after allogeneic stem cell transplantation (allo-SCT). | 22048789 |
| Disease, trauma qualifier | Stem Cell Exhaustion | Non-embryonic stem cells have the potential for being used in therapeutic attempts to develop treatments for human diseases and injuries. | 22049618 |
| Degenerative polyarthritis, Burn injury, Rheumatoid Arthritis, Diabetes, Cerebrovascular accident, Spinal Cord Injuries, Heart Diseases, Parkinson Disease | Stem Cell Exhaustion | Simple, secure methods to isolate non-embryonic stem cells from different tissues is one step towards making those treatments available to people suffering from Parkinson's disease, spinal cord injury, stroke, burns, heart disease, diabetes, osteoarthritis, and rheumatoid arthritis. | 22049618 |
| Specialty Type - cancer, Squamous cell carcinoma of esophagus | Stem Cell Exhaustion | An immunohistochemical analysis of cancer stem cell markers, such as nucleostemin and TWIST has not been conducted in surgically-resected esophageal squamous cell carcinomas after neoadjuvant chemotherapy. | 22050045 |
| Neoplasms | Stem Cell Exhaustion | More specifically, cells that constitutively express elevated levels of nucleostemin exhibit increased TWIST expression; expression of genes that induced pluripotent stem cells; enhanced radioresistance; tumor formation, even when small numbers of cells are implanted; and an increased propensity to metastasize. | 22050045 |
| Precursor T cell lymphoblastic leukemia/lymphoblastic lymphoma | Stem Cell Exhaustion | Distinct immunophenotype of early T-cell progenitors in T lymphoblastic leukemia/lymphoma may predict FMS-like tyrosine kinase 3 mutations. | 22050963 |
| Amyloidosis | Stem Cell Exhaustion | All patients with light-chain amyloidosis received chemotherapy in the interval between OHT and autologous hematopoietic stem cell transplant. | 22051505 |
| Amyloidosis | Stem Cell Exhaustion | A novel strategy of OHT, followed by light-chain suppressive chemotherapy before autologous hematopoietic stem cell transplant, is feasible for patients with light-chain amyloidosis. | 22051505 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Adventitial delivery of an allogeneic bone marrow-derived adherent stem cell in acute myocardial infarction: phase I clinical study. | 22052917 |
| Acute myocardial infarction | Stem Cell Exhaustion | MultiStem is an allogeneic bone marrow-derived adherent adult stem cell product that has shown efficacy in preclinical models of acute myocardial infarction (AMI). | 22052917 |
| Special Handling Code - Dry | Stem Cell Exhaustion | Comparison of stem cell sources in the severity of dry eye after allogeneic haematopoietic stem cell transplantation. | 22053104 |
| Dry Eye Syndromes | Stem Cell Exhaustion | To compare the incidence and severity of dry eye (DE) after allogeneic haematopoietic stem cell transplantation (HSCT) according to the stem cell source. | 22053104 |
| Lymphoid, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Successful treatment of lymphoid blastic crisis in chronic myelogenous leukemia with the additional bcr/abl transcript using imatinib-combined chemotherapy and high-dose chemotherapy with allogeneic bone marrow stem cell transplantation. | 22057509 |
| Neutropenia, Hematologic Neoplasms, Mycoses | Stem Cell Exhaustion | Based on the high negative predictive value of this diagnostic and therapeutic approach in persistent febrile neutropenia patients with hematologic malignancies or patients who have received a hematopoietic stem cell transplant, the approach is useful for identifying patients who are not likely to develop invasive fungal infection and do not, therefore, require antifungal therapy. | 22058202 |
| Multiple Myeloma | Stem Cell Exhaustion | Cyclophosphamide, thalidomide, and dexamethasone as induction therapy for newly diagnosed multiple myeloma patients destined for autologous stem-cell transplantation: MRC Myeloma IX randomized trial results. | 22058209 |
| Myelosuppression, Multiple Myeloma | Stem Cell Exhaustion | Thalidomide is active in multiple myeloma and is associated with minimal myelosuppression, making it a good candidate for induction therapy prior to high-dose therapy with autologous stem-cell transplantation. | 22058209 |
| Multiple Myeloma | Stem Cell Exhaustion | Younger donor's age and upfront tandem are two independent prognostic factors for survival in multiple myeloma patients treated by tandem autologous-allogeneic stem cell transplantation: a retrospective study from the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire (SFGM-TC). | 22058218 |
| Multiple Myeloma | Stem Cell Exhaustion | How tandem autologous-allogeneic stem cell transplantation should be integrated in the treatment of multiple myeloma remains controversial. | 22058218 |
| Multiple Myeloma | Stem Cell Exhaustion | We examined the long-term outcome of patients with multiple myeloma managed with tandem autologous-allogeneic stem cell transplantation and present a prognostic factor analysis based on the experience of the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire (SFGM-TC). | 22058218 |
| Multiple Myeloma | Stem Cell Exhaustion | Benefit from autologous stem cell transplantation in primary refractory myeloma? | 22058223 |
| Multiple Myeloma | Stem Cell Exhaustion | Several studies of autologous stem cell transplantation in primary refractory myeloma have produced encouraging results. | 22058223 |
| Nephroblastoma | Stem Cell Exhaustion | Renal function after tandem high-dose chemotherapy and autologous stem cell transplantation in children with Wilms tumor. | 22060039 |
| Multiple Myeloma | Stem Cell Exhaustion | Second autologous stem cell transplantation as salvage therapy for multiple myeloma: impact on progression-free and overall survival. | 22062804 |
| Multiple Myeloma | Stem Cell Exhaustion | The role of a second autologous stem cell transplant (ASCT) as salvage therapy is unclear, particularly with the availability of novel agents to treat progressive multiple myeloma (MM). | 22062804 |
| Skeletal muscle structure, muscle cell proliferation | Stem Cell Exhaustion | It inhibits muscle stem cell proliferation and differentiation and attenuates adult muscle fiber protein accretion, resulting in decreased skeletal muscle mass. | 22068480 |
| Secondary malignant neoplasm of liver, Specialty Type - cancer | Stem Cell Exhaustion | Prognostic value of putative circulating cancer stem cells in patients undergoing hepatic resection for colorectal liver metastasis. | 22071867 |
| Malignant tumor of colon | Stem Cell Exhaustion | Univariate analysis of the expression levels of CD133 (a marker of colon cancer stem cells) and survivin (an antiapoptotic factor) resulted in statistically significant association with patient survival [hazard ratio (HR) 2.7, 95% confidence interval (CI) 1.9-3.7, P < 0.0001; and hazard ratio 2.1, 95% CI 1.4-3.2, P < 0.0001, respectively]. | 22071867 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | The application of allogeneic hematopoietic stem cell transplantation (HSCT) is limited by life-threatening complications such as severe or acute graft-versus-host disease (GVHD). | 22073847 |
| Parkinson Disease | Stem Cell Exhaustion | In this study, we examined the subventricular zone of 10 patients with Parkinson's disease and 10 age- and sex-matched controls for proliferation and neural stem cell numbers. | 22075520 |
| Parkinsonian Disorders, Parkinson Disease | Stem Cell Exhaustion | In summary, the adult neural stem cell pool in the subventricular zone was not clearly affected in the human parkinsonian brain or a Parkinson's disease mouse model. | 22075520 |
| Impaired, Parkinson Disease | Stem Cell Exhaustion | An impairment in neurogenesis may have negative consequences for the development of new therapeutic approaches in Parkinson's disease, as neural stem cells are a potential source for endogenous repair. | 22075520 |
| Parkinson Disease | Stem Cell Exhaustion | Additionally, we were able to culture neural stem cells from post-mortem brain of several patients with Parkinson's disease, confirming the presence of viable neural stem cells in these brains. | 22075520 |
| Parkinsonian Disorders | Stem Cell Exhaustion | Thus, we conclude that the number of adult neural stem cells is probably not diminished in the parkinsonian brain and that dopamine depletion most likely has no effect on human neural stem cells. | 22075520 |
| Parkinson Disease | Stem Cell Exhaustion | The induction of rat spermatogonial stem cells into neuronal-like cells and behavioral recovery following transplantation in a rat Parkinson's disease model. | 22075704 |
| Injury of kidney, Amyloidosis | Stem Cell Exhaustion | Acute kidney injury during leukocyte engraftment after autologous stem cell transplantation in patients with light-chain amyloidosis. | 22076913 |
| Exanthema, Fever, Engraftment syndrome, Non-cardiogenic pulmonary edema | Stem Cell Exhaustion | Engraftment syndrome (ES) is a complication of hematopoietic stem cell transplantation characterized by fever, rash, and non-cardiogenic pulmonary edema. | 22076913 |
| Kidney Failure, Acute, Amyloidosis | Stem Cell Exhaustion | We have noted a high incidence of AKI in patients with immunoglobulin light-chain amyloidosis (AL) undergoing autologous stem cell transplant (ASCT) around the time of leukocyte engraftment. | 22076913 |
| Cytomegalovirus Infections, Lymphoma | Stem Cell Exhaustion | The potential role of pre-transplant HBcIgG seroposivity as predictor of clinically relevant cytomegalovirus infection in patients with lymphoma undergoing autologous hematopoietic stem cell transplantation: a study from the Rome Transplant Network. | 22076952 |
| Lymphoma, Communicable Diseases | Stem Cell Exhaustion | Despite the increased use of intensive immunosuppressive chemo-immunotherapies in patients with lymphoma observed in the last decade, current data on cytomegalovirus (CMV) infection following autologous stem cell transplantation (Auto-SCT) are very limited. | 22076952 |
| Ischemia | Stem Cell Exhaustion | Therapeutic angiogenesis in patients with severe limb ischemia by transplantation of a combination stem cell product. | 22079876 |
| Malignant neoplasm of ovary, Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | As a putative marker for cancer stem cells in human malignant tumors, including ovarian cancer, CD133 expression may define a tumor-initiating subpopulation of cells and is associated with the clinical outcome of patients. | 22080056 |
| Malignant neoplasm of ovary, Specialty Type - cancer | Stem Cell Exhaustion | Our results thus show that CD133 expression is a predictor of poor clinical outcome for patients with ovarian cancer, supporting the proposed link between CD133 and cancer stem cells. | 22080056 |
| Secondary Neoplasm | Stem Cell Exhaustion | During tumorigenesis, epithelial to mesenchymal transition promotes invasion and metastasis and has been linked to the presence of stem cells. | 22080057 |
| Malignant neoplasm of ovary, Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cell and embryonic development-associated molecules contribute to prognostic significance in ovarian cancer. | 22080880 |
| Specialty Type - cancer | Stem Cell Exhaustion | Embryonic molecules and cancer stem cell signaling resemble each other, and they organize cancer modality. | 22080880 |
| Hodgkin Disease, Lymphoma, Non-Hodgkin, Multiple Myeloma | Stem Cell Exhaustion | European data on stem cell mobilization with plerixafor in non-Hodgkin's lymphoma, Hodgkin's lymphoma and multiple myeloma patients. | 22080971 |
| Specialty Type - cancer | Stem Cell Exhaustion | Nucleostemin (NS), a nucleolar GTPase, is highly expressed in stem/progenitor cells and in most cancer cells. | 22081066 |
| Infection, Hypogammaglobulinemia | Stem Cell Exhaustion | Patients undergoing allogeneic hematopoietic stem cell transplant (allo HCT) have a higher incidence of infections partly due to secondary hypogammaglobulinemia. | 22081487 |
| Graft-vs-Host Disease, Malignant neoplasm of skin | Stem Cell Exhaustion | Recipients of hematopoietic stem cell transplantation (HSCT) have a greater risk of skin cancer; chronic graft versus host disease (GVHD) is an additional risk factor. | 22085032 |
| Sample Size Calculation | Stem Cell Exhaustion | Circulating endothelial progenitor cells (EPC), circulating endothelial cells and serum levels of placental growth factor (PlGF), soluble vascular adhesion molecule and vascular endothelial growth factor were measured in a prospective cohort of 100 SSc patients. | 22085793 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | JmjC-domain containing histone demethylase 1B-mediated p15(Ink4b) suppression promotes the proliferation of leukemic progenitor cells through modulation of cell cycle progression in acute myeloid leukemia. | 22086844 |
| Myeloproliferative disease | Stem Cell Exhaustion | ET is a clonal stem cell disorder that is often associated with JAK2 mutations and shares phenotypic and pathogenetic similarities with other myeloproliferative neoplasms. | 22088920 |
| Coronary Vessel Bifurcation Lesion | Stem Cell Exhaustion | Thus, aim of the present study was to evaluate the angiographic and clinical results of a new type of stent (coated with murine monoclonal antihuman CD34 antibodies designed to attract circulating endothelial progenitor cells to rapidly establish a functional endothelial layer and promote healing stent implantation) in a cohort of consecutive patients with coronary bifurcation lesions. | 22089276 |
| Hematopoietic Neoplasms, Loss | Stem Cell Exhaustion | Analysis of hematopoietic stem cell transplant engraftment: use of loss or gain of microsatellite alleles to identify residual hematopoietic malignancy. | 22089346 |
| Neoplasms, leukemia | Stem Cell Exhaustion | In the peripheral blood or bone marrow of 4 hematopoietic stem cell transplantation patients with leukemia or lymphoma, we identified tumor DNA on the basis of STR loci showing copy number alteration. | 22089346 |
| Ann Arbor Stage I Nasal Type NK/T-Cell Lymphoma | Stem Cell Exhaustion | We report the first case of successful treatment with chemoradiotherapy and autologous stem cell transplantation in a patient with a primary spinal NK/T-cell lymphoma. | 22089400 |
| Hematopoietic stem cells, PAFAH1B1 wt Allele, leukemia, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Myelodysplastic syndrome (MDS) is a clonal haematopoietic stem cell disorder characterized by ineffective haematopoiesis and leukaemia progression. | 22089606 |
| Immunocompromised Host | Stem Cell Exhaustion | In 24 patients for whom clinical data were available, results from the 16S rRNA sequencing method led to treatment change in 14 immunocompromised patients (including 7 hematopoietic stem cell recipients and 1 liver transplant recipient). | 22093075 |
| Optic Neuritis | Stem Cell Exhaustion | Presumed cytomegalovirus-associated retrobulbar optic neuritis in a patient after allogeneic stem cell transplantation. | 22093546 |
| Optic Neuritis | Stem Cell Exhaustion | A case of cytomegalovirus (CMV)-associated bilateral retrobulbar optic neuritis (ON) following haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is reported. | 22093546 |
| Immunocompromised Host, Communicable Diseases | Stem Cell Exhaustion | There are several reports in the literature of M. marinum infection in immunocompromised hosts, including those with solid organ transplants, but none in patients who have received stem cell transplants (SCTs). | 22093773 |
| Liver carcinoma | Stem Cell Exhaustion | MRI features of hepatocellular carcinoma expressing progenitor cell markers. | 22097930 |
| Liver carcinoma, HCCS gene | Stem Cell Exhaustion | To determine whether magnetic resonance (MR) imaging features differ between hepatocellular carcinomas (HCCs) with and without expression of progenitor cell markers, such as cytokeratin (CK) 19 and epithelial cell adhesion molecule (EpCAM). | 22097930 |
| Specialty Type - cancer, Squamous cell carcinoma of esophagus, Secondary Neoplasm | Stem Cell Exhaustion | Cancer stem cell marker ALDH1 expression is associated with lymph node metastasis and poor survival in esophageal squamous cell carcinoma: a study from high incidence area of northern China. | 22098156 |
| Specialty Type - cancer, Aggressive behavior, Neoplasms | Stem Cell Exhaustion | Cancer stem cell (CSC) may be responsible for tumor growth and maintenance of aggressive behavior. | 22098156 |
| Stable chronic Graft vs Host Disease, Infection | Stem Cell Exhaustion | Aiming to determine the impact of lymphocyte subsets on cGVHD, blood samples from 98 patients at least 100 days following allogeneic haematopoietic stem cell transplantation (median 1066 days) were analyzed, serum levels of immunoglobulins measured and the incidence of severe infections retrospectively documented. | 22098606 |
| Adult Glioblastoma, Specialty Type - cancer | Stem Cell Exhaustion | Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethane-short branch PEI. | 22098779 |
| Malignant - descriptor, Specialty Type - cancer | Stem Cell Exhaustion | CD133 has been considered a putative marker of cancer stem cells (CSCs) in malignant cancers, including GBMs. | 22098779 |
| melanoma, Specialty Type - cancer | Stem Cell Exhaustion | Correlates of BBCAM use included cancer type (bowel [OR=3.3; CI:1.8-5.9], breast [OR=2.4; CI:1.4-4.1], head and neck [OR=3.8; CI: 2.0-7.2], haematological [OR=2.0; CI: 1.1-3.7], prostate [OR=1.8; CI: 1.0-3.9] versus melanoma), education level (university degree [OR=1.6; CI:1.1-2.3] versus secondary school) and treatment types (chemotherapy [OR=2.0; CI:1.4-2.7] versus not, bone marrow/stem cell transplant/immunotherapy [OR=2.3; CI:1.2-4.4] versus not). | 22100734 |
| Specialty Type - cancer | Stem Cell Exhaustion | Moreover, it is a marker for cancer stem cells (CSC). | 22101256 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | BCR-ABL overexpression and stem cell quiescence supposedly contribute to the failure of imatinib mesylate (IM) to eradicate chronic myeloid leukemia (CML). | 22101898 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Detection of minimal residual disease following induction immunochemotherapy was an independent predictor of time to progression following immunochemotherapy and autologous stem cell transplantation for mantle cell lymphoma. | 22102709 |
| Hematopoietic Neoplasms, Opportunistic Infections | Stem Cell Exhaustion | The number of patients with haematopoietic malignancies receiving chemotherapy and stem-cell transplantation has increased the incidence of severe opportunistic infections. | 22103628 |
| Parkinson Disease | Stem Cell Exhaustion | We present two case studies where this software is currently being used to build repositories of genomics experiments - one contains data from hematopoietic stem cells and another from Parkinson's disease patients. | 22103807 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Early remodeling processes as predictors of diastolic function 5 years after reperfused acute myocardial infarction and intracoronary progenitor cell application. | 22105229 |
| Infarction | Stem Cell Exhaustion | Adverse early remodeling processes (reflected by LV dilatation between infarction and 4 months) determine long-term diastolic function in patients after reperfused AMI and progenitor cell therapy. | 22105229 |
| Cocaine-Related Disorders | Stem Cell Exhaustion | Somatic cells reprogrammed into induced pluripotent stem cells (iPSCs) acquire features of human embryonic stem cells (hESCs) and thus represent a promising source for cellular therapy of debilitating diseases, such as age-related disorders. | 22110631 |
| Malignant neoplasm of breast, Neoplasms | Stem Cell Exhaustion | Breast cancers from BRCA mutation carriers do not harbor more ALHD-1 positive cells than sporadic tumors, and their more aggressive phenotype can thus not be explained by an increased stem cell pool. | 22111833 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Presence of intratumoral stem cells in breast cancer patients with or without BRCA germline mutations. | 22111833 |
| Non-Malignant | Stem Cell Exhaustion | While mammary stem cells were also detected in non-malignant breast lesions, only 41% of the tissues contained ALDH-1 positive cells (p=0.0371, Chi Square test). | 22111833 |
| Neoplasms | Stem Cell Exhaustion | We have investigated the presence of mammary stem / progenitor cells in normal tissues and in tumor tissues obtained from women with and without BRCA1/2 germline mutations by utilizing ALDH-1 immunohistochemistry. | 22111833 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | Cancer stem cell markers in breast cancer: pathological, clinical and prognostic significance. | 22112299 |
| Specialty Type - cancer, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | The cancer stem cell (CSC) hypothesis states that tumours consist of a cellular hierarchy with CSCs at the apex driving tumour recurrence and metastasis. | 22112299 |
| Hematological Disease, Malignant Neoplasms | Stem Cell Exhaustion | Cases were analyzed for time from diagnosis to referral, age, race, gender, socioeconomic status, antecedent hematologic disorder, cytotoxic or radiation therapy for prior malignancy, karyotype, fms-like tyrosine kinase receptor-3 (FLT3) mutations, intensive chemotherapy, clinical trial participation, hematopoietic stem cell transplantation (HSCT) and overall survival (OS). | 22112974 |
| Multiple Myeloma | Stem Cell Exhaustion | 18F-FDG PET/CT for detection and localization of residual or recurrent disease in patients with multiple myeloma after stem cell transplantation. | 22113619 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | The aim of the study was to determine the diagnostic performance of (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT for the detection and localization of residual or recurrent disease in patients with multiple myeloma (MM) after stem cell transplantation. | 22113619 |
| hyperfunction, Aspergillosis | Stem Cell Exhaustion | Genetically-determined hyperfunction of the S100B/RAGE axis is a risk factor for aspergillosis in stem cell transplant recipients. | 22114731 |
| Aspergillosis | Stem Cell Exhaustion | Invasive aspergillosis (IA) is a major threat to the successful outcome of hematopoietic stem cell transplantation (HSCT), although individual risk varies considerably. | 22114731 |
| Non-Small Cell Lung Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | A tissue microarray representing 248 clinically annotated stage I-II NSCLC cases was stained using immunohistochemistry (IHC) and scored for HHSP proteins namely, SHH, PTCH1, SMO, GLI1, and GLI2; as well as, ALDH1A1, a putative cancer stem cell marker. | 22115706 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | Long-term follow-up of high-dose chemotherapy with autologous stem-cell transplantation and response-adapted whole-brain radiotherapy for newly diagnosed primary CNS lymphoma: results of the multicenter Ostdeutsche Studiengruppe Hamatologie und Onkologie OSHO-53 phase II study. | 22115927 |
| Primary central nervous system lymphoma, Peripheral Stem Cell Transplantation | Stem Cell Exhaustion | We previously reported the results of a phase II study for patients with newly diagnosed primary central nervous system lymphoma treated with autologous peripheral blood stem-cell transplantation (aPBSCT) and response-adapted whole-brain radiotherapy (WBRT). | 22115927 |
| leukemia | Stem Cell Exhaustion | Hematopoietic stem cell transplantation in T-prolymphocytic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation and the Royal Marsden Consortium. | 22116553 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | Predictors of circulating endothelial progenitor cell levels in patients without known coronary artery disease referred for multidetector computed tomography coronary angiography. | 22118125 |
| Diabetes, Coronary Arteriosclerosis | Stem Cell Exhaustion | Relation between the frequency of CD34+ bone marrow derived circulating progenitor cells and the number of diseased coronary arteries in patients with myocardial ischemia and diabetes. | 22118372 |
| Coronary heart disease | Stem Cell Exhaustion | Bone marrow-derived circulating progenitor cells (BM-CPCs) in patients with coronary heart disease are impaired with respect to number and mobilization. | 22118372 |
| SERPINB3 wt Allele, Specialty Type - cancer, Squamous cell carcinoma | Stem Cell Exhaustion | The utility of CD44, CD117 and CD133 in identification of cancer stem cells (CSC) in oral squamous cell carcinomas (OSCC). | 22119814 |
| Neoplasms, Specialty Type - cancer, Carcinogenesis | Stem Cell Exhaustion | One of the theories regarding oral carcinogenesis is that the tumor growth is dependent on cancer stem cells (CSCs) that have the capacity of self-renewal and of giving rise to more differentiated tumor cells, like the stem cells do in normal tissues. | 22119814 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | This shows that the relationship between basic cell biology and clinical behaviour is not always straightforward and warrants further investigations of the true clinical impact of breast cancer stem cells. | 22119938 |
| Peripheral Arterial Diseases | Stem Cell Exhaustion | Number of endothelial progenitor cells in peripheral artery disease as a marker of severity and association with pentraxin-3, malondialdehyde-modified low-density lipoprotein and membrane type-1 matrix metalloproteinase. | 22123215 |
| Heart failure, Coronary Arteriosclerosis, Vascular System Injuries, Corneal Endothelial Cell Loss | Stem Cell Exhaustion | Circulating endothelial progenitor cells (EPCs) were mobilized in cardiac ischemia, heart failure and vascular injuries associated with endothelial damage. | 22123215 |
| Bacteremia, Meningitis | Stem Cell Exhaustion | A 53-year-old stem cell transplant recipient with meningitis and bacteremia. | 22124018 |
| Multiple Myeloma | Stem Cell Exhaustion | A 71-year-old woman with multiple myeloma status after stem cell transplantation. | 22125317 |
| granulocyte, Cervical Intraepithelial Neoplasia, Adult chronic idiopathic neutropenia | Stem Cell Exhaustion | Chronic idiopathic neutropenia (CIN) is a granulocytic disorder characterized by increased apoptosis of the bone marrow (BM) granulocytic progenitor cells and an inflammatory BM microenvironment. | 22127462 |
| Multiple Myeloma | Stem Cell Exhaustion | High-risk cytogenetics and persistent minimal residual disease by multiparameter flow cytometry predict unsustained complete response after autologous stem cell transplantation in multiple myeloma. | 22128143 |
| Multiple Myeloma | Stem Cell Exhaustion | The achievement of complete response (CR) after high-dose therapy/autologous stem cell transplantation (HDT/ASCT) is a surrogate for prolonged survival in multiple myeloma; however, patients who lose their CR status within 1 year of HDT/ASCT (unsustained CR) have poor prognosis. | 22128143 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | According to the cancer stem cell (CSC) hypothesis, only a small subset of tumor cells has the ability to initiate and develop tumor growth. | 22130902 |
| SERPINB3 wt Allele, Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | MiRNA expression and DNA methylation changes were also investigated in FACS sorted CD44(high) oral cancer stem cells from primary tumor samples (CSCs), and in oral rinse and saliva from 15 OSCC patients and 7 healthy volunteers. | 22132151 |
| Pneumonitis, CTCAE | Stem Cell Exhaustion | Risk factors for development of pneumonitis after high-dose chemotherapy with cyclophosphamide, BCNU and etoposide followed by autologous stem cell transplant. | 22132836 |
| Pneumonitis, CTCAE | Stem Cell Exhaustion | Pneumonitis is a complication of high-dose chemotherapy and autologous stem cell transplant (HDC-ASCT) regimens containing BCNU. | 22132836 |
| Hematologic Neoplasms, Acute GVH disease | Stem Cell Exhaustion | We examined the levels of 33 cytokines in relation to peri- and post-transplant events such as conditioning regimen, chimerism, and acute graft-versus-host disease in myeloablative, non-T cell-replete HLA-identical sibling donor stem cell transplantation for hematologic malignancies. | 22133778 |
| Aniridia, Burn injury | Stem Cell Exhaustion | Primary KPro procedures were performed in 23% of eyes for limbal stem cell deficiency secondary to chemical burns and aniridia and for herpetic disease. | 22134402 |
| Gastric Adenocarcinoma | Stem Cell Exhaustion | Clinicopathologic significance of putative stem cell markers, CD44 and nestin, in gastric adenocarcinoma. | 22135720 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | This is the first study to report the clinicopathologic significance of nestin expression in gastric cancers, and to correlate the nestin expression with CD44, another stem cell marker. | 22135720 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells (CSC) are unique subpopulations that have the capacity to drive malignant progression and mediate radio/chemoresistance. | 22135720 |
| Lymphoma | Stem Cell Exhaustion | Patterns of social support among lymphoma patients considering stem cell transplantation. | 22136347 |
| Lymphoma | Stem Cell Exhaustion | We evaluated the forms of social support available for patients with relapsed lymphoma considering stem cell transplantation and examined the influence of support on treatment delay. | 22136347 |
| T-Cell Lymphoma, allogeneic hematopoietic stem cell transplant with purging | Stem Cell Exhaustion | Long-term survival in patients with peripheral T-cell non-Hodgkin lymphomas after allogeneic hematopoietic stem cell transplant. | 22136377 |
| Histology | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplant may have a role in the treatment of relapsed/refractory disease or high-risk histologies in the upfront setting. | 22136377 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | Patients with primary refractory diffuse large B-cell lymphoma (REF DLBCL: progression on or within 3 months of completion of primary therapy) sensitive to salvage chemotherapy undergo autologous stem cell transplant (ASCT). | 22136378 |
| Cryptococcus | Stem Cell Exhaustion | Disseminated cryptococcal infection in patient with novel JAK3 mutation severe combined immunodeficiency, with resolution after stem cell transplantation. | 22138680 |
| Childhood Non-Hodgkin Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | The aim of this study was to investigate the efficacy of antibiotic prophylaxis in patients undergoing autologous stem cell transplantation (ASCT) for multiple myeloma and non-Hodgkin lymphoma. | 22138805 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | Human endothelial progenitor cells isolated from COPD patients are dysfunctional. | 22139347 |
| Atherosclerosis | Stem Cell Exhaustion | It is accepted that endothelial progenitor cells (EPCs) participate in the repair of dysfunctional endothelium and thus protects against atherosclerosis. | 22139347 |
| Multiple Myeloma | Stem Cell Exhaustion | In this study, we evaluated the association between genetic variations in the VEGF gene in patients with multiple myeloma and time to treatment failure (TTF) after high-dose melphalan and stem cell support (HDT), overall survival (OS) and efficacy of the anti-angiogenic drug thalidomide. | 22139971 |
| Pancreatic intraepithelial neoplasia | Stem Cell Exhaustion | Targeting of oncogenic Kras to the pancreatic Nestin-expressing embryonic progenitor cells and subsequently to the adult acinar compartment and Nestin-expressing cells is sufficient for the development of low grade pancreatic intraepithelial neoplasia (PanIN) between 2 and 4 months. | 22140463 |
| Virus Diseases, Hemorrhagic cystitis | Stem Cell Exhaustion | Prevalence of viral infections and hemorrhagic cystitis in hematopoietic stem cell transplant recipients. | 22142049 |
| Hemorrhagic cystitis | Stem Cell Exhaustion | About 7% to 70% of hemorrhagic cystitis is classified as early and late-onset incidence in hematopoietic stem cell transplant patients. | 22142049 |
| Infection, Hemorrhagic cystitis | Stem Cell Exhaustion | Detection of single and multiple infections of BK virus, adenovirus, and cytomegalovirus in blood and/or urine samples of hematopoietic stem cell transplant recipients, in combination with 1 or more inducing factors of hemorrhagic cystitis were enforced on the important role these risk factors play in the cause of hemorrhagic cystitis. | 22142049 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Although multiple myeloma (MM) remains an incurable disease, considerable improvements in survival have been made with the introduction of autologous stem cell transplantation and new drugs. | 22144117 |
| Primary Adrenal Insufficiency | Stem Cell Exhaustion | Primary adrenal insufficiency in a child after busulfan and cyclophosphamide-based conditioning for hematopoietic stem cell transplantation. | 22145493 |
| Gonadal Disorders | Stem Cell Exhaustion | High rates of skeletal complications, growth disturbances, thyroid and gonadal dysfunction have been described in children undergoing stem cell transplantation. | 22145493 |
| Adrenal cortical hypofunction | Stem Cell Exhaustion | Although secondary adrenal insufficiency has been diagnosed, no primary adrenal insufficiency has been reported after busulfan and cyclophosphamide (Bu/Cy)-based conditioning regimens for stem cell transplantation in children. | 22145493 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | A 9-year-old girl with myelodysplastic syndrome was treated with stem cell transplantation of allogeneic origin. | 22145493 |
| Chronic graft-versus-host disease | Stem Cell Exhaustion | Then, 17 months after stem cell transplantation, chronic graft-versus-host disease developed and was treated with methyl prednisolone for 3 months. | 22145493 |
| Primary Adrenal Insufficiency | Stem Cell Exhaustion | Primary adrenal insufficiency which was observed in our patient after Bu/Cy-based conditioning regimen for stem cell transplantation has not been reported in children and adrenal function should be closely monitored in these patients both before stem cell transplantation and after stem cell transplantation. | 22145493 |
| Neoplasms | Stem Cell Exhaustion | The expression of the liver stem cell markers (c-kit, CD90, CD133 and CK19) in the tumor tissue was detected by immunohistochemistry, and the Kaplan-Meier method was used to evaluate survival. | 22146626 |
| Neoplasms | Stem Cell Exhaustion | The high expression of liver stem cell markers in the tumor tissue suggests that these tumors may derive from liver stem cells. | 22146626 |
| Hematologic Neoplasms | Stem Cell Exhaustion | We conducted a large prospective randomized trial between July 2006 and August 2009 of an art intervention, Open Window (OW), in patients undergoing stem cell transplantation for a hematological malignancy compared with a control group. | 22147646 |
| Amyloidosis | Stem Cell Exhaustion | High-dose melphalan and peripheral blood stem cell transplantation for light-chain amyloidosis with cardiac involvement. | 22147893 |
| Amyloidosis | Stem Cell Exhaustion | High-dose melphalan (HDM) plus stem cell transplantation is an effective treatment for light-chain amyloidosis (AL), but is associated with high treatment-related mortality in patients with cardiac involvement. | 22147893 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Disparity of minor histocompatibility antigens (mHAs) is known to induce graft-versus-tumor and graft-versus-host disease reactions in stem cell transplantation. | 22150369 |
| Thrombotic Microangiopathies | Stem Cell Exhaustion | Third-party mesenchymal stromal cell infusion is associated with a decrease in thrombotic microangiopathy symptoms observed post-hematopoietic stem cell transplantation. | 22151234 |
| Tumor necrosis, Pulmonary Dysfunction | Stem Cell Exhaustion | Soluble tumor necrosis factor receptor: enbrel (etanercept) for subacute pulmonary dysfunction following allogeneic stem cell transplantation. | 22155140 |
| physiopathological, Lung diseases | Stem Cell Exhaustion | Subacute lung disease, manifested as either obstructive (OLD) or restrictive (RLD) lung dysfunction, is a common complication following allogeneic stem cell transplantation. | 22155140 |
| Lung Injury | Stem Cell Exhaustion | These data support the development of expanded clinical trials to study etanercept as a therapeutic agent for subacute lung injury after allogeneic stem cell transplantation. | 22155140 |
| Neoplasms | Stem Cell Exhaustion | Disruption of Klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice. | 22155367 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Autologous stem cell transplantation (ASCT) prolongs survival in patients with relapsed follicular lymphoma. | 22155507 |
| Osteoarthritis, Knee | Stem Cell Exhaustion | Synovial fluid CD34- CD44+ CD90+ mesenchymal stem cell levels are associated with the severity of primary knee osteoarthritis. | 22155731 |
| Osteoarthritis, Knee | Stem Cell Exhaustion | To the best of our knowledge, no reports have directly compared synovial fluid (SF)- and synovial membrane (SM)-derived mesenchymal stem cells (MSCs) from primary knee osteoarthritis patients in terms of MSC proportion, either immediately after isolation or during culture. | 22155731 |
| Glioblastoma Multiforme Pathway, Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | We then investigated the MARK4L and MARK4S expression profile in 21 glioma cell lines and 36 tissues of different malignancy grades, glioblastoma-derived cancer stem cells (GBM CSCs) and mouse neural stem cells (NSCs) by real-time PCR, immunoblotting and immunohistochemistry. | 22156016 |
| Encephalomyelitis, MS gene | Stem Cell Exhaustion | Catastrophic demyelinating encephalomyelitis after intrathecal and intravenous stem cell transplantation in a patient with multiple sclerosis. | 22156784 |
| MS gene | Stem Cell Exhaustion | Stem cell transplantation is an investigational therapy for multiple sclerosis. | 22156784 |
| Encephalomyelitis | Stem Cell Exhaustion | The authors describe a case of catastrophic demyelinating encephalomyelitis following stem cell transplantation in a 17-year-old girl. | 22156784 |
| MS gene | Stem Cell Exhaustion | Nine months after an initial diagnosis of multiple sclerosis, she underwent stem cell transplantation in Costa Rica. | 22156784 |
| Encephalomyelitis, MS gene | Stem Cell Exhaustion | This case demonstrates that stem cell transplantation may provoke life-threatening encephalomyelitis in patients with multiple sclerosis. | 22156784 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | Influence of oral health on mucositis in patients undergoing hematopoietic progenitor cell transplantation (HPCT). | 22157660 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | To establish whether or not the state of patient oral health can influence the occurrence and/or severity of oral mucositis during hematopoietic progenitor cell transplantation (HPCT). | 22157660 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | This new approach will expand our possibilities to separate CML and normal stem cells, present in a single bone marrow or peripheral blood sample, thereby offering opportunities to better identify new CML stem-cell-specific targets. | 22157734 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Residual normal stem cells can be detected in newly diagnosed chronic myeloid leukemia patients by a new flow cytometric approach and predict for optimal response to imatinib. | 22157734 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Insensitivity of chronic myeloid leukemia (CML) hematopoietic stem cells to tyrosine kinase inhibitors (TKIs) prevents eradication of the disease and may be involved in clinical resistance. | 22157734 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | For improved treatment results more knowledge about CML stem cells is needed. | 22157734 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | We here present a new flow cytometric approach enabling prospective discrimination of CML stem cells from their normal counterparts within single-patient samples. | 22157734 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | In 24 of 40 newly diagnosed CML patients residual normal CD34(+)CD38(-) stem cells could be identified by lower CD34 and CD45 expression, lower forward/sideward light scatter and by differences of lineage marker expression (CD7, CD11b and CD56) and of CD90. | 22157734 |
| Toxic effect | Stem Cell Exhaustion | Patients with residual non-leukemic stem cells had lower clinical risk scores (Sokal, Euro), lower hematological toxicity of imatinib (IM) and better molecular responses to IM than patients without. | 22157734 |
| Secondary to, Myeloma cell | Stem Cell Exhaustion | Secondary MGUS after autologous hematopoietic progenitor cell transplantation in plasma cell myeloma: a matter of undetermined significance. | 22158387 |
| Myeloma cell | Stem Cell Exhaustion | Plasma cell myeloma, characterized by clonally aberrant plasma cells that produce abnormal monoclonal Igs, is the most common indication for autologous hematopoietic progenitor cell transplantation (AHPCT) in North America. | 22158387 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Myelodysplastic syndromes (MDS) are hematopoietic stem cell disorders that often progress to chemotherapy-resistant secondary acute myeloid leukemia (sAML). | 22158538 |
| Degenerative polyarthritis, Osteoporosis | Stem Cell Exhaustion | Differential responsiveness to 17b-estradiol of mesenchymal stem cells from postmenopausal women between osteoporosis and osteoarthritis. | 22159632 |
| Degenerative polyarthritis, Osteoporosis | Stem Cell Exhaustion | Differential osteogenic potential and responsiveness to 17b-estradiol (E2) of mesenchymal stem cells (MSCs) were found between postmenopausal women with osteoporosis (OP) and osteoarthritis (OA). | 22159632 |
| Recurrent Primary Malignant Neoplasm, Multiple Myeloma | Stem Cell Exhaustion | What is the benefit of maintenance therapy with lenalidomide or bortezomib after autologous stem cell transplantation in multiple myeloma and what is the risk of developing a secondary primary malignancy? | 22160035 |
| Coronary Arteriosclerosis, diabetic | Stem Cell Exhaustion | Coronary arterial disease (CAD) is common in diabetic patients, and endothelial progenitor cells (EPCs) are considered a surrogate marker for CAD, but controversies regarding this issue still remain. | 22160247 |
| Multiple Myeloma | Stem Cell Exhaustion | Administration of bortezomib before and after autologous stem cell transplantation improves outcome in multiple myeloma patients with deletion 17p. | 22160383 |
| Neoplasms, Childhood Breast Carcinoma | Stem Cell Exhaustion | Incremental increase in VEGFR1+ hematopoietic progenitor cells and VEGFR2+ endothelial progenitor cells predicts relapse and lack of tumor response in breast cancer patients. | 22160642 |
| Specialty Type - cancer | Stem Cell Exhaustion | Four of 14 studied genes, epidermal growth factor receptor (EGFR), Collagen a-1(I) chain, Mast/stem cell growth factor receptor (KIT) and CD47, exhibited significant differences in gene expression between controls and cancer patients. | 22160796 |
| HMOX1 gene, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The stem cell-enriched CD34+/CD38+ and CD34+/CD38- fractions of AML cells were found to express Hsp32 mRNA in excess over normal CD34+ progenitor cells. | 22165967 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Finally, we were able to demonstrate that SMA-ZnPP inhibits cytokine-dependent proliferation of CD34+/CD38+ and CD34+/CD38- AML progenitor cells in vitro in all patients as well as leukemiainitiation of AML stem cells in NOD-SCID IL-2Rg(-/-) (NSG) mice in vivo. | 22165967 |
| HMOX1 gene, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Together, our data suggest that Hsp32 plays an important role as a survival factor in leukemic stem cells and as a potential new target in AML. | 22165967 |
| HMOX1 gene | Stem Cell Exhaustion | The Hsp32 inhibitors SMA-ZnPP and PEG-ZnPP exert major growth-inhibitory effects on D34+/CD38+ and CD34+/CD38- AML progenitor cells. | 22165967 |
| Klinefelter Syndrome | Stem Cell Exhaustion | Can pubertal boys with Klinefelter syndrome benefit from spermatogonial stem cell banking? | 22166807 |
| Klinefelter Syndrome, Infertility | Stem Cell Exhaustion | Although early development of testes appears normal in boys with Klinefelter syndrome (KS), spermatogonial stem cell (SSC) depletion occurs in mid puberty, leading to infertility. | 22166807 |
| Stem cells | Stem Cell Exhaustion | Cryopreservation of SSCs prior to stem cell loss is an option that is currently offered to boys who have to undergo gonadotoxic treatments. | 22166807 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Treatment, risk factors, and outcome of adults with relapsed AML after reduced intensity conditioning for allogeneic stem cell transplantation. | 22167752 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Because information on management and outcome of AML relapse after allogeneic hematopoietic stem cell transplantation (HSCT) with reduced intensity conditioning (RIC) is scarce, a retrospective registry study was performed by the Acute Leukemia Working Party of EBMT. | 22167752 |
| Malignant tumor of colon, Carcinogenesis | Stem Cell Exhaustion | The transcription factor SOX2, which is involved in the induction of pluripotent stem cells and contributes to colorectal carcinogenesis, is associated with a poor prognosis in colon cancer (CC). | 22168803 |
| Malignant Neoplasms, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Chronic myeloid leukemia (CML) is a malignant clonal disease derived from hematopoietic stem cells. | 22169287 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | CML stem cells were thought to be the root which could lead disease development and ultimately rapid change. | 22169287 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | However, a stable animal model for studying the characteristics of CML stem cells is currently lacking. | 22169287 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | This study was aimed to establish a transplanted human CML nude-mice model to further explore the biological behavior of CML stem cells in vivo, and to enrich CML stem cells in nude mice by series transplantation. | 22169287 |
| Bacteremia, Infection | Stem Cell Exhaustion | Patients receiving high-dose chemotherapy with autologous peripheral blood stem cell transplantation (PBSCT) are at high risk of infections, especially bacteraemia. | 22169408 |
| Lymphoproliferative Disorders | Stem Cell Exhaustion | Epstein-Barr virus-associated post-transplant lymphoproliferative disorders after allogeneic peripheral blood stem cell transplantation for Hodgkin-like adult T-cell leukemia/lymphoma. | 22170229 |
| Hodgkin-Like Adult T-Cell Leukemia/Lymphoma | Stem Cell Exhaustion | A 56-year-old woman with Hodgkin-like adult T-cell leukemia/lymphoma was treated with allogeneic peripheral blood stem cell transplantation on 17 April 2009. | 22170229 |
| SERPINB3 wt Allele, Specialty Type - cancer, Malignant Neoplasms, Squamous cell carcinoma | Stem Cell Exhaustion | Although the stem cell markers of original normal tissue have been used to identify cancer stem cells in a variety of cancers, the expression and function of p75NTR have been poorly understood in oral squamous cell carcinoma (OSCC). | 22170235 |
| Inflammation | Stem Cell Exhaustion | Regenerative potential of human muscle stem cells in chronic inflammation. | 22171690 |
| Inflammation | Stem Cell Exhaustion | Chronic inflammation is a profound systemic modification of the cellular microenvironment which could affect survival, repair and maintenance of muscle stem cells. | 22171690 |
| Inflammation, Hepatobiliary Disorder | Stem Cell Exhaustion | TLR4-positive hepatic progenitor cells and interlobular bile ducts were significantly correlated with the stage of liver disease (P<0.001), the grade of inflammation (P<0.001), and the activity of portal/septal myofibroblasts (P<0.001). | 22173288 |
| Liver damage | Stem Cell Exhaustion | The present results suggest that TLR4 expression by hepatic progenitor cells and biliary epithelial cells contributes to the progression of liver damage in the course of chronic HCV-related infection. | 22173288 |
| Ischemia | Stem Cell Exhaustion | Acute ischaemia or other stressors induce the mobilization of progenitor cells from the BM stem cell niche. | 22173911 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Acute myocardial infarction activates progenitor cells and increases Wnt signalling in the bone marrow. | 22173911 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Acute myocardial infarction is associated with an increased metabolic activity and increased levels of progenitor cells within days after AMI. | 22173911 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | In contrast to the other stem cell associated antigens analyzed (CD34, CD96, CD117, and CD133), hMICL was expressed on myeloid blast cells only, revealing hMICL as a diagnostic marker in AML. | 22173921 |
| Disorder of eye, Specialty Type - cancer, HIV, Acquired Immunodeficiency Syndrome | Stem Cell Exhaustion | Stem cell therapies are currently being applied to over 50 diseases, including heart, lung, neurodegenerative, and eye disease, cancer, and human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS). | 22175514 |
| Prostate carcinoma, Spinal Cord Injuries | Stem Cell Exhaustion | Some high-profile therapies include Dendreon's Provenge for prostate cancer, Geron's first-ever embryonic stem cell trials for spinal cord injury, Fibrocell's laViv cellular therapy for wrinkles, and well-established commercial skin substitutes (Organogenesis' Apligraf and Advanced BioHealing's Dermagraft). | 22175514 |
| Neurodegenerative Disorders | Stem Cell Exhaustion | Contemporary stem cell science advances include a focus on techniques for the direct reprogramming of cells from one lineage to another without returning to pluripotency as an intermediary step, improved means of generating and characterizing induced pluripotent cells, and progress in approaches to neurodegenerative disease. | 22175514 |
| Toxic effect | Stem Cell Exhaustion | Stem cells are useful not only in cell-replacement therapies, but also in disease modeling, drug discovery, and drug toxicity screening. | 22175514 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | The pathological characteristics of glioma stem cell niches. | 22178090 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | We demonstrate that both CD133(+) blood vessels and nestin(+) blood vessels have an important role in maintaining the structure of the glioma stem cell niche. | 22178090 |
| Neoplasms | Stem Cell Exhaustion | Brain tumor stem cells (BTSC) are predicted to be critical drivers of tumor progression due to their self-renewal capacity and limitless proliferative potential. | 22178090 |
| Seizures | Stem Cell Exhaustion | High white blood cell concentration in the peripheral blood stem cell product can induce seizures during infusion of autologous peripheral blood stem cells. | 22178402 |
| Seizures | Stem Cell Exhaustion | Seizures as a complication of the infusion of autologous peripheral blood stem cells (PBSC) are rare. | 22178402 |
| Liver carcinoma, Liver Dysfunction | Stem Cell Exhaustion | Are autologous bone marrow stem cell transplantation and transcatheter arterial embolization the best choices for patients with hepatocellular carcinoma and hepatic dysfunction? | 22179797 |
| Liver carcinoma, Liver Dysfunction, Hollings Cancer Center | Stem Cell Exhaustion | The purpose of this work was to evaluate the effects of autologous bone marrow stem cell transplantation (AMSCT) and transarterial embolization (TAE) in patients with hepatocellular carcinoma (HCC) and hepatic dysfunction. | 22179797 |
| Hollings Cancer Center, Neoplasms | Stem Cell Exhaustion | A 58-year-old male with HCC and hepatic function of Child's class C was treated with 8 ml of a lipiodol emulsion by injection into the artery feeding of his tumor, and >10(8) bone marrow stem cells were isolated from 400 ml bone marrow and then injected into the right hepatic artery. | 22179797 |
| Central neuroblastoma, niobium | Stem Cell Exhaustion | Little is known on strategies to prevent or to treat relapses occurring after haploidentical stem cell transplantation (haplo-HSCT) performed for the high-risk neuroblastoma (NB). | 22180305 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Additionally, an immunological mechanism modified by interferon-a might control chronic myeloid leukemia stem cells. | 22180435 |
| Diabetes, Ischemia | Stem Cell Exhaustion | Currently undergoing investigation are adipose stem cell (ASC) therapies for diabetes and critical limb ischemia, among others. | 22185824 |
| Graft-vs-Host Disease, Sinusitis | Stem Cell Exhaustion | Immunosuppression is the leading cause of recurrent sinus infections after hematopoietic stem cell transplant (HSCT), with increased incidence of sinusitis in patients with chronic graft versus host disease (GVHD). | 22186237 |
| Infection of bloodstream | Stem Cell Exhaustion | Mortality after bloodstream infections in allogeneic haematopoietic stem cell transplant (HSCT) recipients. | 22187340 |
| Behavioral Symptoms Index Composite Score (BASC-2), Infection of bloodstream | Stem Cell Exhaustion | Bloodstream infections (BSIs) are frequent after allogeneic haematopoietic stem cell transplantation (HSCT). | 22187340 |
| Hematologic Neoplasms | Stem Cell Exhaustion | The records of the Infection Control Committee were reviewed to identify patients with haematological malignancies and stem cell transplantation who had at least 1 BDG (Fungitell kit) measurement during the period January 2008 through April 2011. | 22188426 |
| Specialty Type - cancer | Stem Cell Exhaustion | In a Cox regression model, stem cell transplant, radiation, and older age at cancer diagnosis were associated with higher hazard of an endocrine condition. | 22188743 |
| Sarcoma - category (morphologic abnormality) | Stem Cell Exhaustion | Radiation, stem cell transplant, and sarcoma diagnosis were associated with growth problems. | 22188743 |
| Malignant melanoma - category | Stem Cell Exhaustion | C-Kit (CD117), the receptor for the stem cell factor, a growth factor for melanocyte migration and proliferation, has shown differential immunostaining in various benign and malignant melanocytic lesions. | 22193299 |
| Thrombocytosis, Thrombocythemia, Essential | Stem Cell Exhaustion | Essential thrombocythemia (ET) is a clonal stem-cell disorder characterized by persistent thrombocytosis. | 22196956 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | An overall increase in the number of AML patients diagnosed nationwide over the last five years indicates a need for additional health care resources including curative and therapy-intense strategies, such as stem cell transplant facilities to optimize outcome. | 22198187 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer survivors often relapse due to evolving drug-resistant clones and repopulating tumor stem cells. | 22198309 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Our preclinical study demonstrated that terminal cancer patient's lymphocytes can be converted from tolerant bystanders in vivo into effective cytotoxic T-lymphocytes in vitro killing patient's own tumor cells containing drug-resistant clones and tumor stem cells. | 22198309 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Lymphodepletion is permissive to the development of spontaneous T-cell responses to the self-antigen PR1 early after allogeneic stem cell transplantation and in patients with acute myeloid leukemia undergoing WT1 peptide vaccination following chemotherapy. | 22198310 |
| Adenocarcinoma, Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | Number of circulating endothelial progenitor cells and intratumoral microvessel density in non-small cell lung cancer patients: differences in angiogenic status between adenocarcinoma histologic subtypes. | 22198428 |
| Malignant neoplasm of lung, Adenocarcinoma | Stem Cell Exhaustion | This study examined the association between the number of circulating endothelial progenitor cells (EPCs), intratumoral microvessel density (MVD) (both of which may be markers for neovascularization), and lung cancer histological types, particularly adenocarcinoma histological subtypes. | 22198428 |
| Multiple Myeloma | Stem Cell Exhaustion | Sequential bortezomib, dexamethasone, and thalidomide maintenance therapy after single autologous peripheral stem cell transplantation in patients with multiple myeloma. | 22198542 |
| Multiple Myeloma | Stem Cell Exhaustion | We report feasibility and response results of a phase II study investigating prolonged weekly bortezomib and dexamethasone followed by thalidomide and dexamethasone as maintenance therapy after single autologous stem cell transplantation (ASCT) in patients with multiple myeloma. | 22198542 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | We studied the outcome of allogeneic hematopoietic stem cell transplantation after lower-intensity conditioning regimens (reduced-intensity conditioning and nonmyeloablative) in patients with non-Hodgkin lymphoma who relapsed after autologous hematopoietic stem cell transplantation. | 22198543 |
| Cerebrovascular accident | Stem Cell Exhaustion | Granulocyte-colony stimulating factor for mobilizing bone marrow stem cells in subacute stroke: the stem cell trial of recovery enhancement after stroke 2 randomized controlled trial. | 22198983 |
| Cerebrovascular accident | Stem Cell Exhaustion | Granulocyte-colony stimulating factor (G-CSF) is neuroprotective in experimental stroke and mobilizes CD34(+) peripheral blood stem cells into the circulation. | 22198983 |
| Non-Small Cell Lung Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | The cancer stem cell antigens CD133, BCRP1/ABCG2 and CD117/c-KIT are not associated with prognosis in resected early-stage non-small cell lung cancer. | 22199321 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | In various tumor entities, expression of cancer stem cell (CSC) antigens has been proven to be prognostically unfavorable. | 22199321 |
| Barrett Esophagus | Stem Cell Exhaustion | Little is known about the stem cell organisation of the normal oesophagus or Barrett's metaplastic oesophagus. | 22200839 |
| Barrett Esophagus, Squamous cell carcinoma of esophagus | Stem Cell Exhaustion | Using non-pathogenic mitochondrial DNA mutations as clonal markers, the authors reveal the stem cell organisation of the human squamous oesophagus and of Barrett's metaplasia and determine the mechanism of clonal expansion of mutations. | 22200839 |
| Barrett Esophagus | Stem Cell Exhaustion | Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor. | 22200839 |
| Barrett Esophagus | Stem Cell Exhaustion | In Barrett's metaplasia partially CCO-deficient glands indicate that glands are maintained by multiple stem cells. | 22200839 |
| Barrett Esophagus | Stem Cell Exhaustion | Wholly mutated Barrett's metaplasia glands containing all the expected differentiated cell lineages were seen, demonstrating multilineage differentiation from a clonal population of Barrett's metaplasia stem cells. | 22200839 |
| Barrett Esophagus | Stem Cell Exhaustion | Barrett's metaplasia glands are clonal units, contain multiple multipotential stem cells and most likely divide by fission. | 22200839 |
| Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | High density of tryptase-positive mast cells in patients with renal cell carcinoma on hemodialysis: correlation with expression of stem cell factor and protease activated receptor-2. | 22204707 |
| Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | The aim of this study was to clarify the pathologic roles of 2 phenotypes of mast cells, mast cell tryptase and mast cell chymase, and their correlation with stem cell factor and protease-activated receptor 2 in patients with renal cell carcinoma on hemodialysis. | 22204707 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | With the use of ChIP on microarray assays in primary leukemia samples, we report that acute myeloid leukemia (AML) blasts exhibit significant alterations in histone H3 acetylation (H3Ac) levels at > 1000 genomic loci compared with CD34(+) progenitor cells. | 22207736 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Importantly, core promoter regions tended to have lower H3Ac levels in AML compared with progenitor cells, which suggested that a large number of genes are epigenetically silenced in AML. | 22207736 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cells (CSCs) are believed to drive tumor progression, but the relative frequencies of CSCs versus non-stem cancer cells span wide ranges even within tumors arising from the same tissue type. | 22208390 |
| Specialty Type - cancer | Stem Cell Exhaustion | Strategies for cancer stem cell elimination: insights from mathematical modeling. | 22210402 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | The cancer stem cell (CSC) hypothesis states that only a small fraction of a malignant cell population is responsible for tumor growth and relapse. | 22210402 |
| S100A4 protein, human | Stem Cell Exhaustion | Further analysis of the same model has indicated that excessive stem cell proliferation leading to malignant transformation mainly results from altered sensitivity to such micro-environmental signals. | 22210402 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Imatinib has revolutionized the treatment for adult CML by eliminating allogeneic stem cell transplantation for almost all patients in chronic phase. | 22210880 |
| Blast Phase | Stem Cell Exhaustion | Patients in accelerated or blast crisis or who fail to reach landmarks on TKIs either because of intolerance or resistance should pursue stem cell transplantation. | 22210880 |
| Malignant Neoplasms | Stem Cell Exhaustion | Expression of deleted in malignant brain tumours 1 (DMBT1) relates to the proliferation and malignant transformation of hepatic progenitor cells in hepatitis B virus-related liver diseases. | 22211283 |
| Inflammation, Endothelium | Stem Cell Exhaustion | Systemic inflammation has been associated with an imbalance between endothelial injury and repair, defined by an increased number of circulating endothelial microparticles (EMPs) and a reduced number of endothelial progenitor cells (EPCs). | 22211720 |
| Hepatitis E | Stem Cell Exhaustion | Chronic hepatitis E in hematopoietic stem cell transplant patients in a low-endemic country? | 22212560 |
| Hepatitis E | Stem Cell Exhaustion | In addition, hepatitis E virus (HEV) reactivation was reported after hematopoietic stem cell transplantation (HSCT). | 22212560 |
| Aortic Valve Stenosis, Cardiovascular Diseases, Atherosclerosis, BDI - Functional Impairment | Stem Cell Exhaustion | Cardiovascular disease has been linked to endothelial progenitor cell (EPC) depletion and functional impairment in atherosclerosis and aortic stenosis. | 22214418 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | Endothelial progenitor cell mobilization and platelet microparticle release are influenced by clopidogrel plasma levels in stable coronary artery disease. | 22214900 |
| Progeria | Stem Cell Exhaustion | Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model. | 22215083 |
| Progeria | Stem Cell Exhaustion | We tested this using muscle-derived stem/progenitor cells (MDSPCs) in a murine progeria model. | 22215083 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | An 8-year-old, human immune virus-negative boy received full human leukocyte antigen-matched related allogenic hematopoietic stem cell transplantation (HSCT) for relapsed acute myeloid leukemia. | 22217492 |
| Neurologic Dysfunction, primary infection nos, Hematopoietic Cell Transplant Recipient, Immunocompromised Host | Stem Cell Exhaustion | The HPyV9 seroprevalence of liver transplant recipients and patients with neurological dysfunctions did not differ from that of age-matched controls, but a significantly higher seroprevalence was determined in renal and haematopoietic stem-cell transplant recipients, indicating that certain immunocompromised patient groups may be at a higher risk for primary infection with or for reactivation of HPyV9. | 22218677 |
| Anemia, Sickle Cell | Stem Cell Exhaustion | Oocyte cryopreservation in a patient with sickle cell disease prior to hematopoietic stem cell transplantation: first report. | 22219083 |
| Anemia, Sickle Cell | Stem Cell Exhaustion | To report the first occurrence of successful ovarian stimulation, oocyte retrieval and oocyte cryopreservation for fertility preservation in an adolescent with severe sickle cell disease scheduled to undergo a hematopoietic stem cell transplant Case report. | 22219083 |
| Anemia, Sickle Cell | Stem Cell Exhaustion | A 19 year old female with severe sickle cell disease presented for fertility preservation counseling prior to hematopoietic stem cell transplantation. | 22219083 |
| Ovarian hyperstimulation, Anemia, Sickle Cell | Stem Cell Exhaustion | Controlled ovarian hyperstimulation and oocyte banking for fertility preservation is feasible in young women with sickle cell disease requiring hematopoietic stem cell transplant and deserves further investigation. | 22219083 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | The role of aldehyde dehydrogenase 1 (ALDH1) as an ovarian cancer stem cell marker and its clinical significance have rarely been explored. | 22222226 |
| Neoplasms, Immunocompromised Host | Stem Cell Exhaustion | Both ALDH1(br) and ALDH1(low) cells repopulated stem cell heterogeneity, formed spheroids, and grew into tumors in immunocompromised mice, although these processes were more efficient in ALDH1(br) cells. | 22222226 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | The results did not support ALDH1 alone as an ovarian cancer stem cell marker, but demonstrated that ALDH1 is associated with CD44 expression, chemoresistance, and poor clinical outcome. | 22222226 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | The use of a combination of ALDH1 with other stem cell markers may help define ovarian cancer stem cells more stringently. | 22222226 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | We used an Aldefluor assay to isolate ALDH1-bright (ALDH1(br)) cells from epithelial ovarian cancer cell lines and characterized the properties of the stem cells. | 22222226 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Bone marrow stem cell adherence into old anterior myocardial infarction: a scintigraphic study using Tl-201 and Tc-99m-HMPAO. | 22222778 |
| Necrosis | Stem Cell Exhaustion | The precise localization of bone marrow stem cells (SCs) into the necrotic tissue after intracoronary infusion (ICI) may be important for the therapeutic outcome. | 22222778 |
| Hematologic Neoplasms, Liver Cirrhosis | Stem Cell Exhaustion | Fourteen patients had a haematologic malignancy, four were transplant recipients (allogeneic haematopoietic stem cells in three, liver in one) and one had hepatic cirrhosis. | 22227384 |
| T-lymphocyte deficiency | Stem Cell Exhaustion | T-cell deficiency after allogeneic stem cell transplantation (ASCT) is common and has major impact on clinical outcome. | 22227522 |
| Myelodysplastic-Myeloproliferative Diseases | Stem Cell Exhaustion | Although poorer collection efficiencies were observed in the myelodysplastic syndrome/myeloproliferative disorder diagnostic subgroup, our findings confirm that PB CD34(+) cell analysis remains a powerful and irreplaceable tool for predicting hematopoietic progenitor cell apheresis CD34(+) cell yield. | 22227589 |
| Multiple Myeloma | Stem Cell Exhaustion | Predictors of prolonged survival after allogeneic hematopoietic stem cell transplantation for multiple myeloma. | 22231283 |
| Multiple Myeloma, Specialty Type - cancer, Morular Metaplasia of the Endometrium | Stem Cell Exhaustion | A total of 149 patients with multiple myeloma (MM) who received allogeneic hematopoietic stem cell transplantation (allo-HCT) with myeloablative (MAC; n = 38) or reduced-intensity conditioning (RIC; n = 110) regimens at MD Anderson Cancer Center were evaluated. | 22231283 |
| Mucopolysaccharidosis I | Stem Cell Exhaustion | It is also generally assumed that cardiovascular risk is increased in MPS and reduced following hematopoietic stem cell transplantation (HSCT) or enzyme replacement therapy (ERT), but this has never been formally evaluated. | 22231383 |
| Malignant tumor of colon, Neoplasms | Stem Cell Exhaustion | Recent studies suggest CD133, a surface protein widely used for isolation of colon cancer stem cells, to be associated with tumor angiogenesis and recurrence. | 22231565 |
| Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | Long-term graft-versus-tumor effect following reduced intensity hematopoietic stem cell transplantation in a child with metastatic renal cell carcinoma. | 22231905 |
| Refractory Cytopenia of Childhood | Stem Cell Exhaustion | Although target agents have recently been introduced, allogeneic hematopoietic stem cell transplantation exploiting graft-versus-tumor effect still remains an important treatment option for metastatic RCC. | 22231905 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | CD27 signaling on chronic myelogenous leukemia stem cells activates Wnt target genes and promotes disease progression. | 22232214 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | In the present study, we investigated the possibility that the TNF receptor family member CD27 is present on leukemia stem cells (LSCs) and mediates effects of the immune system on CML. | 22232214 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Chronic myelogenous leukemia (CML) results from a chromosomal translocation in hematopoietic stem or early progenitor cells that gives rise to the oncogenic BCR/ABL fusion protein. | 22232214 |
| leukemia, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | In a mouse model of CML, BCR/ABL+ LSCs and leukemia progenitor cells were found to express CD27. | 22232214 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Furthermore, CD27 was expressed on CML stem/progenitor cells in the bone marrow of CML patients, and CD27 signaling promoted growth of BCR/ABL+ human leukemia cells by activating the Wnt pathway. | 22232214 |
| Hemolysis (lab result), Aplastic Anemia | Stem Cell Exhaustion | A case of acute hemolytic transfusion reaction caused by anti-AnWj is reported in a patient with aplastic anemia requiring allogeneic stem cell transplantation. | 22233405 |
| Endothelial dysfunction | Stem Cell Exhaustion | Blood endothelial progenitor cells (EPC) and microparticles (EMP) have been proposed as markers of endothelial dysfunction. | 22234180 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Azacitidine augments expansion of regulatory T cells after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML). | 22234690 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Strategies that augment a GVL effect without increasing the risk of GVHD are required to improve the outcome after allogeneic stem cell transplantation (SCT). | 22234690 |
| Neoplasms | Stem Cell Exhaustion | We find that the number of 5 hmC positive cells and the amount of 5 hmC/dG in the genome that has been proposed to be related to pluripotency and lineage commitment in embryonic stem cells is also associated with brain tumor differentiation and anaplasia. | 22234893 |
| Hollings Cancer Center | Stem Cell Exhaustion | As a proof of this concept, a recent study demonstrated a genomic subtype of HCC that expressed CC-like gene expression traits, such as CC-like HCC, which revealed the common genomic trait of stem-cell-like properties and aggressive clinical outcomes. | 22234953 |
| Hollings Cancer Center | Stem Cell Exhaustion | This suggests that S-HCC may harbor common intermediate traits between HCC and CC, including stem-cell traits, which are similar to those of CC-like HCC. | 22234953 |
| Hollings Cancer Center | Stem Cell Exhaustion | Scirrhous HCC (S-HCC), a rare variant of HCC, is characterized by abundant fibrous stroma and has been known to express several liver stem/progenitor cell markers. | 22234953 |
| Squamous cell carcinoma of esophagus | Stem Cell Exhaustion | Prognostic value of the stem cell markers CD133 and ABCG2 expression in esophageal squamous cell carcinoma. | 22236447 |
| Extrapulmonary Small Cell Carcinoma, Specialty Type - cancer, Squamous cell carcinoma of esophagus | Stem Cell Exhaustion | In the light of increasing evidence supporting cancer stem cells (CSCs) theory, the expression of two stem cell markers, CD133 and adenosine triphosphate-binding cassette superfamily G member 2 (ABCG2), in esophageal squamous cell carcinoma (ESCC) was investigated, and their prognostic values were evaluated. | 22236447 |
| Ocular surface disease, Limbal stem cell deficiency | Stem Cell Exhaustion | Retrospective noncomparative case series of 7 eyes in 7 consecutive patients with ocular surface disease and limbal stem cell deficiency treated with KPro after failed KLAL. | 22236785 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Breast cancer cells with CD44+CD24-/low gene expression signature have been suggested to have stem cell-like tumor-initiating properties. | 22237177 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | In addition, either ALDH1 or SOX2 may be a candidate marker for cancer stem cells in luminal subtype breast cancer. | 22237177 |
| Primary Myelofibrosis | Stem Cell Exhaustion | [Stem cell transplantation in myelofibrosis]. | 22238916 |
| Chronic myeloproliferative disorder, Primary Myelofibrosis | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (ASCT) offers the only potentially curative therapy for myelofibrosis, a malignant myeloproliferative disease. | 22238916 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Functional characteristics of mesenchymal stem cells derived from bone marrow of patients with myelodysplastic syndromes. | 22240014 |
| Ischemia | Stem Cell Exhaustion | Arterio-venous gradients of endothelial progenitor cells reveal a complex kinetics in human limb ischemia. | 22240360 |
| Neoplasms, Childhood Breast Carcinoma | Stem Cell Exhaustion | Detection of circulating tumor cells and tumor stem cells in patients with breast cancer by using flow cytometry: a valuable tool for diagnosis and prognosis evaluation. | 22241087 |
| Neoplasms | Stem Cell Exhaustion | Circulating tumor stem cells (CTSC), a subpopulation of circulating tumor cells (CTC), may lead to recurrent diseases. | 22241087 |
| Angioendotheliomatosis | Stem Cell Exhaustion | [Sustained complete remission of intravascular large B-cell lymphoma with recurrent CNS involvement by autologous peripheral blood stem cell transplantation preconditioned with TBC regimen]. | 22241155 |
| Aggressive Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Autologous stem cell transplantation (ASCT) is an effective therapeutic option for refractory or high-risk aggressive lymphoma. | 22241155 |
| Infiltration, Acute lymphocytic leukemia | Stem Cell Exhaustion | [Bilateral renal infiltration of acute lymphoblastic leukemia cells at relapse after allogeneic stem cell transplantation]. | 22241156 |
| Lupus Erythematosus | Stem Cell Exhaustion | [Late results of high-dose immunosuppressive therapy with autotransplantation of hematopoietic stem cells in patients with severe refractory systemic lupus erythematosus]. | 22242267 |
| Lupus Erythematosus, Encephalitis, St. Louis | Stem Cell Exhaustion | The aim of the study was to assess long-term results of high-dose immunosuppressive therapy with autoimplantation of hemopoietic stem cells in patients with severe systemic lupus erythematosus (SLE) resistant to standard immunosuppressive therapy and compare them with the outcome of the two modalities. | 22242267 |
| Lupus Erythematosus | Stem Cell Exhaustion | It is concluded that high-dose immunosuppressive therapy with autoimplantation of hemopoietic stem cells is an efficacious tool for the treatment of lupus erythematosus resistant to standard therapy and has advantages over the latter. | 22242267 |
| Specialty Type - cancer, Malignant neoplasm of stomach, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Expression of cancer stem cell markers ALDH1, CD44 and CD133 in primary tumor and lymph node metastasis of gastric cancer. | 22243781 |
| Specialty Type - cancer, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Recently, cancer stem cells (CSCs) in tumors were found to possess the ability to sustain tumor self-renewal, initiate tumor progression, and possibly also contribute to cancer metastasis. | 22243781 |
| B-Cell Lymphomas | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation in patients with diffuse large B cell lymphoma relapsed after autologous stem cell transplantation: a GITMO study. | 22245922 |
| Parainfluenza Virus Infections, leukemia | Stem Cell Exhaustion | The characteristics and outcomes of parainfluenza virus infections in 200 patients with leukemia or recipients of hematopoietic stem cell transplantation. | 22246027 |
| leukemia | Stem Cell Exhaustion | Community respiratory viruses are significant causes of morbidity and mortality in patients with leukemia and hematopoietic stem cell transplant (HSCT) recipients. | 22246027 |
| PULMONARY VENOOCCLUSIVE DISEASE 1, AUTOSOMAL DOMINANT | Stem Cell Exhaustion | This report is the first to describe PVOD following RIC stem cell transplantation. | 22246490 |
| Colorectal Carcinoma, Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | CD133 has been identified as a putative cancer stem cell (CSC) marker in various cancers including colorectal cancer. | 22246526 |
| Systemic Scleroderma, Sample Size Calculation | Stem Cell Exhaustion | Autologous stem cell transplantation (aSCT) for systemic sclerosis (SSc) has been shown to be effective in recent reports. | 22247352 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Prolonged survival with imatinib mesylate combined with chemotherapy and allogeneic stem cell transplantation in de novo Ph+ acute myeloid leukemia. | 22248505 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | A randomised phase II study of the efficacy, safety and cost-effectiveness of pegfilgrastim and filgrastim after autologous stem cell transplant for lymphoma and myeloma (PALM study). | 22248711 |
| Febrile Neutropenia, Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | To evaluate in a multicentre randomised study the effect on duration of febrile neutropenia (FN), the safety and cost-effectiveness of a single subcutaneous pegfilgrastim injection compared with daily injections of filgrastim after peripheral blood stem cell transplantation in patients receiving high dose chemotherapy for myeloma and lymphoma. | 22248711 |
| Mobilized Peripheral Blood Stem Cell, Multiple Myeloma | Stem Cell Exhaustion | Intermediate-dose versus low-dose cyclophosphamide and granulocyte colony-stimulating factor for peripheral blood stem cell mobilization in patients with multiple myeloma treated with novel induction therapies. | 22248715 |
| Multiple Myeloma | Stem Cell Exhaustion | These data caution against the use of LD-CY-containing mobilization strategies in patients with multiple myeloma undergoing stem cell collection after novel induction regimens. | 22248715 |
| Multiple Myeloma | Stem Cell Exhaustion | Peripheral blood progenitor cell mobilization with intermediate-dose cyclophosphamide (ID-CY) and granulocyte colony-stimulating factor (G-CSF) has been shown to be more efficacious, albeit more toxic, than low-dose cyclophosphamide (LD-CY) mobilization regimens in patients with multiple myeloma treated with conventional therapies. | 22248715 |
| Failure | Stem Cell Exhaustion | In conclusion, compared with LD-CY, ID-CY produced a more robust peripheral blood progenitor cell mobilization and significantly reduced the rates of mobilization failure. | 22248715 |
| Toxoplasmosis | Stem Cell Exhaustion | Toxoplasmosis after allogeneic stem cell transplantation--a single centre experience. | 22249208 |
| Toxoplasmosis | Stem Cell Exhaustion | Toxoplasmosis is a rare but possibly underestimated complication following allogeneic stem cell transplantation with a high mortality rate. | 22249208 |
| Personality Character, PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Myelodysplastic syndrome (MDS), a clonal disorder originating from hematopoietic stem cell, is characterized by a progressive character often leading to transformation to acute myeloid leukemia. | 22250017 |
| Specialty Type - cancer, Neoplasms, Carcinogenesis | Stem Cell Exhaustion | Because of some inconsistencies in the traditional model of human colorectal carcinogenesis, the cancer stem cell (CSC) model was recently proposed, in which tumor results from neoplastic transformation of stem cells, which become CSCs. | 22250106 |
| Aggressive Non-Hodgkin Lymphoma | Stem Cell Exhaustion | A randomized study comparing yttrium-90 ibritumomab tiuxetan (Zevalin) and high-dose BEAM chemotherapy versus BEAM alone as the conditioning regimen before autologous stem cell transplantation in patients with aggressive lymphoma. | 22252613 |
| Aggressive Non-Hodgkin Lymphoma | Stem Cell Exhaustion | High-dose chemotherapy combined with autologous stem-cell transplantation (ASCT) is the standard therapy for refractory/relapsed aggressive lymphoma. | 22252613 |
| Loneliness | Stem Cell Exhaustion | Social correlates of distress following hematopoietic stem cell transplantation: exploring the role of loneliness and cognitive processing. | 22253329 |
| Specialty Type - cancer | Stem Cell Exhaustion | Participants were 195 cancer survivors who had undergone hematopoietic stem cell transplantation. | 22253329 |
| Vascular Diseases, Systemic Scleroderma, Sample Size Calculation | Stem Cell Exhaustion | It has been proposed that dysfunctional endothelial progenitor cells (EPCs) play a role in pathogenic vasculopathy in systemic sclerosis (SSc). | 22258488 |
| Non-Cancer Related Death, Specialty Type - cancer | Stem Cell Exhaustion | This study provides further evidence for the stem cell character of ALDH1+ cells, here in benign breast tissue of cancer and non-cancer patients throughout non-lactating adult life, and contributes evidence of benign stromal ALDH1+ cells. | 22260461 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Distribution of aldehyde dehydrogenase 1-positive stem cells in benign mammary tissue from women with and without breast cancer. | 22260461 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Relapse of acute myeloid leukemia (AML) is thought to reflect the failure of current therapies to adequately target leukemia stem cells (LSCs), the rare, resistant cells presumed responsible for maintenance of the leukemia and typically enriched in the CD34(+)CD38(-) cell population. | 22262762 |
| Diabetes Mellitus | Stem Cell Exhaustion | We tested the hypothesis that new-onset posttransplantation diabetes mellitus (PTDM) is associated with measurable changes in Treg subsets after allogeneic hematopoietic stem cell transplantation (HSCT). | 22262764 |
| Neoplasms, Primary malignant neoplasm | Stem Cell Exhaustion | Expression of stem cell and epithelial-mesenchymal transition markers in primary breast cancer patients with circulating tumor cells. | 22264265 |
| Neoplasms, Childhood Breast Carcinoma, Primary Neoplasm | Stem Cell Exhaustion | The presence of circulating tumor cells (CTC) in breast cancer might be associated with stem cell-like tumor cells which have been suggested to be the active source of metastatic spread in primary tumors. | 22264265 |
| Primary malignant neoplasm | Stem Cell Exhaustion | We studied the expression of three EMT markers and the stem cell marker ALDH1 in CTC from 502 primary breast cancer patients. | 22264265 |
| Neoplasms | Stem Cell Exhaustion | The recovered c-DNA was additionally multiplex tested for three EMT markers [TWIST1, Akt2, phosphoinositide kinase-3 (PI3Ka)] and separately for the tumor stem cell marker ALDH1. | 22264265 |
| Primary malignant neoplasm | Stem Cell Exhaustion | Our data indicate that (1) a subset of primary breast cancer patients shows EMT and stem cell characteristics and (2) the currently used detection methods for CTC are not efficient to identify a subtype of CTC which underwent EMT. | 22264265 |
| Neoplasms | Stem Cell Exhaustion | We previously identified a population of CD133+ brain tumor cells possessing stem cell properties, known as brain tumor initiating cells (BTICs). | 22265735 |
| Neoplasms | Stem Cell Exhaustion | Bmi1 expression profiles show a marked elevation in the proneural GBM subtype, and stem cell frequency as assessed by tumor sphere assays correlates with patient outcome. | 22265735 |
| Neoplasms, Colorectal Carcinoma, Specialty Type - cancer, Cytogenetic Complete Response | Stem Cell Exhaustion | The clinical significance of circulating tumor cells (CTCs) including cancer stem cells (CSCs) (CTC/CSC) in the tumor drainage vein blood of patients with colorectal cancer (CRC) is unclear. | 22267181 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | Failure of pre-emptive treatment of cytomegalovirus infections and antiviral resistance in stem cell transplant recipients. | 22267468 |
| Infection | Stem Cell Exhaustion | Treatment of cytomegalovirus (CMV) infections after stem cell transplantation (SCT) does not always lead to a rapid viral response. | 22267468 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Consolidative therapy with stem cell transplantation improves survival of patients with mantle cell lymphoma after any induction regimen. | 22269117 |
| Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | Stem Cell Exhaustion | Intensive induction regimen followed by high-dose chemotherapy and autologous stem cell transplantation (auto-SCT) is frequently used to improve outcomes in patients with mantle-cell lymphoma. | 22269117 |
| Bone necrosis | Stem Cell Exhaustion | However, there have been no long-term follow-up studies on humans treated with adipose tissue-derived stem cells for osteonecrosis. | 22270740 |
| Hip joint pain, Avascular Necrosis of Femur Head | Stem Cell Exhaustion | To determine if treatment with adipose tissue-derived stem cells and platelet-rich plasma leads to the regeneration of medullary bone-like tissue and long-term reduction of hip pain in patients with femoral head osteonecrosis. | 22270740 |
| Hip joint pain, Avascular Necrosis of Femur Head | Stem Cell Exhaustion | Two patients (34- and 39-year-old men) with femoral head osteonecrosis and severe hip pain were treated with adipose-derived stem cells. | 22270740 |
| Ischemic cardiomyopathy | Stem Cell Exhaustion | Effect of 40 mg versus 10 mg of atorvastatin on oxidized low-density lipoprotein, high-sensitivity C-reactive protein, circulating endothelial-derived microparticles, and endothelial progenitor cells in patients with ischemic cardiomyopathy. | 22271072 |
| Ischemic cardiomyopathy, between breakfast and lunch | Stem Cell Exhaustion | There are few recent data to delineate the beyond lipids-decreased effect of statins and the effect of different doses of statins on endothelial-derived microparticles (EMPs) and circulating endothelial progenitor cells (EPCs) in patients with ischemic cardiomyopathy (ICM). | 22271072 |
| Hodgkin Disease | Stem Cell Exhaustion | Positron emission tomography response at the time of autologous stem cell transplantation predicts outcome of patients with relapsed and/or refractory Hodgkin's lymphoma responding to prior salvage therapy. | 22271893 |
| Hodgkin Disease | Stem Cell Exhaustion | High-dose chemotherapy followed by autologous stem cell transplantation is the standard treatment for relapsed and/or refractory Hodgkin's lymphoma although half of patients relapse after transplantation. | 22271893 |
| Hodgkin Disease | Stem Cell Exhaustion | The aim of this study was to confirm the predictive value of positron emission tomography status after salvage therapy and to compare single versus tandem autologous stem cell transplantation in patients with relapsed and/or refractory Hodgkin's lymphoma. | 22271893 |
| Hodgkin Disease | Stem Cell Exhaustion | We report a series of 111 consecutive patients with treatment-sensitive relapsed and/or treatment-refractory Hodgkin's lymphoma who achieved complete (positron emission tomography-negative group) or partial remission (positron emission tomography-positive group) at positron emission tomography evaluation after salvage chemotherapy and who underwent single or tandem autologous stem cell transplantation. | 22271893 |
| Hodgkin Disease | Stem Cell Exhaustion | In patients with relapsed/refractory Hodgkin's lymphoma responding to prior salvage therapy, positron emission tomography response at time of autologous stem cell transplantation favorably influences outcome and enables identification of patients requiring single or tandem transplantation. | 22271893 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | In this validation study, we refined the standard operating procedure (SOP) for flow cytometry characterisation and functional analysis of CPCs from the first 18 patients of the Progenitor Cell Response after Myocardial Infarction Study (ProMIS). | 22272341 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Stepwise optimization of the procedure for assessment of circulating progenitor cells in patients with myocardial infarction. | 22272341 |
| diabetic | Stem Cell Exhaustion | The number and functional activity of circulating progenitor cells (CPCs) is altered in diabetic patients. | 22272341 |
| Pneumocystis jiroveci pneumonia | Stem Cell Exhaustion | Pneumocystis jirovecii pneumonia (PJP) was found in four patients (3%, 4/122) receiving alemtuzumab as conditioning for stem cell transplant or salvage treatment. | 22273250 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | In this report, we describe the experience of a 53-year-old woman who is the sole caregiver for her husband, who has acute myelogenous leukemia and was undergoing allogeneic hematopoietic stem cell transplantation. | 22274687 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Senescent cells in growing tumors: population dynamics and cancer stem cells. | 22275856 |
| Specialty Type - cancer | Stem Cell Exhaustion | In the hierarchical cancer model a subset of the cells, the cancer stem cells, divide indefinitely while other cells eventually turn senescent. | 22275856 |
| Specialty Type - cancer | Stem Cell Exhaustion | We conclude that enhancing senescence is unlikely to provide a useful therapeutic strategy to fight cancer, unless the cancer stem cells are specifically targeted. | 22275856 |
| Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | High expression of CD133 and b-catenin, both related to cancer stem cell phenotypes, might be predictive markers for metastasis. | 22276605 |
| Cerebral Infarction | Stem Cell Exhaustion | Neuronal stem cells are mobilized after cerebral infarction. | 22277485 |
| Cerebrovascular accident | Stem Cell Exhaustion | We had shown that appropriate support of these stem cells, achieved by therapeutic angiogenesis, enhances neurological recovery in experimental stroke model. | 22277485 |
| Neurologic Symptoms, Amyloidosis | Stem Cell Exhaustion | High-dose melphalan with stem cell transplantation improves prognosis of systemic AL amyloidosis including neurological symptoms. | 22277508 |
| Alzheimers Disease | Stem Cell Exhaustion | Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. | 22278060 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | Age determines the prognostic role of the cancer stem cell marker aldehyde dehydrogenase-1 in breast cancer. | 22280212 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | The purpose of this study was to compare the expression and the prognostic effect of the breast cancer stem cell marker aldehyde dehydrogenase-1 (ALDH1) in young and elderly breast cancer patients. | 22280212 |
| Primary Myelofibrosis | Stem Cell Exhaustion | To define a prognostic model for predicting outcome of reduced-intensity allogeneic stem cell transplantation (RIC-ASCT) for myelofibrosis we evaluated 150 homogeneously treated patients and developed a new risk score for overall survival (OS). | 22280409 |
| Idiopathic Pulmonary Fibrosis | Stem Cell Exhaustion | Because most fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF), are associated with vascular remodeling, and as endothelial progenitor cells (EPCs) may be involved in this process, we investigated the impact of TGF-b1 modulation of EPC angiogenic properties. | 22284809 |
| Ischemia, Diabetic Foot, Ulcer | Stem Cell Exhaustion | Autologous stem cell therapy in the treatment of limb ischaemia induced chronic tissue ulcers of diabetic foot patients. | 22284892 |
| Autoimmune hemolytic anemia | Stem Cell Exhaustion | Livedo reticularis associated with autoimmune hemolytic anemia: prolonged remission induced by peripheral blood stem cell transplantation relapse after 10 years and restoration of hemoglobin levels by rituximab. | 22286652 |
| Peripheral Stem Cell Transplantation | Stem Cell Exhaustion | It is described and discussed a case of livedo reticularis associated with AIHA treated with peripheral blood stem cell transplantation (PBSCT) that went into full remission for 10 years. | 22286652 |
| vasculogenesis | Stem Cell Exhaustion | Neovasculogenesis induced by stem cell therapy could be a useful approach for these patients. | 22289660 |
| melanoma, Specialty Type - cancer | Stem Cell Exhaustion | Regression of metastatic melanoma in a patient by antibody targeting of cancer stem cells. | 22289880 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | Safety and efficacy of total body irradiation, cyclophosphamide, and cytarabine as a conditioning regimen for allogeneic hematopoietic stem cell transplantation in patients with acute lymphoblastic leukemia. | 22290459 |
| Acute lymphocytic leukemia, BCR gene | Stem Cell Exhaustion | Disease relapse still greatly interferes with the success of allogeneic hematopoietic stem cell transplantation (HSCT) for acute lymphoblastic leukemia (ALL). | 22290459 |
| Diabetes Mellitus | Stem Cell Exhaustion | The possible role of ribosomal protein S6 kinase 4 in the senescence of endothelial progenitor cells in diabetes mellitus. | 22297070 |
| Hyperglycemia, Dominica, Diabetes Mellitus | Stem Cell Exhaustion | The decrease and dysfunction of endothelial progenitor cells (EPCs) has been assumed as an important cause/consequence of diabetes mellitus (DM) and its complications, in which the senescence of EPCs induced by hyperglycemia may play an immensurable role. | 22297070 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | Endothelial progenitor cells are associated with plasma homocysteine in coronary artery disease. | 22299389 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | Little is known about the association between plasma homocysteine (Hcy) and endothelial progenitor cells (EPCs) in coronary artery disease (CAD). | 22299389 |
| Blastic plasmacytoid dendritic cell neoplasm, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We report a 15-year-old boy with blastic plasmacytoid dendritic cell neoplasm who was treated with acute myeloid leukemia-based polychemotherapy and subsequent allogenic stem cell transplantation. | 22300352 |
| PMF Regimen | Stem Cell Exhaustion | In this study we evaluated the apoptosis-related gene and protein expression of BCL2 family members in bone marrow CD34+ hematopoietic stem cells (HSC) and peripheral blood leukocytes from ET and PMF patients. | 22300941 |
| Neoplasms | Stem Cell Exhaustion | Expression of the stem cell marker octamer 4 (Oct-4) in various neoplasms has been previously reported, but very little is currently known about the potential function of Oct-4 in this setting. | 22300949 |
| Multiple Myeloma | Stem Cell Exhaustion | Bioactivity and prognostic significance of growth differentiation factor GDF15 secreted by bone marrow mesenchymal stem cells in multiple myeloma. | 22301101 |
| Multiple Myeloma | Stem Cell Exhaustion | Overexpression of growth differentiation factor 15 (GDF15) by bone marrow mesenchymal stem cells occurs widely in patients with multiple myeloma, but the pathophysiologic effects of GDF15 in this setting remain undefined. | 22301101 |
| Olivopontocerebellar Atrophies | Stem Cell Exhaustion | Generation of induced pluripotent stem cells from skin fibroblasts of a patient with olivopontocerebellar atrophy. | 22301348 |
| Axonal neuropathy | Stem Cell Exhaustion | Application of autologous bone marrow stem cells in giant axonal neuropathy. | 22301809 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Prognostic factors in patients aged 50 years or older undergoing allogeneic hematopoietic stem cell transplantation for hematologic malignancy. | 22302471 |
| Hematologic Neoplasms | Stem Cell Exhaustion | We retrospectively analyzed patients aged C 50 years with hematologic malignancies who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) to identify preoperative variables predicting the outcome. | 22302471 |
| Fibrosis Assessment | Stem Cell Exhaustion | Activin-A is a molecule of the TGF superfamily, implicated in liver fibrosis, regeneration and stem cell differentiation. | 22304651 |
| Bronchiolitis Obliterans | Stem Cell Exhaustion | Altered progenitor cell and cytokine profiles in bronchiolitis obliterans syndrome. | 22305385 |
| Lung Injury, Fibrosis Assessment | Stem Cell Exhaustion | The contribution of CD45(+)collagen-1(+) fibrocytes to fibrosis has been documented elsewhere and recently identified epithelial-like progenitor cells marked by Clara cell secretory protein (CCSP(+)) may be protective after lung injury. | 22305385 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Long-term survival after high-dose chemotherapy followed by peripheral stem cell rescue for high-risk, locally advanced/inflammatory, and metastatic breast cancer. | 22306735 |
| Degenerative disorder | Stem Cell Exhaustion | The generation of induced pluripotent stem cells (iPSCs) from differentiated somatic cells by over-expression of several transcription factors has the potential to cure many genetic and degenerative diseases currently recalcitrant to traditional clinical approaches. | 22310243 |
| Malignant Neoplasms | Stem Cell Exhaustion | Dose-adjusted EPOCH-rituximab combined with fludarabine provides an effective bridge to reduced-intensity allogeneic hematopoietic stem-cell transplantation in patients with lymphoid malignancies. | 22312100 |
| Malignant Neoplasms | Stem Cell Exhaustion | There is currently no standard chemotherapy regimen for patients with lymphoid malignancies being considered for reduced-intensity conditioning allogeneic hematopoietic stem-cell transplantation (RIC-alloHSCT). | 22312100 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Direct transplantation of mesenchymal stem cells into the knee joints of Hartley strain guinea pigs with spontaneous osteoarthritis. | 22314040 |
| Degenerative polyarthritis | Stem Cell Exhaustion | The aim of this study was to test the outcome of intra-articular transplantation of mesenchymal stem cells suspended in hyaluronic acid (HA) in the knee joints of Hartley strain guinea pigs with spontaneous osteoarthritis (OA). | 22314040 |
| Neoplasms, Carcinoma | Stem Cell Exhaustion | In the present study we have investigated the morphologic features, the CpG methylator phenotype (CIMP), microsatellite instability (MSI), and the immunohistochemical profile, including the expression of transcription factors (TTF1, ASH1, CDX2, and PAX5), stem cell markers (CD117 and CD34), and cytokeratins 7 and 20, in a series of 39 carcinomas (27 NECs and 12 MANECs) to better characterize such neoplasms and to search for prognostic indicators. | 22314183 |
| Neoplasms | Stem Cell Exhaustion | In addition to these prognostic features, neoplasms showed different expression of transcription factors, stem cell markers, and cytokeratins that should be considered for diagnostic purposes and, especially, for discriminating among possible differential diagnoses. | 22314183 |
| Paroxysmal nocturnal hemoglobinuria, Glycosylphosphatidylinositols | Stem Cell Exhaustion | Patients with paroxysmal nocturnal hemoglobinuria harbor clonal glycosylphosphatidylinositol-anchor deficient cells arising from a multipotent hematopoietic stem cell acquiring a PIG-A mutation. | 22315493 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cells. | 22315493 |
| Paroxysmal nocturnal hemoglobinuria, Aplastic Anemia, MYELODYSPLASTIC SYNDROME, Glycosylphosphatidylinositols | Stem Cell Exhaustion | In contrast to aplastic anemia and paroxysmal nocturnal hemoglobinuria, where PIG-A mutations arise from multipotent hematopoietic stem cells, glycosylphosphatidylinositol-anchor deficient cells in myelodysplastic syndromes appear to arise from more committed progenitors. | 22315493 |
| Aplastic Anemia, MYELODYSPLASTIC SYNDROME, Glycosylphosphatidylinositols | Stem Cell Exhaustion | We used peripheral blood flow cytometry to identify glycosylphosphatidylinositol-anchor deficient blood cells, a proaerolysin-resistant colony forming cell assay to select glycosylphosphatidylinositol-anchor deficient progenitor cells, a novel T-lymphocyte enrichment culture assay with proaerolysin selection to expand glycosylphosphatidylinositol-anchor deficient T lymphocytes, and PIG-A gene sequencing assays to identify and analyze PIG-A mutations in patients with aplastic anemia and myelodysplastic syndromes. | 22315493 |
| Aplastic Anemia | Stem Cell Exhaustion | Bone marrow versus peripheral blood as the stem cell source for sibling transplants in acquired aplastic anemia: survival advantage for bone marrow in all age groups. | 22315497 |
| Acquired aplastic anemia | Stem Cell Exhaustion | Bone marrow has been shown to be superior to peripheral blood, as a stem cell source, in young patients (<20 years of age) with acquired aplastic anemia undergoing a matched sibling transplant. | 22315497 |
| Aplastic Anemia | Stem Cell Exhaustion | This study shows that bone marrow should be the preferred stem cell source for matched sibling transplants in acquired aplastic anemia, in patients of all age groups. | 22315497 |
| Acquired aplastic anemia | Stem Cell Exhaustion | We analyzed 1886 patients with acquired aplastic anemia who received a first transplant from a human leukocyte antigen identical sibling between 1999 and 2009, with either bone marrow (n=1163) or peripheral blood (n=723) as the source of stem cells. | 22315497 |
| Drug-Induced Liver Disease | Stem Cell Exhaustion | The study discusses the putative contribution of circulating progenitor cells activated by 5-HT(2B) receptor agonists in the development of drug-induced heart disease. | 22320434 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Allogeneic stem cell transplant for multiple myeloma (MM) is one treatment associated with long-term disease-free survival. | 22327126 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cultured in vitro, these ascitic cells displayed the potential for self-renewal and long-term proliferation, and expressed the typical cancer stem/progenitor cell markers CD44(high), CD24(low), and AC133(+). | 22330345 |
| Carcinoma, Ovarian Epithelial, Ascites | Stem Cell Exhaustion | Isolation and characterization of stromal progenitor cells from ascites of patients with epithelial ovarian adenocarcinoma. | 22330345 |
| Carcinoma, Ovarian Epithelial, Ascites | Stem Cell Exhaustion | This study aimed to isolate and characterize stromal progenitor cells from the ascites of patients with epithelial ovarian adenocarcinoma (EOA). | 22330345 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | The established culture system provides an in vitro model for the selection of drugs that target cancer-associated stromal progenitor cells, and for the development of ovarian cancer treatments. | 22330345 |
| CLU protein, human, Ischemia | Stem Cell Exhaustion | Trials have reported clinical improvement and reduced need for amputation in critical limb ischemia (CLI) patients receiving therapeutic angiogenesis with stem cells. | 22330628 |
| Amyloidosis | Stem Cell Exhaustion | We developed a prognostic model based on 810 patients with newly diagnosed AL amyloidosis, which was further examined in two other datasets: 303 patients undergoing stem-cell transplantation, and 103 patients enrolled onto different clinical trials. | 22331953 |
| Specialty Type - cancer, Squamous cell carcinoma of the head and neck | Stem Cell Exhaustion | Cancer stem cell phenotype relates to radio-chemotherapy outcome in locally advanced squamous cell head-neck cancer. | 22333601 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Cancer stem cells (CSCs) tend to repopulate malignant tumours during radiotherapy and, therefore, prolongation of the overall treatment time may result in radiotherapy failure. | 22333601 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | [Risk factors of graft-versus-host disease in patients after allogeneic stem cell transplantation]. | 22335138 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease (GVHD) is the most common and most serious complication of allogeneic hematopoetic stem cell transplantation (HSCT). | 22335138 |
| Acute GVH disease | Stem Cell Exhaustion | The purpose of this study was to evaluate the influence of different factors, such as stem cell source, type of donor, conditioning regimen and acute graft-versus-host disease, on early lymphocyte recovery after transplantation. | 22337266 |
| Nasal sinus, Communicable Diseases | Stem Cell Exhaustion | Intercurrent infectious diseases in post-stem cell transplant patients: paranasal sinusitis. | 22337395 |
| Cytomegalovirus | Stem Cell Exhaustion | [Cytomegalovirus enteritis after allogeneic hematopoietic stem cell transplantation]. | 22338172 |
| Enteritis | Stem Cell Exhaustion | To analyse the clinical features, diagnostic methods and risk factors of cytomegalovirus (CMV) enteritis after allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 22338172 |
| FGR gene | Stem Cell Exhaustion | The aim of our study was to investigate the change of count and the status of cellular senescence in fetal endothelial progenitor cells (EPCs) obtained from the umbilical cord blood of women with fetal growth restriction (FGR). | 22339619 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | The rituximab combined with chemotherapy can significantly improve the therapeutic effect of the DLBCL, and hematopoietic stem cell transplantation is the best choice for treating patients with DLBCL. | 22339956 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Autologous bone marrow stem cell transplantation for the treatment of type 2 diabetes mellitus. | 22340214 |
| Diabetes Mellitus, Insulin-Dependent, Dominica | Stem Cell Exhaustion | Autologous peripheral stem cell transplantation was first reported in 2007 to treat type 1 diabetes mellitus (DM) and achieved encouraging effect, but whether similar outcome can be achieved in type 2 DM is not well demonstrated. | 22340214 |
| Neoplasms, Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | A preliminary investigation of the relationship between circulating tumor cells and cancer stem cells in patients with breast cancer. | 22340707 |
| Neoplasms, Childhood Breast Carcinoma | Stem Cell Exhaustion | In this study, we explored the relationship between the circulating tumor cells (CTC) and the CTC-cancer stem cells (CSC) in the patients with breast cancer. | 22340707 |
| Diabetes, Homeobox Protein Hox-B4 | Stem Cell Exhaustion | Diabetes down-regulated IGF-1, IGFBP-5, VEGF, SDF-1, IL-6, IL-1a and TNF-a expression and affected the expression of Bmi-1, Gfi1, Tel and Hox-B4 which could prevent premature senescence and maintain the self-renewal capacity of stem cells. | 22341692 |
| Rheumatoid Arthritis | Stem Cell Exhaustion | Dampened ERK signaling in hematopoietic progenitor cells in rheumatoid arthritis. | 22342385 |
| Rheumatoid Arthritis | Stem Cell Exhaustion | In rheumatoid arthritis (RA), hematopoietic progenitor cells (HPC) have age-inappropriate telomeric shortening suggesting premature senescence and possible restriction of proliferative capacity. | 22342385 |
| Cerebral Infarction | Stem Cell Exhaustion | Mesenchymal stem cells (MSC) from bone marrow induce neuroprotective effects and improve clinical symptoms in animal models for acute cerebral ischemia. | 22342911 |
| Hyperemia | Stem Cell Exhaustion | Relationship among endothelial response to hyperemia, bone marrow-derived progenitor cells, and parathyroid hormone in renal transplantation. | 22343335 |
| Hyperemia | Stem Cell Exhaustion | We evaluated the relationship between endothelial response to hyperemia and circulating progenitor cells (CPCs) and endothelial progenitor cells (EPCs) PTH, and genetic parameters in RTRs. | 22343335 |
| Mucopolysaccharidoses | Stem Cell Exhaustion | We assume that technical improvements such as standardised use of the laryngeal mask airway or attached tube channel videolaryngoscopes as well as a stem cell transplantation treatment of the disease helped the management of older children with mucopolysaccharidosis 1. | 22343608 |
| Hematological Disease | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (HSCT) has been widely used for treating oncological and hematological diseases. | 22344354 |
| Specialty Type - cancer | Stem Cell Exhaustion | The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in women's cancer. | 22346766 |
| Invasive Malignant Neoplasm, Neoplasms | Stem Cell Exhaustion | We demonstrate that hypermethylation at stem cell PolyComb Group Target genes (PCGTs) occurs in cytologically normal cells three years in advance of the first morphological neoplastic changes, while hypomethylation occurs preferentially at CpGs which are heavily Methylated in Embryonic Stem Cells (MESCs) and increases significantly with cancer invasion in both the epithelial and stromal tumour compartments. | 22346766 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | These findings have major implications for cancer and embryonic stem cell biology and establish the importance of systemic DNA hypomethylation for predicting prognosis in a wide range of different cancers. | 22346766 |
| Malignant Neoplasms | Stem Cell Exhaustion | [The incidence of malignancies and surveillance of hematopoietic stem cells donors--the results of the Haemato-Oncology Department University Hospital in Plzen (Pilsen) and Czech National Marrow Donors Registry observation]. | 22348219 |
| Hematologic Neoplasms, filgrastim | Stem Cell Exhaustion | Granulopoesis colony-stimulating factor filgrastim is used to mobilize peripheral stem cells but there are concerns regarding an elevated risk of haematological malignancies. | 22348219 |
| Malignant Neoplasms | Stem Cell Exhaustion | We analyzed the incidence of malignancies and the system of haematopoietic stem cells donor surveillance. | 22348219 |
| Colorectal Carcinoma, Childhood Non-Hodgkin Lymphoma, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Acute myeloid leukaemia, non-Hodgkin lymphoma, renal and colorectal carcinoma were observed in a group of 84 peripheral stem cells sibling donors, providing 337 person-years observation. | 22348219 |
| Malignant Neoplasms | Stem Cell Exhaustion | The development of malignancies in hematopoietic stem cells donors can naturally be expected. | 22348219 |
| Choroidal Detachment, Cord blood stem cell, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Bilateral choroidal detachment after cord blood stem cell transplantation in an adult patient with acute myeloid leukemia. | 22350079 |
| Choroidal Detachment | Stem Cell Exhaustion | We report on bilateral choroidal detachment after a cord blood stem cell transplantation procedure. | 22350079 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Decrease in circulating endothelial progenitor cells in treated glioma patients. | 22350374 |
| Glioma | Stem Cell Exhaustion | The role of endothelial progenitor cells (EPCs) in the neoangiogenesis of gliomas and the effects of post-surgical therapies (i.e., radiotherapy (RT) and chemotherapy) have not yet been fully elucidated. | 22350374 |
| HIV-1 Infection Pathway | Stem Cell Exhaustion | We investigated 503 peripheral blood mononuclear cell (PBMC) samples from 240 patients with iatrogenic immune suppression (71 haematopoietic stem cell recipients, 132 solid organ transplant recipients, 37 others) and 311 PBMC samples from 302 patients with HIV-1 infection for the presence of proviral XMRV by real-time polymerase chain reaction (PCR). | 22350961 |
| Liver carcinoma, Hollings Cancer Center, Malignant Neoplasms | Stem Cell Exhaustion | The Wnt pathway is a key regulator of embryonic development and stem cells, and its aberrant activation is associated with human malignancies, most notably hepatocellular carcinoma (HCC). | 22351518 |
| Multiple Myeloma | Stem Cell Exhaustion | [Induction therapy and the role of stem cell transplantation in the treatment of myeloma multiplex in patients aged below 65 years]. | 22352191 |
| Treatment related secondary malignancy, Thrombocytopenia | Stem Cell Exhaustion | Haematopoietic stem cell transplantation (HSCT) is a situation in which the haemostatic capacity is challenged by severe thrombocytopaenia, chemotherapy-associated mucosal barrier breakdown and the need for invasive procedures. | 22356103 |
| Specialty Type - cancer | Stem Cell Exhaustion | The cancer stem cell (CSC) hypothesis has been proposed to reconcile this heterogeneity. | 22357206 |
| Rett Syndrome | Stem Cell Exhaustion | To gain further insight into the role of MECP2 in human neurogenesis, we compared the neural differentiation process in mesenchymal stem cells (MSCs) obtained from a RTT patient and from healthy donors. | 22357617 |
| Cessation of life | Stem Cell Exhaustion | Incorporating data on age-dependent death of spermatogonial stem cells explains the results from all age groups. | 22359510 |
| Non-alcoholic Fatty Liver Disease | Stem Cell Exhaustion | Decreased circulating endothelial progenitor cell levels and function in patients with nonalcoholic fatty liver disease. | 22359630 |
| Non-alcoholic Fatty Liver Disease | Stem Cell Exhaustion | Here, we tested the hypothesis that patients with nonalcoholic fatty liver disease (NAFLD) might have decreased endothelial progenitor cell (EPC) levels and attenuated EPC function. | 22359630 |
| Immediate hypersensitivity | Stem Cell Exhaustion | Transfer of IgE-mediated hypersensitivity with autologous stem cell transplantation. | 22360138 |
| IgE-mediated food allergy | Stem Cell Exhaustion | In this paper, the transfer of IgE-mediated food allergy by means of autologous stem cell transplantation in a 24-years old male patient is reported. | 22360138 |
| Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | Increase in circulating endothelial progenitor cells predicts response in patients with advanced non-small-cell lung cancer. | 22360644 |
| Erectile dysfunction, Peripheral Arterial Diseases | Stem Cell Exhaustion | Arterial erectile dysfunction and peripheral arterial disease: reliability of a new phenotype of endothelial progenitor cells and endothelial microparticles. | 22362078 |
| Erectile dysfunction | Stem Cell Exhaustion | The aim of this study was to evaluate whether the blood concentrations of a new immunophenotype of circulating late endothelial progenitor cells (EPC) and endothelial microparticles (EMP) varies in patients with arterial erectile dysfunction (aED) and abnormalities in other arterial districts. | 22362078 |
| bone marrow fibrosis, Primary Myelofibrosis, Malignant Neoplasms | Stem Cell Exhaustion | Myelofibrosis (MF) is a life-threatening clonal stem cell malignancy characterized by progressive bone marrow fibrosis and ineffective hematopoiesis. | 22362131 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Treatment with 3-6 cycles of PS-341/bortezomib, adriamycin, and dexamethasone (PAD) has been explored in terms of induction therapy prior to autologous stem cell transplantation (ASCT) in patients with multiple myeloma (MM). | 22364526 |
| Osteoporosis, Postmenopausal, Calcified (qualifier) | Stem Cell Exhaustion | Association between circulating osteoblast progenitor cells and aortic calcifications in women with postmenopausal osteoporosis. | 22366195 |
| Malignant tumor of colon, Neoplasms | Stem Cell Exhaustion | Interleukin-12 inhibits the survival of human colon cancer stem cells in vitro and their tumor initiating capacity in mice. | 22366581 |
| Specialty Type - cancer | Stem Cell Exhaustion | Interleukin-12 (IL-12) is a potent immunomodulatory cytokine with unknown direct effect on the property of cancer stem cells (CSCs). | 22366581 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | Cancer stem cell marker Bmi-1 expression is associated with basal-like phenotype and poor survival in breast cancer. | 22366984 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | The purpose of present study was to examine the expression of cancer stem cell marker Bmi-1 in breast cancer tissue and to evaluate the clinical implication of Bmi-1 expression for these patients. | 22366984 |
| Specialty Type - cancer | Stem Cell Exhaustion | Prognostic value of circulating VEGFR2+ bone marrow-derived progenitor cells in patients with advanced cancer. | 22370181 |
| Aggressive behavior, Specialty Type - cancer | Stem Cell Exhaustion | We hypothesised that host-related markers, possibly reflecting tumour aggressiveness, such as circulating endothelial cells (CEC) and circulating VEGFR2(+) bone marrow-derived (BMD) progenitor cells, could have prognostic value in patients with advanced cancer enrolled in early anticancer drug development trials. | 22370181 |
| Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Chronic graft-versus-host disease (cGVHD) is a major complication after allogeneic stem cell transplantation with an adverse effect on both mortality and morbidity. | 22371184 |
| Acute GVH disease | Stem Cell Exhaustion | Graft invariant natural killer T-cell dose predicts risk of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation. | 22371885 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | We studied whether peripheral blood stem cell (PBSC) graft iNKT-cell dose affects on the occurrence of clinically significant grade II-IV aGVHD in patients (n = 57) undergoing sibling, HLA-identical allogeneic HSCT. | 22371885 |
| HIV Infections, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | [Allogeneic stem cell transplantation for acute myeloid leukemia and HIV infection--case 3/2012]. | 22374660 |
| Allogeneic Hematopoietic Stem Cell Transplantation, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | A 27-year-old male patient with a past medical history of HIV presented with acute myeloid leukemia for allogeneic hematopoietic stem cell transplantation (HSCT). | 22374660 |
| Lupus Erythematosus | Stem Cell Exhaustion | Enhanced apoptosis and senescence of bone-marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. | 22375903 |
| Lupus Erythematosus, Systemic, Encephalitis, St. Louis | Stem Cell Exhaustion | Previous studies indicated that bone marrow mesenchymal stem cells (BMSCs) from patients with systemic lupus erythematosus (SLE) exhibited impaired capacities of proliferation, differentiation, secretion of cytokines, and immune modulation. | 22375903 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Retrospective analysis of an efficient peripheral blood stem cell collection and the relation between infused cell dose and clinical outcome in patients with malignant lymphoma and multiple myeloma. | 22376221 |
| Lymphoma | Stem Cell Exhaustion | Etoposide (VP16) is a drug used not only for the treatment of lymphoma but also for the collection of peripheral blood stem cells (PBSCs). | 22376221 |
| Hematologic Neoplasms, Neoplasms | Stem Cell Exhaustion | In patients with hematologic malignancies who receive stem-cell transplantation, donors' T cells can recognize minor histocompatibility antigens on recipient cells and generate an objective response against the tumor. | 22377792 |
| Specialty Type - cancer | Stem Cell Exhaustion | Recent studies found that the stem cell-related genes Sox2, Oct4 and Klf4 are among the target genes regulated by microRNA-145 (miR-145), suggesting that miR-145 possibly plays a role in the maintenance of cancer stem cells. | 22378186 |
| Specialty Type - cancer | Stem Cell Exhaustion | Collectively, our data indicate that miR-145 plays an important role in cancer stem cell tumorigenicity, potentially via modulation of the downstream target, Oct4. | 22378186 |
| Specialty Type - cancer, Transcription Initiation | Stem Cell Exhaustion | Therefore, it is important to address the involvement of miR-145 in the key roles of cancer stem cells in cancer initiation, progression and reoccurrence. | 22378186 |
| Specialty Type - cancer | Stem Cell Exhaustion | To address the role of miR-145 in cancer stem cells, miR-145 was restored in T3A-A3 cells. | 22378186 |
| Bone Diseases, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Myelodysplastic syndromes (MDS) are clonal stem cell diseases of the bone marrow characterized by abnormalities in maturation of hematopoietic cells of all lineages. | 22381680 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Myelodysplastic syndrome (MDS) is a hematopoietic stem cell disorder. | 22382018 |
| Cessation of life, leukemia, Acute Promyelocytic Leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The potential clinical impact of data from population-based studies is exemplified with analyses from the Swedish Acute Leukemia Registry containing more than 3300 acute myeloid leukemia (AML) patients diagnosed between 1997 and 2006 with a median follow-up of 6.2 years on (1) the role of intensive combination chemotherapy for older patients with AML, (2) the impact of allogeneic stem cell transplantation on survival of younger patients with AML, and (3) the continuing problem with early deaths in acute promyelocytic leukemia. | 22383796 |
| Multiple Myeloma | Stem Cell Exhaustion | Comparable outcomes between unrelated and related donors after reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation in patients with high-risk multiple myeloma. | 22385049 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | The purpose of this study was to assess the results of allogeneic stem cell transplantation (allo-SCT) after reduced-intensity conditioning (RIC) from matched related donors (MRD) and unrelated donors (URD) in 40 patients with high-risk multiple myeloma (MM) in a single centre. | 22385049 |
| Hematologic Neoplasms | Stem Cell Exhaustion | GMA is mainly used in patients with haematological malignancies or in those who have undergone haematopoietic stem cell transplantation (HSCT). | 22385270 |
| Clostridium difficile colitis | Stem Cell Exhaustion | Clostridium difficile infection after allogeneic hematopoietic stem cell transplantation: incidence, risk factors, and outcome. | 22387347 |
| Clostridium difficile, Clostridium difficile enteritis, Communicable Diseases | Stem Cell Exhaustion | Clostridium difficile (C. difficile) infection was observed in 13% of recipients after hematopoietic stem cell transplantation (HSCT), mainly in the first month posttransplantation. | 22387347 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Risk factors were cord blood as the source of stem cells, acute graft-versus-host disease (GVHD), and total body irradiation (TBI). | 22387347 |
| Graft-vs-Host Disease, Acute GVH disease, Central Diabetes Insipidus | Stem Cell Exhaustion | TBI in the conditioning regimen, cord blood as the source of stem cells, and acute graft-versus-host disease (aGVHD) were independently associated with CDI. | 22387347 |
| Duodenal Ulcer | Stem Cell Exhaustion | Through a genome-wide association analysis with a total of 7,035 individuals with duodenal ulcer and 25,323 controls from Japan, we identified two susceptibility loci at the PSCA gene (encoding prostate stem cell antigen) at 8q24 and at the ABO blood group locus at 9q34. | 22387998 |
| Chronic liver disease | Stem Cell Exhaustion | Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. | 22388089 |
| Brain Injury, Chronic | Stem Cell Exhaustion | During chronic injury a population of bipotent hepatic progenitor cells (HPCs) become activated to regenerate both cholangiocytes and hepatocytes. | 22388089 |
| Aggressive Adult Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Mitoxantrone, etoposide, cytarabine, and melphalan (NEAM) followed by autologous stem cell transplantation for patients with chemosensitive aggressive non-Hodgkin lymphoma. | 22388671 |
| Lymphoma, Non-Hodgkin, Familial, Aggressive Adult Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Patients with chemosensitive aggressive non-Hodgkin lymphoma (NHL) could benefit from high-dose chemotherapy (HDC) followed by autologous stem cell transplantation (auto-SCT). | 22388671 |
| Hematologic Neoplasms, Immunocompromised Host | Stem Cell Exhaustion | Of 320 cases studied, 115 (36%) occurred in immunocompromised patients, including: solid or hematological malignancy (97), corticosteroids or other immunosuppressive drugs (44), solid organ or stem cell transplant (five), and other conditions (eight). | 22390624 |
| Thalassemia | Stem Cell Exhaustion | Rare complications after second hematopoietic stem cell transplantation for thalassemia major. | 22395220 |
| Paralysed, Thalassemia, Post-transplant lymphoproliferative disorder | Stem Cell Exhaustion | We describe an 11-year-old girl with thalassemia major who underwent a second hematopoietic stem cell transplantation from a matched related donor and who subsequently developed posttransplant lymphoproliferative disorder complicated by severe ascending paralysis resembling Guillian-Barre syndrome. | 22395220 |
| Hemoglobinopathies | Stem Cell Exhaustion | This case highlights the dilemma surrounding second hematopoietic stem cell transplantations in hemoglobinopathies and the need for a careful, well informed, and collaborative decision-making process by patients, families, and medical professionals. | 22395220 |
| Malignant neoplasm of stomach, Specialty Type - cancer | Stem Cell Exhaustion | Expressions of putative cancer stem cell markers ABCB1, ABCG2, and CD133 are correlated with the degree of differentiation of gastric cancer. | 22395309 |
| Malignant neoplasm of stomach, Specialty Type - cancer | Stem Cell Exhaustion | The present study was carried out to determine whether a quantitative relationship exists between the expressions of 3 cancer stem cell (CSC) markers and the degree of differentiation of gastric cancer. | 22395309 |
| Sui Chinese, Urinary Stress Incontinence | Stem Cell Exhaustion | On October 18, 2010, in "Fundeni" Clinic of Urology and Renal Transplantation we performed for the first time in Romania, stem cell implantation in the urethral sphincter in four patients with stress urinary incontinence and compared the results of the urodynamic investigations of female patients operated with pure SUI with other surgical techniques. | 22395514 |
| Urinary Stress Incontinence | Stem Cell Exhaustion | Assessing the latest minimally invasive procedures of intra and perisphincterian injection of autologous stem cells and to compare the urodynamic results at one year after different surgical procedures for genuine stress urinary incontinence by measuring their impact on urinary flow rate (Qmax) and bladder pressure at Qmax during micturition. | 22395514 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Allogeneic stem cell transplant for chronic myeloid leukemia as a still promising option in the era of the new target therapy. | 22397295 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Thus, the place and usage of allogeneic stem cell transplant (SCT) in CML treatment--as a former "nearly monopolistic" therapeutic manner--is nowadays controversial. | 22397295 |
| Eccrine dermal cylindroma, Neoplasms | Stem Cell Exhaustion | Cylindroma is a benign skin appendageal tumor arising from pluripotent stem cells in the folliculo-sebaceous-apocrine unit. | 22398229 |
| Decreased platelet count | Stem Cell Exhaustion | Immunosuppressive function of mesenchymal stem cells from human umbilical cord matrix in immune thrombocytopenia patients. | 22398715 |
| Autoimmune Diseases, Inflammatory disorder | Stem Cell Exhaustion | Human umbilical cord matrix/Wharton's jelly (hUC)-derived mesenchymal stem cells (MSC) have been shown to have marked therapeutic effects in a number of inflammatory diseases and autoimmune diseases in humans based on their potential for immunosuppression and their low immunogenicity. | 22398715 |
| Multiple Myeloma | Stem Cell Exhaustion | This study investigated the impact of prognostic variables, including the distance a patient lives from a transplant center, on the outcome of autologous hematopoietic stem cell transplantation (ASCT) for multiple myeloma. | 22398804 |
| Adult Glioblastoma, Specialty Type - cancer | Stem Cell Exhaustion | It is required for cell cycle progression and survival in established glioblastoma cell lines and cancer stem cell-enriched cells. | 22399192 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Our results showed that sex-determining region Y-box 2 expression may be a potential marker related to tumor recurrence, as implicated by its role in cancer stem cells. | 22401770 |
| Impaired T cell function | Stem Cell Exhaustion | Myostatin is associated with age-related human muscle stem cell dysfunction. | 22403007 |
| Impaired | Stem Cell Exhaustion | OMs had 35% fewer basal stem cells and a type II fiber-specific impairment in stem cell content and proliferation. | 22403007 |
| Impaired T cell function | Stem Cell Exhaustion | Stem cell-specific myostatin levels were not different at baseline; however, there were 67% more myostatin-positive type II-associated stem cells in OMs at 24 h. These data illustrate an age-related impairment of stem cell function in a fiber type-specific manner. | 22403007 |
| Cataract | Stem Cell Exhaustion | Efficient generation of lens progenitor cells from cataract patient-specific induced pluripotent stem cells. | 22403680 |
| Cataract | Stem Cell Exhaustion | Our study describes a highly efficient procedure for generating lens progenitor cells from cataract patient HLEC-derived iPSCs. | 22403680 |
| hetastarch | Stem Cell Exhaustion | However, NPC is a systemic disease; therefore the purpose of this study was to find the possibility of a general therapeutic effect by applying and tracking transplanted human amniotic epithelial stem cells (hAESC) in NPC mice. | 22404083 |
| Multiple Myeloma | Stem Cell Exhaustion | A single-center retrospective analysis compared two consecutive cohorts undergoing FIL or PEG mobilization before autologous hematopoietic stem cell transplantation for multiple myeloma or lymphoma. | 22404694 |
| Cessation of life, Dyspnea, CTCAE | Stem Cell Exhaustion | Products cryopreserved with dimethyl sulfoxide (DMSO) in stem cell transplant (SCT) often cause many adverse effects during their infusion (major cardiovascular events, dyspnea ... even death). | 22404870 |
| malignant disease | Stem Cell Exhaustion | Intravenous (IV) busulfan (Bu) dosing approved in Europe based on 5 body weight (BW) strata has been validated for targeting Bu exposures in children undergoing hematopoietic stem-cell transplantation and with mostly malignant diseases. | 22406655 |
| Keloid | Stem Cell Exhaustion | Identification of fibrocytes from mesenchymal stem cells in keloid tissue: a potential source of abnormal fibroblasts in keloid scarring. | 22407077 |
| Keloid | Stem Cell Exhaustion | Therefore, we hypothesized that a population of fibrocytes is present in keloid tissue as opposed to the mesenchymal stem cells (MSCs). | 22407077 |
| Specialty Type - cancer | Stem Cell Exhaustion | Recently, evidence in support of the cancer stem cell (CSC) hypothesis has been accumulating. | 22407396 |
| Childhood Breast Carcinoma, Primary malignant neoplasm | Stem Cell Exhaustion | On the other hand, it has been reported that the expression of aldehyde dehydrogenase 1 (ALDH1) in primary breast cancer is a powerful predictor of a poor clinical outcome, and that breast cancer stem cells express ALDH1. | 22407396 |
| Disease, palladium, Parkinson Disease | Stem Cell Exhaustion | Induced pluripotent stem cells (iPSC) offer an unprecedented opportunity to model human disease in relevant cell types, but it is unclear whether they could successfully model age-related diseases such as Parkinson's disease (PD). | 22407749 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | We determined the prognostic significance of MYC rearrangement in patients with relapsed/refractory DLBCL prospectively treated by R-ICE or R-DHAP followed by high-dose therapy and autologous stem cell transplantation. | 22408263 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Plerixafor with granulocyte-colony-stimulating factor (G-CSF) has been shown to enhance stem cell mobilization in patients with multiple myeloma and lymphoma with previous mobilization failure. | 22414093 |
| Rheumatoid Arthritis, Degenerative polyarthritis | Stem Cell Exhaustion | Chondrogenic differentiation of human subchondral progenitor cells is affected by synovial fluid from donors with osteoarthritis or rheumatoid arthritis. | 22414301 |
| Rheumatoid Arthritis, Degenerative polyarthritis | Stem Cell Exhaustion | These results suggest that in RA, SF may impair cartilage repair by subchondral mesenchymal progenitor cells in microfracture, while in OA, SF may has no negative, but a delaying effect on the cartilage matrix formation. | 22414301 |
| Neurodegenerative Disorders | Stem Cell Exhaustion | Advances in stem cell biology have generated intense interest in the prospect of transplanting stem cells into the nervous system for the treatment of neurodegenerative diseases. | 22415942 |
| Amyotrophic Lateral Sclerosis | Stem Cell Exhaustion | Lumbar intraspinal injection of neural stem cells in patients with amyotrophic lateral sclerosis: results of a phase I trial in 12 patients. | 22415942 |
| Toxic effect, Bone necrosis, Multiple Myeloma | Stem Cell Exhaustion | Hematopoietic progenitor cell transplantation toxicities in multiple myeloma patients with bisphosphonate-induced osteonecrosis of the jaw: a longitudinal cohort study. | 22418599 |
| Multiple Myeloma, Bone necrosis, Toxic effect, Osteonecrosis of Jaw, Morular Metaplasia of the Endometrium | Stem Cell Exhaustion | There is no information regarding the toxicity associated with autologous hematopoietic progenitor cell transplantation (AHPCT) in patients with multiple myeloma (MM) who have bisphosphonate-induced osteonecrosis of the jaw (ONJ). | 22418599 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Myelodysplastic syndromes are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis. | 22419576 |
| Chronic myeloproliferative disorder, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Chronic myeloid leukemia is a chronic myeloproliferative disorder of hematopoietic stem cells that occurs in 10% of cases in women of childbearing age. | 22421368 |
| Precursor cell lymphoblastic lymphoma, Acute lymphocytic leukemia | Stem Cell Exhaustion | Phase II study of intensive post-remission chemotherapy and stem cell transplantation for adult acute lymphoblastic leukemia and lymphoblastic lymphoma: Japan Clinical Oncology Group Study, JCOG9402. | 22422899 |
| Communicable Diseases | Stem Cell Exhaustion | After receiving an allogeneic haematopoietic stem cell transplant, he developed a necrotizing infection of the right midface. | 22425500 |
| Malignant Neoplasms | Stem Cell Exhaustion | Stem cell marker LIN28, related closely with SOX2 and OCT4, has been studied as a biomarker for the maintainance of pluripotent cells in several malignancies. | 22429493 |
| Communicable Diseases | Stem Cell Exhaustion | The use of a neutropenic diet (ND) after hematopoietic stem cell transplantation (HSCT) was instituted more than 30 years ago as a means of preventing infection from organisms colonizing the gastrointestinal tract. | 22430084 |
| Multiple Myeloma | Stem Cell Exhaustion | Prognostic impact of serum immunoglobulin heavy/light chain ratio in patients with multiple myeloma in complete remission after autologous stem cell transplantation. | 22430087 |
| Multiple Myeloma | Stem Cell Exhaustion | Immunoglobulin heavy/light chain (HLC) ratios were studied in 37 patients with multiple myeloma in complete remission after autologous hematopoietic stem cell transplantation. | 22430087 |
| Amyotrophic Lateral Sclerosis | Stem Cell Exhaustion | Two potential biomarkers identified in mesenchymal stem cells and leukocytes of patients with sporadic amyotrophic lateral sclerosis. | 22430187 |
| CYFIP2 gene, Retinoblastoma, Antilymphocyte Serum | Stem Cell Exhaustion | To this end we use human mesenchymal stem cells (hMSC) derived from the bone marrow of six ALS patients (ALS hMSC) and identified two genes, Cytoplasmic FMR Interacting Protein 2 (CyFIP2) and Retinoblastoma (Rb) Binding Protein 9 (RbBP9) with a significant decrease in post transcriptional A to I RNA editing compared to hMSC of healthy individuals. | 22430187 |
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Neoplasms | Stem Cell Exhaustion | Rescue by hematopoietic progenitor cells derived from engrafted cord blood unit in a child with brain tumor after transplantation for T-cell acute lymphoblastic leukemia. | 22430590 |
| Carcinogenic Chlorinated Hydrocarbon, Hollings Cancer Center | Stem Cell Exhaustion | The present results show that both HCC and CC components of most of the CHCs expressed both HCC and CC phenotypes, supporting the hypothesis that CHC originates from a hepatic progenitor cell capable of differentiating into hepatocytes and cholangiocytes. | 22431178 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Immunohistochemical detection of breast cancer stem cells in hormone receptor-positive breast cancer and their role in response to endocrine therapy and clinical outcome. | 22433454 |
| Malignant neoplasm of breast, Childhood Breast Carcinoma | Stem Cell Exhaustion | Breast cancer stem cells are rich in triple negative or human epidermal growth factor receptor-2-positive breast cancers. | 22433454 |
| Hormone Receptor Positive Breast Carcinoma | Stem Cell Exhaustion | The role of these stem cells in hormone receptor-positive breast cancers is unknown. | 22433454 |
| Hormone Receptor Positive Breast Carcinoma | Stem Cell Exhaustion | Therefore, we launched this retrospective biomarker analysis to clarify the role of stem cells in relation with endocrine therapy in hormone receptor-positive breast cancer. | 22433454 |
| Malignant tumor of colon | Stem Cell Exhaustion | Characterization of colon cancer cells: a functional approach characterizing CD133 as a potential stem cell marker. | 22433494 |
| Colon Carcinoma | Stem Cell Exhaustion | We characterized a panel of fourteen human colon carcinoma cell lines and their corresponding xenografts for the surface expression of potential stem cell markers CD133, CD24, CD44, CDCP1 and CXCR4. | 22433494 |
| Neoplasms | Stem Cell Exhaustion | All five putative stem cell markers showed distinct expression patterns in the tumours examined. | 22433494 |
| Colon Carcinoma | Stem Cell Exhaustion | Our data revealed correlations in the expression of surface markers CD44 and CD24 as well as CD44 and CDCP1 and strongly suggest that CD133 is a stem cell marker within our colon carcinoma panel. | 22433494 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Reduced-intensity conditioning allogeneic stem cell transplantation for relapsed/refractory mantle cell lymphoma: a multicenter experience. | 22440229 |
| Medial collateral ligament, Mantle cell lymphoma | Stem Cell Exhaustion | Despite therapeutic approach that combines rituximab-containing chemotherapy, followed or not by autologous stem cell transplantation (auto-SCT), mantle cell lymphoma (MCL) patients experience relapses. | 22440229 |
| Aggressive behavior, Specialty Type - cancer, Pancreatic carcinoma | Stem Cell Exhaustion | Thus, high FGFR-2 IIIc levels in PDAC contribute to disease aggressiveness and confer to pancreatic cancer cells features suggestive of cancer stem cells, indicating that FGFR-2 IIIc may be a novel and important therapeutic target in PDAC. | 22440254 |
| Aortic Aneurysm, Thoracic | Stem Cell Exhaustion | Stem cells in thoracic aortic aneurysms and dissections: potential contributors to aortic repair. | 22440369 |
| 1,3,4,6-tetra-O-acetyl-2-azido-2-deoxyglucopyranose | Stem Cell Exhaustion | Although multipotent stem cells (SCs) are important in tissue repair, their role in TAAD is unknown. | 22440369 |
| 1,3,4,6-tetra-O-acetyl-2-azido-2-deoxyglucopyranose | Stem Cell Exhaustion | Stem cells are more abundant in TAAD tissue than in normal aortic tissue. | 22440369 |
| Multiple Myeloma | Stem Cell Exhaustion | To prospectively evaluate allogeneic stem cell transplantation (allo-SCT) for myeloma as part of first-line therapy, a donor versus no-donor analysis was performed of patients treated in the HOVON-50 study, a study that was originally designed to examine thalidomide combined with intensive therapy. | 22442350 |
| Prostate carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM. | 22442719 |
| Prostate carcinoma, Specialty Type - cancer, Passive Cutaneous Anaphylaxis, Hormone refractory prostate cancer | Stem Cell Exhaustion | The emergence of castrate-resistant prostate cancer (CRPC) contributes to the high mortality of patients diagnosed with prostate cancer (PCa), which in part could be attributed to the existence and the emergence of cancer stem cells (CSCs). | 22442719 |
| Malignant Head and Neck Neoplasm | Stem Cell Exhaustion | Long-term cryopreservation model of rat salivary gland stem cells for future therapy in irradiated head and neck cancer patients. | 22443349 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Mobilized peripheral blood stem cells compared with bone marrow as the stem cell source for unrelated donor allogeneic transplantation with reduced-intensity conditioning in patients with acute myeloid leukemia in complete remission: an analysis from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation. | 22446014 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Reduced-intensity conditioning allogeneic stem cell transplant (RIC-alloSCT) is being increasingly used for patients with acute myelogenous leukemia (AML) with comorbidities. | 22446014 |
| Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Patients without chronic graft-versus-host disease (cGVHD) have robust B cell reconstitution and are able to maintain B cell homeostasis after allogeneic hematopoietic stem cell transplantation (HSCT). | 22446015 |
| Multiple Myeloma | Stem Cell Exhaustion | Lenalidomide plus donor-lymphocytes infusion after allogeneic stem-cell transplantation with reduced-intensity conditioning in patients with high-risk multiple myeloma. | 22446605 |
| Cessation of life | Stem Cell Exhaustion | Myeloma relapse is the main cause of death after allogeneic stem cell transplantation. | 22446605 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Lenalidomide is well tolerated after allogeneic stem cell transplantation; the combination with DLI did not cause a higher risk of graft-vs-host disease; an immunological synergistic effect was probably present with this strategy. | 22446605 |
| Multiple Myeloma | Stem Cell Exhaustion | A simplified method for autologous stem cell transplantation in multiple myeloma. | 22446610 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | We evaluated the efficacy and safety of non-cryopreserved storage of autologous hematopoietic stem cells with no post-transplant granulocyte colony-stimulating factor (G-CSF) support in adult patients undergoing autologous stem cell transplantation (ASCT) for multiple myeloma (MM). | 22446610 |
| Malignant Neoplasms | Stem Cell Exhaustion | T-cell replete fludarabine/cyclophosphamide reduced intensity allogeneic stem cell transplantation for lymphoid malignancies. | 22449197 |
| Graft-vs-Host Disease, Malignant Neoplasms | Stem Cell Exhaustion | The relative merits of reduced-intensity allogeneic stem cell transplantation (RISCT) for high-risk indolent lymphoid malignancies are emerging, although the preferred conditioning regimen to manage the risks of graft-versus-host disease (GVHD) is not clearly defined. | 22449197 |
| Acute myocardial infarction | Stem Cell Exhaustion | To determine whether newer combination cytokine treatment with granulocyte colony-stimulating factor (G-CSF) and darbepoetin can improve efficacy of stem cell therapy, we evaluated safety and peripheral blood stem/progenitor cell (PBSC) mobilizing effects of combination cytokine in comparison with G-CSF alone in patients with acute myocardial infarction (AMI). | 22449332 |
| Bladder neck obstruction | Stem Cell Exhaustion | The present study is to investigate if human mesenchymal stem cells (MSCs) are capable of inhibiting collagen deposition and improve cystometric parameters in bladder outlet obstruction in rats. | 22449414 |
| Atherosclerosis | Stem Cell Exhaustion | CV progenitor cells, including CD34+ cells, play a role in delaying the progression of atherosclerosis. | 22449458 |
| Barrett Esophagus | Stem Cell Exhaustion | Cdx2 expression in esophageal stem cells induced by reflux bile acids may be an important factor for development of Barrett's esophagus, whereas Notch signaling is a molecular signaling pathway that plays an important role in the determination of cell differentiation. | 22449796 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | [Sustained complete molecular remission after cessation of imatinib mesylate treatment in a patient with relapsed chronic myelogenous leukemia after allogeneic stem cell transplantation]. | 22450581 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | We present a case with sustained complete molecular response (CMR) after cessation of two months of imatinib mesylate (IM) treatment for chronic myelogenous leukemia (CML) relapsed after allogeneic stem cell transplantation (Allo-SCT). | 22450581 |
| Multiple Myeloma | Stem Cell Exhaustion | [B-cell acute lymphoblastic leukemia developed 5 years after autologous stem cell transplantation for multiple myeloma]. | 22450582 |
| Renal dysfunction | Stem Cell Exhaustion | It was difficult for him to receive hemopoietic stem cell transplantation because of his advanced age and renal dysfunction. | 22450587 |
| Blastic plasmacytoid dendritic cell neoplasm | Stem Cell Exhaustion | Although previously not reported, ABVD therapy is useful for patients with blastic plasmacytoid dendritic cell neoplasm who cannot receive hemopoietic stem cell transplantation. | 22450587 |
| Communicable Diseases | Stem Cell Exhaustion | According to a model described by Balducci, the human myelopoietic stem cell reserve shows a shift from the reproductive to the proliferative pool corresponding to higher immunological demands resulting from the breakdown of infection defences. | 22451304 |
| Sepsis | Stem Cell Exhaustion | Every "hematopoietic stress," i.e., sepsis and/or cytoreductive chemotherapy, leads to a reduction of myelopoietic stem cells in the elderly in contrast to an increase in younger individuals. | 22451304 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | Blood levels of stem cell marker proteins CD34 and osteonectin were studied in male patients with coronary atherosclerosis by direct biomagnetic separation of proteins with magnetic microspheres using the PureProteome Protein A and Protein G Magnetic Beads proteomic technology. | 22451890 |
| Atherosclerosis, Calcinosis | Stem Cell Exhaustion | The results indicate that osteonectin as a marker of stromal stem cells with osteogenic potential presumably plays an important role in atherogenesis and can serve as a new biomarker of stenosing atherosclerosis and calcinosis of coronary arteries. | 22451890 |
| Multiple Myeloma | Stem Cell Exhaustion | Melphalan 180 mg/m2 can be safely administered as conditioning regimen before an autologous stem cell transplantation (ASCT) in multiple myeloma patients with creatinine clearance 60 mL/min/1.73 m2 or lower with use of palifermin for cytoprotection: results of a phase I trial. | 22453252 |
| Hodgkin Disease, LIPC gene | Stem Cell Exhaustion | In this multinational, open-label, phase II study, the efficacy and safety of brentuximab vedotin were evaluated in patients with relapsed or refractory Hodgkin's lymphoma (HL) after autologous stem-cell transplantation (auto-SCT). | 22454421 |
| FLT3 Internal Tandem Duplication | Stem Cell Exhaustion | FLT3-ITD is associated with poor clinical outcome and is an indication for allogeneic stem cell transplantation (allo-SCT). | 22458420 |
| leukemia | Stem Cell Exhaustion | Most patients had leukemia, 44 underwent high-dose chemotherapy, and 18 underwent stem cell transplantation. | 22459769 |
| Liver Failure, Chronic graft-versus-host disease | Stem Cell Exhaustion | Liver transplantation in a child with liver failure due to chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation from the same unrelated living donor. | 22462486 |
| BCR gene | Stem Cell Exhaustion | The boy received an allogeneic hematopoietic stem cell transplant at the age of two yr because of early recurrence of ALL. | 22462486 |
| Graft-vs-Host Disease, Liver Cirrhosis | Stem Cell Exhaustion | Liver biopsy showed liver GVHD resulting in liver cirrhosis by the age of five yr. LTx was performed with a left liver lobe from the unrelated donor from whom the stem cells had been taken. | 22462486 |
| Acute myocardial infarction | Stem Cell Exhaustion | Treatment of acute myocardial infarction with stem cell transplantation has achieved beneficial effects in many clinical trials. | 22462635 |
| Overweight, "cytidylyl-(3-5)-cytidine | Stem Cell Exhaustion | To assess the effect of a personalized physical activity programme on weight and circulating (CPC) and endothelial progenitor cells (EPC) in overweight and obese subjects. | 22463054 |
| Communicable Diseases | Stem Cell Exhaustion | Healthcare-associated infection in hematopoietic stem cell transplantation patients: risk factors and impact on outcome. | 22463920 |
| Infections, Hospital, Infection | Stem Cell Exhaustion | The objective of this study was to analyze the incidence of and risk factors for healthcare-associated infections (HAI) among hematopoietic stem cell transplantation (HSCT) patients, and the impact of such infections on mortality during hospitalization. | 22463920 |
| Specialty Type - cancer | Stem Cell Exhaustion | We also assessed other claudin-low features, such as the cancer stem cell-like and epithelial-to-mesenchymal transition phenotypes. | 22464177 |
| Specialty Type - cancer | Stem Cell Exhaustion | Regarding the cancer stem cell marker ALDH1, 30.8% (4/13) showed positive staining. | 22464177 |
| Childhood Breast Carcinoma, Metaplastic carcinoma of breast | Stem Cell Exhaustion | The negative/low expression of claudins and E-cadherin, high levels of vimentin, and the breast cancer stem cell phenotype suggests that metaplastic breast carcinomas have similar features to the ones included in the claudin-low molecular subtype, specially their mesenchymal components. | 22464177 |
| Neoplasms | Stem Cell Exhaustion | The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor. | 22464327 |
| Neoplasms | Stem Cell Exhaustion | These results shed light on the relationship between proliferative and quiescent intestinal stem cells and support a model in which intestinal stem cell quiescence is maintained by calibrated ErbB signaling with loss of a negative regulator predisposing to neoplasia. | 22464327 |
| Childhood Breast Carcinoma, Neoplasms | Stem Cell Exhaustion | In this study, TIMP-1 production was studied in a co-culture model of hormone-independent breast cancer cell lines and mesenchymal stem cells mimicking the stromal components of the tumor. | 22465225 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Co-culturing of mesenchymal stem cells and breast cancer cells resulted in positive immunocytochemical diffuse staining for TIMP-1 for both cell types. | 22465225 |
| Retinal Detachment | Stem Cell Exhaustion | Furthermore, cells isolated from vitreous samples obtained during vitrectomies for retinal detachment were directly fixed or cultured in a stem cell-promoting medium and compared to cells cultured from the post-mortem retina and CE. | 22465407 |
| trauma qualifier | Stem Cell Exhaustion | In addition to the ability for self-renewal and functional differentiation, neural stem/progenitor cells (NSCs) can respond to CNS injuries by targeted migration. | 22465407 |
| Peripheral | Stem Cell Exhaustion | In conclusion, the adult human eye may harbor two different populations of neuroepithelial stem/progenitor cells; a non-glial population located in the proximal pars plana around peripheral cysts in addition to a population with Muller glia characteristics. | 22465407 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Overall survival of chronic myeloid leukemia patients treated with related donor hematopoietic stem cell transplant or imatinib. | 22468479 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | To determine the overall survival (OS) of Ph1 positive chronic myeloid leukemia (CML) patients treated with allogeneic hematopoietic stem cell transplant (AHSCT) vs. imatinib. | 22468479 |
| Pleuropulmonary blastoma, Follicular thyroid carcinoma | Stem Cell Exhaustion | Follicular thyroid carcinoma arising after hematopoietic stem cell transplantation in a child with pleuropulmonary blastoma. | 22468940 |
| Mycoses | Stem Cell Exhaustion | Multicenter, randomized, open-label study comparing the efficacy and safety of micafungin versus itraconazole for prophylaxis of invasive fungal infections in patients undergoing hematopoietic stem cell transplant. | 22469884 |
| Neutropenia, Mycoses | Stem Cell Exhaustion | This multicenter, randomized, open-label phase III study compared the efficacy and safety of micafungin and itraconazole in prophylaxis of invasive fungal infections in neutropenic patients undergoing hematopoietic stem cell transplants in China. | 22469884 |
| CLU protein, human, Ischemia | Stem Cell Exhaustion | Stem cell therapy has been proposed to be an alternative therapy in patients with critical limb ischemia (CLI), not eligible for endovascular or surgical revascularization. | 22472173 |
| CLU protein, human | Stem Cell Exhaustion | Both IM and IA delivery of autologous stem cells are effective therapeutic strategies in patients with CLI. | 22472173 |
| Acquired aplastic anemia | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplant for adults over 40 years old with acquired aplastic anemia. | 22472480 |
| Aplastic Anemia | Stem Cell Exhaustion | Although younger age is associated with favorable prognosis in adults undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) for aplastic anemia (AA), other pretransplantation factors may be more important than age. | 22472480 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | Prognosis after high-dose chemotherapy followed by autologous stem-cell transplantation as first-line treatment in primary CNS lymphoma--a long-term follow-up study. | 22473593 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | High-dose chemotherapy followed by autologous stem-cell transplantation (HCT-ASCT) is a promising approach in eligible patients with primary central nervous system lymphoma (PCNSL). | 22473593 |
| Disease of capillaries, diabetic | Stem Cell Exhaustion | Amelioration of glucose control mobilizes circulating pericyte progenitor cells in type 2 diabetic patients with microangiopathy. | 22474419 |
| Coronary Arteriosclerosis, Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Procalcific phenotypic drift of circulating progenitor cells in type 2 diabetes with coronary artery disease. | 22474430 |
| Coronary Arteriosclerosis, Dominica, Diabetes Mellitus | Stem Cell Exhaustion | Diabetes mellitus (DM) alters circulating progenitor cells relevant for the pathophysiology of coronary artery disease (CAD). | 22474430 |
| Vascular calcification | Stem Cell Exhaustion | While endothelial progenitor cells (EPCs) are reduced, there is no data on procalcific polarization of circulating progenitors, which may contribute to vascular calcification in these patients. | 22474430 |
| diabetic | Stem Cell Exhaustion | In conclusion, circulating progenitor cells of diabetic patients show a phenotypic drift toward a pro-calcific phenotype that may be driven by inflammatory signals. | 22474430 |
| Specialty Type - cancer | Stem Cell Exhaustion | However, it was directly related to protein expression of the previously studied cancer stem cell marker Nestin (p = 0.01) and the gap junction protein claudin-7 (p = 0.02) and inversely related to the mRNA level of the E-cadherin repressor SIP1 (p = 0.02). | 22476403 |
| gliosarcoma | Stem Cell Exhaustion | The histogenesis of the osseous element in gliosarcomas is not well understood, and could be a result of a metaplastic change or divergent differentiation from a common progenitor cell. | 22476731 |
| Adenovirus Infections | Stem Cell Exhaustion | Incidence and treatment strategy for disseminated adenovirus disease after haploidentical stem cell transplantation. | 22476883 |
| Communicable Diseases | Stem Cell Exhaustion | Adenovirus (AdV) infection is an emerging complication in patients undergoing allogeneic stem cell transplantation (SCT) and is closely associated with delayed immune reconstitution. | 22476883 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Despite extensive study, the use of allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia (AML) vary considerably. | 22476996 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | In anticipation of the urgent surgery for stomach cancer, an endothelial progenitor cell Genous capture stent (Orbus Neich Medical Technology) was implanted. | 22477758 |
| Hematologic Neoplasms, Neoplasms, Harvesting of peripheral blood stem cells | Stem Cell Exhaustion | We retrospectively reviewed medical records from a total of 248 patients affected by hematological malignancies or solid tumors undergoing peripheral blood stem cell collection following chemotherapy plus G-CSF. | 22480954 |
| Colorectal Carcinoma, Specialty Type - cancer, Cytogenetic Complete Response | Stem Cell Exhaustion | The activated leukocyte cell adhesion molecule (ALCAM, CD166) has been reported to be involved in tumorigenesis of colorectal cancer (CRC) and to function as a cancer stem cell marker. | 22482754 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | We studied 172 patients for development of ocular graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (allo-SCT) from 2002 to 2009. | 22484321 |
| Multiple Myeloma | Stem Cell Exhaustion | Growth factor plus preemptive ('just-in-time') plerixafor successfully mobilizes hematopoietic stem cells in multiple myeloma patients despite prior lenalidomide exposure. | 22484324 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Delayed formation of FancD2 foci in glioma stem cells treated with ionizing radiation. | 22484854 |
| Glioblastoma Multiforme Pathway, Malignant Neoplasms | Stem Cell Exhaustion | Its malignancy is in part due to cell populations refractory to radiotherapy and chemotherapy, which in some patients display stem properties (glioma stem cells-GSC). | 22484854 |
| Specialty Type - cancer, Neoplasms, Nanospheres | Stem Cell Exhaustion | In addition, we identified upregulation of these genes in the A375 cell line's side population (SP) and melanospheres, established methods to enrich for candidate cancer stem cells (CSCs), which are considered chemoresistant and tumorigenic, and thus proposed to be responsible for tumor relapse. | 22486811 |
| Staphylococcus epidermidis | Stem Cell Exhaustion | Linezolid-induced pure red cell aplasia in a patient with Staphylococcus epidermidis infection after allogeneic stem cell transplantation. | 22487245 |
| Kidney Failure, Myelosuppression, Bone Marrow Suppression | Stem Cell Exhaustion | It is important to be aware of the hematological effects associated with LZD in the setting of stem cell transplantation,particularly for those with pre-existing myelosuppression, renal insufficiency, and those receiving concomitant drugs that produce bone marrow suppression. | 22487245 |
| Atherosclerosis, Metabolic Syndrome X, ETV3 gene | Stem Cell Exhaustion | A reduction in EPC (endothelial progenitor cell) number could explain the development and progression of atherosclerosis in the MetS (metabolic syndrome). | 22489903 |
| Metabolic Syndrome X | Stem Cell Exhaustion | Moderate-to-high-intensity training and a hypocaloric Mediterranean diet enhance endothelial progenitor cells and fitness in subjects with the metabolic syndrome. | 22489903 |
| Hematologic Neoplasms | Stem Cell Exhaustion | The more, the less: age and chemotherapy load are predictive of poor stem cell mobilization in patients with hematologic malignancies. | 22490480 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Intensive treatment such as autologous peripheral blood stem cell (PBSC) transplantation is an important therapeutic strategy in many hematologic malignancies. | 22490480 |
| Orthomyxoviridae | Stem Cell Exhaustion | These observations suggest the possible involvement of lung stem/progenitor cells in influenza virus infection. | 22491467 |
| Acute GVH disease | Stem Cell Exhaustion | Acute graft-versus-host disease is a severe complication of allogeneic stem cell transplantation in which the functional immune cells of the donor recognize the recipient as foreign and mount an immunological attack. | 22491736 |
| Acute GVH disease | Stem Cell Exhaustion | In the present study, a novel bioinformatics framework was used to identify gene expression patterns associated with acute graft-versushost disease in patients undergoing allogeneic hematopoietic stem cell transplantation. | 22491736 |
| Acute GVH disease | Stem Cell Exhaustion | According to our integrated methodology, transcripts for FOXP3, ICOS, CD52 and CASP1, genes involved in immune alloreactive responses and participating in immune cell interactions, were identified as the most informative biomarkers in allogeneic stem cell transplant recipients experiencing acute graft-versus-host disease. | 22491736 |
| Primary Myelofibrosis, Chronic graft-versus-host disease | Stem Cell Exhaustion | Dynamic International Prognostic Scoring System scores, pre-transplant therapy and chronic graft-versus-host disease determine outcome after allogeneic hematopoietic stem cell transplantation for myelofibrosis. | 22491742 |
| Myeloproliferative disease, Primary Myelofibrosis | Stem Cell Exhaustion | Myelofibrosis is a myeloproliferative stem cell disorder curable exclusively by allogeneic hematopoietic stem cell transplantation and is associated with substantial mortality and morbidity. | 22491742 |
| Primary Myelofibrosis | Stem Cell Exhaustion | We retrospectively assessed 76 consecutive patients with primary (n=47) or secondary (n=29) myelofibrosis who underwent bone marrow (n=6) or peripheral blood stem cell (n=70) transplantation from sibling (n=30) or unrelated (n=46) donors between January 1994 and December 2010. | 22491742 |
| Primary Myelofibrosis | Stem Cell Exhaustion | The data corroborate a strong correlation between alloreactivity and long-term post-transplant disease control and confirm an inverse relationship between disease stage, pharmacotherapy and outcome after allogeneic hematopoietic stem cell transplantation for myelofibrosis. | 22491742 |
| Primary Myelofibrosis | Stem Cell Exhaustion | The Dynamic International Prognostic Scoring System was demonstrated to be useful for risk stratification of patients with myelofibrosis who are to undergo hematopoietic stem cell transplantation. | 22491742 |
| palladium | Stem Cell Exhaustion | Our findings indicate that future cell-based therapies using fetal tissue or stem cells in PD patients may require additional grafts of serotonergic neurons to relieve nonmotor symptoms by restoring serotonergic neurotransmission in specific cerebral targets. | 22491951 |
| Central neuroblastoma | Stem Cell Exhaustion | Thiotepa and melphalan based single, tandem, and triple high dose therapy and autologous stem cell transplantation for high risk neuroblastoma. | 22492714 |
| HD Term Type | Stem Cell Exhaustion | Consolidation with high-dose (HD) chemotherapy and autologous stem cell transplantation (ASCT) has been intensified with tandem and triple cycles with promising results. | 22492714 |
| Neoplasms | Stem Cell Exhaustion | One hundred tumour samples of CUP were loaded in tissue microarrays and were studied for immunohistochemical (IHC) expression of E-cadherin, N-cadherin, vimentin, the EMT transcription factor (SNAIL) and the stem cell marker octamer-binding transcription marker 4(OCT4). | 22493359 |
| Leukemia, T-Cell | Stem Cell Exhaustion | Allogeneic stem-cell transplantation from matched, related donors was associated with improved outcomes in T-cell leukemia. | 22494120 |
| Leukemia, T-Cell | Stem Cell Exhaustion | Patients who have T-cell leukemia appear to have a better outcome with allogeneic stem-cell transplantation than with chemotherapy, whereas patients who have precursor B-cell leukemia without other adverse features appear to have a better outcome with chemotherapy. | 22494120 |
| melanoma | Stem Cell Exhaustion | Cells from surgical specimens of nodular melanoma were grown as anchorage-independent melanospheres in a stem cell medium and as adherent monolayer cultures in the presence of serum. | 22495670 |
| Acute leukemia | Stem Cell Exhaustion | Reduced-intensity conditioning transplantation in acute leukemia: the effect of source of unrelated donor stem cells on outcomes. | 22496153 |
| Ischemia | Stem Cell Exhaustion | Safety and effect of adipose tissue-derived stem cell implantation in patients with critical limb ischemia: a pilot study. | 22498564 |
| CLU protein, human | Stem Cell Exhaustion | The safety and efficacy of multiple intramuscular adipose tissue-derived mesenchymal stem cells (ATMSC) injections in CLI patients was determined in the study. | 22498564 |
| Myeloid neoplasm | Stem Cell Exhaustion | [Allogeneic hematopoietic stem cell transplantation with fludarabine, melphalan, and total body irradiation as a conditioning for elderly patients with myeloid malignancies]. | 22499048 |
| Hematologic Neoplasms | Stem Cell Exhaustion | A variety of reduced-intensity conditionings have been used in the reported studies of allogeneic hematopoietic stem cell transplantation (HSCT) for elderly patients with myeloid hematological malignancies. | 22499048 |
| Eosinophil count raised (finding) | Stem Cell Exhaustion | Eosinophilia, regardless of degree, is related to better outcomes after allogeneic hematopoietic stem cell transplantation. | 22504238 |
| Up, Urogenital Abnormalities | Stem Cell Exhaustion | We conclude that neurogenic abnormalities in AD differ between phases and areas of neurogenesis and stages of AD; while hippocampal stem cells (Musashi-1) decrease, proliferation (nestin) increases and differentiation/migration phase as well as axonal/dendritic targeting (doublecortin and b-III-tubulin) remains virtually unchanged. | 22504537 |
| Up | Stem Cell Exhaustion | This suggests an attenuation of stem cells together with compensatory increased proliferation that, however, does not result in an increased number of migratory neuroblasts and differentiated neurons in AD. | 22504537 |
| Bladder neck obstruction | Stem Cell Exhaustion | Mesenchymal stem cells overexpressing hepatocyte growth factor (HGF) inhibit collagen deposit and improve bladder function in rat model of bladder outlet obstruction. | 22506988 |
| Bladder neck obstruction, BCL2L10 wt Allele | Stem Cell Exhaustion | This study was performed to examine the capability of human mesenchymal stem cells (MSCs) overexpressing hepatocyte growth factor (HGF) to inhibit collagen deposition in rat model of bladder outlet obstruction (BOO). | 22506988 |
| Acute Coronary Syndrome | Stem Cell Exhaustion | Endothelial progenitor cells are suppressed in anemic patients with acute coronary syndrome. | 22507545 |
| Ischemia | Stem Cell Exhaustion | Endothelial progenitor cells are bone marrow-derived cells that are mobilized into the circulation in response to ischemia. | 22507545 |
| Acute Coronary Syndrome | Stem Cell Exhaustion | The number of circulating endothelial progenitor cells increases within days of acute coronary syndrome. | 22507545 |
| Anemia, Acute Coronary Syndrome | Stem Cell Exhaustion | There is no confirmation regarding the correlation between the occurrence of anemia and the deficiency in endothelial progenitor cells in patients with acute coronary syndrome. | 22507545 |
| Anemia, Acute Coronary Syndrome | Stem Cell Exhaustion | The correlation between chronic anemia and endothelial progenitor cells in patients with acute coronary syndrome was investigated. | 22507545 |
| Acute Coronary Syndrome | Stem Cell Exhaustion | Endothelial progenitor cells were examined in 26 patients with acute coronary syndrome. | 22507545 |
| Anemia, Acute Coronary Syndrome | Stem Cell Exhaustion | Patients with acute coronary syndrome with anemia demonstrate a reduced number of peripheral endothelial progenitor cells with impaired function, possibly representing a lower capacity for vascular healing. | 22507545 |
| Antilymphocyte Serum | Stem Cell Exhaustion | Feasibility, safety, and preliminary proof of principles of autologous neural stem cell treatment combined with T-cell vaccination for ALS patients. | 22507681 |
| Antilymphocyte Serum | Stem Cell Exhaustion | TCV in conjunction with an autologous neural stem cell treatment might be a feasible, minimally invasive, safe, and effective approach to obtain enduring therapeutic effects in ALS patients. | 22507681 |
| Multiple Myeloma | Stem Cell Exhaustion | The next step forward was the use of high-dose melphalan followed by stem cell support (autologous stem cell transplant - ASCT) for young myeloma patients, which resulted in a significant improvement in disease free survival and overall survival. | 22507766 |
| Aplastic Anemia | Stem Cell Exhaustion | Search terms included severe aplastic anemia, HLA-matched sibling, unrelated donor, hematopoietic stem cell transplantation. | 22507769 |
| Graft-vs-Host Disease, Cessation of life | Stem Cell Exhaustion | The use of peripheral blood progenitor cells has also contributed to higher GVHD risks and consequently excess deaths. | 22507769 |
| Coinfection, HIV | Stem Cell Exhaustion | A number of challenges are faced in terms of reimbursement of drugs, simultaneous co-infection with human immunodeficiency virus, access to allogeneic stem cell transplantation and, until recently, a lack of local recommendations appropriate for our setting. | 22507786 |
| Carcinoma | Stem Cell Exhaustion | These combined carcinomas may arise from enterochromaffin cells or totipotential stem cell in the esophagus or transdifferentiation of one element to another. | 22509088 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Cytokines in tear fluid of patients with ocular graft-versus-host disease after allogeneic stem cell transplantation. | 22509110 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | To investigate the profile of cytokines in tear fluid of patients after allogeneic stem cell transplantation (allo-SCT) and determine their relation to the presence and manifestations of ocular graft-versus-host disease (GvHD). | 22509110 |
| Restenosis | Stem Cell Exhaustion | Hematopoietic progenitor cells and restenosis after carotid endarterectomy. | 22511008 |
| Vascular System Injuries | Stem Cell Exhaustion | Hematopoietic progenitor cells (HPCs) may attenuate the response to vascular injury by maintaining endothelial integrity and function. | 22511008 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | High curability via intensive reinduction chemotherapy and stem cell transplantation in young adults with relapsed acute lymphoblastic leukemia in Sweden 2003-2007. | 22511497 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | Allogeneic stem cell transplantation remains the treatment of choice for young adults with relapsed acute lymphoblastic leukemia. | 22511497 |
| Muscular Dystrophy, Duchenne, Cardiomyopathies | Stem Cell Exhaustion | To investigate whether cardiac progenitor cells (CPCs) isolated from healthy and GRMD dogs may differentiate into myocardial cell types and to test the feasibility of cell therapy for cardiomyopathies in a preclinical model of DMD, CPCs were isolated from cardiac biopsies of healthy and GRMD dogs. | 22513051 |
| Ischemic stroke | Stem Cell Exhaustion | Temporal profile of molecular signatures associated with circulating endothelial progenitor cells in human ischemic stroke. | 22513751 |
| Ischemic stroke | Stem Cell Exhaustion | Endothelial progenitor cells (EPC) have been associated with good functional outcome in ischemic stroke. | 22513751 |
| Acute Megakaryocytic Leukemias | Stem Cell Exhaustion | 2 children with unknown trisomy 21 mosaic were diagnosed as acute megakaryoblastic leukemia (AMKL) and treated according the high risk arm of the AML-BFM 2004 including allogeneic stem cell transplantation in one child). | 22513796 |
| Retinal Pigments | Stem Cell Exhaustion | Differentiation of human pluripotent stem cells to retinal pigmented epithelium in defined conditions using purified extracellular matrix proteins. | 22514096 |
| methyldopa, Retinal Diseases, Retinal Pigments | Stem Cell Exhaustion | A potential application of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) is the generation of retinal pigmented epithelium (RPE) to treat age-related macular degeneration (AMD), a common but incurable retinal disease. | 22514096 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Comparison of allogeneic stem cell transplantation from familial-mismatched/haploidentical donors and from unrelated donors in adults with high-risk acute myelogenous leukemia. | 22516055 |
| Central neuroblastoma | Stem Cell Exhaustion | New therapies for children with high risk neuroblastoma are needed, and haploidentical stem cell transplantation with NK post-graft injections is a potential option. | 22516232 |
| Neoplasms | Stem Cell Exhaustion | The aim of this work is to optimize in vitro NK cytotoxicity assays, investigate the effect of interleukin stimulation on NK cells and use of antiGD2 antibodies against tumor target cells and finally establish an in vitro model for haploidentical stem cell transplantation. | 22516232 |
| Stomach Carcinoma, Histogenic Process, Cholangiocarcinoma | Stem Cell Exhaustion | The histogenesis of hepatoid gastric carcinoma expressing SALL4 seems to reflect fetal gut differentiation or involve the germ cell lineage and may be different from that of combined hepatocellular and cholangiocarcinoma involving the hepatic stem cell or progenitor cell lineages. | 22516245 |
| Acute leukemia | Stem Cell Exhaustion | Our results indicate that DDR is a rate-limiting event for acquisition of stem cell-like properties in MLL-ENL-ERtm-mediated transformation, as experimental inhibition of the barrier accelerated the transition to immature cell states and acute leukemia development. | 22516260 |
| BCR-ABL Fusion Gene, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Compared with imatinib, nilotinib is a potent breakpoint cluster region/v-abl Abelson murine leukemia viral oncogene (bcr-abl) kinase inhibitor, and it induces higher rate and rapid complete cytogenetic response (CCyR), yet no clinical data are available regarding its efficacy against chronic myeloid leukemia (CML) stem cells. | 22517301 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Evaluation of residual CD34(+) Ph(+) progenitor cells in chronic myeloid leukemia patients who have complete cytogenetic response during first-line nilotinib therapy. | 22517301 |
| Myocardial necrosis | Stem Cell Exhaustion | Remote ischemic preconditioning immediately before percutaneous coronary intervention does not impact myocardial necrosis, inflammatory response, and circulating endothelial progenitor cell counts: a single center randomized sham controlled trial. | 22517646 |
| Infection | Stem Cell Exhaustion | The main factors associated with deteriorating quality of life over time were found to be significant infections, female gender and transplantation with stem cells from a sibling donor. | 22519415 |
| Leukemia, Myelocytic, Acute, Acute leukemia | Stem Cell Exhaustion | Bone marrow or peripheral blood stem cell transplantation from unrelated donors in adult patients with acute myeloid leukaemia, an Acute Leukaemia Working Party analysis in 2262 patients. | 22519980 |
| Graft-vs-Host Disease, Acute GVH disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | The incidence of acute graft-versus-host disease (GVHD) was similar, but there was more chronic GVHD in the blood stem cell group [hazard ratio (HR) = 1.29, P = 0.02]. | 22519980 |
| Li-Fraumeni Syndrome, leukemia | Stem Cell Exhaustion | In patients with advanced leukaemia, the blood stem cell group had reduced NRM and improved LFS. | 22519980 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | In a retrospective registry analysis, we compared the use of blood stem cells (n = 1502) and BM (n = 760) from unrelated donors in patients aged 18-60 years with acute myeloid leukaemia (AML) undergoing myeloablative conditioning between 1997 and 2008. | 22519980 |
| Li-Fraumeni Syndrome, leukemia | Stem Cell Exhaustion | In patients with advanced leukaemia, NRM was lower (HR = 0.61, P = 0.02) and LFS was prolonged (HR = 0.67, P = 0.002) when blood stem cells were used. | 22519980 |
| Li-Fraumeni Syndrome, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Blood stem cells compared with BM in MUD transplantation for patients with AML in remission resulted in the same rates of LFS. | 22519980 |
| Heart failure | Stem Cell Exhaustion | Monocyte-derived and CD34+/KDR+ endothelial progenitor cells in heart failure. | 22519984 |
| Heart failure | Stem Cell Exhaustion | Endothelial progenitor cells (EPCs) are known to be altered in heart failure (HF), but monocyte-derived EPCs in HF have not been assessed. | 22519984 |
| Diabetes | Stem Cell Exhaustion | Downregulation of microRNA-126 in endothelial progenitor cells from diabetes patients, impairs their functional properties, via target gene Spred-1. | 22525256 |
| Dominica, Diabetes Mellitus | Stem Cell Exhaustion | Diabetes mellitus (DM) adversely affects the number and function of circulating endothelial progenitor cells (EPCs). | 22525256 |
| Acute myocardial infarction | Stem Cell Exhaustion | A potent soluble epoxide hydrolase inhibitor, t-AUCB, acts through PPARg to modulate the function of endothelial progenitor cells from patients with acute myocardial infarction. | 22525341 |
| Acute myocardial infarction | Stem Cell Exhaustion | In this work, we investigated whether increasing EETs with the sEH inhibitor t-AUCB would increase angiogenesis related function in endothelial progenitor cells (EPCs) from patients with acute myocardial infarction (AMI). | 22525341 |
| Fatigue, Sarcopenia | Stem Cell Exhaustion | Prevalence of sarcopenia and relevance of body composition, physiological function, fatigue, and health-related quality of life in patients before allogeneic hematopoietic stem cell transplantation. | 22526152 |
| Sarcopenia | Stem Cell Exhaustion | We believe that allogeneic hematopoietic stem cell transplant (allo-HSCT) patients often exhibit sarcopenia prior to transplantation. | 22526152 |
| Structure of suprasellar region, Pituitary Adenoma | Stem Cell Exhaustion | Moreover, in the present case, the suprasellar tumor remained visible after autologous peripheral stem cell transplant, likely due to the residual pituitary adenoma. | 22527852 |
| Fracture | Stem Cell Exhaustion | Significance of circulating endothelial progenitor cells in patients with fracture healing process. | 22528744 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Some of the induced pluripotent stem cell (iPS cell)-inducing factors have been reported to be expressed in breast cancer. | 22528804 |
| Malignant neoplasm of lung, Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | The increasing relevance of the cancer stem cell (CSC) hypothesis and the impact of CSC-associated markers in the carcinogenesis of solid tumours may provide potential prognostic implications in lung cancer. | 22529186 |
| Neoplasms | Stem Cell Exhaustion | In this study we tested the prevalence, histoanatomical distribution and tumour biological significance of the Wnt target protein and cancer stem cell marker LGR5 in tumours of the human gastrointestinal tract. | 22530031 |
| Parainfluenza Virus Infections | Stem Cell Exhaustion | Human parainfluenza virus infection after hematopoietic stem cell transplantation: risk factors, management, mortality, and changes over time. | 22531491 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Criteria for good candidate antigens for immunotherapy of acute myeloid leukemia are high expression on leukemic stem cells in the majority of patients with acute myeloid leukemia and low or no expression in vital tissues. | 22532518 |
| Autoimmune Diseases | Stem Cell Exhaustion | Haematopoietic stem cell transplantation (HSCT) in severe autoimmune diseases: analysis of UK outcomes from the British Society of Blood and Marrow Transplantation (BSBMT) data registry 1997-2009. | 22533715 |
| Autoimmune Diseases | Stem Cell Exhaustion | The British Society of Blood and Marrow Transplantation Data Registry was used to analyse outcomes of haematopoietic stem cell transplantation (HSCT) in severe autoimmune diseases (SADs) from 1997 to 2009. | 22533715 |
| Cerebrovascular accident | Stem Cell Exhaustion | Therapeutic effects of human adipose stem cell-conditioned medium on stroke. | 22535477 |
| Cerebrovascular accident | Stem Cell Exhaustion | Stem cell therapy is a promising approach for stroke. | 22535477 |
| Concomitant Medication Submission Domain | Stem Cell Exhaustion | The use of stem cell-conditioned medium (CM) may be a feasible approach to overcome these limitations. | 22535477 |
| Concomitant Medication Submission Domain | Stem Cell Exhaustion | Especially, specific stem cell culture condition and continuous infusion of CM into ischemic brains would have better therapeutic results. | 22535477 |
| Concomitant Medication Submission Domain | Stem Cell Exhaustion | The CM was prepared by culturing human adipose-derived stem cells in a three-dimensional spheroid form to increase the secretion of angiogenic/neuroprotective factors. | 22535477 |
| Multiple Myeloma | Stem Cell Exhaustion | Increment of hematopoietic progenitor cell count as an indicator of efficient autologs stem cell harvest in patients with multiple myeloma. | 22535685 |
| Microalbuminuria, Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Specifically, some differentially expressed proteins were verified by MRM in urine from normoalbuminuric and microalbuminuric patients with type 2 diabetes, wherein alpha-1-antitrypsin, alpha-1-acid glycoprotein 1, and prostate stem cell antigen had excellent AUC values (0.849, 0.873, and 0.825, resp.). | 22536212 |
| Hematopoietic Stem Cell Mobilization | Stem Cell Exhaustion | Plerixafor, when used pre-emptively in addition to chemomobilization, seems to mobilize more primitive CD34(+) stem cells, T lymphocytes, and NK cells. | 22536949 |
| Keratitis caused by infection | Stem Cell Exhaustion | Infectious keratitis in severe limbal stem cell deficiency: characteristics and risk factors. | 22537286 |
| Keratitis caused by infection | Stem Cell Exhaustion | To evaluate the incidence, clinical and microbiological characteristics and risk factors of infectious keratitis in patients with limbal stem cell deficiency (LSCD). | 22537286 |
| Multiple Myeloma | Stem Cell Exhaustion | Impact of MiRSNPs on survival and progression in patients with multiple myeloma undergoing autologous stem cell transplantation. | 22539802 |
| Multiple Myeloma | Stem Cell Exhaustion | One hundred and thirty-seven patients with chemosensitive multiple myeloma (73M/64F) intensified with autologous stem cell transplantation (ASCT) were studied. | 22539802 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | High-dose melphalan (HD-Mel) is considered the current standard of care among the preparative regimens used in autologous peripheral blood stem cell transplantation (SCT) for multiple myeloma (MM), but optimal time and schedule of administration is not defined. | 22540279 |
| Multiple Myeloma | Stem Cell Exhaustion | Effect of time to infusion of autologous stem cells (24 vs. 48 h) after high-dose melphalan in patients with multiple myeloma. | 22540279 |
| Toxic effect | Stem Cell Exhaustion | We retrospectively analyzed outcomes and toxicities of HD-Mel administered on day -2 vs. day -1 before autologous stem cells infusion. | 22540279 |
| Hypernatremia | Stem Cell Exhaustion | Iron overload in allogeneic hematopoietic stem cell transplant recipients. | 22540302 |
| Failure | Stem Cell Exhaustion | Failure in mobilization of peripheral blood (PB) stem cells is a frequent reason for not performing hematopoietic stem cell transplantation (HSCT). | 22540329 |
| Serous | Stem Cell Exhaustion | In addition, a more broadly distributed array of gene alterations has been discovered in the oviduct, manifested as secretory (or stem) cell outgrowths that are increased in frequency as a function of older age and serous cancer status. | 22543918 |
| Multiple Myeloma | Stem Cell Exhaustion | Diagnostic performance of whole-body MRI for the detection of persistent or relapsing disease in multiple myeloma after stem cell transplantation. | 22544292 |
| Multiple Myeloma | Stem Cell Exhaustion | To compare the diagnostic performance of whole-body MRI (WBMRI) with haematological parameters for detecting persistent or relapsing disease in patients with multiple myeloma after stem cell transplantation. | 22544292 |
| Multiple Myeloma | Stem Cell Exhaustion | Sixty-six WBMRI acquisitions were performed in 33 patients with multiple myeloma at two time points after stem cell transplantation. | 22544292 |
| Sarcoma, Myeloid | Stem Cell Exhaustion | WBMRI allows the detection and exact localisation of intra- and extramedullary myeloma manifestations after stem cell transplantation, but shows only moderate agreement with routinely performed laboratory tests for determination of remission. | 22544292 |
| Acute leukemia | Stem Cell Exhaustion | Second allogeneic transplantation for relapsed acute leukemia after initial allogeneic hematopoietic stem cell transplantation. | 22544355 |
| Acute leukemia | Stem Cell Exhaustion | We retrospectively reviewed the medical records of 45 patients with relapsed acute leukemia after initial allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 22544355 |
| Cerebral Hemorrhage | Stem Cell Exhaustion | Human adipose-derived stem cells for the treatment of intracerebral hemorrhage in rats via femoral intravenous injection. | 22544763 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | Initial low-dose valganciclovir as a preemptive therapy is effective for cytomegalovirus infection in allogeneic hematopoietic stem cell transplant recipients. | 22547196 |
| Cytomegalovirus Infections, Communicable Diseases, allogeneic hematopoietic stem cell transplant with purging | Stem Cell Exhaustion | Preemptive therapy for cytomegalovirus (CMV) infection in allogeneic hematopoietic stem cell transplant (HSCT) patients is effective in decreasing the incidence of CMV disease. | 22547196 |
| Arterial Injury | Stem Cell Exhaustion | Aging is associated with dysfunction of endothelial progenitor cells (EPCs), and shear stress has a beneficial impact on EPC function; however, the effects of aging and shear stress on the endothelial repair capacity of EPCs after arterial injury have not been reported. | 22547440 |
| Hodgkin Disease | Stem Cell Exhaustion | Panobinostat in patients with relapsed/refractory Hodgkin's lymphoma after autologous stem-cell transplantation: results of a phase II study. | 22547596 |
| Hodgkin Disease, LIPC gene | Stem Cell Exhaustion | Hodgkin's lymphoma (HL) has no standard of care for patients who are relapsed or refractory to autologous stem-cell transplantation (ASCT). | 22547596 |
| Richters syndrome", Chronic Lymphocytic Leukemia, Chronic leukemia (category) | Stem Cell Exhaustion | Autologous and allogeneic stem-cell transplantation for transformed chronic lymphocytic leukemia (Richter's syndrome): A retrospective analysis from the chronic lymphocytic leukemia subcommittee of the chronic leukemia working party and lymphoma working party of the European Group for Blood and Marrow Transplantation. | 22547610 |
| REG1CP gene | Stem Cell Exhaustion | The aim of this study was to evaluate the outcome after autologous stem-cell transplantation (autoSCT) or allogeneic stem-cell transplantation (alloSCT) in RS. | 22547610 |
| Acute myocardial infarction | Stem Cell Exhaustion | Mobilization of CD34+CXCR4+ stem/progenitor cells and the parameters of left ventricular function and remodeling in 1-year follow-up of patients with acute myocardial infarction. | 22547906 |
| Medulloblastoma | Stem Cell Exhaustion | Recurrent anaplastic medulloblastoma in cerebrospinal fluid after autologous hematopoietic stem cell transplant. | 22550044 |
| Medulloblastoma | Stem Cell Exhaustion | Herein, we report the CSF cytologic features of a case of recurrent anaplastic medulloblastoma in a 17-year-old male patient who had undergone autologous hematopoietic stem cell transplant as a part of the treatment protocol. | 22550044 |
| Carcinoma, Medulloblastoma | Stem Cell Exhaustion | The differential diagnosis of anaplastic medulloblastoma is broader than that of classic medulloblastoma, as it includes metastatic carcinomas and large cell lymphoma, a differential diagnosis especially pertinent in this patient with a history of autologous hematopoietic stem cell transplant. | 22550044 |
| Nontuberculous Mycobacteria | Stem Cell Exhaustion | A 5-year-old female patient underwent stem cell/bone marrow transplant with disseminated NTM. | 22550970 |
| Neoplasms | Stem Cell Exhaustion | Transcript of CD133 in tumor tissue was lower in patients treated with NSAIDs (0.28 +- 0.07 vs. 0.51 +- 0.08; p<0.03) as well as some other stem cell-related transcripts. | 22552364 |
| Malignant tumor of colon | Stem Cell Exhaustion | Our results show that short-term preoperative NSAID treatment downregulates colon cancer tissue expression of Prominin 1/CD133, a stem cell marker indicative of survival prognosis as confirmed. | 22552364 |
| Post-transplant acute limbic encephalitis | Stem Cell Exhaustion | Human herpesvirus 6 (HHV6) is the major cause of posttransplant acute limbic encephalitis (PALE) in immunosuppressed patients following hematopoietic stem cell transplant. | 22554258 |
| Adult Glioblastoma | Stem Cell Exhaustion | Human mesenchymal stem cells exploit the immune response mediating chemokines to impact the phenotype of glioblastoma. | 22554389 |
| Malignant Neoplasms | Stem Cell Exhaustion | Given this, our primary aim was to ascertain immunohistochemical expression of the ABC transporters ABCB5 and ABCF2 and, the stem cell marker, nestin in a spectrum of benign and malignant nevomelanocytic proliferations, including nevi (n=30), in situ (n=31) and invasive (n=24) primary cutaneous melanomas to assess their role in the stepwise development of malignancy. | 22555176 |
| melanoma | Stem Cell Exhaustion | Profiling of ABC transporters ABCB5, ABCF2 and nestin-positive stem cells in nevi, in situ and invasive melanoma. | 22555176 |
| Adult Glioblastoma, Specialty Type - cancer | Stem Cell Exhaustion | Can irradiation of potential cancer stem-cell niche in the subventricular zone influence survival in patients with newly diagnosed glioblastoma? | 22555992 |
| Adult Glioblastoma | Stem Cell Exhaustion | Glioblastoma progenitor or stem cells residing in the stem-cell niche in the subventricular zones (SVZ) can initiate or promote tumorigenesis. | 22555992 |
| Specialty Type - cancer | Stem Cell Exhaustion | Irradiation of potential cancer stem-cell niche in the SVZ may influence survival. | 22555992 |
| Adult Glioblastoma, Specialty Type - cancer | Stem Cell Exhaustion | Irradiation of potential cancer stem-cell niche influences survival outcomes in patients with newly diagnosed glioblastoma. | 22555992 |
| Adenoma, Colorectal Carcinoma | Stem Cell Exhaustion | Associations between markers of colorectal cancer stem cells and adenomas among ethnic groups. | 22562538 |
| Burn injury | Stem Cell Exhaustion | Analysis of attitudes toward the source of progenitor cells in tissue-engineered products for use in burns compared with other disease states. | 22564226 |
| Burn, CTCAE | Stem Cell Exhaustion | The first trials using progenitor cells to improve burn wound healing are beginning. | 22564226 |
| Diabetes, Burn injury, Parkinson Disease | Stem Cell Exhaustion | Levels of acceptance for the use of progenitor cells derived from these sources for treatment across a range of disease states (burns, Parkinson's disease, diabetes, and for cosmetic use) were also assessed. | 22564226 |
| Post-transplant acute limbic encephalitis | Stem Cell Exhaustion | Human herpesvirus-6 (HHV-6) frequently reactivates after allogeneic hematopoietic stem cell transplantation (HSCT); its most severe manifestation is the syndrome of posttransplantation acute limbic encephalitis (HHV-6-PALE). | 22564265 |
| Hodgkin Disease | Stem Cell Exhaustion | The case of a 29-year-old female patient is presented who obtained polychemotherapy and allogenic stem cell transplantation following the diagnosis of classical Hodgkin's disease. | 22564287 |
| Injury of kidney | Stem Cell Exhaustion | Delayed treatment with human umbilical cord blood-derived stem cells attenuates diabetic renal injury. | 22564642 |
| Ewings sarcoma | Stem Cell Exhaustion | Plerixafor plus G-CSF in combination with chemotherapy for stem cell mobilization in a pediatric patient with Ewing's sarcoma. | 22566276 |
| Malignant Neoplasms | Stem Cell Exhaustion | Some malignant tumors in childhood require high-dose chemotherapy with stem cell support to achieve a cure. | 22566276 |
| Ewings sarcoma, Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Based on the experience with lymphoma and myeloma patients in whom peripheral blood-derived stem cell (PBSC) collection following mobilization with G-CSF failed, we successfully employed plerixafor in a 14-year-old female diagnosed with Ewing's sarcoma in early relapse treated with three lines of chemotherapy in whom PBSC could not be mobilized using either G-CSF alone or G-CSF following chemotherapy. | 22566276 |
| Neoplasms | Stem Cell Exhaustion | Plerixafor may be an effective and safe agent for stem cell collection in pediatric patients with solid tumors, although new studies addressed to evaluate its effectiveness and safety are needed. | 22566276 |
| Multiple Myeloma | Stem Cell Exhaustion | Lenalidomide after stem-cell transplantation for multiple myeloma. | 22571201 |
| Multiple Myeloma | Stem Cell Exhaustion | Data are lacking on whether lenalidomide maintenance therapy prolongs the time to disease progression after autologous hematopoietic stem-cell transplantation in patients with multiple myeloma. | 22571201 |
| Toxic effect, Malignant Neoplasms, Multiple Myeloma | Stem Cell Exhaustion | Lenalidomide maintenance therapy, initiated at day 100 after hematopoietic stem-cell transplantation, was associated with more toxicity and second cancers but a significantly longer time to disease progression and significantly improved overall survival among patients with myeloma. | 22571201 |
| Multiple Myeloma | Stem Cell Exhaustion | Lenalidomide maintenance after stem-cell transplantation for multiple myeloma. | 22571202 |
| Multiple Myeloma | Stem Cell Exhaustion | High-dose chemotherapy with autologous stem-cell transplantation is a standard treatment for young patients with multiple myeloma. | 22571202 |
| Cerebrovascular accident | Stem Cell Exhaustion | Societal value of stem cell therapy in stroke--a modeling study. | 22571941 |
| Cerebrovascular accident | Stem Cell Exhaustion | Stem cell therapy (SCT) may promote functional recovery also in stroke patients, thereby improving quality of life and reducing costs. | 22571941 |
| Cerebrovascular accident | Stem Cell Exhaustion | We modeled for age (55, 65, and 75 years), functional status at discharge (mRS 2, 3, and 4), effectiveness of SCT (50 and 25% increase in the probability to improve 1 mRS grade), mode of stem cell administration, risk of recurrent stroke, complications of intervention, and use of immunosuppressive drugs. | 22571941 |
| Cerebrovascular accident | Stem Cell Exhaustion | The application of the health-economic model to Sweden shows that in younger stroke patients with moderate disability, the societal value of SCT given a zero price of stem cells is 166,500 USD. | 22571941 |
| Cerebrovascular accident | Stem Cell Exhaustion | Hence, further research and development in stem cells suitable for stroke therapy could potentially produce great value to society. | 22571941 |
| Hypertension, CTCAE | Stem Cell Exhaustion | An increased number of endothelial progenitor cells (EPCs), which correlated with heme oxygenase-1 gene expression and nitric oxide-mediated vasodilation [flow-mediated dilation (FMD)], has been recently reported by us in Bartter/Gitelman syndromes, rare diseases that represent a human model of endogenous angiotensin (Ang) II type-1 receptor antagonism and depicting an opposite picture of hypertension. | 22573121 |
| Exfoliative dermatitis, Fever, Mantle cell lymphoma | Stem Cell Exhaustion | A 56-year-old patient presented progressive erythroderma and fever occurring after autologous hematopoietic stem-cell transplantation for mantle cell lymphoma. | 22576078 |
| Chronic myeloproliferative disorder | Stem Cell Exhaustion | Allogeneic stem cell transplantation for myeloproliferative neoplasm in blast phase. | 22578777 |
| Hematologic Neoplasms, Immunocompromised Host | Stem Cell Exhaustion | Immunocompromised patients with hematological malignancies and/or recipients of hematopoietic stem cell transplants are constantly exposed to several fungal, bacterial, and viral respiratory pathogens. | 22580034 |
| Specialty Type - cancer, Aggressive course, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Nestin expression reportedly correlates with aggressive growth, metastasis, poor prognosis and presence of cancer stem cells (CSCs) in various tumors. | 22580387 |
| Lymphoma | Stem Cell Exhaustion | Defects in lymphocyte subsets and serological memory persist a median of 10 years after high-dose therapy and autologous progenitor cell rescue for malignant lymphoma. | 22580768 |
| Primary central nervous system lymphoma, Primary intraocular non-Hodgkin malignant lymphoma | Stem Cell Exhaustion | Intensive chemotherapy with thiotepa, busulfan and cyclophosphamide and hematopoietic stem cell rescue in relapsed or refractory primary central nervous system lymphoma and intraocular lymphoma: a retrospective study of 79 cases. | 22581000 |
| Primary central nervous system lymphoma, Primary intraocular non-Hodgkin malignant lymphoma | Stem Cell Exhaustion | We report the results of a large multicenter retrospective analysis of intensive chemotherapy followed by hematopoietic stem cell rescue in immunocompetent adult patients with primary central nervous system lymphoma or intraocular lymphoma after the failure of high-dose methotrexate-based treatment. | 22581000 |
| Unresponsive to Treatment | Stem Cell Exhaustion | The role of intensive chemotherapy followed by hematopoietic stem cell rescue in chemorefractory patients needs to be more accurately defined. | 22581000 |
| Aplasia Cutis Congenita, Adenoid Cystic Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Adenoid cystic carcinoma (ACC) cells with a high level of ALDH1, a known cancer stem cell (CSC) marker, had higher tumorigenic, invasive, and metastatic abilities. | 22581680 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | The CD34+ hematopoetic stem cell has shown significant promise in addressing myocardial ischemia by promoting angiogenesis that helps preserve the functionality of ischemic myocardium. | 22581926 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Infrapatellar fat pad-derived mesenchymal stem cell therapy for knee osteoarthritis. | 22583627 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Twenty five stem cell injections combined with arthroscopic debridement were administered to patients with knee OA. | 22583627 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | This prospective multicenter phase III study compared the efficacy and safety of a triple combination (bortezomib-thalidomide-dexamethasone [VTD]) versus a dual combination (thalidomide-dexamethasone [TD]) in patients with multiple myeloma (MM) progressing or relapsing after autologous stem-cell transplantation (ASCT). | 22585692 |
| Lymphoma, Follicular | Stem Cell Exhaustion | In 2008, we reported favorable 5-year outcomes of nonmyeloablative allogeneic stem cell transplantation after fludarabine, cyclophosphamide, rituximab (FCR) conditioning for relapsed and chemosensitive follicular lymphoma. | 22586182 |
| Colitis, Ischemic | Stem Cell Exhaustion | Adipose-derived stem cells on the healing of ischemic colitis: a therapeutic effect by angiogenesis. | 22588671 |
| Colitis | Stem Cell Exhaustion | We verified the effects of adipose-derived stem cells (ASCs) on ischemia-induced colitis in a rat model. | 22588671 |
| Malignant Neoplasms, Communicable Diseases | Stem Cell Exhaustion | Other factors associated with in-hospital mortality were severity of illness, performance status, hematologic malignancy, stem-cell transplantation, presence of three or more abnormal physiological variables, time from derangement to ICU admission, presence of infection, need for mechanical ventilation and vasopressor, and low PaO(2)/FiO(2) ratio. | 22592633 |
| Impaired, Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Extramedullary (EM) organ impairment in patients with multiple myeloma (MM) is a rare event, occurring mostly during disease relapse after high-dose chemotherapy with autologous or allogeneic stem cell transplantation. | 22593484 |
| Colorectal Carcinoma | Stem Cell Exhaustion | Evaluation of the adenocarcinoma-associated gene AGR2 and the intestinal stem cell marker LGR5 as biomarkers in colorectal cancer. | 22605983 |
| Neoplasms, Cytogenetic Complete Response | Stem Cell Exhaustion | Our findings indicate that the assessment of AGR2 and LGR5 in PB might reflect the presence of circulating tumor cells (CTC) and stem cell like CTC in CRC. | 22605983 |
| Malignant neoplasm of liver | Stem Cell Exhaustion | Gene expression profiling of liver cancer stem cells by RNA-sequencing. | 22606345 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Accumulating evidence supports that tumor growth and cancer relapse are driven by cancer stem cells. | 22606345 |
| Liver carcinoma, Hollings Cancer Center, Malignant neoplasm of liver | Stem Cell Exhaustion | Our previous work has demonstrated the existence of CD90(+) liver cancer stem cells (CSCs) in hepatocellular carcinoma (HCC). | 22606345 |
| Hollings Cancer Center | Stem Cell Exhaustion | The identified genes, such as GPC3 that are distinctly expressed in liver CD90(+)CSCs, may be promising gene candidates for HCC therapy without inducing damages to normal liver stem cells. | 22606345 |
| Cerebral Palsy | Stem Cell Exhaustion | Treatment of one case of cerebral palsy combined with posterior visual pathway injury using autologous bone marrow mesenchymal stem cells. | 22607263 |
| Toxoplasmosis | Stem Cell Exhaustion | The diagnosis of Toxoplasma infection or disease in hematopoietic stem cell transplantation (HSCT) patients is achieved mainly by PCR screening; however screening did not find wide field of use in practice due to costly expenditures of PCR. | 22609887 |
| Toxoplasmosis | Stem Cell Exhaustion | This study aimed to determine patients at high risk of Toxoplasma infection or disease before transplantation by stem cell originated buffy coat PCR and subsequently to screen them. | 22609887 |
| Osteosclerotic Myeloma | Stem Cell Exhaustion | Long-term outcomes after autologous stem cell transplantation for patients with POEMS syndrome (osteosclerotic myeloma): a single-center experience. | 22611150 |
| POEMS Syndrome | Stem Cell Exhaustion | Patients with disseminated POEMS can be treated with high-dose therapy and autologous stem cell transplantation (ASCT). | 22611150 |
| Anemia, Traumatic AND/OR non-traumatic injury | Stem Cell Exhaustion | To evaluate the roles of apoptotic cells in peripheral blood (PB) on multiple organ injury, five patients with hematopoietic stem cell transplantation (HSCT) and one with refractory anemia were examined. | 22612508 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cells (CSCs) have recently been defined as a fraction of tumor cells highly resistant to therapy and subsequently considered to be responsible for tumor recurrence. | 22614016 |
| Specialty Type - cancer | Stem Cell Exhaustion | It was reported that hypoxic conditions were correlated with cancer stem cell generation and HIF-1a acted as a transcription regulator in nuclear HIF-1a expression. | 22614155 |
| Biliary Tract Cancer | Stem Cell Exhaustion | Association of stem cell marker expression pattern and survival in human biliary tract cancer. | 22614781 |
| Thrombomodulin Alfa | Stem Cell Exhaustion | The investigated BTC samples showed a low to moderate and partially significantly different expression pattern of the stem cell markers in vitro, in vivo and in TMA. | 22614781 |
| Thrombomodulin Alfa, Carcinogenesis | Stem Cell Exhaustion | Hierarchical cluster analysis identified subgroups with homogenous expression of stem cell markers significantly differing with respect to cytokeratin expression in xenografts and Ki67 proliferation marker in human TMA, respectively - thus indicating possible heterogeneous carcinogenesis pathways in BTC. | 22614781 |
| Cerebrovascular Disorders | Stem Cell Exhaustion | Circulating mesenchymal stem cells microparticles in patients with cerebrovascular disease. | 22615882 |
| Cerebrovascular accident | Stem Cell Exhaustion | Preclinical and clinical studies have shown that the application of CD105(+) mesenchymal stem cells (MSCs) is feasible and may lead to recovery after stroke. | 22615882 |
| neurological complication | Stem Cell Exhaustion | * Brain imaging frequently demonstrates neurological complications following haematopoietic stem cell transplantation. | 22618523 |
| Brain Injuries | Stem Cell Exhaustion | Human umbilical cord blood mononuclear cells (hUCB-MNCs) are a rich source of various stem cells that could be of interest in repairing perinatal brain damage. | 22621245 |
| Acute Coronary Syndrome | Stem Cell Exhaustion | Impact of a cardiac rehabilitation program and inflammatory state on endothelial progenitor cells in acute coronary syndrome patients. | 22626841 |
| GDC AJCC Clinical Stage Terminology, Acute Coronary Syndrome | Stem Cell Exhaustion | Among the benefits of a cardiac rehabilitation (CR) program for patients after an acute coronary syndrome (ACS) is the mobilization of endothelial progenitor cells (EPCs). | 22626841 |
| Myeloid neoplasm | Stem Cell Exhaustion | Phase II study of dose-modified busulfan by real-time targeting in allogeneic hematopoietic stem cell transplantation for myeloid malignancy. | 22631696 |
| physiopathological, Atherosclerosis | Stem Cell Exhaustion | Since risk factors for atherosclerosis accelerate endothelial senescence and impair angiogenesis, we examined the role of Lp(a) in dysfunction and senescence of endothelial progenitor cells (EPC) and endothelial cells. | 22634007 |
| Herpesviridae | Stem Cell Exhaustion | Successful clearance of cutaneous acyclovir-resistant, foscarnet-refractory herpes virus lesions with topical cidofovir in an allogeneic hematopoietic stem cell transplant patient. | 22635417 |
| Herpes Simplex Infections, Ulcer | Stem Cell Exhaustion | Here, we present a case of a successful clearance of a perianal acyclovir resistant and foscarnet refractory herpes simplex virus (HSV1) ulcer in a 34 year-old woman who had undergone allogeneic hematopoietic stem cell transplantation. | 22635417 |
| Colorectal Carcinoma | Stem Cell Exhaustion | In situ validation of an intestinal stem cell signature in colorectal cancer. | 22637696 |
| Adenoma | Stem Cell Exhaustion | Wnt/Tcf, Lgr5, Ascl2 and/or Bmi1 signalling is believed to define the mouse intestinal stem cell niche(s) from which adenomas arise. | 22637696 |
| Colorectal Carcinoma | Stem Cell Exhaustion | The aim of this study was to determine the relevance of these putative intestinal stem cell markers to human colorectal cancer. | 22637696 |
| Aggressive behavior, Specialty Type - cancer | Stem Cell Exhaustion | In this large series, Lgr5 expression is not associated with increased tumour aggressiveness, as might be expected from a cancer stem cell marker. | 22637696 |
| Colorectal Carcinoma | Stem Cell Exhaustion | These data suggest that 74-85% of colorectal cancers express a Lgr5/Ascl2 associated signature and support the hypothesis that they derive from Lgr5(+)/Ascl2(+) crypt stem cells, not Bmi1(+) stem cells. | 22637696 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Allogeneic haematopoietic stem cell transplantation for chronic lymphocytic leukaemia: outcome in a 20-year cohort. | 22640008 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | The curative potential of allogeneic haematopoietic stem cell transplant (allo HSCT) in chronic lymphocytic leukaemia CLL is established, with a demonstrated role for graft-versus-leukaemia and less certainty for other factors in determining outcome. | 22640008 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Nordic MCL2 trial update: six-year follow-up after intensive immunochemotherapy for untreated mantle cell lymphoma followed by BEAM or BEAC + autologous stem-cell support: still very long survival but late relapses do occur. | 22640180 |
| Lymphoma | Stem Cell Exhaustion | In 2008 we reported the early - based on the median observation time of 4 years - results of the Nordic Lymphoma Group MCL2 study of frontline intensive induction immunochemotherapy and autologous stem cell transplantation (ASCT), with more than 60% event-free survival at 5 years, and no subsequent relapses reported. | 22640180 |
| Chronic Kidney Diseases, Chronic Kidney Disease, CTCAE | Stem Cell Exhaustion | Stem cell (SC) therapy for chronic kidney disease (CKD) is urgently needed. | 22640266 |
| Chronic Kidney Diseases | Stem Cell Exhaustion | Mesenchymal stem cells therapy is a potential therapeutic modality for early phases of CKD. | 22640266 |
| Ischemic stroke | Stem Cell Exhaustion | Increased levels of circulating endothelial progenitor cells in patients with ischaemic stroke treated with statins during acute phase. | 22640405 |
| Ischemic stroke | Stem Cell Exhaustion | Endothelial progenitor cells (EPCs) have been suggested to be a therapeutic option in ischaemic stroke. | 22640405 |
| Acute myocardial infarction | Stem Cell Exhaustion | The early- to mid-term impact of bone-marrow-derived stem cells (BMC) on diastolic function and exercise capacity after acute myocardial infarction (AMI) remains controversial. | 22640927 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Comparison of outcomes after allogeneic hematopoietic stem cell transplantation in patients with follicular lymphoma, diffuse large B-cell lymphoma associated with follicular lymphoma, or de novo diffuse large B-cell lymphoma. | 22641292 |
| Lymphoma, Follicular, Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | The outcome after allogeneic hematopoietic stem cell transplantation (allo-HCT) for diffuse large B-cell lymphoma (DLBCL) associated with follicular lymphoma (FL), which includes DLBCL with pre- or co-existing FL, remains controversial, and few previous reports have compared the outcomes after allo-HCT for FL, DLBCL associated with FL, and de novo DLBCL. | 22641292 |
| Hemorrhagic cystitis | Stem Cell Exhaustion | Low incidence of adenovirus hemorrhagic cystitis following autologous hematopoietic stem cell transplantation in the rituximab era. | 22641349 |
| Osteoporotic Fractures | Stem Cell Exhaustion | To determine whether estrogen regulates mesenchymal stem cell (MSC) activity in bone marrow from osteoporotic postmenopausal women. | 22642912 |
| Muscle satellite cell | Stem Cell Exhaustion | Can a young muscle's stem cell secretome prolong our lives? | 22643017 |
| Progeria | Stem Cell Exhaustion | A recent provocative study on muscle stem cells, in a mouse model of human progeria, proposes a mechanism that might provide answers to these fundamental ageing questions. | 22643017 |
| Malignant Neoplasms | Stem Cell Exhaustion | High-dose infusional gemcitabine combined with busulfan and melphalan with autologous stem-cell transplantation in patients with refractory lymphoid malignancies. | 22643322 |
| Graft-vs-Host Disease, Acute GVH disease, Infection | Stem Cell Exhaustion | Infections and acute graft-versus-host disease (GvHD) represent major complications of allogeneic stem-cell transplantation (SCT). | 22643330 |
| Chronic heart failure | Stem Cell Exhaustion | Positive effect of eplerenone treatment on endothelial progenitor cells in patients with chronic heart failure. | 22645059 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Survivin is highly expressed in CD34(+)38(-) leukemic stem/progenitor cells and predicts poor clinical outcomes in AML. | 22645176 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | To better understand its role in acute myeloid leukemia (AML), we profiled survivin expression in samples obtained from 511 newly diagnosed AML patients and in CD34(+)38(-) AML stem/progenitor cells using a validated reverse-phase protein array; we correlated its levels with clinical outcomes and with levels of other proteins in the same sample set. | 22645176 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Importantly, survivin levels were significantly higher in CD34(+)38(-) AML stem/progenitor cells than in bulk blasts and total CD34(+) AML cells (P < .05). | 22645176 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | These results suggest that survivin is a prognostic biomarker in AML and that survivin, which is overexpressed in AML stem/progenitor cells, remains a potentially important target for leukemia therapy. | 22645176 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | [Quality of life in patients with coronary artery disease after stem cell therapy]. | 22645909 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Among them, 65 had hematologic malignancies (including 14 hematopoietic stem cell transplant recipients), 22 had iatrogenic immunosuppression, and 13 had solid malignancies. | 22647492 |
| Endometrial Carcinoma, Endometriosis | Stem Cell Exhaustion | These results demonstrate an increased expression of IPO13 in endometriosis and endometrial carcinoma, which could be involved in the pathogenesis of endometriosis and endometrial carcinoma; IPO13 can serve as an endometrial progenitor/stem cell marker. | 22648251 |
| Carcinogenesis | Stem Cell Exhaustion | Some authors have found that p53 has a pivotal role in driving the maturation of myeloid stem cells and p53 is, also, involved in colon carcinogenesis. | 22648549 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Type 2 diabetes mellitus is associated with an imbalance in circulating endothelial and smooth muscle progenitor cell numbers. | 22648662 |
| diabetic | Stem Cell Exhaustion | The CAC/SMPC ratio of in vitro cultured progenitor cells was reduced 2.3-fold in samples from diabetic patients (p < 0.001). | 22648662 |
| Renal Cell Carcinoma | Stem Cell Exhaustion | Stem cell markers aldehyde dehydrogenase type 1 and nestin expressions in renal cell cancer. | 22649953 |
| Renal Cell Carcinoma Pathway, Refractory Cytopenia of Childhood | Stem Cell Exhaustion | To identify stem cell markers aldehyde dehydrogenase type 1 (ALDH-1) and nestin expression in renal cell carcinoma (RCC). | 22649953 |
| Secondary Neoplasm, Refractory Cytopenia of Childhood | Stem Cell Exhaustion | There is a need to perform more studies about stem cell markers in RCC with more patients and in these future studies lymph node metastasis, distant organ metastasis and survival rates should be included. | 22649953 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Mobilized peripheral blood stem cells compared with bone marrow from HLA-identical siblings for reduced-intensity conditioning transplantation in acute myeloid leukemia in complete remission: a retrospective analysis from the Acute Leukemia Working Party of EBMT. | 22650267 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We used the European Group for Blood and Marrow Transplantation (EBMT) ALWP data to compare the outcome of mobilized peripheral blood stem cells (PBSC) (n = 1430) vs. bone marrow (BM) (n = 107) for acute myelogenous leukemia (AML) patients with complete remission that underwent RIC-alloSCT from compatible sibling donors. | 22650267 |
| palladium | Stem Cell Exhaustion | substantia nigra, "SN") and are able to differentiate into both glia and neurons, but only under particular growth conditions including co-culturing with embryonic stem cell-derived neural precursors ("ESNPs"); this suggests that PD multipotent neural stem/progenitor cells do reside within the SN and other areas, but by themselves appear to lack key factors required for neuronal differentiation. | 22652067 |
| Parkinsonian Disorders | Stem Cell Exhaustion | Neurogenic potential of progenitor cells isolated from postmortem human Parkinsonian brains. | 22652067 |
| palladium, Parkinson Disease | Stem Cell Exhaustion | The success of cellular therapies for Parkinson's disease (PD) will depend not only on a conducive growth environment in vivo, but also on the ex vivo amplification and targeted neural differentiation of stem/progenitor cells. | 22652067 |
| Unknown (origin) (qualifier value) | Stem Cell Exhaustion | Here, we demonstrate the in vitro proliferative and differentiation potential of stem/progenitor cells, adult human neural progenitor cells ("AHNPs") isolated from idiopathic PD postmortem tissue samples and, to a lesser extent, discarded deep brain stimulation electrodes. | 22652067 |
| Neoplasms | Stem Cell Exhaustion | The cell surface marker CD133 has been proposed as a brain tumor stem cell marker. | 22652175 |
| Neoplasms | Stem Cell Exhaustion | A distinct subpopulation within CD133 positive brain tumor cells shares characteristics with endothelial progenitor cells. | 22652175 |
| Neoplasms | Stem Cell Exhaustion | Our data suggest the presence of a distinct subpopulation of CD133(+) cells isolated from human brain tumors, with characteristics of endothelial progenitor cells (EPCs). | 22652175 |
| Neoplasms | Stem Cell Exhaustion | Importantly, by analyzing transformed cells generated in vitro and by characterizing novel transgenic mouse models, we further demonstrate that cooperation between an EMT inducer and an active form of RAS is sufficient to trigger transformation of mammary epithelial cells into malignant cells exhibiting all the characteristic features of claudin-low tumors, including low expression of tight and adherens junction genes, EMT traits, and stem cell-like characteristics. | 22654675 |
| COL4A2 wt Allele, Cerebral Hemorrhage | Stem Cell Exhaustion | This study was designed to assess the clinical effect of bone marrow mononuclear cells including mesenchymal stem cell (MSCs) in patients with intracerebral hemorrhage (ICH). | 22657095 |
| Cytomegalovirus viremia, Cytomegalovirus Retinitis | Stem Cell Exhaustion | Risk factors for cytomegalovirus retinitis in patients with cytomegalovirus viremia after hematopoietic stem cell transplantation. | 22657564 |
| Retinitis, Persistent CMV viremia | Stem Cell Exhaustion | To evaluate the risk factors for cytomegalovirus (CMV) retinitis in patients with CMV viremia after hematopoietic stem cell transplantation (HSCT). | 22657564 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | We examined the steady state peripheral blood CD34+ cell count to predict ability to mobilize adequate hematopoietic progenitor cells in 63 myeloma and lymphoma patients. | 22658279 |
| Anemia, Sickle Cell | Stem Cell Exhaustion | Stem cell transplant for children with sickle cell anemia: parent and patient interest. | 22659467 |
| Anemia, Sickle Cell, Renal carnitine transport defect | Stem Cell Exhaustion | We describe adolescents' and parents' interest in hematopoietic stem cell transplant (HSCT) as a cure for sickle cell disease (SCD) and factors associated with increased interest. | 22659467 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Cytogenetic assays demonstrated additional chromosome abnormalities (ACAs): chromosome 8 trisomy in a Ph-negative clone during the IMA treatment (in 1 case) and der(9q) in Ph-positive clone (in 2 cases); in patients receiving first-line IMA only chromosome 8 trisomy was observed which was associated with myelodysplastic syndrome - this was the only case where hematopoietic stem cell transplantation (HSCT) was performed. | 22660209 |
| Hematologic Neoplasms, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Since the involvement of stem cells is considered to be important in hematological malignancies as well as normal hematopoiesis, we examined the expression of newly defined HSC factors including HOXB4, TCFEC, HMGB-1, FOS, and SPI-1 in the bone marrow (BM) from de novo acute myeloid leukemia (AML) patients. | 22664110 |
| Atherosclerosis, Myocardial Ischemia, Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Decreased endothelial progenitor cells and increased serum glycated albumin are independently correlated with plaque-forming carotid artery atherosclerosis in type 2 diabetes patients without documented ischemic disease. | 22664650 |
| Plaque, Atherosclerotic, Myocardial Ischemia, Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | The aim of the present study was to investigate the serum levels of endothelial progenitor cells (EPCs) in type 2 diabetic patients without documented ischemic disease and the association between EPCs and atherosclerotic plaque formation in the carotid artery. | 22664650 |
| Abnormality of mitochondrial metabolism | Stem Cell Exhaustion | Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype. | 22665934 |
| Chronic graft-versus-host disease | Stem Cell Exhaustion | CD4+CD25highCD127low regulatory T cells in peripheral blood are not an independent factor for chronic graft-versus-host disease after allogeneic stem cell transplantation. | 22666141 |
| Multiple Myeloma | Stem Cell Exhaustion | Tandem autologous stem cell transplantation in multiple myeloma after high-dose chemotherapy with two separate collections: single institution experience. | 22668021 |
| Toxic effect | Stem Cell Exhaustion | The objective of this analysis was to assess the feasibility and toxicity of tandem autologous stem cell transplantation (T-ASCT) when stem cells were harvested before first and before second transplantation separately. | 22668021 |
| Toxic effect | Stem Cell Exhaustion | In conclusion, tandem transplantation with two separate stem cell harvests, performed separately before the each transplantation, is feasible in majority of patients with acceptable toxicity. | 22668021 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Flow cytometric quantification and immunophenotyping of leukemic stem cells in acute myeloid leukemia. | 22669506 |
| Leukemic Blast Count, Leukemia, Myelocytic, Acute, Pounds | Stem Cell Exhaustion | Leukemic stem cells (LSCs) are root of clonal growth in acute myeloid leukemia (AML) and responsible for the propagation of leukemic blasts (LBs). | 22669506 |
| Pounds | Stem Cell Exhaustion | LSCs are considered as CD34 + CD38- population among LBs and often express as CD123, CD44, or CD184, which are rarely expressed on normal hematopoietic stem cells and could be the potential therapeutic targets. | 22669506 |
| melanoma, Neoplasms | Stem Cell Exhaustion | It has been suggested recently that stem cell marker expression of jumonji AT-rich interactive domain 1B (JARID1B) is required for continuous tumor growth and maintenance in human cutaneous melanoma cells. | 22669717 |
| Uveal melanoma, Specialty Type - cancer | Stem Cell Exhaustion | The aim of this study is to determine whether JARID1B is also expressed in uveal melanoma (UM) and whether JARID1B marks an expanded cancer stem cell pool in poor prognosis UM. | 22669717 |
| BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 20 | Stem Cell Exhaustion | Since obesity impairs wound healing and bone marrow (BM)-derived vasculogenic progenitor cells (PCs) are important for tissue repair, we hypothesize that obesity-impaired wound healing is due, in part, to impaired PC mobilization, trafficking, and function. | 22672117 |
| Specialty Type - cancer, Secondary Neoplasm, Squamous cell carcinoma | Stem Cell Exhaustion | Topoisomerase expression in oral squamous cell carcinoma: relationship with cancer stem cells profiles and lymph node metastasis. | 22672768 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | The relationship between predictive proteins and tumors presenting cancer stem cells (CSCs) profiles in oral tumors is still poorly understood. | 22672768 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | A pilot randomized controlled trial of an oral care intervention to reduce mucositis severity in stem cell transplant patients. | 22672917 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | Oral mucositis remains a significant problem in autologous stem cell transplantation (ASCT). | 22672917 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | CD133 has been suggested to be a cancer stem cell (CSC) marker in various types of cancers. | 22674531 |
| Kidney Diseases | Stem Cell Exhaustion | Enhanced propagation of adult human renal epithelial progenitor cells to improve cell sourcing for tissue-engineered therapeutic devices for renal diseases. | 22674876 |
| Toxic effect | Stem Cell Exhaustion | Treatment in both phases continued until disease progression, stem-cell transplantation, or severe toxicity. | 22677155 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | Reduced intensity allogeneic hematopoietic stem cell transplantation for MDS using tacrolimus/sirolimus-based GVHD prophylaxis. | 22677229 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | We report a consecutive series of 59 patients with MDS who underwent reduced-intensity hematopoietic stem cell transplantation (RI-HSCT) with fludarabine/melphalan conditioning and tacrolimus/sirolimus-based GVHD prophylaxis. | 22677229 |
| Neurodegenerative Disorders | Stem Cell Exhaustion | Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis. | 22681703 |
| Bone marrow hypocellularity, FANCA wt Allele | Stem Cell Exhaustion | FA patients undergo progressive bone marrow failure (BMF) during childhood, which frequently requires allogeneic hematopoietic stem cell transplantation. | 22683204 |
| Bone marrow hypocellularity, Fanconi Anemia | Stem Cell Exhaustion | Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells. | 22683204 |
| Multiple Myeloma | Stem Cell Exhaustion | Preapheresis peripheral blood (PB) CD34(+) cell count is a strong predictor of hematopoietic stem cell (HSC) mobilization and is routinely used to optimize the timing, cost, and success of HSC collection in patients with multiple myeloma. | 22683613 |
| Failure | Stem Cell Exhaustion | However, a uniform PB CD34(+) cell count that predicts mobilization failure has not been defined, resulting in the development of institute-specific algorithms for mobilization, particularly regarding the decision of when to use the novel stem cell mobilization agent plerixafor. | 22683613 |
| Multiple Myeloma | Stem Cell Exhaustion | Plerixafor plus granulocyte colony-stimulating factor versus placebo plus granulocyte colony-stimulating factor for mobilization of CD34(+) hematopoietic stem cells in patients with multiple myeloma and low peripheral blood CD34(+) cell count: results of a subset analysis of a randomized trial. | 22683613 |
| Neoplasms | Stem Cell Exhaustion | Bone marrow (BM)-derived endothelial progenitor cells (EPCs) play a critical role in tumor vasculogenesis because they provide both instructive (release of pro-angiogenic cytokines, such as VEGF) and structural (vessel incorporation and stabilization) functions. | 22683631 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Cardiomyocytes (CMs) and mesenchymal stem cells (MSCs) are important cell types for cardiac repair post myocardial infarction. | 22683798 |
| leukemia, Secondary Neoplasm | Stem Cell Exhaustion | Leukemia seems to depend on a small population of "leukemia stem cells (LSCs)" for its growth and metastasis. | 22684553 |
| Hepatocarcinogenesis | Stem Cell Exhaustion | The analogy to ageing-related changes is suggestive of premature ageing of stem cells in non-cirrhotic hepatocellular carcinoma-bearing liver as an early step to hepatocarcinogenesis. | 22685011 |
| Allogeneic Hematopoietic Stem Cell Transplantation, Pneumonia, Interstitial | Stem Cell Exhaustion | [Successful treatment with prednisolone for air-leak syndrome following interstitial pneumonia after allogeneic hematopoietic stem cell transplantation]. | 22687980 |
| Varicella Zoster Virus Infection | Stem Cell Exhaustion | [Immune-mediated encephalomyelitis following varicella-zoster virus infection after allogeneic stem cell transplantation]. | 22687982 |
| Renal dysfunction | Stem Cell Exhaustion | In our facility, three patients developed tacrolimus (TAC)-induced renal dysfunction after allogeneic hemopoietic stem cell transplantation, although trough levels of TAC were within therapeutic ranges. | 22687983 |
| Meningioma, Adult Glioblastoma | Stem Cell Exhaustion | Circulating progenitor cells: a comparison of patients with glioblastoma or meningioma. | 22688590 |
| Heterogeneity | Stem Cell Exhaustion | SPT shows multi-heterogeneity, which is caused by the disorder in the development of pancreatic stem cell. | 22688864 |
| Multiple Myeloma | Stem Cell Exhaustion | Changes in magnetic resonance imaging before and after autologous stem cell transplantation correlate with response and survival in multiple myeloma. | 22689673 |
| Multiple Myeloma | Stem Cell Exhaustion | In the current study, we compared treatment response in 100 myeloma patients with changes in infiltration patterns in whole body magnetic resonance imaging before and after autologous stem cell transplantation. | 22689673 |
| T-cell leukemia-lymphoma gene | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia-lymphoma with special emphasis on preconditioning regimen: a nationwide retrospective study. | 22689862 |
| TRPV6 wt Allele | Stem Cell Exhaustion | We performed a nationwide retrospective study of allogeneic hematopoietic stem cell transplantation (HSCT) for ATL in Japan, with special emphasis on the effects of the preconditioning regimen. | 22689862 |
| Intimal sarcoma | Stem Cell Exhaustion | RUNX-1 and CD44 as markers of resident stem cell derivation in undifferentiated intimal sarcoma of pulmonary artery. | 22690828 |
| Neoplasms | Stem Cell Exhaustion | These findings, together with the negativity for mature endothelial and smooth muscle markers, raise the question of whether this neoplasm may derive from a vessel wall-resident stem cell, such as the haemangioblast or an embryonic-like stem cell. | 22690828 |
| Pulmonary Sclerosing Hemangioma | Stem Cell Exhaustion | Expression and significance of stem cell markers in pulmonary sclerosing haemangioma. | 22691172 |
| Herpes encephalitis, Memory Loss, Drowsiness | Stem Cell Exhaustion | A 50-year-old woman developed a human herpes virus 6 limbic encephalitis characterized by memory loss and somnolence, 3 weeks after a cord blood-derived stem cell transplantation. | 22691524 |
| Neoplasms, Specialty Type - cancer, leukemia | Stem Cell Exhaustion | Various aspects were highlighted, including the identification of effective therapeutic targets, the role of cellular senescence in tumor development and therapy, chromosome translocations in leukemias and solid tumors, mechanisms underlying fragile sites and chromosome instability, tumor-associated 'omics' landscapes, genetic and epidemiologic risk factors, the role of tissue and cancer stem cells, angiogenesis and the tumor micro-environment, and the epigenetics of cancer. | 22692945 |
| Enterococcus | Stem Cell Exhaustion | Enterococcal bacteremia is associated with increased risk of mortality in recipients of allogeneic hematopoietic stem cell transplantation. | 22693346 |
| Kidney Diseases | Stem Cell Exhaustion | Mesenchymal stem cells derived from adipose tissue are not affected by renal disease. | 22695328 |
| Kidney Diseases | Stem Cell Exhaustion | Mesenchymal stem cells are a potential therapeutic agent in renal disease and kidney transplantation. | 22695328 |
| Kidney Diseases | Stem Cell Exhaustion | Autologous cell use in kidney transplantation is preferred to avoid anti-HLA reactivity; however, the influence of renal disease on mesenchymal stem cells is unknown. | 22695328 |
| Kidney Diseases, Functional Laterality | Stem Cell Exhaustion | Thus, mesenchymal stem cells of patients with renal disease have similar characteristics and functionality as those from healthy controls. | 22695328 |
| Graft-vs-Host Disease, leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European group for blood and marrow transplantation. | 22699419 |
| Graft-vs-Host Disease, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | This report investigated the impact of graft-versus-host disease (GVHD) on transplantation outcomes in 1859 acute myeloid leukemia patients given allogeneic peripheral blood stem cells after reduced-intensity conditioning (RIC allo-SCT). | 22699419 |
| Granulocytic Sarcoma, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation for adult AML patients with granulocytic sarcoma. | 22699453 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Therefore, the aim of this study was to assess the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for the management of AML with GS. | 22699453 |
| Stable chronic Graft vs Host Disease | Stem Cell Exhaustion | Chronic graft-vs.-host disease (cGVHD) is a complication of allogeneic hematopoietic stem cell transplantation (alloHSCT). | 22699667 |
| Toxic effect | Stem Cell Exhaustion | NCA (131)I-MIBG with autologous peripheral blood stem cell transplantation is feasible at 666 MBq/kg without significant nonhematologic toxicity and with promising activity. | 22700000 |
| Central neuroblastoma | Stem Cell Exhaustion | Eligible patients were 1-30 y old with resistant neuroblastoma, (131)I-MIBG uptake, and cryopreserved hematopoietic stem cells. | 22700000 |
| Myelosuppression | Stem Cell Exhaustion | Autologous hematopoietic stem cells were infused 14 d after therapy to abrogate prolonged myelosuppression. | 22700000 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | To investigate the association of the CD44+/CD24- cancer stem cell (CSC) ratio with clinicopathologic features and its prognostic value in breast cancer. | 22702496 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Toll-like receptor gene polymorphisms confer susceptibility to graft-versus-host disease in allogenic hematopoietic stem cell transplantation. | 22703024 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease (GvHD) is a major complication in hematopoietic stem cell transplantation (HSCT). | 22703024 |
| Shock, Cardiogenic | Stem Cell Exhaustion | Bone marrow (BM)-derived mononuclear cell (MNC) preparations are increasingly used in experimental studies exploring the potential effect of progenitor cell-derived therapies in cardiocirculatory diseases. | 22703161 |
| Structure of vastus lateralis muscle | Stem Cell Exhaustion | Baseline and end-protocol evaluations included i) one incremental cardiopulmonary exercise test with near infrared spectroscopy analysis of peak deoxygenated hemoglobin+myoglobin concentration changes (D[deoxy(Hb+Mb)]) in vastus lateralis muscle, ii) 8 light-to-moderate-intensity constant-work-rate exercise tests for VO2 on-kinetics phase I duration, phase II t, and mean response time (MRT) assessment, and iii) circulating endothelial progenitor cell (EPC) measurement. | 22703939 |
| Cholestasis, Extrahepatic | Stem Cell Exhaustion | We report the clinical transplantation of a deceased donor iliac vein graft repopulated with recipient autologous stem cells in a patient with extrahepatic portal vein obstruction. | 22704550 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation for intermediate cytogenetic risk AML in first CR. | 22705800 |
| Multiple Myeloma | Stem Cell Exhaustion | Serum free light chains and oligoclonal bands in patients with multiple myeloma and autologous stem cell transplantation. | 22706252 |
| Kidney Failure | Stem Cell Exhaustion | She underwent rituximab monotherapy and finally allogeneic hematopoietic stem cell transplantation in October 2010, but died of renal failure in February 2011. | 22706530 |
| Hematologic Neoplasms, Hepatitis B | Stem Cell Exhaustion | It has recently been reported that hepatitis B virus (HBV) reactivation in patients with hepatitis B surface antigen (HBsAg)-negative lymphoma during or after cytotoxic therapy occurs after the use of rituximab and stem cell transplantation for hematologic malignancies. | 22706534 |
| EYA1 wt Allele | Stem Cell Exhaustion | This is the first reported case of HBV reactivation in an HBsAg-negative myeloma patient treated with bortezomib (BOR) as salvage therapy and not stem cell transplantation. | 22706534 |
| Specialty Type - cancer | Stem Cell Exhaustion | CD44 is well known to be one of the cancer stem cell markers and is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion, and cell migration. | 22706704 |
| Amyloidosis | Stem Cell Exhaustion | Ten-year survival after autologous stem cell transplantation for immunoglobulin light chain amyloidosis. | 22707405 |
| Amyloidosis | Stem Cell Exhaustion | The current study was conducted to determine characteristics distinguishing the 10-year survivor group in patients with systemic immunoglobulin light chain (AL) amyloidosis who underwent autologous stem cell transplantation (SCT). | 22707405 |
| Bronchiolitis, Pleuropericarditis, Pneumonia, Interstitial | Stem Cell Exhaustion | Pleuropericarditis, obliterative bronchiolitis and lymphocytic interstitial pneumonitis after allogeneic haematopoietic stem cell transplantation. | 22707568 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disorder of elderly people. | 22709732 |
| Acute GVH disease | Stem Cell Exhaustion | Anti-thymocyte globulin (thymoglobulin), tacrolimus, and sirolimus as acute graft-versus-host disease prophylaxis for unrelated hematopoietic stem cell transplantation. | 22710143 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Acute graft-versus-host disease (aGVHD) is a major cause of morbidity and mortality in patients undergoing unrelated hematopoietic stem cell transplantation. | 22710143 |
| Graft-vs-Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | These results suggest that the combination of Thymoglobulin, tacrolimus, and sirolimus in patients undergoing unrelated hematopoietic stem cell transplantation is well tolerated and associated with a low incidence and severity of aGVHD and chronic graft-versus-host disease. | 22710143 |
| Esophageal Neoplasms | Stem Cell Exhaustion | Quiescence and attenuated DNA damage response promote survival of esophageal cancer stem cells. | 22711554 |
| Cessation of life, Specialty Type - cancer | Stem Cell Exhaustion | Accumulating evidence indicates cancer stem cells (CSCs) possess the capability to resist DNA-damage induced cell death, whereas the mechanism is largely unknown. | 22711554 |
| Esophageal Neoplasms | Stem Cell Exhaustion | In this study, we isolated esophageal cancer stem cells (ECSCs) from esophageal cancer cell line EC9706 by side-population (SP) phenotype through flow cytometry and found that ECSCs preferentially stay quiescent as compared to the non-ECSCs and are more resistant to DNA damage agents. | 22711554 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Underlying disease was acute myeloid leukemia in 45 patients (39%), and 21 (18%) were allogeneic stem cell transplant recipients. | 22712457 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cells are regarded as the origin of tumors that can proliferate, relapse, and metastasize. | 22714588 |
| Specialty Type - cancer | Stem Cell Exhaustion | Nanog, with its capacity to maintain the pluripotency and regulate proliferation and prevent differentiation, is one of the most important core markers of cancer stem cells. | 22714588 |
| Colorectal Carcinoma, Secondary malignant neoplasm of liver | Stem Cell Exhaustion | Stem cell gene Girdin: a potential early liver metastasis predictor of colorectal cancer. | 22714912 |
| Coronary Aneurysm | Stem Cell Exhaustion | Coronary artery aneurysm after implantation of an endothelial progenitor cell capturing stent. | 22718389 |
| Bacteremia, Intestinal Elimination | Stem Cell Exhaustion | Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation. | 22718773 |
| Bacteremia | Stem Cell Exhaustion | Bacteremia is a frequent complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 22718773 |
| Mantle cell lymphoma | Stem Cell Exhaustion | CHOP and DHAP plus rituximab followed by autologous stem cell transplantation in mantle cell lymphoma: a phase 2 study from the Groupe d'Etude des Lymphomes de l'Adulte. | 22718839 |
| Rheumatoid Arthritis | Stem Cell Exhaustion | Intra-articular adipose-derived mesenchymal stem cells from rheumatoid arthritis patients maintain the function of chondrogenic differentiation. | 22718867 |
| Rheumatoid Arthritis, Degenerative polyarthritis | Stem Cell Exhaustion | To evaluate the chondrogenic potential, phenotype and percentage of IA adipose-derived mesenchymal stem cells (ADSCs) from RA patients in comparison with OA patients. | 22718867 |
| Prostate carcinoma | Stem Cell Exhaustion | In this study, we used quantitative real-time-PCR to define miRNA expression patterns in various stem/progenitor cell populations in prostate cancer, including CD44+, CD133+, integrin a2b1+, and side population cells. | 22719071 |
| Prostate carcinoma | Stem Cell Exhaustion | Multiple tumor-suppressive miRNAs were downregulated coordinately in several prostate cancer stem/progenitor cell populations, namely, miR-34a, let-7b, miR-106a, and miR-141, whereas miR-301 and miR-452 were commonly overexpressed. | 22719071 |
| Prostate carcinoma | Stem Cell Exhaustion | Distinct microRNA expression profiles in prostate cancer stem/progenitor cells and tumor-suppressive functions of let-7. | 22719071 |
| Specialty Type - cancer | Stem Cell Exhaustion | MiRNAs regulate cancer cells, but their potential effects on cancer stem/progenitor cells are still being explored. | 22719071 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Myelodysplastic syndromes (MDS) are a heterogenous group of clonal hematopoietic stem cell disorders. | 22722455 |
| Specialty Type - cancer | Stem Cell Exhaustion | We uncover a previously unknown link between the stem cell and oncogenic potential whereby b-catenin regulates Tert expression, and thereby telomere length, which could be critical in human regenerative therapy and cancer. | 22723415 |
| Specialty Type - cancer | Stem Cell Exhaustion | Wnt/b-catenin signaling regulates telomerase in stem cells and cancer cells. | 22723415 |
| Specialty Type - cancer | Stem Cell Exhaustion | Telomerase activity controls telomere length and plays a pivotal role in stem cells, aging, and cancer. | 22723415 |
| Diabetes Mellitus, Insulin-Dependent, Diabetic Ketoacidosis | Stem Cell Exhaustion | Diabetic ketoacidosis at diagnosis influences complete remission after treatment with hematopoietic stem cell transplantation in adolescents with type 1 diabetes. | 22723579 |
| Diabetic Ketoacidosis, diabetic | Stem Cell Exhaustion | To determine if autologous nonmyeloablative hematopoietic stem cell transplantation (AHSCT) was beneficial for type 1 diabetic adolescents with diabetic ketoacidosis (DKA) at diagnosis. | 22723579 |
| Chronic Kidney Disease, CTCAE | Stem Cell Exhaustion | Human embryonic mesenchymal stem cell-derived conditioned medium rescues kidney function in rats with established chronic kidney disease. | 22723882 |
| Dementia | Stem Cell Exhaustion | Genotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tau. | 22723997 |
| Erythroplasia, Lip and Oral Cavity Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Expression of cancer stem cell markers ALDH1 and Bmi1 in oral erythroplakia and the risk of oral cancer. | 22725270 |
| Specialty Type - cancer, S100A4 protein, human | Stem Cell Exhaustion | The objective of this study was to determine the expression of cancer stem cell markers ALDH1 and Bmi1 in OE and their correlation with malignant transformation of OE. | 22725270 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Acute graft versus host disease (aGvHD) is a major cause of early morbidity post-haematopoietic stem cell transplantation with minor histocompatibility antigens being a contributing factor. | 22726315 |
| Adverse Event Associated with Secondary Malignancy | Stem Cell Exhaustion | Secondary malignancy in the oral mucosa is recognized as one of the most serious complications in patients who received allogenic hematopoietic stem cell transplantation (HSCT). | 22726540 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The relapse risk of AML patients undergoing autologous transplantation correlates with the stem cell mobilizing potential. | 22727508 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Autologous stem cell transplantation (ASCT) is widely used to consolidate first remission in AML. | 22727508 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We determined the significance of circulating CD34+ cells at the day of blood stem cell collection in 78 AML patients. | 22727508 |
| Fever, Specialty Type - cancer, Fever of Unknown Origin, Communicable Diseases | Stem Cell Exhaustion | Prospective surveillance of fever of unknown origin (FUO), clinically documented infection and microbiologically documented infection (MDI) was conducted in the haemato-oncology and haematopoietic stem cell transplantation wards in a single cancer centre in Israel. | 22727772 |
| Multiple Myeloma | Stem Cell Exhaustion | Cytomegalovirus reactivation following autologous peripheral blood stem cell transplantation for multiple myeloma in the era of novel chemotherapeutics and tandem transplantation. | 22728249 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | However, few studies have examined CMV reactivation after autologous peripheral blood stem cell transplantation (APBSCT) to treat multiple myeloma (MM), especially in the setting of the newer chemotherapeutic agents and/or 2 sequential APBSCTs (ie, tandem transplantation). | 22728249 |
| Multiple Myeloma | Stem Cell Exhaustion | For this patient, multiple myeloma with high KL-6 was refractory to chemotherapy, suggesting that new treatment strategies, including transplantation of hematopoietic stem cells, are required. | 22728554 |
| Multiple Myeloma | Stem Cell Exhaustion | Thalidomide plus dexamethasone as a maintenance therapy after autologous hematopoietic stem cell transplantation improves progression-free survival in multiple myeloma. | 22730113 |
| Multiple Myeloma | Stem Cell Exhaustion | Despite the good response of stem cell transplant (SCT) in the treatment of multiple myeloma (MM), most patients relapse or do not achieve complete remission, suggesting that additional treatment is needed. | 22730113 |
| Specialty Type - cancer, melphalan/prednisone protocol, Squamous cell carcinoma | Stem Cell Exhaustion | The side population (SP) with cancer stem cell-like properties and the main population (MP) were isolated from human A431 squamous carcinoma cells. | 22732006 |
| Carcinoma | Stem Cell Exhaustion | We postulate that carcinoma stem cells would be intrinsically primed to rapidly repair DNA damage by a high constitutive level of nuclear FGF2. | 22732006 |
| Aspergillosis | Stem Cell Exhaustion | Using the galactomannan antigen assay in the diagnosis of invasive aspergillosis after hematopoietic stem cell transplantation. | 22732810 |
| Infection, Aspergillosis | Stem Cell Exhaustion | Invasive aspergillosis (IA) is the most common life-threatening infections after hematopoietic stem cell transplant (HSCT). | 22732810 |
| Colorectal Carcinoma | Stem Cell Exhaustion | The transmembrane glycoprotein CD133 (cluster of differentiation 133; also known as Prominin or PROM1) has been described as a potential stem cell marker in colorectal cancer and is associated with higher tumorigenic potential and resistance to radiochemotherapy (RCT). | 22736392 |
| Ischemia | Stem Cell Exhaustion | Our data might provide a valuable snapshot at potential progenitor cells after acute ischaemia in vivo, and mapping of these easily accessible cells may influence future cell therapeutic strategies. | 22736676 |
| Gastrointestinal Stromal Tumors | Stem Cell Exhaustion | Stem cell factor-mediated wild-type KIT receptor activation is critical for gastrointestinal stromal tumor cell growth. | 22736916 |
| Gastrointestinal Stromal Tumors | Stem Cell Exhaustion | To clarify the biological role of stem cell factor (SCF)-mediated wild-type KIT receptor activation in gastrointestinal stromal tumor (GIST) growth. | 22736916 |
| Adult Glioblastoma, Fulfill | Stem Cell Exhaustion | The MET oncogene is a functional marker of a glioblastoma stem cell subtype. | 22738909 |
| Neoplasms | Stem Cell Exhaustion | However, the molecular alterations that drive stem cell proliferation in these tumors remain unknown. | 22738909 |
| Adult Glioblastoma, Specialty Type - cancer | Stem Cell Exhaustion | The existence of treatment-resistant cancer stem cells contributes to the aggressive phenotype of glioblastoma. | 22738909 |
| Adult Glioblastoma, Glioblastoma | Stem Cell Exhaustion | Together, our findings suggest that Met is a functional marker of glioblastoma stem cells and a candidate target for identification and therapy of a subset of glioblastomas. | 22738909 |
| Lymphoma | Stem Cell Exhaustion | [Clinical observation of 100 patients with malignant lymphoma treating with different preconditioning regimens followed by autologous hematopoietic stem cell transplantation]. | 22739163 |
| Lymphoma | Stem Cell Exhaustion | This study was designed to compare the curative effect, prognosis and safety of different preconditioning regimens for patients who received autologous hematopoietic stem cell transplantation (AHSCT) for malignant lymphoma (ML). | 22739163 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells (CSC) with several characteristics can lead to therapeutic resistance. | 22739652 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | One of the factors responsible for recurrence is supposed to be cancer stem cells (CSCs) or tumor-initiating cells, which are a population of cancer cells with ability to perpetuate themselves through self-renewal and to generate differentiated cells, thought to be responsible for tumor recurrence. | 22740326 |
| Malignant tumor of colon | Stem Cell Exhaustion | This study globally approach the possible role of tissue-derived stem cells in the initiation of colon cancer and its metastatic process in the liver. | 22740326 |
| Adult Stem Cells | Stem Cell Exhaustion | Genomic instability and persistent DNA damage may cause loss of adult stem cell function. | 22740444 |
| Acquired (qualifier value) | Stem Cell Exhaustion | Humans accumulate microsatellite instability with acquired loss of MLH1 protein in hematopoietic stem and progenitor cells as a function of age. | 22740444 |
| Aspergillosis, Immunocompromised Host, Communicable Diseases | Stem Cell Exhaustion | Invasive aspergillosis (IA) is a life-threatening infection in severely immunocompromised patients, especially those receiving intensive chemotherapy or undergoing haematopoietic stem cell transplantation. | 22740590 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | The expression of SSEA-4 was related to clinico-pathological characteristics, to the expression of the adult stem cell antigens CD117, CD133 and breast cancer resistance protein 1 (BCRP1), and to prognosis. | 22743677 |
| Burn injury | Stem Cell Exhaustion | Reepithelialization from stem cells of hair follicles of dermal graft of the scalp in acute treatment of third-degree burns: first clinical and histologic study. | 22743954 |
| Hair follicle structure | Stem Cell Exhaustion | The purpose of this study was to double scalp harvesting in one procedure and to evaluate the capacity of the dermal layer to spontaneously reepithelialize from hair follicle stem cells. | 22743954 |
| Henoch-Schoenlein Purpura, Milk Allergy, Pyloric Stenosis, chlormadinone acetate, Celiac Disease, Gastrointestinal symptom | Stem Cell Exhaustion | Data of 5 studies with identical methodology to assess GI symptoms in children with celiac disease (CD), cow's milk allergy (CMA), pyloric stenosis (PS), Henoch-Schonlein purpura (HSP), and stem cell transplant (SC) and their healthy siblings were reviewed: a phone questionnaire on GI symptoms and Pediatric Gastrointestinal Symptoms Rome III version questionnaire (QPGS-RIII). | 22744191 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Prospective study of erythropoietin use on quality of life and cost effectiveness in acute myeloid leukemia and allogeneic hematopoietic stem cell transplantation patients. | 22744794 |
| Anemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Despite frequent anemia and multiple transfusions in patients undergoing chemotherapy and allogeneic hematopoietic stem cell transplantation (allo-HSCT) for acute myeloid leukemia , recommendations for use of erythropoiesis-stimulating agents (ESAs) in these populations are still missing. | 22744794 |
| Left Ventricular Function | Stem Cell Exhaustion | The PERFECT trial has been designed as a prospective, randomized, double-blind, placebo controlled, multicenter trial, analyzing the effect of intramyocardial CD 133(+) bone marrow stem cell injection in combination with coronary artery bypass grafting on postoperative left ventricular function. | 22747980 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease is a major complication after allogenic hematopoietic stem cell transplantation. | 22748084 |
| Malignant Peripheral Nerve Sheath Tumor, Myeloproliferative disease | Stem Cell Exhaustion | Myeloproliferative neoplasms (MPNs) result from genetically altered hematopoietic stem cells that retain the capacity for multilineage differentiation. | 22749035 |
| Communicable Diseases | Stem Cell Exhaustion | On univariable analysis, risk factors for reduced linezolid susceptibility included allogeneic hematopoietic stem cell transplant and/or solid organ transplant (odds ratio [OR]: 2.63; 95% confidence interval [CI]: 1.13-6.15; P = 0.025), receipt of immunosuppressive medications (OR: 2.39; 95% CI: 1.08-5.29; P = 0.032) including corticosteroids (OR: 2.40; 95% CI: 1.03-5.58; P = 0.042) and noncorticosteroid immunosuppressives (OR: 2.31; 95% CI: 1.00-5.30; P = 0.049), and receipt of linezolid within 1 year prior to infection (OR: 34.50, 95% CI: 4.60-259.02; P < 0.001). | 22749382 |
| Neutropenia | Stem Cell Exhaustion | Human granulocyte colony-stimulating-factor (G-CSF) is widely used for treatment of neutropenia and to mobilize stem/progenitor cells for bone marrow transplantation. | 22751169 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | To investigate the effects of age and disease on endogenous cardiac progenitor cells, we obtained right atrial and left ventricular epicardial biopsies from patients (n = 22) with chronic ischaemic heart disease and measured doubling time and surface marker expression in explant- and cardiosphere-derived cells (EDCs, CDCs). | 22752803 |
| NPM1 wt Allele | Stem Cell Exhaustion | Because RUNX1 mutations were more common in older patients and almost never coexisted with NPM1 mutations, RUNX1 mutation-associated expression signatures were derived in older, NPM1 wild-type patients and featured upregulation of genes normally expressed in primitive hematopoietic cells and B-cell progenitors, including DNTT, BAALC, BLNK, CD109, RBPMS, and FLT3, and downregulation of promoters of myelopoiesis, including CEBPA and miR-223. | 22753902 |
| Glioblastoma Multiforme Pathway, Neoplasms | Stem Cell Exhaustion | All of the tumor sphere cell populations showed a slower degree of cell proliferation than that of human glioma cells and fetal neural stem cells (NSCs). | 22754374 |
| Multiple Myeloma | Stem Cell Exhaustion | Multiple myeloma is incurable despite the advance of autologous stem cell transplant (ASCT) and novel agents (thalidomide, bortezomib, lenalidomide). | 22757772 |
| Multiple Myeloma | Stem Cell Exhaustion | Phase I trial of bortezomib during maintenance phase after high dose melphalan and autologous stem cell transplantation in patients with multiple myeloma. | 22759762 |
| Lymphoma, Non-Hodgkin, Multiple Myeloma | Stem Cell Exhaustion | Plerixafor as first- and second-line strategies for autologous stem cell mobilization in patients with non-Hodgkin's lymphoma or multiple myeloma. | 22760691 |
| Failure | Stem Cell Exhaustion | To describe the institutional experience of plerixafor plus filgrastim as the initial peripheral blood stem cell (PBSC) mobilization (first-line strategy) and as rescue therapy after failure with filgrastim plus cyclophosphamide (second-line strategy). | 22760691 |
| Hemangioma, Neoplasms | Stem Cell Exhaustion | Urethral hemangiomas are rare and benign tumors, probably originating from a unipotent angioblastic stem cell. | 22760936 |
| Hematopoietic stem cells, Cytopenia | Stem Cell Exhaustion | One third of patients have disease that is refractory to immunosuppression, with persistent, severe cytopenia and a profound deficit in hematopoietic stem cells and progenitor cells. | 22762314 |
| Ductal Carcinoma, Childhood Breast Carcinoma, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Although CD44+/CD24- cells are believed to act as breast cancer stem cells and to be linked to poor prognosis in some patients, the association between these cells and tumor recurrence or metastasis in all or some types of invasive ductal carcinoma is unclear. | 22762532 |
| Myeloproliferative disease, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder characterized by the expansion of a leukemic stem cell (LSC) clone, carrying a Philadelphia translocation, able to overcome the non-malignant hematopoietic stem cells. | 22762548 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Outcome of allogeneic stem cell transplantation in myelodysplastic syndrome patients: prognostic implication of monosomal karyotype. | 22762733 |
| Gastrointestinal Stromal Tumors | Stem Cell Exhaustion | Given that the normal progenitor cell for GIST, the interstitial cell of Cajal, has characteristics similar to those of cells of neuroendocrine origin, we hypothesized that Notch pathway impacts the biology of GIST cells. | 22764137 |
| Cessation of life | Stem Cell Exhaustion | Treatment with mesenchymal stromal cells is a risk factor for pneumonia-related death after allogeneic hematopoietic stem cell transplantation. | 22765507 |
| Cessation of life | Stem Cell Exhaustion | Pneumonia-associated deaths were evaluated in 691 hematopoietic stem cell transplantation (HSCT) patients. | 22765507 |
| FLT3 Internal Tandem Duplication, Leukemia, Myelocytic, Acute, NPM1 wt Allele | Stem Cell Exhaustion | To investigate the role of reduced-intensity allogeneic (RIC-allo) stem cell transplant (SCT) as postremission therapy in adult intermediate-risk patients with acute myelogenous leukemia (AML) with FLT3-ITD or wild-type NPM1 and CEBPA without FLT3-ITD, we conducted a single-center retrospective study between January 2001 and December 2010. | 22766221 |
| Parathyroid Gland Adenocarcinoma | Stem Cell Exhaustion | A subset of over-expressed microRNAs (miRNAs) identified in parathyroid carcinomas (Ca) compared to normal glands belongs to C19MC, a cluster on chromosome 19q13.4 involved in stem cell biology and tumourigenesis. | 22767050 |
| Lymphoma, Follicular, Neoplasms | Stem Cell Exhaustion | A 4-weekly course of rituximab is safe and improves tumor control for patients with minimal residual disease persisting 3 months after autologous hematopoietic stem-cell transplantation: results of a prospective multicenter phase II study in patients with follicular lymphoma. | 22767588 |
| Lymphoma, Follicular | Stem Cell Exhaustion | This study explored the efficacy and safety of rituximab as treatment of clinical or molecular residual disease after autologous stem-cell transplantation (ASCT) in follicular lymphoma (FL). | 22767588 |
| Aggressive course, Specialty Type - cancer | Stem Cell Exhaustion | Podocalyxin-like 1 (PODXL) is a cell-adhesion glycoprotein and stem cell marker that has been associated with an aggressive tumour phenotype and adverse outcome in several cancer types. | 22769594 |
| Diabetes | Stem Cell Exhaustion | (2012) demonstrate that the diabetes medication metformin enhances spatial learning in mice by activating the atypical PKC/CBP pathway in adult neural stem cells. | 22770236 |
| Inferior vena cava structure | Stem Cell Exhaustion | Inferior vena cava (IVC) and renal vein (RV) levels of CD34+/KDR+ progenitor cells, cell adhesion molecules, inflammatory biomarkers, progenitor cell homing signals, and pro-angiogenic factors were measured in EH and ARAS, and their gradient and net release compared with systemic levels in matched normotensive controls (n= 24). | 22771675 |
| Influenza due to Influenza A virus subtype H1N1 | Stem Cell Exhaustion | Outbreak of pandemic 2009 influenza A/H1N1 infection in the hematology ward: fatal clinical outcome of hematopoietic stem cell transplant recipients and emergence of the H275Y neuraminidase mutation. | 22773299 |
| Influenza due to Influenza A virus subtype H1N1, Influenza, Hematologic Neoplasms | Stem Cell Exhaustion | A total of seven hospitalized patients with hematologic tumors, including five recipients of hematopoietic stem cell transplantation (HSCT), successively developed rapid influenza detection test (RIDT)-positive influenza A; four patients had laboratory-confirmed 2009 H1N1 infection. | 22773299 |
| Acute Cerebrovascular Accidents | Stem Cell Exhaustion | CD34/CXCR4 stem cell dynamics in acute stroke patients. | 22773459 |
| Ischemic stroke | Stem Cell Exhaustion | Non-hematopoietic stem cells may be a source of paracrine and structural regeneration for brain damaged by acute ischemic stroke. | 22773459 |
| Acute Cerebrovascular Accidents | Stem Cell Exhaustion | In this study, we investigated correlations of CD34-, CD34/CXCR4-, and CXCR4-positive peripheral blood CD45-negative stem cells with the neurological and functional status of 34 acute stroke patients. | 22773459 |
| Nervous System Physiological Phenomena, Acute Cerebrovascular Accidents | Stem Cell Exhaustion | We report that the number and dynamic changes in levels of non-hematopoietic CD34-, CD34/CXCR4-, and CXCR4-positive stem cells tend to correlate with acute stroke patients' neurologic and functional status. | 22773459 |
| Heart failure | Stem Cell Exhaustion | Testosterone deficiency in male heart failure patients and its effect on endothelial progenitor cells. | 22776027 |
| Fibrosis Assessment | Stem Cell Exhaustion | Adipose-derived stem cells can abrogate chemical-induced liver fibrosis and facilitate recovery of liver function. | 22776464 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | Correlation between the functional impairment of bone marrow-derived circulating progenitor cells and the extend of coronary artery disease. | 22776510 |
| Coronary heart disease | Stem Cell Exhaustion | Bone marrow-derived circulating progenitor cells (BM-CPCs) in patients with coronary heart disease are impaired with respect to number and functional activity. | 22776510 |
| Stem Cell Factor, Hemoglobinuria, CTCAE 3.0 | Stem Cell Exhaustion | [Expression of phosphorylated STAT5 in bone marrow hematopoietic stem cells of patients with paroxysmal nocturnal hemoglobinuria before and after in vitro G-CSF or SCF stimulation]. | 22781567 |
| Multiple Myeloma | Stem Cell Exhaustion | [The efficacy and safety of bortezomib-based induction regimen before autologous hematopoietic stem cell transplantation in patients with multiple myeloma]. | 22781947 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | To investigate the efficacy and safety of bortezomib-based induction regimen followed by autologous hematopoietic stem cell transplantation (ASCT) in patients with multiple myeloma (MM). | 22781947 |
| Peripheral Blood Stem Cells | Stem Cell Exhaustion | Furthermore, engraftment of neutrophil and platelet in patients receiving peripheral blood stem cell transplantation were faster than those receiving bone marrow transplantation. | 22781947 |
| Specialty Type - cancer, S100A4 protein, human, Leukoplakia | Stem Cell Exhaustion | Expression patterns of cancer stem cell markers ALDH1 and CD133 correlate with a high risk of malignant transformation of oral leukoplakia. | 22782852 |
| Lip and Oral Cavity Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | The objective of this study was to examine the expression patterns of cancer stem cell markers ALDH1 and CD133 in samples from patients with OL, and determine their prognostic values for subsequent development of oral cancer. | 22782852 |
| Respiratory Syncytial Virus Infections | Stem Cell Exhaustion | An outbreak of respiratory syncytial virus infection in hematopoietic stem cell transplantation outpatients: good outcome without specific antiviral treatment. | 22783905 |
| Virus Diseases | Stem Cell Exhaustion | Respiratory syncytial virus (RSV) is a common cause of seasonal respiratory viral infection in hematopoietic stem cell transplantations (HSCT) patients. | 22783905 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease (GVHD) is a major barrier to successful allogeneic hematopoietic stem-cell transplantation (HSCT). | 22784116 |
| Ischemic stroke | Stem Cell Exhaustion | Fantasies about stem cell therapy in chronic ischemic stroke patients. | 22784218 |
| nervous system disorder | Stem Cell Exhaustion | Stem cell therapy (SCT) has been proposed for the treatment of neurological disorders. | 22784218 |
| Specialty Type - cancer, Squamous cell carcinoma | Stem Cell Exhaustion | ABCB5 expression and cancer stem cell hypothesis in oral squamous cell carcinoma. | 22784549 |
| SERPINB3 wt Allele, Specialty Type - cancer | Stem Cell Exhaustion | The effectiveness of adjuvant cytostatic chemotherapy for OSCC is frequently restricted due to an inducible cellular mechanism called multidrug resistance (MDR) and a putative cancer stem cell (CSC) compartment in human carcinogenesis expressing multidrug efflux pumps. | 22784549 |
| Specialty Type - cancer | Stem Cell Exhaustion | One of the principal mechanisms for protecting putative cancer stem cells is through the expression of multifunctional efflux transporters from the ABC gene family, like ABCB5. | 22784549 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | This provides one mechanism in which putative cancer stem cells could survive and may lead to tumour relapse. | 22784549 |
| Hypoxia, BCR gene | Stem Cell Exhaustion | Co-culture of pre-B ALL or REH cells with BM-derived mesenchymal stem cells (MSC) under hypoxia resulted in further induction of HIF-1a protein and acquisition of the glycolytic phenotype, in part via stroma-induced AKT/mTOR signaling. | 22785211 |
| Vascular System Injuries | Stem Cell Exhaustion | Circulating endothelial cells (CECs) were measured as a marker of vascular injury, with vascular repair assessed by counting colony-forming units (CFUs), also known as endothelial progenitor cells. | 22785446 |
| Acute lymphocytic leukemia, BCR gene | Stem Cell Exhaustion | Treatment of recurrent acute lymphoblastic leukaemia (ALL) often involves allogeneic stem-cell transplantation (alloSCT) and disease recurrence in the central nervous system may require craniospinal irradiation. | 22787181 |
| Glioblastoma Multiforme Pathway, Adult Glioblastoma, Astrocytoma, Glioblastoma | Stem Cell Exhaustion | Using pyrosequencing, we detected RANK/TNFRSF11A promoter methylation in 8 (57.1%) of 14 diffuse astrocytomas, 17 (77.3%) of 22 anaplastic astrocytomas, 101 (84.2%) of 120 glioblastomas, 6 (100%) of 6 glioma cell lines, and 7 (100%) of 7 glioma stem cell-enriched glioblastoma primary cultures but not in four normal white matter tissue samples. | 22787434 |
| Pterygium | Stem Cell Exhaustion | The use of fibrin glue, which has been reported extensively in pterygium and other conjunctival surgeries, has not been fully described in limbal stem cell transplantation. | 22788584 |
| Acute GVH disease | Stem Cell Exhaustion | A 26-year-old man received FK506 to prevent acute graft-versus-host disease after hematopoietic stem cell transplantation. | 22790031 |
| Graft-vs-Host Disease, Secondary Graft Failure After Hematopoietic Cell Transplantation, Primary Graft Failure After Hematopoietic Cell Transplantation, Communicable Diseases | Stem Cell Exhaustion | In patients with secondary failure of platelet recovery (N=7) as well as primary failure after hematopoietic stem cell transplantation, TPO levels were very high, reflecting impaired platelet production due to GVHD, drug treatments, and infection. | 22790640 |
| Hiccough, Diarrhea, Abdomen distended | Stem Cell Exhaustion | His presentation with hiccups, abdominal and neck distension, along with diarrhoea was also unusual, and this case highlights the need for a high index of suspicion when treating post stem cell transplant patients. | 22791490 |
| Aplastic Anemia | Stem Cell Exhaustion | Aplastic anemia is a rare disease caused by destruction of pluripotent stem cells in bone marrow. | 22796618 |
| Medial collateral ligament | Stem Cell Exhaustion | Patients with MCL who underwent autologous stem-cell transplantation (ASCT) in our institution were eligible for the present study (n=73). | 22797728 |
| Femoral Neuropathy | Stem Cell Exhaustion | The patient had a total hip replacement at a specialist orthopaedic hospital and is due to undergo radiotherapy to the femoral lesion and autologous stem cell transplantation. | 22798312 |
| Adult Glioblastoma | Stem Cell Exhaustion | MGMT hypermethylation and MDR system in glioblastoma cancer stem cells. | 22798502 |
| Glioma, Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells (CSCs) in gliomas are associated with resistance to radio- and chemotherapy, based on O(6)-methylguanine-DNA methyltransferase (MGMT) hypermethylation and the Multidrug resistance (MDR) system activation. | 22798502 |
| Arrhythmogenic Right Ventricular Dysplasia | Stem Cell Exhaustion | Generation of patient-specific induced pluripotent stem cell-derived cardiomyocytes as a cellular model of arrhythmogenic right ventricular cardiomyopathy. | 22798562 |
| Multiple Myeloma | Stem Cell Exhaustion | Significance of oligoclonal bands after stem cell transplantation in multiple myeloma cases. | 22799352 |
| nervous system disorder | Stem Cell Exhaustion | Analysis of post-mortem frontal cortex tissue from 7 GBA mutation carriers with LBD, 5 GBA mutation carriers with no signs of neurological disease and human neural stem cells exposed to a GCase inhibitor was used to determine how GBA mutation contributes to LBD. | 22803570 |
| Pneumonia | Stem Cell Exhaustion | Organizing pneumonia in recipients of hematopoietic stem cell transplantation: CT features in 16 patients. | 22805673 |
| Pneumonia | Stem Cell Exhaustion | To evaluate computed tomographic (CT) scans of patients with organizing pneumonia (OP) complicating hematopoietic stem cell transplantation (HSCT). | 22805673 |
| Kidney Diseases | Stem Cell Exhaustion | De novo postallogeneic hematopoietic stem cell transplant membranous nephropathy. | 22809119 |
| Kidney Diseases, Chronic graft-versus-host disease | Stem Cell Exhaustion | We report membranous nephropathy in a 61-year-old man after allogeneic hematopoietic stem cell transplant without chronic graft-versus-host disease. | 22809119 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | A diagnosis of acute myeloid leukemia was made, and the patient received hematopoietic stem cell transplants, twice, from different donors. | 22809119 |
| Chronic graft-versus-host disease, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | His clinical course was stable without acute or chronic graft-versus-host disease or relapse of acute myeloid leukemia with tacrolimus after the second hematopoietic stem cell transplant. | 22809119 |
| Kidney Diseases, Chronic graft-versus-host disease | Stem Cell Exhaustion | These results suggest that this membranous nephropathy may have been de novo membranous nephropathy after hematopoietic stem cell transplant because it developed after hematopoietic stem cell transplants without chronic graft-versus-host disease. | 22809119 |
| Ischemia | Stem Cell Exhaustion | Ischemia may induce brain self-repair in neonatal rats, resulting in activation and proliferation of NG2 glial progenitor cells in the SVZ migration and differentiation into OL precursor cells in periventricular white matter. | 22809613 |
| Mycoses | Stem Cell Exhaustion | Comparison of posaconazole versus weekly amphotericin B lipid complex for the prevention of invasive fungal infections in hematopoietic stem-cell transplantation. | 22814329 |
| Mycoses | Stem Cell Exhaustion | Antifungal prophylaxis is shown to decrease the risk of invasive fungal infection (IFI) after hematopoietic stem-cell transplantation (HSCT). | 22814329 |
| Chronic Kidney Disease, CTCAE | Stem Cell Exhaustion | Value and level of circulating endothelial progenitor cells, angiogenesis factors and mononuclear cell apoptosis in patients with chronic kidney disease. | 22814956 |
| Kidney Failure, Chronic, Chronic Kidney Diseases, Chronic Kidney Disease, CTCAE | Stem Cell Exhaustion | Chronic renal failure on dialysis can reduce the number of circulating endothelial progenitor cells (EPCs), but this biomarker has not been fully investigated in patients with chronic kidney disease (CKD). | 22814956 |
| Hepatic Encephalopathy, Multiple Myeloma | Stem Cell Exhaustion | Posterior reversible encephalopathy syndrome postautologous peripheral stem cell transplantation for multiple myeloma. | 22814980 |
| Multiple Myeloma | Stem Cell Exhaustion | This is a case of a 56-year-old lady with recent autologous peripheral stem cell transplantation for multiple myeloma. | 22814980 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Patients with multiple myeloma (MM) undergoing high dose therapy and autologous stem cell transplantation (SCT) remain at risk for disease progression. | 22816680 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | To better understand clonal evolution in AML, we sequenced the genomes of M3-AML samples with a known initiating event (PML-RARA) versus the genomes of normal karyotype M1-AML samples and the exomes of hematopoietic stem/progenitor cells (HSPCs) from healthy people. | 22817890 |
| Lupus Erythematosus | Stem Cell Exhaustion | Upregulation of p16INK4A promotes cellular senescence of bone marrow-derived mesenchymal stem cells from systemic lupus erythematosus patients. | 22820504 |
| Lupus Erythematosus, Systemic, Encephalitis, St. Louis | Stem Cell Exhaustion | Previous studies have indicated that bone marrow-derived mesenchymal stem cells (MSCs) from patients with systemic lupus erythematosus (SLE) exhibited impaired proliferation, differentiation, and immune modulation capacities. | 22820504 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | Allogeneic stem cell transplantation for older advanced MDS patients: improved survival with young unrelated donor in comparison with HLA-identical siblings. | 22821073 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | We investigated whether a young human leukocyte antigen (HLA)-matched unrelated donor (MUD) should be preferred as donor to an HLA-identical sibling (MRD) for older patients with myelodysplastic syndrome (MDS) (>= 50 years) who underwent allogeneic stem cell transplantation (AHSCT). | 22821073 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | Functional study of risk loci of stem cell-associated gene lin-28B and associations with disease survival outcomes in epithelial ovarian cancer. | 22822098 |
| Cancer Pain, Malignant neoplasm of ovary | Stem Cell Exhaustion | Several single-nucleotide polymorphisms (SNPs) of the stem cell-associated gene lin-28B have been identified in association with ovarian cancer and ovarian cancer-related risk factors. | 22822098 |
| Specialty Type - cancer | Stem Cell Exhaustion | These results suggest that rs314276 alters RNA secondary structure and thereby influences gene expression, and that lin-28B is a cancer stem cell-associated marker, which may be a pharmaceutical target in the management of EOC. | 22822098 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | We report the case of a 61-year-old man who had hematopoietic stem cell transplant for myelodysplastic syndrome. | 22823898 |
| Adult Glioblastoma | Stem Cell Exhaustion | In this study, we characterized p53 isoform expression patterns in glioblastoma, gliosis, non-tumor brain and neural progenitor cells by SDS-PAGE, immunoblot, mass spectrometry and reverse transcription-PCR. | 22824800 |
| Adult Glioblastoma, Neoplasms | Stem Cell Exhaustion | We found that the most consistently expressed isoform in glioblastoma, D40p53, was uniquely expressed in regenerative processes, such as those involving neural progenitor cells and gliosis compared with tumor samples. | 22824800 |
| Pancreatic Ductal Adenocarcinoma, Pancreatic intraepithelial neoplasia, Specialty Type - cancer | Stem Cell Exhaustion | Expression of cancer stem cell markers in pancreatic intraepithelial neoplasias and pancreatic ductal adenocarcinomas. | 22824809 |
| Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | Cancer stem cells (CSCs) play pivotal roles in cancer growth, invasion, metastasis and recurrence. | 22824809 |
| Liver Cirrhosis | Stem Cell Exhaustion | Increased number and function of endothelial progenitor cells stimulate angiogenesis by resident liver sinusoidal endothelial cells (SECs) in cirrhosis through paracrine factors. | 22824816 |
| Liver Cirrhosis | Stem Cell Exhaustion | The present study focused on numbers and angiogenic functions of circulating endothelial progenitor cells (EPCs) in patients with cirrhosis. | 22824816 |
| Aplastic Anemia | Stem Cell Exhaustion | A novel autologous stem cell procedure for the treatment of aplastic anaemia using reprogrammed mature adult cells: a pilot study. | 22825605 |
| Aplastic Anemia | Stem Cell Exhaustion | This autologous approach of stem cell creation may broaden the curative potentials of stem cell therapy to a wider population of patients with aplastic anaemia, including many patients suffering from other haematological and non-haematological disorders. | 22825605 |
| Aplastic Anemia | Stem Cell Exhaustion | Herein, the safety and efficacy of infusing autologous retrodifferentiated haematopoietic stem cells (RHSC) into four patients with aplastic anaemia without the use of any pre- or post-conditioning regimen including immunosuppression is described. | 22825605 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The KIT gene is a receptor tyrosine kinase class III expressed by early hematopoietic progenitor cells and plays a significant role in hematopoietic stem cell proliferation, differentiation and survival which is considered to be a remarkable feature in the course of growth of acute myeloid leukaemia (AML). | 22825855 |
| Sarcoma of vulva, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We report a case of vulvar myeloid sarcoma presenting as isolated relapse of acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplant (HSCT). | 22828376 |
| Therapy-Related Toxicity | Stem Cell Exhaustion | In allogeneic hematopoietic stem cell transplantation (allo-HSCT) therapy-related toxicity and alloreactivity increase inflammatory cytokines that might favor an MDSC accumulation. | 22828446 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Complex karyotype (CK) on metaphase cytogenetics discriminates poor outcome in chronic lymphocytic leukaemia (CLL) patients undergoing salvage treatment; we hypothesized that it might provide prognostic information for patients undergoing allogeneic stem cell transplant. | 22831395 |
| Medial collateral ligament | Stem Cell Exhaustion | Survival improvement has recently been achieved for patient with MCL by the successful introduction of monoclonal antibodies and dose-intensified approaches for treatment, including autologous stem cell transplantation strategies. | 22832802 |
| Heart Diseases | Stem Cell Exhaustion | The effects of age, disease state, and granulocyte colony-stimulating factor on progenitor cell count and function in patients undergoing cell therapy for cardiac disease. | 22834565 |
| Heart failure, Acute myocardial infarction, Dilated Cardiomyopathy Pathway, Myocardial Ischemia, Doctor of Chiropractic | Stem Cell Exhaustion | In this exploratory analysis, we assessed the impact of age, different disease states, and granulocyte colony-stimulating factor (G-CSF) therapy on progenitor cell concentration and function in patients recruited to our clinical trials of BMSC therapy for ischaemic heart failure (IHD), dilated cardiomyopathy (DCM), and acute myocardial infarction (AMI). | 22834565 |
| Chronic graft-versus-host disease | Stem Cell Exhaustion | Allogeneic peripheral blood stem cell transplantation significantly increases risk of chronic graft-versus-host disease of lung compared with bone marrow transplantation. | 22835425 |
| Bare Lymphocyte Syndrome, Peripheral Blood Stem Cells, Lymphohistiocytosis, Hemophagocytic | Stem Cell Exhaustion | Passenger lymphocyte syndrome with hemophagocytic syndrome after peripheral blood stem-cell transplantation from an HLA-matched full biological sibling: case report. | 22836124 |
| Bare Lymphocyte Syndrome, Hemolysis (biological function), Papillon-Lefevre Disease | Stem Cell Exhaustion | Massive hemolysis due to passenger lymphocyte syndrome (PLS) is rare after peripheral blood stem-cell (PBSC) transplantation with a minor ABO mismatch. | 22836124 |
| Acute lymphocytic leukemia, Lymphoma, Myeloid Leukemia, Chronic, Myeloid, Leukemic Blast Count, Leukemia, Myelocytic, Acute, BCR gene | Stem Cell Exhaustion | Its expression was observed in hematopoietic CD34+ stem cells, erythropoietic, myeloid and lymphoblastic lineages cell lines and in human leukemic blast cells in lymphomas, acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and chronic myeloid leukemia (CML). | 22836631 |
| Liver Cirrhosis | Stem Cell Exhaustion | Stem cell niche activation (as indicated as a ductular reaction) was highest in cases of cirrhosis (p = 0.001) and correlated with CK19 expression (r = 0.42, p = 0.012), the grade(r = 0.56, p = 0.024) and stage (0.66, p = 0.006). | 22839096 |
| Fibrosis Assessment, Hollings Cancer Center, Carcinogenesis | Stem Cell Exhaustion | Fibrosis promotes carcinogenesis by fibroblast-secreted gremlin that blocks BMP function and promotes stem cell activation and proliferation as well as possibly HCC development. | 22839096 |
| LMNA wt Allele | Stem Cell Exhaustion | Recent studies based on induced pluripotent stem cells derived from HGPS patient cells have revealed a lack of expression in neural derivatives of lamin A, a major isoform of LMNA that is initially produced as a precursor called prelamin A. | 22840390 |
| Acute lymphocytic leukemia, BCR gene | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (SCT) is routinely offered to suitable candidates with high-risk or advanced acute lymphoblastic leukemia (ALL). | 22842330 |
| Amyloidosis | Stem Cell Exhaustion | Amyloid deposits in the bone marrow of patients with immunoglobulin light chain amyloidosis do not impact stem cell mobilization or engraftment. | 22842332 |
| Multiple Myeloma | Stem Cell Exhaustion | Comparative diagnostic performance of 18F-FDG PET/CT versus whole-body MRI for determination of remission status in multiple myeloma after stem cell transplantation. | 22843058 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | To compare the diagnostic performance of whole-body magnetic resonance imaging (WBMRI) versus (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) for determination of remission status in patients with multiple myeloma (MM) after stem cell transplantation (SCT). | 22843058 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | Detection of mesenchymal and cancer stem cells, which are tumor-initiating cells, is more relevant than simple counting of CTCs to assess their presence in the blood of patients with breast cancer. | 22843916 |
| Graft-vs-Host Disease, Leukemia, Myelocytic, Acute, Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | Regression of a renal cell carcinoma following allogeneic peripheral blood stem cell transplant for acute myeloid leukaemia: evidence of a graft-versus-tumour effect without significant graft-versus-host disease. | 22845006 |
| Glioma, Aortic Aneurysm, Specialty Type - cancer | Stem Cell Exhaustion | This study evaluated the safety and immune responses to an autologous dendritic cell vaccine pulsed with class I peptides from tumor-associated antigens (TAA) expressed on gliomas and overexpressed in their cancer stem cell population (ICT-107). | 22847020 |
| Adult Glioblastoma, Neoplasms | Stem Cell Exhaustion | The goal of targeting tumor antigens highly expressed on glioblastoma cancer stem cells is supported by the observation of decreased or absent CD133 expression in the recurrent areas of gadolinium-enhanced tumors. | 22847020 |
| Thrombocytosis, Hematological Disease, Primary Myelofibrosis, Myeloid Leukemia, Chronic, Polycythemia Vera, Chronic myeloproliferative disorder, PRSS27 gene | Stem Cell Exhaustion | Chronic myeloproliferative neoplasms (MPN) are clonal disorders of hematopoietic stem cells, which fall into distinct categories based on a number of characteristics including the presence of the BCR-ABL1 gene fusion (chronic myelogenous leukemia) or the JAK2(V617F) mutation (polycythemia vera, primary myelofibrosis, and essential thrombocythemia). | 22847163 |
| Disease, Neurodegenerative Disorders | Stem Cell Exhaustion | Induced pluripotent stem cell (iPSC) technology can be used to model human disorders, create cell-based models of human diseases, including neurodegenerative diseases, and in establishing therapeutic strategies. | 22848530 |
| Neurodegenerative Disorders | Stem Cell Exhaustion | Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research. | 22848530 |
| Teratoma | Stem Cell Exhaustion | It is postulated that the teratoid elements might derive from multipotential less-differentiated stem cells. | 22849740 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Therapeutic drug monitoring of posaconazole in allogeneic hematopoietic stem cell transplantation patients who develop gastrointestinal graft-versus-host disease. | 22850515 |
| Graft-vs-Host Disease, Immunocompromised Host, Aspergillosis | Stem Cell Exhaustion | Posaconazole (PCZ) is the latest triazole antifungal agent that has been approved for prophylaxis of invasive aspergillosis in high-risk immunocompromised patients, such as allogeneic hematopoietic stem cell transplantation patients, who develop graft-versus-host disease (GVHD). | 22850515 |
| Graft-vs-Host Disease, Diarrhea, Aspergillosis | Stem Cell Exhaustion | To determine the variability factors in plasma drug concentrations, the PCZ C(min) and clinical parameters (localization of GVHD, presence of diarrhea, and diagnosis of invasive aspergillosis) were collected retrospectively in 29 consecutive allogeneic hematopoietic stem cell transplantation patients who developed GVHD and were receiving prophylactic PCZ (200 mg, 3 times/day, for >=7 days). | 22850515 |
| Immunocompromised Host, Systemic EBV positive T-cell lymphoproliferative disease of childhood, Lymphohistiocytosis, Hemophagocytic | Stem Cell Exhaustion | Hosts that are immunocompromised after hematopoietic stem cell transplantations sometimes suffer from systemic EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH) and EBV-positive lymphoma. | 22850617 |
| Pulmonary Emphysema | Stem Cell Exhaustion | Impaired colony-forming capacity of circulating endothelial progenitor cells in patients with emphysema. | 22850689 |
| Heart failure | Stem Cell Exhaustion | The impressive recovery in ventricular hemodynamics and anatomy mediated by clonal hCSCs carrying the "mother" DNA underscores the clinical relevance of this stem cell class for the management of heart failure in humans. | 22851539 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | Up-front autologous stem-cell transplantation in peripheral T-cell lymphoma: NLG-T-01. | 22851556 |
| Peripheral T-Cell Lymphoma, Lymphoma | Stem Cell Exhaustion | To evaluate the efficacy of a dose-dense approach consolidated by up-front high-dose chemotherapy (HDT) and autologous stem-cell transplantation (ASCT) in PTCL, the Nordic Lymphoma Group (NLG) conducted a large prospective phase II study in untreated systemic PTCL. | 22851556 |
| Ki-1+ Anaplastic Large Cell Lymphoma | Stem Cell Exhaustion | Efficacy of peripheral blood stem cell transplantation versus conventional chemotherapy on anaplastic large-cell lymphoma:a retrospective study of 64 patients from a single center. | 22854061 |
| Ki-1+ Anaplastic Large Cell Lymphoma | Stem Cell Exhaustion | Many groups believed aggressive treatment strategies such as autologous stem cell transplantation brought survival benefit for ALCL patients. | 22854061 |
| Ki-1+ Anaplastic Large Cell Lymphoma | Stem Cell Exhaustion | Here, we report a study comparing the efficacy of peripheral blood stem cell transplantation (PBSCT) and conventional chemotherapy on ALCL. | 22854061 |
| Hodgkin Disease, LIPC gene | Stem Cell Exhaustion | Brentuximab vedotin induces durable objective responses in patients with relapsed or refractory Hodgkin lymphoma (HL) after autologous stem cell transplantation (ASCT). | 22855426 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Our goal was to investigate the outcomes associated with distinct high-risk chromosomal abnormalities in acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (HSCT). | 22855604 |
| Colorectal Carcinoma, Specialty Type - cancer, Cytogenetic Complete Response | Stem Cell Exhaustion | CD133 is considered a useful marker to identify the so-called cancer stem cells in colorectal cancers (CRCs) and its expression has been shown to have prognostic significance in CRC patients. | 22856425 |
| Delirium | Stem Cell Exhaustion | Risk factors for delirium in patients undergoing hematopoietic stem cell transplantation. | 22860240 |
| Delirium | Stem Cell Exhaustion | Delirium is common after hematopoietic stem cell transplantation (HSCT) and is associated with increased morbidity and mortality. | 22860240 |
| Venous Thrombosis, Paroxysmal nocturnal hemoglobinuria, Acquired disorder, Anemia, Hemolytic | Stem Cell Exhaustion | PNH is an acquired disorder of stem cells, and the common manifestations are complement mediated hemolytic anemia and deep venous thrombosis. | 22860310 |
| Lung Diseases, Fungal, Hematologic Neoplasms | Stem Cell Exhaustion | Risk factors for invasive pulmonary fungal infection in patients with hematological malignancies not receiving hematopoietic stem cell transplant. | 22862167 |
| Lung Diseases, Fungal, Hematologic Neoplasms | Stem Cell Exhaustion | We investigated the incidence, pathogens and risk factors of invasive pulmonary fungal infection (IPFI) in patients with hematological malignancies who did not receive hematopoietic stem cell transplantation (HSCT). | 22862167 |
| Enterocolitis, Neutropenic | Stem Cell Exhaustion | Neutropenic enterocolitis after high-dose chemotherapy and autologous stem cell transplantation: incidence, risk factors, and outcome. | 22862907 |
| Enterocolitis, Neutropenic | Stem Cell Exhaustion | Neutropenic enterocolitis (NE) is a life-threatening complication occurring after intensive chemotherapy; however, no data are available on NE development after hematopoietic stem cell transplantation (SCT). | 22862907 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Long-term survival in patients with metastatic breast cancer receiving intensified chemotherapy and stem cell rescue: data from the Italian registry. | 22863724 |
| diabetic | Stem Cell Exhaustion | Prompt increases in retinol-binding protein 4 and endothelial progenitor cells during acute exercise load in diabetic subjects. | 22863748 |
| diabetic | Stem Cell Exhaustion | The present study was undertaken to determine whether acute exercise load alters serum retinol-binding protein 4 (RBP4) and numbers of endothelial progenitor cells (EPC) in diabetic subjects. | 22863748 |
| Have Been Vomiting, Nausea | Stem Cell Exhaustion | Prevention of nausea and vomiting associated with stem cell transplant: results of a prospective, randomized trial of aprepitant used with highly emetogenic preparative regimens. | 22863840 |
| Have Been Vomiting, Nausea | Stem Cell Exhaustion | Uncontrolled delayed nausea and vomiting remains a problem after high-dose preparative regimens used for autologous and allogeneic hematopoietic stem cell transplants. | 22863840 |
| Carcinoma of ampulla of Vater | Stem Cell Exhaustion | We measured the serum levels of the hematopoietic cytokines stem cell factor (SCF), interleukin 3 (IL-3), macrophage-colony stimulating factor (M-CSF) and granulocyte-macrophage-colony stimulating factor (GM-CSF) in 40 pancreatic and ampullary cancer patients and 40 healthy volunteers, using ELISA. | 22865301 |
| BCR gene | Stem Cell Exhaustion | HLAA, -B, and -DRB1 allele distributions in 156 ALL patients (aged 3-54 years) were analyzed and compared with unrelated healthy hematopoietic stem cell donors from the same ethnic and geographic background. | 22868506 |
| Ischemia | Stem Cell Exhaustion | Possible predictors of poor angiogenesis after hematopoietic stem cell autograft for lower limb ischemia. | 22869247 |
| Ischemia | Stem Cell Exhaustion | Identify candidate predictors of poor angiogenesis, as indicated by need for amputation, after autologous hematopoietic stem cell transplantation for chronic lower limb ischemia. | 22869247 |
| Ischemia | Stem Cell Exhaustion | The study universe was composed of 47 patients (19 women, 28 men) with critical lower limb ischemia in Fontaine stages IIb, III and IV, who received autologous stem cell transplantation at the Dr Gustavo Aldereguia Lima University General Hospital in Cienfuegos, Cuba, from January 2007 through December 2010. | 22869247 |
| Peripheral Vascular Diseases | Stem Cell Exhaustion | The therapeutic potential of adult stem cells in coronary and peripheral arterial diseases has been proposed in recent years. | 22869247 |
| Bronchiolitis Obliterans | Stem Cell Exhaustion | Lung transplantation for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. | 22869493 |
| Bronchiolitis Obliterans, bottle - unit dose | Stem Cell Exhaustion | Bronchiolitis obliterans (BO) is a late onset complication of allogeneic hematopoietic stem cell transplantation (HSCT), and treatment outcome is dismal if it does not respond to immunosuppressive therapy. | 22869493 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | HLA-mismatched unrelated donor (MMUD) hematopoietic stem-cell transplantation (HSCT) is associated with increased graft-versus-host disease (GVHD) and impaired survival. | 22869883 |
| Peripheral Blood Stem Cells, Hematologic Neoplasms | Stem Cell Exhaustion | We conducted a prospective phase I/II trial of a GVHD prophylaxis regimen of short-course bortezomib, administered once per day on days +1, +4, and +7 after peripheral blood stem-cell infusion plus standard tacrolimus and methotrexate in patients with hematologic malignancies undergoing MMUD RIC HSCT. | 22869883 |
| Adenocarcinoma of large intestine | Stem Cell Exhaustion | This study shows that CD133 is able to mark colorectal adenocarcinoma but it is still unclear at this juncture whether CD133 is indeed a marker for colorectal adenocarcinoma "stem cells". | 22870594 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Further investigations on how high expression of CXCR4 and EMT occur in this identified cancer stem cell subset are warranted to provide insights into our understanding of tumor biology. | 22871210 |
| Specialty Type - cancer | Stem Cell Exhaustion | Growing evidence suggests that a subset of cells exists among cancer stem cells. | 22871210 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal hematopoietic stem cell diseases. | 22873198 |
| Toxic effect | Stem Cell Exhaustion | Ketamine induces toxicity in human neurons differentiated from embryonic stem cells via mitochondrial apoptosis pathway. | 22873495 |
| Multiple Myeloma | Stem Cell Exhaustion | Risk factors for unsuccessful peripheral blood stem cell harvesting using granulocyte-colony stimulating factor mobilization in patients with multiple myeloma. | 22874435 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | The aim of this study was to determine factors that influence unsuccessful peripheral blood stem cell (PBSC) harvesting in patients with multiple myeloma (MM). | 22874435 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Daily surveillance blood cultures were taken from patients treated with corticosteroids as part of their intensive chemotherapy or during graft-versus-host disease following hematopoietic stem cell transplantation during a 3-year period (2006-2009). | 22875415 |
| HD Term Type | Stem Cell Exhaustion | In this study, we aimed to assess the therapeutic potential of a human striatal neural stem cell line (STROC05) implanted in the R6/2 transgenic mouse model of HD. | 22876937 |
| Huntingtons Disease Pathway | Stem Cell Exhaustion | Implantation of undifferentiated and pre-differentiated human neural stem cells in the R6/2 transgenic mouse model of Huntington's disease. | 22876937 |
| Hematological Disease, Hemorrhage, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Patients aged 16-80 years, who were undergoing intensive chemotherapy for acute myeloid leukaemia or autologous haemopoietic stem-cell transplantation for haematological cancers, were randomly assigned via a computer-generated randomisation sequence to receive either platelet transfusion when bleeding occurred (therapeutic strategy) or when morning platelet counts were 10x10(9) per L or lower (prophylactic strategy). | 22877506 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The therapeutic strategy could become a new standard of care after autologous stem-cell transplantation; however, prophylactic platelet transfusion should remain the standard for patients with acute myeloid leukaemia. | 22877506 |
| Neoplasms, Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | Aldehyde dehydrogenase 1 (ALDH1) has been suggested as a surrogate biomarker for cancer stem cells in breast cancer and other tumors. | 22877687 |
| Mucocutaneous candidiasis | Stem Cell Exhaustion | To investigate the morphology of the human eyelid margin and the presence of different cytokeratins, mucins and stem cell markers within the skin epithelium, mucocutaneous junction (MCJ) and palpebral conjunctiva. | 22877886 |
| Meibomian gland dysfunction, Dry Eye Syndromes | Stem Cell Exhaustion | Additionally, the knowledge of distribution of biomarkers like cytokeratins, mucins and stem cells can be useful in the investigation of MCJ disturbances which occur in several disorders of the meibomian glands and the lid epithelium in the course of dry eye syndrome and especially meibomian gland dysfunction. | 22877886 |
| Specialty Type - cancer | Stem Cell Exhaustion | Aldehyde dehydrogenase 1A1 (ALDH1A1) has been described as a cancer stem cell marker and as a regulator of cellular chemoresistance. | 22878609 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | Stem cell transplantation for paediatric patients with non-anaplastic peripheral T-cell lymphoma in Japan. | 22881201 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | Reports of non-anaplastic peripheral T-cell lymphoma (PTCL) in paediatric patients, especially results of stem cell transplantation (SCT), are relatively rare. | 22881201 |
| SERPINB3 wt Allele | Stem Cell Exhaustion | This study aimed to assess the value of the expression of poly(ADP-ribose) polymerase 1 (PARP-1), chromatin assembly factor-1 (CAF-1)/p60 and the stem cell markers CD133, CD166, CD44, CD44v6 and nestin as markers of outcome and progression-free survival in OSCC patients. | 22882088 |
| myocardial injury | Stem Cell Exhaustion | Myocardial injury recruits endothelial progenitor cells (EPCs) to the site of damage and stimulates their differentiation, contributing to myocardial tissue repair. | 22882964 |
| B-Cell Lymphomas | Stem Cell Exhaustion | Patients with diffuse large B cell lymphoma in partial response or stable disease after first-line R-CHOP: the prognostic value of the absolute lymphocyte count and impact of autologous stem cell transplantation. | 22885989 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Despite improvements in the prevention and treatment of graft-versus-host disease (GvHD) this allogeneic immune response is still one of major complications following allogeneic stem cell transplantation (SCT). | 22889700 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Bone marrow mesenchymal stem cells in myelodysplastic syndromes: cytogenetic characterization. | 22890308 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | This study compared genetic aberrations in hematopoietic cells (HCs) and mesenchymal stem cells of myelodysplastic syndrome (MDS-MSCs) patients. | 22890308 |
| Diarrhea, Gastrointestinal mucositis | Stem Cell Exhaustion | Clinical factors such as mucositis, diarrhea, and the early posttransplant period in hematopoietic stem cell transplant recipients were also associated with reduced posaconazole exposure (P < 0.01). | 22890761 |
| Traumatic | Stem Cell Exhaustion | Autologous bone marrow mesenchymal stem cell therapy in the subacute stage of traumatic brain injury by lumbar puncture. | 22891928 |
| Traumatic | Stem Cell Exhaustion | To explore the clinical therapeutic effects and safety of autologous bone marrow mesenchymal stem cell therapy for traumatic brain injury by lumbar puncture. | 22891928 |
| Disturbance in physical behavior, Traumatic, Lesion of brain | Stem Cell Exhaustion | A total of 97 patients (24 with persistent vegetative state and 73 with disturbance motor activity) who developed a complex cerebral lesion after traumatic brain injury received autologous bone marrow mesenchymal stem cell therapy voluntarily. | 22891928 |
| Motor Disorders, Traumatic | Stem Cell Exhaustion | This study suggests that the bone marrow stem cell therapy is safe and effective on patients with traumatic brain injury complications, such as persistent vegetative state and motor disorder, through lumbar puncture. | 22891928 |
| Multiple Myeloma | Stem Cell Exhaustion | A phase I dose-escalation trial of high-dose melphalan with palifermin for cytoprotection followed by autologous stem cell transplantation for patients with multiple myeloma with normal renal function. | 22892551 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Melphalan 200 mg/m(2) is the standard conditioning regimen for patients with multiple myeloma (MM) with normal renal function (NRF) undergoing autologous stem cell transplant (ASCT). | 22892551 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Donor compatibility and performance status affect outcome of allogeneic haematopoietic stem cell transplant in patients with relapsed or refractory acute myeloid leukaemia. | 22893485 |
| Specialty Type - cancer | Stem Cell Exhaustion | Chemoresistant cells, which potentially also display cancer stem cell (CSC) characteristics, can be isolated using the side population (SP) technique. | 22894607 |
| diabetic | Stem Cell Exhaustion | Far infra-red therapy promotes ischemia-induced angiogenesis in diabetic mice and restores high glucose-suppressed endothelial progenitor cell functions. | 22894755 |
| Stable chronic Graft vs Host Disease, Peripheral | Stem Cell Exhaustion | As BAFF increases murine B-cell metabolism and survival and maintains autoreactive B-cell clones, we performed ex vivo analyses of peripheral B cells from 51 patients who either had or did not have active cGVHD and were greater than 1 year from the time of allogeneic hematopoietic stem cell transplantation. | 22896003 |
| Multiple Myeloma | Stem Cell Exhaustion | Plerixafor appears to have effects on blood stem cell graft composition in myeloma patients. | 22897584 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Cyclophosphamide (CY) combined with granulocyte-colony-stimulating factor (G-CSF) is commonly used to mobilize stem cells in multiple myeloma (MM). | 22897584 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | We retrospectively analyzed data of 40 consecutive adult patients with relapsed and refractory peripheral T-cell lymphoma referred to our institution for consideration of second-line chemotherapy aiming for autologous stem cell transplant between January 1999 and December 2006. | 22897731 |
| Peripheral T-Cell Lymphoma, B-Cell Lymphomas | Stem Cell Exhaustion | Post-autologous stem cell transplant, 1-year progression-free survival was 20% (95% CI: 9-48) for patients with peripheral T-cell lymphoma and 47% (95% CI: 36-61) for patients with diffuse large B-cell lymphoma. | 22897731 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | Likely due to imbalances in risk factors at relapse, progression-free survival post-autologous stem cell transplant was inferior in the peripheral T-cell lymphoma group. | 22897731 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | Strategies aiming to maintain response duration post-autologous stem cell transplant could improve the outcome of patients with peripheral T-cell lymphoma. | 22897731 |
| Multiple Myeloma | Stem Cell Exhaustion | Intravenous busulfan and melphalan as a conditioning regimen for autologous stem cell transplantation in patients with newly diagnosed multiple myeloma: a matched comparison to a melphalan-only approach. | 22897964 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Melphalan 200 mg/m(2) (MEL200) is the standard conditioning regimen administered to newly diagnosed patients with multiple myeloma (MM) undergoing autologous stem cell transplantation (ASCT). | 22897964 |
| BCR gene | Stem Cell Exhaustion | This study assesses the safety and efficacy of oral imatinib in association with a Berlin-Frankfurt-Munster intensive chemotherapy regimen and allogeneic stem-cell transplantation for paediatric patients with Philadelphia-chromosome-positive ALL. | 22898679 |
| Hereditary hemorrhagic telangiectasia, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Homoharringtonine (HHT), a valid drug for treating chronic myelogenous leukemia, has shown some effect on leukemic stem cells. | 22898909 |
| Neoplasms, Nerve Degeneration | Stem Cell Exhaustion | The Esophageal cancer-related gene-4 (Ecrg4) is a candidate tumor suppressor gene whose secreted protein product has been implicated in the development and progression of epithelial cancers, neuroprogenitor cell activation after central nervous system injury, cell senescence in neurodegeneration, and the survival of hematopoietic stem cells. | 22899245 |
| melanoma | Stem Cell Exhaustion | Recent studies have demonstrated strong expression of neural stem/progenitor cell markers nestin and SOX2 in melanoma. | 22899289 |
| Specialty Type - cancer | Stem Cell Exhaustion | These findings suggest that cancer stem-like cells/tumor-initiating cells are linked to more aggressive behavior of upper urinary tract urothelial cell carcinoma, supporting the current cancer stem cell hypothesis. | 22899292 |
| Prostate carcinoma | Stem Cell Exhaustion | p63 cytoplasmic aberrance is associated with high prostate cancer stem cell expression. | 22901151 |
| Prostate carcinoma | Stem Cell Exhaustion | Maintenance of normal stem cell or reserve cell populations in several epithelia including prostate has been shown to be regulated by p63 and alteration of p63 expression is considered to have an oncogenic role in prostate cancer. | 22901151 |
| Prostate carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | We hypothesize that the expression of cytoplasmic aberrance of p63 is associated with high ALDH1A1 expression as a cancer stem cell marker, thus leading to progression of prostate cancer. | 22901151 |
| Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | It has been suggested that stem cells in the prostate gland have a role in initiation, progression, and metastasis of cancer, although controversy continues to exist. | 22901151 |
| varicella zoster, herpesvirus 3, human, Communicable Diseases | Stem Cell Exhaustion | Severe disseminated varicella zoster virus (VZV) infection rarely occurs in patients who are not recipients of hematopoietic stem cell transplantation. | 22903849 |
| Graft-vs-Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Chronic graft-versus-host disease (GVHD) is a common long-term complication of allogeneic hematopoietic stem-cell transplantation (HSCT), and is responsible for morbidity, mortality and a decrease in quality of life of patients after SCT. | 22903864 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | To evaluate the long-term effects of peripheral blood stem cell therapy in myocardial infarction (MI) patients. | 22904565 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Five-year results of intracoronary infusion of the mobilized peripheral blood stem cells by granulocyte colony-stimulating factor in patients with myocardial infarction. | 22904565 |
| Acute Promyelocytic Leukemia, Neoplasms, Malignant Neoplasms | Stem Cell Exhaustion | Promyelocytic leukemia protein (PML) was originally identified as a tumor suppressor but has been recently shown to have the ability to control stem cell function in multiple tissues including malignancies. | 22906876 |
| Central neuroblastoma | Stem Cell Exhaustion | The adult stem cell maintenance factor and Polycomb group protein, Bmi1 (B-cell-specific Moloney murine leukemia virus integration site), had a critical role at neuroblastoma initiation in the model, by repressing p53 responses in precursor cells. | 22907436 |
| Restenosis | Stem Cell Exhaustion | These patients correspond to a class of fragile subjects at high risk of cardiovascular events, and new predictors of restenosis should be contemplated, such as of eNOS polymorphism, (rs753482-A>C SNP) and circulating endothelial progenitor cells. | 22907764 |
| Primary Myelofibrosis | Stem Cell Exhaustion | Thirty myelofibrosis patients (21 males, nine females) with relapse (n = 27) or graft-rejection (n = 3) after dose-reduced allografting underwent a salvage strategy including donor lymphocyte infusions (DLIs) and/or second allogeneic haematopoietic stem cell transplantation (HSCT). | 22909192 |
| Aplastic anemia, idiopathic, Anhidrosis | Stem Cell Exhaustion | A 38-year-old man with idiopathic autoimmune aplastic anemia developed permanent diffuse skin and hair whitening and generalized anhidrosis after a successful allogeneic hematopoietic stem cell transplant. | 22911189 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Acute GVHD is a strong predictor of full donor CD3+ T cell chimerism after reduced intensity conditioning allogeneic stem cell transplantation. | 22911907 |
| platelet dysfunction, Congenital anemia, Decreased platelet count | Stem Cell Exhaustion | Severe congenital anemia (hemoglobin 72 g/L), thrombocytopenia (42xG/L) and profound platelet dysfunction led a stem cell defect to be suspected. | 22915449 |
| Amyotrophic Lateral Sclerosis | Stem Cell Exhaustion | Human neural stem cell replacement therapy for amyotrophic lateral sclerosis by spinal transplantation. | 22916141 |
| MPV17 gene | Stem Cell Exhaustion | Activated parietal epithelial cells are proposed to contribute to pathogenesis of glomerulosclerosis and may serve as stem cells that can transition to podocytes. | 22917699 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndrome. | 22919028 |
| Virus Diseases | Stem Cell Exhaustion | Timeline, epidemiology, and risk factors for bacterial, fungal, and viral infections in children and adolescents after allogeneic hematopoietic stem cell transplantation. | 22922523 |
| Graft-vs-Host Disease, Stable chronic Graft vs Host Disease, Bacterial Infections, Acute GVH disease | Stem Cell Exhaustion | Era of transplantation (0-30 days), peripheral blood stem cell product, acute graft-versus-host disease (aGVHD; 31-100 days), and chronic GVHD (cGVHD; 101-730 days) were associated with higher risk for bacterial infections at the respective time periods. | 22922523 |
| Neoplasms | Stem Cell Exhaustion | Recent research suggests that tissue stem cells and the self renewal transcription factor, octamer-binding transcription factor 4 (Oct4), could be involved in the development of certain tumors. | 22922943 |
| Specialty Type - cancer | Stem Cell Exhaustion | In this study, we investigated the effects of ROS on cancer stem cells, in colorectal cancer cells. | 22923033 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | It was previously shown that chronic myeloid leukemia (CML) patients transplanted with peripheral blood progenitor cells (PBPC) from HLA-C allele-matched donors had better clinical outcome when lacking the HLA-C-encoded KIR epitope C2. | 22923051 |
| Malignant tumor of colon | Stem Cell Exhaustion | CD44 is a ubiquitously expressed cell adhesion molecule and also a potential cell surface marker on colon cancer stem cells. | 22923071 |
| Retinoblastoma | Stem Cell Exhaustion | A 6-year-old girl underwent genetic testing after developing unilateral retinoblastoma subsequent to treatment (surgery, chemotherapy, and stem-cell rescue) for a sPNET found at 1 year of age. | 22924820 |
| allergic inflammation | Stem Cell Exhaustion | Hematopoietic progenitor cells, especially those committed to the Eo/B lineage, are known to contribute to allergic inflammation. | 22925320 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | We verified that in BCR-ABL-positive progenitor cells from a CML patient and in K562 cells pSTAT5 is cytoplasmic. | 22926520 |
| Sjogrens Syndrome | Stem Cell Exhaustion | Allogeneic mesenchymal stem cell treatment alleviates experimental and clinical Sjogren syndrome. | 22927248 |
| Autoimmune state | Stem Cell Exhaustion | Importantly, treatment with mesenchymal stem cells (MSCs) suppressed autoimmunity and restored salivary gland secretory function in both mouse models and SS patients. | 22927248 |
| Hematologic Neoplasms | Stem Cell Exhaustion | We conducted an adaptive randomized trial to evaluate the effectiveness of an intermittent dosing schedule of ribavirin versus that of a continuous dosing schedule of ribavirin in preventing RSV LRTIs in 50 hematopoietic stem cell transplant recipients or patients with hematologic malignancies. | 22927454 |
| Acute Radiation Syndrome, Hematological Disease | Stem Cell Exhaustion | Long-term hematopoietic stem cell damage in a murine model of the hematopoietic syndrome of the acute radiation syndrome. | 22929468 |
| Bone Marrow | Stem Cell Exhaustion | Residual bone marrow damage (RBMD) persists for years following exposure to radiation and is believed to be due to decreased self-renewal potential of radiation-damaged hematopoietic stem cells (HSC). | 22929468 |
| Graft-vs-Host Disease, Azoospermia | Stem Cell Exhaustion | Ongoing graft-versus-host disease is a risk factor for azoospermia after allogeneic hematopoietic stem cell transplantation: a survey of the Late Effects Working Party of the European Group for Blood and Marrow Transplantation. | 22929982 |
| Spermatogenesis, Infertility | Stem Cell Exhaustion | The aim of this study was to assess the degree of spermatogenesis defects in sperm analysis in long-term male survivors after allogeneic hematopoietic stem cell transplantation in order to identify the risk factors related to potential infertility after hematopoietic stem cell transplantation and to provide data on longitudinal sperm recovery after hematopoietic stem cell transplantation. | 22929982 |
| Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | Using these cell lines, we investigated the involvement of the epithelial-mesenchymal transition (EMT) and cancer stem cell (CSCs) in AdCC metastasis by real-time RT-PCR for EMT related genes and stem cell markers. | 22931165 |
| Malignant Neoplasms, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Of the cancers treated with allogeneic hematopoietic stem-cell transplantation (HSCT), acute myeloid leukemia (AML) is most sensitive to natural killer (NK)-cell reactivity. | 22931314 |
| GDC Disease Response Terminology, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We assessed clinical data, HLA genotyping results, and donor cell lines or genomic DNA for 1277 patients with AML who had received hematopoietic stem-cell transplants from unrelated donors matched for HLA-A, B, C, DR, and DQ or with a single mismatch. | 22931314 |
| Thalassemia | Stem Cell Exhaustion | HLA-matched family hematopoetic stem cell transplantation in children with beta thalassemia major: the experience of the Turkish Pediatric Bone Marrow Transplantation Group. | 22931438 |
| Specialty Type - cancer, Glioblastoma | Stem Cell Exhaustion | Like glioblastomas, AT/RTs contain brain cancer stem cells (CSCs) that suppress the immunity of patients and are resistant to conventional chemotherapy and radiation therapy. | 22931701 |
| Agenesis | Stem Cell Exhaustion | Chronic TRF1 deletion results in increased DNA damage and cellular senescence, but not increased apoptosis, in BM progenitor cells, leading to severe aplasia. | 22932806 |
| Fulminant Hepatitis, Infection, Immunocompromised Host | Stem Cell Exhaustion | Although in profoundly immunocompromised hosts after solid organ or stem cell transplantation, adenovirus may cause fulminant hepatitis or other life-threatening infections, this is a rare complication in patients receiving standard chemotherapy. | 22935664 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | The expression status of CD74 in breast cancer stem cells and its clinical implications was evaluated in order to lay a foundation for managing breast cancer. | 22935920 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | TdT expression in acute myeloid leukemia with minimal differentiation is associated with distinctive clinicopathological features and better overall survival following stem cell transplantation. | 22936064 |
| Breast Carcinoma | Stem Cell Exhaustion | High expression of stem cell marker ALDH1 is associated with reduced BRCA1 in invasive breast carcinomas. | 22938492 |
| Breast Carcinoma, Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Cancer stem cells (CSC) have been described in a variety of malignancies, including breast carcinomas. | 22938492 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Among several markers, aldehyde dehydrogenase 1 (ALDH1) has been identified as reliable for breast cancer stem cells. | 22938492 |
| Specialty Type - cancer | Stem Cell Exhaustion | Therefore, ALDH1 positive (cancer stem) cells with reduced BRCA1 phenotype may indicate a subset of patients for whom specific targeting of the CSC marker ALDH1 and more aggressive adjuvant treatment is appropriate. | 22938492 |
| B-Cell Lymphomas | Stem Cell Exhaustion | Phase II trial of 131-Iodine tositumomab with high-dose chemotherapy and autologous stem cell transplantation for relapsed diffuse large B cell lymphoma. | 22940055 |
| Primary Cutaneous B-Cell Non-Hodgkin Lymphoma, Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | The purpose of this study was to evaluate the standard outpatient dose of 131-Iodine tositumomab (75 cGy) combined with high-dose carmustine, etoposide, cytarabine, and melphalan (BEAM) followed by autologous stem cell rescue for the treatment of chemotherapy-sensitive relapsed or refractory, or high-risk first complete remission (CR) patients with diffuse large B cell non-Hodgkin's lymphoma (DLBCL). | 22940055 |
| Wernicke Encephalopathy, Upbeat central vestibular nystagmus, Leukemia, Myelocytic, Acute, Nystagmus, End-Position | Stem Cell Exhaustion | A 33-year-old woman with Wernicke's encephalopathy (WE) due to poor oral intake after allogeneic stem cell transplantation for acute myeloid leukemia showed a sequential development of bilateral gaze-evoked nystagmus (GEN), rightward gaze palsy, and upbeat nystagmus. | 22940074 |
| Fatigue, Specialty Type - cancer | Stem Cell Exhaustion | Measurements included the Profile of Mood States fatigue scale, Functional Assessment of Cancer Therapy-Fatigue, ActiGraph(r) recordings, 6-Minute Walk Test, and hemoglobin levels at baseline and before and after stem cell collection. | 22940511 |
| Dilated Cardiomyopathy Pathway | Stem Cell Exhaustion | [Comparative study on the efficacy of intracoronary infusion with various types of autologous bone marrow stem cells for patients with dilated cardiomyopathy]. | 22943685 |
| Doctor of Chiropractic, Dilated Cardiomyopathy Pathway | Stem Cell Exhaustion | To compare the effects of intracoronary infusion of mononuclear stem cells (MNCs) or mesenchymal stem cells (MSCs) in patients with dilated cardiomyopathy (DCM). | 22943685 |
| Doctor of Chiropractic | Stem Cell Exhaustion | Intracoronary bone marrow stem cells transplantation is safe and effective for DCM patients while the efficacy of MSCs and MNCs transplantation is comparable. | 22943685 |
| Febrile Neutropenia | Stem Cell Exhaustion | Drug interactions between micafungin at high doses and cyclosporine A in febrile neutropenia patients after allogeneic hematopoietic stem cell transplantation. | 22943928 |
| Hemorrhagic cystitis | Stem Cell Exhaustion | Risk factors for and prognosis of hemorrhagic cystitis after allogeneic stem cell transplantation: retrospective analysis in a single institution. | 22944099 |
| CLTC gene, Hemorrhagic cystitis | Stem Cell Exhaustion | Hemorrhagic cystitis (HC) is a major complication after allogeneic stem cell transplantation (allo-SCT) and can be life threatening. | 22944099 |
| Papillary Renal Cell Carcinoma | Stem Cell Exhaustion | Expression of stem-cell markers OCT-4 and CD133: important prognostic factors in papillary renal cell carcinoma. | 22944295 |
| Papillary Renal Cell Carcinoma | Stem Cell Exhaustion | To the best of our knowledge, the prognostic significance of the expression of stem cell markers, OCT-4 and CD133, has not yet been studied in papillary renal cell carcinoma. | 22944295 |
| Papillary Renal Cell Carcinoma | Stem Cell Exhaustion | These results showed that the expression of stem cell markers, OCT-4 and CD133, may serve, respectively, as a poor and favorable prognostic marker, in papillary renal cell carcinoma. | 22944295 |
| Neurotoxicity Syndromes, Impaired cognition | Stem Cell Exhaustion | Owing to its neurotoxicity, allogeneic hematopoietic stem cell transplantation (HSCT) carries risks for cognitive impairment. | 22945857 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | In this study, we report that leukemia stem cell function in xenotransplant models of acute myeloid leukemia (AML) depends on SIRPa-mediated inhibition of macrophages through engagement with its ligand CD47. | 22945919 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Disruption of SIRPa signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts. | 22945919 |
| Specialty Type - cancer, Neoplasms, Malignant Neoplasms, leukemia | Stem Cell Exhaustion | Moreover, the existence of subclonal genetic and functional diversity in some human cancers such as leukemia underscores the importance of defining tumor surveillance mechanisms that effectively target the disease-sustaining cancer stem cells in addition to bulk cells. | 22945919 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We generated mice expressing SIRPa variants with differential ability to bind human CD47 and demonstrated that macrophage-mediated phagocytosis and clearance of AML stem cells depend on absent SIRPa signaling. | 22945919 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Mesenchymal stem cells (MSCs) are self-renewing, multipotent cells that could potentially be used to repair injured cartilage in diseases such as osteoarthritis (OA). | 22947769 |
| Specialty Type - cancer, Pancreatic carcinoma | Stem Cell Exhaustion | Pancreatic carcinoma cell lines reflect frequency and variability of cancer stem cell markers in clinical tissue. | 22948659 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells (CSCs) are thought to be responsible for progression and therapy resistance. | 22948659 |
| Malignant Neoplasms | Stem Cell Exhaustion | Circulating endothelial progenitor cells (cEPCs) as recruited to the angiogenic vascular system of malignant tumors have been proposed as a biomarker in malignancies. | 22948772 |
| Myocardial Ischemia | Stem Cell Exhaustion | Mesenchymal stem cell (MSC) transplantation has been proposed as a potential therapeutic approach for ischemic heart disease, but the regenerative capacity of these cells decreases with age. | 22950427 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Tissue inhibitor of matrix metalloproteinase-3 or vascular endothelial growth factor transfection of aged human mesenchymal stem cells enhances cell therapy after myocardial infarction. | 22950427 |
| Inflammation, Metastatic hepatocellular carcinoma | Stem Cell Exhaustion | Mesenchymal stem cells in inflammation microenvironment accelerates hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition. | 22952657 |
| Tissue injury, Inflammation | Stem Cell Exhaustion | In response to inflammation, mesenchymal stem cells (MSCs) are known to migrate to tissue injury sites to participate in immune modulation, tissue remodeling and wound healing. | 22952657 |
| Disease, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Cytopenia, Hypercellular bone marrow | Stem Cell Exhaustion | Myelodysplastic syndromes (MDS) are clonal stem cell disorders which frequently show a hypercellular dysplastic bone marrow (BM) associated with inefficient hematopoiesis and peripheral cytopenias due to increased apoptosis and maturation blockades. | 22952954 |
| Toxic effect, Lymphoma | Stem Cell Exhaustion | This study aimed to evaluate the efficacy and toxicity of radioimmunotherapy (RIT) in recurrent lymphoma after hematopoietic stem cell transplantation (HSCT). | 22955069 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Extramedullary relapse of acute myeloid leukemia (AML) after stem-cell transplant is very rare and often remains a diagnostic challenge. | 22955081 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Long-term follow-up of reduced-intensity allogeneic stem cell transplantation for chronic lymphocytic leukemia: prognostic model to predict outcome. | 22955330 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Chronic lymphocytic leukemia (CLL) remains incurable with chemoimmunotherapy, and allogeneic hematopoietic stem cell transplantation (HSCT) offers the potential for cure. | 22955330 |
| Intermittent Claudication | Stem Cell Exhaustion | Exercise training in intermittent claudication: effects on antioxidant genes, inflammatory mediators and proangiogenic progenitor cells. | 22955572 |
| Malignant Glioma | Stem Cell Exhaustion | Increased age of transformed mouse neural progenitor/stem cells recapitulates age-dependent clinical features of human glioma malignancy. | 22958206 |
| Glioblastoma Multiforme Pathway, Malignant Glioma | Stem Cell Exhaustion | However, the adverse association of clinical course with aging is rarely considered in animal glioma models, impeding delineation of the relative importance of organismal versus progenitor cell aging in the genesis of glioma malignancy. | 22958206 |
| Glioma, Malignant Glioma | Stem Cell Exhaustion | Our study provides strong evidence that progenitor cell aging is responsible for promoting the hallmarks of age-dependent glioma malignancy and that consideration of progenitor aging will facilitate development of physiologically and clinically relevant animal models of human gliomas. | 22958206 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | To address this limitation, we implanted transformed neural stem/progenitor cells (NSPCs), the presumed cells of glioma origin, from 3- and 18-month-old mice into 3- and 20-month host animals. | 22958206 |
| Glioblastoma Multiforme Pathway, Hypoxia | Stem Cell Exhaustion | Greater tolerance to hypoxia in older progenitor cells, as evidenced by elevated HIF-1 promoter reporter activity and hypoxia response gene (HRG) expression, mirrors the upregulation of HRGs in cohorts of older vs. younger glioma patients revealed by analysis of gene expression databases, suggesting that differential response to hypoxic stress may underlie age-dependent differences in invasion, genomic instability, and treatment resistance. | 22958206 |
| Mucositis following radiation therapy | Stem Cell Exhaustion | mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis. | 22958932 |
| Mucositis following radiation therapy | Stem Cell Exhaustion | mTOR inhibition also protects from the loss of proliferative basal epithelial stem cells upon ionizing radiation in vivo, thereby preserving the integrity of the oral mucosa and protecting from radiation-induced mucositis. | 22958932 |
| leukemia | Stem Cell Exhaustion | Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression. | 22958933 |
| Neoplasms | Stem Cell Exhaustion | Developmental changes in key signaling pathways therefore confer temporal changes upon stem cell self-renewal and tumor suppressor mechanisms. | 22958933 |
| Pneumonitis, CTCAE | Stem Cell Exhaustion | Pneumonitis post-haematopoeitic stem cell transplant - cytopathology clinches diagnosis. | 22959064 |
| CLTC gene, Cystitis | Stem Cell Exhaustion | BKV reactivation is implicated in late onset haemorrhagic cystitis (HC) post Haematopoietic Stem Cell Transplant (HSCT). | 22959064 |
| Neoplasms | Stem Cell Exhaustion | Notably, INK4-ARF is actively silenced en bloc in embryonic, fetal, and adult stem cells but becomes poised to respond to oncogenic stress signals as stem cells lose their self-renewal capacity and differentiate, thereby providing a potent barrier to tumor formation. | 22960768 |
| Hodgkin Disease, Failure | Stem Cell Exhaustion | FDA granted accelerated approval of brentuximab vedotin for the treatment of patients with Hodgkin lymphoma after failure of autologous stem cell transplantation (ASCT) or after failure of at least two prior multiagent chemotherapy regimens in patients who are not ASCT candidates, and for the treatment of patients with sALCL after failure of at least one prior multiagent chemotherapy regimen. | 22962441 |
| Colorectal Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Expression levels of CD133, a cancer stem cell marker, and of the a-subunit of the dystroglycan (a-DG) complex, have been previously reported to be altered in colorectal cancers. | 22964035 |
| Rhinosinusitis | Stem Cell Exhaustion | Hematopoietic stem cell transplantation and rhinosinusitis: the utility of screening sinus computed tomography. | 22965703 |
| Lupus Erythematosus, Systemic | Stem Cell Exhaustion | Gene expression profile reveals abnormalities of multiple signaling pathways in mesenchymal stem cell derived from patients with systemic lupus erythematosus. | 22966240 |
| Lupus Erythematosus, Encephalitis, St. Louis | Stem Cell Exhaustion | We aimed to compare bone-marrow-derived mesenchymal stem cells (BMMSCs) between systemic lupus erythematosus (SLE) and normal controls by means of cDNA microarray, immunohistochemistry, immunofluorescence, and immunoblotting. | 22966240 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | Early onset MDS present markedly decreased hematopoietic progenitor cells (HPC), and particularly in erythroid progenitors extensively and severely. | 22967409 |
| HER2-positive carcinoma of breast | Stem Cell Exhaustion | Epithelial-mesenchymal transition and stem cell markers in patients with HER2-positive metastatic breast cancer. | 22973057 |
| mecarzole, Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | In this prospective study, we assessed the gene transcripts of epithelial-to-mesenchymal transition-inducing transcription factors (EMT-TF) and cancer stem cell (CSC) features in patients with HER2(+) metastatic breast cancer (MBC). | 22973057 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | The incorporation of high-dose therapy/autologous stem cell transplantation (HDT/ASCT) and novel agents has significantly improved survival in patients with multiple myeloma (MM), but whether this improvement also benefits patients harboring poor prognostic features, such as nonhyperdiploid MM (NH-MM) and a high proliferation index, remains largely unknown. | 22974582 |
| Osteosarcoma, Central neuroblastoma | Stem Cell Exhaustion | We present a case of chest wall osteosarcoma that developed in a 14-year-old boy 7 years after completion of chemotherapy, autologous peripheral blood stem cell transplantation, radiation, and resection for stage 3, high-risk neuroblastoma. | 22974636 |
| B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 | Stem Cell Exhaustion | The patient received allogenic peripheral blood stem cell transplantation from a haploidentical son against Philadelphia chromosome-positive acute lymphocytic leukemia. | 22975560 |
| Senile cardiac amyloidosis | Stem Cell Exhaustion | [Clinical analysis of autologous stem cell transplantation for nine cases of cardiac amyloidosis]. | 22975774 |
| Treatment related secondary malignancy, Amyloidosis | Stem Cell Exhaustion | High-dose melphalan (MEL) with stem cell transplantation (HDM/SCT) is an effective treatment for AL amyloidosis, but patients with cardiac involvement are ineligible because of high therapy-related mortality. | 22975774 |
| Encephalopathy, CTCAE 5.0, Brain Abscess, Toxoplasmosis | Stem Cell Exhaustion | Toxoplasmosis after allogeneic hematopoietic stem cell transplantation (HSCT) generally manifests as encephalopathy or brain abscess; however, disseminated disease has been sporadically reported. | 22975819 |
| TCL4 gene, Pustulosis of Palms and Soles | Stem Cell Exhaustion | [Alleviation of palmoplantar pustulosis associated with adult T cell leukemia/lymphoma after allogeneic hematopoietic stem cell transplantation]. | 22975820 |
| Adult T-Cell Lymphoma/Leukemia | Stem Cell Exhaustion | For ATLL in partial remission, we performed allogeneic peripheral blood stem cell transplantation (allo-PBSCT) from a related donor (HTLV-1-negative) with a conditioning regimen consisting of fludarabine, melphalan, and total body irradiation with 3 Gy in February, 2010. | 22975820 |
| Aplastic Anemia | Stem Cell Exhaustion | Outcome of allogeneic haematopoietic stem cell transplantation in aplastic anaemia. | 22980607 |
| Aplastic Anemia | Stem Cell Exhaustion | To analyze factors associated with survival, rejection and graft versus host disease in aplastic anaemia patients undergoing allogeneic haematopoietic stem cell transplantation (SCT) from HLA matched sibling donors. | 22980607 |
| Aplastic Anemia | Stem Cell Exhaustion | Consecutive aplastic anaemia (AA) patients undergoing haematopoietic stem cell transplantation from HLA-matched sibling donors at this centre were included in this study. | 22980607 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | Finally, xenotransplantation of human induced pluripotent stem cells, ovarian cancer cells, and hepatocytes shows that SCID and FSG rats can act as hosts for xenogeneic tissue grafts and stem cell transplantation and may be useful for preclinical testing of new drugs. | 22981234 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Superior long-term outcome of patients with early transformation of non-Hodgkin lymphoma undergoing stem cell transplantation. | 22981964 |
| Vascular System Injuries | Stem Cell Exhaustion | Respective abundance of circulating endothelial cells (CEC) and endothelial progenitor cells (EPC) might reflect the balance between vascular injury and repair and potentially serve as biomarkers of the disease. | 22983452 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Plerixafor and granulocyte colony-stimulating factor for first-line steady-state autologous peripheral blood stem cell mobilization in lymphoma and multiple myeloma: results of the prospective PREDICT trial. | 22983579 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | In Europe, the combination of plerixafor + granulocyte colony-stimulating factor is approved for the mobilization of hematopoietic stem cells for autologous transplantation in patients with lymphoma and myeloma whose cells mobilize poorly. | 22983579 |
| Hodgkin Disease, Lymphoma, Non-Hodgkin, Multiple Myeloma | Stem Cell Exhaustion | The combination of plerixafor + granulocyte colony-stimulating factor was used to mobilize hematopoietic stem cells in 118 patients (90 with myeloma, 25 with non-Hodgkin's lymphoma, 3 with Hodgkin's disease). | 22983579 |
| Lymphoma, Non-Hodgkin, Toxic effect, Multiple Myeloma | Stem Cell Exhaustion | In this prospective, multicenter European study, mobilization with plerixafor + granulocyte colony-stimulating factor allowed the majority of patients with myeloma or non-Hodgkin's lymphoma to undergo transplantation with minimal toxicity, providing further data supporting the safety and efficacy of plerixafor + granulocyte colony-stimulating factor for front-line mobilization of hematopoietic stem cells in patients with non-Hodgkin's lymphoma or myeloma. | 22983579 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Influence of molecular subgroups on outcome of acute myeloid leukemia with normal karyotype in 141 patients undergoing salvage allogeneic stem cell transplantation in primary induction failure or beyond first relapse. | 22983588 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | To evaluate the role of molecular subgroups of acute myeloid leukemia with normal karyotype after allogeneic stem cell transplantation beyond first complete remission, we analyzed the data from 141 consecutive adults (median age: 51.0 years, range 18.4-69.3 years) who had received an allogeneic transplant either in primary induction failure or beyond first complete remission. | 22983588 |
| Ischemic stroke | Stem Cell Exhaustion | In order to detect possible neural stem or progenitor cells in CVOs of the human brain, we analysed post mortem human brain tissue from patients without neuropathological changes (n = 16) and brains from patients with ischaemic stroke (n = 16). | 22985410 |
| Neoplasms, Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | Transcription factors associated with epithelial-mesenchymal transition and cancer stem cells in the tumor centre and margin of invasive breast cancer. | 22985790 |
| Specialty Type - cancer | Stem Cell Exhaustion | Recently, features of EMT were shown to be linked to cells with tumor-founding capability, so- called cancer stem cells (CSC). | 22985790 |
| Hyperglycemia, Acute GVH disease | Stem Cell Exhaustion | Severe hyperglycemia immediately after allogeneic hematopoietic stem-cell transplantation is predictive of acute graft-versus-host disease. | 22987342 |
| Graft-vs-Host Disease, Hyperglycemia, Acute GVH disease | Stem Cell Exhaustion | Stress hyperglycemia and acute graft-versus-host disease (GVHD), the major early complication of hematopoietic stem cell transplantation (HSCT), are both associated with excessive release of inflammatory cytokines. | 22987342 |
| Acute leukemia | Stem Cell Exhaustion | We studied nondiabetic adult recipients of human leukocyte antigen-matched HSCT (peripheral blood stem cells) for acute leukemia. | 22987342 |
| Multiple Myeloma | Stem Cell Exhaustion | The introduction of novel agents (thalidomide, bortezomib and lenalidomide) in the frontline therapy of multiple myeloma has markedly improved the outcome both in younger patients who are candidates for high-dose therapy plus autologous stem-cell transplantation (HDT/ASCT) and in elderly patients. | 22987987 |
| Neoplasms, Malignant neoplasm of ovary, Specialty Type - cancer, ovarian neoplasm | Stem Cell Exhaustion | We investigated plasma levels of selected hematopoietic cytokines: stem cell factor (SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), and macrophage colony-stimulating factor (M-CSF) and the tumor marker cancer antigen (CA 125) in epithelial ovarian cancer patients as compared with control groups: benign ovarian tumor patients (cysts) and healthy subjects. | 22988839 |
| Lymphohistiocytosis, Hemophagocytic | Stem Cell Exhaustion | Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis. | 22990013 |
| Lymphohistiocytosis, Hemophagocytic | Stem Cell Exhaustion | Hemophagocytic lymphohistiocytosis (HLH) is characterized by deregulated engulfment of hematopoietic stem cells (HSCs) by BM macrophages, which are activated presumably by systemic inflammatory hypercytokinemia. | 22990013 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | MRI-based liver iron content predicts for nonrelapse mortality in MDS and AML patients undergoing allogeneic stem cell transplantation. | 22991415 |
| Liver carcinoma, Specialty Type - cancer, Hollings Cancer Center | Stem Cell Exhaustion | Epithelial cell adhesion molecule (EpCAM) has been proposed as a marker for cancer stem cells in human hepatocellular carcinoma (HCC). | 22993038 |
| Neoplasms | Stem Cell Exhaustion | In this Opinion article, we discuss recent reports that suggest unique and only partially understood mechanisms behind this paradox, including tumour repression, anti-angiogenic effects and stem cell ageing and availability. | 22996602 |
| Pneumonia | Stem Cell Exhaustion | Fatal BK virus pneumonia following stem cell transplantation. | 22998078 |
| Pneumonia, Acute lymphocytic leukemia | Stem Cell Exhaustion | We report the case of a 39-year-old male patient who died of severe BK virus (BKV) pneumonia 168 days after hematopoietic stem cell transplantation (HSCT) for acute lymphoblastic leukemia. | 22998078 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | The number of circulating endothelial progenitor cells (EPCs) is considered to be a surrogate marker for coronary artery disease (CAD). | 23000960 |
| Ocular surface disease | Stem Cell Exhaustion | A 9-year-old girl with severe unilateral ocular surface disease due to limbal stem cell deficiency following chemical injury underwent autologous cultivated limbal epithelial transplantation (CLET) twice in her right eye that failed to improve the condition of the ocular surface. | 23001100 |
| Communicable Diseases | Stem Cell Exhaustion | Increased infection rate after preemptive rituximab treatment for Epstein-Barr virus reactivation after allogeneic hematopoietic stem-cell transplantation. | 23001354 |
| Lymphoproliferative Disorders, Immunologic Deficiency Syndromes | Stem Cell Exhaustion | Preemptive rituximab (R) treatment decreases the incidence of Epstein-Barr virus (EBV) posttransplantation lymphoproliferative disease, but the extent of immune deficiency related to R in patients who received allogeneic hematopoietic stem-cell transplantation is unclear. | 23001354 |
| Acute GVH disease | Stem Cell Exhaustion | Fifty-two of them could be matched with controls (not receiving R) according to administration of antithymoglobulin, stem-cell source and donor type, age and grade of acute graft-versus-host disease. | 23001354 |
| Multiple Organ Failure | Stem Cell Exhaustion | HLH may be cured by immunosuppressive therapy and eventual stem cell transplantation but rapid disease progression to multi-organ failure results in a high mortality. | 23005894 |
| T-Cell Prolymphocytic Leukemia | Stem Cell Exhaustion | In this paper, we report a case of a 61-year-old female who underwent nonmyeloablative allogenic stem cell transplantation for T-cell prolymphocytic leukemia and subsequently developed biopsy proven minimal change disease shortly after cessation of her immunosuppression therapy. | 23006339 |
| Multiple Myeloma | Stem Cell Exhaustion | Serologic response to a 23-valent pneumococcal vaccine administered prior to autologous stem cell transplantation in patients with multiple myeloma. | 23009118 |
| Multiple Myeloma | Stem Cell Exhaustion | We retrospectively investigated the response of a 23-valent polysaccharide-based pneumococcal vaccine in 60 patients with multiple myeloma administered prior to autologous stem cell transplantation (ASCT). | 23009118 |
| Chronic granulomatous disease | Stem Cell Exhaustion | Health related quality of life and emotional health in children with chronic granulomatous disease: a comparison of those managed conservatively with those that have undergone haematopoietic stem cell transplant. | 23011479 |
| Chronic granulomatous disease | Stem Cell Exhaustion | Haematopoietic stem cell transplant (HSCT) can cure CGD. | 23011479 |
| Play, Communicable Diseases | Stem Cell Exhaustion | Delays in immune recovery after allogeneic hematopoietic stem cell transplantation (allo-HSCT) are associated with increased risks of infection and relapse. | 23012326 |
| BCR gene, Leukemia, Myelocytic, Acute, Multiple Myeloma, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Five patients (2 AML, 1 ALL, 1 accelerated-phase CML, and 1 myeloma) were treated with autologous or allogeneic stem-cell transplantation. | 23014520 |
| Amyloidosis | Stem Cell Exhaustion | Bortezomib and dexamethasone consolidation following risk-adapted melphalan and stem cell transplantation for patients with newly diagnosed light-chain amyloidosis. | 23014566 |
| Prediabetes syndrome, diabetic | Stem Cell Exhaustion | Patients with an HbA1c in the prediabetic and diabetic range have higher numbers of circulating cells with osteogenic and endothelial progenitor cell markers. | 23015657 |
| Vascular calcification, Disorder of eye due to diabetes mellitus | Stem Cell Exhaustion | Vascular calcification, an important feature of diabetic vasculopathy, is an active process potentially mediated by endothelial progenitor cells (EPCs) coexpressing the osteoblastic marker osteocalcin (OCN). | 23015657 |
| Skin Erosion | Stem Cell Exhaustion | To change the current amelioration of disease into a full cure, we propose to (i) increase safety as well as efficacy of haematopoietic cell transplant (HCT) using co-infusion of mesenchymal stromal/stem cells with haematopoietic stem cells and non-myeloablative conditioning for transplant; (ii) optimize homing of donor cells into the skin erosions in animal models of EB; and (iii) discover and test new drugs for EB therapy using patient-specific induced pluripotent stem cells. | 23016552 |
| Inflammation, Coronary Arteriosclerosis | Stem Cell Exhaustion | Inflammation and circulating endothelial progenitor cells in patients with coronary artery disease and residual platelet reactivity. | 23018312 |
| Ischemia | Stem Cell Exhaustion | A long-term outcome of therapeutic angiogenesis by transplantation of peripheral blood stem cells in critical limb ischemia after interventional revascularization. | 23019056 |
| Myeloid-Lymphoid Leukemia Protein | Stem Cell Exhaustion | Our data demonstrate that NPM1-mutated CN-AML originates in an early stem cell with both lymphoid and myeloid differentiation potential. | 23020761 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Donor lymphocyte infusions (DLI) can induce remission in patients with hematologic malignancies who relapse after allogeneic stem cell transplantation. | 23022128 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Association of disparities in known minor histocompatibility antigens with relapse-free survival and graft-versus-host disease after allogeneic stem cell transplantation. | 23022467 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Allogeneic stem cell transplantation (allo-SCT) can induce remission in patients with hematologic malignancies due to graft-versus-tumor (GVT) responses. | 23022467 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cell behavior is thought to be largely determined by intrinsic properties and by regulatory signals provided by the microenvironment. | 23023702 |
| Hematopoietic Neoplasms, Primary Myelofibrosis | Stem Cell Exhaustion | Spleens of myelofibrosis patients contain malignant hematopoietic stem cells. | 23023702 |
| Neuronal and mixed neuronal-glial tumor | Stem Cell Exhaustion | Olig2-positive cells in glioneuronal tumors show both glial and neuronal characters: the implication of a common progenitor cell? | 23025580 |
| Chordoma, Scoliosis, unspecified | Stem Cell Exhaustion | Non-DD cells were collected from 1 donor (scoliosis) and chordoma tissue was obtained from (positive control, stem cell markers) 2 donors. | 23025667 |
| Impaired T cell function | Stem Cell Exhaustion | The goal of this study was to uncover age-dependent mechanisms of stem cell dysfunction and to investigate possible means to restore the cellular function. | 23026201 |
| Graft-vs-Host Disease, Muscle Cramp, Neuropathy | Stem Cell Exhaustion | Muscle cramps and neuropathies in patients with allogeneic hematopoietic stem cell transplantation and graft-versus-host disease. | 23028681 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease (GVHD) is an immune-mediated multisystemic disorder and the leading cause of morbidity after allogeneic hematopoietic stem cell transplantation. | 23028681 |
| Muscle Cramp, Polyneuropathy | Stem Cell Exhaustion | Median onset of polyneuropathy and muscle cramps was 6 and 9 months after allogeneic hematopoietic stem cell transplantation, respectively. | 23028681 |
| Osteoporosis | Stem Cell Exhaustion | The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors. | 23028809 |
| Osteoporotic Fractures | Stem Cell Exhaustion | These candidate genes indicate intrinsic deficiencies in self-renewal and differentiation potential in osteoporotic stem cells. | 23028809 |
| Osteoporotic Fractures | Stem Cell Exhaustion | We also compared both hMSC-OP and non-osteoporotic hMSC-old of elderly donors to hMSC of ~30 years younger donors and found that the transcriptional changes acquired between the sixth and the ninth decade of life differed widely between osteoporotic and non-osteoporotic stem cells. | 23028809 |
| Neutropenia | Stem Cell Exhaustion | The use of intravenous antibiotics at the onset of neutropenia in patients receiving outpatient-based hematopoietic stem cell transplants. | 23029441 |
| Neutropenia, Bacterial Infections | Stem Cell Exhaustion | Empirical antibiotics at the onset of febrile neutropenia are one of several strategies for management of bacterial infections in patients undergoing Hematopoietic Stem Cell Transplant (HSCT) (empiric strategy). | 23029441 |
| PDX1 gene | Stem Cell Exhaustion | Differentiation of human adipose tissue-derived stem cells into aggregates of insulin-producing cells through the overexpression of pancreatic and duodenal homeobox gene-1. | 23031216 |
| Specialty Type - cancer | Stem Cell Exhaustion | Loss of p53 results in increased expression of CD44, a cancer stem cell (CSC) marker, which is involved in the scavenging of reactive oxygen species (ROS). | 23031740 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Longitudinal changes in body mass and composition in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem-cell transplantation. | 23032628 |
| Hematologic Neoplasms | Stem Cell Exhaustion | To measure longitudinal changes in body mass and composition in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem-cell transplantation (HSCT). | 23032628 |
| Malignant Neoplasms | Stem Cell Exhaustion | A quantitative Malignancy Index Diagnostic System (qMIDS) was developed based on 14 FOXM1 (isoform B)-associated genes implicated in the regulation of the cell cycle, differentiation, ageing, genomic stability, epigenetic and stem cell renewal, and two reference genes. | 23034676 |
| Myeloid neoplasm, Mycoses | Stem Cell Exhaustion | Granulocyte macrophage colony-stimulating factor in 66 patients with myeloid or lymphoid neoplasms and recipients of hematopoietic stem cell transplantation with invasive fungal disease. | 23038157 |
| Prostate carcinoma, Benign prostatic hypertrophy | Stem Cell Exhaustion | We isolated and characterized CD31(-)CD34(+)CD45(-)CD146(-) progenitor cells (adipose-derived stem cells [ASC]) in paired samples of PP and preperitoneal visceral adipose tissue from prostate tissue and peripheral blood mononuclear cells of prostate cancer and nodular prostatic hyperplasia patients. | 23038706 |
| Malignant neoplasm of prostate | Stem Cell Exhaustion | Concordantly, adipsin gene (CFD) expression, which is known to be up-regulated in adipose stem cells, was overexpressed in PP adipose tissue, in the prostate of cancer patients and in prostate CD31(-)CD34(+)CD45(-)CD146(-) sorted cells. | 23038706 |
| Prostate carcinoma | Stem Cell Exhaustion | While the role of periprostatic (PP) adipose tissue in prostate cancer progression has been barely appreciated, we sought to determine the progenitor cell population in PP adipose tissue and the association with prostate cancer. | 23038706 |
| Prostatic Neoplasms | Stem Cell Exhaustion | Human periprostatic white adipose tissue is rich in stromal progenitor cells and a potential source of prostate tumor stroma. | 23038706 |
| Neoplasms | Stem Cell Exhaustion | A body of growing evidence now implicates white adipose tissue as a relevant source of stromal progenitor cells recruited to the tumor microenvironment to form supportive tumor stroma. | 23038706 |
| Prostatic Neoplasms | Stem Cell Exhaustion | Present findings indicate that PP adipose tissue is a reservoir of progenitor cells with the potential to migrate towards prostate tumors, although its clinical significance merits further evaluation. | 23038706 |
| Multiple Myeloma | Stem Cell Exhaustion | [Effect of bortezomib on the efficiency of hematopoietic stem cell mobilization in patients with multiple myeloma]. | 23038970 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | To study the results of mobilizing and collecting autologous hematopoietic stem cells (HSC) in patients with multiple myeloma (MM) receiving bortezomib as part of induction therapy regimens. | 23038970 |
| Mycoses | Stem Cell Exhaustion | [Invasive mycoses during hematopoietic stem cell transplantation]. | 23038972 |
| Mycoses | Stem Cell Exhaustion | To define the frequency, etiology, and risk factors of invasive mycoses (IM) in patients with allogeneic (allo) and autologous (auto) hematopoietic stem cell transplantation (HSCT) and to evaluate the impact of IM on overall survival (OS). | 23038972 |
| Sepsis, Neutropenia, Lymphopenia, Infection, Gastrointestinal mucositis, Graft vs Host Reaction, Acute lymphocytic leukemia | Stem Cell Exhaustion | Its risk factors are acute lymphoblastic leukemia; non-myeloablative conditioning regimen; use of fludarabine and antilymphocyte globulin; peripheral blood stem cells as a source for grafting; long-term lymphopenia, neutropenia; use of granulocyte colony-stimulating factor (G-CSF); acute graft-versus-host reaction; grade 3-4 mucositis; infections, such as cytomegalovirus, sepsis. | 23038972 |
| palladium | Stem Cell Exhaustion | This study is the first to test stem cell therapy in an animal model of PD. | 23040209 |
| Fibrosis Assessment, Peyronie Disease | Stem Cell Exhaustion | Intratunical injection of human adipose tissue-derived stem cells prevents fibrosis and is associated with improved erectile function in a rat model of Peyronie's disease. | 23040209 |
| palladium, Elastoid degeneration, Fibrosis Assessment | Stem Cell Exhaustion | To test the effects of a local injection of adipose tissue-derived stem cells (ADSCs) in the active phase of a rat model of PD on the subsequent development of fibrosis and elastosis of the TA and underlying erectile tissue. | 23040209 |
| Central neuroblastoma | Stem Cell Exhaustion | We describe a case of a 5-year-old girl with central nervous system relapse of neuroblastoma after high-dose chemotherapy and autologous stem cell transplantation. | 23042021 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Established breast cancer stem cell markers do not correlate with in vivo tumorigenicity of tumor-initiating cells. | 23042145 |
| Decompensated cirrhosis of liver | Stem Cell Exhaustion | [Prospective controlled trial of safety of human umbilical cord derived-mesenchymal stem cell transplantation in patients with decompensated liver cirrhosis]. | 23044231 |
| Decompensated cirrhosis of liver | Stem Cell Exhaustion | To evaluate the safety of human umbilical cord derived-mesenchymal stem cell (UC-MSC) transplantation therapy in patients with decompensated liver cirrhosis. | 23044231 |
| Exanthema, Ulcer, Herpes zoster disease | Stem Cell Exhaustion | Disseminated zoster presenting as gastric ulcers in the absence of the classic rash is unusual but has been reported in immunosuppressed patients with a history of bone marrow and stem cell transplant. | 23045567 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | HLA-mismatched stem-cell microtransplantation as postremission therapy for acute myeloid leukemia: long-term follow-up. | 23045576 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Whether HLA-mismatched stem-cell microtransplantation as a novel postremission therapy in these patients will improve survival and avoid graft-versus-host disease (GVHD) is still unknown. | 23045576 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | One hundred one patients with AML-CR1 (9 to 65 years old) from four treatment centers received programmed infusions of G-CSF-mobilized HLA-mismatched donor peripheral-blood stem cells after each of three cycles of high-dose cytarabine conditioning without GVHD prophylaxis. | 23045576 |
| Multiple Myeloma, Lymphoma, Non-Hodgkin, Chronic leukemia (category), Medicine, Non-Malignant Disease, Acute leukemia | Stem Cell Exhaustion | Participants mean age at hematopoietic stem cell-transplantation was 42 (range 1 to 72) years; there were 69 males and 47 females; 30 patients had multiple myeloma; 41 had non-Hodgkin and Hodgkin's lymphomas; 22 had acute leukemia; 6 had chronic leukemia; and 17 had non-malignant disease. | 23045832 |
| Paroxysmal nocturnal hemoglobinuria, Bone marrow hypocellularity, Hemoglobinuria, CTCAE 3.0, Anemia, Hemolytic | Stem Cell Exhaustion | Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal, hematopoietic stem cell disorder that manifests with hemolytic anemia and bone marrow failure. | 23046169 |
| Malignant neoplasm of esophagus | Stem Cell Exhaustion | The oncoprotein and stem cell renewal factor BMI1 associates with poor clinical outcome in oesophageal cancer patients undergoing preoperative chemoradiotherapy. | 23046527 |
| Specialty Type - cancer | Stem Cell Exhaustion | The polycomb group (PcG) family BMI1, acting downstream of the hedgehog (Hh) pathway, plays an essential role in the self-renewal of haematopoietic, neural, and intestinal stem cells, and is dysregulated in many types of cancer. | 23046527 |
| Specialty Type - cancer | Stem Cell Exhaustion | These findings suggest that BMI1 signal activation might be involved in promoting cancer regrowth and progression after CRT, and might be indicative of emergence of 'more aggressive' cancer progenitor cells. | 23046527 |
| Childhood Breast Carcinoma, Secondary Neoplasm | Stem Cell Exhaustion | Relationship of CD44+CD24-/low breast cancer stem cells and axillary lymph node metastasis. | 23046710 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Breast cancer stem cells, identified on the basis of CD44+CD24-/low expression, are associated with metastases and drug resistance. | 23046710 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | It is therefore important to investigate the proportion of CD44+CD24-/low breast cancer stem cells for the diagnosis of metastases in axillary nodes. | 23046710 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | CD44+CD24-/low breast cancer stem cells might help clinicians to determine the presence of LN metastases. | 23046710 |
| Multiple Myeloma, Atrial Fibrillation by ECG Finding | Stem Cell Exhaustion | Atrial fibrillation following autologous stem cell transplantation in patients with multiple myeloma: incidence and risk factors. | 23047326 |
| Atrial Fibrillation, Multiple Myeloma, Atrial Fibrillation by ECG Finding | Stem Cell Exhaustion | Atrial fibrillation (AF) often develops in patients with multiple myeloma following autologous stem cell transplantation (ASCT), but the exact incidence of, and the risk factors for AF have not been described. | 23047326 |
| Neoplasms | Stem Cell Exhaustion | Endothelial progenitor cells (EPCs) may be recruited from bone marrow to sustain tumor vascularisation and promote the metastatic switch. | 23049731 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | We hypothesized that a cancer stem cell marker may identify NAC-resistant patients, and evaluated CD133 and ALDH1 as a potential surrogate marker for breast cancer. | 23049880 |
| Urinary Stress Incontinence | Stem Cell Exhaustion | We examined the effect of myostatin and myostatin inhibition by an antagonistic agent, follistatin, on growth of human urethral rhabdosphincter satellite cells (muscle stem cells) to develop a new strategy for treatment of stress urinary incontinence. | 23050675 |
| Inflammation, Communicable Diseases | Stem Cell Exhaustion | Tb4 likely acts to repair and regenerate wounds by promoting cell migration and stem cell mobilization and differentiation, and by inhibiting inflammation, apoptosis, and infection. | 23050815 |
| Lung Injury | Stem Cell Exhaustion | Amelioration of paraquat-induced pulmonary injury by mesenchymal stem cells. | 23051186 |
| Cerebral hypomyelination | Stem Cell Exhaustion | Human central nervous system stem cells (HuCNS-SCs) can develop into oligodendrocytes and confer structurally normal myelin when transplanted into a hypomyelinating mouse model. | 23052294 |
| Malignant tumor of colon, Neoplasms | Stem Cell Exhaustion | A tumor hypoxic niche protects human colon cancer stem cells from chemotherapy. | 23052691 |
| Specialty Type - cancer, Hypoxia | Stem Cell Exhaustion | Hypoxia has been found to play an important role in regulating the biological characteristics of cancer stem cells (cCSCs). | 23052691 |
| Venoocclusive disease | Stem Cell Exhaustion | Four patients conducted HDC with stem cell rescue after CIRT and 1 patient suffered from veno-occlusive disease just after HDC. | 23053401 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | Cancer stem cell markers are associated with adverse biomarker profiles and molecular subtypes of breast cancer. | 23053657 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | Cumulative evidence has demonstrated the presence of cancer stem cells (CSC) in breast cancer and its putative role in cancer progression. | 23053657 |
| Lymphoma | Stem Cell Exhaustion | Safety and feasibility of high-dose ranimustine (MCNU), carboplatin, etoposide, and cyclophosphamide (MCVC) therapy followed by autologous stem cell transplantation for malignant lymphoma. | 23054649 |
| Lymphoma | Stem Cell Exhaustion | High-dose chemotherapy followed by autologous stem cell transplantation (auto-SCT) is widely used as a salvage therapy in the treatment of refractory malignant lymphoma. | 23054649 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The patient was treated with standard AML chemotherapy and autologous peripheral blood stem cell transplantation. | 23054652 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | Cancer stem cell-related gene periostin: a novel prognostic marker for breast cancer. | 23056395 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | We investigated the expression status of periostin in breast cancer stem cells and its clinical implications in order to lay a foundation for managing breast cancer. | 23056395 |
| Up | Stem Cell Exhaustion | Subsequent comparison of selective epithelial, mesenchymal and cancer stem cell (CSC) markers between AD and NAD populations of CN and CR patients demonstrated an enhanced trend in mRNA expression of E-cadherin, EpCAM, STAT3 and Oct4 in the NAD population of CR patients. | 23056490 |
| Up | Stem Cell Exhaustion | AD cells from both CN and CR patients exhibited mesenchymal morphology with an antigen profile of mesenchymal stem cells and fibroblasts. | 23056490 |
| Inflammation, Cerebrovascular accident | Stem Cell Exhaustion | Clinical stroke trials with stem cell-based approaches aiming for trophic actions, modulation of inflammation and neuroprotection are ongoing. | 23057628 |
| Micropapillary carcinoma, Colorectal Carcinoma, Neoplasms | Stem Cell Exhaustion | We hypothesized that the aggressive features of micropapillary carcinoma might be related to the presence of more tumor cells with stem cell phenotype in colorectal cancer. | 23060121 |
| Micropapillary carcinoma, Carcinoma, Papillary | Stem Cell Exhaustion | We compared the clinicopathological characteristics, including survival data and immunohistochemical profiles of stem cell markers (SOX2, NOTCH3, CD44v6, CD166, ALDH1) of micropapillary carcinomas with those of randomly selected 112 conventional adenocarcinomas lacking micropapillary carcinoma components (non-micropapillary carcinoma) in the colorectum. | 23060121 |
| Micropapillary carcinoma, Carcinoma, Papillary, Specialty Type - cancer | Stem Cell Exhaustion | We also found a higher expression rate of cancer stem cell markers in micropapillary carcinomas, suggesting their potential contribution to the survival disadvantage of micropapillary carcinoma. | 23060121 |
| Colorectal Micropapillary Adenocarcinoma | Stem Cell Exhaustion | Colorectal micropapillary carcinomas are associated with poor prognosis and enriched in markers of stem cells. | 23060121 |
| Kidney Neoplasm | Stem Cell Exhaustion | Evaluation of the KIT/stem cell factor axis in renal tumours. | 23060556 |
| Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | To investigate the expression of the KIT/stem cell factor (SCF) axis in different renal cell carcinoma subtypes with regard to targeted therapies. | 23060556 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | We conclude that the GemOD regimen can be administered safely and effectively in elderly patients with relapsed and refractory PTCL who are ineligible for high dose chemotherapy with stem cell transplant. | 23061678 |
| Aggressive Adult Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Iodine-131 rituximab radioimmunotherapy with BEAM conditioning and autologous stem cell transplant salvage therapy for relapsed/refractory aggressive non-Hodgkin lymphoma. | 23062193 |
| Lymphoma, Non-Hodgkin, Familial, Aggressive Adult Non-Hodgkin Lymphoma | Stem Cell Exhaustion | A standard salvage therapy of relapsed/refractory aggressive non-Hodgkin lymphoma (NHL) comprises autologous stem cell transplantation (ASCT) after chemotherapy conditioning with carmustine, etoposide, cytarabine, and melphalan (BEAM) regimen. | 23062193 |
| Aortic valve calcification | Stem Cell Exhaustion | Role of circulating osteogenic progenitor cells in calcific aortic stenosis. | 23062532 |
| Aortic valve calcification | Stem Cell Exhaustion | The purpose of this study was to determine the role of circulating endothelial progenitor cells with osteoblastic phenotype (EPC-OCN) in human aortic valve calcification (AVC). | 23062532 |
| physiopathological, Wounds and Injuries | Stem Cell Exhaustion | Bone marrow dysfunction is common in severely injured trauma patients, with release of hematopoietic progenitor cells (HPC) into the peripheral blood. | 23063381 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Complete remission following chemotherapy with low-dose cytosine arabinoside and macrophage colony-stimulating factor/granulocyte colony-stimulating factor in a patient with relapsed acute myeloid leukemia after stem cell transplantation. | 23064572 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The prognosis of patients who relapse with acute myeloid leukemia (AML) after undergoing stem cell transplantation (SCT) is poor. | 23064572 |
| Pneumonia, Viral, Toxoplasmosis, Acute lymphocytic leukemia | Stem Cell Exhaustion | Severe pulmonary toxoplasmosis mimicking viral pneumonitis after a third allogeneic stem cell transplantation in a man with acute lymphoblastic leukemia. | 23064573 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | A 22-year-old man with acute lymphoblastic leukemia underwent allogeneic stem cell transplantation (allo-SCT) twice, then underwent allo-SCT a third time due to relapse. | 23064573 |
| Specialty Type - cancer | Stem Cell Exhaustion | Thus, the mechanisms of cell division of ACD or symmetric cell division and centrosome inheritance are recapitulated in human cancer cells, and these findings may facilitate studies on cancer stem cells. | 23064640 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Extramedullary relapse of acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation: incidence, risk factors and outcomes. | 23065502 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Extramedullary relapse after allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia is a contributor to post-transplant mortality but risk factors for, and outcomes of, this condition are not well characterized. | 23065502 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We analyzed 257 consecutive patients undergoing allogeneic stem cell transplantation for acute myeloid leukemia at our institution to characterize extramedullary relapse, identify predictive variables and assess outcomes. | 23065502 |
| Hematologic Neoplasms | Stem Cell Exhaustion | We examined donor lymphocyte subset counts in relation to post-transplant lymphocyte recovery and transplant events in 220 consecutive myeloablative, T-cell-depleted, HLA-identical sibling hematopoietic stem cell transplant recipients with hematologic malignancies. | 23065508 |
| Chronic graft-versus-host disease | Stem Cell Exhaustion | In conclusion, these results identify donor immune characteristics that are associated with lymphocyte recovery, extensive chronic graft-versus-host disease, and survival in the recipient following allogeneic hematopoietic stem cell transplantation. | 23065508 |
| Mitochondrial Inheritance | Stem Cell Exhaustion | Overexpression of Bmi1 in granule cell progenitors (GCPs) led to a decrease in cerebellar size due to decreased GCP proliferation and repression of the expression of cyclin genes, whereas Bmi1 overexpression in postmitotic granule cells improved cell survival in response to stress by altering the expression of genes in the mitochondrial cell death pathway and of Myc and Lef-1. | 23065639 |
| Coma, Post-Head Injury | Stem Cell Exhaustion | Treatment of severe post-traumatic bone defects with autologous stem cells loaded on allogeneic scaffolds. | 23065806 |
| Hematological Disease | Stem Cell Exhaustion | PML primarily occurred not only in HIV-positive patients (33.3%) but also in patients with hematologic disorders after receiving stem cell transplantation, chemotherapy, and/or immunosuppressive treatment (39.6%). | 23066763 |
| Central neuroblastoma | Stem Cell Exhaustion | I-131-Metaiodobenzylguanidine therapy with allogeneic cord blood stem cell transplantation for recurrent neuroblastoma. | 23067429 |
| Central neuroblastoma | Stem Cell Exhaustion | Iodine-131-metaiodiobenzylguanidine (131I-MIBG) therapy combined with allogeneic cord blood stem cell transplantation (SCT) was used to treat a 4-year-old girl with recurrent neuroblastoma. | 23067429 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Poor glycaemic control in type 2 diabetes patients reduces endothelial progenitor cell number by influencing SIRT1 signalling via platelet-activating factor receptor activation. | 23070058 |
| Pancreatic Ductal Adenocarcinoma | Stem Cell Exhaustion | Expression of the stem cell markers CD133 and nestin in pancreatic ductal adenocarcinoma and clinical relevance. | 23071857 |
| Pancreatic Ductal Adenocarcinoma, Specialty Type - cancer, ANOPHTHALMIA AND PULMONARY HYPOPLASIA | Stem Cell Exhaustion | To evaluate the prognostic implication of cancer stem cell markers in pancreac ductal adenocarcinoma (PDAC), the expression of CD133 and nestin were investigated in a series of PDAC patients in relation to the survival rate. | 23071857 |
| Malignant Neoplasms | Stem Cell Exhaustion | CD133 expression is upregulated in PDAC that is related to poor prognosis, and treatment targeted the CD133 positive cancer/cancer stem cells might be a promising therapeutic strategy for this patients. | 23071857 |
| Morular Metaplasia of the Endometrium, Malignant Neoplasms, Multiple Myeloma | Stem Cell Exhaustion | Recent studies demonstrate an increased risk of second primary malignancies (SPMs) in patients with multiple myeloma (MM) receiving maintenance lenalidomide after autologous stem cell transplantation (ASCT). | 23073267 |
| Parkinson Disease | Stem Cell Exhaustion | Here we report on the generation of induced pluripotent stem cells (iPSCs) derived from Parkinson's disease patients and the implications of LRRK2(G2019S) mutation in human neural-stem-cell (NSC) populations. | 23075850 |
| Parkinson Disease | Stem Cell Exhaustion | Disease phenotypes were rescued by targeted correction of the LRRK2(G2019S) mutation with its wild-type counterpart in Parkinson's disease iPSCs and were recapitulated after targeted knock-in of the LRRK2(G2019S) mutation in human embryonic stem cells. | 23075850 |
| Keratinized squamous cell of esophagus | Stem Cell Exhaustion | By IHC, Bmi-1 was focally expressed in the basal layers of almost all esophageal squamous mucosa, which was similar to previous reports in other organs related to stem cells. | 23078618 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Outcome of relapse after allogeneic stem cell transplant in patients with acute myeloid leukemia. | 23082952 |
| Failure, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Although allogeneic stem cell transplant (Allo-SCT) is an effective treatment for high-risk acute myeloid leukemia (AML), relapses remain a major cause of treatment failure. | 23082952 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Our results suggest that for non-transplant patients, the tumor burden before treatment, perhaps reflecting cancer stem cell progeny/output, is an indirect measure that may indicate the number of MM cancer stem cells and hence event free survival. | 23083101 |
| Multiple Myeloma | Stem Cell Exhaustion | Autologous stem cell transplantation for multiple myeloma: identification of prognostic factors. | 23085487 |
| Heart failure, Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Percutaneous, transendocardial injection of bone marrow-derived mononuclear cells in heart failure patients following acute ST-elevation myocardial infarction: ALSTER-Stem Cell trial. | 23086792 |
| Infection | Stem Cell Exhaustion | Umbilical cord blood (UCB) stem cells are frequently employed for allogeneic stem cell transplant, but delayed myeloid and lymphoid immune reconstitution leads to increased risk of infections. | 23088744 |
| Kidney Neoplasm, Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | The mean circulating endothelial progenitor cell level in patients with renal cell carcinoma was 0.281%, significantly higher than in patients with benign renal tumors and healthy controls (0.073% and 0.076%, respectively, each p <0.001). | 23088990 |
| Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | The preoperative circulating endothelial progenitor cell level positively correlated with serum vascular endothelial growth factor in patients with renal cell carcinoma (r = 0.710, p <0.001). | 23088990 |
| Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | A high circulating endothelial progenitor cell level was found in patients with renal cell carcinoma, which positively correlated with serum vascular endothelial growth factor. | 23088990 |
| Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | High level of circulating endothelial progenitor cells positively correlates with serum vascular endothelial growth factor in patients with renal cell carcinoma. | 23088990 |
| Neoplasms, Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | Although accumulated evidence indicates that circulating endothelial progenitor cells contribute to tumor neovascularization, to our knowledge the level of these cells and its correlation with serum vascular endothelial growth factor in patients with renal cell carcinoma have not been studied. | 23088990 |
| Kidney Neoplasm, Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | The level of circulating endothelial progenitor cells (percent of total peripheral blood mononuclear cells) was quantified by assaying the CD45(-)CD34(+)vascular endothelial growth factor receptor 2(+) cell phenotype in 53 patients with renal cell carcinoma, 33 with benign renal tumors and 40 healthy controls. | 23088990 |
| Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | Results support the potential use of circulating endothelial progenitor cells as a novel biomarker for renal cell carcinoma. | 23088990 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Rituximab, fludarabine, and total body irradiation as conditioning regimen before allogeneic hematopoietic stem cell transplantation for advanced chronic lymphocytic leukemia: long-term prospective multicenter study. | 23089183 |
| Toxic effect, Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | To evaluate the efficacy and toxicity of reduced-intensity conditioning (RIC) combining fludarabine, low-dose total body irradiation (TBI) and rituximab before allogeneic hematopoietic stem cell transplantation (allo-HSCT) from human leucocyte antigen (HLA) identical siblings, we conducted a prospective study in patients <=65 years old with advanced chronic lymphocytic leukemia (CLL) stage B or C in response after a salvage treatment. | 23089183 |
| Neutropenia, Acute GVH disease | Stem Cell Exhaustion | Many days at home during neutropenia after allogeneic hematopoietic stem cell transplantation correlates with low incidence of acute graft-versus-host disease. | 23089563 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Single-molecule genomic data delineate patient-specific tumor profiles and cancer stem cell organization. | 23090114 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Substantial evidence supports the concept that cancers are organized in a cellular hierarchy with cancer stem cells (CSC) at the apex. | 23090114 |
| Aggressive Non-Hodgkin Lymphoma, B-Cell Lymphomas | Stem Cell Exhaustion | Rituximab maintenance therapy after autologous stem-cell transplantation in patients with relapsed CD20(+) diffuse large B-cell lymphoma: final analysis of the collaborative trial in relapsed aggressive lymphoma. | 23091101 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | The standard treatment for relapsed diffuse large B-cell lymphoma (DLBCL) is salvage chemotherapy followed by high-dose therapy and autologous stem-cell transplantation (ASCT). | 23091101 |
| Specialty Type - cancer | Stem Cell Exhaustion | LGR5 and Nanog were recently characterized as stem cell markers in various embryonic, adult and cancer stem cells. | 23092806 |
| Viremia | Stem Cell Exhaustion | Adenovirus viremia and disease: comparison of T cell-depleted and conventional hematopoietic stem cell transplantation recipients from a single institution. | 23092814 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | This investigation is the first attempt to correlate the gene expression profile of AURKA and AURKB in a cytogenetically stratified population of mesenchymal stem cells (MSCs) from MDS patients. | 23092930 |
| Specialty Type - cancer, Ovarian Serous Adenocarcinoma | Stem Cell Exhaustion | Prognostic impact of the cancer stem cell-related marker NANOG in ovarian serous carcinoma. | 23095773 |
| Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0 | Stem Cell Exhaustion | Paroxysmal nocturnal hemoglobinuria (PNH), a clonal hematopoietic stem cell disorder, manifests when the PNH clone populates in the hematopoietic compartment. | 23095789 |
| Malignant neoplasm of liver | Stem Cell Exhaustion | The stem cell E3-ligase Lin-41 promotes liver cancer progression through inhibition of microRNA-mediated gene silencing. | 23097274 |
| Neoplasms | Stem Cell Exhaustion | Lin-41 is a stem cell-specific E3 ligase and a known target of the tumour suppressor microRNA (miRNA) let-7. | 23097274 |
| Hindfoot (body structure) | Stem Cell Exhaustion | The present study reviewed the use of stem cell grafting in hindfoot and ankle surgery and the healing times in high-risk patients. | 23102874 |
| Neutropenia, Fever, Mycoses | Stem Cell Exhaustion | Our study highlights the potential success of a set of prevention measures mainly designed to reduce invasive environmental fungal infections in allogeneic hematopoietic stem cell transplant patients, in reducing fever and mortality among neutropenic cancer patients. | 23102987 |
| Osteoporosis | Stem Cell Exhaustion | The omega-6 arachidonic fatty acid, but not the omega-3 fatty acids, inhibits osteoblastogenesis and induces adipogenesis of human mesenchymal stem cells: potential implication in osteoporosis. | 23104199 |
| diabetic | Stem Cell Exhaustion | Recently, animal studies have demonstrated the efficacy of endothelial progenitor cell (EPC) therapy for diabetic wound healing. | 23107450 |
| Diabetes Mellitus | Stem Cell Exhaustion | Stem cell-based therapies have recently opened up new horizons for treatment of various types of diseases including diabetes mellitus. | 23109026 |
| diabetic | Stem Cell Exhaustion | Hereby, we aim to report the one-year follow-up results in the diabetic patients who underwent fetal liver-derived hematopoietic stem cell allotransplantation. | 23109026 |
| Hair follicle structure | Stem Cell Exhaustion | These observations are consistent with the role of the hair follicle as a major reservoir for progenitor cells. | 23110506 |
| Aggressive course, Carcinogenesis | Stem Cell Exhaustion | Furthermore, according to the stem-cell theory of carcinogenesis, aggressive tumors are characterized by an increase number of malignant stem-like cell population and their resistance to chemotherapy has been found to be mitochondrially driven. | 23111201 |
| Specialty Type - cancer, Carcinogenesis | Stem Cell Exhaustion | In case the hypothesis of stem-cell bioenergetic malformations' related carcinogenesis proves to be correct, it would contribute to the development of new prognostic, diagnostic and even more effective therapeutic interventions against various types of cancer. | 23111201 |
| Carcinogenesis | Stem Cell Exhaustion | Mitochondria malfunctions as mediators of stem-cells' related carcinogenesis: a hypothesis that supports the highly conserved profile of carcinogenesis. | 23111201 |
| Transcription Initiation | Stem Cell Exhaustion | Specifically, we support that mitochondrial and/or nuclear DNA alterations that control stem cells' ATP production drive stem cells to "immortalization" (Otto Warburg theory) that mediates cancer initiation and progression. | 23111201 |
| Hematologic Neoplasms, Mycoses | Stem Cell Exhaustion | Invasive fungal infection (IFI) causes morbidity and mortality among patients with hematological malignancies who receive cytotoxic chemotherapy or hematopoietic stem cell transplantation (HSCT). | 23111539 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Response to pretransplant hypomethylating agents influences the outcome of allogeneic hematopoietic stem cell transplantation in adults with myelodysplastic syndromes. | 23113470 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | [Expression of c-MPL in leukemic stem cells from acute myeloid leukemia patients]. | 23114117 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | This study was aimed to investigate the expression of c-MPL in acute myeloid leukemia (AML) and the correlation of the c-MPL expression with CD34 and CD38, so as to define the expression of c-MPL in leukemic stem cells. | 23114117 |
| Primary Myelofibrosis, Splenomegaly | Stem Cell Exhaustion | Splenic irradiation as a component of a reduced-intensity conditioning regimen for hematopoietic stem cell transplantation in myelofibrosis with massive splenomegaly. | 23117264 |
| Primary Myelofibrosis, Splenomegaly | Stem Cell Exhaustion | Although allogeneic hematopoietic stem cell transplantation (HSCT) is currently the only curative strategy for both conditions, massive splenomegaly frequently observed in patients with myelofibrosis is considered to be a risk factor for graft failure or engraftment delay after transplantation. | 23117264 |
| Myelofibrosis Transformation in Essential Thrombocythemia, Primary Myelofibrosis | Stem Cell Exhaustion | The first patient was a 60-year-old woman who received peripheral blood stem cell transplantation for post-essential thrombocythemia myelofibrosis from an HLA-identical sibling; the second patient was a 60-year-old man who received unrelated bone marrow transplantation for primary myelofibrosis. | 23117264 |
| Ischemic cardiomyopathy | Stem Cell Exhaustion | Comparison of allogeneic vs autologous bone marrow-derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial. | 23117550 |
| Ischemic cardiomyopathy, between breakfast and lunch | Stem Cell Exhaustion | Mesenchymal stem cells (MSCs) are under evaluation as a therapy for ischemic cardiomyopathy (ICM). | 23117550 |
| Multiple Myeloma | Stem Cell Exhaustion | There are no uniform guidelines for the treatment of relapsed refractory multiple myeloma (MM), however autologous stem cell transplant (SCT) remains an important treatment modality. | 23121086 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | The use of interferon-a and allogeneic stem cell transplant and more recently of tyrosine kinase inhibitors (TKIs) have improved the outcome of patients with chronic myeloid leukemia (CML). | 23121646 |
| Hepatic Encephalopathy, Acute lymphocytic leukemia | Stem Cell Exhaustion | Posterior reversible encephalopathy syndrome was most often observed during acute lymphoblastic leukemia induction chemotherapy (n = 9, 47.4%) and after hematopoietic stem cell transplantation (n = 8, 42.1%). | 23127265 |
| Encephalopathy, CTCAE 5.0, Hypertension, CTCAE | Stem Cell Exhaustion | Among eight patients with the complication of posterior reversible encephalopathy syndrome after hematopoietic stem cell transplantation, five (62.5%) had a history of hypertension. | 23127265 |
| Hepatic Encephalopathy, Hypertension, CTCAE | Stem Cell Exhaustion | In contrast, among 11 patients with the complication of posterior reversible encephalopathy syndrome without hematopoietic stem cell transplantation, only one (9.1%) had a history of hypertension. | 23127265 |
| Acute lymphocytic leukemia, Hepatic Encephalopathy, Hypertension, CTCAE | Stem Cell Exhaustion | Acute lymphoblastic leukemia chemotherapy regimens apparently comprised the main predisposing factors for posterior reversible encephalopathy syndrome complicated during induction chemotherapy, compared with hypertension and immunosuppressive agents after hematopoietic stem cell transplantation. | 23127265 |
| Fibrosis Assessment | Stem Cell Exhaustion | Confocal imaging of the limbus revealed normal palisades of Vogt structure and epithelial transition in the healthy eyes while demonstrating a variable degree of alterations, including loss of the limbal palisades and of the normal epithelial mosaic, cystic epithelial changes, and subepithelial fibrosis, in the eyes affected by partial or total limbal stem cell deficiency. | 23127748 |
| Hodgkin Disease | Stem Cell Exhaustion | Autologous stem cell transplantation for refractory or poor-risk relapsed Hodgkin's lymphoma: effect of the specific high-dose chemotherapy regimen on outcome. | 23128322 |
| Neoplasms | Stem Cell Exhaustion | Id4 plays an important role in neuronal stem cell differentiation, and its deregulation has been implicated in glial neoplasia. | 23132729 |
| Depression, CTCAE, Anxiety Disorders | Stem Cell Exhaustion | Predictors of anxiety and depression in hematopoietic stem cell transplant patients during protective isolation. | 23132747 |
| Depression, CTCAE, Anxiety Disorders | Stem Cell Exhaustion | To examine in a sample of hematopoietic stem cell transplant patients assessed throughout protective isolation (i) levels of anxiety and depression and (ii) pre-isolation factors (socio-demographics, biomedical variables and personality traits), which might predict higher levels of anxiety and depression during isolation. | 23132747 |
| Depression, CTCAE, Anxiety Disorders | Stem Cell Exhaustion | Anxiety and depression represent a relevant problem for hematopoietic stem cell transplant patients during isolation. | 23132747 |
| Liver carcinoma | Stem Cell Exhaustion | High mobility group AT-hook 2 was also expressed in a subset of hepatocellular carcinomas in association with b-catenin expression; this might represent a subtype of hepatocellular carcinoma with hepatic progenitor cell differentiation. | 23134771 |
| Liver neoplasms | Stem Cell Exhaustion | Expression of high mobility group AT-hook 2, an architectural nuclear factor and marker for hepatic progenitor cells, has not been studied in detail in hepatocellular neoplasms. | 23134771 |
| Intrahepatic bile duct, Bile Ducts, Extrahepatic | Stem Cell Exhaustion | Embryologically, intrahepatic small bile ducts arise from hepatic progenitor cells via ductal plates, whereas the pancreato-extrahepatic biliary progenitor cells expressing the transcription factors PDX1 and HES1 are reportedly involved in the development of the extrahepatic biliary tract and ventral pancreas. | 23134772 |
| Aplastic Anemia | Stem Cell Exhaustion | [Outcome of allogeneic hematopoietic stem cell transplantation from HLA-matched sibling donor for 41 cases of severe aplastic anemia]. | 23134851 |
| Aplastic Anemia | Stem Cell Exhaustion | To evaluate the outcome of allogeneic hematopoietic stem cell transplantation (allo-HSCT) from HLA-matched sibling donor (MSD allo-HSCT) for severe aplastic anemia (SAA). | 23134851 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | 3/80 patients with AML got stem cell mobilization failure. | 23134856 |
| Failure | Stem Cell Exhaustion | 5 of 6 patients who failed to mobilize before got successful stem cell mobilization, 1/6 patient with AML-M(5) got a second failure after the mobilization of VP16 whose first time's mobilization using Ara-C did not succeed. | 23134856 |
| Hematologic Neoplasms | Stem Cell Exhaustion | [Clinical study on high-dose etoposide with granulocyte colony-stimulating factor for mobilization of autologous peripheral blood stem cells in patients with hematologic malignancies]. | 23134856 |
| Hematologic Neoplasms | Stem Cell Exhaustion | To explore the effectivity and safety of single high-dose (HD) etoposide (Vp16) with granulocyte colony-stimulating factor (G-CSF) for mobilization of autologous peripheral blood stem cells (PBSC) in patients with hematologic malignancies. | 23134856 |
| Antilymphocyte Serum | Stem Cell Exhaustion | Autologous bone marrow-derived stem cell therapy is safe and feasible in patients of ALS. | 23135021 |
| Amyotrophic Lateral Sclerosis | Stem Cell Exhaustion | Autologous bone marrow-derived stem cells in amyotrophic lateral sclerosis: a pilot study. | 23135021 |
| Antilymphocyte Serum | Stem Cell Exhaustion | To assess the feasibility, efficacy and safety of autologous bone marrow-derived stem cells in patients of ALS. | 23135021 |
| Antilymphocyte Serum | Stem Cell Exhaustion | We conducted an open-label pilot study of autologous bone marrow-derived stem cells in patients with ALS attending the Neurology Clinic of a tertiary care referral centre. | 23135021 |
| Antilymphocyte Serum | Stem Cell Exhaustion | Ten patients with ALS with mean revised ALS Functional Rating Scale (ALSFRS-R) score of 30.2 (+- 10.58) at baseline received intrathecal autologous bone marrow-derived stem cells. | 23135021 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Prognostic significance of 11q23 aberrations in adult acute myeloid leukemia and the role of allogeneic stem cell transplantation. | 23135353 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Using intention-to treat analysis based on donor availability, we also noted that allogeneic stem cell transplant in first remission had a significant benefit toward improving OS (P<0.001) and relapse-free survival (P<0.001) in patients with AML and 11q23 abnormalities. | 23135353 |
| Multiple Myeloma | Stem Cell Exhaustion | We conducted a phase II trial that evaluated the tolerability and efficacy of combining lenalidomide with melphalan in previously untreated patients with multiple myeloma who were not candidates for autologous stem cell transplantation. | 23141150 |
| Multiple Myeloma | Stem Cell Exhaustion | Interferon (INF)-a was the maintenance treatment of choice after autologous stem cell transplantation in multiple myeloma in the past, but currently Thalidomide is commonly used. | 23142220 |
| Multiple Myeloma | Stem Cell Exhaustion | Bortezomib plus dexamethasone followed by escalating donor lymphocyte infusions for patients with multiple myeloma relapsing or progressing after allogeneic stem cell transplantation. | 23142330 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Isolation of glioma cancer stem cells in relation to histological grades in glioma specimens. | 23143002 |
| Adult Glioblastoma, Specialty Type - cancer | Stem Cell Exhaustion | The existence of cancer stem cells (CSCs) in glioblastoma has been proposed. | 23143002 |
| Communicable Diseases, Lymphoproliferative Disorders, Opportunistic Infections, Kidney Failure, Acute, Specialty Type - cancer, Acute leukemia | Stem Cell Exhaustion | Opportunistic infections were associated with steroids, lymphoproliferative disorders and haematopoietic stem-cell transplantation, whereas noninfectious disorders were associated with acute leukaemia The selected criteria are strongly associated with causes of ARF in cancer patients and could be used to develop an algorithm for selecting first-line diagnostic investigations and empirical treatments. | 23143549 |
| Aggressive Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Diffuse large B-cell lymphoma is an aggressive non-Hodgkin's lymphoma without a standard therapy for patients who relapse after or are not eligible for salvage autologous stem cell transplantation. | 23144193 |
| Central Nervous System, Lymphoma | Stem Cell Exhaustion | Central nervous system recurrence of systemic lymphoma in the era of stem cell transplantation--an International Primary Central Nervous System Lymphoma Study Group project. | 23144196 |
| Lymphoma, Non-Hodgkin | Stem Cell Exhaustion | Autologous stem cell transplantation has greatly improved the prognosis of systemic recurrent non-Hodgkin's lymphoma. | 23144196 |
| Lymphoma | Stem Cell Exhaustion | We, therefore, we performed an international multicenter retrospective study of patients with a central nervous system recurrence of systemic lymphoma to assess the outcome of these patients in the era of stem cell transplantation. | 23144196 |
| Lymphoma | Stem Cell Exhaustion | In conclusion, despite the availability of autologous stem cell transplantation for patients with central nervous system progression or relapse of systemic lymphoma, prognosis is still poor. | 23144196 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Defining the role of high-dose therapy with autologous stem cell rescue in the therapeutic algorithm of follicular lymphoma remains a major challenge. | 23144201 |
| Lymphoma, Follicular | Stem Cell Exhaustion | From 1997 to 2008 80 patients (41 males, 39 females; median age, 51 years; range, 31-67) received high-dose therapy with autologous stem cell rescue with BEAM for relapsed follicular lymphoma at our center. | 23144201 |
| Lymphoma, Follicular | Stem Cell Exhaustion | In conclusion, high-dose therapy with autologous stem cell rescue with BEAM appears to be equally effective in second or third remission of follicular lymphoma. | 23144201 |
| Bisphosphonate-Associated Osteonecrosis of the Jaw, Multiple Myeloma | Stem Cell Exhaustion | Incidence and risk factors of bisphosphonate-related osteonecrosis of the jaw in multiple myeloma patients having undergone autologous stem cell transplantation. | 23147542 |
| Multiple Myeloma | Stem Cell Exhaustion | The purpose of the present study was to evaluate the incidence and risk factors for BRONJ in multiple myeloma patients after high-dose chemotherapy and autologous stem cell transplantation (ASCT). | 23147542 |
| Respiratory Syncytial Virus Infections, Respiratory Tract Infections | Stem Cell Exhaustion | However, it did not prevent lower respiratory tract infections and did not affect the survival rate of allogeneic stem cell transplant recipients who had RSV infection. | 23147965 |
| Myelitis | Stem Cell Exhaustion | The case report that is the subject of this Commentary describes a 27-year-old woman, who, 3 months after a devastating low cervical myelitis, underwent intrathecal mesenchymal stem cell (MSC) infusions. | 23149272 |
| Multiple Myeloma | Stem Cell Exhaustion | We analysed the long-term outcomes of 60 multiple myeloma patients who underwent reduced intensity allogeneic stem cell transplantation between August 2000 and March 2008. | 23151215 |
| Prediabetes syndrome | Stem Cell Exhaustion | Impact of ADMA, endothelial progenitor cells and traditional cardiovascular risk factors on pulse wave velocity among prediabetic individuals. | 23153108 |
| Arterial Stiffness | Stem Cell Exhaustion | Decreased circulating endothelial progenitor cells (EPCs), increased asymmetric dimethyl-arginine (ADMA) levels, traditional cardiovascular risk factors and insulin resistance have all been associated with increased arterial stiffness. | 23153108 |
| Colorectal Carcinoma | Stem Cell Exhaustion | Lgr5 is a potential marker of colorectal carcinoma stem cells that correlates with patient survival. | 23153436 |
| Colorectal Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | In order to determine whether Lgr5 is a potential marker of cancer stem cells, we investigated whether Lgr5 expression correlated with Ki-67 expression and prognosis in colorectal carcinoma. | 23153436 |
| Colorectal Carcinoma | Stem Cell Exhaustion | It may also be considered as a potential marker for colorectal cancer stem cells (CSCs). | 23153436 |
| Encephalitis, Optic Neuritis, Encephalomyelitis, Acute Disseminated | Stem Cell Exhaustion | We report a 27-year-old woman with an episode of encephalitis and optic neuritis, followed by autologous bone marrow mesenchymal stem cell transplants and possible induction of acute disseminated encephalomyelitis-like demyelinating illness. | 23157845 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | Hyper-CVAD chemotherapy or autologous stem cell transplantation in patients with peripheral T cell lymphomas: a single centre report. | 23158157 |
| Multiple Myeloma | Stem Cell Exhaustion | WT1-specific T-cell responses in high-risk multiple myeloma patients undergoing allogeneic T cell-depleted hematopoietic stem cell transplantation and donor lymphocyte infusions. | 23160468 |
| Myeloid Leukemia, Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | While the emergence of WT1-specific cytotoxic T lymphocytes (WT1-CTL) has been correlated with better relapse-free survival after allogeneic stem cell transplantation in patients with myeloid leukemias, little is known about the role of these cells in multiple myeloma (MM). | 23160468 |
| Malignant Neoplasms | Stem Cell Exhaustion | As tissue stem cells exist in many adult tissues other than the CNS, Musashi is considered to be associated with many malignancies. | 23164718 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Haploidentical hematopoietic stem cell transplantation for hematologic malignancies. | 23165479 |
| Lymphoma | Stem Cell Exhaustion | The effectiveness of stem cell mobilization with G-CSF in lymphoma patients is suboptimal. | 23165501 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | Here, we examined the efficacy and safety of a dose-intensified CHOP regimen (Double-CHOP), which was followed by autologous stem-cell transplantation (ASCT) or high-dose methotrexate (HDMTX), in PTCL patients. | 23166041 |
| Hodgkin Disease, LIPC gene | Stem Cell Exhaustion | The management of patients with Hodgkin lymphoma (HL) recurring after stem cell transplantation (SCT) and multiply relapsed disease remains challenging. | 23167437 |
| Aggressive Non-Hodgkin Lymphoma | Stem Cell Exhaustion | High-dose therapy (HDT) followed by transplantation of autologous haemopoietic stem cells is frequently done as part of first-line therapy in young patients with high-risk aggressive B-cell lymphoma. | 23168367 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | Data from 44 MDS subjects receiving subcutaneous romiplostim (dose range 300-1500 mg week(-1) ) were used to develop a pharmacodynamic model consisting of a romiplostim-sensitive progenitor cell compartment linked to the peripheral blood compartment through four transit compartments representing the maturation in the bone marrow from megakaryocytes to platelets. | 23171070 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | High frequency of putative ovarian cancer stem cells with CD44/CK19 coexpression is associated with decreased progression-free intervals in patients with recurrent epithelial ovarian cancer. | 23171677 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | Epithelial ovarian cancer (EOC) cells with CD44 and CK19 coexpression may represent a subset of ovarian cancer stem cells (OCSCs). | 23171677 |
| Injury of kidney | Stem Cell Exhaustion | Acute kidney injury requiring dialysis following carmustine and etoposide during autologous stem cell transplantation. | 23171711 |
| Kidney Failure, Acute, Toxic nephropathy | Stem Cell Exhaustion | While acute renal failure requiring renal replacement therapy is a known but rare complication of autologous stem cell transplantation, acute nephrotoxicity following carmustine and etoposide has not yet been reported. | 23171711 |
| Kidney Failure, Acute | Stem Cell Exhaustion | We present the first case of carmustine-induced acute kidney injury in the setting of autologous stem cell transplantation and perform a review of the literature. | 23171711 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | A placebo-controlled, randomized trial of mesenchymal stem cells in COPD. | 23172272 |
| Inflammation | Stem Cell Exhaustion | As disease pathogenesis includes both chronic pulmonary and systemic inflammation, antiinflammatory effects of systemically administered mesenchymal stem cells (MSCs) may decrease inflammation, resulting in improved lung function and quality of life. | 23172272 |
| Hyponatremia | Stem Cell Exhaustion | Severe hyponatremia is a critical electrolyte abnormality in allogeneic stem cell transplantation (allo-SCT) recipients and >50% of cases of severe hyponatremia are caused by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). | 23173742 |
| Hyperkeratosis, VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | Stem Cell Exhaustion | Dermabrasion can repigment vitiligo through stimulation of melanocyte stem cells and elimination of hyperkeratosis. | 23174056 |
| Colorectal Carcinoma | Stem Cell Exhaustion | The CD133 antigen has been identified as a putative stem cell marker in colorectal cancer tissues. | 23174722 |
| Gastrointestinal Stromal Tumors, Mesenchymal Cell Neoplasm | Stem Cell Exhaustion | Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors originating from interstitial cells of Cajal or related stem cell-like precursors present in the wall of the gastrointestinal tract. | 23174729 |
| Liver carcinoma, Hollings Cancer Center, Specialty Type - cancer | Stem Cell Exhaustion | Recent evidence suggests that hepatocellular carcinoma (HCC) is organized by a subset of cells with stem cell features (cancer stem cells; CSCs). | 23174907 |
| Specialty Type - cancer | Stem Cell Exhaustion | CSCs are considered a pivotal target for the eradication of cancer, and liver CSCs have been identified by the use of various stem cell markers. | 23174907 |
| Liver carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Discrete nature of EpCAM+ and CD90+ cancer stem cells in human hepatocellular carcinoma. | 23174907 |
| Thymic Lymphoepithelioma-Like Carcinoma | Stem Cell Exhaustion | Intrathyroidal epithelial thymoma/carcinoma showing thymus-like differentiation; comparison with thymic lymphoepithelioma-like carcinoma and a possibility of development from a multipotential stem cell. | 23176314 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | In spite of recent advances in molecular diagnostic techniques and expanded indications for allogeneic hematopoietic stem cell transplantation, treatment of acute myeloid leukemia (AML) remains a major challenge. | 23176617 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Many patients with multiple myeloma (MM) are elderly (aged >65 years) or unfit, and therefore ineligible for stem-cell transplantation. | 23176720 |
| Glioblastoma Multiforme Pathway, Neoplasms | Stem Cell Exhaustion | Here, we examined the expression profile of TRIM11, along with two stem cell markers CD133 and nestin, in multiple glioma patient specimens, glioma primary cultures derived from tumors taken at surgery and normal neural stem/progenitor cells (NSCs). | 23178488 |
| Lymphoma, Non-Hodgkin, Familial, Hodgkin Disease, Multiple Myeloma | Stem Cell Exhaustion | Plerixafor and G-CSF for autologous stem cell mobilization in patients with NHL, Hodgkin's lymphoma and multiple myeloma: results from the expanded access program. | 23178544 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Refractory acute graft-versus-host disease (aGVHD) remains an important cause of mortality after allogeneic stem cell transplantation. | 23178634 |
| Malignant tumor of colon | Stem Cell Exhaustion | Properties of monocytes generated from haematopoietic CD34(+) stem cells from bone marrow of colon cancer patients. | 23180014 |
| Bone Marrow, Malignant tumor of colon | Stem Cell Exhaustion | This study explored whether monocytes can be obtained from bone marrow haematopoietic CD34(+) stem cells of colon cancer patients, using previously described protocol of expansion and differentiation to monocytes of cord blood-derived CD34(+) haematopoietic progenitors. | 23180014 |
| Specialty Type - cancer | Stem Cell Exhaustion | These observations indicate that generation of monocytes from CD34(+) stem cells of cancer patients is feasible. | 23180014 |
| Reduced Number, Aortic Aneurysm, Abdominal | Stem Cell Exhaustion | Reduced number and impaired function of circulating endothelial progenitor cells in patients with abdominal aortic aneurysm. | 23182004 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | Circulating endothelial progenitor cells (EPCs) are associated with coronary artery disease (CAD) and predict its outcome. | 23182004 |
| Cerebrovascular accident | Stem Cell Exhaustion | Stem cell therapy: a clinical trial of stroke. | 23183251 |
| Cerebrovascular accident | Stem Cell Exhaustion | Stem cells act as "scaffolds" for neural transplantation and may aid in repair mechanisms in stroke. | 23183251 |
| Diabetes | Stem Cell Exhaustion | Stem cell compartmentalization in diabetes and high cardiovascular risk reveals the role of DPP-4 in diabetic stem cell mobilopathy. | 23184393 |
| Ischemia, diabetic | Stem Cell Exhaustion | Indeed, DPP-4 deficiency restored ischemia (but not G-CSF)-induced stem cell mobilization and improved vascular recovery in diabetic animals. | 23184393 |
| Diabetes | Stem Cell Exhaustion | In conclusion, the analysis of stem cell compartmentalization in humans led us to discover mechanisms of BM unresponsiveness in diabetes determined by tissue-specific DPP-4 dysregulation. | 23184393 |
| Diabetes, Ischemia | Stem Cell Exhaustion | Diabetes differentially affected DPP-4 activity in PB and BM and impaired stem/progenitor cell mobilization after ischemia or G-CSF administration. | 23184393 |
| Multiple Myeloma | Stem Cell Exhaustion | Autologous stem cell transplantation: an effective salvage therapy in multiple myeloma. | 23186983 |
| Allogeneic Hematopoietic Stem Cell Transplantation, Dry Eye Syndromes | Stem Cell Exhaustion | Prevalence of dry eye syndrome after allogeneic hematopoietic stem cell transplantation. | 23187163 |
| Special Handling Code - Dry | Stem Cell Exhaustion | To evaluate the prevalence, severity, and effect of dry eye in patients after allogeneic hematopoietic stem cell transplantation (aHSCT) and to correlate the findings to the duration after transplantation. | 23187163 |
| Prostate carcinoma, Neoplasms | Stem Cell Exhaustion | Gefitinib inhibits the cross-talk between mesenchymal stem cells and prostate cancer cells leading to tumor cell proliferation and inhibition of docetaxel activity. | 23192362 |
| Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Increasing evidence suggests that bone marrow derived mesenchymal stem cells (BM-MSCs) are recruited into the stroma of developing tumors where they contribute to progression by enhancing tumor growth and metastasis, or by inducing anticancer-drug resistance. | 23192362 |
| Prostate carcinoma | Stem Cell Exhaustion | Prostate cancer cells secrete ligands of epidermal growth factor receptor (EGFR) and EGFR signaling could play an important role in the cross-talk between mesenchymal stem cells and prostate cancer cells. | 23192362 |
| Specialty Type - cancer, Carcinoma | Stem Cell Exhaustion | High expression of cancer stem cell markers in cholangiolocellular carcinoma. | 23192764 |
| Specialty Type - cancer | Stem Cell Exhaustion | It is thought to originate from the ductules and/or canals of Hering, where hepatic stem cells (HpSC) are located, but there are few reports on cancer stem cell markers in CLC. | 23192764 |
| Specialty Type - cancer | Stem Cell Exhaustion | Thus, we evaluated the significance of cancer stem cell markers, including CD133, CD44, and EpCAM, in CLC. | 23192764 |
| Hodgkin Disease, galiximab, Specialty Type - cancer, leukemia | Stem Cell Exhaustion | Cancer and Leukemia Group B (CALGB) 50602 (Alliance) tested single-agent galiximab in a highly refractory group of patients with Hodgkin lymphoma (median 3 prior regimens, 83% failing after prior stem cell transplant) to determine the efficacy. | 23194022 |
| Multiple Myeloma | Stem Cell Exhaustion | Early versus delayed autologous stem cell transplant in patients receiving novel therapies for multiple myeloma. | 23194056 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Autologous stem cell transplant (ASCT) is an effective treatment for multiple myeloma (MM). | 23194056 |
| Bronchiolitis Obliterans | Stem Cell Exhaustion | Airway dilation in bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. | 23195332 |
| Bronchiolitis Obliterans, Pulmonary Complication, Bosnian language | Stem Cell Exhaustion | Bronchiolitis obliterans syndrome (BOS) is a late, non-infectious pulmonary complication following hematopoietic stem cell transplantation (HSCT). | 23195332 |
| Diabetes | Stem Cell Exhaustion | Transgene-free disease-specific induced pluripotent stem cells from patients with type 1 and type 2 diabetes. | 23197849 |
| Neurologic Deficits | Stem Cell Exhaustion | Targeting p38 mitogen-activated protein kinase signaling restores subventricular zone neural stem cells and corrects neuromotor deficits in Atm knockout mouse. | 23197859 |
| Ischemia | Stem Cell Exhaustion | A phase II trial of autologous transplantation of bone marrow stem cells for critical limb ischemia: results of the Naples and Pietra Ligure Evaluation of Stem Cells study. | 23197862 |
| Specialty Type - cancer | Stem Cell Exhaustion | The concept of a stem cell subpopulation as understood from normal epithelial tissue or bone marrow function has been extended to our understanding of cancer tissue and is now the target of treatment efforts specifically directed to this subpopulation. | 23201460 |
| Adult Glioblastoma, Neoplasms, Malignant Neoplasms | Stem Cell Exhaustion | In glioblastoma, as well as in other cancers, increased expression of aldehyde dehydrogenase (ALDH) has been found localized within a minority sub-population of tumor cells which demonstrate stem cell properties. | 23201460 |
| Heat shock proteins | Stem Cell Exhaustion | A separate body of research associated increased expression of heat-shock protein-90 (HSP90) with stem cell attributes. | 23201460 |
| Adult Glioblastoma | Stem Cell Exhaustion | That two previously identified proteins associated with stem cell attributes tend to be co-expressed in the same individual glioblastoma cells might have clinical utility. | 23201460 |
| Adult Glioblastoma | Stem Cell Exhaustion | These should be explored for the potential to retard aspects of glioblastoma stem cells' function subserved by ALDH and HSP90. | 23201460 |
| Blastic plasmacytoid dendritic cell neoplasm | Stem Cell Exhaustion | Stem cell transplantation can provide durable disease control in blastic plasmacytoid dendritic cell neoplasm: a retrospective study from the European Group for Blood and Marrow Transplantation. | 23203822 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Due to the high-risk profile of his AML, allogeneic stem cell transplantation (SCT) was performed. | 23207728 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | To better determine whether the presence of 6 or fewer apoptotic bodies is sufficient for the diagnosis of GVHD, we retrospectively reviewed 78 colon biopsies from 66 patients who received either hematopoietic stem cell (HSCT) or cord blood cell transplantation and whose colon biopsies exhibited apoptotic bodies. | 23211294 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Comparison of human adipose-derived stem cells and bone marrow-derived stem cells in a myocardial infarction model. | 23211469 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Treatment of myocardial infarction (MI) with bone marrow-derived mesenchymal stem cells and recently also adipose-derived stem cells has shown promising results. | 23211469 |
| Osteopenia | Stem Cell Exhaustion | Transplantation of human umbilical cord blood-derived mesenchymal stem cells or their conditioned medium prevents bone loss in ovariectomized nude mice. | 23215868 |
| Liver carcinoma | Stem Cell Exhaustion | Impact of stem cell marker expression on recurrence of TACE-treated hepatocellular carcinoma post liver transplantation. | 23216644 |
| Liver carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | The existence of a progenitor cell population, sometimes called cancer stem cells (CSCs), has been proposed to be one mechanism accounting for the chemotherapy resistance and recurrence of hepatocellular carcinoma. | 23216644 |
| Myocardial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Myocardial dysfunction in patients with type 2 diabetes mellitus: role of endothelial progenitor cells and oxidative stress. | 23217199 |
| Cockayne Syndrome | Stem Cell Exhaustion | Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria. | 23217256 |
| Progeria | Stem Cell Exhaustion | The link between conserved SIRT1 longevity pathway and progeria suggests a stem cell-based and SIRT1 pathway-dependent therapeutic strategy for progeria. | 23217256 |
| Venous Thrombosis, Hemolysis (biological function), Bone marrow hypocellularity, Hemoglobinuria, CTCAE 3.0 | Stem Cell Exhaustion | Paroxysmal nocturnal hemoglobinuria is a clonal stem cell disorder typically characterized by hemolysis, bone marrow failure, and venous thrombosis. | 23217954 |
| MS gene | Stem Cell Exhaustion | Recently autologous haematopoietic stem cell transplantation (AHSCT) has been introduced for the treatment of severe forms of multiple sclerosis (MS). | 23218837 |
| MS gene | Stem Cell Exhaustion | Immunohistochemistry analysis of bone marrow biopsies in multiple sclerosis patients undergoing autologous haematopoietic stem cells transplantation. | 23218837 |
| Sarcoma, Myeloid | Stem Cell Exhaustion | While prospective evaluations are needed, chemotherapy with allogenic hematopoietic stem cell transplantation should be considered as the optimal therapy for isolated myeloid sarcoma. | 23218987 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The mechanisms by which hematopoietic stem and progenitor cells (HSC and HPC) from myelodysplastic syndromes (MDS) undergo ineffective production of blood cells and disease transformation into acute myeloid leukemia remain to be investigated. | 23219618 |
| Specialty Type - cancer, Nasopharyngeal carcinoma | Stem Cell Exhaustion | Aldehyde dehydrogenase 1, a functional marker for identifying cancer stem cells in human nasopharyngeal carcinoma. | 23220285 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Aldehyde dehydrogenase 1 (ALDH1) activity has now been employed successfully as a cancer stem cells (CSCs) marker in various tumors. | 23220285 |
| Aortic Valve Insufficiency | Stem Cell Exhaustion | Circulating progenitor and apoptotic progenitor cells in patients with aortic regurgitation. | 23220773 |
| Neoplasms | Stem Cell Exhaustion | These findings suggested the probable single stem cell origin of the tumor with differentiation to both cell groups rather than a combination of two different tumors. | 23221400 |
| Dyskeratosis Congenita, Post-transplant lymphoproliferative disorder | Stem Cell Exhaustion | Posttransplant lymphoproliferative disorder complicating hematopoietic stem cell transplantation in a patient with dyskeratosis congenita. | 23222806 |
| Aplastic Anemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We present a case of a 28-year-old woman with DC who was admitted for hematopoietic stem cell transplantation (HSCT) for aplastic anemia and who developed acute myeloid leukemia with complex genetic karyotype abnormalities including the MLL (11q23) gene, 1q25, and chromosome 8. | 23222806 |
| MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Azacitidine fails to eradicate leukemic stem/progenitor cell populations in patients with acute myeloid leukemia and myelodysplasia. | 23223186 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Experimentally, leukemic stem/progenitor cells (LSC) propagate disease in animal models of AML and it has been postulated that their relative chemo-resistance contributes to disease relapse. | 23223186 |
| Chronic graft-versus-host disease | Stem Cell Exhaustion | Differing impacts of pretransplant serum ferritin and C-reactive protein levels on the incidence of chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. | 23225486 |
| Tears body substance | Stem Cell Exhaustion | Most cases recovered by using artificial tears, antibiotic ointment and eye wrap, and other patients required corneal limbal stem cell transplantation with conjunctival flap, even keratoplasty. | 23225842 |
| Squamous cell carcinoma of esophagus | Stem Cell Exhaustion | A genetic analysis revealed germ-line lineage-derived chimeric cellular populations of the donor and patient on both the esophageal squamous cell carcinoma and non tumorous portions of the patient's esophageal mucosa with a preponderance of the patient's germ-line lineage-derived cells, suggesting that repopulated donor-derived hemopoietic stem cells in the esophageal epithelia only partially contributed to the carcinogenesis of esophageal squamous cell carcinoma several years after bone marrow transplantation. | 23225908 |
| Acute myocardial infarction, Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Worse clinical outcomes in acute myocardial infarction patients with type 2 diabetes mellitus: relevance to impaired endothelial progenitor cells mobilization. | 23226370 |
| Impaired | Stem Cell Exhaustion | We hypothesized that this may be related to impairment of bone marrow-derived endothelial progenitor cells (EPCs) mobilization. | 23226370 |
| Calcinosis | Stem Cell Exhaustion | This knowledge may help in designing better strategies for stem cell differentiation into chondrocyte-like cells, from this source, with Dic being a viable option for treating OA pain, with an eye toward preventing the potential to enhance calcification in the repair of cartilage and degenerated intervertebral discs. | 23231452 |
| Hypertrophy, Degenerative polyarthritis | Stem Cell Exhaustion | We have previously shown that mesenchymal stem cells (MSCs) from patients with osteoarthritis (OA) constitutively express type X collagen, a marker of late-stage chondrocyte hypertrophy, osteogenic marker genes, including alkaline phosphatase (ALP), bone sialoprotein (BSP), and osteocalcin (OC), and chondrogenesis marker gene aggrecan (ACAN). | 23231452 |
| Degenerative polyarthritis | Stem Cell Exhaustion | The upregulation of COL10A1 in normal MCSs by Acet and Npx may explain why stem cells from patients with OA express COL10A1 constitutively. | 23231452 |
| Respiratory Diaphragm | Stem Cell Exhaustion | The animals injected with stem cells underwent laparoscopy so that stem cells from GFP-labelled rabbit olfactory epithelium could be locally injected into the diaphragm muscle. | 23231953 |
| Multiple Myeloma | Stem Cell Exhaustion | Efficacy of stem cell mobilization in patients with newly diagnosed multiple myeloma after a CTD (cyclophosphamide, thalidomide, and dexamethasone) regimen. | 23233155 |
| Multiple Myeloma | Stem Cell Exhaustion | Have drug combinations supplanted stem cell transplantation in myeloma? | 23233601 |
| Retinal Diseases | Stem Cell Exhaustion | [Effects of bone marrow mesenchymal stem cell transplantation on retinal cell apoptosis in premature rats with retinopathy]. | 23234789 |
| Retinopathy of Prematurity, Infant, Premature, Retinal Diseases | Stem Cell Exhaustion | To explore the effects of marrow mesenchymal stem cell (BMSC) transplantation on retinal cells apoptosis and changes to neurotrophin-3 (NT-3 and ciliary neurotrophic factor (CNTF) in rats with retinopathy of prematurity (ROP). | 23234789 |
| Autoimmune Diseases, MS gene, Glomerulonephritis, Lupus Erythematosus | Stem Cell Exhaustion | Previous in vivo studies have shown that mesenchymal stem cell (MSC) transplantation significantly improves the condition of a number of autoimmune diseases including autoimmune cerebrospinal meningitis, multiple sclerosis, glomerulonephritis and systemic lupus erythematosus. | 23237239 |
| Rheumatoid Arthritis | Stem Cell Exhaustion | To investigate the immunoregulatory effect of stem cell transplantation, human umbilical cord MSCs were co-cultured with peripheral blood mononuclear cells (PBMCs) from patients with rheumatoid arthritis (RA). | 23237239 |
| Rheumatoid Arthritis | Stem Cell Exhaustion | The allogeneic umbilical cord mesenchymal stem cells regulate the function of T helper 17 cells from patients with rheumatoid arthritis in an in vitro co-culture system. | 23237239 |
| Respiratory Tract Infections | Stem Cell Exhaustion | hMPV can cause morbidity in hematopoietic stem cell transplant recipients and recent research has demonstrated that it is an important virus in patients admitted to hospital with respiratory infections and suspected of having pandemic 2009 influenza A (H1N1pdm09) virus. | 23239530 |
| H1N1, Influenza | Stem Cell Exhaustion | A total of 288 samples were tested: 165 samples were collected from patients with suspected influenza A (H1N1) pdm09 infection during the first pandemic wave in 2009; and 123 samples were collected from patients of a hematopoietic stem cell transplantation program in 2008-2009. | 23239530 |
| Influenza due to Influenza A virus subtype H1N1 | Stem Cell Exhaustion | hMPV was detected in 14.2% (41/288) of all samples: 17% (28/165) of immunocompetent patients with suspected H1N1 infection and 10.6% (13/123) among hematopoietic stem cell transplant recipients. | 23239530 |
| Inflammation, Stem Cell Factor | Stem Cell Exhaustion | RDW, markers of inflammation and stem cell factor (SCF) were determined. | 23239558 |
| Specialty Type - cancer | Stem Cell Exhaustion | This positive feedback loop regulating BMI1 expression may be relevant to the role of BMI1 in promoting cancer and maintaining stem cell phenotype. | 23239878 |
| Specialty Type - cancer | Stem Cell Exhaustion | It is often overexpressed in cancer cells and is required for self-renewal of stem cells. | 23239878 |
| Fibrosis Assessment, Injury of liver | Stem Cell Exhaustion | During liver injury, their close proximity to hepatic progenitor cells and the ductular reaction may enable them to regulate liver repair and fibrosis. | 23240894 |
| Malignant Neoplasms | Stem Cell Exhaustion | Evaluation of 2009 pandemic H1N1 influenza vaccination in adults with lymphoid malignancies receiving chemotherapy or following autologous stem cell transplant. | 23240909 |
| Malignant Neoplasms | Stem Cell Exhaustion | Adults with a lymphoid malignancy receiving active systemic therapy, or within a year after autologous stem cell transplant, received one dose of AS03-adjuvanted A/California/7/2009 (H1N1) vaccine, and were randomized 21 days later to a second dose or no further vaccination. | 23240909 |
| Palmar-plantar erythrodysesthesia syndrome | Stem Cell Exhaustion | Using cytotoxic drugs with differential effects on hematopoietic stem cells, our data imply that chemotherapy-induced telomere shortening results from direct damage to hematopoietic stem cells and/or the induction of proliferative stress on bone marrow while sparing repopulating stem cells. | 23240911 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Myelodysplastic syndrome (MDS) is a clonal disorder arising from an alteration in multipotent stem cells, which lose the ability of normal proliferation and differentiation. | 23240925 |
| Dyskeratosis Congenita, Leukoencephalopathy | Stem Cell Exhaustion | Irreversible leukoencephalopathy after reduced-intensity stem cell transplantation in a dyskeratosis congenita patient with TINF2 mutation. | 23242325 |
| Dyskeratosis Congenita | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (HSCT) for dyskeratosis congenita (DC) is challenging due to severe treatment-related adverse effects. | 23242325 |
| Aggressive Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Phase II study of central nervous system (CNS)-directed chemotherapy including high-dose chemotherapy with autologous stem cell transplantation for CNS relapse of aggressive lymphomas. | 23242601 |
| Carotid Stenosis | Stem Cell Exhaustion | To investigate the relationship between the changes in the number and function of the late endothelial progenitor cells (EPC) in peripheral blood and the carotid artery stenosis. | 23242972 |
| Adult Glioblastoma | Stem Cell Exhaustion | The CD133 antigen is a marker of radio- and chemo-resistant stem cell populations in glioblastoma (GBM). | 23245659 |
| Tears body substance | Stem Cell Exhaustion | Surgical repairs of tears in the vascular region of the meniscus usually heal better than repairs performed in the avascular region; thus, we hypothesized that this region might possess a richer supply of vascular-derived stem cells than the avascular region. | 23247715 |
| LIPC gene | Stem Cell Exhaustion | Patients with relapsed and refractory HL who were ineligible for autologous stem-cell transplantation (ASCT), or for whom this treatment failed, received bendamustine 120 mg/m(2) as a 30-minute infusion on days 1 and 2 every 28 days with growth factor support. | 23248254 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Study of the quantitative, functional, cytogenetic, and immunoregulatory properties of bone marrow mesenchymal stem cells in patients with B-cell chronic lymphocytic leukemia. | 23249221 |
| Type II Mucolipidosis, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Acute myeloid leukemia (AML) is a life-threatening stem cell disease characterized by uncontrolled proliferation and accumulation of myeloblasts. | 23249862 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Together, the BRD4-targeting drug JQ1 exerts major anti-leukemic effects in a broad range of human AML subtypes, including relapsed and refractory patients and all relevant stem- and progenitor cell compartments, including CD34+/CD38- and CD34+/CD38+ AML cells. | 23249862 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia AML. | 23249862 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | BRD4 was found to be expressed at the mRNA and protein level in unfractionated AML cells as well as in highly enriched CD34+/CD38- and CD34+/CD38+ stem- and progenitor cells in all patients examined. | 23249862 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | The introduction of tyrosine kinase inhibitors (TKIs) for chronic myeloid leukemia (CML) led to a dramatic change in the role of allogeneic stem cell transplantation (SCT) with a rapid decline in the number of patients receiving SCT in first chronic phase (CP1). | 23250623 |
| diabetic | Stem Cell Exhaustion | Global remodeling of the vascular stem cell niche in bone marrow of diabetic patients: implication of the microRNA-155/FOXO3a signaling pathway. | 23250986 |
| Primary adenocarcinoma of lung, Specialty Type - cancer | Stem Cell Exhaustion | Expression of the potential cancer stem cell markers, CD133, CD44, ALDH1, and b-catenin, in primary lung adenocarcinoma--their prognostic significance. | 23252868 |
| Spinal Muscular Atrophy | Stem Cell Exhaustion | Genetic correction of human induced pluripotent stem cells from patients with spinal muscular atrophy. | 23253609 |
| Small Nuclear Ribonucleoprotein Polypeptide F | Stem Cell Exhaustion | Induced pluripotent stem cells (iPSCs) generated from skin fibroblasts from SMA patients and genetically corrected have been proposed to be useful for autologous cell therapy. | 23253609 |
| Multiple Myeloma | Stem Cell Exhaustion | Sequential treatment with bortezomib plus dexamethasone followed by autologous hematopoietic stem cell transplantation in patients with multiple myeloma. | 23253719 |
| Multiple Myeloma | Stem Cell Exhaustion | Whether the sequential treatment with bortezomib plus dexamethasone (BD) followed by autologous hematopoietic stem cell transplantation (ASCT) could extend the overall survival period in multiple myeloma patients is still not clear. | 23253719 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | One possible explanation is that cancer stem cells (CSCs) elude drug treatment, emerge and reproduce a tumor. | 23254289 |
| Glioblastoma Multiforme Pathway, Neoplasms | Stem Cell Exhaustion | Literature data indicate that glioma stem cells may give rise to both tumor cells and endothelial progenitor cells (EPCs). | 23254765 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | The presence of genetic aberrations of glioma cells in intratumoral EPCs may point to transdifferentiation of glioma stem cells into EPCs. | 23254765 |
| Neoplasms | Stem Cell Exhaustion | Intratumoral, not circulating, endothelial progenitor cells share genetic aberrations with glial tumor cells. | 23254765 |
| Adult Glioblastoma, Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Cancer stem cell theory postulates that a small population of tumor-initiating cells is responsible for the development, progression and recurrence of several malignancies, including glioblastoma. | 23255107 |
| Adult Glioblastoma, Specialty Type - cancer | Stem Cell Exhaustion | Interestingly, analyzing by FACS the antiproliferative effects of metformin on CD133-expressing subpopulation, a component of glioblastoma cancer stem cells, a higher reduction of proliferation was observed as compared with CD133-negative cells, suggesting a certain degree of cancer stem cell selectivity in its effects. | 23255107 |
| Specialty Type - cancer, Childhood Breast Carcinoma, Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Metformin, a first-line drug for type II diabetes, was reported to possess anticancer properties affecting the survival of cancer stem cells in breast cancer models. | 23255107 |
| Adult Glioblastoma | Stem Cell Exhaustion | The specificity of metformin antiproliferative effects toward glioblastoma tumor-initiating cells was confirmed by the lack of significant inhibition of normal human stem cells (umbilical cord-derived mesenchymal stem cells) in vitro proliferation after metformin exposure. | 23255107 |
| Liver carcinoma, Disease, Metabolic Diseases, Specialty Type - cancer | Stem Cell Exhaustion | A number of marker genes for many diseases have been found in this chromosome, including genetic diseases (e.g., hepatocellular carcinoma) and biomedical research (cardiac system, aging, metabolic disorders, immune system, cancer and stem cell) related genes (e.g., oncogenes, growth factors). | 23256888 |
| Drusen | Stem Cell Exhaustion | This adult stem cell-based system using chronic TBHP treatment of hRPE represents a novel in vitro model useful for the study of drusen formation and dry AMD pathophysiology. | 23257616 |
| Endocrine System Diseases, Specialty Type - cancer | Stem Cell Exhaustion | The main risk factors for endocrine disease were male sex (hazard ratio (HR)=1.45, 95% confidence interval (95% CI) 1.05-1.99), radiotherapy (HR=1.91, 95% CI 1.28-2.84), hematopoietic stem cells transplantation (HR=3.11, 95% CI 2.23-4.34), and older age at cancer diagnosis (HR=1.89, 95% CI 1.25-2.85). | 23258270 |
| Medulloblastoma | Stem Cell Exhaustion | Reduced-dose craniospinal radiotherapy followed by tandem high-dose chemotherapy and autologous stem cell transplantation in patients with high-risk medulloblastoma. | 23258845 |
| Medulloblastoma | Stem Cell Exhaustion | We assessed the feasibility and effectiveness of reduced-dose craniospinal (CS) radiotherapy (RT) followed by tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/autoSCT) in reducing late adverse effects without jeopardizing survival among children with high-risk medulloblastoma (MB). | 23258845 |
| Adult Glioblastoma, Neoplasms | Stem Cell Exhaustion | On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells. | 23262510 |
| Neoplasms | Stem Cell Exhaustion | GBM-derived brain tumor stem cells (BTSCs) closely model this molecular heterogeneity and likely have a key role in tumor recurrence and therapeutic resistance. | 23262510 |
| Spastic Paraplegia, Hereditary | Stem Cell Exhaustion | A patient-derived stem cell model of hereditary spastic paraplegia with SPAST mutations. | 23264559 |
| Cardiomyopathies | Stem Cell Exhaustion | The Implantation of Autologous CD133(+) Stem Cells in Patients Undergoing CABG (IMPACT-CABG) trial is investigating the feasibility, safety, and efficacy of intramyocardial injections of autologous CD133(+) stem cells during coronary artery bypass grafting (CABG) in patients with chronic ischemic cardiomyopathy. | 23265095 |
| Cardiomyopathies | Stem Cell Exhaustion | This work represents the first Canadian experience with CD133(+) stem cells for the treatment of chronic ischemic cardiomyopathy. | 23265095 |
| Erythrocytosis | Stem Cell Exhaustion | Since erythrocytosis is the only feature that distinguishes PV from ET, we also compared specific miRNA expression in the nucleated erythroid cells directly descended from the early erythroid progenitor cells of PV and ET patients. | 23265742 |
| MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Outcome of donor lymphocyte infusion after T cell-depleted allogeneic hematopoietic stem cell transplantation for acute myelogenous leukemia and myelodysplastic syndromes. | 23266740 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Relapse occurs in 30%-50% of recipients of T cell-depleted (TCD) reduced-intensity conditioned (RIC) hematopoietic stem cell transplantation (HSCT) for acute myelogenous leukemia (AML) and myelodysplastic syndromes (MDS). | 23266740 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Dynamics of circulating endothelial cells and endothelial progenitor cells in breast cancer patients receiving cytotoxic chemotherapy. | 23268621 |
| Multiple Myeloma | Stem Cell Exhaustion | Sleep measured by polysomnography in patients receiving high-dose chemotherapy for multiple myeloma prior to stem cell transplantation. | 23269772 |
| Multiple Myeloma | Stem Cell Exhaustion | To describe the objective sleep of patients receiving chemotherapy for multiple myeloma (MM) prior to stem cell transplantation. | 23269772 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | It may be a good choice for patients with CML who cannot accept a hematopoietic stem cell transplant and imatinib or who fail IFN-a therapy. | 23270584 |
| Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | It has been reported that chronic graft-versus-host disease (cGVHD) is associated with significant morbidity and mortality after allogeneic stem cell transplantation (allo-SCT). | 23270984 |
| Meningoencephalitis | Stem Cell Exhaustion | Detection of donor-derived CMV-specific T cells in cerebrospinal fluid in a case of CMV meningoencephalitis after cord blood stem cell transplantation. | 23271411 |
| Meningoencephalitis | Stem Cell Exhaustion | Cytomegalovirus (CMV) meningoencephalitis is a rather rare complication after allogeneic stem cell transplantation. | 23271411 |
| Neoplasms | Stem Cell Exhaustion | Using the BLT humanized mouse as a stem cell based gene therapy tumor model. | 23271478 |
| Immunocompromised Host | Stem Cell Exhaustion | In this model, 6 to 8 week old NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) immunocompromised mice receive the thy/liv implant as in the SCID-hu mouse model only to be followed by a second human hematopoietic stem cell transplant (4). | 23271478 |
| Febrile Neutropenia, Acute leukemia | Stem Cell Exhaustion | In a double-blind, placebo-controlled, multicenter study, patients with acute leukemia undergoing chemotherapy or allogeneic hematopoietic stem cell transplantation (HSCT) recipients were randomized to broad-spectrum antibacterial therapy plus voriconazole (immediate) or placebo (deferred) after the onset of neutropenic fever. | 23271674 |
| Chemical injury | Stem Cell Exhaustion | Effective progenitor cell recruitment to the ischemic injury zone is a prerequisite for any potential therapeutic effect. | 23271789 |
| Proteinuria, Pneumonitis, CTCAE, Purpura, Thrombotic Thrombocytopenic, Cystitis | Stem Cell Exhaustion | Pneumonitis (n=5) or proteinuria over 1.5 g per day (n=13) were only observed in kidney transplant patients, while polyomavirus-induced cystitis (n=3) and thrombotic thrombocytopenic purpura (n=7) were only observed in stem cell transplanted patients. | 23274324 |
| Fever | Stem Cell Exhaustion | Forty-four febrile neutropaenic patients, following haematopoietic stem cell transplantation (HSCT) and with multi-lumen CVCs in place, were investigated using the DTP method of blood samples drawn from every lumen of the CVC and a peripheral vein. | 23274928 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Prognostic impact of allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia patients with internal tandem duplication of FLT3. | 23276395 |
| FLT3 Internal Tandem Duplication, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The FLT3 gene with internal tandem duplication (ITD) is a poor prognostic factor in patients with acute myeloid leukemia (AML), and the efficacy of allogeneic hematopoietic stem cell transplantation (HSCT) for AML patients with FLT3-ITD is controversial. | 23276395 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Clofarabine does not negatively impact the outcomes of patients with acute myeloid leukemia undergoing allogeneic stem cell transplantation. | 23276886 |
| Toxic liver disease, Venoocclusive disease | Stem Cell Exhaustion | We evaluated whether clofarabine-containing chemotherapy predisposed patients to hepatic toxicity (particularly venoocclusive disease [VOD]) after allogeneic stem cell transplantation (allo-SCT). | 23276886 |
| Hepatotoxicity, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Many patients with AML undergo allogeneic stem cell transplantation (allo-SCT), a procedure that is also associated with hepatotoxicity. | 23276886 |
| B-Cell Lymphomas, Lymphoma | Stem Cell Exhaustion | Prognostic factors for patients with diffuse large B cell lymphoma and transformed indolent lymphoma undergoing autologous stem cell transplantation in the positron emission tomography era. | 23278720 |
| B-Cell Lymphomas, Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | In the positron emission tomography (PET) era, traditional prognostic factors may not apply for patients with relapsed/refractory (R/R) diffuse large B cell lymphoma (DLBCL) undergoing autologous stem cell transplantation (ASCT). | 23278720 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease (GvHD) is a common complication following haematopoietic stem cell transplant but little is published about the impact of this condition on hospital readmission rates. | 23278853 |
| Infection, Microbiological, Amyloidosis | Stem Cell Exhaustion | Microbiologically documented infections in patients undergoing high-dose melphalan and autologous stem cell transplantation for the treatment of light chain amyloidosis. | 23279695 |
| Amyloidosis | Stem Cell Exhaustion | Immunoglobulin light chain (AL) amyloidosis can be treated with high-dose melphalan and autologous stem cell transplantation (HDM/SCT). | 23279695 |
| Disease, Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0 | Stem Cell Exhaustion | Paroxysmal nocturnal hemoglobinuria (PNH) is a unique disorder caused by a PIG-A gene mutation in a stem cell clone. | 23281097 |
| Muscular Dystrophy, Dilated Cardiomyopathy Pathway | Stem Cell Exhaustion | Injection of vessel-derived stem cells prevents dilated cardiomyopathy and promotes angiogenesis and endogenous cardiac stem cell proliferation in mdx/utrn-/- but not aged mdx mouse models for duchenne muscular dystrophy. | 23283493 |
| Doctor of Chiropractic, Myocardium | Stem Cell Exhaustion | In summary, ADMs delay or prevent development of DCM in dystrophin-deficient heart, but timing of stem cell transplantation may be critical for achieving benefit with cell therapy in DMD cardiac muscle. | 23283493 |
| Muscular Dystrophy, Duchenne, Doctor of Chiropractic | Stem Cell Exhaustion | We hypothesized that mesoangioblast stem cells (aorta-derived mesoangioblasts [ADMs]) would restore dystrophin and alleviate or prevent DCM in animal models of DMD. | 23283493 |
| Illness (finding) | Stem Cell Exhaustion | Human rhinovirus C in adult haematopoietic stem cell transplant recipients with respiratory illness. | 23290385 |
| Ischemic stroke | Stem Cell Exhaustion | Ischaemic stroke induces endothelial progenitor cell (EPC) mobilisation from bone marrow into peripheral blood. | 23290569 |
| Hemorrhagic, Ischemic stroke | Stem Cell Exhaustion | Increased circulating endothelial progenitor cells in patients with haemorrhagic and ischaemic stroke: the role of endothelin-1. | 23290569 |
| Ischemia, Corneal Endothelial Cell Loss | Stem Cell Exhaustion | Circulating endothelial progenitor cells (EPCs) are recruited from the blood system to sites of ischemia and endothelial damage, where they contribute to the repair and development of blood vessels. | 23291334 |
| Multiple Myeloma | Stem Cell Exhaustion | Evaluation of the feasibility and efficacy of autologous stem cell transplantation in elderly patients with multiple myeloma. | 23291675 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | The feasibility and efficacy of high-dose melphalan (HD-MEL) followed by autologous hematopoietic stem cell transplantation (auto-SCT) in elderly patients with multiple myeloma (MM) are discussed. | 23291675 |
| Neoplasms, Malignant Neoplasms | Stem Cell Exhaustion | Thus, we propose that stromal cell-mediated delivery of TNFa to human tumors [using transfected fibroblasts or mesenchymal stem cells (hMSCs)] may be a novel and effective strategy for the prevention and treatment of human cancers. | 23292149 |
| Malignant Neoplasms | Stem Cell Exhaustion | Intermediate-dose Ara-C plus G-CSF for stem cell mobilization in patients with lymphoid malignancies, including predicted poor mobilizers. | 23292239 |
| Malignant Neoplasms | Stem Cell Exhaustion | The optimal protocol for mobilization of hematopoietic stem cells in patients with lymphoid malignancies has not been determined so far. | 23292239 |
| Glioblastoma Multiforme Pathway, Glioma, Adult Glioblastoma | Stem Cell Exhaustion | More recently, it has been reported that miR-326 was down-regulated in glioblastoma tissues and might regulate the metabolic activity of glioma and glioma stem cells, suggesting the involvement of miR-326 in tumorigenesis and progression of gliomas. | 23292865 |
| Hodgkin Disease, LIPC gene | Stem Cell Exhaustion | Hodgkin's Lymphoma (HL) is highly chemoresponsive, and majority of patients respond to therapy except for a small number which require high-dose therapy and stem cell rescue for salvage. | 23292874 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We assessed WT1 expression (expressed as messenger copies/10(4) ABL1) from marrow cells of 122 patients with acute myeloid leukaemia (AML), before and after an unmanipulated allogeneic haemopoietic stem cell transplant (HSCT). | 23294252 |
| Diabetes Mellitus | Stem Cell Exhaustion | Diabetes mellitus after allogeneic hematopoietic stem cell transplantation. | 23296512 |
| No endocrine abnormalities, Dominica, Diabetes Mellitus | Stem Cell Exhaustion | Survivors of pediatric hematopoietic stem cell transplantation (HSCT) are known to be at risk of developing endocrine abnormalities, but occurrence of diabetes mellitus (DM) is a relatively recent observation. | 23296512 |
| Hepatic Veno-Occlusive Disease | Stem Cell Exhaustion | Tolvaptan as an alternative treatment for refractory fluid retention associated with sinusoidal obstruction syndrome after allogeneic stem cell transplantation. | 23297121 |
| Precursor T-cell lymphoblastic lymphoma | Stem Cell Exhaustion | A 42-year-old male with primarily refractory T-lymphoblastic lymphoma underwent allogeneic peripheral blood stem cell transplantation from an HLA-matched sibling donor. | 23297121 |
| Post-transplant lymphoproliferative disorder, Primary Myelofibrosis | Stem Cell Exhaustion | Case 2-2012: a 57-year-old woman with post-transplant lymphoproliferative disorder after allogeneic stem cell transplantation for primary myelofibrosis. | 23297524 |
| Failure, Glaucoma, CTCAE | Stem Cell Exhaustion | Most patients will need treatment for glaucoma and some may require treatment for tear-film instability and/or stem cell failure. | 23298884 |
| leukemia | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (HSCT) from a human leukocyte antigen (HLA)-haploidentical family donor (haplo-HSCT) is a readily available and potentially curative option for high-risk leukemia. | 23299798 |
| Myeloproliferative disease | Stem Cell Exhaustion | JAK2 p.V617F allele burden in myeloproliferative neoplasms one month after allogeneic stem cell transplantation significantly predicts outcome and risk of relapse. | 23300178 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | Prognosis of patients with primary central nervous system lymphoma after high-dose chemotherapy followed by autologous stem cell transplantation. | 23300179 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | High-dose chemotherapy followed by autologous stem cell transplantation has been shown to be feasible and highly effective in newly diagnosed primary central nervous system lymphoma. | 23300179 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | We retrospectively analyzed 105 immunocompetent patients with primary central nervous system lymphoma who underwent high-dose chemotherapy followed by autologous stem cell transplantation with or without whole brain radiotherapy as first-line consolidation treated at 12 German centers between 1997 and 2011. | 23300179 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | High-dose chemotherapy followed by autologous stem cell transplantation is a highly effective and safe treatment modality for selected primary central nervous system lymphoma patients. | 23300179 |
| Aortic Aneurysm | Stem Cell Exhaustion | Interestingly Jagged1, NICD, and Hes1 were highly present in CD34+ stem cells and Stro-1+ stem cells in aortas from TAA and TAD patients. | 23300792 |
| Choroid Plexus Carcinoma | Stem Cell Exhaustion | Successful treatment of a recurrent choroid plexus carcinoma with surgery followed by high-dose chemotherapy and stem cell rescue. | 23301664 |
| TP53 gene, "cytidylyl-(3-5)-cytidine | Stem Cell Exhaustion | The authors report long-term survival of a 1-year-old patient with recurrent CPC and Li-Fraumeni syndrome with surgical resection and high-dose chemotherapy (HDC) consisting of single cycle of Busulfan and Thiotepa followed by autologous stem cell rescue without the use of radiation therapy. | 23301664 |
| cytidylyl-(3-5)-cytidine | Stem Cell Exhaustion | Additional studies are necessary to determine the role of HDC and stem cell rescue in patients with recurrent CPC. | 23301664 |
| Myeloid Leukemia | Stem Cell Exhaustion | [Efficacy of allogeneic hematopoietic stem cell transplantation in treatment of childhood myelogenous leukemia: the observation of 24 cases]. | 23302609 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | To retrospectively analyze the effects of allogeneic hematopoietic stem cell transplantation (allo-HSCT) on childhood chronic myelogenous leukemia (CML). | 23302609 |
| Specialty Type - cancer | Stem Cell Exhaustion | Changes in nutritional status, body composition, quality of life, and physical activity levels of cancer patients undergoing autologous peripheral blood stem cell transplantation. | 23306934 |
| Specialty Type - cancer | Stem Cell Exhaustion | This pilot exploratory study aimed to describe the changes in nutritional status, body composition, quality of life (QoL), and physical activity levels (PAL) of cancer patients undergoing high-dose conditioning and autologous peripheral blood stem cell transplantation (PBSCT) at pre-admission, hospital discharge, and at 100 days post-transplantation, and to examine if changes in these parameters are interrelated. | 23306934 |
| Ischemia | Stem Cell Exhaustion | Intra-arterial allogeneic mesenchymal stem cells for critical limb ischemia are safe and efficacious: report of a phase I study. | 23307180 |
| Specialty Type - cancer, Neoplasms, Secondary Neoplasm, Carcinogenesis | Stem Cell Exhaustion | According to the cancer stem cell (CSC) theory, the overexpression of Sox2 is potentially involved in carcinogenesis and could affect tumor recurrence and metastasis. | 23307254 |
| Ischemia | Stem Cell Exhaustion | Molecular imaging of the paracrine proangiogenic effects of progenitor cell therapy in limb ischemia. | 23307829 |
| Ischemia | Stem Cell Exhaustion | Using molecular imaging, we tested the hypothesis that treatment of limb ischemia with multipotential adult progenitor cells (MAPCs) promotes recovery of blood flow through the recruitment of proangiogenic monocytes. | 23307829 |
| Colonization | Stem Cell Exhaustion | Microbiology and epidemiology of oral yeast colonization in hemopoietic progenitor cell transplant recipients. | 23312542 |
| Colonization, Stomatitis | Stem Cell Exhaustion | We monitored the epidemiology and microbiology of oral yeast colonization in patients undergoing hemopoietic progenitor cell transplantation (HPCT) to examine associations between yeast colonization and oral mucositis. | 23312542 |
| Diffuse alveolar hemorrhage, Hematologic Neoplasms | Stem Cell Exhaustion | To analyze high-resolution computed tomography (HRCT) patterns of lung involvement and disease course in patients with hematological malignancies experiencing diffuse alveolar hemorrhage (DAH) after chemotherapy +- allogeneic stem cell transplantation (allo-SCT). | 23313188 |
| Adult Glioblastoma, Specialty Type - cancer | Stem Cell Exhaustion | PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line. | 23314408 |
| Adult Glioblastoma | Stem Cell Exhaustion | Here, ectopic expression of PTEN in the U-87MG human glioblastoma-astrocytoma cell line is shown to result in the depletion of glioblastoma stem cells (GSCs) and to cause growth retardation and senescence. | 23314408 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Azacitidine and donor lymphocyte infusions as first salvage therapy for relapse of AML or MDS after allogeneic stem cell transplantation. | 23314834 |
| Neoplasms, SERPINB3 wt Allele, Specialty Type - cancer | Stem Cell Exhaustion | Tumour cells of a putative CD44+ cancer stem cell compartment express VDR indicating a potential Achilles' heel for the treatment of OSCC although, our results do not allow any conclusion on the function of VDR. | 23314953 |
| Specialty Type - cancer | Stem Cell Exhaustion | Vitrification has been proposed as a promising technique for long-term storage of ITT, with a view to preserving spermatogonial stem cells (SSCs) for future fertility restoration in young boys suffering from cancer. | 23315062 |
| Aplastic Anemia, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Individual hematopoietic stem cells in human bone marrow of patients with aplastic anemia or myelodysplastic syndrome stably give rise to limited cell lineages. | 23316019 |
| Specialty Type - cancer | Stem Cell Exhaustion | Induction of cells with cancer stem cell properties from nontumorigenic human mammary epithelial cells by defined reprogramming factors. | 23318426 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cells (CSCs), a small and elusive population of undifferentiated cancer cells within tumors that drive tumor growth and recurrence, are believed to resemble normal stem cells. | 23318426 |
| HD Term Type, filgrastim | Stem Cell Exhaustion | The human recombinant G-CSF filgrastim has been widely used for the mobilization of CD34(+) stem cells of healthy donors (HD). | 23318540 |
| Richters syndrome", Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Successful allogeneic hematopoietic stem cell transplantation in a young patient with Richter syndrome presenting with chronic lymphocytic leukemia and diffuse large B-cell lymphoma with different cell origins. | 23318862 |
| Aplastic Anemia, CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology | Stem Cell Exhaustion | Antithymocyte globulin (ATG) is the drug of choice for immunosuppressive therapy (IST) in patients with severe aplastic anemia (SAA) ineligible for allogeneic stem cell transplantation. | 23318980 |
| Adult Glioblastoma | Stem Cell Exhaustion | CD133/CD15 defines distinct cell subpopulations with differential in vitro clonogenic activity and stem cell-related gene expression profile in in vitro propagated glioblastoma multiforme-derived cell line with a PNET-like component. | 23319191 |
| Neoplasms | Stem Cell Exhaustion | However, a unique immunophenotype/surface antigen composition for the clear identification of brain tumour stem cells (BTSC) has not yet been found. | 23319191 |
| Leukemia, Myelomonocytic, Chronic | Stem Cell Exhaustion | Allogeneic stem cell transplantation for chronic myelomonocytic leukemia: a report from the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire. | 23320648 |
| Leukemia, Myelomonocytic, Chronic | Stem Cell Exhaustion | Chronic myelomonocytic leukemia (CMML) is a severe disease for which allogeneic stem cell transplantation (allo-SCT) remains the only potentially curative treatment. | 23320648 |
| Leukemia, Myelomonocytic, Chronic | Stem Cell Exhaustion | Allogeneic stem cell transplantation is a valid treatment option for patients with CMML, and its outcome has improved with YOT > 2004. | 23320648 |
| Carcinoma, Papillary, Specialty Type - cancer, Papilloma | Stem Cell Exhaustion | In addition, our data suggest that cyclin D1 is expressed only in the cancer stem or progenitor cells that co-immunostained with CK 8/18 in papillary carcinomas, and predominantly with CK 8/18 in the papillomas. | 23327593 |
| Exfoliative dermatitis, Omenn Syndrome | Stem Cell Exhaustion | A 4-month-old girl diagnosed with Omenn syndrome, a subtype of severe combined immunodeficiency presenting with generalized erythroderma, was referred to our hospital for an allogeneic stem cell transplantation. | 23328788 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Impact of malignant stem cell burden on therapy outcome in newly diagnosed chronic myeloid leukemia patients. | 23328954 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Chronic myeloid leukemia (CML) stem cells appear resistant to tyrosine kinase inhibitors (TKIs) in vitro, but their impact and drug sensitivity in vivo has not been systematically assessed. | 23328954 |
| Philadelphia chromosome positive chronic myelogenous leukemia, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | We prospectively analyzed the proportion of Philadelphia chromosome-positive leukemic stem cells (LSCs, Ph+CD34+CD38-) and progenitor cells (LPCs, Ph+CD34+CD38+) from 46 newly diagnosed CML patients both at the diagnosis and during imatinib or dasatinib therapy (ClinicalTrials.gov NCT00852566). | 23328954 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (HSCT) is an efficacious treatment for many hematologic malignancies. | 23329358 |
| CLU protein, human, Ischemia, diabetic | Stem Cell Exhaustion | The efficacy and safety of transplanting autologous mesenchymal stem cells (MSCs), from granulocyte-colony-stimulating factor (G-CSF)-mobilised peripheral blood, was investigated in diabetic patients with critical limb ischaemia (CLI). | 23329572 |
| Pure Red-Cell Aplasia | Stem Cell Exhaustion | We estimated the incidence and described the natural history of PRCA in patients with major ABO-mismatched donor stem cells. | 23330820 |
| Pure Red-Cell Aplasia | Stem Cell Exhaustion | Between 2007 and 2008, 161 (27% of all patients undergoing HSCT) underwent allogeneic HSCT with major ABO-mismatched stem cells and 12 (7*5%) of these patients developed PRCA. | 23330820 |
| Encephalitis | Stem Cell Exhaustion | Human herpesvirus-6 encephalitis during hematopoietic stem cell transplantation leads to poor prognosis. | 23331378 |
| Encephalitis, Infection | Stem Cell Exhaustion | Indications for the application of hematopoietic stem cell transplantation (HSCT) from alternative donors have remarkably broadened in scope; however, the incidence of infections that lead to failure of HSCT, such as human herpesvirus-6 (HHV-6) encephalitis, has also increased. | 23331378 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | The cancer stem cell marker aldehyde dehydrogenase 1 (ALDH1) associates with treatment resistance and adverse outcome in several human cancers. | 23332924 |
| TCL4 gene, Pregnancy Complications, Infectious | Stem Cell Exhaustion | Distinct clinical features of infectious complications in adult T cell leukemia/lymphoma patients after allogeneic hematopoietic stem cell transplantation: a retrospective analysis in the Nagasaki transplant group. | 23333533 |
| HOX11 protein, TRPV6 wt Allele | Stem Cell Exhaustion | Although allogeneic hematopoietic stem cell transplantation (allo-SCT) is performed as a curative option in adult T cell leukemia-lymphoma (ATL) patients, its high transplantation-related mortality raises a serious issue. | 23333533 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | The superiority of plerixafor + granulocyte colony-stimulating factor (G-CSF) over placebo + G-CSF for hematopoietic stem cell mobilization and collection was shown for patients with non-Hodgkin lymphoma in a phase III, prospective, randomized, controlled study. | 23333777 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Plerixafor plus granulocyte colony-stimulating factor improves the mobilization of hematopoietic stem cells in patients with non-Hodgkin lymphoma and low circulating peripheral blood CD34+ cells. | 23333777 |
| Specialty Type - cancer, Multiple Myeloma | Stem Cell Exhaustion | Factors impacting stem cell mobilization failure rate and efficiency in multiple myeloma in the era of novel therapies: experience at Memorial Sloan Kettering Cancer Center. | 23334269 |
| Failure | Stem Cell Exhaustion | Among 317 patients who proceeded to stem cell collection after induction therapy between 2000 and 2009, the rate of mobilization failure, defined as the inability to collect 5 x 10(6) CD34+ cells/kg following the first collection attempt, was 13%. | 23334269 |
| Hematopoietic stem cells | Stem Cell Exhaustion | Plasma exchange of the recipient is a safe method of managing donor-recipient major ABO incompatibility before BMT without the risk of haematopoietic progenitor cell loss associated with red cell depletion of the graft. | 23334277 |
| Neoplasms | Stem Cell Exhaustion | It is unclear how adult stem cells in solid organs respond to oncogenic stimulation and whether these cells have a role in tumor initiation. | 23334329 |
| Specialty Type - cancer, Pancreatic carcinoma | Stem Cell Exhaustion | The use of a novel MUC1 antibody to identify cancer stem cells and circulating MUC1 in mice and patients with pancreatic cancer. | 23335066 |
| Specialty Type - cancer | Stem Cell Exhaustion | Development of novel approaches for detection and/or targeting of MUC1 are critically needed and should be able to detect MUC1 on PC cells (including cancer stem cells) and in serum. | 23335066 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | PI-103 sensitizes acute myeloid leukemia stem cells to daunorubicin-induced cytotoxicity. | 23335068 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Leukemia stem cells (LSCs) are insensitive to conventional chemotherapeutic drugs and play a central role in the pathogenesis of AML. | 23335068 |
| Minimal Disseminated Disease | Stem Cell Exhaustion | Localized bone lesions require irradiation, whereas young patients with disseminated disease receive intensive treatment with stem cell support. | 23335406 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | [Therapeutic efficacy of allogeneic hematopoietic stem cell transplantation in children with chronic myelogenous leukemia]. | 23336162 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | To investigate the therapeutic efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in children with chronic myelogenous leukemia (CML), and to analyze the possible prognostic factors. | 23336162 |
| Pelvic Organ Prolapse | Stem Cell Exhaustion | We aimed to derive induced pluripotent stem cell (iPSC) lines from vaginal fibroblasts from older women with pelvic organ prolapse. | 23341439 |
| Amyotrophic Lateral Sclerosis | Stem Cell Exhaustion | Differentiation of CD133+ stem cells from amyotrophic lateral sclerosis patients into preneuron cells. | 23341441 |
| Amyotrophic Lateral Sclerosis, Antilymphocyte Serum | Stem Cell Exhaustion | Improvements in quality of life and life expectancy have been observed in amyotrophic lateral sclerosis (ALS) patients transplanted with CD133(+) stem cells into their frontal motor cortices. | 23341441 |
| Antilymphocyte Serum | Stem Cell Exhaustion | The objective of this work was to evaluate the in vitro capacity of CD133(+) stem cells from 13 ALS patients to differentiate into neuron lineage. | 23341441 |
| Antilymphocyte Serum | Stem Cell Exhaustion | Fluorescence microscopy demonstrated that CD133(+) stem cells from ALS patients incubated for 48 hours in a neuroinduction medium increased the detection of neuronal proteins such as nestin, b-tubulin III, neuronal-specific enolase, and glial fibrillary acidic protein. | 23341441 |
| Antilymphocyte Serum | Stem Cell Exhaustion | We conclude that CD133(+) stem cells from ALS patients, like the stem cells of healthy subjects, are capable of differentiating into preneuron cells. | 23341441 |
| Multiple Myeloma | Stem Cell Exhaustion | Early response to bortezomib combined chemotherapy can help predict survival in patients with multiple myeloma who are ineligible for stem cell transplantation. | 23341716 |
| Idiopathic Pulmonary Fibrosis | Stem Cell Exhaustion | Endothelial progenitor cells in the pathogenesis of idiopathic pulmonary fibrosis: an evolving concept. | 23341966 |
| diabetic, Foot Diseases | Stem Cell Exhaustion | This study was designed to evaluate the distribution of Tregs/Th17/Th1 cells in type 2 diabetic patients with foot disease before and after human umbilical cord blood mesenchymal stem cell (hUCB-MSCs) transplantation. | 23343120 |
| Umbilical Cord Blood-Derived Mesenchymal Stem Cells, Immunology, Foot Diseases, Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Treatment of foot disease in patients with type 2 diabetes mellitus using human umbilical cord blood mesenchymal stem cells: response and correction of immunological anomalies. | 23343120 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation versus hypomethylating agents in patients with myelodysplastic syndrome: a retrospective case-control study. | 23345254 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Allogeneic stem cell transplantation (allo-SCT) is the only potentially curative treatment for myelodysplastic syndrome (MDS). | 23345254 |
| Pancytopenia | Stem Cell Exhaustion | Treatment at home during the pancytopenic phase after allogeneic hematopoietic stem cell transplantation (HSCT) has been an option for patients at our center since 1998. | 23347992 |
| Mycoses | Stem Cell Exhaustion | Invasive fungal infections are a major cause of morbidity and mortality in hematopoietic stem cell transplantation patients. | 23350288 |
| Fusariosis | Stem Cell Exhaustion | We report a case of invasive Fusarium infection involving the nasopharynx, skin and lungs, following haploidentical hematopoietic stem cell transplantation in an 8-year old patient with recurrent leukemia. | 23350288 |
| Malignant tumor of colon | Stem Cell Exhaustion | MicroRNA-93 (miR-93) has been shown to suppress proliferation and colony formation of colon cancer stem cells. | 23354160 |
| Neoplasms | Stem Cell Exhaustion | We found that CD44(+)/aldehyde dehydrogenase (ALDH)(+) slowly proliferating immature CRC stem cell populations expressed relatively low levels of JARID1B and the differentiation marker, CD20, as well as relatively high levels of the tumor suppressor, p16/INK4A. | 23354547 |
| Specialty Type - cancer, Secondary Neoplasm, Cytogenetic Complete Response | Stem Cell Exhaustion | Although there are emerging epigenetic factors that contribute to the occurrence, development and metastasis of CRC, the biological significance of epigenetic molecular regulation in different subpopulations such as cancer stem cells remains to be elucidated. | 23354547 |
| diabetic, Corneal Endothelial Cell Loss | Stem Cell Exhaustion | Eighteen "responder" and twelve "non responder" type 2 diabetic patients were evaluated, relatively to different levels of endothelial damage, through the diagnostic use of a new immunophenotype of circulating endothelial progenitor cells (CD45neg/CD34pos/CD144pos) and endothelial microparticles (CD45neg/CD144pos/Annexin Vpos), recently developed and published by our group. | 23357410 |
| Penile arterial insufficiency, Erectile dysfunction | Stem Cell Exhaustion | "Non responder" patients showed a significant higher severity [8.0+-3.0 (International Index of Erectile Function-abbreviated version with 5 questions) vs 14.0+-3.0] and duration (10.0+-2.0 vs 7.0+-2.0 years) of erectile dysfunction, higher level of penile arterial insufficiency (peak systolic velocity=13.0+-16.0 vs 28.0+-26.0cm/s; acceleration time=153+-148 vs 125+-128 mm/s) and finally a significant higher level of endothelial apoptosis [0.15+-0.13 vs 0.05+-.0.03% (serum concentrations of endothelial microparticles)] associated with higher serum concentrations of circulating late immunophenotype of endothelial progenitor cells (0.40+-0.35 vs 0.12+-.0.10%). | 23357410 |
| Multiple Myeloma | Stem Cell Exhaustion | Overcoming the response plateau in multiple myeloma: a novel bortezomib-based strategy for secondary induction and high-yield CD34+ stem cell mobilization. | 23357980 |
| Multiple Myeloma | Stem Cell Exhaustion | This phase II study evaluated bortezomib-based secondary induction and stem cell mobilization in 38 transplant-eligible patients with myeloma who had an incomplete and stalled response to, or had relapsed after, previous immunomodulatory drug-based induction. | 23357980 |
| Neoplasms | Stem Cell Exhaustion | Bortezomib-based secondary induction and mobilization could represent an alternative strategy for elimination of tumor burden in immunomodulatory drug-resistant patients that does not impact stem cell yield. | 23357980 |
| Gray Platelet Syndrome | Stem Cell Exhaustion | Successful hematopoietic engraftment with gray platelets after allogeneic hematopoietic stem cell transplantation from gray platelet syndrome donor. | 23358204 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | A 19-year old female patient with her second relapse acute lymphoblastic leukemia had to be consolidated with allo-hematopoietic stem cell transplantation (HSCT) after achieving remission with induction chemotherapy. | 23358204 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Our previous work showed thiotepa could eradicate breast cancer stem cells. | 23359185 |
| Arca | Stem Cell Exhaustion | Comparative analysis of circulating endothelial progenitor cells in age-related macular degeneration patients using automated rare cell analysis (ARCA) and fluorescence activated cell sorting (FACS). | 23359346 |
| Idiopathic pneumonia syndrome | Stem Cell Exhaustion | Successful use of extracorporeal membrane oxygenation in a hematopoietic stem cell transplant patient with idiopathic pneumonia syndrome. | 23359731 |
| Allogeneic Hematopoietic Stem Cell Transplantation, Idiopathic pneumonia syndrome | Stem Cell Exhaustion | We report the case of an adult patient with idiopathic pneumonia syndrome following allogeneic hematopoietic stem cell transplantation, which was successfully managed with venovenous extracorporeal membrane oxygenation (ECMO) and immunosuppressive therapy. | 23359731 |
| leukemia | Stem Cell Exhaustion | He underwent allogeneic hematopoietic stem cell transplantation 4 months prior to enrollment, owing to leukemia relapse. | 23359731 |
| T-Cell Lymphoma | Stem Cell Exhaustion | Autologous stem cell transplantation for enteropathy-associated T-cell lymphoma: a retrospective study by the EBMT. | 23361910 |
| TRPV6 wt Allele | Stem Cell Exhaustion | Autologous stem cell transplantation (ASCT) was retrospectively evaluated as a consolidation or salvage strategy for EATL. | 23361910 |
| Vascular System Injuries | Stem Cell Exhaustion | Vessel injury was observed in a total of 9 procedures (1.2%) and could be promptly managed by additional progenitor cell injection (PCI) in all but 1 case. | 23362308 |
| Chronic heart failure, Acute myocardial infarction | Stem Cell Exhaustion | Procedural safety and predictors of acute outcome of intracoronary administration of progenitor cells in 775 consecutive procedures performed for acute myocardial infarction or chronic heart failure. | 23362308 |
| Congestive heart failure, Acute myocardial infarction | Stem Cell Exhaustion | Intracoronary infusion of progenitor cells can be performed with adequate safety in patients with acute myocardial infarction or CHF, because the safety profile was similar to what is usually expected from a coronary angiogram in the present cohort. | 23362308 |
| TNF protein, human | Stem Cell Exhaustion | PFS was inversely correlated with baseline levels of VEGF, sVEGFR2, and bFGF and with on-treatment levels of bFGF and IGF-1, and directly associated with on-treatment levels of IFN-g. OS was inversely correlated with baseline levels of sVEGFR1, Ang-2, TNF-a, CAIX, and CD34(+)CD133(+)CD45(dim) circulating progenitor cells and on-treatment levels of sVEGFR2. | 23362324 |
| Specialty Type - cancer | Stem Cell Exhaustion | Human cancer cells resemble stem cells in expression signatures leading them to share some features, most notably, self-renewal. | 23363002 |
| Colorectal Neoplasms | Stem Cell Exhaustion | SALL4 is a zinc finger transcriptional activator crucial for maintenance of self-renewal in stem cells; however, its expression level has not yet been elucidated in colorectal tumor cells. | 23363002 |
| Systemic Scleroderma | Stem Cell Exhaustion | Cardiac involvement and treatment-related mortality after non-myeloablative haemopoietic stem-cell transplantation with unselected autologous peripheral blood for patients with systemic sclerosis: a retrospective analysis. | 23363664 |
| Failure, Systemic Scleroderma | Stem Cell Exhaustion | Autologous haemopoietic stem-cell transplantation (HSCT) benefits patients with systemic sclerosis but has been associated with significant treatment-related mortality and failure to improve diffusion capacity of carbon monoxide (DLCO). | 23363664 |
| Acute leukemia | Stem Cell Exhaustion | [Outcome of haploidentical hematopoietic stem cell transplantation for refractory/relapsed acute leukemia]. | 23363748 |
| Acute leukemia | Stem Cell Exhaustion | To explore the outcome of human leukocyte antigen (HLA)-mismatched/haploidentical hematopoietic stem cell transplantation (HSCT) for refractory/relapsed acute leukemia (AL) patients and its related risk factors. | 23363748 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | This study was aimed to investigate whether incorporation of rituximab into high-dose chemotherapy with autologous peripheral blood stem cell transplantation (auto-PBSCT)could improve the survival of patients with diffuse large B-cell lymphoma (DLBCL), and evaluate the safety of this regimen. | 23363798 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | Twenty-five patients (age, 17 - 61 yrs) with DLBCL were treated with a sequential chemotherapy for remission induction, intensive chemotherapy for mobilization of stem cells, and high-dose chemotherapy followed by auto-PBSCT. | 23363798 |
| Bulbo-Spinal Atrophy, X-Linked | Stem Cell Exhaustion | Enhanced aggregation of androgen receptor in induced pluripotent stem cell-derived neurons from spinal and bulbar muscular atrophy. | 23364790 |
| Disease | Stem Cell Exhaustion | Induced pluripotent stem cells (iPSCs) are a new technology that can be used to model human diseases, study pathogenic mechanisms, and develop novel drugs. | 23364790 |
| Acute lymphocytic leukemia, BCR gene | Stem Cell Exhaustion | To analyse the outcome of adult patients who developed a first relapse of acute lymphoblastic leukaemia (ALL), we collected the clinical data of 332 patients with Philadelphia-chromosome (Ph) negative ALL, aged 16-65 years, who relapsed after first complete remission (CR1) between 1998 and 2008 in 69 institutions all over Japan, including 58 patients who relapsed after allogeneic haematopoietic stem cell transplantation (Allo-HSCT) in CR1. | 23368421 |
| Specialty Type - cancer | Stem Cell Exhaustion | Using crude EVOO phenolic extracts highly enriched in the secoiridoids oleuropein aglycon and decarboxymethyl oleuropein aglycon, we show for the first time that (1) the anticancer activity of EVOO secoiridoids is related to the activation of anti-aging/cellular stress-like gene signatures, including endoplasmic reticulum (ER) stress and the unfolded protein response, spermidine and polyamine metabolism, sirtuin-1 (SIRT1) and NRF2 signaling; (2) EVOO secoiridoids activate AMPK and suppress crucial genes involved in the Warburg effect and the self-renewal capacity of "immortal" cancer stem cells; (3) EVOO secoiridoids prevent age-related changes in the cell size, morphological heterogeneity, arrayed cell arrangement and senescence-associated b-galactosidase staining of normal diploid human fibroblasts at the end of their proliferative lifespans. | 23370395 |
| Acute lymphocytic leukemia, BCR gene | Stem Cell Exhaustion | We aimed to clarify the impact of the donor source of allogeneic stem cell transplantation (allo-SCT) on Philadelphia chromosome-negative acute lymphoblastic leukemia [Ph(-) ALL] with focus on cord blood (CB). | 23372050 |
| Paroxysmal nocturnal hemoglobinuria | Stem Cell Exhaustion | Because in PNH the biosynthesis of the glycolipid molecule glycosylphosphatidylinositol (GPI) is disrupted in hematopoietic stem and progenitor cells by a somatic mutation in the PIG-A gene, BMF might result from an autoimmune attack, whereby T cells target GPI in normal cells, whereas PIG-A mutant GPI-negative cells are spared. | 23372165 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Mesenchymal stem cell injections improve symptoms of knee osteoarthritis. | 23375182 |
| Degenerative polyarthritis | Stem Cell Exhaustion | The purpose of this study was to evaluate the clinical and imaging results of patients who received intra-articular injections of autologous mesenchymal stem cells for the treatment of knee osteoarthritis. | 23375182 |
| Degenerative polyarthritis, Usual Severity Pain | Stem Cell Exhaustion | The results of our study are encouraging and show that intra-articular injection of infrapatellar fat pad-derived mesenchymal stem cells is effective for reducing pain and improving knee function in patients being treated for knee osteoarthritis. | 23375182 |
| Pseudarthrosis | Stem Cell Exhaustion | Treatment of pseudoarthrosis of the upper limb using expanded mesenchymal stem cells: a pilot study. | 23377812 |
| Heart failure, Cessation of life | Stem Cell Exhaustion | Comparison of the Seattle heart failure model and cardiopulmonary exercise capacity for prediction of death in patients with chronic ischemic heart failure and intracoronary progenitor cell application. | 23377956 |
| Heart failure | Stem Cell Exhaustion | One hundred fifty-seven patients with ischemic heart failure and recent intracoronary progenitor cell application were analyzed for mortality during a follow-up of 4 years. | 23377956 |
| Gastric Antral Vascular Ectasia, Gastrointestinal Hemorrhage, Agave | Stem Cell Exhaustion | Gastric antral vascular ectasia (GAVE) leading to upper gastrointestinal bleeding is a heterogeneous disorder that is not commonly recognized in hematopoietic stem cell transplantation (HSCT). | 23378184 |
| Inflammation | Stem Cell Exhaustion | S100 proteins, and in particular S100 A4 and S100 A9, can be useful as markers of early changes in stem cell niches due to inflammation. | 23378728 |
| Graft-vs-Host Disease, Hematologic Neoplasms, Failure | Stem Cell Exhaustion | Allogeneic stem cell transplantation (SCT) is the most effective treatment option for many hematologic malignancies, but graft-versus-host disease (GVHD) remains a major cause of treatment failure. | 23380341 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Central line-associated blood stream infections (CLABSI) commonly complicate the care of patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) after allogeneic stem cell transplantation (HCT). | 23380342 |
| Comorbidity | Stem Cell Exhaustion | The median age at transplantation was 52 years (range, 16 to 70); 34 had a high (>=3) HCT comorbidity index (HCT-CI); 34 received bone marrow (BM), 24 received peripheral stem cells (PSC), and 15 received umbilical cord blood cells (UCB). | 23380342 |
| Ischemia | Stem Cell Exhaustion | Bone marrow alterations and lower endothelial progenitor cell numbers in critical limb ischemia patients. | 23383236 |
| Endothelium | Stem Cell Exhaustion | Blood levels of markers for endothelial injury (sE-selectin, sICAM-1, sVCAM-1, and thrombomodulin), and progenitor cell mobilizing and inflammatory factors were assessed by conventional and multiplex ELISA. | 23383236 |
| CLU protein, human | Stem Cell Exhaustion | The results of this study suggest that inflammation-induced BM exhaustion and a disturbed progenitor cell mobilization response due to reduced levels and activity of MMP-9 in the BM and alterations in the SDF-1a/CXCR4 interaction contribute to the attenuated neovascularization in CLI patients. | 23383236 |
| Pathologic Neovascularization, CLU protein, human | Stem Cell Exhaustion | We hypothesize that reduced levels and function of circulating progenitor cells and alterations in the BM contribute to impaired neovascularization in CLI. | 23383236 |
| Neoplasms | Stem Cell Exhaustion | In the latter, tumor cells are quite similar to enterochromaffin granule containing crypt cells, which are regarded as their progenitor cells. | 23383615 |
| Multiple Myeloma | Stem Cell Exhaustion | Salvage autologous stem cell transplantation for multiple myeloma relapsing or progressing after up-front autologous transplantation. | 23387937 |
| Experimental Organism Malignant Hepatocholangiocellular Carcinoma | Stem Cell Exhaustion | Ten, 1, 32, and 11 cases were diagnosed as: combined hepatocellular-cholangiocarcinoma, classical type; combined hepatocellular-cholangiocarcinoma, stem cell features, typical subtype; combined hepatocellular-cholangiocarcinoma, stem cell features, intermediate cell subtype; and combined hepatocellular-cholangiocarcinoma, stem cell features, cholangiolocellular type, respectively. | 23388123 |
| Experimental Organism Malignant Hepatocholangiocellular Carcinoma | Stem Cell Exhaustion | The expression of CD133 and vimentin was observed only in combined hepatocellular-cholangiocarcinoma, stem cell features of intermediate cell subtype and cholangiolocellular subtype. | 23388123 |
| Experimental Organism Malignant Hepatocholangiocellular Carcinoma | Stem Cell Exhaustion | The expression of CD133, EpCAM, and vimentin was significantly high in combined hepatocellular-cholangiocarcinoma, subtypes with stem cell features, especially cholangiolocellular subtype. | 23388123 |
| Experimental Organism Malignant Hepatocholangiocellular Carcinoma | Stem Cell Exhaustion | Minor histologic patterns were significantly frequent in combined hepatocellular-cholangiocarcinoma, subtypes with stem cell features, compared with combined hepatocellular-cholangiocarcinoma, classical type. | 23388123 |
| Ischemia, Diabetic Foot | Stem Cell Exhaustion | Both autologous bone marrow mononuclear cell and peripheral blood progenitor cell therapies similarly improve ischaemia in patients with diabetic foot in comparison with control treatment. | 23390092 |
| Ischemia, Diabetic Foot | Stem Cell Exhaustion | The aim of our study was to compare the effect of bone marrow mononuclear cell and peripheral blood progenitor cell therapies in patients with diabetic foot disease and critical limb ischaemia unresponsive to revascularization with conservative therapy. | 23390092 |
| Kidney Failure, Proteinuria | Stem Cell Exhaustion | A 7-year-old boy with renal insufficiency and proteinuria after stem cell transplant for T-cell acute lymphoblastic leukemia. | 23391318 |
| Chronic Kidney Disease, CTCAE | Stem Cell Exhaustion | Chronic kidney disease is common in pediatric patients following hematopoietic stem cell transplant. | 23391318 |
| Graft-vs-Host Disease, Nephrotic Syndrome, Nuclear non-senile cataract | Stem Cell Exhaustion | Graft vs. host disease (GVHD) is a common sequela of hematopoietic stem cell transplant and has been associated with the nephrotic syndrome (NS). | 23391318 |
| Kidney Failure, Proteinuria | Stem Cell Exhaustion | Here we report a case of a pediatric patient who developed proteinuria and renal insufficiency after stem cell transplant. | 23391318 |
| leukemia, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | This study examined the course of neuropsychological functioning in patients with chronic myelogeous leukemia (n = 91) or myelodysplastic syndrome (n = 15) who underwent standard treatment for their disease or allogeneic hematopoietic stem cell transplantation (HSCT) at baseline, 12 months, and 18 months post-treatment. | 23391504 |
| Multiple Myeloma | Stem Cell Exhaustion | [Effect of bortezomib-based induction therapy on the peripheral blood stem cell harvest in multiple myeloma]. | 23391654 |
| Multiple Myeloma | Stem Cell Exhaustion | A high dose of melphalan followed by autologous stem cell transplantation (ASCT) is considered as the standard therapy for multiple myeloma. | 23391654 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Long-term clinical and molecular remissions in patients with follicular lymphoma following high-dose therapy and autologous stem cell transplantation. | 23393125 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Long-term clinical and molecular remissions in patients with follicular lymphoma (FL) following high-dose therapy (HDT) and autologous stem cell transplantation (ASCT) have been evaluated in only a few studies. | 23393125 |
| Hypoxic-Ischemic Encephalopathy | Stem Cell Exhaustion | Environmental enrichment synergistically improves functional recovery by transplanted adipose stem cells in chronic hypoxic-ischemic brain injury. | 23394350 |
| Brain Injuries, Hawaii, Hypoxic-Ischemic Encephalopathy | Stem Cell Exhaustion | We investigated the effects of environmental enrichment (EE) on the function of transplanted adipose stem cells (ASCs) and the combined effect of EE and ASC transplantation on neurobehavioral function in an animal model of chronic hypoxic-ischemic (HI) brain injury. | 23394350 |
| Liver Failure, Acute | Stem Cell Exhaustion | Therapeutic potential of human induced pluripotent stem cell-derived mesenchymal stem cells in mice with lethal fulminant hepatic failure. | 23394436 |
| Liver Failure, Acute | Stem Cell Exhaustion | This study aims to produce MSCs from human induced pluripotent stem cells (hiPSCs) and to evaluate their therapeutic effects in a CCl4-induced mouse model of fulminant hepatic failure (FHF). | 23394436 |
| Adult Glioblastoma, Neoplasms | Stem Cell Exhaustion | MicroRNA-153 is tumor suppressive in glioblastoma stem cells. | 23397238 |
| Neoplasms, Glioblastoma | Stem Cell Exhaustion | Glioblastoma multiforme (GBM) is lethal brain tumor thought to arise from GBM stem cells (GBM-SCs). | 23397238 |
| Parkinson Disease | Stem Cell Exhaustion | Characterization of peripheral hematopoietic stem cells and monocytes in Parkinson's disease. | 23401086 |
| Nerve Degeneration | Stem Cell Exhaustion | This study investigated the impact of progressive neurodegeneration on the differentiation and development of hematopoietic stem cells in the peripheral blood of Parkinson's patients. | 23401086 |
| Parkinson Disease | Stem Cell Exhaustion | A colony-forming cell assay was established to study hematopoietic stem cells from venous blood of Parkinson's patients, and flow cytometry was used to analyze the expression of chemokine receptors on monocytes. | 23401086 |
| Chronic myeloproliferative disorder, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasia arising from the oncogenic break point cluster region/Abelson murine leukemia viral oncogene homolog 1 translocation in hematopoietic stem cells (HSCs), resulting in a leukemia stem cell (LSC). | 23401488 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Cytotoxic T cells induce proliferation of chronic myeloid leukemia stem cells by secreting interferon-g. | 23401488 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | In addition, IFN-g increased proliferation and colony formation of CD34(+) stem/progenitor cells from CML patients in vitro. | 23401488 |
| Comorbidity | Stem Cell Exhaustion | We thus retrospectively analyzed 14 patients with primary refractory or relapsed HL who were treated with brentuximab vedotin as single agent in a named patient program, who had not received prior high-dose chemotherapy (HDCT) and autologous stem cell transplant (ASCT) due to refractory disease (n = 9), comorbidity (n = 4) and unknown reasons (n = 1). | 23402268 |
| Specialty Type - cancer, Colorectal Carcinoma, Neoplasms | Stem Cell Exhaustion | CD44 standard isoform (CD44s) is a cancer stem cell marker in many tumors, and is one of the CD44 isoforms.CD44v6 has been reported to correlate with tumor progression and poor prognosis in colorectal cancer. | 23404221 |
| Neoplasms | Stem Cell Exhaustion | Blood was collected for pharmacokinetic analysis and measurements of circulating tumor cells and circulating endothelial (progenitor) cells (CE(P)Cs). | 23404627 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Tetrathiomolybdate-associated copper depletion decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse. | 23406736 |
| PAFAH1B1 wt Allele, Decreased platelet count | Stem Cell Exhaustion | This research shows a hypoplastic thrombocytopenia that platelets from MDS patients possess an impaired ability to be stimulated and more apoptosis markers than those from healthy controls, indicating that MDS is a stem cell disorder, and then, both number and function of progeny cells, might be affected. | 23407717 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Patients with myelodysplastic syndromes (MDS) have a defect in the differentiation of bone marrow multipotent progenitor cells. | 23407717 |
| Kidney Failure, Acute | Stem Cell Exhaustion | In acute kidney injury, indoxyl sulfate impairs human endothelial progenitor cells: modulation by statin. | 23408148 |
| Kidney Failure, Acute, Ischemia of kidney | Stem Cell Exhaustion | Renal ischemia rapidly mobilizes endothelial progenitor cells (EPCs), which provides renoprotection in acute kidney injury (AKI). | 23408148 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Recent studies indicate the presence of pre-existing BCR-ABL mutations in a higher percentage of CML patients when CD34+ stem/progenitor cells are investigated using sensitive techniques, and these mutations are associated with imatinib resistance and disease progression. | 23409026 |
| Acute Coronary Syndrome | Stem Cell Exhaustion | In vitro characterization of circulating endothelial progenitor cells isolated from patients with acute coronary syndrome. | 23409178 |
| Cardiovascular Diseases | Stem Cell Exhaustion | The current understanding of the functional characteristics of circulating endothelial progenitor cells (EPC) is limited, especially in patients affected by cardiovascular diseases. | 23409178 |
| Toxic effect, LIPC gene | Stem Cell Exhaustion | This retrospective study evaluated the efficacy and toxicity of bendamustine in 28 patients with refractory HL or relapsed HL after autologous stem cell transplant (ASCT) used as part of a compassionate use program. | 23410099 |
| Cardiomyopathies | Stem Cell Exhaustion | Studies in animals have proposed the cardiac progenitor cells (CPCs) as the cellular target responsible for DOXO-induced cardiomyopathy but the relevance of these observations to clinical settings is unknown. | 23411815 |
| Specialty Type - cancer | Stem Cell Exhaustion | This cross sectional study included 141 cancer patients who underwent chemotherapy or hematopoietic progenitor cell transplantation and received platelet transfusions at The University of Texas M.D. | 23416822 |
| Neoplasms | Stem Cell Exhaustion | Tumor cells that express CD44 and CD24 exhibit a stem-cell-like behavior. | 23419168 |
| Communicable Diseases | Stem Cell Exhaustion | Human cytomegalovirus (HCMV) infection causes significant morbidity and mortality after hematopoietic stem cell transplantation (HSCT). | 23424600 |
| Nasopharyngeal carcinoma | Stem Cell Exhaustion | Embryonic stem cells markers SOX2, OCT4 and Nanog expression and their correlations with epithelial-mesenchymal transition in nasopharyngeal carcinoma. | 23424657 |
| Malignant Neoplasms | Stem Cell Exhaustion | Expression of embryonic stem cells (ESCs) markers (SOX2, OCT4, Nanog and Nestin) is crucial for progression of various human malignancies. | 23424657 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Outcome of patients with transformed indolent non-Hodgkin lymphoma referred for autologous stem-cell transplantation. | 23425946 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | The proportion of potentially eligible patients with transformed indolent non-Hodgkin lymphoma who undergo autologous stem-cell transplantation (ASCT) is unknown. | 23425946 |
| Class Cestoda | Stem Cell Exhaustion | Although adult pluripotent stem cells, called neoblasts, drive long-term homeostatic tissue maintenance in long-lived free-living flatworms (for example, planarians), and neoblast-like cells have been described in some parasitic tapeworms, little is known about whether similar cell types exist in any trematode species. | 23426263 |
| Aplastic Anemia | Stem Cell Exhaustion | Effect of kidney-reinforcing, blood-activating and stasis-removing recipes on adhesion molecule expression of bone marrow mesenchymal stem cells from chronic aplastic anemia patients. | 23427395 |
| Aplastic Anemia | Stem Cell Exhaustion | To explore the effect of kidney-reinforcing, blood-activating and stasis-removing recipes on adhesion molecule expression of bone marrow mesenchymal stem cells (MSCs) from patients with chronic aplastic anemia (CAA). | 23427395 |
| Cerebral Atherosclerosis | Stem Cell Exhaustion | Decreased levels of angiogenic growth factors in intracranial atherosclerotic disease despite severity-related increase in endothelial progenitor cell counts. | 23429001 |
| Heart failure, Ischemic cardiomyopathy | Stem Cell Exhaustion | These data highlight the importance of defining the molecular mechanisms of stem cell-based tissue repair and suggest that overexpression of stromal cell-derived factor-1 via gene therapy is a strategy for improving heart failure symptoms in patients with ischemic cardiomyopathy. | 23429605 |
| Hematologic Neoplasms, Neoplasms, Aplastic Anemia | Stem Cell Exhaustion | The underlying disease was hematological malignancy and disorders in 76.3 % (29 cases), solid tumors in 15.8 % (six cases), aplastic anemia in 7.9 % (three cases), while 18.4 % (seven cases) were hematopoietic stem cell transplantation (HSCT) recipients. | 23430671 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Impact of allogeneic haematopoietic stem cell transplantation in patients with abnl(17p) acute myeloid leukaemia. | 23432431 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The role of allogeneic stem cell transplantation (HSCT) as compared to chemotherapy in acute myeloid leukaemia (AML) patients with abnormalities of chromosome 17p [abnl(17p)] has not yet been defined. | 23432431 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | The purpose of this analysis was to provide 6-year follow-up of the CLL3X trial, which studied reduced-intensity allogeneic hematopoietic stem cell transplantation (HSCT) in patients with poor-risk chronic lymphocytic leukemia (CLL), and to investigate the effect of TP53, SF3B1, and NOTCH1 mutations on HSCT outcome. | 23435461 |
| Graft-vs-Host Disease, Allogeneic Hematopoietic Stem Cell Transplantation | Stem Cell Exhaustion | Diagnosis and evaluation of intestinal graft-versus-host disease after allogeneic hematopoietic stem cell transplantation following reduced-intensity and myeloablative conditioning regimens. | 23435651 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Colonoscopic evaluation of mucosal tissues after allogeneic hematopoietic stem cell transplantation (HSCT) is very useful in evaluating pathogenesis and diagnosis of intestinal graft-versus-host disease (GVHD). | 23435651 |
| Hepatitis B, Multiple Myeloma | Stem Cell Exhaustion | Hepatitis B virus infection status is an independent risk factor for multiple myeloma patients after autologous hematopoietic stem cell transplantation. | 23436046 |
| Morular Metaplasia of the Endometrium, Hepatitis B, Multiple Myeloma, Communicable Diseases | Stem Cell Exhaustion | The purposes of this study were to evaluate the infection by hepatitis B virus (HBV) and its impact on survival and to provide a clinical reference for monitoring and treating HBV during and after autologous hematopoietic stem cell transplantation (ASCT) in patients with multiple myeloma (MM). | 23436046 |
| Nephrosis, Immune System Diseases | Stem Cell Exhaustion | The patient's course supports suggestions that immunological dysfunction in nephrosis is associated with abnormality of immature, relatively unclassified T cells (CD34(+)) representing hematopoietic stem cells, as opposed to mature T cells (CD34(-)). | 23436177 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Patients with higher-risk disease have a higher risk of progression to AML and are treated with hypomethylating agents (azacitidine or decitabine) and allogeneic stem cell transplantation if appropriate. | 23436197 |
| Pancreatic carcinoma | Stem Cell Exhaustion | LGR5 and Nanog identify stem cell signature of pancreas beta cells which initiate pancreatic cancer. | 23438436 |
| Respiratory Syncytial Virus Infections | Stem Cell Exhaustion | We compared HRSV infections among Haematopoietic Stem Cell Transplant program (HSCT) patients and children using direct immunofluorescence (DFA), point-of-care RSV Bio Easy(r) and a polymerase chain reaction (PCR) assay. | 23440127 |
| Inflammation | Stem Cell Exhaustion | Pathological changes of the anatomical structure and markers of the limbal stem cell niche due to inflammation. | 23441125 |
| Post-transplant lymphoproliferative disorder | Stem Cell Exhaustion | Hematopoietic stem cell and solid organ transplant recipients diagnosed with biopsy-confirmed posttransplant lymphoproliferative disorder (PTLD) at our institution from 1989 to 2010 were identified. | 23442063 |
| Multiple Myeloma | Stem Cell Exhaustion | Antibody titers >= 1 : 40 persisted for 50% of responding patients at 1 yr. Seroconversion was observed in 69% of 14 patients who had undergone hematopoietic stem cell transplantation and in all (9/9) patients with myeloma (five with ongoing treatment including high-dose corticosteroids). | 23444982 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | CD133 was recently reported to be a cancer stem cell marker and a prognostic marker for several tumors. | 23448401 |
| Pancreatic carcinoma | Stem Cell Exhaustion | We evaluated AGS-1C4D4, a fully human monoclonal antibody to prostate stem cell antigen (PSCA), with gemcitabine in a randomized, phase II study of metastatic pancreatic cancer. | 23448807 |
| Aplastic Anemia | Stem Cell Exhaustion | In vivo T-cell depletion with alemtuzumab in allogeneic hematopoietic stem cell transplantation: Combined results of two studies on aplastic anemia and HLA-mismatched haploidentical transplantation. | 23450467 |
| Aplastic Anemia | Stem Cell Exhaustion | We evaluated the efficacy of in vivo T-cell depletion with alemtuzumab in two prospective studies according to the International Conference on Harmonisation (ICH)-Good Clinical Practice (ICH-GCP) guidelines; one was for patients with aplastic anemia (AA study) and the other was for patients who were undergoing hematopoietic stem cell transplantation (HSCT) from a 2- or 3-antigen-mismatched haploidentical donor (MM study). | 23450467 |
| methyldopa | Stem Cell Exhaustion | Recently a clinical trial was approved by FDA to investigate the safety and efficacy of the human embryonic stem cell-derived retinal pigment epithelium (RPE) transplantation in sub-retinal space of patients with dry AMD These studies suggest that stem cell research may provide both insight regarding disease development and progression, as well as direction for therapeutic innovation for the millions of patients afflicted with AMD. | 23452406 |
| Multiple Myeloma | Stem Cell Exhaustion | A phase 1 study of bendamustine and melphalan conditioning for autologous stem cell transplantation in multiple myeloma. | 23454184 |
| Toxic effect, Multiple Myeloma | Stem Cell Exhaustion | We hypothesized that adding bendamustine to autologous stem cell transplant conditioning in myeloma would enhance response without significant additional toxicity. | 23454184 |
| Multiple Myeloma | Stem Cell Exhaustion | Six patients (24%) with pre-existing high-risk disease died from progressive myeloma during study follow-up, all at or beyond 100 days after autologous stem cell transplant. | 23454184 |
| Toxic effect, Multiple Myeloma | Stem Cell Exhaustion | Bendamustine up to a dose of 225 mg/m(2) added to autologous stem cell transplantation conditioning with high-dose melphalan in patients with multiple myeloma did not exacerbate expected toxicities. | 23454184 |
| Pulmonary Infiltrate | Stem Cell Exhaustion | Utility of flexible bronchoscopy in the evaluation of pulmonary infiltrates in the hematopoietic stem cell transplant population -- a single center fourteen year experience. | 23455477 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | Other chemotherapeutics and novel treatments, such as autologous stem cell transplantation, are being studied for potential use in PCNSL. | 23456261 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Impact of cardiac stem cell sheet transplantation on myocardial infarction. | 23459789 |
| Hepatic Encephalopathy | Stem Cell Exhaustion | Tacrolimus-associated posterior reversible encephalopathy syndrome in hematopoietic allogeneic stem cell transplantation. | 23460378 |
| Encephalopathy, CTCAE 5.0, Posterior reversible encephalopathy syndrome | Stem Cell Exhaustion | Tacrolimus-associated posterior reversible encephalopathy syndrome (PRES) is a potential complication of allogeneic stem cell transplant (SCT). | 23460378 |
| Multiple Myeloma | Stem Cell Exhaustion | Long-term outcome after allogeneic stem-cell transplantation with reduced-intensity conditioning in patients with multiple myeloma. | 23460414 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | A total of 53 patients with multiple myeloma (MM) who received allogeneic hematopoietic stem-cell transplantation (Allo-SCT) between January 2000 and January 2007 were identified. | 23460414 |
| Neoplasms | Stem Cell Exhaustion | Tumour cells were consistently devoid of efflux properties regardless of their genetic background, tumour ploidy or stem cell associated marker expression. | 23460667 |
| Communicable Diseases | Stem Cell Exhaustion | Human herpesvirus type 6 DNAemia and infection following allogeneic stem cell transplantation with a focus on long-term outcome. | 23461659 |
| Communicable Diseases | Stem Cell Exhaustion | Cases of human herpesvirus type 6 (HHV-6) infection and disease were retrospectively analysed in a cohort of 97 allogeneic haematopoietic stem cell transplantation (allo-SCT) patients in Gothenburg, Sweden (1997-2001). | 23461659 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Low-dose alemtuzumab vs. standard policy for prevention of graft-versus-host disease in unrelated and related allogeneic stem cell transplantation-a matched pair analysis. | 23463451 |
| Hematologic Neoplasms, Neoplasms | Stem Cell Exhaustion | Fifty-one percent had solid tumors, 32% had hematological malignancies, and 17% underwent stem cell transplantation. | 23464712 |
| Chronic heart failure | Stem Cell Exhaustion | Expression of miR-126 and miR-508-5p in endothelial progenitor cells is associated with the prognosis of chronic heart failure patients. | 23465244 |
| physiopathological, Coronary Arteriosclerosis | Stem Cell Exhaustion | MicroRNA (miRNA) expression profiles in endothelial progenitor cells (EPCs) contribute to EPC dysfunction in patients suffering from coronary artery disease. | 23465244 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Donor cell leukemia (DCL) is a rare but severe complication after allogeneic stem cell transplantation. | 23465275 |
| Triple-Negative Breast Cancer Finding, Specialty Type - cancer | Stem Cell Exhaustion | In models of triple-negative breast cancer (TNBC), it has recently been shown that the epidermal growth factor receptor (EGFR) pathway is up-regulated in the aldehyde dehydrogenase 1 (ALDH1)-positive cancer stem cell fraction. | 23465277 |
| Brain Injuries | Stem Cell Exhaustion | Ischemic brain injury: a consortium analysis of key factors involved in mesenchymal stem cell-mediated inflammatory reduction. | 23466243 |
| PAFAH1B1 wt Allele, Bone Marrow Diseases, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Myelodysplastic syndrome (MDS) is a group of progressive,clonal, neoplastic bone marrow disorders characterized by hematopoietic stem cell dysregulation and abnormalities in the immune system. | 23469196 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | The different immunoregulatory functions on dendritic cells between mesenchymal stem cells derived from bone marrow of patients with low-risk or high-risk myelodysplastic syndromes. | 23469196 |
| Myopathy | Stem Cell Exhaustion | Because the symptoms of myopathy gradually improved and disappeared completely, the patient was able to undergo one course of intensive chemotherapy and allogeneic stem cell transplantation from an HLA-matched sibling donor, 8 months after admission (7 months after the re-administration of IM). | 23470829 |
| Leukemia, Myelocytic, Acute, Decreased platelet count | Stem Cell Exhaustion | [Emergence of donor-derived anti-HLA antibody and subsequent transfusion-refractory thrombocytopenia after allogeneic hematopoietic stem cell transplantation from an HLA-matched sibling donor in a patient with acute myeloid leukemia]. | 23470830 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | A 45-year-old woman with acute myelogenous leukemia developed platelet transfusion refractoriness (PTR) after the engraftment of an allogeneic peripheral blood stem cell transplantation (PBSCT) from her multiparous sister, which was attributed to HLA antibodies that could not be detected in the patient's serum before transplantation. | 23470830 |
| Ischemia | Stem Cell Exhaustion | Attenuation of hind-limb ischemia in mice with endothelial-like cells derived from different sources of human stem cells. | 23472116 |
| Ischemia | Stem Cell Exhaustion | We differentiated functional EC from human bone marrow mononuclear cells (BM-EC), human embryonic stem cells (hESC-EC) and human induced pluripotent stem cells (hiPSC-EC), and compared their in-vitro tube formation, migration and cytokine expression profiles, and in-vivo capacity to attenuate hind-limb ischemia in mice. | 23472116 |
| Aggressive Adult Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Only one-quarter to one-third of patients with relapsed/refractory aggressive non-Hodgkin lymphoma (r/r-aNHL) treated with common salvage chemotherapy regimens and autologous stem cell transplant (ASCT) achieve 5-year progression-free survival (PFS). | 23472969 |
| leukemia, Leukemia, Myelocytic, Acute, Immature Myeloid Cell | Stem Cell Exhaustion | Clustered immature myeloid precursors in intertrabecular region during remission evolve from leukemia stem cell near endosteum and contribute to disease relapse in acute myeloid leukemia. | 23474071 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Most acute myeloid leukemia (AML) cannot be cured because leukemia stem cells (LSC) will contribute to eventual relapse. | 23474071 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Long-term follow up of patients proceeding to transplant using plerixafor mobilized stem cells and incidence of secondary myelodysplastic syndrome/AML. | 23474805 |
| Leukemia, T-Cell | Stem Cell Exhaustion | Potential contribution of a novel Tax epitope-specific CD4+ T cells to graft-versus-Tax effect in adult T cell leukemia patients after allogeneic hematopoietic stem cell transplantation. | 23475215 |
| TCL4 gene, TRPV6 wt Allele | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for adult T cell leukemia/lymphoma (ATL) caused by human T cell leukemia virus type 1 (HTLV-1). | 23475215 |
| Specialty Type - cancer | Stem Cell Exhaustion | Previous reports suggest that a CD133-positive subpopulation of multipotent cells with extensive proliferative and self-renewal characteristics has biological features of a cancer stem cell. | 23479121 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Selective killing of candidate AML stem cells by antibody targeting of IL1RAP. | 23479569 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | IL1RAP, a co-receptor for interleukin (IL)-1 and IL-33 receptors, was previously found to be highly upregulated on candidate chronic myeloid leukemia stem cells, allowing for leukemia-selective killing using IL1RAP-targeting antibodies. | 23479569 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | With the aim to target AML stem cells, an anti-IL1RAP monoclonal antibody was generated followed by isotype switching for improved antibody-dependent, cell-mediated cytotoxicity activity. | 23479569 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Minor histocompatibility antigens as determinants for graft-versus-host disease after allogeneic haematopoietic stem cell transplantation. | 23480177 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Acute myeloid leukemia (AML) is a deadly disease characterized by the clonal expansion and accumulation of hematopoietic stem cells arrested at various stages of development. | 23481040 |
| Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | Lack of prognostic significance of neuroendocrine differentiation and stem cell antigen co-expression in resected early-stage non-small cell lung cancer. | 23482770 |
| Carcinoid Tumor, Carcinoma of lung | Stem Cell Exhaustion | Neuroendocrine (NE) carcinomas of the lung exhibit expression of various stem cell antigens, and except for carcinoid tumours, carry a poor prognosis. | 23482770 |
| Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | Despite the fact that 10%-30% of all non-small cell lung carcinomas (NSCLC) which are not classified as NE carcinomas also show expression of NE markers, data on their prognostic significance are conflicting and analyses of the expression and relevance of stem cell antigens in this subgroup are lacking. | 23482770 |
| Non-Small Cell Lung Carcinoma, Childhood Breast Carcinoma | Stem Cell Exhaustion | Moreover, the subgroup of NSCLC with NE differentiation (ND) were assessed for the expression and prognostic significance of the stem cell antigens CD117, CD133 and breast cancer resistance protein-1 (ABCG2). | 23482770 |
| Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | This study indicates that neither ND, nor co-expression of the stem cell antigens CD117, CD133 or ABCG2, have a prognostic significance in resected early-stage NSCLC. | 23482770 |
| Multiple Myeloma | Stem Cell Exhaustion | Autologous/reduced-intensity allogeneic stem cell transplantation vs autologous transplantation in multiple myeloma: long-term results of the EBMT-NMAM2000 study. | 23482933 |
| Leukemia, Mast-Cell, Mastocytosis, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | A case of systemic mastocytosis associated with acute myeloid leukemia terminating as aleukemic mast cell leukemia after allogeneic hematopoietic stem cell transplantation. | 23483057 |
| Leukemia, Mast-Cell, Aplastic Anemia | Stem Cell Exhaustion | After allogeneic hematopoietic stem cell transplantation (HSCT), leukemic myeloblasts were not observed; however, neoplastic metachromatic blasts strikingly proliferated during the state of bone marrow aplasia, and finally, aleukemic mast cell leukemia developed. | 23483057 |
| Encephalomyelitis | Stem Cell Exhaustion | We describe a rare case of fatal mumps encephalomyelitis occurring in 19-year old male following matched unrelated donor peripheral blood haematopoietic stem cell transplantation (HSCT). | 23485346 |
| Non-Neoplastic Hematologic and Lymphocytic Disorder | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation is the only potentially curative therapeutic option for many malignant and nonmalignant hematologic disorders. | 23491865 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | The patient, presenting an high risk myelodysplastic syndrome (MDS), underwent an allogeneic peripheral stem cells transplantation. | 23491865 |
| Nerve Degeneration | Stem Cell Exhaustion | let-7 miRNAs regulate stem cell differentiation and T cell activation, activate Toll-like receptor 7, and are linked to neurodegeneration. | 23494648 |
| Hematologic Neoplasms | Stem Cell Exhaustion | The use of allogeneic haematopoietic stem cell transplantation (Allo-HSCT) is a standard treatment option for many patients with haematological malignancies. | 23496350 |
| Hepatitis B | Stem Cell Exhaustion | The more profound immunosuppression in recipients of hematopoietic stem cell transplantations (HCT) can lead to more complicated hepatitis B virus (HBV)-related events. | 23498831 |
| Hepatitis B | Stem Cell Exhaustion | However the donor had hepatitis B surface antigen (HbsAg) positivity, and collected stem cells were positive for HBV DNA (1 x 10(4) copies/mL). | 23498831 |
| Specialty Type - cancer, Cytogenetic Complete Response | Stem Cell Exhaustion | In CRC specimens, expression of CD133, a cancer stem cell marker, was significantly correlated with gankyrin expression. | 23508981 |
| Cytogenetic Complete Response | Stem Cell Exhaustion | In CRC development, gankyrin would control stem cell behavior by regulating the expression of stemness factors. | 23508981 |
| Crushing injury | Stem Cell Exhaustion | They also differentiated into all three germ layer lineages both in vitro and in vivo, produced cartilage more efficiently compared to bone marrow stem cells and, importantly, restored erectile function in a cavernous nerve crush injury rat model. | 23509942 |
| Multiple Myeloma | Stem Cell Exhaustion | Comparable outcome of stem cell transplant versus bortezomib-based consolidation in myeloma patients after major response to induction. | 23510553 |
| Multiple Myeloma | Stem Cell Exhaustion | High-dose therapy with autologous stem cell transplant (ASCT) has been established as standard treatment for eligible patients with myeloma. | 23510553 |
| Leishmania donovani | Stem Cell Exhaustion | Stem cell transplant was planned due to repeated reactivations of disease, but his pretransplant bone marrow revealed an unexpected protozoan-Leishmania donovani. | 23511497 |
| Cessation of life | Stem Cell Exhaustion | Increase of suicide and accidental death after hematopoietic stem cell transplantation: a cohort study on behalf of the Late Effects Working Party of the European Group for Blood and Marrow Transplantation (EBMT). | 23512286 |
| Encephalitis, Allogeneic Hematopoietic Stem Cell Transplantation, Herpes | Stem Cell Exhaustion | Human herpes 6 virus encephalitis complicating allogeneic hematopoietic stem cell transplantation. | 23516318 |
| Encephalitis | Stem Cell Exhaustion | To describe the presentation and management of encephalitis due to human herpes 6 virus (HHV-6) in patients who underwent allogeneic hematopoietic stem cell transplant (alloHSCT), via retrospective chart review. | 23516318 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance. | 23519090 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal hematopoietic stem cell diseases. | 23519573 |
| Pulmonary Emphysema | Stem Cell Exhaustion | Due to his severe emphysema, the patient was considered ineligible for stem cell transplantation, and azacitidine therapy was initiated. | 23519573 |
| Hematological Disease | Stem Cell Exhaustion | Comparison of outcomes after two standards-of-care reduced-intensity conditioning regimens and two different graft sources for allogeneic stem cell transplantation in adults with hematologic diseases: a single-center analysis. | 23523970 |
| Toxic effect | Stem Cell Exhaustion | Recent advances in allogeneic stem cell transplantation (allo-HSCT) have included the advent of reduced-intensity conditioning (RIC) regimens to decrease the toxicity of myeloablative allo-SCT and the use of double umbilical cord blood (dUCB) units as a graft source in adults lacking a suitable donor. | 23523970 |
| Allogeneic Hematopoietic Stem Cell Transplantation, Acute GVH disease | Stem Cell Exhaustion | Salivary proteomic analysis and acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. | 23529013 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease (GVHD) is the major life-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT), developing in 35%-70% of all allo-HSCT recipients despite immunosuppressive prophylaxis. | 23529013 |
| Lymphoma, Non-Hodgkin | Stem Cell Exhaustion | CD20-targeted T cells after stem cell transplantation for high risk and refractory non-Hodgkin's lymphoma. | 23529012 |
| melanoma | Stem Cell Exhaustion | In vitro expansion and characterization of corneal stem cells isolated from an eye with malignant melanoma. | 23529306 |
| Malignant Neoplasms | Stem Cell Exhaustion | Donor age (72 years) and the presence of a malignant tumor close to limbal stem niche could have had an impact on the proliferation rate and the characteristics of the corneal stem cells. | 23529306 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Impact of pre-transplant marrow blasts on survival of allogeneic stem cell transplantation in adult acute myeloid leukemia. | 23529846 |
| Mumps | Stem Cell Exhaustion | A five-year-old Canadian-born boy with a history of a hematopoetic stem cell transplant three years previously received live attenuated measles, mumps, and rubella (MMR) vaccine. | 23531102 |
| Neoplasms | Stem Cell Exhaustion | Autologous stem cell transplantation and cyberknife therapy resulted in mixed tumor response, with incidental note made of prominent areas of cortical FDG avidity in the right kidney. | 23531731 |
| Aggressive Non-Hodgkin Lymphoma, Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | High-dose chemotherapy (HDT) followed by autologous stem cell transplantation (ASCT) is considered standard in the treatment of patients with relapsed or refractory aggressive peripheral T cell lymphoma (PTCL). | 23532626 |
| Glioblastoma Multiforme Pathway, Adult Glioblastoma, Neoplasms | Stem Cell Exhaustion | Stem cell-like properties of glioma initiating cells (GiCs) fuel glioblastoma (GBM) development by providing the different cell types that comprise the tumor. | 23533157 |
| Multiple Myeloma | Stem Cell Exhaustion | Living with advanced but stable multiple myeloma: a study of the symptom burden and cumulative effects of disease and intensive (hematopoietic stem cell transplant-based) treatment on health-related quality of life. | 23535325 |
| Experimental Organism Basal Cell Carcinoma, Malignant Neoplasms | Stem Cell Exhaustion | The basal cell carcinoma is a malignant tumor which originates from the epidermal stem cells. | 23535947 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | Stem cell-like gene expression in ovarian cancer predicts type II subtype and prognosis. | 23536770 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | The purpose of this study was the genomic identification and characterization of a subtype of ovarian cancer that has stem cell-like gene expression. | 23536770 |
| Malignant neoplasm of ovary, Neoplasms | Stem Cell Exhaustion | The stem cell-like signature was prognostic within high-stage serous ovarian cancer, classifying a small subset of high-stage tumors with better prognosis, in the differentiated subtype. | 23536770 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cells are believed to have properties that allow them to survive therapy and may drive recurrent tumor growth. | 23536770 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells or cancer-initiating cells are a rare cell population and difficult to isolate experimentally. | 23536770 |
| Malignant neoplasm of ovary, Neoplasms | Stem Cell Exhaustion | Genes that are expressed by stem cells may characterize a subset of less differentiated tumors and aid in prognostic classification of ovarian cancer. | 23536770 |
| Specialty Type - cancer, ovarian neoplasm | Stem Cell Exhaustion | Using human and mouse gene signatures of embryonic, adult, or cancer stem cells, we performed an unsupervised bipartition class discovery on expression profiles from 145 serous ovarian tumors to identify a stem-like and more differentiated subgroup. | 23536770 |
| Specialty Type - cancer | Stem Cell Exhaustion | Patients (N = 627) in stem cell transplant (SCT) and medical (MED) or radiation (RAD) oncology at two comprehensive cancer centers, enrolled in the Electronic Self-Report Assessment-Cancer study and completed the QLQ-C30 at T1 and T2. | 23537330 |
| Specialty Type - cancer, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Cancer stem cells (CSCs) are notorious for their capacity of tumor progression, metastasis or resistance to chemo-radiotherapy. | 23537343 |
| Glioblastoma | Stem Cell Exhaustion | Neural progenitor cells in the subventricular zone (SVZ) have a controversial role in glioblastoma multiforme (GBM) as potential tumor-initiating cells. | 23540348 |
| Primary immune deficiency disorder | Stem Cell Exhaustion | Pathway and network analysis of the differentially expressed proteins by Ingenuity Pathway Analysis revealed vital canonical pathways involving acute phase response signaling, the complement system, LXR/RXR activation, hematopoiesis from pluripotent stem cells, and primary immunodeficiency signaling. | 23541716 |
| FLT3 Internal Tandem Duplication, Nephroblastoma, Leukemia, Myelocytic, Acute, Cytogenetically normal acute myeloid leukemia | Stem Cell Exhaustion | Using real-time quantitative PCR, we monitored Wilms tumor gene 1 (WT1) expression from diagnosis to hematopoietic stem cell transplantation (HSCT) in adult patients with cytogenetically normal acute myelogenous leukemia (CN-AML) and FLT3-ITD and NPM1 mutations. | 23542687 |
| Malignant tumor of colon | Stem Cell Exhaustion | Prognostic value of changes in the expression of stem cell markers in the peripheral blood of patients with colon cancer. | 23545848 |
| Colorectal Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Samples of EDTA blood were collected from metastatic colorectal cancer patients, and circulating cancer stem cells were isolated for the analysis of the expression of stem cell markers using RT-PCR. | 23545848 |
| Specialty Type - cancer, Secondary Neoplasm, Carcinogenesis | Stem Cell Exhaustion | Cancer stem cells play an important role in carcinogenesis and resistance to treatment and may lead to metastasis. | 23545848 |
| Prostate carcinoma | Stem Cell Exhaustion | Hypoxia of PC-3 prostate cancer cells enhances migration and vasculogenesis in vitro of bone marrow-derived endothelial progenitor cells by secretion of cytokines. | 23546641 |
| Lymphoma, Follicular | Stem Cell Exhaustion | The objective of this randomized trial was to assess the efficacy and safety of rituximab as in vivo purging before transplantation and as maintenance treatment immediately after high-dose chemotherapy and autologous stem-cell transplantation (HDC-ASCT) in patients with relapsed follicular lymphoma (FL). | 23547078 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Dasatinib maintenance therapy after allogeneic hematopoietic stem cell transplantation for an isolated central nervous system blast crisis in chronic myelogenous leukemia. | 23548721 |
| Anemia, Leukocytosis | Stem Cell Exhaustion | Although offered to her because of severe anemia and leukocytosis, the patient did not consent to allogeneic hematopoietic stem cell transplantation. | 23548970 |
| Specialty Type - cancer | Stem Cell Exhaustion | The restricted cataloging of cancer genomes is quite unlikely to achieve the task of curing cancer, unless it is integrated into metabolic networks that respond to and influence the constantly evolving cancer stem cell (CSC) cellular states. | 23549172 |
| Specialty Type - cancer | Stem Cell Exhaustion | The Warburg effect version 2.0: metabolic reprogramming of cancer stem cells. | 23549172 |
| Bronchiolitis Obliterans, Allogeneic Hematopoietic Stem Cell Transplantation | Stem Cell Exhaustion | A case-control study of bronchiolitis obliterans syndrome following allogeneic hematopoietic stem cell transplantation. | 23551210 |
| Bronchiolitis Obliterans, Bosnian language | Stem Cell Exhaustion | Bronchiolitis obliterans syndrome (BOS) is a significant complication after allogeneic hematopoietic stem cell transplantation (HSCT). | 23551210 |
| Extrapulmonary Small Cell Carcinoma, Squamous cell carcinoma of esophagus, Adenocarcinoma Of Esophagus | Stem Cell Exhaustion | Five potential new molecular targets in esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC) were investigated for their expression characteristics: vascular endothelial growth factor receptor (VEGFR)-3, human epidermal growth factor receptor-2, stem cell growth factor receptor, tissue inhibitors of metalloproteinase (TIMP)-4 and TIMP-3. | 23551625 |
| Extrapulmonary Small Cell Carcinoma, Neoplasms | Stem Cell Exhaustion | For TIMP-4, TIMP-3 and stem cell growth factor receptor, trends to higher expression in tumor tissue were also found in EAC and ESCC that had received neoadjuvant treatment. | 23551625 |
| Metapneumovirus | Stem Cell Exhaustion | Fatal human metapneumovirus infection following allogeneic hematopoietic stem cell transplantation. | 23551689 |
| Communicable Diseases, Chronic graft-versus-host disease, Respiratory Tract Diseases, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Here, we report the occurrence of fatal lower respiratory tract disease associated with human metapneumovirus (HMPV) infection in a 10-year-old girl with chronic graft-versus-host disease following allogeneic hematopoietic stem cell transplantation (HSCT) for secondary chronic myeloid leukemia. | 23551689 |
| Conjunctival scar | Stem Cell Exhaustion | Forty eyes of 39 patients with severe limbal stem cell deficiency and conjunctival scarring or symblepharon underwent transplantation of autologous cocultivated epithelium on human amniotic membrane. | 23552358 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Abnormal proliferation and differentiation of hematopoietic stem/progenitor cells, which reflect the malignant nature of clonal cells in myelodysplastic syndromes (MDS), can be detected by flow cytometry (FCM) and potentially applied to assist diagnosis and evaluate prognosis in MDS. | 23554290 |
| Microvascular Angina | Stem Cell Exhaustion | Effect of exercise on circulating endothelial progenitor cells in microvascular angina. | 23558828 |
| Microvascular Angina, Endothelial dysfunction, doxorubicin/mitomycin/vinblastine protocol | Stem Cell Exhaustion | Circulating endothelial progenitor cells (EPCs) might limit endothelial dysfunction in patients with microvascular angina (MVA). | 23558828 |
| Communicable Diseases | Stem Cell Exhaustion | We have used humanized mice, in which human immune cells differentiate de novo from transplanted cord blood progenitor cells, to study the human immune responses to infection with Mycobacterium bovis bacillus Calmette-Guerin and Mycobacterium tuberculosis. | 23559373 |
| Cell Proliferation | Stem Cell Exhaustion | We previously reported that importin 13 (IPO13), a member of the importin-b family of nuclear import proteins, regulates nuclear import of the glucocorticoid receptor in airway epithelial cells, IPO13 serves as a potential marker for corneal epithelial progenitor cells, and IPO13 is associated with corneal cell proliferation. | 23559854 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | The objective of this study was to assess the effect of high-dose atorvastatin treatment on endothelial progenitor cell (EPC) recruitment and angiographic and clinical outcome in coronary artery disease (CAD) patients treated with the Genous EPC-capturing stent. | 23561893 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Efficacy and safety of autologous bone marrow-derived stem cell transplantation in patients with type 2 diabetes mellitus: a randomized placebo-controlled study. | 23561959 |
| Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Busulfan dose intensity and outcomes in reduced-intensity allogeneic peripheral blood stem cell transplantation for myelodysplastic syndrome or acute myeloid leukemia. | 23562738 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | busulfan dosing (total dose 3.2 mg/kg versus 6.4 mg/kg) in RIC regimens that combined fludarabine and busulfan on outcomes in patients who were undergoing hematopoietic stem cell transplantation (HSCT) for myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). | 23562738 |
| Peripheral Stem Cell Transplantation, PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | A total of 217 consecutive patients with MDS or AML underwent first busulfan and fludarabine RIC peripheral blood stem cell transplantation from well-matched related or unrelated donors at our institutions between 2004 and 2009. | 23562738 |
| Peripheral Stem Cell Transplantation, PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | For the majority of patients with MDS or AML undergoing busulfan and fludarabine RIC peripheral blood stem cell transplantation, however, the dose of busulfan (3.2 mg/kg versus 6.4 mg/kg) is not associated with significant differences in overall outcomes. | 23562738 |
| Specialty Type - cancer, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Stem Cell Exhaustion | SDF-1-CXCR4 axis: cell trafficking in the cancer stem cell niche of head and neck squamous cell carcinoma. | 23563306 |
| Specialty Type - cancer | Stem Cell Exhaustion | The SDF-1-CXCR4 axis is postulated to be a crucial key pathway in the interaction between (cancer) stem cells and their surrounding supportive cells in the cancer stem cell niche. | 23563306 |
| Specialty Type - cancer | Stem Cell Exhaustion | We evaluated the expression of CD44 as a cancer stem cell marker and of CXCR4 in human HNSCC tissue samples. | 23563306 |
| Neoplasms | Stem Cell Exhaustion | We showed that CD44, as a stem cell marker in HNSCC, is located mainly at the borderline of HNSCC tumor nests with the surrounding cells. | 23563306 |
| Specialty Type - cancer | Stem Cell Exhaustion | We collected evidence that SDF-1-CXCR4 interaction may be a crucial pathway in cell trafficking in the cancer stem cell niche of HNSCC, while SDF-1 was not detected in the peripheral blood of HNSCC patients. | 23563306 |
| Specialty Type - cancer | Stem Cell Exhaustion | The SDF-1-CXCR4 axis may play an important role in the cancer stem cell theory of HNSCC. | 23563306 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Granulocyte-colony stimulating factors (G-CSFs) enhance bone marrow (BM) recovery after autologous stem cell transplant (ASCT) in patients with lymphoma and myeloma. | 23566160 |
| Toxic effect | Stem Cell Exhaustion | This stem cell therapy results in significant global correction of the metabolic profile that characterizes the disease, both in the periphery and the central nervous system, the target organ for toxicity in iMSUD. | 23566440 |
| Osteosclerosis, Fibrosis Assessment, Primary Myelofibrosis | Stem Cell Exhaustion | Primary myelofibrosis (PM) is a Philadelphia-negative clonal hematopoietic stem cell disorder characterized by intense reactive changes of bone marrow stroma with collagen fibrosis, osteosclerosis and angiogenesis. | 23568162 |
| Hypoxia | Stem Cell Exhaustion | Passage-dependent cancerous transformation of human mesenchymal stem cells under carcinogenic hypoxia. | 23568779 |
| Specialty Type - cancer | Stem Cell Exhaustion | Bone marrow-derived human mesenchymal stem cells (hMSCs) either promote or inhibit cancer progression, depending on factors that heretofore have been undefined. | 23568779 |
| Colorectal Carcinoma, Cytogenetic Complete Response | Stem Cell Exhaustion | Olfactomedin 4 is a useful marker for stem cells in the intestine and is an independent prognostic molecule for survival in patients with colorectal cancer (CRC). | 23570326 |
| Colorectal Carcinoma, Malignant tumor of colon | Stem Cell Exhaustion | Prognostic role of p53 messenger ribonucleic acid expression in patients after curative resection for stage I to III colorectal cancer: association with colon cancer stem cell markers. | 23571142 |
| Infection of bloodstream | Stem Cell Exhaustion | Comparison of characteristics of bacterial bloodstream infection between adult patients with allogeneic and autologous hematopoietic stem cell transplantation. | 23571460 |
| Infection of bloodstream | Stem Cell Exhaustion | Although autologous and allogeneic hematopoietic stem cell transplantation (HSCT) are fundamentally different procedures, a tailored approach to bacterial bloodstream infection (BSI) according to the type of HSCT has not yet been suggested. | 23571460 |
| Respiratory Syncytial Virus Infections | Stem Cell Exhaustion | Impact of aerosolized ribavirin on mortality in 280 allogeneic haematopoietic stem cell transplant recipients with respiratory syncytial virus infections. | 23572228 |
| Infection | Stem Cell Exhaustion | Respiratory syncytial virus (RSV) infections are well recognized as a significant cause of morbidity and mortality in allogeneic haematopoietic stem cell transplant (allo-HSCT) recipients. | 23572228 |
| Experimental Organism Malignant Hepatocholangiocellular Carcinoma, Ductal plate malformation | Stem Cell Exhaustion | Combined hepatocellular-cholangiocarcinoma with stem cell features, ductal plate malformation subtype: a case report and proposal of a new subtype. | 23573322 |
| Experimental Organism Malignant Hepatocholangiocellular Carcinoma | Stem Cell Exhaustion | In the current WHO blue book, combined hepatocellular-cholangiocarcinoma (C-HCC-CC) was classified into two types; classical type and type with stem cell features. | 23573322 |
| Neoplasms | Stem Cell Exhaustion | The author herein proposes that this tumor should be included or added in the C-HCC-CC subtype as C-HCC-CC with stem cell features, DMP subtype. | 23573322 |
| Age related macular degeneration | Stem Cell Exhaustion | To evaluate endothelial progenitor cell [late outgrowth endothelial progenitor cells (OECs)], vascular endothelial growth factor (VEGF), and stromal cell-derived factor 1a (SDF-1a) plasma levels as potential biomarkers before and during ranibizumab (Lucentis((r))) treatment for neovascular age-related macular degeneration (nvAMD). | 23573802 |
| Multiple Myeloma | Stem Cell Exhaustion | This phase I/II study was conducted to evaluate the safety and efficacy of bortezomib-melphalan-prednisolone in Japanese patients with previously untreated multiple myeloma who are ineligible for hematopoietic stem cell transplantation. | 23574271 |
| Specialty Type - cancer | Stem Cell Exhaustion | Thus, oxidative mitochondrial metabolism (OXPHOS) is a common feature of both (1) normal stem cells and (2) proliferating cancer cells. | 23574725 |
| Angina Pectoris | Stem Cell Exhaustion | Endothelial progenitor cells predict long-term prognosis in patients with stable angina treated with percutaneous coronary intervention: five-year follow-up of the PROCREATION study. | 23575363 |
| Fracture | Stem Cell Exhaustion | Primary PCI with endothelial progenitor cell-capture stent in patient with skull base fracture and aspirin allergy. | 23575723 |
| Multiple Myeloma | Stem Cell Exhaustion | Therapeutic options for patients with recurrent multiple myeloma after autologous stem cell transplantation (ASCT) include novel agents, conventional chemotherapy, or salvage ASCT with no standard of care. | 23576287 |
| Multiple Myeloma | Stem Cell Exhaustion | A retrospective review was carried out of the records of patients with multiple myeloma who underwent melphalan-based autologous stem cell transplantation (MEL-ASCT) and developed B19 infection (January 2009-December 2011). | 23578205 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Adult acute myeloid leukemia (AML) is a highly heterogeneous stem cell malignancy characterized by the clonal expansion of immature myeloid precursors. | 23579575 |
| Lymphopenia | Stem Cell Exhaustion | Successful fludarabine-based hematopoietic stem cell transplantation in a pediatric patient with idiopathic CD4+ lymphocytopenia. | 23581828 |
| Heart failure | Stem Cell Exhaustion | Cardiopoietic stem cell therapy in heart failure: the C-CURE (Cardiopoietic stem Cell therapy in heart failURE) multicenter randomized trial with lineage-specified biologics. | 23583246 |
| Chronic heart failure | Stem Cell Exhaustion | This study sought to evaluate the feasibility and safety of autologous bone marrow-derived and cardiogenically oriented mesenchymal stem cell therapy and to probe for signs of efficacy in patients with chronic heart failure. | 23583246 |
| Heart failure | Stem Cell Exhaustion | In pre-clinical heart failure models, cardiopoietic stem cell therapy improves left ventricular function and blunts pathological remodeling. | 23583246 |
| Heart failure | Stem Cell Exhaustion | The C-CURE (Cardiopoietic stem Cell therapy in heart failURE) trial, a prospective, multicenter, randomized trial, was conducted in patients with heart failure of ischemic origin who received standard of care or standard of care plus lineage-specified stem cells. | 23583246 |
| Chronic heart failure | Stem Cell Exhaustion | Cardiopoietic stem cell therapy was found feasible and safe with signs of benefit in chronic heart failure, meriting definitive clinical evaluation. | 23583246 |
| Shock, Cardiogenic | Stem Cell Exhaustion | In the cell therapy arm, bone marrow was harvested and isolated mesenchymal stem cells were exposed to a cardiogenic cocktail. | 23583246 |
| Acute leukemia | Stem Cell Exhaustion | In this randomized, controlled study, 90 patients with recently diagnosed acute leukemia (n = 36) or patients with malignant hemopathies undergoing autologous hematopoietic stem cell transplantation (HSCT) (n = 54) and without LVSD were randomly assigned to a group receiving enalapril and carvedilol (n = 45) or to a control group (n = 45). | 23583763 |
| herpesvirus 3, human | Stem Cell Exhaustion | Varicella-zoster virus (VZV) reactivation is a frequent complication after allogeneic hematopoietic stem cell transplantation (HSCT). | 23583826 |
| Pure Red-Cell Aplasia | Stem Cell Exhaustion | No standard of care for pure red cell aplasia (PRCA) after major ABO-incompatible hematopoietic stem cell transplantation (HSCT) has been established. | 23583828 |
| Specialty Type - cancer | Stem Cell Exhaustion | The aim of our study is to evaluate the surface glycoprotein CD133 as marker of cancer stem cells, as independent prognostic pattern of survival and its positive expression ratio to a chemotherapy increased resistance. | 23584268 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Studies comparing the efficacy and cost of stem cell mobilization with intermediate-dose CY (ID-CY) and G-CSF against plerixafor and G-CSF, specifically in multiple myeloma (MM) patients treated in the novel therapy era, are not available. | 23584435 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Aldehyde dehydrogenase 1A1 (ALDH1A1) has been characterized as a cancer stem cell marker in different types of tumors. | 23585015 |
| Subcapsular Renal Hematoma | Stem Cell Exhaustion | Spontaneous subcapsular splenic hematoma associated with filgrastim in a patient undergoing allogeneic hematopoietic stem cell transplantation. | 23585644 |
| Subcapsular Renal Hematoma | Stem Cell Exhaustion | To report the development of a spontaneous subcapsular splenic hematoma following filgrastim administration in a patient undergoing an allogeneic hematopoietic stem cell transplant. | 23585644 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | A 60-year-old female with myelodysplastic syndrome was admitted for a reduced-intensity allogeneic hematopoietic stem cell transplant from an unrelated donor. | 23585644 |
| Splenic Rupture, filgrastim | Stem Cell Exhaustion | Although splenic rupture attributed to filgrastim in a patient undergoing allogeneic hematopoietic stem cell transplantation has been reported, to our knowledge, this is the first case report to establish causality. | 23585644 |
| Splenic Rupture, Splenic hematoma | Stem Cell Exhaustion | Filgrastim has been associated with splenic hematoma and splenic rupture, predominantly in healthy donors undergoing mobilization of peripheral blood stem cells. | 23585644 |
| Specialty Type - cancer | Stem Cell Exhaustion | Pathway analysis supported that the miRNAs may regulate signaling associated with induction and maintenance of cancer and stem cell, such as p53, ErbB1, Notch, Wnt, and TGF-b signaling pathways. | 23586679 |
| Cessation of life | Stem Cell Exhaustion | Bioinformatic analysis revealed that the differentially expressed miRNAs and their putative target genes were mainly involved in cell death, cellular development, and cellular growth and proliferation, which are the key regulators for stem cells. | 23586679 |
| Infection | Stem Cell Exhaustion | Prognostic impact of pretransplant iron overload measured with magnetic resonance imaging on severe infections in allogeneic stem cell transplantation. | 23586843 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | In the liver of patients with non-recurrence, expression of PDGFC and other angiogenesis genes, cancer stem cell marker genes, and genes related to tumor progression was down-regulated, while expression of genes related to hepatocyte differentiation, tumor suppression genes, and other genes related to apoptosis induction was up-regulated. | 23587162 |
| Ki-1+ Anaplastic Large Cell Lymphoma | Stem Cell Exhaustion | We present a pediatric patient with ALCL who experienced second relapse after standard chemotherapy and autologous and allogeneic hematopoietic stem cell transplantation. | 23588340 |
| JAG1 wt Allele | Stem Cell Exhaustion | These AGS effects were shown to be mediated by telomerase since they were not observed when TERT was depleted from hMSC or in mouse embryonic stem cells derived from TERT knockout mice. | 23590815 |
| Multiple Myeloma | Stem Cell Exhaustion | Evaluating the effects of lenalidomide induction therapy on peripheral stem cells collection in patients undergoing autologous stem cell transplant for multiple myeloma. | 23591714 |
| Failure | Stem Cell Exhaustion | Prior LEN therapy is associated with an increased risk of peripheral blood stem cell collection (PBSC) failure, particularly with filgrastim (G-CSF) alone. | 23591714 |
| Carcinoma of bladder, Carcinoma | Stem Cell Exhaustion | Oct-4 as a stem cell marker is expressed in carcinoma cells and in stromal cells of bladder carcinoma, where they may cooperate in the progression of bladder carcinoma by acquiring aggressive features, such as a liability for recurrence and dissemination. | 23594289 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Most tumors contain a minor population of cancer stem cells that are responsible for tumor heterogeneity, resistance to therapy and recurrence. | 23594289 |
| Ischemic, Acute Coronary Syndrome | Stem Cell Exhaustion | Circulating platelet-progenitor cell coaggregate formation is increased in patients with acute coronary syndromes and augments recruitment of CD34+ cells in the ischaemic microcirculation. | 23594593 |
| GDC AJCC Clinical Stage Terminology, Acute myocardial infarction | Stem Cell Exhaustion | These findings imply that circulating platelet/CD34+ cell coaggregate levels are increased in ACS, especially in STEMI, which may be a novel mechanism of domiciliation of CD34+ progenitor cells to the injured microvasculature after acute myocardial infarction. | 23594593 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Leukemia stem cells (LSCs) that survive conventional chemotherapy are thought to contribute to disease relapse, leading to poor long-term outcomes for patients with acute myeloid leukemia (AML). | 23596204 |
| HCK gene | Stem Cell Exhaustion | We previously identified a Src-family kinase (SFK) member, hematopoietic cell kinase (HCK), as a molecular target that is highly differentially expressed in human primary LSCs compared with human normal hematopoietic stem cells (HSCs). | 23596204 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Effect of intensive glycaemic control on endothelial progenitor cells in patients with long-standing uncontrolled type 2 diabetes. | 23598596 |
| Vascular System Injuries | Stem Cell Exhaustion | Endothelial progenitor cells (EPCs) have an important role in repair following vascular injury. | 23598596 |
| Neoplasms | Stem Cell Exhaustion | Sex determining region Y-box 2 (SOX2), is a high mobility group box transcription factor involved in the maintenance of pluripotency and the self-renewal of embryonic and neuronal stem cells, which also plays differential roles in the cell proliferation of several tumors. | 23599173 |
| X-linked inheritance, Ancestor | Stem Cell Exhaustion | The patients with X-linked dystonia-parkinsonism also showed a lack of neuropeptide Y labelling in the subventricular zone, where a marked loss of progenitor cells that express proliferating cell nuclear antigen was found. | 23599389 |
| Adenoma | Stem Cell Exhaustion | CD24 and CD44 in salivary gland pleomorphic adenoma and in human salivary gland morphogenesis: differential markers of glandular structure or stem cell indicators? | 23600676 |
| Mixed Salivary Gland Tumor, Salivary Gland Neoplasms | Stem Cell Exhaustion | Pleomorphic adenoma (PA) is a benign salivary gland neoplasm that comprises epithelial and myoepithelial cells and a complex stroma, whose structure, architecture and origin (from intercalated ducts) suggest stem cell participation. | 23600676 |
| Specialty Type - cancer | Stem Cell Exhaustion | We compared the expression of CD24 and CD44 in PA and in developing human salivary glands to investigate whether these markers can be considered as cancer stem cell markers. | 23600676 |
| Neoplasms | Stem Cell Exhaustion | PA and stem cells share the expression of CD24 and CD44; their value as markers of neoplastic cell multipotency and the implications of their expression for tumour behaviour are yet to be determined. | 23600676 |
| Specialty Type - cancer | Stem Cell Exhaustion | OCT4 is the key gene that controls the automatic renewal of stem cells, and regulates the proliferation and differentiation of cancer stem cells. | 23601300 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Impact of ocular graft-versus-host disease on visual quality of life in patients after allogeneic stem cell transplantation: questionnaire study. | 23601505 |
| Complication Aspects | Stem Cell Exhaustion | To determine the influence of ocular complications on quality of life (QoL) 3 years after allogeneic stem cell transplantation (allo-SCT). | 23601505 |
| Sample Size Calculation | Stem Cell Exhaustion | Circulating endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) were measured in the peripheral blood of 60 consecutive SSc patients. | 23601622 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Long-term clinical implications of embryonic stem cell markers such as Oct4 and Nanog have not been investigated in ST-elevation myocardial infarction (STEMI) patients. | 23602281 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Cardiovascular event rates in patients with ST-elevation myocardial infarction were lower with early increases in mobilization of Oct4(high)Nanog(high) stem cells into the peripheral circulation during a 4-year follow-up. | 23602281 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Side population (SP) cells, exhibiting stem cell-like properties, express ABCG2 (breast cancer resistance protein [BCRP]). | 23603434 |
| leukemia, Acute leukemia | Stem Cell Exhaustion | Both the occurrence and recurrence of acute leukemia (AL) might suggest the presence of leukemia stem cells. | 23603434 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | In acute myeloid leukemia (AML) patients before/after immunotherapy (stem cell transplantation or donor lymphocyte infusion), their suppressive role can contribute to suppress severe graft-versus-host reactions, but also to impair antileukemic reactions. | 23603857 |
| Acute lymphocytic leukemia, BCR gene | Stem Cell Exhaustion | Early T-cell precursor (ETP) acute lymphoblastic leukemia (ALL) is a high-risk subgroup of T-lineage ALL characterized by specific stem cell and myeloid features. | 23603912 |
| Neoplasms | Stem Cell Exhaustion | The tumor promoting effect of PKCa loss was reflected in enhanced Kras-mediated expansion of bronchio-alveolar stem cells (BASCs), putative tumor-initiating cells, both in vitro and in vivo. | 23604119 |
| Multiple Myeloma | Stem Cell Exhaustion | Role of high-dose melphalan with autologous stem cell transplantation in multiple myeloma patients receiving botezomib-containing induction therapy. | 23605366 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | To examine the role of high-dose melphalan therapy with autologous stem cell transplantation (HDM/ASCT) in the final outcomes of multiple myeloma (MM) patients receiving bortezomib-containing induction therapy (IT), we analyzed relationships between quality of response after IT including bortezomib or HDM/ASCT and survival. | 23605366 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Optimal timing of allogeneic hematopoietic stem cell transplantation in patients with myelodysplastic syndrome. | 23606215 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (HSCT) represents the only curative treatment for patients with myelodysplastic syndrome (MDS), but involves non-negligible morbidity and mortality. | 23606215 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Resistance to chemotherapy is a major obstacle for the effective treatment of breast cancer and is partially due to the presence of drug resistant stem cell-like side population (SP). | 23606360 |
| Specialty Type - cancer | Stem Cell Exhaustion | SP cells showed cancer stem cells (CSCs) properties, including self-renewal, resistance to chemotherapy and high expression of stem cell markers. | 23606360 |
| Neutropenia | Stem Cell Exhaustion | Risk factors of Ganciclovir-related neutropenia after allogeneic stem cell transplantation: a retrospective monocentre study on 547 patients. | 23607363 |
| Neutropenia | Stem Cell Exhaustion | The aim of this retrospective study was to identify factors associated with the occurrence of grade III-IV neutropenia among patients receiving pre-emptive Ganciclovir therapy after allogeneic stem cell transplantation at our Institution. | 23607363 |
| Neutropenia | Stem Cell Exhaustion | This large analysis revealed three risk factors for Ganciclovir-related neutropenia among patients with CMV reactivation after allogeneic stem cell transplantation; prompt identification of patients at risk when antiviral therapy is started may allow clinicians to adopt adequate preventive measures, so reducing the morbidity and mortality associated with CMV reactivation. | 23607363 |
| Scleroderma , Sample Size Calculation | Stem Cell Exhaustion | Mesenchymal stem cells (MSCs) from scleroderma patients (SSc) preserve their immunomodulatory properties although senescent and normally induce T regulatory cells (Tregs) with a functional phenotype: implications for cellular-based therapy. | 23607751 |
| Sample Size Calculation | Stem Cell Exhaustion | The aim of our work was to address how SSc-mesenchymal stem cells (MSCs), although senescent, might preserve specific immunomodulatory abilities during SSc. | 23607751 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Plerixafor is a recently introduced agent used to improve peripheral blood stem cell (PBSC) mobilization in patients with hematologic malignancies. | 23607889 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | Immunohistochemical staining was employed to examine expression of stem cell marker CD44 and drug-resistance protein thymidylate synthase (TS) in 71 cases with gastric cancer. | 23608803 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | [Isolation of gastric cancer stem cells based on colony morphology and detection of their sensitivity to 5-fluorouracil]. | 23608803 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | To investigate the sensitivity of gastric cancer stem cells (GCSCs) to 5-fluorouracil (5-FU), and to explore the cytological mechanism of drug-resistance of gastric cancer. | 23608803 |
| Stomach Carcinoma | Stem Cell Exhaustion | Clinicopathologic significance of putative stem cell marker, CD44 and CD133, in human gastric carcinoma. | 23609373 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | We examined the survival of patients with PTCL after relapse or progression in the absence of hematopoietic stem-cell transplantation and explored factors influencing survival. | 23610113 |
| Leukemia, Myelomonocytic, Chronic | Stem Cell Exhaustion | [Allogeneic hematopoietic stem cell transplantation for chronic myelomonocytic leukemia: a report of 12 patients]. | 23611216 |
| Leukemia, Myelomonocytic, Chronic | Stem Cell Exhaustion | To retrospectively review the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for chronic myelomonocytic leukemia (CMML). | 23611216 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Patients affected by hematological malignancies can often benefit from high dose chemotherapy followed by peripheral blood stem cells (PBSCs) transplantation. | 23611684 |
| Heart failure | Stem Cell Exhaustion | Impact of intracoronary reinfusion of bone marrow-derived mononuclear progenitor cells on cardiopulmonary exercise capacity in patients with chronic postinfarction heart failure. | 23612920 |
| Heart failure, Congestive heart failure | Stem Cell Exhaustion | Intracoronary infusion of bone marrow-derived progenitor cells (BMC) in patients with chronic ischaemic heart failure (CHF) is associated with improvement in left ventricular ejection fraction (LVEF), reduction of NT-proBNP levels and improved prognosis. | 23612920 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Adipose-derived mesenchymal stem cells exert antiinflammatory effects on chondrocytes and synoviocytes from osteoarthritis patients through prostaglandin E2. | 23613363 |
| Degenerative polyarthritis | Stem Cell Exhaustion | To examine the effect of different sources of good manufacturing practice clinical grade adipose-derived mesenchymal stem cells (AD-MSCs) on inflammatory factors in osteoarthritic (OA) chondrocytes and synoviocytes. | 23613363 |
| Intraepithelial Neoplasia, Specialty Type - cancer, Squamous cell carcinoma | Stem Cell Exhaustion | Putative cancer stem cell marker expression in oral epithelial dysplasia and squamous cell carcinoma. | 23614644 |
| Specialty Type - cancer | Stem Cell Exhaustion | Semi-quantitative immunohistochemical assessment of four putative cancer stem cell markers (CD24, CD44, CD271 and ALDH1) was conducted with a training cohort of 107 patient biopsies to establish clinically applicable score threshold values that were subsequently applied to a blind diagnosis in an independent validation cohort of 278 biopsies. | 23614644 |
| Specialty Type - cancer | Stem Cell Exhaustion | The hypothesised existence of cancer stem cells in dysplastic oral tissues provides the potential for more informed assessment of PMOL progression. | 23614644 |
| Stomach Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | WNT5A is a key regulator of the epithelial-mesenchymal transition and cancer stem cell properties in human gastric carcinoma cells. | 23615002 |
| Specialty Type - cancer | Stem Cell Exhaustion | Transduction of exogenous WNT5A expression into MKN-7 cells upregulated genes related to the epithelial-mesenchymal transition (EMT) and cancer stem cells (CSCs), and the pWNT5A transfectant showed high tumorigenicity in vivo. | 23615002 |
| Multiple Myeloma | Stem Cell Exhaustion | Bisphosphonate treatment and renal function in 201 myeloma patients undergoing stem cell transplantation. | 23616219 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Normal karyotype mosaicism in adult AML patients with adverse-risk and undefined karyotype: preliminary report of treatment outcomes after hematopoietic stem cell transplantation. | 23616221 |
| Aggressive behavior, Hollings Cancer Center, Secondary Neoplasm | Stem Cell Exhaustion | In HCC, presence of stem cell-like, epithelial cell adhesion molecule (EpCAM)-positive cells correlates with tumor aggressiveness and formation of metastasis. | 23616258 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | We evaluated the predictive value of [(18)F]fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) for clinical outcome such as progression-free survival (PFS) and overall survival (OS) in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) prior to and after autologous stem cell transplant (ASCT). | 23617323 |
| Stanford Cancer Institute | Stem Cell Exhaustion | Subjects with SCI also exhibited significantly higher plasma levels of monokine induced by interferon-gamma/chemokine C-X-C motif ligand 9 (P<.03), macrophage colony stimulating factor (P<.035), interleukin-3 (P<.044), and stem cell growth factor beta (SCGF-b) (P<.016). | 23618747 |
| Glioblastoma Multiforme Pathway, Neoplasms | Stem Cell Exhaustion | It has been shown to suppress the tumourigenicity of glioma stem cells in vivo, thereby being hypothesised to function as a tumour suppressor. | 23619925 |
| Bone Marrow, Leukemia, Myelocytic, Acute, peripheral blood | Stem Cell Exhaustion | Univariate analysis identified the absence of peripheral blood blasts and <20% bone marrow blasts as prognostic factors for both overall response and survival, but not age, ECOG/PS, type of AML, cytogenetic, status of the disease, number of previous lines of therapy, previous hematological stem cell transplantation, or white blood cells count. | 23619977 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | Comparable long-term outcomes after reduced-intensity conditioning versus myeloablative conditioning allogeneic stem cell transplantation for adult high-risk acute lymphoblastic leukemia in complete remission. | 23620000 |
| Acute GVH disease | Stem Cell Exhaustion | Acute graft-versus-host disease in a nonhematopoietic stem cell transplantation candidate treated with decitabine followed by granulocyte colony-stimulating factor-primed peripheral blood stem cells infusion: a special entity of the disease? | 23621702 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | With a well-developed strategy of acute graft-versus-host disease (aGVHD) prophylaxis, the prognosis of allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients who develop aGVHD has improved considerably. | 23621702 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | This report describes a 64-year-old male non-HSCT candidate diagnosed with acute myeloid leukemia who had received decitabine followed by an infusion of granulocyte-colony-stimulating factor-primed peripheral blood stem cells (G-PBSCs) from his daughter, who carried haploidentical human leukocyte antigen. | 23621702 |
| Kidney Failure, Chronic, Dominica, Diabetes Mellitus | Stem Cell Exhaustion | The aim of this study was to investigate the effect of end-stage renal disease (ESRD) and diabetes mellitus (DM) on the number of stem cells in the peripheral blood. | 23625296 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | Oral mucositis (OM) is one of the side effects of hematopoietic stem cell transplantation (HSCT), resulting in major morbidity. | 23625880 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Mesenchymal stem cell (MSC)-based therapy presents a promising approach for treating osteoarthritis (OA). | 23627821 |
| Hodgkin Disease, Neoplasms, Childhood Non-Hodgkin Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | We enrolled a total of 145 patients into the study (non-Hodgkin lymphoma (n: 40), Hodgkin lymphoma (n: 36), myeloma (n: 64), solid tumors (n:5)) who received autologous stem cell transplantation between 2009 and 2012. | 23628357 |
| Mycoses | Stem Cell Exhaustion | Voriconazole (VCZ) is frequently utilized for prevention and treatment of invasive fungal infections in peripheral stem cell transplant (PSCT) patients. | 23629717 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The survival of patients with relapsed acute myelogenous leukemia (AML) after autologous hematopoietic stem cell transplantation (auto-HCT) is very poor. | 23632091 |
| Hematopoietic Stem Cell Mobilization | Stem Cell Exhaustion | If their effectiveness is confirmed, statins could be a safe and cheaper addition to chemotherapy and plerixafor for peripheral hematopoietic stem cell mobilization. | 23632813 |
| Multiple Myeloma | Stem Cell Exhaustion | This study examines if statins may have the same effect in mobilizing marrow progenitors to be harvested and subsequently used in high-dose chemotherapy with progenitor cell rescue in multiple myeloma. | 23632813 |
| Multiple Myeloma | Stem Cell Exhaustion | Statin use and peripheral blood progenitor cells mobilization in patients with multiple myeloma. | 23632813 |
| Multiple Myeloma | Stem Cell Exhaustion | This retrospective analysis of 86 patients shows for the first time a possible benefit of statins for peripheral blood progenitor cells mobilization in patients with multiple myeloma. | 23632813 |
| Agave | Stem Cell Exhaustion | GAVE can develop as a complication of hematopoietic stem cell transplantation (HSCT-GAVE), and it has been suggested that it may be associated with oral administration of busulfan. | 23632949 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Donor leukocyte infusion (DLI) can induce potent graft-versus-leukemia (GVL) activity in patients with relapsed hematologic malignancies after allogeneic hematopoietic stem cell transplantation (HSCT). | 23635453 |
| Musculoskeletal, Specialty Type - cancer | Stem Cell Exhaustion | Sphere-forming cell subsets with cancer stem cell properties in human musculoskeletal sarcomas. | 23636271 |
| Sarcoma, Specialty Type - cancer | Stem Cell Exhaustion | Here, we report the identification of putative cancer stem cells (CSCs) in sarcomas using a sphere culture system. | 23636271 |
| Lymphoproliferative Disorders | Stem Cell Exhaustion | The kinetics and apoptotic profile of circulating endothelial cells in autologous hematopoietic stem cell transplantation in patients with lymphoproliferative disorders. | 23636312 |
| Malignant Neoplasms, Multiple Myeloma | Stem Cell Exhaustion | Measurements of circulating endothelial cells (CEC), their subsets and kinetics were taken in patients with lymphoid malignancies (37 multiple myeloma, ten lymphoma) during autologous hematopoietic stem cell transplantation (HSCT). | 23636312 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cells (CSCs) refer to a subset of tumor cells that self-renew and affect tumor heterogeneity. | 23636800 |
| SERPINB3 wt Allele, Specialty Type - cancer | Stem Cell Exhaustion | The objective of this study was to determine protein expression of cancer stem cell factor Bmi1 in a longitudinal series of patients with OLP and evaluate the correlation between Bmi1 expression and the risk of progression to OSCC. | 23639414 |
| Vascular System Injuries | Stem Cell Exhaustion | Although endothelial progenitor cells (EPCs) have been reported to promote neovessel formation during vascular injury, the function of supporting cells of EPCs and their interaction with EPCs during EPC isolation remain unclear. | 23640491 |
| Retinoblastoma | Stem Cell Exhaustion | Retinoblastoma is the most common primary intraocular malignancy of childhood, arising from retinal progenitor cells. | 23640512 |
| Cystitis, Neoplasms, Carcinoma, Transitional Cell | Stem Cell Exhaustion | In some cases, tumor development is thought to be associated with Brunns nests, cystitis cystica and urothelial carcinoma stem cells. | 23641713 |
| Malignant tumor of colon | Stem Cell Exhaustion | A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells. | 23642368 |
| Malignant tumor of colon, Neoplasms | Stem Cell Exhaustion | Here, we show that the tumor suppressor microRNA miR-34a is a cell-fate determinant in early-stage dividing colon cancer stem cells (CCSCs). | 23642368 |
| Multiple Myeloma | Stem Cell Exhaustion | In this study, we retrospectively analyzed MRD by quantitative real-time IgH-PCR (IgH-qPCR) in the PB of 42 patients undergoing high-dose therapy followed by autologous PB stem cell transplantation as first-line therapy for multiple myeloma. | 23644045 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | Outcomes of adults with acute lymphoblastic leukemia relapsing after allogeneic hematopoietic stem cell transplantation. | 23644077 |
| Acute lymphocytic leukemia, BCR gene | Stem Cell Exhaustion | For patients with acute lymphoblastic leukemia (ALL) who relapse after allogeneic hematopoietic stem cell transplantation (HSCT), treatment options are limited, and the clinical course and prognostic factors affecting outcome have not been well characterized. | 23644077 |
| Goiter | Stem Cell Exhaustion | In thyroid stem/progenitor cells derived from nodular goitres, the ability of 17b-oestradiol (E2) to induce the formation of thyrospheres and the expression of oestrogen receptors (ERs) and the effect of E2 on the growth and expression of markers of stem cells and thyroid differentiation (TSH receptor, thyroperoxidase, thyroglobulin and sodium iodide symporter (NIS)) were analysed. | 23645248 |
| Multiple Myeloma | Stem Cell Exhaustion | Natural history and prognostic impact of oligoclonal humoral response in patients with multiple myeloma after autologous stem cell transplantation: long-term results from a single institution. | 23645688 |
| Multiple Myeloma | Stem Cell Exhaustion | The emergence of an oligoclonal humoral response, resulting in the appearance of a different serum M-protein to that observed at diagnosis is a well-recognized event after autologous stem cell transplantation in multiple myeloma in complete response, and it has been considered to be a benign phenomenon. | 23645688 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | We conclude that escalated subcutaneous doses of alemtuzumab given weekly are well tolerated and result in excellent bone marrow clearance of chronic lymphocytic leukemia, helping patients to proceed to stem cell transplantation. | 23645694 |
| Intrahepatic Cholangiocarcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Clinical significances of cancer stem cells markers in patients with intrahepatic cholangiocarcinoma who underwent hepatectomy. | 23645762 |
| Intrahepatic Cholangiocarcinoma, Specialty Type - cancer | Stem Cell Exhaustion | The present study aimed to elucidate the relationship between cancer stem cells markers (CSCs), according to cell adhesion molecule (CD44) and glioma-associated oncogene homolog-1 (GLI1) expression, and clinicopathological factors and prognosis in 38 patients with intrahepatic cholangiocarcinoma (ICC) who underwent hepatectomy. | 23645762 |
| Acute leukemia | Stem Cell Exhaustion | A phase I study of CPX-351 in combination with busulfan and fludarabine conditioning and allogeneic stem cell transplantation in adult patients with refractory acute leukemia. | 23648237 |
| Acute leukemia | Stem Cell Exhaustion | This phase I study evaluated the maximal tolerated dose of CPX-351 when administered sequentially with allogeneic hematopoietic stem cell transplantation (HSCT) in patients with refractory acute leukemia. | 23648237 |
| Inflammatory Bowel Diseases, Colitis, HIV Infections | Stem Cell Exhaustion | We therefore evaluated quantitative, real-time CMV PCR in a total of 102 FFPE GI biopsy specimens from 74 patients with a history of hematopoietic stem cell or solid organ transplant, inflammatory bowel disease, human immunodeficiency virus infection, or unspecified colitis. | 23648457 |
| Multiple Myeloma | Stem Cell Exhaustion | The response to second-line induction with bortezomib and dexamethasone is predictive of long-term outcomes prior to high-dose chemotherapy with autologous stem cell transplantation for multiple myeloma. | 23648714 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | We retrospectively investigated the efficacy and predictive factors for the treatment outcomes of bortezomib plus dexamethasone (BD) as second-line induction therapy prior to high-dose chemotherapy supported by autologous stem cell transplantation (HDT/ASCT) in multiple myeloma (MM) patients. | 23648714 |
| Hematologic Neoplasms | Stem Cell Exhaustion | In this study, we retrospectively evaluated the antiemetic effectiveness and safety of aprepitant (a neurokinin-1 receptor antagonist) in addition to 5-HT3 antagonist in Japanese patients with hematologic malignancy receiving high-dose chemotherapy prior to autologous peripheral blood stem cell transplantation (auto-PBSCT). | 23649338 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | Effective and less aggressive therapies are required for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) who are not eligible for or have undergone autologous stem-cell transplantation (ASCT). | 23650408 |
| Acute myocardial infarction | Stem Cell Exhaustion | A critical challenge: dosage-related efficacy and acute complication intracoronary injection of autologous bone marrow mesenchymal stem cells in acute myocardial infarction. | 23651816 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Steroid refractory gastrointestinal (GI) acute graft-versus-host disease (aGVHD) is a major cause of mortality in hematopoietic stem cell transplantation (HCT) without immune markers to establish a diagnosis or guide therapy. | 23652802 |
| Colitis | Stem Cell Exhaustion | He was treated with 1 course of methylprednisolone pulse therapy and the clinical symptoms improved; however, the colitis was difficult to control even with immunosuppressive drugs, and he eventually required hematopoietic stem cell transplantation 1 year after the onset of MAS. | 23652865 |
| Encephalomyelitis, Acute Disseminated, Encephalomyelitis, Acute leukemia, Acute lymphocytic leukemia | Stem Cell Exhaustion | Acute disseminated encephalomyelitis (ADEM) has been reported in acute leukemia and after stem cell transplantation, but ADEM as a presenting feature in pediatric acute lymphoblastic leukemia is rare. | 23652871 |
| Hypogonadism | Stem Cell Exhaustion | Testosterone replacement therapy can increase circulating endothelial progenitor cell number in men with late onset hypogonadism. | 23653307 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Colistin is relatively safe in hematological malignancies and hematopoietic stem cell transplantation patients. | 23653428 |
| Hematologic Neoplasms, Toxic effect | Stem Cell Exhaustion | The aim of this study was to analyze the toxicity of colistin therapy in adults and children with hematological malignancies (HM) and hematopoietic stem cell transplantation (HSCT) recipients. | 23653428 |
| Decreased platelet count | Stem Cell Exhaustion | Eligible patients were persons 16 years of age or older who were receiving chemotherapy or undergoing stem-cell transplantation and who had or were expected to have thrombocytopenia. | 23656642 |
| Hemorrhage | Stem Cell Exhaustion | A prespecified subgroup analysis identified similar rates of bleeding in the two study groups among patients undergoing autologous stem-cell transplantation. | 23656642 |
| Adenocarcinoma of lung (disorder), Specialty Type - cancer | Stem Cell Exhaustion | Pulmonary Adenocarcinoma in Malignant Pleural Effusion Enriches Cancer Stem Cell Properties during Metastatic Cascade. | 23658677 |
| Specialty Type - cancer | Stem Cell Exhaustion | The objective of the current study was to confirm whether cancer stem cells (CSCs) in MPE contribute to the "metastatic cascade" through the epithelial - mesenchymal transition (EMT), anoikis, and adaptation in the microenvironment. | 23658677 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease (GVHD) is associated with morbidity and mortality in the recipients of allogeneic hematopoietic stem cell transplants (allo-HSCTs). | 23659674 |
| Trial Disease Assessments Domain, Multiple Myeloma | Stem Cell Exhaustion | We performed a molecular study aimed at identifying a gene expression profile (GEP) signature predictive of attainment of at least near complete response (CR) to thalidomide-dexamethasone (TD) as induction regimen in preparation for double autologous stem cell transplantation in 112 younger patients with newly diagnosed multiple myeloma. | 23660628 |
| Aspergillosis | Stem Cell Exhaustion | Comparison of a novel Aspergillus lateral-flow device and the Platelia(r) galactomannan assay for the diagnosis of invasive aspergillosis following haematopoietic stem cell transplantation. | 23661288 |
| Hyperpigmentation, Melanosis | Stem Cell Exhaustion | We previously reported that increased expression of the endothelin (EDN)1/EDNB receptor (EDNBR) as well as the stem cell factor (SCF)/SCF receptor (c-KIT) linkages is mainly responsible for the activation of melanocytes in the epidermal hyperpigmentation of ultraviolet (UV)-B melanosis and lentigo senilis (LS). | 23662587 |
| B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1, BCR gene | Stem Cell Exhaustion | Hematopoietic stem cell transplant versus chemotherapy plus tyrosine kinase inhibitor in the treatment of pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL). | 23664604 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We report a case of 53year old female with history of acute myelogenous leukemia, for which she underwent allogeneic peripheral blood stem cell transplant; her course was complicated by chronic graft versus host disease. | 23664606 |
| Toxic effect, Comorbidity | Stem Cell Exhaustion | Reduced toxicity conditioning and allogeneic stem cell transplantation in adults using fludarabine, carmustine, melphalan, and antithymocyte globulin: outcomes depend on disease risk index but not age, comorbidity score, donor type, or human leukocyte antigen mismatch. | 23664940 |
| Cardiovascular Diseases, Diabetes | Stem Cell Exhaustion | Here we report the effects of NO on both promotion and inhibition of cell proliferation, in particular in regard to cardiovascular disease, diabetes, and stem cells. | 23665095 |
| Failure | Stem Cell Exhaustion | This case illustrates that SLET is effective in treating LSCD even in cases that are conventionally considered to be at high risk for failure of limbal stem cell transplantation. | 23667247 |
| Multiple Myeloma | Stem Cell Exhaustion | [Analysis of the efficacy and prognosis on first-line autologous hematopoietic stem cell transplantation of patients with multiple myeloma]. | 23668200 |
| Trial Disease Assessments Domain | Stem Cell Exhaustion | All patients received thalidomide or/and bortezomib-based induction therapy, then received high-dose melphalan (200 mg/m2) and autologous stem cell support to get a >= partial response (PR), and followed by thalidomide-dexamethasone (TD) +-bortezomib as consolidation or maintenance treatment. | 23668200 |
| Multiple Myeloma, Communicable Diseases | Stem Cell Exhaustion | [Observation of humoral immunity reconstitution and its relationship with infection after autologous hematopoietic stem cell transplantation for patients with multiple myeloma]. | 23668204 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma, Communicable Diseases | Stem Cell Exhaustion | To study the humoral immunity reconstitution and its relationship with infection in patients with multiple myeloma (MM) after undergoing autologous hematopoietic stem cell transplantation (auto-HSCT). | 23668204 |
| Multiple Myeloma | Stem Cell Exhaustion | [Clinical significance of abnormal protein bands in multiple myeloma treated with bortezomib-based induction regimen and autologous stem cell transplantation]. | 23668206 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | To study the clinical significance of abnormal protein bands (APB) in multiple myeloma (MM) patients treated with bortezomib-based induction regimen and autologous stem cell transplantation (ASCT). | 23668206 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Similar properties of chondrocytes from osteoarthritis joints and mesenchymal stem cells from healthy donors for tissue engineering of articular cartilage. | 23671648 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | BAALC and WT1 expressions from diagnosis to hematopoietic stem cell transplantation: consecutive monitoring in adult patients with core-binding-factor-positive AML. | 23672350 |
| Core binding factor acute myeloid leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | No consecutive analysis of BAALC and WT1 expressions associated with core-binding factor AML (CBF-AML) from diagnosis to hematopoietic stem cell transplantation (HSCT) has yet been reported. | 23672350 |
| Malignant Neoplasms | Stem Cell Exhaustion | Various experimental studies indicate potential involvement of bone marrow (BM)-derived stem cells (SCs) in malignancy development and progression. | 23672538 |
| Pancreatic carcinoma | Stem Cell Exhaustion | In contrast to previous studies, we demonstrate herein that systemic SDF-1 levels do not seem to be linked with increased mobilization of stem cells in patients with pancreatic cancer. | 23672538 |
| Pancreatic carcinoma | Stem Cell Exhaustion | An intensified systemic trafficking of bone marrow-derived stem/progenitor cells in patients with pancreatic cancer. | 23672538 |
| Pancreatic carcinoma | Stem Cell Exhaustion | In this study, we comprehensively analysed systemic trafficking of various populations of BM-derived SCs (BMSCs), i.e., mesenchymal, haematopoietic, endothelial stem/progenitor cells (MSCs, HSCs, EPCs respectively), and of recently discovered population of very small embryonic/epiblast-like SCs (VSELs) in pancreatic cancer patients. | 23672538 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | A 3-year-old girl with acute myeloid leukemia underwent unrelated cord blood stem cell transplantation (UCBT) due to primary induction failure. | 23676648 |
| Zygomycosis | Stem Cell Exhaustion | [Fatal zygomycosis caused by Mucor indicus after haplo-identical stem cell transplantation]. | 23676649 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | We report the case of a 10 year old girl with a relapsed acute lymphoblastic leukemia, who underwent a haploidentical hematopoietic stem cell transplant (HSCT), with grade II skin and digestive graft versus host disease, treated with corticosteroids and cyclosporine. | 23677159 |
| Aortic Aneurysm, Abdominal | Stem Cell Exhaustion | Perspectives on stem cell-based elastic matrix regenerative therapies for abdominal aortic aneurysms. | 23677642 |
| Specialty Type - cancer, Pancreatic carcinoma | Stem Cell Exhaustion | CD44(+) /CD24(+) /EpCAM(+) cells have been reported to be cancer stem cells in pancreatic cancer; however, the histological and clinical importance of these cells has not yet been investigated. | 23679813 |
| Chronic granulomatous disease | Stem Cell Exhaustion | Successful Unrelated Cord Blood Stem Cell Transplantation in an X-linked Chronic Granulomatous Disease Patient with Disseminated BCG-induced Infection. | 23680261 |
| In-Stent Restenosis Indicator, Acute Coronary Syndrome | Stem Cell Exhaustion | Circulating endothelial progenitor cells are inversely correlated with in-stent restenosis in patients with non-ST-segment elevation acute coronary syndromes treated with EPC-capture stents (JACK-EPC trial). | 23681133 |
| GDC AJCC Clinical Stage Terminology, Acute Coronary Syndrome | Stem Cell Exhaustion | Aim of the study was to evaluate the association between circulating endothelial progenitor cells (EPCs) and angiographic outcomes after implantation of GenousTM stent in patients with non-ST-segment elevation acute coronary syndromes (ACS) (NSTE-ACS) undergoing urgent percutaneous coronary intervention (PCI). | 23681133 |
| Specialty Type - cancer | Stem Cell Exhaustion | Circulating endothelial cells (CECs), endothelial progenitor cells (EPCs), Willebrand factor (vWf), soluble E-selectin, vascular endothelial growth factor (VEGF) and angiogenin are of interest in cancer vascular biology. | 23683169 |
| Malignant neoplasm of lung | Stem Cell Exhaustion | The purpose of this study is to investigate the differential expression and clinical significance of seven stem-cell-associated markers (Bmi1, CD133, CD44, Sox2, Nanog, OCT4 and Msi2) in lung cancer, providing new targets for the diagnosis and treatment of lung cancer. | 23683495 |
| Malignant neoplasm of lung, Non-Cancer Related Death | Stem Cell Exhaustion | In this study, we evaluated the differential expression of mRNA levels seven stem-cell-associated markers by semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) from 112 human lung cancer and 18 non-cancer tissues obtained by bronchoscopy. | 23683495 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Prognostic factors for outcomes of allogeneic stem cell transplantation in chronic phase chronic myeloid leukemia in the era of tyrosine kinase inhibitors. | 23684143 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | The aim of this study was to estimate the prognostic factors for the outcomes of chronic myeloid leukemia (CML) patients receiving allogeneic stem cell transplantation (SCT) in chronic phase (CP) in the era of tyrosine kinase inhibitors (TKIs). | 23684143 |
| Disease, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Acute leukemia, hematopoietic stem cell differentiation | Stem Cell Exhaustion | Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell disorders characterized by abnormal hematopoietic differentiation and maturation, which progress toward acute leukemia in approximately 30% of the cases. | 23684483 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Tumors of the mesenchymal subtype contain cells with features of cancer stem cells, and cell lines of this subtype are particularly sensitive to phosphatidylinositol 3-kinase-AKT-mTOR inhibitors in vitro. | 23684942 |
| Multiple Myeloma | Stem Cell Exhaustion | Vaccination with dendritic cell/tumor fusions following autologous stem cell transplant induces immunologic and clinical responses in multiple myeloma patients. | 23685836 |
| Aspergillosis | Stem Cell Exhaustion | Given the difficulty in distinguishing S. commune infection from aspergillosis by standard culture methods, the incidence of S. commune infection following allogeneic hematopoietic stem cell transplantation may be underestimated. | 23686329 |
| Inflammation, Endothelial dysfunction, Platelet aggregation | Stem Cell Exhaustion | Inhibition of platelet aggregation by nitric oxide (primary outcome measure), vascular endothelial function, plasma concentrations of N(G), N(G)-dimethyl-L-arginine (ADMA), endothelial progenitor cell count, and high-sensitivity C-reactive protein (markers of endothelial dysfunction and inflammation) were assessed. | 23688663 |
| Mycoses | Stem Cell Exhaustion | [Itraconazole for secondary prophylaxis of invasive fungal infection in patients undergoing chemotherapy and stem cell transplantation]. | 23688752 |
| Agranulocytosis lab result, Mycoses | Stem Cell Exhaustion | To evaluate the efficacy and safety of itraconazole for secondary prophylaxis of previous proven or probable invasive fungal infection (IFI) in patients undergoing chemotherapy or allogeneic hematopoietic stem cell transplantation (HSCT) in agranulocytosis state. | 23688752 |
| Bone Marrow, Hypernatremia | Stem Cell Exhaustion | Mechanisms underlying bone marrow damage by iron overload might be through the follows: 1The increased ROS induced by excessive iron deposition affected the expressions of Caspase-3 and Bcl-2, which caused more BMMNC apoptosis; 2The abnormal number and ratio of T lymphocytes caused by iron overload aggravated the abnormality of immunity of IRP; 3Iron overload may increase the damage to erythrocytes and stem cells coated with auto-antibodies. | 23688756 |
| Waldenstrom Macroglobulinemia, Amyloidosis | Stem Cell Exhaustion | Waldenstrom's macroglobulinemia associated with serum amyloid A protein amyloidosis: pitfalls in diagnosis and successful treatment with melphalan-based autologous stem cell transplant. | 23689541 |
| Amyloidosis | Stem Cell Exhaustion | Autologous stem cell transplant (ASCT) is now being increasingly used for the treatment of amyloidosis, but most studies are small case series. | 23689541 |
| Neoplasms, Malignant Neoplasms | Stem Cell Exhaustion | In contrast, HCC/immortality genes were up-regulated in tumor tissues, or more malignant tumors and progenitor cells. | 23691139 |
| Infection | Stem Cell Exhaustion | Successful systemic high-dose ribavirin treatment of respiratory syncytial virus-induced infections occurring pre-engraftment in allogeneic hematopoietic stem cell transplant recipients. | 23692664 |
| Upper Respiratory Infections, Communicable Diseases | Stem Cell Exhaustion | Respiratory syncytial virus (RSV) is a frequent cause of respiratory tract infectious disease (RTID) in allogeneic hematopoietic stem cell transplant (HSCT) recipients associated with a high mortality once infection has progressed from upper RTID (URTID) to lower RTID (URTID). | 23692664 |
| Toxic effect | Stem Cell Exhaustion | Toxicity was largely hematologic, and stem cell mobilization was successful in 43 of 45 patients. | 23692856 |
| Neoplasms | Stem Cell Exhaustion | The residual tumors after response to the chemotherapy exhibited an increased expression in 51 (61%) of 84 genes related with stem cell proliferation and maintenance, particularly those in Notch and Wnt pathways, suggesting enrichment for stem cell populations in the residual tumors. | 23695169 |
| Specialty Type - cancer | Stem Cell Exhaustion | Anti-HDGF targets cancer and cancer stromal stem cells resistant to chemotherapy. | 23695169 |
| Non-Small Cell Lung Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | These data support the hypothesis that cancer stem cells (CSC) are a mechanism for chemotherapy resistance and suggest HDGF may be a target for repressing CSCs to prevent relapse of NSCLC sensitive to chemotherapy. | 23695169 |
| Immune System Diseases | Stem Cell Exhaustion | Discoveries of immunomodulatory functions in mesenchymal stem cells (MSCs) have suggested that they might have therapeutic utility in treating immune diseases. | 23697344 |
| Hodgkin Disease | Stem Cell Exhaustion | Improved outcome with busulfan, melphalan and thiotepa conditioning in autologous hematopoietic stem cell transplant for relapsed/refractory Hodgkin lymphoma. | 23697844 |
| Hodgkin Disease | Stem Cell Exhaustion | High-dose therapy with autologous stem cell transplant (autoSCT) is standard therapy for relapsed/refractory Hodgkin lymphoma, although the optimal conditioning regimen remains uncertain. | 23697844 |
| Malignant neoplasm of testis | Stem Cell Exhaustion | Plerixafor and autologous stem cell transplantation: impressive result in a chemoresistant testicular cancer patient treated with high-dose chemotherapy. | 23698254 |
| Lymphoma, Non-Hodgkin, Multiple Myeloma | Stem Cell Exhaustion | Plerixafor, a CXCR4 antagonist, induces the rapid release of hematopoietic progenitor stem cells from the bone marrow into peripheral blood; it is approved for autologous hematopoietic progenitor stem cell mobilization in multiple myeloma and non-Hodgkin's lymphoma patients. | 23698254 |
| Testicular Embryonal Carcinoma | Stem Cell Exhaustion | We report the case of a 34-year-old patient with metastatic testicular embryonal carcinoma who was extensively and in vain pretreated with chemotherapy and failed to mobilize an adequate number of hematopoietic progenitor stem cells following high-dose chemotherapy, with the support of granulocyte colony-stimulating factors. | 23698254 |
| Hypertension, CTCAE | Stem Cell Exhaustion | Bartter's/Gitelman's syndromes (BS/GS) are rare diseases that feature a picture opposite to that of hypertension in that they present with normo/hypotension, reduced oxidative stress and a lack of cardiovascular remodeling, notwithstanding high levels of angiotensin II and other vasopressors, upregulation of NO system, and increased NO-dependent vasodilation (FMD), as well as increase in both endothelial progenitor cells and insulin sensitivity. | 23698802 |
| Reperfusion Injury | Stem Cell Exhaustion | Erythropoietin (EPO) was hypothesized to mitigate reperfusion injury, in part via mobilization of endothelial progenitor cells (EPCs). | 23700090 |
| Nonunion of Bone | Stem Cell Exhaustion | The use of growth factors and autologous mesenchymal stem cells through the enforcement of system for tissue regeneration is a valid and innovative biotechnology technique for the treatment long bone nonunions. | 23700322 |
| Specialty Type - cancer | Stem Cell Exhaustion | Based on their main biological characteristics, we distinguished a deficient mismatch repair subtype, a KRAS mutant subtype, a cancer stem cell subtype, and three chromosomal instability subtypes, including one associated with down-regulated immune pathways, one with up-regulation of the Wnt pathway, and one displaying a normal-like gene expression profile. | 23700391 |
| Primary Myelofibrosis, Cytopenia, Adverse Event Associated with Constitutional Symptoms, Splenomegaly, PRSS27 gene | Stem Cell Exhaustion | Myelofibrosis (MF) is a Philadelphia chromosome-negative stem cell myeloproliferative neoplasm (MPN) associated with cytopenias, splenomegaly, constitutional symptoms, and poor prognosis. | 23701016 |
| Hematologic Neoplasms | Stem Cell Exhaustion | The study included 110 consecutive patients with hematological malignancies receiving fludarabine-based reduced intensity conditioning (RIC) and hematopoietic stem cell transplantation (HSCT) from matched unrelated donors. | 23701240 |
| Duodenal Ulcer | Stem Cell Exhaustion | Recently we conducted the genome wide association study for duodenal ulcer and identified disease susceptibility variations at two genetic loci corresponding to the Prostate stem cell antigen (PSCA) gene and the ABO blood group (ABO) gene. | 23704932 |
| SERPINB3 wt Allele, Specialty Type - cancer | Stem Cell Exhaustion | The objective of this study was to determine protein expression of cancer stem cell marker aldehyde dehydrogenase 1 (ALDH1) in a series of patients with OLP and evaluate the correlation between ALDH1 expression and the risk of progression to OSCC. | 23707659 |
| Angina Pectoris, Ischemia | Stem Cell Exhaustion | Patients (n = 444) receiving maximally tolerated antianginal therapies and lacking conventional revascularization options with Canadian Cardiovascular Society class III or IV angina and ischemia on stress testing will be randomized 2:1:1 to cell therapy (G-CSF-mediated stem cell mobilization, apheresis, and intramyocardial injection of 1 x 10(5) autologous CD34(+) cells/kg), active control (G-CSF-mediated stem cell mobilization, apheresis, and intramyocardial placebo injection), or open-label standard of care. | 23708155 |
| Angina Pectoris, Chronic myocardial ischemia | Stem Cell Exhaustion | RENEW is a pivotal phase 3 trial designed to determine the efficacy of granulocyte colony-stimulating factor (G-CSF)-mobilized CD34+ stem cells for the treatment for patients with refractory angina and chronic myocardial ischemia. | 23708155 |
| Multiple Myeloma | Stem Cell Exhaustion | Reduced intensity-conditioned allogeneic stem cell transplantation for multiple myeloma relapsing or progressing after autologous transplantation: a study by the European Group for Blood and Marrow Transplantation. | 23708704 |
| Kidney Failure, Chronic, Diabetes Mellitus, Insulin-Dependent | Stem Cell Exhaustion | Co-infusion of adipose tissue derived mesenchymal stem cell-differentiated insulin-making cells and haematopoietic cells with renal transplantation: a novel therapy for type 1 diabetes mellitus with end-stage renal disease. | 23709153 |
| Kidney Failure, Chronic | Stem Cell Exhaustion | We report a 30-year-old-man with T1DM since 15 years and ESRD since 2 years, who underwent living donor RT and co-infusion of in vitro generated insulin-making cells differentiated from donor adipose tissue derived mesenchymal stem cells and bone marrow -derived haematopoietic SC into subcutaneous tissue, portal and thymic circulation under non-myeloablative conditioning. | 23709153 |
| Spinal Cord Injuries, Muscle Spasticity | Stem Cell Exhaustion | Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation. | 23710605 |
| Trauma | Stem Cell Exhaustion | Intraspinal grafting of human neural stem cells represents a promising approach to promote recovery of function after spinal trauma. | 23710605 |
| Crushing injury | Stem Cell Exhaustion | Here we characterized the effect of intraspinal grafting of clinical grade human fetal spinal cord-derived neural stem cells (HSSC) on the recovery of neurological function in a rat model of acute lumbar (L3) compression injury. | 23710605 |
| Chronic graft-versus-host disease | Stem Cell Exhaustion | Chronic graft-versus-host disease of the kidney in patients with allogenic hematopoietic stem cell transplant. | 23710658 |
| Hematological Disease | Stem Cell Exhaustion | Allogenic hematopoietic stem cell transplant (allo-HSCT) is the treatment of choice for several hematological diseases. | 23710658 |
| Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Vaginal chronic graft-versus-host disease (cGVHD) is a common complication of stem cell transplantation. | 23710698 |
| Antilymphocyte Serum | Stem Cell Exhaustion | We have recently shown that human mesenchymal stem cells (hMSCs) modified to release glial cell line-derived neurotrophic factor (GDNF) decrease disease progression in a rat model of ALS when delivered to skeletal muscle. | 23712039 |
| Pregnancy Complications, Infectious, Immunocompromised Host | Stem Cell Exhaustion | Immunocompromised hematological patients undergoing cyclic chemotherapy treatment or allogeneic hemopoietic stem cell transplantation with infectious complications in which the infectious agents were identified during the disease course were evaluated. | 23712521 |
| Malignant neoplasm of lung | Stem Cell Exhaustion | In this study, we investigated the potential of the stem cell and progenitor cell marker, Musashi1 (Msi1), as a diagnostic marker and potential therapeutic target for lung cancer. | 23715514 |
| Trichoepithelioma | Stem Cell Exhaustion | PHLDA1, a follicular stem cell marker, differentiates clear-cell/granular-cell trichoblastoma and clear-cell/granular cell basal cell carcinoma: a case-control study, with first description of granular-cell trichoblastoma. | 23719479 |
| Trichoepithelioma | Stem Cell Exhaustion | PHLDA1 is a follicular stem cell marker, the expression of which has been reported to differentiate trichoepithelioma from BCCs. | 23719479 |
| Multiple Sclerosis, Relapsing-Remitting | Stem Cell Exhaustion | T-cell responses after haematopoietic stem cell transplantation for aggressive relapsing-remitting multiple sclerosis. | 23721329 |
| MS gene | Stem Cell Exhaustion | Autologous haematopoietic stem cell transplantation (HSCT) for relapsing-remitting multiple sclerosis is a potentially curative treatment, which can give rise to long-term disease remission. | 23721329 |
| Pericarditis, CTCAE | Stem Cell Exhaustion | Pericarditis mediated by respiratory syncytial virus in a hematopoietic stem cell transplant patient. | 23725410 |
| Pericarditis, CTCAE, Pericardial Effusion, CTCAE, Multiple Myeloma | Stem Cell Exhaustion | We describe a case of pericarditis and large pericardial effusion in a 63-year-old African-American man undergoing autologous hematopoietic stem cell transplant for multiple myeloma. | 23725410 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Polymerase chain reaction (PCR)-negative molecular complete remission (mCR) can be induced by stem cell transplantation in some patients with multiple myeloma (MM) and is associated with long-term progression-free survival (PFS). | 23727584 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | The introduction of autologous stem cell transplantation (SCT) and novel drugs has improved overall survival in multiple myeloma (MM) patients. | 23728352 |
| Inappropriate ADH Syndrome | Stem Cell Exhaustion | Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is an important electrolyte abnormality that can occur following allogeneic stem cell transplantation. | 23728560 |
| Amyloidosis | Stem Cell Exhaustion | Patients with immunoglobulin light chain amyloidosis who underwent autologous stem cell transplantation between 1995 and 2010 were recruited. | 23729727 |
| Proteinuria | Stem Cell Exhaustion | Eligibility criteria included >1 g/dL of proteinuria, dialysis independence at baseline and within the first year of autologous stem cell transplantation, and a minimum follow-up of 1 year. | 23729727 |
| Mycoses | Stem Cell Exhaustion | Association between drug tolerability and medical resource use in prophylaxis of invasive fungal infections after allogeneic hematopoietic stem cell transplant. | 23730943 |
| Infection | Stem Cell Exhaustion | To conduct a retrospective analysis of the association between drug tolerability and potential economic impact measured by medical resource utilization (MRU) for prophylaxis of invasive antifungal infections (IFI) after allogeneic hematopoietic stem cell transplantation (alloHCT). | 23730943 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | Occurrence of stem cell defects and of immune-mediated mechanisms was evidenced as relevant for pathophysiology of MDS. | 23734938 |
| Lymphoma | Stem Cell Exhaustion | Prognostic factors for survival in lymphoma patients after autologous stem cell transplantation. | 23740138 |
| Depression, CTCAE, Degenerative polyarthritis, Cerebrovascular accident | Stem Cell Exhaustion | A prior stroke, macular degeneration, osteoarthritis, and depression, led her to receive intrathecal neural stem cell therapy overseas 1 year before onset of symptoms. | 23740462 |
| Dominica, melphalan/prednisone protocol | Stem Cell Exhaustion | Circulating hematopoietic stem and progenitor cell (CHSPCAng) levels were detected at significantly lower concentrations in DM (P < 0.001), whereas levels of seven phenotypically distinct MPs were present at significantly higher concentrations in DM patients and one MP subset was present at significantly lower concentration in DM patients. | 23740755 |
| Inflammation, Thrombosis | Stem Cell Exhaustion | This study evaluated a novel high dimensional flow cytometry approach in combination with cytometric fingerprinting (CF), to comprehensively enumerate differentially expressed subsets of pro-angiogenic circulating progenitor cells (CPCs), involved in the repair of vasculature, and microparticles (MPs), frequently involved in inflammation and thrombosis. | 23740755 |
| Seizures | Stem Cell Exhaustion | Instead, we determined that the observed mutation distribution fits a germline selection model, where mutant spermatogonial stem cells have a proliferative advantage over unmutated cells. | 23740942 |
| Purpura, Thrombotic Thrombocytopenic | Stem Cell Exhaustion | Despite achieving similar CR rates after high-dose therapy/autologous stem cell transplantation vs other MM patients, MGUS-like cases had unprecedented longer time-to-progression (TTP) and overall survival (OS; ~60% at 10 years; P<0.001). | 23743858 |
| Electrocardiogram: myocardial infarction (finding), Vascular occlusion | Stem Cell Exhaustion | Endothelial progenitor cells, microvascular obstruction, and left ventricular remodeling in patients with ST elevation myocardial infarction undergoing primary percutaneous coronary intervention. | 23746481 |
| Colorectal Carcinoma | Stem Cell Exhaustion | Isolation and phenotypic characterization of colorectal cancer stem cells with organ-specific metastatic potential. | 23747337 |
| Specialty Type - cancer | Stem Cell Exhaustion | Migrating cancer stem cells (MCSCs) are believed to form metastases. | 23747337 |
| Mycoses | Stem Cell Exhaustion | Risk factors for invasive fungal disease after allogeneic hematopoietic stem cell transplantation: a single center experience. | 23747459 |
| Intrinsic Factor Deficiency, Mycoses | Stem Cell Exhaustion | Invasive fungal disease (IFD) is a major cause of morbidity and mortality after hematopoietic stem cell transplantation (HCT). | 23747459 |
| Supraventricular arrhythmia | Stem Cell Exhaustion | Incidence of supraventricular arrhythmias during autologous peripheral blood stem cell transplantation. | 23747600 |
| Cytomegaloviral colitis, Chronic Active Colitis, Metaplasia, Granuloma, Graft-vs-Host Disease | Stem Cell Exhaustion | These results demonstrate that chronic active colitis with granuloma and Paneth cell metaplasia is not only a specific feature of CCS but also is present in GVHD and CMV colitis, irrespective of stem cell source. | 23749110 |
| Toxoplasmosis | Stem Cell Exhaustion | Acute exacerbation of Toxoplasma gondii infection after hematopoietic stem cell transplantation: five case reports among 279 recipients. | 23749548 |
| Toxoplasmosis | Stem Cell Exhaustion | Toxoplasmosis is a rare and possibly underestimated complication following hematopoietic stem cell transplantation (HSCT) associated with a high mortality rate, although the incidence of toxoplasmosis after HSCT in Japan has not been established. | 23749548 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Plerixafor, a recently approved peripheral blood progenitor cell mobilizing agent, is often added to granulocyte-colony stimulating factor (G-CSF) to mobilize peripheral blood progenitor cells in patients with lymphoma or myeloma who cannot mobilize enough CD34+ cells with G-CSF alone to undergo autologous stem cell transplantation. | 23749720 |
| Hematopoietic Stem Cell Mobilization, "HODGKINS AND NON-HODGKINS LYMPHOMA", Multiple Myeloma | Stem Cell Exhaustion | We reviewed the peripheral blood stem cell collection data of 38 consecutive patients with lymphoma (Hodgkin's and non-Hodgkin's) and multiple myeloma who underwent chemomobilization and high-dose G-CSF and just-in-time plerixafor to evaluate the efficacy of this treatment combination. | 23749720 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | All patients with multiple myeloma and all but one patient with lymphoma collected the minimum required number of CD34+ cells to proceed with autologous stem cell transplantation (>2 x 10(6) /kg of body weight). | 23749720 |
| Malignant Peripheral Nerve Sheath Tumor, Myeloproliferative disease, Neoplasms | Stem Cell Exhaustion | Human myeloproliferative neoplasms (MPNs) are thought to reflect transformation of a hematopoietic stem cell (HSC) and the majority harbor an acquired V617F mutation in the JAK2 tyrosine kinase, making them a paradigm for studying the early stages of tumor establishment and progression. | 23750118 |
| JAK2 NP_004963.1:p.V617F | Stem Cell Exhaustion | Self-renewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion. | 23750118 |
| Neoplasms, Malignant Neoplasms | Stem Cell Exhaustion | Recent descriptions of significant heterogeneity in normal stem cells and cancers have altered our understanding of tumorigenesis, emphasizing the need to understand how single stem cells are subverted to cause tumors. | 23750118 |
| Malignant Neoplasms, Hemopoietic stem cell transplant | Stem Cell Exhaustion | Results Of the 1,011 patients, 38.2% had newly diagnosed malignancies, 23.1% were in remission, and 24.9% had received hematopoietic stem-cell transplantations (HSCT, including 145 allogeneic). | 23752112 |
| Hematologic Neoplasms | Stem Cell Exhaustion | This retrospective report compared the results of graft source on outcome after allogeneic stem cell transplantation (allo-SCT) in patients with hematologic malignancies receiving a reduced intensity conditioning (RIC) regimen. | 23752174 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Autologous peripheral blood stem cell transplantation with granulocyte colony-stimulating factor combined conditioning regimen as a postremission therapy for acute myelogenous leukemia in first complete remission. | 23754766 |
| Leukemia, Myelocytic, Acute, Non-M3 Acute Myeloid Leukemia | Stem Cell Exhaustion | We retrospectively analyzed the outcomes of 81 patients with non-M3 acute myelogenous leukemia (AML) in first complete remission (CR1) who were treated with high-dose chemotherapy (HDCT) and autologous peripheral blood stem cell transplantation (Auto-PBSCT) by the Fukuoka Blood and Marrow Transplantation Group between 1989 and 2005. | 23754766 |
| Spinal Cord Injuries | Stem Cell Exhaustion | We propose that these cells represent a useful tool both for the in vitro study of differentiation into ventral spinal cord neuronal subtypes, and for examining the potential of conditionally immortalized neural stem cells to facilitate functional recovery after spinal cord injury or disease. | 23759128 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Dose-intense etoposide-cyclophosphamide without stem cell transplantation for patients with intermediate and high cytogenetic risk primary refractory and relapsed acute myeloid leukemia. | 23759246 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Dose-intense etoposide-cyclophosphamide (D-I ECy) without stem cell transplantation has been used in salvage regimens for the treatment of resistant acute myeloid leukemia(AML). | 23759246 |
| Multiple Myeloma | Stem Cell Exhaustion | We present a 58-year-old man with recurrent multiple myeloma treated with 2 autologous stem cell transplantations. | 23759296 |
| Aspergillosis | Stem Cell Exhaustion | The serum galactomannan index predicts mortality in hematopoietic stem cell transplant recipients with invasive aspergillosis. | 23759343 |
| Immunocompromised Host, Toxoplasmosis, Communicable Diseases | Stem Cell Exhaustion | In immunocompromized patients, including hematopoietic stem cell transplant (HSCT) recipients, life-threatening toxoplasmosis may result from reactivation of previous infection. | 23761151 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Migratory activity of circulating progenitor cells and serum SDF-1a predict adverse events in patients with myocardial infarction. | 23761401 |
| Ischemic, Acute myocardial infarction | Stem Cell Exhaustion | Following acute myocardial infarction (AMI), pro-angiogenic progenitor cells (PCs) are released from the bone marrow into the circulation and home to the ischaemic site attracted by a chemokine gradient. | 23761401 |
| Hepatorenal Syndrome, LIPC gene | Stem Cell Exhaustion | Fifty adult patients with relapsed/refractory HL, adequate marrow reserve, hepatorenal and pulmonary functions, with radiological measurable disease and Karnofsky performance status of 0 - 2 non-candidates for stem cell transplantation, were enrolled. | 23763798 |
| Bone Marrow | Stem Cell Exhaustion | Three of these subjects also cleared bone marrow blasts with 1 subsequently proceeding onto successful stem cell transplantation. | 23763920 |
| Multiple Myeloma | Stem Cell Exhaustion | Temporal changes in plerixafor administration and hematopoietic stem cell mobilization efficacy: results of a prospective clinical trial in multiple myeloma. | 23764455 |
| Childhood Non-Hodgkin Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Plerixafor with granulocyte colony-stimulating factor (G-CSF) is effective for hematopoietic stem cell (HSC) mobilization in patients with non-Hodgkin Lymphoma and myeloma; however, labeling requires dosing 11 hours before apheresis. | 23764455 |
| Multiple Myeloma | Stem Cell Exhaustion | To address the effect of afternoon plerixafor dosing on CD34(+) cell yields, we conducted a prospective clinical trial in myeloma patients undergoing stem cell collection. | 23764455 |
| B-Cell Lymphomas | Stem Cell Exhaustion | Myeloablative anti-CD20 radioimmunotherapy +/- high-dose chemotherapy followed by autologous stem cell support for relapsed/refractory B-cell lymphoma results in excellent long-term survival. | 23765188 |
| Lymphoma | Stem Cell Exhaustion | Myeloablative anti-CD20 RIT followed by autologous stem cell infusion (ASCT) enables high radiation doses to lymphoma sites. | 23765188 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | A stem cell-like gene expression signature associates with inferior outcomes and a distinct microRNA expression profile in adults with primary cytogenetically normal acute myeloid leukemia. | 23765227 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Acute myeloid leukemia (AML) is hypothesized to be sustained by self-renewing leukemia stem cells (LSCs). | 23765227 |
| Multiple Myeloma | Stem Cell Exhaustion | Peripheral blood stem cell mobilization in multiple myeloma patients treat in the novel therapy-era with plerixafor and G-CSF has superior efficacy but significantly higher costs compared to mobilization with low-dose cyclophosphamide and G-CSF. | 23765597 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Studies comparing the efficacy and cost of peripheral blood stem and progenitor cells mobilization with low-dose cyclophosphamide (LD-CY) and granulocyte-colony stimulating factor (G-CSF) against plerixafor and G-CSF, in multiple myeloma (MM) patients treated in the novel therapy-era are not available. | 23765597 |
| Neoplasms, Hyperplasia | Stem Cell Exhaustion | Impaired mammary cell commitment upon RANK overexpression leads to the accumulation of progenitors including K14+K8+ bipotent cells and the formation of heterogeneous tumors containing hyperplastic basal, luminal, and progenitor cells. | 23766243 |
| Adenomatous Polyps | Stem Cell Exhaustion | Individual adenomatous crypts were clonal for mtDNA mutations and contained both mucin-secreting and neuroendocrine cells, demonstrating that the crypt contained a multipotent stem cell. | 23766371 |
| Adenoma, Neoplasms | Stem Cell Exhaustion | Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution. | 23766371 |
| Adenoma of large intestine | Stem Cell Exhaustion | Here we identify multipotential stem cells within human colorectal adenomas and use methylation patterns of nonexpressed genes to characterize clonal evolution. | 23766371 |
| Neoplasms, Adenomatous Polyps | Stem Cell Exhaustion | Adenomatous crypts within human tumors contain actively dividing stem cells. | 23766371 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Moreover, they provide a first example that functional variation in a prospective cancer stem cell marker can be associated with disease risk for the corresponding malignancy. | 23770371 |
| Lymphoma, Follicular, Lymphoma | Stem Cell Exhaustion | The outcome of reduced intensity allogeneic stem cell transplantation and autologous stem cell transplantation when performed as a first transplant strategy in relapsed follicular lymphoma: an analysis from the Lymphoma Working Party of the EBMT. | 23771004 |
| Neoplasms, Hollings Cancer Center | Stem Cell Exhaustion | We performed immunohistochemical staining for uptake transporter of gadoxetic acid: organic anion transporter polypeptides (OATP8); tumor markers: alpha-fetoprotein (AFP) and protein induced by vitamin K absence or antagonist II (PIVKA-II); hepatic stem cell markers: epithelial cell adhesion molecule (EpCAM), cytokeratin 19 (CK19), and neural cell adhesion molecule (NCAM); biliary marker: CK7; hepatocyte marker: hepatocyte paraffin 1 (HepPar1); markers of HCC differentiation: glypican-3; signaling: beta-catenin, and the respective grade was semiquantitatively determined. | 23771695 |
| Hollings Cancer Center | Stem Cell Exhaustion | Hyperintense HCC expressed OATP8 and showed a feature of mature hepatocytes with a weak expression of stem cell characteristics immunohistochemically. | 23771695 |
| Diabetes | Stem Cell Exhaustion | We demonstrated that expression of miR-21 was elevated in circulating endothelial progenitor cells from diabetes patients. | 23771797 |
| EBV-Related Lymphoproliferative Disorder | Stem Cell Exhaustion | Response to rituximab-based therapy and risk factor analysis in Epstein Barr Virus-related lymphoproliferative disorder after hematopoietic stem cell transplant in children and adults: a study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation. | 23771985 |
| Post-transplant lymphoproliferative disorder | Stem Cell Exhaustion | The objective of this analysis was to investigate prognostic factors that influence the outcome of Epstein-Barr virus (EBV)-related posttransplant lymphoproliferative disorder (PTLD) after a rituximab-based treatment in the allogeneic hematopoietic stem cell transplant (HSCT) setting. | 23771985 |
| Dyserythropoiesis | Stem Cell Exhaustion | Iron-overload-related dyserythropoiesis and reactive oxygen species (ROS)-related damage to hematopoietic stem cell (HSC) function are major setbacks in treatment for such disorders. | 23772810 |
| Wiskott-Aldrich Syndrome, Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Successful allogeneic hemopoietic stem cell transplantation in a case of Wiskott-Aldrich syndrome and non-Hodgkin lymphoma. | 23773507 |
| Ulcer, Arteriopathic disease | Stem Cell Exhaustion | Moreover, the transplantation of autologous stem cells extracted with Celution may represent a valuable method for the treatment of chronic ulcers in lower limbs of arteriopathic patients. | 23773718 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Cytarabine, Ki-67, and SOX11 in patients with mantle cell lymphoma receiving rituximab-containing autologous stem cell transplantation during first remission. | 23775587 |
| Medial collateral ligament, Mantle cell lymphoma | Stem Cell Exhaustion | In the current study, the authors report the results of 39 patients with mantle cell lymphoma (MCL) who were treated with chemotherapy and high-dose rituximab-containing autologous stem cell transplantation (ASCT) during their first disease remission. | 23775587 |
| Medial collateral ligament | Stem Cell Exhaustion | Administering ASCT with rituximab during stem cell collection and immediately after transplantation may induce a continuous long-term disease remission in patients with MCL with a Ki-67 level of <= 30%. | 23775587 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cell (CSC)-associated assays, including expression of self-renewal and CSC marker genes, proliferation, differentiation, spheroid formation, chemotherapy resistance, and tumorigenicity were then conducted between SP and non-SP (NSP) LSCCs. | 23776540 |
| Graft-vs-Host Disease, Hematologic Neoplasms | Stem Cell Exhaustion | CD8+ T cell-depleted (TCD) donor lymphocyte infusion (DLI) after TCD allogeneic hematopoietic stem cell transplantation (alloSCT) has been associated with a reduced risk of graft-versus-host disease (GVHD) while preserving conversion to donor hematopoiesis and antitumor immunity, providing a rationale for exploring CD4+ T cell-based immunotherapy for hematologic malignancies. | 23777765 |
| Colorectal Carcinoma, Specialty Type - cancer, Secondary Neoplasm, Cytogenetic Complete Response | Stem Cell Exhaustion | Colorectal cancer (CRC) stem cells or tumor-initiating cells (Co-TIC) are implicated in both cancer recurrence and extranodal metastasis. | 23777983 |
| Seizures | Stem Cell Exhaustion | Multiple hippocampal transection (MHT) is a new surgical procedure which disrupts seizure propagation within the hippocampus without impairing verbal memory or the loss of stem cells. | 23778156 |
| Acute myocardial infarction, Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Effects of ACE inhibition on endothelial progenitor cell mobilization and prognosis after acute myocardial infarction in type 2 diabetic patients. | 23778412 |
| Acute myocardial infarction | Stem Cell Exhaustion | We aimed to assess the chemotactic response of endothelial progenitor cells to angiotensin-converting enzyme inhibitors in T2DM patients after acute myocardial infarction, as well as the associated prognosis. | 23778412 |
| Opportunistic Infections, Gastrointestinal mucositis | Stem Cell Exhaustion | Oral mucositis is a complication frequently associated with hematopoietic stem cell transplantation, decreasing a patient's quality of life and increasing the occurrence of opportunistic infections. | 23778491 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | The purpose of this study was to determine the incidence and severity of oral mucositis and to assess the correlation of this disease with the oral health of an individual at the time of hematopoietic stem cell transplantation. | 23778491 |
| Mucositis following radiation therapy | Stem Cell Exhaustion | The incidence of ulcerative mucositis was highest from days +6 to +10 and from days +11 to +15 in the patients who underwent autologous and allogeneic hematopoietic stem cell transplantation, respectively. | 23778491 |
| Dental Plaque, Stomatitis | Stem Cell Exhaustion | The data, including the dental plaque and periodontal status data, showed that these oral health factors were predictive of the incidence and severity of oral mucositis in a cohort of patients with similar conditioning regimens before hematopoietic stem cell transplantation. | 23778491 |
| Specialty Type - cancer, Primary malignant neoplasm | Stem Cell Exhaustion | The present study investigated whether the expression of CD44 variant 9 (CD44v9), a functional cancer stem cell marker, in the primary gastric cancer tissue represents an indicator of recurrence. | 23778530 |
| Neoplasms | Stem Cell Exhaustion | Sustainable complete remission in recurrence yolk sac tumor patient treated with tandem high-dose chemotherapy and autologous stem cell. | 23781595 |
| Post-transplant lymphoproliferative disorder, Lymphoproliferative Disorders | Stem Cell Exhaustion | Monitoring of Epstein-Barr virus (EBV) load and pre-emptive rituximab is an appropriate approach to prevent post-transplant lymphoproliferative disease (PTLD) occurring after hematopoietic stem cell transplantation (HSCT). | 23781897 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Allogeneic stem cell transplant for adults with myelodysplastic syndromes: relevance of pre-transplant disease status. | 23781926 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | The aim of the present study was to investigate the outcome of 94 adult patients with myelodysplasia (MDS) who received an allogeneic stem cell transplant between January 1995 and September 2010 in two Italian hematology centers. | 23781926 |
| Specialty Type - cancer | Stem Cell Exhaustion | CK5+ / CK20- cells, a phenotype of cancer stem/progenitor cells, represented a very small population (1.9%) and showed a low proliferation activity. | 23782333 |
| Therapy-Related Leukemia, Hypophosphatasia | Stem Cell Exhaustion | Therapy-related Ph+ leukemia after both bone marrow and mesenchymal stem cell transplantation for hypophosphatasia. | 23782379 |
| Colorectal Carcinoma | Stem Cell Exhaustion | The leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) is an adult intestinal stem cell marker frequently detected in human colorectal cancers (CRCs). | 23784051 |
| Traumatic AND/OR non-traumatic injury | Stem Cell Exhaustion | A 9-year-old boy presented with unilateral, total limbal stem cell deficiency (LSCD) complicated by the presence of a large fibro-vascular ocular surface mass lesion secondary to accidental lime injury. | 23784762 |
| Fungal infection of lung | Stem Cell Exhaustion | Aerosolized amphotericin B lipid complex as adjunctive treatment for fungal lung infection in patients with cancer-related immunosuppression and recipients of hematopoietic stem cell transplantation. | 23784915 |
| Lung Diseases, Fungal, Toxic effect, Specialty Type - cancer | Stem Cell Exhaustion | Treatment with aeABLC was tolerated without serious toxicity and may be considered in the setting of severe immunosuppression, cancer, and/or hematopoietic stem cell transplantation in patients with difficult-to-treat fungal lung disease. | 23784915 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Being relatively resistant to conventional treatments, breast cancer stem cells (CSCs) have been postulated as a possible cause of disease recurrence after treatment. | 23787917 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | The combined use of transmyocardial laser revascularisation and intramyocardial injection of bone-marrow derived stem cells in patients with end-stage coronary artery disease: one year follow-up. | 23788089 |
| Inflammation | Stem Cell Exhaustion | Angiogenesis may be induced by intramyocardial injection of autologous bone marrow stem cells, intensified by inflammation around channels performed by laser. | 23788089 |
| Angina Pectoris | Stem Cell Exhaustion | To assess the effect of a combined treatment consisting of transmyocardial laser revascularisation (TLMR) and intramyocardial injection of bone-marrow derived stem cells (bone marrow laser revascularisation, BMLR) in patients with refractory angina one year after the procedure. | 23788089 |
| Cytomegalovirus Retinitis, Multiple Myeloma | Stem Cell Exhaustion | Here, we describe 2 cases of CMV retinitis in myeloma patients with progressive disease, following autologous stem cell transplantation and immunomodulatory therapy for myeloma. | 23790037 |
| Graft-vs-Host Disease, Opportunistic Infections | Stem Cell Exhaustion | The efficacy of hematopoietic stem cell transplantation (HSCT) is greatly hampered by graft-versus-host disease (GVHD) and opportunistic infection; the gastrointestinal tract is one of the main target organs involved by GVHD and opportunistic infectious agents. | 23791208 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Outcomes in patients age 70 or older undergoing allogeneic hematopoietic stem cell transplantation for hematologic malignancies. | 23791626 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (HSCT) can achieve durable remissions in a number of patients with advanced hematologic malignancies. | 23791626 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Comparison of glioma stem cells to neural stem cells from the adult human brain identifies dysregulated Wnt- signaling and a fingerprint associated with clinical outcome. | 23791939 |
| Adult Glioblastoma | Stem Cell Exhaustion | We have performed the first genome-wide analysis that directly relates the gene expression profile of nine enriched populations of glioblastoma stem cells (GSCs) to five identically isolated and cultivated populations of stem cells from the normal adult human brain. | 23791939 |
| Specialty Type - cancer | Stem Cell Exhaustion | A subset of these pathways has previously been identified in leukemic stem cells, suggesting that cancer stem cells of different origin may have common features. | 23791939 |
| Engraftment syndrome | Stem Cell Exhaustion | Low levels of interleukin-1 receptor antagonist (IL-1RA) predict engraftment syndrome after autologous stem cell transplantation in POEMS syndrome and other plasma cell neoplasms. | 23792270 |
| POEMS Syndrome, Engraftment syndrome | Stem Cell Exhaustion | Patients with POEMS are known to have a high incidence of engraftment syndrome after autologous stem cell transplantation. | 23792270 |
| Neoplasms | Stem Cell Exhaustion | Biological experiments in GSC cells validated the bioinformatics analysis results and revealed that LGR5 regulated the tumor sphere formation capacity, an important stem cell property for GSCs. | 23793848 |
| Hepatitis E, Pathogenesis of HIV Opportunistic Infection | Stem Cell Exhaustion | Hepatitis E virus: an underestimated opportunistic pathogen in recipients of allogeneic hematopoietic stem cell transplantation. | 23794068 |
| melanoma, Specialty Type - cancer | Stem Cell Exhaustion | We investigate the unknown tumor-killing activity of cytokine-induced killer (CIK) cells against autologous metastatic melanoma and the elusive subset of putative cancer stem cells (mCSC). | 23794732 |
| Lymphomatoid Granulomatosis | Stem Cell Exhaustion | Long-term remission after multiple relapses in an elderly patient with lymphomatoid granulomatosis after rituximab and high-dose cytarabine chemotherapy without stem-cell transplantation. | 23796993 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Role of reduced-intensity conditioning allogeneic hematopoietic stem-cell transplantation in older patients with de novo myelodysplastic syndromes: an international collaborative decision analysis. | 23797000 |
| Blood Vessel | Stem Cell Exhaustion | Although circulating endothelial progenitor cells (EPCs) preserve endothelial integrity, inflammatory endothelial cells (IECs) detach from sites of injury and represent markers of vascular damage. | 23798347 |
| Epithelial ovarian cancer, Secondary Neoplasm | Stem Cell Exhaustion | High levels of circulating CD34+/VEGFR3+ lymphatic/vascular endothelial progenitor cells is correlated with lymph node metastasis in patients with epithelial ovarian cancer. | 23803010 |
| Malignant neoplasm of ovary, Secondary Neoplasm | Stem Cell Exhaustion | To clarify the role of CD34 and vascular endothelial growth factor receptor-3-positive (CD34+/VEGFR3+) lymphatic/vascular endothelial progenitor cells (LVEPC) in patients with lymph node metastasis and epithelial ovarian cancer progression, the levels of circulating CD34+/VEGFR3+ LVEPC in epithelial ovarian cancer patients were detected. | 23803010 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | High-dose chemotherapy (HDT) supported by autologous stem cell transplantation (ASCT) has long been one of the standards of care for younger patients with multiple myeloma (MM). | 23804501 |
| Multiple Myeloma | Stem Cell Exhaustion | Hematopoietic progenitor cell mobilization using low-dose cyclophosphamide and granulocyte colony-stimulating factor for multiple myeloma. | 23804501 |
| Clostridium difficile colitis, Hematologic Neoplasms | Stem Cell Exhaustion | The primary objective was to assess the incidence and severity of C. difficile infection in patients with hematologic malignancies, including those undergoing hematopoietic stem cell transplant for a hematologic condition. | 23804627 |
| Clostridium difficile colitis, Hematologic Neoplasms | Stem Cell Exhaustion | This study is the first analysis conducted, which directly compares outcomes of C. difficile infection after therapy with metronidazole, vancomycin, or combination therapy exclusively in patients with hematologic malignancies, including those undergoing hematopoietic stem cell transplant for a hematologic condition. | 23804627 |
| Specialty Type - cancer | Stem Cell Exhaustion | This old agent is now a serious anti-cancer drug candidate that selectively inhibits the growth of cancer stem cells. | 23805285 |
| Congestive heart failure, Inflammation | Stem Cell Exhaustion | To determine the effects of physical training on circulating endothelial progenitor cells (EPCs), angiogenesis (angiogenin, angiopoietin-1 and -2, VEGF, Tie-2, SDF-1a) and inflammation (IL-6, CRP), we compared data obtained from 11 CHF pts before and after 3 months aerobic exercise training, to those from 10 non trained CHF pts (CHF-C group, age 64 + 2 years, NYHA 2). | 23805979 |
| Engraftment syndrome, Multiple Myeloma | Stem Cell Exhaustion | Divergent effects of novel immunomodulatory agents and cyclophosphamide on the risk of engraftment syndrome after autologous peripheral blood stem cell transplantation for multiple myeloma. | 23806770 |
| Engraftment syndrome | Stem Cell Exhaustion | Engraftment syndrome (ES) is an increasingly observed and occasionally fatal complication after autologous peripheral blood stem cell transplantation (PBSCT). | 23806770 |
| Aneuploidy | Stem Cell Exhaustion | Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy. | 23807220 |
| Specialty Type - cancer | Stem Cell Exhaustion | Patient satisfaction with nutrition services amongst cancer patients treated with autologous stem cell transplantation: a comparison of usual and extended care. | 23808817 |
| Specialty Type - cancer | Stem Cell Exhaustion | This study aimed to determine patient satisfaction with clinical nutrition services delivered by an accredited practicing dietitian amongst cancer patients treated with autologous stem cell transplantation that was provided with usual and extended care at 100 days post-transplantation. | 23808817 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer patients treated with autologous stem cell transplantation were satisfied with usual and extended nutrition care. | 23808817 |
| Specialty Type - cancer | Stem Cell Exhaustion | The regenerative effects of fat injections are based on the same hormones, growth factors, and stem cells that stimulate neoplastic angiogenesis and cancer progression in basic research. | 23812610 |
| Lymphoma | Stem Cell Exhaustion | Outcomes of patients with relapsed/refractory diffuse large B-cell lymphoma with progression of lymphoma after autologous stem cell transplantation in the rituximab era. | 23813874 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | Salvage chemotherapy followed by autologous stem cell transplant (ASCT) remains the current standard of care for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) with chemosensitive disease. | 23813874 |
| Infection of bloodstream, Hemopoietic stem cell transplant | Stem Cell Exhaustion | [Bloodstream infections after liver and hematopoietic stem cell transplantation]. | 23814965 |
| Behavioral Symptoms Index Composite Score (BASC-2), Infection of bloodstream | Stem Cell Exhaustion | The aim of this retrospective study was to evaluate and compare the incidence, timing and etiology of bloodstream infections (BSIs) in patients treated with liver-(LT) or hematopoietic stem cell transplantation (HSCT) in a single institution. | 23814965 |
| Lymphoma | Stem Cell Exhaustion | Comparision of benefits of early, delayed, and no administration of G-CSF after autologous peripheral blood stem cell transplantation in lymphoma patients. | 23817440 |
| Lymphoma | Stem Cell Exhaustion | Autologous peripheral blood stem cell transplantation (PBSCT) is commonly used in the treatment of lymphoma patients. | 23817440 |
| Kidney Failure, Rheumatoid Arthritis | Stem Cell Exhaustion | Thymic insufficiency in RA is not attributable to an inadequate supply of progenitor cells to the thymus. | 23818218 |
| Osteopenia | Stem Cell Exhaustion | Reversing bone loss by directing mesenchymal stem cells to bone. | 23818248 |
| Hodgkin Disease | Stem Cell Exhaustion | Early thymus and activation-regulated chemokine (TARC) reduction and response following panobinostat treatment in patients with relapsed/refractory Hodgkin lymphoma following autologous stem cell transplant. | 23822537 |
| Chronic graft-versus-host disease | Stem Cell Exhaustion | National Institutes of Health classification for chronic graft-versus-host disease predicts outcome of allo-hematopoietic stem cell transplant after fludarabine-busulfan-antithymocyte globulin conditioning regimen. | 23822538 |
| Stable chronic Graft vs Host Disease, Hematologic Neoplasms | Stem Cell Exhaustion | We retrospectively reclassified cGvHD with NIH criteria in a monocentric cohort of 130 consecutive adult patients with hematological malignancies presenting cGvHD after receiving allo-hematopoietic stem cell transplant (HSCT) with a fludarabine-busulfan-antithymocyte globulin (ATG) conditioning regimen, among 313 consecutive HSCT recipients. | 23822538 |
| Diabetes Mellitus, Insulin-Dependent | Stem Cell Exhaustion | Amniotic stem cell transplantation therapy for type 1 diabetes: a case report. | 23828649 |
| Diabetes Mellitus, Insulin-Dependent | Stem Cell Exhaustion | A 26-year-old man with type 1 diabetes was treated with stem cells isolated from his neonatal son's amniotic membrane, collected at birth (2 x 10(7) cells). | 23828649 |
| B-Cell Lymphomas, Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | Patients with diffuse large B cell lymphoma (DLBCL) who are not candidates for or recur after autologous stem cell transplant have a poor overall prognosis. | 23829878 |
| Chronic Obstructive Airway Disease, Idiopathic Pulmonary Fibrosis | Stem Cell Exhaustion | According to recently proposed pathogenic models in COPD and IPF, premature cellular senescence likely affects distinct progenitors cells (mesenchymal stem cells in COPD, alveolar epithelial precursors in IPF), leading to stem cell exhaustion. | 23831269 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell (HSC) transplantation is a curative treatment for many hematologic malignancies for which umbilical cord blood (UCB) represents an alternative source of HSCs. | 23831606 |
| B-Cell Lymphomas, Malignant Neoplasms | Stem Cell Exhaustion | Clonal analysis of the hematopoetic stem cell compartment suggests that TET2 mutations can be early events in hematologic cancers and recent investigations have shown TET2 mutations in diffuse large B-cell lymphoma. | 23831920 |
| Immunocompromised Host | Stem Cell Exhaustion | To evaluate cell survival and tumorigenicity of human embryonic stem cell-derived retinal pigment epithelium (hESC-RPE) transplantation in immunocompromised nude rats. | 23833067 |
| Aggressive Adult Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Single-agent lenalidomide is active in patients with relapsed or refractory aggressive non-Hodgkin lymphoma who received prior stem cell transplantation. | 23834234 |
| Lymphoma, Non-Hodgkin, Familial, Aggressive Adult Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Patients with aggressive non-Hodgkin lymphoma (NHL) who relapse after autologous stem cell transplantation (ASCT) have a poor prognosis. | 23834234 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | The hypothesis on cancer stem cells assumes the existence of small subpopulation of cells that possess the ability to undergo self-renewal and can give rise to the diversity of differentiated cells that form the tumour. | 23835592 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | It has been accepted that CD44(+)/CD24(-/low) phenotype is one of the features characterizing breast cancer stem cells. | 23835592 |
| Neoplasms | Stem Cell Exhaustion | GBM is a highly heterogeneous tumour and may contain different stem cell populations with different functional properties. | 23836332 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Increasing evidence shows that brain tumours contain the population of stem cells, so-called cancer stem cells (CSCs). | 23836332 |
| Acute Promyelocytic Leukemia | Stem Cell Exhaustion | Role of hematopoietic stem cell transplantation for relapsed acute promyelocytic leukemia: a retrospective analysis of JALSG-APL97. | 23837667 |
| ATRICHIA WITH PAPULAR LESIONS | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (HSCT) during CR2 might be effective, but data on the role of HSCT for APL patients after CR2 are limited in Japan. | 23837667 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Targeting insulin resistance in type 2 diabetes via immune modulation of cord blood-derived multipotent stem cells (CB-SCs) in stem cell educator therapy: phase I/II clinical trial. | 23837842 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Clinical findings indicate that T2D patients achieve improved metabolic control and reduced inflammation markers after receiving Stem Cell Educator therapy. | 23837842 |
| Immune System Diseases | Stem Cell Exhaustion | Mechanistic studies revealed that Stem Cell Educator therapy reverses immune dysfunctions through immune modulation on monocytes and balancing Th1/Th2/Th3 cytokine production. | 23837842 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Clinical data from the current phase 1/phase 2 study demonstrate that Stem Cell Educator therapy is a safe approach that produces lasting improvement in metabolic control for individuals with moderate or severe T2D who receive a single treatment. | 23837842 |
| Acute GVH disease | Stem Cell Exhaustion | Proteomic peptide profiling for preemptive diagnosis of acute graft-versus-host disease after allogeneic stem cell transplantation. | 23842427 |
| Graft-vs-Host Disease, Hematologic Neoplasms, Acute GVH disease | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation is one curative treatment for hematological malignancies, but is compromised by life-threatening complications, such as severe acute graft-versus-host disease (aGvHD). | 23842427 |
| Cartilage Diseases | Stem Cell Exhaustion | Increasing evidence indicates that the secretome of mesenchymal stem cells (MSCs) has therapeutic potential for the treatment of various diseases, including cartilage disorders. | 23843355 |
| Neutropenia | Stem Cell Exhaustion | The results indicated that granulocyte colony stimulating factor (G-CSF) enhanced survival, stimulated recovery from neutropenia, and induced mobilization of hematopoietic progenitor cells. | 23845847 |
| Stem Cell Factor, Childhood Breast Carcinoma, Neoplasms, Mammary Neoplasms, Carcinoma | Stem Cell Exhaustion | Plasma levels of selected hematopoietic cytokines: interleukin 3 ( IL-3), stem cell factor (SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF) and macrophage colony-stimulating factor (M-CSF), and the tumor marker carcinoma antigen 15-3 (CA 15-3) in breast cancer (BC) patients were investigated and compared to control groups: benign breast tumor patients and healthy subjects. | 23846151 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | In patients with MDS, MRD remains the best stem cell source followed by 8 of 8 MUD. | 23847196 |
| T-Cell Lymphoma | Stem Cell Exhaustion | Allogeneic stem cell transplantation with BEAM and alemtuzumab conditioning immediately after remission induction has curative potential in advanced T-cell non-Hodgkin's lymphoma. | 23850653 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Patients with relapsed or refractory advanced T cell non-Hodgkin lymphoma have a dismal prognosis and may not even reach allogeneic hematopoietic stem cell transplantation (HSCT) in adequate condition. | 23850653 |
| Osteolipoma | Stem Cell Exhaustion | Mesenchymal stem cells in adipose tissue that have potential to differentiate into fat, bone, cartilage, and vascular components may be involved in the development of osteolipoma, in which adipose and bone tissues coexist. | 23851795 |
| Lipoma | Stem Cell Exhaustion | Mesenchymal stem cells were collected by collagenase treatment of lipoma tissue, and their potential to differentiate into fat, bone, and cartilage was shown. | 23851795 |
| Osteolipoma | Stem Cell Exhaustion | On the basis of this study, we suggest that lipoma-derived mesenchymal stem cells are the basis of the pathogenesis of osteolipoma. | 23851795 |
| MYELODYSPLASTIC SYNDROME, Multiple Myeloma | Stem Cell Exhaustion | Hematopoietic progenitor cell collection after autologous transplant for multiple myeloma: low platelet count predicts for poor collection and sole use of resulting graft enhances risk of myelodysplasia. | 23852547 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Collection of hematopoietic progenitor cells (HPC) after previous autologous hematopoietic progenitor cell transplant (aHCT) was studied in 221 patients with multiple myeloma (MM). | 23852547 |
| Idiopathic Pulmonary Fibrosis, Chronic lung disease | Stem Cell Exhaustion | Regenerative medicine and particular adult stem cells represent an alternative option with several fruitful therapeutic applications in patients suffering from chronic lung diseases including idiopathic pulmonary fibrosis (IPF). | 23855653 |
| Hollings Cancer Center | Stem Cell Exhaustion | Immunohistochemistry was used to localize phosphorylated c-kit (CD117/stem cell factor) in HCC smooth muscle cells. | 23856589 |
| Aspergillosis | Stem Cell Exhaustion | TLR5 stop codon polymorphism is associated with invasive aspergillosis after allogeneic stem cell transplantation. | 23862689 |
| Aspergillosis | Stem Cell Exhaustion | Single nucleotide polymorphisms (SNPs) have been associated with an increased incidence of invasive aspergillosis (IA) after allogeneic stem cell transplantation (allo-SCT). | 23862689 |
| Multiple Myeloma | Stem Cell Exhaustion | Implications of continued response after autologous stem cell transplantation for multiple myeloma. | 23863899 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Patients undergoing autologous stem cell transplantation (ASCT) for multiple myeloma (MM) undergo disease assessment approximately 100 days later. | 23863899 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | AML patients (n = 14) with a median age of 46 years received 7+3 courses (n = 3) containing cytarabine > or = 1 g/m2/introduction (n = 8) and myeloablative conditioning regimen before hematopoietic stem cell transplantation (n = 3). | 23866600 |
| Colitis | Stem Cell Exhaustion | Antioxidant properties of mesalamine in colitis inhibit phosphoinositide 3-kinase signaling in progenitor cells. | 23867870 |
| Mastocytosis | Stem Cell Exhaustion | Migration of CD117+ progenitor cells from the blood was enhanced toward NGF-b gradient in both mastocytosis and controls. | 23869086 |
| diabetic | Stem Cell Exhaustion | Human immune system development and survival of non-obese diabetic (NOD)-scid IL2rg(null) (NSG) mice engrafted with human thymus and autologous haematopoietic stem cells. | 23869841 |
| Hypoplastic Left Heart Syndrome | Stem Cell Exhaustion | Fetal reprogramming and senescence in hypoplastic left heart syndrome and in human pluripotent stem cells during cardiac differentiation. | 23871585 |
| Hypoxia | Stem Cell Exhaustion | We recapitulated the fetal phenotype by subjecting human pluripotent stem cells to hypoxia during cardiac differentiation. | 23871585 |
| Hypoxia | Stem Cell Exhaustion | The phenotype is recapitulated by subjecting human pluripotent stem cells to hypoxia during cardiac differentiation and rescued by inhibition of TGF-b1. | 23871585 |
| Multiple Myeloma | Stem Cell Exhaustion | A randomized phase II trial of fludarabine/melphalan 100 versus fludarabine/melphalan 140 followed by allogeneic hematopoietic stem cell transplantation for patients with multiple myeloma. | 23872222 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (allo-HCT) is a potentially curative treatment for multiple myeloma (MM); however, because of high treatment-related mortality (TRM), its role is not well defined. | 23872222 |
| Crohn Disease | Stem Cell Exhaustion | Transplantation of peripheral blood stem cells has been successful therapy for small numbers of patients with Crohn's disease (CD), but requires prior myeloconditioning. | 23872668 |
| Malignant Neoplasms | Stem Cell Exhaustion | Controls were matched for timing relative to transplant, malignancy, and stem cell source. | 23872740 |
| Membranoproliferative Glomerulonephritis, Type II | Stem Cell Exhaustion | The patient experienced marked improvement of muscle strength after autologous stem cell transplantation and treatment with bortezomib, a therapy that is known to be effective in light chain deposition disease. | 23873431 |
| Medial collateral ligament, Mantle cell lymphoma | Stem Cell Exhaustion | The management of patients with mantle cell lymphoma (MCL) not eligible for stem cell transplantation in relapse after receiving standard approaches remains challenging, and the search for active and tolerable regimens is still warranted. | 23873598 |
| Anemia | Stem Cell Exhaustion | Efforts to understand the pathophysiology of anemia in this population, especially the one third of patients with "unexplained" anemia, have focused on the potential contributions of inflammatory pathways, erythropoietin resistance, and changes in hematopoietic stem cells to the age-dependent decrease in red cell mass. | 23874029 |
| Specialty Type - cancer, Krukenberg Tumor | Stem Cell Exhaustion | Furthermore, we examined the expression of some cancer stem cells (CSCs) markers or related molecules in 64 ovarian metastases specimens and analyzed the correlation between these molecules and patients' survival. | 23874550 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Peri-procedural tight glycemic control during early percutaneous coronary intervention up-regulates endothelial progenitor cell level and differentiation during acute ST-elevation myocardial infarction: effects on myocardial salvage. | 23876463 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | We examined the effects of peri-procedural intensive glycemic control during early percutaneous coronary intervention (PCI) on the number and differentiation of endothelial progenitor cells (EPCs) and myocardial salvage (MS) in hyperglycemic patients with first ST-elevation myocardial infarction (STEMI). | 23876463 |
| Multiple Myeloma | Stem Cell Exhaustion | Combination of high-dose melphalan and bortezomib as conditioning regimen for autologous peripheral blood stem cell transplantation in multiple myeloma. | 23877150 |
| Toxic effect | Stem Cell Exhaustion | Engraftment of autologous peripheral blood stem cells and regimen-related toxicities (RRT) were comparable among the HDM and Bor-HDM groups. | 23877150 |
| Non-Small Cell Lung Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Baseline and post-surgery endothelial progenitor cell levels in patients with early-stage non-small-cell lung carcinoma: impact on cancer recurrence and survival. | 23882070 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Results of clonogeneic progenitor cell assays from 52 patients with newly diagnosed CML were correlated with disease characteristics at presentation and molecular response to imatinib. | 23883175 |
| Neoplasms, Intracranial | Stem Cell Exhaustion | Neural stem cell sparing by linac based intensity modulated stereotactic radiotherapy in intracranial tumors. | 23883368 |
| Neoplasms, Intracranial | Stem Cell Exhaustion | The feasibility of neural stem cell niches sparing with sophisticated linac based inverse IMSRT with 7 beamlets in an unselected cohort of intracranial tumors in relation to topographic situation has been demonstrated. | 23883368 |
| Imprinting (Psychology) | Stem Cell Exhaustion | It can be hypothesized that skeletal muscle microenvironmental changes induced by endurance training lead to metabolic imprinting on myogenic progenitor cells. | 23884778 |
| Radiation Pneumonitis | Stem Cell Exhaustion | Variations of circulating endothelial progenitor cells and transforming growth factor-beta-1 (TGF-b1) during thoracic radiotherapy are predictive for radiation pneumonitis. | 23885707 |
| Retinitis Pigmentosa, Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | This study investigated the variations of circulating endothelial progenitor cells (EPCs) and transforming growth factor-beta-1 (TGF-b1) during three-dimensional conformal radiation therapy (3D-CRT) in patients with non-small-cell lung cancer (NSCLC) and analyzed the correlation between these variations with the occurrence of RP. | 23885707 |
| Neoplasms | Stem Cell Exhaustion | For each patient, frozen normal and tumor tissue was used for the comparison of gene expression levels of two putative cancer stem cell markers, CDX2 and Oct4, using real-time PCR (rtPCR). | 23887079 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Glioma spheroids obtained via ultrasonic aspiration are viable and express stem cell markers: a new tissue resource for glioma research. | 23887192 |
| Mycoses, Aspergillosis | Stem Cell Exhaustion | Posaconazole is recommended for prophylaxis of fungal infections and for salvage therapy of invasive aspergillosis after stem cell transplantation. | 23890126 |
| Illness (finding), Respiratory Tract Infections | Stem Cell Exhaustion | Human rhinoviruses (HRVs) are a common cause of upper respiratory infection (URI) in hematopoietic stem cell transplant (HSCT) recipients; yet, their role in lower respiratory illness is not well understood. | 23890179 |
| Aspergillosis | Stem Cell Exhaustion | Increased susceptibility for aspergillosis and post-transplant immune deficiency in patients with gene variants of TLR4 after stem cell transplantation. | 23890253 |
| Opportunistic fungal infection, Immunocompromised Host | Stem Cell Exhaustion | In allogeneic hematopoietic stem cell transplantation (HSCT), the frequent opportunistic fungal infections remain an important cause of mortality and morbidity in these highly immunocompromised patients. | 23890253 |
| Influenza due to Influenza A virus subtype H1N1 | Stem Cell Exhaustion | A multicenter evaluation of pandemic influenza A/H1N1 in hematopoietic stem cell transplant recipients. | 23890293 |
| Viral respiratory infection | Stem Cell Exhaustion | Hematopoietic stem cell transplant (HSCT) recipients have increased morbidity from respiratory viral infections. | 23890293 |
| Infection | Stem Cell Exhaustion | Treatment with allogeneic virus-specific cytotoxic T lymphocytes from seropositive third-party donors may be a feasible therapeutic option for infections following cord-blood stem cell transplantation or hematopoietic stem cell transplantation from virus-seronegative donors. | 23891747 |
| Primary, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | In order to evaluate the significance of the GABARAPs in the pathogenesis of acute myeloid leukemia (AML), we compared their expression in primary AML patient samples, CD34(+) progenitor cells and in granulocytes from healthy donors. | 23891751 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | We report a patient with entrapment syndromes of multiple nerves associated with chronic graft-versus-host-disease (GVHD) after allogeneic hematopoietic stem cell transplantation. | 23893492 |
| Allogeneic Hematopoietic Stem Cell Transplantation, Herpes Simplex Infections | Stem Cell Exhaustion | Low-dose acyclovir prophylaxis for the prevention of herpes simplex virus disease after allogeneic hematopoietic stem cell transplantation. | 23895431 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents. | 23896410 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Importantly, dasatinib markedly increases the elimination of AML stem cells capable of engrafting immunodeficient mice by chemotherapeutic agents. | 23896410 |
| Palmar-plantar erythrodysesthesia syndrome, leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | In vivo dasatinib treatment enhances chemotherapy-induced targeting of primary murine AML stem cells capable of regenerating leukemia in secondary recipients. | 23896410 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Combined treatment using dasatinib and chemotherapy provides a novel approach to increasing p53 activity and enhancing targeting of AML stem cells. | 23896410 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Treatment with the SFK and c-KIT inhibitor dasatinib selectively inhibits human AML stem/progenitor cell growth in vitro. | 23896410 |
| FGR gene, HCK gene, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We show here that the SFKs LYN, HCK, or FGR are overexpressed and activated in AML progenitor cells. | 23896410 |
| Acute leukemia | Stem Cell Exhaustion | Predictive factors for rapid neutrophil and platelet engraftment after allogenic peripheral blood stem cell transplantation in patients with acute leukemia. | 23896629 |
| Acute leukemia | Stem Cell Exhaustion | The aim of this study was to investigate predictive factors for rapid engraftment after allogeneic peripheral blood stem cell transplantation (alloPBSCT) in patients with acute leukemia. | 23896629 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | Dysfunction of endothelial progenitor cells from smokers and chronic obstructive pulmonary disease patients due to increased DNA damage and senescence. | 23897750 |
| Multiple Myeloma | Stem Cell Exhaustion | Bortezomib-based versus nonbortezomib-based induction treatment before autologous stem-cell transplantation in patients with previously untreated multiple myeloma: a meta-analysis of phase III randomized, controlled trials. | 23897961 |
| Multiple Myeloma | Stem Cell Exhaustion | Varicella-zoster virus-associated fulminant hepatitis following allogeneic hematopoietic stem cell transplantation for multiple myeloma. | 23903507 |
| herpesvirus 3, human, Communicable Diseases | Stem Cell Exhaustion | Disseminated visceral varicella-zoster virus (VZV) infection rarely occurs in recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 23903507 |
| Specialty Type - cancer | Stem Cell Exhaustion | The discovery of specific membrane-associated cancer stem cell (CSC) markers is crucial for the development of novel therapeutic strategies to target these CSCs. | 23903875 |
| Bacteremia, Gastrointestinal mucositis, Neutropenia | Stem Cell Exhaustion | This case underscores that mostly nonpathogenic N. mucosa can cause bacteremia in neutropenic patients who developed mucositis after hematopoietic stem cell transplantation. | 23905778 |
| Neoplasms | Stem Cell Exhaustion | Efficacious therapy requires the removal of stem-cell like cells, these cells drive tumor progression because of their ability to self-renew and differentiate. | 23907517 |
| Lymphoma, Non-Hodgkin, Familial | Stem Cell Exhaustion | The efficacy and safety of plerixafor + G-CSF in enhancing hematopoietic stem cell mobilization and collection has been demonstrated in two phase III studies involving patients with NHL or MM. | 23907769 |
| Lymphoma, Non-Hodgkin, Familial | Stem Cell Exhaustion | The proportion of older patients who achieved target stem cell yields was significantly higher in the plerixafor group than in placebo group (NHL: 50.9 vs. 25.4%, P < 0.001; MM: 69.6 vs. 23.7%, P < 0.001). | 23907769 |
| Lymphoma, Non-Hodgkin, Multiple Myeloma | Stem Cell Exhaustion | Safety and efficacy of upfront plerixafor + G-CSF versus placebo + G-CSF for mobilization of CD34(+) hematopoietic progenitor cells in patients >=60 and <60 years of age with non-Hodgkin's lymphoma or multiple myeloma. | 23907769 |
| HIV, Malignant Neoplasms | Stem Cell Exhaustion | In a randomized, double-blind, placebo-controlled, multicenter study, 4 doses ZVHT or placebo were administered approximately 30 days apart to adults with either solid tumor malignancy (STM); hematologic malignancy (HM); human immunodeficiency virus (HIV) with CD4(+) <=200; autologous hematopoietic stem-cell transplant (HCT) or allogeneic-HCT recipients. | 23908479 |
| Multiple Myeloma | Stem Cell Exhaustion | Fifteen years of single center experience with stem cell transplantation for multiple myeloma: a retrospective analysis. | 23909048 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Autologous stem cell transplantation (ASCT) became standard of care for patients with multiple myeloma (MM) under the age of 65 years. | 23909048 |
| Central neuroblastoma | Stem Cell Exhaustion | He required intensive chemotherapy with polypharmacy, followed by cord blood stem cell transplantation to treat the neuroblastoma. | 23910817 |
| Addisonian crisis | Stem Cell Exhaustion | Continuous hydrocortisone therapy is feasible for preventing adrenal crisis and this report may provide an effective management for hydrocortisone replacement in 21-hydroxylase-deficient patients undergoing chemotherapy and hematopoietic stem cell transplantation. | 23910817 |
| Specialty Type - cancer | Stem Cell Exhaustion | Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. | 23911321 |
| Specialty Type - cancer | Stem Cell Exhaustion | Strikingly, we discovered a critical function of Skp2 in positively regulating cancer stem cell populations and self-renewal ability through genetic and pharmacological approaches. | 23911321 |
| Specialty Type - cancer | Stem Cell Exhaustion | Our study thus provides pharmacological evidence that Skp2 is a promising target for restricting cancer stem cell and cancer progression. | 23911321 |
| SERPINB3 wt Allele, Specialty Type - cancer | Stem Cell Exhaustion | The objective of this study to determine protein expression of cancer stem cell marker CD133 in tissue samples of patients with OLP and evaluate the correlation between CD133 expression and the risk of progression to OSCC. | 23911820 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Patients with advanced hematologic malignancies remain at risk for relapse following reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 23912587 |
| Stable chronic Graft vs Host Disease | Stem Cell Exhaustion | On multivariate analysis, use of BM as stem cell source was associated with better OS and EFS, and less acute and cGVHD; young age was associated with better EFS and lower risk of graft failure. | 23912664 |
| Hair follicle structure | Stem Cell Exhaustion | The leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5), also known as Gpr49, has been identified as a marker of crypt basal columnar stem cells along the gastrointestinal tract and of bulge stem cells in the hair follicle. | 23915911 |
| Specialty Type - cancer | Stem Cell Exhaustion | The enzyme aldehyde dehydrogenase 1 (ALDH1) has been reported as a biomarker for identifying cancer stem cells. | 23916993 |
| Leukoencephalopathy, Progressive Multifocal, Chronic Lymphocytic Leukemia, Leukoencephalopathy | Stem Cell Exhaustion | We describe a case of progressive multifocal leucoencephalopathy (PML) in a 39-year-old patient diagnosed with chronic lymphocytic leukaemia (CLL) who underwent two allogenic matched-sibling stem cell transplantations. | 23917368 |
| Neurologic Symptoms, Virus Diseases | Stem Cell Exhaustion | However, after the second stem cell transplantation, new neurological symptoms began and a reactivation of the JC virus infection was detected. | 23917368 |
| Pulmonary Embolism | Stem Cell Exhaustion | Familial occurrence of pulmonary embolism after intravenous, adipose tissue-derived stem cell therapy. | 23918585 |
| Disk, Herniated | Stem Cell Exhaustion | He had received intravenous autologous adipose tissue-derived stem cell therapy for cervical herniated intervertebral disc three times (one, two, and three months prior to the visit). | 23918585 |
| Acute leukemia | Stem Cell Exhaustion | Second allograft for hematologic relapse of acute leukemia after first allogeneic stem-cell transplantation from related and unrelated donors: the role of donor change. | 23918951 |
| Acute leukemia | Stem Cell Exhaustion | To evaluate the role of a second allogeneic hematopoietic stem-cell transplantation (HSCT2) given for relapsed acute leukemia (AL) after related or unrelated first hematopoietic stem-cell transplantation (HSCT1) and to analyze the role of donor change for HSCT2 in both settings. | 23918951 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Stem cell transplantation for follicular lymphoma relapsed/refractory after prior rituximab: a comprehensive analysis from the NCCN lymphoma outcomes project. | 23921646 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Stem cell transplant (SCT)-related outcomes and prognostication for relapsed/refractory follicular lymphoma (FL) are not well-defined in the post-rituximab era. | 23921646 |
| Specialty Type - cancer | Stem Cell Exhaustion | The mRNA and protein levels of Pyk2 or cancer stem cell markers (ALDH1a1, ABCG2 and Bmi-1) were either examined by reverse transcription-PCR or western blotting. | 23922106 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Cost-effectiveness of hematopoietic stem cell mobilization strategies including plerixafor in multiple myeloma and lymphoma patients. | 23922227 |
| Mesenchymal Stem Cells, Thrombocytopenia due to platelet alloimmunization | Stem Cell Exhaustion | Thalidomide corrects impaired mesenchymal stem cell function in inducing tolerogenic DCs in patients with immune thrombocytopenia. | 23926306 |
| Inosine Triphosphate, Decreased platelet count, Autoimmune Disorder, CTCAE | Stem Cell Exhaustion | Immune thrombocytopenia (ITP) is an autoimmune disorder in which impaired mesenchymal stem cells (MSCs) are potentially involved. | 23926306 |
| Congestive heart failure | Stem Cell Exhaustion | This cohort formed the sampling frame for selecting controls (without CHF) matched on: age, race/ethnicity, cumulative anthracycline exposure, stem cell source (allogeneic, autologous), and length of follow-up. | 23927520 |
| Osteoporotic Fractures | Stem Cell Exhaustion | Cyclic tensile strain enhances osteogenesis and angiogenesis in mesenchymal stem cells from osteoporotic donors. | 23927731 |
| Acute leukemia | Stem Cell Exhaustion | Feasibility of clofarabine cytoreduction followed by haploidentical hematopoietic stem cell transplantation in patients with relapsed or refractory advanced acute leukemia. | 23928857 |
| Acute leukemia | Stem Cell Exhaustion | This retrospective study was performed to evaluate the feasibility and anti-leukemic activity of a sequential therapy using clofarabine for cytoreduction followed by conditioning for haploidentical hematopoietic stem cell transplantation (HSCT) in patients with non-remission acute leukemia. | 23928857 |
| Specialty Type - cancer | Stem Cell Exhaustion | Embryogenesis, morphogens and cancer stem cells: putting the puzzle together. | 23932050 |
| Specialty Type - cancer, Carcinogenesis | Stem Cell Exhaustion | This paper describes a model which puts together three key elements of cancer theory: the analogies between embryogenesis and carcinogenesis, the role played in both processes by morphogens and related pathways, and the recently emerged paradigm of cancer stem cells. | 23932050 |
| Specialty Type - cancer | Stem Cell Exhaustion | Our hypothesis also suggests that cancer stem cells can stay dormant until they are activated in a process that resembles activation of stem cells during tissue repair or at a specific time during development. | 23932050 |
| PAFAH1B1 wt Allele, Multiple Myeloma | Stem Cell Exhaustion | Prevalence of iron overload vs iron deficiency in multiple myeloma: resembling or different from MDS--and stem cell transplant (SCT)--patients? | 23932905 |
| Hematopoietic stem cells, Paroxysmal nocturnal hemoglobinuria, Hemolysis (biological function), Hemoglobinuria, CTCAE 3.0 | Stem Cell Exhaustion | Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, progressive hematopoietic stem cell disorder characterized by chronic complement-mediated hemolysis leading to life-threatening complications and early mortality. | 23934275 |
| Malignant Neoplasms | Stem Cell Exhaustion | Alternative donor hematopoietic stem cell transplantation for mature lymphoid malignancies after reduced-intensity conditioning regimen: similar outcomes with umbilical cord blood and unrelated donor peripheral blood. | 23935024 |
| Chronic graft-versus-host disease | Stem Cell Exhaustion | In a multivariate analysis, no differences were observed in the outcomes between the two stem cell sources except for a higher risk of neutrophil engraftment (hazard ratio=2.12; P<0.0001) and chronic graft-versus-host disease (hazard ratio 2.10; P=0.0002) after matched unrelated donor transplant. | 23935024 |
| Malignant Neoplasms | Stem Cell Exhaustion | We studied 645 adult patients with mature lymphoid malignancies who received an allogeneic unrelated donor transplant using umbilical cord blood (n=104) or mobilized peripheral blood stem cells (n=541) after a reduced-intensity conditioning regimen. | 23935024 |
| Gaucher Disease, Type 1 | Stem Cell Exhaustion | A prospective study of bone marrow hematopoietic and mesenchymal stem cells in type 1 Gaucher disease patients. | 23935976 |
| Small Nuclear Ribonucleoprotein Polypeptide F | Stem Cell Exhaustion | In 15 cases of KSs diagnosed during 2000-2011, the clinicopathological features were correlated with the immunoexpression of c-Kit, SMA, CD34, CD31, vascular endothelial growth factor (VEGF), COX-2, c-KIT, smooth muscle antigen (SMA), and stem cell surface marker CD105. | 23936513 |
| leukemia, Leukemia, Myelocytic, Acute, Chromosome Aberrations | Stem Cell Exhaustion | The recognition of specific cytogenetic abnormalities present in FA known to predispose to AML is crucial for early haematopoietic stem cell transplant (HSCT) before transformation to leukemia. | 23937881 |
| Transplant-Related Malignant Neoplasm, Malnutrition | Stem Cell Exhaustion | Allogeneic haematopoietic stem-cell transplantation (allo-HSCT) is associated with frequent and severe malnutrition, which may contribute to transplant-related morbidity. | 23938114 |
| Multiple Myeloma | Stem Cell Exhaustion | The impact of novel drugs for treating multiple myeloma (MM) on the utilization and outcomes of autologous hematopoietic progenitor cell transplantation (AHPCT) is unknown. | 23939198 |
| Malignant tumor of colon | Stem Cell Exhaustion | This paper reports the case of a patient with an advanced colonic cancer in the era of stem cell therapy. | 23941680 |
| Specialty Type - cancer | Stem Cell Exhaustion | Healing stories: narrative characteristics in cancer survivorship narratives and psychological health among hematopoietic stem cell transplant survivors. | 23942197 |
| Depression, CTCAE, Illness (finding), Anxiety Disorders | Stem Cell Exhaustion | Survivors of hematopoietic stem cell transplant (HSCT) have experienced a life threatening and potentially traumatic illness and treatment that make them vulnerable to long lasting negative psychological outcomes, including anxiety and depression. | 23942197 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Autologous stem cell transplantation in mantle cell lymphoma: a report from the SFGM-TC. | 23949376 |
| Medial collateral ligament, Mantle cell lymphoma | Stem Cell Exhaustion | Autologous stem cell transplantation (ASCT) is considered as an attractive treatment option for young mantle cell lymphoma (MCL) patients. | 23949376 |
| Specialty Type - cancer, Carcinogenesis | Stem Cell Exhaustion | Cancer stem cells biomarkers in gastric carcinogenesis. | 23949555 |
| Specialty Type - cancer, Carcinogenesis | Stem Cell Exhaustion | Gastric carcinogenesis is a multistep process, involving multiple molecular alterations, including changes in cancer stem cells (CSCs). | 23949555 |
| Specialty Type - cancer, Carcinogenesis | Stem Cell Exhaustion | The present investigation was undertaken to determine whether changes in cancer stem cells could be utilized as a marker of progression of gastric carcinogenesis by examining the expression of gastric CSCs at different stages of carcinogenesis. | 23949555 |
| Blood Coagulation Disorders | Stem Cell Exhaustion | Effect of recombinant human soluble thrombomodulin on clinical outcomes of patients with coagulopathy after hematopoietic stem cell transplantation. | 23952647 |
| Rhabdomyosarcoma, Hemorrhagic cystitis, Aplastic Anemia, Acute leukemia | Stem Cell Exhaustion | On univariate analysis increased risk of hemorrhagic cystitis was significantly associated with age greater than 5 years, male gender, cyclophosphamide or busulfan chemotherapy, bone marrow or peripheral blood stem cell transplantation, pelvic radiotherapy and underlying diagnoses of rhabdomyosarcoma, acute leukemia and aplastic anemia. | 23954584 |
| Hemorrhagic cystitis | Stem Cell Exhaustion | On multivariate analysis age greater than 5 years, allogeneic bone marrow or peripheral blood stem cell transplantation and pelvic radiotherapy were significantly associated with increased risk of hemorrhagic cystitis. | 23954584 |
| Hemorrhagic cystitis | Stem Cell Exhaustion | Older age, late onset hemorrhagic cystitis, positive urine culture for BK virus and bone marrow or peripheral blood stem cell transplantation were associated with greater disease severity. | 23954584 |
| Hemorrhagic cystitis | Stem Cell Exhaustion | Older age, previous bone marrow or peripheral blood stem cell transplantation and BK virus in the urine are risk factors for hemorrhagic cystitis and are associated with a higher severity score. | 23954584 |
| Retinal defect | Stem Cell Exhaustion | Surgically induced periosteal membrane holds great potential for the treatment of large bone defects representing a simple alternative to combinations of exogenous stem cells, scaffolds and growth factors. | 23954755 |
| B-Cell Lymphomas, Chemosensitivity, Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | Patients with relapsed or refractory diffuse large B cell lymphoma (DLBCL) are treated with salvage regimens and may be considered for high-dose chemotherapy and autologous stem cell transplantation if disease is chemosensitive. | 23955074 |
| Keratosis | Stem Cell Exhaustion | Precancerous actinic keratoses (AKs) (17) and SCCs (27) expressed two telomere phenotypes: (i) tissue-wide evenly short to intermediate and (ii) longer and tissue-wide heterogeneous telomere lengths, suggesting two modes of initiation, with one likely to originate in the epidermal stem cells. | 23955078 |
| Thrombus, Idiopathic pneumonia syndrome | Stem Cell Exhaustion | Idiopathic pneumonia syndrome with thrombotic microangiopathy-related changes after allogeneic hematopoietic stem cell transplantation. | 23955112 |
| Idiopathic pneumonia syndrome, Alveolar | Stem Cell Exhaustion | Idiopathic pneumonia syndrome (IPS), defined as widespread alveolar injury, is a severe complication of hematopoietic stem cell transplantation (HSCT) and a clinical syndrome with variable histopathologic correlates and multiple etiologies. | 23955112 |
| Experimental Organism Malignant Hepatocholangiocellular Carcinoma | Stem Cell Exhaustion | Clinicopathologic significance of combined hepatocellular-cholangiocarcinoma with stem cell subtype components with reference to the expression of putative stem cell markers. | 23955451 |
| Experimental Organism Malignant Hepatocholangiocellular Carcinoma | Stem Cell Exhaustion | To examine the clinicopathologic features of combined hepatocellular-cholangiocarcinoma (HC-CC), which the World Health Organization (WHO) proposed classifying into 2 types, and the expression of delta-like 1 homolog (DLK1), as well as putative stem cell markers, such as NCAM/CD56 and CD133. | 23955451 |
| Malignant neoplasm of liver | Stem Cell Exhaustion | The 2010 WHO classification seems important for elucidating the pathogenesis of stem cell-related liver cancers. | 23955451 |
| Coinfection | Stem Cell Exhaustion | Co-infections with cytomegalovirus and human herpesvirus type 7 in adult Polish allogeneic haematopoietic stem cell transplant recipients. | 23955532 |
| Communicable Diseases | Stem Cell Exhaustion | Human herpesvirus 7 (HHV-7) is widespread around the world and may also be a possible cofactor for cytomegalovirus (CMV) infection in haematopoietic stem cell transplant (HSCT) recipients. | 23955532 |
| Thalassemia | Stem Cell Exhaustion | Long-term health-related quality of life evaluated more than 20 years after hematopoietic stem cell transplantation for thalassemia. | 23958950 |
| Infection | Stem Cell Exhaustion | Cytomegalovirus (CMV) infections continue to cause significant morbidity and mortality in hematopoietic stem cell transplant (HSCT) recipients. | 23959787 |
| Myeloma kidney, Multiple Myeloma | Stem Cell Exhaustion | Safety and efficacy of autologous hemopoietic progenitor cell collection in tandem with hemodialysis in multiple myeloma with myeloma cast nephropathy. | 23959911 |
| Multiple Myeloma | Stem Cell Exhaustion | Autologous hemopoietic progenitor cell (HPC) collection is the most frequent indication for an apheresis procedure in patients with multiple myeloma, up to 10% of whom may also require hemodialysis because of myeloma kidney. | 23959911 |
| Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | We assessed the prevalence and clinical features of genital skin changes in men after allogeneic hematopoietic stem cell transplantation (HSCT) and evaluated the correlation between genital chronic graft-versus-host disease (cGVHD) and other manifestations of cGVHD as well as sexual issues. | 23962394 |
| Adult Glioblastoma, Neoplasms | Stem Cell Exhaustion | Suberoylanilide hydroxamic acid (SAHA) causes tumor growth slowdown and triggers autophagy in glioblastoma stem cells. | 23962875 |
| Adult Glioblastoma | Stem Cell Exhaustion | Here, we report that SAHA specifically triggers autophagy and reduces cell viability via promotion of apoptosis in the late phase of glioblastoma stem cells (GSCs). | 23962875 |
| Chronic Lymphocytic Leukemia, Neoplasms | Stem Cell Exhaustion | Low tumor burden is associated with early B-cell reconstitution and is a predictor of favorable outcome after non-myeloablative stem cell transplant for chronic lymphocytic leukemia. | 23964650 |
| Sleep Apnea, Obstructive, Aortic Stiffness | Stem Cell Exhaustion | Patients with obstructive sleep apnea syndrome and traditional risk factors also exhibit increased aortic and carotid stiffness, increased renal resistive index and intima-media thickness, and reduced expression of the endothelial progenitor cell marker CD34: however, these parameters were similar to those of healthy controls in patients with isolated obstructive sleep apnea syndrome. | 23965549 |
| Cessation of life, Specialty Type - cancer | Stem Cell Exhaustion | Disulfiram and doxorubicin cooperated to induce cell death as well as cellular senescence, and targeted the ESA(+)/CD24(-/low)/CD44(+) cancer stem cell population. | 23974104 |
| Osteoporotic Fractures | Stem Cell Exhaustion | In the present study, we evaluated the potential for aminobisphosphonates to enhance the development of bone-forming osteoblasts from progenitor cells isolated from aged female osteoporotic patients. | 23974861 |
| Lymphoma | Stem Cell Exhaustion | Stem cell mobilization in HIV seropositive patients with lymphoma. | 23975176 |
| AIDS-Related Hodgkin Lymphoma | Stem Cell Exhaustion | High-dose chemotherapy with autologous peripheral blood stem cell rescue has been reported as feasible and effective in HIV-associated lymphoma. | 23975176 |
| HIV Infections | Stem Cell Exhaustion | HIV infection alone should not preclude an attempt to obtain stem cells in candidates for autologous transplant as the results are comparable to the HIV-negative population. | 23975176 |
| Bacteremia, Communicable Diseases | Stem Cell Exhaustion | Oral infection may be a source of bacteremia in patients undergoing hematopoietic stem cell transplant (HSCT). | 23975228 |
| Communicable Diseases | Stem Cell Exhaustion | [Prevalence of EBV infection in patients with allogeneic hematopoietic stem cell transplantation]. | 23978013 |
| Chronic graft-versus-host disease | Stem Cell Exhaustion | [Association of the ratio of regulatory and effector T cells with recurrence and chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation]. | 23978019 |
| Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | To investigate the association of the ratio of regulatory and effector T cells with recurrence and chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 23978019 |
| Adenocarcinoma of pancreas | Stem Cell Exhaustion | Modulation of c-kit expression in pancreatic adenocarcinoma: a novel stem cell marker responsible for the progression of the disease. | 23978330 |
| Specialty Type - cancer | Stem Cell Exhaustion | The absence of c-kit in normal pancreas and its appearance in PDAC is probably due to a mutational event, which probably allows conversion of the b cells into cancer stem cells (CSC). | 23978330 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Long-term results of a prospective randomized trial evaluating G-CSF priming in intensive induction chemotherapy followed by autologous stem cell transplantation in elderly patients with acute myeloid leukemia. | 23978944 |
| Acute Radiation Syndrome | Stem Cell Exhaustion | Severe acute radiation syndrome: treatment of a lethally 60Co-source irradiated accident victim in China with HLA-mismatched peripheral blood stem cell transplantation and mesenchymal stem cells. | 23979075 |
| Leukemia, Myelocytic, Acute, Acute leukemia | Stem Cell Exhaustion | Allogeneic hematopoietic stem-cell transplantation for acute myeloid leukemia in remission: comparison of intravenous busulfan plus cyclophosphamide (Cy) versus total-body irradiation plus Cy as conditioning regimen--a report from the acute leukemia working party of the European group for blood and marrow transplantation. | 23980086 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Cyclophosphamide (Cy) combined with total-body irradiation (TBI) or with busulfan (Bu) are currently the most common myeloablative regimens used in allogeneic stem-cell transplantation (alloSCT) in adults with acute myelogenous leukemia (AML). | 23980086 |
| Acute myocardial infarction | Stem Cell Exhaustion | In experimental studies, mesenchymal stem cell (MSC) transplantation in acute myocardial infarction (AMI) models has been associated with enhanced neovascularization and myogenesis. | 23982478 |
| Acute myocardial infarction | Stem Cell Exhaustion | Intramyocardial injection of autologous bone marrow-derived ex vivo expanded mesenchymal stem cells in acute myocardial infarction patients is feasible and safe up to 5 years of follow-up. | 23982478 |
| Papillary thyroid carcinoma, Anaplastic thyroid carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Expression of cancer stem cell markers is more frequent in anaplastic thyroid carcinoma compared to papillary thyroid carcinoma and is related to adverse clinical outcome. | 23986551 |
| Specialty Type - cancer | Stem Cell Exhaustion | Additionally, the cancer stem cell (CSC) theory has been widely accepted in the pathogenesis of ATC. | 23986551 |
| Lymphohistiocytosis, Hemophagocytic | Stem Cell Exhaustion | Cognitive and psychosocial function post hematopoietic stem cell transplantation in children with hemophagocytic lymphohistiocytosis. | 23987797 |
| Lymphohistiocytosis, Hemophagocytic | Stem Cell Exhaustion | This study investigated the cognitive and psychosocial outcomes in childhood survivors of hemophagocytic lymphohistiocytosis after hematopoietic stem cell transplantation. | 23987797 |
| Glioblastoma Multiforme Pathway, Neoplasms | Stem Cell Exhaustion | Recent evidence suggests that a glioma stem cell subpopulation may determine the biological behavior of tumors, including resistance to therapy. | 23991844 |
| Glioma, Neoplasms | Stem Cell Exhaustion | To investigate this hypothesis, the authors examined varying grades of gliomas for stem cell marker expressions and histopathological changes between primary and recurrent tumors. | 23991844 |
| Glioblastoma Multiforme Pathway, Specialty Type - cancer, Glioblastoma | Stem Cell Exhaustion | The authors' results indicate that CD133-positive glioma stem cells could survive, change to a proliferative cancer stem cell phenotype, and cause recurrence in cases with de novo glioblastomas after radiotherapy and chemotherapy. | 23991844 |
| Peripheral Arterial Diseases | Stem Cell Exhaustion | Regeneration of the occluded peripheral arteries by autologous stem cell therapy is an emerging treatment modality for no-option patients with peripheral artery disease (PAD). | 23993298 |
| Multiple Myeloma | Stem Cell Exhaustion | Evolving strategies with immunomodulating drugs and tandem autologous/allogeneic hematopoietic stem cell transplantation in first line high risk multiple myeloma patients. | 23994781 |
| Toxic effect, Multiple Myeloma | Stem Cell Exhaustion | We prospectively evaluated in high-risk myeloma patients the efficacy and toxicity of tandem autologous hematopoietic stem cell transplantation (auto-HSCT) followed by reduced-intensity conditioning (RIC) and allogeneic (allo)-HSCT with bortezomib and donor lymphocyte infusions introduction after allo-HSCT (group 1). | 23994781 |
| Hantavirus Infections, Subcutaneous panniculitis-like T-cell lymphoma, Histiocytosis haematophagic | Stem Cell Exhaustion | Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) with hemophagocytosis (HPS): successful treatment using high-dose chemotherapy (BFM-NHL & ALL-90) and autologous peripheral blood stem cell transplantation. | 23995110 |
| Bacteremia | Stem Cell Exhaustion | Incidence, risk factors, and outcome of bacteremia following autologous hematopoietic stem cell transplantation in 720 adult patients. | 23995612 |
| Bacteremia, Pregnancy Complications, Infectious, Neutropenia | Stem Cell Exhaustion | Bacteremia is the most frequent infectious complication during neutropenia in patients receiving autologous hematopoietic stem cell transplantation (ASCT). | 23995612 |
| melphalan/prednisone protocol | Stem Cell Exhaustion | At first randomization, patients (N = 1,970) were assigned to bisphosphonate (clodronic acid or zoledronic acid) and induction therapies [cyclophosphamide-vincristine-doxorubicin-dexamethasone (CVAD) or cyclophosphamide-thalidomide-dexamethasone (CTD) followed by high-dose therapy plus autologous stem cell transplantation for younger/fitter patients (intensive pathway), and melphalan-prednisone (MP) or attenuated CTD (CTDa) for older/less fit patients (nonintensive pathway)]. | 23995858 |
| Renal Insufficiency, Multiple Myeloma | Stem Cell Exhaustion | Bortezomib before and after autologous stem cell transplantation overcomes the negative prognostic impact of renal impairment in newly diagnosed multiple myeloma: a subgroup analysis from the HOVON-65/GMMG-HD4 trial. | 23996482 |
| Renal Insufficiency, Multiple Myeloma | Stem Cell Exhaustion | This analysis evaluates the prognostic role of renal impairment in patients with myeloma treated with bortezomib before and after autologous stem cell transplantation within a prospective randomized phase III trial. | 23996482 |
| Multiple Myeloma | Stem Cell Exhaustion | Eight hundred and twenty-seven newly diagnosed myeloma patients in the HOVON-65/GMMG-HD4 trial were randomized to receive three cycles of vincristine, adriamycin, dexamethasone (VAD) or bortezomib, adriamycin, dexamethasone (PAD) followed by autologous stem cell transplantation and maintenance with thalidomide 50 mg daily (VAD-arm) or bortezomib 1.3 mg/m(2) every 2 weeks (PAD-arm). | 23996482 |
| Renal Insufficiency, Multiple Myeloma | Stem Cell Exhaustion | We conclude that a bortezomib-containing treatment before and after autologous stem cell transplantation overcomes the negative prognostic impact of renal impairment in patients with newly diagnosed multiple myeloma. | 23996482 |
| Chronic myeloproliferative disorder | Stem Cell Exhaustion | Ploycythaemia vera (PV) is most common of chronic myeloproliferative disorder that involves the multipotent haemaotopoietic progenitor cells. | 24000512 |
| Medial collateral ligament, Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | Stem Cell Exhaustion | Although dose-intensive strategies or high-dose therapy induction followed by autologous stem-cell transplantation have improved the outcome for patients with mantle-cell lymphoma (MCL), most eventually relapse and subsequently respond poorly to additional therapy. | 24002500 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Identification of gene expression-based prognostic markers in the hematopoietic stem cells of patients with myelodysplastic syndromes. | 24002510 |
| Tracheal Stenosis | Stem Cell Exhaustion | Replacement of a tracheal stenosis with a tissue-engineered human trachea using autologous stem cells: a case report. | 24004248 |
| Tracheal Stenosis | Stem Cell Exhaustion | In this study, using a detergent-enzymatic method, we prepared an intact three-dimensional scaffold of an extracellular matrix derived from a human cadaver donor trachea, which we repopulated with autologous stem cells and implanted into a 76-year-old patient with tracheal stenosis including the lower part of the larynx. | 24004248 |
| Lymphoma, Vomiting, Multiple Myeloma, Nausea | Stem Cell Exhaustion | Combined use of multiday palonosetron with aprepitant and low-dose dexamethasone in prevention of nausea and emesis among patients with multiple myeloma and lymphoma undergoing autologous hematopoietic stem cell transplant: A pilot study. | 24005093 |
| Refractory Chemotherapy-Induced Nausea and Vomiting | Stem Cell Exhaustion | The current standard for prevention of chemotherapy-induced nausea/vomiting in autologous stem cell transplant only achieves 4-20% emetic control. | 24005093 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | To assess emetic responses to multiday palonosetron, aprepitant, and low-dose dexamethasone among patients with myeloma and lymphoma undergoing autologous hematopoietic stem cell transplant. | 24005093 |
| Neoplasms, Malignant Neoplasms | Stem Cell Exhaustion | Because testicular germ cell tumor recurrence and other malignant tumors could be ruled out pathologically, he was diagnosed as having AML.Allogeneic stem cell transplantation from a HLA-matched sibling donor was performed after chemotherapy. | 24005437 |
| Specialty Type - cancer | Stem Cell Exhaustion | Critics have suggested that neoadjuvant chemotherapy (NACT) followed by interval debulking may select for resistant clones or cancer stem cells when compared to primary cytoreduction. | 24005572 |
| Lymphoma | Stem Cell Exhaustion | High-dose therapy with autologous stem cell support for lymphoma in Norway 1987-2008. | 24005706 |
| Lymphoma | Stem Cell Exhaustion | High-dose therapy with autologous stem cell support (HDT) has been a treatment option for lymphomas in Norway for 25 years. | 24005706 |
| Systemic Scleroderma | Stem Cell Exhaustion | [Treatment and course of a man with systemic sclerosis before and after hematopoetic blood stem cell transplantation]. | 24006162 |
| Sclerosis of the skin | Stem Cell Exhaustion | Six months after blood stem cell transplantation a decrease of skin sclerosis and an increasing recovery of joint mobility and physical strength was observed. | 24006162 |
| Systemic Scleroderma | Stem Cell Exhaustion | Patients with a progressive systemic sclerosis and further risk factors should be treated with high-dose chemotherapy with blood stem cell transplantation before organ function is severely compromised. | 24006162 |
| Antilymphocyte Serum | Stem Cell Exhaustion | Stem cell transplantation is a potential therapeutic strategy for ALS, and the reprogramming of adult somatic cells into induced pluripotent stem cells (iPSCs) represents a novel cell source. | 24006477 |
| Amyotrophic Lateral Sclerosis | Stem Cell Exhaustion | Minimally invasive transplantation of iPSC-derived ALDHhiSSCloVLA4+ neural stem cells effectively improves the phenotype of an amyotrophic lateral sclerosis model. | 24006477 |
| Adenoma | Stem Cell Exhaustion | We evaluated the expression of aldehyde dehydrogenase isoform 1A1 (ALDH1A1), a putative stem cell marker, in baseline adenomas from the placebo arm of chemoprevention trial participants with colonoscopic follow-up. | 24008128 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells have tumor-initiation and tumor-maintenance capabilities. | 24008128 |
| Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | The present study supports the hypothesis that the stem cell population can be enriched in cells expressing the CD133 cell surface marker and that highly expressed CD133 is involved in the occurrence of NSCLC. | 24008862 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cells (CSCs) are a small population of undifferentiated cancer cells within tumors, which contribute to tumorigenicity and relapse. | 24008862 |
| Colorectal Carcinoma, Neoplasms, Cytogenetic Complete Response | Stem Cell Exhaustion | CD44 marks stem cell-like cells in a number of tumour types, including colorectal cancer (CRC), while aberrant CD44 expression conveys increased tumourigenic, invasive, and metastatic potential. | 24009708 |
| Liver carcinoma | Stem Cell Exhaustion | We investigated the transcription program deregulated in hepatocellular carcinomas with stem cell features. | 24012616 |
| Liver carcinoma | Stem Cell Exhaustion | The transcription factor SALL4, known to regulate stemness in embryonic and hematopoietic stem cells, was found to be activated in a hepatocellular carcinoma subtype with stem cell features. | 24012616 |
| Specialty Type - cancer | Stem Cell Exhaustion | Activation of SALL4 enhanced spheroid formation and invasion capacities, key characteristics of cancer stem cells, and up-regulated the hepatic stem cell markers KRT19, EPCAM, and CD44 in cell lines. | 24012616 |
| Liver carcinoma | Stem Cell Exhaustion | SALL4 is a valuable biomarker and therapeutic target for the diagnosis and treatment of hepatocellular carcinoma with stem cell features. | 24012616 |
| Fibrosis Assessment | Stem Cell Exhaustion | To determine the effect of fibrosis on healthy hematopoietic progenitor cells (HPCs), bioartificial matrixes from rat tail or purified human collagen were found to suppress HPC differentiation and proliferation. | 24014875 |
| Malignant neoplasm of lung | Stem Cell Exhaustion | To investigate the expression of the stem cell marker Nanog in lung cancer tissues and the correlations between Nanog expression and clinic-pathologic characteristics as well as prognosis of lung cancer. | 24018162 |
| Leukemia, Myelocytic, Acute, Acute lymphocytic leukemia | Stem Cell Exhaustion | We analyzed 3339 patients with acute myeloid leukemia and 1434 patients with acute lymphoblastic leukemia who received myeloablative conditioning and related or unrelated stem cells from 1990 to 2005. | 24018394 |
| MS gene | Stem Cell Exhaustion | With autologous mesenchymal stem cell therapy now in the early phases of clinical trials for all forms of multiple sclerosis (MS), it is necessary to determine whether autologous stem cells from older donors have therapeutic effectiveness. | 24018793 |
| Experimental Autoimmune Encephalomyelitis | Stem Cell Exhaustion | Age of the donor reduces the ability of human adipose-derived stem cells to alleviate symptoms in the experimental autoimmune encephalomyelitis mouse model. | 24018793 |
| Sepsis | Stem Cell Exhaustion | He suffered persistent neutropaenic sepsis and clinical deterioration forced the strategy of matched sibling haematopoietic stem cell transplantation. | 24019212 |
| Toxic effect, Anthracycline Antibiotics | Stem Cell Exhaustion | First-line treatment with anthracycline-based polychemotherapy followed by consolidation with high-dose therapy and autologous stem cell transplant in responding patients has demonstrated good feasibility with low toxicity in prospective studies and is widely used in eligible patients. | 24020452 |
| Malignant tumor of colon, Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cell gene profile as predictor of relapse in high risk stage II and stage III, radically resected colon cancer patients. | 24023782 |
| Colorectal Carcinoma, Malignant tumor of colon | Stem Cell Exhaustion | This analysis supports the idea that, other than stage, biological variables, such as expression levels of colon cancer stem cell genes, may be relevant in determining an increased risk of relapse in resected colorectal cancer patients. | 24023782 |
| Colorectal Carcinoma, Specialty Type - cancer, Malignant tumor of colon | Stem Cell Exhaustion | Preclinical findings suggest that cancer stem cells may influence the biological behaviour of colorectal cancer independently from stage: objective of the study was to assess whether a panel of stemness markers were correlated with clinical outcome in resected stage II and III colon cancer patients. | 24023782 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | SNPs in the Prostate Stem Cell Antigen (PSCA) gene have been found associated with gastric cancer (GC) risk in a genome-wide association study. | 24023815 |
| Down Syndrome | Stem Cell Exhaustion | Usp16 contributes to somatic stem-cell defects in Down's syndrome. | 24025767 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Forty-two CLL patient samples were repeatedly analyzed after allogeneic stem cell transplantation (n = 20) or after fludarabine-based therapy (n = 22), and 100% concordance was found using both flow cytometric protocols. | 24028768 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Blood-derived circulatory angiogenic cells (CACs) and resident cardiac stem cells (CSCs) have both been shown to improve cardiac function after myocardial infarction. | 24030393 |
| melanoma | Stem Cell Exhaustion | The intermediate filament nestin, a neural stem-cell marker, is reported to be expressed more strongly in melanomas compared with benign melanocytic lesions, and increasingly expressed in advanced melanoma stages. | 24030749 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | This international, multicentre phase II study was conducted to assess ofatumumab, a human anti-CD20 monoclonal antibody, in patients with relapsed/progressive diffuse large B-cell lymphoma (DLBCL) who were ineligible for autologous stem cell transplantation (TI) or who had relapse/progression after transplantation (PT). | 24032456 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | Decreased and dysfunctional circulating endothelial progenitor cells in patients with chronic obstructive pulmonary disease. | 24033940 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | In order to define the altered pulmonary vascular homeostasis in chronic obstructive pulmonary disease, we sought to observe the level and functions of circulating endothelial progenitor cells in patients with chronic obstructive pulmonary disease. | 24033940 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | Adhesion, proliferation, production of nitric oxide, and expression of endothelial nitric oxide synthase and phosphorylated-endothelial nitric oxide synthase were detected to determine functions of circulating endothelial progenitor cells in patients with chronic obstructive pulmonary disease. | 24033940 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | The number of circulating endothelial progenitor cells in the chronic obstructive pulmonary disease group was lower than in the control group: (0.54 +- 0.16)% vs. (1.15 +- 0.57)%, P < 0.05. | 24033940 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | Compared with the control, there were significantly fewer adhering endothelial progenitor cells in chronic obstructive pulmonary disease patients: 18.7 +- 4.8/field vs. 45.0 +- 5.9/field, P < 0.05. | 24033940 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | The proliferation assay showed that the proliferative capacity of circulating endothelial progenitor cells from chronic obstructive pulmonary disease patients was significantly impaired: 0.135 +- 0.038 vs. 0.224 +- 0.042, P < 0.05. | 24033940 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | Circulating endothelial progenitor cells were decreased and functionally impaired in patients with chronic obstructive pulmonary disease. | 24033940 |
| Dyskeratosis Congenita | Stem Cell Exhaustion | Fludarabine, low-dose cyclophosphamide and rabbit antithymocyte globulin allowed stable engraftment after allogeneic peripheral blood stem cell transplantation for poly-transfused dyskeratosis congenita patient: case report. | 24034063 |
| Allogeneic Hematopoietic Stem Cell Transplantation, Crohn Disease, Acute leukemia | Stem Cell Exhaustion | Successful treatment of both acute leukemia and active Crohn's disease after allogeneic hematopoietic stem cell transplantation using reduced-intensity conditioning with fludarabine and busulfan: a case report. | 24034064 |
| Clostridium difficile colitis, Central Diabetes Insipidus | Stem Cell Exhaustion | Clostridium difficile infection (CDI) is a serious complication of chemotherapy including high-dose regimens with autologous stem cell transplantation (ASCT). | 24034141 |
| Tumor necrosis | Stem Cell Exhaustion | Interleukin-1 beta and tumor necrosis factor alpha inhibit migration activity of chondrogenic progenitor cells from non-fibrillated osteoarthritic cartilage. | 24034344 |
| cytidylyl-(3-5)-cytidine | Stem Cell Exhaustion | Migratory chondrogenic progenitor cells (CPC) might represent a target cell population for in situ regeneration. | 24034344 |
| Electrocardiogram: myocardial infarction (finding), Ventricular Dysfunction | Stem Cell Exhaustion | Intracoronary cardiosphere-derived cells after myocardial infarction: evidence of therapeutic regeneration in the final 1-year results of the CADUCEUS trial (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction). | 24036024 |
| Ventricular Dysfunction | Stem Cell Exhaustion | This study sought to report full 1-year results, detailed magnetic resonance imaging analysis, and determinants of efficacy in the prospective, randomized, controlled CADUCEUS (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction) trial. | 24036024 |
| Caduceus, Ventricular Dysfunction | Stem Cell Exhaustion | (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction [CADUCEUS]; NCT00893360). | 24036024 |
| Thymic Lymphoma | Stem Cell Exhaustion | Somatic inactivation of Tp53 in hematopoietic stem cells or thymocytes predisposes mice to thymic lymphomas with clonal translocations. | 24036547 |
| Hematoma, Subdural | Stem Cell Exhaustion | The level of circulating endothelial progenitor cells may be associated with the occurrence and recurrence of chronic subdural hematoma. | 24037002 |
| Hematoma, Subdural, Chronic, Hematoma, Subdural | Stem Cell Exhaustion | This study was designed to observe the levels of endothelial progenitor cells, white blood cells, platelets, and other indicators in the peripheral blood of patients diagnosed with chronic subdural hematoma to determine the possible relationship between the endothelial progenitor cells and the occurrence, development, and outcomes of chronic subdural hematoma. | 24037002 |
| Hematoma | Stem Cell Exhaustion | The level of endothelial progenitor cells in peripheral blood was significantly lower in preoperational patients with chronic subdural hematomas than in controls. | 24037002 |
| Hematoma | Stem Cell Exhaustion | The level of circulating endothelial progenitor cells in chronic subdural hematoma patients was significantly lower than the level in healthy controls. | 24037002 |
| Hematoma, Subdural | Stem Cell Exhaustion | Endothelial progenitor cells may be related to the occurrence and recurrence of chronic subdural hematoma. | 24037002 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Effective prevention of GVHD using in vivo T-cell depletion with anti-lymphocyte globulin in HLA-identical or -mismatched sibling peripheral blood stem cell transplantation. | 24037022 |
| Bone necrosis | Stem Cell Exhaustion | Aberrant CpG islands' hypermethylation of ABCB1 in mesenchymal stem cells of patients with steroid-associated osteonecrosis. | 24037553 |
| Impaired T cell function | Stem Cell Exhaustion | We investigated whether aberrant dinucleotide CpG islands' hypermethylation of ABCB1 gene existed in mesenchymal stem cells (MSC) of patients with ONFH, which results in cell dysfunction. | 24037553 |
| leukemia, Acute leukemia | Stem Cell Exhaustion | CMV serostatus still has an important prognostic impact in de novo acute leukemia patients after allogeneic stem cell transplantation: a report from the Acute Leukemia Working Party of EBMT. | 24037724 |
| Acute leukemia | Stem Cell Exhaustion | We analyzed the prognostic impact of donor and recipient cytomegalovirus (CMV) serostatus in 16,628 de novo acute leukemia patients after allogeneic stem cell transplantation (allo-SCT). | 24037724 |
| Astrocytoma | Stem Cell Exhaustion | A study of embryonic stem cell-related proteins in human astrocytomas: identification of Nanog as a predictor of survival. | 24037901 |
| Glioma, Childhood Breast Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | An embryonic stem cell (ESC) gene signature was found to correlate with a more undifferentiated phenotype of several human cancer types including gliomas, and associated with poor prognosis in breast cancer. | 24037901 |
| Malignant Neoplasms | Stem Cell Exhaustion | Recent studies suggest that the regulatory networks controlling the functions of stem cells during development may be abnormally active in human cancers. | 24037901 |
| Cytomegalovirus DNA, Aspergillosis | Stem Cell Exhaustion | An investigation on the relationship between the occurrence of CMV DNAemia and the development of invasive aspergillosis in the allogeneic stem cell transplantation setting. | 24037906 |
| Communicable Diseases, Mycoses | Stem Cell Exhaustion | Cytomegalovirus (CMV) infection might increase the risk of fungal superinfection in allogeneic stem cell transplant patients. | 24037906 |
| Injury wounds | Stem Cell Exhaustion | We evaluated the treatment of excisional and diabetic wounds using a stem cell isolated from the human umbilical cord Wharton's jelly (hWJSC) that shares unique properties with embryonic and adult mesenchymal stem cells. | 24038311 |
| Injury wounds | Stem Cell Exhaustion | Human Wharton's jelly stem cells and its conditioned medium enhance healing of excisional and diabetic wounds. | 24038311 |
| Neoplasms | Stem Cell Exhaustion | Irradiation of juvenile, but not adult, mammary gland increases stem cell self-renewal and estrogen receptor negative tumors. | 24038768 |
| Neoplasms | Stem Cell Exhaustion | Here we show that pubertal murine mammary glands exposed to sparsely or densely ionizing radiation exhibit enrichment of mammary stem cell and Notch pathways, increased mammary repopulating activity indicative of more stem cells, and propensity to develop estrogen receptor (ER) negative tumors thought to arise from stem cells. | 24038768 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | These studies suggest that irradiation during puberty transiently increases stem cell self-renewal, which increases susceptibility to developing ER-negative breast cancer. | 24038768 |
| Fracture, Hematoma | Stem Cell Exhaustion | Previously, we reported that progenitor cells with osteogenic and chondrogenic potential exist in human fracture haematoma, suggesting that the fracture haematoma-derived progenitor cells (HCs) contribute to fracture healing. | 24039091 |
| Malignant tumor of colon, Specialty Type - cancer | Stem Cell Exhaustion | Cancer-initiating cells [cancer stem cells (CSCs)] in colon cancer cells can be selectively suppressed when they are cultured on Pluronic (nanosegment)-grafted dishes, whereas CSCs are maintained on conventional tissue culture dishes and extracellular matrix-coated dishes. | 24039170 |
| Malignant tumor of colon | Stem Cell Exhaustion | CSCs can be selectively suppressed from colon cancer cells containing adipose-derived stem cells (ADSCs) on Pluronic-grafted dishes, while ADSCs remain on the dishes. | 24039170 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Despite improvements in human leukocyte antigen matching and pharmacologic prophylaxis, acute graft-versus-host disease (GVHD) is often a fatal complication following hematopoietic stem cell transplant (HSCT). | 24040397 |
| Specialty Type - cancer | Stem Cell Exhaustion | To evaluate the safety, tolerability, pharmacokinetics and antitumor activities of famitinib (famitinib L-malate), a novel oral multitargeting tyrosine kinase inhibitor that acts against vascular endothelial growth factor receptor-2, platelet-derived growth factor receptor, stem cell factor receptor (c-kit), FMS-like tyrosine kinase-3 receptor and protooncogene tyrosine kinase receptor in patients with advanced solid cancer. | 24043137 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Clinical outcomes of allogeneic stem cell transplantation for relapsed or refractory follicular lymphoma: a retrospective analysis by the Fukuoka Blood and Marrow Transplantation Group. | 24043582 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (allo-SCT) is considered the only curative treatment for relapsed or refractory follicular lymphoma (FL), but it has a high treatment-related mortality rate. | 24043582 |
| CLU protein, human, Ischemia | Stem Cell Exhaustion | Stem cells have been successfully used for the treatment of critical limb ischemia (CLI). | 24043757 |
| Multiple Myeloma | Stem Cell Exhaustion | We prospectively evaluated the effect of bortezomib, thalidomide and dexamethasone (VTD) consolidation on bone metabolism of 42 myeloma patients who underwent an autologous stem cell transplantation (ASCT). | 24045498 |
| Neoplasms | Stem Cell Exhaustion | In particular, SKOV3 cells with miR-106a overexpression had significantly higher tumor initial/stem cell population (CD24- and CD133-positive cells) than control SKOV3 cells. | 24045973 |
| Myoma, physiopathological | Stem Cell Exhaustion | The possible pathogenetic mechanisms include hormonal dysfunction, differentiation of subperitoneal mesenchymal stem cells, myofibroblastic metaplasia and genetic and iatrogenic causes (resection of myomas during laparoscopic surgery). | 24047039 |
| Heart failure | Stem Cell Exhaustion | Decreased circulating endothelial progenitor cell levels in patients with heart failure with preserved ejection fraction. | 24051936 |
| Heart failure | Stem Cell Exhaustion | The purpose of this study was to explore the relationship between endothelial progenitor cell (EPC) levels, heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF). | 24051936 |
| Lupus Erythematosus | Stem Cell Exhaustion | Endothelial progenitor cells in systemic lupus erythematosus. | 24052468 |
| Stem cells | Stem Cell Exhaustion | This is characterized by increased cytokine secretion, loss of stem cell markers, and astrocytic differentiation. | 24052948 |
| Adult Glioblastoma, Specialty Type - cancer | Stem Cell Exhaustion | Furthermore, glioblastoma assays reveal that irradiation therapy affects the tumorigenic potential of cancer stem cells by ablating self-renewal and inducing astroglial differentiation. | 24052948 |
| Tumor necrosis, Pneumoconiosis | Stem Cell Exhaustion | In the patients with pneumoconiosis, the highly expressed serum cytokines included interleukin (IL)-1a, IL-1b, IL-2, ILs 4-16, macrophage colony-stimulating factor, interferon-g, tumor necrosis factor (TNF)-a, TNF-b, human bone morphogenetic protein-6, fibroblast growth factor-7, neurotrophin-3, and stem cell factor, and the lowly expressed serum cytokines included recombinant human I-309, monocyte chemoattractant protein (MCP)-1, MCP-2, MCP-3, MCP-4, macrophage inflammatory protein (MIP)-1-d, and MIP-3-a. | 24053915 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Prevalence of extramedullary relapses is higher after allogeneic stem cell transplantation than after chemotherapy in adult patients with acute myeloid leukemia. | 24054717 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Although studies have demonstrated a high prevalence of extramedullary (EM) relapse after allogeneic stem cell transplantation (allo-SCT) in patients with acute myeloid leukemia (AML), the prevalence of EM relapse has not been compared with that after chemotherapy. | 24054717 |
| Hemangioma, Hemangiosarcoma | Stem Cell Exhaustion | In the present study, we semiquantitatively evaluated the expression profiles of hematopoietic stem cell markers (CD117 [c-kit], CD133, CD34, and CD45), endothelial cell markers (vascular endothelial growth factor receptor 2, CD31, and factor VIII-related antigen), and a myeloid lineage cell marker (CD14) in human hemangiosarcoma (n = 12) and hemangioma (n = 10) specimens using immunohistochemistry. | 24054722 |
| Hemangioma, Hemangiosarcoma | Stem Cell Exhaustion | Our results indicate that multipotential bone marrow-derived hematopoietic stem cells or early endothelial progenitor cells (EPCs) expressing CD117, CD34, and CD45 are involved in hemangiosarcoma formation, whereas hemangiomas originate from late EPCs or differentiated endothelial cells, which have lost the expression of most hematopoietic stem cell markers. | 24054722 |
| Heart failure | Stem Cell Exhaustion | Changes in circulating progenitor cells are associated with outcome in heart failure patients: a longitudinal study. | 24054922 |
| Cardiovascular Diseases | Stem Cell Exhaustion | Circulating progenitor cells (CPCs) are involved in the process of endothelial repair and are a prognostic factor in cardiovascular diseases. | 24054922 |
| Diabetes | Stem Cell Exhaustion | Depletion of circulating progenitor cells precedes overt diabetes: a substudy from the VA enhanced fitness trial. | 24055327 |
| Diabetes, "cytidylyl-(3-5)-cytidine | Stem Cell Exhaustion | While depletion of circulating progenitor cells (CPCs) has been noted in diabetes, the degree to which CPC depletion predates and is associated with propensity to develop overt disease is unclear. | 24055327 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Collection of hematopoietic stem cells after previous radioimmunotherapy is feasible and does not impair engraftment after autologous stem cell transplantation in follicular lymphoma. | 24055654 |
| Lymphoma, Follicular, Toxic effect | Stem Cell Exhaustion | Major concerns about radioimmunotherapy (RIT) administration early in the course of follicular lymphoma (FL) are long-term toxicity and the theoretical impairment of hematopoietic stem cell (HSC) harvest, but few data are available about mobilization rates after RIT. | 24055654 |
| Thrombotic Microangiopathies | Stem Cell Exhaustion | Serum neutrophil extracellular trap levels predict thrombotic microangiopathy after allogeneic stem cell transplantation. | 24055655 |
| Thrombotic Microangiopathies | Stem Cell Exhaustion | Transplantation-associated thrombotic microangiopathy (TA-TMA) is a devastating complication of hematopoietic stem cell transplantation. | 24055655 |
| Neurotoxicity Syndromes, "Alzheimers Disease | Stem Cell Exhaustion | Efficient derivation of cortical glutamatergic neurons from human pluripotent stem cells: a model system to study neurotoxicity in Alzheimer's disease. | 24055772 |
| Neurotoxicity Syndromes, Up | Stem Cell Exhaustion | In particular, disease-relevant models based on human pluripotent stem cells (hPSCs) may be promising approaches to assess the impact of neurotoxic agents in AD on specific neuronal populations and thereby facilitate the development of novel interventions to avert early disease mechanisms. | 24055772 |
| Malignant Neoplasms | Stem Cell Exhaustion | Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation. | 24055823 |
| Malignant Neoplasms | Stem Cell Exhaustion | New treatments are needed for B-cell malignancies persisting after allogeneic hematopoietic stem cell transplantation (alloHSCT). | 24055823 |
| CORIN gene | Stem Cell Exhaustion | Corin is also expressed in chondrocytes and bone marrow-derived mesenchymal stem cells that undergo osteogenic differentiation, suggesting a potential role of corin in bone formation and homeostasis. | 24056022 |
| BCR gene | Stem Cell Exhaustion | Reduced-intensity allogeneic stem cell transplantation for patients aged 50 years or older with B-cell ALL in remission: a retrospective study by the Adult ALL Working Group of the Japan Society for Hematopoietic Cell Transplantation. | 24056740 |
| Specialty Type - cancer | Stem Cell Exhaustion | Coexpression of both oncoproteins in cultured cells led to the activation of a c-Myc transcriptional signature and acquisition of a self-renewing phenotype independent of an epithelial-mesenchymal transition programme or regulation of conventional cancer stem cell markers. | 24056965 |
| Neoplasms | Stem Cell Exhaustion | The stem cell self-renewal gene, Musashi 1, is highly expressed in tumor and non-tumor samples of human bladder. | 24061461 |
| Specialty Type - cancer | Stem Cell Exhaustion | The stem cell model for cancer assumes that a key event in tumorigenesis is the deregulation of genes involved in the regulation of stem cell self-renewal. | 24061461 |
| Malignant neoplasm of urinary bladder, Neoplasms | Stem Cell Exhaustion | To investigate a potential expression of the stem cell self-renewal gene, Musashi 1, in human bladder cancer, we examined its gene expression in a series of tumor and non-tumor tissue samples of bladder. | 24061461 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | [Effect of tongguan capsule on the number of endothelial progenitor cells in the peripheral blood of patients with coronary artery disease after PCI]. | 24063204 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | To observe the effect of Tongguan Capsule (TC) on the number of endothelial progenitor cells (EPCs) in the peripheral blood of patients with coronary artery disease (CAD) after percutaneous coronary intervention (PCI). | 24063204 |
| Malignant tumor of colon | Stem Cell Exhaustion | Leucine-rich repeat-containing G protein-coupled receptor 5(LGR5) was identified as the stem cell marker of colon cancer stem cells(CSCs),which were considered as the main criminal cells initiation and reinitiation of colon cancer. | 24063790 |
| Malignant Neoplasms | Stem Cell Exhaustion | Myc is a transcription factor having a central function in stem cell biology and in human cancers. | 24063893 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | Enlargement of bilateral kidneys by infiltration of leukemic cells in acute lymphoblastic leukemia at relapse after allogeneic hematopoietic stem cell transplantation. | 24065514 |
| Hematologic Neoplasms, Bone marrow hypocellularity | Stem Cell Exhaustion | We analysed the results of allogeneic haematopoietic stem cell transplantation (HSCT) in various genetic disorders, bone marrow failures and haematological malignancies done from 2002 to 2010 at the Army Hospital, Research and Referral, Delhi. | 24066986 |
| Fatigue | Stem Cell Exhaustion | Research suggests that patients experience increased fatigue, reduced physical activity, and diminished quality of life (QOL) after hematopoietic stem cell transplantation (HSCT). | 24067357 |
| Zygomycosis, Carotid artery occlusion | Stem Cell Exhaustion | Fatal outcome of rhino-orbital-cerebral mucormycosis due to bilateral internal carotid occlusion in a child after hematopoietic stem cell transplantation. | 24067555 |
| Cerebral Infarction, Zygomycosis, Pre B-cell acute lymphoblastic leukemia | Stem Cell Exhaustion | We present a case of fatal invasive rhino-orbito-cerebral mucormycosis complicated by bilateral thrombotic occlusion of the internal carotid artery with consequent cerebral infarction in a 5-year-old boy after hematopoietic stem cell transplantation for acute pre-B-cell lymphoblastic leukemia. | 24067555 |
| Neuroendocrine Tumors, Neoplasms | Stem Cell Exhaustion | Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms derived from endocrine stem cells.These tumors are characterized by overexpression of somatostatin receptors (SSTR), which is utilized for imaging using SSTR analogs. | 24068636 |
| Up | Stem Cell Exhaustion | In conclusion, Endoret was able to activate neuronal progenitor cells, enhancing hippocampal neurogenesis, and to reduce Ab-induced neurodegeneration in a mouse model of AD. | 24069173 |
| Ischemia | Stem Cell Exhaustion | Characterization of mesenchymal stem cells of "no-options" patients with critical limb ischemia treated by autologous bone marrow mononuclear cells. | 24069226 |
| CLU protein, human | Stem Cell Exhaustion | Mesenchymal stem cells of 41 patients with CLI unsuitable for revascularisation were isolated from mononuclear bone marrow concentrate used for their treatment. | 24069226 |
| diabetic | Stem Cell Exhaustion | The expression of mesenchymal stem cells surface markers that was analyzed in 22 patients did not differ between diabetic (n=13) and non-diabetic (n=9) patient groups. | 24069226 |
| Specialty Type - cancer, Pancreatic carcinoma | Stem Cell Exhaustion | Human pancreatic cancer contains a side population expressing cancer stem cell-associated and prognostic genes. | 24069258 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | In many types of cancers, a side population (SP) has been identified based on high efflux capacity, thereby enriching for chemoresistant cells as well as for candidate cancer stem cells (CSC). | 24069258 |
| Specialty Type - cancer | Stem Cell Exhaustion | Recent data suggest that circulating endothelial and progenitor cells (CECs and CEPs, respectively) may have predictive potential in cancer patients treated with bevacizumab, the antibody recognizing vascular endothelial growth factor (VEGF). | 24069296 |
| Antilymphocyte Serum | Stem Cell Exhaustion | We evaluated the therapeutic effects of human adipose tissue-derived stem cells (ASCs) in an animal model of ALS. | 24070071 |
| Impaired T cell function | Stem Cell Exhaustion | Clinical cardiac cell therapy using autologous somatic stem cells is restricted by age and disease-associated impairment of stem cell function. | 24074138 |
| Heart failure | Stem Cell Exhaustion | Impact of heart failure on the behavior of human neonatal stem cells in vitro. | 24074138 |
| Heart failure | Stem Cell Exhaustion | We therefore evaluated the behavior of neonatal cord blood mesenchymal stem cells (CB-MSC) in the presence of serum from patients with advanced heart failure (HF). | 24074138 |
| HIV-Associated Lymphoproliferative Disorder | Stem Cell Exhaustion | Heterogeneity in clinical course of EBV-associated lymphoproliferative disorder after allogeneic stem cell transplantation. | 24074746 |
| Post-transplant lymphoproliferative disorder | Stem Cell Exhaustion | Post-transplant lymphoproliferative disorder (PTLD) is a severe complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT) associated with Epstein-Barr virus (EBV). | 24074746 |
| Breast Carcinoma, Childhood Breast Carcinoma | Stem Cell Exhaustion | To investigate the expression pattern of Y-box-binding protein 1 (YB1) in breast carcinomas, its clinicopathological and prognostic value, and its association with the breast cancer stem cell phenotype [CD44(+)/CD24(-/low)]. | 24075827 |
| Neoplasms | Stem Cell Exhaustion | Cytoplasmic YB1 is associated with an aggressive and "stem cell-like" tumor phenotype, while nuclear localization discriminates patients at high risk for recurrence, especially those who are subjected to chemo- and radiotherapy. | 24075827 |
| Ductal Carcinoma, Childhood Breast Carcinoma | Stem Cell Exhaustion | Cytoplasmic YB1 was detected more often in carcinomas of ductal type (p = 0.002), of higher nuclear grade (p < 0.001), with lack of ER expression (p = 0.002), positive expression of p53 and Ki67 (p = 0.002 and p = 022, respectively), and with present CD44(+)/CD24(-/low) breast cancer stem cells (p = 0.001), while its association with bcl-2 was found to be inverse (p = 0.042). | 24075827 |
| Ischemic stroke | Stem Cell Exhaustion | The association between circulating endothelial progenitor cells and outcome in different subtypes of acute ischemic stroke. | 24076252 |
| Ischemic stroke | Stem Cell Exhaustion | This study evaluated the relationship between serial changes in circulating endothelial progenitor cells (EPCs) and outcomes in patients with different subtypes of acute ischemic stroke (AIS). | 24076252 |
| Retinal damage | Stem Cell Exhaustion | The potential neuroprotective effect of human adipose stem cells conditioned medium against light-induced retinal damage. | 24076412 |
| Neoplasms, Malignant neoplasm of gallbladder | Stem Cell Exhaustion | miR-34 is associated with poor prognosis of patients with gallbladder cancer through regulating telomere length in tumor stem cells. | 24078448 |
| Peripheral Blood Stem Cells | Stem Cell Exhaustion | The patient received preoperative induction chemotherapy and high-dose chemotherapy with peripheral blood stem cell support, followed by adjuvant chemotherapy and endocrine therapy. | 24081811 |
| Intrahepatic Route of Drug Administration, Hypoxia | Stem Cell Exhaustion | Chronic intermittent hypoxia (IH) acts as a stimulator of mesenchymal stem cell (MSC) mobilization, intensifying osteoblast formation in animal models. | 24082310 |
| Cachexia, Pancreatic carcinoma, Muscle damage | Stem Cell Exhaustion | In tumor-bearing mice and patients with pancreatic cancer, we found that cachexia was associated with a type of muscle damage resulting in activation of both satellite and nonsatellite muscle progenitor cells. | 24084740 |
| Multiple Myeloma | Stem Cell Exhaustion | Impact of failed response to novel agent induction in autologous stem cell transplantation for multiple myeloma. | 24085241 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | The aim of this study was to evaluate the impact of the response to induction therapy on the long-term prognosis of multiple myeloma (MM) after autologous stem cell transplantation (ASCT) in the era of novel agents (NAs). | 24085241 |
| Malignant Neoplasms, Lymphocyte Function, Neutropenia, Lymphopenia, Allogeneic Hematopoietic Stem Cell Transplant Recipient | Stem Cell Exhaustion | Of the 17 candidate variables analyzed, 11 correlated with IMD by univariate analysis, but only 4 risk factors (neutropenia, lymphocytopenia or lymphocyte dysfunction in allogeneic hematopoietic stem cell transplant recipients, malignancy status, and prior IMD) were retained in the final multivariate model, resulting in a weighted risk score 0-13. | 24086555 |
| Multiple Myeloma | Stem Cell Exhaustion | Total marrow irradiation as part of autologous stem cell transplantation for Asian patients with multiple myeloma. | 24089671 |
| Multiple Myeloma | Stem Cell Exhaustion | Between 2007 and 2010, nine consecutive myeloma patients who were scheduled to undergo autologous stem cell transplantation (ASCT) were studied. | 24089671 |
| Hodgkin Disease, LIPC gene | Stem Cell Exhaustion | For Hodgkin lymphoma (HL) patients with refractory or relapsed (R/R) disease after primary therapy, the standard of care is a salvage regimen followed by autologous stem cell transplant (ASCT). | 24094894 |
| Hyperplasia | Stem Cell Exhaustion | The cellular composition of the resulting hyperplastic lesions is controversial, although a population of CD133(+)CD24(+) progenitor cells has been proposed to be a major constituent. | 24095923 |
| Lymphoproliferative Disorders | Stem Cell Exhaustion | In a series of 36 renal biopsies of patients with proliferative and nonproliferative glomerulopathies, dysregulated CD133(+)CD24(+) progenitor cells of the Bowman's capsule invade the glomerular tuft exclusively in proliferative disorders. | 24095923 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Outcomes of autologous or allogeneic stem cell transplantation for non-Hodgkin lymphoma. | 24096123 |
| Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Transplant outcomes of autologous or allogeneic stem cell transplantation (SCT) have not been elucidated as a single cohort in non-Hodgkin lymphoma (NHL). | 24096123 |
| Specialty Type - cancer | Stem Cell Exhaustion | Helicobacter pylori generates cells with cancer stem cell properties via epithelial-mesenchymal transition-like changes. | 24096479 |
| Specialty Type - cancer | Stem Cell Exhaustion | EMT participates in the carcinogenesis process, and is involved in the generation of cancer stem cells (CSCs). | 24096479 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Single center experience with total body irradiation and melphalan (TBI-MEL) myeloablative conditioning regimen for allogeneic stem cell transplantation (SCT) in patients with refractory hematologic malignancies. | 24097082 |
| Lymphoma, Non-Hodgkin, Familial, Hematologic Neoplasms, Leukemia, Myelocytic, Acute, BCR gene | Stem Cell Exhaustion | We retrospectively evaluated the tolerability and efficacy of fractionated total body irradiation (TBI) (1,200 cGy) and melphalan (MEL) (100-110 mg/m(2)) myeloablative conditioning in 48 patients with nonremission AML (n = 14), ALL (n = 10), NHL (n = 18), and other refractory hematologic malignancies (n = 6) who received allogeneic stem cell transplantation (SCT) between 2002 and 2011. | 24097082 |
| leukemia | Stem Cell Exhaustion | Median age was 48 years (22 to 68); 14 out of 26 leukemia patients (54 %) had circulating blasts at transplant, 20 (50 %) evaluable patients had poor-risk cytogenetics, 12 (25 %) had prior SCT, and 10 (21 %) received stem cells from a mismatch donor. | 24097082 |
| Ischemic cardiomyopathy | Stem Cell Exhaustion | Transplantation of ex vivo proliferated cardiac stem cells (CSCs) is an emerging therapy for ischemic cardiomyopathy but outcomes are limited by modest engraftment and poor long-term survival. | 24099706 |
| Signal Transduction, Osteoporotic Fractures | Stem Cell Exhaustion | Mesenchymal stem cells from osteoporotic patients feature impaired signal transduction but sustained osteoinduction in response to BMP-2 stimulation. | 24099772 |
| Fracture | Stem Cell Exhaustion | Cellular sources of fracture healing are mesenchymal stem cells (MSC) that differentiate into osteoblasts by stimulation with osteoinductive cytokines, such as BMP-2. | 24099772 |
| Specialty Type - cancer, Carcinoma | Stem Cell Exhaustion | The purpose of our study was to learn the distribution characteristics of cancer stem cell markers (CD24, CD44) in invasive carcinomas with different grade and molecular subtype. | 24099815 |
| Specialty Type - cancer | Stem Cell Exhaustion | For identify cancer stem cells mononuclear antibodies CD24 (BIOCARE MEDICAL, CD44 - Clone 156-3C11; CD24 - Clone SN3b) were used. | 24099815 |
| Malignant Neoplasms | Stem Cell Exhaustion | As well as amount of CD24 positive cases according to malignancy degree, also antigen expression features does not show any type of correlation between malignancy degree and CD24 positivity or with CD24 expression features, or presence of stem cells. | 24099815 |
| Adenomatous Polyps | Stem Cell Exhaustion | However, a common stem/progenitor cell origin of both the adenomatous and neuronal component of these lesions has been suggested. | 24101276 |
| Specialty Type - cancer | Stem Cell Exhaustion | Expression of human CD133 (human prominin-1) in cancer cells has been postulated to be a marker of stemness and is considered as a putative marker of cancer stem cells (CSCs). | 24102054 |
| Congestive heart failure | Stem Cell Exhaustion | Expression of platelet-bound stromal-cell derived factor-1 (SDF-1) and number of CD34(+) progenitor cells in patients with congestive heart failure. | 24102302 |
| Congestive heart failure | Stem Cell Exhaustion | The aim of our study was to evaluate expression of platelet-bound SDF-1 and number of CD34(+) progenitor cells in patients with CHF. | 24102302 |
| Ventricular Dysfunction, Left | Stem Cell Exhaustion | Similar to platelet-bound SDF-1 number of CD34(+) progenitor cells was the highest in severe impairment of left ventricular systolic function (mild vs. moderate vs. severe impairment of left ventricular systolic function: mean +- SD: 260.4 +- 177.5 vs. 580.7 +- 340.5 vs. 640.82 +- 370.6, Kruskal-Wallis p < 0.001). | 24102302 |
| Congestive heart failure | Stem Cell Exhaustion | Platelet-bound SDF-1 expression was associated with number of circulating CD34(+) progenitor cells (r = 0.454, p < 0.001) in patients with CHF. | 24102302 |
| Congestive heart failure, Ventricular Dysfunction, Left | Stem Cell Exhaustion | Platelet-bound SDF-1 and CD34(+) progenitor cells are especially increased in patients with severe impairment of left ventricular systolic function in CHF. | 24102302 |
| Intraocular Infection | Stem Cell Exhaustion | Absence of intraocular infections after hematopoietic stem cell transplantation at a single center: the experience with current preventive regimens. | 24102631 |
| Intraocular Infection | Stem Cell Exhaustion | To investigate the prevalence of intraocular infections after allogeneic stem cell transplantation (allo-SCT). | 24102631 |
| Neoplasms | Stem Cell Exhaustion | Identification of brain tumour initiating cells using the stem cell marker aldehyde dehydrogenase. | 24103144 |
| Neoplasms | Stem Cell Exhaustion | This study aimed to evaluate the potential of ALDH as a universal brain tumour initiating cell (BTIC) marker applicable to primary brain tumours and their biological role in maintaining stem cell status. | 24103144 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | CD24 and Nanog identify stem cells signature of ovarian epithelium and cysts that may develop to ovarian cancer. | 24103524 |
| Impaired cognition, Multiple Myeloma | Stem Cell Exhaustion | Acute cognitive impairment in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplant. | 24105672 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Few studies have examined the acute effects of autologous hematopoietic stem cell transplantation (Au-HSCT) on the neuropsychological functioning of patients with multiple myeloma (MM). | 24105672 |
| Ischemia | Stem Cell Exhaustion | HIF-prolyl hydroxylase 2 inhibition enhances the efficiency of mesenchymal stem cell-based therapies for the treatment of critical limb ischemia. | 24105925 |
| PAFAH1B1 wt Allele, Hematological Disease, Dysplasia, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Myelodysplastic syndrome (MDS) is a heterogeneous clonal disorder of hematopoietic stem cells that occurs in elderly subjects and is characterized by dysplasia and ineffective hematopoiesis. | 24106013 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Conditioning regimen including fludarabine, intravenous busulfan (Bx), and 5 mg/kg total dose of rabbit antithymocyte globulin (r-ATG) (FBx-ATG) results in low incidence of graft-versus-host disease (GVHD) and non-relapse mortality (NRM) after allogeneic hematopoietic stem cell transplantation (Allo-HSCT) from HLA-matched related or unrelated donors (MUD). | 24108528 |
| Haiti | Stem Cell Exhaustion | Treatments for HT included autologous stem-cell transplant (auto-SCT) (n = 50), allogeneic SCT (allo-SCT) (n = 18), and treatment without transplant (n = 50). | 24111533 |
| Tebi, Renal carnitine transport defect | Stem Cell Exhaustion | Quantification of HBG mRNA in erythroid progenitor cell cultures from patients with SCD and TI is predictive of their clinical response to HU. | 24112139 |
| Graft-vs-Host Disease, Allogeneic Hematopoietic Stem Cell Transplantation | Stem Cell Exhaustion | To further define the relative impact of immunotherapy and subsequent development of graft-versus-host disease (GVHD) on survival in patients with relapsed acute leukaemia postallogeneic hematopoietic stem cell transplant (SCT), we performed a single-centre retrospective analysis of 32 actively treated patients between 2003 and 2011. | 24112249 |
| Chronic graft-versus-host disease, Acute leukemia | Stem Cell Exhaustion | Immunotherapy following relapse of acute leukaemia after T-cell-replete allogeneic peripheral blood progenitor cell transplantation: importance of new onset chronic graft-versus-host disease. | 24112249 |
| Malignant neoplasm of liver | Stem Cell Exhaustion | PVTT might have the characteristics of presumed liver cancer stem cells. | 24114829 |
| Osteoporosis | Stem Cell Exhaustion | Bone formation in adipose-derived stem cells isolated from elderly patients with osteoporosis: a preliminary study. | 24115596 |
| Osteoporotic Fractures | Stem Cell Exhaustion | We have explored the osteogenic potency of adipose-derived stem cells from osteoporotic patients (opASCs). | 24115596 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Comparison of allogeneic stem cell transplantation and non-transplant approaches in elderly patients with advanced myelodysplastic syndrome: optimal statistical approaches and a critical appraisal of clinical results using non-randomized data. | 24116002 |
| Disease, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Allogeneic stem cell transplantation (ASCT) from related or unrelated donors may cure patients with myelodysplastic syndromes (MDS), a heterogeneous group of clonal stem cell disorders. | 24116002 |
| Pulmonary Complication, Antilymphocyte Serum, PPCS gene | Stem Cell Exhaustion | We report on the use of non-invasive ventilation (NIV) to prevent post-operative pulmonary complications (PPCs) in nine patients affected by ALS enrolled in a phase-1 clinical trial with stem cell transplantation. | 24117131 |
| Lymphoma, Non-Hodgkin | Stem Cell Exhaustion | Engraftment and outcome after autologous stem cell transplantation in plerixafor-mobilized non-Hodgkin's lymphoma patients. | 24118008 |
| Hematologic Neoplasms | Stem Cell Exhaustion | While most commonly seen in the HIV/AIDS population, patients with hematologic malignancies are also at risk following treatment protocols including monoclonal antibodies such as rituximab and after hematopoietic stem cell transplantation. | 24118404 |
| Necrosis, Bone necrosis | Stem Cell Exhaustion | To determine the efficacy of core decompression (CD) technique combined with recombinant morphogenetic proteins, autologous mesenchymal stem cells (MSCs) and xenograft bone substitute into the necrotic lesion of the femoral head on clinical symptoms and on the progression of osteonecrosis of the femoral head. | 24119830 |
| Hemorrhage, Decreased platelet count | Stem Cell Exhaustion | Stem cell transplantation can be associated with significant periods of thrombocytopenia, necessitating platelet transfusions and contributing to the risk of bleeding. | 24120380 |
| Diabetes Mellitus, Insulin-Dependent | Stem Cell Exhaustion | We have investigated the safety and efficacy of autologous bone marrow stem cell transplantation through liver puncture in two patients with recently diagnosed type 1 diabetes mellitus. | 24121994 |
| Diabetes Mellitus, Insulin-Dependent | Stem Cell Exhaustion | Early immunotherapy using autologous adult stem cells reversed the effect of anti-pancreatic islets in recently diagnosed type 1 diabetes mellitus: preliminary results. | 24121994 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Improved relapse-free survival after autologous stem cell transplantation does not translate into better quality of life in chronic lymphocytic leukemia: lessons from the randomized European Society for Blood and Marrow Transplantation-Intergroup study. | 24123244 |
| pidilizumab | Stem Cell Exhaustion | Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: results of an international phase II trial. | 24127452 |
| Lupus Erythematosus, Encephalitis, St. Louis | Stem Cell Exhaustion | Recent studies have shown that allogeneic bone marrow (BM)-mesenchymal stem cell transplantation (MSCT) appears to be effective in systemic lupus erythematosus (SLE) patients and lupus-prone mice, contrary to studies in syngeneic BM-MSCT. | 24130040 |
| Lupus Erythematosus | Stem Cell Exhaustion | Wnt/b-catenin signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients through the p53/p21 pathway. | 24130040 |
| Eruptions, Acute GVH disease, Infestation by Demodex | Stem Cell Exhaustion | This case of Demodex folliculitis mimicking acute GVHD highlights the need for skin biopsy in patients who have undergone a stem cell transplant with eruptions on the head and neck. | 24132559 |
| Eruptions, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | A 46-year-old white woman with a history of Fms-like tyrosine kinase 3 acute myeloid leukemia presented to the dermatology clinic with a 5-day history of a nonpruritic eruption on her face and neck 28 days after undergoing a double umbilical cord blood hematopoietic stem cell transplant (HSCT). | 24132559 |
| Specialty Type - cancer | Stem Cell Exhaustion | HAb18G/CD147 was associated and colocalized with cancer stem cell marker CD44s in lipid rafts. | 24132924 |
| Histogenic Process, Carcinosarcoma | Stem Cell Exhaustion | The histogenesis of carcinosarcoma of the bone remains a matter of controversy, although a multpotential stem cell theory has been proposed. | 24133601 |
| Focal glomerulosclerosis | Stem Cell Exhaustion | Allogeneic mesenchymal stem cell infusion for the stabilization of focal segmental glomerulosclerosis. | 24135082 |
| Focal Segmental Glomerulosclerosis, Not Otherwise Specified | Stem Cell Exhaustion | We describe a cell therapy treatment with human allogeneic bone marrow mesenchymal stem cells (MSC) in a 13-year-old patient developing recurrent FSGS after renal transplantation, which was not responding to conventional therapy. | 24135082 |
| Communicable Diseases, Scedosporium, Acute lymphocytic leukemia | Stem Cell Exhaustion | Here, we report the case of a 21-year-old caucasian female who developed a disseminated infection of Scedosporium prolificans after allogenic stem cell transplantation performed for treatment of relapsed acute lymphoblastic leukaemia. | 24135648 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | [Successful therapy for enteropathy-associated peripheral T-cell lymphoma using high-dose polychemotherapy and autologous hematopoietic stem cell transplantation]. | 24137952 |
| Monomorphic epitheliotropic intestinal T-cell lymphoma | Stem Cell Exhaustion | The article presents a literature review and a case of successful therapy in a 58-year-old patient with type I EATL using the mNHL-BFM-90 protocol and autologous hematopoietic stem cell transplantation. | 24137952 |
| Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | To evaluate the efficiency of extracorporeal photopheresis (ECP) in the treatment of patients with refractory chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 24137966 |
| T-Cell Lymphoma | Stem Cell Exhaustion | High-dose therapy and autologous hematopoietic stem cell transplant in T-cell lymphoma: a single center experience. | 24138331 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | We report here the long-term outcome of autologous stem cell transplant in peripheral T-cell lymphoma (PTCL). | 24138331 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | Forty-three consecutive patients with PTCL diagnosed between 2000 and 2011 were treated with high-dose chemotherapy (HDCT) and autologous stem cell transplant (ASCT) in our center. | 24138331 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | We present an interim analysis of the first prospective study in which Plerixafor was administered on-demand in patients affected by multiple myeloma and lymphoma who received high dose cyclophosphamide or DHAP (dexamethasone, cytarabine, cisplatin) plus G-CSF to mobilize peripheral blood stem cells (PBSC). | 24138497 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Cytogenetic risk grouping by the monosomal karyotype classification is superior in predicting the outcome of acute myeloid leukemia undergoing allogeneic stem cell transplantation in complete remission. | 24138573 |
| Leukemia, Myelocytic, Acute, Chromosome Aberrations | Stem Cell Exhaustion | We retrospectively analyzed the impact of cytogenetic abnormalities grouped according to the monosomal karyotype (MK) classification or the Southwest Oncology/Eastern Cooperative Oncology Group (SWOG/ECOG) definition in 263 patients with acute myeloid leukemia (AML) who underwent allogeneic stem cell transplantation (alloSCT) in complete remission (CR) at our center. | 24138573 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Whole-genome sequencing of clonally expanded hematopoietic stem/progenitor cells (HSPCs) from healthy individuals and a premalignant myelodysplastic syndrome (MDS) sample revealed no X chromosome hypermutation. | 24139898 |
| Lymphoma, Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | High-dose etoposide plus granulocyte colony-stimulating factor as an effective chemomobilization regimen for autologous stem cell transplantation in patients with non-Hodgkin Lymphoma previously treated with CHOP-based chemotherapy: a study from the Consortium for Improving Survival of Lymphoma. | 24141009 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | Endothelial progenitor cells in patients with chronic obstructive pulmonary disease. | 24142520 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | The objective of this study was to compare circulating endothelial progenitor cells in patients with chronic obstructive pulmonary disease to age, sex, and cigarette smoking matched healthy controls. | 24142520 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | In contrast to previous studies, the number of circulating progenitor cells was not reduced in patients with chronic obstructive pulmonary disease compared with carefully matched controls. | 24142520 |
| Pulmonary Emphysema | Stem Cell Exhaustion | It seems unlikely that circulating endothelial progenitor cells or failure of angiogenesis plays a central role in the development of emphysema. | 24142520 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Steroid-refractory graft-versus-host disease is a life-threatening complication after allogeneic stem cell transplantation. | 24142995 |
| Frontotemporal dementia, Antilymphocyte Serum | Stem Cell Exhaustion | Here we sought to study altered molecular events in FTD and ALS by using induced pluripotent stem cell (iPSC) derived patient neurons. | 24143176 |
| Fanconi Anemia | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation in Fanconi anemia: the European Group for Blood and Marrow Transplantation experience. | 24144640 |
| Fanconi Anemia | Stem Cell Exhaustion | Although allogeneic hematopoietic stem cell transplantation (HSCT) remains the only curative treatment for patients with Fanconi anemia (FA), published series mostly refer to single-center experience with limited numbers of patients. | 24144640 |
| Adverse Event Associated with Secondary Malignancy, Chronic graft-versus-host disease | Stem Cell Exhaustion | Age more than 10 years at time of HSCT, clonal evolution as an indication for transplantation, peripheral blood as source of stem cells, and chronic graft-versus-host disease were found to be independently associated with the risk for secondary malignancy. | 24144640 |
| NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Stem Cell Exhaustion | Stem cell self-renewal factors Bmi1 and HMGA2 in head and neck squamous cell carcinoma: clues for diagnosis. | 24145240 |
| Neoplasms | Stem Cell Exhaustion | Both Bmi-1 and Hmga2 are known to promote stem cell self-renewal by negatively regulating the expressions of Ink4a and Arf tumor suppressors. | 24145240 |
| Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Stem Cell Exhaustion | Head and neck squamous cell carcinoma (HNSCC) includes both morphological and functional cellular heterogeneity, as would be expected if it arose from dysregulated stem or progenitor cells as opposed to the simple clonal expansion of a mutated cell; however, stemness molecule expression levels and distribution in HNSCC remain unclear. | 24145240 |
| Amyloidosis | Stem Cell Exhaustion | On multivariate analysis, pooled AL-CRAB and AL-PCMM retained negative prognostic value independent of age, Mayo Clinic AL amyloidosis stage, prior autologous stem-cell transplantation, and difference between the involved and uninvolved free light chain. | 24145344 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | Clinical assessment of anti-viral CD8+ T cell immune monitoring using QuantiFERON-CMV(r) assay to identify high risk allogeneic hematopoietic stem cell transplant patients with CMV infection complications. | 24146744 |
| Zygomycosis, Hematologic Neoplasms | Stem Cell Exhaustion | Mucormycosis is increasingly encountered in immunosuppressed patients, such as those with haematological malignancies or stem cell transplantation. | 24147728 |
| Ameloblastoma | Stem Cell Exhaustion | Expression of the stem cell marker, SOX2, in ameloblastoma and dental epithelium. | 24148099 |
| Neoplasms | Stem Cell Exhaustion | Expression of the transcription factor SOX2 has been previously localized in epithelial stem and progenitor cells in developing teeth as well as in various tumors. | 24148099 |
| Ischemia, diabetic | Stem Cell Exhaustion | Role of serum levels of angiogenic cytokines in assessment of angiogenesis after stem cell therapy of diabetic patients with critical limb ischemia. | 24148204 |
| Parkinson Disease | Stem Cell Exhaustion | Parkinson's disease associated mutations in leucine rich repeat kinase 2 (LRRK2) impair mitochondrial function and increase the vulnerability of induced pluripotent stem cell (iPSC)-derived neural cells from patients to oxidative stress. | 24148854 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Stratification of de novo adult acute myelogenous leukemia with adverse-risk karyotype: can we overcome the worse prognosis of adverse-risk group acute myelogenous leukemia with hematopoietic stem cell transplantation? | 24149098 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Adverse-risk karyotype AML is now treated with intensive chemotherapy followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT) to overcome relapse. | 24149098 |
| Gastric Intestinal-Type Adenocarcinoma | Stem Cell Exhaustion | To investigate expression of stem cell marker Musashi-1 (Msi-1) in relationship to tumorigenesis and progression of intestinal-type gastric cancer (GC). | 24151393 |
| Lupus Erythematosus | Stem Cell Exhaustion | p53/p21 Pathway involved in mediating cellular senescence of bone marrow-derived mesenchymal stem cells from systemic lupus erythematosus patients. | 24151513 |
| Lupus Erythematosus, Adolescent Behavior, Encephalitis, St. Louis | Stem Cell Exhaustion | Our and other groups have found that bone marrow-derived mesenchymal stem cells (BM-MSCs) from systemic lupus erythematosus (SLE) patients exhibited senescent behavior and are involved in the pathogenesis of SLE. | 24151513 |
| Chronic myeloproliferative disorder, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Chronic myeloid leukemia (CML) on the contrary occurs in both young adults and elderly and is a chronic myeloproliferative disease that originates from abnormal pluripotent stem cells and results in involvement of multiple hematopoietic lineages, but predominantly myeloid and less commonly lymphoid. | 24152491 |
| Neoplasms, Glioblastoma | Stem Cell Exhaustion | Glioblastoma multiforme (GBM)-initiating cells (GICs) represent a tumor subpopulation with neural stem cell-like properties that is responsible for the development, progression and therapeutic resistance of human GBM. | 24155920 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | We also examined the effect of AT13387 on putative cancer stem cells (CSC) by 3-D tumor sphere formation assay. | 24156782 |
| Liver carcinoma, Hollings Cancer Center | Stem Cell Exhaustion | Forfeited hepatogenesis program and increased embryonic stem cell traits in young hepatocellular carcinoma (HCC) comparing to elderly HCC. | 24160375 |
| Optic Nerve Hypoplasia | Stem Cell Exhaustion | Failure of stem cell therapy to improve visual acuity in children with optic nerve hypoplasia. | 24160969 |
| Optic Nerve Hypoplasia | Stem Cell Exhaustion | To evaluate the effectiveness of stem cell therapy in improving visual acuity or optic nerve function in children with optic nerve hypoplasia (ONH). | 24160969 |
| Teratoma | Stem Cell Exhaustion | No stem-cell-related teratoma formed and no anti-donor antibodies developed. | 24161821 |
| Chronic granulomatous disease | Stem Cell Exhaustion | Reduced-intensity conditioning and HLA-matched haemopoietic stem-cell transplantation in patients with chronic granulomatous disease: a prospective multicentre study. | 24161820 |
| Graft-vs-Host Disease, Chronic granulomatous disease | Stem Cell Exhaustion | In chronic granulomatous disease allogeneic haemopoietic stem-cell transplantation (HSCT) in adolescents and young adults and patients with high-risk disease is complicated by graft-failure, graft-versus-host disease (GVHD), and transplant-related mortality. | 24161820 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | Autologous stem cell transplantation after conditioning with yttrium-90 ibritumomab tiuxetan plus BEAM in refractory non-Hodgkin diffuse large B-cell lymphoma: results of a prospective, multicenter, phase II clinical trial. | 24162789 |
| Retinal Diseases, Vascular Diseases | Stem Cell Exhaustion | The generation of vascular progenitors (VPs) from human induced pluripotent stem cells (hiPSCs) has great potential for treating vascular disorders such as ischemic retinopathies. | 24163065 |
| Failure, Myelodysplastic-Myeloproliferative Diseases | Stem Cell Exhaustion | Relapse is the major cause of treatment failure after allogeneic stem-cell transplantation (AHSCT) for patients with myelodysplastic syndrome/myeloproliferative syndrome neoplasms (MDS/MPN). | 24164563 |
| Aggressive course, Post-transplant lymphoproliferative disorder, Communicable Diseases | Stem Cell Exhaustion | Post-transplant lymphoproliferative disorder (PTLD) is a well-recognized aggressive disease commonly associated with Epstein-Barr virus (EBV) infection after hematopoietic stem cell transplantation (HSCT). | 24169729 |
| Aggressive Non-Hodgkin Lymphoma | Stem Cell Exhaustion | The efficacy of autologous stem-cell transplantation during the first remission in patients with diffuse, aggressive non-Hodgkin's lymphoma classified as high-intermediate risk or high risk on the International Prognostic Index remains controversial and is untested in the rituximab era. | 24171516 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | While current treatment for acute myeloid leukemia is characterized by high response rates, patients' long-term outcome is still disappointing, due to frequent relapse and ineligibility of the often elderly patients for stem cell transplantation approaches. | 24175978 |
| Prostate carcinoma | Stem Cell Exhaustion | Atorvastatin inhibited Rho-associated kinase 1 (ROCK1) and focal adhesion kinase (FAK) mediated adhesion and differentiation of CD133+CD44+ prostate cancer stem cells. | 24177008 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | These associations remained after correction for factors known to affect progenitor cell levels including age, smoking status, the use of statin medications and the presence of coronary artery disease. | 24182349 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | Circulating hematopoietic progenitor cells are decreased in COPD. | 24182349 |
| Chronic Obstructive Airway Disease, Pulmonary Emphysema | Stem Cell Exhaustion | The goal of this study was to measure circulating levels of endothelial progenitor cells (EPCs) and hematopoietic progenitor cells (HPCs) in subjects with COPD and to determine if progenitor levels correlated with disease severity and the presence of emphysema. | 24182349 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | We present the results of a novel conditioning regimen in multiple myeloma (MM) patients undergoing tandem autologous stem cell transplant (ASCT). | 24182816 |
| Prostate carcinoma | Stem Cell Exhaustion | Expression of prostate stem cell antigen (PSCA) in prostate cancer: a tissue microarray study of Iranian patients. | 24183365 |
| Prostate carcinoma, prostate stem cell antigen | Stem Cell Exhaustion | Proteins expressed in prostate cancer, including prostate stem cell antigen (PSCA), have been investigated as biomarkers for diagnosis and therapy of prostate cancer. | 24183365 |
| Bacteremia, Thrombosis | Stem Cell Exhaustion | Incidence of and risk factors for persistent gram-positive bacteraemia and catheter-related thrombosis in haematopoietic stem cell transplantation. | 24185587 |
| Multiple Myeloma | Stem Cell Exhaustion | Phase 2 trial of intravenously administered plerixafor for stem cell mobilization in patients with multiple myeloma following lenalidomide-based initial therapy. | 24185588 |
| Multiple Myeloma | Stem Cell Exhaustion | Initial therapy of multiple myeloma with lenalidomide-based regimens can compromise stem cell collection, which can be overcome with the addition of plerixafor. | 24185588 |
| Fibrosis Assessment, leukemia | Stem Cell Exhaustion | Bone marrow fibrosis predicted an inferior overall survival and leukemia event-free survival for patients who received no hematopoietic stem cell transplant in univariate and multivariate analysis. | 24186132 |
| bone marrow fibrosis | Stem Cell Exhaustion | Eleven patients with bone marrow fibrosis and 32 control group patients underwent hematopoietic stem cell transplant; and bone marrow fibrosis was an independent risk for an inferior overall survival but not leukemia-free survival. | 24186132 |
| Myeloid, Histiocytosis, Langerhans-Cell, Acute leukemia | Stem Cell Exhaustion | Furthermore, these cases of acute myeloid or acute leukemia of ambiguous lineage with Langerhans cell histiocytosis share some unique features suggesting a common underlying neoplastic hematopoietic stem cell. | 24186134 |
| Hematologic Neoplasms, Neoplasms, Immunocompromised Host | Stem Cell Exhaustion | The most severely immunocompromised patients are those who have been diagnosed with a hematologic malignancy, solid organ tumor, or who have other conditions that require immunosuppressive therapies and/or solid organ or stem cell transplants. | 24186906 |
| Stricture of artery, Cerebrovascular accident | Stem Cell Exhaustion | Higher numbers of circulating endothelial progenitor cells in stroke patients with intracranial arterial stenosis. | 24188156 |
| Atherosclerosis | Stem Cell Exhaustion | Numbers of circulating endothelial progenitor cells (cEPCs) are associated with atherosclerosis. | 24188156 |
| Paroxysmal nocturnal hemoglobinuria, Hemolysis (lab result), Hemoglobinuria, CTCAE 3.0 | Stem Cell Exhaustion | Paroxysmal nocturnal hemoglobinuria (PNH) is a hemolytic, clonal and acquired disorder of the hematopoietic stem cell with a deficiency of all glycophosphatidyl-inositol (GPI) linked proteins. | 24188430 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | The role of interim fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) to guide use of upfront high dose chemotherapy (HDCT) and autologous stem cell transplant (ASCT) for patients with poor prognosis DLBCL is unproven. | 24188476 |
| Ductal Breast Carcinoma | Stem Cell Exhaustion | Clinicopathological analysis of breast ductal carcinoma in situ with ALDH1-positive cancer stem cells. | 24192633 |
| Noninfiltrating Intraductal Carcinoma, Specialty Type - cancer, Ductal Breast Carcinoma | Stem Cell Exhaustion | The aim of this study was to elucidate the clinicopathological characteristics of breast ductal carcinomas in situ (DCIS) with aldehyde dehydrogenase 1 (ALDH1)-positive cancer stem cells (CSCs). | 24192633 |
| Herpes Simplex Infections | Stem Cell Exhaustion | Transduction of SV40 and herpes simplex virus thymidine kinase-IRES-green fluorescent protein (TK-GFP) did not cause significant change in the stem cell properties of hfBMSCs. | 24199592 |
| Malignant neoplasm of brain, Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells have been isolated from malignant brain tumors and it is widely believed they arise from transformed endogenous stem cells. | 24199814 |
| Thrombophilia, Hemolysis (biological function), Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0, Non-Malignant | Stem Cell Exhaustion | Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired, nonmalignant disorder of hematopoietic stem cells characterized by hemolysis, diminished hematopoiesis, and thrombophilia. | 24200143 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Elevated levels of serum ferritin have been documented to be an adverse prognostic factor in patients with hematologic malignancies undergoing hematopoietic stem cell transplantation. | 24200518 |
| Neoplasms, Specialty Type - cancer, Squamous cell carcinoma of esophagus | Stem Cell Exhaustion | In this study, we isolated cancer stem-like cells from an esophageal squamous cell carcinoma cell line EC109 based on aldehyde dehydrogenase 1A1 (ALDH1A1), and found that ALDH1A1(high) cells possessed the capacities of self-renewal, differentiation and tumor initiation, indications of stem cell properties. | 24201124 |
| Chronic myeloproliferative disorder, Primary Myelofibrosis | Stem Cell Exhaustion | Allogeneic stem cell transplantation for myelofibrosis with leukemic transformation: a study from the Myeloproliferative Neoplasm Subcommittee of the CMWP of the European Group for Blood and Marrow Transplantation. | 24201159 |
| Primary Myelofibrosis, Acute leukemia | Stem Cell Exhaustion | We identified 46 of 1048 myelofibrosis patients in the European Group for Blood and Marrow Transplantation registry who received allogeneic stem cell transplantation for acute leukemia evolving from myelofibrosis. | 24201159 |
| Primary Myelofibrosis, leukemia | Stem Cell Exhaustion | Allogeneic stem cell transplantation can cure myelofibrosis patients transformed to leukemia. | 24201159 |
| Glioblastoma Multiforme Pathway, Astrocytoma | Stem Cell Exhaustion | Nestin, a neural stem cell marker, was specifically expressed in astrocytoma lineage cells in glioma tissue. | 24202294 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Clinicopathological significance of expression of nestin, a neural stem/progenitor cell marker, in human glioma tissue. | 24202294 |
| Acute leukemia | Stem Cell Exhaustion | Increased hs-cTnT levels occur in a significant proportion of adult survivors of childhood acute leukaemias and are associated with larger cumulative anthracycline dose received, history of leukaemic relapse, stem cell transplant, and cardiac irradiation, genetic variants in free radical metabolism, and worse LV myocardial deformation. | 24204736 |
| Specialty Type - cancer, Refractory Cytopenia of Childhood | Stem Cell Exhaustion | The genes identified as differentially methylated implicate pathways involved in metabolism, tissue response to injury, epithelial to mesenchymal transition (EMT), signal transduction and G-protein coupled receptors (GPCRs), cancer, and stem cell regulation in the biology of RCC. | 24204800 |
| Specialty Type - cancer | Stem Cell Exhaustion | Human bone marrow mesenchymal stem cells induce collagen production and tongue cancer invasion. | 24204919 |
| Secondary Neoplasm, Carcinoma | Stem Cell Exhaustion | Carcinoma-associated fibroblasts, bone marrow-derived multipotent mesenchymal stem cells (BMMSCs), and inflammatory cells can all affect the composition of TME leading to changes in proliferation, invasion and metastasis formation of carcinoma cells. | 24204919 |
| Thrombosis | Stem Cell Exhaustion | Cordocytes-stem cells cooperation in the human brain with emphasis on pivotal role of cordocytes in perivascular areas of broken and thrombosed vessels. | 24205927 |
| Vascular System Injuries | Stem Cell Exhaustion | This is the first cytohistopathological study which illustrates and explains some facets of cordocytes-stem cells cooperation around the vessels of human brain with emphasis on the fundamental role of cordocytes in response to vascular injuries. | 24205927 |
| leukemia, B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 | Stem Cell Exhaustion | Improving results of autologous stem cell transplantation for Philadelphia-positive acute lymphoblastic leukaemia in the era of tyrosine kinase inhibitors: a report from the Acute Leukaemia Working Party of the European Group for Blood and Marrow Transplantation. | 24210524 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Guidelines for the management of symptomatic multiple myeloma (MM) recommend upfront autologous stem cell transplantation (ASCT) for transplant-eligible patients. | 24210724 |
| Allogeneic Hematopoietic Stem Cell Transplantation, herpesvirus 3, human | Stem Cell Exhaustion | Prophylactic role of long-term ultra-low-dose acyclovir for varicella zoster virus disease after allogeneic hematopoietic stem cell transplantation. | 24211377 |
| varicella zoster, herpesvirus 3, human | Stem Cell Exhaustion | To evaluate the prophylactic role of long-term ultra-low-dose acyclovir for varicella zoster virus (VZV) disease after allogeneic hematopoietic stem cell transplantation (HSCT). | 24211377 |
| Amyloidosis | Stem Cell Exhaustion | The combination of oral melphalan and dexamethasone is considered standard therapy for patients with light-chain amyloidosis ineligible for autologous stem cell transplantation. | 24213149 |
| Lupus Erythematosus, HIV Infections | Stem Cell Exhaustion | The incidence of HZ was highest among patients with bone marrow or stem cell transplant (43.03 %) followed by solid organ transplant, human immunodeficiency virus infection, and systemic lupus erythematosus [95 % confidence interval (CI) 15.19-17.41 %]. | 24214127 |
| Chronic Lymphocytic Leukemia, Chronic graft-versus-host disease | Stem Cell Exhaustion | High incidence of chronic graft-versus-host disease after myeloablative allogeneic stem cell transplantation for chronic lymphocytic leukemia in Sweden: graft-versus-leukemia effect protects against relapse. | 24214180 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (allo-SCT) is a potentially curative treatment option for eligible patients with chronic lymphocytic leukemia (CLL). | 24214180 |
| Multiple Myeloma | Stem Cell Exhaustion | High incidence of post-transplant cytomegalovirus reactivations in myeloma patients undergoing autologous stem cell transplantation after treatment with bortezomib-based regimens: a survey from the Rome transplant network. | 24215479 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | The incidence of cytomegalovirus (CMV) reactivations in patients with multiple myeloma (MM) receiving autologous stem cell transplantation (ASCT) is relatively low. | 24215479 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Safety and effectiveness of the Genous(tm) endothelial progenitor cell-capture stent in the first year following ST-elevation acute myocardial infarction: A single center experience and review of the literature. | 24216000 |
| Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Long-term outcomes of alemtuzumab-based reduced-intensity conditioned hematopoietic stem cell transplantation for myelodysplastic syndrome and acute myelogenous leukemia secondary to myelodysplastic syndrome. | 24216184 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (HSCT) with reduced-intensity conditioning (RIC) offers a potential cure for patients with myelodysplastic syndrome (MDS) who are ineligible for standard-intensity regimens. | 24216184 |
| PAFAH1B1 wt Allele, Malignant Neoplasms, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Myelodysplastic syndromes (MDS) are age-dependent stem cell malignancies that share biological features of activated adaptive immune response and ineffective hematopoiesis. | 24216507 |
| CLU protein, human | Stem Cell Exhaustion | BM biopsies were obtained from patients with CLI (n=33) included in the Rejuvenating Endothelial Progenitor Cells via Transcutaneous Intra-arterial Supplementation (JUVENTAS) trial (NCT00371371) and controls (n=12). | 24218170 |
| Multiple Myeloma | Stem Cell Exhaustion | Differential humoral responses against heat-shock proteins after autologous stem cell transplantation in multiple myeloma. | 24218189 |
| Monoclonal Gammopathy of Undetermined Significance, Gammopathy | Stem Cell Exhaustion | The aim of the present study was to ascertain the serum antibody levels against three HSP (60, 70 and 90) by ELISA in patients with MM in complete remission after autologous stem cell transplantation (ASCT), with or without OB, and compare them with those patients with stable gammopathy of undetermined significance (MGUS) and healthy controls. | 24218189 |
| Lymphohistiocytosis, Hemophagocytic | Stem Cell Exhaustion | The hemophagocytic syndrome(HPS) after the hematopoietic stem cell transplantation(SHCT) may be triggered by the reactivation of virus such as Epstein-Barr virus (EBV) or cytomegalovirus (CMV) under immunosuppressive state. | 24218764 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Morphology, differentiation and adhesion molecule expression changes of bone marrow mesenchymal stem cells from acute myeloid leukemia patients. | 24220608 |
| Rheumatoid Arthritis | Stem Cell Exhaustion | Effect of therapeutic inhibition of TNF on circulating endothelial progenitor cells in patients with rheumatoid arthritis. | 24222719 |
| Rheumatoid Arthritis | Stem Cell Exhaustion | Low circulating endothelial progenitor cells (EPCs) have been described in many conditions associated with increased cardiovascular risk, including RA. | 24222719 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Acute myeloid leukemia (AML) is believed to arise from leukemic stem-like cells (LSC) making understanding the biological differences between LSC and normal stem cells (HSC) or common myeloid progenitors (CMP) crucial to understanding AML biology. | 24223100 |
| Multiple Myeloma | Stem Cell Exhaustion | Upregulation of miR-135b is involved in the impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients. | 24223191 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Previous studies have demonstrated that mesenchymal stem cells from multiple myeloma (MM) patients (MM-hMSCs) display a distinctive gene expression profile, an enhanced production of cytokines and an impaired osteogenic differentiation ability compared to normal donors (ND-hMSCs). | 24223191 |
| Autistic Disorder | Stem Cell Exhaustion | Etomidate with or without flumazenil anesthesia for stem cell transplantation in autistic children. | 24225126 |
| Autistic Disorder | Stem Cell Exhaustion | Forty autistic children aged 2-12, who were scheduled for stem cell transplantation via lumbar puncture under anesthesia, were randomized for a double-blind study. | 24225126 |
| Autistic Disorder | Stem Cell Exhaustion | Etomidate resulted in stable hemodynamic responses and relatively less adverse effects, and flumazenil antagonized the anesthetic effect of etomidate; thus, etomidate with flumazenil is suitable for performing stem cell transplantation in autistic children. | 24225126 |
| Autistic Disorder | Stem Cell Exhaustion | The aim of this study was to investigate etomidate administration with or without flumazenil in autistic children who underwent intrathecal transplantation of stem cells by lumbar puncture. | 24225126 |
| Intravascular hemolysis, Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0 | Stem Cell Exhaustion | Paroxysmal nocturnal hemoglobinuria (PNH), a rare clonal hematopoietic stem cell disorder, is characterized by chronic, uncontrolled complement activation leading to intravascular hemolysis and an inflammatory prothrombotic state. | 24227693 |
| X-linked sideroblastic anemia, Malignant Neoplasms | Stem Cell Exhaustion | ZFX (zinc finger transcription factor, X chromosome-linked) contributes to the maintenance of different types of stem cells and the progression of various cancers. | 24228108 |
| Xerostomia | Stem Cell Exhaustion | Human salivary gland stem cells ameliorate hyposalivation of radiation-damaged rat salivary glands. | 24232257 |
| Infection of foot, diabetic | Stem Cell Exhaustion | Negative-pressure wound therapy induces endothelial progenitor cell mobilization in diabetic patients with foot infection or skin defects. | 24232261 |
| Neoplasms | Stem Cell Exhaustion | Notch signaling plays a role in stem cell biology, tumor formation, angiogenesis, and cell death. | 24238845 |
| Hematopoietic stem cells, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Myelodysplastic syndromes (MDS) are pre-leukaemic haematopoietic stem cell disorders. | 24238921 |
| Hodgkin Disease | Stem Cell Exhaustion | Roughly 70-80% of patients with advanced stage Hodgkin's lymphoma are cured with various first-line and second-line treatments, including ABVD, BEACOPP, and stem-cell transplantation. | 24239220 |
| Retinal Dystrophies, Retinal Degeneration | Stem Cell Exhaustion | Transplantation of human bone marrow mesenchymal stem cells as a thin subretinal layer ameliorates retinal degeneration in a rat model of retinal dystrophy. | 24239509 |
| Hematologic Neoplasms | Stem Cell Exhaustion | In this retrospective single center study of 442 patients with hematologic malignancies, we analyzed prognostic factors for long-term survival after peripheral blood stem cell transplantation from HLA-matched related or unrelated donors. | 24241489 |
| Acute GVH disease, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Intentional donor lymphocyte-induced limited acute graft-versus-host disease is essential for long-term survival of relapsed acute myeloid leukemia after allogeneic stem cell transplantation. | 24241493 |
| Colorectal Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | CD133 has been recently identified as a marker of putative cancer stem cells in colorectal tumors. | 24244031 |
| Specialty Type - cancer | Stem Cell Exhaustion | The ability of cancer stem cells to resist chemotherapy was clinically highlighted; however, whether CD133 expression can predict chemoresistance remains controversial. | 24244031 |
| Liver carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Lin28B is an oncofetal circulating cancer stem cell-like marker associated with recurrence of hepatocellular carcinoma. | 24244607 |
| Specialty Type - cancer, Hollings Cancer Center | Stem Cell Exhaustion | Therefore, we sought to verify oncofetal-stemness characters of Lin28B and test its potential as a circulating cancer stem cell-like marker in adult HCC patients. | 24244607 |
| Neoplasms, Hollings Cancer Center | Stem Cell Exhaustion | In conclusion, the oncofetal gene Lin28B is a potential oncofetal cancer-stem-cell-like circulating tumor cell marker that correlates with HCC recurrence after hepatectomy. | 24244607 |
| Specialty Type - cancer | Stem Cell Exhaustion | It is also reported to be a potential marker for cancer stem cells. | 24244607 |
| Premature coronary artery atherosclerosis | Stem Cell Exhaustion | Early accelerated senescence of circulating endothelial progenitor cells in premature coronary artery disease patients in a developing country - a case control study. | 24245738 |
| Atherosclerosis, Coronary Arteriosclerosis | Stem Cell Exhaustion | The decreased number and senescence of circulating endothelial progenitor cells (EPCs) are considered markers of vascular senescence associated with aging, atherosclerosis, and coronary artery disease (CAD) in elderly. | 24245738 |
| Peripheral Arterial Diseases | Stem Cell Exhaustion | Effect of progenitor cell mobilization with granulocyte-macrophage colony-stimulating factor in patients with peripheral artery disease: a randomized clinical trial. | 24247554 |
| Ischemic cardiomyopathy | Stem Cell Exhaustion | To demonstrate the safety of transendocardial stem cell injection with autologous mesenchymal stem cells (MSCs) and bone marrow mononuclear cells (BMCs) in patients with ischemic cardiomyopathy. | 24247587 |
| physiopathological, Cardiomyopathies | Stem Cell Exhaustion | Transendocardial stem cell injection with MSCs or BMCs appeared to be safe for patients with chronic ischemic cardiomyopathy and LV dysfunction. | 24247587 |
| Ischemic cardiomyopathy | Stem Cell Exhaustion | Transendocardial mesenchymal stem cells and mononuclear bone marrow cells for ischemic cardiomyopathy: the TAC-HFT randomized trial. | 24247587 |
| Cardiomyopathies | Stem Cell Exhaustion | Whether culture-expanded mesenchymal stem cells or whole bone marrow mononuclear cells are safe and effective in chronic ischemic cardiomyopathy is controversial. | 24247587 |
| Coronary heart disease, altretamine/cisplatin/cyclophosphamide protocol | Stem Cell Exhaustion | Through investigating the effect of the angiotensin receptor blocker (ARB) losartan on the number of endothelial progenitor cells (EPCs) and blood flow-mediated endothelium-dependent function (FMD) in the peripheral blood of patients with coronary heart disease (CHD), we found that FMD was improved and the number of circulating EPCs increased in the ARB treatment group (P <0.05). | 24247796 |
| Specialty Type - cancer, Nasopharyngeal carcinoma | Stem Cell Exhaustion | Cancer stem cell characteristics, ALDH1 expression in the invasive front of nasopharyngeal carcinoma. | 24248285 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Additionally, the features of cancer stem cells (CSCs) in the invasive front of tumors and its correlation with EMT also remain elusive. | 24248285 |
| Acute GVH disease | Stem Cell Exhaustion | Serum albumin level predicts survival of patients with gastrointestinal acute graft-versus-host disease after allogeneic stem cell transplantation. | 24248672 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Low serum albumin levels are associated with poorer OS in patients with gut but not skin aGVHD after RIC but not MAC allogeneic stem cell transplantation. | 24248672 |
| Multiple Myeloma | Stem Cell Exhaustion | Importance of achieving stringent complete response after autologous stem-cell transplantation in multiple myeloma. | 24248686 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | To study the impact of achieving stringent complete response (sCR), an increasingly attainable goal, after autologous stem-cell transplantation (ASCT) in patients with multiple myeloma (MM). | 24248686 |
| Lymphoma | Stem Cell Exhaustion | False-Positive [18F]fluorodeoxyglucose-avid lymph nodes on positron emission tomography-computed tomography after allogeneic but not autologous stem-cell transplantation in patients with lymphoma. | 24248697 |
| Lymphoma | Stem Cell Exhaustion | Determine the clinical significance of [(18)F]fluorodeoxyglucose (FDG)-avid lesions in patients with lymphoma treated with stem-cell transplantation. | 24248697 |
| Lymphoma, Specialty Type - cancer | Stem Cell Exhaustion | All patients who underwent stem-cell transplantation for lymphoma at Memorial Sloan-Kettering Cancer Center between January 2005 and December 2009 and had post-transplantation FDG positron emission tomography/computed tomography (PET/CT) examinations were included. | 24248697 |
| Lymphoma | Stem Cell Exhaustion | Of allogeneic stem-cell transplantation recipients, 50 had FDG-avid lesions suggestive of lymphoma, defined as FDG-avidity greater than liver background. | 24248697 |
| Lymphoma | Stem Cell Exhaustion | Twenty percent (21 of 107) of patients with an allogeneic stem-cell transplantation demonstrated FDG-avid lymph nodes up to 1.5 cm in short axis on PET/CT, which did not represent active lymphoma. | 24248697 |
| Lymphoma, Malignant Neoplasms | Stem Cell Exhaustion | After allogeneic stem-cell transplantation of patients with lymphoma, benign FDG-avid <= 1.5 cm lymph nodes can mimic malignancy. | 24248697 |
| MYELODYSPLASTIC SYNDROME, Secondary Acute Myeloid Leukemia | Stem Cell Exhaustion | Long-term follow-up after allogeneic stem cell transplantation in patients with myelodysplastic syndromes or secondary acute myeloid leukemia: a single center experience. | 24249320 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We performed a single center analysis of 60 adult patients (33 males and 27 females) with myelodysplastic syndromes (MDS) or secondary acute myeloid leukemia (AML) who underwent allogeneic hematopoietic stem cell transplantation (HCT) at our institution. | 24249320 |
| Viremia | Stem Cell Exhaustion | Donor T-cell chimerism and early post-transplant cytomegalovirus viremia in patients treated with myeloablative allogeneic hematopoietic stem cell transplant. | 24251680 |
| Communicable Diseases | Stem Cell Exhaustion | Cytomegalovirus (CMV) is a common infection after myeloablative allogeneic hematopoietic stem cell transplant (M-alloHSCT). | 24251680 |
| Sensorineural Hearing Loss (disorder), Dilated Cardiomyopathy Pathway, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | A 19-month-old girl with the A1555G mitochondrial mutation in the 12S ribosomal RNA gene and acute myelogenous leukemia developed dilated cardiomyopathy and bilateral sensorineural hearing loss before undergoing allogeneic stem cell transplantation. | 24252789 |
| fibrogenesis, Fibrosis Assessment | Stem Cell Exhaustion | The portal inflammatory infiltrate may contribute directly to fibrogenesis as well as influence the fate of the DR hepatic progenitor cells (HPCs), regulating the balance between liver repair and fibrosis. | 24254368 |
| diabetic | Stem Cell Exhaustion | Enhanced wound healing, kinase and stem cell marker expression in diabetic organ-cultured human corneas upon MMP-10 and cathepsin F gene silencing. | 24255036 |
| diabetic | Stem Cell Exhaustion | Our purpose was to assess if silencing M10 and CF in organ-cultured diabetic corneas using recombinant adenovirus (rAV)-driven small hairpin RNA (rAV-sh) would normalize slow wound healing, and diabetic and stem cell marker expression. | 24255036 |
| diabetic | Stem Cell Exhaustion | Diabetic, signaling, and putative stem cell markers were studied by immunofluorescence of corneal cryostat sections. | 24255036 |
| diabetic | Stem Cell Exhaustion | Small hairpin RNA silencing of proteinases overexpressed in diabetic corneas enhanced corneal epithelial and stem cell marker staining and accelerated wound healing. | 24255036 |
| emotional dependency, Adult Glioblastoma | Stem Cell Exhaustion | Protective properties of radio-chemoresistant glioblastoma stem cell clones are associated with metabolic adaptation to reduced glucose dependence. | 24260384 |
| Adult Glioblastoma, Neoplasms | Stem Cell Exhaustion | Glioblastoma stem cells (GSC) are a significant cell model for explaining brain tumor recurrence. | 24260384 |
| Polyradiculoneuropathy, Chronic Inflammatory Demyelinating | Stem Cell Exhaustion | Autologous haematopoietic stem cell transplantation: a viable treatment option for CIDP. | 24262917 |
| Polyradiculoneuropathy, Chronic Inflammatory Demyelinating | Stem Cell Exhaustion | Autologous haematopoietic stem cell transplantation (AHSCT) has been performed as a last treatment resort in a few therapy-refractory cases with CIDP. | 24262917 |
| Leukoencephalopathy | Stem Cell Exhaustion | Significant improvement following combination treatment with mefloquine and mirtazapine in a patient with progressive multifocal leukoencephalopathy after allogeneic peripheral blood stem cell transplantation. | 24264833 |
| Hypoxic-Ischemic Encephalopathy | Stem Cell Exhaustion | Therapeutic effect of human umbilical cord mesenchymal stem cells on neonatal rat hypoxic-ischemic encephalopathy. | 24265136 |
| Hypoxic-Ischemic Encephalopathy | Stem Cell Exhaustion | However, the possibility that human umbilical cord Wharton's jelly-derived mesenchymal stem cells (hUCMSCs) can be used to treat neonatal hypoxic-ischemic encephalopathy (HIE) has not yet been investigated. | 24265136 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | There are no systematic data regarding nonmaintained induction for those patients with multiple myeloma (MM) who do not receive consolidative autologous stem cell transplantation. | 24265187 |
| Specialty Type - cancer | Stem Cell Exhaustion | Accumulating evidence suggests that the epigenome serves as the interface between the genome and the environment and that hypermethylation of stem cell polycomb group target genes is an epigenetic hallmark of cancer. | 24265601 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Influence of ex vivo purging with CliniMACS CD34(+) selection on outcome after autologous stem cell transplantation in non-Hodgkin lymphoma. | 24266323 |
| Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | The major limitation of autologous stem cell transplantation (auto-SCT) in non-Hodgkin lymphoma (NHL) is relapse. | 24266323 |
| Amyloidosis | Stem Cell Exhaustion | Autologous stem cell transplant is an effective therapy for carefully selected patients with AL amyloidosis: experience of a single institution. | 24266428 |
| Amyloidosis | Stem Cell Exhaustion | Autologous stem-cell transplant has been widely used to treat patients with AL amyloidosis. | 24266428 |
| Amyloidosis | Stem Cell Exhaustion | In order to define the role of patient selection in stem cell transplantation, we evaluated 78 consecutive AL amyloidosis patients transplanted at our centre. | 24266428 |
| Mucopolysaccharidosis II, Mucopolysaccharidosis I | Stem Cell Exhaustion | All MPS patients had or were receiving treatment: 15 patients (6 MPS I, 9 MPS II) were receiving enzyme replacement therapy (ERT), 9 patients (all MPS I) had received hematopoietic stem cell transplant (HSCT), and 1 patient with MPS I had received HSCT and was receiving enzyme replacement therapy (ERT). | 24268528 |
| Diabetes, Autonomic neuropathy | Stem Cell Exhaustion | Diabetes causes bone marrow autonomic neuropathy and impairs stem cell mobilization via dysregulated p66Shc and Sirt1. | 24270983 |
| Diabetic Autonomic Neuropathy | Stem Cell Exhaustion | Diabetic autonomic neuropathy (DAN) may impact the BM, because the sympathetic nervous system is prominently involved in BM stem cell trafficking. | 24270983 |
| Diabetes, Ischemia, Neuropathy | Stem Cell Exhaustion | We hypothesize that neuropathy of the BM affects stem cell mobilization and vascular recovery after ischemia in patients with diabetes. | 24270983 |
| Autonomic neuropathy, Diabetes | Stem Cell Exhaustion | In conclusion, autonomic neuropathy in the BM impairs stem cell mobilization in diabetes with dysregulation of the life-span regulators p66Shc and Sirt1. | 24270983 |
| Diabetes, Autonomic neuropathy, Ischemia, Landau-Kleffner Syndrome | Stem Cell Exhaustion | Experimental diabetes (streptozotocin-induced and ob/ob mice) or chemical sympathectomy in mice resulted in BM autonomic neuropathy, impaired Lin(-)cKit(+)Sca1(+) (LKS) cell and endothelial progenitor cell (EPC; CD34(+)Flk1(+)) mobilization, and vascular recovery after ischemia. | 24270983 |
| Immune-mediated | Stem Cell Exhaustion | Immune-mediated neuropathies following stem cell transplantation. | 24273223 |
| Immune-mediated neuropathy | Stem Cell Exhaustion | To study the clinical, electrophysiological and pathological characteristics and outcome of immune-mediated neuropathy (IMN) following stem cell transplantation (SCT). | 24273223 |
| Aggressive Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Impact of prior rituximab on outcomes of autologous stem-cell transplantation in patients with relapsed or refractory aggressive B-cell lymphoma: a multicentre retrospective Spanish group of lymphoma/autologous bone marrow transplant study. | 24274082 |
| S100A4 protein, human, Fanconi Anemia | Stem Cell Exhaustion | Reports of oral malignant transformation in Fanconi Anemia after hematopoietic stem cell transplantation (HSCT) are increasing probably because of longer survival rates. | 24274144 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Fatty acid binding protein 7 as a marker of glioma stem cells. | 24274717 |
| Adult Glioblastoma | Stem Cell Exhaustion | Glioblastoma stem cells (GSCs) are thought to be responsible for the recurrence, chemoresistance, and poor prognosis of glioblastoma. | 24274717 |
| Specialty Type - cancer | Stem Cell Exhaustion | This study investigates an expressive helping (EH) intervention designed to harness those benefits by targeting survivorship problems among cancer survivors treated with hematopoietic stem cell transplant. | 24274798 |
| Non-Malignant | Stem Cell Exhaustion | Nonmalignant disease and use of alternative hematopoietic stem cell transplantation were associated with higher risk of PICU admission. | 24276033 |
| Malignant neoplasm of pancreas, Specialty Type - cancer, Adult Glioblastoma | Stem Cell Exhaustion | In laboratory studies, metformin was reported to affect the survival of cancer stem cells (CSCs) in breast and pancreatic cancers and glioblastoma. | 24278407 |
| Secondary malignant neoplasm of pleura | Stem Cell Exhaustion | One patient with unilateral pleural metastases subsequently underwent hematopoietic stem cell transplantation. | 24279977 |
| Myocardial Ischemia | Stem Cell Exhaustion | Circulating endothelial progenitor cells and especially endothelial colony-forming cells (ECFCs) are promising candidate cells for endothelial regenerative medicine of ischemic diseases, but the conditions for an optimal collection from adult blood must be improved. | 24280239 |
| Malignant neoplasm of ovary, Malignant Neoplasms | Stem Cell Exhaustion | In summary, this research provides a plastic ovarian cancer stem cell model and a new understanding of the cross-link between stem cells and cancers.This results show that ovarian CSLCs can be suppressed by levamisole. | 24280306 |
| Specialty Type - cancer | Stem Cell Exhaustion | Spheroid formation is one property of stem cells-such as embryo-derived or neural stem cells-that has been used for the enrichment of cancer stem-like cells (CSLCs). | 24280306 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Stem cell factor SALL4, a potential prognostic marker for myelodysplastic syndromes. | 24283704 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Due to progress in the research of glioma stem cells and the glioma niche, development of an animal model that facilitates the elucidation of the roles of the host tissue and cells is necessary. | 24284913 |
| Glioblastoma Multiforme Pathway, Neoplasms | Stem Cell Exhaustion | Tumors derived from the human glioma stem/progenitor cell line SU3 were subcutaneously implanted in green fluorescent protein nude mice. | 24284913 |
| Glioblastoma Multiforme Pathway, Hemorrhagic, Necrosis, Neoplasms | Stem Cell Exhaustion | Green fluorescent protein nude mouse subcutaneous xenografts not only consistently maintained the high invasiveness and tumorigenicity of glioma stem/progenitor cells, but also consisted of a high concentration of tumor blood vessels and necrotic and hemorrhagic foci. | 24284913 |
| Sample Size Calculation | Stem Cell Exhaustion | The expression of EGFL7 in forearm skin biopsies (n = 16 SSc, n = 10 controls), cultured dermal microvascular endothelial cells (MVECs) (n = 3 SSc, n = 3 controls) and late-outgrowth peripheral blood endothelial progenitor cell (EPC)-derived endothelial cells (n = 15 SSc, n = 8 controls) was investigated by immunofluorescence and Western blotting. | 24286167 |
| Cartilage | Stem Cell Exhaustion | Injectable cultured bone marrow-derived mesenchymal stem cells in varus knees with cartilage defects undergoing high tibial osteotomy: a prospective, randomized controlled clinical trial with 2 years' follow-up. | 24286801 |
| Keratoconus | Stem Cell Exhaustion | Protection of corneal epithelial stem cells prevents ultraviolet A damage during corneal collagen cross-linking treatment for keratoconus. | 24288393 |
| Kidney Diseases, Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation | Stem Cell Exhaustion | [Complete remission of repeated recurrent membranous nephropathy after non-myeloablative allogeneic peripheral blood stem cell transplantation]. | 24288970 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | A 64-year-old man with treatment-related myelodysplastic syndrome (MDS) underwent non-myeloablative allogeneic peripheral blood stem cell transplantation from a fully HLA-matched sibling. | 24288970 |
| Usual Severity Pain, Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Early application of percutaneous vertebroplasty reduces pain without affecting peripheral blood stem cell (PBSC) collection and transplant in newly diagnosed multiple myeloma (MM) patients. | 24289239 |
| Joints | Stem Cell Exhaustion | Safety reporting on implantation of autologous adipose tissue-derived stem cells with platelet-rich plasma into human articular joints. | 24289766 |
| Cessation of life, Edema | Stem Cell Exhaustion | However, swelling of injected joints was common and was thought to be associated with death of stem cells. | 24289766 |
| Cerebrovascular accident | Stem Cell Exhaustion | In the investigator-initiated clinical trial of stem cell therapy for stroke, we are going to include fine-grained evaluation methods and investigate the most suitable technique of rehabilitation for patients after treatment. | 24291920 |
| Cerebral Infarction | Stem Cell Exhaustion | [Rehabilitation for patients with cerebral infarction after transplantation of autologous human mesenchymal stem cells]. | 24291920 |
| Cerebral Infarction | Stem Cell Exhaustion | We participated as physiatrists in Honmou et al's study that designed to assess feasibility and safety of transplantation of autologous human mesenchymal stem cells in patients with cerebral infarction, and tried to detect improvements that were distinguishable from usual course of rehabilitation. | 24291920 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Vorinostat plus tacrolimus and mycophenolate to prevent graft-versus-host disease after related-donor reduced-intensity conditioning allogeneic haemopoietic stem-cell transplantation: a phase 1/2 trial. | 24295572 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Acute graft-versus-host disease (GVHD) remains a barrier to more widespread application of allogeneic haemopoietic stem-cell transplantation. | 24295572 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | We aimed to study the safety and activity of vorinostat, in combination with standard immunoprophylaxis, for prevention of GVHD in patients undergoing related-donor reduced-intensity conditioning haemopoietic stem-cell transplantation. | 24295572 |
| Hematological Disease, Hemopoietic stem cell transplant | Stem Cell Exhaustion | We recruited adults (aged >=18 years) with high-risk haematological malignant diseases who were candidates for reduced-intensity conditioning haemopoietic stem-cell transplantation and had an available 8/8 or 7/8 HLA-matched related donor. | 24295572 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Future studies are needed to assess the effect of vorinostat for prevention of GVHD in broader settings of haemopoietic stem-cell transplantation. | 24295572 |
| Secondary to, Multiple Myeloma | Stem Cell Exhaustion | Secondary MGUS was more common in patients with myeloma who had undergone stem cell transplantation than in those who had not (17 [29.8%] of 57 versus 5 [1.4%] of 352, P < .001). | 24296491 |
| Endothelial Progenitor Cells | Stem Cell Exhaustion | Glycogen synthase kinase-3b inhibition augments diabetic endothelial progenitor cell abundance and functionality via cathepsin B: a novel therapeutic opportunity for arterial repair. | 24296714 |
| Dominica, Diabetes Mellitus | Stem Cell Exhaustion | Progenitor cell therapy is hindered in patients with diabetes mellitus (DM) due to cellular senescence. | 24296714 |
| Dominica | Stem Cell Exhaustion | Thus, we aimed to determine if and how GSK3b inhibitors (GSKi) can improve therapeutic efficacy of endothelial progenitor cells (EPC) from patients with DM. | 24296714 |
| European Organization for Research and Treatment of Cancer, Global Stable Disease in Lymph Nodes, Specialty Type - cancer, leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The European Organisation for Research and Treatment of Cancer (EORTC) and Gruppo Italiano Malattie Ematologiche dell' Adulto (GIMEMA) Leukemia Groups conducted a randomized trial (AML-12; Combination Chemotherapy, Stem Cell Transplant and Interleukin-2 in Treating Patients With Acute Myeloid Leukemia) in 1,942 newly diagnosed patients with AML, age 15 to 60 years, comparing remission induction treatment containing daunorubicin, etoposide, and either standard-dose (SD) cytarabine (100 mg/m(2) per day by continuous infusion for 10 days) or high-dose (HD) cytarabine (3,000 mg/m(2) every 12 hours by 3-hour infusion on days 1, 3, 5, and 7). | 24297940 |
| Burn, CTCAE | Stem Cell Exhaustion | A 56-year-old man with a severe chemical burn was referred to our clinic for the management of total limbal stem cell deficiency. | 24299729 |
| Malignant neoplasm of ovary, Specialty Type - cancer | Stem Cell Exhaustion | Molecular portraits of heterogeneity related to cancer stem cells in human ovarian cancer. | 24300467 |
| Malignant neoplasm of ovary, Specialty Type - cancer | Stem Cell Exhaustion | The aim of this study was to investigate molecular portraits of heterogeneity related to cancer stem cells (CSCs) in human ovarian cancer and to access the value in diagnosis and treatment. | 24300467 |
| diabetic | Stem Cell Exhaustion | Differential MMP-9 activity in CD34+progenitor cell-derived foam cells from diabetic and normoglycemic patients. | 24305990 |
| diabetic | Stem Cell Exhaustion | We analyzed the growth characteristics as well as the M-CSF-release and matrix metalloproteinase (MMP) synthesis from CD34(+) progenitor cell-derived foam cells originating from diabetic and nondiabetic patients. | 24305990 |
| diabetic | Stem Cell Exhaustion | There is evidence that progenitor cells from diabetic and nondiabetic patients have different properties, which may affect the patients' prognosis. | 24305990 |
| diabetic | Stem Cell Exhaustion | CD34(+) progenitor cells from diabetic and nondiabetic patients were isolated and incubated with platelets from healthy volunteers. | 24305990 |
| Hypertensive (finding) | Stem Cell Exhaustion | Effect of olmesartan medoxomil on number and survival of circulating endothelial progenitor cells and calcitonin gene related peptide in hypertensive patients. | 24309489 |
| Endothelium, Vascular, Vascular Diseases | Stem Cell Exhaustion | Injury of vascular endothelium, crucial in vascular disease, is repaired via circulating endothelial progenitor cells (cEPCs). | 24309489 |
| Transglutaminases | Stem Cell Exhaustion | Immunohistochemical staining included Congo red, Oil Red O, periodic acid-Schiff (PAS), Masson's trichrome, transglutaminase-2 (TG-2), mesenchymal stem cell markers CD29 (b-1-integrin), and CD34. | 24311926 |
| Rheumatoid Arthritis, Inflammation, Atherosclerosis, Vascular lesions | Stem Cell Exhaustion | To evaluate the association between inflammation, oxidative stress, and circulating progenitor cell (CPC) number and redox equilibrium, vascular lesions and accelerated atherosclerosis in rheumatoid arthritis (RA). | 24313545 |
| Rheumatoid Arthritis, Inflammation | Stem Cell Exhaustion | Circulating progenitor cells in rheumatoid arthritis: association with inflammation and oxidative stress. | 24313545 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | PFS was significantly influenced by CLL duration, beta2-microglobulin, and improved by post-remissional stem cell transplantation. | 24314589 |
| Late Onset Disorders | Stem Cell Exhaustion | Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) resets their identity back to an embryonic age and, thus, presents a significant hurdle for modeling late-onset disorders. | 24315443 |
| Chemosensitivity | Stem Cell Exhaustion | A phase II study of a nonmyeloablative allogeneic stem cell transplant with peritransplant rituximab in patients with B cell lymphoid malignancies: favorably durable event-free survival in chemosensitive patients. | 24315843 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | The aim of this prospective phase II trial was to determine the safety and efficacy of a nonmyeloablative conditioning program incorporating peritransplant rituximab in patients with CD20+ B cell non-Hodgkin lymphoma (B-NHL) receiving an allogeneic stem cell transplant (allo-SCT). | 24315843 |
| Multiple Myeloma | Stem Cell Exhaustion | We conducted a retrospective evaluation of response and survival for 293 patients with multiple myeloma treated since June 2000 with primary thalidomide- or bortezomib-based combinations, of whom 207 patients received intensive therapy supported by autologous blood stem cells within the first year. | 24317125 |
| Neoplasm Metastasis, Hemopoietic stem cell transplant | Stem Cell Exhaustion | Secondary solid tumors that occur after hematopoietic stem cell transplantation (HSCT) are late complications of HSCT. | 24317739 |
| Neoplasms | Stem Cell Exhaustion | It means that circulating bone marrow-derived stem cells (BMDCs) including hematopoietic stem cells include the stem cells of many tissue types and the precancerous cells of many solid tumors. | 24317739 |
| Squamous cell carcinoma of esophagus | Stem Cell Exhaustion | This study suggests that BMDC-derived cells include the stem cells of esophageal epidermis and the precancerous cells of esophageal SCC and can differentiate into esophageal epithelium and esophageal SCC. | 24317739 |
| Have Been Vomiting, Nausea | Stem Cell Exhaustion | Palonosetron and dexamethasone for the prevention of nausea and vomiting in patients receiving allogeneic hematopoietic stem cell transplantation. | 24317849 |
| Have Been Vomiting, Nausea | Stem Cell Exhaustion | The primary aim of this study was to evaluate the efficacy of palonosetron combined with dexamethasone in the prevention of vomiting, and especially nausea, in patients receiving allogeneic stem cell transplantation. | 24317849 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | The study emphasizes the importance of rs4693608 SNP for HPSE gene expression in activated MNCs, indicating a role in allogeneic stem cell transplantation, including postconditioning, engraftment, and GVHD. | 24319286 |
| Neoplasms | Stem Cell Exhaustion | Staining for BerEp4 was positive at the periphery of both neoplasms, suggesting germinative differentiation of the neoplastic cells, whereas staining for the follicular stem-cell marker PHLDA-1 (TDAG51) showed strong focal expression in the tumor cells of both cases. | 24320809 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | In vitro data indicate that low doses of metformin inhibited the self-renewal/proliferation of cancer stem cells (CSC)/TICs in ErbB2-overexpressing breast cancer cells. | 24322659 |
| Infection, leukemia | Stem Cell Exhaustion | Targeted therapy against multi-resistant bacteria in leukemic and hematopoietic stem cell transplant recipients: guidelines of the 4th European Conference on Infections in Leukemia (ECIL-4, 2011). | 24323984 |
| Endometrial Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Epithelial-mesenchymal transition and cancer stem cells in endometrial cancer. | 24324082 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Epithelial-mesenchymal transition (EMT) and cancer stem cells (CSCs) are presumed to be key conditions for malignancy. | 24324082 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Stem cell injections combined with arthroscopic lavage were administered to 30 elderly patients (>=65 years) with knee OA. | 24326779 |
| Degenerative polyarthritis, Usual Severity Pain | Stem Cell Exhaustion | Adipose-derived stem cell therapy for elderly patients with knee OA was effective in cartilage healing, reducing pain, and improving function. | 24326779 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Therefore, adipose-derived stem cell treatment appears to be a good option for OA treatment in elderly patients. | 24326779 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Clinical results and second-look arthroscopic findings after treatment with adipose-derived stem cells for knee osteoarthritis. | 24326779 |
| Osteoarthritis, Knee, Degenerative polyarthritis | Stem Cell Exhaustion | In the present study, the clinical outcomes and second-look arthroscopic findings of intra-articular injection of stem cells with arthroscopic lavage for treatment of elderly patients with knee osteoarthritis (OA) were evaluated. | 24326779 |
| Specialty Type - cancer | Stem Cell Exhaustion | We investigated how cancer stem cell markers change after neoadjuvant therapy and how these markers relate to recurrence. | 24327017 |
| NES gene | Stem Cell Exhaustion | The stem cell marker nestin (NES) is found in dividing cells of developing and regenerating tissues. | 24329895 |
| Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin | Stem Cell Exhaustion | High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (auto-HSCT) is a promising approach for non-Hodgkin's lymphoma (NHL). | 24329982 |
| Lymphoma, Non-Hodgkin, Familial | Stem Cell Exhaustion | High-dose MTX is a powerful regimen component for stem cell mobilization in adult patients with NHL. | 24329982 |
| Lymphoma, Non-Hodgkin | Stem Cell Exhaustion | High-dose methotrexate in the mobilization of hematopoietic stem cells for patients with non-Hodgkin's lymphoma: a twelve-year study in a single center. | 24329982 |
| Down Syndrome | Stem Cell Exhaustion | The effect of imatinib on Ab production was also investigated in human embryonic kidney 293 (HEK293) cells overexpressing the amyloid precursor protein (APP) with the Swedish mutation, in mouse primary cortical neurons and in human Down syndrome embryonic stem-cell-derived cortical neurons. | 24331439 |
| Communicable Diseases | Stem Cell Exhaustion | Comparable humoral response after two doses of adjuvanted influenza A/H1N1pdm2009 vaccine or natural infection in allogeneic stem cell transplant recipients. | 24333120 |
| Hemopoietic stem cell transplant, Communicable Diseases | Stem Cell Exhaustion | The present study evaluated immunogenicity and tolerance of two-dose influenza A/H1N1pdm09 vaccination in allogeneic hematopoietic stem cell transplantation (HSCT) recipients, and compared the vaccine-induced humoral response to that triggered by natural infection in another group of HSCT patients. | 24333120 |
| Endometrial Carcinoma | Stem Cell Exhaustion | In vitro assay confirmed that stem cell factor (SCF), a ligand of CD117, was produced specifically in CD117(+) cells of endometrial cancer, and the colony-forming activity were abrogated by adding anti-SCF antibody, indicating an SCF-dependent growth property. | 24333732 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | Inverse correlation between circulating endothelial progenitor cells with CD34+CD133+ and the severity of coronary atherosclerosis assessed by Syntax score. | 24335569 |
| Atherosclerosis | Stem Cell Exhaustion | The number of endothelial progenitor cells (EPCs) descends when atherosclerosis developed. | 24335569 |
| Inflammation, Coronary Arteriosclerosis | Stem Cell Exhaustion | Effects of clopidogrel therapy on oxidative stress, inflammation, vascular function, and progenitor cells in stable coronary artery disease. | 24336012 |
| Arterial Stiffness, Inflammation, Hyperemia | Stem Cell Exhaustion | We assessed (1) endothelial function as flow-mediated dilation of the brachial artery, (2) arterial stiffness and central augmentation index using applanation tonometry, (3) vascular function as fingertip reactive hyperemia index, (4) inflammation by measuring plasma CD40 ligand and serum high-sensitivity c-reactive protein levels, (5) oxidative stress by measuring plasma aminothiols, and (6) circulating progenitor cells, at baseline and at the end of each 6-week treatment period. | 24336012 |
| Arterial Stiffness | Stem Cell Exhaustion | However, clopidogrel therapy had no effect on endothelial function, arterial stiffness, inflammatory and oxidative stress markers, or progenitor cells. | 24336012 |
| Myeloid Leukemia, Chronic, Ionizing radiation | Stem Cell Exhaustion | The incidence of chronic myeloid leukemia (CML), which is caused by BCR/ABL chimeric oncogene formation in a pluripotent hematopoietic stem cell (HSC), increases with age and exposure to ionizing radiation. | 24337217 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Long-term clinical and molecular remissions in patients with mantle cell lymphoma following high-dose therapy and autologous stem cell transplantation. | 24337447 |
| Medial collateral ligament, Mantle cell lymphoma | Stem Cell Exhaustion | Long-term clinical and molecular remissions in patients with mantle cell lymphoma (MCL) following high-dose therapy (HDT) and autologous stem cell transplantation (ASCT) have been evaluated in only a few studies. | 24337447 |
| B-Cell Lymphomas, Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | High-dose chemotherapy (HDT), together with autologous stem cell transplantation (ASCT), plays an important role in the treatment of diffuse large B cell lymphoma (DLBCL), especially as second-line therapy. | 24338743 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Impact of postremission consolidation chemotherapy on outcome after reduced-intensity conditioning allogeneic stem cell transplantation for patients with acute myeloid leukemia in first complete remission: a report from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation. | 24338939 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The objective of the current study was to investigate the role of postremission consolidation chemotherapy before reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (alloSCT) for patients with acute myeloid leukemia (AML) in first complete remission (CR1). | 24338939 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Of the 789 consecutive patients with AML in CR1 who underwent RIC alloSCT from a human leukocyte antigen-matched sibling or matched unrelated donor peripheral stem cell grafts between 2001 and 2010, 591 patients received at least 1 cycle of consolidation chemotherapy and 198 patients did not receive any consolidation chemotherapy before alloSCT. | 24338939 |
| Vascular System Injuries | Stem Cell Exhaustion | Circulating endothelial cells (CEC) may be a biomarker of vascular injury and pro-thrombotic tendency, while circulating endothelial progenitor cells (CEP) may be an indicator for angiogenesis and vascular remodelling. | 24339944 |
| Ependymal cell | Stem Cell Exhaustion | Substantial ependymal cell loss resulted in reactive gliosis rather than stem cell-mediated regenerative repair of the ventricle lining, and the gliotic regions showed morphologic and phenotypic characteristics similar to those found in aged humans. | 24341850 |
| Multiple Myeloma | Stem Cell Exhaustion | High-dose chemotherapy and autologous stem cell transplantation in multiple myeloma: a single institution experience at All India Institute of Medical Sciences, New Delhi, using non-cryopreserved peripheral blood stem cells. | 24342104 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplantation (AHCT) improves survival in patients with multiple myeloma (MM) but is associated with morbidity and nonrelapse mortality (NRM). | 24342394 |
| Multiple Myeloma | Stem Cell Exhaustion | The effect of gradual increment in rhG-CSF dose on stem cell yields in patients with multiple myeloma mobilized with intermediate dose cyclophosphamide plus rhG-CSF. | 24342458 |
| Peripheral Blood Stem Cells, Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | In this paper, we aimed to present gradual dose increment of rhG-CSF between the third day of mobilization and time to apheresis that is started with 5 mg/kg (from day 3 to day 7) and continued with 10 mg/kg (from day 8 to time to apheresis) for peripheral blood stem cell (PBSC) mobilization in multiple myeloma (MM) patients and its effect on stem cell yield and mobilization success. | 24342458 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | Immunohistochemical expression and prognostic relevance of Bmi-1, a stem cell factor, in epithelial ovarian cancer. | 24342665 |
| Malignant Neoplasms | Stem Cell Exhaustion | Bmi-1 is a stem cell factor implicated in many human malignancies with poor outcome. | 24342665 |
| Medial collateral ligament | Stem Cell Exhaustion | To examine the outcomes of patients with chemotherapy-sensitive mantle-cell lymphoma (MCL) following a first hematopoietic stem-cell transplantation (HCT), comparing outcomes with autologous (auto) versus reduced-intensity conditioning allogeneic (RIC allo) HCT and with transplantation applied at different times in the disease course. | 24344210 |
| Kidney Failure, Chronic, Chronic kidney disease stage 5 | Stem Cell Exhaustion | We present a 29-year-old male with end stage renal disease (ESRD) who was transplanted with HLA 4/6 matched kidney from 51-year-old father in June 2010 preceded by co-infusion of donor-adipose tissue derived mesenchymal stem cells (AD-MSC) and bone marrow derived hematopoietic stem cells (BM-HSC) under non-myeloablative conditioning for deleting rejecting T and B-cells. | 24344734 |
| Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | Putative stem cell markers in non-small-cell lung cancer: a clinicopathologic characterization. | 24346092 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | The cancer stem cell (CSC) theory postulates the existence of a distinct population of undifferentiated cells responsible for tumor initiation and maintenance. | 24346092 |
| Specialty Type - cancer | Stem Cell Exhaustion | Proposed CSC markers are expressed both by cancer cells as well as by benign stem cells. | 24346092 |
| Angina Pectoris | Stem Cell Exhaustion | We investigated atorvastatin reloading effects on endothelial progenitor cell (EPC) count and inflammatory cytokine expression after percutaneous coronary intervention (PCI) in patients with stable angina pectoris who had previously received long-term statin treatments. | 24346155 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Monitoring of acute myeloid leukemia patients after allogeneic stem cell transplantation employing semi-automated CD34+ donor cell chimerism analysis. | 24352219 |
| Malignant Neoplasms | Stem Cell Exhaustion | We investigated the long-term risks for systemic and site-specific cancers in patients who had received autologous bone marrow-derived stromal progenitor cells to treat orthopaedic lesions. | 24352775 |
| Specialty Type - cancer | Stem Cell Exhaustion | This study found no increased cancer risk in patients after application of autologous cell-based therapy using bone marrow-derived stromal progenitor cells either at the treatment site or elsewhere in the patients after an average follow-up period of 12.5 years. | 24352775 |
| Multiple Myeloma | Stem Cell Exhaustion | Oligoclonal and monoclonal bands after single autologous stem cell transplant in patients with multiple myeloma: impact on overall survival and progression-free survival. | 24354684 |
| Multiple Myeloma | Stem Cell Exhaustion | Abstract Recently, the occurrence of oligoclonal and monoclonal bands (OB/MB) unrelated to the original clone has been reported in patients with multiple myeloma who undergo autologous stem cell transplant (ASCT) and/or receive treatment with novel agents. | 24354684 |
| Pneumonia | Stem Cell Exhaustion | The availability of HEPA-filtered rooms and the incidence of pneumonia in patients after haematopoietic stem cell transplantation (HSCT): results from a prospective, multicentre, eastern European study. | 24354726 |
| Pneumonia | Stem Cell Exhaustion | To establish the availability of High Efficiency Particulate Air (HEPA)- and nonHEPA-filtered rooms in eastern European transplant centres and to investigate the impact on incidence of pneumonia and mortality after haematopoietic stem cell transplantation (HSCT). | 24354726 |
| Multiple Myeloma | Stem Cell Exhaustion | Autologous stem cell transplantation for elderly patients with newly diagnosed multiple myeloma in the era of novel agents. | 24356629 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | High-dose therapy (HDT) with autologous stem cell transplantation (ASCT) is considered the standard of care for multiple myeloma (MM) patients <65 years. | 24356629 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | The impact of allogeneic stem cell transplantation on the natural course of poor-risk chronic lymphocytic leukemia as defined by the EBMT consensus criteria: a retrospective donor versus no donor comparison. | 24356631 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | In a single-center retrospective donor versus no-donor comparison, we investigated if allogeneic stem cell transplantation (alloSCT) can improve the dismal course of poor-risk chronic lymphocytic leukemia (CLL). | 24356631 |
| Diabetic foot ulcer | Stem Cell Exhaustion | Role of endothelial progenitor cells and inflammatory cytokines in healing of diabetic foot ulcers. | 24358275 |
| Foot Ulcer | Stem Cell Exhaustion | To evaluate changes in endothelial progenitor cells (EPCs) and cytokines in patients with diabetic foot ulceration (DFU) in association with wound healing. | 24358275 |
| Lymphoma | Stem Cell Exhaustion | [Clinical investigation of refractory lymphoma with HLA-mismatched stem-cell microtransplantation]. | 24360103 |
| Lymphoma | Stem Cell Exhaustion | To explore the efficacy and safety of HLA-mismatched stem-cell microtransplantation in patients with refractory lymphoma. | 24360103 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | All patients received programmed infusions of G-CSF-mobilized HLA-mismatched donor peripheral blood stem cell (G-PBSC) after each cycle of Hyper-CVAD/MA conditioning without graft-versus-host disease (GVHD) prophylaxis. | 24360103 |
| Osteogenesis | Stem Cell Exhaustion | Osteogenic lineage commitment of mesenchymal stem cells from patients with ossification of the posterior longitudinal ligament. | 24361881 |
| Osteogenesis | Stem Cell Exhaustion | Mesenchymal stem cells (MSCs) were isolated from spinal ligaments and shown to play a key role in the process of ectopic ossification. | 24361881 |
| Triclonal gammopathy | Stem Cell Exhaustion | After bone marrow biopsy, MM with triclonal gammopathy was diagnosed and autologous stem cell transplantation was performed. | 24361990 |
| Specialty Type - cancer, Triple-Negative Breast Cancer Finding | Stem Cell Exhaustion | Nuclear localization of cancer stem cell marker CD133 in triple-negative breast cancer: a case report. | 24362879 |
| Neoplasms, Triple-Negative Breast Cancer Finding, Childhood Breast Carcinoma | Stem Cell Exhaustion | It has been recently demonstrated that the detection of stem cell niches in triple-negative (TN) breast cancer may provide good prognostic clues for this tumor. | 24362879 |
| Specialty Type - cancer, Childhood Breast Carcinoma, Ductal Breast Carcinoma | Stem Cell Exhaustion | We investigated the subcellular expression and localization of the cancer stem cell marker CD133 in a TN breast cancer biopsy from a 42-year-old Caucasian woman with a histological diagnosis of high-grade invasive ductal breast carcinoma by immunohistochemistry, flow cytometry and quantitative real-time PCR (qRT-PCR). | 24362879 |
| Liver Failure, Acute | Stem Cell Exhaustion | Proliferation of mouse liver stem/progenitor cells induced by plasma from patients with acute liver failure is modulated by P2Y2 receptor-mediated JNK activation. | 24362969 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Monoclonal antibody targeting of IL-3 receptor a with CSL362 effectively depletes CML progenitor and stem cells. | 24363400 |
| Leukemia, Myelocytic, Acute, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | We evaluated the expression of the interleukin 3 (IL-3) receptor a subunit (CD123), an established marker of acute myeloid leukemia stem cells, on CML LSPCs and the potential of targeting those cells with the humanized anti-CD123 monoclonal antibody CSL362. | 24363400 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Despite the remarkable efficacy of tyrosine kinase inhibitors (TKIs) in eliminating differentiated chronic myeloid leukemia (CML) cells, recent evidence suggests that leukemic stem and progenitor cells (LSPCs) persist long term, which may be partly attributable to cytokine-mediated resistance. | 24363400 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Notably, combination of TKI- and CSL362-induced ADCC caused even greater reduction of CML progenitors and further augmented their preferential elimination over normal hematopoietic stem and progenitor cells. | 24363400 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cells (CSCs) have been defined as 'a cell within a tumor that possesses the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor'. | 24366074 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Patients who are newly diagnosed with acute myeloid leukemia and who are 28 days through 18 years old (n = 1,673) hospitalized any time from initial diagnosis through 9 months following diagnosis or until stem cell transplant. | 24366507 |
| Toxic effect | Stem Cell Exhaustion | Allogeneic stem-cell transplantation (alloSCT) might improve survival at the expense of increased toxicity. | 24366930 |
| Neoplasms | Stem Cell Exhaustion | High-dose caspofungin as a component of combination antifungal therapy in 91 patients with neoplastic diseases and hematopoietic stem cell transplantation: a critical review of short-term and long-term adverse events. | 24366977 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | A total of 45 (49%) patients had undergone stem cell transplantation; 80% received allogeneic grafts and 47% had graft-versus-host disease. | 24366977 |
| Hyperbilirubinemia, Hematologic Neoplasms | Stem Cell Exhaustion | Drug-induced hyperbilirubinemia may pose a potential limitation for continued HD-CSP use in highly susceptible patients with hematologic neoplasms and stem cell transplantation. | 24366977 |
| Aplastic Anemia | Stem Cell Exhaustion | This study was purposed to investigate the safety and effectivity of haploidentical stem cell transplantation for chronic aplastic anemia (CAA) by using two kind of third part cells: umbilical cord derived mesenchymal stem cells (hUC-MSC) and haploidentical umbilical cord blood cells. | 24370041 |
| Aplastic Anemia | Stem Cell Exhaustion | [Transplantation of haploidentical-hematopoietic stem cells combined with two kind of third part cells for chronic aplastic anemia: one case report]. | 24370041 |
| Infection of bloodstream | Stem Cell Exhaustion | Incidence, risk factors, and outcome of bloodstream infections during the pre-engraftment phase in 521 allogeneic hematopoietic stem cell transplantations. | 24372809 |
| Behavioral Symptoms Index Composite Score (BASC-2), Infection of bloodstream | Stem Cell Exhaustion | Bloodstream infection (BSI) after allogeneic hematopoietic stem cell transplantation (HSCT) is a well-known complication during the pre-engraftment phase. | 24372809 |
| Malignant germ cell neoplasm of mediastinum | Stem Cell Exhaustion | High-dose chemotherapy followed by autologous peripheral blood stem cell transplantation for recurrent primary mediastinal malignant germ cell tumor: a case report. | 24373121 |
| Hematological Disease | Stem Cell Exhaustion | Between January 2005 and January 2010, 84 cases of IFDs (39 proven and 45 probable) treated with combo were collected in 20 Hematological Italian Centres, in patients who underwent chemotherapy or allogeneic haematopoietic stem cell transplantation for haematological diseases. | 24373120 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Bone marrow graft-versus-host disease: evaluation of its clinical impact on disrupted hematopoiesis after allogeneic hematopoietic stem cell transplantation. | 24374213 |
| Unknown (origin) (qualifier value) | Stem Cell Exhaustion | Idiopathic cytopenias are frequently observed in patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 24374213 |
| Primary malignant neoplasm | Stem Cell Exhaustion | Adjuvant high-dose chemotherapy with autologous hematopoietic stem cell support for high-risk primary breast cancer: results from the Italian national registry. | 24374214 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | The efficacy of high-dose chemotherapy (HDC) and autologous hemopoietic progenitor cell transplantation (AHPCT) for breast cancer (BC) patients has been an area of intense controversy among the medical oncology community. | 24374214 |
| Neoplasms | Stem Cell Exhaustion | GCC and AMN may share a common tumor stem cell with potential of multiple lineage differentiations. | 24374723 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | Effect of the IL28B Rs12979860 C/T polymorphism on the incidence and features of active cytomegalovirus infection in allogeneic stem cell transplant patients. | 24374819 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | The current study was aimed at investigating whether the single nucleotide polymorphism (SNP) (rs12979860), upstream of the IL28B gene, had any effect on the incidence rate and the features of active CMV infection in the Allogeneic stem cell transplantation setting. | 24374819 |
| Prostate carcinoma | Stem Cell Exhaustion | Validation of stem cell markers in clinical prostate cancer: a6-integrin is predictive for non-aggressive disease. | 24375374 |
| Prostate carcinoma | Stem Cell Exhaustion | Various proteins (a2-integrin, a6-integrin, CD117, CD133, EZH2, OCT3/4) are associated with a prostate cancer stem cell phenotype in cell lines and xenografts. | 24375374 |
| Prostate carcinoma | Stem Cell Exhaustion | Our objective was to investigate expression of stem cell markers in clinical prostate cancer in relation to outcome. | 24375374 |
| Prostate carcinoma | Stem Cell Exhaustion | We validated immunohistochemical expression of stem cell markers in 481 prostate cancer patients and correlated expression with clinicopathologic parameters. | 24375374 |
| Prostate carcinoma | Stem Cell Exhaustion | Expression of a2-integrin and EZH2 in a small fraction of prostate cancer cells is supportive for their role as stem cell marker. | 24375374 |
| Cessation of life, Prostate carcinoma | Stem Cell Exhaustion | Although a6-integrin was not a unique stem cell marker, it was predictive for prostate cancer biochemical and local recurrence, and disease specific death. | 24375374 |
| Prostate carcinoma | Stem Cell Exhaustion | The validity of CD117, CD133, and OCT3/4 as prostate cancer stem cell marker is questionable since these proteins were not expressed in clinical prostate cancer. | 24375374 |
| Prostate carcinoma, Neoplasms | Stem Cell Exhaustion | Stem cells are postulated to mediate prostate cancer progression, and represent a small fraction of the entire tumor. | 24375374 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Allogeneic stem cell transplantation as initial salvage for patients with acute myeloid leukemia refractory to high-dose cytarabine-based induction chemotherapy. | 24375514 |
| Glioblastoma Multiforme Pathway, Glioma, Neoplasms | Stem Cell Exhaustion | To deepen our comprehension on tumor heterogeneity, we dissected the mechanism of interaction between tumor cells and relevant components of the neoplastic environment, isolating, from LGG and high-grade gliomas (HGG), proliferating stem cell lines from both the glioma stroma and, where possible, the neoplasm. | 24375787 |
| Glioma | Stem Cell Exhaustion | Glioma-associated stem cells: a novel class of tumor-supporting cells able to predict prognosis of human low-grade gliomas. | 24375787 |
| Intralymphatic Route of Drug Administration, Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | The aim of this study was to clarify the biological properties of intralymphatic tumors susceptible to the development of lymph node metastasis, with special reference to the expression of cancer initiating/stem cell (CIC/CSC) related markers in cancer cells and the number of infiltrating stromal cells. | 24376714 |
| Heat-Shock Response, Chlamydia | Stem Cell Exhaustion | GroEL1, a heat shock protein 60 of Chlamydia pneumoniae, impairs neovascularization by decreasing endothelial progenitor cell function. | 24376840 |
| Hyperglycemia, Atherosclerosis, Hypertension, CTCAE | Stem Cell Exhaustion | The number and function of endothelial progenitor cells (EPCs) are sensitive to hyperglycemia, hypertension, and smoking in humans, which are also associated with the development of atherosclerosis. | 24376840 |
| leukemia | Stem Cell Exhaustion | On the basis of these findings, we propose that ASP represents a potentially important agent for leukemia stem cell-targeted therapy. | 24377566 |
| leukemia | Stem Cell Exhaustion | Leukemia stem cells (LSCs) play important roles in leukemia initiation, progression and relapse, and thus represent a critical target for therapeutic intervention. | 24377566 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Senescence effects of Angelica sinensis polysaccharides on human acute myelogenous leukemia stem and progenitor cells. | 24377566 |
| Growth arrest | Stem Cell Exhaustion | Here, we report that the hESC lines HUES-7 and -9 carrying multiple chromosomal alterations produce in vitro mesenchymal stem cells (MSCs) that show progressive growth arrest and enter senescence after 15 and 16 passages, respectively. | 24380659 |
| Impaired cognition, Traumatic, Nerve Degeneration | Stem Cell Exhaustion | Intravenous transplants of human adipose-derived stem cell protect the brain from traumatic brain injury-induced neurodegeneration and motor and cognitive impairments: cell graft biodistribution and soluble factors in young and aged rats. | 24381292 |
| Cardiotoxicity | Stem Cell Exhaustion | Assessment and comparison of acute cardiac toxicity during high-dose cyclophosphamide and high-dose etoposide stem cell mobilization regimens with N-terminal pro-B-type natriuretic peptide. | 24382557 |
| HD Term Type | Stem Cell Exhaustion | This study was undertaken to prospectively evaluate and compare the acute effect of high-dose (HD), cyclophosphamide (CY) and HD etoposide (ET) on cardiac function assessed by plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients undergoing stem-cell mobilization. | 24382557 |
| Cardiotoxicity, HD Term Type | Stem Cell Exhaustion | Our results suggest that stem cell mobilization with HD CY and HD ET cause acute cardiac toxicity mediated by neurohumoral activation, which was detected by the increases in cardiac biomarker NT-proBNP, and as a matter of fact cardiotoxicity of HD ET seems to be more potent than those exhibited by HD CY. | 24382557 |
| Parainfluenza virus | Stem Cell Exhaustion | DAS181 treatment of hematopoietic stem cell transplant patients with parainfluenza virus lung disease requiring mechanical ventilation. | 24383501 |
| Parainfluenza | Stem Cell Exhaustion | Parainfluenza infection is a cause of significant morbidity and mortality in allogeneic hematopoietic stem cell transplant (HSCT) patients. | 24383501 |
| Lymphoma | Stem Cell Exhaustion | When excluding patients who returned for chemotherapy, patients with lymphoma who were male, had undergone hematopoietic stem cell transplantation, and had a creatinine level >= 1.3 mg/dL demonstrated increased risk for return to the primary acute care service. | 24384360 |
| Colorectal Carcinoma, Intestinal Cancer | Stem Cell Exhaustion | The recently suggested intestinal cancer stem cell marker DCLK1 is an epigenetic biomarker for colorectal cancer. | 24384857 |
| Colorectal Carcinoma, Intestinal Cancer | Stem Cell Exhaustion | Recently, Dclk1 expression was identified to be an intestinal cancer stem cell specific biomarker in mouse models, implicating a potential role for targeting the DCLK1-postive cancer cells as a treatment for colorectal cancer. | 24384857 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | This therapy would at best affect the cancer stem cell population, but will, based on the present results, not be efficient to treat the bulk of the tumor. | 24384857 |
| Specialty Type - cancer, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Studies on microRNAs that are correlated with the cancer stem cells in chronic myeloid leukemia. | 24385111 |
| Specialty Type - cancer, Neoplasms, Secondary Neoplasm, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Accumulating data indicate that cancer stem cells play an important role in tumorigenesis and are underlying cause of tumor recurrence and metastasis, specifically in chronic myeloid leukemia (CML). | 24385111 |
| Specialty Type - cancer, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | We aim to detect the miRNAs that are correlated with the cancer stem cells in CML to provide theoretical basis for clinical application. | 24385111 |
| Amyloidosis | Stem Cell Exhaustion | Induction therapy with bortezomib and dexamethasone followed by autologous stem cell transplantation versus autologous stem cell transplantation alone in the treatment of renal AL amyloidosis: a randomized controlled trial. | 24386911 |
| Amyloidosis | Stem Cell Exhaustion | Although the use of bortezomib alone and in combination with steroids has shown efficacy in AL amyloidosis, its role in combination with high-dose melphalan and autologous stem cell transplantation (HDM/SCT) is unknown. | 24386911 |
| Thrombocytosis, Polycythemia Vera, Primary Myelofibrosis, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation in patients with polycythemia vera or essential thrombocythemia transformed to myelofibrosis or acute myeloid leukemia: a report from the MPN Subcommittee of the Chronic Malignancies Working Party of the European Group for Blood and Marrow Transplantation. | 24389309 |
| Thrombocytosis, Polycythemia Vera | Stem Cell Exhaustion | Allogeneic stem cell transplantation is currently the only potentially curative treatment for advanced polycythemia vera or essential thrombocythemia. | 24389309 |
| Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | These results suggest that the GBM-HSF cell line will provide a good model to study the properties of cancer stem cells and metastasis. | 24390806 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Immunohistochemical analysis showed that 80.9% of the tumor cells were positive for CD133, a cancer stem cell marker. | 24393908 |
| Specialty Type - cancer | Stem Cell Exhaustion | This case illustrates a possible relationship between cancer stem cells and chemoresistance. | 24393908 |
| Liver Dysfunction | Stem Cell Exhaustion | Transient liver function abnormality following treatment with rabbit antithymocyte globulin for nonmyeloablative hematopoetic stem cell transplant: two case reports. | 24395543 |
| Fanconi Anemia | Stem Cell Exhaustion | Radiologic differences between bone marrow stromal and hematopoietic progenitor cell lines from Fanconi Anemia (Fancd2(-/-)) mice. | 24397476 |
| Blast Phase, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Chronic myeloid leukemia is a clonal expansion of hematopoietic progenitor cells characterized by exaggerated proliferation of granulocytic lineage, with chronic phase, accelerated phase and blast crisis. | 24399014 |
| Allogeneic Hematopoietic Stem Cell Transplantation, Post-transplant lymphoproliferative disorder | Stem Cell Exhaustion | Post-transplant lymphoproliferative disease after allogeneic hematopoietic stem cell transplantation: a single-center experience. | 24399278 |
| Post-transplant lymphoproliferative disorder | Stem Cell Exhaustion | Post-transplant lymphoproliferative disease (PTLD) is a rare and serious complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT) or solid organ transplantation. | 24399278 |
| Hematopoietic Stem Cell Mobilization, Lymphoma | Stem Cell Exhaustion | Chemomobilization with high-dose etoposide and G-CSF results in effective and safe stem cell collection in heavily pretreated lymphoma patients: report from a single institution study and review. | 24400988 |
| Lymphoma | Stem Cell Exhaustion | The optimal mobilization strategy prior to autologous stem cell transplantation (auto-SCT) for patients with lymphoma is yet to be determined. | 24400988 |
| Hematopoietic Stem Cell Mobilization, Lymphoma | Stem Cell Exhaustion | We conclude that HD etoposide and G-CSF chemomobilization appear to result in effective, tolerable, and safe stem cell collection in the majority of heavily pretreated lymphoma patients. | 24400988 |
| Alzheimers Disease | Stem Cell Exhaustion | Stem cell derived basal forebrain cholinergic neurons from Alzheimer's disease patients are more susceptible to cell death. | 24401693 |
| Up | Stem Cell Exhaustion | Induced pluripotent stem cells (iPSCs) derived from patients with AD as well as from normal controls could be efficiently differentiated into neurons with characteristics of BFCNs. | 24401693 |
| Adenoma | Stem Cell Exhaustion | Our results suggest that the pituitary stem cell marker GFRa2 is under-expressed in functioning adenomas and over-expressed in NFAs, specifically gonadotropinomas. | 24402129 |
| Specialty Type - cancer | Stem Cell Exhaustion | During EMT, cancer cells acquire stem cell properties. | 24402192 |
| Colorectal Carcinoma | Stem Cell Exhaustion | We aimed to demonstrate the clinical significance of EMT and the stem cell phenotype in colorectal cancer. | 24402192 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | In addition to being a highly specific marker for AML diagnosis (positive predictive value 100%; sensitivity 86.1%; negative predictive value 89.4%), we show that AWT1 hypermethylation also discriminates patients that relapse from those achieving complete remission after hematopoietic stem cell transplantation, with similar efficiency to WT1 expression profiling. | 24405639 |
| Hepatocellular, Neoplasms | Stem Cell Exhaustion | Tumor cells express both biliary and hepatocellular markers by immunohistochemistry, and may also express progenitor cell and stem cell markers. | 24407728 |
| Liver and Intrahepatic Biliary Tract Carcinoma, Carcinogenic Chlorinated Hydrocarbon, Experimental Organism Malignant Hepatocholangiocellular Carcinoma, Genotype | Stem Cell Exhaustion | Combined hepatocellular-cholangiocarcinoma (CHC), also referred to as primary liver carcinoma (PLC) with biphenotypic differentiation, is an increasingly recognized subtype of malignant PLC encompassing varying morphologic forms thought to arise either from progenitor cell lineage or dedifferentiation of mature liver cells. | 24407728 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | In ovarian cancer, CD44+/CD117+ stem cells, also known as cancer-initiating cells (CICs), are highly proliferative and invasive. | 24408020 |
| Toxic effect, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Finally, we demonstrated that TTT-3002 is cytotoxic to leukemic blasts isolated from FLT3/ITD-expressing AML patients, while displaying minimal toxicity to normal hematopoietic stem/progenitor cells from healthy blood and bone marrow donors. | 24408321 |
| Diplopia | Stem Cell Exhaustion | There was no limbal stem cell deficiency, symblepharon, or diplopia noted in either group. | 24411578 |
| Neurologic Manifestations | Stem Cell Exhaustion | [Efficacy of autologous peripheral blood stem cell transplantation (auto-PBSCT) on the neuropathic manifestations in POEMS syndrome]. | 24411685 |
| Peripheral Nervous System Diseases | Stem Cell Exhaustion | The efficacy of autologous peripheral blood stem cell transplantation (auto-PBSCT) reported in case series has been mainly based on hematologic criteria and clinical recovery of peripheral neuropathy dysfunctions but has not been specifically evaluated. | 24411685 |
| Malignant neoplasm of kidney | Stem Cell Exhaustion | Kidney cancer cells secrete IL-8 to activate Akt and promote migration of mesenchymal stem cells. | 24412633 |
| Specialty Type - cancer | Stem Cell Exhaustion | Mesenchymal stem cells (MSCs) are multipotent adult stem cells that have the capability of homing to cancer cells. | 24412633 |
| Specialty Type - cancer, Secondary Neoplasm, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Stem Cell Exhaustion | Cancer stem cells: mediators of tumorigenesis and metastasis in head and neck squamous cell carcinoma. | 24415402 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cells (CSCs) represent a subpopulation of cells responsible for tumor growth. | 24415402 |
| Secondary Neoplasm | Stem Cell Exhaustion | HNSCC stem cells mediate tumorigenesis and regional metastasis in vivo. | 24415402 |
| SERPINB3 wt Allele | Stem Cell Exhaustion | We hypothesized that the expression of two putative stem cell markers, ABCG2 and Bmi-1, would correlate with disease severity for non diseased, potentially malignant and OSCC specimens and cell lines derived from an equivalent range of tissues. | 24415717 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | [Treatment efficacy of imatinib mesylate versus allogeneic hematopoietic stem cell transplantation for patients with chronic myeloid leukemia in chronic phase]. | 24417923 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | To compare the treatment efficacy of imatinib mesylate versus allogeneic hematopoietic stem cell transplantation (allo-HSCT) for patients with chronic myeloid leukemia in chronic phase. | 24417923 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Impact of in vivo T-cell depletion on outcome of AML patients in first CR given peripheral blood stem cells and reduced-intensity conditioning allo-SCT from a HLA-identical sibling donor: a report from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation. | 24419525 |
| Arthralgia, Acute lymphocytic leukemia | Stem Cell Exhaustion | Case 2 describes a 48 year-old man with a history of acute lymphoblastic leukemia status post stem cell transplant who presented with diffuse arthralgias involving bilateral ankles, knees, wrists, and elbows. | 24421948 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Difference in mobilization of progenitor cells after myocardial infarction in smoking versus non-smoking patients: insights from the BONAMI trial. | 24423369 |
| Multiple Myeloma | Stem Cell Exhaustion | Inflammatory markers and development of symptom burden in patients with multiple myeloma during autologous stem cell transplantation. | 24423611 |
| Multiple Myeloma | Stem Cell Exhaustion | In this longitudinal study, we examined inflammatory factors related to the development of high symptom burden during autologous hematopoietic stem cell transplant (AuSCT) for multiple myeloma. | 24423611 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | Cytomegalovirus infected all cell types but showed higher tropism for stem cells/radial glial cells. | 24423639 |
| Congenital Abnormality, Destruction of tissue | Stem Cell Exhaustion | This suggests that the large spectrum of CMV-induced brain abnormalities is caused not only by tissue destruction but also by the particular vulnerability of stem cells during early brain development. | 24423639 |
| Prostatic epithelium, Carcinogenesis | Stem Cell Exhaustion | Bisphenol A promotes human prostate stem-progenitor cell self-renewal and increases in vivo carcinogenesis in human prostate epithelium. | 24424067 |
| Chronic active Epstein-Barr virus infection | Stem Cell Exhaustion | If it was the identical EBV clone, it is possible that EBV infected progenitor cells common to both NK cells and T cells, that the progenitor cells then differentiated into NK cells and T cells, a chronic active Epstein-Barr virus infection developed, and neoplastic transformation occurred. | 24427365 |
| Usual Severity Pain | Stem Cell Exhaustion | Patients with osteoarthritic changes who received mesenchymal stem cells experienced a significant reduction in pain compared with those who received the control, on the basis of visual analog scale assessments. | 24430407 |
| Usual Severity Pain | Stem Cell Exhaustion | There was evidence of meniscus regeneration and improvement in knee pain following treatment with allogeneic human mesenchymal stem cells. | 24430407 |
| Acute myocardial infarction | Stem Cell Exhaustion | A randomized, open-label, multicenter trial for the safety and efficacy of adult mesenchymal stem cells after acute myocardial infarction. | 24431901 |
| Acute myocardial infarction | Stem Cell Exhaustion | Recent studies suggest that the intracoronary administration of bone marrow (BM)-derived mesenchymal stem cells (MSCs) may improve left ventricular function in patients with acute myocardial infarction (AMI). | 24431901 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | We retrospectively examined the outcomes of 56 patients with diffuse large B-cell lymphoma (DLBCL) who underwent autologous stem cell transplant (ASCT) with BEAM/BEAC (carmustine, etoposide, cytarabine, melphalan/cyclophosphamide) or busulfan (Bu)-containing conditioning regimens. | 24432893 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | High dose chemotherapy with autologous stem cell transplant for patients with transformed B-cell non-Hodgkin lymphoma in the rituximab era. | 24432894 |
| Mantle cell lymphoma, Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Phase I/II study of bortezomib-BEAM and autologous hematopoietic stem cell transplantation for relapsed indolent non-Hodgkin lymphoma, transformed, or mantle cell lymphoma. | 24434781 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Autologous stem cell transplantation for follicular lymphoma is of most benefit early in the disease course and can result in durable remissions, irrespective of prior rituximab exposure. | 24438080 |
| Lymphoma, Follicular | Stem Cell Exhaustion | The role of autologous stem cell transplantation (ASCT) and the optimal timing of such transplants in patients with follicular lymphoma (FL) remains contentious. | 24438080 |
| varicella zoster | Stem Cell Exhaustion | Clinical features and risk factors for developing varicella zoster virus dissemination following hematopoietic stem cell transplantation. | 24438510 |
| varicella zoster, herpesvirus 3, human | Stem Cell Exhaustion | We retrospectively analyzed 80 instances of varicella zoster virus (VZV) disease in 72 patients who underwent allogeneic hematopoietic stem cell transplantation (HSCT) and examined the clinical differences between localized and disseminated disease. | 24438510 |
| Ischemia | Stem Cell Exhaustion | Phase I trial: the use of autologous cultured adipose-derived stroma/stem cells to treat patients with non-revascularizable critical limb ischemia. | 24438903 |
| Plasmacytoma - category | Stem Cell Exhaustion | Currently available treatment methods for advanced plasmacytoma include surgery, chemotherapy, radiotherapy, immunomodulatory agents, hematopoietic stem cell transplantation and donor lymphocyte infusion. | 24438905 |
| Stable chronic Graft vs Host Disease, Pancreatic Extracts, Chronic graft-versus-host disease | Stem Cell Exhaustion | To determine if patients with chronic graft-versus-host disease (cGVHD) following allogeneic hematopoietic stem cell transplantation (HSCT) develop greater loss of pancreatic tissue than patients without cGVHD. | 24441578 |
| Aplastic Anemia | Stem Cell Exhaustion | Evaluation of treatment responses and colony-forming progenitor cells in 50 patients with aplastic anemia after immunosuppressive therapy or hematopoietic stem cell transplantation: a single-center experience. | 24442858 |
| CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology | Stem Cell Exhaustion | Together, both IST and stem cell transplantation are reasonable treatment options for patients with AA. | 24442858 |
| Hemoglobinuria, CTCAE 3.0, CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology | Stem Cell Exhaustion | No obvious correlations between clinical parameters, including age, karyotype, existence of paroxysmal nocturnal hemoglobinuria clones, pretreatment blood counts, progenitor cell counts, and the response to immunosuppressive therapy (IST), were found. | 24442858 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Impaired osteogenic differentiation of mesenchymal stem cells derived from bone marrow of patients with lower-risk myelodysplastic syndromes. | 24443267 |
| Hepatotoxicity | Stem Cell Exhaustion | The current landscape of in vitro models used to identify drug- or chemical-induced hepatotoxicity relies heavily on cell culture models consisting of HepG2, induced pluripotent stem cell-derived, or primary hepatocytes. | 24444127 |
| Neurotoxicity Syndromes | Stem Cell Exhaustion | After 48 h exposure of H9 human neural stem cells to the neurotoxic fragment Ab25-35, mtDNA copy numbers were not significantly altered. | 24448779 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial. | 24449146 |
| Inflammation, Ischemia | Stem Cell Exhaustion | Vascular progenitor cells (VPCs) are recruited into the peripheral blood (PB) following ischemia and inflammation and correlate with vascular health. | 24449173 |
| Ischemic cardiomyopathy | Stem Cell Exhaustion | Transendocardial stem cell injection (TESI) with mesenchymal stem cells improves remodeling in chronic ischemic cardiomyopathy, but the effect of the injection site remains unknown. | 24449819 |
| Specialty Type - cancer | Stem Cell Exhaustion | Recently, studies indicated that cancer stem cell plays a key role in cancer development and progression. | 24450601 |
| Specialty Type - cancer, Squamous cell carcinoma, Trauma Symptom Checklist for Children Questionnaire | Stem Cell Exhaustion | However, the role of cancer stem cell has not been well elucidated in tongue squamous cell carcinoma (TSCC). | 24450601 |
| Trauma Symptom Checklist for Children Questionnaire | Stem Cell Exhaustion | The objective of this study was to investigate the relationships between the expressions of stem cell markers and the prognosis of TSCC. | 24450601 |
| Trauma Symptom Checklist for Children Questionnaire | Stem Cell Exhaustion | Taken together, these data suggest that the stem cell markers ALDH1, CD44, OCT4 and SOX2 are closely related in TSCC, and the expression of SOX2 can be used as a prognostic indicator of TSCC. | 24450601 |
| Brain Injuries | Stem Cell Exhaustion | As neurogenesis is an endogenous response to brain injury, visible as proliferation (of to this moment silent stem or progenitor cells), its further stimulation can present a treatment strategy in addition to stem cell transfer for cell regeneration therapy. | 24450810 |
| Kidney Diseases | Stem Cell Exhaustion | [Sodium-losing nephropathy caused by tacrolimus after allogeneic hematopoietic stem cell transplantation]. | 24452151 |
| Kidney Diseases | Stem Cell Exhaustion | Although sporadic kidney transplantation cases with sodium-losing nephropathy due to tacrolimus have been reported, no prior cases with this complication after hematopoietic stem cell transplantation (HSCT) have been reported. | 24452151 |
| Skin infiltration, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | [Inv(16)-type acute myeloid leukemia with repeated skin infiltration without bone marrow relapse before and after allogeneic hematopoietic stem cell transplantation]. | 24452154 |
| Tissue damage | Stem Cell Exhaustion | Bone marrow mesenchymal stromal cells to treat tissue damage in allogeneic stem cell transplant recipients: correlation of biological markers with clinical responses. | 24452962 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Bone marrow mesenchymal stromal cells (BMSCs) have been used to treat acute graft-versus-host disease (GVHD) and other complications following allogeneic hematopoietic stem cell transplantation (SCT). | 24452962 |
| Specialty Type - cancer | Stem Cell Exhaustion | A fourth clone, the less motile, displayed a cancer stem cell EpCAM+ phenotype, was essentially b-catenin negative, and was as expected devoid of hepatocytic differentiation capability, yet the most sensitive to doxorubicin treatment. | 24453043 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Hematopoietic stem cell transplantation for hematologic malignancies in older adults: geriatric principles in the transplant clinic. | 24453296 |
| methyldopa | Stem Cell Exhaustion | Here, we report the tumorigenic potential of induced pluripotent stem cell (iPSC)-derived retinal pigment epithelium (RPE) for the treatment of wet-type, age-related macular degeneration (AMD). | 24454843 |
| Immunocompromised Host, Mycoses | Stem Cell Exhaustion | Allogeneic granulocyte transfusion has evolved into a viable therapeutic option for immunocompromised severely neutropenic leukemic patients and those with hematopoietic stem cell transplant with life-threatening bacterial and fungal infections. | 24456072 |
| Hematologic Neoplasms, Tuberculosis | Stem Cell Exhaustion | T-SPOT.TB for detection of tuberculosis infection among hematological malignancy patients and hematopoietic stem cell transplant recipients. | 24460312 |
| Hematologic Neoplasms, Pregnancy Complications, Infectious | Stem Cell Exhaustion | The diagnosis of latent Mycobacterium tuberculosis infection (LTBI) is recommended in hematological malignancy patients and before hematopoietic stem cell transplantation (Guidelines for the prevention and management of infectious complications of solid organ transplantation, 2004). | 24460312 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Our study suggested that the T-SPOT.TB may be more useful for screening LTBI and active TB in hematological malignancy patients and hematopoietic stem cell transplant recipients than the TST test. | 24460312 |
| Neoplasms | Stem Cell Exhaustion | This study aimed to evaluate expression of aldehyde dehydrogenase 1 (ALDH1), a putative stem cell marker, in IBC tumors. | 24461456 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Tumors arising from cancer stem cells (CSCs) are associated with drug resistance, tumor recurrence, and poor prognosis. | 24461456 |
| Stable chronic Graft vs Host Disease | Stem Cell Exhaustion | To assess how BAFF levels relate to transplantation factors and subsequent development of cGVHD, we prospectively monitored 412 patients in the first year after allogeneic peripheral blood or bone marrow hematopoietic stem cell transplantation (HSCT) and censored data at time of cGVHD onset. | 24462743 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Antithymocyte globulin before allogeneic stem cell transplantation for progressive myelodysplastic syndrome: a study from the French Society of Bone Marrow Transplantation and Cellular Therapy. | 24462982 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | We investigated the impact of rabbit antithymocyte globulins (ATG) on patient outcomes after allogeneic stem cell transplantation (allo-SCT) for progressive myelodysplastic syndrome (MDS). | 24462982 |
| Virus Diseases | Stem Cell Exhaustion | BK virus disease after allogeneic stem cell transplantation: a cohort analysis. | 24462984 |
| FLT3 Internal Tandem Duplication, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Collectively, approximately 30 % of AML children were proved to carry favorable prognostic genetic abnormalities, whereas approximately 10 % had high FLT3-ITD allelic burden and needed a special treatment plan including allogeneic hematopoietic stem cell transplantation. | 24464319 |
| Adult Glioblastoma, Neoplasms | Stem Cell Exhaustion | GBMs are proposed to contain a subpopulation of glioblastoma stem cells (GSCs) that sustain tumor progression and therapeutic resistance and can form tumorspheres in culture. | 24464841 |
| Prolymphocytic Leukemia | Stem Cell Exhaustion | Successful allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning for B-cell prolymphocytic leukemia in partial remission. | 24470149 |
| Medulloblastoma | Stem Cell Exhaustion | High-dose busulfan-thiotepa with autologous stem cell transplantation followed by posterior fossa irradiation in young children with classical or incompletely resected medulloblastoma. | 24470384 |
| Medulloblastoma | Stem Cell Exhaustion | The aim of the study is to evaluate the outcome of young children with high risk localized medulloblastomas (newly diagnosed classical or incompletely resected) treated by high-dose busulfan-thiotepa with autologous stem cell rescue (ASCT) followed by focal radiation therapy (RT). | 24470384 |
| Aggressive course | Stem Cell Exhaustion | Unsustained complete response of less than 24 months after autologous stem cell transplantation predicts aggressive myeloma with short survival. | 24473998 |
| Multiple Myeloma | Stem Cell Exhaustion | To define the impact of duration of CR posttransplantation on survivals, 71 myeloma patients, who underwent an intended early (a staged approach) or frontline use of bortezomib-based induction, followed by autologous stem cell transplantation (ASCT) were studied. | 24473998 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | Absence of aberrant myeloid progenitor cells at baseline and/or a decrease in the FCSS during treatment identified Int-2 and high risk MDS patients who are likely to respond to treatment with azacitidine. | 24474614 |
| Progeria | Stem Cell Exhaustion | An upregulation in the expression of vanilloid transient potential channels 2 enhances hypotonicity-induced cytosolic Ca2+ rise in human induced pluripotent stem cell model of Hutchinson-Gillford Progeria. | 24475260 |
| LMNA wt Allele | Stem Cell Exhaustion | The aim of this present study was to examine the expression and functional role of TRP channels in human induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) from the patients with HGPS. | 24475260 |
| Episode of | Stem Cell Exhaustion | Hematopoietic stem cell transplantation could not be done and the evolution was fatal in both cases because of severe infectious episodes. | 24476615 |
| Hip Joint | Stem Cell Exhaustion | The overarching aim of this study is to assess the feasibility of using periosteal tissue from the femoral neck of arthritic hip joints, usually discarded in the normal course of hip replacement surgery, as an autologous source of stem cells. | 24477075 |
| Rheumatoid Arthritis, Degenerative polyarthritis | Stem Cell Exhaustion | In sum, periosteum tissue that is resected with the femoral neck in replacing the hip represents an unprecedented and, to date, unstudied source of stem cells from OA and RA patients. | 24477075 |
| Chylothorax | Stem Cell Exhaustion | Eventually, her chylothorax was controlled by pleurodesis, and she was transferred to another hospital for stem cell transplantation. | 24477187 |
| Drug Hypersensitivity Syndrome, United States Indian Health Service | Stem Cell Exhaustion | PCR products of various sizes were amplified in four clinical isolates from drug-induced hypersensitivity syndrome (DIHS) patients and 15 isolates from hematopoietic stem cell transplant (HSCT) recipients with HHV-6B reactivation. | 24478470 |
| Candidiasis | Stem Cell Exhaustion | Micafungin has been approved for the prophylaxis of Candida infections in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 24479680 |
| Cerebrovascular accident | Stem Cell Exhaustion | Intracerebral implantation of autologous peripheral blood stem cells in stroke patients: a randomized phase II study. | 24480430 |
| Cerebral Infarction | Stem Cell Exhaustion | In our previous study, intracerebral implantation of peripheral blood stem cells (PBSCs) improved functional outcome in rats with chronic cerebral infarction. | 24480430 |
| Specialty Type - cancer | Stem Cell Exhaustion | Nestin, a class VI intermediate filament, is known to be a cancer stem cell (CSC) marker as well as a neuroepithelial stem cell marker. | 24481417 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | Roles of Wnt/b-catenin signaling in the gastric cancer stem cells proliferation and salinomycin treatment. | 24481453 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | The Wnt1 protein, a secreted ligand that activates Wnt signaling pathways, contributes to the self-renewal of cancer stem cells (CSCs) and thus may be a major determinant of tumor progression and chemoresistance. | 24481453 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | A standardized panel of reagents was used to detect residual disease of aberrant myeloid progenitor cells (RD), identify neutrophils/monocytes with dysregulated immunophenotype (dysregulated neutro/mono) and quantify the appearance of CD34(+) B-progenitor-related cluster (hematogones) simultaneously in post-induction BM of adult AML patients. | 24481944 |
| Specialty Type - cancer | Stem Cell Exhaustion | Embryonic stem cells (ESC) and cancer stem cells (CSC) have a capacity for self-renewal and differentiation into multiple cell lineages. | 24482053 |
| Seckel syndrome | Stem Cell Exhaustion | Successful outcome of allogeneic stem cell transplantation in Seckel syndrome. | 24483323 |
| Compression of umbilical cord, Pfaundler-Hurler Syndrome | Stem Cell Exhaustion | Hematopoietic stem cell transplantation effects on spinal cord compression in Hurler. | 24483599 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | Reprogramming of COPD lung fibroblasts through formation of induced pluripotent stem cells. | 24487392 |
| Hemorrhagic cystitis | Stem Cell Exhaustion | High burden of BK virus-associated hemorrhagic cystitis in patients undergoing allogeneic hematopoietic stem cell transplantation. | 24488049 |
| Specialty Type - cancer | Stem Cell Exhaustion | Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/b-catenin signaling. | 24491301 |
| Colorectal Carcinoma, Specialty Type - cancer, Cytogenetic Complete Response | Stem Cell Exhaustion | However, little is known about the role these mutations play in cancer stem cells (CSCs) associated with colorectal cancer (CRC) tumorigenesis. | 24491301 |
| B-Cell Lymphomas | Stem Cell Exhaustion | High-dose chemotherapy with autologous stem cell transplantation for elderly patients with relapsed/refractory diffuse large B cell lymphoma: a nationwide retrospective study. | 24492141 |
| B-Cell Lymphomas, Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | The number of elderly patients with diffuse large B cell lymphoma (DLBCL) continues to increase but the data regarding autologous stem cell transplantation (ASCT) for elderly patients are limited. | 24492141 |
| Endotoxemia | Stem Cell Exhaustion | Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model. | 24496748 |
| Diabetes | Stem Cell Exhaustion | This implies that diabetes may lead to reduced endogenous repair mechanisms through altering the differentiation potential of MPCs and, consequently, disrupting the stem cell niche. | 24496952 |
| Diabetes, Osteopenia | Stem Cell Exhaustion | This novel mechanism may account for increased bone marrow adipogenesis, severe bone loss, and reduced vascular stem cells leading to chronic secondary complications of diabetes. | 24496952 |
| leukemia | Stem Cell Exhaustion | Finally, we hypothesized that CXCR7 potentiates CXCR4 response and may contribute to the maintenance of leukemia by initiating cell recruitment to bone marrow niches that were once occupied by normal hematopoietic stem cells. | 24497931 |
| Hyperglycemia, Specimen Type - Menstrual blood, diabetic | Stem Cell Exhaustion | Transplantation of human menstrual blood progenitor cells improves hyperglycemia by promoting endogenous progenitor differentiation in type 1 diabetic mice. | 24499421 |
| Specimen Type - Menstrual blood | Stem Cell Exhaustion | Recently, a unique population of progenitor cells was isolated from human menstrual blood. | 24499421 |
| Granuloma | Stem Cell Exhaustion | On 55 meshes explanted from humans, we characterised the cells in the inflammatory infiltrate of the granuloma by immunohistochemistry using 10 cellular markers: CD3+ lymphocytes, CD4+ T helper cells, CD8+ cytotoxic T cells, CD20+ B lymphocytes, CD34+ stem cells, CD45R0+ leucocytes, CD68+ macrophages, Mib1 for proliferation, Vimentin for mesenchymal origin, and Desmin for myocytes. | 24500375 |
| Non-Small Cell Lung Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Activated leukocyte cell adhesion molecule (CD166): an "inert" cancer stem cell marker for non-small cell lung cancer? | 24501004 |
| Non-Small Cell Lung Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Recently, the activated leukocyte cell adhesion molecule (CD166) was identified as an "inert" cancer stem cell (CSC) marker for non-small cell lung cancer (NSCLC). | 24501004 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Primary distal femur T-cell lymphoma after allogeneic haematopoietic stem cell transplantation for chronic myeloid leukaemia: a rare case report and literature review. | 24501166 |
| Post-transplant lymphoproliferative disorder | Stem Cell Exhaustion | Post-transplant lymphoproliferative disorders originating from T lymphocytes are a rare complication of allogeneic haematopoietic stem cell transplantation (allo-HSCT) that are not usually associated with Epstein-Barr virus infection. | 24501166 |
| Amyloidosis | Stem Cell Exhaustion | Outcomes and treatments of patients with immunoglobulin light chain amyloidosis who progress or relapse postautologous stem cell transplant. | 24502602 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Lenalidomide-induced graft-vs.-Leukemia effect in a patient with chronic lymphocytic leukemia who relapsed after allogeneic stem cell transplant. | 24502832 |
| Specialty Type - cancer | Stem Cell Exhaustion | Expression of the cancer stem cell markers CD44v6 and ABCG2 in tongue cancer: effect of neoadjuvant chemotherapy on local recurrence. | 24504189 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | The purpose of this study was to evaluate the effect of NAC on tumor local recurrence using cancer stem cell marker immunohistochemistry. | 24504189 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cell marker (CD44v6 and ABCG2) expression was detected by immunohistochemistry. | 24504189 |
| Specialty Type - cancer | Stem Cell Exhaustion | A low expression of miR-200a was also observed in cancer stem cell-enriched spheroid growth conditions (P<0.05). | 24504363 |
| Specialty Type - cancer, Cytogenetic Complete Response, MIR200A gene | Stem Cell Exhaustion | MiR-200a has a regulatory effect on EMT and is associated with cancer stem cell properties in CRC. | 24504363 |
| Failure (biologic function) | Stem Cell Exhaustion | We made the hypothesis that it would be possible to load these grafts with bone marrow derived mesenchymal stem cells (MSC) to rescue the osteogenic capacity of an allogenic dead bone and therefore enhance incorporation of allografts with the host bone and decrease the number of failures related to the allograft. | 24509980 |
| Failure | Stem Cell Exhaustion | The rate of mechanical failure was highest (p = 0.01) among the 30 patients with allograft without stem cells (9/30; 30 %) compared with no failures for patients with allograft loaded with stem cells. | 24509980 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | In cancer cells, the process of epithelial-mesenchymal transition (EMT) confers migratory and invasive capacity, resistance to apoptosis, drug resistance, evasion of host immune surveillance and tumor stem cell traits. | 24510113 |
| Amyotrophic Lateral Sclerosis | Stem Cell Exhaustion | Intraspinal neural stem cell transplantation in amyotrophic lateral sclerosis: phase 1 trial outcomes. | 24510776 |
| Amyotrophic Lateral Sclerosis, Antilymphocyte Serum | Stem Cell Exhaustion | Our overall objective was to assess the safety and feasibility of stem cell transplantation into lumbar and/or cervical spinal cord regions in amyotrophic lateral sclerosis (ALS) subjects. | 24510776 |
| Antilymphocyte Serum | Stem Cell Exhaustion | Here, we describe the safety and functional outcome monitoring results for the final trial cohort, consisting of 6 ALS subjects receiving 5 unilateral cervical intraspinal neural stem cell injections. | 24510776 |
| Antilymphocyte Serum | Stem Cell Exhaustion | Analyses on outcome data revealed preliminary insight into potential windows of stem cell biological activity and identified clinical assessment measures that closely correlate with ALS Functional Rating Scale-Revised scores, a standard assessment for ALS clinical trials. | 24510776 |
| Antilymphocyte Serum | Stem Cell Exhaustion | This is the first report of cervical and dual-targeted intraspinal transplantation of neural stem cells in ALS subjects. | 24510776 |
| Specialty Type - cancer | Stem Cell Exhaustion | Aldehyde dehydrogenase-1 (ALDH1) has been considered as a potential cancer stem cell marker in different types of cancer. | 24511023 |
| Squamous cell carcinoma of vulva, Specialty Type - cancer | Stem Cell Exhaustion | Contrary to the characteristics of cancer stem cells shown in other types of cancer with positive expression of ALDH1, the positive expression of ALDH1 in patients with vulvar squamous cell carcinoma indicates a significantly better prognosis. | 24511023 |
| Electrocardiogram: myocardial infarction (finding), Ventricular Dysfunction | Stem Cell Exhaustion | Results from pre-clinical studies and the CADUCEUS (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction) trial support the notion that cardiosphere-derived cells (CDCs) from normal and recently infarcted hearts are capable of regenerating healthy heart tissue after myocardial infarction (MI). | 24511463 |
| Hematologic Neoplasms, Childhood Breast Carcinoma | Stem Cell Exhaustion | Ferritin has been shown to be prognostically relevant in breast cancer and in patients with hematologic malignancies undergoing autologous or allogeneic stem cell transplantation. | 24512320 |
| Multiple Myeloma | Stem Cell Exhaustion | In the present study, we evaluated the prognostic relevance of pretransplant ferritin levels in 137 patients with myeloma (median age: 56 years) subjected to autologous stem cell transplantation in our institution between 1994 and 2010. | 24512320 |
| Malignant neoplasm of breast, Specialty Type - cancer | Stem Cell Exhaustion | If we take translocation frequency as a surrogate marker of potential carcinogenic effect of radiation, the current results suggest that fetal irradiation can induce persistent potential carcinogenic damage in mammary stem/progenitor cells but this does not contribute to the increased risk of cancer since it has been reported that irradiation of fetal rats of the SD strain does not increase the risk of mammary cancers. | 24512615 |
| Hypersensitivity | Stem Cell Exhaustion | Moreover, ectopic expression of HACE1 in striatal neuronal progenitor cells provided protection against mutant Huntingtin-induced redox imbalance and hypersensitivity to oxidative stress, by augmenting NRF2 functions. | 24516159 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | In acute myeloid leukemia (AML), the leukemia initiating cells (LICs) or leukemia stem cells (LSCs) is found within the CD34+CD38- cell compartment. | 24517186 |
| Specialty Type - cancer | Stem Cell Exhaustion | The Wnt signaling pathway is a developmental and stem cell pathway that plays an important role in tumorigenesis and may affect cancer progression. | 24517998 |
| Childhood Breast Carcinoma, Secondary Neoplasm | Stem Cell Exhaustion | Breast cancer stem cells are thought to be associated with metastasis and poor prognosis, but their clinical importance remains poorly understood. | 24519209 |
| Childhood Breast Carcinoma, Secondary Neoplasm | Stem Cell Exhaustion | The aim of this study was to investigate whether certain phenotypes of breast cancer stem cells were clinically important factors regarding metastasis. | 24519209 |
| Childhood Breast Carcinoma, Neoplasms | Stem Cell Exhaustion | Breast cancer stem cells were identified by immunohistochemical staining of CD44, CD24, and aldehyde dehydrogenase 1 (ALDH1) in tumor tissues from primary and recurrent or metastatic lesions. | 24519209 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | CD44+/CD24- cells and ALDH1+ cells were considered breast cancer stem cells. | 24519209 |
| Childhood Breast Carcinoma, Secondary Neoplasm | Stem Cell Exhaustion | Our findings suggest that ALDH1+ and CD44+/CD24- breast cancer stem cells play significant roles in metastasis. | 24519209 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | Efficacy of cryotherapy associated with laser therapy for decreasing severity of melphalan-induced oral mucositis during hematological stem-cell transplantation: a prospective clinical study. | 24519448 |
| Hematopoietic Neoplasms, Multiple Myeloma | Stem Cell Exhaustion | Melphalan followed by hematopoietic stem-cell transplantation (HSCT) is the standard treatment for multiple myeloma and other hematopoietic neoplasms. | 24519448 |
| Mixed Oligodendroglioma-Astrocytoma, Astrocytoma | Stem Cell Exhaustion | High expression of the stem cell marker nestin is an adverse prognostic factor in WHO grade II-III astrocytomas and oligoastrocytomas. | 24519516 |
| Neoplasms | Stem Cell Exhaustion | Pubertal bisphenol A exposure alters murine mammary stem cell function leading to early neoplasia in regenerated glands. | 24520039 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | It also reduces the number of radio-resistant CD133(+) glioma stem cells. | 24521695 |
| Neoplasms | Stem Cell Exhaustion | Finally, using a stem cell proliferation assay and tumour xenotransplantation assay in non-obese diabetic/severe combined immunodeficiency mice, we show that HAGE promotes MMICs-dependent tumour initiation and tumour growth by preventing the anti-proliferative effects of interferon-a (IFNa). | 24525737 |
| melanoma, Specialty Type - cancer | Stem Cell Exhaustion | Here, we show the involvement of the helicase HAGE in the transcriptional repression of PML expression in ABCB5+ malignant melanoma-initiating cells (ABCB5+ MMICs), a population of cancer stem cells which are responsible for melanoma growth, progression and resistance to drug-based therapy. | 24525737 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | cIAP1, SMAC, and caspase-8 appear to play a role in AML stem cell survival, and synergistic targeting of these cells with birinapant and demethylating agents shows potential utility in leukemia therapy. | 24526787 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Synergistic targeting of AML stem/progenitor cells with IAP antagonist birinapant and demethylating agents. | 24526787 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Acute myeloid leukemia (AML) therapy has limited long-term efficacy because patients frequently develop disease relapse because of the inability of standard chemotherapeutic agents to target AML stem/progenitor cells. | 24526787 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Here, we identify deregulated apoptotic components in AML stem/progenitor cells and investigate the individual and combinatorial effects of the novel inhibitor of apoptosis (IAP) protein antagonist and second mitochondrial-derived activator of caspases (SMAC) mimetic birinapant and demethylating epigenetic modulators. | 24526787 |
| Cessation of life, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Birinapant induced death receptor-/caspase-8-mediated apoptosis in AML cells, including in AML stem/progenitor cells, but not in normal CD34(+) cells. | 24526787 |
| Graft-vs-Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | In unrelated donor allogeneic stem cell transplantation (URD-SCT), most studies reported that peripheral blood stem cells (PBSC) resulted in higher incidence of acute and/or chronic graft-versus-host disease (GVHD) without survival benefits compared with bone marrow (BM). | 24527665 |
| Graft-vs-Host Disease, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Similar outcomes of peripheral blood stem cells vs. bone marrow for human leukocyte antigen-matched unrelated donor transplantation in adult patients with acute myeloid leukemia using risk-adapted graft-versus-host disease prophylaxis. | 24527665 |
| Specialty Type - cancer, Squamous cell carcinoma of the head and neck | Stem Cell Exhaustion | Spatial distribution of cancer stem cells in head and neck squamous cell carcinomas. | 24527751 |
| Specialty Type - cancer | Stem Cell Exhaustion | miR-296-5p is a central regulator of signalling pathways affecting development, stem cell differentiation and cancer. | 24527800 |
| Childhood Breast Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | We hypothesized that miR-296-5p is involved in breast cancer onset and progression possibly through regulation of its target SCRIB (Scribble), a polarity protein recently implicated in the acquisition of cancer stem cell traits and in cell motility. | 24527800 |
| Malignant Neoplasms | Stem Cell Exhaustion | A prospective study of an alemtuzumab containing reduced-intensity allogeneic stem cell transplant program in patients with poor-risk and advanced lymphoid malignancies. | 24528216 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Reduced-intensity conditioning (RIC) regimens for allogeneic stem cell transplant (allo-SCT) have used alemtuzumab to abrogate the risk of graft-versus-host disease (GVHD). | 24528216 |
| Non-alcoholic Fatty Liver Disease | Stem Cell Exhaustion | The non-alcoholic fraction of beer increases stromal cell derived factor 1 and the number of circulating endothelial progenitor cells in high cardiovascular risk subjects: a randomized clinical trial. | 24530788 |
| Fracture | Stem Cell Exhaustion | While PTH 1-34 enhances the proliferation and expansion of the periosteal stem cell population and accelerates bone formation and fracture healing, the effects are proportionately reduced in aged mice compared to young mice. | 24530870 |
| Fracture | Stem Cell Exhaustion | Altogether the findings show that reduced fracture healing in aging involves decreased proliferation and differentiation of stem cells lining the bone surface. | 24530870 |
| Bone injury | Stem Cell Exhaustion | Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment. | 24530870 |
| Primary Cutaneous B-Cell Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Myeloablative therapy and autologous stem cell transplantation (ASCT) are underutilized in older patients with B cell non-Hodgkin (B-NHL) lymphoma. | 24530971 |
| Specialty Type - cancer, Triple Negative Breast Neoplasms | Stem Cell Exhaustion | The TrkB+ cancer stem cells contribute to post-chemotherapy recurrence of triple-negative breast cancers in an orthotopic mouse model. | 24531713 |
| Specialty Type - cancer, Triple-Negative Breast Cancer Finding | Stem Cell Exhaustion | Cancer stem cells (CSCs) are believed to have a crucial role in triple-negative breast cancer (TNBC) recurrence. | 24531713 |
| Multiple Myeloma | Stem Cell Exhaustion | Subcutaneous bortezomib incorporated into the bortezomib-thalidomide-dexamethasone regimen as part of front-line therapy in the context of autologous stem cell transplantation for multiple myeloma. | 24532044 |
| Malignant tumor of cervix | Stem Cell Exhaustion | Clinical significance of the stem cell gene Oct-4 in cervical cancer. | 24532469 |
| Malignant tumor of cervix, Psychobiology | Stem Cell Exhaustion | Our results showed that Oct-4 was highly expressed in cervical cancer stem cells; Oct-4 expression was associated with biological behavior and was an independent prognostic factor in cervical cancer. | 24532469 |
| Stable chronic Graft vs Host Disease | Stem Cell Exhaustion | To address this in cGVHD, we studied B-cell receptor (BCR) responsiveness in 48 patients who were >1 year out from allogeneic hematopoietic stem cell transplantation (HSCT). | 24532806 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Pretransplantation fluorine-18-deoxyglucose--positron emission tomography scan lacks prognostic value in chemosensitive B cell non-hodgkin lymphoma patients undergoing nonmyeloablative allogeneic stem cell transplantation. | 24534109 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | The effect of peritransplant minimal residual disease in adults with acute lymphoblastic leukemia undergoing allogeneic hematopoietic stem cell transplantation. | 24548609 |
| Multiple Endocrine Neoplasia Type 1 | Stem Cell Exhaustion | Induced pluripotent stem cells as a model for telomeric abnormalities in ICF type I syndrome. | 24549038 |
| Hematopoietic stem cells, Lymphoid neoplasm, Myeloid | Stem Cell Exhaustion | Myeloid and lymphoid neoplasms with abnormalities of the FGFR1 gene are a heterogenous group of rare and aggressive hematopoietic stem cell disorders. | 24551307 |
| Neoplasm Metastasis | Stem Cell Exhaustion | Secondary malignancies after allogeneic hematopoietic stem cell transplantation using reduced-intensity conditioning and outpatient conduction. | 24552480 |
| Malignant Neoplasms | Stem Cell Exhaustion | Patients given allogeneic hematopoietic stem cell transplants (HSCT) may develop secondary malignant neoplasms (SMN). | 24552480 |
| Specialty Type - cancer | Stem Cell Exhaustion | Intriguingly, acquired resistance to metformin appears to trigger a transcriptome reprogramming toward a metastatic stem-like profile, as many genes encoding the components of the degradome (KLK11, CTSF, FREM1, BACE-2, CASP, TMPRSS4, MMP16, HTRA1), cancer cell migration and invasion factors (TP63, WISP2, GAS3, DKK1, BCAR3, PABPC1, MUC1, SPARCL1, SEMA3B, SEMA6A), stem cell markers (DCLK1, FAK), and key pro-metastatic lipases (MAGL and Cpla2) were included in the signature. | 24553122 |
| Acute leukemia | Stem Cell Exhaustion | Prognostic index for relapsed acute leukemia after allogeneic stem cell transplant. | 24555841 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Narrowband ultraviolet B phototherapy (NB-UVB) is a therapeutic alternative for haematopoietic stem cell transplantation-related skin graft-versus-host disease (GVHD). | 24557710 |
| Hematologic Neoplasms, Diabetes Mellitus | Stem Cell Exhaustion | Risk factors for diabetes mellitus and impaired glucose tolerance following allogeneic hematopoietic stem cell transplantation in pediatric patients with hematological malignancies. | 24557711 |
| Dominica, Diabetes Mellitus | Stem Cell Exhaustion | Long-term surviving recipients of allogeneic hematopoietic stem cell transplantation (HSCT) often suffer from diabetes mellitus (DM). | 24557711 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Approximately one-third of patients with myelodysplastic syndrome (MDS) receiving allogeneic hematopoietic stem cell transplantation (HSCT) are cured by this treatment. | 24558201 |
| Lymphoma, Follicular, Respiratory Tract Infections | Stem Cell Exhaustion | A 50 year old Caucasian gentleman with a history of allogeneic haematopoietic stem cell transplant for transformed follicular lymphoma was admitted to hospital with recurrent respiratory tract infections. | 24559411 |
| Acute myelomonocytic leukemia | Stem Cell Exhaustion | Cochlear implantation in a patient with acute myelomonocytic leukemia before allogeneic peripheral blood stem cell transplantation. | 24560096 |
| leukemia | Stem Cell Exhaustion | A 50-year-old female leukemia patient was successfully implanted with a Nucleus cochlear implant while in complete remission before peripheral blood stem cell transplantation. | 24560096 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Autologous stem cell transplantation in mantle cell lymphoma: a report from the SFGM-TC. | 24563925 |
| Medial collateral ligament, Mantle cell lymphoma | Stem Cell Exhaustion | Autologous stem cell transplantation (ASCT) is considered as an attractive treatment option for young mantle cell lymphoma (MCL) patients. | 24563925 |
| Kidney Failure, Acute | Stem Cell Exhaustion | Clofarabine-associated acute kidney injury in patients undergoing hematopoietic stem cell transplant. | 24564572 |
| Toxic nephropathy | Stem Cell Exhaustion | Abstract We examined clofarabine pharmacokinetics and association with renal toxicity in 62 patients participating in a phase I-II study of clofarabine-melphalan-alemtuzumab conditioning for hematopoietic stem cell transplant (HSCT). | 24564572 |
| Leukemia, T-Cell | Stem Cell Exhaustion | High level of serum soluble interleukin-2 receptor at transplantation predicts poor outcome of allogeneic stem cell transplantation for adult T cell leukemia. | 24565990 |
| TCL4 gene, TRPV6 wt Allele | Stem Cell Exhaustion | The prognosis for adult T cell leukemia/lymphoma (ATL) is very poor, and only allogeneic hematopoietic stem cell transplantation (allo-SCT) has been considered to be a curative treatment for ATL. | 24565990 |
| diabetic | Stem Cell Exhaustion | Effect of diabetic osteoblasts on osteogenic differentiation of human umbilical cord mesenchymal stem cells. | 24566377 |
| diabetic | Stem Cell Exhaustion | This study was aimed to investigate whether osteoblasts from diabetic patients have a promoting effect on osteogenesis of human umbilical cord mesenchymal stem cells (HUMSCs). | 24566377 |
| Thrombotic Microangiopathies | Stem Cell Exhaustion | Risk factors for thrombotic microangiopathy in allogeneic hematopoietic stem cell recipients receiving GVHD prophylaxis with tacrolimus plus MTX or sirolimus. | 24566710 |
| Multiple Myeloma | Stem Cell Exhaustion | This paper is motivated by the analysis of a longitudinal study on advanced myeloma patients who received stem cell transplants and T cell infusions after the transplants. | 24567438 |
| Carcinoma, Transitional Cell | Stem Cell Exhaustion | Stem cell marker-positive stellate cells and mast cells are reduced in benign-appearing bladder tissue in patients with urothelial carcinoma. | 24570393 |
| Malignant neoplasm of urinary bladder, Bladder Neoplasm | Stem Cell Exhaustion | Our aim was therefore to determine identities of stem cell marker-positive cells in bladder cancer tissue and to investigate possible associations between these cells and different forms of bladder neoplasia. | 24570393 |
| Neoplasms | Stem Cell Exhaustion | Stem cell marker-positive cells exhibiting possible stem cell characteristics included cells in deeper locations of benign and malignant epithelium, and sub-endothelial cells in patients with or without neoplasia. | 24570393 |
| Disease, Malignant Neoplasms, Immunoglobulin deficiency, Congenital absence of spleen, HIV Infections | Stem Cell Exhaustion | ACIP also recommends vaccination for certain persons at increased risk for Hib disease (i.e., persons who have early component complement deficiencies, immunoglobulin deficiency, anatomic or functional asplenia, or HIV infection; recipients of hematopoietic stem cell transplant; and recipients of chemotherapy or radiation therapy for malignant neoplasms). | 24572654 |
| Acute myocardial infarction | Stem Cell Exhaustion | An increase of endothelial progenitor cells (EPCs) among acute myocardial infarction (AMI) patients participating in a cardiac rehabilitation (CR) program has been reported, but no data on the impact of adherence to lifestyle recommendations provided during a CR program on EPCs are available. | 24573342 |
| Degenerative disorder, methyldopa | Stem Cell Exhaustion | A recent example is the development of stem cell-based therapies for degenerative eye diseases including AMD. | 24573369 |
| Degenerative disorder | Stem Cell Exhaustion | The utility of this behavior was described in terms of how it could allow us to remove road blocks in the clinical development pipeline, and more efficiently and economically move stem cell-based therapies for retinal degenerative diseases toward the clinic. | 24573369 |
| Hepatitis B | Stem Cell Exhaustion | Hepatitis B reactivation in HBsAg-negative/HBcAb-positive allogeneic haematopoietic stem cell transplant recipients: risk factors and outcome. | 24575948 |
| Hepatitis B | Stem Cell Exhaustion | HBsAg-negative/HBcAb-positive haematopoietic stem cell transplant (HSCT) recipients are at high risk of hepatitis B virus (HBV) reactivation. | 24575948 |
| Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Pulmonary chronic graft-versus-host disease (cGvHD) is one of the most common causes of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (aHSCT). | 24577553 |
| Chronic Obstructive Airway Disease, Pulmonary arterial hypertension | Stem Cell Exhaustion | Influence of Rho kinase inhibitor Fasudil on late endothelial progenitor cells in peripheral blood of COPD patients with pulmonary artery hypertension. | 24579970 |
| Chronic Obstructive Airway Disease, Lung Diseases, Obstructive, Pulmonary arterial hypertension | Stem Cell Exhaustion | The objective of our work was to investigate the influence of Fasudil, a Rho inhibitor on the number and function of the late endothelial progenitor cells in peripheral blood of chronic obstructive pulmonary diseases (COPD) patients with pulmonary artery hypertension. | 24579970 |
| Chronic Obstructive Airway Disease, Pulmonary arterial hypertension | Stem Cell Exhaustion | The Rho-kinase inhibitor Fasudil increased the number and enhanced the function of the late endothelial progenitor cells in peripheral blood of COPD patients with pulmonary artery hypertension. | 24579970 |
| Glycogen Storage Disease | Stem Cell Exhaustion | Establishment and directed differentiation of induced pluripotent stem cells from glycogen storage disease type Ib patient. | 24581426 |
| Disease | Stem Cell Exhaustion | Induced pluripotent stem cells (iPSCs) hold a great promise for advances in developmental biology, cell-based therapy and modeling of human disease. | 24581426 |
| Prostate carcinoma | Stem Cell Exhaustion | An expressed retrogene of the master embryonic stem cell gene POU5F1 is associated with prostate cancer susceptibility. | 24581739 |
| Specialty Type - cancer | Stem Cell Exhaustion | Our results suggest that a pathway critical to self-renewal of embryonic stem cells may also have a role in the origin of cancer. | 24581739 |
| Multiple Myeloma | Stem Cell Exhaustion | Characteristics of unexpected protein bands in multiple myeloma patients after autologous stem cell transplantation. | 24582697 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Immunologic disparities between minor histocompatibility antigen (mHAg) genes on Y (H-Y) and X (H-X) chromosomes contribute to graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) effects observed in male recipients of a female donor (FtoM) hematopoietic stem cell transplant (HCT). | 24582729 |
| B-Cell Lymphomas | Stem Cell Exhaustion | Impact of cytomegalovirus replication and cytomegalovirus serostatus on the outcome of patients with B cell lymphoma after allogeneic stem cell transplantation. | 24583412 |
| Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | Stem Cell Exhaustion | Outcome and prognostic factors in patients with mantle-cell lymphoma relapsing after autologous stem-cell transplantation: a retrospective study of the European Group for Blood and Marrow Transplantation (EBMT). | 24585719 |
| Medial collateral ligament, Mantle cell lymphoma | Stem Cell Exhaustion | Autologous stem-cell transplantation (autoSCT) is considered a standard treatment of non-frail patients with mantle cell lymphoma (MCL), but little is known about outcome of MCL patients relapsing after autoSCT. | 24585719 |
| Malignant tumor of colon | Stem Cell Exhaustion | Prognostic value of stem cell quantification in stage II colon cancer. | 24586330 |
| Stage II Colon Cancer AJCC v8 | Stem Cell Exhaustion | Stem Cell quantification defined by CD133 and NANOG expression has no correlation with RFS or OS in this cohort of Stage II colon cancer. | 24586330 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cells (CSCs) are a subset of tumor cells with capacity to self-renew and generate the diverse cells that make up the tumor. | 24586330 |
| bone marrow fibrosis, Primary Myelofibrosis | Stem Cell Exhaustion | Dynamic of bone marrow fibrosis regression predicts survival after allogeneic stem cell transplantation for myelofibrosis. | 24589549 |
| bone marrow fibrosis, Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase | Stem Cell Exhaustion | We correlate regression of bone marrow fibrosis (BMF) on day 30 and 100 after dose- reduced allogeneic stem cell transplantation (allo-SCT) in 57 patients with primary or post-essential thrombocythemia/polycythemia vera myelofibrosis with graft function and survival. | 24589549 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Although calcineurin inhibitors (CNIs) with short-term methotrexate (stMTX) constitute standard prophylaxis for graft-versus-host diseases (GVHD) in hematopoietic stem cell transplantations (HSCT), comparative efficacy of cyclosporine A (CsA) and tacrolimus (Tac) still remains unclear. | 24590535 |
| GTF2A1L wt Allele, altretamine/cisplatin/cyclophosphamide protocol | Stem Cell Exhaustion | Histological examination and immunohistochemical analysis of proliferating hepatocytes and activated hepatic progenitor cells (HPCs) were performed on the liver tissue of patients with ALF (25), ACLF (70), and CHD (70). | 24590583 |
| Specialty Type - cancer | Stem Cell Exhaustion | Circulating hematopoietic stem and progenitor cells are myeloid-biased in cancer patients. | 24591638 |
| Neoplasms | Stem Cell Exhaustion | Subpopulations of HNSCC display stem cell features that affect patients' tumor control and survival. | 24593279 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Experimental and clinical data suggest that solid cancers contain treatment-resistant cancer stem cells that will impair treatment efficacy. | 24593279 |
| Specialty Type - cancer, Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Stem Cell Exhaustion | The objective of this study was to investigate if head and neck squamous cell carcinoma (HNSCC) also contain cancer stem cells that can be identified by low 26S proteasome activity and if their presence correlates to clinical outcome. | 24593279 |
| Congestive heart failure | Stem Cell Exhaustion | Despite a high potential of endothelial progenitor cells (EPCs) for diagnostic purposes, the EPC role in developing ischemic chronic heart failure (CHF) has not been determined obviously. | 24594088 |
| Neoplasms | Stem Cell Exhaustion | Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5), which is identified as a novel intestinal stem cell marker, is overexpressed in various tumours. | 24594994 |
| Specialty Type - cancer | Stem Cell Exhaustion | We performed a retrospective analysis of patients with TrIL treated at Peter MacCallum Cancer Centre between 2002 and 2012 who achieved CMR after primary therapy who had >=1 subsequent surveillance PET-CT. Of 55 patients with TrIL, 37 (67 %) received autologous stem cell transplantation as consolidation following chemoimmunotherapy. | 24595733 |
| Relapsing course | Stem Cell Exhaustion | [Relapsed primary intraocular lymphoma treated with intravitreal methotrexate and high-dose chemotherapy followed by autologous stem cell rescue]. | 24598193 |
| Progeria | Stem Cell Exhaustion | Induced pluripotent stem cells reveal functional differences between drugs currently investigated in patients with hutchinson-gilford progeria syndrome. | 24598781 |
| Progeria | Stem Cell Exhaustion | This work was based on the assumption that mesodermal stem cells, which are derived from Hutchinson-Gilford progeria syndrome-induced pluripotent stem cells expressing major defects associated with the disease, may be instrumental to revealing such effects. | 24598781 |
| Cerebral Infarction | Stem Cell Exhaustion | Mobilization of CD133+ progenitor cells in patients with acute cerebral infarction. | 24599235 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Soluble interleukin-2 receptor level on day 7 as a predictor of graft-versus-host disease after HLA-haploidentical stem cell transplantation using reduced-intensity conditioning. | 24599414 |
| Acute GVH disease | Stem Cell Exhaustion | Treatment difficulty with acute GVHD - frequent cause of mortality after allogeneic hematopoietic stem cell transplantation. | 24601700 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Acute graft-versus-host disease (aGvHD) remains a significant cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). | 24601700 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | We proved a higher incidence of developing aGvHD in patients with unrelated donor type, TBI conditioning and cyclosporine (CsA) replacement with mycophenolate mofetil due to CsA nephrotoxicity, while other risk factors such as older patient age, the use of peripheral blood progenitor cells and donor/recipient sex mismatch were without statistical significance. | 24601700 |
| Malignant Neoplasms | Stem Cell Exhaustion | Effect of dedifferentiation on time to mutation acquisition in stem cell-driven cancers. | 24603301 |
| Carcinogenesis | Stem Cell Exhaustion | Our results suggest that dedifferentiation may play an important role in carcinogenesis, depending on how stem cell homeostasis is maintained. | 24603301 |
| Carcinogenesis | Stem Cell Exhaustion | If the stem cell population size is held strictly constant (due to all divisions being asymmetric), we found that dedifferentiation acts like a positive selective force in the stem cell population and thus speeds carcinogenesis. | 24603301 |
| Carcinogenesis | Stem Cell Exhaustion | Thus, dedifferentiation may play a crucial role, the common modeling assumption of constant stem cell population size may not be adequate, and further progress in understanding carcinogenesis demands a more detailed mechanistic understanding of stem cell homeostasis. | 24603301 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Accumulating evidence suggests that many tumors have a hierarchical organization, with the bulk of the tumor composed of relatively differentiated short-lived progenitor cells that are maintained by a small population of undifferentiated long-lived cancer stem cells. | 24603301 |
| Specialty Type - cancer | Stem Cell Exhaustion | It is unclear, however, whether cancer stem cells originate from normal stem cells or from dedifferentiated progenitor cells. | 24603301 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | A small population of cancer stem cells named the "side population" (SP) has been demonstrated to be responsible for the persistence of many solid tumors. | 24603487 |
| Failure, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | The resistance of leukemic stem cells to targeted therapies, such as tyrosine kinase inhibitors (TKIs), results in therapeutic failure or refractory/relapsed disease in chronic myeloid leukemia (CML). | 24603487 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | These results suggested that the expression of ABCG2 and the SP may be regulated by PTEN through the PI3K/Akt pathway, which would be a potentially effective strategy for targeting CML stem cells. | 24603487 |
| Primary Myelofibrosis | Stem Cell Exhaustion | Enhanced expression of Stim, Orai, and TRPC transcripts and proteins in endothelial progenitor cells isolated from patients with primary myelofibrosis. | 24603752 |
| Primary Myelofibrosis, PMF Regimen | Stem Cell Exhaustion | An increase in the frequency of circulating endothelial colony forming cells (ECFCs), the only subset of endothelial progenitor cells (EPCs) truly belonging to the endothelial phenotype, occurs in patients affected by primary myelofibrosis (PMF). | 24603752 |
| Bone Density, Osteoporosis, Senile | Stem Cell Exhaustion | The regressive biological function of human bone marrow-derived mesenchymal stem cells (hBMSCs) is one of the key factors resulting in the decrease of bone mass in senile osteoporosis. | 24604278 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | [Imatinib in combination with allogeneic hematopoietic stem cell transplantation improved the outcome of adult Philadelphia chromosome-positive acute lymphoblastic leukemia]. | 24606651 |
| B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1, BCR gene | Stem Cell Exhaustion | To investigate the role of imatinib in induction therapy for newly diagnosed adult patients with Philadephia chromosome-positive acute lymphoblastic leukemia (Ph+ALL), as well as the status of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in the treatment of adult Ph+ ALL in imatinib era. | 24606651 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | [Outcomes of imatinib and allogeneic hematopoietic stem cell transplantation in the treatment of chronic myeloid leukemia]. | 24606653 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | To compare the curative effect of imatinib and allogeneic hematopoietic stem cell transplant (allo-HSCT) in the treatment of chronic myeloid leukemia (CML). | 24606653 |
| Glycogen Storage Disease | Stem Cell Exhaustion | Biodistribution of adult derived human liver stem cells following intraportal infusion in a 17-year-old patient with glycogenosis type 1A. | 24607438 |
| Idiopathic pneumonia syndrome, Tumor necrosis | Stem Cell Exhaustion | Randomized, double-blind, placebo-controlled trial of soluble tumor necrosis factor receptor: enbrel (etanercept) for the treatment of idiopathic pneumonia syndrome after allogeneic stem cell transplantation: blood and marrow transplant clinical trials network protocol. | 24607553 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | Pharmacoeconomic analysis of palifermin to prevent mucositis among patients undergoing autologous hematopoietic stem cell transplantation. | 24607557 |
| Hematologic Neoplasms, Stomatitis | Stem Cell Exhaustion | Trials have shown benefits of palifermin in reducing the incidence and severity of oral mucositis in patients with hematological malignancies undergoing autologous hematopoietic stem cell transplantation (HSCT) with total body irradiation (TBI)-based conditioning regimens. | 24607557 |
| Clostridium difficile colitis, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Clostridium difficile infection in patients with acute myelogenous leukemia and in patients undergoing allogeneic stem cell transplantation: epidemiology and risk factor analysis. | 24607558 |
| Central Diabetes Insipidus, Clostridium difficile colitis, Diarrhea, Enterocolitis, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Patients receiving treatment for acute myelogenous leukemia (AML) and recipients of allogeneic stem cell transplantation (aSCT) are at high risk of contracting Clostridium difficile infection (CDI), the most frequently observed nosocomial diarrhea and enterocolitis. | 24607558 |
| Illness (finding) | Stem Cell Exhaustion | Cord blood eosinophil/basophil progenitor cells (Eo/B) of high risk infants have been shown to predict respiratory illnesses in infancy. | 24607604 |
| Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | Our findings demonstrate that CD44v6 is an important cancer stem cell-like marker associated with CaP proliferation, invasion, adhesion, metastasis, chemo-/radioresistance, and the induction of EMT as well as the activation PI3K/Akt/mTOR and Wnt signaling pathways, suggesting that CD44v6 is a novel therapeutic target to sensitize CaP cells to chemo/radiotherapy. | 24615685 |
| Respiratory Distress Syndrome, Newborn | Stem Cell Exhaustion | Intratracheal administration of umbilical cord blood-derived mesenchymal stem cells in a patient with acute respiratory distress syndrome. | 24616596 |
| Respiratory Distress Syndrome, Adult, Acute Lung Injury | Stem Cell Exhaustion | Umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) have been introduced as a possible therapy in acute lung injury and acute respiratory distress syndrome (ARDS). | 24616596 |
| Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | T-cell receptor excision circle levels after allogeneic stem cell transplantation are predictive of relapse in patients with acute myeloid leukemia and myelodysplastic syndrome. | 24617310 |
| malignant disease | Stem Cell Exhaustion | In this retrospective study, 209 patients with malignant disease were analyzed for levels of T-cell receptor excision circles (TRECs) for the first 24 months after allogeneic stem cell transplantation. | 24617310 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | This study shows the potential use of TREC measurement in blood to predict relapse in patients with AML and MDS after allogeneic hematopoietic stem cell transplantation. | 24617310 |
| Cytochrome-c Oxidase Deficiency | Stem Cell Exhaustion | We describe the natural history of clinical symptoms and brain imaging in two siblings with ACOX1 deficiency, including the younger sibling's response to allogeneic unrelated donor hematopoietic stem cell transplantation (HSCT). | 24619150 |
| Have Been Vomiting, Nausea | Stem Cell Exhaustion | Efficacy of aprepitant in preventing nausea and vomiting due to high-dose melphalan-based conditioning for allogeneic hematopoietic stem cell transplantation. | 24619827 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Underlying conditions were hematologic malignancy with or without hematopoietic stem cell transplant (n = 25), lung transplant (n = 3), or receipt of cytotoxic chemotherapy (n = 11). | 24621016 |
| Neutropenia, Bacteremia, Gastrointestinal mucositis | Stem Cell Exhaustion | Mucositis not neutropenia determines bacteremia among hematopoietic stem cell transplant recipients. | 24621081 |
| Neutropenia, Fever, Pregnancy Complications, Infectious | Stem Cell Exhaustion | In the 1960s, it was reported that infectious complications were the main cause of fever during neutropenia that followed hematopoietic stem cell transplant (HSCT). | 24621081 |
| Aggressive Non-Hodgkin Lymphoma | Stem Cell Exhaustion | In this study, we identified 260 cases of non-Burkitt, diffuse aggressive B-cell lymphomas from SWOG S9704, a phase 3 randomized study of standard immunochemotherapy versus autologous stem cell transplantation. | 24625415 |
| Stenotrophomonas maltophilia Measurement | Stem Cell Exhaustion | Stenotrophomonas maltophilia infection during allogeneic hematopoietic stem cell transplantation: a single-center experience. | 24628242 |
| Stenotrophomonas maltophilia Measurement, Communicable Diseases | Stem Cell Exhaustion | To examine risk factors for Stenotrophomonas maltophilia (S. maltophilia) infection during allogeneic hematopoietic stem cell transplantation (allo-HSCT), we retrospectively analyzed 259 patients who underwent allo-HSCT. | 24628242 |
| Multiple Myeloma | Stem Cell Exhaustion | Magnetic resonance imaging pattern of bone marrow involvement as a new predictive parameter of disease progression in newly diagnosed patients with multiple myeloma eligible for autologous stem cell transplantation. | 24628463 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | We investigated the prognostic value of the magnetic resonance imaging (MRI) pattern of bone marrow involvement in patients with multiple myeloma (MM) eligible for autologous stem cell transplantation (ASCT). | 24628463 |
| Hodgkin Disease | Stem Cell Exhaustion | F-18 FDG-PET predicts outcomes for patients receiving total lymphoid irradiation and autologous blood stem-cell transplantation for relapsed and refractory Hodgkin lymphoma. | 24628515 |
| Hodgkin Disease, LIPC gene | Stem Cell Exhaustion | Total lymphoid irradiation (TLI) followed by high-dose chemotherapy and autologous haematopoietic stem cell transplant (aHSCT) is an effective strategy for patients with relapsed/refractory classical Hodgkin lymphoma (HL). | 24628515 |
| Stomatitis, Multiple Myeloma | Stem Cell Exhaustion | The choice of multiple myeloma induction therapy affects the frequency and severity of oral mucositis after melphalan-based autologous stem cell transplantation. | 24629850 |
| Morular Metaplasia of the Endometrium, Gastrointestinal mucositis, Multiple Myeloma | Stem Cell Exhaustion | Mucositis is a common complication of high-dose melphalan (HDM) used before autologous stem cell transplantation (ASCT) for multiple myeloma (MM). | 24629850 |
| Idiopathic Pulmonary Fibrosis | Stem Cell Exhaustion | In contrast to progenitors isolated from nonfibrotic lungs, IPF mesenchymal progenitor cells produce daughter cells manifesting the full spectrum of IPF hallmarks, including the ability to form fibrotic lesions in zebrafish embryos and mouse lungs, and a transcriptional profile reflecting these properties. | 24631025 |
| Idiopathic Pulmonary Fibrosis | Stem Cell Exhaustion | Morphological analysis of IPF lung tissue revealed that mesenchymal progenitor cells and cells with the characteristics of their progeny comprised the fibrotic reticulum. | 24631025 |
| Idiopathic Pulmonary Fibrosis | Stem Cell Exhaustion | These data establish that the lungs of patients with IPF contain pathological mesenchymal progenitor cells that are cells of origin for fibrosis-mediating fibroblasts. | 24631025 |
| Specialty Type - cancer, Transitional cell carcinoma of bladder | Stem Cell Exhaustion | Expression and prognostic significance of cancer stem cell markers CD24 and CD44 in urothelial bladder cancer xenografts and patients undergoing radical cystectomy. | 24631171 |
| Malignant neoplasm of urinary bladder, Specialty Type - cancer | Stem Cell Exhaustion | To evaluate CD24/CD44/CD47 cancer stem cell marker expressions in bladder cancer (BCa) and provide data on their prognostic significance for clinical outcome in patients undergoing radical cystectomy (RC). | 24631171 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cell markers CD24/CD44/CD47 are differentially expressed in cells of urothelial BCa in patients undergoing RC and influence cancer-specific survival of patients. | 24631171 |
| Specialty Type - cancer | Stem Cell Exhaustion | We assessed overall and cause-specific mortality and risk factors for late mortality in a nation-wide population-based cohort of 4547 adult cancer patients who survived 2 or more years after receiving an autologous hematopoietic stem cell transplantation (HSCT) in Australia between 1992 and 2005. | 24631736 |
| Mycoses | Stem Cell Exhaustion | Incidence and outcome of invasive fungal diseases after allogeneic stem cell transplantation: a prospective study of the Gruppo Italiano Trapianto Midollo Osseo (GITMO). | 24631738 |
| Mycoses | Stem Cell Exhaustion | Epidemiologic investigation of invasive fungal diseases (IFDs) in allogeneic hematopoietic stem cell transplantation (allo-HSCT) may be useful to identify subpopulations who might benefit from targeted treatment strategies. | 24631738 |
| Myeloma cell | Stem Cell Exhaustion | Lymphocyte subset recovery and outcome after autologous hematopoietic stem cell transplantation for plasma cell myeloma. | 24631739 |
| Cholangiolocellular Carcinoma | Stem Cell Exhaustion | Cholangiolocellular carcinoma (CoCC) has distinct pathological characteristics, and CoCC is considered to originate from hepatic progenitor or stem cells. | 24633664 |
| Bronchiolitis Obliterans, bottle - unit dose | Stem Cell Exhaustion | Bronchiolitis obliterans (BO) is a devastating complication of allogeneic hematopoietic stem cell transplantation (HSCT). | 24634108 |
| Secondary Malignant Neoplasm, Central neuroblastoma | Stem Cell Exhaustion | Secondary malignant neoplasms after high-dose chemotherapy and autologous stem cell rescue for high-risk neuroblastoma. | 24634399 |
| Secondary Malignant Neoplasm | Stem Cell Exhaustion | Modern treatment protocols utilizing intense induction followed by myeloablative consolidation chemotherapy with autologous stem cell rescue (ASCR) have improved survival rates, but the long-term sequelae, including development of secondary malignant neoplasms (SMN), are just now surfacing. | 24634399 |
| HIV-1 Infection Pathway | Stem Cell Exhaustion | The first cure of HIV-1 infection was achieved through complex, multimodal therapy including myeloablative chemotherapy, total body irradiation, anti-thymocyte globulin, and allogeneic stem cell transplantation with a CCR5 delta32 homozygous donor. | 24638072 |
| Vascular Diseases | Stem Cell Exhaustion | A novel potential therapy for vascular diseases: blood-derived stem/progenitor cells specifically activated by dendritic cells. | 24638886 |
| Histiocytosis, Langerhans-Cell | Stem Cell Exhaustion | Haploidentical parental hematopoietic stem cell transplantation in pediatric refractory Langerhans cell histiocytosis. | 24641492 |
| Arterial Stiffness, Hypertensive (finding) | Stem Cell Exhaustion | Circulating endothelial progenitor cells in hypertensive patients with increased arterial stiffness. | 24641802 |
| Hypertension, CTCAE | Stem Cell Exhaustion | The potential association between arterial stiffening and circulating endothelial progenitor cells (EPCs) in patients with essential hypertension was investigated. | 24641802 |
| Specialty Type - cancer | Stem Cell Exhaustion | The isoform 1 (ALDH1) has been proved useful for the identification of cancer stem cells. | 24643706 |
| Contrast - Induced Nephropathy | Stem Cell Exhaustion | Reduction of circulating endothelial progenitor cell level is associated with contrast-induced nephropathy in patients undergoing percutaneous coronary and peripheral interventions. | 24646509 |
| Reduced Number, Chronic Kidney Disease, CTCAE | Stem Cell Exhaustion | Reduced number and impaired function of circulating endothelial progenitor cells (EPCs) in patients with chronic kidney disease have been reported. | 24646509 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | Reduced intensity conditioning and oral care measures prevent oral mucositis and reduces days of hospitalization in allogeneic stem cell transplantation recipients. | 24647488 |
| Gastrointestinal mucositis, Oman | Stem Cell Exhaustion | Oral mucositis (OM) is a side effect of intensive chemotherapy and radiation and has been reported to affect 75-100% of hematopoietic stem cell transplantation (HSCT) recipients. | 24647488 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Multicenter study evaluating the impact of hypomethylating agents as bridging therapy to hematopoietic stem cell transplantation in myelodysplastic syndromes. | 24648120 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (alloSCT) is currently the only curative treatment modality for myelodysplastic syndromes (MDS). | 24648120 |
| Specialty Type - cancer | Stem Cell Exhaustion | Recently, the cancer stem cell hypothesis has become widely accepted. | 24650343 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells are thought to possess the ability to undergo self-renewal and differentiation, similar to normal stem cells. | 24650343 |
| Graft-vs-Host Disease, Hematological Disease | Stem Cell Exhaustion | In a multicenter collaboration, we carried out T cell-replete, peripheral blood stem cell (PBSC) transplantations from related, HLA-haploidentical donors with reduced-intensity conditioning (RIC) and post-transplantation cyclophosphamide (Cy) as graft-versus-host disease (GVHD) prophylaxis in 55 patients with high-risk hematologic disorders. | 24650678 |
| Hematological Disease | Stem Cell Exhaustion | Peripheral blood hematopoietic stem cells for transplantation of hematological diseases from related, haploidentical donors after reduced-intensity conditioning. | 24650678 |
| Amyloidosis | Stem Cell Exhaustion | Induction bortezomib in Al amyloidosis followed by high dose melphalan and autologous stem cell transplantation: a single institution retrospective study. | 24650974 |
| Amyloidosis | Stem Cell Exhaustion | High-dose melphalan (HDM) followed by autologous stem cell transplant (ASCT) for light chain amyloidosis (AL) was performed in 31 patients at Oregon Health and Science University between 2005 and 2012. | 24650974 |
| Allogeneic Hematopoietic Stem Cell Transplantation, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Outcome of patients with abnl(17p) acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation. | 24652988 |
| leukemia, Fred Hutchinson/University of Washington Cancer Consortium, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | To accurately define the outcome after allogeneic hematopoietic stem cell transplantation (HSCT) in patients with abnl(17p) AML, we analyzed the results of patients with this abnormality who received an allogeneic HSCT between January 2000 and December 2010 in 1 of 4 well-defined cohorts (Fred Hutchinson Cancer Research Center, Haemato Oncology Foundation for Adults in the Netherlands, Study Alliance Leukemia, German Cooperative Transplant Study Group). | 24652988 |
| Disease, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Myelodysplastic syndromes (MDS) are stem cell disorders that can progress to acute myeloid leukemia. | 24652987 |
| Mantle cell lymphoma | Stem Cell Exhaustion | One hundred sixty untreated, stage II-IV mantle cell lymphoma patients <66 years received rituximab (R)-maxi-CHOP (cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone) alternating with R-high-dose cytarabine (6 cycles total), followed by high-dose BEAM/C (bis-chloroethylnitrosourea, etoposide, cytarabine, and melphalan or cyclophosphamide) and autologous stem cell transplantation from 2005 to 2009. | 24652994 |
| Hematologic Neoplasms | Stem Cell Exhaustion | This qualitative study of survivors of allogeneic stem cell transplantation (SCT) for haematological malignancy explored attitudes about late effects of therapy, healthcare issues and information needs. | 24654219 |
| Toxic effect | Stem Cell Exhaustion | Feasibility of the fludarabine busulfan 3 days and ATG 2 days reduced toxicity conditioning in 51 allogeneic hematopoietic stem cell transplantation: a single-center experience. | 24655805 |
| Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | We evaluated the impact of detection of minimal residual disease by flow cytometry (FCMRD) and CD3 chimerism in relapse in a cohort of 87 patients with acute myeloid leukemia or myelodysplastic syndrome undergoing stem cell transplantation. | 24655806 |
| Osteoporosis | Stem Cell Exhaustion | The gene expression profile of primary osteoporosis GSE35956 was downloaded from the GEO (Gene Expression Omnibus) database and included five MSC (mesenchymal stem cell) specimens of normal osseous tissue and five MSC specimens of osteoporosis. | 24656062 |
| Diffuse alveolar hemorrhage | Stem Cell Exhaustion | Recombinant human factor VIIa for alveolar hemorrhage following allogeneic stem cell transplantation. | 24657447 |
| Diffuse alveolar hemorrhage | Stem Cell Exhaustion | The mortality rate of alveolar hemorrhage (AH) after allogeneic hematopoietic stem cell transplantation is greater than 60% with supportive care and high-dose steroid therapy. | 24657447 |
| Communicable Diseases, Multiple Organ Failure, primary disorders | Stem Cell Exhaustion | In patients with AH following hematopoietic stem cell transplantation, clinical factors (ie, worsening infection, multiple organ failure, or recrudescence of primary disease) may be more important than the benefit of enhanced hemostasis from rFVIIa. | 24657447 |
| Febrile Neutropenia | Stem Cell Exhaustion | Evaluation of febrile neutropenia in patients undergoing hematopoietic stem cell transplantation. | 24658984 |
| Fever | Stem Cell Exhaustion | The aim of this study was to determine the incidence and causes of fever as a major problem contributing to transplantation related mortality among patients undergoing hematopoietic stem cell transplantation (HSCT) and evaluation of antibiotic use, according to reliable guidelines.We retrospectively reviewed hospital records of 195 adult patients who underwent HSCT between 2009-2011 at hematology-oncology and bone marrow transplantation research center. | 24658984 |
| Febrile Neutropenia, Fever, Communicable Diseases | Stem Cell Exhaustion | The hospital stay duration was directly related to the numbers of fever episodes (P<0.0001).The rate of febrile episodes in autologous stem cell transplantation was significantly higher compared to allogeneic type (P<0.05).It is necessary to determine not only the local profile of microbiologic pattern, but also antibiotic sensitivities in febrile neutropenic patients following hematopoietic stem cell transplantation, and reassess response to antibiotic treatment to establish any necessity for modifications to treatment guidelines in order to prevent any fatal complications from infection. | 24658984 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cells, as a subgroup of tumor cells, resemble critical properties of embryonic stem cells (ESCs) such as self-renewal and maintenance of stemness state. | 24659265 |
| Abnormal, Neoplasms | Stem Cell Exhaustion | Sox2, one of the genes that maintains self-renewal of embryonic stem cells and relates to the differentiation potential of these cells, is abnormaly expressed in various human tumors. | 24659665 |
| Decreased platelet count | Stem Cell Exhaustion | A period of thrombocytopenia is common after stem cell transplantation (SCT). | 24660761 |
| Hodgkin Disease | Stem Cell Exhaustion | Efficacy of just-in-time plerixafor rescue for Hodgkin's lymphoma patients with poor peripheral blood stem cell mobilization. | 24660786 |
| Lymphoma, Non-Hodgkin, Multiple Myeloma | Stem Cell Exhaustion | Plerixafor is a Food and Drug Administration-approved agent for improving peripheral blood stem cell (PBSC) mobilization in filgrastim (granulocyte-colony-stimulating factor [G-CSF])-stimulated patients with multiple myeloma and non-Hodgkin's lymphoma. | 24660786 |
| Adult Myelodysplastic Syndrome, Acute leukemia | Stem Cell Exhaustion | Donor-derived myelodysplastic syndrome and acute leukaemia after allogeneic haematopoietic stem cell transplantation: incidence, natural history and treatment response. | 24661075 |
| Acute Myeloid Leukemia with Myelodysplasia-Related Changes | Stem Cell Exhaustion | Donor-derived myelodysplastic syndrome/acute leukaemia (DD-MDS/AL) is a rare life-threatening complication of allogeneic haematopoietic stem cell (HSC) transplantation. | 24661075 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | Intensified chemo-immunotherapy with or without stem cell transplantation in newly diagnosed patients with peripheral T-cell lymphoma. | 24662801 |
| Clostridium difficile colitis | Stem Cell Exhaustion | Early Clostridium difficile infection during allogeneic hematopoietic stem cell transplantation. | 24662889 |
| Clostridium difficile colitis, Central Diabetes Insipidus | Stem Cell Exhaustion | Clostridium difficile infection (CDI) is frequently diagnosed in recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 24662889 |
| Multiple Myeloma | Stem Cell Exhaustion | Survival of multiple myeloma patients aged 65-70 years in the era of novel agents and autologous stem cell transplantation. | 24662986 |
| Intrinsic Factor Deficiency, Mycoses | Stem Cell Exhaustion | Despite the recent introduction of a new class of anti-Aspergillus agents, no standard regimen for the prevention of invasive fungal disease (IFD) following allogeneic hematopoietic stem cell transplantation has been shown to be superior to fluconazole. | 24664791 |
| Neoplasms, Medulloblastoma | Stem Cell Exhaustion | Tandem high-dose chemotherapy and autologous stem cell rescue in children with newly diagnosed high-risk medulloblastoma or supratentorial primitive neuro-ectodermic tumors. | 24664937 |
| Supratentorial Embryonal Tumor, Not Otherwise Specified, Medulloblastoma | Stem Cell Exhaustion | To assess the feasibility and effectiveness of high-dose chemotherapy (HDC) with stem cell support followed by conventional craniospinal radiotherapy (RT) as treatment for children older than 5 years of age with newly diagnosed high-risk medulloblastoma (MB) or supratentorial PNET (sPNET). | 24664937 |
| Bone marrow hypocellularity | Stem Cell Exhaustion | Androgens are a standard therapeutic option for bone marrow failure in those patients with DC who are unable to undergo haematopoietic stem cell transplantation, but there are no systematic data on its use in those patients. | 24666134 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Acute myeloid leukemia (AML) is a heterogeneous clonal disorder of hemopoietic progenitor cells diagnosed in individuals of any age, but with a median age of 67 years at presentation in adults. | 24666762 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Biphasic modulation of cancer stem cell-driven solid tumour dynamics in response to reactivated replicative senescence. | 24666838 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | We have developed an agent-based model of solid tumour growth whose input population composition is based on the cancer stem-cell hypothesis. | 24666838 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | It is used to show how cancer stem cells can drive tumour progression, while non-stem cancer cells (CCs) interfere with this by impeding cancer stem-cell dynamics. | 24666838 |
| Cessation of life, Neoplasms | Stem Cell Exhaustion | Model simulations reveal that reactivation of the replicative senescence programme in CCs initially increases total tumour burden, as attrition from cell death is partially averted, but evolves to provide tumour control in the long-term through increasing constraints on stem-cell compartment kinetics. | 24666838 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Reactivation of replicative senescence can prolong CC competition with cancer stem cells, thereby ultimately inhibiting malignant progression regardless of tumour size. | 24666838 |
| Chronic Kidney Disease, CTCAE, Old age | Stem Cell Exhaustion | Mesenchymal stem cells from rats with chronic kidney disease exhibit premature senescence and loss of regenerative potential. | 24667162 |
| Specialty Type - cancer | Stem Cell Exhaustion | IGF-II/IGF1R signalling blockade inhibits Nanog expression and attenuates cancer stem cell features. | 24668028 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells (CSCs) are a promising target for treating cancer, yet how CSC plasticity is maintained in vivo is unclear and is difficult to study in vitro. | 24668028 |
| Neoplasms | Stem Cell Exhaustion | Here we establish a sustainable primary culture of Oct3/4(+)/Nanog(+) lung CSCs fed with CD90(+) cancer-associated fibroblasts (CAFs) to further advance our knowledge of preserving stem cells in the tumour microenvironment. | 24668028 |
| Chronic Kidney Disease, CTCAE | Stem Cell Exhaustion | Chronic kidney disease after autologous stem cell transplantation: analysis of a single center experience. | 24668138 |
| Chronic Kidney Diseases, Chronic Kidney Disease, CTCAE | Stem Cell Exhaustion | Chronic kidney disease (CKD) after allogeneic hematopoietic stem cell transplantation (HSCT) has increasingly been reported. | 24668138 |
| Pilomatrixoma, Neoplasms | Stem Cell Exhaustion | We aimed at studying cortical differentiation, beta-catenin pathway and expression of the follicular stem-cell marker PHLDA1 in a series of matrical tumors other than pilomatricoma. | 24673383 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Intensive chemotherapy and reduced-intensity allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia in elderly patients. | 24673966 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | This retrospective study assessed the outcomes of older patients with AML treated with intensive chemotherapy with or without allogeneic hematopoietic stem cell transplantation (HSCT). | 24673966 |
| Acute GVH disease, Histocompatibility Antigens Class I | Stem Cell Exhaustion | [A comparison of clinical characteristics and prognosis of adult acute graft-versus-host disease between human leukocyte antigen- identical and -mismatched allogeneic hematopoietic stem cell transplantation]. | 24674726 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | To compare the clinical characteristics and prognosis of acute graft-versus-host disease (aGVHD) between patients undergoing human leukocyte antigen (HLA)-identical and HLA-mismatched allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 24674726 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | This may be related to an insufficient targeting of the CD44(high)CD24(low) breast cancer stem cell subset, which is not only highly resistant to chemotherapy and radiotherapy but also a poor target for trastuzumab due to low HER2 surface expression. | 24675467 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | This revealed that CD44(high)CD24(low)HER2(low) stem cell-like breast cancer cells show high endocytic activity and are thus particularly sensitive towards the antibody-drug conjugate T-DM1. | 24675467 |
| Neoplasms | Stem Cell Exhaustion | Moreover, when tumor cells were cocultured with natural killer cells, antibody-dependent cell-mediated cytotoxicity was enhanced, and EMT-mediated induction of stem cell-like properties was prevented in differentiated tumor cells. | 24675467 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Thus our study reveals an unanticipated targeting of stem cell-like breast cancer cells by T-DM1 that may contribute to the clinical efficacy of this recently approved antibody-drug conjugate. | 24675467 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Targeting of preexisting and induced breast cancer stem cells with trastuzumab and trastuzumab emtansine (T-DM1). | 24675467 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Consequently, preexisting CD44(high)CD24(low) cancer stem cells were depleted by concentrations of T-DM1 that did not affect the bulk of the tumor cells. | 24675467 |
| Neoplasms, Malignant Neoplasms | Stem Cell Exhaustion | Chemokines are involved in both the negative and positive regulation of inflammatory processes, angiogenesis and cancer/cancer stem cell proliferation as well as the chemoattraction of tumor cells to metastatic sites. | 24676787 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | In this study we aimed to isolate stem-like cells from freshly resected LCa tumor specimens and characterize them by quantitative real time PCR (qRT-PCR) for expression of cancer stem cell markers including SOX2, OCT4, KLF4, ABCG2, CXCR4 and CD44. | 24678693 |
| Fusariosis, Aplastic Anemia | Stem Cell Exhaustion | Fatal Fusarium solani infection after stem cell transplant for aplastic anemia. | 24679137 |
| Aplastic Anemia | Stem Cell Exhaustion | A 21-year-old man with aplastic anemia was treated with an allogeneic stem cell transplant. | 24679137 |
| Nonunion of Bone | Stem Cell Exhaustion | Treatment of humeral shaft aseptic nonunions in elderly patients with opposite structural allograft, BMP-7, and mesenchymal stem cells. | 24679209 |
| Nonunion of Bone | Stem Cell Exhaustion | This study reports the authors' experience using opposite cortical allograft combined with bone morphogenetic protein 7 and mesenchymal stem cells to treat humeral shaft atrophic nonunions in 2 elderly patients. | 24679209 |
| Non-Malignant | Stem Cell Exhaustion | The use of a locking plate and opposite cortical allograft, combined with BMP-7 and mesenchymal stem cells, represents a safe and effective treatment for malignant nonunions in older patients. | 24679209 |
| Specialty Type - cancer | Stem Cell Exhaustion | Furthermore, miR-203 may regulate the expressions of mesenchymal transition (EMT) marker of E-cadherin and cancer stem cells (CSCs) marker of CD44. | 24682952 |
| Aggressive Non-Hodgkin Lymphoma, Medial collateral ligament, Mantle cell lymphoma | Stem Cell Exhaustion | Mantle cell lymphoma (MCL) is an aggressive B cell lymphoma, where survival has been remarkably improved by use of protocols including high dose cytarabine, rituximab and autologous stem cell transplantation, such as the Nordic MCL2/3 protocols. | 24684350 |
| Lymphoproliferative Disorders | Stem Cell Exhaustion | Comparative analysis of post-transplant lymphoproliferative disorder after kidney transplantation versus hematopoietic stem cell transplantation. | 24684689 |
| Post-transplant lymphoproliferative disorder | Stem Cell Exhaustion | This single center retrospective study enrolled 41 adult PTLD patients after kidney-transplantation (KT, n = 28) and hematopoietic stem cell transplantation (HSCT, n = 13) from 1992 to 2012. | 24684689 |
| Depression, CTCAE, Acute Coronary Syndrome | Stem Cell Exhaustion | Impact of depression on circulating endothelial progenitor cells in patients with acute coronary syndromes: a pilot study. | 24685963 |
| GDC AJCC Clinical Stage Terminology | Stem Cell Exhaustion | The number of endothelial progenitor cells (EPCs) is an independent predictor of clinical outcomes in patients with ACS. | 24685963 |
| Hematopoietic stem cells | Stem Cell Exhaustion | Controlled-rate freezing and storage in vapour phase nitrogen are used by most transplantation teams for the cryopreservation and storage of peripheral blood haematopoietic stem cells (PBSC). | 24686987 |
| Hemorrhagic cystitis | Stem Cell Exhaustion | The objective of the study was to study the characteristics of patients suffering hemorrhagic cystitis after hematopoietic stem cell transplantation in our center. | 24691038 |
| Specialty Type - cancer | Stem Cell Exhaustion | microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells. | 24691539 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells (CSCs) may be one of the causes of therapeutic resistance, but the molecular mechanism underlying this resistance is unclear. | 24691539 |
| Specialty Type - cancer, Medulloblastoma | Stem Cell Exhaustion | SHH, WNT, and NOTCH pathways in medulloblastoma: when cancer stem cells maintain self-renewal and differentiation properties. | 24695855 |
| Medulloblastoma, Neoplasms, Neuroepithelial | Stem Cell Exhaustion | Infant medulloblastoma (MB) is a malignant neuroepithelial embryonal tumor of the cerebellum, believed to derive from precursor granule cells with stem or progenitor cells appearance, and caused by a change in expression profile of genes related to the development. | 24695855 |
| Specialty Type - cancer | Stem Cell Exhaustion | Increasing evidence supports the important role of cancer stem cells (CSCs). | 24696843 |
| Liver carcinoma, Specialty Type - cancer, Hollings Cancer Center | Stem Cell Exhaustion | Many reports suggest that epithelial cell adhesion molecule (EpCAM) is a useful marker for cancer stem cells in hepatocellular carcinoma (HCC). | 24696843 |
| Specialty Type - cancer | Stem Cell Exhaustion | To elucidate the mechanisms of cancer stem cells, the development of specific molecular targeted drugs has become very important. | 24696843 |
| Specialty Type - cancer, Hepatitis B | Stem Cell Exhaustion | Collectively, our results suggest that cancer stem cells are highly expressed in hepatitis B and have potential anticancer drug resistance. | 24696843 |
| Dermis, Myeloid Stem Cell, Acute leukemia | Stem Cell Exhaustion | We report a case of a 45-year-old man who developed extramedullary acute leukemia with a myeloid immunophenotype (myeloid sarcoma) with its initial presentation within an isolated pre-existing osteoma cutis in the post-auricular scalp without evidence of systemic acute leukemia or chronic myeloid stem cell disorders. | 24698478 |
| End Stage Liver Disease | Stem Cell Exhaustion | Clinical outcome of autologous hematopoietic stem cell infusion via hepatic artery or portal vein in patients with end-stage liver diseases. | 24698673 |
| Hepatobiliary Disorder | Stem Cell Exhaustion | To investigate the efficacy of hematopoietic stem cell (HSC) transplantation via the hepatic artery vs. the portal vein for end-stage liver disease (ESLD). | 24698673 |
| Italy, Multiple Myeloma | Stem Cell Exhaustion | We analyzed the main modalities and clinical outcomes of the early discharge outpatient model in autologous stem cell transplantation (EDOM-ASCT) for multiple myeloma in Italy. | 24699116 |
| Carcinoma | Stem Cell Exhaustion | The re-expression of pluripotent markers (Oct-4 and Nanog) and the reactivation of stem cell-related pathways in oral carcinoma have been well researched. | 24700702 |
| Specialty Type - cancer | Stem Cell Exhaustion | However, the relationship between the stem cell signaling molecule b-catenin and pluripotent markers Oct-4 and Nanog in oral cancer is yet to be studied in detail. | 24700702 |
| Cerebral Infarction, Decreased platelet count | Stem Cell Exhaustion | Acute cerebral infarct with elevated factor VIII level during the thrombocytopenic stage after hematopoietic stem cell transplant. | 24702151 |
| Thromboembolism | Stem Cell Exhaustion | Thromboembolism is a complication of hematopoietic stem cell transplant. | 24702151 |
| Cerebral Infarction, Decreased platelet count | Stem Cell Exhaustion | However, a literature search showed no previous reports of cerebral infarction during the thrombocytopenic stage after hematopoietic stem cell transplant. | 24702151 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | A 35-year-old woman with acute lymphoblastic leukemia (precursor B-cell type) was treated with hematopoietic stem cell transplant after induction and consolidation chemotherapy. | 24702151 |
| Thromboembolism | Stem Cell Exhaustion | This case suggests that prudent treatment of patients who have hematopoietic stem cell transplant may include monitoring for thromboembolism and testing factor VIII level before transplant. | 24702151 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Prognostic impact of minimal residual disease analysis by flow cytometry in patients with acute myeloid leukemia before and after allogeneic hemopoietic stem cell transplantation. | 24702162 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Allogeneic stem cell transplantation (allo-SCT) has become the treatment of choice in patients with intermediate-risk and high-risk acute myeloid leukemia (AML). | 24702162 |
| Liver carcinoma, Liver Cirrhosis, Hepatocellular Small Cell Change | Stem Cell Exhaustion | Investigation of diagnostic utility and expression profiles of stem cell markers (CD133 and CD90) in hepatocellular carcinoma, small cell dysplasia, and cirrhosis. | 24702884 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | N-Cadherin and Tie2 positive CD34+CD38-CD123+ leukemic stem cell populations can develop acute myeloid leukemia more effectively in NOD/SCID mice. | 24703771 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Emerging studies suggest that the population of malignant cells found in human acute myelogenous leukemia (AML) arises from a rare population of leukemic stem cells (LSCs). | 24703771 |
| Stable chronic Graft vs Host Disease, Immune-mediated, Chronic graft-versus-host disease | Stem Cell Exhaustion | Chronic graft-versus-host disease (cGVHD) is an immune-mediated disorder and is the major long-term complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 24704387 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit. | 24704494 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | Here, we show that patient-derived mesenchymal stromal cells (MDS MSCs) display a disturbed differentiation program and are essential for the propagation of MDS-initiating Lin(-)CD34(+)CD38(-) stem cells in orthotopic xenografts. | 24704494 |
| Hematopoietic stem cells, MYELODYSPLASTIC SYNDROME, Myeloid neoplasm | Stem Cell Exhaustion | Myelodysplastic syndromes (MDSs) are a heterogeneous group of myeloid neoplasms with defects in hematopoietic stem and progenitor cells (HSPCs) and possibly the HSPC niche. | 24704494 |
| Infectious Lung Disorder | Stem Cell Exhaustion | The predictive value for pulmonary infection by area over the neutrophil curve (D-index) in patients who underwent reduced intensity hematopoietic stem cell transplantation. | 24705712 |
| Infectious Lung Disorder | Stem Cell Exhaustion | We evaluated the predictive value of the D-index for pulmonary infection in the early phase of reduced intensity stem cell transplantation (RIST). | 24705712 |
| Sepsis | Stem Cell Exhaustion | Endothelial progenitor cells and a stromal cell-derived factor-1a analogue synergistically improve survival in sepsis. | 24707934 |
| Sepsis | Stem Cell Exhaustion | Endothelial progenitor cells (EPCs) have been associated with human sepsis but their role is incompletely understood. | 24707934 |
| Respiratory Distress Syndrome, Newborn | Stem Cell Exhaustion | Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study. | 24708472 |
| Lung Injury | Stem Cell Exhaustion | Recent studies have demonstrated that mesenchymal stem cells (MSCs) modulate the immune response and reduce lung injury in animal models. | 24708472 |
| Graft-vs-Host Disease, Acute on chronic graft-versus-host disease | Stem Cell Exhaustion | Both acute and chronic graft-versus-host disease (GVHD) are major causes of morbidity and mortality in patients undergoing allogeneic hematopoietic stem cell transplantation (AHSCT). | 24709007 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | In patients with AML, the use of G-CSF after auto-SCT is not associated with increased risk of relapse irrespective of the source of stem cells used. | 24710564 |
| Necrosis | Stem Cell Exhaustion | [Stem cell implant with neck-head decompression for aseptic necrosis of the femoral head]. | 24712191 |
| Necrosis | Stem Cell Exhaustion | An observational, descriptive, prospective, case-series type of study was conducted to prove the hypothesis that the boring decompression of the femoral neck-head cancellous layer, together with the local implantation of multipotent adult autologous stem cells processed according to Ficoll at approximate amounts of 16.1 x 10(6) cells/ml, is the treatment of choice for stages I-II-III of aseptic necrosis of the femoral head. | 24712191 |
| Experimental Organism Malignant Hepatocholangiocellular Carcinoma | Stem Cell Exhaustion | Clinicopathological significance of 'subtypes with stem-cell feature' in combined hepatocellular-cholangiocarcinoma. | 24712771 |
| Hollings Cancer Center | Stem Cell Exhaustion | According to the WHO classification 2010, we surveyed the prevalence and clinicopathological significance of each subtype with stem-cell features [SC subtype; typical subtype (TS), intermediate cell subtype (INT) and cholangiolocellular type (CLC)] in cHC-CC and HCC. | 24712771 |
| Hollings Cancer Center, Experimental Organism Malignant Hepatocholangiocellular Carcinoma, Malignant neoplasm of liver, Liver carcinoma, Cholangiocarcinoma | Stem Cell Exhaustion | Combined hepatocellular-cholangiocarcinoma (cHC-CC), a malignant liver tumour with poor prognosis, is composed of hepatocellular carcinoma (HCC), cholangiocarcinoma (CC) and diverse components with intermediate features between HCC and CC, which correspond to hepatic progenitor cells. | 24712771 |
| Concomitant Medication Submission Domain, Tumor necrosis, diabetic | Stem Cell Exhaustion | In CM derived from CD34+ cells of diabetic individuals (diabetic-CM), the levels of stem cell factor, hepatocyte growth factor, and thrombopoietin were lower, and IL-1b and tumor necrosis factor (TNFa) levels were higher than CM derived from nondiabetic individuals (nondiabetic-CM). | 24713821 |
| Diabetes, Hypoxia, Specific antibody deficiency | Stem Cell Exhaustion | We hypothesized that endothelial progenitor cells derived from individuals with diabetes would exhibit functional defects including inability to respond to hypoxia and altered paracrine/autocrine function that would impair the angiogenic potential of these cells. | 24713821 |
| diabetic | Stem Cell Exhaustion | Circulating mononuclear cells isolated from diabetic (n = 69) and nondiabetic (n = 46) individuals were used to grow endothelial colony forming cells (ECFC), early endothelial progenitor cells (eEPCs) and isolate CD34+ cells. | 24713821 |
| Hypoxia | Stem Cell Exhaustion | Enhanced expression of transcription factor hypoxia inducible factor HIF-1a is known to play a critical role in the modulation of cell metabolism and survival pathways as well as having stem-cell-like properties. | 24715760 |
| Hypoxia, Pterygium | Stem Cell Exhaustion | Pterygium, a stem cell disorder with premalignant features, has been reported to demonstrate hypoxia. | 24715760 |
| Sarcoma - category (morphologic abnormality) | Stem Cell Exhaustion | In vitro biosafety profile evaluation of multipotent mesenchymal stem cells derived from the bone marrow of sarcoma patients. | 24716831 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | In the context of hematopoietic stem cell transplantation (HSCT), mesenchymal stem cells (MSC) have been used to promote engraftment and prevent graft-versus-host disease. | 24717223 |
| Usual Severity Pain | Stem Cell Exhaustion | The patient received chemotherapy, which alleviated his limb pain, and achieved stringent complete remission after autologous peripheral blood stem cell transplantation. | 24717597 |
| Glioblastoma Multiforme Pathway, Glioma, Specialty Type - cancer | Stem Cell Exhaustion | The objective of this study is to investigate the expression level of periostin in cancer stem cells as well as in the glioma tissues and the relationship between periostin expression and clinical and pathological characteristics and prognosis of gliomas. | 24719188 |
| Rheumatoid Arthritis, Degenerative polyarthritis | Stem Cell Exhaustion | Osteoblastic potential of infrapatellar fat pad-derived mesenchymal stem cells from rheumatoid arthritis and osteoarthritis patients. | 24720504 |
| Rheumatoid Arthritis, Degenerative polyarthritis, Tumor necrosis | Stem Cell Exhaustion | To evaluate the osteoblastic potential of adipose-derived mesenchymal stem cells (ASCs) from infrapatellar fat pad (IPFP) of rheumatoid arthritis (RA) patients in comparison to osteoarthritis (OA) patients, as well as the influence of tumor necrosis factor alpha (TNFa) on osteoblastic ASC differentiation in vitro. | 24720504 |
| Multiple Myeloma | Stem Cell Exhaustion | The osteoblastogenesis potential of adipose mesenchymal stem cells in myeloma patients who had received intensive therapy. | 24722177 |
| Multiple Myeloma | Stem Cell Exhaustion | OBs are derived from mesenchymal stem cells (MSCs) from the bone marrow (BM), however the pool and function of BMMSCs in MM patients (MM-BMMSCs) are reduced by myeloma cells (MCs) and cytokines secreted from MCs and related anti-MM treatment. | 24722177 |
| Congenital dyserythropoietic anemia, type II | Stem Cell Exhaustion | Successful hematopoietic stem cell transplantation in a patient with congenital dyserythropoietic anemia type II. | 24724984 |
| Peripheral Stem Cell Transplantation, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Early lymphocyte recovery at 28 d post-transplant is predictive of reduced risk of relapse in patients with acute myeloid leukemia transplanted with peripheral blood stem cell grafts. | 24725056 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We evaluated the impact of lymphocyte recovery at 28 d post-HCT in 191 AML patients using peripheral blood stem cells as graft. | 24725056 |
| Hematopoietic stem cells, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We report an unusual case of a 34-year-old patient with acute myeloid leukaemia, status post-allogenic hematopoietic stem cell transplantation who subsequently developed GvHD with skin involvement. | 24725497 |
| Immune System Diseases | Stem Cell Exhaustion | Patients who undergo allogeneic stem cell transplantation frequently develop an immunologic disease caused by the reactivation of the graft to the host tissues. | 24727333 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Comparable long-term outcome of unrelated cord blood transplantation with related bone marrow or peripheral blood stem cell transplantation in patients aged 45 years or older with hematologic malignancies after myeloablative conditioning. | 24727335 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Clinical outcomes of 97 patients aged 45 years or older with hematologic malignancies who received unrelated cord blood transplantation (CBT) (n = 66) or bone marrow transplantation (BMT) or peripheral blood stem cell transplantation (PBSCT) from related donors (n = 31) were compared. | 24727335 |
| Malignant neoplasm of ovary, Specialty Type - cancer | Stem Cell Exhaustion | DDX4 (DEAD box polypeptide 4) colocalizes with cancer stem cell marker CD133 in ovarian cancers. | 24727449 |
| Malignant neoplasm of ovary, Specialty Type - cancer | Stem Cell Exhaustion | We investigated the relationship between DDX4 and ovarian cancer stem cells by analyzing the expression patterns of DDX4 and the cancer stem cell marker CD133 in ovarian cancers via tissue microarray. | 24727449 |
| Malignant neoplasm of ovary, Specialty Type - cancer | Stem Cell Exhaustion | Furthermore, almost all CD133 positive ovarian cancer cells also express DDX4 whereas CD133-negative cells did not possess DDX4, suggesting a strong possibility that DDX4 plays an important role in cancer stem cells, and/or can be used as an ovarian cancer stem cell marker. | 24727449 |
| Hematopoietic stem cells, Unknown (origin) (qualifier value), Bone marrow hypocellularity, Aplastic Anemia | Stem Cell Exhaustion | The majority of cases of aplastic anemia remain idiopathic, although hematopoietic stem cell deficiency and impaired immune responses are hallmarks underlying the bone marrow failure in this condition. | 24727813 |
| Aplastic Anemia | Stem Cell Exhaustion | We found that mesenchymal stem cell cultures can be established from the bone marrow of aplastic anemia patients and display the same phenotype and differentiation potential as their counterparts from normal bone marrow. | 24727813 |
| Aplastic Anemia | Stem Cell Exhaustion | Bone marrow mesenchymal stem cells from patients with aplastic anemia maintain functional and immune properties and do not contribute to the pathogenesis of the disease. | 24727813 |
| Aplastic Anemia | Stem Cell Exhaustion | We investigated whether bone marrow mesenchymal stem cells contribute, directly or indirectly, to the pathogenesis of aplastic anemia. | 24727813 |
| Aplastic Anemia | Stem Cell Exhaustion | Mesenchymal stem cells from aplastic anemia patients support the in vitro homeostasis and the in vivo repopulating function of CD34(+) cells, and maintain their immunosuppressive and anti-inflammatory properties. | 24727813 |
| Aplastic Anemia | Stem Cell Exhaustion | These data demonstrate that bone marrow mesenchymal stem cells from patients with aplastic anemia do not have impaired functional and immunological properties, suggesting that they do not contribute to the pathogenesis of the disease. | 24727813 |
| Multiple Myeloma | Stem Cell Exhaustion | Early response-based intensification of primary therapy in newly diagnosed multiple myeloma patients who are eligible for autologous stem cell transplantation: phase II study. | 24728664 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | This phase II study prospectively evaluated the efficacy and tolerability of an early change in induction therapy before autologous stem cell transplantation (ASCT) in multiple myeloma (MM) patients who failed to achieve more than a partial response (PR) after two cycles of a cyclophosphamide, thalidomide, and dexamethasone (CTD) regimen. | 24728664 |
| Respiratory Tract Infections | Stem Cell Exhaustion | Viral respiratory infections diagnosed by multiplex PCR after allogeneic hematopoietic stem cell transplantation: long-term incidence and outcome. | 24732781 |
| Respiratory Tract Infections | Stem Cell Exhaustion | Viral respiratory infections (VRIs) are frequent after hematopoietic stem cell transplantation and constitute a potential cause of mortality. | 24732781 |
| Harvesting of peripheral blood stem cells, Pulmonary Embolism, Deep Vein Thrombosis, Heparin-induced thrombocytopenia, Amyloid nephropathy, Upper Extremity Deep Vein Thrombosis | Stem Cell Exhaustion | A 63-year-old Caucasian man with renal amyloidosis undergoing peripheral blood stem cell collection for an autologous stem cell transplant developed extensive bilateral upper-extremity deep venous thrombosis (DVT) and pulmonary embolism secondary to heparin-induced thrombocytopenia. | 24733133 |
| Multiple Myeloma | Stem Cell Exhaustion | Patients with multiple myeloma who had undergone a haematopoietic stem cell transplantation and subsequent treatment for at least one episode of progressive disease but were in stable plateau phase were included in the study. | 24733635 |
| Vascular Diseases | Stem Cell Exhaustion | Endothelial progenitor cells (EPCs) are implicated in protection against vascular disease. | 24736282 |
| Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | However, recent studies have challenged the relative importance of these canonical cellular responses for p53-mediated tumour suppression and have highlighted roles for p53 in modulating other cellular processes, including metabolism, stem cell maintenance, invasion and metastasis, as well as communication within the tumour microenvironment. | 24739573 |
| CLU protein, human, Ischemia | Stem Cell Exhaustion | We tested the hypothesis that clopidogrel and cilostazol combination therapy could effectively attenuate systemic inflammatory reaction, facilitate proliferation of circulating endothelial progenitor cell (EPC), and improve the clinical outcomes of critical limb ischemia (CLI) in patients unsuitable for surgical revascularization or percutaneous transluminal angioplasty (PTA). | 24742198 |
| Ulcer | Stem Cell Exhaustion | As compared with the baseline, circulating endothelial progenitor cell level (as shown by flow cytometry) was significantly increased (p<0.003), whereas the CLI-related ulcers and painfulness were significantly improved (all p<0.01) by day 90 after treatment. | 24742198 |
| Ischemia | Stem Cell Exhaustion | Levels and values of lipoprotein-associated phospholipase A2, galectin-3, RhoA/ROCK, and endothelial progenitor cells in critical limb ischemia: pharmaco-therapeutic role of cilostazol and clopidogrel combination therapy. | 24742198 |
| Ductal Carcinoma, Malignant Neoplasms | Stem Cell Exhaustion | CD44+/CD24-low cases (cases that reveal stem cell-phenotype) in the group of invasive ductal carcinoma of Luminal A molecular subtype are almost as many as CD44+/CD24+ and CD44-/CD24+ phenotype cancers. | 24743129 |
| Malignant Neoplasms | Stem Cell Exhaustion | In this group non-stem phenotype cases are 65%, so 5 times more than stem cell phenotype cancers. | 24743129 |
| Aggressive behavior | Stem Cell Exhaustion | Stem cell phenotype positive cases are with the highest percentage represented in Luminal B and basal-like molecular subgroup that to our minds is associated with their aggressive behavior and resistance to chemotherapy. | 24743129 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | With regard to the dimension of cancer the analysis of stem cell phenotype cancers showed that frequency of stem cell phenotype (CD44+/CD24-low) dramatically increases from T1 to T4 cancers. | 24743129 |
| Malignant Neoplasms | Stem Cell Exhaustion | High density of stem cell phenotype cancers in cancers with metastatic lymphatic nodes proves that presence of mentioned phenotype plays a role in progression and dissemination. | 24743129 |
| Malignant Neoplasms | Stem Cell Exhaustion | On the one hand, little amount of stem cells phenotype cancers (CD44+/CD24-low), on the other hand absence of negative cases for markers of stem cell in Her2 subtype makes us consider that come phenotype, close to stem-cell phenotype, plays the leading role in Her2 positive cases. | 24743129 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells are the only cells with ability of unlimited proliferative activity and cancerous potential, thus, they participate in the growth, progression and dissemination of cancer. | 24743129 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells are resistant to various forms of therapy, including chemotherapy and radiotherapy . | 24743129 |
| Malignant Neoplasms | Stem Cell Exhaustion | Relatively good prognosis and response to chemotherapy of Luminal A molecular subtype cancers are to be stipulated by lower percentage of cases with stem cells phenotype. | 24743129 |
| Degenerative polyarthritis | Stem Cell Exhaustion | The application of mesenchymal stem cells (MSCs) has been proposed as a new treatment option for OA based on the ability of these cells to differentiate into chondrocytes. | 24743139 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Elevated TIM3+ hematopoietic stem cells in untreated myelodysplastic syndrome displayed aberrant differentiation, overproliferation and decreased apoptosis. | 24746294 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Changes in mast cell number and stem cell factor expression in human skin after radiotherapy for breast cancer. | 24746564 |
| Neutropenia, Aspergillosis | Stem Cell Exhaustion | After allogeneic stem cell transplantation patients are at risk of invasive aspergillosis, especially during the period of neutropenia. | 24747947 |
| Werner Syndrome | Stem Cell Exhaustion | Telomerase protects werner syndrome lineage-specific stem cells from premature aging. | 24749076 |
| Meningitis, Cryptococcal | Stem Cell Exhaustion | Cryptococcal meningitis post autologous stem cell transplantation. | 24750320 |
| Meningitis, Cryptococcal | Stem Cell Exhaustion | Cryptococcal meningitis following autologous stem cell transplant (SCT) has been described previously in only 1 patient, 4 months post SCT and while off antifungal prophylaxis. | 24750320 |
| Disease, Conjunctival Neoplasms, Dryness of eye | Stem Cell Exhaustion | The utility of impression cytology in ocular diseases has predominantly been restricted to the diagnosis of dry eye, limbal stem cell deficiency and conjunctival neoplasias. | 24750348 |
| B-Cell Lymphomas | Stem Cell Exhaustion | R-ESHAP plus pegfilgrastim as an effective peripheral stem cell mobilization regimen for autologous stem-cell transplantation in patients with relapsed/refractory diffuse large B-cell lymphoma. | 24751603 |
| Lymphoma | Stem Cell Exhaustion | Stem cell (SC) mobilization is significantly influenced by the mobilization schedule in patients with lymphoma. | 24751603 |
| SERPINA1 wt Allele | Stem Cell Exhaustion | In conclusion, although serum AAT levels and HSPC mobilization in healthy stem cell donors are positively correlated, AAT is not an indispensable protease-inhibitor in the constitutive circulation of HSPC. | 24752699 |
| alpha 1-Antitrypsin Deficiency | Stem Cell Exhaustion | Peripheral blood hematopoietic stem and progenitor cell frequency is unchanged in patients with alpha-1-antitrypsin deficiency. | 24752699 |
| Adult Leiomyosarcoma, Fanconi Anemia | Stem Cell Exhaustion | Primary intracranial leiomyosarcoma of the torcular Herophili associated with Fanconi anemia and allogenic stem cell transplantation. | 24752708 |
| Adult Leiomyosarcoma, Fanconi Anemia | Stem Cell Exhaustion | A 12-year-old girl with Fanconi anemia presented with a primary intracranial leiomyosarcoma arising from the torcular Herophili and infiltrating the adjacent venous sinuses after previous allogenic hematopoietic stem cell transplantation. | 24752708 |
| Prion Diseases | Stem Cell Exhaustion | Since affected tissues in age-associated disorders and in pathological aging are mainly of mesenchymal origin we propose a model of human aging based on mesenchymal stem cells (hMSCs) which accumulate prelamin A. | 24753226 |
| Mutation Rate, Carcinogenesis | Stem Cell Exhaustion | Patient age is positively correlated with somatic mutation frequency, suggesting that some poly-G variants accumulate before the onset of carcinogenesis during normal division in colonic stem cells. | 24753616 |
| Prostate carcinoma | Stem Cell Exhaustion | Circulating endothelial progenitor cells in castration resistant prostate cancer: a randomized, controlled, biomarker study. | 24755958 |
| Hypoxia | Stem Cell Exhaustion | Severe hypoxia exerts parallel and cell-specific regulation of gene expression and alternative splicing in human mesenchymal stem cells. | 24758227 |
| Specialty Type - cancer, Laryngeal Squamous Cell Carcinoma | Stem Cell Exhaustion | Clinicopathological significance of cancer stem cells marked by CD133 and KAI1/CD82 expression in laryngeal squamous cell carcinoma. | 24758564 |
| Secondary Neoplasm, Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Presently, CD133 is one of the hottest markers to characterize cancer stem cells and KAI1/CD82 is reported as an important marker for the metastasis and prognosis of many cancers. | 24758564 |
| Specialty Type - cancer, Laryngeal Squamous Cell Carcinoma | Stem Cell Exhaustion | The purpose of our study is to explore the relationship between cancer stem cells (CSCs) marked by CD133 and KAI1/CD82 expression and the clinicopathological characteristics of patients with laryngeal squamous cell carcinoma (LSCC). | 24758564 |
| Fever, Abdominal Pain | Stem Cell Exhaustion | A 41-year-old man with fever and abdominal pain after stem-cell transplantation. | 24758620 |
| Lymphoma | Stem Cell Exhaustion | [Clinical analysis of 81 cases of malignant lymphoma treated with autologous hematopoietic stem cell transplantation]. | 24759022 |
| Lymphoma | Stem Cell Exhaustion | To investigated the curative effect of autologous hematopoietic stem cell transplantation (ASCT) for malignant lymphoma. | 24759022 |
| Hematopoietic stem cells | Stem Cell Exhaustion | High dose of etoposide combined with G-CSF was used to mobilize peripheral hematopoietic stem cell. | 24759022 |
| Precursor cell lymphoblastic lymphoma | Stem Cell Exhaustion | [Clinical outcome of autologous stem cell transplantation as first-line treatment in 30 patients with high risk lymphoblastic lymphoma]. | 24759023 |
| Precursor cell lymphoblastic lymphoma | Stem Cell Exhaustion | To investigate the treatment outcomes of autologous stem cell transplantation (ASCT) as first-line treatment in patients with high risk lymphoblastic lymphoma (LBL) and compare the effect of different induction regimen on prognosis. | 24759023 |
| Hypertensive (finding) | Stem Cell Exhaustion | Because gene microarrays had failed to detect many stem cell-associated genes, we performed quantitative real-time PCR to measure the expression of 45 primitive and tissue differentiation markers in PBMCs from healthy and hypertensive human subjects. | 24759906 |
| Coronary heart disease, Platelet aggregation | Stem Cell Exhaustion | Effects of simvastatin/ezetimibe on microparticles, endothelial progenitor cells and platelet aggregation in subjects with coronary heart disease under antiplatelet therapy. | 24760119 |
| Platelet aggregation | Stem Cell Exhaustion | Simvastatin/ezetimibe diphosphate did not change platelet aggregation, the amount of circulating endothelial and platelet microparticles, or endothelial progenitor cells. | 24760119 |
| Platelet aggregation | Stem Cell Exhaustion | Cardiovascular protection following therapy with simvastatin/ezetimibe seems restricted to lipid changes and improvement of endothelial function not affecting the release of microparticles, mobilization of endothelial progenitor cells or decreased platelet aggregation. | 24760119 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Cell-based therapies have recently been proposed for the treatment of degenerative articular pathologies, such as early osteoarthritis, with an emphasis on autologous mesenchymal stem cells (MSCs), as an alternative to terminally differentiated cells. | 24760577 |
| Platelet aggregation | Stem Cell Exhaustion | to investigate hemostatic parameter changes, such as platelet aggregation, blood and plasma viscosity, prothrombin time, APTT, CRP and fibrinogen, before and after administration of stem cell therapy. | 24760803 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Hemostatic status of pre and post intracoronary injection of peripheral blood stem cells in patients with recent myocardial infarction. | 24760803 |
| Heart failure | Stem Cell Exhaustion | Alteration of Notch signaling and functionality of adipose tissue derived mesenchymal stem cells in heart failure. | 24767126 |
| Vascular System Injuries | Stem Cell Exhaustion | The endothelial progenitor cell (EPC) plays an important role in repairing vascular injury. | 24768407 |
| Hemorrhagic cystitis | Stem Cell Exhaustion | Relationship of BK polyoma virus (BKV) in the urine with hemorrhagic cystitis and renal function in recipients of T Cell-depleted peripheral blood and cord blood stem cell transplantations. | 24769326 |
| Renal dysfunction, CLTC gene, Hemorrhagic cystitis | Stem Cell Exhaustion | Hematopoietic stem cell transplant (HSCT) recipients are at significant risk for BK virus (BKV) reactivation, hemorrhagic cystitis (HC), and renal dysfunction. | 24769326 |
| Specialty Type - cancer, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Stem Cell Exhaustion | Prognostic significance of ALDH1A1-positive cancer stem cells in patients with locally advanced, metastasized head and neck squamous cell carcinoma. | 24770634 |
| Prediabetes syndrome | Stem Cell Exhaustion | Endothelial progenitor cells as a cardiometabolic risk factor marker in prediabetes. | 24776624 |
| Atherosclerosis | Stem Cell Exhaustion | Endothelial progenitor cells (EPCs) have recently been considered as a potential novel marker of vascular integrity, atherosclerosis and cardiovascular risk. | 24776624 |
| Multiple Myeloma | Stem Cell Exhaustion | Complete response after autologous stem cell transplant in multiple myeloma. | 24777883 |
| Multiple Myeloma | Stem Cell Exhaustion | We evaluated long-term outcome of patients achieving complete response (CR) after autologous stem cell transplantation (ASCT) for multiple myeloma. | 24777883 |
| Gastrointestinal Stromal Tumors, Mesenchymal Cell Neoplasm | Stem Cell Exhaustion | Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract, believed to originate from the interstitial cells of Cajal or their stem cell-like precursors. | 24778033 |
| Gastrointestinal Stromal Tumors | Stem Cell Exhaustion | Based on antibody screening, we observed a positive correlation between the expression of GIST marker stem cell growth factor receptor, also known as tyrosine-protein kinase KIT or CD117, and STAM2 expression (r=0.387, p<0.003). | 24778033 |
| Neoplasms, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Chronic myeloid leukemia (CML) is a stem cell (SC) neoplasm characterized by the BCR/ABL1 oncogene. | 24778155 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia. | 24778155 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | For decades now, it is well established that chronic myeloid leukemia (CML) is a hematopoietic stem cell(HPC) disorder. | 24779036 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | After allogeneic stem cell transplantation, graft-versus-host disease (GvHD) occurs through recognition of histocompatibility mismatches by donor T lymphocytes. | 24781016 |
| Muscular Dystrophy, Duchenne, Muscle Weakness | Stem Cell Exhaustion | Duchenne muscular dystrophy (DMD) patients lack dystrophin from birth; however, muscle weakness becomes apparent only at 3-5 years of age, which happens to coincide with the depletion of the muscle progenitor cell (MPC) pools. | 24781208 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Allogeneic stem cell transplantation for mantle cell lymphoma--final report from the prospective trials of the East German Study Group Haematology/Oncology (OSHO). | 24782119 |
| Medial collateral ligament, Mantle cell lymphoma | Stem Cell Exhaustion | This study was conducted in order to evaluate allogeneic stem cell transplantation (alloSCT) as consolidation for patients with mantle cell lymphoma (MCL). | 24782119 |
| Neoplasms | Stem Cell Exhaustion | It has been hypothesized that the hair bulge stem cells may be responsible for the broad spectrum of histological variation in these tumors. | 24786577 |
| Peroxisome biogenesis disorders | Stem Cell Exhaustion | These findings indicate the presence of a bidirectional differentiation--secretory and squamous--within the same lesion, thus supporting the hypothesis that PBD and primary EMPD may arise from a common progenitor cell. | 24786579 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Long term follow-up of BEAM-autologous and BEAM-alemtuzumab allogeneic stem cell transplantation in relapsed advanced stage follicular lymphoma. | 24787231 |
| Lymphoma, Follicular | Stem Cell Exhaustion | This is an analysis in 171 patients comparing BEAM-Auto and BEAM-Allo (alemtuzumab)-hematopoietic stem cell transplantation in relapsed follicular lymphoma. | 24787231 |
| Malignant neoplasm of lung, Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cell marker Musashi-1 rs2522137 genotype is associated with an increased risk of lung cancer. | 24787949 |
| Specialty Type - cancer | Stem Cell Exhaustion | However, the potential role of genetic polymorphisms of cancer stem cell (CSC) marker genes with respect to cancer risk has not been examined. | 24787949 |
| Anemia, Sickle Cell | Stem Cell Exhaustion | First successful allogeneic hematopoietic stem cell transplantation for a sickle cell disease patient in a low resource country (Nigeria): a case report. | 24792997 |
| Anemia, Sickle Cell | Stem Cell Exhaustion | We present our first allogeneic hematopoietic stem cell transplantation (HSCT) for a 7-year-old patient with severe sickle cell anemia and debilitating right-sided hemi-paraparesis. | 24792997 |
| Anemia, Sickle Cell, Anemia | Stem Cell Exhaustion | We have successfully performed a stem cell transplanted in a 7-year-old Sickle Cell Anemia case. | 24792997 |
| Neoplasms, Medulloblastoma | Stem Cell Exhaustion | Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. | 24796395 |
| Medulloblastoma | Stem Cell Exhaustion | Importantly JQ1 suppresses stem cell associated signaling in medulloblastoma cells and inhibits medulloblastoma tumor cell self-renewal. | 24796395 |
| Medulloblastoma | Stem Cell Exhaustion | Our work indicates that BRD4 inhibition attenuates stem cell signaling in MYC driven medulloblastoma and demonstrates the feasibility BET domain inhibition as a therapeutic approach in vivo. | 24796395 |
| Bacteremia, Multiple Myeloma | Stem Cell Exhaustion | Impact of a change in antibacterial prophylaxis on bacteremia and hospitalization rates following outpatient autologous peripheral blood stem cell transplantation for multiple myeloma. | 24797543 |
| Bacterial Infections | Stem Cell Exhaustion | Levofloxacin is routinely used for the prevention of invasive bacterial infections during autologous peripheral blood stem cell transplantation (APBSCT). | 24797543 |
| Neutropenia | Stem Cell Exhaustion | Feasibility and effectiveness of posaconazole prophylaxis in combination with micafungin bridging for patients undergoing allogeneic stem cell transplantation: a 6-yr analysis from the cologne cohort for neutropenic patients. | 24798021 |
| Mycoses | Stem Cell Exhaustion | Invasive fungal diseases (IFDs) are an important cause of morbidity and mortality in patients undergoing allogeneic stem cell transplantation (SCT). | 24798021 |
| Acute leukemia | Stem Cell Exhaustion | Who is the best hematopoietic stem-cell donor for a male patient with acute leukemia? | 24798307 |
| Li-Fraumeni Syndrome, Disease remission | Stem Cell Exhaustion | Factors significantly associated with reduced LFS included active disease, poor cytogenetics, age, year of hematopoietic stem-cell transplantation, reduced-intensity conditioning, and the use of antithymocyte globulin. | 24798307 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Identification of campath-1 (CD52) as novel drug target in neoplastic stem cells in 5q-patients with MDS and AML. | 24799522 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We asked whether neoplastic stem cells (NSC) in patients with MDS (n = 29) or acute myelogenous leukemia (AML; n = 62) express CD52. | 24799522 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Ex vivo molecular rejuvenation improves the therapeutic activity of senescent human cardiac stem cells in a mouse model of myocardial infarction. | 24801508 |
| Self-control as a personality trait | Stem Cell Exhaustion | Examine associations between self-regulatory fatigue, quality of life, and health behaviors in patients pre- (N = 213) and 1-year post-hematopoietic stem cell transplantation (HSCT; N = 140). | 24802991 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Current studies on cancer stem cells (CSCs) have verified that CSCs are the driving force behind tumor initiation and progression, suggesting that new cancer therapies may be established by effectively targeting and killing the CSCs. | 24804195 |
| Liver carcinoma, Hollings Cancer Center | Stem Cell Exhaustion | Recent studies from Asia have implicated SALL4, a stem cell marker, as useful in identifying aggressive cases of hepatocellular carcinoma (HCC), and >50% of the cases tested had upregulation by microarray or dense immunoreactivity. | 24805857 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | In this study, we aimed to investigate the role of stem cell factor (SCF)/C-KIT signaling in regulating the expression of tryptase in AML cells. | 24806698 |
| Multiple Myeloma | Stem Cell Exhaustion | Comparison of outcomes after autologous stem cell transplantation between myeloma patients with skeletal and soft tissue plasmacytoma. | 24813053 |
| Plasmacytoma - category, Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | We aimed to compare the characteristics of skeletal and soft tissue plasmacytomas and to analyze clinical outcomes and prognostic factors of autologous stem cell transplantation (ASCT) in multiple myeloma (MM) patients with plasmacytoma. | 24813053 |
| Graft-vs-Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Although older patients undergoing allogeneic hematopoietic stem cell transplantation (HCT) may experience higher morbidity, the impact of chronic graft-versus-host disease (GVHD) on quality of life (QOL) and survival outcomes for older compared with younger patients is currently unknown. | 24813171 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Cancer stem cells or tumour-propagating cells (TPCs) have been identified for a number of cancers, but data pertaining to their existence in lymphoma so far remain elusive. | 24814516 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | We selected 64 patients with pathological primary lung N2 SqCC who underwent surgical complete resection and investigated the expressions of four epithelial-mesenchymal transition-related markers (caveolin, clusterin, E-cadherin, ZEB2), three cancer stem cell-related markers (ALDH-1, CD44 variant6, podoplanin) of cancer cells, and four markers of CAFs (caveolin, CD90, clusterin, podoplanin) in both primary and matched metastatic lymph node tumors in the N2 area. | 24814677 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Intravenous busulfan for autologous stem cell transplantation in adult patients with acute myeloid leukemia: a survey of 952 patients on behalf of the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation. | 24816236 |
| Toxic effect, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | However intravenous busulfan has more predictable pharmacokinetics and less toxicity than oral busulfan; we, therefore, retrospectively analyzed data from 952 patients with acute myeloid leukemia who received intravenous busulfan for autologous stem cell transplantation. | 24816236 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Our results suggest that the use of intravenous busulfan simplifies the autograft procedure and confirm the usefulness of autologous stem cell transplantation in acute myeloid leukemia. | 24816236 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | UM-SCC-103: a unique tongue cancer cell line that recapitulates the tumorigenic stem cell population of the primary tumor. | 24816422 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | CD44(high) cancer stem cells from UM-SCC-103 formed tumors after flank injections in mice that reconstituted the heterogeneity of the primary tumor. | 24816422 |
| SERPINB3 wt Allele | Stem Cell Exhaustion | Moreover, HSBP1 elevated expression of stem cell markers such as CD44, CD133, ALDH and SOX2, and subsequently enhanced mammosphere formation ability, indicating it drives stem cell-like status in OSCC cells. | 24816843 |
| Leukemia, Myelomonocytic, Chronic | Stem Cell Exhaustion | Chronic myelomonocytic leukaemia (CMML) is a haematopoietic stem cell malignancy delineated by genetic heterogeneity. | 24817963 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Mesenchymal stem cells (MSCs) have limited clinical therapeutic effects in older myocardial infarction (MI) patients. | 24818643 |
| Crohn Disease | Stem Cell Exhaustion | [Successful autologous haematopoietic stem cell transplantation in severe, therapy-resistant childhood Crohn's disease. | 24819188 |
| Inflammatory Bowel Diseases | Stem Cell Exhaustion | Hematopoietic stem cell transplantation has emerged as a new potential therapeutic tool for inflammatory bowel diseases. | 24819188 |
| Crohn Disease | Stem Cell Exhaustion | To the best of knowledge of the authors, this is the first report in Hungary presenting hematopoietic stem cell therapy in patient with severe Crohn's disease. | 24819188 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | Mononuclear stem cells have been studied for their potential in myocardial ischemia. | 24819720 |
| H1N1, Hematologic Neoplasms, Influenza, Communicable Diseases | Stem Cell Exhaustion | Patients with haematological malignancies receiving concurrent treatment or after allogeneic stem cell transplantation (HSCT) are considered to be at increased risk for acquiring influenza A (H1N1) infection (pH1N1) and influenza-associated complications leading to increased mortality. | 24824490 |
| ARSA wt Allele | Stem Cell Exhaustion | Moreover, after excluding patients receiving an allogeneic stem cell transplantation in first CR, MLD was associated with a shorter survival (HR, 95 % CI = 1.599, 1.026-2.492; p = 0.038). | 24824767 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Aldehyde dehydrogenase 1 (ALDH1) has been regarded as a breast cancer stem cell marker. | 24824938 |
| Sample Size Calculation | Stem Cell Exhaustion | Seventeen patients with IP associated with SSc received autologous peripheral blood stem cell transplantation (auto-PBSCT) and were followed up using HRCT and pulmonary function tests. | 24824977 |
| Trauma | Stem Cell Exhaustion | Mobilization of CD34+-progenitor cells in patients with severe trauma. | 24826895 |
| Inflammatory Bowel Diseases | Stem Cell Exhaustion | Toll-like receptor expression in crypt epithelial cells, putative stem cells and intestinal myofibroblasts isolated from controls and patients with inflammatory bowel disease. | 24828022 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Intensive chemotherapy and consolidation with high dose therapy and autologous stem cell transplant in patients with mantle cell lymphoma. | 24828864 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | A bortezomib-containing regimen followed by high-dose therapy and autologous stem cell transplant (ASCT) is considered the standard of care for front-line therapy in younger patients with newly diagnosed multiple myeloma (MM). | 24828869 |
| Depression, CTCAE, Anxiety Disorders, Coma, Post-Head Injury, Physical and emotional exhaustion state | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (HSCT) is curative in several life-threatening pediatric diseases but may affect children and their families inducing depression, anxiety, burnout symptoms, and post-traumatic stress symptoms, as well as post-traumatic growth (PTG). | 24830676 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | The clinical and financial burden of pre-emptive management of cytomegalovirus disease after allogeneic stem cell transplantation-implications for preventative treatment approaches. | 24831837 |
| Cytomegalovirus Infections, Toxic effect, Communicable Diseases | Stem Cell Exhaustion | Although cytomegalovirus (CMV) infection after allogeneic stem cell transplantation (SCT) is rarely fatal, the management of CMV by pre-emptive medication for viral reactivation has toxicity and carries a financial burden. | 24831837 |
| Specialty Type - cancer, Esophageal Neoplasms | Stem Cell Exhaustion | It has been suggested that markers associated with cancer stem cells (CSC) may play a role in esophageal cancer. | 24833101 |
| Infection, Immune System Diseases | Stem Cell Exhaustion | B-cell immune dysfunction contributes to the risk of severe infections after allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 24833353 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | These high rates of locoregional recurrence are potentially influenced by the contribution of radioresistant cancer stem cells to these cancers. | 24833589 |
| Rheumatoid Arthritis | Stem Cell Exhaustion | Neutralisation of CCL28 in RA SF or blockade of CCR10 on human endothelial progenitor cells (EPCs) significantly reduced SF-induced endothelial migration and capillary formation, demonstrating that ligation of joint CCL28 to endothelial CCR10+ cells is involved in RA angiogenesis. | 24833787 |
| Cholangiocarcinoma | Stem Cell Exhaustion | Markers of the stem cell phenotype in cholangiocarcinoma, HepPar1 and CK20, were negative in all cases. | 24837095 |
| Acute leukemia | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (HSCT) is the mainstay of treatment for adults with acute leukemia. | 24837891 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Upfront allogeneic stem cell transplantation after reduced-intensity/nonmyeloablative conditioning for patients with myelodysplastic syndrome: a study by the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire. | 24838178 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Cytoreduction before allogeneic stem cell transplantation (allo-SCT) for patients with myelodysplastic syndromes remains a debatable issue. | 24838178 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Acute and chronic myeloid leukemia are initiated and sustained by a small, self-renewing population of leukemic stem cells, which produce progeny of a heterogeneous population of progenitor cells. | 24839815 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Acute graft-versus-host disease (aGVHD) remains a life-threatening complication of hematopoietic stem cell transplantation (HSCT) therefore limiting its application. | 24840443 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | A multicompartment mathematical model of cancer stem cell-driven tumor growth dynamics. | 24840956 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | As a central tenet of the so-called cancer stem cell hypothesis, most cancer cells have only a limited lifespan, and thus cannot initiate or reinitiate tumors. | 24840956 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | We show that overall tumor progression rate during the exponential growth phase is identical to the growth rate of the cancer stem cell compartment. | 24840956 |
| Neoplasms | Stem Cell Exhaustion | Tumors with identical stem cell proportions, however, can have different growth rates, dependent on the proliferation kinetics of all participating cell populations. | 24840956 |
| Longevity, Specialty Type - cancer | Stem Cell Exhaustion | Longevity and clonogenicity are properties unique to the subpopulation of cancer stem cells. | 24840956 |
| Specialty Type - cancer | Stem Cell Exhaustion | To understand the implications of the population structure suggested by this hypothesis--a hierarchy consisting of cancer stem cells and progeny non-stem cancer cells which experience a reduction in their remaining proliferation capacity per division--we set out to develop a mathematical model for the development of the aggregate population. | 24840956 |
| LMNA wt Allele | Stem Cell Exhaustion | In this study, using SMCs differentiated from HGPS induced pluripotent stem cells, we show that HGPS SMCs exhibit a profound proliferative defect, which is primarily caused by caspase-independent cell death. | 24843141 |
| Specialty Type - cancer | Stem Cell Exhaustion | These findings provide a valuable mechanistic basis for studying the process of asymmetric inheritance in mammalian cells, including cells potentially undergoing polar divisions, such as differentiating stem cells and cancer cells. | 24843142 |
| Antilymphocyte Serum | Stem Cell Exhaustion | Here we show that intrathecal transplantation of human motor neurons derived from neural stem cells (NSCs) in spinal cord of the SOD1G93A mouse ALS model delayed disease onset and extended life span of the animals. | 24844281 |
| HLA Mismatch, Graft-vs-Host Disease | Stem Cell Exhaustion | Mismatch on glutathione S-transferase T1 increases the risk of graft-versus-host disease and mortality after allogeneic stem cell transplantation. | 24844856 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Predictive value of risk assessment scores in patients with hematologic malignancies undergoing reduced-intensity conditioning allogeneic stem cell transplantation. | 24845702 |
| Toxic effect | Stem Cell Exhaustion | Reduced-intensity conditioning allogeneic stem cell transplantation (RIC allo-SCT) is associated with less toxicity and is used for older patients. | 24845702 |
| leukemia | Stem Cell Exhaustion | Leukocyte interleukin-3 receptor a (CD123) is regarded as a marker of leukemia stem cells. | 24846193 |
| Neurobehavioral problems | Stem Cell Exhaustion | Cross-sectional study of patient-reported neurobehavioral problems following hematopoietic stem cell transplant and health-related quality of life. | 24846770 |
| Neurobehavioral problems, Impaired cognition, Apathy | Stem Cell Exhaustion | Although hematopoietic stem cell transplant (HSCT) patients may experience neurocognitive impairment, experiences of neurobehavioral problems (including apathy and disinhibition) are understudied. | 24846770 |
| Specialty Type - cancer | Stem Cell Exhaustion | A strong debate in the Literature is open about a higher risk of cancer relapse caused by growth factors produced by adipocyte stem cells after their engraftment in the recipient tissue. | 24847895 |
| Specialty Type - cancer | Stem Cell Exhaustion | New insights into skin stem cell aging and cancer. | 24849235 |
| Inflammation | Stem Cell Exhaustion | Recently, we identified novel roles of Substance-P (SP) in the suppression of the injury-mediated inflammation and also in stem cell mobilization. | 24849674 |
| Osteoporosis, melphalan/prednisone protocol | Stem Cell Exhaustion | Therefore, this comparative study suggests that SP, even after long-term usage of effective dose, may not cause side effects such as osteoporosis in comparison to that of DEX and MP and can be developed as an anti-inflammatory agent and/or stem cell mobilizer for long-term treatment. | 24849674 |
| Malignant neoplasm of salivary gland | Stem Cell Exhaustion | Most importantly, WIF1 significantly diminished the number of salivary gland cancer stem cells and the anchorage-independent cell growth. | 24853424 |
| Mammary adenocarcinoma | Stem Cell Exhaustion | We further show that the knockdown of NDY1 in mammary adenocarcinoma cell lines decreased the number, size, and replating efficiency of mammospheres and downregulated the stem cell markers ALDH and CD44, while upregulating CD24. | 24853546 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells. | 24853546 |
| Adenocarcinoma, Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Together, these findings suggest that NDY1 is required for the self-renewal of cancer stem cells and are in agreement with additional findings showing that tumor cells in which NDY1 was knocked down undergo differentiation and a higher number of them is required to induce mammary adenocarcinomas, upon orthotopic injection in animals. | 24853546 |
| Graft-vs-Host Disease, Hematopoietic stem cells, Epithelial Damage | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (HSCT) is widely used to treat hematopoietic cell disorders but is often complicated by graft-versus-host disease (GVHD), which causes severe epithelial damage. | 24855210 |
| Multiple Myeloma | Stem Cell Exhaustion | This multicenter, open-label phase 2 trial determined the safety and efficacy of carfilzomib, a novel and irreversible proteasome inhibitor, in combination with cyclophosphamide and dexamethasone (CCyd) in patients with newly diagnosed multiple myeloma (NDMM) >=65 years of age or who were ineligible for autologous stem cell transplantation. | 24855212 |
| Specialty Type - cancer | Stem Cell Exhaustion | In unadjusted analyses, lack of FP therapy prior to cancer treatment, older age, partnered relationship, higher income, no history of stem cell or bone marrow transplant, and longer duration of survivorship were significantly associated with pregnancy attempts. | 24859010 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5), a marker of adult stem cells and cancer stem cells, plays important roles in tumor progression. | 24859092 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | CD4 regulatory T cells play a critical role in establishment of immune tolerance and prevention of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. | 24859877 |
| Chronic graft-versus-host disease | Stem Cell Exhaustion | Mitochondrial priming is increased after hematopoietic stem cell transplantation in all T-cell subsets and particularly in patients with chronic graft-versus-host disease. | 24859877 |
| Mitochondrial Inheritance | Stem Cell Exhaustion | Decreased expression of BCL2 and increased expression of BIM, a mitochondrial cell death activator protein, in regulatory T cells contributes to increased mitochondrial priming in this T-cell subset but additional factors likely contribute to increased mitochondrial priming following hematopoietic stem cell transplantation. | 24859877 |
| Neutropenia, Graft-vs-Host Disease, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Posaconazole (PSC) is currently recommended as primary prophylaxis in neutropenic patients with acute myeloid leukaemia (AML) and in allogenic haematopoietic stem cell transplantation (AHSCT) recipients with graft-versus-host disease (GVHD). | 24861577 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | After allogeneic stem cell transplantation (SCT), a reliable diagnosis of acute graft versus host disease (aGvHD) is essential for an early and successful treatment. | 24863887 |
| Lymphoproliferative Disorders | Stem Cell Exhaustion | Utility of quantitative EBV DNA measurements in cerebrospinal fluid for diagnosis and monitoring of treatment of central nervous system EBV-associated post-transplant lymphoproliferative disorder after allogenic hematopoietic stem cell transplantation. | 24866354 |
| Post-transplant lymphoproliferative disorder, Lymphoproliferative Disorders | Stem Cell Exhaustion | Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disorder (PTLD) after hematopoietic stem cell transplantation (HSCT) is a rare but life- threatening condition. | 24866354 |
| Extrapulmonary Small Cell Carcinoma, Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | The implications are either in vivo existence of Oct4 positive putative cancer stem cells in ESCC or acquisition of cancer stem cell properties by tumor cells as a response to treatment given, resulting ultimately an uncontrolled cell proliferation and treatment failure. | 24870750 |
| Neoplasms | Stem Cell Exhaustion | It has been hypothesized that Oct4 positive radioresistant stem cells may be responsible for tumor recurrence. | 24870750 |
| Extrapulmonary Small Cell Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Our observations highlighted a possible role of Oct4 in identifying putative cancer stem cells in ESCC pathobiology and response to treatment. | 24870750 |
| Hodgkin Disease | Stem Cell Exhaustion | FDG-PET adapted sequential therapy with brentuximab vedotin and augmented ICE followed by autologous stem cell transplant for relapsed and refractory Hodgkin lymphoma. | 24870873 |
| Stable chronic Graft vs Host Disease, Systemic Scleroderma, Chronic graft-versus-host disease | Stem Cell Exhaustion | Chronic graft-versus-host disease (cGvHD) after hematopoietic stem cell transplantation may have clinical fibrotic features, whose pathogenesis may be similar with systemic sclerosis. | 24873781 |
| Stable chronic Graft vs Host Disease | Stem Cell Exhaustion | Sera from 87 patients including 45 extensive cGvHD and 42 hematopoietic stem cell transplantation patients without cGvHD were retrospectively analyzed for the presence of AT1R-AA using an enzymatic immunoassay. | 24873781 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | A 63-year-old man with a 1-year course of IgA-l multiple myeloma (MM) and a history of autologous stem cell transplantation presented with multiple nontender, nodular violaceous skin lesions that were located predominantly on his trunk. | 24873802 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Differential sensitivity of Glioma stem cells to Aurora kinase A inhibitors: implications for stem cell mitosis and centrosome dynamics. | 24879067 |
| Glioblastoma Multiforme Pathway, Neoplasms, Adult Glioblastoma, Specialty Type - cancer | Stem Cell Exhaustion | Glioma stem-cell-like cells are considered to be responsible for treatment resistance and tumour recurrence following chemo-radiation in glioblastoma patients, but specific targets by which to kill the cancer stem cell population remain elusive. | 24879067 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | In this study we have analysed specific features of glioma stem cell mitosis. | 24879067 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Accordingly, glioma stem cell survival appeared to be strongly dependent on Aurora A activity. | 24879067 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | We found that glioma stem cells appear to be highly prone to undergo aberrant cell division and polyploidization. | 24879067 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Unlike differentiated cells, glioma stem cells responded to moderate Aurora A inhibition with spindle defects, polyploidization and a dramatic increase in cellular senescence, and were selectively sensitive to Aurora A and Plk1 inhibitor treatment. | 24879067 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Our study proposes inhibition of centrosomal kinases as a novel strategy to selectively target glioma stem cells. | 24879067 |
| Malignant Neoplasms, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Abnormal apoptosis is one of the hallmarks of cancers including acute myeloid leukemia (AML), as it plays a pivotal role in precisely maintaining self-renewal, proliferation, and differentiation properties of hematopoietic stem cells (HSCs). | 24879622 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Mobilization-driven postconsolidation therapy in elderly patients with acute myeloid leukemia: feasibility and efficacy of autologous stem cell transplantation versus low-dose gemtuzumab ozogamicin. | 24880020 |
| Postoperative Complications | Stem Cell Exhaustion | This prospective observational trial studied the mobilization of endothelial progenitor cells (EPCs) in response to exercise in association with postoperative complications. | 24880828 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Relapse in acute myeloid leukemia (AML) after chemotherapy reflects the persistence of resistant leukemia stem cells (LSCs). | 24884314 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | We investigated the expression status of AGBL2 and its inhibitor latexin in breast cancer stem cells and its clinical implications in order to lay a foundation for managing breast cancer. | 24884516 |
| Infection | Stem Cell Exhaustion | Mannose-binding lectin gene variants and infections in patients receiving autologous stem cell transplantation. | 24886325 |
| Infection | Stem Cell Exhaustion | Serious infections are common in patients undergoing autologous stem cell transplantation (ASCT) mainly because of the effects of immunosuppression. | 24886325 |
| Specialty Type - cancer, Malignant neoplasm of ovary, Neoplasms | Stem Cell Exhaustion | Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden. | 24886434 |
| Specialty Type - cancer, Malignant neoplasm of ovary, Neoplasms | Stem Cell Exhaustion | We have previously demonstrated that a single short-term treatment of ovarian cancer cells with chemotherapy in vitro resulted in a cancer stem cell (CSC)-like enriched residual population which generated significantly greater tumor burden compared to the tumor burden generated by control untreated cells. | 24886434 |
| Lymphoma, Gastrointestinal mucositis, Multiple Myeloma | Stem Cell Exhaustion | Usefulness and safety of oral cryotherapy in the prevention of oral mucositis after conditioning regimens with high-dose melphalan for autologous stem cell transplantation for lymphoma and myeloma. | 24889275 |
| Morular Metaplasia of the Endometrium, Lymphoid neoplasm, Multiple Myeloma | Stem Cell Exhaustion | This retrospective cohort study analyzes the impact of oral cryotherapy (OC) or room temperature saline rinses on the prevention of OM in patients with multiple myeloma (MM) or lymphoid neoplasias submitted to autologous stem cell transplantation (ASCT) in a single center. | 24889275 |
| Radiation Damage | Stem Cell Exhaustion | Dose-volume histogram (DVH) analysis was performed for specific regions of interest that were considered potential targets of radiation damage, including the thalamus, temporal lobes, nasopharynx, olfactory groove, frontal pole, and periventricular stem cell niche. | 24890354 |
| Peripheral Blood Stem Cells, Lymphoma | Stem Cell Exhaustion | Autologous stem cell transplantation (ASCT) is a potentially curative treatment of lymphoma, but peripheral blood stem cell (PBSC) mobilization fails in some patients. | 24890497 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Two CLL patients that achieved long-term remission following allogeneic hematopoietic stem cell transplantation were monitored for CD8(+) T-cell responses against predicted or confirmed HLA-binding peptides. | 24891321 |
| Chronic diarrhea, Chronic graft-versus-host disease | Stem Cell Exhaustion | In evaluating a patient presenting with chronic diarrhea more than 100 days after BMT, one must consider a serious underlying illness such as chronic GVHD because it is a major cause of morbidity and mortality of allogeneic stem cell transplantation. | 24891601 |
| Liver carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial-mesenchymal transition in hepatocellular carcinoma. | 24892648 |
| Specialty Type - cancer, Hollings Cancer Center | Stem Cell Exhaustion | In this study, we aimed to clarify the mechanism underlying the crosstalk between TAMs and cancer stem cells (CSCs) in HCC. | 24892648 |
| Multiple Myeloma | Stem Cell Exhaustion | Bone marrow plasma cell assessment before peripheral blood stem cell mobilization in patients with multiple myeloma undergoing autologous stem cell transplantation. | 24895639 |
| Liver carcinoma | Stem Cell Exhaustion | Thus, we performed autologous stem cell transplantation for rapid liver regeneration with extensive hepatectomy in hepatocellular cancer patients. | 24895813 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Sirolimus-based graft-versus-host disease prophylaxis promotes the in vivo expansion of regulatory T cells and permits peripheral blood stem cell transplantation from haploidentical donors. | 24897508 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (HSCT) from human leukocyte antigen (HLA) haploidentical family donors is a promising therapeutic option for high-risk hematologic malignancies. | 24897508 |
| Graft-vs-Host Disease, Terminal illness | Stem Cell Exhaustion | Here we explored in 121 patients, mostly with advanced stage diseases, a sirolimus-based, calcineurin-inhibitor-free prophylaxis of graft-versus-host disease (GvHD) to allow the infusion of unmanipulated peripheral blood stem cell (PBSC) grafts from partially HLA-matched family donors (TrRaMM study, Eudract 2007-5477-54). | 24897508 |
| Neoplasms, Gallbladder adenocarcinoma | Stem Cell Exhaustion | This case raises the hypothesis that the so-called "hepatoid adenocarcinoma of the gallbladder" may presently be better understood as a neoplasm derived from hepatobiliary stem/progenitor cells. | 24897774 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | A small subpopulation of cancer stem cells (CSCs) possessing a self-renewing capacity is reported to be responsible for tumor recurrence and therapeutic resistance. | 24898358 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Allogeneic peripheral blood stem cell transplantation using reduced-intensity conditioning in an outpatient setting in ABO-incompatible patients: are survival and graft-versus-host disease different? | 24898453 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease (GVHD) is a major cause of morbimortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 24898453 |
| Graft-vs-Host Disease, Stable chronic Graft vs Host Disease | Stem Cell Exhaustion | Using this type of peripheral blood stem cell transplantation, minor ABO-mismatched allo-HSCT was associated with a higher incidence of aGVHD and cGVHD and with increased survival, albeit with no significance. | 24898453 |
| Thrombocytosis | Stem Cell Exhaustion | Moreover, essential thrombocythaemia patient B cells facilitated megakaryocyte differentiation when co-cultured with CD34+ haematopoietic stem cells. | 24898769 |
| Malignant Neoplasms, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Acute myeloid leukemia (AML), caused by abnormal proliferation and accumulation of hematopoietic progenitor cells, is one of the most common malignancies in adults. | 24901999 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | To elucidate this, CD34(+) stem cell and progenitor cell subpopulations were isolated by fluorescence-activated cell sorting (FACS), and their content of residual Philadelphia positive (Ph(+) ) cells was evaluated in 17 CML patients (major molecular response, n = 6; 4-log reduction in BCR-ABL1 expression (MR(4) ), n = 11) using both sensitive qPCR and interphase fluorescence in situ hybridization (iFISH). | 24903628 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | This approach demonstrates a clinically applicable manner of assessing residual disease at the stem cell level in CML patients in MR(4) , and may enable early and safe identification of candidates for tyrosine kinase inhibitor withdrawal. | 24903628 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Cell sorting enables interphase fluorescence in situ hybridization detection of low BCR-ABL1 producing stem cells in chronic myeloid leukaemia patients beyond deep molecular remission. | 24903628 |
| Acute GVH disease | Stem Cell Exhaustion | [The impact of donor naive and memory T cell subsets on patient outcome following allogeneic stem cell transplantation: relationship between infused donor CD4+/CCR7+ T cell subsets and acute graft-versus-host disease]. | 24906571 |
| Specialty Type - cancer | Stem Cell Exhaustion | The most upregulated genes included epithelial cell adhesion molecule (EpCAM), a biomarker of cancer stem cells (CSC). | 24909871 |
| leukemia, Aplastic Anemia, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Outcome of allogeneic stem cell transplantation for patients transformed to myelodysplastic syndrome or leukemia from severe aplastic anemia: a report from the MDS Subcommittee of the Chronic Malignancies Working Party and the Severe Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation. | 24910382 |
| PAFAH1B1 wt Allele, Aplastic Anemia, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | One hundred and forty patients who had undergone hematopoietic stem cell transplantation (HSCT) for myelodysplastic syndrome (MDS) or acute myelogenous leukemia (AML) transformation after treatment of severe aplastic anemia (SAA) were identified in the European Group for Blood and Marrow Transplantation (EBMT) database. | 24910382 |
| Malignant neoplasm of stomach, Specialty Type - cancer | Stem Cell Exhaustion | To evaluate the frequency of cancer stem cell marker CD44 combined CD324 expression in gastric cancer specimens and association of the expression with survival of gastric cancer patients. | 24910454 |
| Hematologic Neoplasms | Stem Cell Exhaustion | A biosimilar G-CSF (Zarzio((r))) demonstrated similar efficacy and safety as the reference originator G-CSF (Neupogen((r))) in hematopoietic stem cell mobilization in patients with haematological malignancies. | 24911076 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Mesenchymal stem cells (MSCs) are a promising cell type for the repair of damaged cartilage in osteoarthritis (OA). | 24911520 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Stem cell transplantations and donor lymphocyte infusions are promising immunotherapies to cure acute myeloid leukemia (AML). | 24911794 |
| Fibrosis Assessment | Stem Cell Exhaustion | Improvement in Spinal Cord Injury-Induced Bladder Fibrosis Using Mesenchymal Stem Cell Transplantation Into the Bladder Wall. | 24912020 |
| Stanford Cancer Institute, Spinal Cord Injuries, Bladder dysfunction | Stem Cell Exhaustion | Experiments on spinal cord injury (SCI) have largely focused on the transplantation of stem cells into injured spinal cords for motor recovery while neglecting to investigate bladder dysfunction. | 24912020 |
| Stanford Cancer Institute | Stem Cell Exhaustion | The present study was performed to investigate the effect of B10 human mesenchymal stem cells (hMSCs) directly transplanted into the bladder wall of SCI rats and to determine whether they are capable of inhibiting collagen deposition and improving cystometric parameters in SCI rats. | 24912020 |
| Chronic myeloproliferative disorder, Primary Myelofibrosis, Leukemia, Myelocytic, Acute, PMF Regimen | Stem Cell Exhaustion | In studies designed to define neoplastic stem cells of primary myelofibrosis (PMF), a myeloproliferative neoplasm characterized by profound disruption of the hematopoietic microenvironment, we observed a high frequency of acute myeloid leukemia (AML) in NSG mice. | 24912157 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Extracorporeal photopheresis (ECP) constitutes a promising treatment for patients with steroid-refractory acute graft-versus-host disease (aGvHD) after allogeneic stem cell transplantation and for patients with graft rejection after solid organ transplantation (SOT). | 24913503 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Allogeneic stem cell transplant in patients with chronic lymphocytic leukemia with 17p deletion: consult-transplant versus consult- no-transplant analysis. | 24913509 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Allogeneic stem cell transplant (alloSCT) can overcome the adverse prognosis of chronic lymphocytic leukemia with 17p deletion (17p- CLL). | 24913509 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Prediction of non-relapse mortality in recipients of reduced intensity conditioning allogeneic stem cell transplantation with AML in first complete remission. | 24913728 |
| Tears body substance | Stem Cell Exhaustion | Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study. | 24913770 |
| Renal dysfunction | Stem Cell Exhaustion | The purpose of this study was to retrospectively evaluate the incidence of delayed renal dysfunction after total body irradiation (TBI) in long-term survivors of TBI/hematopoietic stem cell transplantation (HSCT). | 24914103 |
| Sepsis | Stem Cell Exhaustion | His elder brother exhibited a similar clinical presentation and died from sepsis after hematopoietic stem cell transplantation. | 24914498 |
| herpesvirus 3, human | Stem Cell Exhaustion | One-year prophylaxis with acyclovir has been shown to effectively prevent varicella-zoster virus (VZV) reactivation after allogeneic hematopoietic stem cell transplantation (HSCT) in a cohort that underwent transplantation in the beginning of the 2000s. | 24914821 |
| melanoma | Stem Cell Exhaustion | CTCs were captured by targeting the melanoma associated markers MCSP and MCAM as well as the melanoma stem cell markers ABCB5 and CD271. | 24915896 |
| Angioimmunoblastic Lymphadenopathy | Stem Cell Exhaustion | Cyclosporine treatment of angioimmunoblastic T-cell lymphoma relapsed after an autologous hematopoietic stem cell transplant. | 24918480 |
| Autoimmune hemolytic anemia, Angioimmunoblastic Lymphadenopathy | Stem Cell Exhaustion | Here, we report a case of 53-year-old woman with angioimmunoblastic T-cell lymphoma who underwent high-dose chemotherapy with an autologous hematopoietic stem cell transplant after several cycles of chemotherapy, but soon relapsed with severe autoimmune hemolytic anemia. | 24918480 |
| Angioimmunoblastic Lymphadenopathy | Stem Cell Exhaustion | Thus, we conclude that cyclosporine has an effect in relapsed angioimmunoblastic T-cell lymphoma after an autologous hematopoietic stem cell transplant. | 24918480 |
| Cerebral Infarction | Stem Cell Exhaustion | Long-term MRI cell tracking after intraventricular delivery in a patient with global cerebral ischemia and prospects for magnetic navigation of stem cells within the CSF. | 24919061 |
| Cerebral Infarction | Stem Cell Exhaustion | After approval by our Institutional Review Board, an 18-month-old patient, diagnosed as being in a vegetative state due to global cerebral ischemia, underwent cell transplantation to the frontal horn of the lateral ventricle, with umbilical cord blood-derived stem cells labeled with superparamagnetic iron oxide (SPIO) contrast agent. | 24919061 |
| Colorectal Carcinoma, Specialty Type - cancer, Cytogenetic Complete Response | Stem Cell Exhaustion | CD133 and CD44 are putative cancer stem cell (CSC) markers in colorectal cancer (CRC). | 24921913 |
| Specialty Type - cancer, Cytogenetic Complete Response | Stem Cell Exhaustion | Cancer stem cell marker expression was examined in both xenografts and a complementary DNA library compiled from 167 CRC patient samples. | 24921913 |
| Bulbo-Spinal Atrophy, X-Linked | Stem Cell Exhaustion | Stem cell-derived motor neurons from spinal and bulbar muscular atrophy patients. | 24925468 |
| Bulbo-Spinal Atrophy, X-Linked | Stem Cell Exhaustion | Induced pluripotent stem cells from spinal and bulbar muscular atrophy patients provide a useful model for understanding the disease mechanism and designing effective therapy. | 24925468 |
| Bulbo-Spinal Atrophy, X-Linked | Stem Cell Exhaustion | SBMA stem cells present new insights into the disease, and the observations of reduced androgen receptor levels, repeat instability, and reduced HDAC6 provide avenues for further investigation of the disease mechanism and development of effective therapy. | 24925468 |
| Multiple Myeloma | Stem Cell Exhaustion | Pharmacoeconomic impact of up-front use of plerixafor for autologous stem cell mobilization in patients with multiple myeloma. | 24927717 |
| Bone neoplasms | Stem Cell Exhaustion | Age-specific bone tumour incidence rates are governed by stem cell exhaustion influencing the supply and demand of progenitor cells. | 24927913 |
| Neoplasms | Stem Cell Exhaustion | To fill this gap, I hypothesize that neoplasms preferentially arise when stem cell exhaustion creates a short supply of progenitor cells at ages of high proliferative demand. | 24927913 |
| Osteosarcoma, Cartilaginous exostosis | Stem Cell Exhaustion | Results show that progenitor cell demand-to-supply ratios are a good risk indicator, exhibiting similar trends to the unimodal and bimodal age distributions of osteochondroma and osteosarcoma, respectively. | 24927913 |
| Multiple Myeloma | Stem Cell Exhaustion | Combination of bortezomib, thalidomide, and dexamethasone (VTD) as a consolidation therapy after autologous stem cell transplantation for symptomatic multiple myeloma in Japanese patients. | 24928523 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Consolidation therapy for patients with multiple myeloma (MM) has been widely adopted to improve treatment response following autologous stem cell transplantation. | 24928523 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Fractalkine levels are elevated early after PCI-treated ST-elevation myocardial infarction; no influence of autologous bone marrow derived stem cell injection. | 24930044 |
| Acute myocardial infarction | Stem Cell Exhaustion | There is limited knowledge of fractalkine levels during acute myocardial infarction (AMI) and stem cell treatment. | 24930044 |
| Angina Pectoris, Acute myocardial infarction | Stem Cell Exhaustion | We examined fractalkine levels at different time points by enzyme-linked immunosorbent assay (ELISA) in 20 patients with AMI, and 10 patients with stable angina pectoris (AP) undergoing percutaneous coronary intervention (PCI), and in 100 patients included in the randomized Autologous Stem-Cell Transplantation in Acute Myocardial Infarction (ASTAMI) trial. | 24930044 |
| Infectious Lung Disorder | Stem Cell Exhaustion | Pulmonary Nocardia nova infection after allogeneic hematopoietic stem cell transplantation. | 24930664 |
| Graft-vs-Host Disease, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We herein report the case of a 68-year-old man with a history of allogeneic hematopoietic stem cell transplantation for acute myelocytic leukemia in whom graft-versus-host disease (GVHD) developed in the gastrointestinal tract and liver five months after transplantation. | 24930664 |
| Wiskott-Aldrich Syndrome, Lymphoma, Non-Hodgkin | Stem Cell Exhaustion | Successful treatment of non-Hodgkin's lymphoma using R-CHOP in a patient with Wiskott-Aldrich syndrome followed by a reduced-intensity stem cell transplant. | 24930759 |
| Bacteremia | Stem Cell Exhaustion | Impact of peri-transplant vancomycin and fluoroquinolone administration on rates of bacteremia in allogeneic hematopoietic stem cell transplant (HSCT) recipients: a 12-year single institution study. | 24931578 |
| Malignant melanoma of conjunctiva, Trauma | Stem Cell Exhaustion | Four consecutive patients with unilateral partial (2 eyes) and total (2 eyes) limbal stem cell deficiency secondary to ocular surface burns (2 eyes), trauma (1 eye) and conjunctival melanoma treatment (1 eye) underwent modified simple limbal epithelial transplantation at Bascom Palmer Eye Institute. | 24932987 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is recommended for patients with high-risk acute myeloid leukemia (AML). | 24933658 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | Hypermethylation of DDAH2 promoter contributes to the dysfunction of endothelial progenitor cells in coronary artery disease patients. | 24934151 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | Circulating endothelial progenitor cells (EPCs) may be a biomarker for vascular function and cardiovascular risk in patients with coronary artery disease (CAD). | 24934151 |
| Prediabetes syndrome, Diabetes, Acute myocardial infarction | Stem Cell Exhaustion | Reduced levels of circulating endothelial progenitor cells in acute myocardial infarction patients with diabetes or pre-diabetes: accompanying the glycemic continuum. | 24934236 |
| Carcinogenesis | Stem Cell Exhaustion | Recently, the SRY-related transcription factor SOX2 has been widely reported to be involved in multiple pathophysiological diseases, including maintenance of stem cell characteristics and carcinogenesis. | 24937695 |
| Mycoses | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplant patients are at risk of invasive fungal infections and prophylaxis with azole agents is common practice. | 24938293 |
| Cessation of life | Stem Cell Exhaustion | The differences between groups in relapse incidence, non-relapse mortality, and death rate during induction were not statistically significant, although the older-adolescents trended towards a higher frequency of having stem-cell transplantation during the first remission. | 24938380 |
| Hematologic Neoplasms, Metabolic Syndrome X, Mitral Valve Stenosis | Stem Cell Exhaustion | The relationship between treatment for hematologic malignancies and risk of developing metabolic syndrome (MS) is controversial; in addition, metabolic changes following hematopoietic stem cell transplantation (HSCT) is an area of growing interest. | 24940820 |
| Specialty Type - cancer | Stem Cell Exhaustion | Peripheral blood stem cell (PBSC) rescue following myeloablative therapy is a mainstay of cancer therapy. | 24941931 |
| Autoimmune state | Stem Cell Exhaustion | Does Teno Torque Virus Induce Autoimmunity After Hematopoietic Stem Cell Transplantation? | 24942030 |
| Dermatitis, Atopic, Leukemia, Myelocytic, Acute, Autoimmune Chronic Hepatitis | Stem Cell Exhaustion | We report here a case of an 11-month-old infant affected by acute myeloid leukemia who underwent hematopoietic stem cell transplantation, and after 6 months had autoimmune hepatitis and atopic dermatitis. | 24942030 |
| Muscular Dystrophy | Stem Cell Exhaustion | One of the questions to be addressed is whether stem cells from distinct sources have comparable clinical effects when injected in murine or canine muscular dystrophy animal models. | 24943487 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Mycophenolate mofetil use after unrelated hematopoietic stem cell transplantation for prophylaxis and treatment of graft-vs.-host disease in adult patients in Japan. | 24943923 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Our previous study of 301 patients who received hematopoietic stem cell transplantation (HSCT) from related donors demonstrated the efficacy of mycophenolate mofetil (MMF) for prophylaxis and treatment of graft-vs.-host disease (GVHD). | 24943923 |
| Lymphoma | Stem Cell Exhaustion | ICE/R-ICE (ifosfamide, carboplatin, and etoposide without or with rituximab) chemotherapy followed by autologous stem cell transplantation is an established regimen in refractory/relapsed lymphoma. | 24944079 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | Upfront autologous stem-cell transplantation with melphalan, cyclophosphamide, etoposide, and dexamethasone (LEED) in patients with newly diagnosed primary central nervous system lymphoma. | 24947495 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | We report 13 consecutive patients with PCNSL for whom upfront melphalan, cyclophosphamide, etoposide, and dexamethasone (known as LEED) followed by autologous stem-cell transplantation (ASCT) was planned at the Anjo Kosei Hospital. | 24947495 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Compared with growth factor (G) alone, the combination of G with plerixafor (G + P) increases peripheral blood CD34+ count (PB-CD34+) and improves CD34+ collection yield (yCD34+) in multiple myeloma and lymphoma patients undergoing autologous hematopoietic progenitor cell (AHPC) mobilization. | 24947954 |
| Bone marrow hypocellularity, Aneuploidy | Stem Cell Exhaustion | As telomeres protect chromosomes from instability, it is highly plausible that this genetic lesion was responsible for the patient's hematological manifestations, including marrow failure and aneuploidy in the hematopoietic stem cell compartment. | 24948335 |
| Multiple Myeloma | Stem Cell Exhaustion | High-dose chemotherapy plus autologous stem-cell transplantation as consolidation therapy in patients with relapsed multiple myeloma after previous autologous stem-cell transplantation (NCRI Myeloma X Relapse [Intensive trial]): a randomised, open-label, phase 3 trial. | 24948586 |
| Relapse multiple myeloma | Stem Cell Exhaustion | Relapsed multiple myeloma has no standard treatment, and the role of autologous stem-cell transplantation (ASCT) has not been fully defined. | 24948586 |
| Colon Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | CD133/CD166/Ki-67 triple immunofluorescence assessment for putative cancer stem cells in colon carcinoma. | 24949608 |
| Malignant tumor of colon, Secondary Neoplasm | Stem Cell Exhaustion | The existence of drug-resistant colon cancer stem cells is thought to be one of the most important reasons behind treatment failure in colon cancer, their existence putatively leading to metastasis and recurrences. | 24949608 |
| Toxic effect | Stem Cell Exhaustion | The CloB2A2 regimen prior to allogeneic stem cell transplantation is feasible, allowing for full engraftment and low toxicity. | 24951467 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | XIAP inhibitors induce differentiation and impair clonogenic capacity of acute myeloid leukemia stem cells. | 24952669 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | XIAP inhibition differentially impaired cell viability of the most primitive AML blasts and reduced clonogenic capacity of AML cells, sparing healthy mature blood and hematopoietic stem cells. | 24952669 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Cytogenetics, donor type, and use of hypomethylating agents in myelodysplastic syndrome with allogeneic stem cell transplantation. | 24953017 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | We investigated the impact of patient and disease characteristics, including cytogenetics, previous therapy, and depth of response, on the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) for patients with myelodysplastic syndrome (MDS). | 24953017 |
| Hemorrhagic cystitis | Stem Cell Exhaustion | Fibrin glue therapy for severe hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation. | 24953019 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplantation (ASCT) is a curative option alternative to allogeneic transplantation for patients with acute myeloid leukemia (AML). | 24954546 |
| Bronchiolitis Obliterans | Stem Cell Exhaustion | Parametric response mapping as an indicator of bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation. | 24954547 |
| Bone Diseases, Multiple Myeloma, Spinal Fractures | Stem Cell Exhaustion | In this study, we evaluated four SNPs rs11099592, rs4364254, rs4693608 and rs6535455 in the HSPE gene in 348 newly diagnosed multiple myeloma patients with focus on bone morbidity (lytic bone disease and vertebral fractures) and outcome after high-dose chemotherapy with stem cell support (HDT). | 24954766 |
| Fracture | Stem Cell Exhaustion | Bone marrow stem cells added to a hydroxyapatite scaffold result in better outcomes after surgical treatment of intertrochanteric hip fractures. | 24955356 |
| Fracture | Stem Cell Exhaustion | The authors hypothesized that adding an autologous bone marrow stem cells concentrate (ABMC) to a hydroxyapatite scaffold and placing it in the fracture site would improve the outcome after surgical fixation of intertrochanteric hip fractures. | 24955356 |
| Multiple Myeloma | Stem Cell Exhaustion | There has been significant improvement in the survival of multiple myeloma patients over the past decade as a result of incorporating autologous stem cell transplantation (ASCT) and novel agents into treatment regimens. | 24957143 |
| Macrodontia of permanent maxillary central incisor | Stem Cell Exhaustion | Characterization of pulp and follicle stem cells from impacted supernumerary maxillary incisors. | 24960375 |
| Macrodontia of permanent maxillary central incisor | Stem Cell Exhaustion | The purpose of this study was to characterize dental pulp and dental follicle stem/progenitor cells (DPSCs and DFSCs) from the same impacted supernumerary maxillary incisors (ISMIs). | 24960375 |
| Primary Myelofibrosis | Stem Cell Exhaustion | MPD-RC 101 prospective study of reduced-intensity allogeneic hematopoietic stem cell transplantation in patients with myelofibrosis. | 24963042 |
| Thrombocytosis, Polycythemia Vera, Myeloproliferative disease, Primary Myelofibrosis | Stem Cell Exhaustion | From 2007 to 2011, 66 patients with primary myelofibrosis or myelofibrosis (MF) preceded by essential thrombocythemia or polycythemia vera were enrolled into a prospective phase 2 clinical trial of reduced-intensity allogeneic hematopoietic stem cell transplantation (AHSCT), Myeloproliferative Disorder Research Consortium 101 trial. | 24963042 |
| Malignant neoplasm of stomach, Neoplasms | Stem Cell Exhaustion | Stem cell-like circulating tumor cells indicate poor prognosis in gastric cancer. | 24963492 |
| Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Circulating tumor cells (CTCs), which have stem cell-like characteristics, might play a crucial role in cancer metastasis. | 24963492 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | CD44 has been identified as gastric cancer (GC) stem cell (CSC) marker. | 24963492 |
| Restenosis | Stem Cell Exhaustion | The impact of endothelial progenitor cells on restenosis after percutaneous angioplasty of hemodialysis vascular access. | 24964143 |
| Restenosis | Stem Cell Exhaustion | We prospectively investigate the relation between baseline circulating endothelial progenitor cells and the subsequent development of restenosis after angioplasty of hemodialysis vascular access. | 24964143 |
| Toxic effect | Stem Cell Exhaustion | Dimethyl sulfoxide (DMSO) is essential for the preservation of liquid nitrogen-frozen stem cells, but is associated with toxicity in the transplant recipient. | 24964911 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | In this prospective noninterventional study, we describe the use of DMSO in 64 European Blood and Marrow Transplant Group centers undertaking autologous transplantation on patients with myeloma and lymphoma and analyze side effects after return of DMSO-preserved stem cells. | 24964911 |
| Multiple Myeloma | Stem Cell Exhaustion | Mesenchymal stem cell contact promotes CCN1 splicing and transcription in myeloma cells. | 24965524 |
| Multiple Myeloma | Stem Cell Exhaustion | To elucidate the role of CCN1 in the crosstalk between stromal cells and myeloma cells, we performed co-culture experiments with primary mesenchymal stem cells (MSC) and the interleukin-6 (IL-6)-dependent myeloma cell line INA-6. | 24965524 |
| Acute lymphocytic leukemia, BCR gene | Stem Cell Exhaustion | Even in the tyrosine kinase inhibitor era, allogeneic hematopoietic stem cell transplantation (HSCT) is regarded as standard care for adult Philadelphia (Ph) positive acute lymphoblastic leukemia (ALL). | 24965535 |
| Amyotrophic Lateral Sclerosis | Stem Cell Exhaustion | Biological markers of mesenchymal stromal cells as predictors of response to autologous stem cell transplantation in patients with amyotrophic lateral sclerosis: an investigator-initiated trial and in vivo study. | 24966156 |
| Degenerative polyarthritis | Stem Cell Exhaustion | In summary, DCC is up-regulated in CD166-positive chondrogenic progenitor cells in OA and induces down-regulation of CREB. | 24966904 |
| Cartilage damage | Stem Cell Exhaustion | These findings indicate that migration of CD166 positive progenitor cells to sites of cartilage damage may be directed by regulation of DCC signaling. | 24966904 |
| Cervical Squamous Cell Carcinoma | Stem Cell Exhaustion | Embryonic stem cell markers Sox-2 and OCT4 expression and their correlation with WNT signal pathway in cervical squamous cell carcinoma. | 24966958 |
| Malignant Neoplasms | Stem Cell Exhaustion | Both the expression of embryonic stem cells (ESCs) markers (Sox2, Oct4) and the Wnt signal pathway (b-catenin) are crucial for progression of various human malignancies. | 24966958 |
| Corneal Endothelial Cell Loss | Stem Cell Exhaustion | Circulating endothelial progenitor cells (EPCs) play an important role in post-injury regeneration of vasculature, whereas endothelial cells (ECs) reflect endothelial damage. | 24968203 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Cardiomyogenic differentiation potential of human endothelial progenitor cells isolated from patients with myocardial infarction. | 24969968 |
| Myocardial Ischemia, Peripheral Arterial Diseases | Stem Cell Exhaustion | Endothelial progenitor cells (EPCs) are known to play a beneficial role by promoting postnatal vasculogenesis in pathological events, such as ischemic heart disease and peripheral artery disease. | 24969968 |
| Pheochromocytoma | Stem Cell Exhaustion | Dissecting the origin of inducible brown fat in adult humans through a novel adipose stem cell model from adipose tissue surrounding pheochromocytoma. | 24971662 |
| Clostridium difficile colitis | Stem Cell Exhaustion | Clostridium difficile infection after allogeneic hematopoietic stem cell transplant: strain diversity and outcomes associated with NAP1/027. | 24973628 |
| Clostridium difficile colitis, Central Diabetes Insipidus | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (HSCT) recipients are at high risk for developing Clostridium difficile infection (CDI). | 24973628 |
| Central Diabetes Insipidus, Communicable Diseases | Stem Cell Exhaustion | Early CDI was defined as infection occurring from day -10 to day +40 from stem cell infusion. | 24973628 |
| Neoplasms | Stem Cell Exhaustion | Reactive oxygen species in normal and tumor stem cells. | 24974178 |
| Neoplasms | Stem Cell Exhaustion | In addition, the implications of the aberrant production of ROS by tumor stem cells for tumor progression and treatment are also discussed. | 24974178 |
| Neoplasms, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | AML cells from putative leukaemia stem cell subsets, including CD34+38- and CD34+38+ fractions, were equivalently affected by dual PIM/Akt inhibition when compared with bulk tumour cells. | 24975213 |
| Acute myocardial infarction | Stem Cell Exhaustion | The beneficial effects of intracoronary autologous bone marrow stem cell transfer as an adjunct to percutaneous coronary intervention in patients with acute myocardial infarction. | 24975729 |
| Acute myocardial infarction | Stem Cell Exhaustion | The efficacy of post-percutaneous coronary intervention (PCI) intracoronary injection with bone marrow mesenchymal stem cells (BMSCs) in patients with acute myocardial infarction (AMI) remains controversial. | 24975729 |
| Peripheral Stem Cell Transplantation, Specialty Type - cancer | Stem Cell Exhaustion | The aim of this study was to assess the agreement between detected changes in body composition determined by bioimpedance spectroscopy (BIS) and air-displacement plethysmography (ADP) among patients with cancer undergoing peripheral blood stem cell transplantation (PBSCT); and to assess the agreement of absolute values of BIS with ADP and dual energy x-ray (DXA). | 24976421 |
| Autoimmune cytopenia | Stem Cell Exhaustion | Autoimmune cytopenias (AC) after allogeneic hematopoietic stem cell transplantation (HSCT) are associated with a dismal prognosis. | 24976527 |
| Embryonal Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | MyD88 expression was down-regulated in differentiated embryonal carcinoma (NTera2) cells, supporting the MyD88+ cancer stem cell hypothesis. | 24977712 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | Ex vivo manipulation of ovarian cancer stem cell (CSC) differentiation can decrease MyD88 expression, providing a potentially valuable CSC model for ovarian cancer. | 24977712 |
| melanoma, Stem Cell Factor | Stem Cell Exhaustion | Comparing the sera of pretreated patients against the control samples, the cytokines fibroblast growth factor 10 (FGF-10/keratinocyte growth factor-2 (KGF-2), chemokine (C-X-C motif) ligand 11 interferon inducible T cell alpha chemokine (I-TAC)/chemokine [C-X-C motif] ligand 11 (CXCL11), oncostatin M (OSM), osteoactivin/glycoprotein nonmetastatic melanoma protein B, and stem cell factor (SCF) were found significantly overexpressed. | 24979617 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Acute graft-versus-host-disease (aGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (HSCT). | 24979731 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Chronic graft versus host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation, which contributes to the morbidity and mortality of transplant patients. | 24980629 |
| Polymyositis, Traumatic AND/OR non-traumatic injury, Skeletal muscle structure, Chronic graft-versus-host disease | Stem Cell Exhaustion | A polymyositis pattern of injury is a rare manifestation of chronic GVHD in skeletal muscle after hematopoietic stem cell transplantation. | 24980629 |
| Cholangiocarcinoma | Stem Cell Exhaustion | Successfully-treated advanced bile duct cancer of donor origin after hematopoietic stem cell transplantation by pancreaticoduodenectomy: a case report. | 24982403 |
| Neoplasm Metastasis | Stem Cell Exhaustion | Secondary malignancies are one of the late complications observed in long-term survivors of allogeneic hematopoietic stem cell transplantation (HSCT). | 24982403 |
| Lymphoma | Stem Cell Exhaustion | Considering this residuum and the aggressive subtype of lymphoma he was referred for an autologous hemopoietic stem cell transplantation (AHSCT). | 24985032 |
| Urinary Stress Incontinence | Stem Cell Exhaustion | Autologous adipose stem cells in treatment of female stress urinary incontinence: results of a pilot study. | 24985079 |
| Sui Chinese, Urinary Stress Incontinence | Stem Cell Exhaustion | The purpose of our study was to find out whether transurethral injections of autologous adipose stem cells (ASCs) are an effective and a safe treatment for female stress urinary incontinence (SUI). | 24985079 |
| B-Cell Lymphomas, Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | To assess the efficacy of dose-intensive immunochemotherapy with or without autologous hematopoietic stem cell transplantation (ASCT) for newly diagnosed young patients with medium/high risk diffuse large B-cell lymphoma (DLBCL). | 24985182 |
| Toxic effect | Stem Cell Exhaustion | In hematopoietic stem cell transplantation (HSCT), patients receive individualized treatment planning in conditioning regimens to prevent unwarranted toxicities while maximizing desired outcomes. | 24986792 |
| Prostate carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Expression of androgen and estrogen signaling components and stem cell markers to predict cancer progression and cancer-specific survival in patients with metastatic prostate cancer. | 24987058 |
| Prostate carcinoma | Stem Cell Exhaustion | Genes of androgen and estrogen signaling cells and stem cell-like cells play crucial roles in prostate cancer. | 24987058 |
| Acute leukemia | Stem Cell Exhaustion | Liposomal daunorubicin, fludarabine, and cytarabine (FLAD) as bridge therapy to stem cell transplant in relapsed and refractory acute leukemia. | 24989345 |
| Acute leukemia | Stem Cell Exhaustion | We report the outcome of 79 patients with relapsed-refractory acute leukemia treated with fludarabine, cytarabine, and liposomal daunorubicin (FLAD regimen) followed by hematopoietic stem cell transplantation (HSCT), when clinically indicated, between May 2000 and January 2013. | 24989345 |
| Rheumatoid Arthritis | Stem Cell Exhaustion | To identify factors influencing endothelial progenitor cell (EPC) counts in patients with rheumatoid arthritis (RA). | 24991663 |
| Rheumatoid Arthritis, Endothelial dysfunction | Stem Cell Exhaustion | Bone erosion is associated with reduction of circulating endothelial progenitor cells and endothelial dysfunction in rheumatoid arthritis. | 24991663 |
| Rubella, Mumps | Stem Cell Exhaustion | Evaluation of the immune status against measles, mumps, and rubella in adult allogeneic hematopoietic stem cell transplantation recipients. | 24992512 |
| Mumps | Stem Cell Exhaustion | Previous studies have shown that most patients lose immunity to measles, mumps, and rubella (MMR) during long-term follow-up after allogeneic hematopoietic stem cell transplantation (HSCT), and immunizations against them have been investigated. | 24992512 |
| Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE | Stem Cell Exhaustion | Effect of aliskiren on circulating endothelial progenitor cells and vascular function in patients with type 2 diabetes and essential hypertension. | 24994608 |
| Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE | Stem Cell Exhaustion | The aim of this study was to investigate the effects of aliskiren on vascular function and endothelial progenitor cells (EPCs) in patients with type 2 diabetes and essential hypertension. | 24994608 |
| Hematologic Neoplasms, Transfusion hemosiderosis | Stem Cell Exhaustion | This is the first prospective study of deferasirox in adult allogeneic hematopoietic stem cell transplant recipients with transfusional iron overload in hematologic malignancies. | 24997153 |
| Gastrointestinal Stromal Tumors | Stem Cell Exhaustion | Gastric gastrointestinal stromal tumors (GISTs) usually contain the mast/stem cell growth factor receptor Kit gene (KIT) or platelet-derived growth factor receptor A (PDGFRA) mutations that can be targeted by, or mediate resistance to, imatinib. | 24997326 |
| Aortic Aneurysm, Abdominal | Stem Cell Exhaustion | Proinflammatory role of stem cells in abdominal aortic aneurysms. | 24997808 |
| Aneurysmal | Stem Cell Exhaustion | We sought to describe the presence of stem cells in human AAA tissue and also investigated the differentiation of stem cells within the aneurysmal aorta. | 24997808 |
| Aneurysm | Stem Cell Exhaustion | These finding suggest an inflammatory/immune role of stem cells during AAA pathogenesis and raise the possibility of localized replenishment therapy within the aneurysm wall. | 24997808 |
| Dyskeratosis Congenita, Hemorrhagic colitis | Stem Cell Exhaustion | Diffuse hemorrhagic colitis in a patient with dyskeratosis congenita after nonmyeloablative allogeneic hematopoietic stem cell transplantation. | 25000468 |
| Bone marrow hypocellularity | Stem Cell Exhaustion | Bone marrow failure in DC can only be cured by allogeneic hematopoietic stem cell transplantation (HSCT). | 25000468 |
| nervous system disorder | Stem Cell Exhaustion | Over the last decade, human cell transplantation and neural stem cell trials have examined the feasibility and safety of these potential therapies for treatment of a variety of neurological disorders. | 25002238 |
| Vasculitis, CTCAE, Autoimmune Diseases | Stem Cell Exhaustion | ANCA-positive vasculitis as a secondary autoimmune disease after autologous stem cell transplantation for systemic sclerosis: a case report. | 25005330 |
| Autoimmune Diseases, Systemic Scleroderma, Up, Sample Size Calculation | Stem Cell Exhaustion | Autologous stem cell transplantation (SCT) is increasingly used to treat autoimmune diseases (AD), in particular systemic sclerosis (SSc). | 25005330 |
| Autoimmune Diseases | Stem Cell Exhaustion | Secondary autoimmune diseases are a known complication after autologous stem cell transplantations for any cause. | 25005330 |
| Vasculitis, CTCAE, Autoimmune Diseases | Stem Cell Exhaustion | We provide the first report of a patient who developed a p-ANCA-associated vasculitis after autologous stem cell transplantation for an autoimmune disease, namely systemic sclerosis. | 25005330 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | CTC presence was evaluated with real-time reverse transcription polymerase chain reaction assay (qPCR) based on the expression of three tumor genetic markers: carcinoembryonic antigen (CEA), cytokeratin 20 (CK20), and/or cancer stem cells marker CD133 (CEA/CK20/CD133). | 25006584 |
| Senile cardiac amyloidosis | Stem Cell Exhaustion | Median OPN plasma level were associated with number of organs involved, renal function, eligibility for high-dose melphalan chemotherapy and autologous stem cell transplantation, and severity of cardiac amyloidosis. | 25007036 |
| Communicable Diseases | Stem Cell Exhaustion | [Usefulness of wide-range microbiological diagnostics proceedings in case of simultaneous infection with four herpesviruses after allogeneic haematopoietic stem cell transplantation--a case report]. | 25007510 |
| Immunocompromised Host | Stem Cell Exhaustion | A case of fatal post-transplant reactivation with four herpesviruses in 49-year-old immunocompromised male with MDS-RAEB2, subjected to allogeneic haematopoietic stem cell transplantation was described. | 25007510 |
| leukemia | Stem Cell Exhaustion | Leukemia is a type of malignant hematopoietic tumor in hematopoietic stem cells. | 25011265 |
| Prostate carcinoma, Ionizing radiation | Stem Cell Exhaustion | In this study, exposure of four metastasis-derived human prostate cancer cell lines (DU145, PC-3, LNCaP and 22RV1) to clinically relevant daily fractions of ionizing radiation (35 doses of 2 Gy) resulted in generation of two radiation-surviving populations: adherent senescent-like cells expressing common senescence-associated markers and non-adherent anoikis-resistant stem cell-like cells with active Notch signaling and expression of stem cell markers CD133, Oct-4, Sox2 and Nanog. | 25012501 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | In contrast to TKIs, interferon (IFN) is directly toxic to CML progenitor cells, and myeloid growth factors such as GM-CSF may enhance IFN's cytotoxicity. | 25012565 |
| Hemopoietic stem cell transplant | Stem Cell Exhaustion | From March 2010 to September 2010, all patients admitted to our unit for chemotherapy for acute leukemia or hematopoietic stem cell transplantation received optimized PSZ prophylaxis 200 mg four times daily with cola soda. | 25012993 |
| Specialty Type - cancer, Nasopharyngeal carcinoma | Stem Cell Exhaustion | E3-ligase Skp2 predicts poor prognosis and maintains cancer stem cell pool in nasopharyngeal carcinoma. | 25015320 |
| Specialty Type - cancer | Stem Cell Exhaustion | Our study not only interprets the predictive role of Skp2 in the poor prognosis of NPC patients, but also reveals that Skp2 regulates the NPC cancer stem cell maintenance, which shed lights on the target therapy and early diagnosis of NPC in clinical application. | 25015320 |
| Neoplasms, Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | Moreover, the presence in these tumors of cancer stem cells, which are characterized by CD133 expression, has been associated with chemoresistance, radioresistance, metastasis, and local recurrence. | 25015560 |
| Allogeneic Hematopoietic Stem Cell Transplantation, Central Nervous System, Acute lymphocytic leukemia | Stem Cell Exhaustion | Central nervous system relapse in adults with acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation. | 25017763 |
| Acute lymphocytic leukemia, Central Nervous System, BCR gene | Stem Cell Exhaustion | Central nervous system (CNS) relapse after allogeneic hematopoietic stem cell transplantation (HSCT) confers a poor prognosis in adult patients with acute lymphoblastic leukemia (ALL). | 25017763 |
| Graft-vs-Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Chronic graft-versus-host disease (GVHD) induces significant morbidity and mortality after allogeneic hematopoietic stem cell transplantation. | 25017765 |
| Aneuploidy | Stem Cell Exhaustion | Asymmetric aneuploidy in mesenchymal stromal cells detected by in situ karyotyping and fluorescence in situ hybridization: suggestions for reference values for stem cells. | 25019198 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Cytogenetic analysis was performed on 103 consecutive cultures from 68 MSCs (25 adipose-origin, 20 bone marrow-origin, 18 cord blood-origin, and 5 neural stem cells; 8 from adipose tissue of patients with breast cancer and 60 from healthy donors). | 25019198 |
| Intestinal Neuroendocrine Tumor | Stem Cell Exhaustion | An integrated cellular transcriptomic analysis of small intestinal neuroendocrine tumors identified that they are regulated at a developmental level, have key activation of hypoxic pathways (a known regulator of malignant stem cell phenotypes) as well as activation of genes involved in apoptosis and proliferation. | 25023465 |
| Specialty Type - cancer, Infection | Stem Cell Exhaustion | We evaluated the effect of cancer type, age, gender, genetic syndrome, stem cell transplantation, PRISM3 score, infections, and critical care interventions on PICU mortality. | 25023526 |
| Specialty Type - cancer, Leukemia, Myelocytic, Acute, Communicable Diseases | Stem Cell Exhaustion | Among hematologic cancer patients, stem cell transplantation, diagnosis of acute myeloid leukemia, PRISM3 score, and infection were all independently associated with PICU mortality. | 25023526 |
| Up, "Alzheimers Disease | Stem Cell Exhaustion | But their roles in the neural stem cells (NSCs), including glial precursor cells (GPCs), of Alzheimer's disease (AD) are unclear. | 25027328 |
| Cardiovascular Diseases | Stem Cell Exhaustion | Circulating endothelial progenitor cells (EPCs) reflect endothelial repair capacity and may be a significant marker for the clinical outcomes of cardiovascular disease. | 25027585 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplant for hematological malignancies from mismatched 9/10 human leukocyte antigen unrelated donors: comparison with transplants from 10/10 unrelated donors and human leukocyte antigen identical siblings. | 25029640 |
| Histogenic Process, Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Although its histogenesis and biological aspects remain poorly understood, previous studies have postulated that this tumor may arise from single cancer stem cells which subsequently differentiate into distinct tumor lineages. | 25031014 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Recent evidence suggested that tumor initiation and growth are driven by a subset of tumor-initiating cells termed cancer stem cells. | 25034654 |
| Neoplasms | Stem Cell Exhaustion | Nestin has been widely used as a marker for melanocyte stem cells as well as an angiogenic marker to evaluate neovascularity of endothelial cells in tumors. | 25034654 |
| Cutaneous Melanoma, melanoma | Stem Cell Exhaustion | To gain an insight into the impact of Notch1 activation on the maintenance of melanocyte stem cells and angiogenesis in melanoma, the expression levels of activated Notch1 and nestin were analyzed by immunohistochemistry in 114 primary cutaneous melanomas and 35 lymph node metastases. | 25034654 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Donor lymphocyte infusion for the treatment of relapsed acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation: a retrospective analysis by the Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation. | 25034960 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Because the efficacy of donor lymphocyte infusion (DLI) for acute myeloid leukemia (AML) relapse after allogeneic hematopoietic stem cell transplantation (HSCT) remains uncertain, especially in the Asian population, a nationwide registry study was retrospectively performed by the Adult AML Working Group of the Japan Society for Hematopoietic Cell Transplantation to identify the factors affecting the patient survival after DLI. | 25034960 |
| Neoplasms | Stem Cell Exhaustion | Notch pathway molecules crosstalk with Wnt/b-catenin signaling cascade in stem cells and tumors. | 25037575 |
| Fibrosis Assessment | Stem Cell Exhaustion | Mesenchymal stromal cells (MSC), a key component of the stem cell niche in bone marrow and possibly other organs including lung, have been shown to enhance epithelial repair and are effective in preclinical models of inflammation-induced pulmonary fibrosis, but may be profibrotic in some circumstances. | 25039426 |
| Aggressive Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Relapsed aggressive lymphomas are often treated with platinum-based chemotherapy (PBC) followed by an autologous stem cell transplant (ASCT). | 25039868 |
| Malignant Neoplasms | Stem Cell Exhaustion | To compare the cumulative incidence (CI), severity and mortality of IM in eras immediately before and after the commercial availability of voriconazole all IM cases from 1995 to 2011 were analysed across four risk-groups (hematologic/oncologic malignancy (H/O), stem cell transplantation (SCT), solid organ transplantation (SOT) and other), and two eras, E1 (1995-2003) and E2, (2004-2011). | 25040241 |
| Hemorrhagic cystitis | Stem Cell Exhaustion | BK virus-associated hemorrhagic cystitis (BKV-HC) is a common and major cause of morbidity in recipients of allogeneic hematopoietic stem cell transplantation. | 25040402 |
| Clostridium difficile colitis | Stem Cell Exhaustion | Risk factors for recurrent Clostridium difficile infection in hematopoietic stem cell transplant recipients. | 25040545 |
| Clostridium difficile colitis, Central Diabetes Insipidus | Stem Cell Exhaustion | Recurrent Clostridium difficile infection (CDI) represents a significant burden on the healthcare system and is associated with poor outcomes in hematopoietic stem cell transplant (HSCT) patients. | 25040545 |
| Pneumococcal Infections | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (alloHSCT) recipients are at high risk of invasive pneumococcal disease (IPD). | 25040633 |
| Hyperpigmentation, Lentigo | Stem Cell Exhaustion | It has been reported that the abnormal regulation of melanocyte stem cells (McSCs) causes hair greying; however, little is known about the role of McSCs in skin hyperpigmentation such as solar lentigines (SLs). | 25040700 |
| Lymphoma, Follicular | Stem Cell Exhaustion | The role of allogeneic (allo-) and autologous stem cell transplantation (auto-SCT) in the management of patients with transformed indolent nonfollicular non-Hodgkin lymphoma is unknown. | 25042735 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Adjusted for type of stem cell transplantation, 3-year overall survival, progression-free survival, and nonrelapse mortality rates were similar to those of patients with transformed follicular lymphoma receiving allo-SCT and auto-SCT (P = .38, P = .69, and P = .54, respectively). | 25042735 |
| B-Cell Lymphomas, Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | Infused autograft absolute lymphocyte count is a prognostic factor for survival after autologous peripheral hematopoietic stem cell transplantation (APHSCT) for diffuse large B cell lymphoma (DLBCL). | 25042737 |
| Malignant neoplasm of breast | Stem Cell Exhaustion | To determine if EZH2 is required to establish H3K27me3 marks in mammary cancer, Brca1 and Ezh2 were deleted in mammary stem cells in mice. | 25043748 |
| Juvenile Myelomonocytic Leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Clinical course of juvenile myelomonocytic leukemia in the blast crisis phase treated by acute myeloid leukemia-oriented chemotherapy and allogeneic hematopoietic stem cell transplantation. | 25047104 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Although he had several poor prognostic factors, including monosomy 7 and high HbF percentage, he achieved partial remission after treatment with acute myeloid leukemia-oriented chemotherapy followed by allogeneic hematopoietic stem cell transplantation. | 25047104 |
| Multiple Myeloma | Stem Cell Exhaustion | In Taiwan, melphalan and several novel agents are used to treat myeloma patients who are not candidate for hematopoietic stem cell transplant (HSCT). | 25047657 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | Endothelial progenitor stem cells (EPCs) are mobilized to the peripheral circulation in response to myocardial ischemia, playing a crucial role in vascular repair. | 25048407 |
| Acute myocardial infarction | Stem Cell Exhaustion | Impact of prior chronic statin therapy and high-intensity statin therapy at discharge on circulating endothelial progenitor cell levels in patients with acute myocardial infarction: a prospective observational study. | 25048407 |
| PAFAH1B1 wt Allele, Neoplasms, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Myelodysplastic syndrome (MDS) is a stem cell tumor characterized by dysplastic features and ineffective hematopoiesis in the early phase and leukemic progression in the late phase. | 25056847 |
| Anemia, Sickle Cell | Stem Cell Exhaustion | Nonmyeloablative HLA-matched sibling allogeneic hematopoietic stem cell transplantation for severe sickle cell phenotype. | 25058217 |
| Anemia, Sickle Cell, Toxic effect | Stem Cell Exhaustion | Myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) is curative for children with severe sickle cell disease, but toxicity may be prohibitive for adults. | 25058217 |
| Amyloidosis | Stem Cell Exhaustion | Oral melphalan and dexamethasone (MDex) is a standard treatment for patients with AL amyloidosis who are not eligible for stem cell transplantation at many referral centers. | 25059496 |
| Carcinogenesis | Stem Cell Exhaustion | Using an LSD1 inhibitor, CBB1003, as a probe, we studied the association between LSD1 and leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), a CRC stem cell marker involved in carcinogenesis. | 25060070 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | Variation at the CXCL12 locus is associated with coronary artery disease and endothelial progenitor cell numbers, whereas variation at the CXCR4 locus is associated with leukocyte telomere length, which has been shown to be associated with coronary artery disease. | 25060794 |
| Cardiovascular Diseases | Stem Cell Exhaustion | Therefore, we examined the relationships of plasma SDF-1 levels to cardiovascular disease (CVD)-related outcomes, risk factors, leukocyte telomere length, and endothelial progenitor cells. | 25060794 |
| Neutropenia, Malignant Neoplasms | Stem Cell Exhaustion | We compared the microbiological findings with respect to neutropenia, hematopoietic stem cell transplantation (HSCT) status, and the type of malignancy. | 25062720 |
| Leukemia, Myelomonocytic, Chronic, Hematological Disease | Stem Cell Exhaustion | Chronic myelomonocytic leukemia (CMML) is a clonal disorder of hematopoietic stem cells often occurring in elderly patients. | 25063763 |
| Thalassemia | Stem Cell Exhaustion | Outcomes of thalassemia patients undergoing hematopoietic stem cell transplantation by using a standard myeloablative versus a novel reduced-toxicity conditioning regimen according to a new risk stratification. | 25064743 |
| Thalassemia | Stem Cell Exhaustion | Improving outcomes among class 3 thalassemia patients receiving allogeneic hematopoietic stem cell transplantations (HSCT) remains a challenge. | 25064743 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Calcineurin inhibitor--free graft-versus-host disease prophylaxis with post-transplantation cyclophosphamide and brief-course sirolimus following reduced-intensity peripheral blood stem cell transplantation. | 25064745 |
| Acute GVH disease | Stem Cell Exhaustion | Synergistic effect of major histocompatibility complex class I-related chain a and human leukocyte antigen-DPB1 mismatches in association with acute graft-versus-host disease after unrelated donor hematopoietic stem cell transplantation. | 25064744 |
| Electrocardiogram: myocardial infarction (finding), diabetic | Stem Cell Exhaustion | Endothelial progenitor cells in diabetic patients with myocardial infarction - can statins improve their function? | 25066111 |
| diabetic, Acute myocardial infarction | Stem Cell Exhaustion | The effect of statins on endothelial progenitor cells (EPCs) function derived from diabetic patients (DMpts) with acute myocardial infarction (AMI) is unknown. | 25066111 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | The hematopoietic stem cell transplant comorbidity index can predict for 30-day readmission following autologous stem cell transplant for lymphoma and multiple myeloma. | 25068419 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Patients who undergo autologous stem cell transplant (ASCT) for hematologic malignancies frequently have multiple comorbidities. | 25068419 |
| Venoocclusive disease | Stem Cell Exhaustion | Incidence and risk factors for moderate-to-severe veno-occlusive disease of the liver after allogeneic stem cell transplantation using a reduced intensity conditioning regimen. | 25068424 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Indeed, longevity of AML characteristics, as well as sufficient stem cells in the xenograft model, should be guaranteed to analyze the therapeutic response to a drug. | 25069538 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Therefore, we examined whether leukapheresed peripheral blood (LPB) consists of reliable leukemic stem cells (LSCs) and ALDHdim-expressing CD34+CD38- cells, and functions in grafting human AML with virulence compared to that of BM. | 25069538 |
| Neoplasms | Stem Cell Exhaustion | These results suggest that UPS tumors share a similar lineage as leiomyosarcomas and are likely to originate from different stages of differentiation from mesenchymal stem cells to smooth muscle cells. | 25069693 |
| Agenesis | Stem Cell Exhaustion | Thus, Human herpesvirus 6 reactivation during aplasia, lower unit-unit human leukocyte antigen matching, and younger UCB unit age, as new unfavorable predictive factors, may represent new parameters to take into account after double UCB allogeneic stem-cell transplantation in adults. | 25072620 |
| B-Cell Lymphomas | Stem Cell Exhaustion | Upfront consolidation combining yttrium-90 ibritumomab tiuxetan and high-dose therapy with stem cell transplantation in poor-risk patients with diffuse large B cell lymphoma. | 25072780 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | Seventy-five high-risk (>=2 International Prognostic Index [IPI] factors) consecutive DLBCL patients (<=65 years old) in complete remission (CR) or partial remission (PR) after rituximab chemotherapy were treated with Y(90) ibritumomab tiuxetan and BEAM regimen followed by autologous stem cell transplantation (ASCT). | 25072780 |
| Lymphoma | Stem Cell Exhaustion | Among 60 lymphoma patients who had less than 30 CD34 cells/mm(3) the day before the first apheresis, an increase in the CD34 cell count between Day -1 and Day 1 was predictive of first stem cell mobilisation success, with a sensitivity of 100% if the Day 1 was higher than 30/mm(3) (10/60 patients). | 25073661 |
| Blindness | Stem Cell Exhaustion | Autologous cultivated limbal epithelial transplantation (CLET) is a successful therapy to restore corneal epithelium when limbal epithelial stem cells are damaged unilaterally, which can result in corneal blindness. | 25075515 |
| Cessation of life, Diarrhea, Clostridium difficile | Stem Cell Exhaustion | Incidence of diarrhea by Clostridium difficile in hematologic patients and hematopoietic stem cell transplantation patients: risk factors for severe forms and death. | 25076434 |
| Neutropenia, Cessation of life | Stem Cell Exhaustion | We describe the rate of incidence of Clostridium difficile-associated diarrhea (CDAD) in hematologic and patients undergone stem cell transplant (HSCT) at HC-FMUSP, from January 2007 to June 2011, using two denominators 1,000 patient and 1,000 days of neutropenia and the risk factors associated with the severe form of the disease and death. | 25076434 |
| Bare Lymphocyte Syndrome | Stem Cell Exhaustion | Passenger lymphocyte syndrome is a complication of both solid-organ and stem cell transplants. | 25077954 |
| Lesion | Stem Cell Exhaustion | Runx1 becomes highly expressed at the periphery of mouse OA lesions and in human OA chondrocyte 'clones' where Runx1 co-localizes with Vcam1, the mesenchymal stem cell (MSC) marker and lubricin (Prg4), a cartilage chondroprotective protein. | 25078095 |
| Multiple Myeloma | Stem Cell Exhaustion | Functional autoantibodies against SSX-2 and NY-ESO-1 in multiple myeloma patients after allogeneic stem cell transplantation. | 25078248 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Cytopenia | Stem Cell Exhaustion | Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders characterized by peripheral cytopenias and ineffective hematopoiesis. | 25079655 |
| Antilymphocyte Serum | Stem Cell Exhaustion | We observed the same phenomenon in freshly isolated PBMC from ALS patients (reduced 24-35%, ANOVA p < 0.001) and reproduced it in a human neural stem cell model treated with 2',3'-dideoxycytidine (ddC) (reduced 52-78%, ANOVA p < 0.001). | 25081190 |
| Specialty Type - cancer, Pancreatic carcinoma | Stem Cell Exhaustion | The IL-8/CXCR1 axis is associated with cancer stem cell-like properties and correlates with clinical prognosis in human pancreatic cancer cases. | 25081383 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | CXCR1, a receptor for CXCL8/IL-8, has recently been demonstrated to be associated with cancer stem cell (CSC) populations in certain types of human cancers. | 25081383 |
| Communicable Diseases | Stem Cell Exhaustion | Impact of pretransplant serum ferritin level on risk of invasive mold infection after allogeneic hematopoietic stem cell transplantation. | 25082161 |
| Infection | Stem Cell Exhaustion | Invasive mold infections (IMI) are life-threatening complications of allogeneic hematopoietic stem cell transplantation (HSCT) and are mostly caused by Aspergillus species and Mucorales. | 25082161 |
| Congestive heart failure | Stem Cell Exhaustion | The objective of this study was to assess a relationship between insulin resistance (IR) and counts of CD45(-)CD34(+), CD14(+)CD309(+), and CD14(+)CD309(+)Tie2(+) phenotyped circulating endothelial progenitor cells (EPCs) in patients with ischemic chronic heart failure (CHF). | 25082501 |
| JAK2 NP_004963.1:p.V617F, Polycythemia Vera | Stem Cell Exhaustion | Hematopoietic clonal dominance, stem cell mutations, and evolutionary pattern of JAK2V617F allele burden in polycythemia vera. | 25082530 |
| JAK2 NP_004963.1:p.V617F, Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase | Stem Cell Exhaustion | JAK2V617F was measured in stem cells, progenitor cells, and granulocytes of 45 patients with PV (early chronic phase n = 26, late chronic phase n = 10, post-PV MF n = 9). | 25082530 |
| Neutropenia, Trichosporon asahii, Infection of bloodstream, Pichia kudriavzevii | Stem Cell Exhaustion | There were two bloodstream infections caused by yeasts or yeast-like fungi (Candida krusei, Trichosporon asahii) in two patients during the neutropenic phase after allogeneic haematopoietic stem cell transplantation. | 25082655 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | Miconazole mucoadhesive buccal tablet in high-dose therapy with autologous stem cell transplantation (HDT/ASCT)-induced mucositis. | 25084742 |
| Gastrointestinal mucositis, Communicable Diseases | Stem Cell Exhaustion | Oral mucositis is a major cause of morbidity in high-dose therapy/autologous stem cell transplantation (HDT/ASCT), where microbial colonization has an important pathological implication. | 25084742 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Effect of graft sources on allogeneic hematopoietic stem cell transplantation outcome in adults with chronic myeloid leukemia in the era of tyrosine kinase inhibitors: a Japanese Society of Hematopoietic Cell Transplantation retrospective analysis. | 25085253 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | We retrospectively compared transplant outcomes for related bone marrow transplantation (rBMT), related peripheral blood stem cell transplantation (rPBSCT), unrelated bone marrow transplantation (uBMT), and unrelated cord blood transplantation (CBT) in 1,062 patients with chronic myeloid leukemia (CML) aged 20 years or over between January 1, 2000 and December 31, 2009 in Japan. | 25085253 |
| Myeloid neoplasm | Stem Cell Exhaustion | Reduced-toxicity conditioning prior to allogeneic stem cell transplantation improves outcome in patients with myeloid malignancies. | 25085356 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Impact of the International Prognostic Scoring System cytogenetic risk groups on the outcome of patients with primary myelodysplastic syndromes undergoing allogeneic stem cell transplantation from human leukocyte antigen-identical siblings: a retrospective analysis of the European Society for Blood and Marrow Transplantation-Chronic Malignancies Working Party. | 25085359 |
| MYELODYSPLASTIC SYNDROME, Chromosome Aberrations | Stem Cell Exhaustion | Acquired chromosomal abnormalities are important prognostic factors in patients with myelodysplastic syndromes treated with supportive care and with disease-modifying therapeutic interventions, including allogeneic hematopoietic stem cell transplantation. | 25085359 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | To assess the prognostic impact of cytogenetic characteristics after hematopoietic stem cell transplantation accurately, we investigated a homogeneous group of 523 patients with primary myelodysplastic syndromes who have received stem cells from human leukocyte antigen-identical siblings. | 25085359 |
| Anemia, Sideroblast, MYELODYSPLASTIC SYNDROME, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | In conclusion, this study shows that, in a large series of patients with primary myelodysplastic syndromes, poor-risk cytogenetics as defined by the standard International Prognostic Scoring System is associated with a relatively poor survival after allogeneic stem cell transplantation from human leukocyte antigen-identical siblings except in patients who are transplanted in refractory anemia/refractory anemia with ringed sideroblasts stage before progression to higher myelodysplastic syndrome stages. | 25085359 |
| Childhood Breast Carcinoma, Neoplasms | Stem Cell Exhaustion | MicroRNA-9 is associated with epithelial-mesenchymal transition, breast cancer stem cell phenotype, and tumor progression in breast cancer. | 25086633 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Some miRNAs, especially the miR-200 family, miR-9, and miR-155 have been reported to be associated with epithelial-mesenchymal transition (EMT) and breast cancer stem cell (BCSC) phenotypes. | 25086633 |
| Specialty Type - cancer, Adult Glioblastoma, Neoplasms | Stem Cell Exhaustion | Primary cell lines derived as neurospheres, enriched in cancer stem cells, are currently the focus of interest in glioblastoma to test new drugs, because of their tumor initiating abilities and resistance to conventional therapies. | 25088051 |
| Adult Glioblastoma, Specialty Type - cancer | Stem Cell Exhaustion | Primary cell lines enriched in cancer stem cells (CSC) have become popular models for testing new drugs for glioblastoma. | 25088051 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Myelodysplastic syndromes (MDS) are a diverse group of clonal hematopoietic stem cell malignancies that primarily affect the elderly. | 25088696 |
| Hypertrophy, Degenerative polyarthritis | Stem Cell Exhaustion | Several studies have shown that type X collagen (COL X), a marker of late-stage chondrocyte hypertrophy, is expressed in mesenchymal stem cells (MSCs) from osteoarthritis (OA) patients. | 25091567 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Somatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation. | 25092778 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | Whether these types of mutations predict outcome after allogeneic hematopoietic stem-cell transplantation (HSCT) in patients with MDS is not known. | 25092778 |
| Hodgkin Disease | Stem Cell Exhaustion | Donor lymphocyte infusion is an effective therapy for relapsed Hodgkin lymphoma after reduced-intensity allogeneic hematopoietic stem cell transplantation. | 25096222 |
| Specialty Type - cancer | Stem Cell Exhaustion | We recently reported that low dose long-term fractionated radiation concentrates cancer stem cells (CSCs). | 25098609 |
| Thrombosis | Stem Cell Exhaustion | In animals, acrolein exposure is associated with the suppression of circulating progenitor cells and increases in thrombosis and atherogenesis. | 25099132 |
| Antilymphocyte Serum | Stem Cell Exhaustion | Previously, we found that glia from mice carrying the SOD1G93A mutation, a model of ALS, were toxic to stem cell-derived human motor neurons. | 25100738 |
| Antilymphocyte Serum | Stem Cell Exhaustion | Our findings suggest that blocking DP1 may be a therapeutic strategy in ALS and demonstrate that discoveries from stem cell models of disease can be corroborated in vivo. | 25100738 |
| Amyotrophic Lateral Sclerosis, nervous system disorder, Antilymphocyte Serum | Stem Cell Exhaustion | Neurons produced from stem cells have emerged as a tool to identify new therapeutic targets for neurological diseases such as amyotrophic lateral sclerosis (ALS). | 25100738 |
| Periodontitis | Stem Cell Exhaustion | Circulating endothelial progenitor cells in periodontitis. | 25101916 |
| Periodontitis | Stem Cell Exhaustion | Circulating endothelial progenitor cells (cEPCs) are known to contribute to vascular repair, but limited data are available regarding the relationship between cEPC levels and periodontitis. | 25101916 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The ordered acquisition of Class II and Class I mutations directs formation of human t(8;21) acute myelogenous leukemia stem cell. | 25101977 |
| leukemia | Stem Cell Exhaustion | The cellular properties of leukemia stem cells (LSCs) are achieved at least through Class I and Class II mutations that generate signals for enhanced proliferation and impaired differentiation, respectively. | 25101977 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Here we show that in t(8;21) acute myelogenous leukemia (AML), hematopoietic stem cells (HSCs) transform into LSCs via definitively-ordered acquisition of Class II (AML1/ETO) and then Class I (c-KIT mutant) abnormalities. | 25101977 |
| Fracture | Stem Cell Exhaustion | Using a small animal model of long-bone fracture healing based on chronologic age, we asked how aging affected (1) the amount, density, and proportion of bone formed during healing; (2) the amount of cartilage produced and the progression to bone during healing; (3) the callus structure and timing of the fracture healing; and (4) the behavior of progenitor cells relative to the observed deficiencies of geriatric fracture healing. | 25106797 |
| Cerebrovascular accident | Stem Cell Exhaustion | Intra-Arterial Immunoselected CD34+ Stem Cells for Acute Ischemic Stroke. | 25107583 |
| Ischemic stroke, Cerebrovascular accident | Stem Cell Exhaustion | We performed a prospective, nonrandomized, open-label, phase I study of autologous, immunoselected CD34+ stem/progenitor cell therapy in patients presenting within 7 days of onset with severe anterior circulation ischemic stroke (National Institutes of Health Stroke Scale [NIHSS] score>=8). | 25107583 |
| Ischemic stroke, Infarction | Stem Cell Exhaustion | Autologous CD34+ selected stem/progenitor cell therapy delivered intra-arterially into the infarct territory can be achieved safely in patients with acute ischemic stroke. | 25107583 |
| Ischemic stroke | Stem Cell Exhaustion | Treatment with CD34+ hematopoietic stem/progenitor cells has been shown to improve functional recovery in nonhuman models of ischemic stroke via promotion of angiogenesis and neurogenesis. | 25107583 |
| Aplastic Anemia, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Myelodysplastic syndrome evolving from aplastic anemia treated with immunosuppressive therapy: efficacy of hematopoietic stem cell transplantation. | 25107891 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | We identified 123 patients with post-aplastic anemia myelodysplastic syndrome who from 1991 through 2011 underwent allogeneic hematopoietic stem cell transplantation, and in a matched-pair analysis compared outcome to that in 393 patients with de novo myelodysplastic syndrome. | 25107891 |
| Vascular calcification | Stem Cell Exhaustion | Wnt5a is associated with the differentiation of bone marrow mesenchymal stem cells in vascular calcification by connecting with different receptors. | 25109262 |
| Amyloidosis | Stem Cell Exhaustion | Plerixafor and abbreviated-course granulocyte colony-stimulating factor for mobilizing hematopoietic progenitor cells in light chain amyloidosis. | 25111581 |
| Amyloidosis | Stem Cell Exhaustion | We analyzed hematopoietic progenitor cells (HPC) mobilization outcomes in 49 consecutive AL amyloidosis patients at our institution between 2004 and 2013 with granulocyte colony-stimulating factor (G) (10 mg/kg/day) (n = 25) versus an institutional protocol to limit G exposure using plerixafor (P) (.24 mg/kg s.c. starting day 3 of G 10 mg/kg) (n = 24). | 25111581 |
| Ovarian Insufficiency | Stem Cell Exhaustion | Ovarian insufficiency and pubertal development after hematopoietic stem cell transplantation in childhood. | 25111958 |
| Ovarian Insufficiency, Specialty Type - cancer, Non-host Organism Identifiers Domain, Infertility | Stem Cell Exhaustion | Ovarian insufficiency (OI) and infertility are common and devastating late effects of cancer treatment and hematopoietic stem cell transplantation (HSCT). | 25111958 |
| Bone necrosis | Stem Cell Exhaustion | Icariin may benefit the mesenchymal stem cells of patients with steroid-associated osteonecrosis by ABCB1-promoter demethylation: a preliminary study. | 25112719 |
| Bone necrosis | Stem Cell Exhaustion | In this study, we found out a previously undefined function of icariin which restored the dynamic balance between osteogenic and adipogenic differentiation of mesenchymal stem cells (MSCs) in patients with osteonecrosis of femoral head (ONFH) via ABCB1-promoter demethylation. | 25112719 |
| BCR gene | Stem Cell Exhaustion | Complete remission rate, remission duration, and overall survival were not significantly different according to the presence of CK or MK in the whole series, according to the B or T lineage, in the high-risk group, or in patients with t(9;22), regardless of imatinib treatment, and in patients who received chemotherapy alone or chemotherapy followed by stem cell transplantation Our study shows that CK and MK were not associated with a worse prognosis in adult patients with ALL treated with risk-adapted or subtype-oriented protocols. | 25116331 |
| Pfaundler-Hurler Syndrome | Stem Cell Exhaustion | Unrelated CD3/CD19-depleted peripheral stem cell transplantation for Hurler syndrome. | 25116402 |
| Mucopolysaccharidoses, Intrahepatic Route of Drug Administration, Pfaundler-Hurler Syndrome | Stem Cell Exhaustion | For patients with mucopolysaccharidosis type IH (MPS1-H; Hurler syndrome), early allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of choice. | 25116402 |
| Graft-vs-Host Disease, Toxic effect | Stem Cell Exhaustion | Treosulfan-based conditioning offers the advantage of reduced toxicity; the use of unrelated CD3/CD19-depleted peripheral stem cell grafts allows transfusion of high CD34+ cell numbers together with a "tailored" number of CD3+ cells as well as engraftment facilitating cells in order to achieve rapid hematopoietic engraftment while reducing the risk of graft rejection and GVHD. | 25116402 |
| Brachial Plexus Block | Stem Cell Exhaustion | On day 14, 2.8 ml stem cell inoculum was infused under local anesthesia in right brachial plexus sheath by brachial block technique under ultrasonography guidance with a 1.5-inch-long 23 gauge needle. | 25116721 |
| Coma, Post-Head Injury | Stem Cell Exhaustion | Co-infusion of autologous adipose tissue derived neuronal differentiated mesenchymal stem cells and bone marrow derived hematopoietic stem cells, a viable therapy for post-traumatic brachial plexus injury: a case report. | 25116721 |
| Multiple Myeloma | Stem Cell Exhaustion | Plerixafor is effective given either preemptively or as a rescue strategy in poor stem cell mobilizing patients with multiple myeloma. | 25117969 |
| Multiple Myeloma | Stem Cell Exhaustion | Harvest of more than one CD34+ stem cell transplant has become the standard, to ensure the option for a second autologous transplantation in patients with relapsed or progressive multiple myeloma (MM). | 25117969 |
| Multiple Myeloma | Stem Cell Exhaustion | Based on the presented data, we propose an algorithm for the use of plerixafor for CD34+ stem cell mobilization and harvesting in poor mobilizing myeloma patients. | 25117969 |
| Malignant tumor of cervix, Specialty Type - cancer | Stem Cell Exhaustion | Hiwi facilitates chemoresistance as a cancer stem cell marker in cervical cancer. | 25119492 |
| Specialty Type - cancer | Stem Cell Exhaustion | In addition, as a cancer stem cell marker, Hiwi promoted the tumorsphere formation in vitro and tumorigenicity in vivo and elevated the expression of several stem cell self-renewal-associated transcription factors, in spite of inhibited the proliferation. | 25119492 |
| Malignant Neoplasms | Stem Cell Exhaustion | Hiwi, also named PiwiL1, is a human homologue of the Piwi family which is associated with stem cells and is overexpressed in several types of cancers. | 25119492 |
| diabetic | Stem Cell Exhaustion | The purpose of this study was to analyze whether adipose-derived mesenchymal stem cells (AD-MSCs) sourced from diabetic and elderly patients have a reduced ability to promote human smooth muscle cell (SMC) migration and differentiation potential toward SMCs, two important processes in stem cell-based tissue engineering of vascular grafts. | 25119584 |
| diabetic | Stem Cell Exhaustion | Autologous tissue-engineered blood vessels (TEBVs) generated using adult stem cells have shown promising results, but many preclinical evaluations do not test the efficacy of stem cells from patient populations likely to need therapy (i.e., elderly and diabetic humans). | 25119584 |
| Glioma, Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cell-related (CSC) markers have been suggested to have promising potentials as novel types of prognostic and predictive markers in gliomas. | 25120750 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | The specific mechanism underlying the role of putative stem cell marker aldehyde dehydrogenase 1 (ALDH1) playing in development and progression of breast cancer is currently unclear. | 25120797 |
| Aplastic Anemia | Stem Cell Exhaustion | Graft failure and survival are the major problems for patients with aplastic anemia undergoing hematopoietic stem cell transplantation (HSCT). | 25123053 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Yet, the expressions of EMT markers, EMT core regulators, and a stem cell marker of BMI1 during chemotherapy have been poorly analyzed in clinical breast cancer specimens. | 25123151 |
| Spinal Cord Injuries | Stem Cell Exhaustion | Long-distance axonal growth from human induced pluripotent stem cells after spinal cord injury. | 25123310 |
| Spinal Cord Injuries | Stem Cell Exhaustion | Human induced pluripotent stem cells (iPSCs) from a healthy 86-year-old male were differentiated into neural stem cells and grafted into adult immunodeficient rats after spinal cord injury. | 25123310 |
| Chronic heart failure | Stem Cell Exhaustion | Predictive value of apoptotic microparticles to mononuclear progenitor cells ratio in advanced chronic heart failure patients. | 25123603 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | Concentrations of cutaneous T-cell attracting chemokine, eotaxin, hepatocyte growth factor, interleukin 6 (IL-6), IL-16, and stem cell factor are significantly higher in COPD patients compared with in control patients. | 25125975 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | Notably, this study identifies stem cell factor as a biomarker for COPD. | 25125975 |
| Specialty Type - cancer | Stem Cell Exhaustion | Experimental evidences found in cancer cells a deregulated expression of some genes involved in governance of stem cell properties and demonstrated a relationship between stemness genes overexpression and poorly differentiated BC subtypes. | 25127259 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Necessary stem cell transplantation using myeloablative therapy for myelodysplastic syndrome with progression of genotypic abnormalities and TP53 dysfunction in a young adult. | 25130056 |
| Lymphoma, Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Collection of sufficient CD34+ cells for autologous peripheral blood stem cell (PBSC) transplantation is frequently failed in patients with lymphoma or multiple myeloma (MM). | 25130876 |
| leukemia | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation for T-prolymphocytic leukemia: a report from the French society for stem cell transplantation (SFGM-TC). | 25130897 |
| leukemia | Stem Cell Exhaustion | Leukemia cells invaded the central nervous system following hematopoietic stem cell transplantation, and the patient died 5 months after being diagnosed with leukemia. | 25131874 |
| Allogeneic Hematopoietic Stem Cell Transplantation, Hematologic Neoplasms | Stem Cell Exhaustion | Sequential infusion of donor-derived dendritic cells with donor lymphocyte infusion for relapsed hematologic cancers after allogeneic hematopoietic stem cell transplantation. | 25132538 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | Incidence and dynamics of active cytomegalovirus infection in allogeneic stem cell transplant patients according to single nucleotide polymorphisms in donor and recipient CCR5, MCP-1, IL-10, and TLR9 genes. | 25132583 |
| Cytomegalovirus DNA | Stem Cell Exhaustion | The current study aimed to investigate whether donor and recipient SNPs in the chemokine receptor 5 (rs1800023), monocyte chemoattractant protein 1 (rs13900), interleukin-10 (rs1878672), and Toll-like receptor 9 (rs352140) genes would exert any influence on the rate of incidence and features of CMV DNAemia in the allogeneic stem cell transplantation setting. | 25132583 |
| Anger, Usual Severity Pain | Stem Cell Exhaustion | Anger, provider responses, and pain: prospective analysis of stem cell transplant patients. | 25133836 |
| Multiple Myeloma | Stem Cell Exhaustion | We examined whether elevated serum LDH at diagnosis remains an adverse risk factor independent of ISS for survivals transplant-eligible myeloma patients receiving early/frontline bortezomib-based induction, followed by autologous stem cell transplantation (ASCT). | 25135740 |
| Blastic plasmacytoid dendritic cell neoplasm | Stem Cell Exhaustion | Sustained remission of blastic plasmacytoid dendritic cell neoplasm after unrelated allogeneic stem cell transplantation--a single center experience. | 25138222 |
| Chronic Ocular Graft Versus Host Disease, Dry Eye Syndromes, Stable chronic Graft vs Host Disease | Stem Cell Exhaustion | To first describe in vivo confocal microscopic (IVCM) corneal findings in severe dry eye syndrome due to ocular chronic graft versus host disease (cGvHD) after allogeneic stem cell transplantation. | 25138762 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | Cytomegalovirus infection in patients who underwent allogeneic hematopoietic stem cell transplantation in Portugal: a five-year retrospective review. | 25139217 |
| Communicable Diseases | Stem Cell Exhaustion | Cytomegalovirus (CMV) infection is 1 of the leading causes of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (aHSCT), mainly within the first 100 days after transplantation. | 25139217 |
| Multiple Myeloma | Stem Cell Exhaustion | Safety and efficacy of targeted-dose busulfan and bortezomib as a conditioning regimen for patients with relapsed multiple myeloma undergoing a second autologous blood progenitor cell transplantation. | 25139216 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | Results of allogeneic stem cell transplantation in the Spanish MDS registry: prognostic factors for low risk patients. | 25139847 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | Although new agents have been approved for the treatment of MDS, the only curative approach is allogeneic hematopoietic stem cell transplantation (HSCT) and thus, in particular circumstances this procedure has been proposed as a treatment option for low risk patients. | 25139847 |
| Spermatocytic seminoma, Seminoma, Neoplasms, Nonseminomatous | Stem Cell Exhaustion | The current opinion is that seminoma and nonseminomatous germ cell tumors develop from a common primitive progenitor cell, whereas spermatocytic seminomas develop from differentiated spermatogonia. | 25141494 |
| Chronic granulomatous disease | Stem Cell Exhaustion | Mobilization characteristics and strategies to improve hematopoietic progenitor cell mobilization and collection in patients with chronic granulomatous disease and severe combined immunodeficiency. | 25143186 |
| Chronic granulomatous disease | Stem Cell Exhaustion | Granulocyte-colony-stimulating factor (G-CSF)-mobilized autologous hematopoietic progenitor cells (HPCs) may be collected by apheresis of patients with chronic granulomatous disease (CGD) and severe combined immunodeficiency (SCID) for use in gene therapy trials. | 25143186 |
| Disease | Stem Cell Exhaustion | Our findings present the concept of organotopic transplantation of macrophage progenitors as an effective and long-lasting therapy of herPAP and may also serve as a proof of principle for other diseases, expanding current stem cell-based strategies toward potent concepts using the transplantation of differentiated cells. | 25143363 |
| Reperfusion Injury | Stem Cell Exhaustion | Effect of preemptive treatment with human umbilical cord blood-derived mesenchymal stem cells on the development of renal ischemia-reperfusion injury in mice. | 25143451 |
| Immune-mediated | Stem Cell Exhaustion | Human umbilical cord blood-derived mesenchymal stem cells (HUCB-MSCs) have been studied in several models of immune-mediated disease because of their unique immunomodulatory properties. | 25143451 |
| Neuroendocrine Tumors, Malignant neoplasm of lung | Stem Cell Exhaustion | We evaluated the expression of the oncofetal protein IMP3 in a series of neuroendocrine tumors of the lung, correlating our results with proliferating index Ki67 and with the expression of the two most studied stem cell markers in lung cancer, Nanog and Oct3/4. | 25144243 |
| Neuroendocrine Tumors | Stem Cell Exhaustion | IMP3 is a marker of poor outcome in lung neuroendocrine tumors; its correlation with Nanog expression suggest an implication of IMP3 in stem cell processes and its association with a Ki67 labeling index higher than 4% stratifies a subset of atypical carcinoids with a higher risk of recurrence and mortality. | 25144243 |
| Graft-vs-Host Disease, Myelosuppression, Lymphoma | Stem Cell Exhaustion | Myelosuppression, graft-versus-host disease (GVHD), and relapse remain major causes of morbidity after stem cell transplantation for relapsed lymphoma. | 25145344 |
| Squamous cell carcinoma of esophagus | Stem Cell Exhaustion | A retrospective review of the prognostic value of ALDH-1, Bmi-1 and Nanog stem cell markers in esophageal squamous cell carcinoma. | 25148045 |
| Malignant Neoplasms | Stem Cell Exhaustion | Stem cell markers are upregulated in various cancers and have potential as prognostic indicators. | 25148045 |
| Extrapulmonary Small Cell Carcinoma, Squamous cell carcinoma of esophagus, leukemia | Stem Cell Exhaustion | The objective of this study was to determine the expression of three stem cell markers, aldehyde dehydrogenase 1 (ALDH-1), B cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1), and Nanog, in esophageal squamous cell carcinoma (ESCC) tissues. | 25148045 |
| Extrapulmonary Small Cell Carcinoma | Stem Cell Exhaustion | Further large studies are necessary to fully elucidate the prognostic value of these stem cell markers for ESCC patients. | 25148045 |
| Aggressive Non-Hodgkin Lymphoma, tetraxetan | Stem Cell Exhaustion | We evaluated the anti-CD22 (90)Y-epratuzumab tetraxetan with the anti-CD20 veltuzumab in patients with aggressive lymphoma in whom at least one prior standard treatment had failed, but who had not undergone stem cell transplantation. | 25150258 |
| Osteoporotic Fractures | Stem Cell Exhaustion | Mesenchymal stem cells from osteoporotic patients reveal reduced migration and invasion upon stimulation with BMP-2 or BMP-7. | 25152406 |
| Fracture | Stem Cell Exhaustion | Human mesenchymal stem cells (hMSC), the cellular source of fracture healing, are recruited to the fracture site by cytokines, such as BMP-2 and BMP-7. | 25152406 |
| Aggressive course | Stem Cell Exhaustion | MicroRNA-101 targets EZH2, MCL-1 and FOS to suppress proliferation, invasion and stem cell-like phenotype of aggressive endometrial cancer cells. | 25153722 |
| Hepatitis B, REG1CP gene | Stem Cell Exhaustion | Hepatitis B virus (HBV) reverse seroconversion (RS) can be prevented even in non-responders to hepatitis B vaccine after allogeneic stem cell transplantation: long-term analysis of intervention in RS with vaccine for patients with previous HBV infection. | 25154638 |
| Hepatitis B, REG1CP gene, Communicable Diseases | Stem Cell Exhaustion | Reactivation of hepatitis B virus (HBV) infection, reverse seroconversion (RS), is a serious complication after allogeneic stem cell transplantation (alloHSCT). | 25154638 |
| Mastocytosis | Stem Cell Exhaustion | Hematopoietic stem-cell transplantation for advanced systemic mastocytosis. | 25154823 |
| Neurodegenerative Disorders | Stem Cell Exhaustion | Developing neural stem cell-based treatments for neurodegenerative diseases. | 25157920 |
| Alzheimers Disease | Stem Cell Exhaustion | The recent discovery by Blurton-Jones and colleagues that neural stem cells can effectively deliver disease-modifying therapeutic proteins throughout the brains of our best rodent models of Alzheimer's disease, combined with recent advances in human nuclear reprogramming, stem cell research, and highly customized genetic engineering, may represent a potentially revolutionary personalized cellular therapeutic approach capable of effectively curing, ameliorating, and/or slowing the progression of Alzheimer's disease. | 25157920 |
| Medial collateral ligament | Stem Cell Exhaustion | For younger patients, intensive approaches followed by autologous stem cell transplantation offer excellent long-term disease control but with the possible exception of an allogenic stem cell transplant, MCL is an incurable condition. | 25158606 |
| Psoriasis | Stem Cell Exhaustion | Characterization and profiling of immunomodulatory genes in resident mesenchymal stem cells reflect the Th1-Th17/Th2 imbalance of psoriasis. | 25160906 |
| Psoriasis | Stem Cell Exhaustion | The microenvironment exerts a control on the phenotype of resident mesenchymal stem cells (MSCs) into the skin of psoriasis patients. | 25160906 |
| Polycythemia Vera | Stem Cell Exhaustion | Polycythemia vera is the ultimate phenotypic consequence of the V617F mutation in Janus kinase 2 (encoded by JAK2), but the extent to which this mutation influences the behavior of the involved CD34+ hematopoietic stem cells is unknown. | 25162887 |
| Neoplasms | Stem Cell Exhaustion | Differences among brain tumor stem cell types and fetal neural stem cells in focal regions of histone modifications and DNA methylation, broad regions of modifications, and bivalent promoters. | 25163646 |
| Glioblastoma Multiforme Pathway, Neoplasms | Stem Cell Exhaustion | Using ChIP-chip and MeDIP-chip approaches, we localized well-established and prevalent epigenetic marks (H3K27me3, H3K4me3, H3K9me3, DNA methylation) on a genome scale in several lines of putative glioma stem cells (brain tumor stem cells, BTSCs) and, for comparison, normal human fetal neural stem cells (fNSCs). | 25163646 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Metastatic consequences of immune escape from NK cell cytotoxicity by human breast cancer stem cells. | 25164008 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Lower dose of antithymocyte globulin does not increase graft-versus-host disease in patients undergoing reduced-intensity conditioning allogeneic hematopoietic stem cell transplant. | 25166008 |
| Chronic Obstructive Airway Disease, physiopathological | Stem Cell Exhaustion | Circulating progenitor cells and vascular dysfunction in chronic obstructive pulmonary disease. | 25171153 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | In chronic obstructive pulmonary disease (COPD), decreased progenitor cells and impairment of systemic vascular function have been suggested to confer higher cardiovascular risk. | 25171153 |
| Pulmonary Hypertension | Stem Cell Exhaustion | To investigate whether changes in the number of circulating hematopoietic progenitor cells are associated with pulmonary hypertension or changes in endothelial function. | 25171153 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | Compared with controls, the number of circulating progenitor cells was reduced in COPD patients. | 25171153 |
| Chronic Obstructive Airway Disease, Pulmonary Hypertension | Stem Cell Exhaustion | COPD patients with pulmonary hypertension showed greater number of progenitor cells than those without pulmonary hypertension. | 25171153 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | In COPD patients, the number of circulating progenitor cells was inversely related to the flow-mediated dilation of systemic arteries. | 25171153 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Uric acid (UA) is a known danger signal and is released from injured cells during conditioning for allogeneic hematopoietic stem cell transplantation (HSCT), but its role in GVHD is unclear. | 25172456 |
| TCL4 gene, Adult T-Cell Lymphoma/Leukemia | Stem Cell Exhaustion | Allogeneic bone marrow and peripheral blood stem cell transplantations are curative treatment modalities for adult T cell leukemia/lymphoma (ATLL) because of the intrinsic graft-versus-ATLL effect. | 25172635 |
| Malignant neoplasm of stomach, Malignant Neoplasms | Stem Cell Exhaustion | CD24 is a heavily glycosylated cell surface protein that is expressed in putative stem cells and is overexpressed in various human malignancies, yet the significant roles of CD24 in gastric cancer development are still elusive. | 25174257 |
| Neoplasms, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | These observations warrant further research on CART-33 treatment in refractory AML and may spur efforts to extend the CART-33-induced tumor burden to the preparation of other intensive strategies, such as hematopoietic stem cell transplantation. | 25174587 |
| Mantle cell lymphoma | Stem Cell Exhaustion | R-CHOP or R-HyperCVAD with or without autologous stem cell transplantation for older patients with mantle cell lymphoma. | 25174772 |
| Medial collateral ligament, Mantle cell lymphoma | Stem Cell Exhaustion | Although intensive induction and autologous stem cell transplantation (ASCT) prolong survival in younger patients with mantle cell lymphoma (MCL), benefit in older patients remains uncertain because data supporting these approaches come almost exclusively from younger cohorts. | 25174772 |
| Infancy, Medulloblastoma | Stem Cell Exhaustion | Proposed strategy for the use of high-dose chemotherapy with stem cell rescue and intrathecal topotecan without whole-brain irradiation for infantile classic medulloblastoma. | 25174961 |
| Amyloidosis | Stem Cell Exhaustion | Marked and rapid regression of hepatic amyloid deposition in a patient with systemic light chain (AL) amyloidosis after high-dose melphalan therapy with stem cell transplantation. | 25175136 |
| Prostate carcinoma | Stem Cell Exhaustion | Differential expression of stem cell markers and ABCG2 in recurrent prostate cancer. | 25175483 |
| Neoplasms, Passive Cutaneous Anaphylaxis | Stem Cell Exhaustion | The aim of this research is to investigate expressions of stem cell markers in recurrent PCa and non-recurrent PCa tumors as well as in adjacent normal prostate tissues. | 25175483 |
| Specialty Type - cancer | Stem Cell Exhaustion | Enhanced expression of ABCG2 and stem cell markers including SOX2, OCT4, and KLF4 in the recurrent PCa tissues postulates the suggestion that enrichment for cells with stem cell characteristics in these tissues might be playing a critical role for chemoresistance and recurrence of cancer. | 25175483 |
| Specialty Type - cancer, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Cancer stem cells are composed of a small cell population, which are supposed to have roles in tumorigenesis, metastasis, and tumor recurrence after chemo-radiotherapy. | 25175483 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Favorable outcomes in elderly patients undergoing high-dose therapy and autologous stem cell transplantation for non-Hodgkin lymphoma. | 25175794 |
| Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | High-dose therapy and autologous stem cell transplantation (HDT-ASCT) can offer potential long-term remission or cure in patients with non-Hodgkin lymphoma (NHL). | 25175794 |
| Myeloproliferative disease, Malignant Neoplasms, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of the hematopoietic stem cell that is exceptionally rare in the first five years of life, particularly as a secondary malignancy. | 25175922 |
| Carcinoma | Stem Cell Exhaustion | The characterization of stem cell in this type of carcinoma could determine the appearance of new ideas concerning origin and evolution. | 25178326 |
| Noninfiltrating Intraductal Carcinoma | Stem Cell Exhaustion | There is an impressive amount of data in the literature related to TNBC and a growing interest for stem cell research during the past years, but there are no data concerning the genetic characterization of stem cells in the context of cell biology of TNBC as compared with associated DCIS. | 25178326 |
| Noninfiltrating Intraductal Carcinoma | Stem Cell Exhaustion | We performed immunohistochemical studies for the expression and distribution of several stem cell-related antigens, focusing on the association of TNBC with DCIS and comparing the presence of stem cells in the invasive and in the in situ component. | 25178326 |
| Breast Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells biomarkers in triple negative invasive carcinoma of the breast and associated in situ lesions. | 25178326 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Optimization of detection, identification and characterization of tumorigenic breast cancer stem cells might permit further identification of targeted treatment. | 25178326 |
| Ptosis | Stem Cell Exhaustion | This is an observational study is designed to assess the influence of age, prolapse and medical co-morbidities on myogenic stem cells growth in-vitro. | 25181379 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | The emergence of oligoclonal bands (OB) has been reported in patients with multiple myeloma (MM) after stem cell transplantation (SCT) or successful chemotherapy. | 25182124 |
| Multiple Myeloma | Stem Cell Exhaustion | This open-label, randomized, phase 3 study compared melphalan at a dose of 200 mg per square meter of body-surface area plus autologous stem-cell transplantation with melphalan-prednisone-lenalidomide (MPR) and compared lenalidomide maintenance therapy with no maintenance therapy in patients with newly diagnosed multiple myeloma. | 25184862 |
| Cessation of life | Stem Cell Exhaustion | Both progression-free and overall survival were significantly longer with high-dose melphalan plus stem-cell transplantation than with MPR (median progression-free survival, 43.0 months vs. 22.4 months; hazard ratio for progression or death, 0.44; 95% confidence interval [CI], 0.32 to 0.61; P<0.001; and 4-year overall survival, 81.6% vs. 65.3%; hazard ratio for death, 0.55; 95% CI, 0.32 to 0.93; P=0.02). | 25184862 |
| Multiple Myeloma | Stem Cell Exhaustion | Consolidation therapy with high-dose melphalan plus stem-cell transplantation, as compared with MPR, significantly prolonged progression-free and overall survival among patients with multiple myeloma who were 65 years of age or younger. | 25184862 |
| Multiple Myeloma | Stem Cell Exhaustion | The combination melphalan-prednisone-thalidomide (MPT) is considered a standard therapy for patients with myeloma who are ineligible for stem-cell transplantation. | 25184863 |
| Multiple Myeloma | Stem Cell Exhaustion | As compared with MPT, continuous lenalidomide-dexamethasone given until disease progression was associated with a significant improvement in progression-free survival, with an overall survival benefit at the interim analysis, among patients with newly diagnosed multiple myeloma who were ineligible for stem-cell transplantation. | 25184863 |
| Vascular neoplasm of skin, Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | An agent-based model of cancer stem cell initiated avascular tumour growth and metastasis: the effect of seeding frequency and location. | 25185580 |
| Vascular neoplasm of skin, Childhood Breast Carcinoma | Stem Cell Exhaustion | Here, we investigate stem cell seeding to an avascular tumour site using an agent-based stochastic model of breast cancer metastatic seeding. | 25185580 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | There is increasing evidence that cancer stem cells are closely linked to the progression of the metastatic tumour. | 25185580 |
| Multiple Myeloma | Stem Cell Exhaustion | Activation of LTBP3 gene by a long noncoding RNA (lncRNA) MALAT1 transcript in mesenchymal stem cells from multiple myeloma. | 25187517 |
| Multiple Myeloma | Stem Cell Exhaustion | Here we explored the biology of the lncRNA MALAT1 and considered the potential significance in mesenchymal stem cells from myeloma patients. | 25187517 |
| Neoplasms | Stem Cell Exhaustion | Supervised analyses reveal that pure basaloid tumors display a specific mRNA expression profile, encoding factors controlling the cell cycle, transcription, chromatin, and splicing, with prevalent expression in germline and stem cells, while genes related to squamous differentiation are underexpressed. | 25189482 |
| Endothelial dysfunction | Stem Cell Exhaustion | Among these, an altered balance between endothelial microparticle (EMP) release and endothelial progenitor cell (EPC) generation promotes endothelial dysfunction. | 25190637 |
| Sjogrens Syndrome | Stem Cell Exhaustion | Characterization of circulating endothelial microparticles and endothelial progenitor cells in primary Sjogren's syndrome: new markers of chronic endothelial damage? | 25190637 |
| Kidney Failure, Acute | Stem Cell Exhaustion | Urinary liver-type fatty acid-binding protein linked with increased risk of acute kidney injury after allogeneic stem cell transplantation. | 25193082 |
| Kidney Failure, Acute | Stem Cell Exhaustion | Stem cell transplantation (SCT) involves a great risk of acute kidney injury (AKI). | 25193082 |
| Bipolar Disorder | Stem Cell Exhaustion | The study aims to evaluate the mediating effect of depressive symptoms on the relationship between physical symptoms and health-related quality of life (HRQOL) in hematopoietic stem cell transplant (HSCT) survivors and to test a conceptual model of psychosocial factors, in addition to physical and psychological symptoms, that might contribute to HRQOL. | 25193598 |
| Primary Myelofibrosis | Stem Cell Exhaustion | JAK2 inhibitors do not affect stem cells present in the spleens of patients with myelofibrosis. | 25193869 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | ALOX5 is implicated in chronic myeloid leukemia development in mouse leukemic stem cells, but its importance in human chronic myeloid leukemia is unknown. | 25193960 |
| Gammopathy, Multiple Myeloma | Stem Cell Exhaustion | Secondary monoclonal gammopathy of undetermined significance after allogeneic stem cell transplantation in multiple myeloma. | 25193963 |
| Gammopathy | Stem Cell Exhaustion | In this retrospective single center analysis, we describe the occurrence and clinical relevance of secondary monoclonal gammopathy of undetermined significance after allogeneic stem cell transplantation (post-transplant monoclonal gammopathy of undetermined significance). | 25193963 |
| Multiple Myeloma | Stem Cell Exhaustion | A total of 138 patients who had undergone 139 allogeneic stem cell transplantations (39.6% in the upfront setting and 60.4% for relapsed multiple myeloma) were included in the study. | 25193963 |
| Gammopathy | Stem Cell Exhaustion | Secondary monoclonal gammopathy of undetermined significance occurred more often in patients who achieved at least very good partial response after allogeneic stem cell transplantation, compared to partial response or less (54.8% vs. 26.5%; P=0.005). | 25193963 |
| Lymphoma, Follicular, Lymphoma | Stem Cell Exhaustion | The impact of total body irradiation on the outcome of patients with follicular lymphoma treated with autologous stem-cell transplantation in the modern era: a retrospective study of the EBMT Lymphoma Working Party. | 25193988 |
| Lymphoma, Follicular | Stem Cell Exhaustion | The aim of this study was to investigate the impact of the high-dose regimen on the outcome of patients with follicular lymphoma (FL) having had autologous stem-cell transplantation (ASCT) in a recent time period. | 25193988 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Outcome of allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia patients with central nervous system involvement. | 25196856 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Therefore, CNS involvement in AML is an indicator for allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 25196856 |
| Diabetes Mellitus, Insulin-Dependent, diabetic | Stem Cell Exhaustion | Combined therapy of insulin-producing cells and haematopoietic stem cells offers better diabetic control than only haematopoietic stem cells' infusion for patients with insulin-dependent diabetes. | 25199184 |
| Failure, Specialty Type - cancer, Hypoxia | Stem Cell Exhaustion | Hypoxia induced by antiangiogenic agents is linked to the generation of cancer stem cells (CSCs) and treatment failure through unknown mechanisms. | 25200065 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The malignant cell population of acute myeloid leukemia (AML) includes a small population of stem/progenitor cells with long-term in vitro proliferation. | 25200484 |
| Immunoblastic Large-Cell Lymphoma | Stem Cell Exhaustion | Plasmablastic lymphoma of the breast in an immunocompetent patient: long-lasting complete response induced by chemotherapy and autologous stem cell trasplantation. | 25202100 |
| Intervertebral Disk Displacement | Stem Cell Exhaustion | Gene expression profile analysis of human mesenchymal stem cells from herniated and degenerated intervertebral discs reveals different expression of osteopontin. | 25203751 |
| Acute myocardial infarction | Stem Cell Exhaustion | Detection of CD34/CXCR4+ stem cells in peripheral blood of patients following acute myocardial infarction. | 25204042 |
| Chest Pain, Diabetes, Myocardial Reperfusion Injury, Acute myocardial infarction | Stem Cell Exhaustion | The aim of this study was to answer the question whether acute myocardial infarction (AMI) related stress may trigger the increase of CD34/CXCR4+ stem cells number in peripheral blood in response to myocardial ischemic injury which might be accompanied with increased release of this population of stem cells in peripheral blood as well as to correlate this phenomenon with other clinical and laboratory parameters such as diabetes, chest pain, smoking, streptokinase administration and elevated cardiac enzymes. | 25204042 |
| Chemical injury, Infarction | Stem Cell Exhaustion | In conclusion, there is a pool of CD34/CXCR4+ stem cells circulating in large number in peripheral blood of AMI patients post infarction together with low CXCR4 expression on these cells which are likely to contribute to myocardial repair following the acute ischemic injury. | 25204042 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Phase 2 trial of high-dose rituximab with high-dose cytarabine mobilization therapy and high-dose thiotepa, busulfan, and cyclophosphamide autologous stem cell transplantation in patients with central nervous system involvement by non-Hodgkin lymphoma. | 25204639 |
| Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | High-dose thiotepa, busulfan, and cyclophosphamide (TBC) with autologous stem cell transplantation (ASCT) has been used in patients with central nervous system (CNS) involvement by non-Hodgkin lymphoma (NHL). | 25204639 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | We conclude that the incidence of TB is significantly higher in CML patients of male sex, aged >= 60, having received either stem cell transplantation or interferon-a treatment. | 25208807 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Combined carboplatin/paclitaxel treatment of PDX tumors enriches the cancer stem cell populations, but persistent tumors are not entirely composed of these populations. | 25209969 |
| Specialty Type - cancer | Stem Cell Exhaustion | The importance of the endothelium in angiogenesis and cancer is undisputed, and its integrity may be assessed by laboratory markers such as circulating endothelial cells (CECs), endothelial progenitor cells (EPCs), plasma von Willebrand factor (vWf), soluble E selectin, vascular endothelial growth factor (VEGF) and angiogenin. | 25211664 |
| Lichen Planus | Stem Cell Exhaustion | Interferon-g regulates the function of mesenchymal stem cells from oral lichen planus via indoleamine 2,3-dioxygenase activity. | 25212102 |
| Hearing Loss, Partial | Stem Cell Exhaustion | Endothelial progenitor cells in patients with age-related hearing loss. | 25212104 |
| Hearing Loss, Partial | Stem Cell Exhaustion | The possible role of circulating epithelial progenitor cells in the pathogenesis of age related hearing loss should be considered based on their significant reduction in patients with ARHL, although the association alone does not prove causality. | 25212104 |
| hematopoietic stem cell migration to bone marrow, MYELODYSPLASTIC SYNDROME, Cytopenia | Stem Cell Exhaustion | Myelodysplastic syndromes are a heterogeneous group of clonal bone marrow hematopoietic stem cell disorders characterized by ineffective hematopoiesis and peripheral cytopenias. | 25216221 |
| Infiltration | Stem Cell Exhaustion | While T3 were mainly composed by platelets and fibrin(ogen), T6 were characterized by a reduced platelet content, increased leucocytes infiltration (including monocytes, neutrophils, T-cells, and B-cells), and appearance of undifferentiated progenitor cells. | 25217443 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Myelodysplastic syndromes are clonal disorders of stem cells, characterized by heterogeneous clinical presentation. | 25217620 |
| Palmar-plantar erythrodysesthesia syndrome, Multiple Myeloma | Stem Cell Exhaustion | GWAS of 972 autologous stem cell recipients with multiple myeloma identifies 11 genetic variants associated with chemotherapy-induced oral mucositis. | 25218607 |
| Malignant Neoplasms, Multiple Myeloma, Pregnancy Complications, Infectious, Gastrointestinal mucositis, Usual Severity Pain, Morular Metaplasia of the Endometrium | Stem Cell Exhaustion | High-dose chemotherapy and autologous stem cell transplant (ASCT) to treat multiple myeloma (MM) and other cancers carries the risk of oral mucositis (OM) with sequelae including impaired nutritional and fluid intake, pain, and infectious complications. | 25218607 |
| Neoplasms, Porphyromonas gingivalis | Stem Cell Exhaustion | The GroEL protein of Porphyromonas gingivalis accelerates tumor growth by enhancing endothelial progenitor cell function and neovascularization. | 25220060 |
| Carcinoma | Stem Cell Exhaustion | Here, we investigated the effects of P. gingivalis GroEL on neovasculogenesis in C26 carcinoma cell-carrying BALB/c mice and chick eggs in vivo as well as its effect on human endothelial progenitor cells (EPC) in vitro. | 25220060 |
| PAFAH1B1 wt Allele, Acute leukemia | Stem Cell Exhaustion | It is well accepted that genomic instability in dysplastic hematopoietic stem/progenitor cells (HSPC) drives the evolution of MDS to acute leukemia. | 25220590 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Impact of early remission by induction therapy on allogeneic stem cell transplantation for acute myeloid leukemia with an intermediate-risk karyotype in first complete remission. | 25220715 |
| GDC Disease Response Terminology, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Here, we retrospectively examined the prognostic impact of early remission (ER) vs. delayed remission (DR) in a cohort of 132 AML patients with an intermediate-risk karyotype undergoing allogeneic stem cell transplantation (alloSCT) in first complete remission (CR1). | 25220715 |
| leukemia | Stem Cell Exhaustion | To the best of our knowledge, this is the first report of IHA that was not induced by intensive chemotherapy, stem cell transplantation, or asparaginase therapy in a patient with newly diagnosed leukemia, but developed during an initial treatment with a steroid. | 25222063 |
| Lymphadenopathy, Lymphoproliferative Disorders | Stem Cell Exhaustion | Manifestations of fulminant CD8 T-cell post-transplant lymphoproliferative disorder following the administration of rituximab for lymphadenopathy with a high level of Epstein-Barr Virus (EBV) replication after allogeneic hematopoietic stem cell transplantation. | 25224199 |
| Aplastic Anemia | Stem Cell Exhaustion | We herein report the case of a 22-year-old woman with severe aplastic anemia who underwent allogeneic hematopoietic stem cell transplantation (HSCT). | 25224199 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Steroid-refractory graft-versus-host disease (GVHD) is a major and often fatal complication after allogeneic stem-cell transplantation (alloSCT). | 25225421 |
| Chronic Obstructive Airway Disease, Pulmonary Hypertension | Stem Cell Exhaustion | Changes of Number and Function of Late Endothelial Progenitor Cells in Peripheral Blood of COPD Patients Combined with Pulmonary Hypertension. | 25226359 |
| Chronic Obstructive Airway Disease, Pulmonary Hypertension | Stem Cell Exhaustion | Objective The objective of this study was to investigate the changes of number and function of late endothelial progenitor cells (EPCs) in peripheral blood of chronic obstructive pulmonary disease (COPD) patients combined with pulmonary hypertension. | 25226359 |
| gastrointestinal | Stem Cell Exhaustion | Patients undergoing hematopoietic stem cell transplant (HSCT) can experience gastrointestinal (GI) side effects as a complication of the treatment. | 25227122 |
| Precursor cell lymphoblastic lymphoma, Lymphoid neoplasm, Dendritic Cells | Stem Cell Exhaustion | Unique composite hematolymphoid tumor consisting of a pro-T lymphoblastic lymphoma and an indeterminate dendritic cell tumor: evidence for divergent common progenitor cell differentiation. | 25228298 |
| Lymphoid neoplasm | Stem Cell Exhaustion | In the last years, evidence for transdifferentiation from one cell lineage to another or divergent common progenitor cell differentiation has accumulated, mainly based on composite hematolymphoid tumors, sharing common genetic abnormalities. | 25228298 |
| teratologic, Lymphoid neoplasm | Stem Cell Exhaustion | The synchronous appearance of two distinct uncommon hematolymphoid tumors in the same patient, recurrent at three different anatomic locations, with an identifiable common genetic denominator, namely +21, but also with unique genetic anomalies in the pro-T LBL raises the hypothesis of a divergent common progenitor cell differentiation. | 25228298 |
| Aggressive Adult Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Clinical outcomes of a novel combination of lenalidomide and rituximab followed by stem cell transplantation for relapsed/refractory aggressive B-cell non-hodgkin lymphoma. | 25228589 |
| Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | We retrospectively compared outcomes of patients with relapsed/refractory non-Hodgkin lymphoma (NHL) who underwent stem cell transplantation (SCT) with stable disease or better following a novel combination of lenalidomide and rituximab (LR) treatment and did not undergo SCT in a phase I/II clinical trial. | 25228589 |
| Specialty Type - cancer | Stem Cell Exhaustion | Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell. | 25228591 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cells (CSCs) retain the capacity to propagate themselves through self-renewal and to produce heterogeneous lineages of cancer cells constituting the tumor. | 25228591 |
| Lung Diseases, Interstitial, PICALM gene | Stem Cell Exhaustion | Preoperatively, interstitial lung disease was more common in LDLLT patients than in CLT patients (47.6 vs 24.3%, P = 0.048); prior haematopoietic stem cell transplantation was performed more often in LDLLT patients than in CLT patients (33.3 vs 13.5%, P = 0.040) and there were more steroid-dependent LDLLT patients than CLT patients (64.3 vs 29.7%, P = 0.0022). | 25228745 |
| Steroid-Refractory Pneumonitis | Stem Cell Exhaustion | Etanercept for steroid-refractory acute graft versus host disease following allogeneic hematopoietic stem cell transplantation. | 25228839 |
| Graft-vs-Host Disease, Steroid-Refractory Pneumonitis | Stem Cell Exhaustion | The treatment for steroid-refractory acute graft versus host disease (GVHD) after allogeneic stem cell transplantation (allo-SCT) needs to be standardized. | 25228839 |
| Neoplasms | Stem Cell Exhaustion | Cells with stem cell-like properties have been identified in tumors from a variety of origins, but to our knowledge there are yet no reports on tumor-related stem cells in the human upper respiratory tract. | 25229469 |
| Neoplasms | Stem Cell Exhaustion | These cells, designated as MEi (mesenchymal stem cell-like mucoepidermoid tumor) cells, could be differentiated towards mesenchymal lineages both with and without induction, and formed spheroids in vitro. | 25229469 |
| Angina Pectoris | Stem Cell Exhaustion | Selected CD133+ progenitor cells to promote angiogenesis in patients with refractory angina: final results of the PROGENITOR randomized trial. | 25231095 |
| Acute lymphocytic leukemia, Failure, Toxic effect, BCR gene | Stem Cell Exhaustion | We retrospectively studied toxicity and outcome of 71 paediatric patients with acute lymphoblastic leukaemia (ALL) undergoing haematopoietic stem cell transplantation (HSCT) following treosulfan-based conditioning aiming to identify risk factors for treatment failure and dose-depending outcome differences. | 25231927 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | The National Marrow Donor Program/Be The Match has collected HLA typing from CLL patients in need of allogeneic hematopoietic stem cell transplant and has recruited millions of volunteers to potentially donate hematopoietic stem cells. | 25232063 |
| Specialty Type - cancer | Stem Cell Exhaustion | Exploring the Cancer Experiences of Young Adults in the Context of Stem Cell Transplantation. | 25232959 |
| Malignant Neoplasms | Stem Cell Exhaustion | Stem cell transplantation (SCT), a treatment modality for a variety of YA malignancies, often requires prolonged hospitalization and immune-compromising treatment regimens. | 25232959 |
| Hepatosplenic T-cell lymphoma, Lymphoma | Stem Cell Exhaustion | Allogeneic and autologous stem cell transplantation for hepatosplenic T-cell lymphoma: a retrospective study of the EBMT Lymphoma Working Party. | 25234166 |
| Peripheral T-Cell Lymphoma, Hepatosplenic T-cell lymphoma | Stem Cell Exhaustion | The objective of this registry study was to analyse the outcome of patients who underwent allogeneic or autologous haematopoietic stem cell transplantation (HSCT) for hepatosplenic T-cell lymphoma (HSTL), a rare and extremely aggressive peripheral T-cell lymphoma subtype. | 25234166 |
| Cessation of life, Multiple Organ Failure | Stem Cell Exhaustion | The main causes of death were complications from haematopoietic stem-cell transplantation and multiorgan failure. | 25234411 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | The efficacy and safety of plerixafor, an antagonist of the CXCR4 receptor, in combination with G-CSF has been demonstrated in patients suffering from Iymphoma and multiple myeloma (MM) eligible for autologous haematopoietic stem cell collection. | 25236359 |
| Hodgkin Disease, Multiple Myeloma, Childhood Non-Hodgkin Lymphoma, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | This was a phase 1/2, randomized, observer-blind, placebo-controlled study in adults with multiple myeloma, non-Hodgkin lymphoma (B- or T-cell), Hodgkin lymphoma, or acute myeloid leukemia who had undergone autologous hematopoietic stem-cell transplant 50 to 70 days earlier. | 25237196 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Comparison of umbilical cord blood allogeneic stem cell transplantation vs. auto-SCT for adult acute myeloid leukemia patients in second complete remission at transplant: a retrospective study on behalf of the SFGM-TC. | 25238651 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | This retrospective study considered the outcomes of 181 patients with acute myeloid leukemia (AML) transplanted in second complete remission (CR2) between January 2005 and April 2012 and who received either a myeloablative autologous stem cell transplant (Auto-SCT; n = 82; median age: 48 years; median follow-up: 45 months) or an umbilical cord blood (UCB) allogeneic SCT (n = 99, median age: 46 years; median follow-up: 36 months; conditioning regimens: myeloablative n = 21, reduced n = 78; single unit n = 37, double units n = 62). | 25238651 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Phase I trial of maintenance sorafenib after allogeneic hematopoietic stem cell transplantation for fms-like tyrosine kinase 3 internal tandem duplication acute myeloid leukemia. | 25239228 |
| FLT3 Internal Tandem Duplication, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutation is associated with a high relapse rate for patients with acute myeloid leukemia (AML) even after allogeneic hematopoietic stem cell transplantation (HSCT). | 25239228 |
| Lupus Erythematosus | Stem Cell Exhaustion | High level of reactive oxygen species impaired mesenchymal stem cell migration via overpolymerization of F-actin cytoskeleton in systemic lupus erythematosus. | 25239279 |
| Lupus Erythematosus, Encephalitis, St. Louis | Stem Cell Exhaustion | Some lines of evidence have demonstrated abnormalities of bone marrow mesenchymal stem cells (MSCs) in systemic lupus erythematosus (SLE) patients, characterized by defective phenotype of MSCs and slower growth with enhanced apoptosis and senescence. | 25239279 |
| Stem Cell Factor | Stem Cell Exhaustion | Plasma levels of vascular endothelial growth factor A (VEGF-A), thrombospondin-1 (TSP-1) and stem cell factor (SCF) were determined by Elisa. | 25239280 |
| Specialty Type - cancer | Stem Cell Exhaustion | All except two had underlying cancer, and 47 (35.6%) also received a stem cell transplant. | 25239419 |
| Lymphoma, Follicular | Stem Cell Exhaustion | PET/CT before autologous stem cell transplantation predicts outcome in refractory/relapsed follicular lymphoma. | 25239490 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Salvage of young patients with follicular lymphoma (FL) after R-CHOP includes salvage immunochemotherapy followed by autologous stem cell transplantation (ASCT). | 25239490 |
| Hepatotoxicity | Stem Cell Exhaustion | Possible amlodipine-induced hepatotoxicity after stem cell transplant. | 25239629 |
| Hepatotoxicity | Stem Cell Exhaustion | Allogeneic stem cell transplant patients are often prescribed many medications that carry the risk of hepatotoxicity. | 25239629 |
| Specialty Type - cancer, Adenocarcinoma of pancreas | Stem Cell Exhaustion | Immunohistochemical analysis of cancer stem cell markers in pancreatic adenocarcinoma patients after neoadjuvant chemoradiotherapy. | 25240521 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells (CSCs) have been reported to play an important role in chemoradiation resistance. | 25240521 |
| Intrahepatic Route of Drug Administration, Hepatitis C | Stem Cell Exhaustion | Analysis of the intrahepatic ductular reaction and progenitor cell responses in hepatitis C virus recurrence after liver transplantation. | 25241637 |
| GDC Disease Response Terminology, Fibrosis Assessment, Hepatitis C | Stem Cell Exhaustion | In livers with HCV infections in the non-LT setting, there is a significant relationship between the development of structures known as the ductular reaction (DR), hepatic progenitor cells (HPCs), and fibrosis. | 25241637 |
| Laryngeal Squamous Cell Carcinoma | Stem Cell Exhaustion | Stem cell markers OCT4 and nestin in laryngeal squamous cell carcinoma and their relation to survivin expression. | 25242024 |
| Laryngeal Squamous Cell Carcinoma | Stem Cell Exhaustion | We explored the expression of the stem cell markers OCT4 and nestin in laryngeal squamous cell carcinoma (LSCC) and investigated their relationship to survivin expression. | 25242024 |
| Hematopoietic stem cells, Haploinsufficiency | Stem Cell Exhaustion | We generated a murine model with conditional inactivation of Csnk1a1 and found that Csnk1a1 haploinsufficiency induces hematopoietic stem cell expansion and a competitive repopulation advantage, whereas homozygous deletion induces hematopoietic stem cell failure. | 25242043 |
| Muscular Dystrophy, Sarcopenia | Stem Cell Exhaustion | Finally, clinical situations are outlined where there is a need to enhance skeletal muscle regeneration: these include acute and chronic injuries or transplantation with bioengineering to form new muscles, therapeutic approaches to muscular dystrophies, and comment on proposed stem cell therapies to reduce age-related loss of muscle mass and function. | 25242742 |
| Graft-vs-Host Disease, Exanthema | Stem Cell Exhaustion | Skin biopsy was done and showed interface lymphocytic infiltrate that are largely centered on the dermal-epidermal junction, is consistent with GVHD (this pattern of rash distribution is unique and different from the rash of GVHD after hematopoietic stem cell transplant, which is confined to palms of the hands and soles of the feet; Fig 1). | 25242798 |
| Spinal Cord Ischemia | Stem Cell Exhaustion | Our findings identify SIRT1 as regulator of hypoxia-induced response in hMSCs and may contribute to the development of new therapeutic strategies to improve regenerative properties of mesenchymal stem cells in ischemic disorders through SIRT1 modulation. | 25243179 |
| Graft-vs-Host Disease, Liver Failure | Stem Cell Exhaustion | The patient received an allo-unrelated peripheral blood stem-cell transplantation and expired due to graft-versus-host disease following liver failure. | 25243347 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation provides the best chance of long-term survival for patients with AML, but is associated with an unpredictable risk of treatment-related mortality. | 25243624 |
| Paroxysmal nocturnal hemoglobinuria | Stem Cell Exhaustion | Together, our data indicate that in addition to PIGA mutations, accessory genetic events are frequent in PNH, suggesting a stepwise clonal evolution derived from a singular stem cell clone. | 25244093 |
| Thrombophilia, Hemolysis (biological function), Bone marrow hypocellularity, Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0 | Stem Cell Exhaustion | Paroxysmal nocturnal hemoglobinuria (PNH) is a nonmalignant clonal disease of hematopoietic stem cells that is associated with hemolysis, marrow failure, and thrombophilia. | 25244093 |
| Graft-vs-Host Disease, Acute GVH disease, Inflammatory disorder | Stem Cell Exhaustion | Myeloid-derived suppressor cells (MDSCs) are powerful immunomodulatory cells that in mice play a role in infectious and inflammatory disorders, including acute graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation. | 25246295 |
| Acute GVH disease | Stem Cell Exhaustion | Graft monocytic myeloid-derived suppressor cell content predicts the risk of acute graft-versus-host disease after allogeneic transplantation of granulocyte colony-stimulating factor-mobilized peripheral blood stem cells. | 25246295 |
| Amyloidosis | Stem Cell Exhaustion | We report a retrospective evaluation of the clinical outcome of treatment with bortezomib, melphalan, and prednisolone (VMP) as first-line chemotherapy in patients with AL amyloidosis who were ineligible for autologous stem cell transplant. | 25248716 |
| Inflammation, Multiple Myeloma | Stem Cell Exhaustion | Longitudinal analysis of patient-reported symptoms post-autologous stem cell transplant and their relationship to inflammation in patients with multiple myeloma. | 25248883 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | After autologous stem cell transplant (AuSCT), patients with multiple myeloma (MM) may receive lenalidomide maintenance therapy. | 25248883 |
| Hypoxia | Stem Cell Exhaustion | TRIM62 loss was associated with altered expression of proteins involved in leukemia stem cell homeostasis (b-catenin and Notch), cell motility, and adhesion (integrin-b3, ras-related C3 botulinum toxin substrate [RAC], and fibronectin), hypoxia (Hypoxia-inducible factor 1-alpha [HIF1a], egl-9 family hypoxia-inducible factor 1 [Egln1], and glucose-regulated protein, 78 kDa [GRP78]), and apoptosis (B-cell lymphoma-extra large (BclXL) and caspase 9). | 25248926 |
| Diabetes, Metabolic Diseases | Stem Cell Exhaustion | Hyperglycaemic milieu as well as other metabolic disorders linked to diabetes may have an influence on endogenous stem cell properties. | 25251698 |
| diabetic | Stem Cell Exhaustion | The present study investigated the feasibility of autologous stem cell therapy in diabetic patients. | 25251698 |
| Diabetes | Stem Cell Exhaustion | Adipose tissue is an abundant source of autologous adult stem cells that may bring new therapeutic perspectives on the treatment of diabetes and its complications. | 25251698 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Aldehyde dehydrogenase 1 family member A1 (ALDH1A1) is a cancer stem cell marker, and its expression correlates with prognosis in a number of malignancies. | 25253129 |
| Virus Diseases, Memory | Stem Cell Exhaustion | T(SCM) constitute a recently identified lymphocyte subset with stem cell-like qualities, including the ability to generate other memory T cell subtypes, and are therefore likely to play an important role in controlling viral infection. | 25253339 |
| Healthcare Encounters Domain | Stem Cell Exhaustion | In HO, mesenchymal stem cells (MSCs) are inappropriately activated to undergo osteogenic differentiation. | 25253675 |
| Osteoporosis | Stem Cell Exhaustion | Bone marrow-derived mesenchymal stem cells (BMMSCs) from the patients suffering from age-related osteoporosis were found to have numerous degeneration, such as decreased growth rate, impaired capacity of differentiating into local tissue, and repressed telomerase activity. | 25257163 |
| Extramedullary Plasmacytoma, Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | The prognostic impact of extramedullary plasmacytomas (EMPs) on newly diagnosed symptomatic multiple myeloma (MM) was evaluated in the context of treatment approach including autologous stem cell transplantation (ASCT) and chemotherapy alone. | 25257340 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Prognostic implication of gene mutations on overall survival in the adult acute myeloid leukemia patients receiving or not receiving allogeneic hematopoietic stem cell transplantations. | 25260824 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Allogeneic stem cell transplantation for patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) has been performed primarily with an HLA-matched donor. | 25263628 |
| Cessation of life | Stem Cell Exhaustion | Risk factor for death in hematopoietic stem cell transplantation: are biomarkers useful to foresee the prognosis in this population of patients? | 25263811 |
| Pregnancy Complications, Infectious | Stem Cell Exhaustion | The morbidity and mortality in hematopoietic stem cell transplantation (HSCT) occur due to infectious complications and constitute the major clinical problems in HSCT recipients. | 25263811 |
| Myeloma cell | Stem Cell Exhaustion | Among plasma cell myeloma (PCM) patients, gene expression profiling (GEP)-based molecular classification has proven to be an independent predictor of survival, after autologous stem cell transplantation. | 25265432 |
| Toxic effect | Stem Cell Exhaustion | We anticipate that such an approach might allow patients with high-risk immunoprofiles to be considered for other potential novel therapeutic agents, potentially sparing some patients the toxicity of stem cell transplant. | 25265432 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Thus CD146 might be a new cell surface marker for cartilage progenitor cell population in the late-stage osteoarthritis. | 25266708 |
| Multiple Myeloma, Hypertension, CTCAE | Stem Cell Exhaustion | A 62 year-old Caucasian man with hypertension and a 4-year history of multiple myeloma, had been previously treated with lenalidomide, bortezomib and two autologous hematopoietic stem cell transplants. | 25267524 |
| Kidney Failure, Acute, Septic Shock | Stem Cell Exhaustion | After the second hematopoietic stem cell transplant, he developed acute kidney injury secondary to septic shock and required dialysis for 4 weeks. | 25267524 |
| Multiple Myeloma | Stem Cell Exhaustion | Seventeen months after the second hematopoietic stem cell transplant, he was initiated on carfilzomib for relapse of multiple myeloma. | 25267524 |
| Aggressive Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Randomized comparison of gemcitabine, dexamethasone, and cisplatin versus dexamethasone, cytarabine, and cisplatin chemotherapy before autologous stem-cell transplantation for relapsed and refractory aggressive lymphomas: NCIC-CTG LY.12. | 25267740 |
| Aggressive Non-Hodgkin Lymphoma | Stem Cell Exhaustion | For patients with relapsed or refractory aggressive lymphoma, we hypothesized that gemcitabine-based therapy before autologous stem-cell transplantation (ASCT) is as effective as and less toxic than standard treatment. | 25267740 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Estrogen receptor, progesterone receptor, interleukin-6 and interleukin-8 are variable in breast cancer and benign stem/progenitor cell populations. | 25269750 |
| Childhood Breast Carcinoma, Neoplasms | Stem Cell Exhaustion | Breast cancer stem/progenitor cells (BCSCs) initiate tumors, but expression of estrogen (ER) or progesterone receptors (PR) and response to tamoxifen is unknown. | 25269750 |
| Neoplasms | Stem Cell Exhaustion | On average, BCSCs expressed 10-106 fold less ERa mRNA and 10-103 fold more ERb than tumors or benign stem/progenitor cells (SC). | 25269750 |
| Liver carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Regulatory MiR-148a-ACVR1/BMP circuit defines a cancer stem cell-like aggressive subtype of hepatocellular carcinoma. | 25271001 |
| Specialty Type - cancer | Stem Cell Exhaustion | The subtype characterized by a cancer stem cell-like signature was clinically aggressive and associated with poor survival. | 25271001 |
| Hollings Cancer Center | Stem Cell Exhaustion | We identified a clinically aggressive stem cell-like subtype of HCC that is characterized by an miR-148a-ACVR1-BMP-Wnt circuit. | 25271001 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | Oral mucositis is a chief complication in patients undergoing hematopoietic stem cell transplantation (HSCT). | 25271965 |
| Multiple Myeloma | Stem Cell Exhaustion | 18 FDG-PET/CT for prognostic stratification of patients with multiple myeloma relapse after stem cell transplantation. | 25277179 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | The aim of this study was to investigate the prognostic value of 18F-fluoro-deoxyglucose positron emission tomography-computed tomography (18F-FDG-PET/CT) in 37 patients with a history of multiple myeloma (MM) and suspected or confirmed recurrence after stem cell transplantation (SCT). | 25277179 |
| Adenocarcinoma of pancreas | Stem Cell Exhaustion | The hedgehog (HH) signaling pathway is a key regulator in tumorigenesis of pancreatic adenocarcinoma and is upregulated in pancreatic adenocarcinoma cancer stem cells (CSCs). | 25278454 |
| Multiple Myeloma | Stem Cell Exhaustion | Efficacy of vinorelbine plus granulocyte colony-stimulation factor for CD34+ hematopoietic progenitor cell mobilization in patients with multiple myeloma. | 25278456 |
| Multiple Myeloma | Stem Cell Exhaustion | We aimed to assess the efficacy of vinorelbine plus granulocyte colony-stimulating factor (G-CSF) for chemo-mobilization of CD34(+) hematopoietic progenitor cells (HPC) in patients with multiple myeloma and to identify adverse risk factors for successful mobilization. | 25278456 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | The BORIS-positive cells isolated using BORIS-molecular beacon, expressed higher telomerase hTERT, stem cell (NANOG, OCT4, SOX2) and cancer stem cell marker genes (CD44 and ALDH1) compared to the BORIS-negative tumor cells. | 25279549 |
| Avascular Necrosis, CTCAE | Stem Cell Exhaustion | Complete resolution of avascular necrosis of the human femoral head treated with adipose tissue-derived stem cells and platelet-rich plasma. | 25281062 |
| Avascular necrosis, Avascular Necrosis, CTCAE | Stem Cell Exhaustion | We report a case of a 43-year-old man with early stage (stage 1) avascular necrosis (AVN) of the femoral head treated with adipose tissue-derived stem cells (ASCs) and platelet-rich plasma (PRP). | 25281062 |
| Glioma, Specialty Type - cancer | Stem Cell Exhaustion | The prognostic value of clinical factors and cancer stem cell-related markers in gliomas. | 25283629 |
| Glioblastoma Multiforme Pathway, Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | The same characteristics were identified in cancer cells, and recently a major part of the glioma research has focused on the cancer stem cell (CSC) hypothesis, suggesting that only CSCs posses the ability of initiating new tumours. | 25283629 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | Treatment of MDS comprised allogeneic stem cell transplant in eight patients (median survival, 219 days; one patient alive at 624 days) and a hypomethylating agent in 21 patients (response of stable or better in five patients). | 25284489 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | We sought to determine whether the more intensive salvage chemotherapy approach used in Southern Alberta (SAB) compared to the conventional dose salvage approach used in Northern Alberta (NAB) affects the rates of autologous stem cell transplant (ASCT) and survival in patients with relapsed DLBCL. | 25284495 |
| Muscle, Smooth, Vascular | Stem Cell Exhaustion | Here, we leverage human pluripotent stem cells to generate vascular smooth muscle cells (SMCs) from neural crest progenitors, recapitulating brain-vasculature-specific attributes of Ab metabolism. | 25284792 |
| Neoplasms | Stem Cell Exhaustion | These tumours have a polyphenotypic immunophentype that favours a derivation from uterine mesenchymal stem cells. | 25291872 |
| Multiple Myeloma | Stem Cell Exhaustion | Cyclophosphamide-based hematopoietic stem cell mobilization before autologous stem cell transplantation in newly diagnosed multiple myeloma. | 25293363 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | High-dose cyclophosphamide (Cy) is frequently employed for peripheral blood mobilization of hematopoietic stem cells before high-dose chemotherapy with autologous stem cell transplantation (ASCT) in multiple myeloma (MM). | 25293363 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Live birth after single embryo transfer of autologous cryopreserved oocytes from a patient with myelodysplastic syndrome who underwent allogenic peripheral blood stem cell transplantation. | 25294099 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | We report a live birth after single embryo transfer derived from autologous cryopreserved oocytes of a patient with myelodysplastic syndrome who had undergone allogenic peripheral blood stem cell transplantation (PBSCT). | 25294099 |
| Extramedullary | Stem Cell Exhaustion | Clinical and pathologic analysis of extramedullary tumors after hematopoietic stem cell transplantation. | 25294373 |
| Extramedullary | Stem Cell Exhaustion | Clinical and pathologic analyses of 41 extramedullary biopsy/resection specimens of extramedullary tumors (EMTs) after hematopoietic stem cell transplantation (HSCT) were performed. | 25294373 |
| Specialty Type - cancer, Lymphoma, Multiple Myeloma, leukemia | Stem Cell Exhaustion | Between September 2013 and January 2014, 20 hematologic oncologists from the Dana-Farber/Harvard Cancer Center participated in four focus groups regarding EOL care for leukemia, lymphoma, multiple myeloma, and hematopoietic stem-cell transplantation. | 25294393 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Activation of the Hippo transducer TAZ is emerging as a novel oncogenic route in breast cancer and it has been associated with breast cancer stem cells. | 25294813 |
| Hypertensive (finding) | Stem Cell Exhaustion | Quantitative and functional characteristics of endothelial progenitor cells in newly diagnosed hypertensive patients. | 25296717 |
| Fatigue, Depression, CTCAE, Anxiety Disorders | Stem Cell Exhaustion | Health-related quality of life (HRQoL) is often substantially reduced among individuals who have undergone hematopoietic stem cell transplantation (HSCT), and incidences of depression, fatigue, and anxiety are elevated. | 25297466 |
| Chronic granulomatous disease | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplant for high-risk adult patients with chronic granulomatous disease: first case report from Iran. | 25299376 |
| Chronic granulomatous disease | Stem Cell Exhaustion | We describe the successful hematopoietic stem cell transplant of a 22-year-old patient with chronic granulomatous disease at our center. | 25299376 |
| Chronic granulomatous disease | Stem Cell Exhaustion | Our case was a relatively old male patient compared with other patients having the diagnosis of chronic granulomatous disease who underwent hematopoietic stem cell transplant. | 25299376 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | At the time of this writing, the patient is alive and well with no serious complication and without any evidence of graft-versus-host disease or rejection 12 months after stem cell transplant. | 25299376 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Influence of insulin and glargine on outgrowth and number of circulating endothelial progenitor cells in type 2 diabetes patients: a partially double-blind, randomized, three-arm unicenter study. | 25300286 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | A well-tolerated regimen of 800 cGy TBI-fludarabine-busulfan-ATG for reliable engraftment after unmanipulated haploidentical peripheral blood stem cell transplantation in adult patients with acute myeloid leukemia. | 25300871 |
| peripheral blood, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Eighty adult patients with acute myeloid leukemia (AML) received peripheral blood T cell-replete HLA haploidentical hematopoietic stem cell transplantation (haplo-HSCT). | 25300871 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We suggest the strategy of fractionated 800 cGy TBI-based conditioning with unmanipulated peripheral blood stem cell grafts seems feasible with favorable outcomes for adult patients with AML undergoing haplo-HSCT in CR. | 25300871 |
| Myeloid Leukemia, Chronic, B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1, BCR gene | Stem Cell Exhaustion | Despite the successes of tyrosine kinase inhibitors (TKIs) in improving outcomes in patients with chronic myeloid leukemia (CML) and Philadelphia-positive acute lymphoblastic leukemia (Ph + ALL), allogeneic hematopoietic stem cell transplantation (HSCT) continues to be an important and potentially curative option for selected patients with either disease. | 25300870 |
| Sex Characteristics | Stem Cell Exhaustion | Sexual dimorphism in epigenomic responses of stem cells to extreme fetal growth. | 25300954 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Haploidentical peripheral blood stem cell infusion in combination with chemotherapy for acute myeloid leukaemia in elderly patients. | 25302724 |
| Toxic effect, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Two elderly AML patients treated with infusion of family-derived partially human leukocyte antigen (HLA)-matched peripheral blood stem cells following each cycle of chemotherapy entered morphological complete remission without graft versus host disease or major toxicity. | 25302724 |
| Multiple Myeloma | Stem Cell Exhaustion | Thalidomide-prednisone maintenance following autologous stem cell transplant for multiple myeloma: effect on thrombin generation and procoagulant markers in NCIC CTG MY.10. | 25302852 |
| Specialty Type - cancer, vinyltriethoxysilane | Stem Cell Exhaustion | The National Cancer Institute of Canada Clinical Trials Group MY.10 phase III clinical trial compared thalidomide-prednisone to observation for 332 patients with MM post-autologous stem cell transplantation (ASCT), with a primary endpoint of overall survival and various secondary endpoints including the incidence of VTE. | 25302852 |
| Secondary Neoplasm | Stem Cell Exhaustion | Moreover, epithelial-mesenchymal transition (EMT) and stem cell features are major mechanisms for metastasis. | 25303055 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Using a triple fluorescence technique, the expression of EMT (N-cadherin) and stem cell markers (CD133) was analyzed in CTCs detected via cytokeratin in blood samples from 26 metastatic breast cancer patients. | 25303055 |
| Kidney Failure, Chronic, Rheumatoid Arthritis, HIV Infections, Immunocompromised Host | Stem Cell Exhaustion | Immunocompromised patients with HIV infection, chronic renal failure, rheumatoid arthritis, solid-organ or stem-cell transplantation, and healthy control subjects were evaluated head-to-head by the TST, QuantiFERON-TB-Gold in-tube test (ELISA), and T-SPOT.TB test (enzyme-linked immunospot) at 17 centers in 11 European countries. | 25303140 |
| Kidney Failure, Chronic, Rheumatoid Arthritis, HIV Infections | Stem Cell Exhaustion | Frequencies of positive test results varied from 8.7 to 15.9% in HIV infection (n = 768), 25.3 to 30.6% in chronic renal failure (n = 270), 25.0% to 37.2% in rheumatoid arthritis (n = 199), 9.0 to 20.0% in solid-organ transplant recipients (n = 197), 0% to 5.8% in stem-cell transplant recipients (n = 103), and 11.2 to 15.2% in immunocompetent control subjects (n = 211). | 25303140 |
| Ischemia, Diabetic Foot | Stem Cell Exhaustion | Comparison of the effect of stem cell therapy and percutaneous transluminal angioplasty on diabetic foot disease in patients with critical limb ischemia. | 25304666 |
| CLU protein, human, Ischemia, Diabetic Foot | Stem Cell Exhaustion | The aim of our study was to compare the effect of autologous stem cell therapy (SCT) and percutaneous transluminal angioplasty (PTA) on diabetic foot disease (DFD) in patients with critical limb ischemia (CLI). | 25304666 |
| CLU protein, human | Stem Cell Exhaustion | Thirty-one patients with DFD and CLI treated by autologous stem cells and 30 patients treated by PTA were included in the study; 23 patients with the same inclusion criteria who could not undergo PTA or SCT formed the control group. | 25304666 |
| Ischemic stroke | Stem Cell Exhaustion | Reparative therapy for acute ischemic stroke with allogeneic mesenchymal stem cells from adipose tissue: a safety assessment: a phase II randomized, double-blind, placebo-controlled, single-center, pilot clinical trial. | 25304723 |
| Cerebrovascular accident | Stem Cell Exhaustion | Few studies have evaluated the possible beneficial effect of the administration of stem cells in the early stages of stroke. | 25304723 |
| Acute Cerebrovascular Accidents | Stem Cell Exhaustion | Intravenous administration of allogeneic mesenchymal stem cells (MSCs) from adipose tissue in patients with acute stroke could be a safe therapy for promoting neurovascular unit repair, consequently supporting better functional recovery. | 25304723 |
| Blood Vessel | Stem Cell Exhaustion | This was measured by prevalence of endothelial progenitor cells (EPCs), which are bone marrow-derived cells that home preferentially to sites of vascular damage. | 25306212 |
| Bacterial Infections | Stem Cell Exhaustion | In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. | 25307862 |
| Neoplasms | Stem Cell Exhaustion | We cultured cells from healthy gastric tissues, single-sorted stem cells, or tumor tissues. | 25307862 |
| NTRK1 wt Allele | Stem Cell Exhaustion | The most widely accepted hypotheses considering co-occurrence of MTC and PTC are stem cell theory, collision effect theory and hostage theory. | 25308015 |
| Neoplasms | Stem Cell Exhaustion | In conclusion, co-expression of thyroglobulin, synaptophysin and chromogranin by the papillary component of mixed tumor seems to support stem cell theory in our first case, whereas positive staining for calcitonin but not for thyroglobulin in the medullary component of the tumor along with separation of these two tumors from each other by a normal thyroid tissue seem to indicates the likelihood of collision effect theory in our second case. | 25308015 |
| Malignant Neoplasms | Stem Cell Exhaustion | Results In total, 73% of patients had high-grade malignancy, 47.6% received intensive chemotherapy before admission, and 30% underwent hematologic stem cell transplantation procedure. | 25310461 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The explosion of new knowledge regarding the AML genome has yet to be translated into therapeutic benefit, but analysis of specific molecular features in AML samples has enabled the field to more accurately parse out prognosis and assign appropriate therapies (eg, chemotherapy vs allogeneic stem cell transplantation) for groups of patients. | 25311744 |
| Hypertrophy | Stem Cell Exhaustion | More specifically, we focused on the myogenic stem cell population, the satellite cell (SC) as a potential mediator of hypertrophy. | 25313863 |
| Hematological Disease | Stem Cell Exhaustion | In 2008-2012, the Hematology Research Center, Ministry of Health of the Russian Federation, examined 203 patients with blood system diseases who needed allogeneic hematopoietic stem cell transplantation (allo-HSCT) and their 386 blood relatives. | 25314775 |
| Hematological Disease | Stem Cell Exhaustion | These registries increase the chance to find a HLA-compatible unrelated donor for a short time for a patient with blood disease who has an indication for hematopoietic stem cell transplantation. | 25314775 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Our results suggested that the interaction between OACs and ADSCs is highly dependent on cell distribution in 3D and soluble factors, which should be taken into consideration when designing stem cell-based therapy for treating OA patients. | 25315023 |
| Cartilage Diseases, Degenerative polyarthritis | Stem Cell Exhaustion | Stem cells hold great promise for treating cartilage degenerative diseases such as osteoarthritis (OA). | 25315023 |
| NGFR gene | Stem Cell Exhaustion | In addition, tomato feeding significantly reduced expression of genes associated with stem cell features, Aldh1a and Ly6a, whereas lycopene feeding significantly reduced expression of neuroendocrine differentiation-related genes, Ngfr and Syp. | 25315431 |
| Prostate carcinoma | Stem Cell Exhaustion | Future studies on androgen signaling/metabolism, stem cell features, and neuroendocrine differentiation pathways may elucidate the mechanisms by which dietary tomato and lycopene impact prostate cancer risk. | 25315431 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | Patients >=aged 60 years with relapsed/refractory DLBCL, not candidates for autologous stem cell transplantation, were treated R-CVEP [R 375 mg/m(2) intravenously (IV), day 1; C 600 mg/m(2) IV days 1, 8: E 70 mg/m(2) IV day 1, 140 mg/m(2) days 2, 3 orally (PO); V (300 vs. 400 mg) PO and P 60 mg/m(2) PO days 1-10] every 28 d for six cycles. | 25316653 |
| TSPYL2 gene, Primary cutaneous lymphoma | Stem Cell Exhaustion | Brentuximab is a well-tolerated, promising new treatment option for advanced CTCL that can be integrated in an allogeneic stem cell transplantation plan by selectively depleting malignant CD30+ cutaneous lymphoma cells. | 25317818 |
| Lymphoproliferative Disorders | Stem Cell Exhaustion | Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disorder (EBV-PTLD) is a complication of hematopoietic stem cell transplantation (HSCT). | 25318948 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Poor general health was associated with acute graft-versus-host disease (GVHD), low self-efficacy, and cord blood stem cells. | 25322970 |
| Cessation of life, Coronary Arteriosclerosis | Stem Cell Exhaustion | Reduced circulating progenitor cell counts, identified primarily as CD34(+) mononuclear cells or its subset expressing CD133, are associated with risk of death in individuals with coronary artery disease, suggesting that impaired endogenous regenerative capacity is associated with increased mortality. | 25323857 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | Circulating CD34+ progenitor cells and risk of mortality in a population with coronary artery disease. | 25323857 |
| Neoplasms | Stem Cell Exhaustion | A phase I dose escalation and expansion study of the anticancer stem cell agent demcizumab (anti-DLL4) in patients with previously treated solid tumors. | 25324140 |
| Systemic Scleroderma | Stem Cell Exhaustion | Autologous stem cell transplantation in a patient with severe systemic sclerosis. | 25326407 |
| Specialty Type - cancer | Stem Cell Exhaustion | The Cancer Genome Atlas (TCGA) provides a unique resource for comprehensive discovery of mutations and genes in blood that may contribute to the clonal expansion of hematopoietic stem/progenitor cells. | 25326804 |
| Anthracycline Antibiotics | Stem Cell Exhaustion | First-line anthracycline-based chemotherapy significantly improved time-to-next-treatment even in patients receiving salvage autologs stem cell transplantation (P = 0.041). | 25327841 |
| Hypertension, CTCAE, Ventricular hypertrophy | Stem Cell Exhaustion | Increased mobilization of mesenchymal stem cells in patients with essential hypertension: the effect of left ventricular hypertrophy. | 25329239 |
| Cardiovascular Diseases | Stem Cell Exhaustion | Stem cells have great clinical significance in many cardiovascular diseases. | 25329239 |
| Hypertension, CTCAE | Stem Cell Exhaustion | However, there are limited data regarding the involvement of mesenchymal stem cells (MSCs) in the pathophysiology of arterial hypertension. | 25329239 |
| Atherosclerosis, Retinal Neovascularization, Reperfusion Injury | Stem Cell Exhaustion | Longevinex(r) (L/RV) is a low dose hormetic over-the-counter (OTC) oral resveratrol (RV) based matrix of red wine solids, vitamin D3 and inositol hexaphosphate (IP6) with established bioavailability, safety, and short-term efficacy against the earliest signs of human atherosclerosis, murine cardiac reperfusion injury, clinical retinal neovascularization, and stem cell survival. | 25329968 |
| Lymphoma, Multiple Myeloma, Acute leukemia | Stem Cell Exhaustion | A single-center, prospective, non-randomized clinical study was performed to examine the safety and feasibility of early discharge in patients undergoing consolidation chemotherapy for acute leukemia, or autologous stem cell transplant for lymphoma or multiple myeloma. | 25330445 |
| Neoplasms, Cytogenetic Complete Response | Stem Cell Exhaustion | In order to identify other CRC stem cell-specific genes, we performed a comparative expression profiling of CD133(+) and CD133(-) cell populations in primary and metastatic tumors from four patients with CRC. | 25331798 |
| Colorectal Carcinoma | Stem Cell Exhaustion | Transcriptome analysis of CD133-positive stem cells and prognostic value of survivin in colorectal cancer. | 25331798 |
| Colorectal Carcinoma, Cytogenetic Complete Response | Stem Cell Exhaustion | CD133 is an important, but not exclusive, biomarker of colorectal cancer (CRC) stem cells. | 25331798 |
| Cytogenetic Complete Response | Stem Cell Exhaustion | Our data suggest that CD133(+) CRC stem cells have a distinct expression pattern and that survivin, up-regulated by differentially expressed IL-4, is a candidate biomarker for the prediction of recurrence and survival in CRC. | 25331798 |
| Corneal Endothelial Cell Loss | Stem Cell Exhaustion | Emerging cellular markers of endothelial damage and repair include endothelial microparticles (EMPs) and endothelial progenitor cells (EPCs), respectively. | 25332321 |
| Hollings Cancer Center | Stem Cell Exhaustion | The therapeutic value of GPx3 for HCC was further investigated using human induced pluripotent stem cell derived mesenchymal stem cells (hiPSC-MSCs) as its delivery vehicle. | 25333265 |
| Cerebrovascular accident | Stem Cell Exhaustion | Stem cell therapy is an emerging therapeutic modality in the treatment of stroke. | 25333752 |
| Fever | Stem Cell Exhaustion | The most common side effect of stem cell transplantation in these six cases was low fever that usually lasted 2-4 days after each therapy. | 25333752 |
| Ischemic stroke | Stem Cell Exhaustion | A two-year follow-up study of cotransplantation with neural stem/progenitor cells and mesenchymal stromal cells in ischemic stroke patients. | 25333752 |
| Ischemic stroke | Stem Cell Exhaustion | We assessed the safety and feasibility of the cotransplantation of neural stem/progenitor cells (NSPCs) and mesenchymal stromal cells (MSCs) in patients with ischemic stroke. | 25333752 |
| Chronic Obstructive Airway Disease, Coughing | Stem Cell Exhaustion | [Patient with COPD after allogeneic hematopoietic stem cell transplantation with cough and subfebrile temperature]. | 25334076 |
| Chronic Obstructive Airway Disease, Coughing | Stem Cell Exhaustion | A 53-year-old male presents with progressive cough and subfebrile temperatures with a history of COPD and post one-year allogeneic hematopoietic stem cell transplantation. | 25334076 |
| Malignant neoplasm of lung, Specialty Type - cancer | Stem Cell Exhaustion | Clinical significance of putative cancer stem cell marker CD44 in different histological subtypes of lung cancer. | 25335738 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | According to the cancer stem cell theory, tumors originate from a subset of cells known as cancer stem cells (CSCs) that are responsible for tumor initiation, resistance and relapse. | 25335738 |
| Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Adult patients with acute myeloid leukemia and myelodysplastic syndrome on induction therapy or allogeneic hematopoietic stem cell transplant recipients were randomized (1:1 ratio) to 1 of 2 arms: "GM-PCR group" (the results of serial serum GM and PCR assays were provided to treating physicians) and "GM group" (only the results of serum GM were informed). | 25336623 |
| Avascular Necrosis of Femur Head | Stem Cell Exhaustion | [Treatment of non-traumatic femoral head avascular necrosis by perfusion of bone marrow stromal stem cells through optional artery]. | 25338442 |
| Avascular Necrosis of Femur Head | Stem Cell Exhaustion | To study the medium and long term effects of perfusion of bone marrow stromal stem cells through optional artery for the treatment of non-traumatic femoral head avascular necrosis. | 25338442 |
| Avascular Necrosis of Femur Head | Stem Cell Exhaustion | From January 2000 to December 2004,62 cases(78 hips) with non-traumatic femoral head necrosis accepted optional artery marrow stromal stem cells infusion treatment and had complete follow-up data, including 43 hips of 35 males and 35 hips of 27 females with an average age of 36.3 years old (22 to 54). | 25338442 |
| Avascular Necrosis of Femur Head, Thickened | Stem Cell Exhaustion | Perfusion of bone marrow stromal stem cells through optional artery can effective treat non-traumatic femoral head necrosis of ARCO I, II period, it can make the femoral circumflex artery and its branches increased thickening. | 25338442 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | This study was aimed to explore the effect and feasibility of reduced conditioning intensity allogeneic hematopoietic stem cell transplantation (allo-HSCT) in the treatment of relapsed ETO positive acute myeloid leukemia (AML) patients. | 25338589 |
| Graft-vs-Host Disease, Toxic effect | Stem Cell Exhaustion | The preventive donor's peripheral blood stem cell infusion were performed after 3 months of transplantation, and the toxicity, GVHD and disease-free survival were observed in patients after transplantation. | 25338589 |
| Specialty Type - cancer, Skin Neoplasms | Stem Cell Exhaustion | Co-expression of putative cancer stem cell markers, CD133 and Nestin, in skin tumors. | 25339000 |
| Specialty Type - cancer, Neoplasms, Malignant Neoplasms | Stem Cell Exhaustion | Cancer stem cells (CSC) are populations of cells responsible for tumor initiation, progression and therapeutic resistance in many cancers. | 25339000 |
| Malignant Neoplasms | Stem Cell Exhaustion | CD133 is one of the most important stem cell markers in solid cancers and Ki-67 is a marker that reflects cell proliferation. | 25339008 |
| Chronic Kidney Diseases | Stem Cell Exhaustion | In the present study, we investigated the potential involvement of endothelial microparticles (MPs) and endothelial progenitor cells (EPCs) in the generation of VC in CKD patients. | 25339701 |
| Liver Cirrhosis, Hypertension, CTCAE | Stem Cell Exhaustion | [Clinical efficacy of autologous mesenclyme multipotential stem cells transplantation in the liver cirrhosis and portal hypertension treatment]. | 25341236 |
| Liver Cirrhosis, Hypertension, CTCAE | Stem Cell Exhaustion | In 14 patients with cirrhosis and portal hypertention autologous mesenclyme multipotential stem cells (AMMSC) transplanation was performed in portal vein (I group, n=7) and common trunk of the hepatic artery (II group, n=6). | 25341236 |
| Stable chronic Graft vs Host Disease, Dry Eye Syndromes | Stem Cell Exhaustion | These results emphasize the role of aqueous-deficient and evaporative dry eye disease in patients with cGVHD after undergoing allogeneic hematologic stem cell transplantation. | 25343699 |
| Toxic effect | Stem Cell Exhaustion | SINV is used as a vector for the delivery of genes into selected neural stem cell lines; however, the toxicity and side effects of this vector have rarely been discussed. | 25343994 |
| Cessation of life, Communicable Diseases | Stem Cell Exhaustion | In this context, we investigated the cellular responses of human embryonic stem cell (hESCs) derived neural progenitors (hNPCs) to SINV infection by assessing susceptibility of the cells to SINV infection, analyzing the effect of infection on cell proliferation and cell death, and examining the impact of SINV infection on hNPCs markers of stemness. | 25343994 |
| Toxic effect | Stem Cell Exhaustion | On the other hand, the toxicity of SINV to hNPCs cells cannot be ignored, and therefore extra care should be taken when using SINV as a vector to deliver genes into human stem cell lines. | 25343994 |
| Radiation injury of bone marrow | Stem Cell Exhaustion | Maitake mushroom beta-glucan, a dietary supplement, stimulates hematopoietic progenitor cell differentiation, granulocyte colony-stimulating factor production, and recovery of peripheral blood leukocytes after bone marrow injury. | 25351719 |
| Hair follicle structure | Stem Cell Exhaustion | Spiradenoma and cylindroma originate from the hair follicle bulge and not from the eccrine sweat gland: an immunohistochemical study with CD200 and other stem cell markers. | 25354097 |
| Neoplasms | Stem Cell Exhaustion | Follicular stem cell markers may allow for further characterization of these neoplasms. | 25354097 |
| Neoplasms | Stem Cell Exhaustion | A total of 97 tumors were examined for the expression pattern of follicular stem cell markers cytokeratin 15 (CK15), cytokeratin 19 (CK19), pleckstrin homology-like domain, family A, member 1 (PHLDA1), and CD200. | 25354097 |
| Lymphoma | Stem Cell Exhaustion | Intermediate doses of cytarabine plus granulocyte-colony-stimulating factor as an effective and safe regimen for hematopoietic stem cell collection in lymphoma patients with prior mobilization failure. | 25354577 |
| Lymphoma | Stem Cell Exhaustion | High-dose chemotherapy supported by autologous stem cell transplantation (ASCT) is an effective treatment for patients with lymphomas. | 25354577 |
| Failure | Stem Cell Exhaustion | However, failure to reach the minimum threshold of hematopoietic stem cells to proceed to ASCT may occur, even with the most effective strategies currently available. | 25354577 |
| Specialty Type - cancer, Glioblastoma | Stem Cell Exhaustion | As Cancer stem cell (CSC) plays a pivotal role in the resistance to conventional cancer therapy, we explored the effects of MSC500 on the CSC-like side population (SP) in GBM8401 human glioblastoma multiforme cells. | 25359730 |
| Specialty Type - cancer, Glioblastoma | Stem Cell Exhaustion | Metformin exposure induces antiproliferative effects in cancer stem cell-enriched cultures, isolated from three individual WHO grade IV human glioblastomas. | 25361004 |
| Failure, Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | The lack of drugs affecting cancer stem cell viability is the main cause of therapy failure and tumor relapse. | 25361004 |
| Adult Glioblastoma | Stem Cell Exhaustion | Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current. | 25361004 |
| Adult Glioblastoma | Stem Cell Exhaustion | Metformin inhibition of CLIC1 activity induces G1 arrest of glioblastoma stem cells. | 25361004 |
| Adult Glioblastoma | Stem Cell Exhaustion | We identified CLIC1 not only as a modulator of cell cycle progression in human glioblastoma stem cells but also as the main target of metformin's antiproliferative activity, paving the way for novel and needed pharmacological approaches to glioblastoma treatment. | 25361004 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Down-regulation of Dicer1 promotes cellular senescence and decreases the differentiation and stem cell-supporting capacities of mesenchymal stromal cells in patients with myelodysplastic syndrome. | 25361944 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Collectively, the results of our study show that mesenchymal stromal cells from patients with myelodysplastic syndrome are prone to senescence and that Dicer1 down-regulation promotes cellular senescence and decreases the differentiation and stem cell-supporting capacities of mesenchymal stromal cells. | 25361944 |
| Neoplasms | Stem Cell Exhaustion | Bromodomain PHD-finger transcription factor (BPTF) could regulate embrogenesis and stem cell differentiation, and it may be involved in tumor progression and EMT. | 25362514 |
| Cerebral Hemorrhage | Stem Cell Exhaustion | In this study, we aimed to explore the curative effect and safety of neural stem cell intrathecal transplantation for the treatment of cerebral hemorrhage. | 25366723 |
| Cerebral Hemorrhage | Stem Cell Exhaustion | Curative effect and safety of intrathecal transplantation of neural stem cells for the treatment of cerebral hemorrhage. | 25366723 |
| Cerebral Hemorrhage | Stem Cell Exhaustion | We transplanted 4.0 x 10(8) neural stem cells per procedure into the subarachnoid space by lumbar puncture 7 days after cerebral hemorrhage, twice a week, a total of 4 times. | 25366723 |
| Cerebral Hemorrhage | Stem Cell Exhaustion | Our data suggest that the use of neural stem cells in intrathecal transplantation for the treatment of cerebral hemorrhage is safe and effective. | 25366723 |
| Febrile Neutropenia | Stem Cell Exhaustion | Neutropenic fever following hematologic stem cell transplantation was found in three cases. | 25367410 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Angiopoietins in haematopoietic stem cell mobilisation in patients with haematological malignancies. | 25369606 |
| Multiple Myeloma | Stem Cell Exhaustion | Evaluation of risk of symptomatic cytomegalovirus reactivation in myeloma patients treated with tandem autologous stem cell transplantation and novel agents: a single-institution study. | 25369809 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Our data are consistent with the recent finding of preleukaemic stem cells in AML, which are resistant to chemotherapy. | 25371149 |
| leukemia | Stem Cell Exhaustion | Incidence, risk factors and clinical outcome of leukemia relapses with loss of the mismatched HLA after partially incompatible hematopoietic stem cell transplantation. | 25371177 |
| leukemia | Stem Cell Exhaustion | Genomic loss of the mismatched human leukocyte antigen (HLA) is a recently described mechanism of leukemia immune escape and relapse after allogeneic hematopoietic stem cell transplantation (HSCT). | 25371177 |
| Malignant tumor of colon | Stem Cell Exhaustion | Ascl2, a basic helix-loop-helix transcription factor, is a downstream target of WNT signaling that controls the fate of intestinal cryptic stem cells and colon cancer progenitor cells. | 25371200 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Nocardia asteroides subretinal abscess in patient with acute myelogenous leukemia after allogeneic stem cell transplant. | 25372323 |
| Deteriorating vision, Abscess | Stem Cell Exhaustion | A 40-year-old man with a history of allogeneic stem cell transplant presents with decreased vision and a macular subretinal abscess. | 25372323 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplantation for relapsed follicular lymphoma: safety profile and clinical outcome in a single-center experience. | 25373321 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplantation (AHSCT) is a treatment option for relapsed and recurrent follicular lymphoma (R/R FL); however, its value in the rituximab era remains to be elucidated. | 25373321 |
| PAFAH1B1 wt Allele, leukemia, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | A retrospective single-center analysis was performed on patients with leukemia or myelodysplastic syndrome (MDS), aged <=20 years, who had received an 8-Gy TBI/FLU/CY RTMAC regimen followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 25373730 |
| Malignant neoplasm of urinary bladder | Stem Cell Exhaustion | A recent genome wide association study (GWAS) identified an association between the rs2294008 polymorphism of the prostate stem cell antigen (PSCA) gene and bladder cancer risk in Caucasians. | 25374226 |
| Immunocompromised Host | Stem Cell Exhaustion | Human adenoviruses (HAdV) are important viral pathogens recognized increasingly in immunocompromised hosts, especially in allogeneic haematopoietic stem cell transplant recipients (alloHSCT). | 25376263 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Allogeneic stem cell transplantation (SCT) provides the best mechanism of preventing relapse in acute myeloid leukaemia (AML). | 25376374 |
| Ischemic stroke | Stem Cell Exhaustion | Intravenous autologous bone marrow mononuclear stem cell therapy for ischemic stroke: a multicentric, randomized trial. | 25378424 |
| Cerebrovascular accident | Stem Cell Exhaustion | Pilot studies have suggested benefit from intravenous administration of bone marrow mononuclear stem cells (BMSCs) in stroke. | 25378424 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | Comparative proteomics analysis of gastric cancer stem cells. | 25379943 |
| Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | Cancer stem cells (CSCs) are responsible for cancer progression, metastasis, and recurrence. | 25379943 |
| Specialty Type - cancer | Stem Cell Exhaustion | The stem cell factor (SCF) receptor CD117 (c-kit), is widely used for identification of hematopoietic stem cells and cancer stem cells. | 25380303 |
| FAP protein, human, Neoplasms | Stem Cell Exhaustion | The CD117 positive fibroblast-like stromal cells were all positive for mesenchymal stem/stromal cell (MSC) marker CD73 but negative for fibroblast markers fibroblast activation protein (FAP) and a smooth muscle actin (a-SMA), indicating that the CD117+/CD73+ fibroblast-like stromal cells are a subtype of mesenchymal stem cells in tumor stroma, although further characterization of these cells are needed. | 25380303 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Contribution of non-infectious transplantation-related complications to the outcome of hematopoietic stem cell transplantation in patients with acute myeloid leukemia: a single institute analysis. | 25380682 |
| Primary amyloidosis | Stem Cell Exhaustion | High-dose melphalan and autologous hematopoietic stem cell transplantation in primary amyloidosis: single-center results. | 25380940 |
| Malignant neoplasm of stomach, Specialty Type - cancer | Stem Cell Exhaustion | Overexpression of NRG1 promotes progression of gastric cancer by regulating the self-renewal of cancer stem cells. | 25381017 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | Gastric cancer stem cells (GCSCs) have been successfully isolated from patients. | 25381017 |
| Adult Glioblastoma | Stem Cell Exhaustion | Identification of OLIG2 as the most specific glioblastoma stem cell marker starting from comparative analysis of data from similar DNA chip microarray platforms. | 25384509 |
| Glioblastoma Multiforme Pathway, Specialty Type - cancer | Stem Cell Exhaustion | The cancer stem cell concept suggests that a rare stem cell population, called glioma stem cells (GSCs), has high ability to self-renewal leading to recurrence in GBM. | 25384509 |
| Thrombotic Microangiopathies | Stem Cell Exhaustion | Fragmented Red Cell as a Possible Favorable Prognostic Marker of Hematopoietic Stem Cell Transplantation Associated Thrombotic Microangiopathy. | 25385174 |
| Thrombotic Microangiopathies | Stem Cell Exhaustion | In this study, it is noted that FRC might be a favorable prognostic marker of hematopoietic stem cell transplantation associated thrombotic microangiopathy (TA-TMA). | 25385174 |
| Chronic heart failure, ventricular mass | Stem Cell Exhaustion | Left ventricular mass and progenitor cells in chronic heart failure patients. | 25387824 |
| Chronic heart failure | Stem Cell Exhaustion | The aim of the study was to evaluate the association between circulating (CPCs) and endothelial (EPCs) progenitor cells and left ventricular (LV) remodeling in chronic heart failure (HF). | 25387824 |
| B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Phase 1/2 study of nilotinib prophylaxis after allogeneic stem cell transplantation in patients with advanced chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia. | 25387866 |
| Myeloid Leukemia, Chronic, B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1, BCR gene | Stem Cell Exhaustion | Allogeneic stem cell transplantation (SCT) remains the standard treatment for advanced chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL). | 25387866 |
| TFE3 Positive | Stem Cell Exhaustion | Loss of microphthalmia-associated transcription factor-positive root sheath cells was seen, suggestive of loss of melanocyte stem cells. | 25388912 |
| Encephalitis, Acute lymphocytic leukemia | Stem Cell Exhaustion | Proven Epstein-Barr encephalitis with negative EBV-DNA load in cerebrospinal fluid after allogeneic hematopoietic stem cell transplantation in a child with acute lymphoblastic leukemia. | 25388950 |
| Atherosclerosis | Stem Cell Exhaustion | Mesenchymal stem cells alleviate atherosclerosis by elevating number and function of CD4(+)CD25 (+)FOXP3 (+) regulatory T-cells and inhibiting macrophage foam cell formation. | 25389006 |
| Plaque, Atherosclerotic | Stem Cell Exhaustion | Here, we studied the effect of bone marrow-derived mesenchymal stem cells (BM-MSCs) on atherosclerotic plaque formation in Apolipoprotein E(-/-) (ApoE-KO) mice, and elucidated the underlying mechanism. | 25389006 |
| Parkinson Disease | Stem Cell Exhaustion | Here, we investigated if induced pluripotent stem cell-derived neuronal precursor cells (NPCs) from a patient with Parkinson's disease carrying a genomic triplication of the SNCA gene (SNCA-Tri). | 25390032 |
| palladium | Stem Cell Exhaustion | The observation of this "stem cell pathology" could have a great impact on both quality and quantity of neuronal networks and could provide a powerful new tool for development of neuroprotective strategies for PD. | 25390032 |
| palladium | Stem Cell Exhaustion | The impact of altered a-synuclein protein expression on integrity and developmental potential of neuronal stem cells is largely unexplored, but may have wide ranging implications for PD manifestation and disease progression. | 25390032 |
| ELN wt Allele | Stem Cell Exhaustion | Recent studies have revealed that cells from WS patients can be successfully reprogrammed into induced pluripotent stem cells (iPSCs). | 25390333 |
| Osteosarcoma, Specialty Type - cancer | Stem Cell Exhaustion | Bone morphogenetic protein-2 (BMP-2) plays important roles in the development of bone and cartilage and in inhibiting the tumorigenicity of cancer stem cells in human osteosarcoma cell line. | 25391427 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | Upfront allogeneic stem-cell transplantation for patients with nonlocalized untreated peripheral T-cell lymphoma: an intention-to-treat analysis from a single center. | 25392158 |
| Bulbo-Spinal Atrophy, X-Linked | Stem Cell Exhaustion | Human adipose-derived mesenchymal stem cells as a new model of spinal and bulbar muscular atrophy. | 25392924 |
| Bulbo-Spinal Atrophy, X-Linked, Toxic effect | Stem Cell Exhaustion | Here, we propose the use of SBMA patients adipose-derived mesenchymal stem cells (MSCs) as a new human in vitro model to study ARpolyQ toxicity. | 25392924 |
| Malignant Peripheral Nerve Sheath Tumor | Stem Cell Exhaustion | The patogenetic importance of Nrf2 depletion in the context of expansion of the hematopoietic progenitor pool in MPNs is discussed with particular focus upon the implications of concomitant downregulation of Nrf2 and CXCR4 for stem cell mobilization. | 25397683 |
| Communicable Diseases | Stem Cell Exhaustion | Single-nucleotide polymorphisms (SNPs) in immune genes have been associated with susceptibility to invasive mold infection (IMI) among hematopoietic stem cell but not solid-organ transplant (SOT) recipients. | 25398456 |
| Rhabdomyosarcoma | Stem Cell Exhaustion | Successful treatment of metastatic rhabdomyosarcoma with radiochemotherapy and allogeneic hematopoietic stem cell transplantation. | 25398582 |
| Rhabdomyosarcoma | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation for rhabdomyosarcoma should be done by experienced clinical oncologists on properly designed controlled trials. | 25398582 |
| Immunocompromised Host, Communicable Diseases | Stem Cell Exhaustion | Due to the increasing number of immunocompromised patients and widely used autologous stem cell transplantation procedures, clinicians have to face with the emergence of infectious diseases. | 25398808 |
| Communicable Diseases | Stem Cell Exhaustion | Herein, we present monitoring of HHV-6 virus re-activation and infection in patients after autologous stem cell transplantation. | 25398808 |
| Dermatologic disorders, Polyneuropathy | Stem Cell Exhaustion | After autologous stem cell transplantation, patients proceeded to KTd consolidation therapy, where the target doses of carfilzomib were 27 mg/m(2), 36 mg/m(2), 45 mg/m(2), or 56 mg/m(2), respectively, and thalidomide 50 mg. Common grade 3/4 adverse events included respiratory (15%), gastrointestinal (12%), and skin disorders (10%); polyneuropathy was infrequent (1%). | 25398935 |
| Neoplasms | Stem Cell Exhaustion | In addition to patient demographics, tumor pathology, treatment regimens, and clinical outcomes, we compared putative cancer stem cell marker CD133 expression patterns in primary and metastatic lesions as well as in recurrent EOC with and without CNS metastases. | 25399490 |
| Multiple Myeloma | Stem Cell Exhaustion | In vitro migratory aberrancies of mesenchymal stem cells derived from multiple myeloma patients only partially modulated by bortezomib. | 25400750 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Recent studies indicated that bone marrow mesenchymal stem cells (BM-MSCs) derived from multiple myeloma (MM) patients were different from those of normal subjects in a variety of aspects. | 25400750 |
| Liver carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Downregulation of PRRX1 Confers Cancer Stem Cell-Like Properties and Predicts Poor Prognosis in Hepatocellular Carcinoma. | 25404478 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Downregulation of paired related homeobox 1 (PRRX1) is associated with the acquisition of cancer stem cell (CSC)-like properties and poor prognosis in cancers. | 25404478 |
| Spinal Cord Injuries | Stem Cell Exhaustion | Safety and neurological assessments after autologous transplantation of bone marrow mesenchymal stem cells in subjects with chronic spinal cord injury. | 25406723 |
| Stanford Cancer Institute, Spinal Cord Injuries | Stem Cell Exhaustion | The administration of stem cells holds promise as a potential therapy for spinal cord injury (SCI). | 25406723 |
| Stanford Cancer Institute | Stem Cell Exhaustion | Here we evaluated the feasibility, safety and potential efficacy of autologous transplantation of mesenchymal stem cells in subjects with chronic complete SCI. | 25406723 |
| Spinal Cord Injuries | Stem Cell Exhaustion | Intralesional transplantation of autologous mesenchymal stem cells in subjects with chronic, complete spinal cord injury is safe, feasible, and may promote neurological improvements. | 25406723 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | A computational model incorporating neural stem cell dynamics reproduces glioma incidence across the lifespan in the human population. | 25409511 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Since evidence implicates the adult neural stem cell as the likely cell-of-origin of glioma, we have incorporated empirically-determined estimates of neural stem cell number, cell division rate, mutation rate and oncogenic potential into our model. | 25409511 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Overall, our model supports the hypothesis that glioma is caused by randomly-occurring oncogenic mutations within the neural stem cell population. | 25409511 |
| Acute leukemia, Myelodysplastic-Myeloproliferative Diseases | Stem Cell Exhaustion | Initial fluconazole prophylaxis may not be required in adults with acute leukemia or myelodysplastic/myeloproliferative disorders after reduced intensity conditioning peripheral blood stem cell allogeneic transplantation. | 25409914 |
| Mycoses | Stem Cell Exhaustion | Recent changes in transplantation practices, including the use of peripheral blood stem cells (PBSC) and/or reduced intensity conditioning (RIC) regimen may have favorably impacted the epidemiology of invasive fungal infections (IFI) after allogeneic stem cell transplantation (allo-SCT). | 25409914 |
| Diabetes | Stem Cell Exhaustion | By observing the curative effect of autologous stem cells changes before and after the treatment, to explore the stem cell treatment of diabetes and its complications. | 25410077 |
| Complications of Diabetes Mellitus | Stem Cell Exhaustion | This research and application of autologous bone marrow stem cell transplantation for treatment of type 2 diabetes chronic complications achieves certain results, non-toxic side effects occuring. | 25410077 |
| Diabetes | Stem Cell Exhaustion | Clinical observation of 32 cases with transplantation of autologous bone marrow stem cells on diabetes and its complications. | 25410077 |
| Lymphoma | Stem Cell Exhaustion | Outcome determinants for transformed indolent lymphomas treated with or without autologous stem-cell transplantation. | 25411416 |
| nervous system disorder | Stem Cell Exhaustion | Umbilical cord-derived mesenchymal stem cell therapy for neurological disorders via inhibition of mitogen-activated protein kinase pathway-mediated apoptosis. | 25412281 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer patients, specifically those undergoing invasive surgery, constitute a subgroup of patients who could benefit from autologous stem cell transplantation. | 25412325 |
| Specialty Type - cancer | Stem Cell Exhaustion | In addition, vesicles <100 nm identified as exosomes (EXOs) which may be at least partly responsible for the attributed therapeutic paracrine effects of the ADSCs were effectively isolated from ADSCs and showed equivalent miRNA content regardless they were derived from cancer patients or non-oncogenic participants indicating that the repair capabilities of xeno-free expanded ADSCs are not compromised by patient condition and therefore their xeno-free culture expanded ADSCs should be suitable for autologous stem cell transplantation in a clinical setting. | 25412325 |
| Specialty Type - cancer | Stem Cell Exhaustion | Therapeutic potential of human adipose-derived stem cells (ADSCs) from cancer patients: a pilot study. | 25412325 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Equivalent outcome of autologous stem cell transplantation and reduced intensity conditioning stem cell transplantation in acute myeloid leukemia patients with t(8;21). | 25413265 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We analyzed the outcome of stem cell transplantation (SCT) for 59 acute myeloid leukemia (AML) patients with t(8;21). | 25413265 |
| Neutropenia, Communicable Diseases | Stem Cell Exhaustion | Multivariable regression analysis indicated prolonged hospitalization, presence of central venous catheterization, neutropenia, current stem cell transplant, infection on admission, and old age were independently associated with higher NI incidence. | 25415334 |
| Myocardial Ischemia | Stem Cell Exhaustion | Meta-analysis of coronary artery bypass graft surgery combined with stem cell transplantation in the treatment of ischemic heart diseases. | 25415856 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Magnetic resonance enterography for assessment of intestinal graft-versus-host disease after allogeneic stem cell transplantation. | 25417129 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | To determine the diagnostic performance of MR enterography (MRE) for detection and grading of gastrointestinal graft-versus-host disease (GI GvHD) after hematopoietic stem cell transplantation (SCT). | 25417129 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | After allogeneic stem cell transplantation, MRE may (1) contribute to detection and localization of GI GvHD, and (2) add information indicating the clinical severity of disease, but findings are unspecific. | 25417129 |
| Ischemic cardiomyopathy | Stem Cell Exhaustion | The graft of stem cells to treat ischemic cardiomyopathy is popular in many clinical trials. | 25418212 |
| Injury of large intestine | Stem Cell Exhaustion | Complete knockout of Id1 or selective deletion of Id1 in intestinal epithelium or in LGR5+ stem cells sensitizes mice to chemical-induced colon injury. | 25418719 |
| Injury of large intestine | Stem Cell Exhaustion | These experiments identify ID1 as a marker for intestinal stem/progenitor cells and demonstrate a role for ID1 in maintaining the potential for repair in response to colonic injury. | 25418719 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Here, we show that cartilage tissue harvested from the avascular inner human meniscus during the late stages of osteoarthritis harbors a unique progenitor cell population. | 25418724 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | IL-6 secreted from senescent mesenchymal stem cells promotes proliferation and migration of breast cancer cells. | 25419563 |
| Childhood Breast Carcinoma, Neoplasms | Stem Cell Exhaustion | In the current study, by establishing senescent human umbilical cord mesenchymal stem cells (s-UCMSCs) through the replicative senescence model and genotoxic stress induced premature senescence model, we show that s-UCMSCs significantly stimulate proliferation and migration of breast cancer cells in vitro and tumor progression in a co-transplant xenograft mouse model compared with 'young' counterparts (defined as MSCs at passage 5, in contrast to senescent MSCs at passage 45). | 25419563 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | This study investigated the role of cytokines and chemokines in aGVHD incidence and severity in 109 patients who underwent reduced-intensity conditioning allogeneic stem cell transplantation (HSCT). | 25420917 |
| Hepatitis B | Stem Cell Exhaustion | Reactivation of hepatitis B virus in hematopoietic stem cell transplant recipients in Japan: efficacy of nucleos(t)ide analogues for prevention and treatment. | 25421241 |
| Hematologic Neoplasms | Stem Cell Exhaustion | We retrospectively reviewed 413 recipients with hematologic malignancies who underwent hematopoietic stem cell transplantation (HSCT) between June 1986 and March 2013. | 25421241 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The current survey compared transplantation outcomes for a cohort of 394 acute myeloid leukemia (AML) patients given bone marrow or peripheral blood stem cells from human leukocyte antigen-identical siblings after FB (n = 218) or FM (n = 176). | 25424330 |
| Liver carcinoma | Stem Cell Exhaustion | Hypoxia after transarterial chemoembolization may trigger a progenitor cell phenotype in hepatocellular carcinoma. | 25425262 |
| Aggressive course | Stem Cell Exhaustion | Hypoxia may trigger the expression of proteins that are normally associated with cholangiocytic/progenitor cell differentiation, suggesting that TACE paradoxically causes an aggressive tumour phenotype. | 25425262 |
| Liver Cirrhosis, Hepatitis B | Stem Cell Exhaustion | Entecavir promotes CD34+ stem cell proliferation in the peripheral blood and liver of chronic hepatitis B and liver cirrhosis patients. | 25425463 |
| trauma qualifier | Stem Cell Exhaustion | ETV-activated stem cells in bone marrow and liver tissues may contribute to the recovery from injuries caused by HBV infection. | 25425463 |
| Hollings Cancer Center | Stem Cell Exhaustion | Meanwhile, ETV does not activate stem cells that may participate in the initiation of HCC. | 25425463 |
| Acinar Cell Carcinoma | Stem Cell Exhaustion | Our studies indicate that activation of mTOR signaling in the pancreatic progenitor cells may trigger the development of acinar carcinoma. | 25425965 |
| Specialty Type - cancer, Neoplasms, Glioblastoma | Stem Cell Exhaustion | The AC133 epitope of CD133 is a cancer stem cell (CSC) marker for many tumor entities, including the highly malignant glioblastoma multiforme (GBM). | 25426558 |
| Adult Glioblastoma | Stem Cell Exhaustion | Patient-derived glioblastoma stem cells are killed by CD133-specific CAR T cells but induce the T cell aging marker CD57. | 25426558 |
| Neoplasms | Stem Cell Exhaustion | We have developed an AC133-specific chimeric antigen receptor (CAR) and show that AC133-CAR T cells kill AC133+ GBM stem cells (GBM-SCs) both in vitro and in an orthotopic tumor model in vivo. | 25426558 |
| Chronic total occlusion of coronary artery | Stem Cell Exhaustion | Safety and efficacy of intracoronary human umbilical cord-derived mesenchymal stem cell treatment for very old patients with coronary chronic total occlusion. | 25427243 |
| Chronic total occlusion of coronary artery | Stem Cell Exhaustion | This study aimed to investigate the safety and feasibility of intracoronary injection of human umbilical cord mesenchymal stem cell to the very old patients with coronary chronic total occlusion. | 25427243 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We report results of a time-dependent multivariable analysis of allogenic hematopoietic stem cell transplantation (alloHSCT) (n=337) versus chemotherapy (n=271) or autologous HSCT (autoHSCT) (n=152) in 760 patients aged 40-60 years with AML in CR1. | 25428261 |
| Specialty Type - cancer, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Cancer stem cell is responsible for tumor initiation, metastasis and relapse. | 25428381 |
| Neoplasms, Invasive Ductal Breast Carcinoma | Stem Cell Exhaustion | Correlation between epidermal growth factor receptor and tumor stem cell markers CD44/CD24 and their relationship with prognosis in breast invasive ductal carcinoma. | 25429827 |
| Neoplasms, Invasive Ductal Breast Carcinoma | Stem Cell Exhaustion | We studied the correlation between epidermal growth factor receptor (EGFR) and the tumor stem cell markers CD44/CD24 in breast invasive ductal carcinoma (BIDC) and their relationship with prognosis. | 25429827 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Myelodysplastic syndromes (MDS) are clonal disorders of hematopoietic stem/progenitor cells. | 25430081 |
| Amyloidosis | Stem Cell Exhaustion | Only high-dose melphalan with auto-peripheral blood stem cell transplantation (PBSCT) has shown high long-term hematological response rates, but combinations with novel agents, including bortezomib or lenalidomide, have recently shown high hematological response rates for AL amyloidosis patients. | 25430082 |
| Acute leukemia, Infertility | Stem Cell Exhaustion | As the number of young long-term survivors of hematopoietic stem cell transplantation (HSCT) for acute leukemia continues to increase, post-transplant infertility is becoming a significant concern. | 25430084 |
| leukemia | Stem Cell Exhaustion | Total costs and clinical outcome of hematopoietic stem cell transplantation in adults with leukemia: comparison between reduced-intensity and myeloablative conditioning. | 25430486 |
| Primary Biliary Cholangitis | Stem Cell Exhaustion | CoH loss, reflecting a reduced supply of progenitor cells to the biliary tree, may be involved in the histological progression of PBC. | 25430494 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | The relationship between oral mucositis and levels of pro-inflammatory cytokines in serum and in gingival crevicular fluid in allogeneic stem cell recipients. | 25433441 |
| Gastrointestinal mucositis, Oman | Stem Cell Exhaustion | Oral mucositis (OM) is a severe side effect of conditioning for allogeneic hematopoietic stem cell transplantation (HSCT). | 25433441 |
| Acute leukemia | Stem Cell Exhaustion | A survey on unmanipulated haploidentical hematopoietic stem cell transplantation in adults with acute leukemia. | 25434302 |
| Acute leukemia | Stem Cell Exhaustion | The use of unmanipulated graft is increasingly adopted in the setting of allogeneic hematopoietic stem cell transplantation from haploidentical family donors (haplo-SCT) in acute leukemia (AL). | 25434302 |
| Anemia | Stem Cell Exhaustion | Oxymetholone therapy of fanconi anemia suppresses osteopontin transcription and induces hematopoietic stem cell cycling. | 25434823 |
| Bone marrow hypocellularity | Stem Cell Exhaustion | These results expand our knowledge of the regulation of hematopoietic stem cell proliferation and have direct clinical implications for the treatment of bone marrow failure. | 25434823 |
| Multiple Myeloma | Stem Cell Exhaustion | Autologous stem cell transplantation in multiple myeloma is not dead but alive and well. | 25435056 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | In multiple myeloma (MM), the use of high-dose chemotherapy with autologous stem cell transplantation (ASCT) led to incremental advances in patient management in the 1990s. | 25435056 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | CD133 is one of the cancer stem cell markers in solid cancers. | 25436343 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells (CSC) was reported to play an important role in various kinds of cancer. | 25436343 |
| Peripheral Blood Stem Cells | Stem Cell Exhaustion | All patients received peripheral blood stem cell infusion >1.5 x 10(6)/kg. | 25437249 |
| Neuroendocrine Tumors, Neoplasms | Stem Cell Exhaustion | Neuroendocrine tumors (NETs) of the ileum are sporadic tumors derived from submucosal gastrointestinal stem cells. | 25439321 |
| Malignant neoplasm of stomach, Specialty Type - cancer | Stem Cell Exhaustion | Combined epithelial-mesenchymal transition with cancer stem cell-like marker as predictors of recurrence after radical resection for gastric cancer. | 25441488 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | The aim of the study was to identify the incidence and the predictors of recurrence after curative resection and the clinical significance of epithelial-mesenchymal transition (EMT) and stem cell-like phenotypes in gastric cancer. | 25441488 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | The clinicopathological characteristics, including five EMT-related proteins (Snail-1, ZEB-1, E-cadherin, vimentin, and b-catenin) and the gastric cancer stem cell markers CD44 and CD54, therapeutic modalities, survival time after recurrence, and recurrence patterns were compared between the two groups. | 25441488 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | Loss of E-cadherin expression and aberrant expression of vimentin and the known gastric cancer stem cell maker CD44 were significantly associated with aggressive clinicopathologic features. | 25441488 |
| Neoplasms, Malignant neoplasm of stomach, Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | Multivariate analysis showed that stage III gastric cancer patients with early recurrence had larger tumors and more lymph node metastasis, coupled with aberrant expression EMT and cancer stem cell marker, than patients with late recurrence. | 25441488 |
| Malignant neoplasm of stomach, Specialty Type - cancer | Stem Cell Exhaustion | Combined EMT with cancer stem cell-like marker is a predictor of recurrence after radical resection for gastric cancer. | 25441488 |
| Ischemic stroke | Stem Cell Exhaustion | Circulating CD133+ CD34+ progenitor cells and plasma stromal-derived factor-1alpha: predictive role in ischemic stroke patients. | 25444027 |
| Chemical injury | Stem Cell Exhaustion | Circulating progenitor cells and stromal-derived factor-1alpha (SDF-1a) have been suggested to participate in tissue repair after ischemic injury. | 25444027 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Patients with multiple myeloma (MM) who are eligible for autologous stem cell transplantation (ASCT) typically receive a finite period of initial therapy before ASCT. | 25445028 |
| Multiple Myeloma | Stem Cell Exhaustion | Quantitative measures of physical functioning after autologous hematopoietic stem cell transplantation in multiple myeloma: a feasibility study. | 25445473 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | The safety and feasibility of the symptom-limited cardiopulmonary exercise test (CPET) and the 6-minute walk test (6MWT) has not been rigorously tested in patients with multiple myeloma (MM) after high-dose chemotherapy with autologous stem cell transplantation (ASCT), nor have correlations with patient-reported outcomes (PROs) been explored. | 25445473 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Nonmyeloablative allogeneic hematopoietic stem cell transplant for the treatment of patients with hematologic malignancies using busulfan, fludarabine, and total body irradiation conditioning is effective in an elderly and infirm population. | 25445641 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Patients with hematologic malignancies for whom limited long-term survival was expected with standard therapy were administered an outpatient conditioning regimen of busulfan 3.2 mg/kg IV on day -5, fludarabine 30 mg/m(2) IV on days -4, -3, -2, and 200 cGy of total body irradiation (TBI) followed by stem cell infusion from related or unrelated donors. | 25445641 |
| diabetic | Stem Cell Exhaustion | Normalization of wound healing and stem cell marker patterns in organ-cultured human diabetic corneas by gene therapy of limbal cells. | 25446319 |
| diabetic | Stem Cell Exhaustion | Overexpression of c-met and suppression of matrix metalloproteinase-10 (MMP-10) and cathepsin F genes was previously shown to normalize wound healing, epithelial and stem cell marker patterns in organ-cultured human diabetic corneas. | 25446319 |
| diabetic | Stem Cell Exhaustion | Corneal cryostat sections were immunostained for diabetic and putative limbal stem cell markers, a3b1 integrin, nidogen-1, fibronectin, laminin g3 chain, DNp63a, keratins 14, 15, and 17, as well as for activated signaling intermediates, phosphorylated EGFR, Akt, and p38. | 25446319 |
| Keratopathy, diabetic | Stem Cell Exhaustion | Gene therapy of limbal epithelial stem cell compartment has a beneficial effect on the diabetic corneal wound healing and on diabetic and stem cell marker expression, and shows potential for alleviating symptoms of diabetic keratopathy. | 25446319 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Current valid treatments for acute myeloid leukemia (AML) include chemotherapy and hematopoietic stem cell transplantation, which are defective and limited respectively. | 25448401 |
| MS gene, Spinal Cord Injuries, Parkinson Disease, Cerebrovascular accident | Stem Cell Exhaustion | The top five clinical indications for stem cell therapy were multiple sclerosis, anti-ageing, Parkinson's disease, stroke and spinal cord injury. | 25449045 |
| Pathogenesis of HIV Opportunistic Infection | Stem Cell Exhaustion | Human adenoviruses (HAdV) are known opportunistic pathogens in hematopoietic stem cell transplant (SCT) recipients. | 25449172 |
| Prostate carcinoma | Stem Cell Exhaustion | Loss of E-cadherin expression, a marker of EMT, and CD133, a putative prostate cancer stem cell marker, were characterized using the open channel of the CellSearch platform. | 25450039 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Achievement of early complete donor chimerism in CD25+-activated leukocytes is a strong predictor of the development of graft-versus-host-disease after stem cell transplantation. | 25450515 |
| Communicable Diseases | Stem Cell Exhaustion | Disseminated, persistent, and fatal infection due to the vaccine strain of varicella-zoster virus in an adult following stem cell transplantation. | 25452596 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | A middle-aged man with non-Hodgkin lymphoma received chemotherapy and a stem cell transplant. | 25452596 |
| Chronic myeloproliferative disorder, PRSS27 gene, Neoplasms, Precursor B-cell lymphoblastic leukemia | Stem Cell Exhaustion | B-lymphoblastic leukemia (B-ALL) is a neoplasm of precursors committed to B-cell lineage, whereas myeloproliferative neoplasm (MPN) is a clonal proliferation derived from myeloid stem cells. | 25453399 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial. | 25456364 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Interleukin 6 mediates graft-versus-host disease (GVHD) in experimental allogeneic stem-cell transplantation (allogeneic SCT) and represents an attractive therapeutic target. | 25456364 |
| Sezary Syndrome | Stem Cell Exhaustion | Long-Term Complete Responses to Combination Therapies and Allogeneic Stem Cell Transplants in Patients With Sezary Syndrome. | 25458083 |
| Mouth Diseases | Stem Cell Exhaustion | To report an oral disease management protocol before and after hematopoietic stem cell transplantation. | 25458262 |
| Ischemia, Acute lymphocytic leukemia | Stem Cell Exhaustion | Nonocclusive Mesenteric Ischemia after Chemotherapy in an Adolescent Patient with a History of Three Allogeneic Hematopoietic Stem Cell Transplantations for Acute Lymphoblastic Leukemia. | 25458640 |
| Age related macular degeneration, "Stargardts disease", Dystrophy | Stem Cell Exhaustion | Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies. | 25458728 |
| Neoplasms | Stem Cell Exhaustion | Since they were first derived more than three decades ago, embryonic stem cells have been proposed as a source of replacement cells in regenerative medicine, but their plasticity and unlimited capacity for self-renewal raises concerns about their safety, including tumour formation ability, potential immune rejection, and the risk of differentiating into unwanted cell types. | 25458728 |
| Cessation of life | Stem Cell Exhaustion | If targeted to a gene promoting cellular survival or decreasing cell death, it could potentially improve stem cell longevity in a more efficient and controllable manner. | 25459138 |
| Neoplasms, Malignant Neoplasms | Stem Cell Exhaustion | Each mutation is rare and the specific set is extremely rare so that even though there are millions of stem cells in a small area of mucosa the specific set of mutations to initiate the process of malignancy will only arise in one stem cell at most; hence neoplasia is clonal. | 25459141 |
| Inflammation, Trauma, Specialty Type - cancer, Ulceration, CTCAE | Stem Cell Exhaustion | This hierarchical model of stem cell genesis leads to a very low prevalence of cancer, unless the orderly progression of the hierarchy is disturbed by inflammation, ulceration or trauma. | 25459141 |
| Carcinogenesis | Stem Cell Exhaustion | The central dogma of carcinogenesis is that deleterious mutations accumulate in regularly cycling stem cells and eventually one of the cells will acquire a specific set of mutations which leads to uncontrolled cell proliferation. | 25459141 |
| Carcinogenesis | Stem Cell Exhaustion | It is suggested that the number of cell divisions that separate the zygote from stem cells is a key variable in carcinogenesis. | 25459141 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Feasible outcomes of T cell-replete haploidentical stem cell transplantation with reduced-intensity conditioning in patients with myelodysplastic syndrome. | 25459640 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Even with the recent optimization of haploidentical stem cell transplantation (SCT), its role for patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia evolving from MDS (sAML) should be validated. | 25459640 |
| Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Chronic graft-versus-host disease (cGVHD) is a serious and frequent complication of allogeneic hematopoietic stem cell transplantation (HCT). | 25460358 |
| Nephroblastoma, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Wilms tumor gene 1 expression as a predictive marker for relapse and survival after hematopoietic stem cell transplantation for myelodysplastic syndromes. | 25460359 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Nephroblastoma | Stem Cell Exhaustion | Relapse after allogeneic hematopoietic stem cell transplantation (HSCT) is a major concern in myelodysplastic syndromes (MDS), but the role of Wilms tumor gene 1 (WT1) as a predictive marker for post-HSCT relapse remains to be validated. | 25460359 |
| Hyperglycemia, Acute Coronary Syndrome | Stem Cell Exhaustion | Correction of hyperglycemia in patients with acute coronary syndrome rapidly reverses oxidative stress, restoring both platelet nitric oxide responsiveness and endothelial progenitor cell function, but this process is largely or entirely independent of thioredoxin-interacting protein. | 25460870 |
| Primary Myelofibrosis | Stem Cell Exhaustion | Myelofibrosis (MF) is characterized by the constitutive mobilization of hematopoietic stem cells (HSC) and hematopoietic progenitor cells (HPC) and the establishment of extramedullary hematopoiesis. | 25461253 |
| Stanford Cancer Institute | Stem Cell Exhaustion | At 0 to 3 DPI, levels of cytokines interleukin-6 (P<.00017), interleukin-9 (P<.0047), interleukin-16 (P<.007), interleukin-18 (P<.014), chemokines growth-related oncogene a/chemokine (C-X-C motif) ligand 1 (P<.0127) and macrophage inflammatory protein 1-b/chemokine (C-C motif) ligand 4 (P<.0015), and growth factors hepatocyte growth factor (HGF) (P<.0001) and stem cell growth factor-b (P<.0103) were also significantly elevated in subjects with acute SCI. | 25461821 |
| Systolic dysfunction | Stem Cell Exhaustion | Hematopoietic stem cell transplantation in patients with systolic dysfunction: can it be done? | 25464117 |
| leukemia, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | We analyzed adult patients with leukemia or myelodysplastic syndrome who received a first allogeneic stem cell transplant from an HLA-A, -B, -C, and -DRB1 matched or 1-allele mismatched unrelated donor in Japan. | 25464119 |
| Acute myocardial infarction | Stem Cell Exhaustion | Concurrent hypermulticolor monitoring of CD31, CD34, CD45 and CD146 endothelial progenitor cell markers for acute myocardial infarction. | 25467496 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | The circulating endothelial progenitor cells (EPCs) in blood of acute myocardial infarction (AMI) patient have been monitored in many previous studies. | 25467496 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Mithramycin A sensitizes therapy-resistant breast cancer stem cells toward genotoxic drug doxorubicin. | 25468484 |
| Specialty Type - cancer | Stem Cell Exhaustion | Accumulating evidence suggests a major role of cancer stem cells (CSCs) in chemoresistance evoking the requirement of drugs that selectively target CSCs in combination with chemotherapy. | 25468484 |
| Mandibular Fractures | Stem Cell Exhaustion | The osteogenic activity of human mandibular fracture haematoma-derived progenitor cells is affected by bisphosphonate in vitro. | 25468633 |
| atherosclerotic | Stem Cell Exhaustion | Lower levels of plasma adiponectin and endothelial progenitor cells are associated with large artery atherosclerotic stroke. | 25469454 |
| Toxic effect, Primary Myelofibrosis | Stem Cell Exhaustion | Treosulfan based reduced toxicity conditioning followed by allogeneic stem cell transplantation in patients with myelofibrosis. | 25469485 |
| Liver diseases | Stem Cell Exhaustion | Efforts to identify cell sources and approaches for cell therapy of liver diseases are ongoing, taking into consideration the limits recognized for adult liver tissue and for other forms of stem cells. | 25471120 |
| Liver Cirrhosis | Stem Cell Exhaustion | In the present study, we described the first procedure of via hepatic artery transplantation of human fetal biliary tree stem cells in patients with advanced cirrhosis. | 25471120 |
| Liver Cirrhosis | Stem Cell Exhaustion | This report represents proof of the concept that the human fetal biliary tree stem cells are a suitable and large source for cell therapy of liver cirrhosis. | 25471120 |
| Liver Cirrhosis | Stem Cell Exhaustion | Transplantation of human fetal biliary tree stem/progenitor cells into two patients with advanced liver cirrhosis. | 25471120 |
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Stem Cell Exhaustion | A 17-month-old male patient diagnosed with T-cell acute lymphoblastic leukemia underwent allogeneic stem cell transplantation. | 25472557 |
| Psoriasis | Stem Cell Exhaustion | Generalized pustular psoriasis following allogeneic stem cell transplantation. | 25472781 |
| Psoriasis | Stem Cell Exhaustion | Development of psoriasis following allogeneic stem cell transplantation (SCT) is rare, and has been described once previously, following SCT from a sibling donor with psoriasis. | 25472781 |
| Neurofibromatoses | Stem Cell Exhaustion | Proposing the use of dental pulp stem cells as a suitable biological model of neurofibromatosis type 1. | 25480698 |
| Neurofibromatoses | Stem Cell Exhaustion | This study aims to propose the dental pulp stem cells (DPSCs) as a model for studying two features related to neurofibromatosis type 1 (NF1), i.e. | 25480698 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | Determinants of neointimal proliferation and stent coverage after intracoronary therapy with drug-eluting devices in stable coronary artery disease: role of endothelial progenitor cells and interleukin-1 family cytokines. | 25480994 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | A cytogenetic model predicts relapse risk and survival in patients with acute myeloid leukemia undergoing hematopoietic stem cell transplantation in morphologic complete remission. | 25481050 |
| Alopecia, Cataract | Stem Cell Exhaustion | Broad induction at weaning inhibited proliferation of intestinal transit-amplifying and Lgr5+ stem cells and rapidly imposed features of aging, including hair loss, skin wrinkling, reduced body weight and subcutaneous fat, an increased myeloid fraction in peripheral blood, poor dentition, and cataracts. | 25481981 |
| Graft-vs-Host Disease, Stomatitis | Stem Cell Exhaustion | Mammalian target of rapamycin inhibitor-associated stomatitis in hematopoietic stem cell transplantation patients receiving sirolimus prophylaxis for graft-versus-host disease. | 25482865 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | The mammalian target of rapamycin (mTOR) inhibitor sirolimus is effective in reducing incidence of graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). | 25482865 |
| diabetic | Stem Cell Exhaustion | Short-term statin discontinuation increases endothelial progenitor cells without inflammatory rebound in type 2 diabetic patients. | 25483979 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Type 2 diabetes (T2D) is characterized by impaired vascular regeneration owing to reduced endothelial progenitor cells (EPCs). | 25483979 |
| Kidney Diseases | Stem Cell Exhaustion | BK virus nephropathy in a pediatric patient after hematopoietic stem cell transplantation. | 25484248 |
| Nephroblastoma, Acute lymphocytic leukemia | Stem Cell Exhaustion | A 15-year-old girl with acute lymphoblastic leukemia received allogeneic dendritic cell vaccination, pulsed with Wilms tumor 1 (WT1) peptide, after her third hematopoietic stem cell transplantation (HSCT). | 25484308 |
| Splenomegaly | Stem Cell Exhaustion | These patients may develop splenomegaly and require splenectomy to alleviate mechanical symptoms, to ameliorate transfusion-dependent cytopenias, or to enhance stem cell transplantation. | 25488568 |
| Fibrosis Assessment | Stem Cell Exhaustion | In a mouse model of liver fibrosis, systemic injection of bone marrow mesenchymal stem cells (BM-MSCs) was considered to rescue the diseased phenotype. | 25490388 |
| Fibrosis Assessment | Stem Cell Exhaustion | Therapeutic potential of human adipose tissue-derived multi-lineage progenitor cells in liver fibrosis. | 25490388 |
| Fibrosis Assessment | Stem Cell Exhaustion | The aim of this study was to assess the effectiveness of human adipose tissue-derived multi-lineage progenitor cells (hADMPCs) in improving liver fibrosis. | 25490388 |
| Hodgkin Disease | Stem Cell Exhaustion | [Treatment and prognosis of relapsed or refractory Hodgkin lymphoma patients ineligible for stem cell transplantation]. | 25493581 |
| LIPC gene | Stem Cell Exhaustion | Currently, there is no widely accepted standard treatment strategy in relapsed/refractory HL patients ineligible for autologous stem cell transplantation (ASCT). | 25493581 |
| Refractory Disease, Cardiotoxicity | Stem Cell Exhaustion | High-dose chemotherapy and ASCT was not indicated due to advanced age (seven patients), chemorefractory disease (seven patients), cardiotoxicity (two patients) and insufficient stem cell collection of CD34+ cells (one patient). | 25493581 |
| Granulocyte-Macrophage Progenitor Cells, Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | This phase I/II study assessed the safety, immunity and clinical response to 6 or 12 bi-weekly intradermal ImMucin vaccines, co-administered with human granulocyte-macrophage colony-stimulating factor to 15 MUC1-positive multiple myeloma (MM) patients, with residual or biochemically progressive disease following autologous stem cell transplantation. | 25496030 |
| Bacterial Infections | Stem Cell Exhaustion | Increased bacterial infections after transfusion of leukoreduced non-irradiated blood products in recipients of allogeneic stem cell transplants after reduced-intensity conditioning. | 25498924 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Blood components transfused to hematopoietic stem cell transplant (HSCT) recipients are irradiated to prevent transfusion-associated graft-versus-host disease (TA-GVHD). | 25498924 |
| Dyskeratosis Congenita | Stem Cell Exhaustion | Bone marrow skeletal stem/progenitor cell defects in dyskeratosis congenita and telomere biology disorders. | 25499762 |
| Colorectal Carcinoma | Stem Cell Exhaustion | Meanwhile, SIRT1 expression had a co-localization with CD133, a current universal marker to characterize colorectal cancer stem cells (CSCs). | 25500546 |
| B-Cell Lymphomas | Stem Cell Exhaustion | Fatal visceral varicella-zoster developing early after autologous hematopoietic stem cell transplantation for refractory diffuse large B-cell lymphoma. | 25501115 |
| Lymphoma | Stem Cell Exhaustion | A middle-aged woman who had undergone autologous hematopoietic stem cell transplantation (HSCT) 1 month previously suffered severe epigastralgia and relapse of lymphoma. | 25501115 |
| Specialty Type - cancer | Stem Cell Exhaustion | Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility, and tropism to brain cancer. | 25501828 |
| Sarcopenia | Stem Cell Exhaustion | Although the etiology of sarcopenia is unknown, the correlation during aging between the loss of activity of satellite cells, which are endogenous muscle stem cells, and impaired muscle regenerative capacity has led to the hypothesis that the loss of satellite cell activity is also a cause of sarcopenia. | 25501907 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Autologous stem cell transplantation with in vivo purged progenitor cells shows long-term efficacy in relapsed/refractory follicular lymphoma. | 25502635 |
| Lymphoma, Follicular | Stem Cell Exhaustion | High-dose chemotherapy with autologous stem cell transplantation (ASCT) has been shown effective in the control of relapsed/refractory follicular lymphoma. | 25502635 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | Genome-wide association studies revealed a link between gastric cancer (GC) and single nucleotide polymorphisms (SNPs) of prostate stem cell antigen (PSCA), phospholipase C epsilon-1 (PLCE1) and mucin-1 (MUC1) genes. | 25503145 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | Polaprezinc prevents oral mucositis in patients treated with high-dose chemotherapy followed by hematopoietic stem cell transplantation. | 25503160 |
| Hematologic Neoplasms, Gastrointestinal mucositis | Stem Cell Exhaustion | The present study was designed to investigate whether P-AG prevents oral mucositis in all patients (36 patients) with hematological malignancy receiving high-dose chemotherapy and radiotherapy followed by hematopoietic stem cell transplantation (HSCT). | 25503160 |
| Secondary malignant neoplasm of liver | Stem Cell Exhaustion | Portal vein embolisation with application of haematopoietic stem cells in patients with primarily or non-resectable colorectal liver metastases. | 25503161 |
| Dyspnea, CTCAE, Fever | Stem Cell Exhaustion | Dyspnea and fever in an allogeneic stem cell recipient. | 25504499 |
| Hypoxia | Stem Cell Exhaustion | Data showed that chemical-induced hypoxia changed cell stemness by enhancing stem cell transcription factors and markers of chemotherapeutic drug resistance. | 25512094 |
| Specialty Type - cancer | Stem Cell Exhaustion | The CD166-positive cancer stem cell-like population showed greater drug resistance than the CD166-negative cells. | 25512094 |
| Behavior, Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | Since cancer stem cells exhibit embryonic-like self-renewal characteristics and malignant behavior, including drug resistance and metastasis, they may be the origin of tumorigenesis and cancer recurrence. | 25512094 |
| Specialty Type - cancer, Hypoxia | Stem Cell Exhaustion | Our findings indicate that chemical hypoxia may augment cancer cell stemness and drug resistance in CD166-positive stem cells. | 25512094 |
| Anemia, PAFAH1B1 wt Allele, Dysplasia, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | tet2(m/m) (homozygous for the mutation) zebrafish exhibited normal embryonic and larval hematopoiesis but developed progressive clonal myelodysplasia as they aged, culminating in myelodysplastic syndromes (MDS) at 24 months of age, with dysplasia of myeloid progenitor cells and anemia with abnormal circulating erythrocytes. | 25512612 |
| PAFAH1B1 wt Allele, Malignant Neoplasms, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Somatic loss-of-function mutations of TET2 are frequently observed in human myelodysplastic syndrome (MDS), which is a clonal malignancy characterized by dysplastic changes of developing blood cell progenitors, leading to ineffective hematopoiesis. | 25512612 |
| Autoimmune Diseases, Autoimmune state | Stem Cell Exhaustion | While autoimmune disease can occur after solid organ and stem cell transplant, our patient developed skin manifestations of autoimmunity after liver transplantation, which is also rarely described. | 25516432 |
| Tuberculosis | Stem Cell Exhaustion | Long-term risk of tuberculosis in haematopoietic stem cell transplant recipients: a 10-year nationwide study. | 25519791 |
| Tuberculosis | Stem Cell Exhaustion | Tuberculosis (TB) is a serious problem for patients undergoing haematopoietic stem cell transplantation (HSCT) in TB-endemic areas; however, data on these patients are limited. | 25519791 |
| Aplastic Anemia, Peritonitis | Stem Cell Exhaustion | We report the case of an 11-year-old girl with aplastic anemia on ambulatory peritoneal dialysis who had Mycobacterium avium complex-associated peritonitis after allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 25521993 |
| leukemia | Stem Cell Exhaustion | In a multicentre, single-arm, open-label phase 2 study, we enrolled adult patients with Philadelphia-chromosome-negative, primary refractory or relapsed (first relapse within 12 months of first remission, relapse within 12 months after allogeneic haemopoietic stem-cell transplantation [HSCT], or no response to or relapse after first salvage therapy or beyond) leukaemia. | 25524800 |
| Neoplasms | Stem Cell Exhaustion | Isolated cells, both from GH(+) and NS tumors, satisfy all the criteria for the identification of PMCs and express known stem cell markers (OCT4, SOX2, KLF4, NANOG), but do not express markers of pituitary hormone cell types (PITX2, PROP1, PIT1). | 25525036 |
| Pituitary Neoplasms, Neoplasms | Stem Cell Exhaustion | We demonstrated that pituitary tumors contain a stem cell population that can generate cell types characteristic of mesenchymal stem cells, and express CD133, which is associated with CSCs in other tumors. | 25525036 |
| Specialty Type - cancer | Stem Cell Exhaustion | The Cancer Stem Cells (CSCs) theory suggests that genetic alterations in stem cells are the direct cause for cancer. | 25525036 |
| Heart failure | Stem Cell Exhaustion | Atorvastatin treatment improves endothelial function through endothelial progenitor cells mobilization in ischemic heart failure patients. | 25525743 |
| Drug-Induced Ototoxicity | Stem Cell Exhaustion | Emerging hepatic models for the study of drug-induced toxicity include pluripotent stem cell-derived hepatocyte-like cells (HLCs) and complex hepatocyte-non-parenchymal cellular coculture to mimic the complex multicellular interactions that recapitulate the niche environment in the human liver. | 25527335 |
| Toxic effect, Drug-Induced Ototoxicity | Stem Cell Exhaustion | In this study, we demonstrate that microRNA-122 (miR-122) detection in cell culture media can be used as a hepatocyte-enriched in vitro marker of drug-induced toxicity in homogeneous cultures of hepatic cells, and a cell-specific marker of toxicity of hepatic cells in heterogeneous cultures such as HLCs generated from various differentiation protocols and pluripotent stem cell lines, where conventional cytotoxicity assays using generic cellular markers may not be appropriate. | 25527335 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | Tyrosine kinase inhibitors improve long-term outcome of allogeneic hematopoietic stem cell transplantation for adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia. | 25527562 |
| B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 | Stem Cell Exhaustion | This study aimed to determine the impact of tyrosine kinase inhibitors given pre- and post-allogeneic stem cell transplantation on long-term outcome of patients allografted for Philadelphia chromosome-positive acute lymphoblastic leukemia. | 25527562 |
| leukemia, B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 | Stem Cell Exhaustion | This retrospective analysis from the EBMT Acute Leukemia Working Party included 473 de novo Philadelphia chromosome-positive acute lymphoblastic leukemia patients in first complete remission who underwent an allogeneic stem cell transplantation using a human leukocyte antigen-identical sibling or human leukocyte antigen-matched unrelated donor between 2000 and 2010. | 25527562 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | Over the past decade, administration of tyrosine kinase inhibitors before allogeneic stem cell transplantation has significantly improved the long-term allogeneic stem cell transplantation outcome of adult Philadelphia chromosome-positive acute lymphoblastic leukemia. | 25527562 |
| Varicella Zoster Encephalitis | Stem Cell Exhaustion | Varicella zoster virus encephalomyelitis as a late complication following haematopoietic stem cell transplantation. | 25527690 |
| Multiple Myeloma | Stem Cell Exhaustion | The patient had a history of multiple myeloma diagnosed 2 years earlier, treated with chemotherapy and autologous stem cell transplant. | 25527690 |
| herpesvirus 3, human | Stem Cell Exhaustion | VZV should be considered in patients with haematopoietic stem cell transplantation presenting with similar neurological manifestations even in the absence of dermatological signs. | 25527690 |
| Acute GVH disease | Stem Cell Exhaustion | High number of memory t cells is associated with higher risk of acute graft-versus-host disease after allogeneic stem cell transplantation. | 25528387 |
| Chronic graft-versus-host disease | Stem Cell Exhaustion | We previously reported a risk score that predicted mortality in patients with chronic graft-versus-host disease (CGVHD) after hematopoietic stem cell transplantation (HCT) between 1995 and 2004 and reported to the Center for International Blood and Marrow Transplant Research (CIBMTR). | 25528390 |
| Respiratory Distress Syndrome, Adult | Stem Cell Exhaustion | The STem cells for ARDS Treatment (START) trial was a multicentre, open-label, dose-escalation, phase 1 clinical trial. | 25529339 |
| Multiple Myeloma | Stem Cell Exhaustion | Second autologous stem cell transplant: an effective therapy for relapsed multiple myeloma. | 25529381 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Therapeutic options for patients with multiple myeloma (MM) whose disease has relapsed after a prior autologous stem cell transplant (ASCT) include an expanding armamentarium of novel agents, often combined with traditional chemotherapy, or a second ASCT, with no clear standard of care. | 25529381 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Comparison of unrelated cord blood and peripheral blood stem cell transplantation in adults with myelodysplastic syndrome after reduced-intensity conditioning regimen: a collaborative study from Eurocord (Cord blood Committee of Cellular Therapy & Immunobiology Working Party of EBMT) and Chronic Malignancies Working Party. | 25529382 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (HSCT) remains the only curative treatment in patients with higher risk myelodysplastic syndrome (MDS), but the choice of the optimal alternative stem cell source is still a subject of debate in patients lacking an HLA-matched sibling donor. | 25529382 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | Here, we report on a large series of patients with MDS (N = 631) transplanted either with mobilized peripheral stem cells (PBs) from unrelated donors (n = 502) or with umbilical cord blood transplant (UCB, n = 129) as alternative grafts after reduced-intensity conditioning. | 25529382 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | We conclude that in MDS patients lacking an HLA-matched sibling donor, PB from a 10/10 HLA-matched unrelated donor is the preferred source of hematopoietic stem cells. | 25529382 |
| Multiple Myeloma | Stem Cell Exhaustion | Changing trends in prognostic factors for patients with multiple myeloma after autologous stem cell transplantation during the immunomodulator drug/proteasome inhibitor era. | 25530023 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | We evaluated the clinical significance of prognostic factors including the International Staging System (ISS) and modified European Group for Blood and Marrow Transplantation response criteria in 1650 Japanese patients with multiple myeloma (MM) who underwent upfront single autologous stem cell transplantation (ASCT). | 25530023 |
| Up | Stem Cell Exhaustion | Specifically, neural stem cell transplantation as a treatment for AD offers a novel approach with tremendous therapeutic potential. | 25530343 |
| Neurodegenerative Disorders | Stem Cell Exhaustion | These promising findings prompted us to examine a human neural stem cell population, HuCNS-SC, which has already been clinically tested for other neurodegenerative disorders. | 25530343 |
| Alzheimers Disease", Neuronal loss in central nervous system | Stem Cell Exhaustion | Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss. | 25530343 |
| Impaired cognition | Stem Cell Exhaustion | Over the last decade, the potential use of stem cells to treat cognitive impairment has received growing attention. | 25530343 |
| Neuronal loss in central nervous system | Stem Cell Exhaustion | We previously reported that intrahippocampal transplantation of murine neural stem cells (mNSCs) can enhance synaptogenesis and improve cognition in 3xTg-AD mice and the CaM/Tet-DT(A) model of hippocampal neuronal loss. | 25530343 |
| Intrinsic Factor Deficiency | Stem Cell Exhaustion | Recurrence of IFD after chemotherapy or hematopoietic stem cell transplantation (HSCT) is associated with poor prognosis. | 25531544 |
| Hodgkin Disease | Stem Cell Exhaustion | We present response and survival outcomes of a pivotal phase 2 trial of the antibody-drug conjugate brentuximab vedotin in patients with relapsed/refractory Hodgkin lymphoma following autologous stem cell transplant (N = 102) after a median observation period of approximately 3 years. | 25533035 |
| Lupus Vulgaris | Stem Cell Exhaustion | Differential expression of the transcription factor ARID3a in lupus patient hematopoietic progenitor cells. | 25535283 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | CD90 (Thy-1) plays important roles in oncogenesis and shows potential as a candidate marker for cancer stem cells (CSCs) in various malignancies. | 25536077 |
| Hepatitis | Stem Cell Exhaustion | Transient grades 3 to 4 acute hepatitis is a common complication of rabbit antithymocyte globulin (thymoglobulin) administered before allogeneic stem cell transplantation. | 25536216 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | By promoting cell differentiation, miR-100 sensitizes basal-like breast cancer stem cells to hormonal therapy. | 25537513 |
| Neoplasms, Childhood Breast Carcinoma | Stem Cell Exhaustion | Tumor formation and relapse are sustained by a cell subset of Breast Cancer Stem Cells (BrCSCs). | 25537513 |
| S100A4 protein, human | Stem Cell Exhaustion | The authors characterized human adipose-derived stem cells at different in vitro culture time points in terms of immunophenotype, multilineage differentiation, long-term survival with self-renewal capacity, and presence of telomere maintenance mechanisms (telomerase activity and alternative lengthening of telomere) for excluding their eventual susceptibility to malignant transformation. | 25539318 |
| S100A4 protein, human | Stem Cell Exhaustion | The results support the concept that in vitro expanded adipose-derived stem cells obtained from fat tissue are not susceptible to developing one of the hallmarks of malignant transformation and can be considered amenable for cell therapy approaches. | 25539318 |
| Cessation of life, HD Term Type | Stem Cell Exhaustion | Small-molecule ATM inhibitors reduced mHTT-induced death of rat striatal neurons and induced pluripotent stem cells derived from HD patients. | 25540325 |
| Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Treatment of acute myeloid leukemia or myelodysplastic syndrome relapse after allogeneic stem cell transplantation with azacitidine and donor lymphocyte infusions--a retrospective multicenter analysis from the German Cooperative Transplant Study Group. | 25540937 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute, MYELOPROLIFERATIVE SYNDROME, TRANSIENT | Stem Cell Exhaustion | To expand the current knowledge about azacitidine (Aza) and donor lymphocyte infusions (DLI) as salvage therapy for relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and to identify predictors for response and survival, we retrospectively analyzed data of 154 patients with acute myeloid leukemia (AML, n = 124), myelodysplastic (MDS, n = 28), or myeloproliferative syndrome (n = 2). | 25540937 |
| TCL4 gene, Aggressive course | Stem Cell Exhaustion | A retrospective analysis of treatment outcomes in adult T cell leukemia/lymphoma patients with aggressive disease treated with or without allogeneic stem cell transplantation: A single-center experience. | 25542158 |
| TRPV6 wt Allele | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been reported as a curative treatment modality for ATL. | 25542158 |
| Hemopoietic stem cell transplant | Stem Cell Exhaustion | The aim of this study was to assess the prevalence of PDDIs that occur in HSCT patients on the day of hematopoietic stem cell infusion. | 25542268 |
| Viral respiratory infection | Stem Cell Exhaustion | Community respiratory virus infection in hematopoietic stem cell transplantation recipients and household member characteristics. | 25542323 |
| Atherosclerosis, Dental Plaque, Ischemic stroke | Stem Cell Exhaustion | The relationships between the number of circulating endothelial cells (CECs) or endothelial progenitor cells (EPCs) and indicators of carotid atherosclerosis, such as the intima-media thickness (IMT) and plaque score are not well characterized in patients with chronic ischemic stroke. | 25542764 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | In this study, the role of T cells expressing CD161 as a predictor for the occurrence of acute graft-versus-host disease (aGVHD) after allogeneic stem cell transplantation (SCT) was investigated. | 25543092 |
| Acute Cholecystitis | Stem Cell Exhaustion | Acute cholecystitis is a common complication after allogeneic stem cell transplantation and is associated with the use of total parenteral nutrition. | 25543093 |
| Acute Cholecystitis, Allogeneic Hematopoietic Stem Cell Transplantation | Stem Cell Exhaustion | The incidence and risk factors for acute cholecystitis after allogeneic hematopoietic stem cell transplantation (HSCT) are not well defined. | 25543093 |
| Chemotherapy-Induced Febrile Neutropenia | Stem Cell Exhaustion | One hundred seventy consecutive patients with a recent history of chemotherapy-induced neutropenia (n = 100) or allogeneic stem cell recipients (n = 70) who had received a CT scan of the chest in search of pulmonary IFD were examined. | 25544029 |
| Pseudomonas aeruginosa, Communicable Diseases | Stem Cell Exhaustion | Fecal colonization and infection with Pseudomonas aeruginosa in recipients of allogeneic hematopoietic stem cell transplantation. | 25546740 |
| Pseudomonas aeruginosa | Stem Cell Exhaustion | Pseudomonas aeruginosa, especially multidrug-resistant (MDR) isolates, is an important pathogen in allogeneic hematopoietic stem cell transplant (HCT) recipients. | 25546740 |
| Neoplasms, Angiomyofibroblastoma | Stem Cell Exhaustion | Thus, our case of angiomyofibroblastoma is an example of tumor that probably derives from perivascular stem cells that acquire some of myoid features. | 25546934 |
| Neoplasms | Stem Cell Exhaustion | Myeloid-derived suppressor cells (MDSCs) are heterogeneous, immature, myeloid progenitor cells, which suppress immune responses against tumors. | 25548095 |
| Thrombasthenia | Stem Cell Exhaustion | Use of allogeneic stem cell transplantation for moderate-severe Glanzmann thrombasthenia. | 25548835 |
| Specialty Type - cancer, Colorectal Carcinoma, Neoplasms | Stem Cell Exhaustion | Cancer stem cell marker in circulating tumor cells: expression of CD44 variant exon 9 is strongly correlated to treatment refractoriness, recurrence and prognosis of human colorectal cancer. | 25550556 |
| Colorectal Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | The expression of the CD44 variant exon 9 (CD44v9) was investigated in order to elucidate its significance for cancer stem cells in circulating human colorectal cancer cells (CTCs). | 25550556 |
| MYELODYSPLASTIC SYNDROME, Secondary Acute Myeloid Leukemia | Stem Cell Exhaustion | Impact of the revised International Prognostic Scoring System, cytogenetics and monosomal karyotype on outcome after allogeneic stem cell transplantation for myelodysplastic syndromes and secondary acute myeloid leukemia evolving from myelodysplastic syndromes: a retrospective multicenter study of the European Society of Blood and Marrow Transplantation. | 25552702 |
| MYELODYSPLASTIC SYNDROME, Secondary Acute Myeloid Leukemia | Stem Cell Exhaustion | The aim of this study was to determine the impact of the revised 5-group International Prognostic Scoring System cytogenetic classification on outcome after allogeneic stem cell transplantation in patients with myelodysplastic syndromes or secondary acute myeloid leukemia who were reported to the European Society for Blood and Marrow Transplantation database. | 25552702 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | The revised International Prognostic Scoring System cytogenetic classification allows patients with myelodysplastic syndromes to be separated into three groups with clearly different outcomes after stem cell transplantation. | 25552702 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | These phase I data support the safety of stromal stem cell therapy and suggest that MAPC should be tested prospectively as a novel therapeutic option for GVHD prophylaxis after HCT. | 25555450 |
| Acute GVH disease | Stem Cell Exhaustion | Single and multiple dose MultiStem (multipotent adult progenitor cell) therapy prophylaxis of acute graft-versus-host disease in myeloablative allogeneic hematopoietic cell transplantation: a phase 1 trial. | 25555450 |
| Neoplasms | Stem Cell Exhaustion | The druggable orphan nuclear receptor TLX (NR2E1) is characterized as an important regulator of neural stem cells and is also implicated in the development of some brain tumours. | 25557355 |
| Adult Glioblastoma | Stem Cell Exhaustion | Immunophenotypic characterization of human glioblastoma stem cells: correlation with clinical outcome. | 25559650 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Recently, glioma stem cells have been identified as the main cause of glioma propagation and recurrence and a number of several cell markers have been indicated as putative GSC markers. | 25559650 |
| Adult Glioblastoma | Stem Cell Exhaustion | b-tubulin III, nestin, CD133, GFAP, and SOX-2 marker expression, both in primary GBM cultures and in respective glioblastoma stem cells (GSCs), was evaluated by flow cytometric analysis. | 25559650 |
| hepatitis B virus, Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Circulating tumor and cancer stem cells in hepatitis C virus-associated liver disease. | 25561791 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | To assess the role of circulating tumor cells (CTCs) and cancer stem cells (CSCs) in hepatitis C virus (HCV)-associated liver disease. | 25561791 |
| Leukemia, Myelocytic, Acute, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Granulocyte colony-stimulating factor-primed bone marrow: an excellent stem-cell source for transplantation in acute myelocytic leukemia and chronic myelocytic leukemia. | 25563308 |
| Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Autologous stem cell transplant (ASCT) after high-dose chemotherapy (HDT) increases overall survival when used in relapsed non-Hodgkin lymphoma (NHL) in patients under 65 years old. | 25563428 |
| Carcinogenesis | Stem Cell Exhaustion | Current models of carcinogenesis are dominated by the assumption that oncogenic mutations have defined advantageous fitness effects on recipient stem and progenitor cells, promoting and rate-limiting somatic evolution. | 25564763 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | The outcomes of unrelated stem cell transplantation (SCT) have improved with the use of anti-thymocyte globulin (ATG) to prevent graft-versus-host disease (GVHD) and graft rejection. | 25564881 |
| Mastocytosis | Stem Cell Exhaustion | Molecular profiling of myeloid progenitor cells in multi-mutated advanced systemic mastocytosis identifies KIT D816V as a distinct and late event. | 25567135 |
| Mastocytosis | Stem Cell Exhaustion | To explore the molecular profile and its prognostic implication in systemic mastocytosis (SM), we analyzed the mutation status of granulocyte-macrophage colony-forming progenitor cells (CFU-GM) in patients with KIT D816V(+) indolent SM (ISM, n=4), smoldering SM (SSM, n=2), aggressive SM (ASM, n=1), SM with associated clonal hematologic non-mast cell lineage disorder (SM-AHNMD, n=5) and ASM-AHNMD (n=7). | 25567135 |
| Ischemia | Stem Cell Exhaustion | Effect of repetitive intra-arterial infusion of bone marrow mononuclear cells in patients with no-option limb ischemia: the randomized, double-blind, placebo-controlled Rejuvenating Endothelial Progenitor Cells via Transcutaneous Intra-arterial Supplementation (JUVENTAS) trial. | 25567765 |
| Ischemia | Stem Cell Exhaustion | The Rejuvenating Endothelial Progenitor Cells via Transcutaneous Intra-arterial Supplementation (JUVENTAS) trial is a randomized, double-blind, placebo-controlled clinical trial in 160 patients with severe, nonrevascularizable limb ischemia. | 25567765 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | R-MPV followed by high-dose chemotherapy with TBC and autologous stem-cell transplant for newly diagnosed primary CNS lymphoma. | 25568347 |
| Encephalopathy, CTCAE 5.0 | Stem Cell Exhaustion | An 18-month-old boy developed encephalopathy, for which extensive investigation failed to identify an etiology, 6 weeks after stem cell transplant. | 25572899 |
| Multiple Myeloma | Stem Cell Exhaustion | A Phase II trial of weekly bortezomib and dexamethasone in veterans with newly diagnosed multiple myeloma not eligible for or who deferred autologous stem cell transplantation. | 25572917 |
| Multiple Myeloma | Stem Cell Exhaustion | We report a phase II trial of alternate dosing and schedule of bortezomib and dexamethasone in newly diagnosed multiple myeloma patients who are not eligible for or refused autologous stem cell transplantation. | 25572917 |
| Dislocations | Stem Cell Exhaustion | It is hypothesized to result from the dislocation of small osseous fragments from the xiphoid or os pubis as well as from osteogenic differentiation of local mesenchymal progenitor cells. | 25572973 |
| Multiple Myeloma | Stem Cell Exhaustion | Absolute lymphocyte count as predictor of overall survival for patients with multiple myeloma treated with single autologous stem cell transplant. | 25573201 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Post-autologous stem cell transplant (ASCT) studies have demonstrated that absolute lymphocyte count (ALC) recovery is associated with prolonged survival in some hematological malignancies. | 25573201 |
| Ischemia | Stem Cell Exhaustion | Epigenetic profile of human adventitial progenitor cells correlates with therapeutic outcomes in a mouse model of limb ischemia. | 25573856 |
| Ischemia | Stem Cell Exhaustion | We investigated the association between the functional, epigenetic, and expressional profile of human adventitial progenitor cells (APCs) and therapeutic activity in a model of limb ischemia. | 25573856 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Causes of discontinuation were disease transformation (7), progressive CLL (7), stem cell transplantation (3), adverse events (11), serious adverse events/deaths (3), and miscellaneous reasons (2). | 25573991 |
| Cardiac complication | Stem Cell Exhaustion | Levels of the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) are elevated and endothelial progenitor cells (EPCs) decreased in patients undergoing renal transplantation (Tx) and may contribute to cardiovascular complications. | 25576240 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Beta-2 microglobulin predicts the outcome after autologous stem cell transplantation in non-Hodgkin lymphoma. | 25577449 |
| Lymphoma | Stem Cell Exhaustion | Autologous stem cell transplantation (ASCT) is an established therapeutic modality in the treatment of lymphomas, especially in the relapse setting. | 25577449 |
| Allogeneic Hematopoietic Stem Cell Transplantation, Infection of bloodstream | Stem Cell Exhaustion | Risk factors for pre- and post-engraftment bloodstream infections after allogeneic hematopoietic stem cell transplantation. | 25580541 |
| Behavioral Symptoms Index Composite Score (BASC-2), Infection of bloodstream | Stem Cell Exhaustion | Bloodstream infections (BSI) are frequently observed after allogeneic hematopoietic stem cell transplant (HSCT), and could cause morbidity and mortality. | 25580541 |
| Neoplasms | Stem Cell Exhaustion | Metabolite profiles of 42 GSC lines established from the tumor tissue of adult GBM patients were screened with (1) H NMR spectroscopy and compared with human neural progenitor cells from human adult olfactory bulb (OB-NPCs) and from the developing human brain (HNPCs). | 25581615 |
| NCI CTEP SDC AIDS-related Lymphoma Sub-Category Terminology | Stem Cell Exhaustion | Autograft HIV-DNA load predicts HIV-1 peripheral reservoir after stem cell transplantation for AIDS-related lymphoma patients. | 25581618 |
| HIV-1 Infection Pathway, Lymphoma | Stem Cell Exhaustion | Autologous stem cell transplantation (ASCT) is a widely used procedure for AIDS-related lymphomas, and it represents an opportunity to evaluate strategies curing HIV-1 infection. | 25581618 |
| Toxoplasmosis, Cerebral | Stem Cell Exhaustion | Cerebral toxoplasmosis in an adolescent post allogeneic hematopoietic stem cell transplantation: successful outcome by antiprotozoal chemotherapy and CD4+ T-lymphocyte recovery. | 25581774 |
| Opportunistic Infections, T-lymphocyte deficiency, Toxoplasmosis | Stem Cell Exhaustion | Toxoplasmosis is a rare opportunistic infection in pediatric allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients and associated with severe T-cell deficiency. | 25581774 |
| Childhood Non-Hodgkin Lymphoma, Toxoplasmosis, Cerebral | Stem Cell Exhaustion | Here, we report the successful management of cerebral toxoplasmosis in a 15-year-old adolescent 4 months post allo-HSCT for non-Hodgkin lymphoma through rapid invasive diagnostics, long-term antiprotozoal chemotherapy, and an hematopoietic stem cell boost for persistently poor graft function. | 25581774 |
| Helicobacter-associated gastritis | Stem Cell Exhaustion | Influence of prostate stem cell antigen gene polymorphisms on susceptibility to Helicobacter pylori-associated diseases: a case-control study. | 25582162 |
| Duodenal Ulcer, Malignant neoplasm of stomach | Stem Cell Exhaustion | Recently, the prostate stem cell antigen (PSCA) rs2294008 C>T polymorphism was found to be associated with different pathogenesis of duodenal ulcer and gastric cancer developments. | 25582162 |
| Trichoepithelioma | Stem Cell Exhaustion | The follicular germinative cells observed in the papillary projections and in the aggregations of trichoblastoma expressed cytokeratin-15 (clone C8/144B) and PHLDA1, markers of follicular stem cells. | 25583250 |
| TCL6 gene, Specialty Type - cancer | Stem Cell Exhaustion | Similar changes were noted across all cancer types, with highest rates of immunization in leukemia/lymphoma patients (86.8%) and lowest in patients after stem cell transplant (66.7%). | 25583919 |
| Colorectal Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Aldehyde dehydrogenase 1: a specific cancer stem cell marker for human colorectal carcinoma. | 25585687 |
| Colorectal Carcinoma, Cytogenetic Complete Response | Stem Cell Exhaustion | According to the stem cell (SC) theory, colorectal carcinoma (CRC) SCs may be derived from mutations in normal intestinal cells. | 25585687 |
| Cytogenetic Complete Response | Stem Cell Exhaustion | Thus, through a shared stem cell marker between CSCs and SCs, it is possible to investigate the association between its expression and the various clinicopathological features in patients with CRC. | 25585687 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Since the identification of cancer stem cells (CSCs) a new understanding of tumor occurrence and development has evolved. | 25585687 |
| B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative | Stem Cell Exhaustion | Role of allogeneic stem cell transplantation in adult patients with Ph-negative acute lymphoblastic leukemia. | 25587040 |
| leukemia, BCR gene | Stem Cell Exhaustion | Because a pediatric-inspired Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) protocol yielded a markedly improved outcome in adults with Philadelphia chromosome-negative ALL, we aimed to reassess the role of allogeneic stem cell transplantation (SCT) in patients treated in the GRAALL-2003 and GRAALL-2005 trials. | 25587040 |
| Acute lymphocytic leukemia, Intrinsic Factor Deficiency, Mycoses, BCR gene | Stem Cell Exhaustion | Patients with acute lymphoblastic leukaemia (ALL) after cytotoxic chemotherapy or haematopoietic stem cell transplantation (HSCT) are at risk for life-threatening invasive fungal disease (IFD). | 25590660 |
| Cardiomyopathy, Familial Idiopathic | Stem Cell Exhaustion | Autologous transplantation of bone marrow adult stem cells for the treatment of idiopathic dilated cardiomyopathy. | 25590932 |
| Mitral Valve Insufficiency, Cardiomyopathy, Familial Idiopathic | Stem Cell Exhaustion | Determine the effectiveness of autologous transplantation of bone marrow adult stem cells on systolic and diastolic left ventricular function, and on the degree of mitral regurgitation in patients with dilated idiopathic cardiomyopathy in functional classes NYHA II and III. | 25590932 |
| Cardiomyopathy, Familial Idiopathic | Stem Cell Exhaustion | We administered 4,54 x 10(8) +- 0,89 x 10(8) bone marrow adult stem cells into the coronary arteries of 24 patients with dilated idiopathic cardiomyopathy in functional classes NYHA II and III. | 25590932 |
| Ischemic cardiomyopathy | Stem Cell Exhaustion | Effect of aging on human mesenchymal stem cell therapy in ischemic cardiomyopathy patients. | 25593053 |
| Ischemic cardiomyopathy, between breakfast and lunch | Stem Cell Exhaustion | The role of patient age in the efficacy of mesenchymal stem cell (MSC) therapy in ischemic cardiomyopathy (ICM) is controversial. | 25593053 |
| Heart failure, between breakfast and lunch | Stem Cell Exhaustion | Patients with ICM who received MSCs via transendocardial stem cell injection (TESI) as part of the TAC-HFT (Transendocardial Autologous Cells in Ischemic Heart Failure) (n = 19) and POSEIDON (Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis) (n = 30) clinical trials were divided into 2 age groups: younger than 60 and 60 years of age and older. | 25593053 |
| Cerebral Palsy | Stem Cell Exhaustion | Intrathecal injection of CD133-positive enriched bone marrow progenitor cells in children with cerebral palsy: feasibility and safety. | 25593079 |
| Multiple Myeloma | Stem Cell Exhaustion | A serum microRNA signature associated with complete remission and progression after autologous stem-cell transplantation in patients with multiple myeloma. | 25593199 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma, Gammopathy | Stem Cell Exhaustion | We have examined serum microRNA expression in multiple myeloma (MM) patients at diagnosis and at complete response (CR) after autologous stem-cell transplantation (ASCT), in patients with stable monoclonal gammopathy of undetermined significance, and in healthy controls. | 25593199 |
| Retinal Pigments | Stem Cell Exhaustion | Defined culture of human embryonic stem cells and xeno-free derivation of retinal pigmented epithelial cells on a novel, synthetic substrate. | 25593208 |
| Metabolic Syndrome X | Stem Cell Exhaustion | Aerobic exercise modulation of mental stress-induced responses in cultured endothelial progenitor cells from healthy and metabolic syndrome subjects. | 25596018 |
| Clostridium difficile enteritis | Stem Cell Exhaustion | C. difficile screening was performed on patients admitted for chemotherapy or haematopoietic stem cell transplantation between 2009 and 2013. | 25596117 |
| Central Diabetes Insipidus | Stem Cell Exhaustion | The incidence of CDI did not differ between patients receiving chemotherapy and those receiving haematopoietic stem cell transplantation. | 25596117 |
| Lymphoma | Stem Cell Exhaustion | For younger patients with relapsed or refractory lymphomas who respond to salvage therapy, autologous stem cell trans- plantation(ASCT)is the standard of care. | 25596679 |
| Ph-Like Acute Lymphoblastic Leukemia | Stem Cell Exhaustion | He had a history of BCR-ABL-positive acute lymphoblastic leukemia and had undergone an allogenic stem cell transplantation. | 25597932 |
| Colorectal Carcinoma | Stem Cell Exhaustion | Increased pre-surgical numbers of endothelial progenitor cells and circulating endothelial cells in colorectal cancer fail to predict outcome. | 25598043 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Allogeneic stem cell transplantation for refractory acute myeloid leukemia: a single center analysis of long-term outcome. | 25598394 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | For patients with refractory acute myeloid leukemia (AML), allogeneic stem cell transplantation (alloSCT) represents the only curative approach. | 25598394 |
| Sepsis | Stem Cell Exhaustion | Severe sepsis in hematopoietic stem cell transplant recipients*. | 25599465 |
| Infection, Immunocompromised Host | Stem Cell Exhaustion | Hematopoietic stem cell transplant recipients are more likely to be immunocompromised and are predisposed to serious infections. | 25599465 |
| Sepsis | Stem Cell Exhaustion | We compared outcomes of hematopoietic stem cell transplant recipients with severe sepsis during engraftment and subsequent admissions with a non-hematopoietic stem cell transplant cohort and excluded solid-organ transplantation from this cohort. | 25599465 |
| Sepsis | Stem Cell Exhaustion | We used mixed effect, multivariate logistic regression modeling with propensity score adjustment to examine factors associated with mortality of severe sepsis in hematopoietic stem cell transplant recipients. | 25599465 |
| Sepsis | Stem Cell Exhaustion | A total of 21,898 hematopoietic stem cell transplant recipients with severe sepsis were identified. | 25599465 |
| Sepsis | Stem Cell Exhaustion | The frequency of severe sepsis in hematopoietic stem cell transplant recipients was five times higher when compared with the non-hematopoietic stem cell transplant cohort. | 25599465 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | The unadjusted mortality was 32.9% in non-hematopoietic stem cell transplant cohort, which was similar to autologous hematopoietic stem cell transplant recipients (30.1%) and those who did not develop graft-versus-host disease (35%). | 25599465 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Similarly, in subsequent admissions, hematopoietic stem cell transplant recipients with graft-versus-host disease (odds ratio, 2.14; 95% CI, 1.88-2.45) and without graft-versus-host disease (odds ratio, 1.35; 95% CI, 1.19-1.54) had significantly higher odds of mortality than non-hematopoietic stem cell transplant patients. | 25599465 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Among patients with hematopoietic stem cell transplant, persons with autologous hematopoietic stem cell transplant and those without graft-versus-host disease fared better as compared with their allogeneic and graft-versus-host disease counterparts. | 25599465 |
| Sepsis | Stem Cell Exhaustion | Hematopoietic stem cell transplant recipients are more likely to develop severe sepsis and die following a severe sepsis episode than nontransplant patients. | 25599465 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplant recipients and those who do not develop graft-versus-host disease have significantly better outcomes than allogeneic and graft-versus-host disease patients. | 25599465 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Aldehyde dehydrogenase 1 (ALDH1) is a marker of breast cancer stem cells, and the expression of ALDH1 may be a prognostic factor of poor clinical outcome. | 25599843 |
| Hematopoietic Neoplasms, Bone Marrow, Extramedullary Hematopoiesis Function, Primary Myelofibrosis | Stem Cell Exhaustion | Myelofibrosis is a haematopoietic stem cell neoplasm characterized by bone marrow inflammation, reactive marrow fibrosis and extramedullary haematopoiesis. | 25601337 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Onset of ocular graft-versus-host disease symptoms after allogeneic hematopoietic stem cell transplantation. | 25603230 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | To study the factors affecting the time to onset of ocular graft-versus-host disease (GVHD) in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 25603230 |
| Retinal Pigments | Stem Cell Exhaustion | Canonical/b-catenin Wnt pathway activation improves retinal pigmented epithelium derivation from human embryonic stem cells. | 25604686 |
| Retinal Pigments | Stem Cell Exhaustion | The purpose of this study was to better understand the role canonical/b-catenin Wnt signaling plays in the differentiation of human embryonic stem cells (hESCs) into retinal pigmented epithelium (RPE), with the goal of improving methods for derivation. | 25604686 |
| Specialty Type - cancer | Stem Cell Exhaustion | Previous studies demonstrated that a subpopulation of cancer cells, which are CD133 positive (CD133+) feature higher invasive and metastatic abilities, are called cancer stem cells (CSCs). | 25605013 |
| Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Dysfunction of B cells that maintain homeostasis may play a role in the pathogenesis of chronic graft-versus-host disease (cGVHD) after allogeneic stem cell transplantation. | 25605369 |
| Birth Injuries, Hypoxia-Ischemia, Brain | Stem Cell Exhaustion | Brain hypoxia-ischemia is a human neonatal injury that is considered a candidate for stem cell therapy. | 25605487 |
| Hypoxia-Ischemia, Brain, Carotid artery occlusion | Stem Cell Exhaustion | The possible therapeutic potential of human umbilical cord blood (HUCB) stem cells was evaluated in 14-day-old rats subjected to the right common carotid occlusion, a model of neonatal brain hypoxia-ischemia. | 25605487 |
| Neurologic Deficits, Hypoxia-Ischemia, Brain | Stem Cell Exhaustion | The results show the potential of HUCB stem cells in reduction of neurologic deficits associated with neonatal hypoxia-ischemia. | 25605487 |
| Childhood Non-Hodgkin Lymphoma, Hereditary hemochromatosis | Stem Cell Exhaustion | We present a 64-year-old white man with non-Hodgkin lymphoma treated with high-dose chemotherapy and stem cell transplant that was subsequently diagnosed with hereditary hemochromatosis. | 25608173 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Cytokine expression patterns and mesenchymal stem cell karyotypes from the bone marrow microenvironment of patients with myelodysplastic syndromes. | 25608238 |
| PAFAH1B1 wt Allele, Cessation of life, Stem Cell Factor, leukemia, Tumor necrosis | Stem Cell Exhaustion | Compared with the control group, leukemia inhibitory factor, stem cell factor (SCF), stromal cell-derived factor (SDF-1), bone morphogenetic protein 4, hematopoietic stem cell (HSC) stimulating factor, and transforming growth factor-b in the MDS group were significantly downregulated (P<0.05), while interferon-g (IFN-g), tumor necrosis factor-a (TNF-a), and programmed death ligand (B7-H1) were significantly upregulated (P<0.05). | 25608238 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Chromosome Aberrations | Stem Cell Exhaustion | The purpose of this study was to explore cytokine expression patterns and cytogenetic abnormalities of mesenchymal stem cells (MSCs) from the bone marrow microenvironment of Chinese patients with myelodysplastic syndromes (MDS). | 25608238 |
| Ischemia | Stem Cell Exhaustion | Bone-marrow-derived very small embryonic-like stem cells in patients with critical leg ischaemia: evidence of vasculogenic potential. | 25608764 |
| Tissue injury | Stem Cell Exhaustion | Very small embryonic-like stem cells (VSELs) are multipotent stem cells localised in adult bone marrow (BM) that may be mobilised into peripheral blood (PB) in response to tissue injury. | 25608764 |
| Bisphosphonate-Associated Osteonecrosis of the Jaw | Stem Cell Exhaustion | Evaluation of the therapeutic effects of conditioned media from mesenchymal stem cells in a rat bisphosphonate-related osteonecrosis of the jaw-like model. | 25613174 |
| melanoma | Stem Cell Exhaustion | The purpose of this study was to investigate the expression profile of EZH2 and H3K4me2 and H3K27me3, which constitute stem cell-like "bivalent" domains, in cutaneous malignant melanoma. | 25614949 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Our results suggest the possibility that combined immunohistochemical expression of EZH2, H3K4me2, and H3K27me3 might identify cancer cells with potential stem cell properties, particularly at the IF of this malignancy. | 25614949 |
| Specialty Type - cancer, Carcinogenesis | Stem Cell Exhaustion | Cancer stem cells and the misregulation of epigenetic modifications have been identified to possess a determinative role in carcinogenesis. | 25614949 |
| Multiple Myeloma | Stem Cell Exhaustion | So far long-lived plasma cells can only be depleted by immunoablative therapy with antithymocyte globulin in the setting of stem cell transplantation or by treatment with proteasome inhibitors approved for multiple myeloma. | 25616773 |
| Graft-vs-Host Disease, Steroid-Refractory Pneumonitis | Stem Cell Exhaustion | We performed a retrospective study to identify pretransplantation risk factors for steroid-refractory (SR) acute graft-versus host disease (aGVHD) after allogeneic stem cell transplantation from matched donors in 630 adult patients who underwent transplantation at our center between 2000 and 2012. | 25617807 |
| Experimental Autoimmune Encephalomyelitis | Stem Cell Exhaustion | Administration of embryonic stem cell-derived thymic epithelial progenitors expressing MOG induces antigen-specific tolerance and ameliorates experimental autoimmune encephalomyelitis. | 25618825 |
| Liver Dysfunction, Hepatitis B | Stem Cell Exhaustion | We present a case of severe hepatic dysfunction due to Hepatitis B and sirolimus toxicity, in a 51-year-old male stem cell transplant recipient. | 25619898 |
| Cerebrovascular accident, Acute myocardial infarction | Stem Cell Exhaustion | Mobilization of endothelial progenitor cells in acute cardiovascular events in the PROCELL study: time-course after acute myocardial infarction and stroke. | 25619946 |
| Electrocardiogram: myocardial infarction (finding), Inflammation, Corneal Endothelial Cell Loss, Venous Stroke | Stem Cell Exhaustion | The aim of our study was to characterize and compare the short- and long-term mobilization of endothelial progenitor cells and circulating endothelial cells after acute myocardial infarction or atherothrombotic stroke, and to determine the relationship between these cell counts and plasma concentrations of vascular cell adhesion molecule (VCAM-1) and Von Willebrand factor (VWF) as surrogate markers of endothelial damage and inflammation. | 25619946 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Myocardial infarction patients had higher counts of endothelial progenitor cells and circulating endothelial cells than the controls (201.0/mL vs. 57.0/mL; p<0.01 and 181.0/mL vs. 62.0/mL; p<0.01). | 25619946 |
| Cerebrovascular accident | Stem Cell Exhaustion | In stroke patients, the number of endothelial progenitor cells - but not circulating endothelial cells - was higher than in controls (90.0/mL vs. 37.0/mL; p=0.01; 105.0/mL vs. 71.0/mL; p=0.11). | 25619946 |
| Cerebrovascular accident | Stem Cell Exhaustion | At 30 days after stroke, however, VCAM-1 peaked (628.1/mL vs. 869.1/mL; p<0.01) but there was no significant change in endothelial progenitor cells (90/mL vs. 78/mL; p<0.34). | 25619946 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Cultured endothelial progenitor cells from controls and myocardial infarction patients had endothelial phenotype characteristics and exhibited functional differences in adhesion and Ca(2+) influx, but not in proliferation and vasculogenesis. | 25619946 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | In myocardial infarction patients, VCAM-1 levels and mobilization of endothelial progenitor cells peaked at 30 days after the ischemic event. | 25619946 |
| Cerebrovascular accident | Stem Cell Exhaustion | Although a similar VCAM-1 kinetic was observed in stroke patients, endothelial progenitor cells did not increase. | 25619946 |
| Neoplasms | Stem Cell Exhaustion | The approach consisted in comparing phenotype profile of CTCs, and their progenitor Tumour Stem Cells, (TSCs). | 25620181 |
| Fungal Colonization, Mycoses | Stem Cell Exhaustion | Amphotericin B deoxycholate nasal spray administered to hematopoietic stem cell recipients with prior fungal colonization of the upper airway passages is associated with low rates of invasive fungal infection. | 25620386 |
| Mycoses | Stem Cell Exhaustion | Invasive fungal infections cause major problems during hematopoietic stem cell transplantation (HSCT). | 25620386 |
| Cessation of life, Myeloid neoplasm | Stem Cell Exhaustion | Moreover, cytotoxic treatments destroy normal stem cells with intact p53 systems, a problem especially for myeloid neoplasms, as these cells reverse the low blood counts that cause morbidity and death. | 25621498 |
| Peripheral Blood Stem Cells | Stem Cell Exhaustion | The median age was 51 years (range, 18 to 74) with 52% undergoing reduced-intensity conditioning and 48% undergoing myeloablative conditioning HSCT with T cell-replete peripheral blood stem cells (93.7%) or marrow (6.4%) grafts. | 25623931 |
| Hemopoietic stem cell transplant | Stem Cell Exhaustion | More NC were detected in the age group of children aged under 6 years with high-degree ALL, at higher levels of severity and in patients who had received a haematopoietic stem-cell transplant, all of them with statistically significant differences. | 25624086 |
| neurological complication, Hemopoietic stem cell transplant, Acute leukemia | Stem Cell Exhaustion | Neurological complications are common in patients with acute leukaemia, especially in those at a high-risk stage (above all if they are under the age of 6 years) and with haematopoietic stem-cell transplant. | 25624086 |
| Colorectal Carcinoma, Malignant tumor of colon, Secondary malignant neoplasm of liver | Stem Cell Exhaustion | Colon cancer stem cell markers CD44 and CD133 in patients with colorectal cancer and synchronous hepatic metastases. | 25625240 |
| Colorectal Carcinoma, Specialty Type - cancer, Secondary malignant neoplasm of liver | Stem Cell Exhaustion | CD44 and CD133 mRNA expression as cancer stem cell markers in colorectal cancer were correlated with synchronous hepatic metastases and the clinicopathological factors, including patient survival. | 25625240 |
| Comorbidity, Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | At present, a standard therapy for de novo multiple myeloma (MM) patients under 65 years old without severe comorbidity is an upfront high dose chemotherapy (HDCT) with MEL200 combined with auto peripheral blood stem cell transplantation (autoPBSCT) after the induction therapy. | 25626309 |
| Adult Glioblastoma | Stem Cell Exhaustion | Among miRNAs screened, we found that miR340 expression was decreased in all human GICs and in human glioblastoma tissues, compared with human neural stem cells and normal brain tissues. | 25627976 |
| Structure of auricular appendage | Stem Cell Exhaustion | Clinical-scale in vitro expansion preserves biological characteristics of cardiac atrial appendage stem cells. | 25630660 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Cardiac atrial appendage stem cells (CASCs) have recently emerged as an attractive candidate for cardiac regeneration after myocardial infarction. | 25630660 |
| Specialty Type - cancer | Stem Cell Exhaustion | Upregulation of circulating cancer stem cell marker, DCLK1 but not Lgr5, in chemoradiotherapy-treated colorectal cancer patients. | 25631749 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cell (CSC) markers have attracted considerable attention in tumor diagnostic, prognostic, and therapeutic implications. | 25631749 |
| Specialty Type - cancer | Stem Cell Exhaustion | Detection of cancer stem cells in circulating blood using cancer stem cell markers has received remarkable attention recently. | 25631749 |
| BARRIER, Infection of bloodstream | Stem Cell Exhaustion | The burden of mucosal barrier injury laboratory-confirmed bloodstream infection among hematology, oncology, and stem cell transplant patients. | 25632993 |
| BARRIER, Infection of bloodstream | Stem Cell Exhaustion | To evaluate the impact and burden of the new National Healthcare Safety Network surveillance definition, mucosal barrier injury laboratory-confirmed bloodstream infection (MBI-LCBI), in hematology, oncology, and stem cell transplant populations. | 25632993 |
| Infection | Stem Cell Exhaustion | Most CLABSIs identified among hematology, oncology, and stem cell transplant patients met MBI-LCBI criteria, and CLABSI prevention efforts did not reduce these infections. | 25632993 |
| Primary Myelofibrosis | Stem Cell Exhaustion | Diagnostic value of 18F-FDG-PET/CT for monitoring myelofibrosis after allogeneic stem cell transplantation. | 25633515 |
| bone marrow fibrosis, Primary Myelofibrosis | Stem Cell Exhaustion | Myelofibrosis is a rare hematopoietic stem cell neoplasm leading to marked bone marrow fibrosis and ineffective hematopoiesis. | 25633515 |
| Primary Myelofibrosis | Stem Cell Exhaustion | A 62-year-old man with myelofibrosis underwent FDG-PET/CT for evaluation of the extent of disease before and after allogeneic stem cell transplantation (SCT). | 25633515 |
| Acute leukemia | Stem Cell Exhaustion | T-cell-replete haploidentical transplantation versus autologous stem cell transplantation in adult acute leukemia: a matched pair analysis. | 25637051 |
| Acute leukemia | Stem Cell Exhaustion | Adult patients with acute leukemia in need of a transplant but without a genoidentical donor are usually considered upfront for transplantation with stem cells from any other allogeneic source, rather than autologous stem cell transplantation. | 25637051 |
| Hyperammonemia | Stem Cell Exhaustion | Fatal hyperammonemia and carbamoyl phosphate synthetase 1 (CPS1) deficiency following high-dose chemotherapy and autologous hematopoietic stem cell transplantation. | 25639153 |
| Hyperammonemia, Central neuroblastoma | Stem Cell Exhaustion | We observed severe hyperammonemia (maximum 475 mmol/L) in a 2-year-old male patient, who underwent high-dose chemotherapy with carboplatin, etoposide and melphalan, and autologous hematopoietic stem cell transplantation for a neuroblastoma stage IV. | 25639153 |
| Failure, Hyperammonemia | Stem Cell Exhaustion | Moreover, we highlight the need for urgent diagnostic and therapeutic strategies addressing a possible secondary urea cycle failure in future patients with hyperammonemia during chemotherapy and stem cell transplantation. | 25639153 |
| Hallopeau-Siemens Disease | Stem Cell Exhaustion | This study has warranted future clinical investigation of USSCs as a novel and universal allogeneic stem cell donor source in selected patients with RDEB. | 25640200 |
| Mucocutaneous candidiasis, Hallopeau-Siemens Disease | Stem Cell Exhaustion | Rescue of the mucocutaneous manifestations by human cord blood derived nonhematopoietic stem cells in a mouse model of recessive dystrophic epidermolysis bullosa. | 25640200 |
| Childhood Non-Hodgkin Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Stem cell yield in patients with non-Hodgkin lymphoma was lower compared to patients with multiple myeloma. | 25641128 |
| Squamous cell carcinoma of the head and neck | Stem Cell Exhaustion | Detection of putative stem cell markers, CD44/CD133, in primary and lymph node metastases in head and neck squamous cell carcinomas. | 25641707 |
| Specialty Type - cancer, Squamous cell carcinoma of the head and neck, Secondary malignant neoplasm of lymph node | Stem Cell Exhaustion | Investigators hypothesized that cancer stem cells (CSCs) could play a role in determining cancer progression by metastasizing to cervical lymph node (N+) and then influencing prognosis of head and neck squamous cell carcinomas (HNSCCs) patients. | 25641707 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Survival and graft-versus-host disease in patients receiving peripheral stem cell compared to bone marrow transplantation from HLA-matched related donor: retrospective analysis of 334 consecutive patients. | 25645430 |
| Neoplasms | Stem Cell Exhaustion | Patients with this methylation profile harbor messenger RNA-based signatures indicating tumors with progenitor cell features. | 25645722 |
| Neoplasms, Squamous cell carcinoma of the head and neck | Stem Cell Exhaustion | Mesenchymal stem cells are enriched in head neck squamous cell carcinoma, correlates with tumour size and inhibit T-cell proliferation. | 25647013 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer is a multifactorial disease not only restricted to transformed epithelium, but also involving cells of the immune system and cells of mesenchymal origin, particularly mesenchymal stem cells (MSCs). | 25647013 |
| Skeletal muscle structure | Stem Cell Exhaustion | The regeneration of muscle tissue has been achieved using multipotent mesenchymal stem cells in mouse models of injured skeletal muscle. | 25647308 |
| Becker Muscular Dystrophy | Stem Cell Exhaustion | In the present study, the utility of multipotent human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) in the treatment of Becker muscular dystrophy (BMD), a genetic disease where muscle tissue fails to regenerate, was examined in members from a pedigree affected by BMD. | 25647308 |
| Primary granulocytic sarcoma | Stem Cell Exhaustion | Allogeneic Hematopoietic Stem Cell Transplantation as Treatment for Primary Granulocytic Sarcoma of the Breast. | 25647745 |
| Mycoses, Communicable Diseases | Stem Cell Exhaustion | Polymicrobial bacterial or fungal infections: incidence, spectrum of infection, risk factors, and clinical outcomes from a large hematopoietic stem cell transplant center. | 25648349 |
| Infection | Stem Cell Exhaustion | Infections cause significant morbidity and mortality for patients who undergo hematopoietic stem cell transplantation (HSCT). | 25648349 |
| Haiti, Amyloidosis | Stem Cell Exhaustion | Eight of nine patients with AL amyloidosis began chemotherapy prior to HT, six have resumed chemotherapy since HT, and five have undergone autologous stem cell transplantation. | 25648766 |
| Lupus Erythematosus, Encephalitis, St. Louis | Stem Cell Exhaustion | Recent studies showed that allogeneic bone marrow (BM)-mesenchymal stem cells transplantation (MSCT) was effective in systemic lupus erythematosus (SLE) patients and lupus-prone mice. | 25649549 |
| Hematological Disease | Stem Cell Exhaustion | A total of 150 adult patients with high-risk hematologic diseases who underwent allogeneic hematopoietic stem cell transplantation from alternative donors at 2 centers (Paoli-Calmettes Institute [Marseille, France] and Humanitas Cancer Center [Milan, Italy]) were analyzed. | 25649994 |
| Thrombotic Microangiopathies | Stem Cell Exhaustion | Use of Eculizumab in Patients With Allogeneic Stem Cell Transplant-Associated Thrombotic Microangiopathy: A Study From the SFGM-TC. | 25651309 |
| Thrombomodulin Alfa, Thrombotic Microangiopathies | Stem Cell Exhaustion | Thrombotic microangiopathy (TMA) occurring after allogeneic hematopoietic stem cell transplantation (HSCT) has a devastating prognosis. | 25651309 |
| Hyperglycemia, Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Umbilical cord mesenchymal stem cell transfusion ameliorated hyperglycemia in patients with type 2 diabetes mellitus. | 25651730 |
| Chronic graft-versus-host disease | Stem Cell Exhaustion | Recent studies have considered the qualitative and quantitative assessment of salivary flow, as well the biochemical components of saliva, as possible biomarkers that might contribute to the pathogenesis of chronic graft-versus-host disease (cGHVD) in hematopoietic stem cell transplantation (HSCT) patients. | 25652148 |
| Glioblastoma Multiforme Pathway, Neoplasms | Stem Cell Exhaustion | This glioma study brings together actions of a normal epigenetic mechanism (JMJD3 activity) with dysfunctional activation of senescence-related processes, including secretion of SASP proinflammatory cytokines and stem cell tropism toward tumors. | 25652587 |
| Neoplasms | Stem Cell Exhaustion | These studies are therapeutically relevant because inflammatory cytokines have been linked to homing of neural stem cells and other stem cells to tumor loci. | 25652587 |
| T-Cell Lymphoma | Stem Cell Exhaustion | Comparison of survival in patients with T cell lymphoma after autologous and allogeneic stem cell transplantation as a frontline strategy or in relapsed disease. | 25652691 |
| RHOJ gene, T-Cell Lymphoma | Stem Cell Exhaustion | We studied the roles of autologous (A) and allogeneic (allo) stem cell transplantation (SCT) in the treatment of 134 patients with T cell lymphoma (TCL) at our center. | 25652691 |
| Old age | Stem Cell Exhaustion | The antisenescence effect of trans-cinnamaldehyde on adipose-derived stem cells. | 25654692 |
| cinnamic aldehyde, Transcobalamin | Stem Cell Exhaustion | The aim of this study was to demonstrate the capacity of Trans-cinnamaldehyde (TC) in reversing stress-induced senescence and maintaining the quality of stem cells in a chemically (H2O2)-induced cell senescence model. | 25654692 |
| Infarction, Middle Cerebral Artery | Stem Cell Exhaustion | We sought to determine MR imaging findings after mesenchymal stem cell implantation in chronic middle cerebral artery infarcts and to compare brain volume changes in patients with mesenchymal stem cells with those in age-matched healthy controls and controls with chronic stable MCA infarcts. | 25655873 |
| Volume | Stem Cell Exhaustion | Volumetric analysis showed a trend toward less overall volume loss after mesenchymal stem cell implantation (0.736; 95% CI, -4.15-5.62) compared with that in age- and sex-matched controls with chronic, stable MCA infarcts (-3.59; 95% CI, -12.3 to -5.21; P = .09), with a significantly greater growth-to-loss ratio in infarcted regions (1.30 and 0.78, respectively, P = .02). | 25655873 |
| Volume | Stem Cell Exhaustion | Initial findings suggest a trend toward less volume loss after mesenchymal stem cell implantation compared with that in age- and sex-matched controls with chronic, stable MCA infarcts, with a significantly greater growth-to-loss ratio in the infarcted tissue. | 25655873 |
| Infarction, Anterior Cerebral Artery | Stem Cell Exhaustion | Qualitative and quantitative analysis of MR imaging findings in patients with middle cerebral artery stroke implanted with mesenchymal stem cells. | 25655873 |
| Ischemic stroke | Stem Cell Exhaustion | Mesenchymal stem cells have potential as a regenerative therapy in ischemic stroke. | 25655873 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Outcome of Patients With Non-Hodgkin Lymphomas With Concurrent MYC and BCL2 Rearrangements Treated With CODOX-M/IVAC With Rituximab Followed by Hematopoietic Stem Cell Transplantation. | 25656914 |
| Epidermolysis Bullosa | Stem Cell Exhaustion | Immunogenicity of decidual stromal cells in an epidermolysis bullosa patient and in allogeneic hematopoietic stem cell transplantation patients. | 25658253 |
| Graft-vs-Host Disease, Hemorrhagic cystitis | Stem Cell Exhaustion | Two of 16 allogeneic stem cell-transplanted patients, treated with DSCs for graft-versus-host disease or hemorrhagic cystitis, showed a positive flow cytometric crossmatch test. | 25658253 |
| Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | The circulating endothelial progenitor cell level (percent of CD45(-)CD34(+) VEGF-R2(+) cells in total peripheral blood mononuclear cells) was quantified in 47 patients with renal cell carcinoma and 40 healthy controls. | 25659661 |
| Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | The circulating endothelial progenitor cell level was significantly higher in patients with renal cell carcinoma than in healthy controls (0.276% vs 0.086%, p <0.001). | 25659661 |
| Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | Earlier emergence of circulating endothelial progenitor cell colonies, a higher cell culture success rate and more colonies were found for patients with renal cell carcinoma than for healthy controls. | 25659661 |
| Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | Culture and Characterization of Circulating Endothelial Progenitor Cells in Patients with Renal Cell Carcinoma. | 25659661 |
| Neoplasms, Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | Although emerging evidence demonstrates increased circulating endothelial progenitor cells in patients with solid tumors, to our knowledge it is still unknown whether such cells can be cultured from patients with highly angiogenic renal cell carcinoma. | 25659661 |
| Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | We cultured and characterized circulating endothelial progenitor cells from patients with renal cell carcinoma. | 25659661 |
| Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | Peripheral blood mononuclear cells were then isolated from 33 patients with renal cell carcinoma and 30 healthy controls to culture and characterize circulating endothelial progenitor cells. | 25659661 |
| Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | However, significantly more VEGF-R2(+) circulating endothelial progenitor cells were found in preparations from patients with renal cell carcinoma than from healthy controls (21.1% vs 13.4%, p <0.001). | 25659661 |
| Have Been Vomiting | Stem Cell Exhaustion | Addition of Aprepitant (Emend(r)) to Standard Antiemetic Regimen Continued for 7 Days after Chemotherapy for Stem Cell Transplantation Provides Significant Reduction of Vomiting. | 25659986 |
| Refractory Chemotherapy-Induced Nausea and Vomiting, Chemotherapy-induced Nausea and Vomiting Questionnaire | Stem Cell Exhaustion | Chemotherapy-induced nausea/vomiting (CINV) is a major problem for patients treated with high-dose chemotherapy (HDCT) conditioning before stem cell transplantation (SCT), both during chemotherapy and afterwards (delayed nausea/vomiting). | 25659986 |
| Vancomycin-Resistant Enterococci, Fever | Stem Cell Exhaustion | Empiric use of linezolid in febrile hematology and hematopoietic stem cell transplantation patients colonized with vancomycin-resistant Enterococcus spp. | 25660090 |
| Amyloidosis | Stem Cell Exhaustion | Extended follow up of high-dose melphalan and autologous stem cell transplantation after vincristine, doxorubicin, dexamethasone induction in amyloid light chain amyloidosis of the prospective phase II HOVON-41 study by the Dutch-Belgian Co-operative Trial Group for Hematology Oncology. | 25661441 |
| Amyloidosis | Stem Cell Exhaustion | However, a 2-step approach consisting of a non-intensive less toxic induction therapy followed by high-dose melphalan and autologous stem cell transplantation may result in extended survival in newly diagnosed patients with amyloid light chain amyloidosis (clinicaltrials.gov identifier: 01207094). | 25661441 |
| Squamous cell carcinoma | Stem Cell Exhaustion | Voriconazole exposure and the risk of cutaneous squamous cell carcinoma in allogeneic hematopoietic stem cell transplant patients. | 25661996 |
| Physical activity decreased | Stem Cell Exhaustion | We conducted the first-regenerative medicine cellular therapy for underactive bladder (UAB) in an FDA-approved, compassionate-use IND trial to evaluate treatment safety and potential clinical efficacy of autologous muscle-derived stem cells (AMDC) on a patient with UAB. | 25663053 |
| Nontuberculous Mycobacteria | Stem Cell Exhaustion | The clinical importance of the isolation of nontuberculous mycobacteria (NTM) from respiratory specimens of stem cell transplant (SCT) recipients is not clear. | 25663510 |
| Multiple Myeloma | Stem Cell Exhaustion | Immunomodulatory effects of the Agaricus blazei Murrill-based mushroom extract AndoSan in patients with multiple myeloma undergoing high dose chemotherapy and autologous stem cell transplantation: a randomized, double blinded clinical study. | 25664323 |
| Multiple Myeloma | Stem Cell Exhaustion | Forty patients with multiple myeloma scheduled to undergo high dose chemotherapy with autologous stem cell support were randomized in a double blinded fashion to receive adjuvant treatment with the mushroom extract AndoSan, containing 82% of Agaricus blazei Murrill (19 patients) or placebo (21 patients). | 25664323 |
| Agenesis | Stem Cell Exhaustion | Intake of the study product started on the day of stem cell mobilizing chemotherapy and continued until the end of aplasia after high dose chemotherapy, a period of about seven weeks. | 25664323 |
| Crohn Disease, Spondylarthritis | Stem Cell Exhaustion | Lymphatic endothelial progenitor cells and vascular endothelial growth factor-C in spondyloarthritis and Crohn's disease: two overlapping diseases? | 25664492 |
| Glioblastoma Multiforme Pathway, Adult Glioblastoma | Stem Cell Exhaustion | Effect of Notch expression in glioma stem cells on therapeutic response to chemo-radiotherapy in recurrent glioblastoma. | 25665548 |
| Glioblastoma Multiforme Pathway, Neoplasms | Stem Cell Exhaustion | Glioma stem cells (GSCs) have the capacity to repopulate tumors and mediate resistance to radiotherapy and chemotherapy. | 25665548 |
| CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology | Stem Cell Exhaustion | Antithymocyte globulin (ATG) is the drug of choice for immunosuppressive therapy (IST) in patients with SAA ineligible for allogeneic stem cell transplantation. | 25666078 |
| Malignant neoplasm of lung | Stem Cell Exhaustion | KRAS mutations (codons 12/13) were found to be a biomarker of radiosensitization by midostaurin in lung cancer, which was pronounced under conditions that enriched for stem cell-like cells. | 25667133 |
| Cessation of life, HIV-1 | Stem Cell Exhaustion | g-Herpesvirus load as surrogate marker of early death in HIV-1 lymphoma patients submitted to high dose chemotherapy and autologous peripheral blood stem cell transplantation. | 25668032 |
| HIV | Stem Cell Exhaustion | Autologous stem cell transplantation (ASCT) is a feasible procedure for human immunodeficiency virus-1 (HIV-1) lymphoma patients, whose underlying disease and intrinsic HIV-1- and ASCT-associated immunodeficiency might increase the risk for g-herpesvirus load persistence and/or reactivation. | 25668032 |
| Hepatitis B | Stem Cell Exhaustion | However, three anti-HBc/anti-HBs positive patients who were treated with allogeneic hematopoietic stem cell transplantation demonstrated hepatitis B virus reactivation within 12 months from transplant. | 25671825 |
| Hepatitis B, Communicable Diseases | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation is a high risk condition for late hepatitis B virus reactivation in patients with resolved infection. | 25671825 |
| Osteopetrosis | Stem Cell Exhaustion | Various treatment options have been suggested for osteopetrosis, but hematopoietic stem cell transplantation still remains the only curative treatment option presently. | 25673572 |
| melanoma | Stem Cell Exhaustion | Increased expression of melanoma stem cell marker CD271 in metastatic melanoma to the brain. | 25674270 |
| melanoma | Stem Cell Exhaustion | Human melanoma contains multipotent stem cells that express the neural crest stem cell marker CD271. | 25674270 |
| Primary Myelofibrosis, Myeloproliferation, Hyperplasia | Stem Cell Exhaustion | Myelofibrosis is a rare clonal hematopoietic stem cell disorder characterized by chronic myeloproliferation, atypical megakaryocytic hyperplasia, and potential leukemic transformation. | 25674874 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | HLA-matched allogeneic stem cell transplantation improves outcome of higher risk myelodysplastic syndrome A prospective study on behalf of SFGM-TC and GFM. | 25676424 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (HSCT) is considered the only a curative treatment in patients with higher risk myelodysplastic syndrome (MDS), although demethylating agents (DMA) have been reported to improve survival. | 25676424 |
| Pudendal Neuralgia | Stem Cell Exhaustion | The aim of this prospective study was to investigate the feasibility and report the short-term results of a new procedure for treatment of pudendal neuralgia, consisting of transperineal injections of autologous adipose tissue with stem cells along the Alcock's canal. | 25677417 |
| Specialty Type - cancer, Metaplastic carcinoma of breast | Stem Cell Exhaustion | Cancer stem cell and epithelial-mesenchymal transition markers predict worse outcome in metaplastic carcinoma of the breast. | 25677743 |
| Specialty Type - cancer | Stem Cell Exhaustion | Antibodies to ER, PR, HER2, CK14, EGFR, 34bE12, cancer stem cell markers (CD44, CD24, ALDH1A1), epithelial-mesenchymal transition markers (Twist and E-cadherin), were applied. | 25677743 |
| Malignant neoplasm of breast, Specialty Type - cancer | Stem Cell Exhaustion | Expression of cancer stem cell and epithelial-mesenchymal transition markers in metaplastic breast cancers correlates with adverse pathological parameters and outcome. | 25677743 |
| Metaplastic carcinoma of breast, Specialty Type - cancer | Stem Cell Exhaustion | Metaplastic breast carcinomas are known to overexpress markers of epithelial-mesenchymal transition and cancer stem cells. | 25677743 |
| Malignant neoplasm of stomach, Specialty Type - cancer | Stem Cell Exhaustion | 5-Fluorouracil chemotherapy of gastric cancer generates residual cells with properties of cancer stem cells. | 25678847 |
| Specialty Type - cancer | Stem Cell Exhaustion | Emerging evidence suggests that the existence of cancer stem cells (CSCs) contributes to chemoresistance. | 25678847 |
| Alzheimers Disease | Stem Cell Exhaustion | Prostate stem cell antigen interacts with nicotinic acetylcholine receptors and is affected in Alzheimer's disease. | 25680266 |
| Thrombocytopenia due to platelet alloimmunization, Hematopoietic stem cells | Stem Cell Exhaustion | We examined the effects of serum and IgG from 19 patients with immune thrombocytopenia using day 8 or 9 megakaryocytes (66.3 +- 10.6% CD41(+)), derived from cord blood hematopoietic stem cells (CD34(+)). | 25682608 |
| Neoplasms | Stem Cell Exhaustion | Cells cultured from the tumor show stem cell properties that could contribute to the recurrent tumor growth. | 25682776 |
| Hodgkin Disease | Stem Cell Exhaustion | Pre-transplantation (18)F-fluorodeoxyglucose (FDG) PET-negativity is one of the strongest predictors of outcome after high-dose therapy and autologous stem-cell transplant (HDT/ASCT) for patients with relapsed or refractory Hodgkin's lymphoma. | 25683846 |
| CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology | Stem Cell Exhaustion | Overall survival (OS) after upfront human leucocyte antigen-matched family donor (MFD) haematopoietic stem cell transplantation (HSCT) or immunosuppressive treatment (IST) was 91% vs. 87% (P 0*18). | 25683884 |
| Neoplasms | Stem Cell Exhaustion | The 'transdifferentiation' of NET cells into ductular cells is considered as the most plausible histogenetic mechanism of this tumor, although other possibilities, such as an origin from a primitive endodermal stem cell or the induction of ductular proliferation by stimulation with NET-derived humoral factors, cannot be excluded. | 25684418 |
| Hematologic Neoplasms, Myeloproliferative disease, DPM1 gene | Stem Cell Exhaustion | Myeloproliferative disorders (MPDs) are clonal hematologic malignancies originating at the level of the pluripotent hematopoietic stem cell. | 25684469 |
| Infection, Aspergillosis | Stem Cell Exhaustion | After hematopoietic stem cell transplantation, invasive aspergillosis remains one of the most lethal infections. | 25688598 |
| Multiple Myeloma | Stem Cell Exhaustion | Content of endothelial progenitor cells in autologous stem cell grafts predict survival after transplantation for multiple myeloma. | 25689789 |
| Malignant Neoplasms | Stem Cell Exhaustion | Multiple myeloma (MM) is considered an incurable B cell malignancy, although many patients can benefit from high-dose therapy with autologous stem cell transplantation (ASCT) as a first-line treatment. | 25689789 |
| Lymphoma, Non-Hodgkin, Familial | Stem Cell Exhaustion | Here, we investigated the clinical impact of EPC levels in peripheral blood stem cell (PBSC) autografts for MM and NHL patients who received ASCT. | 25689789 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Zevalin and BEAM (Z-BEAM) versus rituximab and BEAM (R-BEAM) conditioning chemotherapy prior to autologous stem cell transplantation in patients with mantle cell lymphoma. | 25689832 |
| Degenerative disorder of cartilage | Stem Cell Exhaustion | Chondrocyte clusters adjacent to sites of cartilage degeneration have characteristics of progenitor cells. | 25691232 |
| Febrile Neutropenia | Stem Cell Exhaustion | The routine use of chest radiographs (CXRs) in the initial evaluation of asymptomatic patients with febrile neutropenia undergoing hematopoietic stem cell transplant (HSCT) is controversial. | 25691611 |
| Prostate carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Expression of stem cell marker CD44 in prostate cancer biopsies predicts cancer grade in radical prostatectomy specimens. | 25693083 |
| Prostate carcinoma | Stem Cell Exhaustion | We used a stem cell marker CD44 to evaluate the prevalence of prostate cancer stem cells in prostate biopsies and in matched radical prostatectomy specimens. | 25693083 |
| Specialty Type - cancer, Adenocarcinoma of prostate | Stem Cell Exhaustion | Cancer stem cells play an important role in development and progression of many cancer types including prostate adenocarcinoma. | 25693083 |
| Nerve Degeneration | Stem Cell Exhaustion | Brief report: isogenic induced pluripotent stem cell lines from an adult with mosaic down syndrome model accelerated neuronal ageing and neurodegeneration. | 25694335 |
| Prostate carcinoma, Benign prostatic hypertrophy | Stem Cell Exhaustion | Prostate stem cell antigen (PSCA) mRNA expression in peripheral blood in patients with benign prostatic hyperplasia and/or prostate cancer. | 25698533 |
| Prostate carcinoma, Passive Cutaneous Anaphylaxis | Stem Cell Exhaustion | The aim of this study was to determine whether detection of prostate stem cell antigen (PSCA) expression in BPH might be associated with the subsequent presence of Prostate cancer (PCa) and also to determine whether detection of PSCA expression has potential for prognosis in PCa. | 25698533 |
| Histogenic Process, Carcinoma | Stem Cell Exhaustion | For clarifying the histogenesis, immunophenotypic analysis of the 3 different components of the carcinoma was performed using hair follicle stem cell markers (eg, CK15, CK19, and CD200) that have been identified as biomarkers of human bulge cells. | 25699980 |
| Histogenic Process, Merkel cell carcinoma, Sweat gland adenocarcinoma, Hair follicle structure, Carcinoma, Spindle-Cell | Stem Cell Exhaustion | Merkel cell carcinoma with glandular differentiation admixed with sweat gland carcinoma and spindle cell carcinoma: histogenesis of merkel cell carcinoma from hair follicle stem cells. | 25699980 |
| Hair follicle structure | Stem Cell Exhaustion | We posit that the MCC arose from hair follicle stem cells residing within the bulge area where Merkel cells are preferentially situated. | 25699980 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Accelerated onset of senescence of endothelial progenitor cells in patients with type 2 diabetes mellitus: role of dimethylarginine dimethylaminohydrolase 2 and asymmetric dimethylarginine. | 25701782 |
| Juvenile Myelomonocytic Leukemia | Stem Cell Exhaustion | Juvenile myelomonocytic leukemia (JMML) is not durably responsive to chemotherapy, and approximately 50% of patients relapse after hematopoietic stem cell transplant (HSCT). | 25704135 |
| B-Cell Lymphomas | Stem Cell Exhaustion | A phase 2 study of inotuzumab ozogamicin and rituximab, followed by autologous stem cell transplant in patients with relapsed/refractory diffuse large B-cell lymphoma. | 25707288 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | This study evaluated the safety and efficacy of inotuzumab ozogamicin (INO), a targeted humanized anti-CD22 antibody conjugated to calicheamicin, plus rituximab (R-INO) every 3 weeks, up to six cycles, followed by high dose therapy and autologous stem cell transplant (HDT-aSCT) in patients with high-risk relapsed/refractory diffuse large B-cell lymphoma (DLBCL). | 25707288 |
| Multiple Myeloma | Stem Cell Exhaustion | Cord blood has been investigated as an alternative source for hematopoietic stem cell transplantation, but information about its use for multiple myeloma is limited. | 25708214 |
| neurological complication | Stem Cell Exhaustion | Neurologic complications after allogeneic hematopoietic stem cell transplantation in children: analysis of prognostic factors. | 25708217 |
| neurological complication | Stem Cell Exhaustion | Neurologic complications are serious complications after hematopoietic stem cell transplantation (HSCT) and significantly contribute to morbidity and mortality. | 25708217 |
| Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Chronic graft-versus-host disease (cGVHD) is a critical complication after allogeneic hematopoietic stem cell transplantation. | 25708216 |
| Chronic graft-versus-host disease | Stem Cell Exhaustion | Phenotypical and functional characterization of bone marrow mesenchymal stem cells in patients with chronic graft-versus-host disease. | 25708216 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Effect of graft source on unrelated donor hemopoietic stem cell transplantation in adults with acute myeloid leukemia after reduced-intensity or nonmyeloablative conditioning: a study from the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire. | 25708220 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | This retrospective report compared the 4-year outcomes of allogeneic stem cell transplantation (allo-SCT) in 651 adult patients with acute myeloid leukemia receiving a reduced-intensity (RIC) or nonmyeloablative conditioning (NMA) regimen according to the type of unrelated donors. | 25708220 |
| Hematologic Neoplasms, Virus Diseases | Stem Cell Exhaustion | Cord blood transplantation (CBT) is curative for many patients with hematologic malignancies but is associated with delayed immune recovery and an increased risk of viral infections compared with HLA-matched bone marrow or peripheral blood progenitor cell transplantation. | 25708219 |
| Specialty Type - cancer, Carcinoma | Stem Cell Exhaustion | Cancer Stem Cell Markers in Eyelid Sebaceous Gland Carcinoma: High Expression of ALDH1, CD133, and ABCG2 Correlates With Poor Prognosis. | 25711631 |
| Eyelid Sebaceous Gland Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | To investigate the expression of cancer stem cell (CSC) marker proteins in eyelid sebaceous gland carcinoma and evaluate the clinical significance. | 25711631 |
| MS gene | Stem Cell Exhaustion | High-dose immunosuppressive therapy (HDIT) with autologous hematopoietic stem cell transplantation (AHSCT) is a promising approach to treatment of multiple sclerosis (MS) patients. | 25711670 |
| Hematological Disease | Stem Cell Exhaustion | Haematopoietic stem cell transplantation (HSCT) cures many haematological cancers. | 25711722 |
| Medial collateral ligament, Toxic effect | Stem Cell Exhaustion | We identified 42 patients with MCL who discontinued therapy due to disease progression on treatment (n = 28), toxicity (n = 6), elective stem-cell transplant in remission (n = 4) or withdrawn consent (n = 4). | 25712454 |
| Malignant neoplasm of ovary, Specialty Type - cancer | Stem Cell Exhaustion | VAV3 Overexpressed in Cancer Stem Cells Is a Poor Prognostic Indicator in Ovarian Cancer Patients. | 25715123 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells (CSCs) are thought to contribute significantly to disease relapse and drug resistance. | 25715123 |
| TRPV6 wt Allele | Stem Cell Exhaustion | Various treatment regimens were applied in EATL during the past fifteen years including either monotherapy consisting of chemotherapy or resection, or combination therapy with both aforementioned regimens whether or not combined with stem-cell transplantation (SCT). | 25716069 |
| Gestational Diabetes | Stem Cell Exhaustion | This study provides strong evidence in neonatal endothelial progenitor cells that GDM exposure in utero leads to altered gene expression and DNA methylation, suggesting the possibility of altered epigenetic regulation. | 25720387 |
| Hair follicle structure | Stem Cell Exhaustion | We used hair follicle stem cell markers to investigate whether MCC share certain characteristics of these stem cells. | 25720654 |
| Hair follicle structure | Stem Cell Exhaustion | In six combined MCC, both MCC components and squamous components at least focally shared the expression of one or more of cytokeratin (CK)15, CK19 and CD200, which are hair follicle stem cell markers. | 25720654 |
| Hair follicle structure | Stem Cell Exhaustion | There was a distinct difference between pure MCC and combined MCC on the expression of hair follicle stem cell markers. | 25720654 |
| Infection caused by Helicobacter pylori, Duodenal Ulcer, Malignant neoplasm of stomach | Stem Cell Exhaustion | Two recent genome-wide association studies in Asians have reported the association between the PSCA (prostate stem cell antigen) rs2294008C>T gene polymorphism and two Helicobacter pylori infection-related diseases such as gastric cancer (GC) and duodenal ulcer (DU). | 25721731 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Somatic mutation of DNMT3A, especially at the Arg882 (R882) site of the DNMT3A coding sequence, has been identified in pre-leukemic stem cell clones as one of the driver mutations of acute myeloid leukemia (AML). | 25721756 |
| Hypoglycemia, diabetic | Stem Cell Exhaustion | Hypoglycemia affects the changes in endothelial progenitor cell levels during insulin therapy in type 2 diabetic patients. | 25722222 |
| Hypoglycemia | Stem Cell Exhaustion | Though PCs increased at study end, in patients experiencing at least 1 hypoglycemic episode, the changes in CD34(+), CD133(+) progenitor cells and CD34(+)KDR(+) EPCs were significantly lower than the respective changes in patients without incident hypoglycemia, even after correcting for confounders. | 25722222 |
| Specialty Type - cancer | Stem Cell Exhaustion | Subsets of long-lived, tumor-initiating stem cells often escape cancer therapies. | 25723170 |
| Squamous cell carcinoma | Stem Cell Exhaustion | Here, we devise a functional reporter system to lineage trace and/or genetic ablate signaling in TGF-b-activated squamous cell carcinoma stem cells (SCC-SCs). | 25723170 |
| Colorectal Carcinoma, Neoplasms, Pancreatic carcinoma | Stem Cell Exhaustion | Doublecortin-like kinase 1 (DCLK1) is a putative pancreatic stem cell marker and is upregulated in pancreatic cancer, colorectal cancer, and many other solid tumors. | 25723399 |
| Neoplasms, Intestinal Neoplasms | Stem Cell Exhaustion | It marks tumor stem cells in mouse models of intestinal neoplasia. | 25723399 |
| Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | Given the increasingly recognized role of EMT derived stem cells in cancer progression and metastasis, we hypothesize that DCLK1 may contribute to the metastatic process. | 25723399 |
| Primary Myelofibrosis | Stem Cell Exhaustion | CD133 marks a stem cell population that drives human primary myelofibrosis. | 25724578 |
| Primary Myelofibrosis | Stem Cell Exhaustion | Here we describe a CD133(+) stem cell population that drives the pathogenesis of primary myelofibrosis. | 25724578 |
| Primary Myelofibrosis | Stem Cell Exhaustion | This is the first characterization of a patient-derived stem cell population that drives disease resembling both chronic and acute phases of primary myelofibrosis in mice. | 25724578 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | There is increasing evidence that the existence of cancer stem cells (CSC) is responsible for tumour formation and maintenance. | 25727099 |
| Exfoliative dermatitis, Omenn Syndrome | Stem Cell Exhaustion | Since extensive erythroderma with generalized itching causes patient discomfort in Omenn syndrome, cyclosporin treatment can be considered while waiting for treatment with hematopoietic stem cell transplantation. | 25727345 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Enhanced engraftment and repairing ability of human adipose-derived stem cells, conveyed by pharmacologically active microcarriers continuously releasing HGF and IGF-1, in healing myocardial infarction in rats. | 25727843 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | To overcome this drawback, rats with 4-week-old myocardial infarction (MI) were injected in the border zone with human adipose-derived stem cells (ADSCs) conveyed by poly(lactic-co-glycolic acid) microcarriers (PAMs) releasing hepatocyte growth factor (HGF) and insulin-like growth factor-1 (IGF-1) (GFsPAMs). | 25727843 |
| Virus Diseases | Stem Cell Exhaustion | Most of the publications report data about stem cell transplant patients, little is known about these virus infections in renal transplant patients. | 25728075 |
| Special Handling Code - Dry | Stem Cell Exhaustion | In addition, clinical trials are currently underway outside Japan using human mesenchymal stromal cells and human neural stem cells to protect photoreceptors in RP and dry age-related macular degeneration, respectively. | 25728228 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Outcomes in multiple myeloma (MM) have improved significantly with novel agent therapy and autologous stem cell transplantation (ASCT). | 25730190 |
| Hodgkin Disease, Relapsing course | Stem Cell Exhaustion | Relapsed or refractory (R/R) classical Hodgkin lymphoma (cHL) after autologous stem cell transplantation (ASCT) remains a challenge. | 25734915 |
| Thrombotic Microangiopathies | Stem Cell Exhaustion | Hematopoietic stem cell transplantation-associated thrombotic microangiopathy accompanied by renal arteriolar C4d deposition. | 25735190 |
| Mycoses | Stem Cell Exhaustion | Incidence and risk factors of probable and proven invasive fungal infection in adult patients receiving allogeneic hematopoietic stem cell transplantation. | 25735797 |
| Mycoses | Stem Cell Exhaustion | To investigate the incidence and risk factors for the occurrence of proven or probable invasive fungal infection (IFI) in adult patients receiving allogeneic hematopoietic stem cell transplantation (HSCT). | 25735797 |
| Leukemia, Myelomonocytic, Chronic, PAFAH1B1 wt Allele | Stem Cell Exhaustion | Outcome of patients with high risk MDS and CMML who failed treatment with azacitidine remains poor with a median survival of 6 months, without established therapy available except allogeneic hematopoietic stem cell transplantation. | 25735917 |
| Specialty Type - cancer | Stem Cell Exhaustion | We also investigated changes in the CD24(+)/44(+) population that may be involved in chemoresistance, as this population likely includes cancer stem cells. | 25736055 |
| Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | Stem Cell Exhaustion | In this phase 3 trial, we randomly assigned 487 adults with newly diagnosed mantle-cell lymphoma who were ineligible or not considered for stem-cell transplantation to receive six to eight 21-day cycles of R-CHOP intravenously on day 1 (with prednisone administered orally on days 1 to 5) or VR-CAP (R-CHOP regimen, but replacing vincristine with bortezomib at a dose of 1.3 mg per square meter of body-surface area on days 1, 4, 8, and 11). | 25738670 |
| Failure, Mantle cell lymphoma, Specialty Type - cancer | Stem Cell Exhaustion | Repeated relapses leading to treatment failure in patients with mantle cell lymphoma might suggest the presence of cancer stem cells. | 25739938 |
| Specialty Type - cancer | Stem Cell Exhaustion | A small cell population with CD45+/CD19 - was previously reported to represent cancer stem cells. | 25739938 |
| Pulmonary Complication, Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Impact of body mass index on pulmonary complications in patients with non-Hodgkin lymphoma treated with hematopoietic stem cell transplant. | 25739939 |
| Pulmonary Complication | Stem Cell Exhaustion | The objective of this study was to examine the association between body mass index (BMI) and the incidence of pulmonary complications (PCs) after hematopoietic stem cell transplant (HCT). | 25739939 |
| Graft-vs-Host Disease, Stable chronic Graft vs Host Disease, physiopathological | Stem Cell Exhaustion | At least half of patients with chronic graft-versus-host-disease (cGVHD), the leading cause of morbidity and non-relapse mortality after allogeneic stem cell transplantation, have oral manifestations: mucosal lesions, salivary dysfunction, and limited mouth-opening. | 25740857 |
| Meningitis | Stem Cell Exhaustion | This report describes a case of meningitis caused by Listeria monocytogenes in a stem cell transplant recipient on immunosuppressive therapy for cutaneous chronic graft-versus host disease. | 25742155 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | A 59-year-old woman had undergone allogeneic stem cell transplantation (from a matched unrelated donor) 13 months previously for chronic lymphocytic leukemia. | 25742155 |
| Aspergillus Galactomannan Antigen Test | Stem Cell Exhaustion | False-positive Aspergillus galactomannan and its kinetics in allogeneic hematopoietic stem cell transplantation. | 25743584 |
| Aspergillus Galactomannan Antigen Test | Stem Cell Exhaustion | We evaluated the incidence of and risk factors for false-positive Aspergillus galactomannan (GM) antigenemia in allogeneic hematopoietic stem cell transplantation (HSCT). | 25743584 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | [Usefulness of quantitative PCR in biopsy specimens for early therapeutic intervention in gastro-intestinal cytomegalovirus infections after allogeneic stem cell transplantation]. | 25744040 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | Gastro-intestinal cytomegalovirus infection (GI-CMV), which occurs after allogeneic stem cell transplantation (allo-SCT), is diagnosed by immunostaining of biopsied tissues obtained using a fiberscope. | 25744040 |
| Hypertrophic Cardiomyopathy | Stem Cell Exhaustion | Circulating mesenchymal stem cells in patients with hypertrophic cardiomyopathy. | 25744383 |
| Hypertrophic Cardiomyopathy, Health maintenance | Stem Cell Exhaustion | This study examines the mobilization of mesenchymal stem cells (MSCs) in patients with hypertrophic cardiomyopathy (HCM) compared to healthy individuals. | 25744383 |
| Interstitial Cystitis | Stem Cell Exhaustion | Mesenchymal Stem Cell Therapy Alleviates Interstitial Cystitis by Activating Wnt Signaling Pathway. | 25745847 |
| Multiple Myeloma | Stem Cell Exhaustion | A 63-year-old male with multiple myeloma (IgD-l) received autologous peripheral blood stem cell transplantation (PBSCT) after induction of VAD in March 2008, and obtained a very good partial response. | 25745970 |
| Parkinson Disease | Stem Cell Exhaustion | Human induced pluripotent stem cell-derived neurons improve motor asymmetry in a 6-hydroxydopamine-induced rat model of Parkinson's disease. | 25747741 |
| palladium, Parkinson Disease | Stem Cell Exhaustion | Since human embryonic stem cells and human fetal neural stem cells have immune rejection and ethical issues, recent advancements in induced pluripotent stem cells (iPS cells) provide new possibilities to study autologous cell therapy for Parkinson's disease (PD). | 25747741 |
| palladium | Stem Cell Exhaustion | We isolated human skin fibroblasts from normal individuals and patients with PD; we generated iPS cells by transfecting these human skin fibroblasts with retroviral reprogramming factors of OCT4, SOX2, KLF4 and c-MYC and induced iPS cells to differentiate neural stem cells (NSCs) and then into neurons and dopamine neurons in vitro. | 25747741 |
| Clostridium difficile colitis, Peripheral Stem Cell Transplantation, Acute GVH disease, Aspergillosis | Stem Cell Exhaustion | Acute graft-versus-host disease, invasive aspergillosis and Clostridium difficile colitis after peripheral blood stem cell transplantation: A complex network of causalities and a challenge for prevention. | 25749258 |
| Graft-vs-Host Disease, Central Diabetes Insipidus | Stem Cell Exhaustion | We report a case of a 58-years-old patient who developed an IA within a protected room, CDI and GVHD after allogeneic allogeneic peripheral blood stem cell transplantation (PBSCT). | 25749258 |
| Mycoses | Stem Cell Exhaustion | Safety and efficacy of micafungin for prophylaxis against invasive fungal infections in Japanese patients undergoing hematopoietic stem cell transplantation: Results of a post-marketing surveillance study. | 25749360 |
| Mycoses | Stem Cell Exhaustion | Invasive fungal infections are a major cause of morbidity and mortality in patients with hematopoietic stem cell transplantation. | 25749360 |
| Mycoses | Stem Cell Exhaustion | A prospective multicenter post-marketing observational surveillance study was conducted from July 2007 to June 2010 to assess the safety and efficacy of micafungin, an echinocandin antifungal, for prophylaxis against invasive fungal infections in Japanese patients undergoing hematopoietic stem cell transplantation. | 25749360 |
| Mycoses | Stem Cell Exhaustion | In conclusion, micafungin had sufficient safety and efficacy for prophylaxis against invasive fungal infections in Japanese patients with various backgrounds undergoing hematopoietic stem cell transplantation. | 25749360 |
| Anemia | Stem Cell Exhaustion | Haematopoietic progenitor cells show special sensitivity to mitochondrial DNA (mtDNA) mutagenesis, which suggests that increased mtDNA mutagenesis could underlie anemias. | 25751021 |
| Abdominal Neoplasms, Neoplasms, epinephrine, niobium | Stem Cell Exhaustion | A 4-year-old, female patient with a high risk adrenal NB was found to have a 2.9-cm, right thyroid nodule on surveillance chest computed tomography (CT) 6 months after completion of her NB treatment (induction chemotherapy, tumor resection, autologous stem cell transplantation, external beam radiation to the abdominal tumor site, immunotherapy, and retinoic acid). | 25751324 |
| Multiple Myeloma | Stem Cell Exhaustion | G-CSF plus preemptive plerixafor vs hyperfractionated CY plus G-CSF for autologous stem cell mobilization in multiple myeloma: effectiveness, safety and cost analysis. | 25751646 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | The optimal stem cell mobilization regimen for patients with multiple myeloma (MM) remains undefined. | 25751646 |
| Toxic effect | Stem Cell Exhaustion | The chemo-mobilization approach was associated with twofold stem cell yield, slightly lower cost but significantly increased toxicity. | 25751646 |
| Doctor of Chiropractic | Stem Cell Exhaustion | Here we show that epigenetic regulator and central transcriptional instructor in adult stem cells, Bmi1, protects against DCM by repressing cardiac senescence. | 25751743 |
| Multiple Myeloma | Stem Cell Exhaustion | The role of positron emission tomography with 18F-fluorodeoxyglucose integrated with computed tomography in the evaluation of patients with multiple myeloma undergoing allogeneic stem cell transplantation. | 25754658 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Positron emission tomography (PET) integrated with computed tomography (PET/CT) has been reported to be useful for screening myelomatous lesions at diagnosis in patients with multiple myeloma (MM) and for monitoring response to autologous stem cell transplantation (auto-SCT). | 25754658 |
| Hypoxia | Stem Cell Exhaustion | Pre-clinical studies have shown that hypoxia preconditioning can enhance stem cell therapeutic potential for myocardial repair. | 25755063 |
| Specialty Type - cancer, Thyroid carcinoma | Stem Cell Exhaustion | Expression of cancer stem cell markers and epithelial-mesenchymal transition-related factors in anaplastic thyroid carcinoma. | 25755746 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cell markers such as CD133 and nestin were more highly expressed in ATC than PTC (52.9% versus 5%, 52.9% versus 0%, respectively). | 25755746 |
| Specialty Type - cancer | Stem Cell Exhaustion | We used immunohistochemistry to examine the expression of multiple markers of cancer stem cells and EMT-activating transcriptional factors. | 25755746 |
| Primary immune deficiency disorder | Stem Cell Exhaustion | Long-lasting production of new T and B cells and T-cell repertoire diversity in patients with primary immunodeficiency who had undergone stem cell transplantation: a single-centre experience. | 25756054 |
| Primary immune deficiency disorder | Stem Cell Exhaustion | Levels of Kappa-deleting recombination excision circles (KRECs), T-cell receptor excision circles (TRECs), and T-cell repertoire diversity were evaluated in 1038 samples of 124 children with primary immunodeficiency, of whom 102 (54 with severe combined immunodeficiency and 48 with other types of immunodeficiency) underwent hematopoietic stem cell transplantation. | 25756054 |
| Connective Tissue Diseases, Diabetes, Head and neck structure, Hepatitis C, Benign prostatic hypertrophy, Post-Traumatic Stress Disorder | Stem Cell Exhaustion | The following independent risk factors showed significant association with DES: diabetes (odds ratio [OR], 1.408; 95% confidence interval [CI], 1.031 to 1.924), hepatitis C (OR, 3.326; 95% CI, 1.632 to 6.776); connective tissue disease (OR, 2.157; 95% CI, 1.679 to 2.771), benign prostatic hyperplasia (OR, 3.892; 95% CI, 2.476 to 6.116), rosacea (OR, 3.747; 95% CI, 1.972 to 7.120), posttraumatic stress disorder (OR, 1.449; 95% CI, 1.043 to 2.013), hematopoietic stem cell transplantation (OR, 7.269; 95% CI, 2.312 to 22.849), head and neck radiotherapy (OR, 8.776; 95% CI, 3.096 to 24.873), postmenopausal estrogen therapy (OR, 1.912; 95% CI, 1.160 to 3.151), antihistamines (OR, 2.040; 95% CI, 1.516 to 2.746), antidepressants (OR, 1.982; 95% CI, 1.077 to 3.647), contact lenses (OR, 2.366; 95% CI, 1.266 to 4.423), and video display terminal exposure for more than 6 h/d (OR, 2.275; 95% CI, 1.451 to 3.568). | 25756335 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | We report a case of limbal stem cell deficiency that occurred in a patient receiving chemotherapy using S-1 alone for gastric cancer. | 25756340 |
| Rotator Cuff Injuries, Tears body substance | Stem Cell Exhaustion | While the use of bone marrow concentrate (BMC) has been described in the treatment of rotator cuff tears, the impact of a rotator cuff injury on the mesenchymal stem cells (MSCs) content present in the human shoulder has not been determined, especially with regard to changes in the levels of MSCs at the tendon-bone interface. | 25757411 |
| Hemoglobinuria, Paroxysmal nocturnal hemoglobinuria, Hemolysis (biological function), Thrombosis | Stem Cell Exhaustion | Paroxysmal nocturnal haemoglobinuria (PNH) is a rare acquired haematopoietic stem cell disorder characterised by persistent haemolysis and platelet activation, severe end-organ damage, an increased risk of thrombosis and early mortality. | 25757938 |
| Lymphoma, leukemia | Stem Cell Exhaustion | The burden of care and quality of life of caregivers of leukemia and lymphoma patients following peripheric stem cell transplantation. | 25758128 |
| Lymphoma, leukemia | Stem Cell Exhaustion | This study was conducted to identify the burden of care and quality of life of caregivers of leukemia and lymphoma patients who had undergone peripheric stem cell transplantation. | 25758128 |
| Hematoma, Cerebrovascular accident | Stem Cell Exhaustion | Cervical epidural hematoma in a healthy donor presenting stroke mimic symptoms: a rare adverse event following peripheral blood stem cell apheresis. | 25759485 |
| Numbness, Usual Severity Pain | Stem Cell Exhaustion | A female sibling donor, aged 61 years with an unremarkable medical history, complained of pain in the left neck and shoulder and numbness in the left upper limb 1 h after the end of peripheral blood stem cell apheresis. | 25759485 |
| Brain Infarction, Hematoma | Stem Cell Exhaustion | This report is the first case of cervical epidural hematoma in a healthy donor who underwent peripheral blood stem cell apheresis and presented symptoms confusingly similar to those of brain infarction. | 25759485 |
| Amyotrophic Lateral Sclerosis | Stem Cell Exhaustion | A comprehensive library of familial human amyotrophic lateral sclerosis induced pluripotent stem cells. | 25760436 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Safety and efficacy of granulocyte colony-stimulating factor biosimilars in engraftment after autologous stem cell transplantation for haematological malignancies: a 4-year, single institute experience with different conditioning regimens. | 25761321 |
| Infantile encephalopathy | Stem Cell Exhaustion | Unrelated donor hematopoietic stem cell transplantation for infantile enteropathy due to IL-10/IL-10 receptor defect. | 25761563 |
| NBN wt Allele | Stem Cell Exhaustion | PSY measurement in DBS could serve as a 2nd tier assay in NBS for KD, simplify and reduce the cost of follow up protocols, help determine disease progression, and be used to monitor KD patients following hematopoietic stem cell transplantation. | 25762404 |
| Neoplasms | Stem Cell Exhaustion | Both modalities allow accurate localization of disease after chemotherapy or autologous stem cell transplantation and can provide important prognostic information that can influence further clinical decision making regarding therapy, particularly when tumor serum markers may be a less reliable indicator of disease burden after repeated treatments. | 25763728 |
| Alzheimers Disease | Stem Cell Exhaustion | Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks. | 25765079 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | An effective graft-versus-host disease (GVHD) preventative approach that preserves the graft-versus-tumor effect after allogeneic hematopoietic stem cell transplantation (HSCT) remains elusive. | 25765556 |
| Graft-vs-Host Disease, leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The impact of graft-versus-host disease prophylaxis in reduced-intensity conditioning allogeneic stem cell transplant in acute myeloid leukemia: a study from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation. | 25769546 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | This study addresses this issue in 228 adult patients above 50 years of age with acute myeloid leukemia in first complete remission given peripheral blood stem cells from HLA-identical siblings after fludarabine and 2 days of intravenous busulfan reduced-intensity conditioning. | 25769546 |
| End Stage Liver Disease | Stem Cell Exhaustion | We aimed to evaluate clinical therapeutic effects of human umbilical cord-derived mesenchymal stem cell (UCMSC) transplantation in the treatment of end-stage liver diseases. | 25769583 |
| End Stage Liver Disease | Stem Cell Exhaustion | Clinical therapeutic effects of human umbilical cord-derived mesenchymal stem cells transplantation in the treatment of end-stage liver disease. | 25769583 |
| Infection, Neoplasms | Stem Cell Exhaustion | Early lymphocyte recovery after allogeneic hematopoietic stem cell transplantation (HSCT) is related to the prevention of serious infections and the clearing of residual tumor cells. | 25769599 |
| Febrile Neutropenia, Specialty Type - cancer | Stem Cell Exhaustion | Febrile neutropenic infection occurred in cancer patients undergoing autologous peripheral blood stem cell transplantation. | 25769601 |
| Fever, Specialty Type - cancer | Stem Cell Exhaustion | The objective of this study was to investigate the incidence, risk factors, and clinical and prognostic characteristics of febrile infection that occurred during the neutropenic period in cancer patients who underwent autologous peripheral blood stem cell transplantation (APBSCT). | 25769601 |
| Osteoporosis | Stem Cell Exhaustion | Comprehensive transcriptome analysis of mesenchymal stem cells in elderly patients with osteoporosis. | 25771989 |
| Osteoporosis | Stem Cell Exhaustion | To explore the role of aging in the pathogenesis of osteoporosis, several differentially expressed genes (DEGs) and altered biological pathways were identified in mesenchymal stem cells (MSCs) in elderly patients with osteoporosis. | 25771989 |
| Hematologic Neoplasms | Stem Cell Exhaustion | In patients with hematologic malignancies, who underwent their first myeloablative allogeneic hematopoietic cell transplantation, PGF was reported in 1278 (5.5%), and there was a marked difference in PGFs using peripheral blood stem cell compared with bone marrow grafts (2.5 vs 7.3%; P<0.001). | 25772027 |
| Ischemic cardiomyopathy | Stem Cell Exhaustion | The graft of stem cells to treat ischemic cardiomyopathy is popular in many clinical trials. | 25773139 |
| Lupus Erythematosus, Systemic | Stem Cell Exhaustion | Endoplasmic reticulum stress participates in the progress of senescence of bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. | 25773452 |
| Lupus Erythematosus, Encephalitis, St. Louis | Stem Cell Exhaustion | Previous studies suggested that the senescence of bone marrow mesenchymal stem cells (BM-MSCs) played an important role in the pathological process of systemic lupus erythematosus (SLE). | 25773452 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation in very high risk CLL or early relapsed disease has become less important than in the past. | 25776793 |
| Alopecia | Stem Cell Exhaustion | Clinical use of conditioned media of adipose tissue-derived stem cells in female pattern hair loss: a retrospective case series study. | 25777970 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Patients with high-risk hematologic malignancies received myeloablative therapy followed by transplantation with 2 CB units, one of which was treated ex vivo for 30 minutes with the enzyme fucosyltransferase-VI and guanosine diphosphate fucose to enhance the interaction of CD34(+) stem and early progenitor cells with microvessels. | 25778529 |
| Rheumatoid Arthritis | Stem Cell Exhaustion | Red cell distribution width is associated with endothelial progenitor cell depletion and vascular-related mediators in rheumatoid arthritis. | 25778627 |
| Rheumatoid Arthritis, Inflammation, Cape Verde | Stem Cell Exhaustion | Since inflammation and Endothelial Progenitor Cells (EPCs) imbalance have been reported in RA patients to be related to CV disease, we wondered whether RDW could be linked to endothelial repair failure in RA. | 25778627 |
| Bone Diseases | Stem Cell Exhaustion | Understanding the mechanisms by which bone marrow mesenchymal stem cells (BMSCs) differentiate into bone-forming osteoblasts and marrow adipocytes is crucial to develop strategies for the treatment of several bone diseases. | 25779338 |
| Fracture | Stem Cell Exhaustion | Increased incidence of fractures in recipients of hematopoietic stem-cell transplantation. | 25779562 |
| Non-Malignant | Stem Cell Exhaustion | The number of long-term survivors after hematopoietic stem-cell transplantation (HSCT) for malignant and nonmalignant disorders is increasing, and late effects are gaining importance. | 25779562 |
| Cessation of life | Stem Cell Exhaustion | Interestingly, we found that direct adenosine treatment is sufficient to induce embryonic stem cell-derived motor neuron (ESMN) cell death in cultures. | 25779930 |
| Refractory Cytopenia of Childhood | Stem Cell Exhaustion | Furthermore, TIM-3 rendered RCC cells with the ability to induce resistance to sunitinib and mTOR inhibitors, the standard regimen for patients with ccRCC, as well as stem cell activities. | 25783986 |
| Depression, CTCAE, Anxiety Disorders, Acute Coronary Syndrome | Stem Cell Exhaustion | Influence of depression and anxiety on circulating endothelial progenitor cells in patients with acute coronary syndromes. | 25784019 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | Circulating endothelial progenitor cells (EPCs) are related to endothelial function and progression of coronary artery disease. | 25784019 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The optimal intensity of conditioning for allogeneic hematopoietic stem cell transplantation (HCT) in acute myeloid leukemia (AML) remains undefined. | 25784222 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Outcome of acute myeloid leukemia patients with pulmonary nodules of uncertain etiology receiving allogeneic hematopoietic progenitor cell transplant. | 25784319 |
| Infection, Communicable Diseases | Stem Cell Exhaustion | They pose potential challenges to successful hematopoietic progenitor cell (HPC) transplant as they may be niches for infection reactivation or sites susceptible to subsequent infections. | 25784319 |
| Multiple Myeloma | Stem Cell Exhaustion | Dose-intensified bendamustine followed by autologous peripheral blood stem cell support in relapsed and refractory multiple myeloma with impaired bone marrow function. | 25784529 |
| Toxic effect, Hematopoiesis | Stem Cell Exhaustion | We hypothesized that dose-intensified bendamustine (180 mg/m2 , day 1 and 2) followed by autologous blood stem cell support (ASCS) would improve bone marrow function with low post-transplant toxicity in patients with severely impaired haematopoiesis. | 25784529 |
| Primary Myelofibrosis | Stem Cell Exhaustion | Impact of allogeneic stem cell transplantation on survival of patients less than 65 years of age with primary myelofibrosis. | 25784679 |
| Primary Myelofibrosis, PMF Regimen | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (SCT) is the only curative option for patients with primary myelofibrosis (PMF), but information on its net advantage over conventional therapies is lacking. | 25784679 |
| Specialty Type - cancer, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Cancer stem cells (CSCs, also called cancer stem-like cells, CSLCs) can function as "seed cells" for tumor recurrence and metastasis. | 25788271 |
| Liver carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Increased Expression of Circulating Cancer Stem Cell Markers During the Perioperative Period Predicts Early Recurrence After Curative Resection of Hepatocellular Carcinoma. | 25791790 |
| Liver carcinoma, Hollings Cancer Center, Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | This study was designed to investigate the correlation between postoperative recurrence of hepatocellular carcinoma (HCC) and perioperative expression and dynamic changes in cancer stem cell (CSC) markers in tumors and peripheral blood. | 25791790 |
| Neoplasms, leukemia | Stem Cell Exhaustion | Expression of Robo4 was recently found in solid tumors and leukemia stem cells. | 25794001 |
| Neoplasms | Stem Cell Exhaustion | Robo4 is involved in hematopoietic stem/progenitor cell homeostasis and essential for tumor angiogenesis. | 25794001 |
| Complication Aspects, Diabetes | Stem Cell Exhaustion | Percutaneous injection of bone marrow mesenchymal stem cells for ankle non-unions decreases complications in patients with diabetes. | 25795249 |
| diabetic | Stem Cell Exhaustion | Eighty-six ankle non-union in diabetic patients were treated with bone marrow mesenchymal stem cells (BM-MSCs) delivered in an autologous bone marrow concentrate (BMC). | 25795249 |
| Liver Cirrhosis | Stem Cell Exhaustion | REpeated AutoLogous Infusions of STem cells In Cirrhosis (REALISTIC): a multicentre, phase II, open-label, randomised controlled trial of repeated autologous infusions of granulocyte colony-stimulating factor (GCSF) mobilised CD133+ bone marrow stem cells in patients with cirrhosis. | 25795699 |
| Hepatobiliary Disorder | Stem Cell Exhaustion | Primary objective is to demonstrate an improvement in the severity of liver disease over 3 months using either G-CSF alone or G-CSF followed by repeated infusions of haematopoietic stem cells compared with standard conservative management. | 25795699 |
| Malignant neoplasm of nasopharynx | Stem Cell Exhaustion | Safety and efficacy study of nasopharyngeal cancer stem cell vaccine. | 25796196 |
| Malignant neoplasm of nasopharynx | Stem Cell Exhaustion | In this trial, nasopharyngeal cancer stem cells (CSCs) were separated and cultured to produce a vaccine; its safety and efficacy were prospectively evaluated in low-, medium-, and high-dose groups. | 25796196 |
| Hodgkin Disease | Stem Cell Exhaustion | Brentuximab vedotin as consolidation therapy after autologous stem-cell transplantation in patients with Hodgkin's lymphoma at risk of relapse or progression (AETHERA): a randomised, double-blind, placebo-controlled, phase 3 trial. | 25796459 |
| Hodgkin Disease | Stem Cell Exhaustion | High-dose therapy followed by autologous stem-cell transplantation is standard of care for patients with relapsed or primary refractory Hodgkin's lymphoma. | 25796459 |
| Hodgkin Disease | Stem Cell Exhaustion | Patients with unfavourable-risk relapsed or primary refractory classic Hodgkin's lymphoma who had undergone autologous stem-cell transplantation were randomly assigned, by fixed-block randomisation with a computer-generated random number sequence, to receive 16 cycles of 1*8 mg/kg brentuximab vedotin or placebo intravenously every 3 weeks, starting 30-45 days after transplantation. | 25796459 |
| Hodgkin Disease | Stem Cell Exhaustion | Early consolidation with brentuximab vedotin after autologous stem-cell transplantation improved progression-free survival in patients with Hodgkin's lymphoma with risk factors for relapse or progression after transplantation. | 25796459 |
| Pancreatic Ductal Adenocarcinoma, ANOPHTHALMIA AND PULMONARY HYPOPLASIA | Stem Cell Exhaustion | Stem cell factor (SCF) and hypoxia-inducible factor-1a (HIF-1a) both have important functions in pancreatic ductal adenocarcinoma (PDAC). | 25799412 |
| Neutropenia, Kidney Failure, Sepsis, Central Diabetes Insipidus | Stem Cell Exhaustion | Multivariate analysis revealed that age >65 years (OR, 1.13), male gender (OR, 1.14), prolonged LOS, admission to teaching hospital (OR, 1.16), complications of sepsis (OR, 1.83), neutropenia (OR, 1.35), renal failure (OR, 1.18), and bone marrow or stem cell transplantation (OR, 1.27) were significantly associated with CDI occurrence. | 25801085 |
| Deficit | Stem Cell Exhaustion | Allogeneic hematopoietic stem-cell transplantation (alloHSCT) survivors treated with total body irradiation (TBI) exhibit bone deficits and excess adiposity, potentially related to altered mesenchymal stem cell differentiation into osteoblasts or adipocytes. | 25801428 |
| Autoimmune Diseases | Stem Cell Exhaustion | It is associated with many drugs and diseases including chemotherapy, hematopoietic stem cell transplantation, and autoimmune disorders. | 25802198 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | A retrospective chart review included adult allogeneic hematopoietic stem cell patients who received tacrolimus for graft-versus-host disease prophylaxis in 2012. | 25802301 |
| Specialty Type - cancer | Stem Cell Exhaustion | Lgr5 expression was not associated with the expression of tested cancer stem cell markers. | 25804119 |
| Specialty Type - cancer | Stem Cell Exhaustion | Based on the lack of correlation between Lgr5 and tested cancer stem cell markers, Lgr5 does not seem to be a potential stemness marker or prognostic factor in PDAC. | 25804119 |
| Specialty Type - cancer, Pancreatic carcinoma | Stem Cell Exhaustion | Lgr5 expression, cancer stem cells and pancreatic cancer: results from biological and computational analyses. | 25804119 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | SD44+/CD24- markers of cancer stem cells in patients with breast cancer of different molecular subtypes. | 25804234 |
| Neoplasms, Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | To determine frequency of tumors with immunohistochemical markers of cancer stem cells (CSC) CD44+/CD24- in patients with breast cancer (BC) of different molecular subtype and to evaluate their prognostic value. | 25804234 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Allogeneic stem cell transplant may improve the outcome of adult patients with inv(16) acute myeloid leukemia in first complete remission with poor molecular responses to chemotherapy. | 25804769 |
| Anorectal fistula | Stem Cell Exhaustion | To study the results of stem-cell therapy under a Compassionate-use Program for patients with recurrent anal fistulae. | 25805941 |
| Anorectal fistula | Stem Cell Exhaustion | Under controlled circumstances, and approved by European and Spanish laws, a Compassionate-use Program allows the use of stem-cell therapy for patients with very complex anal fistulae. | 25805941 |
| Anorectal fistula | Stem Cell Exhaustion | Recurrent anal fistulae: limited surgery supported by stem cells. | 25805941 |
| Anorectal fistula | Stem Cell Exhaustion | Stem cells are safe and useful for treating anal fistulae. | 25805941 |
| Adult Glioblastoma | Stem Cell Exhaustion | Paracrine effects of mesenchymal stem cells induce senescence and differentiation of glioblastoma stem-like cells. | 25806680 |
| Neoplasms | Stem Cell Exhaustion | Since mesenchymal stem cells (MSCs) display high tumor tropism, we examined possible antitumor effects of the secreted factors from human MSCs on four GSLC lines (NCH421k, NCH644, NIB26, and NIB50). | 25806680 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | Hematopoietic stem cell transplantation from anti-cytomegalovirus immunoglobulin G (anti-CMV-IgG) positive donors facilitated immunological recovery post-transplant, which may indicate that chronic CMV infection has an effect on the immune system. | 25807050 |
| Hematologic Neoplasms | Stem Cell Exhaustion | We evaluated the composition of lymphocytes at hematologic recovery in 99 patients with hematologic malignancies post hematopoietic stem cell transplantation (HSCT). | 25807050 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Following the recognition that hematopoietic stem cells improve the outcome of myocardial infarction in animal models, bone marrow mononuclear cells, CD34-positive cells, and mesenchymal stromal cells have been introduced clinically. | 25807105 |
| Disease | Stem Cell Exhaustion | However, the identification of resident cardiac stem cells in the human heart (hCSCs) has created great expectation concerning the potential implementation of this category of autologous cells for the management of the human disease. | 25807105 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Thiotepa-based versus total body irradiation-based myeloablative conditioning prior to allogeneic stem cell transplantation for acute myeloid leukaemia in first complete remission: a retrospective analysis from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation. | 25807864 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | This retrospective matched-pair analysis evaluated the outcome of adults with acute myeloid leukaemia in first complete remission who received myeloablative conditioning either with a thiotepa-based (n = 121) or a cyclophosphamide/total body irradiation-based (TBI; n = 358) regimen for allogeneic hematopoietic stem cell transplantation from an HLA-matched sibling or an unrelated donor. | 25807864 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Specific Preferences in Lineage Choice and Phenotypic Plasticity of Glioma Stem Cells Under BMP4 and Noggin Influence. | 25808628 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Although BMP4-induced differentiation of glioma stem cells (GSCs) is well recognized, details of the cellular responses triggered by this morphogen are still poorly defined. | 25808628 |
| leukemia | Stem Cell Exhaustion | Haploidentical stem cell transplantation in patients aged 50 yr and older with leukemia: similar outcomes compared to younger adults. | 25809115 |
| Tuberculosis, Pulmonary | Stem Cell Exhaustion | Mycobacterium tuberculosis-specific and MHC class I-restricted CD8+ T-cells exhibit a stem cell precursor-like phenotype in patients with active pulmonary tuberculosis. | 25809750 |
| Specialty Type - cancer | Stem Cell Exhaustion | All nine niches expressed stromal-derived factor-1a (SDF-1a), its receptor C-X-C chemokine receptor type 4 (CXCR4), osteopontin and cathepsin K. SDF-1a plays a role in homing of CXCR4+ stem cells and leukocytes, whereas osteopontin and cathepsin K promote migration of cancer cells and leukocytes. | 25809793 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | CMV antigenemia tests were ordered in 58 patients depending on the clinical context, and the incidence of CMV reactivation and proven/suspected CMV disease requiring antiviral therapy was 20% (24 of 120) and 11% (13 of 120) respectively, including those without stem cell transplantation (SCT). | 25810117 |
| Molecular | Stem Cell Exhaustion | To identify molecular defects contributing to metabolic dysregulation in DS in the undifferentiated state, we generated mesenchymal progenitor cells (MPCs) from induced pluripotent stem cells derived from a 4-week-old female with DS and a healthy newborn male (control). | 25811318 |
| Hypocalcemia | Stem Cell Exhaustion | Reliance solely on hematopoietic stem cell transplantation can leave hypocalcemia uncorrected with sometimes fatal consequences. | 25811986 |
| Extramedullary Plasmacytoma, Multiple Myeloma | Stem Cell Exhaustion | The t(11;14)(q13;q32) translocation as a poor prognostic parameter for autologous stem cell transplantation in myeloma patients with extramedullary plasmacytoma. | 25812994 |
| Extramedullary Plasmacytoma, Multiple Myeloma, MAEA gene, Morular Metaplasia of the Endometrium, Chromosome Aberrations | Stem Cell Exhaustion | However, there are few data about the prognostic significance of cytogenetic abnormalities for autologous stem cell transplantation (ASCT) in multiple myeloma (MM) patients with extramedullary plasmacytoma (EMP). | 25812994 |
| Specialty Type - cancer, Hollings Cancer Center | Stem Cell Exhaustion | Methylation of 24 genes and expression of 22 cancer stem cell (CSC) biomarkers were quantitatively measured in 10 paired primary and recurrent HCC specimens. | 25815780 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | Lung fibroblasts share mesenchymal stem cell features which are altered in chronic obstructive pulmonary disease via the overactivation of the Hedgehog signaling pathway. | 25815884 |
| Chronic Obstructive Airway Disease, Lung Neoplasms | Stem Cell Exhaustion | We investigated the stem cell features and the expression of Hedgehog components in human lung fibroblasts isolated from histologically-normal parenchymal tissue from 25 patients--8 non-smokers/non-COPD, 8 smokers-non COPD and 9 smokers with COPD--who were undergoing surgery for lung tumor resection. | 25815884 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | Our study reveals that lung fibroblasts possess mesenchymal stem cell-features which are impaired in COPD via the contribution of an abnormal Hedgehog signaling. | 25815884 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | We found that lung fibroblasts resemble mesenchymal stem cells in terms of cell surface marker expression, differentiation ability and immunosuppressive potential and that these properties were altered in lung fibroblasts from smokers and even more in COPD patients. | 25815884 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | Primary treatment response rather than front line stem cell transplantation is crucial for long term outcome of peripheral T-cell lymphomas. | 25815886 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Mortality patterns among recipients of autologous hematopoietic stem cell transplantation for lymphoma and myeloma in the past three decades. | 25816932 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Understanding the mortality patterns of patients with lymphoma and myeloma, who have undergone autologous hematopoietic stem cell transplantation (ASCT) might identify improvement opportunities. | 25816932 |
| Hemorrhage | Stem Cell Exhaustion | Incidence and risk factors for life-threatening bleeding after allogeneic stem cell transplant. | 25817436 |
| Hemorrhage | Stem Cell Exhaustion | Bleeding is a frequent complication after allogeneic haematopoietic stem cell transplantation (HSCT) and may affect survival. | 25817436 |
| Pericardial Effusion, CTCAE | Stem Cell Exhaustion | Risk factors for pericardial effusion in adult patients receiving allogeneic haematopoietic stem cell transplantation. | 25818840 |
| Pericardial Effusion, CTCAE | Stem Cell Exhaustion | Pericardial effusion (PE) is a rare but potentially life-threatening complication for allogeneic haematopoietic stem cell transplantation (HSCT) recipients. | 25818840 |
| Septicemia | Stem Cell Exhaustion | After hematopoietic stem cell transplantation from a full-matched sibling was performed, the patient expired due to graft failure and septicemia. | 25818969 |
| Aplastic Anemia | Stem Cell Exhaustion | In aplastic anaemia (AA), haemopoietic activity is significantly reduced and generally attributed to failure of haemopoietic stem cells (HSC) within the bone marrow (BM). | 25819548 |
| Aneuploidy | Stem Cell Exhaustion | Here, we analyze the response of primary human cells and murine hematopoietic stem cells (HSCs) to aneuploidy induction and the role of telomeres and the telomerase in this process. | 25820263 |
| Specialty Type - cancer | Stem Cell Exhaustion | Thirty-two oral presentations were delivered on various themes, such as therapeutic agents, cancer stem cells, EMT signaling, molecular epidemiology, cellular senescence, and clinical research, to more than 80 participants. | 25820597 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Treatment of Knee Osteoarthritis With Allogeneic Bone Marrow Mesenchymal Stem Cells: A Randomized Controlled Trial. | 25822648 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Decitabine as a conditioning regimen in haploidentical stem cell transplantation for refractory acute myeloid leukaemia. | 25825260 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Chemotherapy can increase treatment-related mortality associated with future haematopoietic stem cell transplantation (HSCT) for patients with relapsed/refractory acute myeloid leukaemia (AML). | 25825260 |
| Graft-vs-Host Disease, Cataract | Stem Cell Exhaustion | To study the outcomes of cataract surgery in patients with graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). | 25826324 |
| Pulmonary arterial hypertension, Unknown (origin) (qualifier value) | Stem Cell Exhaustion | Elevated serum levels of macrophage migration inhibitory factor and stem cell growth factor b in patients with idiopathic and systemic sclerosis associated pulmonary arterial hypertension. | 25829187 |
| Spinal Cord Injuries | Stem Cell Exhaustion | Stem cell growth factor b (SCGF b) is a human growth factor that, together with MIF, is involved in the pathogenesis of chronic spinal cord injury. | 25829187 |
| Infection | Stem Cell Exhaustion | Invasive mold infections (IMI) are among the most devastating complications following chemotherapy and hematopoietic stem cell transplantation (HSCT), with high mortality rates. | 25835547 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Aldehyde dehydrogenase 1 (ALDH-1) is a cancer stem cell marker whose overexpression can predict the prognosis of several human cancers. | 25837433 |
| Specialty Type - cancer | Stem Cell Exhaustion | This study indicates that the reduction of the cancer stem cell population via chemoradiotherapy may not be sufficient to improve patient survival. | 25837433 |
| Malignant tumor of cervix, Neoplasms | Stem Cell Exhaustion | Twenty-nine of the 74 cervical cancer cases exhibited ALDH-1 expression (39.19 %) in the pre-treatment tissue samples; however, only 19 of these 39 cases exhibited ALDH-1 expression (48.72 %) in post-treatment tissue samples, indicating that chemoradiotherapy eliminated the ALDH-1 positive tumor stem cells in cervical cancer. | 25837433 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | To clarify the clinical impact of prior use of azacitidine (AZA) on outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for myelodysplastic syndrome (MDS), we retrospectively reviewed the clinical outcomes of 15 MDS patients who were treated with AZA before allo-HSCT (AZA group). | 25837848 |
| Neoplasms | Stem Cell Exhaustion | Nestin is a neuroepithelial stem cell marker that is expressed in some types of tumor cells. | 25839093 |
| leukemia | Stem Cell Exhaustion | Age and Modified European LeukemiaNet Classification to Predict Transplant Outcomes: An Integrated Approach for Acute Myelogenous Leukemia Patients Undergoing Allogeneic Stem Cell Transplantation. | 25840338 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We evaluated the prognostic significance of a modified European LeukemiaNet (ELN) classification for patients with acute myelogenous leukemia (AML) undergoing hematopoietic stem cell transplantation (HSCT) while in first complete remission (CR1). | 25840338 |
| Hyperimmunoglobulin M syndrome | Stem Cell Exhaustion | The long-term outcome of X-linked hyper-IgM syndrome (XHIM) caused by mutations in CD40LG is poor, and the only curative treatment is hematopoietic stem cell transplantation (HSCT). | 25840720 |
| Primary amyloidosis | Stem Cell Exhaustion | Outcome of Patients with Immunoglobulin Light-Chain Amyloidosis with Lung, Liver, Gastrointestinal, Neurologic, and Soft Tissue Involvement after Autologous Hematopoietic Stem Cell Transplantation. | 25842049 |
| Hepatitis B | Stem Cell Exhaustion | Reactivation of hepatitis B virus (HBV) following immunosuppressive therapy or hematopoietic stem cell transplantation is a potentially fatal complication that may occur even in patients with prior resolution of HBV infection. | 25842192 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Cytogenetic patterns of relapse following allogeneic stem cell transplantation in morphologic complete remission in patients with acute myeloid leukemia. | 25843488 |
| Multiple Myeloma | Stem Cell Exhaustion | High-dose therapy and autologous stem cell transplantation (ASCT) have proven efficacy in patients with multiple myeloma responding well to induction therapy. | 25843652 |
| Graft-vs-Host Disease, Failure | Stem Cell Exhaustion | Severe and early onset of aGVHD, bone marrow as the stem cell source, and an HLA mismatch were associated with the failure to respond to GC in logistic regression. | 25843653 |
| Specialty Type - cancer | Stem Cell Exhaustion | Aldehyde dehydrogenase 1 (ALDH1), a cancer stem cell marker, has been reported to be altered in human carcinogenesis. | 25843691 |
| Acute Coronary Syndrome | Stem Cell Exhaustion | Ticagrelor increases endothelial progenitor cell level compared to clopidogrel in acute coronary syndromes: A prospective randomized study. | 25846661 |
| Esophageal | Stem Cell Exhaustion | Recent studies have suggested that oesophageal submucosal gland (ESMG) ducts harbour progenitor cells that may contribute to oesophageal metaplasia. | 25847432 |
| Ki-1+ Anaplastic Large Cell Lymphoma, Toxic effect | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is also an effective treatment for relapsed ALCL, although transplant-related toxicity is a problem. | 25847601 |
| Richters syndrome", Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Allogeneic stem-cell transplantation (SCT) induces long-term remission in a fraction of patients with high-risk chronic lymphocytic leukemia (CLL) or Richter's transformation (RT). | 25847930 |
| Dry Eye Syndromes | Stem Cell Exhaustion | Prospective Randomized Trial Comparing Efficacy of Topical Loteprednol Etabonate 0.5% Versus Cyclosporine-A 0.05% for Treatment of Dry Eye Syndrome Following Hematopoietic Stem Cell Transplantation. | 25850708 |
| Dry Eye Syndromes | Stem Cell Exhaustion | To evaluate the safety and efficacy of topical loteprednol etabonate (LE) 0.5% compared with cyclosporine A (CsA) 0.05% for the prophylaxis and treatment of dry eye syndrome (DES) after hematopoietic stem cell transplantation (HSCT). | 25850708 |
| Neoplasms | Stem Cell Exhaustion | Hematopoietic progenitor cells collection in pediatric patients with brain tumor. | 25851934 |
| Brain Neoplasms | Stem Cell Exhaustion | To analyze the efficacy and safety of hematopoietic progenitor cells (HPC) collections by leukapheresis in pediatric patients with brain tumors. | 25851934 |
| Fever | Stem Cell Exhaustion | Long-lasting stem cell-like memory CD8+ T cells with a naive-like profile upon yellow fever vaccination. | 25855494 |
| Inflammation, Fibrosis Assessment | Stem Cell Exhaustion | The goal of this study was to test the hypothesis that bone marrow stem cells (CD34+) will improve histological measurements of vascularity, fibrosis, and inflammation in human subjects undergoing left ventricular assist device (LVAD) placement as a bridge to cardiac transplantation. | 25857908 |
| Amyloidosis | Stem Cell Exhaustion | Induction Therapy with Bortezomib Followed by Bortezomib-High Dose Melphalan and Stem Cell Transplantation for Light Chain Amyloidosis: Results of a Prospective Clinical Trial. | 25858810 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells (CSCs) have been reported to play important roles in multiple cancer types. | 25862862 |
| leukemia | Stem Cell Exhaustion | Leukemia cell mobilization with G-CSF plus plerixafor during busulfan-fludarabine conditioning for allogeneic stem cell transplantation. | 25867648 |
| Neoplasms | Stem Cell Exhaustion | We hypothesized that during conditioning chemotherapy for allogeneic stem cell transplant (allo-SCT), the disruption of stromal-leukemia interactions using G-CSF in combination with the CXCR4-specific inhibitor, plerixafor, may promote the release of leukemic cells from the niche and increase tumor elimination. | 25867648 |
| Leukoencephalopathy, Progressive Multifocal, Leukoencephalopathy | Stem Cell Exhaustion | Extended application of allogeneic stem cell transplantation (alloSCT) is expected to increase the frequency of JC polyomavirus (JCPyV)-related progressive multifocal leukoencephalopathy (PML). | 25867649 |
| Multiple Myeloma | Stem Cell Exhaustion | Autologous stem cell transplantation versus novel drugs or conventional chemotherapy for patients with relapsed multiple myeloma after previous ASCT. | 25867654 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | High-dose therapy (HDT) followed by autologous stem cell transplantation (ASCT) is the most common first-line treatment for patients with multiple myeloma (MM) under 65 years of age. | 25867654 |
| Heart Diseases | Stem Cell Exhaustion | Transplantation of cardiac stem cells (CSCs) may be one of the best strategies to cure adult or pediatric heart diseases. | 25867933 |
| Aggressive Non-Hodgkin Lymphoma | Stem Cell Exhaustion | The NCIC CTG LY.12 study showed that gemcitabine, dexamethasone, and cisplatin (GDP) were noninferior to dexamethasone, cytarabine, and cisplatin (DHAP) in patients with relapsed or refractory aggressive histology lymphoma prior to autologous stem cell transplantation. | 25868579 |
| Post-Treatment Lyme Disease Syndrome, Post-transplant lymphoproliferative disorder | Stem Cell Exhaustion | Posttransplantation lymphoproliferative disorders (PTLDs) are life-threatening complications after solid organ and hematopoietic stem cell transplantation. | 25868706 |
| Hemolytic crisis | Stem Cell Exhaustion | Eculizumab dramatically relieved the signs and symptoms and then he safely underwent unrelated bone marrow transplantation, suggesting the feasibility and effectiveness of eculizumab before stem cell transplantation in children with PNH/AA in hemolytic crisis. | 25868955 |
| methyldopa | Stem Cell Exhaustion | Pluripotent stem cell-derived retinal pigment epithelial (RPE) cells are currently being tested for cell replacement in late-stage age-related macular degeneration (AMD). | 25869002 |
| methyldopa | Stem Cell Exhaustion | Here, we demonstrate that transplantation of neural progenitor cells (NPCs) derived from induced pluripotent stem cells (iNPCs) limits disease progression in the Royal College of Surgeons rat, a preclinical model of AMD. | 25869002 |
| Hematologic Neoplasms, Mortality, Premature | Stem Cell Exhaustion | Productivity loss due to premature mortality caused by blood cancer: a study based on patients undergoing stem cell transplantation. | 25869153 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Stem cell transplantation has been used for many years to treat haematological malignancies that could not be cured by other treatments. | 25869153 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Our purpose was to evaluate labour productivity losses associated with premature mortality due to blood cancer in recipients of stem cell transplantations. | 25869153 |
| Hematologic Neoplasms | Stem Cell Exhaustion | We collected primary data from the clinical histories of blood cancer patients who had undergone stem cell transplantation between 2006 and 2011 in two Spanish hospitals. | 25869153 |
| Chronic Obstructive Airway Disease, Pulmonary arterial hypertension | Stem Cell Exhaustion | Influence of Rho kinase inhibitor fasudil on late endothelial progenitor cells in peripheral blood of COPD patients with pulmonary artery hypertension. | 25869561 |
| Chronic Obstructive Airway Disease, Lung Diseases, Obstructive, Pulmonary arterial hypertension | Stem Cell Exhaustion | To investigate the influence of Fasudil, a Rho inhibitor on the number and functions of the late endothelial progenitor cells in peripheral blood of chronic obstructive pulmonary diseases (COPD) patients with pulmonary artery hypertension. | 25869561 |
| Chronic Obstructive Airway Disease, Pulmonary arterial hypertension | Stem Cell Exhaustion | The Rho-kinase inhibitor Fasudil increased the number and enhanced the function of the late endothelial progenitor cells in peripheral blood of COPD patients with pulmonary artery hypertension (Tab. | 25869561 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Autologous Stem-Cell Transplantation Without Hematopoietic Support for the Treatment of Hematologic Malignancies in Jehovah's Witnesses. | 25870085 |
| Lymphoma, Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Autologous stem-cell transplantation (ASCT) has shown to provide curative benefit in patients with relapsed lymphoma and multiple myeloma (MM), often requiring hematopoietic support until marrow engraftment. | 25870085 |
| Fungemia, Neoplasms | Stem Cell Exhaustion | Fungemia occurred in 333 (0.23%; 95% confidence interval [CI], .21-.26) patients, ranging from 0.15% in patients with solid tumors to 1.55% in hematopoietic stem cell transplantation recipients. | 25870323 |
| Infection | Stem Cell Exhaustion | Life-threatening Streptococcus pneumoniae infections often occur after hematopoietic stem cell transplant (HSCT); vaccination is important for prevention. | 25870329 |
| Malignant neoplasm of lung | Stem Cell Exhaustion | IL-8 confers resistance to EGFR inhibitors by inducing stem cell properties in lung cancer. | 25871388 |
| Diabetes, Diabetic Foot | Stem Cell Exhaustion | Circulating endothelial progenitor cells and angiogenic factors in diabetes complicated diabetic foot and without foot complications. | 25872462 |
| Neoplasms, Hepatitis, Specialty Type - cancer | Stem Cell Exhaustion | Active specific immunotherapy (ASI) with autologous dendritic cells (DC) presenting antigens from autologous tumor stem cell (TC) lines is associated with promising long-term survival in metastatic cancer, but hepatitis patients were excluded. | 25873455 |
| Liver carcinoma, Hepatitis, Neoplasms | Stem Cell Exhaustion | Phase I trial of active specific immunotherapy with autologous dendritic cells pulsed with autologous irradiated tumor stem cells in hepatitis B-positive patients with hepatocellular carcinoma. | 25873455 |
| Ischemic stroke | Stem Cell Exhaustion | Circulating endothelial progenitor cells and the risk of vascular events after ischemic stroke. | 25874380 |
| Electrocardiogram: myocardial infarction (finding), Microalbuminuria, In-Stent Restenosis Indicator | Stem Cell Exhaustion | Association between microalbuminuria predicting in-stent restenosis after myocardial infarction and cellular senescence of endothelial progenitor cells. | 25874702 |
| Microalbuminuria, Acute myocardial infarction | Stem Cell Exhaustion | We investigated the role of microalbuminuria to the function of endothelial progenitor cells (EPCs), that might affect to outcome of acute myocardial infarction (AMI) patients. | 25874702 |
| Inflammation, Hyperplasia | Stem Cell Exhaustion | This chronic inflammation results in the repression of gut local immune response, which in turn leads to the over-proliferation and mis-differentiation of the intestinal stem cells, thereby resulting in gut hyperplasia. | 25875575 |
| HD Term Type | Stem Cell Exhaustion | Importantly, RTP801 protein levels were elevated in both neural telencephalic progenitors differentiated from HD patient-derived induced pluripotent stem cells and in the putamen and cerebellum of human HD postmortem brains. | 25876513 |
| Specialty Type - cancer | Stem Cell Exhaustion | It is thought that stem cells have the potential to be induced into a cancer stem cell phenotype and that these may play an important role in resistance to radiotherapy. | 25877536 |
| Neoplasms | Stem Cell Exhaustion | Several models of radiation have predicted that stem cells play an important role in tumour initiation and that bystander responses could play a role in proliferation and self-renewal. | 25877536 |
| Multiple Myeloma, melphalan/prednisone protocol | Stem Cell Exhaustion | Patients with untreated or relapsed multiple myeloma not eligible for high-dose chemotherapy followed by autologous stem cell transplantation and who were scheduled for bortezomib mono- or combination therapy or melphalan-prednisone (MP) alone were included in this study. | 25877940 |
| Polyneuropathy | Stem Cell Exhaustion | Polyneuropathy improvement following autologous stem cell transplantation for POEMS syndrome. | 25878176 |
| POEMS Syndrome, Endocrine System Diseases, Neuropathy, Polyneuropathy, Organomegaly | Stem Cell Exhaustion | To study the evolution of the neuropathy and long-term disability in a large cohort of patients with POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) syndrome following autologous stem cell transplantation (ASCT). | 25878176 |
| Specialty Type - cancer | Stem Cell Exhaustion | The cancer-associated fibroblast (CAF), one of the most important cellular components in the cancer stroma, might contribute to the progression of the disease due to its plasticity, a behavior of the stem cells. | 25879842 |
| Secondary Neoplasm, Hepatocarcinogenesis | Stem Cell Exhaustion | Our data provides evidence of the plasticity of the CAF and the NTF as stem cells in the process of hepatocarcinogenesis and metastasis. | 25879842 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Single cell sorting and culture were performed in the various sets of hematopoietic stem cells including CD34+CD38- acute myeloid leukemia (AML) cell population (ASCs) from a total of 60 patients with AML, and 11 healthy controls. | 25881148 |
| Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | The Leucine rich repeat containing G protein coupled receptor 5 (LGR5), may be a candidate marker of non-small cell lung cancer (NSCLC) cells with stem cell-like properties. | 25881507 |
| Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | Aldehyde dehydrogenase 1A1 (ALDH1A1) is one of NSCLC stem cell markers. | 25881507 |
| Non-Small Cell Lung Carcinoma, Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | The expression of LGR5 and ALDH1A1 were closely associated with the tumorigenicity, metastasis and poor prognosis of NSCLC, and LGR5+ cells in NSCLC were likely to be the cancer cells with stem cell-like properties due to the significant correlation between LGR5 and ALDH1A1. | 25881507 |
| Acute leukemia | Stem Cell Exhaustion | Comparison of outcomes after unrelated cord blood and unmanipulated haploidentical stem cell transplantation in adults with acute leukemia. | 25882700 |
| Acute leukemia | Stem Cell Exhaustion | Outcomes after unmanipulated haploidentical stem cell transplantation (Haplo) and after unrelated cord blood transplantation (UCBT) are encouraging and have become alternative options to treat patients with high-risk acute leukemia without human leukocyte antigen (HLA) matched donor. | 25882700 |
| Heart failure | Stem Cell Exhaustion | Human cardiac progenitor cells (hCPC) improve heart function after autologous transfer in heart failure patients. | 25882843 |
| Colorectal Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Still, this picture might be more complex since chemotherapy by itself might alter MDR activity, and furthermore, today limited data is available about MDR activity of cancer stem cells in colorectal cancers. | 25885226 |
| Spinal Cord Injuries | Stem Cell Exhaustion | Chronic spinal cord injury treated with transplanted autologous bone marrow-derived mesenchymal stem cells tracked by magnetic resonance imaging: a case report. | 25885347 |
| Cervical spinal cord structure | Stem Cell Exhaustion | Intrathecal transplantation is a minimally invasive method for the delivery of stem cells, however, whether the cells migrate from the lumbar to the injured cervical spinal cord has not been proved in humans. | 25885347 |
| Cervical spinal cord injury | Stem Cell Exhaustion | We describe an attempt to track bone marrow-derived mesenchymal stem cells in a patient with a chronic cervical spinal cord injury. | 25885347 |
| Subluxation of atlantoaxial joint, Spinal Cord Injuries | Stem Cell Exhaustion | A 33-year-old Thai man who sustained an incomplete spinal cord injury from the atlanto-axial subluxation was enrolled into a pilot study aiming to track bone marrow-derived mesenchymal stem cells, labeled with superparamagnetic iron oxide nanoparticles, from intrathecal transplantation in chronic cervical spinal cord injury. | 25885347 |
| Cervical spinal cord structure | Stem Cell Exhaustion | Intrathecal injection of bone marrow-derived stem cells at the lumbar spine level could deliver the cells to the injured cervical spinal cord. | 25885347 |
| Immunocompromised Host | Stem Cell Exhaustion | However, its clinical manifestations are almost exclusively seen in immunocompromised patients, particularly in kidney and hematopoietic stem cell transplantation recipients. | 25886491 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | A 15-y-old female suffering from common B-cell acute lymphoblastic leukaemia underwent hematopoietic stem cell transplantation. | 25886491 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Factors influencing life satisfaction in acute myeloid leukemia survivors following allogeneic stem cell transplantation: a cross-sectional study. | 25888906 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Allogeneic stem cell transplantation (alloSCT) is the preferred option of postremission therapy for high-risk patients suffering from acute myeloid leukemia (AML). | 25888906 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cells (CSCs) are defined with the ability to be self-renewal and potentially promote proliferation and formation of tumors. | 25889325 |
| Antilymphocyte Serum | Stem Cell Exhaustion | Human neural stem cell transplantation in ALS: initial results from a phase I trial. | 25889343 |
| Cessation of life | Stem Cell Exhaustion | We transplanted GMP-grade, fetal human neural stem cells from natural in utero death (hNSCs) into the anterior horns of the spinal cord to test for the safety of both cells and neurosurgical procedures in these patients. | 25889343 |
| Chronic Kidney Diseases | Stem Cell Exhaustion | SIRT1 activation rescues doxorubicin-induced loss of functional competence of human cardiac progenitor cells. | 25889431 |
| Heart failure | Stem Cell Exhaustion | To determine whether SIRT1 activator, resveratrol (RES), interferes with adverse effects of DOXO on cardiac progenitor cells (CPCs): 1) human CPCs (hCPCs) were exposed in vitro to DOXO or DOXO+RES and their regenerative potential was tested in vivo in an animal model of DOXO-induced heart failure; 2) the in vivo effects of DOXO+RES co-treatment on CPCs were studied in a rat model. | 25889431 |
| Specialty Type - cancer | Stem Cell Exhaustion | Pharmacological intervention at the level of tissue-specific progenitor cells may provide cardiac benefits for the growing population of long-term cancer survivors that are at risk of chemotherapy-induced cardiovascular toxicity. | 25889431 |
| Aniridia, Burn injury, Conjunctivitis | Stem Cell Exhaustion | Sixteen eyes of 16 patients who had total (n=14) and partial (n=2) limbal stem cell deficiency (chemical burns, five eyes; iatrogenic causes, four eyes; aniridia, three eyes; trachoma-induced, two eyes; contact lens over-wear, one eye; and cicatrising conjunctivitis, one eye) and who had failed prior therapy were recruited prospectively into the study. | 25889475 |
| Multiple Myeloma | Stem Cell Exhaustion | Predicting poor peripheral blood stem cell collection in patients with multiple myeloma receiving pre-transplant induction therapy with novel agents and mobilized with cyclophosphamide plus granulocyte-colony stimulating factor: results from a Gruppo Italiano Malattie EMatologiche dell'Adulto Multiple Myeloma Working Party study. | 25889496 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | A still not well defined proportion of patients with multiple myeloma (MM) and eligible for autologous stem cell transplantation (AuSCT) fails to mobilize CD34+ peripheral blood stem cells (PBSC) at all or to collect an adequate number for a safe procedure or sufficient for multiple transplants. | 25889496 |
| Liver Failure, Acute | Stem Cell Exhaustion | Compared with human primary fetal liver cells, human hepatic stem cell transplantation rescued Alb-TRECK/SCID mice with lethal fulminant hepatic failure, and human hepatic stem cell-derived humanized livers secreted more human albumin into mouse sera and also functioned as a "human liver" that could metabolize the drugs ketoprofen and debrisoquine. | 25889844 |
| protein reconstitution, Liver Failure, Acute | Stem Cell Exhaustion | Human hepatic stem cells transplanted into a fulminant hepatic failure Alb-TRECK/SCID mouse model exhibit liver reconstitution and drug metabolism capabilities. | 25889844 |
| Diphtheria Toxin, Liver Failure, Acute | Stem Cell Exhaustion | Both human primary fetal liver cells and hepatic stem cells were successfully repopulated in the livers of Alb-TRECK/SCID mice that developed lethal fulminant hepatic failure after administering diphtheria toxin; the repopulation rate in some mice was nearly 100%. | 25889844 |
| B-Cell Lymphomas | Stem Cell Exhaustion | CD34+ selected versus unselected autologous stem cell transplantation in patients with advanced-stage mantle cell and diffuse large B-cell lymphoma. | 25890431 |
| Medial collateral ligament, Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | High-dose chemotherapy (HDCT) with autologous stem cell transplantation (ASCT) has improved progression-free (PFS) and overall survival (OS) in MCL and relapsed DLBCL. | 25890431 |
| Neurotoxicity Syndromes, Multiple Myeloma | Stem Cell Exhaustion | Neurotoxicity of stem cell mobilization chemotherapy with vinorelbine in myeloma patients after bortezomib treatment. | 25891070 |
| Polyneuropathy, Multiple Myeloma | Stem Cell Exhaustion | Our data indicate that a single administration of vinorelbine to mobilize autologous stem cells is associated with significant additional polyneuropathy in bortezomib pretreated myeloma patients. | 25891070 |
| Specialty Type - cancer, Cholangiocarcinoma | Stem Cell Exhaustion | Profiles of cancer stem cell subpopulations in cholangiocarcinomas. | 25892683 |
| Specialty Type - cancer, Congenital contractural arachnodactyly | Stem Cell Exhaustion | We characterized cancer stem cells (CSCs) in CCA subtypes and evaluated their cancerogenic potential. | 25892683 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Allogeneic Hematopoietic Stem Cell Transplantation in Mantle Cell Lymphoma: A Retrospective Analysis of 7 Patients. | 25895548 |
| Juvenile Myelomonocytic Leukemia | Stem Cell Exhaustion | Notably, unlike most JMML cases, Patient 2 did not require steroids or hematopoietic stem cell transplantation. | 25896945 |
| Hepatic Veno-Occlusive Disease, Lymphoma | Stem Cell Exhaustion | High pre-transplant serum ferritin and busulfan-thiotepa conditioning regimen as risk factors for hepatic sinusoidal obstructive syndrome after autologous stem cell transplantation in patients with malignant lymphoma. | 25899401 |
| Hepatic Veno-Occlusive Disease, Spondylo-ocular syndrome, Lymphoma | Stem Cell Exhaustion | Few studies have evaluated the risk factors for hepatic sinusoidal obstructive syndrome (SOS) in patients with malignant lymphoma receiving autologous stem cell transplantation (ASCT). | 25899401 |
| Nasal Type Extranodal NK/T-Cell Lymphoma | Stem Cell Exhaustion | High-dose therapy and autologous stem cell transplantation for extra-nodal NK/T lymphoma in patients from the Western hemisphere: a study from the European Society for Blood and Marrow Transplantation. | 25899403 |
| Primary Myelofibrosis | Stem Cell Exhaustion | Safety and outcome of allogeneic stem cell transplantation in myelofibrosis. | 25899468 |
| Lymphoma | Stem Cell Exhaustion | Prognostic factors of lymphoma patients after autologous stem cell transplantation. | 25903985 |
| Lymphoma | Stem Cell Exhaustion | BacKGROUND: Hematopoietic stem cell transplantation (HSCT) is considered to be a cure for lymphoma. | 25903985 |
| Malignant Head and Neck Neoplasm | Stem Cell Exhaustion | We confirmed the dysregulation of these noncoding RNAs in head and neck cancer cell lines derived from different anatomic sites, and determined that ectopic expression of the two lncRNAs inhibited key EMT and stem cell genes and reduced cellular proliferation and migration. | 25904139 |
| Thrombocytosis, Chronic myeloproliferative disorder, Polycythemia Vera, Primary Myelofibrosis | Stem Cell Exhaustion | Chronic myeloproliferative disorders such as polycythemia vera (PV), essential thrombocytosis (ET), and idiopathic myelofibrosis arise from clonal proliferation of neoplastic stem cells in the bone marrow. | 25906101 |
| Fungal Colonization, Infection, Communicable Diseases, Hematologic Neoplasms | Stem Cell Exhaustion | Fungal colonization and infections remain a major cause of infection morbidity and mortality following hematopoietic stem cell transplantation (HSCT) in patients with hematological malignancies. | 25907308 |
| Trial Disease Assessments Domain | Stem Cell Exhaustion | We studied hemostasis changes using thromboelastography (TEG), thrombin generation test (TGT) and thrombodynamics (TD) in primary MM patients (PMMpt, n=25) and patients in remission (RMMpt, n=34) during blood stem cell (BSC) mobilization. | 25907422 |
| Phaeohyphomycosis | Stem Cell Exhaustion | Fifty-six patients with phaeohyphomycosis were identified from 15 centers, comprising 26 stem cell transplant (SCT) and 30 solid organ transplant (SOT) recipients. | 25908651 |
| Toxic effect | Stem Cell Exhaustion | In summary, this combination is effective in untreated patients, with an acceptable toxicity profile, but given the introduction of second-generation novel agents and monoclonal antibodies, the combination will probably be better reserved for relapsing patients, in whom stem cell collection is not needed, while cost-effective combinations with non-cross-resistant drugs continue to represent a medical need. | 25911554 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Because the indication of allograft (allogeneic stem cell transplantation [alloSCT]) for multiple myeloma (MM) has widened in recent years, thanks to the development of reduced-intensity conditionings (RIC), it is still unclear if myeloablative conditioning (MAC) remains appropriate. | 25911579 |
| Complement Membrane Attack Complex | Stem Cell Exhaustion | RIC and MAC populations were different regarding age (53.5 versus 47.1 years, respectively), number of prior autologous (auto)SCTs (93.2% versus 79.6% had at least 2 autoSCTs), and stem cell source (90.2% versus 61.2% received peripheral blood). | 25911579 |
| Chronic graft-versus-host disease, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Mild chronic graft-versus-host disease may alleviate poor prognosis associated with FLT3 internal tandem duplication for adult acute myeloid leukemia following allogeneic stem cell transplantation with myeloablative conditioning in first complete remission: a retrospective study. | 25912052 |
| FLT3 Internal Tandem Duplication, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The significance of FLT3-ITD at diagnosis was retrospectively estimated for allo-HSCT (allogeneic hematopoietic stem cell transplantation) outcomes in 140 patients, median age of 38, undergoing allo-HSCT after myeloablative conditioning in first complete remission of AML. | 25912052 |
| Infection of bloodstream | Stem Cell Exhaustion | The Changing Epidemiology of Bloodstream Infections and Resistance in Hematopoietic Stem Cell Transplantation Recipients. | 25912636 |
| Behavioral Symptoms Index Composite Score (BASC-2), Infection of bloodstream | Stem Cell Exhaustion | Patients receiving hematopoietic stem cell transplantation (HSCT) are exposed to highly immunosuppressive conditions and bloodstream infections (BSIs) are one of the most common major complications within this period. | 25912636 |
| Atherosclerosis | Stem Cell Exhaustion | Effects of olmesartan on endothelial progenitor cell mobilization and function in carotid atherosclerosis. | 25913171 |
| Atherosclerosis | Stem Cell Exhaustion | Our study aimed to explore the effects and mechanism of olmesartan on endothelial progenitor cell mobilization and function in carotid atherosclerosis. | 25913171 |
| Atherosclerosis | Stem Cell Exhaustion | However, its role in the function of endothelial progenitor cells in atherosclerosis patients is still unclear. | 25913171 |
| Carotid Atherosclerosis | Stem Cell Exhaustion | Olmesartan can effectively promote the endothelial progenitor cells mobilization and improve their function in patients with carotid atherosclerosis, independent of basic characteristics. | 25913171 |
| Neuromyelitis Optica | Stem Cell Exhaustion | Resolution of aquaporin-4 antibodies in a woman with neuromyelitis optica treated with human autologous stem cell transplant. | 25913278 |
| N-nitrosomorpholine, Neuromyelitis Optica | Stem Cell Exhaustion | We report a 47-year-old woman with highly active neuromyelitis optica (NMO) and persistent high titre anti-aquaporin-4 antibodies (anti-AQP-4) who was resistant to multiple immune therapies until she underwent autologous hematopoietic stem cell transplant (auto-HSCT). | 25913278 |
| Osteogenesis | Stem Cell Exhaustion | Mesenchymal stem cells (MSCs) isolated from spinal ligaments with ectopic ossification have a propensity toward the osteogenic lineage. | 25913759 |
| Autoimmune Diseases, Lupus Erythematosus, Encephalitis, St. Louis | Stem Cell Exhaustion | Autologous hematopoietic stem cell (HSC) and mesenchymal stem cell (MSC) transplantation is currently being evaluated as a novel treatment for autoimmune diseases, such as systemic lupus erythematosus (SLE). | 25914407 |
| Lupus Erythematosus, Lupus Nephritis, White blood cell count decreased | Stem Cell Exhaustion | Combined transplantation of autologous hematopoietic stem cells and allogenic mesenchymal stem cells increases T regulatory cells in systemic lupus erythematosus with refractory lupus nephritis and leukopenia. | 25914407 |
| leukemia | Stem Cell Exhaustion | Conventional strategies are not particularly successful in the treatment of leukaemia, and identification of signalling pathways crucial to the activity of leukaemia stem cells will provide targets for the development of new therapies. | 25915125 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The LAIR1-SHP-1-CAMK1-CREB pathway sustains the survival and self-renewal of AML stem cells. | 25915125 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | In a variety of tumors, cancer cells with stem cell-like properties seem to form the basis of tumor initiation because of their ability to self-renew and proliferate. | 25916394 |
| Malignant Neoplasms | Stem Cell Exhaustion | Further studies are required to validate whether some stem cell-associated markers, such as SOX2, could serve as targets for therapeutic approaches and whether NGFR expression could be utilized as a predictor of malignancy. | 25916394 |
| Retinal Pigments | Stem Cell Exhaustion | Comparative study between amniotic-fluid mesenchymal stem cells and retinal pigmented epithelium (RPE) stem cells ability to differentiate towards RPE cells. | 25916690 |
| Blastic plasmacytoid dendritic cell neoplasm | Stem Cell Exhaustion | Long-term survival following autologous and allogeneic stem cell transplantation for blastic plasmacytoid dendritic cell neoplasm. | 25918345 |
| Blastic plasmacytoid dendritic cell neoplasm | Stem Cell Exhaustion | We sought to clarify the role of high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (auto-HSCT) and allogeneic hematopoietic stem cell transplantation (allo-HSCT) to treat blastic plasmacytoid dendritic cell neoplasm (BPDCN). | 25918345 |
| Rheumatoid Arthritis | Stem Cell Exhaustion | Mesenchymal stem cells from patients with rheumatoid arthritis display impaired function in inhibiting Th17 cells. | 25918734 |
| Immune System Diseases | Stem Cell Exhaustion | Mesenchymal stem cells (MSCs) possess multipotent and immunomodulatory properties and are suggested to be involved in the pathogenesis of immune-related diseases. | 25918734 |
| Pituitary Neoplasms, Neoplasms | Stem Cell Exhaustion | Pituitary tumors contain a side population with tumor stem cell-associated characteristics. | 25921430 |
| Adenoma | Stem Cell Exhaustion | The human adenoma pSP also showed upregulated expression of the pituitary stem cell marker SOX2. | 25921430 |
| Pituitary Neoplasms, Neoplasms | Stem Cell Exhaustion | In the present study, we searched for a side population (SP) in pituitary tumors representing cells with high efflux capacity and potentially enriched for tumor stem cells (TSCs). | 25921430 |
| Peripheral Arterial Diseases | Stem Cell Exhaustion | Therapeutic Efficacy of Stem Cell-based Therapy in Peripheral Arterial Disease: A Meta-Analysis. | 25923119 |
| Ulcer | Stem Cell Exhaustion | After synthesizing data, the meta-analysis showed significant improvement in the amputation rate (OR=0.33, 95%CI=0.22-0.51; P<0.001), ulcer healing (OR=6.11, 95%CI=3.04-12.28; P<0.001), and ABI (SMD=0.65, 95%CI=0.33-0.97; P<0.001) for the stem cell-based therapy group compared with the controls. | 25923119 |
| Ulcer | Stem Cell Exhaustion | Moreover, significant improvement in the amputation rate, ulcer healing, and ABI were also found based on the time point and stem cell source. | 25923119 |
| altretamine/cisplatin/cyclophosphamide protocol | Stem Cell Exhaustion | Long-term, regular RIPre improved endothelial function in patients with CHD, possibly due to STAT-3 activation, and this may have led to an increase in endothelial progenitor cells. | 25923462 |
| Scleroderma | Stem Cell Exhaustion | Successful autologous hematopoietic stem cell transplantation for a patient with rapidly progressive localized scleroderma. | 25923607 |
| Scleroderma | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplant (HSCT) for rapidly progressive disease has not been reported in localized scleroderma. | 25923607 |
| Infection | Stem Cell Exhaustion | Six patients were recipients of allogeneic hematopoietic stem cell transplant, with their infections caused by five Legionella species. | 25926494 |
| Specialty Type - cancer | Stem Cell Exhaustion | Epithelial-mesenchymal transition (EMT) is involved in important malignant features of cancer cells, like invasion, metastatic potential, anti-apoptotic and stem-cell like phenotypes. | 25928859 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Most patients had underlying hematologic malignancies (54 %), and 7 % were recipients of hematopoietic stem cell transplantation. | 25929421 |
| Enterovirus Gastroenteritis | Stem Cell Exhaustion | Characteristics and outcomes of patients diagnosed with norovirus gastroenteritis after allogeneic hematopoietic stem cell transplantation based on immunochromatography. | 25930664 |
| Enterovirus Gastroenteritis | Stem Cell Exhaustion | Norovirus gastroenteritis (NV-GE) is a highly transmittable disease that can lead to fatal outcomes in vulnerable populations including patients after hematopoietic stem cell transplantation (HSCT). | 25930664 |
| Werner Syndrome | Stem Cell Exhaustion | A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. | 25931448 |
| ELN wt Allele | Stem Cell Exhaustion | Here, we report on the generation of a human WS model in human embryonic stem cells (ESCs). | 25931448 |
| Injury of gastrointestinal tract | Stem Cell Exhaustion | HGF Gene Modification in Mesenchymal Stem Cells Reduces Radiation-Induced Intestinal Injury by Modulating Immunity. | 25933295 |
| Amyotrophic Lateral Sclerosis, Antilymphocyte Serum | Stem Cell Exhaustion | Stem cell therapy is an emerging alternative therapeutic or disease-modifying strategy for amyotrophic lateral sclerosis (ALS). | 25934946 |
| Age related macular degeneration, Macular degeneration | Stem Cell Exhaustion | Here, we report the safety and tolerability of subretinal transplantation of human embryonic-stem-cell (hESC)-derived retinal pigment epithelium in four Asian patients: two with dry age-related macular degeneration and two with Stargardt macular dystrophy. | 25937371 |
| Lymphoma | Stem Cell Exhaustion | BV before high-dose chemotherapy-ASCT did not adversely affect peripheral blood stem cell mobilization and subsequent engraftment in a cohort of heavily pretreated patients with CD30(+) lymphomas. | 25937397 |
| Lymphoma | Stem Cell Exhaustion | Hematopoietic Progenitor Cell Harvesting Is Feasible after Treatment with Brentuximab Vedotin in CD30(+) Lymphoma Patients Who Received Multiple Prior Lines of Treatment. | 25937397 |
| leukemia | Stem Cell Exhaustion | Health-Related Quality of Life in leukemia Survivors of Allogeneic Hematopoietic Stem Cell Transplantation Employing the Mexican Reduced-Intensity Conditioning. | 25938844 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | High graft CD3 stem cell dose was associated with a trend of lower rate of subsequent CMV infection (HR = 0.543, P = 0.056). | 25940504 |
| Lupus Vulgaris | Stem Cell Exhaustion | Transplantation of Adipose Tissue-Derived Mesenchymal Stem Cells Prevents the Development of Lupus Dermatitis. | 25941899 |
| Periodontal Route of Administration | Stem Cell Exhaustion | Recent animal studies have demonstrated histologically that bone marrow- derived mesenchymal stem cells (MSCs) may enhance the regeneration of periodontal defects in dogs by differentiating MSCs into cementoblasts, osteoblasts and periodontal fibroblasts. | 25942341 |
| Gain | Stem Cell Exhaustion | Stem cells in combination with bioresorbable PLA/PGA membrane was effective for root coverage resulted in a significant reduction in gingival recession, greater gain in CAL and WKG. | 25942341 |
| diabetic | Stem Cell Exhaustion | Circulating Progenitor Cell Count Predicts Microvascular Outcomes in Type 2 Diabetic Patients. | 25942480 |
| Diabetes | Stem Cell Exhaustion | Diabetes reduces the levels of circulating progenitor cells (CPCs) and endothelial progenitor cells (EPCs), which promote vascular repair and are inversely correlated with cardiovascular risk. | 25942480 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Levels of circulating (endothelial) progenitor cells predict microvascular outcomes in T2D. | 25942480 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | To assess its effectiveness, we compared overall survival (OS) between azacitidine and conventional treatment (CCT) in high-risk MDS patients, excluding those undergoing stem cell transplantation, submitted to the Spanish MDS registry from 2000 to 2013. | 25943181 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | AML patients undergoing IC without stem-cell transplant at two tertiary care centers were enrolled in a prospective, longitudinal study. | 25944029 |
| Virus Reactivation | Stem Cell Exhaustion | Large-scale multiplex polymerase chain reaction assay for diagnosis of viral reactivations after allogeneic hematopoietic stem cell transplantation. | 25946433 |
| Virus Reactivation | Stem Cell Exhaustion | Viral reactivations following hematopoietic stem cell transplantation are thought to result from the breakdown of both cell-mediated and humoral immunity. | 25946433 |
| Virus Reactivation | Stem Cell Exhaustion | Multiplex PCR was useful for detecting many viral reactivations after hematopoietic stem cell transplantation, simultaneously. | 25946433 |
| Dry Eye Syndromes, Stable chronic Graft vs Host Disease, Specialty Type - cancer, Chronic graft-versus-host disease, Graft-vs-Host Disease | Stem Cell Exhaustion | To investigate the factors associated with the development of ocular graft-versus-host disease (oGVHD) dry eye syndrome (DES) in patients with chronic GVHD (cGVHD) after receiving allogenic haematopoietic stem cell transplantation (AHSCT) METHODS: A retrospective chart review of patients receiving AHSCT between 1998 and 2013 at the Bone Marrow Transplant Unit of the British Columbia Cancer Agency was carried out. | 25947556 |
| methyldopa | Stem Cell Exhaustion | In this work, a tissue-on-a-chip approach was developed through combining human induced pluripotent stem cells, Electric Cell-substrate Impedance Sensing (ECIS) and reproducible electrical wounding assays to model and quantitatively study AMD. | 25950942 |
| Leukemia, Myelocytic, Acute, Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | Our data thus suggest that, in the present case, the AML and DLBCL arose from a common progenitor cell, as indicated by the clonal abnormality t(3,4)(p25;q21), and that different immunoglobulin heavy chain gene rearrangements occurred during each course of clonal evolution. | 25953309 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer Stem Cells Sensitivity Assay (STELLA) in Patients with Advanced Lung and Colorectal Cancer: A Feasibility Study. | 25955492 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cells represent a population of immature tumor cells found in most solid tumors. | 25955492 |
| Specialty Type - cancer | Stem Cell Exhaustion | In this study, we investigated whether cancer stem cells isolation and in vitro sensitivity assay are feasible in a clinical setting. | 25955492 |
| Failure, Specialty Type - cancer, effusion | Stem Cell Exhaustion | Cancer stem cells were isolated from effusions or fresh cancer tissue of 23 patients who progressed after standard therapy failure. | 25955492 |
| Secondary malignant neoplasm of liver, Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells were extracted from liver metastases in 6 cases (25%), lung nodules in 2 (8%), lymph node metastases in 3 (12.5%) and pleural/peritoneal/pericardial effusion in 13 (54%). | 25955492 |
| Malignant neoplasm of lung, Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells were successfully isolated in 15 patients (63%), including 14 with lung cancer (93.3%). | 25955492 |
| Specialty Type - cancer | Stem Cell Exhaustion | The approach used for the STELLA trial allowed isolation of cancer stem cells in a consistent proportion of patients. | 25955492 |
| Carotid Artery Injuries | Stem Cell Exhaustion | Transplantation of cryopreserved human umbilical cord blood-derived endothelial progenitor cells induces recovery of carotid artery injury in nude rats. | 25956351 |
| Endothelial dysfunction | Stem Cell Exhaustion | Transplantation of endothelial progenitor cells (EPCs) restores endothelial function in patients with endothelial dysfunction and initial denudation. | 25956351 |
| Have Been Vomiting, Nausea | Stem Cell Exhaustion | Fosaprepitant for the prevention of nausea and vomiting in patients receiving BEAM or high-dose melphalan before autologous hematopoietic stem cell transplant. | 25956421 |
| Nausea, Vomiting | Stem Cell Exhaustion | To assess the impact of single-dose fosaprepitant on nausea and emesis after BEAM and high-dose melphalan conditioning regimens for autologous hematopoietic stem cell transplantation. | 25956421 |
| Richters syndrome", Prolymphocytic Leukemia | Stem Cell Exhaustion | The median age was 57 years and median follow-up 36 months; 17 patients had del 17p/p53mutation, 19 patients had fludarabine-refractory disease, 11 relapsed after autologous stem cell transplantation, 8 had diagnosis of prolymphocytic leukemia, 4 had Richter syndrome, and 8 underwent transplantation with progressive or refractory disease. | 25958294 |
| Arterial Stiffness | Stem Cell Exhaustion | Secondary outcomes were aerobic capacity, arterial stiffness, numbers of endothelial (EPCs) and osteogenic progenitor cells (OPCs), migratory function of circulatory angiogenic cells, and health-related quality of life. | 25960303 |
| Multiple Myeloma | Stem Cell Exhaustion | High-dose therapy and autologous stem cell transplant in older adults with multiple myeloma. | 25961765 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Randomized trials showing that high-dose therapy with autologous stem cell transplant (ASCT) improved the overall survival (OS) in multiple myeloma (MM) excluded patients over age 65. | 25961765 |
| Job Syndrome, Autosome | Stem Cell Exhaustion | Successful haploidentical donor hematopoietic stem cell transplant and restoration of STAT3 function in an adolescent with autosomal dominant hyper-IgE syndrome. | 25962528 |
| Multiple Myeloma | Stem Cell Exhaustion | We retrospectively analyzed our transplant database from July 2000 to June 2012 to identify myeloma patients who received autologous stem cell transplantation while dialysis-dependent. | 25963284 |
| Adult Glioblastoma | Stem Cell Exhaustion | mRNA expression levels of hypoxia-induced and stem cell-associated genes in human glioblastoma. | 25963717 |
| Neoplasms, Malignant Neoplasms | Stem Cell Exhaustion | The roles of hypoxia-induced and stem cell-associated genes in the development of malignancy and tumour progression are well known. | 25963717 |
| Adult Glioblastoma, Neoplasms | Stem Cell Exhaustion | However, there are a limited number of studies analysing the impact of mRNA expression levels of hypoxia-induced and stem cell-associated genes in the tissues of brain tumours and glioblastoma patients. | 25963717 |
| Neoplasms, Glioblastoma | Stem Cell Exhaustion | Our data revealed higher mRNA expression levels of hypoxia-induced and stem cell-associated genes in tumour tissue than levels in the tumour adjacent tissues in patients with glioblastoma multiforme. | 25963717 |
| Tumor Hypoxia | Stem Cell Exhaustion | Additionally, the results indicate the role of stem-cell-related genes in tumour hypoxia. | 25963717 |
| Decreased platelet count | Stem Cell Exhaustion | Identification of anti-thrombopoietin receptor antibody in prolonged thrombocytopenia after allogeneic hematopoietic stem cell transplantation treated successfully with eltrombopag. | 25964100 |
| Lymphoma, Follicular | Stem Cell Exhaustion | A 55-year-old female with stage IVA follicular lymphoma in third complete remission underwent allogeneic peripheral blood stem cell transplantation. | 25964100 |
| Decreased platelet count | Stem Cell Exhaustion | Anti-TPOR antibody may play an important role in some cases of prolonged thrombocytopenia after allogeneic hematopoietic stem cell transplantation with unknown etiology, and eltrombopag could be a novel therapeutic option for such cases. | 25964100 |
| leukemia | Stem Cell Exhaustion | The combination of APO866 with Pgp inhibitors resulted in a synergistic cytotoxic effect in leukemia cells, while sparing normal CD34(+) progenitor cells and peripheral blood mononuclear cells. | 25964294 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer cells are typically defined as infinitely proliferating, whereas normal cells (except stem cells) are considered as being programmed to become senescent. | 25964555 |
| Heart Failure, Systolic | Stem Cell Exhaustion | Clinical observation of umbilical cord mesenchymal stem cell treatment of severe systolic heart failure. | 25966065 |
| Chronic systolic heart failure | Stem Cell Exhaustion | The aim of this study was to evaluate the effectiveness of umbilical cord mesenchymal stem cells (MSCs) in the treatment of chronic systolic heart failure. | 25966065 |
| Specialty Type - cancer | Stem Cell Exhaustion | Relationships between parenting self-efficacy and distress in parents who have school-aged children and have been treated with hematopoietic stem cell transplant or have no cancer history. | 25967755 |
| Specialty Type - cancer | Stem Cell Exhaustion | This study sought to address this issue by comparing parents with cancer who had undergone hematopoietic stem cell transplantation (HSCT) to parents without cancer on measures of PSE and psychological distress. | 25967755 |
| Toxoplasmosis | Stem Cell Exhaustion | Atovaquone for Prophylaxis of Toxoplasmosis after Allogeneic Hematopoietic Stem Cell Transplantation. | 25968483 |
| Infection, Toxoplasmosis, Pneumocystis jiroveci | Stem Cell Exhaustion | Toxoplasmosis and infections by other opportunistic agents such as Pneumocystis jirovecii constitute life-threatening risks for patients after allogeneic hematopoietic stem cell transplantation. | 25968483 |
| Toxic effect | Stem Cell Exhaustion | We explored atovaquone as an alternative and compared it with TMP-SMX regarding toxicity and efficacy during the first 100 days after transplantation in 155 consecutive adult stem cell recipients. | 25968483 |
| Liver Cirrhosis | Stem Cell Exhaustion | Recently, stem cell transplantation has emerged as a promising treatment for cirrhosis. | 25970080 |
| Liver Cirrhosis, Hepatitis | Stem Cell Exhaustion | The aim of this study was to determine whether autologous peripheral blood stem cell transplantation can improve liver functional reserve in patients with hepatitis B-induced cirrhosis. | 25970080 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer gene aberrations were identified in all specimens and pathway-level analysis was applied to aggregate data, which identified stem cell pluripotency pathway enrichment and highlighted recurring, significant amplification of SOX2, PIK3CA, NTRK1, GNAS, CTNNB1, and FGFR1. | 25970776 |
| Multiple Myeloma | Stem Cell Exhaustion | We retrospectively analyzed, and herein discuss, the outcomes of and prognostic factors for 35 untreated multiple myeloma patients less than 65 years of age who received induction therapies with bortezomib (Bor) and dexamethasone (BD) for the purpose of up-front autologous peripheral blood stem cell transplantation (SCT). | 25971269 |
| Intestinal Polyposis | Stem Cell Exhaustion | [Multiple myeloma recurring as small intestinal polyposis after autologous hematopoietic stem cell transplantation]. | 25971270 |
| Bone marrow hypocellularity, Thrombosis, Anemia, Hemolytic, Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0 | Stem Cell Exhaustion | Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal hematopoietic stem cell disorder that presents with hemolytic anemia, thrombosis, and bone marrow failure. | 25971274 |
| Multiple Myeloma | Stem Cell Exhaustion | [Successful treatment with pseudo-autologous blood stem cell transplantation for an adolescent-onset multiple myeloma who relapsed after allogenic bone marrow transplantation]. | 25971275 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Peripheral blood stem cells (PBSC) were collected and pseudo-autologous PBSC transplantation (PASCT) was performed following high-dose melphalan without graft-versus-host disease prophylaxis. | 25971275 |
| Behavior, "Huntingtons Disease Pathway | Stem Cell Exhaustion | Reductions in behavioral deficits and neuropathology in the R6/2 mouse model of Huntington's disease following transplantation of bone-marrow-derived mesenchymal stem cells is dependent on passage number. | 25971780 |
| HD Term Type | Stem Cell Exhaustion | Although an effective treatment for HD has remained elusive, current studies using transplants of bone-marrow-derived mesenchymal stem cells provides considerable promise. | 25971780 |
| Amyloidosis | Stem Cell Exhaustion | We designed a prospective, multicentre phase II trial of lenalidomide, dexamethasone and cyclophosphamide for newly diagnosed patients with AL amyloidosis not eligible for autologous stem-cell transplantation. | 25974382 |
| Amyloidosis | Stem Cell Exhaustion | Our results support the efficacy of this regimen, with high quality responses and prolonged survival, as well as its tolerability, in patients with AL amyloidosis not eligible for stem cell transplant and without advanced cardiac involvement (clinicaltrials.gov identifier: NCT01194791). | 25974382 |
| Pancytopenia, Hematological Disease, Aplastic Anemia | Stem Cell Exhaustion | Aplastic anemia is a rare hematopoietic stem-cell disorder that results in pancytopenia and hypocellular bone marrow. | 25975012 |
| Autoimmune reaction, Lupus Vulgaris | Stem Cell Exhaustion | Infusion of Human Bone Marrow-Derived Mesenchymal Stem Cells Alleviates Autoimmune Nephritis in a Lupus Model by Suppressing Follicular Helper T-Cell Development. | 25975931 |
| Encephalitis, St. Louis | Stem Cell Exhaustion | In recent studies, mesenchymal stem cells (MSCs) elicited diverse, even opposing, effects in experimental and clinical SLE. | 25975931 |
| Multiple Myeloma | Stem Cell Exhaustion | Stem cell mobilization and autologous stem cell transplantation after pretreatment with bendamustine, prednisone and bortezomib (BPV) in newly diagnosed multiple myeloma. | 25976868 |
| Toxic effect | Stem Cell Exhaustion | Reliable information on stem cell toxicity and mobilization of stem cells for autologous stem cell transplantation (SCT) after induction treatment with a combination of bendamustine, prednisone and bortezomib (BPV) is missing. | 25976868 |
| Subcutaneous panniculitis-like T-cell lymphoma | Stem Cell Exhaustion | Hematopoietic stem cell transplantation for primary cutaneous gd T-cell lymphoma and refractory subcutaneous panniculitis-like T-cell lymphoma. | 25981001 |
| Stage I Mycosis Fungoides AJCC v7 | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (HSCT) has been shown to be a potentially curative strategy in aggressive TCLs and in refractory and advanced-stage mycosis fungoides. | 25981001 |
| Graft-vs-Host Disease, Aspergillus fumigatus | Stem Cell Exhaustion | We describe an immunosuppressed, 48-year-old male, allogeneic hematopoietic stem cell transplant recipient with severe graft-versus-host disease who developed invasive pulmonary Aspergillus fumigatus infection 6 months after transplant. | 25986028 |
| Neoplasms | Stem Cell Exhaustion | For disseminated tumor cells (DTCs) in the BM, tumor cell dormancy, stem cell-like features and discordant receptor status of DTCs as compared to the primary tumor have been described, explaining the failure of conventional therapies. | 25986892 |
| Myeloproliferative disease, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Chronic myeloid leukemia (CML) is a myeloproliferative disorder of pluripotent stem cells, caused by reciprocal translocation between the long arms of chromosomes 9 and 22, t(9;22)(q34;q11), known as the Philadelphia chromosome. | 25987039 |
| Knee joint | Stem Cell Exhaustion | Since the synovial membrane is abundant with mesenchymal progenitor cells (MPCs) capable of differentiating into cartilage both in vitro and in vivo, we examined if p21 expression levels varied between MPCs derived from normal vs. OA knee joints. | 25987237 |
| Degenerative polyarthritis | Stem Cell Exhaustion | The results of this study suggest that cell cycle regulation in MPCs may be altered in OA and that modulation of this pathway may have therapeutic potential once the mechanism by which this regulates stem/progenitor cells is better understood. | 25987237 |
| Clostridium difficile colitis | Stem Cell Exhaustion | Contribution of Clostridium difficile infection to the development of lower gastrointestinal adverse events during autologous stem cell transplantation. | 25988273 |
| gastrointestinal | Stem Cell Exhaustion | Lower gastrointestinal (GI) adverse events (LGAE) are common afflictions of patients undergoing stem cell transplantation (SCT). | 25988273 |
| Septic Shock | Stem Cell Exhaustion | Donor Nucleotide-Binding Oligomerization-Containing Protein 2 (NOD2) Single Nucleotide Polymorphism 13 Is Associated with Septic Shock after Allogeneic Stem Cell Transplantation. | 25988661 |
| Septic Shock | Stem Cell Exhaustion | In this study, we analyzed 38 patients with septic shock after allogeneic stem cell transplantation (allo-SCT) for an association of SNPs within NOD2 and TLR5 genes, with susceptibility to septic shock. | 25988661 |
| Lupus Erythematosus | Stem Cell Exhaustion | Leptin and Neutrophil-Activating Peptide 2 Promote Mesenchymal Stem Cell Senescence Through Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway in Patients With Systemic Lupus Erythematosus. | 25989537 |
| Lupus Erythematosus, Systemic, Encephalitis, St. Louis | Stem Cell Exhaustion | Mesenchymal stem cells (MSCs) derived from patients with systemic lupus erythematosus (SLE) exhibit enhanced senescence. | 25989537 |
| Lymphoproliferative Disorders | Stem Cell Exhaustion | Is there a difference in post-transplant lymphoproliferative disorder in adults after solid organ and haematologic stem cell transplantation? | 25989696 |
| Post-transplant lymphoproliferative disorder, Lymphoproliferative Disorders | Stem Cell Exhaustion | To determine if there is a difference in post-transplant lymphoproliferative disorder (PTLD) in adults after solid organ transplantation (SOT) and haematologic stem cell transplantation (HST). | 25989696 |
| Sarcopenia | Stem Cell Exhaustion | Reduced insulin sensitivity in childhood survivors of haematopoietic stem cell transplantation is associated with lipodystropic and sarcopenic phenotypes. | 25989749 |
| Acute lymphocytic leukemia, BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 20, BCR gene | Stem Cell Exhaustion | Survivors of childhood acute lymphoblastic leukaemia (ALL) treated with haematopoietic stem cell transplantation and total body irradiation (HSCT/TBI) have a high cardiometabolic risk despite lacking overt clinical obesity. | 25989749 |
| Heart failure | Stem Cell Exhaustion | Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report. | 25990469 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Mesenchymal stem cell therapy for knee osteoarthritis: 5 years follow-up of three patients. | 25990685 |
| herpesvirus 3, human, Simplexvirus | Stem Cell Exhaustion | Low-dose acyclovir prophylaxis for the prevention of herpes simplex virus and varicella zoster virus diseases after autologous hematopoietic stem cell transplantation. | 25990803 |
| varicella zoster, herpesvirus 3, human, Simplexvirus | Stem Cell Exhaustion | Limited data are available on prophylaxis for herpes simplex virus (HSV) and varicella zoster virus (VZV) disease following autologous hematopoietic stem cell transplantation (auto-HCT). | 25990803 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Next, we analyzed 62 follow-up samples from 6 AML patients after therapy and allogeneic stem cell transplantation (alloSCT). | 25994761 |
| leukemia | Stem Cell Exhaustion | It remains to be clarified whether these results simply reflect an accumulation of favorable molecular phenotypes in the AML-ma subgroup or whether they rely on biological differences such as a higher proportion of leukemia stem cells and/or a higher degree of genetic instability within the AML-im subgroup. | 25994787 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | A flow cytometric maturity score was developed in order to distinguish "mature" AML (AML-ma) from "immature" AML (AML-im) by quantitative expression levels of early progenitor cell antigens (CD34, CD117, and TdT). | 25994787 |
| Malignant neoplasm of skin | Stem Cell Exhaustion | Our data indicate for the first time that Numb is involved in the maintenance of the undifferentiated proliferating stem cell pool in the epithelial basal layer and its expression could become a new marker in skin cancer. | 25994834 |
| Ancell-Spiegler cylindromas, Neoplasms | Stem Cell Exhaustion | The occurrence of analogous tumors, dermal cylindromas, and membranous basal cell adenoma of the parotid gland, in the same patient may result from the action of a single gene on ontogenetically similar stem cells. | 25995191 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | Several studies have demonstrated the effect of autologous hematopoietic stem cell transplantation (auto-HSCT) as a salvage treatment for patients with relapsed diffuse large B-cell lymphoma (DLBCL). | 25995667 |
| Granular Dystrophy, Corneal | Stem Cell Exhaustion | Simultaneous transplantation of limbal stem cells may reduce recurrences of granular dystrophy after corneal transplantation: 2 long-term case reports. | 25997048 |
| diabetic | Stem Cell Exhaustion | MicroRNA-130a Targets MAP3K12 to Modulate Diabetic Endothelial Progenitor Cell Function. | 25999017 |
| diabetic | Stem Cell Exhaustion | The aim of the present study was to explore the influence of microRNA (miR)-130a dysregulation on the JNK signal pathway through its target MAP3K12 in diabetic endothelial progenitor cells (EPCs). | 25999017 |
| Brain Neoplasms | Stem Cell Exhaustion | Future studies are needed to evaluate the benefits of MCP-C for particularly burdened groups of caregivers, such as caregivers of patients with brain tumors and those undergoing hematopoietic stem cell transplantations, and to identify target points of delivery that will optimize the intervention's benefits. | 26000705 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Reduced-Intensity Conditioning Combined with (188)Rhenium Radioimmunotherapy before Allogeneic Hematopoietic Stem Cell Transplantation in Elderly Patients with Acute Myeloid Leukemia: The Role of In Vivo T Cell Depletion. | 26001695 |
| Neuropathy | Stem Cell Exhaustion | Treatment choice should take into account specific goals of therapy, necessity for rapid disease control, risk of treatment-related neuropathy, immunosuppression and secondary malignancies, and planning for future autologous stem cell transplantation. | 26002963 |
| Liver Cirrhosis | Stem Cell Exhaustion | Efficacy of autologous mesenchymal stem cell transplantation in patients with liver cirrhosis. | 26006200 |
| Hepatitis C | Stem Cell Exhaustion | In patients with non-responder hepatitis C, HCV RNA levels both became negative after mesenchymal stem cell transplantation. | 26006200 |
| Liver diseases | Stem Cell Exhaustion | Many study results encourage the use of autologous bone marrow-derived mesenchymal stem cells for liver diseases. | 26006200 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Monocytes and macrophages, implications for breast cancer migration and stem cell-like activity and treatment. | 26008983 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Direct treatment of breast cancer cells in homotypic culture was unable to reduce migration or mammosphere formation.Macrophages promote "pro-tumourigenic" cellular characteristics of breast cancer cell migration and stem cell activity. | 26008983 |
| Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Influence of donor age in allogeneic stem cell transplant outcome in acute myeloid leukemia and myelodisplastic syndrome. | 26009156 |
| Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | The impact of donor age in patients with acute myeloid leukemia and myelodysplastic syndrome who underwent allogeneic hematopoietic stem cell transplant (HSCT) remains unclear. | 26009156 |
| Lymphoma | Stem Cell Exhaustion | Phase II Trial of Tandem High-Dose Chemotherapy with Autologous Stem Cell Transplantation Followed by Reduced-Intensity Allogeneic Stem Cell Transplantation for Patients with High-Risk Lymphoma. | 26009261 |
| Lymphoma | Stem Cell Exhaustion | Many patients with lymphoma relapse after autologous stem cell transplantation (AutoSCT). | 26009261 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Ultrasonographic evaluation of gastrointestinal graft-versus-host disease after hematopoietic stem cell transplantation. | 26009803 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Gastrointestinal graft-versus-host disease (GI-GVHD) is a major and life-threatening complication of hematopoietic stem cell transplantation (HSCT). | 26009803 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Acute myeloid leukemia with monosomal karyotype (MK AML) carries a very poor prognosis, even after allogeneic stem cell transplantation (SCT). | 26010466 |
| Liver carcinoma, Hollings Cancer Center | Stem Cell Exhaustion | We aimed to assess the clinicopathological relevance and prognostic significance of expression of the hepatic progenitor cell markers keratin 19 (K19), epithelial cell adhesion molecule (EpCAM) and CD117 (c-KIT) in a White series of hepatocellular carcinoma (HCC). | 26011233 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We describe a 33-year-old man with relapsed acute myelogenous leukemia who developed subcutaneous nodules >6 months after allogeneic hematopoietic stem cell transplant. | 26012493 |
| Rett Syndrome | Stem Cell Exhaustion | Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage. | 26012557 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Control of relapsed or refractory acute myeloid leukemia by clofarabine in preparation for allogeneic stem cell transplant. | 26014275 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Allogeneic stem cell transplant is indicated for patients with refractory or relapsed acute myeloid leukemia (AML). | 26014275 |
| Heart Diseases | Stem Cell Exhaustion | Stem cell therapy shows promise for regeneration in heart disease, yet interpatient variability challenges implementation into practice. | 26014833 |
| Heart failure, Congestive heart failure | Stem Cell Exhaustion | A reduction in number and function of endothelial progenitor cells (EPCs) occurs in both physiologic aging and chronic heart failure (CHF). | 26015451 |
| Lymphoma, Non-Hodgkin | Stem Cell Exhaustion | Autologous stem cell transplantation is commonly used to treat non-Hodgkin's lymphomas (NHLs). | 26018461 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Delta-like 1 homologue (Drosophila) (DLK1) is expressed in malignancies and promotes cancer cell stemness and tumourigenicity, which makes this molecule a potential target for therapies directed against cancer stem/progenitor cells. | 26018510 |
| Specialty Type - cancer | Stem Cell Exhaustion | Combination Treatment with All-Trans Retinoic Acid Prevents Cisplatin-Induced Enrichment of CD133+ Tumor-Initiating Cells and Reveals Heterogeneity of Cancer Stem Cell Compartment in Lung Cancer. | 26020124 |
| Malignant neoplasm of lung, Specialty Type - cancer, CDISC SDTM Lesion Complexity Terminology | Stem Cell Exhaustion | In addition, our approach discloses a further level of complexity of chemotherapy-resistant CD133+ TICs, revealing phenotypical and functional heterogeneity of the cancer stem cell compartment in lung cancer. | 26020124 |
| Glioma, Adult Glioblastoma, Specialty Type - cancer | Stem Cell Exhaustion | Despite few observations, the role of V-ATPase in human tumorigenesis remains unclear.We investigated the expression of ATP6V0C, ATP6V0A2, encoding two subunits belonging to the V-ATPase V0 sector and ATP6V1C, ATP6V1G1, ATPT6V1G2, ATP6V1G3, which are part of the V1 sector, in series of adult gliomas and in cancer stem cell-enriched neurospheres isolated from glioblastoma (GBM) patients. | 26020805 |
| Medial collateral ligament, Mantle cell lymphoma | Stem Cell Exhaustion | We revisited the prognostic value of frequently detected somatic gene copy number alterations (CNAs) in mantle cell lymphoma (MCL) patients treated first line with immunochemotherapy and autologous stem cell transplantation (ASCT), with or without high-dose cytarabine, in the randomized European MCL Younger trial. | 26022239 |
| Heart Diseases | Stem Cell Exhaustion | To investigate whether Tb4 is important in human cardiac disease and has a role in mediating the beneficial cardiac effects of bone-marrow-derived stem cell (BMSC) therapy, we measured serial plasma Tb4 levels in patients enrolled on the REGENERATE-IHD cell therapy trial. | 26022762 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Hematopoietic stem cell transplant (HSCT) is the preferred treatment for young patients with multiple myeloma (MM), but for older adults there is limited evidence on its effectiveness from clinical trials. | 26023094 |
| cell injury | Stem Cell Exhaustion | Local injection of mesenchymal stem cells protects testicular torsion-induced germ cell injury. | 26025454 |
| Infertility | Stem Cell Exhaustion | The effects of mesenchymal stem cells (MSCs) on acute tissue injury have been demonstrated, and the abilities of paracrine support, differentiation and immune-modulation may benefit to testicular torsion-induced infertility. | 26025454 |
| MYELODYSPLASTIC SYNDROME, Impaired T cell function | Stem Cell Exhaustion | Endothelial progenitor cell dysfunction in myelodysplastic syndromes: possible contribution of a defective vascular niche to myelodysplasia. | 26025663 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | Role of cytomegalovirus (CMV)-specific polyfunctional CD8+ T-cells and antibodies neutralizing virus epithelial infection in the control of CMV infection in an allogeneic stem-cell transplantation setting. | 26025872 |
| Leukemia, Myelocytic, Acute, Multiple Myeloma | Stem Cell Exhaustion | AML transformation after autologous stem cell transplant for multiple myeloma. | 26025976 |
| Colorectal Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Correlation of HIWI and HILI Expression with Cancer Stem Cell Markers in Colorectal Cancer. | 26026091 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cells (CSCs) constitute a sub-population of tumor cells that possess stem cell properties, such as self-renewal and the ability of differentiation. | 26026091 |
| Colorectal Carcinoma, Specialty Type - cancer, Cytogenetic Complete Response | Stem Cell Exhaustion | The aim of the study was to evaluate the clinical significance of the HIWI and HILI expression and its relationship with cancer stem cells markers in 72 patients with colorectal carcinoma (CRC). | 26026091 |
| Specialty Type - cancer | Stem Cell Exhaustion | The expression level of HIWI and HILI and cancer stem cells markers in paired cancerous and non-cancerous tissues was measured by real-time reverse transcription-polymerase chain reaction (RT-PCR) assay. | 26026091 |
| Osteoporotic Fractures | Stem Cell Exhaustion | A set of these and of other miRNAs known to change in the context of osteoporotic fractures were subsequently tested for their effects on osteogenic differentiation of human mesenchymal stem cells (MSCs) in vitro. | 26026730 |
| Myeloproliferative disease, Primary Myelofibrosis, PMF Regimen | Stem Cell Exhaustion | Primary myelofibrosis (PMF) is a rare myeloproliferative stem cell disorder. | 26027540 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Allogeneic stem cell transplantation (ASCT) is a complex medical procedure for some patients with hematologic malignancies. | 26028503 |
| Leukemia, Myelocytic, Acute, Complement Membrane Attack Complex | Stem Cell Exhaustion | In recipients of allogeneic hematopoietic stem cell transplantation with AML in CR1, reduced intensity (RIC) conditioning regimens are usually given to older patients and myeloablative regimens (MAC) to younger patients. | 26030052 |
| Hepatitis B | Stem Cell Exhaustion | Hepatitis B virus (HBV) reactivation (so-called reverse seroconversion) is a rare but known complication of hematopoietic stem cell transplantation, immunosuppressive therapy, or high-dose chemotherapy plus rituximab. | 26031455 |
| Bronchiolitis Obliterans | Stem Cell Exhaustion | Effect of extracorporeal photopheresis on lung function decline for severe bronchiolitis obliterans syndrome following allogeneic stem cell transplantation. | 26031713 |
| Posterior reversible encephalopathy syndrome | Stem Cell Exhaustion | There were 55% who received chemotherapy or targeted therapy within the month preceding PRES, including 6 patients who received bevacizumab; PRES followed allogeneic stem cell transplantation in 5 (16%). | 26032137 |
| Neoplasms | Stem Cell Exhaustion | Of the patients 29 had solid tumors and 5 underwent hematopoietic stem cell transplantation for benign disease. | 26032139 |
| Spinal Cord Injuries | Stem Cell Exhaustion | To examine how trusted communication between individuals with spinal cord injury (ISCIs) and physicians who care for ISCIs is affected by the discussion of advances in stem cell research and interventions locally and abroad. | 26032752 |
| Spinal Cord Injuries | Stem Cell Exhaustion | Perspectives on strategies and challenges in the conversation about stem cells for spinal cord injury. | 26032752 |
| Stanford Cancer Institute, Spinal Cord Injuries | Stem Cell Exhaustion | A convergence of factors involving transparency impact trusted communication between ISCIs and physicians about stem cells and spinal cord injury (SCI). | 26032752 |
| Stanford Cancer Institute | Stem Cell Exhaustion | (2) A new generation of innovations in research and clinical trial dissemination about stem cells for SCI is needed to remedy the perceived inadequacies of existing information content and accessibility. | 26032752 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | In the past decade, the number of autologous hematopoietic stem cell transplants (Auto HSCT) for older patients with multiple myeloma (MM) has increased dramatically, as has the cost of transplantation. | 26033281 |
| Liver diseases | Stem Cell Exhaustion | Upregulation of osteopontin (OPN) has been found in hepatic progenitor cells (HPCs) in several liver diseases with portal biliary proliferation. | 26033745 |
| Liver | Stem Cell Exhaustion | Epithelial cell adhesion molecule EpCAM(+) CD45(-) cells isolated from mouse liver and liver epithelial progenitor cells were used for in vitro study. | 26033745 |
| Ischemic, Peripheral Ischemia | Stem Cell Exhaustion | In a murine model of peripheral ischemia, systemic gene therapy with longevity-associated variant-BPIFB4 promotes the recruitment of hematopoietic stem cells, reparative vascularization, and reperfusion of the ischemic muscle. | 26034043 |
| Aggressive Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Prognostic Value of FDG PET/CT before Allogeneic and Autologous Stem Cell Transplantation for Aggressive Lymphoma. | 26035588 |
| Aggressive Non-Hodgkin Lymphoma | Stem Cell Exhaustion | To determine the prognostic value of performing fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) before allogeneic and autologous stem cell transplantation (SCT) in patients with aggressive lymphoma. | 26035588 |
| Sarcoidosis, Pulmonary | Stem Cell Exhaustion | CD34+ progenitor cells in pulmonary sarcoidosis. | 26039017 |
| Sarcoidosis, Pulmonary | Stem Cell Exhaustion | It has been shown that number of CD34+ progenitor cells in peripheral blood was significantly higher in patients with newly diagnosed pulmonary sarcoidosis and showed a positive correlation with CD4/ CD8 rate. | 26039017 |
| Sarcoidosis | Stem Cell Exhaustion | CD34+ progenitor cells may be important in the pathogenesis of sarcoidosis. | 26039017 |
| Acute leukemia | Stem Cell Exhaustion | Clinical trials have shown that a strategy for haploidentical transplantation based on the infusion of high numbers of T-cell-depleted hematopoietic progenitor cells and no post-transplant immunosuppression controls graft rejection and GvHD in patients with acute leukemia. | 26039200 |
| Failure, Acute leukemia | Stem Cell Exhaustion | Relapse is still the major cause of failure of allogeneic stem cell transplantation in high-risk acute leukemia patients. | 26039211 |
| varicella zoster | Stem Cell Exhaustion | A Japanese single-hospital observational trial with a retrospective case-control analysis of varicella zoster virus reactivation after autologous peripheral blood stem cell transplantation. | 26041667 |
| varicella zoster, herpesvirus 3, human | Stem Cell Exhaustion | Varicella zoster virus (VZV) reactivation following hematopoietic stem cell transplantation (SCT) is common. | 26041667 |
| Squamous cell carcinoma, Trauma Symptom Checklist for Children Questionnaire | Stem Cell Exhaustion | In the present study, the expression of BMI1, which controls self-renewal in stem cells, as well as that of ZEB1, a transcription factor that regulates EMT, was evaluated for its role in EMT and the carcinogenic processes of tongue squamous cell carcinoma (TSCC). | 26043676 |
| Specialty Type - cancer | Stem Cell Exhaustion | Differential Expression of Cancer Stem Cell Markers ALDH1 and CD133 in Various Lung Cancer Subtypes. | 26046383 |
| Malignant neoplasm of lung | Stem Cell Exhaustion | Clinicopathological significance of stem cell markers CD133 and ALDH1 in a large group of lung cancer patients was evaluated. | 26046383 |
| Malignant neoplasm of lung, Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells (CSCs) are hypothesized to be the main culprit of lung cancer progression. | 26046383 |
| Crohn Disease | Stem Cell Exhaustion | Long-Term Follow-Up of Crohn Disease Fistulas After Local Injections of Bone Marrow-Derived Mesenchymal Stem Cells. | 26046409 |
| Chronic heart failure, Congestive heart failure | Stem Cell Exhaustion | To assess content of various subpopulations of endothelial progenitor cells (EPC) with CD45-CD34+, CD14+CD309+ and CD14+CD309+Tie2+ phenotypes in patients with chronic heart failure (CHF) of ischemic origin with preserved left ventricular ejection fraction. | 26050484 |
| Herpes Simplex Infections | Stem Cell Exhaustion | Thirteen patients with limbal stem cell deficiency after unilateral (9 eyes) or bilateral (2 eyes) chemical burn, liquid nitrogen injury (1 eye), or herpes simplex virus infection (1 eye). | 26050542 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (HSCT) is one of curative treatment options for patients with hematologic malignancies. | 26052909 |
| Central neuroblastoma, South Ndebele language | Stem Cell Exhaustion | The aim of the study was to evaluate arterial morphology and function in a national cohort of long-term survivors of high-risk neuroblastoma (NBL) treated with high-dose chemotherapy and autologous hematopoietic stem cell transplantation with or without total body irradiation (TBI). | 26052933 |
| Multiple Myeloma | Stem Cell Exhaustion | We conducted a retrospective analysis of 102 patients with myeloma who were ineligible for haematopoietic stem cell transplantation between October 2000 and December 2012. | 26053837 |
| Osteolysis, Adipose Tissue Atrophy | Stem Cell Exhaustion | (3) Are these two abnormalities (bone osteolysis and fatty atrophy) associated with a decrease of mesenchymal stem cells (MSCs) in bone and in muscle? | 26054482 |
| leukemia, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Maintenance Therapy with Decitabine after Allogeneic Stem Cell Transplantation for Acute Myelogenous Leukemia and Myelodysplastic Syndrome. | 26055299 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Current treatments for acute myeloid leukemia (AML) are designed to target rapidly dividing blast populations with limited success in eradicating the functionally distinct leukemia stem cell (LSC) population, which is postulated to be responsible for disease resistance and relapse. | 26055302 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Targeting leukemia stem cells in vivo with antagomiR-126 nanoparticles in acute myeloid leukemia. | 26055302 |
| lymphoblast | Stem Cell Exhaustion | Despite the dismal outcome, acute lymphoblastic leukemia-type therapy (with central nervous system prophylaxis) and/or allogeneic stem cell transplantation appeared to be the only effective therapies. | 26056082 |
| Hematologic Neoplasms | Stem Cell Exhaustion | To characterize the impact of graft T-cell composition on outcomes of reduced-intensity conditioned (RIC) allogeneic hematopoietic stem-cell transplantation (alloHSCT) in adults with hematologic malignancies. | 26056179 |
| Specialty Type - cancer | Stem Cell Exhaustion | We begin by reanalysing a recently published dataset to separate the effects of stem cell number and replication rate, and show that each has an independent effect on cancer risk. | 26056357 |
| Specialty Type - cancer | Stem Cell Exhaustion | When considering the lifetime number of stem cell divisions in an extended dataset, and removing cases associated with other diseases or carcinogens, we find that lifetime cancer risk per tissue saturates at approximately 0.3-1.3% for the types considered. | 26056357 |
| Specialty Type - cancer | Stem Cell Exhaustion | Our results indicate that cancer risk depends not only on the number of stem cell divisions but varies enormously (approx. | 26056357 |
| Colorectal Carcinoma | Stem Cell Exhaustion | Analysis of previously published models of colorectal cancer suggests that a two- to three-fold decrease in the mutation rate or stem cell division rate is enough to reduce a whale's cancer risk to that of a human. | 26056366 |
| Thrombosis | Stem Cell Exhaustion | Conservative Management of Downhill Esophageal Varices Secondary to Central Line-related Thrombosis After Hematopoietic Stem Cell Transplant. | 26056785 |
| Chest Pain, Fever, Coughing | Stem Cell Exhaustion | A 47-year-old stem cell transplant recipient with fever, cough and chest pain. | 26057372 |
| Infection, Malignant Neoplasms | Stem Cell Exhaustion | Infections and malignancies are among the most serious complications that follow organ or stem cell transplantation. | 26057372 |
| Lung diseases | Stem Cell Exhaustion | The present article describes a case of symptomatic nodular pulmonary disease that complicated hematopoietic stem cell transplantation. | 26057372 |
| Neoplasms | Stem Cell Exhaustion | The association between GPC-3 and SALL-4 is a novel finding and suggests that GPC-3 targeting may specifically attack the tumour stem-cell compartment. | 26057582 |
| Degenerative polyarthritis | Stem Cell Exhaustion | This study aims to investigate the safety of treatment with autologous bone marrow (BM)-derived mesenchymal stem cells (MSCs) transplanted in patients with OA of the knee, ankle, or hip. | 26058927 |
| Respiratory Syncytial Virus Infections | Stem Cell Exhaustion | Adult patients with respiratory syncytial virus infection: impact of solid organ and hematopoietic stem cell transplantation on outcomes. | 26059180 |
| Osteoporosis | Stem Cell Exhaustion | SWI/SNF-Mediated Lineage Determination in Mesenchymal Stem Cells Confers Resistance to Osteoporosis. | 26059320 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | ABCG2 overexpression in patients with acute myeloid leukemia: Impact on stem cell transplantation outcome. | 26059733 |
| Gastrointestinal Stromal Tumors, Neoplasms, Gastrointestinal tract structure | Stem Cell Exhaustion | Gastrointestinal mesenchymal tumours are a group of tumours originating from the mesenchymal stem cells of the gastrointestinal (GI) tract. | 26060170 |
| Pterygium | Stem Cell Exhaustion | It is not clear whether demographic or pterygium characteristics or limbal stem cell deficiency determine pterygium recurrence after surgery. | 26060460 |
| Pterygium | Stem Cell Exhaustion | To determine whether the demographic, pterygium characteristics, or limbal stem cell deficiency determine pterygium recurrence after excision. | 26060460 |
| Anemia, Chronic disease | Stem Cell Exhaustion | Anemia of chronic disease (ACD) is thought to impair the responsiveness of erythroid progenitor cells, but research has shown treatment with recombinant human erythropoietin (rhuEPO) can improve patient hemoglobin levels and, subsequently, overall patient health status and quality of life. | 26061404 |
| Fibrosis Assessment, Erectile dysfunction | Stem Cell Exhaustion | Intratunical Injection of Genetically Modified Adipose Tissue-Derived Stem Cells with Human Interferon a-2b for Treatment of Erectile Dysfunction in a Rat Model of Tunica Albugineal Fibrosis. | 26062100 |
| Fibrosis Assessment, IGFBP7 protein, human | Stem Cell Exhaustion | To investigate the efficacy of intratunical injection of genetically modified rat adipose tissue-derived stem cells (ADSCs) expressing human interferon a-2b (ADSCs-IFN) in decreasing fibrosis and restoring erectile function in a rat model of tunica albugineal fibrosis (TAF). | 26062100 |
| Specialty Type - cancer | Stem Cell Exhaustion | The effectiveness of caregiver social support is associated with cancer survivors' memories of stem cell transplantation: A linguistic analysis of survivor narratives. | 26062657 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disorder characterized by dysplastic changes in the bone marrow, ineffective erythropoiesis, and an increased risk of developing acute myeloid leukemia. | 26063191 |
| Retinal Diseases | Stem Cell Exhaustion | Mesenchymal stem cells (MSCs) are currently being investigated as a treatment for several such retinal diseases based on their neuroprotective and angiogenic potentials. | 26065854 |
| Colorectal Carcinoma, Specialty Type - cancer, Secondary malignant neoplasm of liver, Carcinomatosis | Stem Cell Exhaustion | Cancer Stem Cell Markers Are Associated With Distant Hematogenous Liver Metastases But Not With Peritoneal Carcinomatosis in Colorectal Cancer. | 26068177 |
| Secondary malignant neoplasm of liver, Specialty Type - cancer, Cytogenetic Complete Response | Stem Cell Exhaustion | To analyze the expression of cancer stem cell markers immunohistochemistry for CD133, CD44 and b-catenin was applied to CRC with exclusive PC, exclusive hepatic metastasis and CRC with combined spread. | 26068177 |
| Specialty Type - cancer | Stem Cell Exhaustion | Expression of cancer stem cell markers correlated with hematogeneous metastases to the liver and was absent in patients with exclusive PC. | 26068177 |
| Specialty Type - cancer, Cytogenetic Complete Response | Stem Cell Exhaustion | Thus, expression of cancer stem cell markers correlates with different patterns of metastatic spread in CRC. | 26068177 |
| Cytogenetic Complete Response | Stem Cell Exhaustion | These data indicate that CRC with exclusive PC lack stem cell features needed for distant dissemination. | 26068177 |
| Neoplasms | Stem Cell Exhaustion | We first aimed to generate transformed cell lines from a human induced pluripotent stem cell (hiPSC)-teratoma, and then examined the tumorigenic risks of the differentiated cells from hiPSC explant, because hiPSC-derivatives give rise to tumors in immune-deficient mice when transplanted. | 26069211 |
| Coronavirus Infections, Hematologic Neoplasms | Stem Cell Exhaustion | The clinical impact of coronavirus infection in patients with hematologic malignancies and hematopoietic stem cell transplant recipients. | 26071326 |
| Hematologic Neoplasms, Communicable Diseases | Stem Cell Exhaustion | Compared to other respiratory viruses, relatively little is known about the clinical impact of coronavirus (CoV) infection after hematopoietic stem cell transplant (HSCT) or in patients with hematologic malignancies. | 26071326 |
| Lymphoma | Stem Cell Exhaustion | Vorinostat Combined with High-Dose Gemcitabine, Busulfan, and Melphalan with Autologous Stem Cell Transplantation in Patients with Refractory Lymphomas. | 26071868 |
| TRPV6 wt Allele, T-cell leukemia-lymphoma gene | Stem Cell Exhaustion | Despite the remarkable advances in chemotherapy and allogeneic hematopoietic stem cell transplantation (HSCT), adult T-cell leukemia-lymphoma (ATL) is still associated with a high mortality rate. | 26073237 |
| diabetic | Stem Cell Exhaustion | Rivaroxaban promoted vessel formation in diabetic mice and improved endothelial progenitor cell function under hyperglycemic conditions. | 26077117 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | Expression of CD47 and CD44, a known gastric cancer stem cell marker, were investigated in gastric cancer cell lines by flow cytometry. | 26077800 |
| Traumatic AND/OR non-traumatic injury | Stem Cell Exhaustion | A 4-year-old boy developed unilateral, total limbal stem cell deficiency (LSCD) following an acid injury. | 26082100 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Outcome of allogeneic hematopoietic stem-cell transplantation for adult patients with AML and 11q23/MLL rearrangement (MLL-r AML). | 26082270 |
| Acute Myeloid Leukemia with Myelodysplasia-Related Changes, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplant overcomes poor prognosis of acute myeloid leukemia with myelodysplasia-related changes. | 26084204 |
| Specialty Type - cancer, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | The cancer stem cell (CSC) hypothesis suggests that a subset of cancer cells possesses stem cell properties and is crucial in tumor initiation, metastasis, and drug resistance. | 26086949 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | To determine the mechanism of CSCs in breast cancer, we focused on LGR5, a marker of adult stem cells that potentially serves as a functional factor in CSCs. | 26086949 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | Quality of life related to oral mucositis of patients undergoing haematopoietic stem cell transplantation and receiving specialised oral care with low-level laser therapy: a prospective observational study. | 26087364 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | Oral mucositis is a painful condition that occurs in 80% of patients who undergo haematopoietic stem cell transplantation (HSCT). | 26087364 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Areca nut contributes to oral malignancy through facilitating the conversion of cancer stem cells. | 26087469 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | In conclusion, our findings suggested that areca nut contributes to oral malignancy through facilitating the conversion of cancer stem cells. | 26087469 |
| Malignant Neoplasms | Stem Cell Exhaustion | [Effectiveness of high-dose polychemotherapy with autologous hemopoietic stem cell transplantation in the treatment for malignant tumors of the central nervous system in children and young adults]. | 26087603 |
| Malignant neoplasm of brain | Stem Cell Exhaustion | A total of 40 patients (median age 6 years, range 1-28 years) with high-risk malignant brain tumors received a single (n = 35) or tandem (n = 5) high-dose chemotherapy (HDCT) with autologous hemopoietic stem cell transplantation (auto-HSCT). | 26087603 |
| Adrenoleukodystrophy | Stem Cell Exhaustion | Transplantation of haploidentical stem cells combined with the infusion of umbilical cord blood is a novel approach for treating cerebral X-linked adrenoleukodystrophy. | 26088837 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | When clinically feasible, immune suppression tapering alone in patients who relapse early after reduced intensity conditioning allogeneic stem cell transplantation can produce durable remissions, but is almost always associated with graft-versus-host disease. | 26088931 |
| Chronic graft-versus-host disease | Stem Cell Exhaustion | Ocular chronic graft-versus-host disease is one of the most bothersome common complications following allogeneic hematopoietic stem cell transplantation. | 26088932 |
| Chronic graft-versus-host disease | Stem Cell Exhaustion | These results support the use of selected transplant clinician- and patient-reported outcome measures for ocular chronic graft-versus-host disease screening when providing care to allogeneic hematopoietic stem cell transplantation survivors with moderate to severe chronic graft-versus-host disease. | 26088932 |
| Kidney Diseases | Stem Cell Exhaustion | Circulating Endothelial Progenitor Cell Levels Predict Cardiovascular Events in End-Stage Renal Disease Patients on Maintenance Hemodialysis. | 26089157 |
| Toxic effect | Stem Cell Exhaustion | Increased toxicity in older patients limits the delivery of standard consolidation therapies, such as allogeneic stem cell transplant or high-dose cytarabine. | 26089240 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | T-cell-depleted (TCD) allogeneic hematopoietic stem cell transplantation demonstrates similar efficacy and reduced incidence and severity of graft-versus-host disease (GVHD) in appropriately selected patients versus T-cell-replete transplantation. | 26091510 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | The histopathology of cutaneous acute GVHD (aGVHD) after TCD peripheral blood stem cell transplants (PBSCTs) is not described. | 26091510 |
| Colonic Neoplasms | Stem Cell Exhaustion | Human colon CSCs have increased mitochondrial function compared with colon tumor cells without stem cell properties. | 26091938 |
| Specialty Type - cancer, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Reagents designed to target cancer stem cells (CSCs) could reduce tumor growth, recurrence, and metastasis. | 26091938 |
| Colorectal Carcinoma, Specialty Type - cancer, Secondary Neoplasm, Secondary malignant neoplasm of liver | Stem Cell Exhaustion | Expression of cancer stem cell markers in metastatic colorectal cancer correlates with liver metastasis, but not with metastasis to the central nervous system. | 26092596 |
| Colorectal Carcinoma, Neoplasms, Cytogenetic Complete Response | Stem Cell Exhaustion | In colorectal cancer (CRC), metastatic spread is supposed to be mainly driven by tumor cells with stem cell features. | 26092596 |
| Specialty Type - cancer | Stem Cell Exhaustion | The present study intended to analyze the correlation between the expression of cancer stem cell markers and patterns of liver or CNS metastases. | 26092596 |
| Specialty Type - cancer | Stem Cell Exhaustion | Combination of cancer stem cell markers revealed high discriminatory power for the prediction of different patterns of distant spread. | 26092596 |
| Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | This study demonstrates that deregulation of Wnt/b-catenin-signaling and high-grade expression of cancer stem cell markers correlate with metastasis to the liver, but not to the CNS. | 26092596 |
| Specialty Type - cancer | Stem Cell Exhaustion | In the present study, we found endogenous and secretory annexin A3 (ANXA3) to play pivotal roles in promoting cancer and stem cell-like features in CD133+ liver CSCs through a dysregulated JNK pathway. | 26095609 |
| Liver carcinoma, Neoplasms, Specialty Type - cancer, Hollings Cancer Center | Stem Cell Exhaustion | Frequent tumor relapse in hepatocellular carcinoma (HCC) has been commonly attributed to the presence of residual cancer stem cells (CSCs) after conventional treatments. | 26095609 |
| Malignant Neoplasms | Stem Cell Exhaustion | Zinc-finger protein X-linked (ZFX), a novel transcription factor required for self-renewal of embryonic stem cells, has recently been implicated in the initiation and progression of various human malignancies. | 26097576 |
| Malignant Neoplasms | Stem Cell Exhaustion | Stem cell transplant (SCT), considered the current standard of care for adults with advanced cancers, can lead to substantial deconditioning and diminished well-being. | 26098401 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | High-dose melphalan (MEL) is the standard therapy for autologous stem cell transplantation (ASCT) in multiple myeloma (MM), although the optimal conditioning regimen remains yet to be identified. | 26099830 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Superiority of allogeneic hematopoietic stem cell transplantation to nilotinib and dasatinib for adult patients with chronic myelogenous leukemia in the accelerated phase. | 26100855 |
| Lymphoma | Stem Cell Exhaustion | Prognostic value of Positron Emission Tomography/Computed Tomography in patients with Lymphoma treated with autologous stem cell transplantation (ASCT) for relapsed/refractory or high risk disease. | 26101430 |
| Lymphoma | Stem Cell Exhaustion | Positron Emission Tomography/Computed Tomography (PET/CT scan) has increasingly been used for management of lymphoma, however few and conflicting data have been provided in the setting of high dose therapy with autologous stem cell transplantation (ASCT) so far. | 26101430 |
| Liver Cirrhosis, RPS19 gene | Stem Cell Exhaustion | Successful use of reduced-intensity conditioning and matched-unrelated hematopoietic stem cell transplant in a child with Diamond-Blackfan anemia and cirrhosis. | 26103586 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma, Communicable Diseases | Stem Cell Exhaustion | We defined the epidemiology and clinical predictors of infection in patients with multiple myeloma (MM) receiving immunomodulatory drugs (IMiDs), proteasome inhibitors (PI) and autologous haematopoietic stem cell transplant (ASCT) in a large longitudinal cohort study. | 26105211 |
| Prostate carcinoma, Androgen-sensitive | Stem Cell Exhaustion | These findings identify loss of miR-34b as a robust biomarker for prostate cancer progression in androgen-sensitive tumors, and anticipate a potential role of progenitor/stem cell signaling in this stage of disease. | 26107383 |
| Multiple Myeloma | Stem Cell Exhaustion | Changes in circulating endothelial progenitor cells predict responses of multiple myeloma patients to treatment with bortezomib and dexamethasone. | 26108099 |
| Lymphoma | Stem Cell Exhaustion | Salvage chemotherapy and autologous stem cell transplantation for transformed indolent lymphoma: a subset analysis of NCIC CTG LY12. | 26109202 |
| HYPERPIGMENTATION, FAMILIAL PROGRESSIVE | Stem Cell Exhaustion | IFNL induction was studied in primary human hepatocytes (PHH) from 18 human donors, peripheral blood mononuclear cells (PBMCs) from 18 human donors, multiple cell lines and induced pluripotent stem cell-derived hepatocyte-like cells (iPSC-hepatocytes) from 7 human donors. | 26109548 |
| Celiac Disease | Stem Cell Exhaustion | A 37-year-old woman with refractory coeliac disease type II disease treated by stem cell transplantation. | 26109624 |
| Liver Carcinosarcoma | Stem Cell Exhaustion | A liver progenitor cell origin of the liver carcinosarcoma was proposed. | 26109824 |
| Hollings Cancer Center, Aggressive behavior, Specialty Type - cancer | Stem Cell Exhaustion | Taken together, our results support the conclusion that gSMA expression in HCC is strongly correlated with the EMT process, HCC aggressiveness and the identification of cancer stem cells. | 26110787 |
| Neoplasms | Stem Cell Exhaustion | Interestingly, this expression was significantly correlated with poor tumour differentiation and progenitor cell features characterized by the expression of EpCAM and K19. | 26110787 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Mesenchymal stem cell implantation in knee osteoarthritis: an assessment of the factors influencing clinical outcomes. | 26113522 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Several clinical studies have reported on cell-based treatment using mesenchymal stem cells (MSCs) for cartilage regeneration in knee osteoarthritis (OA). | 26113522 |
| Keratopathy, Fibrosis Assessment | Stem Cell Exhaustion | Slit lamp examination revealed diffuse conjunctivalisation of the ocular surface with mild subepithelial fibrosis consistent with aniridic keratopathy secondary to limbal stem cell deficiency. | 26113596 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | These tumors may include a malignant heterologous component that is believed to originate through a process of multidirectional differentiation from a cancer stem cell. | 26113664 |
| diabetic, Diabetic Retinopathy | Stem Cell Exhaustion | Expression of Angiogenic MicroRNAs in Endothelial Progenitor Cells From Type 1 Diabetic Patients With and Without Diabetic Retinopathy. | 26114486 |
| GDC Disease Response Terminology, Diabetes Mellitus, Insulin-Dependent, IGHD1-7 gene, Diabetic Retinopathy | Stem Cell Exhaustion | MicroRNA (miR) expression in endothelial progenitor cells (EPCs) in type 1 diabetes (DM1) and its relation with different stages of diabetic retinopathy (DR) have not been reported to date. | 26114486 |
| Specialty Type - cancer | Stem Cell Exhaustion | Epigenetic reprogramming that imparts functional changes in gene expression, the development of cancer stem cells, and immunomodulation are plausible underlying mechanisms by which early-life iAs exposure elicits latent carcinogenic effects. | 26115410 |
| Lymphoma, Non-Hodgkin | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplantation in elderly patients (>= 70 years) with non-Hodgkin's lymphoma: A French Society of Bone Marrow Transplantation and Cellular Therapy retrospective study. | 26116168 |
| Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin | Stem Cell Exhaustion | Limited data is available on the feasibility of high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (AHSCT) in elderly patients over 70 years of age with non-Hodgkin's lymphoma (NHL). | 26116168 |
| nervous system disorder | Stem Cell Exhaustion | Umbilical cord mesenchymal stem cells in neurological disorders: A clinical study. | 26118125 |
| Neoplasms | Stem Cell Exhaustion | The tumor demonstrated robust immunohistochemical expression of multiple markers of embryonic/neural stem cells and embryogenesis from the paraffin embedded tissue. | 26118758 |
| Interstitial keratitis, Corneal Opacity | Stem Cell Exhaustion | In addition to previously reported crystalline, nummular, patch-like, and lattice-like corneal opacities, prominent corneal vascularization was present in 2 patients mimicking interstitial keratitis and limbal stem cell deficiency. | 26118999 |
| Specialty Type - cancer, Multiple Myeloma | Stem Cell Exhaustion | Multiple myeloma is an incurable cancer commonly treated with stem cell transplantation (SCT). | 26119495 |
| Intrahepatic bile duct, Fibrosis of bile duct | Stem Cell Exhaustion | We aimed to study the biliary tree stem cell compartment located in peribiliary glands of extrahepatic and large intrahepatic bile ducts and its role in the pathogenesis of biliary fibrosis in PSC. | 26119688 |
| Fibrosis Assessment | Stem Cell Exhaustion | The biliary tree stem cell compartment is activated in PSC, its activation contributes to biliary fibrosis, and is sustained by the Hedgehog pathway. | 26119688 |
| Cholangitis | Stem Cell Exhaustion | Activation of biliary tree stem cells within peribiliary glands in primary sclerosing cholangitis. | 26119688 |
| Biliary hyperplasia | Stem Cell Exhaustion | Hyperplasia of peribiliary glands was determined by the expansion of biliary tree stem cells, which sprouted towards the surface epithelium. | 26119688 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | It has been shown that the mammary luminal lineage could be maintained by luminal stem cells or long-lived progenitors, but their identity and role in breast cancer remain largely elusive. | 26120057 |
| Multiple Myeloma | Stem Cell Exhaustion | Salvage bortezomib-dexamethasone and high-dose melphalan (HDM) and autologous stem cell support (ASCT) in myeloma patients at first relapse after HDM with ASCT. | 26121108 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Lower dose anti-thymocyte globulin for GvHD prophylaxis results in improved survival after allogeneic stem cell transplantation. | 26121111 |
| Bronchiolitis Obliterans | Stem Cell Exhaustion | The efficacy of prophylactic azithromycin on bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation. | 26121954 |
| Bronchiolitis Obliterans, Bosnian language | Stem Cell Exhaustion | The aim of this study was to determine whether prophylactic azithromycin treatment prevents bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplantation (HCT). | 26121954 |
| Neoplasms | Stem Cell Exhaustion | We demonstrated that elevated CRMP5 promotes Notch receptor expression and Akt activation in human tumor cell lines, GBM stem cells, and primary tumor biopsies. | 26122847 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | Mesenchymal stem cells (MSCs), which may be obtained from the bone marrow, have been studied for more than a decade in the setting of coronary artery disease (CAD). | 26123356 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | The cancer stem cell hypothesis postulates that a minute fraction of cells within a tumor, termed cancer stem cells (CSCs), have a tumor-initiating capacity that propels tumor growth. | 26124098 |
| Specialty Type - cancer | Stem Cell Exhaustion | Drug-eluting microarrays to identify effective chemotherapeutic combinations targeting patient-derived cancer stem cells. | 26124098 |
| Non-alcoholic Fatty Liver Disease, Inflammation | Stem Cell Exhaustion | Portal inflammation during NAFLD is frequent and associated with the early phases of putative hepatic progenitor cell activation. | 26124313 |
| Non-alcoholic Fatty Liver Disease, Inflammation | Stem Cell Exhaustion | We investigated whether portal tract inflammation observed in non-alcoholic fatty liver disease (NAFLD) is associated with hepatic progenitor cell compartment activation, as thoroughly evaluated with different markers of the staminal lineage. | 26124313 |
| Interlobular bile duct | Stem Cell Exhaustion | Putative hepatic progenitor cells, intermediate hepatobiliary cells and bile ductules/interlobular bile ducts were evaluated by immunohistochemistry for cytokeratin (CK)-7, CK-19 and epithelial cell adhesion molecule (EpCAM), and a hepatic progenitor cell compartment score was derived. | 26124313 |
| Inflammation, Portal inflammation | Stem Cell Exhaustion | Lobular inflammation, ballooning, myofibroblast activity and hepatic progenitor cell compartment activation were associated with portal inflammation by univariate analysis. | 26124313 |
| Portal inflammation | Stem Cell Exhaustion | In the multivariate model, the only variable independently associated with portal inflammation was hepatic progenitor cell compartment activation (OR 3.7, 95% CI 1.1 to 12.6). | 26124313 |
| Interlobular bile duct, Inflammation | Stem Cell Exhaustion | Portal inflammation correlated with CK-7-counted putative hepatic progenitor cells (r=0.48, p<0.001), intermediate hepatobiliary cells (r=0.6, p<0.001) and bile ductules/interlobular bile ducts (r=0.6, p<0.001), and with the activity of myofibroblasts (r=0.5, p<0.001). | 26124313 |
| Non-alcoholic Fatty Liver Disease, Fibrosis Assessment, Inflammation | Stem Cell Exhaustion | Portal inflammation is frequent during NAFLD and strongly associated with activation of putative hepatic progenitor cells since the first steps of their differentiation, portal myofibroblast activity and fibrosis. | 26124313 |
| Esophageal carcinoma | Stem Cell Exhaustion | We examined two receptor tyrosine kinases, platelet-derived growth factor receptor (PDGFR-a) and mast/stem cell growth factor receptor (CD117) in esophageal carcinomas. | 26124324 |
| Erythema, Fungal pneumonia, Leukemia, Myelocytic, Acute, Necrosis, Leukocytosis | Stem Cell Exhaustion | We report the case of a 52-year-old man with primary refractory acute myelogenous leukemia (AML) following allogeneic stem cell transplant (SCT) who presented with a progressive reddish purple nodule with surrounding erythema and central necrosis in the setting of leukocytosis and possible fungal pneumonia. | 26125209 |
| Neutropenia, Liver Failure, Kidney Failure, Acute, Candidiasis, Neoplasms, Immunocompromised Host | Stem Cell Exhaustion | Patients with invasive Candida infections were more likely to have had an immunocompromised state, hematopoietic stem cell transplantation, solid organ transplant, solid tumor, chemotherapy within the past three months, neutropenia, surgery within the past 30 days, acute renal failure, liver failure, and/or median baseline serum creatinine. | 26125894 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Myelodysplastic Syndromes (MDS) are a group of clonal hematopoietic stem cell disorders with significant heterogeneity in their clinical presentation and the prognosis of the patients. | 26126819 |
| Acute leukemia | Stem Cell Exhaustion | The interleukin-3 receptor a-chain (CD123) is highly expressed on the surface of acute leukemia cells compared with normal hematopoietic stem cells. | 26130514 |
| Pterygium | Stem Cell Exhaustion | We describe a novel surgical technique for pterygium removal taking advantage of the properties of amniotic membrane and limbal epithelial stem cells. | 26130669 |
| Pterygium | Stem Cell Exhaustion | The minor ipsilateral simple limbal epithelial transplantation technique for the treatment of pterygium requires less tissue than the conventional conjunctival autograft, leaving healthy conjunctiva if needed for another procedure in the future and offers the advantages of epithelial stem cells, which in the long term may reduce the rate of recurrence significantly. | 26130669 |
| Toxic effect, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Reduced-intensity conditioning regimens have demonstrated lower toxicity but increased relapse rates in the context of allogeneic hematopoietic stem cell transplantation (aSCT) for patients with acute myelogenous leukemia (AML). | 26132980 |
| Neutropenia | Stem Cell Exhaustion | Fluoroquinolones are widely used for antibacterial prophylaxis during neutropenia following hematopoietic stem cell transplantation (HSCT). | 26134140 |
| Neoplasms | Stem Cell Exhaustion | Promoters of genes marked by polycomb in embryonic stem cells were methylated de novo in tumors and identified patients with poor prognosis. | 26134223 |
| Thrombasthenia | Stem Cell Exhaustion | Stem Cell Transplant in Severe Glanzmann Thrombasthenia in an Adult Patient. | 26134714 |
| Thrombasthenia | Stem Cell Exhaustion | A literature search showed 18 previously reported cases of Glanzmann thrombasthenia treated with allogeneic hematopoietic stem cell transplant. | 26134714 |
| Thrombasthenia | Stem Cell Exhaustion | We report an 18-year-old woman with severe Glanzmann thrombasthenia who was treated with allogeneic hematopoietic stem cell transplant from her sister. | 26134714 |
| Burn injury | Stem Cell Exhaustion | This process activated cell proliferation in the tissue and, interestingly, in the bulge region of the HF, a major reservoir of epidermal stem cells, promoting hair growth, as well as stimulating tissue repair after severe burn injury. | 26134949 |
| Loss of Chromosome 5q | Stem Cell Exhaustion | (1) for abnormalities of +8, 5q-/-5, 20q-/-20 or chromosome 7 involvements, clonal cells above the baseline level were detected in the pluripotent stem cell level. | 26135215 |
| Myelodysplastic Syndrome Clone | Stem Cell Exhaustion | It seems that the all malignant MDS clones originated at the pluripotent hematopoietic stem cell stage and that the proliferation and differentiation potencies were retained partly in these clonal cells. | 26135215 |
| Heart failure | Stem Cell Exhaustion | Allogeneic Mesenchymal Stem Cells Restore Endothelial Function in Heart Failure by Stimulating Endothelial Progenitor Cells. | 26137590 |
| Heart failure, Endothelial dysfunction | Stem Cell Exhaustion | Endothelial dysfunction, characterized by diminished endothelial progenitor cell (EPC) function and flow-mediated vasodilation (FMD), is a clinically significant feature of heart failure (HF). | 26137590 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | Cytomegalovirus infection induces a stem cell phenotype in human primary glioblastoma cells: prognostic significance and biological impact. | 26138445 |
| Glioblastoma Multiforme Pathway, Neoplasms | Stem Cell Exhaustion | Unfortunately, this standard therapy does not target glioma cancer stem cells (GCSCs), a subpopulation of GBM cells that can give rise to recurrent tumors. | 26138445 |
| Hematopoietic stem cells, T-Cell Lymphoma | Stem Cell Exhaustion | Infused autograft lymphocyte-to-monocyte ratio and survival in T-cell lymphoma post-autologous peripheral blood hematopoietic stem cell transplantation. | 26138828 |
| Lymphoma, Hemopoietic stem cell transplant | Stem Cell Exhaustion | The infused autograft lymphocyte-to-monocyte ratio (A-LMR) is a prognostic factor for survival in B-cell lymphomas post-autologous peripheral hematopoietic stem cell transplantation (APHSCT). | 26138828 |
| Multiple Myeloma | Stem Cell Exhaustion | High-dose melphalan with autologous stem cell support improves survival for patients with myeloma. | 26141214 |
| Multiple Myeloma | Stem Cell Exhaustion | Carefully selected patients receiving an autologous stem cell transplant for treatment of myeloma can be managed with a brief initial hospitalization and outpatient follow-up, with low morbidity and mortality. | 26141214 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Non-myeloablative allogeneic hematopoietic stem cell transplantation for adults with relapsed and refractory mantle cell lymphoma: a single-center analysis in the rituximab era. | 26146802 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation for poor-risk CLL: dissecting immune-modulating strategies for disease eradication and treatment of relapse. | 26146810 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | To elucidate factors contributing to the effectiveness of allogeneic hematopoietic stem cell transplantation (alloHCT) in high-risk CLL, immune interventions, GvHD and clinical outcome of 77 consecutive patients allografted for CLL were analyzed. | 26146810 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation in adults with myelodysplastic syndrome: Experience of the Argentinean Group of Bone Marrow Transplantation (GATMO). | 26147089 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (AHSCT) is a curative approach for patients with myelodysplastic syndrome (MDS). | 26147089 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Aldehyde dehydrogenase 1 (ALDH1) is widely used as a specific cancer stem cell marker in a variety of cancers, and may become a promising target for cancer therapy. | 26148881 |
| Ovarian Carcinoma, Malignant neoplasm of ovary, Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | High expression of cancer stem cell marker ALDH1 in ovarian carcinoma cells may thus portend a favorable prognosis, but its expression in tumor microenvironment may have no role in tumor behavior of ovarian carcinomas. | 26148881 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The importance of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for survival outcomes in patients with acute myeloid leukemia (AML) currently remains unclear. | 26149802 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Assessing the efficacy of allogeneic hematopoietic stem cells transplantation (allo-HSCT) by analyzing survival end points in defined groups of acute myeloid leukemia patients: a retrospective, multicenter Polish Adult Leukemia Group study. | 26149802 |
| F9 wt Allele | Stem Cell Exhaustion | Moreover, PTC spheres express higher levels of stem cell markers and lower levels of thyroid-specific genes compared with NT spheres. | 26151334 |
| Thyroid carcinoma, Specialty Type - cancer, Malignant Neoplasms, Malignant neoplasm of thyroid | Stem Cell Exhaustion | Cancer stem cells from several human malignancies, including poorly differentiated thyroid carcinoma and thyroid cancer cell lines, have been cultured in vitro as sphere-forming cells. | 26151334 |
| Neoplasms, Malignant neoplasm of thyroid | Stem Cell Exhaustion | These thyroid cancer stem cells were proven to be able to reproduce the original tumor in a xenograft orthotopic model. | 26151334 |
| Hematologic Neoplasms, Neoplasms | Stem Cell Exhaustion | Survival at 90 days post diagnosis was 71.4% in the solid tumour cohort, 62.5% in patients with solid organ transplants, 43.5% in haematological malignancy (HMs) and 37% in those undergoing allogeneic haematopoietic stem cell transplantation (HSCT). | 26152371 |
| Alzheimers Disease | Stem Cell Exhaustion | GDF-15 secreted from human umbilical cord blood mesenchymal stem cells delivered through the cerebrospinal fluid promotes hippocampal neurogenesis and synaptic activity in an Alzheimer's disease model. | 26154268 |
| Up, "Alzheimers Disease | Stem Cell Exhaustion | Our previous studies demonstrated that transplantation of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) into the hippocampus of a transgenic mouse model of Alzheimer's disease (AD) reduced amyloid-b (Ab) plaques and enhanced cognitive function through paracrine action. | 26154268 |
| Hematologic Neoplasms, Fungemia | Stem Cell Exhaustion | So, we report our 6-year surveillance study of fungaemia among patients with haematological malignancies and haematopoietic stem cell transplant. | 26155743 |
| Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | ATII cells acting as multifunctional stem cells might transform into NSCLC after undergoing exogenous or endogenous factors. | 26156586 |
| Usual Severity Pain | Stem Cell Exhaustion | Total and rate of pain reduction were linked to mesenchymal stem cell concentration through 12 months. | 26156727 |
| precancerous lesions, Malignant neoplasm of esophagus | Stem Cell Exhaustion | In this study, we investigated CA9 expression in esophageal cancers and in precancerous lesions and explored the association of CA9 expression with prognostic factors and with stem cell and tumorigenesis-related markers including BMI1, cyclin E, ki67, MCM4 and MCM7 expression. | 26156831 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | We recently demonstrated that epicardial progenitor cells participate in the regenerative response to myocardial infarction (MI) and factors released in the pericardial fluid (PF) may play a key role in this process. | 26159041 |
| Antilymphocyte Serum | Stem Cell Exhaustion | The ability of hUCB plasma to modulate the mitogen cell response and reduce caspase activity suggests that the use of hUCB plasma alone, or with stem cells, may prove useful as a therapeutic in ALS patients. | 26159164 |
| Celiac Disease | Stem Cell Exhaustion | Circulating hematopoietic stem cells and putative intestinal stem cells in coeliac disease. | 26160352 |
| Celiac Disease | Stem Cell Exhaustion | The intestinal stem cells (ISC) modulation and the role of circulating hematopoietic stem cells (HSC) in coeliac disease (CD) are poorly understood. | 26160352 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Aldehyde dehydrogenase 1A1 (ALDH1A1) is considered to be a cancer stem cell marker in several human malignancies. | 26160842 |
| Specialty Type - cancer, Hollings Cancer Center | Stem Cell Exhaustion | In this study, we investigated the relationship between ALDH1A1 and clinicopathological findings and examined whether ALDH1A1 deserves to be a cancer stem cell marker in HCC. | 26160842 |
| Specialty Type - cancer, Hollings Cancer Center | Stem Cell Exhaustion | In double-staining IHC, ALDH1A1 was not co-expressed with BMI1, EpCAM, CD13, CD24, CD90 and CD133, which reported as cancer stem cell markers in HCC. | 26160842 |
| Specialty Type - cancer, Hollings Cancer Center | Stem Cell Exhaustion | In conclusion, ALDH1A1-overexpressing cells could appear to be differentiated cells rather than cancer stem cells in HCC. | 26160842 |
| Liver carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | ALDH1A1-overexpressing cells are differentiated cells but not cancer stem or progenitor cells in human hepatocellular carcinoma. | 26160842 |
| Acute myocardial infarction | Stem Cell Exhaustion | Intracoronary infusion of Wharton's jelly-derived mesenchymal stem cells in acute myocardial infarction: double-blind, randomized controlled trial. | 26162993 |
| Malignant Peripheral Nerve Sheath Tumor, Myeloproliferative disease | Stem Cell Exhaustion | Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by proliferation of one or more myeloid lineages. | 26163633 |
| Ulcer | Stem Cell Exhaustion | The implementation of mesenchymal stem cell techniques for treatment of chronic ulcer is feasible. | 26164137 |
| Diabetes Mellitus, Ulcer | Stem Cell Exhaustion | [Autologous mesenchymal stem cells and cutaneus autograft as a treatment for chronic ulcer secondary to diabetes mellitus 2]. | 26164137 |
| Ulcer | Stem Cell Exhaustion | Mesenchymal stem cells have emerged as a promising cell source for the treatment of these ulcers. | 26164137 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Biodistribution of 18F-FDG-Labeled Autologous Bone Marrow-Derived Stem Cells in Patients With Type 2 Diabetes Mellitus: Exploring Targeted and Intravenous Routes of Delivery. | 26164170 |
| diabetic | Stem Cell Exhaustion | The study aims to carry out in vivo tracking of stem cells labeled with positron emission tomography (PET) tracer fluorine 18-fluorodeoxyglucose (F-FDG) and find adequate administration methods for these cells in diabetic patients. | 26164170 |
| Diabetes Mellitus | Stem Cell Exhaustion | The labeled stem cells were given in a total of 21 type 2 diabetes mellitus patients comprising 3 groups of 7 patients each. | 26164170 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft versus host disease (GvHD) is a clinically important complication after allogeneic hematopoietic stem cell transplantation (HSCT). | 26164839 |
| Mixed Salivary Gland Tumor, Carcinoma | Stem Cell Exhaustion | The Stem Cell Marker Bmi-1 Is Sensitive in Identifying Early Lesions of Carcinoma ex Pleomorphic Adenoma. | 26166073 |
| Mixed Salivary Gland Tumor, Carcinoma | Stem Cell Exhaustion | In the present study, we evaluated and described the sensitivity of the stem cell marker B cell-specific moloney murine leukemia virus integration site 1 (Bmi-1) in identifying early lesions of carcinoma ex pleomorphic adenoma (CXPA). | 26166073 |
| Toxic effect | Stem Cell Exhaustion | BEAM Conditioning Regimen Has Higher Toxicity Compared With High-Dose Melphalan for Salvage Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma. | 26166312 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Salvage autologous stem cell transplantation (ASCT) is increasingly used for eligible patients with multiple myeloma (MM) for progress after conventional chemotherapy. | 26166312 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Favorable survival after allogeneic stem cell transplantation with reduced-intensity conditioning regimens for relapsed/refractory follicular lymphoma. | 26168068 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Allogeneic stem cell transplantation (allo-SCT) is a curative option for patients with relapsed follicular lymphoma (FL). | 26168068 |
| Triple-Negative Breast Cancer Finding, Childhood Breast Carcinoma | Stem Cell Exhaustion | Triple-negative breast cancer (TNBC) is a heterogeneous group of disease with a well-known association with epithelial-mesenchymal transition (EMT) and breast cancer stem cell phenotype. | 26170011 |
| Childhood Breast Carcinoma, Neoplasms | Stem Cell Exhaustion | We analyzed immunohistochemical expression of EMT-related markers, including EMT markers (expression of vimentin, smooth muscle actin, osteonectin, and N-cadherin; loss of E-cadherin), EMT inducers (ZEB1 and CD146), and breast cancer stem cell markers (CD44(+)/CD24(-) and aldehyde dehydrogenase 1) in 173 TNBCs and correlated their expression with clinicopathological features of the tumors, including clinical outcome. | 26170011 |
| Malignant neoplasm of liver | Stem Cell Exhaustion | LncRNA HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2. | 26172293 |
| Malignant neoplasm of liver | Stem Cell Exhaustion | Herein, we demonstrate HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2. | 26172293 |
| Malignant neoplasm of liver | Stem Cell Exhaustion | This study provides evidence for HOTAIR to promote tumorigenesis via downregulating SETD2 in liver cancer stem cells. | 26172293 |
| Malignant neoplasm of urinary bladder | Stem Cell Exhaustion | Together these findings implicate variants in the Wnt/b-catenin stem cell pathway as having a role in bladder cancer etiology. | 26173102 |
| Mobilized Peripheral Blood Stem Cell, Multiple Myeloma | Stem Cell Exhaustion | Comparison of biosimilar filgrastim with originator filgrastim for peripheral blood stem cell mobilization and engraftment in patients with multiple myeloma undergoing autologous stem cell transplantation. | 26173921 |
| Wernicke-Korsakoff Syndrome, Central neuroblastoma | Stem Cell Exhaustion | Stem Cell Transplant-Associated Wernicke Encephalopathy in a Patient with High-Risk Neuroblastoma. | 26174546 |
| Cerebellar Ataxia, Central neuroblastoma, Tachycardia by ECG Finding | Stem Cell Exhaustion | We present the case of a 5-year-old patient with stage 4, high-risk neuroblastoma who developed altered mental status, ataxia, and tachycardia during consolidative autologous stem cell transplantation. | 26174546 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Stem cell biomarker ALDH1A1 in breast cancer shows an association with prognosis and clinicopathological variables that is highly cut-off dependent. | 26175266 |
| Childhood Breast Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Aldehyde dehydrogenase family 1 member A1 (ALDH1A1) is a putative marker of breast cancer stem cells (CSCs) with prognostic implications when expressed in cancer or stroma. | 26175266 |
| Gallbladder adenocarcinoma | Stem Cell Exhaustion | Prognostic Value of the Stem Cell Markers Epcam and CD133 Expression Of Gallbladder Adenocarcinoma. | 26176038 |
| Malignant Lesion | Stem Cell Exhaustion | To investigate the expressions and prognostic value of stem cell markers, EpCAM and CD133, in benign and malignant lesions of gallbladder. | 26176038 |
| HIV Infections | Stem Cell Exhaustion | Proliferation of neural progenitor cells in the dentate gyrus was increased in HIV infection (P = 0.028), whereas the density of recently generated TUC-4 [TOAD (turned on after division)/Ulip/CRMP family 4]-expressing neurons in this region was not significantly elevated in HIV-infected cases (P = 0.13). | 26176591 |
| Heart failure | Stem Cell Exhaustion | Current interventions range from conservative heart failure management to autologous stem cell and heart transplantation. | 26177555 |
| Diarrhea | Stem Cell Exhaustion | Colonoscopy and Sigmoidoscopy are Equally Effective for the Diagnosis of Colonic Acute Graft-versus-Host Disease in Patients with Diarrhea after Allogeneic Stem Cell Transplantation: A Prospective Controlled Trial. | 26183080 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Colonic acute graft-versus-host disease (aGVHD) affects approximately 10% of patients who have undergone allogeneic stem cell transplantation (allo-SCT). | 26183080 |
| Cessation of life, Scleroderma Renal Crisis, Malignant Neoplasms, Purpura, Thrombotic Thrombocytopenic | Stem Cell Exhaustion | After excluding deaths from scleroderma renal crisis (100% mortality), malignancy (75% mortality) and stem cell transplant (50% mortality), the survival rate for secondary TTP was 85%. | 26183258 |
| Neoplasms | Stem Cell Exhaustion | On the other hand, all tumor cells were positive for CD133, Musashi1, and SOX-2 which are the markers of neural stem cells. | 26183264 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | These results also indicated that pluripotential cancer stem cells differentiated into glial and muscle cell lines at the time of tumor growth. | 26183264 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The application of allogeneic stem cell transplantation increased over time among AML patients up to age 70 years. | 26183645 |
| Hemoglobinuria, CTCAE 3.0, Multiple Myeloma | Stem Cell Exhaustion | Significance of the detection of paroxysmal nocturnal hemoglobinuria clones in patients with multiple myeloma undergoing autologous stem cell transplantation. | 26183672 |
| Central nervous system complication | Stem Cell Exhaustion | Central nervous system complications (CNSC) can be the cause of morbidity and mortality in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 26184063 |
| SERPINB3 wt Allele, Specialty Type - cancer | Stem Cell Exhaustion | Silencing shJARID1B significantly inhibited oral cancer stem cell activity and potentiated the tumor-inhibitory activity of radiation therapy in OSCC. | 26184998 |
| SERPINB3 wt Allele, Specialty Type - cancer | Stem Cell Exhaustion | Silencing shJARID1B inhibits migration and invasion of human OSCC, reduces cancer stem cell activities and potentiates tumor-inhibiting radiotherapeutic effects. | 26184998 |
| Specialty Type - cancer | Stem Cell Exhaustion | Each line mainly included EpCAM-positive cells and cells expressing putative cancer stem cell markers such as CD133, CD44, CD24, ALDH1, and LGR5. | 26185002 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Cytoplasmic expression of RBMY, which is mediated by binding to nuclear exporter chromosome region maintenance 1 and further enriched upon Wnt-3a stimulation, confers upon tumor cells the traits of cancer stem cell by augmenting self-renewal, chemoresistance, cell-cycle progression, proliferation, and xenograft tumor growth. | 26185016 |
| Hollings Cancer Center, Malignant neoplasm of liver, Hepatocarcinogenesis | Stem Cell Exhaustion | Upon hepatocarcinogenesis, a noteworthy increase of cytoplasmic and nuclear RBMY is observed in HCC tissues; however, only the former is expressed dominantly in hepatic cancer stem cells and correlates significantly to a poor prognosis and decreased survival rate in HCC patients. | 26185016 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | The purpose of our study is to determine the outcome of patients with systemic non-Hodgkin lymphoma presenting with neurologic localization at diagnosis, as well as the impact of consolidation in terms of high-dose therapy followed by autologous stem cell transplantation. | 26185174 |
| Malignant Neoplasms | Stem Cell Exhaustion | Stem cells, aging and cancers. | 26186894 |
| Neoplasms | Stem Cell Exhaustion | Whether these two neoplasms were related is unclear; however, if so, we suspect the combination might be caused by a malignant transformation of a promonocyte or stem cell, upstream of histiocytes and monocytes. | 26187047 |
| Ki-1+ Anaplastic Large Cell Lymphoma | Stem Cell Exhaustion | A non-NPM1 fusion partner of ALK was identified in a 32-year-old Caucasian male ALCL patient whose disease was refractory to standard chemotherapy and autologous stem cell transplantation, and exhibited a poor response to a first-generation ALK inhibitor. | 26187744 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | CD34-Selected Hematopoietic Stem Cell Transplants Conditioned with Myeloablative Regimens and Antithymocyte Globulin for Advanced Myelodysplastic Syndrome: Limited Graft-versus-Host Disease without Increased Relapse. | 26187863 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only curative therapy for patients with myelodysplastic syndrome (MDS). | 26187863 |
| Memory impairment | Stem Cell Exhaustion | Wharton's Jelly-derived mesenchymal stem cells alleviate memory deficits and reduce amyloid-b deposition in an APP/PS1 transgenic mouse model. | 26188488 |
| nervous system disorder | Stem Cell Exhaustion | Wharton's Jelly-derived mesenchymal stem cells (WJ-MSCs) have a potential therapeutic effect in the treatment for neurological diseases. | 26188488 |
| Liver carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | MiR-491 attenuates cancer stem cells-like properties of hepatocellular carcinoma by inhibition of GIT-1/NF-kB-mediated EMT. | 26188902 |
| Multiple Myeloma | Stem Cell Exhaustion | Efficacy of biosimilar granulocyte colony-stimulating factor versus originator granulocyte colony-stimulating factor in peripheral blood stem cell mobilization in de novo multiple myeloma patients. | 26188967 |
| Mobilized Peripheral Blood Stem Cell | Stem Cell Exhaustion | Filgrastim and lenograstim are the standard granulocyte colony-stimulating factor (G-CSF) agents for peripheral blood stem cell mobilization (PBSC) in patients who undergo autologous stem cell transplantation. | 26188967 |
| Gastrointestinal mucositis, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | An oral care self-management support protocol (OrCaSS) to reduce oral mucositis in hospitalized patients with acute myeloid leukemia and allogeneic hematopoietic stem cell transplantation: a randomized controlled pilot study. | 26190359 |
| Gastrointestinal mucositis, Oman | Stem Cell Exhaustion | Oral mucositis (OM) is a common and debilitating side effect of chemoradiotherapy in patients awaiting allogeneic hematopoietic stem cell transplantation (aHSCT). | 26190359 |
| Multiple Myeloma | Stem Cell Exhaustion | Clinical features and survival of 338 multiple myeloma patients treated with hematopoietic stem cell transplantation or conventional chemotherapy. | 26190662 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Musashi-1, a RNA-binding protein, is suggested to be a cancer stem cell-related marker; its high level of protein expression is reported to be associated with high histological grade in some tumors. | 26191146 |
| Specialty Type - cancer | Stem Cell Exhaustion | Furthermore, we examined whether Musashi-1 expression is correlated with another cancer stem cell marker CD133 by real-time RT-PCR. | 26191146 |
| Colonic Neoplasms | Stem Cell Exhaustion | Occurrence of colon tumors in a 16-year-old Japanese boy after hematopoietic stem cell transplantation for Diamond Blackfan anemia at age of 4: a case report. | 26191323 |
| Colonic Neoplasms | Stem Cell Exhaustion | Here, we report a case of a 16-year-old Japanese boy suffering from multiple colon tumors during the follow-up after hematopoietic stem cell transplantation for DBA at the age of 4. | 26191323 |
| Pulmonary arterial hypertension | Stem Cell Exhaustion | Endothelial NO-Synthase Gene-Enhanced Progenitor Cell Therapy for Pulmonary Arterial Hypertension: The PHACeT Trial. | 26195220 |
| Pulmonary Hypertension | Stem Cell Exhaustion | The Pulmonary Hypertension and Angiogenic Cell Therapy (PHACeT) trial was a phase 1, dose-escalating clinical study of the tolerability of culture-derived endothelial progenitor cells, transiently transfected with endothelial nitric oxide synthase, in patients with PAH refractory to PAH-specific therapies. | 26195220 |
| Dental Pulp Necrosis | Stem Cell Exhaustion | Regenerative endodontic procedures are stem cell-based treatments for immature teeth with pulp necrosis. | 26195498 |
| Specialty Type - cancer | Stem Cell Exhaustion | Also, bigger mammals with larger underlying stem cell pools are not proportionally more prone to cancer, an observation known as Peto's paradox. | 26195756 |
| Inflammation | Stem Cell Exhaustion | Phenotypic enumeration of colonocytes' subcompartments from patients revealed significant alterations of the lower crypt, enriched in stem cell and progenitors, independent of inflammation. | 26197452 |
| Inflammation, Ulcerative Colitis | Stem Cell Exhaustion | Our results thus provide new insights into the development of inflammation and relapse in UC and suggest that the stem cell niche in the colon may influence pathogenesis of the disease. | 26197452 |
| Neoplasms | Stem Cell Exhaustion | Bevacizumab/high-dose chemotherapy with autologous stem-cell transplant for poor-risk relapsed or refractory germ-cell tumors. | 26199392 |
| Multiple Myeloma, Communicable Diseases | Stem Cell Exhaustion | Incidence of infection according to intravenous immunoglobulin use in autologous hematopoietic stem cell transplant recipients with multiple myeloma. | 26201517 |
| Stable chronic Graft vs Host Disease | Stem Cell Exhaustion | Chronic graft versus host disease (cGvHD) is the most common cause of late morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). | 26204824 |
| Chronic total occlusion of coronary artery | Stem Cell Exhaustion | We have evaluated the safety and efficacy of intracoronary human umbilical cord-derived mesenchymal stem cell (hUCMSC) treatment for very old patients with coronary chronic total occlusion. | 26205288 |
| Crohn Disease | Stem Cell Exhaustion | Ex vivo immunosuppressive effects of mesenchymal stem cells on Crohn's disease mucosal T cells are largely dependent on indoleamine 2,3-dioxygenase activity and cell-cell contact. | 26206376 |
| Spinal Cord Injuries | Stem Cell Exhaustion | Intrathecal transplantation of autologous adipose-derived mesenchymal stem cells for treating spinal cord injury: A human trial. | 26208177 |
| Neoplasms | Stem Cell Exhaustion | Maspin-nonexpressing tumor cells that survived the suspension culture in compact tumorspheres displayed a higher level of stem cell marker expression, maintained the self-renewal capacity, formed tumorspheres in 3D matrices in vitro, and were tumorigenic in vivo. | 26208903 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | We investigated the effects of sitagliptin, a dipeptidyl peptidase (DPP)-4 inhibitor, on the number of circulating CD34(+)CXCR4(+)cells, a candidate for endothelial progenitor cells (EPCs), plasma levels of stromal cell-derived factor (SDF)-1a, a ligand for CXCR4 receptor and a substrate for DPP-4, and plasma levels of interferon-inducible protein (IP)-10, for a substrate for DPP-4, in patients with type 2 diabetes. | 26209038 |
| Antilymphocyte Serum | Stem Cell Exhaustion | Previously, we reported that human bone marrow mesenchymal stromal cells isolated from ALS patients (ALS-MSCs) have functionally decreased stem cell potency, and excessively express DNA methyltransferases (DNMTs). | 26210997 |
| SERPINB3 wt Allele, Squamous cell carcinoma, Stable chronic Graft vs Host Disease, Neoplasms, Graft-vs-Host Disease | Stem Cell Exhaustion | Oral squamous cell carcinoma (OSCC) is one of the most common solid tumours occurring after haematopoietic stem cell transplantation (HSCT), especially in patients with chronic graft-versus-host-disease (cGVHD). | 26211810 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Cytomegalovirus Reactivation after Allogeneic Hematopoietic Stem Cell Transplantation is Associated with a Reduced Risk of Relapse in Patients with Acute Myeloid Leukemia Who Survived to Day 100 after Transplantation: The Japan Society for Hematopoietic Cell Transplantation Transplantation-related Complication Working Group. | 26211985 |
| Clostridium difficile | Stem Cell Exhaustion | Clostridium Difficile Colonization in Hematopoietic Stem Cell Transplant Recipients: A Prospective Study of the Epidemiology and Outcomes Involving Toxigenic and Nontoxigenic Strains. | 26211988 |
| Clostridium difficile, Dysentery | Stem Cell Exhaustion | Clostridium difficile is a leading cause of infectious diarrhea in hematopoietic stem cell transplant (HSCT) recipients. | 26211988 |
| Hollings Cancer Center | Stem Cell Exhaustion | Using HCC cell lines, we then demonstrated that either TACC3 knockdown or treatment with the potential TACC3 inhibitor KHS101 suppressed cell growth and sphere formation as well as the expression of stem cell transcription factors, including Bmi1, c-Myc and Nanog. | 26219398 |
| Specialty Type - cancer | Stem Cell Exhaustion | Silencing TACC3 may suppress the Wnt/b-catenin and PI3K/AKT signaling pathways, which regulate cancer stem cell-like characteristics. | 26219398 |
| Hollings Cancer Center, Specialty Type - cancer | Stem Cell Exhaustion | Taken together, these data suggest that TACC3 is enriched in HCC and that TACC3 down-regulation inhibits the proliferation, clonogenicity, and cancer stem cell-like phenotype of HCC cells. | 26219398 |
| Adenoma, Pituitary Adenoma | Stem Cell Exhaustion | The present study aimed at the evaluation of Hh signaling in relation to stem cell and cell cycle markers in 30 human pituitary adenomas and in cultured murine adenoma cells. | 26219678 |
| Pituitary Adenoma | Stem Cell Exhaustion | Therefore, expression levels of components of the Hh pathway, stem cell marker SOX2, cell cycle regulator tumor-protein 53 (TP53), proliferation marker Ki67 (MKI67) and superoxide dismutase 1 (SOD1) were evaluated in 30 human pituitary adenomas in comparison to control tissue. | 26219678 |
| Specialty Type - cancer | Stem Cell Exhaustion | It was found to be aberrantly activated in numerous types of human cancer and might be relevant in cancer stem cells. | 26219678 |
| Pituitary Adenoma | Stem Cell Exhaustion | The identification of adult stem cells in the pituitary raised the question if tumor-initiating cells and Hh signaling are involved in pituitary adenoma formation. | 26219678 |
| Osteoporosis | Stem Cell Exhaustion | Therefore, it was the aim of the present study to investigate the dynamics of haemopoietic stem cells and corresponding in peripheral blood of 13 patients with osteoporosis during treatment with teriparatide. | 26220030 |
| Blood Circulation | Stem Cell Exhaustion | We were able to show that administration of teriparatide is sufficient to mobilise haemopoietic stem cells into the bloodstream accompanied by an alteration of mobilising cytokines. | 26220030 |
| Liver carcinoma | Stem Cell Exhaustion | Progenitor cell markers predict outcome of patients with hepatocellular carcinoma beyond Milan criteria undergoing liver transplantation. | 26220754 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation could improve survival of cytogenetically normal adult acute myeloid leukemia patients with DNMT3A mutations. | 26223865 |
| Cytogenetically normal acute myeloid leukemia | Stem Cell Exhaustion | The role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in DNMT3A(mut) cn-AML patients remains unclear. | 26223865 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Resveratrol-downregulated phosphorylated liver kinase B1 is involved in senescence of acute myeloid leukemia stem cells. | 26223914 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The aim of this study was to examine the effect of resveratrol-downregulated phosphorylated liver kinase B1 (pLKB1) on the senescence of acute myeloid leukemia (AML) stem cells. | 26223914 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | It was concluded that resveratrol-downregulated pLKB1 is involved in the senescence of AML stem cells. | 26223914 |
| Muscular Atrophy | Stem Cell Exhaustion | Induced pluripotent stem cells (iPSCs) are a promising tool for regenerative medicine in chronic conditions associated with muscle atrophy since iPSCs are easier to obtain, pose less ethical limitations and can better capture human genetic diversity compared with human embryonic stem cells. | 26224204 |
| Dental Plaque | Stem Cell Exhaustion | As cardiovascular mortality relates to plaque instability, which depends on the integrity of the fibrous cap, we hypothesize that the inhibition of the potential of mesenchymal stem cells (MSCs) to differentiate into macrophages would help to explain the long known, but less understood "non-lipid-associated" or pleiotropic benefit of statins on cardiovascular mortality. | 26224580 |
| Chronic myeloproliferative disorder, Mastocytosis | Stem Cell Exhaustion | Chronic myeloproliferative diseases are clonal stem cell diseases which occur as a result of uncontrollable growth and reproduction of hematopoietic stem cells, which are the myeloid series source in bone marrow. | 26225646 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Human herpesvirus-6 (HHV-6) is known to reactivate after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and may be associated with development of acute graft-versus-host disease (GVHD) and nonrelapse mortality (NRM). | 26226409 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | We found that miR-320a expression was reduced in K562 and in CML cancer stem cells. | 26228085 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | Regimens for acute lymphoblastic leukemia can be used for management of secondary acute lymphoblastic leukemia with plan for stem cell transplantation. | 26228379 |
| TSPYL2 gene, Lymphoma, T-Cell, Cutaneous | Stem Cell Exhaustion | Early-stage cutaneous T-cell lymphoma (CTCL) is a skin-limited lymphoma with no cure aside from stem cell transplantation. | 26228486 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplantation (ASCT) is the standard of care for selected patients with multiple myeloma (MM). | 26228581 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey. | 26228813 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | PD-1(hi)TIM-3(+) T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation. | 26230954 |
| leukemia | Stem Cell Exhaustion | Prognosis of leukemia relapse post allogeneic stem cell transplantation (alloSCT) is poor and effective new treatments are urgently needed. | 26230954 |
| Angioma, Cavernous, Cerebrovascular accident | Stem Cell Exhaustion | While cavernous angioma (CVA) after cranial irradiation has been documented, its development after high-dose chemotherapy with autologous peripheral blood stem cell transplantation (PBSCT) has not. | 26231569 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | USP44+ Cancer Stem Cell Subclones Contribute to Breast Cancer Aggressiveness by Promoting Vasculogenic Mimicry. | 26232424 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | In our previous study, breast cancer stem cells (CSC) were shown to potentially participate in VM formation. | 26232424 |
| Autoimmune sensorineural hearing loss | Stem Cell Exhaustion | The paracrine effect of mesenchymal human stem cells restored hearing in b-tubulin induced autoimmune sensorineural hearing loss. | 26235980 |
| Autoimmune reaction | Stem Cell Exhaustion | The aim of this study was to examine the activities of hASCs (Human Adipose tissue Derived Stem Cells) on experimental autoimmune hearing loss (EAHL) and how human stem cells regenerated mouse cochlea cells. | 26235980 |
| Autoimmune reaction | Stem Cell Exhaustion | We have restored hearing in 19 years old white female with autoimmune hearing loss with autologous adipose tissue derived stem cells and we wish to understand the mechanism of restoration of hearing in animal model. | 26235980 |
| Stria Vascularis | Stem Cell Exhaustion | In control group, without receiving stem cells, the organ of Corti is replaced by a single layer of cells, atrophy of stria vascularis. | 26235980 |
| Primary Myelofibrosis | Stem Cell Exhaustion | In myelofibrosis, the introduction of reduced-intensity conditioning (RIC) preceding allogeneic stem cell transplantation (SCT) resulted in lower transplant-related mortality rates compared with myeloablative conditioning. | 26237165 |
| Malignant Neoplasms | Stem Cell Exhaustion | Fludarabine and treosulfan compared with other reduced-intensity conditioning regimens for allogeneic stem cell transplantation in patients with lymphoid malignancies. | 26237166 |
| Malignant Neoplasms | Stem Cell Exhaustion | Allogeneic stem-cell transplantation (SCT) is a potentially curative therapy for lymphoid malignancies. | 26237166 |
| Viral Encephalitis | Stem Cell Exhaustion | Viral reactivation following hematopoietic stem cell transplantation (HSCT) can cause various complications especially viral encephalitis. | 26241219 |
| Meningioma | Stem Cell Exhaustion | Expression of Stem Cell Marker Nestin and MicroRNA-21 in Meningiomas. | 26242334 |
| Specialty Type - cancer | Stem Cell Exhaustion | Leukapheresis is often performed in cancer patients to harvest stem cells, manufacture therapeutic vaccines, or follow immunologic response to therapy. | 26243387 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | A cohort of 110 cases of simultaneous UGI and LGI biopsies from 105 allogeneic hematopoietic stem cell transplantation recipients with clinically confirmed GI GVHD were reviewed retrospectively. | 26243672 |
| Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8 | Stem Cell Exhaustion | Disease modeling of induced pluripotent stem cells (iPSCs) from patients with longstanding T1D (disease duration >= 50 years) with severe (Medalist +C) or absent to mild complications (Medalist -C) revealed impaired growth, reprogramming, and differentiation in Medalist +C. | 26244933 |
| Malignant neoplasm of lung, Specialty Type - cancer | Stem Cell Exhaustion | Tyr1068-phosphorylated epidermal growth factor receptor (EGFR) predicts cancer stem cell targeting by erlotinib in preclinical models of wild-type EGFR lung cancer. | 26247735 |
| Malignant neoplasm of lung | Stem Cell Exhaustion | Therapeutics validation has necessarily to focus on lung cancer stem cells (LCSCs) as they are more difficult to eradicate and represent the tumor-maintaining cell population. | 26247735 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Mammosphere formation was used to assess breast cancer stem cell properties. | 26248960 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | [Hypofibrinogenemia associated with steroid therapy for the patients who developed GVHD after allogeneic stem cell transplantation]. | 26251153 |
| Disseminated neuroblastoma, Central neuroblastoma | Stem Cell Exhaustion | However, determining the duration of 13-cis-RA treatment for residual and recurrent neuroblastoma can be a problem because it is difficult to evaluate the effectiveness of the treatment.We performed 13-cis-RA treatment to remove residual active neuroblastoma cells in an 8-year-old boy with stage 4 neuroblastoma that developed from a left sympathetic ganglion and had been treated with chemotherapy, surgery, autologous peripheral blood stem-cell transplantation, and radiotherapy. | 26252303 |
| Amyloidosis | Stem Cell Exhaustion | Higher Stem Cell Dose Infusion after Intensive Chemotherapy Does Not Improve Symptom Burden in Older Patients with Multiple Myeloma and Amyloidosis. | 26253006 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma, Amyloidosis | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplantation (ASCT) for multiple myeloma (MM) is associated with high symptom burden, particularly for older patients and those with amyloid light-chain (AL) amyloidosis. | 26253006 |
| Specialty Type - cancer, Carcinoma, Transitional Cell | Stem Cell Exhaustion | Cancer stem cell theory plays an important role in the clinical study of transitional cell carcinoma of the upper urinary tract. | 26254374 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Radiosensitivity of Patient-Derived Glioma Stem Cell 3-Dimensional Cultures to Photon, Proton, and Carbon Irradiation. | 26254681 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | To investigate the radiosensitivity of primary glioma stem cell (GSC) cultures with different CD133 status in a 3-dimensional (3D) model after photon versus proton versus carbon irradiation. | 26254681 |
| Vancomycin-Resistant Enterococci, Colonization, Communicable Diseases | Stem Cell Exhaustion | Although several studies have documented adverse outcomes for vancomycin-resistant Enterococcus (VRE) colonization and infection in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients, data are inadequate for patients undergoing autologous (auto-)HSCT. | 26256692 |
| Thrombocytosis, Myeloproliferative disease, Primary Myelofibrosis, Malignant Peripheral Nerve Sheath Tumor, Polycythemia Vera, Neoplasms | Stem Cell Exhaustion | Myeloproliferative neoplasms (MPNs) are heterogeneous clonal bone marrow stem cell disorders and include polycythemia vera (PV), essential thrombocythemia (ET), and idiopathic myelofibrosis (IMF) neoplasia. | 26256826 |
| T-Cell Lymphoma | Stem Cell Exhaustion | Tet2 mutations induce enhanced self-renewal ability and competitive repopulation capacity in hematopoietic stem cells, and various MPN/MDS-like diseases and T-cell lymphoma consequently develop in model mice. | 26256875 |
| Hematologic Neoplasms | Stem Cell Exhaustion | In conclusion, TET2 might play a major role as a gate keeper for hematopoietic stem/progenitor cells preventing them from developing into various hematologic malignancies by acquiring additional disease-specific gene mutations. | 26256875 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Management of Myelodysplastic Syndrome Relapsing after Allogeneic Hematopoietic Stem Cell Transplantation: A Study by the French Society of Bone Marrow Transplantation and Cell Therapies. | 26256942 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | To find out prognostic factors and to investigate different therapeutic approaches, we report on 147 consecutive patients who relapsed after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for myelodysplastic syndrome (MDS). | 26256942 |
| Adult Glioblastoma, Specialty Type - cancer | Stem Cell Exhaustion | Hypoxia-mediated cancer stem cells in pseudopalisades with activation of hypoxia-inducible factor-1a/Akt axis in glioblastoma. | 26256949 |
| Specialty Type - cancer | Stem Cell Exhaustion | Hypoxic regions have been proposed as one of several distinct niches for cancer stem cells (CSCs) in GBM, but little is known about the association between Ps features and CSC properties. | 26256949 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Nonmyeloablative allogeneic stem cell transplantation for chronic lymphocytic leukaemia offers the possibility of disease control with minimal morbidity and mortality--a single institution experience. | 26259502 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Allogeneic stem cell transplantation is a treatment option for patients with poor risk CLL. | 26259502 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Our single-centre experience confirms the valuable role of allogeneic stem cell transplantation (allo-SCT) in the treatment of poor risk CLL patients with promising long-term survival and acceptable transplant-related mortality. | 26259502 |
| Acute Myeloid Leukemia with FLT3/ITD Mutation | Stem Cell Exhaustion | High rate of hematological responses to sorafenib in FLT3-ITD acute myeloid leukemia relapsed after allogeneic hematopoietic stem cell transplantation. | 26260140 |
| Allogeneic Hematopoietic Stem Cell Transplantation, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Relapse represents the most significant cause of failure of allogeneic hematopoietic stem cell transplantation (HSCT) for FLT3-ITD-positive acute myeloid leukemia (AML), and available therapies are largely unsatisfactory. | 26260140 |
| Palmar-plantar erythrodysesthesia syndrome, Cytopenia | Stem Cell Exhaustion | Treatment was overall manageable in the outpatient setting, although all patients experienced significant adverse events, especially severe cytopenias (requiring a donor stem cell boost in five patients) and typical hand-foot syndrome. | 26260140 |
| Communicable Diseases | Stem Cell Exhaustion | The relative contribution of human cytomegalovirus (HMCV)-specific CD4(+) and CD8(+) T cells to the control of HCMV infection in hematopoietic stem cell transplant (HSCT) recipients is still controversial. | 26260678 |
| MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute, Acute lymphocytic leukemia | Stem Cell Exhaustion | Phase II Trial of Reduced-Intensity Busulfan/Clofarabine Conditioning with Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Acute Myeloid Leukemia, Myelodysplastic Syndromes, and Acute Lymphoid Leukemia. | 26260679 |
| Acute leukemia | Stem Cell Exhaustion | Clofarabine has potent antileukemia activity and its inclusion in reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (HSCT) for acute leukemia could potentially improve outcomes. | 26260679 |
| PAFAH1B1 wt Allele, DiGeorge Syndrome | Stem Cell Exhaustion | A 4 year old child with MDS and DiGeorge Syndrome Type 2 was rescued with repetitive whole lung lavages and her PAP was cured with heterologous stem cell transplant. | 26264606 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Pretransplant platelet transfusion refractoriness is not associated with platelet nonengraftment in T-replete hematopoietic progenitor cell transplantation for hematologic malignancies. | 26264674 |
| Pancreatic carcinoma, Adenocarcinoma of pancreas | Stem Cell Exhaustion | We hypothesized that selected substances, participating in this "dialog," are associated with body mass and peripheral trafficking of bone marrow-derived stem cells (BMSCs) in both healthy individuals and patients with obesity-associated malignancies such as pancreatic adenocarcinoma.We performed an analysis of the systemic levels of selected substances involved in the regulation of bone (marrow) homeostasis (parathormone, calcitonin, osteopontin, osteonectin, stem cell factor [SCF], and fibroblast growth factor-23) in 35 generally healthy volunteers and 35 patients with pancreatic cancer. | 26266370 |
| Specialty Type - cancer | Stem Cell Exhaustion | While no significant correlation was observed between BMI and the number of circulating BMSCs in patients with cancer, peripheral trafficking of CD34 + KDR + CD31 + CD45-endothelial progenitor cells and CD105 + STRO-1 + CD45-mesenchymal stem cells was associated with the osteonectin/osteopontin ratio, which also correlated with BMI (r = 0.52; P < 0.05). | 26266370 |
| Stem Cell Factor | Stem Cell Exhaustion | Additionally, subcutaneous and visceral/omental AT levels of the aforementioned molecules were analyzed in lean and overweight/obese individuals.Intensified steady-state trafficking of only Lin-CD45 + CD133 + hematopoietic stem/progenitor cells was observed in overweight/obese individuals and this was associated with BMI values and elevated levels of both osteonectin and SCF, which also correlated with BMI. | 26266370 |
| Cessation of life, Lymphoma, Non-Hodgkin, Familial, Post-transplant lymphoproliferative disorder | Stem Cell Exhaustion | When death in the absence of HBV-RS was considered as the competing risk, the univariate and multivariate regression analyses showed that several factors were independently associated with the development of HBV-RS, including anti-HCV seronegativity, histological subtype of posttransplant lymphoproliferative disorders, >=6 cycles of rituximab therapy, and succeeding hematopoietic stem cell transplantation.The findings of our study identify additional factors influencing the development of rituximab-associated HBV-RS in HBsAg-seronegative adults with CD20 NHL. | 26266374 |
| BCR gene | Stem Cell Exhaustion | The results presented here highlight the need for mandatory inclusion of molecular testing for pediatric ALL patients in clinical decision making, together with the incorporation of tyrosine kinase inhibitors, as well as hematopoietic stem cell transplantation facilities, to improve treatment outcome for patients in developing countries. | 26266519 |
| Fecal Incontinence | Stem Cell Exhaustion | Implantation of autologous muscle-derived stem cells in treatment of fecal incontinence: results of an experimental pilot study. | 26266767 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | The influence of rituximab, high-dose therapy followed by autologous stem cell transplantation, and age in patients with primary CNS lymphoma. | 26268792 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | A case of 25-year-male presenting with leukemic BPDCN without cutaneous involvement is presented here, who was treated with AML like protocol followed by hematopoietic stem cell transplantation, but succumbed to the disease within 8 months of diagnosis. | 26275271 |
| Adult Glioblastoma | Stem Cell Exhaustion | Glioblastoma recurrence patterns near neural stem cell regions. | 26276527 |
| Specialty Type - cancer, Adult Glioblastoma, Neoplasms | Stem Cell Exhaustion | Glioblastoma (GBM) cancer stem cells and their neural stem cell counterparts are hypothesized to contribute to tumor progression. | 26276527 |
| Renal Insufficiency, Amyloidosis | Stem Cell Exhaustion | The prognostic factors associated with overall survival were the International Staging System, the serum lactate dehydrogenase level, the renal impairment, the realization of autologous stem cell transplantation, and the presence of concomitant amyloidosis. | 26277330 |
| Sepsis, EIF2AK3 wt Allele, Pneumonia | Stem Cell Exhaustion | Sepsis, stem cell transplantation, preexisting pneumonia, or the use of granulocyte colony-stimulating factor were not associated with WRS during NR. | 26278709 |
| Diabetes Mellitus, Periodontitis | Stem Cell Exhaustion | DKK1 rescues osteogenic differentiation of mesenchymal stem cells isolated from periodontal ligaments of patients with diabetes mellitus induced periodontitis. | 26278788 |
| Inflammation | Stem Cell Exhaustion | Recently mesenchymal stem cells derived from periodontal ligament (PDLSCs) have been utilized to reconstruct tissues destroyed by chronic inflammation. | 26278788 |
| Mycoses | Stem Cell Exhaustion | Incidence and risk factors of post-engraftment invasive fungal disease in adult allogeneic hematopoietic stem cell transplant recipients receiving oral azoles prophylaxis. | 26281032 |
| B-Cell Lymphomas | Stem Cell Exhaustion | High Doses of Antimetabolites Followed by High-Dose Sequential Chemoimmunotherapy and Autologous Stem-Cell Transplantation in Patients With Systemic B-Cell Lymphoma and Secondary CNS Involvement: Final Results of a Multicenter Phase II Trial. | 26282634 |
| Aggressive Non-Hodgkin Lymphoma | Stem Cell Exhaustion | HIV-negative patients with aggressive B-cell lymphoma and secondary CNS involvement at diagnosis or relapse, age 18 to 70 years, and Eastern Cooperative Oncology Group performance status <= 3 were enrolled and treated with high-doses of methotrexate and cytarabine, followed by R-HDS (cyclophosphamide, cytarabine, and etoposide) supported by autologous stem-cell transplantation (ASCT). | 26282634 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Clofarabine salvage therapy before allogeneic hematopoietic stem cell transplantation in patients with relapsed or refractory AML: results of the BRIDGE trial. | 26283567 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | In patients with relapsed or refractory (r/r) acute myeloid leukemia (AML), long-term disease control can only be achieved by allogeneic hematopoietic stem cell transplantation (HSCT). | 26283567 |
| leukemia, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | HLA haploidentical peripheral blood stem cell transplantation using reduced dose of posttransplantation cyclophosphamide for poor-prognosis or refractory leukemia and myelodysplastic syndrome. | 26284307 |
| Colorectal Carcinoma, Neoplasms | Stem Cell Exhaustion | We enriched CD133+ colorectal cancer cells which manifested the CSCs-like properties such as higher levels of other stem cell markers Oct-4 and Sox-2, tumor sphere forming ability and more tumorigenic in NOD/SCID mice. | 26284927 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells (CSCs) can invade and metastasize by epithelial-to-mesenchymal transition (EMT). | 26284927 |
| Neoplasms | Stem Cell Exhaustion | Prognostic genes were expressed in distinct tumor cell subpopulations, and genes implicated in proliferation and stem cells portended poor outcomes, while genes involved in normal lung differentiation and immune infiltration were associated with superior survival. | 26286589 |
| melanoma, Specialty Type - cancer | Stem Cell Exhaustion | Expression and prognostic value of putative cancer stem cell markers CD117 and CD15 in choroidal and ciliary body melanoma. | 26290260 |
| Specialty Type - cancer, Stage I Choroidal and Ciliary Body Melanoma AJCC v8 | Stem Cell Exhaustion | The aim of the present study was to immunohistochemically investigate the expression and prognostic significance of putative cancer stem cell markers CD117 (c-kit), CD34, CD20 and CD15 in a cohort of patients with primary choroidal and ciliary body melanoma. | 26290260 |
| Proximity | Stem Cell Exhaustion | BM resident mesenchymal stem cells (BM-MSCs) are altered in MM and in vitro studies indicate their transformation by MM proximity is within hours. | 26293751 |
| Multiple Myeloma | Stem Cell Exhaustion | Stem cell mobilization chemotherapy with gemcitabine is effective and safe in myeloma patients with bortezomib-induced neurotoxicity. | 26294015 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Plasma-Derived Fibronectin Stimulates Chondrogenic Differentiation of Human Subchondral Cortico-Spongious Progenitor Cells in Late-Stage Osteoarthritis. | 26295224 |
| Structure of articular cartilage | Stem Cell Exhaustion | Migration and chondrogenesis of human subchondral cortico-spongious progenitor cells (SPCs) are the key steps in the repair of microfracture-induced articular cartilage defects. | 26295224 |
| Fibrosis Assessment, Reperfusion Injury, Ischemia of kidney | Stem Cell Exhaustion | Amniotic Fluid Derived Stem Cells with a Renal Progenitor Phenotype Inhibit Interstitial Fibrosis in Renal Ischemia and Reperfusion Injury in Rats. | 26295710 |
| Kidney Diseases | Stem Cell Exhaustion | Mesenchymal stem cells derived from human amniotic fluid (hAFSCs) are a promising source for cellular therapy, especially for renal disorders, as a subpopulation is derived from the fetal urinary tract. | 26295710 |
| Interstitial Fibrosis Assessment | Stem Cell Exhaustion | hAFSCs contain a renal progenitor cell subpopulation that has a nephroprotective effect when delivered intra-arterially in rats with renal I/R injury, and reduces interstitial fibrosis on long term follow-up. | 26295710 |
| Brain Injuries | Stem Cell Exhaustion | The transcription factor Pax6 is a well-accepted neurogenic determinant during development, in adult neural progenitor cells and in acute brain injury models. | 26295830 |
| Breast Carcinoma, Childhood Breast Carcinoma | Stem Cell Exhaustion | Our purpose was to analyze the expression of FOXA2 in breast cancer cells, to explore its role in breast cancer stem cells, and to correlate its mRNA expression with clinicopathological features and outcome in a series of patients diagnosed with breast carcinoma. | 26298189 |
| Specialty Type - cancer | Stem Cell Exhaustion | We also knocked down FOXA2 mRNA expression by siRNA to determine the impact on cell proliferation and mammospheres formation using a cancer stem cells culture assay. | 26298189 |
| Specialty Type - cancer | Stem Cell Exhaustion | Our results suggest that FOXA2 promotes cell proliferation, maintains cancer stem cells, favors the development of Triple-Negative/Basal-like tumors, and is associated with increase relapses. | 26298189 |
| Specialty Type - cancer, Aggressive behavior, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Recently, there are several studies about cancer stem cells (CSC), indicating that they are the cells that initiate the tumor, provide progression, metastasis and responsible for the aggressive tumor behavior. | 26298632 |
| Kidney Failure, Acute, Injury of kidney | Stem Cell Exhaustion | Acute kidney injury (AKI) following stem-cell transplantation (SCT) contributes to a poor prognosis, yet its impact may vary depending on the timing of AKI onset. | 26301965 |
| Kidney Failure, Acute | Stem Cell Exhaustion | AKI prior to stem-cell engraftment was defined as early AKI and subsequently occurring AKI as late AKI. | 26301965 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Numerical impairment of nestin(+) bone marrow niches in acute GvHD after allogeneic hematopoietic stem cell transplantation for AML. | 26301968 |
| Graft-vs-Host Disease, Acute GVH disease, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | To investigate whether acute GvHD (aGvHD) reduces the number of N(+)SCN, we examined patients with AML who had undergone allogeneic hematopoietic stem cell transplantation. | 26301968 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | In patients with multiple myeloma (MM) undergoing autologous hematopoietic cell transplantation (auto-HCT), peripheral blood progenitor cells may be collected following mobilization with growth factor alone (GF) or cytotoxic chemotherapy plus GF (CC+GF). | 26301967 |
| Prostate carcinoma, Secondary Neoplasm | Stem Cell Exhaustion | Pristimerin Inhibits Prostate Cancer Bone Metastasis by Targeting PC-3 Stem Cell Characteristics and VEGF-Induced Vasculogenesis of BM-EPCs. | 26302893 |
| Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | The effect of Pristimerin on PC-3 stem cell characteristics and metastasis were detected by spheroid formation, CD133 and CD44 protein expression, matrix-gel invasive assay and colony-formation assay in vitro, VEGF and pro-inflammatory cytokines expression by ELISA assay, and tumor tumorigenicity by X-ray and MR in NOD-SCID mice model in vivo. | 26302893 |
| Secondary malignant neoplasm of prostate | Stem Cell Exhaustion | These data provide evidence that Pristimerin has strong potential for development as a novel agent against prostate bone metastasis by suppressing PC-3 stem cell characteristics and VEGF-induced vasculogenesis of BM-EPCs. | 26302893 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem-like cells are shown to be highly tumorigenic, pro-angiogenic and can significantly contribute to tumor new vessel formation and bone marrow derived-EPCs (BM-EPCs) are shown to recruit to the angiogenic switch in tumor growth and metastatic progression, suggesting the importance of targeting cancer stem cells (CSCs) and EPCs for novel tumor therapies. | 26302893 |
| Graft-vs-Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | We investigated the tear cytokine profiles in patients who underwent stem cell transplantation (SCT) and attempted to evaluate whether tear cytokines are associated with the presence of systemic chronic graft-versus-host disease (GVHD), regardless of ocular GVHD status. | 26303101 |
| Lymphoma | Stem Cell Exhaustion | Plerixafor (Mozobil): A Stem Cell-Mobilizing Agent for Transplantation in Lymphoma Patients Predicted to Be Poor Mobilizers - A Pilot Study. | 26303343 |
| Aggressive Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplantation is the standard therapy for refractory/relapsed aggressive lymphoma. | 26303343 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | We initiated a study to assess the use of plerixafor as a first-line stem cell mobilizer in 20 elderly or heavily pretreated patients with non-Hodgkin or Hodgkin lymphoma. | 26303343 |
| Atrial Fibrillation by ECG Finding | Stem Cell Exhaustion | Electromechanical mapping of the left ventricle for stem cell injection in a patient with permanent atrial fibrillation. | 26304029 |
| Usual Severity Pain, Ulcer | Stem Cell Exhaustion | This study was conducted to determine if intramuscular and intra-arterial stem cell injections delay or prevent major limb amputations, improve ankle-brachial index measurements, relieve rest pain, and improve ulcer healing. | 26304481 |
| Specialty Type - cancer | Stem Cell Exhaustion | Aldehyde dehydrogenase 1 (ALDH1) is a recognized cancer stem cell marker but little is known about its role in intratumoral stroma. | 26305673 |
| Liver carcinoma, Hollings Cancer Center, Hepatitis, Chronic | Stem Cell Exhaustion | Successful Interferon Therapy Reverses Enhanced Hepatic Progenitor Cell Activation in Patients with Chronic Hepatitis C. The enhanced accumulation of hepatic progenitor cells (HPCs) is related to the risk of progression to hepatocellular carcinoma (HCC). | 26308703 |
| Huntington disease-like syndrome due to C9ORF72 expansions | Stem Cell Exhaustion | Moreover, we identified a substantial defect in RNA export resulting in retention of RNA in the nuclei of Drosophila cells expressing expanded G4C2 repeats and also in mammalian cells, including aged induced pluripotent stem-cell-derived neurons from patients with C9orf72-related disease. | 26308899 |
| Diabetes | Stem Cell Exhaustion | To evaluate the acute effect of aerobic exercise (AE) and resistance exercise (RE) on the release of endothelial progenitor cell (EPCs, CD34+/KDR+/CD45 dim) and vascular function in type 1 diabetes (T1DM). | 26312614 |
| Diabetes Mellitus, Insulin-Dependent | Stem Cell Exhaustion | Exercise on Progenitor Cells in Healthy Subjects and Patients with Type 1 Diabetes. | 26312614 |
| X-linked inheritance, Immunologic Deficiency Syndromes | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (HSCT) outcomes in X-linked severe combined immune deficiency are most effective when performed with patients <3 months of age and without coexisting morbidity, and with donor cells from a matched sibling. | 26314823 |
| Specialty Type - cancer | Stem Cell Exhaustion | The purpose of this study was to evaluate the effect of ABCG2 monoclonal antibody (McAb) combined with paclitaxel (PTX) conjugated with Fe3O4 nanoparticles (NPs) on MM progressed from cancer stem cells (CSCs) in non-obese-diabetic/severe-combined-immunodeficiency (NOD/SCID) mouse model. | 26314844 |
| Alzheimers Disease | Stem Cell Exhaustion | Therapeutic Effects of Transplantation of As-MiR-937-Expressing Mesenchymal Stem Cells in Murine Model of Alzheimer's Disease. | 26316079 |
| Up | Stem Cell Exhaustion | A therapeutic effect of transplantation of mesenchymal stem cells (MSCs) into murine model of AD has been reported, but remains to be further improved. | 26316079 |
| Liver carcinoma, Hollings Cancer Center | Stem Cell Exhaustion | Sal-like protein 4 (SALL4), a stem cell marker, has been identified as a potential target for aggressive hepatocellular carcinoma (HCC). | 26317546 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | It has been considered that the detection methods for circulating tumor cells (CTCs) based on epithelial cell adhesion molecule (EpCAM) underestimate the number of CTCs and may miss a metastatic subpopulation with cancer stem cell (CSC) properties. | 26317979 |
| Osteoarthritis, Knee | Stem Cell Exhaustion | Assessment of clinical and MRI outcomes after mesenchymal stem cell implantation in patients with knee osteoarthritis: a prospective study. | 26318655 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Cartilage regenerative procedures using the cell-based tissue engineering approach involving mesenchymal stem cells (MSCs) have been receiving increased interest because of their potential for altering the progression of osteoarthritis (OA) by repairing cartilage lesions. | 26318655 |
| BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 20 | Stem Cell Exhaustion | This study aimed to investigate the relationship between circulating endothelial progenitor cell count and endothelial activation in a pediatric population with obesity. | 26321689 |
| Nausea, Blurred vision, Acute lymphocytic leukemia | Stem Cell Exhaustion | A 27-year-old woman with acute lymphocytic leukemia, who underwent allogeneic hematopoietic stem cell transplantation, complained of nausea and blurred vision 288 days after the transplantation. | 26321719 |
| Ischemia, Peripheral Arterial Diseases | Stem Cell Exhaustion | The extent and clinical significance of stem and progenitor cell (SPC) increases in response to lower-extremity ischemia in people with peripheral artery disease (PAD) are unclear. | 26324152 |
| Peripheral Arterial Diseases | Stem Cell Exhaustion | Ischemia-related changes in circulating stem and progenitor cells and associated clinical characteristics in peripheral artery disease. | 26324152 |
| B-Cell Lymphomas | Stem Cell Exhaustion | Induction chemotherapy followed by up-front autologous stem cell transplantation may have a survival benefit in high-risk diffuse large B-cell lymphoma patients. | 26325332 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | We compared the outcomes of patients with higher-risk diffuse large B-cell lymphoma (DLBCL) who were treated with either up-front autologous stem cell transplantation (ASCT) or salvage chemotherapy followed by delayed ASCT after relapse. | 26325332 |
| Relapsing course | Stem Cell Exhaustion | CD34-Selected Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Relapsed, High-Risk Multiple Myeloma. | 26325439 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | We report results of a retrospective analysis of 44 patients with relapsed and high-risk multiple myeloma (MM) undergoing allogeneic CD34-selected hematopoietic stem cell transplantation (HSCT) from HLA-compatible donors. | 26325439 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Autologous stem cell transplantation (ASCT) after high-dose melphalan conditioning is considered a standard of care procedure for patients with multiple myeloma (MM). | 26327631 |
| Irritable Bowel Syndrome, Abnormality of red blood cells | Stem Cell Exhaustion | Reduction in duodenal endocrine cells in irritable bowel syndrome is associated with stem cell abnormalities. | 26327765 |
| Irritable Bowel Syndrome | Stem Cell Exhaustion | To determine whether the decreased density of duodenal endocrine cells in irritable bowel syndrome (IBS) is associated with abnormalities in stem cell differentiation. | 26327765 |
| Adenoma, Acidophil Stem Cell Pituitary Gland Adenoma, Neoplasms | Stem Cell Exhaustion | Pathological examinations revealed an atypical, monomorphous plurihormonal Pit-1 lineage tumor with mixed features of silent subtype 3 adenoma and acidophil stem cell adenoma. | 26330191 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Autologous stem cell transplant-anticipated multiple myeloma or lymphoma patients were eligible. | 26331348 |
| Peripheral Stem Cell Transplantation | Stem Cell Exhaustion | The median age was 62.3 years; patients had a median of three prior lines of therapy (range 1-4), with over 70% of the patients having received prior lenalidomide, bortezomib, and/or peripheral blood stem cell transplant. | 26331432 |
| Acute myocardial infarction, Venous Stroke | Stem Cell Exhaustion | Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. | 26332322 |
| Pancreatic carcinoma, Secondary Neoplasm | Stem Cell Exhaustion | Nestin, a progenitor/stem cell marker, is expressed in human pancreatic cancer, where its expression correlates positively with invasiveness and metastasis. | 26335012 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Overall, the T-cell receptor b chain repertoire in chronic lymphocytic leukemia is likely shaped by antigen selection and the implicated antigenic elements may concern epitopes that also select the malignant B-cell progenitors or, more intriguingly, chronic lymphocytic leukemia-derived epitopes. | 26338994 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Expression of SOX-2 and Oct4 as markers for the identification of cancer stem cells (CSCs) has been revealed in several malignancies. | 26339387 |
| Thrombotic Microangiopathies, Unknown (origin) (qualifier value), Infection, Malignant Hypertension, Pathology, Autoimmune Diseases, Purpura, Thrombotic Thrombocytopenic, Hemorrhagic diarrhea | Stem Cell Exhaustion | Thrombocytopenic thrombotic purpura (TTP) is a thrombotic microangiopathy associated with hematopoietic stem cells transplantation, pregnancy, puerperium, drugs, bloody diarrhea, a heterogeneous group of illnesses, such as malignant hypertension, autoimmune and neoplastic diseases, infections, and an idiopathic group that includes the pathologies that don't apply for the preceding clinical categories. | 26339877 |
| Hematologic Neoplasms | Stem Cell Exhaustion | It has recently been shown that a T cell-replete allogeneic (allo) hematopoietic stem cell transplantation (HSCT) from a haploidentical donor (haplo-ID) could be a valid treatment for hematological malignancies. | 26341397 |
| Inflammation | Stem Cell Exhaustion | Adipose-derived stem cell (ADSC) transplantation is expected to be a minimally invasive, but effective, treatment for postoperative enterocutaneous fistulas associated with poor blood flow and chronic inflammation. | 26342817 |
| Communicable Diseases | Stem Cell Exhaustion | Bacterial infection remains a frequent complication in patients receiving a hematopoietic stem cell transplantation (HSCT). | 26343154 |
| leukemia | Stem Cell Exhaustion | We assessed functional consequences of modest reductions in PU.1 expression on leukemia development in mice harboring DNA lesions resembling those acquired during human stem cell aging. | 26343801 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Heterozygous deletion of an enhancer of PU.1, which resulted in a 35% reduction of PU.1 expression, was sufficient to induce myeloid-biased preleukemic stem cells and their subsequent transformation to AML in a DNA mismatch repair-deficient background. | 26343801 |
| Disease, Specialty Type - cancer, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | This study demonstrates that minimal reduction of a key lineage-specific transcription factor, which commonly occurs in human disease, is sufficient to initiate cancer development, and it provides mechanistic insight into the formation and progression of preleukemic stem cells in AML. | 26343801 |
| Leukemia, Myelomonocytic, Chronic | Stem Cell Exhaustion | Treatment with Hypomethylating Agents before Allogeneic Stem Cell Transplant Improves Progression-Free Survival for Patients with Chronic Myelomonocytic Leukemia. | 26343946 |
| Leukemia, Myelomonocytic, Chronic, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We retrospectively reviewed the data for 83 consecutive patients with CMML (47 with CMML-1/2 and 36 with CMML progressed to acute myeloid leukemia) who received an allogeneic stem cell transplant (allo-SCT) at our institution between April 1991 and December 2013 to identify factors associated with improved survival and determine whether treatment with hypomethylating agents before transplant improves progression-free survival (PFS). | 26343946 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Results were compared to a historical control group of sibling donors who received filgrastim for stem cell mobilization for allogeneic stem cell transplantations in patients with AML and MDS. | 26343949 |
| Fatigue, Graft-vs-Host Disease, Infection | Stem Cell Exhaustion | Allogeneic stem cell transplantation (allo-HCT) is associated with high treatment-related mortality and innumerable physical and psychosocial complications and side-effects, such as high fatigue levels, loss of physical performance, infections, graft-versus-host disease (GvHD) and distress. | 26345187 |
| Viremia | Stem Cell Exhaustion | Risk factors and outcomes of cytomegalovirus viremia in pediatric hematopoietic stem cell transplantation patients. | 26346369 |
| Cytomegalovirus Infections, Persistent CMV viremia | Stem Cell Exhaustion | We investigated the incidence, time of onset, risk factors for CMV viremia, and characteristics of CMV diseases in 57 pediatric patients receiving hematopoietic stem cell transplantation (HSCT). | 26346369 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Maintenance rituximab after autologous stem cell transplantation in patients with mantle cell lymphoma. | 26347113 |
| Medial collateral ligament, Mantle cell lymphoma | Stem Cell Exhaustion | High-dose therapy and autologous stem cell transplantation (ASCT) improves outcomes for patients with mantle cell lymphoma (MCL), but relapse ultimately occurs in most patients. | 26347113 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Pretransplantation Minimal Residual Disease Predicts Survival in Patients with Mantle Cell Lymphoma Undergoing Autologous Stem Cell Transplantation in Complete Remission. | 26348890 |
| Medial collateral ligament, Mantle cell lymphoma | Stem Cell Exhaustion | Autologous stem cell transplantation (ASCT) is standard therapy for mantle cell lymphoma (MCL) in remission after induction chemotherapy, with the best results for patients in complete remission (CR). | 26348890 |
| Abdominal Pain, Multiple Myeloma, Hemorrhagic diarrhea | Stem Cell Exhaustion | We describe the case of a 54-year-old woman with relapse of multiple myeloma 3 years after myeloablative allogeneic stem cell transplant who developed abdominal pain and bloody diarrhea following 7 months of lenalidomide therapy. | 26350196 |
| Neoplasms, Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | CD90(+) cells in and around blood vessels in cancers including brain tumors have been identified as endothelial cells, cancer stem cells, fibroblasts or pericytes. | 26350700 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | Philadelphia chromosome positive acute lymphoblastic leukemia is classified as a very high-risk group and it requires an intensive chemotherapy regimen associated with tyrosine-kinase inhibitors and allogeneic hematopoietic stem cell transplant from related or unrelated HLA matched donor. | 26351543 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Altered Expression of Wnt Signaling Pathway Components in Osteogenesis of Mesenchymal Stem Cells in Osteoarthritis Patients. | 26352263 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Osteoarthritis (OA) is characterized by altered homeostasis of joint cartilage and bone, whose functional properties rely on chondrocytes and osteoblasts, belonging to mesenchymal stem cells (MSCs). | 26352263 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | The purpose of this study was to determine the correlations between inflammatory factors-including absolute lymphocyte count, lactate dehydrogenase, b2-microglobulin, albumin, C-reactive protein, and ferritin-and the prognosis for survival in patients with multiple myeloma (MM) treated with induction chemotherapy containing thalidomide and who underwent autologous stem cell transplantation (ASCT). | 26354062 |
| CLTC gene, Hemorrhagic cystitis, Communicable Diseases | Stem Cell Exhaustion | Hemorrhagic cystitis (HC) is a common complication after hematopoietic allogeneic stem cell transplantation (HSCT) associated with intensity of the conditioning regimen, cyclophosphamide (Cy) therapy, and BK polyomavirus (BKPyV) infection. | 26354178 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Efficacy of stem cell in improvement of left ventricular function in acute myocardial infarction--MI3 Trial. | 26354213 |
| Specialty Type - cancer | Stem Cell Exhaustion | The sphere-forming hepatocytes expressed a number of cancer stem-like cell (CSC) markers, including high levels of the stem cell factor receptor c-Kit. | 26355082 |
| Alveolar rhabdomyosarcoma | Stem Cell Exhaustion | The presence of PAX3-FOXO1 in SNS and alveolar rhabdomyosarcoma suggests that these two entities are genetically similar lesions arising from distinct progenitor cell pools. | 26355893 |
| Pulmonary Complication | Stem Cell Exhaustion | A retrospective analysis of computed tomography findings in patients with pulmonary complications after allogeneic hematopoietic stem cell transplantation. | 26358372 |
| Pulmonary Complication | Stem Cell Exhaustion | The purpose of this study was to review the high-resolution computed tomography (CT) findings in patients with pulmonary complications after allogeneic hematopoietic stem cell transplantation (HSCT), and to evaluate the relationship between CT findings and clinical outcomes. | 26358372 |
| Arterial Stiffness, Lupus Erythematosus, Metabolic Syndrome X | Stem Cell Exhaustion | Metabolic syndrome is associated with decreased circulating endothelial progenitor cells and increased arterial stiffness in systemic lupus erythematosus. | 26359174 |
| Arterial Stiffness, Atherosclerosis, ETV3 gene | Stem Cell Exhaustion | We examined the contribution of MetS to inflammatory markers, arterial stiffness and circulating endothelial progenitor cells (EPCs) as surrogates of subclinical atherosclerosis. | 26359174 |
| Sample Size Calculation | Stem Cell Exhaustion | NRP1 expression was assessed in SSc and healthy dermal microvascular endothelial cells (SSc-MVECs and H-MVECs), and in SSc and control endothelial progenitor cell (EPC)-derived endothelial cells (ECs). | 26359450 |
| Weight decreased, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Pre-transplant weight loss predicts inferior outcome after allogeneic stem cell transplantation in patients with myelodysplastic syndrome. | 26360778 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Allogeneic stem cell transplantation (alloSCT) represents a curative therapeutic option for patients with myelodysplastic syndrome (MDS), but relapse and non-relapse mortality (NRM) limit treatment efficacy. | 26360778 |
| Multiple Myeloma | Stem Cell Exhaustion | We compared outcomes between high-risk and standard-risk myeloma patients who underwent autologous hematopoietic stem-cell transplantation (auto-HCT) at our institution between January 2005 and December 2009. | 26361647 |
| Fanconi Anemia | Stem Cell Exhaustion | A Successful Second Stem Cell Transplantation in Fanconi Anemia: A Case Report. | 26361704 |
| Fanconi Anemia | Stem Cell Exhaustion | The aim was to describe a case of successful second stem cell transplantation in Fanconi anemia (FA). | 26361704 |
| Disturbance | Stem Cell Exhaustion | Since endothelial progenitor cells (CD34-positive cells) have been reported to contribute to vascular repair, our results indicate that in non-hypertensive subjects, triglycerides may stimulate an increase in circulating CD34-positive cells (vascular repair) by inducing vascular disturbance. | 26363435 |
| Failure, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Disease relapse is the major causes of treatment failure after allogeneic stem cell transplantation (SCT) in patients with acute myeloid leukemia (AML). | 26363443 |
| Superficial abrasion, Hydrarthrosis | Stem Cell Exhaustion | Abrasion arthroplasty increases mesenchymal stem cell content of postoperative joint effusions. | 26364138 |
| Specialty Type - cancer | Stem Cell Exhaustion | CD44, SOX2 and SHH have been implicated in resistance to CRT, possibly through an association with a cancer stem cell phenotype. | 26364884 |
| Neoplasms | Stem Cell Exhaustion | Survival of patients who develop solid tumors following hematopoietic stem cell transplantation. | 26367222 |
| Respiratory Tract Infections | Stem Cell Exhaustion | Mortality in hematopoietic stem cell transplant recipients with lower respiratory tract RSV infection can exceed 80%. | 26367224 |
| Histocompatibility | Stem Cell Exhaustion | UGT2B17 minor histocompatibility mismatch and clinical outcome after HLA-identical sibling donor stem cell transplantation. | 26367234 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Minor histocompatibility Ags (mHags) have been implicated in the pathogenesis of GVHD after allogeneic hematopoietic stem cell transplantation (HSCT). | 26367234 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | Salvage chemotherapy followed by autologous stem cell transplantation (ASCT) is the standard second-line treatment for relapsed and refractory diffuse large B-cell lymphoma (DLBCL). | 26367239 |
| Asthma, Fibrosis Assessment | Stem Cell Exhaustion | Fibrocytes are bone marrow-derived circulating progenitor cells that have been implicated in tissue fibrosis and T(H)2 responses in asthmatic patients. | 26371837 |
| Leukemia, Myelomonocytic, Chronic, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Azacitidine is a demethylating and cytotoxic drug for the treatment of adult patients with (1) myelodysplastic syndromes, (2) chronic myelomonocytic leukemia, and (3) acute myeloid leukemia who are not eligible for induction treatment or hematopoietic stem cell transplantation. | 26371947 |
| Nystagmus, Farber Lipogranulomatosis | Stem Cell Exhaustion | A 30 months-old boy with Farber disease developed nystagmus 12 months after hematopoietic stem cell transplantation (HSCT). | 26373951 |
| Burn injury | Stem Cell Exhaustion | Chemical burns remain the main cause of limbal stem cell deficiency. | 26375332 |
| Hematologic Neoplasms | Stem Cell Exhaustion | However, there is no standard protocol indicating the use of HEPA filters for patients with hematological malignancies, except for those who have undergone allogeneic hematopoietic stem cell transplantation. | 26376622 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disease. | 26376664 |
| Autoimmune hemolytic anemia | Stem Cell Exhaustion | Eligible patients had a WHO performance status of 0-2, had a response assessment within the previous 3 months, did not have refractory disease, autoimmune haemolytic anaemia requiring treatment, chronic or active infection requiring treatment, and had not previously received maintenance treatment or autologous or allogeneic stem-cell transplant. | 26377300 |
| Lymphoma, Non-Hodgkin, Familial, Hodgkin Disease, Lymphoma, Non-Hodgkin, LIPC gene | Stem Cell Exhaustion | High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (AHCT) is a well-defined treatment modality for relapsed/refractory non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL). | 26377357 |
| Autoimmune Diseases | Stem Cell Exhaustion | Allogeneic and xenogeneic transplantation are suitable alternatives for treating patients with stem cell defects and autoimmune diseases. | 26377835 |
| Lupus Erythematosus | Stem Cell Exhaustion | Comparative Efficacies of Long-Term Serial Transplantation of Syngeneic, Allogeneic, Xenogeneic, or CTLA4Ig-Overproducing Xenogeneic Adipose Tissue-Derived Mesenchymal Stem Cells on Murine Systemic Lupus Erythematosus. | 26377835 |
| Lupus Erythematosus, Encephalitis, St. Louis | Stem Cell Exhaustion | The purpose of this study was to compare the effects of long-term serial transplantation of adipose tissue-derived mesenchymal stem cells (ASCs) from (NZB x NZW) F1 mice (syngeneic), BALB/c mice (allogeneic), or humans (xenogeneic) on systemic lupus erythematosus (SLE). | 26377835 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | This case illustrates an association between atypical chronic myeloid leukemia and steroid-responsive paraneoplastic vasculitis and highlights the single-agent disease activity of decitabine in atypical chronic myeloid leukemia, which may be utilized as a bridging therapy to allogeneic stem cell transplantation. | 26378157 |
| Autoimmune Diseases | Stem Cell Exhaustion | For patients with severe and refractory autoimmune diseases, high-dose chemotherapy and autologous hematopoietic stem cell transplantation has been established as a considerable therapeutic option in recent years. | 26381040 |
| Autoimmune Diseases | Stem Cell Exhaustion | Low-dose cyclophosphamide effectively mobilizes peripheral blood stem cells in patients with autoimmune disease. | 26381040 |
| Autoimmune Diseases | Stem Cell Exhaustion | In this retrospective single-center analysis, we assessed the feasibility and efficacy of peripheral blood stem cells (PBSC) mobilization and collection in 35 patients with refractory autoimmune disease (AID). | 26381040 |
| Doxorubicin/Methotrexate/Vinblastine, Arteriovenous Malformations, Cerebral | Stem Cell Exhaustion | Our report illustrates a unique case of de novo development of a cerebral arteriovenous malformation (AVM) after implantation of genetically modified allogeneic mesenchymal stem cells in the brain. | 26382859 |
| Doxorubicin/Methotrexate/Vinblastine | Stem Cell Exhaustion | The development of an AVM within a period of 3 years after implantation of the glucagon-like peptide-1-secreting mesenchymal stem cells suggests a possible relationship. | 26382859 |
| Keratoconjunctivitis | Stem Cell Exhaustion | Stem Cell Factor and Thymic Stromal Lymphopoietin Overexpression With Correlation to Mast Cells in Superior Limbic Keratoconjunctivitis. | 26382891 |
| Keratoconjunctivitis, Stem Cell Factor | Stem Cell Exhaustion | To investigate the differential expression of stem cell factor (SCF) and thymic stromal lymphopoietin (TSLP) and their correlation to mast cells, between patients diagnosed with superior limbic keratoconjunctivitis (SLK) and normal subjects. | 26382891 |
| Bronchiolitis Obliterans, Allogeneic Hematopoietic Stem Cell Transplantation | Stem Cell Exhaustion | Prognostic role of FEV1 for survival in bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation. | 26383085 |
| Bronchiolitis Obliterans, Bosnian language | Stem Cell Exhaustion | Bronchiolitis obliterans syndrome (BOS) can occur after hematopoietic stem cell transplantation (HSCT) and is associated with significant mortality. | 26383085 |
| Colorectal Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | A new insight into cancer stem cell markers: Could local and circulating cancer stem cell markers correlate in colorectal cancer? | 26383518 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cell (CSC) markers could serve as potential prognostic procedure. | 26383518 |
| Malignant Peripheral Nerve Sheath Tumor | Stem Cell Exhaustion | This association might be explained by the chronic inflammatory state and oxidative stress in response to smoking, eliciting genomic instability in the stem cell compartment and ultimately clonal evolution resulting in MPNs. | 26384085 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Steroid-refractory acute graft-versus-host disease (aGVHD) remains an important cause of morbidity and mortality after allogeneic stem cell transplantation (SCT). | 26386320 |
| Stomach Carcinoma | Stem Cell Exhaustion | Prognostic significance of leucine-rich-repeat-containing G-protein-coupled receptor 5, an intestinal stem cell marker, in gastric carcinomas. | 26386561 |
| Malignant tumor of colon, Specialty Type - cancer | Stem Cell Exhaustion | Cells expressing LGR5, an intestinal stem cell marker, have been suggested as cancer stem cells in human colon cancers. | 26386561 |
| Gastric Adenoma | Stem Cell Exhaustion | In addition, most gastric adenomas contain abundant LGR5-expressing cells coexpressing intestinal stem cell signatures. | 26386561 |
| Specialty Type - cancer, Malignant neoplasm of skin | Stem Cell Exhaustion | Comparative expression analysis of putative cancer stem cell markers CD44 and ALDH1A1 in various skin cancer subtypes. | 26391478 |
| Specialty Type - cancer, melanoma, Neoplasms, Malignant neoplasm of skin | Stem Cell Exhaustion | Skin cancers, particularly melanoma, are initiated and maintained by a subpopulation of tumor cells expressing stemness markers that are called cancer stem cells (CSCs). | 26391478 |
| Diabetes Mellitus | Stem Cell Exhaustion | For the patients who received rituximab-containing chemotherapy, the risk factors included female gender, diabetes mellitus, multiple courses of chemotherapy, autologous hematopoietic stem cell transplantation and higher accumulated rituximab dose. | 26391893 |
| Neutrophilic dermatosis, MYELODYSPLASTIC SYNDROME, Myeloproliferation, Leukemia, Myelomonocytic, Chronic, Polyarthritis, Vasculitis, CTCAE, Autoimmune Diseases | Stem Cell Exhaustion | Chronic myelomonocytic leukemia (CMML), a clonal hematopoietic stem cell disorder with myelodysplastic and myeloproliferative overlap feature, is frequently associated with autoimmune diseases, such as vasculitis, polyarthritis, and neutrophilic dermatosis. | 26392142 |
| Transplant-Related Malignant Neoplasm, Comorbidity | Stem Cell Exhaustion | Although the application of Hematopoietic Cell Transplantation-specific Comorbidity Index (HCT-CI) has enabled better prediction of transplant-related mortality (TRM) in allogeneic hematopoietic stem cell transplants (AHSCT), data from developing countries are scarce. | 26394228 |
| Amyotrophic Lateral Sclerosis | Stem Cell Exhaustion | We studied a new method of treatment of amyotrophic lateral sclerosis with autologous mesenchymal stem cells. | 26395626 |
| Acute leukemia | Stem Cell Exhaustion | Patients undergoing haematopoietic stem cell transplantation or chemotherapy for acute leukaemia were enrolled for biomarker screening. | 26400571 |
| Pancytopenia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | A 4-year-old girl with history of acute myeloid leukemia post chemotherapy and stem cell transplant presented with pancytopenia. | 26402136 |
| Bone necrosis | Stem Cell Exhaustion | Decreased Osteogenic Activity of Mesenchymal Stem Cells in Patients With Corticosteroid-Induced Osteonecrosis of the Femoral Head. | 26404846 |
| Stem cells | Stem Cell Exhaustion | Is the protein expression window during testicular development affected in patients at risk for stem cell loss? | 26405262 |
| Stem cells | Stem Cell Exhaustion | Is the protein expression window during testicular development affected in prepubertal patients at risk for stem cell loss? | 26405262 |
| Specialty Type - cancer | Stem Cell Exhaustion | A minority of cancer cells with characteristics of cancer stem cells (CSC) may be responsible for progression and development of chemotherapy resistance in this disease. | 26406410 |
| Immunocompromised Host | Stem Cell Exhaustion | Immunocompromised patients comprised 8 hematopoietic stem cell transplant recipients (group A) and 9 immunosuppressive therapy recipients (group B), and controls consisted of 14 children aged >1 year (group C) and 22 infants (group D). | 26410591 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Chronic myelogenous leukaemia (CML) is a hematopoietic stem cell disease with a relatively stable clinical course. | 26411119 |
| Cholangiolocellular Carcinoma, Malignant neoplasm of liver | Stem Cell Exhaustion | Cholangiolocellular carcinoma (CoCC) is a rare type of malignant liver tumor derived from hepatic stem cells, which exist in the canals of Hering. | 26414834 |
| Malignant neoplasm of pancreas, Malignant neoplasm of gastrointestinal tract | Stem Cell Exhaustion | They also drive intestinal stem cell proliferation and positioning, control intestinal tissue boundaries and are involved in liver, pancreatic and colorectal cancers, indicating involvement in additional digestive system malignancies. | 26414866 |
| Infection of bloodstream | Stem Cell Exhaustion | High Incidence of Afebrile Bloodstream Infection Detected by Surveillance Blood Culture in Patients on Corticosteroid Therapy after Allogeneic Hematopoietic Stem Cell Transplantation. | 26415560 |
| Behavioral Symptoms Index Composite Score (BASC-2), Infection of bloodstream | Stem Cell Exhaustion | Bloodstream infections (BSI) are still important complications after allogeneic hematopoietic stem cell transplantation (allo-SCT). | 26415560 |
| Primary cutaneous lymphoma | Stem Cell Exhaustion | Allogeneic stem-cell transplantation in patients with cutaneous lymphoma: updated results from a single institution. | 26416896 |
| TSPYL2 gene | Stem Cell Exhaustion | In this article, we report the largest single-center experience with allogeneic stem-cell transplantation (SCT) for advanced CTCL. | 26416896 |
| Pregnancy | Stem Cell Exhaustion | Our findings indicate that stem cell deficiency and accelerated stromal senescence limit the differentiation capacity of the endometrium and predispose for pregnancy failure. | 26418742 |
| Cytogenetic Complete Response | Stem Cell Exhaustion | Our investigation demonstrated that CRC cells with silenced NDRG1 showed more tumorigenic ability and stem cell-like properties, such as: colony and sphere formation, chemoresistance, cell invasion, high expression of CD44, and tumorigenicity in vivo. | 26418878 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Acute graft-versus-host disease (aGvHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. | 26418955 |
| Metabolic Bone Disorder, Osteoporosis | Stem Cell Exhaustion | Collectively, these results may point to the GCN5-NF-kB pathway as a novel potential molecular target for stem cell mediated regenerative medicine and the treatment of metabolic bone diseases such as osteoporosis. | 26420353 |
| Malignant Pleural Mesothelioma | Stem Cell Exhaustion | Expression of the Stem Cell Factor Nestin in Malignant Pleural Mesothelioma Is Associated with Poor Prognosis. | 26421614 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Reconstitution of lymphocyte subpopulations after hematopoietic stem cell transplantation: comparison of hematologic malignancies and donor types in event-free patients. | 26422556 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | CD25 expression on residual leukemic blasts at the time of allogeneic hematopoietic stem cell transplant predicts relapse in patients with acute myeloid leukemia without complete remission. | 26422713 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Risk factors for outcome in refractory acute myeloid leukemia patients treated with a combination of fludarabine, cytarabine, and amsacrine followed by a reduced-intensity conditioning and allogeneic stem cell transplantation. | 26424692 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (HCT) is considered a standard treatment for high-risk acute myeloid leukemia (AML) in first or second complete remission (CR). | 26424692 |
| Fibrosis Assessment, Malignant Neoplasms, Pneumonia, Interstitial | Stem Cell Exhaustion | Moreover, 4 patients who had chemotherapy and hematopoietic stem cell transplantation due to hematologic malignancy showed unclassifiable interstitial pneumonia with extensive fibrosis in the lungs. | 26425040 |
| End Stage Liver Disease | Stem Cell Exhaustion | Reinfusion of highly purified CD133+ bone marrow-derived stem/progenitor cells in patients with end-stage liver disease: A phase I clinical trial. | 26427587 |
| Tissue injury | Stem Cell Exhaustion | Bone marrow stem/progenitor cells seem to be effective in liver regeneration after tissue injury. | 26427587 |
| End Stage Liver Disease | Stem Cell Exhaustion | To evaluate the feasibility and safety of the mobilization and reinfusion of CD133+ stem/progenitor cells in patients with end-stage liver disease. | 26427587 |
| End Stage Liver Disease | Stem Cell Exhaustion | 16 subjects with Model for End-stage Liver Disease (MELD) score between 17 and 25 were enrolled, 14 mobilized an adequate number of CD133+ stem/progenitor cells and 12 were reinfused. | 26427587 |
| End Stage Liver Disease | Stem Cell Exhaustion | CD133+ stem/progenitor cells reinfusion in patients with end-stage liver disease is feasible and safe. | 26427587 |
| Multiple Myeloma | Stem Cell Exhaustion | To evaluate the feasibility of selecting a mobilization regimen based on the response to induction therapy, we retrospectively analyzed 179 multiple myeloma patients who underwent stem cell mobilization. | 26428939 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Busulfan plus cyclophosphamide versus busulfan plus fludarabine as a preparative regimen for allogeneic haemopoietic stem-cell transplantation in patients with acute myeloid leukaemia: an open-label, multicentre, randomised, phase 3 trial. | 26429297 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The standard busulfan-cyclophosphamide myeloablative conditioning regimen is associated with substantial non-relapse mortality in patients older than 40 years with acute myeloid leukaemia who are undergoing allogeneic stem-cell transplantation. | 26429297 |
| Mycoses | Stem Cell Exhaustion | Reduction in incidence of invasive fungal infection in patients receiving allogeneic stem cell transplantation using combined diagnostic-driven approach and itraconazole oral solution. | 26429354 |
| Mycoses | Stem Cell Exhaustion | Invasive fungal infections are an important cause of morbidity and mortality after allogeneic haematopoietic stem cell transplantation. | 26429354 |
| Neutropenia, Mycoses | Stem Cell Exhaustion | We evaluated, in our allogeneic stem cell transplant patients, the effect on the incidence of invasive fungal infection during neutropenia of a strategy combining a diagnostic-driven approach with chemoprophylaxis during higher risk periods of graft vs. host disease and prolonged neutropenia, using itraconazole oral solution with parenteral voriconazole bridging. | 26429354 |
| Breast Carcinoma, Specialty Type - cancer, Childhood Breast Carcinoma, Triple-Negative Breast Cancer Finding | Stem Cell Exhaustion | Here, we show that MCM2 is highly expressed in clinical samples of invasive carcinoma of the breast, especially triple-negative breast cancer (TNBC), and in cancer stem cell (CSC) marker-positive breast cancer cells. | 26430873 |
| Heterotopic Ossification, Hypoxia | Stem Cell Exhaustion | The impact of hypoxia on mesenchymal progenitor cells of human skeletal tissue in the pathogenesis of heterotopic ossification. | 26432574 |
| Healthcare Encounters Domain, Heterotopic Ossification | Stem Cell Exhaustion | Mesenchymal progenitor cells (MPCs) are capable of differentiating into osteo/chondrogenic cells to contribute substantially to heterotopic ossification (HO). | 26432574 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Genome-wide surveillance of mismatched alleles for graft-versus-host disease in stem cell transplantation. | 26432889 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Acute graft-versus-host disease (aGVHD) represents one of the major complications in allogeneic stem cell transplantation and is primarily caused by genetic disparity between the donor and recipient. | 26432889 |
| Malignant Neoplasms | Stem Cell Exhaustion | The characterisation of dividing brain cells is fundamental for studies ranging from developmental and stem cell biology, to brain cancers. | 26432933 |
| Polycythemia Vera, Erythrocytosis, Primary Myelofibrosis, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Polycythemia vera (PV) is a clonal stem cell disorder characterized by erythrocytosis and associated with burdensome symptoms, reduced quality of life, risk of thrombohemorrhagic complications, and risk of transformation to myelofibrosis and acute myeloid leukemia. | 26433906 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Subtle lesions of terminal hepatic venules (THVs) may be overlooked in liver biopsies from haematopoietic stem cell transplant (HSCT) receipients when graft-versus-host disease is the clinical concern. | 26434389 |
| Multiple Myeloma | Stem Cell Exhaustion | A randomized phase II study of stem cell mobilization with cyclophosphamide+G-CSF or G-CSF alone after lenalidomide-based induction in multiple myeloma. | 26437056 |
| Acute leukemia | Stem Cell Exhaustion | Limited therapeutic options are available after relapse of acute leukaemia following first reduced intensity conditioning haematopoietic stem cell transplantation (RIC1). | 26437057 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Long-term results of adjuvant donor lymphocyte transfusion in AML after allogeneic stem cell transplantation. | 26437060 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Adjuvant transfusion of donor lymphocytes (aDLT) may reduce the risk of relapse after allogeneic stem cell transplantation in high-risk AML. | 26437060 |
| Dysautonomia, Familial | Stem Cell Exhaustion | Familial Dysautonomia (FD) Human Embryonic Stem Cell Derived PNS Neurons Reveal that Synaptic Vesicular and Neuronal Transport Genes Are Directly or Indirectly Affected by IKBKAP Downregulation. | 26437462 |
| Dysautonomia, Familial | Stem Cell Exhaustion | Here we found new molecular insights for the IKAP role and the impact of the FD mutation in the human PNS lineage by using a novel and unique human embryonic stem cell (hESC) line homozygous to the FD mutation originated by pre implantation genetic diagnosis (PGD) analysis. | 26437462 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Twenty-one (55%) patients had newly diagnosed AML, 14 (37%) had relapsed AML, and 3 (8%) underwent bridging therapy before allogeneic stem-cell transplantation. | 26437871 |
| Myeloproliferative disease | Stem Cell Exhaustion | Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms. | 26438359 |
| Neoplasms, Communicable Diseases | Stem Cell Exhaustion | NK cells play a major role in protection against tumor recurrence and infection after allogeneic hematopoietic stem cell transplantation (HSCT). | 26438526 |
| Aplastic Anemia | Stem Cell Exhaustion | Impairment of hematopoietic stem cell niches in patients with aplastic anemia. | 26440975 |
| Hematopoietic stem cells | Stem Cell Exhaustion | These data indicate that AA is associated with impaired hematopoietic stem cell niches. | 26440975 |
| Colorectal Carcinoma | Stem Cell Exhaustion | Clinical significance of stem cell marker CD133 expression in colorectal cancer. | 26442717 |
| Neoplasms | Stem Cell Exhaustion | CD133, a glycoprotein, is expressed in different types of human stem cells and tumor cells. | 26442717 |
| Growth | Stem Cell Exhaustion | Down-regulation of DCLK1 results in loss of cancer-stem-cells (CSCs), and inhibits spheroidal/xenograft growths from hCRC-cells. | 26447334 |
| Double-Hit Lymphoma | Stem Cell Exhaustion | Patients with MYC/BCL2 double-hit lymphoma (DHL) are known to have an aggressive clinical course and to respond poorly to various therapies including intensive chemotherapy and stem cell transplant. | 26448193 |
| Mucoepidermoid Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Here, we investigated the expression of putative cancer stem cell markers (ALDH, CD10, CD24, CD44) in primary human mucoepidermoid carcinomas by immunofluorescence, in vitro salisphere assays, and in vivo tumorigenicity assays in immunodeficient mice. | 26449187 |
| Specialty Type - cancer | Stem Cell Exhaustion | ALDH/CD44 identifies uniquely tumorigenic cancer stem cells in salivary gland mucoepidermoid carcinomas. | 26449187 |
| Neoplasms | Stem Cell Exhaustion | These unique cells, namedcancer stem cells, are considered drivers of tumor progression in these tumors. | 26449187 |
| Specialty Type - cancer | Stem Cell Exhaustion | The purpose of this work is to understand if cancer stem cells play a functional role in the tumorigenesis of salivary gland mucoepidermoid carcinomas. | 26449187 |
| Specialty Type - cancer | Stem Cell Exhaustion | Collectively, these data demonstrate that salivary gland mucoepidermoid carcinomas contain a small population of cancer stem cells with enhanced tumorigenic potential and that are characterized by high ALDH activity and CD44 expression. | 26449187 |
| Acute leukemia | Stem Cell Exhaustion | In patients with acute leukaemia and recipients of haematopoietic stem cell and solid organ transplants the predicted incidence is more than 55 every year. | 26449504 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Chronic graft-vs.-host disease (GVHD) is a severe and potentially fatal complication in patients after undergoing allogeneic stem cell transplant. | 26449730 |
| Hematologic Neoplasms | Stem Cell Exhaustion | We report four cases of patients seen at Stanford Hospital between January 2013 to December 2014 with hematologic malignancy who developed hyperkeratotic papules and plaques on the palms and soles after allogeneic hematopoietic stem cell transplant. | 26449730 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Donor lymphocyte infusion (DLI) is used for treatment of hematologic malignancy relapse or mixed chimerism after allogeneic hematopoietic stem cell transplantation. | 26449992 |
| Communicable Diseases | Stem Cell Exhaustion | Allogeneic stem cell transplantation (allo-HSCT) provides a unique opportunity to track Epstein-Barr virus (EBV) infection in the context of the reconstituting B-cell system. | 26450987 |
| Best Case Imputation Technique, Bladder Carcinoma Infiltrating the Muscle of the Bladder Wall, Specialty Type - cancer | Stem Cell Exhaustion | Striking evidence associates cancer stem cells (CSCs) to the high recurrence rates and poor survival of patients with muscle-invasive bladder cancer (BC). | 26452033 |
| Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | We report a 35-year-old female patient with cerebral manifestations of chronic graft-versus-host disease (cGvHD) and putative retinal involvement after allogeneic peripheral blood stem cell transplantation (alloHSCT). | 26452109 |
| Inflammation, Specialty Type - cancer, Congenital contractural arachnodactyly | Stem Cell Exhaustion | Surprisingly, let-7c/miR-99a/miR-125b cluster also significantly decreased the ability of CCA cells for cancer stem cell-like mammosphere generation by downregulating CD133 and CD44, which suggests the pivotal roles of let-7c, miR-99a and miR-125b in CCA by regulating both inflammation and stem-like properties. | 26455324 |
| Fecal Incontinence, Colonization, Communicable Diseases | Stem Cell Exhaustion | Our multivariate analysis identified factors associated with a significant risk for CRKP colonization or infection: solid organ or stem cell transplantation (OR, 5.05; 95% CI, 1.23-20.8; P=.03), mechanical ventilation (OR, 2.56; 95% CI, 1.24-5.28; P=.01), fecal incontinence (OR, 5.78; 95% CI, 1.52-22.0; P=.01), and exposure in the prior 30 days to meropenem (OR, 3.55; 95% CI, 1.04-12.1; P=.04), vancomycin (OR, 2.94; 95% CI, 1.18-7.32; P=.02), and metronidazole (OR, 4.22; 95% CI, 1.28-14.0; P=.02). | 26455382 |
| Medial collateral ligament, Mantle cell lymphoma | Stem Cell Exhaustion | Autologous stem cell transplant (ASCT) can improve outcomes for mantle cell lymphoma (MCL) patients, yet relapses are frequent. | 26455717 |
| Pseudallescheria, Aspergillus fumigatus allergenic extract | Stem Cell Exhaustion | Pseudallescheria boydii with Aspergillus fumigatus and Aspergillus terreus in a Critically Ill Hematopoietic Stem Cell Recipient with ARDS. | 26455910 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease is a major complication of allogeneic hematopoietic stem cell transplantation. | 26456486 |
| Specialty Type - cancer | Stem Cell Exhaustion | Clinical influence of cancer stem cells on residual disease after preoperative chemoradiotherapy for rectal cancer. | 26456957 |
| Specialty Type - cancer, Rectal Carcinoma | Stem Cell Exhaustion | We evaluated the clinical influence of cancer stem cells (CSCs) on residual disease after preoperative chemoradiotherapy (CRT) in patients with rectal cancer. | 26456957 |
| Hodgkin Disease, LIPC gene | Stem Cell Exhaustion | High-dose chemotherapy (HDT) with autologous stem cell transplantation is the standard of care for relapsed/refractory (RR) Hodgkin lymphoma (HL). | 26458240 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | [The role of hematopoietic stem cell transplantation for acute myeloid leukemia]. | 26458433 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (HSCT) plays an important role in treating younger patients with acute myeloid leukemia (AML). | 26458433 |
| Bone Marrow Lymphoplasmacytic Infiltrate, Hyperviscosity, Waldenstrom Macroglobulinemia | Stem Cell Exhaustion | Waldenstrom macroglobulinemia (WM) is a rare and incurable B-cell neoplasm characterized by lymphoplasmacytic bone marrow infiltration and the production of serum monoclonal immunoglobulin M. Therapeutic strategies for WM should be based on individual patient and disease characteristics, including age, suitability as a candidate for autologous stem cell transplantation, hyperviscosity, and comorbidities. | 26458447 |
| Specialty Type - cancer | Stem Cell Exhaustion | ALDH1 is a crucial element in the retinoic acid signaling pathway regulating the self-renewal and differentiation of normal stem cells, and may play an important role in cancer progression. | 26462023 |
| Inflammation, Ischemia | Stem Cell Exhaustion | Inflammation is associated with a reduced number of pro-angiogenic Tie-2 monocytes and endothelial progenitor cells in patients with critical limb ischemia. | 26462497 |
| Specialty Type - cancer | Stem Cell Exhaustion | In vitro assay demonstrated that CXCL10 stimulus increased the rate of CD133(+) cancer stem cells (CSCs) in HepG2 cells by binding to CXCR3 and then inducing c-Myc expression. | 26462839 |
| Multiple Myeloma | Stem Cell Exhaustion | Multiple myeloma is the most common indication for high-dose chemotherapy and autologous stem cell transplantation (ASCT), and lenalidomide maintenance after transplant is now standard. | 26464015 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | A 59-year-old female received a matched related donor stem cell transplant for chronic myelogenous leukemia. | 26464160 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Long-term outcome of patients with newly diagnosed chronic myeloid leukemia: a randomized comparison of stem cell transplantation with drug treatment. | 26464170 |
| Adenocarcinoma of lung (disorder), Specialty Type - cancer | Stem Cell Exhaustion | Epithelial-mesenchymal transition in patients of pulmonary adenocarcinoma: correlation with cancer stem cell markers and prognosis. | 26464642 |
| Malignant neoplasm of lung | Stem Cell Exhaustion | The existence of lung cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT) in human tissue is controversy. | 26464642 |
| Histiocytosis, Histiocytic Disorders, Malignant, Histiocytosis, Langerhans-Cell | Stem Cell Exhaustion | The coexistence of LCH and ECD in the same biopsy and the BRAF (V600E) mutation status in both histologic types support the recent re-classification of the histiocytic disorder into LCH, ECD, and "mixed histiocytosis", which reflects tumorigenesis for all three from a common progenitor cell. | 26466952 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Differential expression of epithelial-mesenchymal transition and stem cell markers in intrinsic subtypes of breast cancer. | 26467042 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | This information is important in understanding the biology of triple negative breast cancer, also in terms of future studies dealing with targeted therapies based on the alterations of EMT and stem cell markers. | 26467042 |
| Cardiovascular Diseases | Stem Cell Exhaustion | It has been proposed that vascular progenitor cells play an important role in vascular repair, but their possible clinical importance in cardiovascular disease has not been fully characterized. | 26467529 |
| Stem Cell Factor | Stem Cell Exhaustion | To our knowledge, this is the first clinical study to provide evidence to support a key role for SCF and progenitor cells in vascular repair. | 26467529 |
| Myeloproliferative disease | Stem Cell Exhaustion | Myeloproliferative neoplasms (MPN) are chronic myeloid cancers thought to arise at the level of CD34+ hematopoietic stem/progenitor cells. | 26468945 |
| Secondary Graft Failure After Hematopoietic Cell Transplantation | Stem Cell Exhaustion | Secondary failure of platelet recovery (SFPR) is a serious complication observed in approximately 20% of allogeneic hematopoietic stem cell transplant (HSCT) recipients. | 26471738 |
| Chronic heart failure | Stem Cell Exhaustion | Increased red cell distribution width is associated with poor stem cell mobilization in patients with advanced chronic heart failure. | 26472500 |
| Chronic heart failure, Congestive heart failure | Stem Cell Exhaustion | Parameters associated with poor CD34(+) stem cell mobilization in advanced chronic heart failure (CHF) patients were investigated. | 26472500 |
| Congestive heart failure | Stem Cell Exhaustion | Increased RDW was the only independent predictor of poor CD34(+) stem cell mobilization on multivariable analysis and may serve as a biomarker of poor stem cell mobilization in CHF patients. | 26472500 |
| leukemia | Stem Cell Exhaustion | After allogeneic stem cell transplantation, regulatory T cells are known to mitigate graft versus host disease while probably maintaining a graft versus leukemia effect. | 26473355 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | Effects of conditioning intensity in allogeneic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. | 26475283 |
| B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1, Complement Membrane Attack Complex | Stem Cell Exhaustion | We retrospectively analyzed the outcomes of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) who underwent first allogeneic stem cell transplantation (allo-SCT) at complete remission (CR) with myeloablative conditioning (MAC, n = 31) or reduced-intensity conditioning (RIC, n = 15) between 2001 and 2012. | 26475283 |
| Inflammation | Stem Cell Exhaustion | Plasma levels of a preselected panel miRNA, involved in exercise adaptation processes such as angiogenesis (miR-126, miR-210), inflammation (miR-21, miR-146a), hypoxia/ischemia (miR-21, miR-210), and progenitor cells (miR-150), were quantified by RT-PCR. | 26475583 |
| Angioedema | Stem Cell Exhaustion | Non-myeloablative allogeneic stem cell transplantation: a new treatment option for acquired angioedema? | 26478549 |
| gastrointestinal | Stem Cell Exhaustion | After allogeneic stem cell transplant, severe grade III-IV gastrointestinal (GI) acute GvHD is associated with significant morbidity and mortality, and generally results in poor outcomes. | 26479982 |
| Specialty Type - cancer | Stem Cell Exhaustion | Stem cell transplantation is a treatment option for patients with cancer. | 26482109 |
| Specialty Type - cancer | Stem Cell Exhaustion | We retrospectively analyzed the adverse events occurring within 1 hour after infusion in 460 patients with cancer undergoing stem cell transplantation at the Northwestern University Robert H. Lurie Comprehensive Cancer Center from January 1, 2008 and May 1, 2011. | 26482109 |
| Irritation - emotion | Stem Cell Exhaustion | To describe a little-known therapy-related small-airway phenomenon presumably caused by mucosal irritation in patients undergoing allogeneic stem cell transplantation (allo-SCT). | 26482262 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Presence of a MICA-129Met allele in patients (n = 452) undergoing hematopoietic stem cell transplantation (HSCT) increased the chance of overall survival (hazard ratio [HR] = 0.77, P = 0.0445) and reduced the risk to die due to acute graft-versus-host disease (aGVHD) (odds ratio [OR] = 0.57, P = 0.0400) although homozygous carriers had an increased risk to experience this complication (OR = 1.92, P = 0.0371). | 26483398 |
| Specialty Type - cancer | Stem Cell Exhaustion | Pre-treatment peripheral blood CD146+/CD3- cells (as circulating endothelial cells, CECs), CD34+/CD45- cells (as endothelial progenitor cells, EPCs), and CD133+ cells (as cancer stem cells, CSCs) were measured with flow cytometry. | 26484608 |
| Infancy | Stem Cell Exhaustion | Improved Outcomes of Hematopoietic Stem Cell Transplantation in Patients With Infantile Malignant Osteopetrosis Using Fludarabine-Based Conditioning. | 26485304 |
| Infantile malignant osteopetrosis | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (HSCT) is the only curative treatment for infantile malignant osteopetrosis (IMO), but is associated with a high incidence of adverse outcomes. | 26485304 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We present the case of a 3-year-old female with AML with monosomy 7 and somatic PTPN11 mutation who was refractory to conventional AML chemotherapy but responded to a novel regimen of azacitidine and sorafenib followed by stem cell transplantation. | 26485542 |
| Specialty Type - cancer, Non-Small Cell Lung Carcinoma, Neoplasms | Stem Cell Exhaustion | Here we report that the PI3K/Akt1/IL-6/STAT3 signalling pathway regulates generation and stem cell-like properties of Non-Small Cell Lung Cancer (NSCLC) tumor initiating cells (TICs). | 26486080 |
| Multiple Myeloma | Stem Cell Exhaustion | Early high-dose therapy (HDT), consisting of high-dose melphalan and autologous stem cell transplantation following doublet or triplet novel agent induction, is a preferred management strategy for transplant-eligible myeloma patients. | 26487275 |
| Cytogenetics, Stem cells, Acute lymphocytic leukemia | Stem Cell Exhaustion | B lymphoblastic leukemia is a B progenitor cell neoplasm with a range of immature immunophenotypes and several associated cytogenetic lesions. | 26489677 |
| Laryngeal Squamous Cell Carcinoma | Stem Cell Exhaustion | The role of miR-145 in stem cell characteristics of human laryngeal squamous cell carcinoma Hep-2 cells. | 26490990 |
| Malignant neoplasm of larynx, Specialty Type - cancer | Stem Cell Exhaustion | In this study, we aimed to explore the role of miR-145, which is downregulated in LSCC, on cancer stem cell potency of laryngeal cancer cells. | 26490990 |
| Neoplasms, Secondary Neoplasm, Resistance Process | Stem Cell Exhaustion | Based on these results, we propose that miR-145 might carry crucial roles in LSCC tumorigenesis, prognosis, metastasis, chemoresistance, and recurrence through regulating stem cell properties of tumor cells. | 26490990 |
| Specialty Type - cancer | Stem Cell Exhaustion | Exploring long-term cancer survivors' experiences in the career and financial domains: Interviews with hematopoietic stem cell transplantation recipients. | 26492184 |
| Specialty Type - cancer | Stem Cell Exhaustion | Using semi-structured interviews with 50 hematopoietic stem cell transplantation (HSCT) recipients who were 2 to 22 years post-transplant, this study investigates cancer survivors' interpretations of their economic and work-related experiences during and after treatment. | 26492184 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Steroid-refractory graft-versus-host disease (GvHD) is a complication following an allogeneic stem cell transplantation with limited therapeutic options. | 26492560 |
| Neutropenia | Stem Cell Exhaustion | Filgrastim versus TBO-filgrastim to reduce the duration of neutropenia after autologous hematopoietic stem cell transplantation: TBO, or not TBO, that is the question. | 26493022 |
| Multiple Myeloma | Stem Cell Exhaustion | After a hospital-wide formulary change resulted in the replacement of filgrastim with TBO-filgrastim for all on- and off-label indications, we performed a retrospective comparison of patients with myeloma receiving 200 mg/m(2) melphalan with autologous hematopoietic stem cell transplantation to see whether the type of growth factor used post-transplant made a difference. | 26493022 |
| Specialty Type - cancer, Infectious Lung Disorder | Stem Cell Exhaustion | The aim of this study was to determine clinical and radiographic characteristics of pulmonary infection due to Legionella in persons undergoing treatment for cancer and stem cell transplant (SCT) recipients. | 26496794 |
| Hematologic Neoplasms, Infection, Mycoses | Stem Cell Exhaustion | Radiographic findings were varied-nodular infiltrates mimicking invasive fungal infection were seen only among patients with hematologic malignancy and hematopoietic stem cell transplant (SCT) recipients and were frequently associated with non-pneumophila infections (50% vs 16%; P = 0.0594). | 26496794 |
| Secondary Acute Myeloid Leukemia, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | This report focuses on the adaptive phase I trial design aimed to find the clinically applicable dose for decitabine maintenance treatment after allogeneic hematopoietic stem cell transplantation in patients with higher-risk myelodysplastic syndrome and secondary acute myeloid leukemia. | 26497198 |
| Specialty Type - cancer | Stem Cell Exhaustion | Long non-coding RNA HOTAIR (HOX transcript antisense intergenic RNA) is involved in mesenchymal stem cell fate and cancer biology. | 26497652 |
| Specialty Type - cancer | Stem Cell Exhaustion | Multipotent mesenchymal stem cells or an aggravated epithelial to mesenchymal transition phenotype of a cancer are integrally involved in pathways conferring chemo-resistance. | 26497652 |
| Specialty Type - cancer | Stem Cell Exhaustion | Ubiquitin-specific protease 22 (USP22) is a newly discovered deubiquitinating enzyme and is a cancer stem cell marker that plays a role in tumorigenesis, therapy resistance and cell cycle progression. | 26497847 |
| Adult Glioblastoma | Stem Cell Exhaustion | A novel stem cell culture model of recurrent glioblastoma. | 26498281 |
| Neoplasms | Stem Cell Exhaustion | Brain tumor stem cells (BTSCs) have been implicated in not only initiating GBM but also conferring resistance to therapy. | 26498281 |
| Aspergillosis | Stem Cell Exhaustion | Historically, invasive aspergillosis (IA) has been a major barrier for allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 26501769 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cell property was checked by tumor sphere formation and markers including CD133, Nanog, c-Myc, and KLF4. | 26503334 |
| Aggressive behavior, Neoplasms | Stem Cell Exhaustion | Increased aggressiveness of this tumor, as well as resistance to standard drug therapies, may be associated with the presence of stem cell populations within the tumor. | 26504780 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | Prognostic Value of Cancer Stem Cells Markers in Triple-Negative Breast Cancer. | 26504780 |
| Specialty Type - cancer, Aggressive behavior, Neoplasms, Carcinogenesis | Stem Cell Exhaustion | In conclusion, despite the fact that the presence of the cancer stem cells in the tumor provides important information on its potential aggressiveness, today their detection by immunohistochemistry is not sufficient to confirm their role in carcinogenesis, because specific markers probably are not yet identified. | 26504780 |
| Adult Glioblastoma, biological adaptation to stress | Stem Cell Exhaustion | Ribosomal Proteins RPS11 and RPS20, Two Stress-Response Markers of Glioblastoma Stem Cells, Are Novel Predictors of Poor Prognosis in Glioblastoma Patients. | 26506620 |
| Adult Glioblastoma, Neoplasms | Stem Cell Exhaustion | Glioblastoma stem cells (GSC) co-exhibiting a tumor-initiating capacity and a radio-chemoresistant phenotype, are a compelling cell model for explaining tumor recurrence. | 26506620 |
| Stricture of artery | Stem Cell Exhaustion | Reduced endothelial progenitor cells in extracranial arterial stenosis but not intracranial arterial stenosis. | 26506942 |
| Cardiovascular Diseases, Endothelial dysfunction | Stem Cell Exhaustion | Endothelial progenitor cells (EPCs) are novel markers of endothelial dysfunction and are related to cardiovascular disease. | 26506942 |
| Peripheral Stem Cell Transplantation, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | In the second case, an 11-year-old boy with acute myeloid leukemia underwent peripheral blood stem cell transplantation (PBSCT). | 26508186 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Aggressive strategies, such as eradication of CML stem cells with limited duration and intensive regimens of chemotherapy and TKIs, may be more advantageous in children as a way to avoid lifelong exposure to TKIs and their associated adverse effects. | 26511135 |
| Peripheral Arterial Diseases | Stem Cell Exhaustion | Endothelial progenitor cells as a biological marker of peripheral artery disease. | 26511986 |
| Peripheral Arterial Diseases | Stem Cell Exhaustion | The role of endothelial progenitor cells (EPCs) in peripheral artery disease (PAD) remains unclear. | 26511986 |
| melanoma, senile | Stem Cell Exhaustion | Pluripotent cells-engineered 3D-biologics (PMSB) and control non-3D-biologics were prepared from placenta-based somatic stem cells (PSCs) and inoculated respectively into senile hosts bearing progressive mammary, lung, colon carcinomas and melanoma. | 26512920 |
| Cessation of life | Stem Cell Exhaustion | We evaluated associations of demographic variables (race, ethnicity, language, religion, and diagnosis) with end-of-life characteristics (Phase I enrollment, do-not-resuscitate (DNR) orders, hospice utilization, location of death), and trends in palliative care services delivered to pediatric hematology, oncology, and stem cell transplant (SCT) patients. | 26513237 |
| Carcinoma, Transitional Cell | Stem Cell Exhaustion | We propose that miR-145 may confer stem cell-like properties on urothelial carcinoma cells and thus facilitate differentiation into multiple cell types. | 26514209 |
| Thrombocytosis, Megakaryocytic hyperplasia, Thrombocythemia, Essential | Stem Cell Exhaustion | Essential thrombocythemia (ET) is a clonal hemopoietic stem cell myeloproliferative neoplasm characterized by persistent thrombocytosis along with megakaryocytic hyperplasia. | 26514532 |
| Malignant neoplasm of lung | Stem Cell Exhaustion | Secretome of human bone marrow mesenchymal stem cells: an emerging player in lung cancer progression and mechanisms of translation initiation. | 26515338 |
| Specialty Type - cancer | Stem Cell Exhaustion | Accumulating data allocate a central role for the cancer microenvironment including mesenchymal stem cells (MSCs) in acquisition of drug resistance and disease relapse. | 26515338 |
| How Often Shortness of Breath, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | A 50-year-old man with a history of myelodysplastic syndrome status postallogeneic haematopoietic stem cell transplantation (HSCT) in July 2013 presented in January 2014 with a 6-week history of worsening shortness of breath and dry cough. | 26516247 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | CD44 has been identified as a cancer stem cell (CSC) biomarker in various malignancies. | 26517627 |
| Prostate carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cell markers in prostate cancer: an immunohistochemical study of ALDH1, SOX2 and EZH2. | 26517640 |
| Specialty Type - cancer, Aggressive behavior, Adenocarcinoma of prostate, Prostate carcinoma | Stem Cell Exhaustion | SOX2 showed a statistically significant correlation with lymphovascular invasion only (p = 0.018) in both univariate and multivariate analyses.Cancer stem cell markers are variably expressed in prostate adenocarcinoma and immunohistochemical staining for ALDH1 and EZH2 may have a role in predicting tumour aggressiveness before treatment of prostate cancer. | 26517640 |
| Coinfection | Stem Cell Exhaustion | HHV-6 infection after allogeneic hematopoietic stem cell transplantation: From chromosomal integration to viral co-infections and T-cell reconstitution patterns. | 26518057 |
| Inflammation | Stem Cell Exhaustion | Telomerase Deficiency Causes Alveolar Stem Cell Senescence-associated Low-grade Inflammation in Lungs. | 26518879 |
| Impaired | Stem Cell Exhaustion | In this report, we show that knock-out (KO) of the mouse gene Terc or Tert causes pulmonary alveolar stem cell replicative senescence, epithelial impairment, formation of alveolar sacs, and characteristic inflammatory phenotype. | 26518879 |
| Inflammation, Deficiency | Stem Cell Exhaustion | Our data demonstrate for the first time that telomerase deficiency triggers alveolar stem cell replicative senescence-associated low-grade inflammation, thereby driving pulmonary premature aging, alveolar sac formation, and fibrotic lesion. | 26518879 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Immune responses to WT1 in patients with AML or MDS after chemotherapy and allogeneic stem cell transplantation. | 26519872 |
| Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Here, we analyzed expression of WT1 in 226 peripheral blood and bone marrow samples from patients with acute myeloid leukemia or myelodysplastic syndrome (AML/MDS) before and after allogeneic stem cell transplantation (SCT). | 26519872 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Impairment of PI3K/AKT and WNT/b-catenin pathways in bone marrow mesenchymal stem cells isolated from patients with myelodysplastic syndromes. | 26521017 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Multiple congenital anomalies | Stem Cell Exhaustion | Bone marrow mesenchymal stem cells (BM-MSCs) exhibit multiple abnormalities in myelodysplastic syndromes (MDS), including impaired proliferative and clonogenic capacity, altered morphology, increased senescence, impaired immunoregulatory properties, and reduced hematopoietic support capacity. | 26521017 |
| Specialty Type - cancer, Carcinoma | Stem Cell Exhaustion | Carcinoma cells within larger VI areas expressed significantly higher levels of podoplanin, cancer stem cell marker (P = 0.039); higher numbers of CD34(+) microvessels (P = 0.009), CD204(+) macrophages (P = 0.026), and a-SMA(+) myofibroblasts (P = 0.056) were present within larger VI areas than within smaller VI ones. | 26521256 |
| Neoplasm Metastasis, Specialty Type - cancer | Stem Cell Exhaustion | Our results indicate that larger VI areas are a predictor for recurrence in lung SCC; also, within the larger blood vessel, cancer stem cells and abundant stromal cells can create a more favorable microenvironment for tumor metastasis. | 26521256 |
| Concomitant Medication Submission Domain, Degenerative polyarthritis | Stem Cell Exhaustion | To define whether good manufacturing practice (GMP)-clinical grade adipose stem cell (ASC)-derived conditioned medium (CM) is as effective as GMP-ASC in modulating inflammatory and catabolic factors released by both osteoarthritis (OA) chondrocytes or synoviocytes. | 26521751 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | alemtuzumab as graft-versus-host disease (GVHD) prophylaxis for matched unrelated donor stem cell transplantations. | 26524732 |
| Aplastic Anemia | Stem Cell Exhaustion | BM cellularity in ITP may represent an impairment and/or lower responsiveness of pluripotent hematopoietic stem cells, not limited to the megakaryocyte (MgK) -platelet axis, to endogenous TPO, because recent evidence shows that TPO-RA can successfully restore hematopoiesis in aplastic anemia. | 26524893 |
| Osteoporosis, Frailty | Stem Cell Exhaustion | Association Between Circulating Osteogenic Progenitor Cells and Disability and Frailty in Older Persons: The Nepean Osteoporosis and Frailty Study. | 26525092 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | A Phase I Trial of High-Dose Chemotherapy Combining Topotecan plus Cyclophosphamide with Hematopoietic Stem Cell Transplantation for Ovarian Cancer: The ITOV 01bis Study. | 26528705 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | Dose-intensive chemotherapy with hematopoietic stem cell transplantation has been evaluated as a salvage treatment for recurrent ovarian cancer, but its benefit has not yet been demonstrated. | 26528705 |
| Toxic effect | Stem Cell Exhaustion | Although hematopoietic toxicities were overcome by peripheral blood stem cell transplantation, superior nonhematological toxicities were observed as compared to the initial trial. | 26528705 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Outcomes of Allogeneic Stem Cell Transplantation in Elderly Patients with Acute Myeloid Leukemia: A Systematic Review and Meta-analysis. | 26529178 |
| Toxic effect, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | A large number of elderly patients with acute myeloid leukemia (AML) are not offered treatments with curative intent, such as allogeneic stem cell transplantation (SCT), because of fears of toxicity and perceived futility of intensive treatment. | 26529178 |
| Malignant tumor of cervix, Specialty Type - cancer | Stem Cell Exhaustion | Clinical significance of Gremlin 1 in cervical cancer and its effects on cancer stem cell maintenance. | 26530461 |
| Neoplasms | Stem Cell Exhaustion | Recent studies suggest that latexin (Lxn) expression is involved in stem cell regulation and that it plays significant roles in tumor cell migration and invasion. | 26530530 |
| Multiple Myeloma | Stem Cell Exhaustion | Evaluation of low-dose thalidomide as induction and maintenance therapy in patients with multiple myeloma not eligible for stem cell transplantation. | 26531225 |
| Multiple Myeloma | Stem Cell Exhaustion | The role of thalidomide in induction and long-term maintenance therapy in patients with multiple myeloma not eligible for stem cell transplantation remains unclear. | 26531225 |
| Childhood Breast Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Breast cancer samples contained about 2.7% of cancer stem like SP cells which possessed elevated mRNA expression of stem cell proteins Oct-4, EpCAM and ABC transporter ABCG2, essential for the maintenance of SP cells. | 26537077 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Elevated survivin mediated multidrug resistance and reduced apoptosis in breast cancer stem cells. | 26537077 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease (GVHD) complicates half of hematopoietic stem cell transplants (HCT), and the gastrointestinal tract is commonly affected. | 26537485 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Normal karyotype acute myeloid leukemia patients with CEBPA double mutation have a favorable prognosis but no survival benefit from allogeneic stem cell transplant. | 26537612 |
| Neoplastic Cell Transformation | Stem Cell Exhaustion | The SRY (sex determining region Y)-box 2 gene, SOX2, is an essential embryonic stem cell gene involved in prostate tumorigenesis. | 26540632 |
| Primordial follicles | Stem Cell Exhaustion | Data has accumulated in support of ovarian stem cells (OSCs) proliferation, maintenance in culture, formation of germ cell nests and differentiation into oocytes and primordial follicle assembly using different strategies. | 26542369 |
| Neoplasms, Prostate carcinoma, Specialty Type - cancer, Usual Severity Pain | Stem Cell Exhaustion | The secondary endpoints included the tumor response rate (RECIST 1.0), safety (National Cancer Institute Common Terminology Criteria for Adverse Events, version 3.0), quality of life (Functional Assessment of Cancer Therapy-Prostate [FACT-P]), pain (Present Pain Intensity [PPI] scale), prostate-specific antigen (PSA) parameters, including time to PSA progression (TTPP) according to Prostate Cancer Clinical Trials Working Group criteria, and serial enumeration of circulating endothelial cells (CECs) and endothelial progenitor cells (CEPs). | 26542984 |
| Kidney Failure, Chronic, Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Human mesenchymal stem cells alter the gene profile of monocytes from patients with Type 2 diabetes and end-stage renal disease. | 26544198 |
| Adult Glioblastoma | Stem Cell Exhaustion | Here we used MGMT-expressing glioblastoma stem cells (GSC) lines as a model for investigating the molecular mechanism underlying TMZ resistance, while aiming to explore a new treatment strategy designed to possibly overcome resistance to the clinically relevant dose of TMZ (35 mM). | 26546412 |
| Autosomal recessive inheritance, Dyskeratosis Congenita | Stem Cell Exhaustion | A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition. | 26546739 |
| Vascular System Injuries | Stem Cell Exhaustion | The number of circulating endothelial cells (CEC) and endothelial progenitor cells (EPC) might reflect the balance between vascular injury and repair. | 26552487 |
| Bronchopleural Fistula, CTCAE | Stem Cell Exhaustion | This preliminary study showed that bronchoscopic application of autologous adipose-derived stem cells is a feasible, safe and effective procedure for treating bronchopleural fistula. | 26552766 |
| Neoplasms | Stem Cell Exhaustion | This case supports the hypothesis that these tumors share a common progenitor cell, which could be the folliculostellate cell. | 26553184 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Chronic myeloid leukemia (CML) originates from normal hematopoietic stem cells acquiring Philadelphia chromosome (Ph) to generate BCR-ABL fusion gene whose protein product has deregulated tyrosine kinase activity. | 26554155 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Modulating the Growth and Imatinib Sensitivity of Chronic Myeloid Leukemia Stem/Progenitor Cells with Pullulan/MicroRNA Nanoparticles In Vitro. | 26554155 |
| Specialty Type - cancer, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Delivery of microRNA (miRNA) using non-viral vectors has been utilized to inhibit various cancer cells; however, the efficacy of this approach to target CML stem/progenitor cells has not been elucidated. | 26554155 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Taken together, we have therefore demonstrated that the delivery of miR-181a using Ps to CML stem/progenitor cells leads to their growth inhibition and enhancement of IM sensitivity, which will possibly be beneficial to CML treatment. | 26554155 |
| Facet joint structure | Stem Cell Exhaustion | Isolation and Characterization of Human Mesenchymal Stem Cells From Facet Joints and Interspinous Ligaments. | 26555840 |
| Facet joint structure | Stem Cell Exhaustion | A descriptive in vitro study on isolation and differentiation of human mesenchymal stem cells (MSCs) derived from the facet joints and interspinous ligaments. | 26555840 |
| Inflammatory disorder | Stem Cell Exhaustion | Mesenchymal stem cells are known to exert immunomodulatory effects in inflammatory diseases. | 26558442 |
| Rheumatoid Arthritis | Stem Cell Exhaustion | Interleukin 17 inhibits progenitor cells in rheumatoid arthritis cartilage. | 26558442 |
| Rheumatoid Arthritis, Inflammation | Stem Cell Exhaustion | Here, we studied progenitor cells from RA cartilage (RA-CPCs) that are positive for IL-17 receptors to determinate the effects of inflammation on their chondrogenic potenial. | 26558442 |
| Multiple Myeloma | Stem Cell Exhaustion | CXCR4-targeted radiotherapy with pentixather appears to be a promising novel treatment option in combination with cytotoxic chemotherapy and autologous stem cell transplantation, especially for patients with advanced multiple myeloma. | 26564323 |
| Acute leukemia | Stem Cell Exhaustion | Peripheral blood stem cell graft compared to bone marrow after reduced intensity conditioning regimens for acute leukemia: a report from the ALWP of the EBMT. | 26565001 |
| leukemia, Acute leukemia | Stem Cell Exhaustion | Patients who underwent reduced intensity conditioning regimen allogeneic hematopoietic stem cell transplantation from 2000 to 2012 for acute leukemia, and who were reported to the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation were included in the study. | 26565001 |
| Breast Carcinoma, Neoplasms, Childhood Breast Carcinoma | Stem Cell Exhaustion | BRCAmut tumors bear stem cell characteristics displaying a distinct cell adhesion molecule profile characterized by high expression of CDH1 and CLDN4 according to public gene expression data set analysis, and higher claudin-3 expression as detected by IHC; thus, BRCAmut breast carcinomas are not identical with the previously identified claudin-low subtype of breast cancer. | 26566278 |
| Specialty Type - cancer | Stem Cell Exhaustion | However, the molecular mechanisms that underlie modulation of cancer stem cells (CSCs) in NPC remain unclear. | 26568302 |
| Lymphoma | Stem Cell Exhaustion | Thiotepa-based high-dose therapy for autologous stem cell transplantation in lymphoma: a retrospective study from the EBMT. | 26569093 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | Clinical information about thiotepa-based autologous stem cell transplantation (auto-SCT) outside the primary central nervous system lymphoma (PCNSL) field is sparse. | 26569093 |
| Specialty Type - cancer | Stem Cell Exhaustion | Primary cultures of mucin- and mixed-IHCCA were characterized by a different pattern of expression of cancer stem cell markers, and by a different drug sensitivity. | 26571380 |
| Specialty Type - cancer | Stem Cell Exhaustion | Aldehyde dehydrogenase isoform 1 (ALDH1) has been shown to be a marker of cancer stem cells (CSCs). | 26572760 |
| Neoplasms | Stem Cell Exhaustion | These stem cells may be responsible for tumour perpetuation as well as local and distant invasion. | 26572760 |
| diabetic | Stem Cell Exhaustion | We have evaluated the cellularity and frequency of osteogenic mesenchymal stem cells (MSCs) in bone marrow from 54 diabetic patients (12 with type 1 and 42 with type 2) with tibial non-unions. | 26572889 |
| diabetic | Stem Cell Exhaustion | We recommend that diabetic patients be treated with an increased number of progenitor cells by increasing the bone marrow aspiration volume. | 26572889 |
| MS gene | Stem Cell Exhaustion | Oligodendrocyte progenitor cell (OPC) differentiation is an important therapeutic target to promote remyelination in multiple sclerosis (MS). | 26576485 |
| Acute myocardial infarction | Stem Cell Exhaustion | The chemokine receptor CXCR4 has emerged as a therapeutic target after acute myocardial infarction (AMI), because of its role in inflammatory and progenitor cell recruitment. | 26577262 |
| Craniosynostosis | Stem Cell Exhaustion | Data from patients treated with CRS alone (N = 18) or CRS and HIO (N = 62) were used to estimate the baseline platelet count (PLT0), rate constants for platelet maturation (k tr ) and platelet random destruction (k s ), feedback on progenitor cell proliferation (g), and the drug-specific model parameters (a, b). | 26577587 |
| Schizophrenia, Deficit | Stem Cell Exhaustion | In order to gain insight into the possible neurobiological mechanisms of myelin deficit, we determined the messenger RNA (mRNA) expression profile of laser captured cells that were immunoreactive for 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), a marker for oligodendrocyte progenitor cells (OPCs) in addition to differentiating and myelinating oligodendrocytes, in the white matter of the prefrontal cortex in schizophrenia subjects. | 26585218 |
| Cartilage | Stem Cell Exhaustion | To compare the clinical and radiologic efficacy of adipose-derived stem cells (ADSCs) with fibrin glue and microfracture (MFX) versus MFX alone in patients with symptomatic knee cartilage defects. | 26585585 |
| Having administered | Stem Cell Exhaustion | PTH Induces Systemically Administered Mesenchymal Stem Cells to Migrate to and Regenerate Spine Injuries. | 26585691 |
| Fracture | Stem Cell Exhaustion | Parathyroid hormone (PTH) was shown to induce fracture repair in animals by activating mesenchymal stem cells (MSCs). | 26585691 |
| Natural Killer Cells | Stem Cell Exhaustion | Natural killer cell tumors can be broadly divided by origin into mature-cell and progenitor-cell types. | 26585973 |
| Atrophic | Stem Cell Exhaustion | Furthermore, in vitro, AGEs (in a dose-dependent manner) reduced myotube diameters (myotube atrophy) and induced Atrogin-1 protein expression in myotubes differentiated from both mouse myoblasts and primary human skeletal muscle-derived progenitor cells. | 26586640 |
| Malignant Neoplasms | Stem Cell Exhaustion | The Shreveport Myeloma Experience: Survival, Risk Factors and Other Malignancies in the Age of Stem Cell Transplantation. | 26588024 |
| Myocardial Ischemia | Stem Cell Exhaustion | Smoking impairs and circulating stem cells favour the protective effect of the T allele of the connexin37 gene in ischemic heart disease--A multinational study. | 26588185 |
| Mucopolysaccharidoses | Stem Cell Exhaustion | A Case of a Bilateral Cicatricial Upper Eyelid Entropion After Hematopoietic Stem Cell Transplantation in Mucopolysaccharidosis Type I. | 26588207 |
| conjunctiva, Corneal erosion, Excessive tearing, Mucopolysaccharidoses | Stem Cell Exhaustion | The authors report a clinical case of severe bilateral cicatricial entropion of the upper eyelids, leading to recurrent conjunctival infections, corneal erosion, persistent epiphora, and a major decline in life quality in a 7-year-old boy with mucopolysaccharidosis type I who underwent hematopoietic stem cell transplantation at 1.6 years old. | 26588207 |
| Lymphopenia, Hyposplenia | Stem Cell Exhaustion | E2A-HLF expression in B-cell progenitors induced hyposplenia and lymphopenia, whereas expression in hematopoietic stem/progenitor cells was embryonic lethal. | 26588248 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Monosomal karyotype as an adverse prognostic factor in patients with acute myeloid leukemia treated with allogeneic hematopoietic stem-cell transplantation in first complete remission: a retrospective survey on behalf of the ALWP of the EBMT. | 26589909 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Despite the overall benefit from allogeneic hematopoietic stem cell transplantation observed in patients with poor cytogenetic risk acute myeloid leukemia in first complete remission, the precise effect of this procedure for different poor-risk subtypes has not been fully analyzed. | 26589909 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | In summary, monosomal karyotype arises as a strong negative prognostic feature in acute myeloid leukemia also in patients who undergo allogeneic hematopoietic stem cell transplantation in first complete remission, stressing the need to develop additional pre- and post-transplantation strategies aimed at improving overall results. | 26589909 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Nonetheless, allogeneic hematopoietic stem cell transplantation in early phase is currently the best therapy for this very poor-risk acute myeloid leukemia subtype. | 26589909 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | CD4+ T cells from patients with acute myeloid leukemia inhibit the proliferation of bone marrow-derived mesenchymal stem cells by secretion of miR-10a. | 26590574 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The abnormality of bone marrow-derived mesenchymal stem cells (BM-MSCs) has been reported to contribute to the pathogenesis of acute myeloid leukemia (AML). | 26590574 |
| Neutropenia | Stem Cell Exhaustion | Use of proton pump inhibitors in hematopoietic stem cell transplantation does not increase the frequency of febrile neutropenia. | 26592835 |
| Febrile Neutropenia, Infection | Stem Cell Exhaustion | Despite the fact that proton pump inhibitor (PPI) use is a risk factor for infections in heterogeneous groups of patients, there are only a limited data related to PPI use and febrile neutropenic episodes (FNEs) in hematopoietic stem cell transplantation (HSCT) patients. | 26592835 |
| Multiple Myeloma | Stem Cell Exhaustion | High-dose melphalan plus autologous stem-cell transplantation (ASCT) is the standard approach in transplant-eligible patients with newly diagnosed myeloma. | 26596670 |
| Colorectal Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Lgr5 Methylation in Cancer Stem Cell Differentiation and Prognosis-Prediction in Colorectal Cancer. | 26599100 |
| Colorectal Carcinoma | Stem Cell Exhaustion | Leucine-rich-repeat-containing G-protein-coupled receptor 5 (lgr5) is a candidate marker for colorectal cancer stem cells (CSC). | 26599100 |
| Hereditary Diseases | Stem Cell Exhaustion | Characterization of neurons from immortalized dental pulp stem cells for the study of neurogenetic disorders. | 26599327 |
| Mucopolysaccharidoses, Sleep Apnea, Obstructive, Sleep Apnea Syndromes, Mucopolysaccharidosis I | Stem Cell Exhaustion | Obstructive sleep apnea syndrome after hematopoietic stem cell transplantation in children with mucopolysaccharidosis type I. Obstructive sleep apnea syndrome (OSAS) is very common in mucopolysaccharidosis I (MPS I). | 26602600 |
| Mucopolysaccharidosis I | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (HSCT) is the preferred treatment for patients with severe MPS I diagnosed early in life. | 26602600 |
| Lymphoma, T-Cell, Cutaneous | Stem Cell Exhaustion | Hematopoietic stem cell transplantation for cutaneous T-cell lymphoma: Summary of 11 cases from two facilities in Japan and Brazil. | 26602996 |
| TSPYL2 gene, Lymphoma, T-Cell, Cutaneous | Stem Cell Exhaustion | Some patients with cutaneous T-cell lymphoma (CTCL) show a miserable clinical course and the only option that can induce long-term remission for advanced CTCL may be hematopoietic stem cell transplantation (HSCT). | 26602996 |
| Pneumocystis jiroveci pneumonia | Stem Cell Exhaustion | Retrospective review of intravenous pentamidine for Pneumocystis pneumonia prophylaxis in allogeneic hematopoietic stem cell transplantation. | 26606757 |
| Opportunistic Infections | Stem Cell Exhaustion | Patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) are at risk of numerous opportunistic infections. | 26606757 |
| Lipolysis, Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | We characterised subcutaneous abdominal adipose tissue by examining stromal cell populations by 13 colour flow cytometry, measuring expression of adipogenesis genes in the progenitor cell fraction and determining lipolysis and adipose secretion of inflammatory proteins in 14 non-obese men with type 2 diabetes and 13 healthy controls matched for age, sex, body weight and total fat mass. | 26607638 |
| Hypertrophy, Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | We show that a major phenotype of white adipose tissue in non-obese individuals with type 2 diabetes is adipocyte hypertrophy, which may be mediated by an impaired adipogenic capacity in progenitor cells. | 26607638 |
| Kidney Diseases, Communicable Diseases | Stem Cell Exhaustion | Nephropathy due to BK virus (BKV) infection is an evolving challenge in patients undergoing hematopoietic stem cell transplantation (HSCT). | 26608093 |
| Steroid-Refractory Pneumonitis, Acute GVH disease | Stem Cell Exhaustion | Bone marrow-derived mesenchymal stem cells (JR-031) for steroid-refractory grade III or IV acute graft-versus-host disease: a phase II/III study. | 26608364 |
| Graft-vs-Host Disease, Steroid-Refractory Pneumonitis, Acute GVH disease | Stem Cell Exhaustion | Following a phase I/II study using mesenchymal stem cells (MSCs; JR-031) for steroid-refractory grade II or III acute graft-versus-host disease (aGVHD), a phase II/III study using the cells focused on steroid-refractory grade III or IV aGVHD was conducted. | 26608364 |
| Endometrial Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Immunohistochemical expression of cancer stem cell related markers CD44 and CD133 in endometrial cancer. | 26608413 |
| Behavior of tumor, Endometrial Carcinoma, Specialty Type - cancer, Carcinogenesis | Stem Cell Exhaustion | The goal of this study was to detect the presence of cancer stem cell markers CD44 and CD133 in immunohistochemically stained samples of endometrial cancer and correlate their expression with clinicopathological variables to identify the impact of CD44 or CD133 expression on tumor behavior and endometrial carcinogenesis. | 26608413 |
| Pregnancy Complications, Infectious, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The patient successfully underwent stem cell transplantation with continuing antifungal treatment and finally completely recovered from both the AML and infectious complications. | 26608844 |
| Liver carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells in hepatocellular carcinoma--an immunohistochemical study with histopathological association. | 26609030 |
| Liver carcinoma, Hollings Cancer Center, Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cells (CSCs) may be responsible for tumour recurrence and resistance to chemotherapy in hepatocellular carcinoma (HCC). | 26609030 |
| Neoplasms | Stem Cell Exhaustion | Immunohistochemical staining for the LCSC marker EpCAM (epithelial cell adhesion molecule), liver progenitor cell (LPC) markers CK19 (cytokeratin 19) and neural cell adhesion molecule (NCAM) were performed and were associated with histological features of tumour behaviour. | 26609030 |
| Hematological Disease | Stem Cell Exhaustion | Allogeneic stem cell transplantation is commonly used in the treatment of younger patients with severe hematological diseases, and endothelial cells seem to be important for the development of several posttransplant complications. | 26609191 |
| Acute lymphocytic leukemia, Childhood Non-Hodgkin Lymphoma, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | A total of 14,951 patients with acute myeloid leukemia, acute lymphocytic leukemia, myelodysplastic syndrome and non-Hodgkin lymphoma transplanted with peripheral blood stem cells or bone marrow grafts were included. | 26611475 |
| Lymphoma | Stem Cell Exhaustion | Increased efficacy of intermediate-dose cytarabine + G-CSF compared to DHAP + G-CSF for stem cell mobilization in patients with lymphoma: an analysis by the polish lymphoma research group. | 26611854 |
| Lymphoma | Stem Cell Exhaustion | Salvage regimens, like DHAP (dexamethasone, cytarabine, and cisplatin) are frequently used for stem cell mobilization in lymphoma. | 26611854 |
| Lymphoma | Stem Cell Exhaustion | We conclude that stem cell mobilization using ID-AraC is associated with a significantly higher efficacy than DHAP, allowing for collection of the transplant material in almost all patients with lymphoma. | 26611854 |
| Graft-vs-Host Disease, Stable chronic Graft vs Host Disease | Stem Cell Exhaustion | In a retrospective analysis of 102 allogeneic hematopoietic stem cell transplant (HSCT) patients, incidences of overall and severe aGvHD (>IIdeg), cGvHD as well as overall and severe (CTC >IIdeg) GI-toxicities were compared between GvHD prophylaxis containing EC-MPS vs. MMF or MTX (control group). | 26613546 |
| Neoplasms, Fibrous Tissue | Stem Cell Exhaustion | Immunohistochemical evaluation of stem cell markers and signal transducer and activator of transcription 6 (STAT6) in solitary fibrous tumors. | 26617768 |
| Neoplasms | Stem Cell Exhaustion | To analyze the immunophenotype of SFT for the identification of specific diagnostic markers and the cell of origin of this tumor, we performed an immunohistochemical study of stem cell markers [aldehyde dehydrogenase 1 (ALDH1), CD29, CD44, CD133, and nestin] and signal transducer and activator of transcription 6 (STAT6) in 18 cases of SFT. | 26617768 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Cells with unique phenotypes and stem cell-like properties have been found to exist in breast cancer. | 26617852 |
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Acute leukemia | Stem Cell Exhaustion | Impact of conditioning with TBI in adult patients with T-cell ALL who receive a myeloablative allogeneic stem cell transplantation: a report from the acute leukemia working party of EBMT. | 26618548 |
| Adult T-Cell Lymphoma/Leukemia, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (allo-SCT) is a therapeutic option for adult patients with T-cell ALL (T-ALL). | 26618548 |
| Exfoliative dermatitis, Angioimmunoblastic Lymphadenopathy, Pruritus | Stem Cell Exhaustion | We report a case of a patient with angioimmunoblastic T-cell lymphoma presenting initially with pruritus and saggy skin, which later progressed into erythroderma despite chemotherapy; the disease eventually resolved with autologous stem cell transplant. | 26620295 |
| LIPC gene | Stem Cell Exhaustion | For HL, the indication is restricted to treatment after autologous stem cell transplantation (ASCT) or after at least two previous therapies when ASCT or multiagent chemotherapy is not a treatment option. | 26621039 |
| Hodgkin Disease | Stem Cell Exhaustion | For Hodgkin lymphoma, brentuximab vedotin should only be used after autologous stem cell transplantation or following at least two prior therapies when transplantation or multiagent chemotherapy is not a treatment option. | 26621039 |
| Specialty Type - cancer, Ductal Breast Carcinoma | Stem Cell Exhaustion | Clinicopathological Significance of CD133 and ALDH1 Cancer Stem Cell Marker Expression in Invasive Ductal Breast Carcinoma. | 26625750 |
| Specialty Type - cancer, Ductal Breast Carcinoma | Stem Cell Exhaustion | We investigated the possible correlation between cancer stem cell (CSC) markers (CD133, and ALDH1) in invasive ductal breast carcinomas with some clinicopathological parameters. | 26625750 |
| Specialty Type - cancer, Ductal Breast Carcinoma | Stem Cell Exhaustion | To assess the correlation between expression of cancer stem cell (CSC) markers (CD133, and ALDH1) and clinicopathological parameters of invasive ductal breast carcinomas. | 26625750 |
| Amyloidosis | Stem Cell Exhaustion | The impact of dialysis on the survival of patients with immunoglobulin light chain (AL) amyloidosis undergoing autologous stem cell transplantation. | 26627634 |
| Kidney Failure, Acute | Stem Cell Exhaustion | Acute renal failure requiring dialysis is associated with high mortality during autologous stem cell transplantation (ASCT). | 26627634 |
| Lupus Nephritis | Stem Cell Exhaustion | Human embryonic stem cell-derived mesenchymal cells preserve kidney function and extend lifespan in NZB/W F1 mouse model of lupus nephritis. | 26628350 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | GBM is essentially incurable and its resistance to therapy is attributed to a subpopulation of cells called glioma stem cells (GSCs). | 26629530 |
| Veins, Hyperemia, Atherosclerosis | Stem Cell Exhaustion | Effect of Extended-Release Niacin on Carotid Intima Media Thickness, Reactive Hyperemia, and Endothelial Progenitor Cell Mobilization: Insights From the Atherosclerosis Lesion Progression Intervention Using Niacin Extended Release in Saphenous Vein Grafts (ALPINE-SVG) Pilot Trial. | 26630643 |
| Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | Expressions of stem cell transcription factors Nanog and Oct4 in renal cell carcinoma tissues and clinical significance. | 26631537 |
| Renal Cell Carcinoma Pathway, Refractory Cytopenia of Childhood | Stem Cell Exhaustion | We aimed to detect the expressions of stem cell transcription factors Nanog and Oct4 in renal cell carcinoma (RCC) tissues. | 26631537 |
| Leukemia, Myelocytic, Acute, Myeloid neoplasm | Stem Cell Exhaustion | Allogeneic stem cell transplantation (allo-HCT) represents the most effective immunotherapy for acute myeloid leukemia (AML) and myeloid malignancies. | 26631751 |
| Experimental Organism Basal Cell Carcinoma | Stem Cell Exhaustion | It is unknown whether the histologic subtypes of basal cell carcinoma (BCC) arise from a common progenitor cell or whether other factors play a role in their development. | 26631769 |
| Fever, Leukemia, Myelocytic, Acute, Pichia kudriavzevii | Stem Cell Exhaustion | During hospitalization for neutropenic fever, a 19-year-old man with acute myeloid leukemia, who underwent hematopoietic stem cell transplantation, developed a generalized folliculocentric eruption following initiation of antifungal therapy for newly diagnosed C. krusei fungemia. | 26632935 |
| Diabetes, Coronary heart disease | Stem Cell Exhaustion | Aging and diabetes were the major risk factors that influence the level and function of bone marrow resident progenitor cells in patients with coronary heart disease undergoing CABG. | 26634486 |
| leukemia, Haploidentical Hematopoietic Cell Transplantation | Stem Cell Exhaustion | Treatment of childhood leukemia with haploidentical hematopoietic stem cell transplantation using parent as donor: a single-center study of 111 case. | 26636526 |
| Pancreatic carcinoma | Stem Cell Exhaustion | In this study, we measured ROR in 61 paired cancerous and noncancerous tissue samples by qRT-PCR and investigated the biological role of ROR on the phenotypes of pancreatic cancer stem cells (PCSCs) in vitro and in vivo. | 26636540 |
| Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin | Stem Cell Exhaustion | The role of autologous hematopoietic stem cell transplantation (ASCT) in the management of non-Hodgkin's lymphoma (NHL) is evolving, in the era of novel agents. | 26637704 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | PV-T tumors were associated with higher expression of two proneural and cancer stem cell genes, NOTCH1 (p = 0.028) and PROM1 (p = 0.033) while PV-FP tumors were characterized by high expression of a mesenchymal gene, CHI3L1 (p = 0.006). | 26637806 |
| Teratoma | Stem Cell Exhaustion | Most teratomas contained cells differentiating into astrocytes positive for nestin, a neural stem cell marker. | 26638157 |
| Diabetes Mellitus | Stem Cell Exhaustion | Fetal Pancreatic Stem-Cell Transplant in Patients With Diabetes Mellitus. | 26640941 |
| Diabetes Mellitus | Stem Cell Exhaustion | To determine the efficacy of fetal stem cell transplant for treating patients with diabetes mellitus types 1 and 2. | 26640941 |
| Diabetes Mellitus | Stem Cell Exhaustion | Five patients with diabetes mellitus type 1 and 5 patients with diabetes mellitus type 2 (aged 18-56 years) received a fetal pancreatic stem-cell transplant (cells were 16-18 wk gestation) performed by intravenous infusion at 50 mL/hour. | 26640941 |
| Diabetes Mellitus | Stem Cell Exhaustion | In patients with diabetes mellitus type 1, fetal stem-cell transplant led to a significant increase in C-peptide levels, from 0.09 +- 0.01 ng/mL to 0.20 +- 0.07 ng/mL, after 3 months (P < .008). | 26640941 |
| Diabetes | Stem Cell Exhaustion | Treatment with fetal pancreatic stem cells may be beneficial for treating patients with type 1 or type 2 diabetes. | 26640941 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | Preemptive antiviral therapy for CMV infection in allogeneic stem cell transplant recipients guided by the viral doubling time in the blood. | 26642339 |
| PAFAH1B1 wt Allele, leukemia | Stem Cell Exhaustion | Leukemia stem cells (LSC) in MDS might be contained in those cells. | 26642704 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | The optimal treatment for use as a bridge to allogeneic hematopoietic stem cell transplantation at the decision for transplantation has not been established in patients with myelodysplastic syndrome (MDS). | 26643559 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Despite the recent evidence of the existence of myelodysplastic syndrome (MDS) stem cells in 5q-MDS patients, it is unclear whether haematopoietic stem cells (HSCs) could also be the initiating cells in other MDS subgroups. | 26643973 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Stem cell transplantation for acute myeloid leukemia with pulmonary and cerebral mucormycosis. | 26645867 |
| Zygomycosis, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We retrospectively evaluated the efficacy of stem cell transplantation for a pediatric patient with refractory acute myeloid leukemia (AML) who developed mucormycosis. | 26645867 |
| Zygomycosis, Hematological Disease | Stem Cell Exhaustion | Stem cell transplantation could reduce the mortality of patients with hematologic disease who develop mucormycosis. | 26645867 |
| Specialty Type - cancer, Squamous cell carcinoma | Stem Cell Exhaustion | CD44v3+/CD24- cells possess cancer stem cell-like properties in human oral squamous cell carcinoma. | 26647656 |
| Specialty Type - cancer, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Cancer stem cells (CSCs) or cancer stem cell-like cells (CSC-LCs) are a minority population of cells that relate to tumor progression, metastasis and drug resistance. | 26647656 |
| Hollings Cancer Center, Neoplasms | Stem Cell Exhaustion | Liver progenitors or stem cells could be a potential therapy for HCC treatment since they migrate toward tumors. | 26647726 |
| Passive Cutaneous Anaphylaxis | Stem Cell Exhaustion | The expression of 6 miRs that have been previously reported to be downregulated in PCa stem cells were examined in a total of 32 recurrent and 36 non-recurrent PCa samples, and let-7a was substantially decreased in the recurrent PCa. | 26648141 |
| Hypoxia | Stem Cell Exhaustion | Though recent studies have revealed that stem cells of many tissues are harbored in hypoxic microenvironment, little is known about the relationship between hypoxia and intestinal crypt base, where intestinal stem cells are supposed to exist. | 26648507 |
| Thoracic Injuries, Traumatic Brain Injury, Traumatic | Stem Cell Exhaustion | To determine the impact of traumatic brain injury (TBI) and chest trauma (CT) on the number of peripheral blood (PB) stem cells in affected patients in comparison to normal controls. | 26649467 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Presence of B haplotype KIR in donors is associated with a lower relapse risk for acute myeloid leukemia (AML) after hematopoietic stem cell transplants (HSCT). | 26649563 |
| Post-Traumatic Stress Disorder | Stem Cell Exhaustion | Quality of life and mood predict posttraumatic stress disorder after hematopoietic stem cell transplantation. | 26650840 |
| Arterial calcification | Stem Cell Exhaustion | At the cellular level, there was a greater presence of pericytes in OM+ compared with OM- lesions (5.59 +- 1.09 vs. 2.42 +- 0.58, percentage of area staining [region of interest]; p = .04); in vitro, pericytes were able to inhibit the osteoblastic differentiation of human mesenchymal stem cells, suggesting that they are involved in regulating arterial calcification. | 26652270 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Myelodysplastic syndromes (MDS) are a heterogenous group of clonal hematopoietic stem cell disorders characterized by increased risk of leukemic transformation. | 26657287 |
| Hollings Cancer Center | Stem Cell Exhaustion | A sorafenib-resistance 175 gene signature was characterised by enrichment of progenitor cell features, aggressive tumorous traits and predicted poor survival in two cohorts (n=442 patients with HCC). | 26658144 |
| Specialty Type - cancer, Carcinoma, Transitional Cell | Stem Cell Exhaustion | Gemcitabine and mitomycin induced autophagy regulates cancer stem cell pool in urothelial carcinoma cells. | 26658162 |
| Specialty Type - cancer, Ulcerative Colitis | Stem Cell Exhaustion | It has been suggested that UC are driven by a rare subset of cancer stem cells (CSCs). | 26658162 |
| Graft-vs-Host Disease, Toxic effect, Acute GVH disease | Stem Cell Exhaustion | Methotrexate (MTX) toxicity can hamper the administration of all planned doses in acute graft-versus-host disease (GVHD) prophylaxis following allogeneic hematopoietic stem cell transplantation. | 26658911 |
| Graft-vs-Host Disease, Nephrotic Syndrome, Nuclear non-senile cataract, Chronic graft-versus-host disease | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (HSCT)-related nephrotic syndrome (NS) is a rare event and has been described as a clinical form of chronic graft-versus-host disease (GVHD). | 26659462 |
| Liver diseases | Stem Cell Exhaustion | Several clinical experiments have been reported on the safety of bone marrow-derived stem cells to treat liver disorders. | 26659833 |
| Clostridium difficile infection | Stem Cell Exhaustion | Peri-transplant clostridium difficile infections in patients undergoing allogeneic hematopoietic progenitor cell transplant. | 26661725 |
| Hematologic Neoplasms, Central Diabetes Insipidus | Stem Cell Exhaustion | Patients with hematologic malignancies, especially those who undergo hematopoietic progenitor cell transplants are particularly at risk for developing CDI. | 26661725 |
| Clostridium difficile infection | Stem Cell Exhaustion | One hundred and forty seven consecutive allogeneic hematopoietic progenitor cell transplants were analyzed for peri-transplant Clostridium difficile infections (PT-CDI). | 26661725 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Impact of age on outcomes of allogeneic hematopoietic stem cell transplantation with reduced intensity conditioning in elderly patients with acute myeloid leukemia. | 26663096 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Previous studies have repeatedly reported that increasing age is a significant risk factor for worse outcomes after allogeneic hematopoietic stem cell transplantation (allo-HSCT) among patients with acute myeloid leukemia (AML). | 26663096 |
| Myeloid Leukemia, Chronic, Chromosome Aberrations | Stem Cell Exhaustion | CML = Chronic Myeloid Leukemia, BCR-ABL1 = Break Cluster Region - Abelson gene, TKI = tyrosine kinase inhibitor treatment, ACAs = additional cytogenetic abnormalities, CCyR = complete cytogenetic response, PCyR = partial cytogenetic response, mCyR = minor cytogenetic response, MMR = major molecular response, HSCT = hematopoietic stem cell transplant, HLA = human leukocyte antigens, CP = chronic phase, AP = accelerated phase, BP = blast phase, OS = overall survival, CBA = chromosome banding analysis, +8 = trisomy 8, i(17q) = isochromosome (17q), +Ph = second Philadelphia chromosome, -7 = monosomy 7, -17 = monosomy 17, +17 = trisomy 17, -21 = monosomy 21, +21 = trisomy 21, -Y = loss of Y chromosome, ELN = European LeukemiaNet, IMA600 = Imatinib 600 mg daily, IMA400 = Imatinib 400 mg daily, NILO600 = Nilotinib 600 mg daily, DASA100 = Dasatinib 100mg daily, DASA140 = Dasatinib 140 mg daily. | 26664479 |
| Abnormal vision | Stem Cell Exhaustion | To report bone marrow derived stem cell application in a patient with bilateral visual loss due to accidental ingestion of methanol. | 26665934 |
| Abnormal vision | Stem Cell Exhaustion | Treatment with retrobulbar and intrathecal autologous bone marrow derived stem cell in an adult male patient with bilateral visual loss due to accidental ingestion of methanol was effective. | 26665934 |
| Blindness | Stem Cell Exhaustion | Therapeutic Application of Bone Marrow-Derived Stem Cells in a Patient with Methanol-Induced Blindness. | 26665934 |
| Abnormal vision | Stem Cell Exhaustion | A 22-year-old male patient with bilateral visual loss at discharge after treatment for methanol ingestion was treated with retrobulbar and intrathecal autologus bone marrow derived stem cells in an outpatient setting. | 26665934 |
| Acute myocardial infarction | Stem Cell Exhaustion | Few data are available regarding the relation of left ventricular (LV) mechanical dyssynchrony to remodelling after acute myocardial infarction (MI) and stem cell therapy. | 26666236 |
| Relapsing course, Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | Relapsed or refractory diffuse large B-cell lymphoma (DLBCL) not suitable for high dose chemotherapy with autologous stem cell transplantation (ASCT) has a dismal prognosis and no standard therapy. | 26666433 |
| Aplastic Anemia, Lymphoproliferative Disorders | Stem Cell Exhaustion | Successful Allogeneic Stem Cell Transplantation for Severe Aplastic Anemia after Treatment of Lymphoproliferative Disorder Caused by Rabbit Antithymocyte Globulin. | 26666612 |
| Aplastic Anemia, CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology | Stem Cell Exhaustion | Immunosuppressive therapy (IST) with a combination of antithymocyte globulin (ATG) and cyclosporine (CsA) is an effective therapeutic modality for patients with aplastic anemia (AA) who are not eligible for allogeneic stem cell transplantation (Allo-SCT) from a human leukocyte antigen-identical sibling donor. | 26666612 |
| Malnutrition | Stem Cell Exhaustion | nutritional status before hematopoietic stem cell transplantation (HSCT) affects prognosis: better nourished patients have shorter time to engraftment, while malnutrition is associated with increase of mortality rates, complications, medical costs, poor quality of life and hospitalization stay. | 26667746 |
| Communicable Diseases | Stem Cell Exhaustion | An allogeneic hematopoietic stem cell transplantation (allo-HSCT)-stratified analysis revealed that the effect observed for the IL4Rrs2107356 and IFNgrs2069705 SNPs was stronger in allo-HSCT (IL4Rrs2107356 OR, 5.63; 95% CI, 1.20 to 3.09; IFNgrs2069705 OR, 0.24; 95% CI, 0.10 to 0.59) than in non-HSCT patients, suggesting that the presence of these SNPs renders patients more vulnerable to infection, especially under severe and prolonged immunosuppressive conditions. | 26667837 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Predicted indirectly recognizable HLA epitopes (PIRCHE) computationally predict donor T-cell recognition of mismatched-HLA derived peptides following allogeneic haematopoietic stem-cell transplantation (allo-HSCT), as is evidenced by the correlation between presence of HLA-DPB1-derived PIRCHE and the occurrence of graft-vs.-host disease (GVHD). | 26669207 |
| Acute GVH disease | Stem Cell Exhaustion | A donor-specific epigenetic classifier for acute graft-versus-host disease severity in hematopoietic stem cell transplantation. | 26669438 |
| Venous Thrombosis, Autoimmune cytopenia, Hodgkin Disease, Communicable Diseases | Stem Cell Exhaustion | Successful management of multilineage autoimmune cytopenia complicated with severe infection and deep vein thrombosis in a patient with Hodgkin lymphoma post-autologous hematopoietic stem cell transplantation. | 26670732 |
| Crohn Disease | Stem Cell Exhaustion | Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease: A Randomized Clinical Trial. | 26670970 |
| Crohn Disease | Stem Cell Exhaustion | Case reports and series suggest hematopoietic stem cell transplantation (HSCT) may benefit some patients with Crohn disease. | 26670970 |
| Colorectal Carcinoma, Specialty Type - cancer, Cytogenetic Complete Response | Stem Cell Exhaustion | Lgr5 has recently been identified as a reliable biomarker of cancer stem cells (CSCs) in colorectal cancer (CRC); however, its prognostic value is still controversial. | 26674601 |
| Disease, Inflammation, Hypomyelination | Stem Cell Exhaustion | These findings should help to design novel therapeutic strategies combining immunomodulation and stem/progenitor cell-based therapy for disorders associating hypomyelination with inflammation as observed in PMD. | 26676415 |
| ANOPHTHALMIA AND PULMONARY HYPOPLASIA | Stem Cell Exhaustion | While no cure exists for PMD, experimental cell-based therapy in the dysmyelinated shiverer model suggested that human oligodendrocyte progenitor cells (hOPCs) or human neural precursor cells (hNPCs) are promising candidates to treat myelinopathies. | 26676415 |
| Colorectal Carcinoma | Stem Cell Exhaustion | HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer. | 26678341 |
| Specialty Type - cancer, Malignant tumor of colon, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | In colon cancer, HOXA5 is downregulated, and its re-expression induces loss of the cancer stem cell phenotype, preventing tumor progression and metastasis. | 26678341 |
| Neoplasms, Malignant tumor of colon, Specialty Type - cancer | Stem Cell Exhaustion | Tumor regression by HOXA5 induction can be triggered by retinoids, which represent tangible means to treat colon cancer by eliminating cancer stem cells. | 26678341 |
| Hematopoietic Neoplasms, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Acute myeloid leukemia (AML) is a group of heterogeneous hematopoietic malignancies sustained by leukemic stem cells (LSCs) that can resist treatment. | 26678889 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Correlation of somatic mutations with outcome after FLAMSA-busulfan sequential conditioning and allogeneic stem cell transplantation in patients with myelodysplastic syndromes. | 26680262 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment option for myelodysplastic syndromes (MDS). | 26680262 |
| Weight decreased | Stem Cell Exhaustion | Weight Loss and Decrease of Body Mass Index during Allogeneic Stem Cell Transplantation Are Common Events with Limited Clinical Impact. | 26683031 |
| Type 2 | Stem Cell Exhaustion | Chondrogenic progenitor cells (CPCs) produced high levels of laminin-a1, laminin-a5, and nidogen-2 in their pericellular matrix, and laminin-a1 enhanced collagen type II and reduced collagen type I expression by cultured CPCs. | 26683663 |
| Filamentous fungus, Malignant Neoplasms | Stem Cell Exhaustion | Patients with suspected invasive mould disease were randomised in a 1:1 ratio using an interactive voice-web response system, stratified by geographical region, allogeneic haemopoietic stem cell transplantation, and active malignant disease at baseline, to receive isavuconazonium sulfate 372 mg (prodrug; equivalent to 200 mg isavuconazole; intravenously three times a day on days 1 and 2, then either intravenously or orally once daily) or voriconazole (6 mg/kg intravenously twice daily on day 1, 4 mg/kg intravenously twice daily on day 2, then intravenously 4 mg/kg twice daily or orally 200 mg twice daily from day 3 onwards). | 26684607 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Cyclophosphamide plus intravenous busulfan has not been compared with cyclophosphamide plus total body irradiation (TBI) in adults with advanced refractory acute myeloid leukaemia before allogeneic haemopoietic stem-cell transplantation (HCT). | 26685771 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Post-remission treatment with allogeneic stem cell transplantation in patients aged 60 years and older with acute myeloid leukaemia: a time-dependent analysis. | 26686044 |
| Keratitis, Herpetic, Keratopathy, Keratitis, herpesvirus 3, human | Stem Cell Exhaustion | Patients were excluded who had coexisting potential causes for dendritiform keratopathy, such as prior herpes simplex keratitis, varicella-zoster viral keratitis, the linear form of Thygeson's superficial keratitis, epithelial regeneration line, Acanthamoeba keratitis, mucus plaque keratopathy, medication-related keratopathy, or limbal stem cell deficiency characterized by conjunctivalization of the corneal epithelium. | 26686962 |
| Conjunctival congestion, Corneal Opacity | Stem Cell Exhaustion | The parameters evaluated were the best-corrected visual acuity (BCVA), Schirmer test, tear film breakup time (TBUT), conjunctival congestion, corneal haze, vascularization, conjunctivalization, and limbal stem cell involvement. | 26686968 |
| Corneal Opacity | Stem Cell Exhaustion | No case in the AMT group demonstrated corneal haze, limbal stem cell deficiency, symblepharon, ankyloblepharon, or lid-related complications. | 26686968 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease (GVHD) is the major cause of non-relapse mortality after allogeneic haemopoietic stem-cell transplantation (SCT). | 26687425 |
| Neoplasm Metastasis, Childhood Breast Carcinoma | Stem Cell Exhaustion | Breast cancer stem cells (BCSCs) play essential roles in tumor metastasis and contribute to remarkably negative clinical outcomes. | 26687806 |
| Cessation of life, Neoplasm Metastasis | Stem Cell Exhaustion | The most common causes of death were progression to advanced disease stage, including complications of stem-cell transplantation (17 [4%] patients), secondary malignancies (nine [2%] patients), and cardiovascular causes (nine [2%] patients). | 26688093 |
| Prostate carcinoma | Stem Cell Exhaustion | Characterization of reactive stroma in prostate cancer: involvement of growth factors, metalloproteinase matrix, sexual hormones receptors and prostatic stem cells. | 26689510 |
| Prostate carcinoma, Passive Cutaneous Anaphylaxis, Malignant neoplasm of prostate | Stem Cell Exhaustion | The objectives of the present study were to stablish a relationship of the RStr microenvironment with prostate cancer (Pca) through a morphological and molecular characterization, and to identify a possible relationship between RStr with worse prognosis factors and occurrence of malignant prostatic stem cells. | 26689510 |
| Passive Cutaneous Anaphylaxis | Stem Cell Exhaustion | It can be concluded that RStr may be a predictive marker of Pca progression, since it was associated with increase of growth factors, imbalance of androgen and estrogen receptors and presence of malign prostatic stem cells. | 26689510 |
| Metabolic Syndrome X | Stem Cell Exhaustion | Impact of a lifestyle modification program on the metabolic syndrome and associated risk factors in long-term survivors of stem cell transplantation. | 26691422 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Despite survival improvement with novel agents and use of autologous hematopoietic stem cell transplantation (HSCT), cure of patients with multiple myeloma (MM) remains anecdotal. | 26691426 |
| Disseminated neuroblastoma | Stem Cell Exhaustion | Cord blood may be a feasible alternative stem cell source for auto-SCT in patients with stage 4 neuroblastoma, and outcomes may be improved compared to autologous PBSC or BM transplants. | 26694195 |
| Diabetes | Stem Cell Exhaustion | Acute Effects of Linagliptin on Progenitor Cells, Monocyte Phenotypes, and Soluble Mediators in Type 2 Diabetes. | 26695864 |
| Complications of Diabetes Mellitus | Stem Cell Exhaustion | Circulating cells, including endothelial progenitor cells (EPCs) and monocyte subtypes, are involved in diabetic complications. | 26695864 |
| Chronic Kidney Diseases | Stem Cell Exhaustion | The effects of linagliptin on progenitor cells and monocyte subtypes were similar in patients with or without CKD. | 26695864 |
| Specialty Type - cancer | Stem Cell Exhaustion | Correlation between expressions of stem cell-related molecules (ALDH-1, Notch 1, CD44) and epithelial-mesenchymal transition-related molecules (E-cadherin, S100A4) in cancer cells within VI and RFS was also analyzed. | 26696594 |
| Hypertrophic Cardiomyopathy | Stem Cell Exhaustion | Endothelial progenitor cells as markers of severity in hypertrophic cardiomyopathy. | 26696595 |
| Lymphoma, leukemia | Stem Cell Exhaustion | Consultations were recorded with 10 POs and 66 adolescents, aged 12-20 years, treated for leukemia (72.7%) or lymphoma (21.2%), or who had received hematopoietic stem-cell transplantation for a benign disease (7.6%). | 26697269 |
| Cataract | Stem Cell Exhaustion | Outcome of cataract surgery following simple limbal epithelial transplantation for lime injury-induced limbal stem cell deficiency. | 26698204 |
| Burn, CTCAE | Stem Cell Exhaustion | A 19-year-old woman presented to us after being diagnosed elsewhere with right eye total limbal stem cell deficiency resulting from a lime burn. | 26698204 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | The Stat3/5 Signaling Biosignature in Hematopoietic Stem/Progenitor Cells Predicts Response and Outcome in Myelodysplastic Syndrome Patients Treated with Azacitidine. | 26700206 |
| Specialty Type - cancer | Stem Cell Exhaustion | Analysis of human tissue and human hepatic tumor cells in vitro revealed cells that express LPAR3 (HCC-NTL margin in vivo and SKHep1 in vitro) also express cancer stem cell markers in the absence of hepatocyte markers. | 26701886 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | These data suggest cells that stain positive for both LPAR3 and cancer stem cell markers are distinct from the tumor mass per se, and may mediate tumor invasiveness/expansion via LPA-LPAR3 signaling. | 26701886 |
| Malignant neoplasm of liver | Stem Cell Exhaustion | Expression and function of lysophosphatidic acid receptors (LPARs) 1 and 3 in human hepatic cancer progenitor cells. | 26701886 |
| Glioblastoma Multiforme Pathway, Neoplasms | Stem Cell Exhaustion | These findings suggest that miR-21 is linked to glioma angiogenesis, that miR-21 is unlikely to regulate PTEN, and that miR-21-positive tumor cells do not possess stem cell characteristics. | 26701969 |
| Autoimmune reaction, Acquired aplastic anemia | Stem Cell Exhaustion | Acquired aplastic anemia (aAA) results from the T cell-mediated autoimmune destruction of hematopoietic stem cells. | 26702937 |
| Amyloidosis | Stem Cell Exhaustion | High-dose melphalan and autologous stem cell transplantation for systemic light-chain amyloidosis: a single institution retrospective analysis of 40 cases. | 26703787 |
| Amyloidosis | Stem Cell Exhaustion | We report our retrospective analysis of 40 patients who received high-dose melphalan and autologous stem cell transplantation for systemic immunoglobulin light-chain (AL) amyloidosis. | 26703787 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cell markers have become a major research focus because of their relationship with radiation or chemotherapy resistance in cancer therapy. | 26706028 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cell markers including OCT4 and SOX2 have been found in various solid tumors. | 26706028 |
| Hypoxic-Ischemic Encephalopathy | Stem Cell Exhaustion | Transplantation of placenta-derived mesenchymal stem cells reduces hypoxic-ischemic brain damage in rats by ameliorating the inflammatory response. | 26707403 |
| Development International Birth Date | Stem Cell Exhaustion | The purpose of our research was to explore the immunoregulatory mechanism of placenta-derived mesenchymal stem cells (PD-MSCs) in HIBD treatment. | 26707403 |
| Primary Myelofibrosis | Stem Cell Exhaustion | Cytokine Expression Pattern in Bone Marrow Microenvironment after Allogeneic Stem Cell Transplantation in Primary Myelofibrosis. | 26708839 |
| Primary Myelofibrosis, PMF Regimen | Stem Cell Exhaustion | The only curative therapy for primary myelofibrosis (PMF) is allogeneic stem cell transplantation (ASCT). | 26708839 |
| Acute myocardial infarction | Stem Cell Exhaustion | In animal models, G-CSF based progenitor cell mobilization combined with a DPP4 inhibitor leads to increased homing of bone marrow derived progenitor cells to the injured myocardium via the SDF1/CXCR4 axis resulting in improved ejection fraction and survival after acute myocardial infarction (AMI). | 26709136 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Progenitor cell therapy comprising the use of G-CSF and Sitagliptin after successfully revascularized acute myocardial infarction fails to show a beneficial effect on cardiac function and clinical events after 12 months. | 26709136 |
| Hematologic Neoplasms | Stem Cell Exhaustion | This analysis compared duration of RV shedding as detected by culture and PCR among patients in a high-risk oncology setting (adult patients with haematological malignancy and/or stem cell transplant and all paediatric oncology patients) and determined risk factors for extended shedding. | 26711433 |
| Rheumatoid Arthritis, Degenerative polyarthritis | Stem Cell Exhaustion | Adipose-derived mesenchymal stem cells from infrapatellar fat pad of patients with rheumatoid arthritis and osteoarthritis have comparable immunomodulatory properties. | 26711868 |
| Mycoses | Stem Cell Exhaustion | Incidence and characteristics of invasive fungal diseases in allogeneic hematopoietic stem cell transplant recipients: a retrospective cohort study. | 26715563 |
| Mycoses | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplant (HSCT) recipients experience an increased risk for invasive fungal diseases (IFDs). | 26715563 |
| Malignant neoplasm of stomach, Krukenberg Tumor | Stem Cell Exhaustion | Isolation and comparison of mesenchymal stem cell-like cells derived from human gastric cancer tissues and corresponding ovarian metastases. | 26718033 |
| Neoplasms | Stem Cell Exhaustion | Mesenchymal stem cell (MSC)-like cells have been isolated from various types of tumor. | 26718033 |
| Inflammation, Autoimmune state, Atherosclerosis, Malignant Peripheral Nerve Sheath Tumor | Stem Cell Exhaustion | It is discussed if chronic inflammation in relation to autoimmunity and atherosclerosis might elicit mutations in the hematopoietic stem cell resulting in MPNs, or whether this association actually reflects a long-lasting pre-MPN-diagnosis phase, in which the MPN-disease per se contributes to a chronic inflammatory state and immune deregulation. | 26718091 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Tripartite motif 16 suppresses breast cancer stem cell properties through regulation of Gli-1 degradation via the ubiquitin-proteasome pathway. | 26718507 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells (CSCs) are responsible for cancer progression and patient prognosis. | 26718507 |
| Purpura, Thrombotic Thrombocytopenic | Stem Cell Exhaustion | Baseline CECs and circulating endothelial progenitor cells showed marginal associations with TTP. | 26721701 |
| Specialty Type - cancer, Neoplasms, Vascular Tissue | Stem Cell Exhaustion | Expression of cancer stem cell markers and their correlation with pathogenesis in vascular tumors. | 26722452 |
| Specialty Type - cancer, Neoplasms, Vascular Tissue | Stem Cell Exhaustion | Thus the purpose of this study was to explore whether different expression level of cancer stem cell markers including CD29, CD44, CD133, nestin and ALDH1 in vascular tumor may help to elucidate the possible pathogenesis of vascular tumor. | 26722452 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Previous studies have reported an association of cancer stem cells with the development of tumor in many solid tumors. | 26722452 |
| Specialty Type - cancer, Neoplasms, Vascular Tissue | Stem Cell Exhaustion | Our findings confirmed that the five cancer stem cells markers, including CD29, CD44, CD133, nestin and ALDH1, exhibited different expression levels in vascular tumors and demonstrated that immunohistochemical analysis for cancer stem cells markers may provide useful information for studying the pathogenesis of vascular tumors. | 26722452 |
| Gastrointestinal Stromal Tumors, Neoplasms | Stem Cell Exhaustion | Gastrointestinal stromal tumor is the most common stromal tumor, which is usually considered as originating from Cajal cells in the gastrointestinal tract or mesenchymal stem cells with the mutation of KIT or PDGFRA gene. | 26722567 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation as Adjuvant Treatment in High-Risk Breast Cancer: Data from the European Group for Blood and Marrow Transplantation Registry. | 26723932 |
| Best Case Imputation Technique, Toxic effect, Childhood Breast Carcinoma | Stem Cell Exhaustion | The aim of this retrospective study was to assess toxicity and efficacy of adjuvant high-dose chemotherapy (HDC) and autologous hematopoietic stem cell transplantation (AHSCT) in 583 high-risk breast cancer (BC) patients (>3 positive nodes) who were transplanted between 1995 and 2005 in Europe. | 26723932 |
| Central Diabetes Insipidus | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (HSCT) confers increased risk for CDI because of prolonged hospital stay, immunosuppression, the need to use broad-spectrum antibiotics and a complex interplay of preparative regimen and GvHD-induced gut mucosal damage. | 26726944 |
| Alport Syndrome | Stem Cell Exhaustion | Human Chorionic Stem Cells: Podocyte Differentiation and Potential for the Treatment of Alport Syndrome. | 26728561 |
| Medial collateral ligament, Mantle cell lymphoma | Stem Cell Exhaustion | Chemoimmunotherapy followed by autologous stem cell transplantation (ASCT) is a standard therapy for transplant-eligible patients with newly diagnosed mantle cell lymphoma (MCL). | 26729345 |
| Graft-vs-Host Disease, Lymphoma | Stem Cell Exhaustion | The addition of sirolimus to the graft-versus-host disease prophylaxis regimen in reduced intensity allogeneic stem cell transplantation for lymphoma: a multicentre randomized trial. | 26729448 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | The mTOR inhibitor sirolimus has been used in the prevention and treatment of graft-versus-host disease (GVHD) after allogeneic haematopoietic stem cell transplantation (HSCT). | 26729448 |
| Endometrial Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Progestin treatment decreases CD133+ cancer stem cell populations in endometrial cancer. | 26731726 |
| Endometrial Carcinoma | Stem Cell Exhaustion | CD133 is a marker of endometrial cancer stem cells. | 26731726 |
| Liver carcinoma, Experimental Organism Malignant Hepatocholangiocellular Carcinoma, Malignant neoplasm of liver | Stem Cell Exhaustion | Clinicopathologic Characteristics of Hepatocellular Carcinoma With Reactive Ductule-like Components, a Subset of Liver Cancer Currently Classified as Combined Hepatocellular-Cholangiocarcinoma With Stem-Cell Features, Typical Subtype. | 26735856 |
| Liver carcinoma, Carcinogenic Chlorinated Hydrocarbon, Experimental Organism Malignant Hepatocholangiocellular Carcinoma | Stem Cell Exhaustion | The aim of this study was to elucidate the clinicopathologic characteristics of hepatocellular carcinoma with reactive ductule-like components (HCC-RD), corresponding to combined hepatocellular-cholangiocarcinoma (CHC) with stem cell features, typical subtype. | 26735856 |
| Sarcopenia | Stem Cell Exhaustion | As autophagy also declines in human geriatric satellite cells, our findings reveal autophagy to be a decisive stem-cell-fate regulator, with implications for fostering muscle regeneration in sarcopenia. | 26738589 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We first quantified RBM38 and DND1 mRNA expression in clinical AML patient samples and CD34(+) progenitor cells and mature granulocytes from healthy donors. | 26740055 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We found significantly lower RBM38 and DND1 mRNA levels in AML blasts and CD34(+) progenitor cells as compared to mature neutrophils from healthy donors. | 26740055 |
| Specialty Type - cancer | Stem Cell Exhaustion | Long-Term Follow-Up of Allogeneic Hematopoietic Stem Cell Transplantation for Solid Cancer. | 26740375 |
| Specialty Type - cancer | Stem Cell Exhaustion | We wanted to determine whether allogeneic hematopoietic stem cell transplantation (HSCT) may result in long-term survival in patients with solid cancer. | 26740375 |
| Hemorrhagic cystitis | Stem Cell Exhaustion | Hemorrhagic Cystitis Requiring Bladder Irrigation is Associated with Poor Mortality in Hospitalized Stem Cell Transplant Patients. | 26742970 |
| Hematuria, CTCAE | Stem Cell Exhaustion | To evaluate the overall prognosis of post-stem cell transplant inpatients who required continuous bladder irrigation (CBI) for hematuria. | 26742970 |
| Hemorrhagic cystitis | Stem Cell Exhaustion | We performed a retrospective analysis of adult stem cell transplant recipients who received CBI for de novo hemorrhagic cystitis as inpatients on the bone marrow transplant service at Washington University from 2011-2013. | 26742970 |
| cobalt-factor II C20-methyltransferase activity, Systemic disease, Hemorrhagic cystitis | Stem Cell Exhaustion | Hemorrhagic cystitis requiring CBI is a symptom of severe systemic disease in stem cell transplant patients. | 26742970 |
| Malignant Neoplasms | Stem Cell Exhaustion | The goal of this study was to determine whether single nucleotide polymorphisms (SNPs) in genes involved in gemcitabine metabolism, DNA damage repair, multidrug resistance, and alkylator detoxification influence the clinical outcome of patients with refractory/relapsed lymphoid malignancies receiving high-dose gemcitabine/busulfan/melphalan (Gem/Bu/Mel) with autologous stem cell support. | 26743341 |
| Hyperpyrexia | Stem Cell Exhaustion | Rapid diagnosis of Propionibacterium acnes infection in patient with hyperpyrexia after hematopoietic stem cell transplantation by next-generation sequencing: a case report. | 26743541 |
| Juvenile Myelomonocytic Leukemia, Exanthema, Hyperpyrexia | Stem Cell Exhaustion | After haploidentical hematopoietic stem cell transplantation, a two-year-old boy with juvenile myelomonocytic leukemia presented to a pediatrist in a medical facility with hyperpyrexia and red skin rash which later changed to black skin rash all over his body. | 26743541 |
| Alzheimers Disease | Stem Cell Exhaustion | Human Cortical Neural Stem Cells Expressing Insulin-Like Growth Factor-I: A Novel Cellular Therapy for Alzheimer's Disease. | 26744412 |
| Amyotrophic Lateral Sclerosis, Inflammation, Pathology | Stem Cell Exhaustion | In amyotrophic lateral sclerosis, we have shown that transplanted spinal neural stem cells (NSCs) integrate into the spinal cord, form synapses with the host, improve inflammation, and reduce disease-associated pathologies. | 26744412 |
| Microvascular Angina, Erectile dysfunction, Diabetes Mellitus, Hypertension, CTCAE | Stem Cell Exhaustion | Stem cell therapy is thought to improve wound healing and promote vasculogenesis and has also been investigated as a treatment for patients with erectile dysfunction (ED), which is usually caused by a microvascular disease such as diabetes mellitus or hypertension. | 26745574 |
| Erectile dysfunction | Stem Cell Exhaustion | Determining the Feasibility of Managing Erectile Dysfunction in Humans With Placental-Derived Stem Cells. | 26745574 |
| leukemia | Stem Cell Exhaustion | Naive Donor NK Cell Repertoires Associated with Less Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation. | 26746188 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | The impact of advances in supportive care and hematopoietic stem cell transplantation (HSCT) practices on the outcomes of patients who develop grade III or IV acute graft-versus-host disease (GVHD) is unknown. | 26748160 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | Successful reduced-intensity stem cell transplantation for GATA2 deficiency before progression of advanced MDS. | 26748574 |
| Hematologic Neoplasms, Vancomycin-Resistant Enterococci, Colonization | Stem Cell Exhaustion | OBJECTIVE To study the effect of discontinuation of systematic surveillance for vancomycin-resistant Enterococcus (VRE) and contact isolation of colonized patients on the incidence of VRE bacteremia SETTING A hematology-oncology unit with high prevalence of VRE colonization characterized by predominantly sporadic molecular epidemiology PARTICIPANTS Inpatients with hematologic malignancies and recipients of hematopoietic stem cell transplantation METHODS The incidence of VRE bacteremia was measured prospectively during 2 different 3-year time periods; the first during active VRE surveillance and contact precautions and the second after discontinuation of these policies. | 26750087 |
| Hematologic Neoplasms, Vancomycin-Resistant Enterococci, Colonization | Stem Cell Exhaustion | CONCLUSION Active surveillance and contact precautions for VRE colonization did not appear to prevent VRE bacteremia in patients with hematologic malignancies and recipients of hematopoietic stem cell transplantation with high prevalence of VRE characterized by predominantly sporadic molecular epidemiology. | 26750087 |
| Neoplasms | Stem Cell Exhaustion | Spalt-like transcription factor 4 (SALL4) is a transcription factor which is able to regulate development and embryonic stem cell pluripotency, and it is also involved in some tumor progression. | 26750614 |
| Thalassemia | Stem Cell Exhaustion | Hemopoietic stem cell transplantation in thalassemia: a report from the European Society for Blood and Bone Marrow Transplantation Hemoglobinopathy Registry, 2000-2010. | 26752139 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Durable responses to ibrutinib in patients with relapsed CLL after allogeneic stem cell transplantation. | 26752141 |
| Cessation of life | Stem Cell Exhaustion | Analysis of non-relapse mortality and causes of death over 15 years following allogeneic hematopoietic stem cell transplantation. | 26752142 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has curative potential against hematological malignancies. | 26752142 |
| Alzheimers Disease | Stem Cell Exhaustion | Distribution of human umbilical cord blood-derived mesenchymal stem cells in the Alzheimer's disease transgenic mouse after a single intravenous injection. | 26752148 |
| Alzheimers Disease | Stem Cell Exhaustion | The aim of this study was to track the migration of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) administered through a single intravenous injection and to observe the consequential therapeutic effects in a transgenic Alzheimer's disease mouse model. | 26752148 |
| Inflammation | Stem Cell Exhaustion | Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation. | 26752157 |
| Graft-vs-Host Disease, Leukemia, Myelomonocytic, Chronic | Stem Cell Exhaustion | Impacts of graft-versus-host disease on outcomes after allogeneic hematopoietic stem cell transplantation for chronic myelomonocytic leukemia: A nationwide retrospective study. | 26754557 |
| Leukemia, Myelomonocytic, Chronic | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a therapeutic option that may lead to improved outcomes in patients with chronic myelomonocytic leukemia (CMML). | 26754557 |
| Glioblastoma Multiforme Pathway, Glioma, Neoplasms, Malignant Glioma | Stem Cell Exhaustion | Immunohistochemistry and flow cytometry analysis of 12 tumor samples obtained from patients with high grade gliomas revealed that a considerable population (2-19%) of cells in all malignant gliomas expressed IL-17RA, with remarkable co-expression of the glioma stem cell (GSC) markers CD133, Nestin, and Sox2. | 26755664 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Preferential expression of functional IL-17R in glioma stem cells: potential role in self-renewal. | 26755664 |
| Malignant neoplasm of larynx, Specialty Type - cancer | Stem Cell Exhaustion | The soluble fraction of the CD44 protein (solCD44) may constitute a valuable biological marker of Cancer Stem Cells (CSCs), useful for screening/early detection of laryngeal cancer, and for the prognosis. | 26756618 |
| Diabetes, leukemia | Stem Cell Exhaustion | Survivors of childhood leukaemia treated with haematopoietic stem cell transplantation and total body irradiation should undergo screening for diabetes by oral glucose tolerance tests. | 26757409 |
| Diabetes, Specialty Type - cancer, Impaired T cell function | Stem Cell Exhaustion | Childhood cancer survivors treated with haematopoietic stem cell transplantation (HSCT) and total body irradiation are at an increased risk of developing diabetes early in life due to insulin resistance and b-cell dysfunction, but the optimal screening method is unknown. | 26757409 |
| Anemia, Sickle Cell | Stem Cell Exhaustion | Improved Splenic Function After Hematopoietic Stem Cell Transplant for Sickle Cell Disease. | 26757445 |
| Renal carnitine transport defect | Stem Cell Exhaustion | Hematopoietic stem cell transplant (HSCT) is a proven cure for SCD; however, its long-term effect on splenic function is not well characterized. | 26757445 |
| Malignant Glioma | Stem Cell Exhaustion | Prognostic significance of stem cell marker CD133 determined by promoter methylation but not by immunohistochemical expression in malignant gliomas. | 26757925 |
| Neoplasms | Stem Cell Exhaustion | CD133 has played a pivotal role in the identification and isolation of brain tumor stem cells. | 26757925 |
| Myeloma cell | Stem Cell Exhaustion | Fractionated stem cell infusions for patients with plasma cell myeloma undergoing autologous hematopoietic cell transplantation. | 26758672 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The correlation of TIGIT expression to clinical outcomes, including rate of complete remission and relapse post-allogeneic stem cell transplantation (alloSCT) in AML patients, was analyzed. | 26763253 |
| Myeloid neoplasm | Stem Cell Exhaustion | Loss-of-function of ten-eleven translocation-2 (TET2) is a common event in myeloid malignancies, and plays pleiotropic roles, including augmenting stem cell self-renewal and skewing hematopoietic cells to the myeloid lineage. | 26763362 |
| adult nasal type extranodal NK/T-cell lymphoma | Stem Cell Exhaustion | Intraocular Relapse with Hypopyon and Retinal Infiltrates after Chemotherapy and Peripheral Blood Stem Cell Transplantation for Extranodal NK/T-Cell Lymphoma. | 26763364 |
| Lymphoma, Intraocular Route of Drug Administration | Stem Cell Exhaustion | In conclusion, we report a case of NK/T-cell lymphoma relapse with intraocular lesions, after combined chemotherapy and hematopoietic stem cell transplantation. | 26763364 |
| Autoimmune Diseases, Acquired aplastic anemia | Stem Cell Exhaustion | Memory Stem T Cells in Autoimmune Disease: High Frequency of Circulating CD8+ Memory Stem Cells in Acquired Aplastic Anemia. | 26764034 |
| T-Cell Large Granular Lymphocyte, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Four patients with associated myelodysplastic syndrome and two who had received haemopoietic stem cell transplantation had either no response or were not evaluable, meaning 14 (74% [49-91]) of the 19 patients with classic T-LGL responded. | 26765645 |
| Hematologic Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | In order to further explore the relationship between CD34(+)cell dose and total nucleated cell dose on reduced-intensity transplant outcomes, we analyzed the effect of donor graft dose and composition on outcomes of 705 patients with hematologic malignancies who underwent reduced-intensity peripheral blood stem cell transplantation at the Dana Farber Cancer Institute from 2000 to 2010. | 26768686 |
| HLA Mismatch, Acute GVH disease | Stem Cell Exhaustion | With regard to clinical implications, patient mismatched HLA-C*14:02 proved to be a potent risk factor for severe acute graft-versus-host disease and mortality, and should be considered a non-permissive HLA-C mismatch in donor selection for unrelated donor hematopoietic stem cell transplantation. | 26768690 |
| TAF1 wt Allele, X-linked inheritance | Stem Cell Exhaustion | Decreased N-TAF1 expression in X-linked dystonia-parkinsonism patient-specific neural stem cells. | 26769797 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | TP53 mutation in patients with high-risk acute myeloid leukaemia treated with allogeneic haematopoietic stem cell transplantation. | 26771088 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Here, we studied the impact of TP53 mutations on the outcome of AML patients with adverse cytogenetic risk treated with allogeneic haematopoietic stem cell transplantation (HSCT). | 26771088 |
| histiocytic | Stem Cell Exhaustion | Based on DC induction from hematopoietic stem cells, myeloid progenitors, and monocytes, and occasional expressions of histocyte-related antigens (HRAs) in M5, we presume some M5 cases share histiocytic phenotypes originally. | 26771450 |
| Neoplasms | Stem Cell Exhaustion | Telomerase activity controls telomere length, and this plays an important role in stem cells, aging and tumors. | 26771767 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | These results suggest that LC3 suppresses TNBC in mature tumor cells and cancer stem cells (CSCs). | 26772398 |
| Neoplasms, Fibroepithelial | Stem Cell Exhaustion | The stem cell renewal and DNA damage response pathways are frequently altered in fibroepithelial tumors of breast in Indian patients. | 26774289 |
| Multiple Myeloma | Stem Cell Exhaustion | Phagocyte function decreases after high-dose treatment with melphalan and autologous stem cell transplantation in patients with multiple myeloma. | 26774385 |
| Multiple Myeloma | Stem Cell Exhaustion | High-dose melphalan with autologous hematopoietic stem cell transplantation (ASCT) is the standard of care for younger patients with newly diagnosed multiple myeloma and is aimed at achieving as deep and complete a response as possible after various combinations of induction therapy. | 26774385 |
| Cerebrovascular accident | Stem Cell Exhaustion | Mobilization of Circulating Endothelial Progenitor Cells by dl-3-n-Butylphthalide in Acute Ischemic Stroke Patients. | 26775268 |
| Ischemic stroke | Stem Cell Exhaustion | The research aim was to investigate the effects of dl-3-n-butylphthalide (NBP) on the level of circulating endothelial progenitor cells (EPCs) and clinical outcome in patients with acute ischemic stroke (AIS). | 26775268 |
| Glioblastoma Multiforme Pathway, Neoplasms | Stem Cell Exhaustion | Senescence from glioma stem cell differentiation promotes tumor growth. | 26775840 |
| Glioblastoma Multiforme Pathway, Adult Glioblastoma, Neoplasms | Stem Cell Exhaustion | Glioblastoma (GBM) is a lethal brain tumor composed of heterogeneous cellular populations including glioma stem cells (GSCs) and differentiated non-stem glioma cells (NSGCs). | 26775840 |
| Specialty Type - cancer, Ulcerative Colitis | Stem Cell Exhaustion | Sulfasalazine reduces the risk of ulcerative colitis (UC)-related cancer through its anti-inflammatory effect and induction of oxidative stress in cancer cells by inhibiting the glutamate-cystine transporter, which is closely associated with the cancer stem cell surface marker CD44v9. | 26775891 |
| Specialty Type - cancer, Ulcerative Colitis | Stem Cell Exhaustion | Sulfasalazine, a therapeutic agent for ulcerative colitis, inhibits the growth of CD44v9(+) cancer stem cells in ulcerative colitis-related cancer. | 26775891 |
| Complications of Diabetes Mellitus | Stem Cell Exhaustion | Adipose-derived stem cells (ASCs) represent an important source of cell therapy to treat diabetic complications. | 26780864 |
| Malignant neoplasm of lung, Specialty Type - cancer | Stem Cell Exhaustion | SOX2 signaling is important in maintaining the stem cell-like phenotype of cancer cells and contributes to the pathogenesis of lung cancer. | 26780934 |
| Decreased platelet count | Stem Cell Exhaustion | Bacterial Pneumonia-induced Persistent Remission of Severe Immune Thrombocytopenia after Allogeneic Hematopoietic Stem Cell Transplantation. | 26781020 |
| Allogeneic Hematopoietic Stem Cell Transplantation, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | A 53-year-old woman with chronic myeloid leukemia received allogeneic hematopoietic stem cell transplantation. | 26781020 |
| Limbal stem cell deficiency | Stem Cell Exhaustion | This is a case report of a 50-year-old patient presenting with unilateral limbal stem-cell deficiency who was referred for autologous limbal stem-cell transplant. | 26783982 |
| Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8, diabetic | Stem Cell Exhaustion | We reasoned that coupling hematopoietic stem cells (HSCs) transplantation with ex vivo transduction of syngeneic HSCs with lentiviral vectors to express proinsulin II could prevent T1D in nonobese diabetic (NOD) mice. | 26784909 |
| Lymphoma, Follicular | Stem Cell Exhaustion | The role of autologous stem cell transplantation (ASCT) in patients with relapsed follicular lymphoma (FL) remains controversial because of a lack of proven overall survival (OS) benefit versus nontransplant strategies. | 26785331 |
| Prostate carcinoma | Stem Cell Exhaustion | The role of mesenchymal stem cells in promoting the transformation of androgen-dependent human prostate cancer cells into androgen-independent manner. | 26787499 |
| Prostate carcinoma, Passive Cutaneous Anaphylaxis | Stem Cell Exhaustion | Mesenchymal stem cells (MSCs) play an important role in the development of human prostate cancer (PCa). | 26787499 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | In acute myeloid leukemia (AML), alloreactive natural killer (NK) cells are crucial mediators of immune responses after haploidentical stem cell transplantation. | 26787753 |
| Diabetes | Stem Cell Exhaustion | In recent years, stem cell transplant has led to treatment of various diseases including diabetes. | 26788941 |
| Transitional Meningioma, diabetic | Stem Cell Exhaustion | We sought to report a type 1 diabetic patient with a brain mass, diagnosed as transitional meningioma, after a fetal hematopoietic stem cell transplant. | 26788941 |
| Diabetes Mellitus, Insulin-Dependent, Hemopoietic stem cell transplant, Nausea, Headache, Have Been Vomiting, Visual disturbance | Stem Cell Exhaustion | A 57-year-old woman with type 1 diabetes who previously had undergone a fetal hematopoietic stem cell transplant, attended the clinic with a history of progressive bifrontal headaches accompanied by nausea, vomiting, and visual disturbances over the previous 8 months. | 26788941 |
| Transitional Meningioma | Stem Cell Exhaustion | To our knowledge, this is the first report of transitional meningioma as a result of stem cell transplant. | 26788941 |
| Diabetes Mellitus, Insulin-Dependent | Stem Cell Exhaustion | Despite all unanswered questions about the safety of stem cell transplant, this novel therapy provides hope for patients with type 1 diabetes. | 26788941 |
| Transitional Meningioma | Stem Cell Exhaustion | The results indicated transitional meningioma with the origin of transplanted fetal hematopoietic stem cells. | 26788941 |
| Neoplasms | Stem Cell Exhaustion | Our data indicates that ESRD/ACRD is a novel disease and the inflammatory microenvironment altered plasticity, and stem cell characteristics of epithelial cells may be associated with the high risk of tumor development. | 26790439 |
| Acute myocardial infarction | Stem Cell Exhaustion | Stem cell mobilisation by granulocyte-colony stimulating factor in patients with acute myocardial infarction. | 26790705 |
| Infarction, Acute myocardial infarction, Coronary Restenosis | Stem Cell Exhaustion | In the REVIVAL-2 study we found that stem cell mobilisation by G-CSF does not influence infarct size, left ventricular function and coronary restenosis in patients with acute myocardial infarction (MI) that underwent successful percutaneous coronary intervention. | 26790705 |
| Paralysed, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | One patient suffered from transient paralysis following stem cell transplant for treatment of myelodysplastic syndrome. | 26791929 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | Reactivation of polyomavirus in the genitourinary tract is significantly associated with severe GvHD and oral mucositis following allogeneic stem cell transplantation. | 26792012 |
| Viruria, Hemorrhagic cystitis | Stem Cell Exhaustion | Hemorrhagic cystitis and symptomatic viruria caused by these viruses are a major cause of morbidity in patients undergoing allogeneic stem cell transplantation. | 26792012 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | We investigated the expression of the progenitor/stem cell markers GD3 ganglioside and NG2 proteoglycan in GBM, peritumor tissue (brain adjacent to tumor, BAT) and cancer stem-like cells (CSCs) isolated from GBM (GCSCs) and BAT (PCSCs). | 26792897 |
| Neoplasms | Stem Cell Exhaustion | Moreover, only transduced cultures originating from cultures bearing stem cells induce tumors in nude mice. | 26795563 |
| Neoplasms | Stem Cell Exhaustion | Importantly, high sHLA-GEV levels before NACT were related to disease progression and the detection of stem cell-like circulating tumor cells, but high sHLA-Gfree levels indicated an improved clinical outcome. | 26796737 |
| Malignant Neoplasms | Stem Cell Exhaustion | The non-classical human leukocyte antigen G (HLA-G) molecule and its soluble forms exert multiple immune suppressive regulatory functions in malignancy and in stem cells contributing to immune escape mechanisms. | 26796737 |
| Aplastic Anemia | Stem Cell Exhaustion | Bone marrow (BM) is the preferred graft source for hematopoietic stem cell transplantation (HSCT) in severe aplastic anemia (SAA) compared with mobilized peripheral blood stem cells (PBSCs). | 26797402 |
| Aplastic Anemia | Stem Cell Exhaustion | Comparing Outcomes with Bone Marrow or Peripheral Blood Stem Cells as Graft Source for Matched Sibling Transplants in Severe Aplastic Anemia across Different Economic Regions. | 26797402 |
| Multiple Pregnancy | Stem Cell Exhaustion | Notch signalling regulates stem cell development and survival and is deregulated in multiple malignancies. | 26798966 |
| Specialty Type - cancer, Medullary carcinoma of thyroid | Stem Cell Exhaustion | Expression of the potential cancer stem cell markers CD133 and CD44 in medullary thyroid carcinoma: A ten-year follow-up and prognostic analysis. | 26799258 |
| Specialty Type - cancer, NTRK1 wt Allele, Medullary carcinoma of thyroid | Stem Cell Exhaustion | To investigate the expression profiles of cancer stem cells (CSCs) markers CD133 and CD44 in a cohort of medullary thyroid carcinoma (MTC) patients, and their prognostic values during 10-year follow-up. | 26799258 |
| Infection | Stem Cell Exhaustion | Allogeneic stem cell transplantation is potentially curative, but associated with post-transplantation complications, including cytomegalovirus (CMV) infections. | 26800118 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | This study confirms the poor prognosis of de novo CD5+ DLBCL in a large multi-center cohort despite initial rituximab-containing chemotherapy and suggests that stem cell transplantation fails to salvage the majority of these patients. | 26800311 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | A comparison of tacrolimus and cyclosporine combined with methotrexate for graft-versus-host disease prophylaxis, stratified by stem cell source: a retrospective nationwide survey. | 26800676 |
| leukemia | Stem Cell Exhaustion | Data were obtained from the Transplant Registry Unified Management Program of the Japan Society for Hematopoietic Cell Transplantation for >= 16-year-old leukemia patients who received CsA/MTX or TAC/MTX after bone marrow transplantation and peripheral blood stem cell transplantation from serological HLA-matched related donors (MRD), HLA 8/8 allele-matched, or one allele-mismatched unrelated bone marrow (UBM), or 0-2 antigen-mismatched unrelated cord blood (UCB) transplantation between January 2005 and December 2009. | 26800676 |
| Thalassemia | Stem Cell Exhaustion | Hematopoietic peripheral circulating blood stem cells as an independent marker of good transfusion management in patients with b-thalassemia: results from a preliminary study. | 26801519 |
| Thalassemia | Stem Cell Exhaustion | We investigated the levels of peripheral circulating CD34+ stem cells as an independent marker of appropriate hematopoietic balance in patients with thalassemia. | 26801519 |
| Hypothyroidism | Stem Cell Exhaustion | At multivariate analysis, peripheral circulating CD34+ stem cells did not correlate with age, sex, smoking habit, number of RBCs units transfused, Hb levels, iron chelation therapy, history of splenectomy, and hypothyroidism. | 26801519 |
| Thalassemia | Stem Cell Exhaustion | Circulating peripheral CD34 + stem cells are increased in b-thalassemia, in particular in nontransfused patients, compared to healthy controls. | 26801519 |
| Multiple Myeloma | Stem Cell Exhaustion | The combination of melphalan, prednisone, and thalidomide (MPT) is considered standard therapy for newly diagnosed patients with multiple myeloma who are ineligible for stem cell transplantation. | 26802176 |
| Chief complaint (finding) | Stem Cell Exhaustion | We analyzed, in a prospective monocentric study, three different endothelial biomarkers, endothelial microparticles (EMPs), endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) in 132 older patients who underwent a full evaluation of a memory complaint. | 26803509 |
| Respiratory Distress Syndrome, Newborn | Stem Cell Exhaustion | Epidemiology of Acute Respiratory Distress Syndrome Following Hematopoietic Stem Cell Transplantation. | 26807683 |
| Pulmonary Complication | Stem Cell Exhaustion | Pulmonary complications are common following hematopoietic stem cell transplantation. | 26807683 |
| Respiratory Distress Syndrome, Newborn | Stem Cell Exhaustion | Patients were screened for acute respiratory distress syndrome development within 1 year of hematopoietic stem cell transplantation. | 26807683 |
| Respiratory Distress Syndrome, Newborn | Stem Cell Exhaustion | In total, 133 cases of acute respiratory distress syndrome developed in 2,635 patients undergoing hematopoietic stem cell transplantation (5.0%). | 26807683 |
| Respiratory Distress Syndrome, Newborn | Stem Cell Exhaustion | Acute respiratory distress syndrome developed in 75 patients (15.6%) undergoing allogeneic hematopoietic stem cell transplantation and 58 patients (2.7%) undergoing autologous hematopoietic stem cell transplantation. | 26807683 |
| Respiratory Distress Syndrome, Newborn | Stem Cell Exhaustion | Median time to acute respiratory distress syndrome development was 55.4 days (interquartile range, 15.1-139 d) in allogeneic hematopoietic stem cell transplantation and 14.2 days (interquartile range, 10.5-124 d) in autologous hematopoietic stem cell transplantation. | 26807683 |
| Respiratory Distress Syndrome, Newborn | Stem Cell Exhaustion | At 12 months following hematopoietic stem cell transplantation, 89 patients (66.9%) who developed acute respiratory distress syndrome had died. | 26807683 |
| Respiratory Distress Syndrome, Newborn | Stem Cell Exhaustion | Acute respiratory distress syndrome is a frequent complication following hematopoietic stem cell transplantation, dramatically influencing patient-important outcomes. | 26807683 |
| Respiratory Distress Syndrome, Newborn, Hepatopulmonary Syndrome | Stem Cell Exhaustion | Most cases of acute respiratory distress syndrome following hematopoietic stem cell transplantation do not meet criteria for a more specific post-transplantation pulmonary syndrome. | 26807683 |
| Dry Eye Syndromes | Stem Cell Exhaustion | Dry Eye Disease Is Already Present in Hematological Patients Before Hematopoietic Stem Cell Transplantation. | 26807906 |
| Lymphoproliferative Disorders | Stem Cell Exhaustion | Tear film break-up time was found to be the only parameter statistically worse in the chronic lymphoproliferative disorder group compared with the stem cell malignancy group. | 26807906 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Although allogeneic hematopoietic stem cell transplantation from an HLA-matched sibling donor (MSD) is a potentially curative post-remission treatment for adults with acute myeloid leukemia (AML) in their first CR, transplant-related morbidity and mortality remains a major drawback. | 26808566 |
| Ambiguity | Stem Cell Exhaustion | We retrospectively compared the outcomes of patients who underwent autologous peripheral blood stem cell transplantation (auto-PBSCT; n=375) with those who underwent allogeneic bone marrow transplantation (allo-BMT; n=521) and allo-PBSCT (n=380) from MSDs for adults with AML/CR1, in which propensity score models were used to adjust selection biases among patients, primary physicians and institutions to overcome ambiguity in the patients' background information. | 26808566 |
| Fibrosis Assessment, Dry Eye Syndromes | Stem Cell Exhaustion | After allogeneic hematopoietic stem cell transplantation (allo-SCT), ocular GvHD is a common complication, typical symptoms being dry eye syndrome with features of fibrosis. | 26808567 |
| Prediabetes syndrome | Stem Cell Exhaustion | Mechanisms of mesenchymal stem cell correction of the impaired biomechanical properties of diabetic skin: The role of miR-29a. | 26808714 |
| diabetic | Stem Cell Exhaustion | We further hypothesize that treatment with mesenchymal stem cells (MSCs) may improve diabetic wound healing by correction of the dysregulated miR-29a expression. | 26808714 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Inhibition of Fatty Acid Synthase Decreases Expression of Stemness Markers in Glioma Stem Cells. | 26808816 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | However, little is known about the significance of cellular lipid metabolism in the regulation of biological activity of glioma stem cells (GSCs). | 26808816 |
| Ki-1+ Anaplastic Large Cell Lymphoma, Anaplastic large B-cell lymphoma | Stem Cell Exhaustion | AE: adverse event; ALCL: anaplastic large cell lymphoma; ALK: anaplastic lymphoma kinase; ASCT: autologous stem cell transplant; BEAM: BCNU/carmustine, etoposide, ara-C, and melphalan; BV: brentuximab vedotin; CHEOP: cyclophosphamide, daunorubicin, vincristine, prednisone, etoposide; CHOP: cyclophosphamide, doxorubicin, vincristine, prednisone; CR:complete response; G3+: grade 3 or higher; MTD: maximum tolerated dose; ORR: overall response rate; OS: overall survival; PFS: progression-free survival. | 26809026 |
| Infection | Stem Cell Exhaustion | Infections with human b-herpesviruses are common worldwide and are still frequent in patients after hematopoietic stem cell transplantation. | 26809130 |
| Coinfection, Cytomegalovirus Infections | Stem Cell Exhaustion | The co-infection with these b-herpesviruses could predispose patients after hematopoietic stem cell transplantation to a longer and more severe CMV infection. | 26809130 |
| Nocardia Infections | Stem Cell Exhaustion | Nocardiosis following hematopoietic stem cell transplantation. | 26809666 |
| Hematologic Neoplasms, Nocardia Infections | Stem Cell Exhaustion | Patients with hematologic malignancies undergoing hematopoietic stem cell transplantation (HSCT) are at risk for nocardiosis, and further data in regard to characteristics of disease in this population are warranted. | 26809666 |
| Hemorrhagic cystitis | Stem Cell Exhaustion | Studies of human polyomaviruses, with HPyV7, BKPyV, and JCPyV present in urine of allogeneic hematopoietic stem cell transplanted patients with or without hemorrhagic cystitis. | 26809742 |
| CLTC gene, Hemorrhagic cystitis, Nephritis, Leukoencephalopathy, Immunocompromised Host | Stem Cell Exhaustion | BK polyomavirus (BKPyV) can cause hemorrhagic cystitis (HC) in allogeneic hematopoietic stem cell transplant (allo-HSCT) patients and polyomavirus-associated nephritis in renal transplant patients, while JC polyomavirus (JCPyV) can generate progressive multifocal leukoencephalopathy in immunocompromised individuals. | 26809742 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | Primary central nervous system lymphoma in daily practice and the role of autologous stem cell transplantation in relapsed disease: A retrospective multicenter study. | 26810141 |
| Malignant Neoplasms | Stem Cell Exhaustion | Allogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host Disease. | 26811520 |
| Cessation of life, Malignant Neoplasms | Stem Cell Exhaustion | Progressive malignancy is the leading cause of death after allogeneic hematopoietic stem-cell transplantation (alloHSCT). | 26811520 |
| Central neuroblastoma | Stem Cell Exhaustion | Importantly, we demonstrate that catechol-derived oxidants can be quantified in human neuroblastoma cells and midbrain dopamine neurons derived from induced pluripotent stem cells, providing a novel model to study the downstream actions of o-quinones. | 26813311 |
| Specialty Type - cancer | Stem Cell Exhaustion | We showed that the EMT program induced by PRMT1 endowed the human mammary epithelial cells with cancer stem cell properties. | 26813495 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | CD45RA, a specific marker for leukaemia stem cell sub-populations in acute myeloid leukaemia. | 26814163 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Chemotherapy resistant leukaemic stem cells (LSC) are thought to be responsible for relapses after therapy in acute myeloid leukaemia (AML). | 26814163 |
| Kernicterus | Stem Cell Exhaustion | We have investigated the effectiveness of human adiposity-derived stem cells as a therapeutic paradigm for perinatal neuronal repair in a kernicterus animal model. | 26818600 |
| Neurologic Deficits, Brain Injuries | Stem Cell Exhaustion | This study provides important information for the development of therapeutic strategies using human adiposity-derived stem cells in prenatal brain damage to reduce potential sensori motor deficit. | 26818600 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The precise phenotype and biology of acute myeloid leukemia stem cells remain controversial, in part because the "gold standard" immunodeficient mouse engraftment assay fails in a significant fraction of patients and identifies multiple cell-types in others. | 26819054 |
| leukemia | Stem Cell Exhaustion | The CD34(+)CD38(-) leukemia cells in 47 of the 80 patients displayed intermediate aldehyde dehydrogenase expression, while normal CD34(+)CD38(-) hematopoietic stem cells expressed high levels of aldehyde dehydrogenase. | 26819054 |
| leukemia | Stem Cell Exhaustion | The strong clinical correlations suggest that the most immature phenotype detectable in the leukemia might serve as a biomarker for "clinically-relevant" leukemia stem cells. | 26819054 |
| Vascular Hemostatic Disorders, Anemia, Infection, Blood Platelet Disorders, Blood coagulation | Stem Cell Exhaustion | This progress highlights the potential of focused basic research programs such as this EHA Roadmap.The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. | 26819058 |
| Disease, malignant disease | Stem Cell Exhaustion | These sections span 60 smaller groups of diseases or disorders.The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients. | 26819058 |
| leukemia | Stem Cell Exhaustion | Donor leukocyte infusion (DLI) is used to treat relapsed leukemia after allogeneic hematopoietic stem cell transplant (HCT). | 26820493 |
| Specialty Type - cancer | Stem Cell Exhaustion | POU5F1 is a key regulator of self-renewal and differentiation in embryonic stem cells and may be associated with initiation, promotion, and progression in cancer. | 26824036 |
| Cell Death, Myocardial Ischemia | Stem Cell Exhaustion | In conventional stem cell transplantation therapies for ischemic limb diseases, stem cells are generally transplanted into the ischemic region (IR), and most of the transplanted cells undergo hypoxia-mediated cell death. | 26824782 |
| Ischemia | Stem Cell Exhaustion | In this study, we investigated whether the therapeutic efficacy can be improved and the cell dosage can be reduced in the therapy for limb ischemia simply by modifying the stem cell injection site to a site where cell engraftment is improved and blood vessel sprouting is efficiently stimulated. | 26824782 |
| Myocardial Ischemia | Stem Cell Exhaustion | Therefore, modification of the stem cell transplantation site would improve the current stem cell therapies for ischemic limb diseases in terms of cell dosage reduction and therapeutic efficacy enhancement. | 26824782 |
| Cell Death | Stem Cell Exhaustion | Due to massive cell death, the therapeutic efficacy is reduced and a high dose of stem cells is necessitated for the therapies. | 26824782 |
| Cessation of life | Stem Cell Exhaustion | Human mesenchymal stem cells (hMSCs) cultured under hypoxic condition, which simulates cells transplanted to IR, underwent extensive cell death in vitro. | 26824782 |
| Hepatic Veno-Occlusive Disease, Venoocclusive disease | Stem Cell Exhaustion | Hepatic veno-occlusive disease (VOD), also called sinusoidal obstruction syndrome (SOS), is a potentially life-threatening complication of hematopoietic stem cell transplantation (HSCT). | 26825712 |
| Neoplasms | Stem Cell Exhaustion | Cytokeratin-positive interstitial reticulum cell (CIRC) tumor is a very rare accessory cell neoplasm of lymphoid organs derived from fibroblastic reticulum cells, which originate from mesenchymal stem cells. | 26826404 |
| Impaired T cell function, Thrombosis | Stem Cell Exhaustion | Downregulation of let-7e-5p contributes to endothelial progenitor cell dysfunction in deep vein thrombosis via targeting FASLG. | 26826505 |
| Deep Vein Thrombosis, Thrombosis | Stem Cell Exhaustion | This study aimed to evaluate the role of let-7e-5p in endothelial progenitor cells (EPCs) function and explore its therapeutic potential for deep vein thrombosis (DVT). | 26826505 |
| BCR gene | Stem Cell Exhaustion | Allogeneic stem cell transplantations are indicated in high-risk subgroups of infant ALL (age below 6 months, high hyperleucocytosis >300.10(9)/L, MLL-rearrangement, initial poor prednisone response). | 26826739 |
| Multiple Myeloma | Stem Cell Exhaustion | This phase Ib clinical trial evaluated whether pretargeting of CD20(+) clonogenic myeloma precursor cells (CMPCs) with anti-CD3 x anti-CD20 bispecific antibody-armed T cells (BATs) before autologous stem cell transplantation (SCT) in patients with standard-risk and high-risk multiple myeloma would induce antimyeloma immunity that could be detected and boosted after SCT. | 26827660 |
| leukemia, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | A Study of Human Leukocyte Antigen Mismatched Cellular Therapy (Stem Cell Microtransplantation) in High-Risk Myelodysplastic Syndrome or Transformed Acute Myelogenous Leukemia. | 26838271 |
| Toxic effect, PAFAH1B1 wt Allele | Stem Cell Exhaustion | We designed a combination of human leukocyte antigen (HLA)-mismatched hematopoietic stem cell microtransplantation (MST) with chemotherapy for patients with MDS and tAML and evaluated its effects and toxicity. | 26838271 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | It aims to support hematopoietic recovery and perform graft-versus-leukemia (GVL) effects but differs from traditional allogeneic stem cell transplantation because the rate of donor cell chimerism is low and there is and no graft-versus-host disease (GVHD) risk. | 26838271 |
| Specialty Type - cancer, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Cancer stem cell theory indicates cancer stem cells are the key to promote tumor invasion and metastasis. | 26840020 |
| Pancreatic carcinoma, Secondary Neoplasm | Stem Cell Exhaustion | Polycomb complex protein BMI-1 promotes invasion and metastasis of pancreatic cancer stem cells by activating PI3K/AKT signaling, an ex vivo, in vitro, and in vivo study. | 26840020 |
| Pancreatic carcinoma | Stem Cell Exhaustion | Then, we found that BMI-1 expression was up-regulated in pancreatic cancer stem cells. | 26840020 |
| Pancreatic carcinoma, Secondary Neoplasm | Stem Cell Exhaustion | Knockdown of BMI-1 expression attenuated invasion ability of pancreatic cancer stem cells in Transwell system and liver metastasis capacity in nude mice which were injected CSCs through the caudal vein. | 26840020 |
| Pancreatic carcinoma, Secondary Neoplasm | Stem Cell Exhaustion | We are the first to reveal that BMI-1 could promote invasion and metastasis ability of pancreatic cancer stem cells. | 26840020 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Help-seeking behaviour of patients with haematological malignancies treated with autologous stem cell transplantation. | 26840911 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Patients with haematological malignancies undergoing autologous stem cell transplantation face a life-threatening illness and stressful treatment. | 26840911 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | [Mouthrinse in oral mucositis in the context of allogeneic stem cell transplantation: a qualitative study]. | 26845653 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | Oral mucositis is a common side effect of allogeneic stem cell transplantation and can lead to increased morbidity, mortality and higher costs. | 26845653 |
| Malignant neoplasm of lung, Non-Small Cell Lung Carcinoma, Neoplasms | Stem Cell Exhaustion | A novel paradigm in tumor biology suggests that non-small cell lung cancer (NSCLC) growth is driven by lung cancer stem cell-like cells (LCSCs), but molecular mechanisms regulating tumorigenic and self-renewal potential of LCSCs are still unclear. | 26846105 |
| Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | Our findings testified that CD166(+) cells which were derived from fresh primary NSCLC samples displayed stem cell-like features. | 26846105 |
| Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | The effects and mechanisms of SLC34A2 on tumorigenicity in human non-small cell lung cancer stem cells. | 26846105 |
| Bronchiolitis | Stem Cell Exhaustion | Risk Factor and Clinical Outcome of Bronchiolitis Obliterans Syndrome after Allogeneic Hematopoietic Stem Cell Transplantation. | 26847288 |
| Bronchiolitis Obliterans, Bosnian language | Stem Cell Exhaustion | The development of bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic stem cell transplantation (HSCT) deteriorates patients' quality of life. | 26847288 |
| Sexual Dysfunction, Infertility | Stem Cell Exhaustion | Four hundred and twenty-one adult allogeneic haematopoietic stem cell transplant (HSCT) survivors participated in a cross-sectional study to assess sexual dysfunction and infertility post-transplant. | 26847746 |
| Thrombus, Anemia, Hemolytic, Pancytopenia, Paroxysmal nocturnal hemoglobinuria, Acquired disorder | Stem Cell Exhaustion | PNH is a rare acquired disorder of haematopoietic stem cells, characterised by haemolytic anaemia, pancytopenia and thrombotic events classically involving the venous system. | 26847804 |
| Malignant neoplasm of ovary, Specialty Type - cancer | Stem Cell Exhaustion | Ovarian cancer treatment remains a challenge and targeting cancer stem cells presents a promising strategy. | 26848771 |
| Calcinosis | Stem Cell Exhaustion | Pharmacological Regulation of In Situ Tissue Stem Cells Differentiation for Soft Tissue Calcification Treatment. | 26851078 |
| Hypoxia | Stem Cell Exhaustion | Proinflammatory microenvironment, rather than hypoxia, is correlated with HIF-2alpha activation and promoted osteochondrogenic differentiation of tendon stem/progenitor cells (TSPCs). | 26851078 |
| Calcinosis | Stem Cell Exhaustion | Taken together, these findings reveal the significant role of the tissue stem/progenitor cells fate decision and suggest that pharmacological regulation of HIF-2alpha function is a promising approach for soft tissue calcification treatment. | 26851078 |
| Asthma, Atopy | Stem Cell Exhaustion | Stem Cell Factor and Interleukin-31 Expression: Association with IgE among Egyptian Patients with Atopic and Nonatopic Bronchial Asthma. | 26853551 |
| Asthma, Stem Cell Factor | Stem Cell Exhaustion | Recently, it has been reported that the stem cell factor (SCF) and interleukin-31 (IL-31) may play a major role in bronchial asthma. | 26853551 |
| Asthma, Atopy | Stem Cell Exhaustion | The aim of the current study was to study the association of the stem cell factor and interleukin-31 expression with serum immunoglobulin E among Egyptian patients with atopic and nonatopic bronchial asthma. | 26853551 |
| Cessation of life | Stem Cell Exhaustion | Overall, 38 (78%) of 49 patients are in continuous complete remission, including 13 of 18 after haemopoietic stem cell transplantation, with three deaths in induction, five deaths after haemopoietic stem cell transplantation, and three relapses. | 26853647 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | The role of innovative therapies and haemopoietic stem cell therapy in early T-cell precursor acute lymphoblastic leukaemia needs to be assessed. | 26853647 |
| Viremia | Stem Cell Exhaustion | Viraemia, immunogenicity, and survival outcomes of cytomegalovirus chimeric epitope vaccine supplemented with PF03512676 (CMVPepVax) in allogeneic haemopoietic stem-cell transplantation: randomised phase 1b trial. | 26853648 |
| Systolic dysfunction | Stem Cell Exhaustion | Pre-transplant diastolic but not systolic dysfunction has a negative prognostic impact after allogeneic stem cell transplantation. | 26855153 |
| Specialty Type - cancer | Stem Cell Exhaustion | Interdisciplinary care programme to improve self-management for cancer patients undergoing stem cell transplantation: a prospective non-randomised intervention study. | 26857103 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cell-tumor microenvironment ecosystem is proposed to drive tumor heterogeneity. | 26857534 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Breast cancer stem cells phenotype and plasma cell-predominant breast cancer independently indicate poor survival. | 26857534 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | This study sought to detect the association between breast cancer stem cells and TILs. | 26857534 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Matched cancerous and paracancerous tissues were assembled in a tissue microarray and immunohistochemistry was employed to test expression of breast cancer stem cells (BCSCs) markers. | 26857534 |
| Lymphoma, Non-Hodgkin, Familial, Aggressive Adult Non-Hodgkin Lymphoma | Stem Cell Exhaustion | This phase II study evaluated YM155, a novel small-molecule survivin suppressant, in combination with rituximab in patients with relapsed aggressive B-cell non-Hodgkin lymphoma (NHL) who failed or were not candidates for autologous stem cell transplant (ASCT). | 26857688 |
| Diabetes Mellitus | Stem Cell Exhaustion | Long-Term Insulin Independence in Type 1 Diabetes Mellitus Using a Simplified Autologous Stem Cell Transplant. | 26859103 |
| Diabetes Mellitus, Insulin-Dependent | Stem Cell Exhaustion | Efforts to find a cure for type 1 diabetes have focused on the removal of the autoimmune pathophysiologic substrate, with the use of immunosuppressive regimens including autologous hematopoietic stem cell transplantation (AHSCT). | 26859103 |
| Multiple Myeloma | Stem Cell Exhaustion | [Monomorphic post-transplant T-lymphoproliferative disorder after autologous stem cell transplantation for multiple myeloma]. | 26861102 |
| Post-transplant lymphoproliferative disorder, Lymphoproliferative Disorders | Stem Cell Exhaustion | We report a rare case of T cell type monomorphic post-transplant lymphoproliferative disorders (PTLD) after autologous stem cell transplantation. | 26861102 |
| Multiple Myeloma | Stem Cell Exhaustion | A 53-year-old man with multiple myeloma received autologous stem cell transplantation and achieved a very good partial response. | 26861102 |
| Acute Promyelocytic Leukemia | Stem Cell Exhaustion | [Multiple organ failure presumably due to alkylating agents used as preconditioning drugs for autologous peripheral blood stem cell transplantation in an acute promyelocytic leukemia]. | 26861103 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) are mobilized from the bone marrow and increase in the early phase after ST-elevation myocardial infarction (STEMI). | 26864952 |
| Infected | Stem Cell Exhaustion | The majority of infected patients (n = 75/111) underwent stem cell transplantation (42 autologous, 48 allogeneic, 15 autologous and allogeneic). | 26866481 |
| Specialty Type - cancer, Squamous cell carcinoma of oropharynx | Stem Cell Exhaustion | Impact of Expression of CD44, a Cancer Stem Cell Marker, on the Treatment Outcomes of Intensity Modulated Radiation Therapy in Patients With Oropharyngeal Squamous Cell Carcinoma. | 26867875 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Long noncoding RNA (lncRNA) HOX antisense intergenic RNA (HOTAIR) has recently emerged as a key molecule in many cancers, triggering epithelial-mesenchymal transition (EMT)-mediated cancer stem cell (CSC) formation, but little is known about its significance in EC. | 26868332 |
| Endometrial Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | HOTAIR in relation to epithelial-mesenchymal transition and cancer stem cells in molecular subtypes of endometrial cancer. | 26868332 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Oral acute graft-versus-host disease (aGVHD) is a significant sequelae of allogeneic hematopoietic stem cell transplantation (HSCT). | 26868474 |
| Neoplasms | Stem Cell Exhaustion | We analyzed patients with BC before and after NACT for disseminated tumor cells (DTCs) in the bone marrow(BM); comprehensively characterized circulating tumor cells (CTCs), including stem cell-like CTCs (slCTCs), in blood to prove the effectiveness of treatment on these cells; and correlated these findings with response to therapy, progression-free survival (PFS), and overall survival (OS). | 26868521 |
| Neoplasms | Stem Cell Exhaustion | Although CTCs were eradicated more effectively than DTCs, CTCs detected after treatment seemed to be associated with tumor cells showing tumor stem cell characteristics as well as with resistant tumor cell populations that might indicate a worse outcome in the future. | 26868521 |
| Acute leukemia | Stem Cell Exhaustion | Posaconazole oral suspension primary prophylaxis in acute leukemia and allogeneic stem cell transplant patients: can it be used without measurement of plasma concentration? | 26868905 |
| Acute leukemia | Stem Cell Exhaustion | Overall, 103 acute leukemia (AL) patients submitted to intensive chemotherapy (115 courses) and 46 allogeneic stem cell transplant (allo-SCT) recipients (47 courses) receiving PCZ-susp prophylaxis were considered. | 26868905 |
| Dental Plaque | Stem Cell Exhaustion | Involvement of circulating endothelial progenitor cells in carotid plaque growth and vulnerability. | 26871204 |
| Dental Plaque | Stem Cell Exhaustion | OBJECTIVE The roles of endothelial progenitor cells (EPCs) in the development of carotid plaque are still obscure. | 26871204 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease (GVHD) is one of the major complications after hematopoietic stem cell transplantation and is responsible for post-therapeutic morbidity, mortality, and poor quality of life of recipients. | 26871550 |
| Agammaglobulinemia | Stem Cell Exhaustion | Allogeneic stem cell transplantation for X-linked agammaglobulinemia using reduced intensity conditioning as a model of the reconstitution of humoral immunity. | 26873735 |
| X-linked agammaglobulinemia, Agammaglobulinemia | Stem Cell Exhaustion | We herein report the first case of X-linked agammaglobulinemia (XLA) that underwent allogeneic stem cell transplantation using reduced intensity conditioning (RIC). | 26873735 |
| X-linked agammaglobulinemia, Episode of | Stem Cell Exhaustion | The patient was a 28-year-old Japanese male with XLA who previously had life-threatening infectious episodes and was referred for the possible indication of allogeneic stem cell transplantation. | 26873735 |
| immunoglobulin A | Stem Cell Exhaustion | Regarding immune reconstitution, CD19(+) cells, IgA, and IgM, which were undetectable before allogeneic stem cell transplantation (allo-SCT), started to increase in number 10 days after allo-SCT and continued to increase for more than 1 year. | 26873735 |
| Cutaneous | Stem Cell Exhaustion | Despite aggressive management, including chemotherapy and stem-cell transplantation, most patients died of progressive disease within a few months after the development of cutaneous lesions. | 26874821 |
| Anemia, Hematopoietic stem cells, Dysplasia | Stem Cell Exhaustion | This defect resulted in age-dependent progressive anemia, megakaryocyte dysplasia and loss of hematopoietic stem cell (HSC) quiescence. | 26878232 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | mTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance. | 26878385 |
| Glioblastoma Multiforme Pathway, Adult Glioblastoma | Stem Cell Exhaustion | SOX2 and SOX9 are commonly overexpressed in glioblastoma, and regulate the activity of glioma stem cells (GSCs). | 26878385 |
| Allogeneic Hematopoietic Stem Cell Transplantation, Toxic effect, Sexual function | Stem Cell Exhaustion | Treatment with allogeneic hematopoietic stem cell transplantation (HSCT) is associated with short and long-term toxicities that can result in alterations in sexual functioning. | 26878660 |
| Mycoses | Stem Cell Exhaustion | This case shows that molecular genetic-based methods may be effective for detecting undetermined invasive fungal infections in stem cell transplantation settings. | 26879198 |
| Multiple Myeloma | Stem Cell Exhaustion | High dose melphalan (HDM) and autologous stem cell transplantation (ASCT) retains a central role in the treatment of myeloma. | 26879446 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | Sustaining integrating imatinib and interferon-a into maintenance therapy improves survival of patients with Philadelphia positive acute lymphoblastic leukemia ineligible for allogeneic stem cell transplantation. | 26879808 |
| Lymphoma | Stem Cell Exhaustion | This study was conducted to evaluate its efficacy and optimal dose in Indian patients with relapsed/refractory lymphoma who were unable or unwilling to undergo autologous hematopoietic stem cell transplant. | 26881531 |
| Antilymphocyte Serum | Stem Cell Exhaustion | Autologous Peripheral Blood Stem Cell Transplantation Improves Neural Electrophysiological Function in Patients with ALS. | 26882810 |
| Antilymphocyte Serum | Stem Cell Exhaustion | The present research examined whether autologous peripheral blood stem cell transplantation (APBSCT) could improve neural electrophysiological function in 21 patients with ALS. | 26882810 |
| Antilymphocyte Serum | Stem Cell Exhaustion | 21 patients with ALS were injected with autologous peripheral blood stem cells, and the measurements were assessed prior to APBSCT at 1, 3, and 6 months after transplantation. | 26882810 |
| Acute leukemia | Stem Cell Exhaustion | Impact of cytomegalovirus reactivation on relapse and survival in patients with acute leukemia who received allogeneic hematopoietic stem cell transplantation in first remission. | 26883100 |
| leukemia | Stem Cell Exhaustion | Cytomegalovirus (CMV)-reactivation is associated with graft-vs-leukemia (GVL) effect by stimulating natural-killer or T-cells, which showed leukemia relapse prevention after hematopoietic stem cell transplantation (HSCT). | 26883100 |
| Prostate carcinoma, Secondary Neoplasm | Stem Cell Exhaustion | SREBP-2 promotes stem cell-like properties and metastasis by transcriptional activation of c-Myc in prostate cancer. | 26883200 |
| Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Furthermore, overexpression of SREBP-2 increased the PCa stem cell population, prostasphere-forming ability and tumor-initiating capability, whereas genetic silencing of SREBP-2 inhibited PCa cell growth, stemness, and xenograft tumor growth and metastasis. | 26883200 |
| Secondary Neoplasm, Passive Cutaneous Anaphylaxis | Stem Cell Exhaustion | Collectively, these clinical and experimental results reveal a novel role of SREBP-2 in the induction of a stem cell-like phenotype and PCa metastasis, which sheds light on translational potential by targeting SREBP-2 as a promising therapeutic approach in PCa. | 26883200 |
| Deterioration | Stem Cell Exhaustion | Hematopoietic stem cell transplantation has been found effective in slowing cerebral deterioration and improving long-term survival. | 26883615 |
| Discolored Medical Device Material, Adrenoleukodystrophy | Stem Cell Exhaustion | The purpose of this case report was to describe the multidisciplinary management of red, discolored, pulpally treated primary molars identified in a nine-year-old Russian boy with childhood cerebral X-linked adrenoleukodystrophy preparing for myeloablative conditioning chemotherapy followed by hematopoietic stem cell transplantation. | 26883615 |
| Gastrointestinal Stromal Tumors | Stem Cell Exhaustion | Some authors suggest common origin of gastrointestinal stromal tumors from stem cells, which may show diverse differentiation. | 26884872 |
| Adult Myelodysplastic Syndrome, Acute leukemia | Stem Cell Exhaustion | The efficacy and safety of a new reduced-toxicity conditioning with 4 days of once-daily 100 mg/m(2) intravenous busulfan associated with fludarabine and antithymocyte globulins prior to allogeneic stem cell transplantation in patients with high-risk myelodysplastic syndrome or acute leukemia. | 26885686 |
| Juvenile Myelomonocytic Leukemia, leukemia | Stem Cell Exhaustion | The stem cell character of juvenile myelomonocytic leukemia was confirmed by successful serial transplantation that resulted in leukemia cell propagation for more than one year. | 26888021 |
| Cachexia, Juvenile Myelomonocytic Leukemia | Stem Cell Exhaustion | Key characteristics of juvenile myelomonocytic leukemia were reproduced, including cachexia and clonal expansion of myelomonocytic progenitor cells that infiltrated bone marrow, spleen, liver and, notably, lung. | 26888021 |
| Progeria | Stem Cell Exhaustion | Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation. | 26890144 |
| Heart failure, Hyperbilirubinemia | Stem Cell Exhaustion | The present study focus on patient-inspired ex vivo liver tissue engineering strategy to generate hepatocyte-scaffold composite by combining bone marrow mesenchymal stem cells (BMSCs) derived from cardiac failure patients with secondary hyperbilirubinemia as primers of hepatic differentiation and hepatocyte growth factor (HGF)-enriched sera from same individuals as hepatic inducer. | 26890619 |
| Metabolic Syndrome X | Stem Cell Exhaustion | Black Raspberry Extract Increased Circulating Endothelial Progenitor Cells and Improved Arterial Stiffness in Patients with Metabolic Syndrome: A Randomized Controlled Trial. | 26891216 |
| Arterial Stiffness, Metabolic Syndrome X | Stem Cell Exhaustion | We investigated short-term effects of black raspberry on circulating endothelial progenitor cells (EPCs) and arterial stiffness in patients with metabolic syndrome. | 26891216 |
| Blindness | Stem Cell Exhaustion | Patients develop progressive total bilateral limbal stem cell deficiency, which eventually results in corneal blindness. | 26891374 |
| Hypoplasia | Stem Cell Exhaustion | In addition, siRNA treatment led to longer acquired life span of mutated stem cells compared to controls, less accelerated stem cell differentiation in vitro, reduced proliferation properties, and effective ability in correcting the epithelial hypoplasia, thus giving rise to full thickness stratified and differentiated epithelia. | 26891374 |
| ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 1 | Stem Cell Exhaustion | This study demonstrates the phenotypic correction of mutant stem cells (OMESCs) in EEC syndrome by means of siRNA mediated AS silencing with restoration of function. | 26891374 |
| Refractory Cytopenia of Childhood | Stem Cell Exhaustion | It has been reported that Vhl knock-out mice did not develop RCC, but Vhl knock-out mice with single allele loss of Bap1 in nephron progenitor cells developed RCC, indicating that Bap1 inactivation may be essential in murine renal tumorigenesis. | 26891804 |
| Neoplasms, Childhood Breast Carcinoma | Stem Cell Exhaustion | Circulating Tumor Cells and Tumor Stem Cells Detection in the Peripheral Blood Mononuclear Cells of Breast Cancer. | 26892105 |
| Neoplasms, Childhood Breast Carcinoma, Secondary Neoplasm | Stem Cell Exhaustion | Both CTCs and tumor stem cells (TSCs) could be detected in the PBMC of breast cancer patients; besides, positive expression rate of CTCs might be obviously associated with the clinical stage and metastasis. | 26892105 |
| Prostate carcinoma, Neoplasms, Passive Cutaneous Anaphylaxis | Stem Cell Exhaustion | Subpopulations of prostate cancer (PCa) cells expressing putative stem cell markers possess the ability to promote tumor growth, maintenance, and progression. | 26894647 |
| Prostatic Neoplasms | Stem Cell Exhaustion | This study aimed to evaluate the expression patterns and clinical significance of putative stem cell marker aldehyde dehydrogenase 1 A1 (ALDH1A1) in prostate tumor tissues. | 26894647 |
| Aggressive behavior, Specialty Type - cancer, Passive Cutaneous Anaphylaxis, Neoplastic Cell Transformation | Stem Cell Exhaustion | The significant association between ALDH1A1 expressions with Gleason score indicates the potential role of this protein in PCa tumorigenesis and aggressive behavior; therefore, this cancer stem cell marker can be used as a promising candidate for targeted therapy of PCa, especially those with high Gleason score. | 26894647 |
| Specialty Type - cancer | Stem Cell Exhaustion | In addition, a subpopulation of therapy resistant cells with EMT and cancer stem cell features was identified that was resistant to the standard treatment regimen but sensitive to pemetrexed pretreatment combined with cisplatin. | 26895954 |
| Specialty Type - cancer, Neoplasms, Glioblastoma | Stem Cell Exhaustion | A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo. | 26896279 |
| Specialty Type - cancer, Neoplasms, Malignant Neoplasms | Stem Cell Exhaustion | Many cancers feature cellular hierarchies that are driven by tumor-initiating cancer stem cells (CSC) and rely on complex interactions with the tumor microenvironment. | 26896279 |
| Extrapulmonary Small Cell Carcinoma, Specialty Type - cancer, Squamous cell carcinoma of esophagus | Stem Cell Exhaustion | The p75 neurotrophin receptor (p75NTR) is a cancer stem cell (CSC) marker in esophageal squamous cell carcinoma (ESCC). | 26897248 |
| physiopathological, Lymphoma | Stem Cell Exhaustion | Valvular Dysfunction in Lymphoma Survivors Treated With Autologous Stem Cell Transplantation: A National Cross-Sectional Study. | 26897666 |
| physiopathological | Stem Cell Exhaustion | This study assessed the prevalence and associated risk factors for valvular dysfunction (VD) observed in adult lymphoma survivors (LS) after autologous hematopoietic stem cell transplantation (auto-HCT), and to determine whether anthracycline-containing chemotherapy (ACCT) alone in these patients is associated with VD. | 26897666 |
| Chemotherapy-Induced Febrile Neutropenia | Stem Cell Exhaustion | The role of biosimilar granulocyte colony stimulating factor (GCSF) Zarzio for progenitor cell mobilization and the treatment of therapy-induced neutropenia in adult hematopoietic stem cell transplantation. | 26897866 |
| Chemotherapy-Induced Febrile Neutropenia | Stem Cell Exhaustion | Originator GCSF (Neupogen) has been used to mobilize progenitor stem cells and treat therapy-induced neutropenia in Canadian stem cell transplant settings for years. | 26897866 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | The cancer stem cells (CSCs) represent a minority of tumor cells that are able to proliferate and self-renew and might be responsible for tumor initiation and maintenance. | 26898076 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The MSI2 RNA-binding protein has been demonstrated to have a role in acute myeloid leukaemia and stem cell function, but its role in MDS is unknown. | 26898884 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | MSI2 is required for maintaining activated myelodysplastic syndrome stem cells. | 26898884 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | Conditional deletion of Msi2 in a mouse model of MDS results in a rapid loss of MDS haematopoietic stem and progenitor cells (HSPCs) and reverses the clinical features of MDS. | 26898884 |
| Mantle cell lymphoma | Stem Cell Exhaustion | The MCL-002 (SPRINT) study was a randomised, phase 2 study of patients with mantle cell lymphoma aged 18 years or older at 67 clinics and academic centres in 12 countries who relapsed one to three times, had Eastern Cooperative Oncology Group performance status of 0-2, at least one measurable lesion to be eligible, and who were ineligible for intensive chemotherpy or stem-cell transplantation. | 26899778 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Patients with relapsed or refractory mantle cell lymphoma ineligible for intensive chemotherapy or stem-cell transplantation have longer progression-free survival, with a manageable safety profile when treated with lenalidomide compared with monotherapy investigator's choice options. | 26899778 |
| Colonization | Stem Cell Exhaustion | Impact of Gut Colonization by Antibiotic-Resistant Bacteria on the Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective, Single-Center Study. | 26900084 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | There is also accumulating evidence on the immunomodulatory function of gut microbiota after allogeneic stem cell transplantation (alloSCT) and its impact on graft-versus-host disease (GVHD). | 26900084 |
| Post-transplant lymphoproliferative disorder | Stem Cell Exhaustion | EBV-associated post-transplant lymphoproliferative disease (PTLD) remains an important complication of allogeneic haematopoietic stem cell transplantation (allo-HSCT). | 26901708 |
| homoserine kinase activity, Herpetic whitlow, Communicable Diseases | Stem Cell Exhaustion | The expression of NOD1, NOD2, NLRP1, and NLRP3 was analyzed using real-time RT-PCR in (1) corneas with active infection, history of herpetic stromal keratitis (HSK), chronic allograft rejection, and limbal stem cell deficiency (LSCD), and (2) human corneal cells after lipopolysaccharide (LPS) stimulation. | 26902715 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | We studied the impact of a set of immune cells contained within granulocyte colony-stimulating factor-mobilized peripheral blood stem cell grafts (naive and memory T-cell subsets, B cells, regulatory T cells, invariant natural killer T cells [iNKTs], NK cells, and dendritic cell subsets) in patients (n = 80) undergoing allogeneic stem cell transplantation (SCT), using the composite end point of graft-versus-host disease (GVHD)-free and progression-free survival (GPFS) as the primary end point. | 26903546 |
| Parainfluenza Virus Infections | Stem Cell Exhaustion | DAS181 for Treatment of Parainfluenza Virus Infections in Hematopoietic Stem Cell Transplant Recipients at a Single Center. | 26904972 |
| Respiratory Tract Infections | Stem Cell Exhaustion | Parainfluenza virus (PIV) causes severe respiratory infections in hematopoietic stem cell transplant (HSCT) recipients. | 26904972 |
| Multiple Myeloma | Stem Cell Exhaustion | The efficacy and safety of thalidomide as an initial treatment in myeloma patients who were unsuitable for autologous stem cell transplantation (ASCT), as induction treatment prior to ASCT, or as a maintenance treatment was unclear. | 26906553 |
| LIPC gene | Stem Cell Exhaustion | Those HL patients, who cannot be cured at least with salvage therapy (including autologous haemopoietic stem cell transplantation (auto-HSCT)), have really unfavourable prognosis. | 26907830 |
| Respiratory Syncytial Virus Infections | Stem Cell Exhaustion | Corticosteroid use as adjunct therapy for respiratory syncytial virus infection in adult allogeneic stem cell transplant recipients. | 26909896 |
| Communicable Diseases | Stem Cell Exhaustion | Respiratory syncytial virus (RSV) infection causes significant morbidity and mortality in allogeneic stem cell transplant (allo-SCT) recipients. | 26909896 |
| Aplastic Anemia | Stem Cell Exhaustion | Impact of cyclophosphamide dose of conditioning on the outcome of allogeneic hematopoietic stem cell transplantation for aplastic anemia from human leukocyte antigen-identical sibling. | 26910242 |
| Aplastic Anemia | Stem Cell Exhaustion | The standard conditioning regimen in allogeneic hematopoietic stem cell transplantation (HSCT) for aplastic anemia from a human leukocyte antigen (HLA)-identical sibling has been high-dose cyclophosphamide (CY 200 mg/kg). | 26910242 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Older recipient and donor age were associated with higher incidences of severe graft-versus-host disease (GVHD) and mortality after allogeneic hematopoietic stem cell transplantation from matched sibling donors (MSDs) and matched unrelated donors. | 26910296 |
| Acute lymphocytic leukemia, BCR gene, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | We retrospectively analyzed Japanese registration data of 2,091 patients with acute myeloid leukemia, acute lymphoblastic leukemia (ALL), and myelodysplastic syndrome aged 50 years or older who underwent MSD bone marrow transplantation (BMT) (n = 319), MSD peripheral blood stem cell transplantation (PBSCT) (n = 462), or unrelated CBT (n = 1,310) between 2007 and 2012. | 26910296 |
| RBBP1L1 Protein | Stem Cell Exhaustion | The AdnaTest(r) system was used to enrich epithelial cells in peripheral blood and to detect breast cancer-associated, stem cell-specific or EMT-specific transcripts. | 26910601 |
| Specialty Type - cancer | Stem Cell Exhaustion | Moreover, transcripts specific for cancer stem cells and epithelial mesenchymal transition (EMT) were assessed. | 26910601 |
| Disease | Stem Cell Exhaustion | Human bone marrow mesenchymal stem cells (hBM-MSCs) hold promise for treating incurable diseases and repairing of damaged tissues. | 26910916 |
| Hair follicle structure, Alopecia | Stem Cell Exhaustion | We show that hair follicle stem cell (HFSC) aging causes the stepwise miniaturization of hair follicles and eventual hair loss in wild-type mice and in humans. | 26912707 |
| Aortic Valve Stenosis | Stem Cell Exhaustion | Circulating Endothelial Progenitor Cells and Clinical Outcome in Patients with Aortic Stenosis. | 26913741 |
| Specialty Type - cancer, Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | A national study on conditional survival, excess mortality and second cancer after high dose therapy with autologous stem cell transplantation for non-Hodgkin lymphoma. | 26914167 |
| Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma, Cessation of life, Malignant Neoplasms | Stem Cell Exhaustion | This national population-based study aimed to investigate conditional survival and standardized mortality ratios (SMR) after high-dose therapy with autologous stem-cell transplantation (HDT-ASCT) for non-Hodgkin lymphoma (NHL), and to analyse cause of death, relapses and second malignancies. | 26914167 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Donor cell leukemia (DCL) is a rare complication of hematopoietic stem cell transplantation (HSCT). | 26914843 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Autologous stem cell transplantation (ASCT) has become the mainstay of 1st-line treatment in younger patients with multiple myeloma (MM), but statistical confirmation of its superiority over other therapies, especially in the era of novel agents, is still lacking. | 26915865 |
| Stomach Carcinoma, Specialty Type - cancer, Neoplasms, Malignant Neoplasms | Stem Cell Exhaustion | Cancer stem cells (CSCs) are believed to contribute to the tumor growth in gastric carcinoma (GC), a common lethal malignancy. | 26918728 |
| Exanthema, Mantle cell lymphoma, Fever | Stem Cell Exhaustion | We present the case of a 62-year-old man treated with high-dose chemotherapy and consecutive autologous stem cell transplantation for mantle cell lymphoma, who developed high fever and a rash of the trunk and both axillae 10 days after stem cell transplantation. | 26918962 |
| Specialty Type - cancer, Nasopharyngeal carcinoma | Stem Cell Exhaustion | ISG15 predicts poor prognosis and promotes cancer stem cell phenotype in nasopharyngeal carcinoma. | 26919245 |
| Specialty Type - cancer | Stem Cell Exhaustion | ISG15 overexpression promoted a cancer stem cell phenotype in NPC cells, including increased colony and tumorsphere formation abilities, pluripotency-associated genes expression, and in vivo tumorigenicity. | 26919245 |
| Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, Allogeneic Hematopoietic Stem Cell Transplantation | Stem Cell Exhaustion | Complete neurologic and cognitive recovery after plasmapheresis in a patient with chronic inflammatory demyelinating polyneuropathy after allogeneic hematopoietic stem cell transplantation. | 26919852 |
| neurological complication | Stem Cell Exhaustion | Neurologic complications after allogeneic hematopoietic stem cell transplantation (HSCT) are rare but poorly understood. | 26919852 |
| Ischemia | Stem Cell Exhaustion | Expansion and angiogenic potential of mesenchymal stem cells from patients with critical limb ischemia. | 26921003 |
| CLU protein, human | Stem Cell Exhaustion | Traditional revascularization options are not possible for up to 50% of CLI patients, in which case, the use of cellular therapies, such as bone marrow-derived mesenchymal stem cells (MSCs), hold great promise as an alternative revascularization therapy. | 26921003 |
| Pancytopenia | Stem Cell Exhaustion | Pure Red Cell Aplasia in Major ABO-Mismatched Allogeneic Hematopoietic Stem Cell Transplantation Is Associated with Severe Pancytopenia. | 26921820 |
| Pure Red-Cell Aplasia | Stem Cell Exhaustion | In major ABO-mismatched allogeneic hematopoietic stem cell transplantation (HSCT) persistence of antidonor isohemagglutinins leads to pure red cell aplasia (PRCA). | 26921820 |
| Secondary Graft Failure After Hematopoietic Cell Transplantation | Stem Cell Exhaustion | Two patients (15%) received a second transplant because of persistent pancytopenia/secondary graft failure, 1 (8%) died from secondary graft failure despite a stem cell boost, 1 (8%) did not recover his platelet counts despite RBC/ANC recovery, and 3 patients (23%) died from disease relapse. | 26921820 |
| Venous Thromboembolism | Stem Cell Exhaustion | Management patterns and outcomes in symptomatic venous thromboembolism following allogeneic hematopoietic stem cell transplantation. | 26922092 |
| Venous Thromboembolism, vinyltriethoxysilane | Stem Cell Exhaustion | Experience is limited with regard to antithrombotic therapy in patients with venous thromboembolism (VTE) following allogeneic hematopoietic stem cell transplantation (HSCT). | 26922092 |
| Crohn Disease | Stem Cell Exhaustion | Human Embryonic Stem Cell Therapy in Crohn's Disease: A Case Report. | 26923312 |
| Crohn Disease | Stem Cell Exhaustion | Our study aimed to evaluate the efficacy of human embryonic stem cell therapy in a patient with Crohn's disease. | 26923312 |
| Food intolerance (disorder), Diarrhea, Abdominal Pain | Stem Cell Exhaustion | A 21-year-old male with chief complaints of intolerance to specific foods, abdominal pain, and diarrhea underwent human embryonic stem cell therapy for two months. | 26923312 |
| Crohn Disease | Stem Cell Exhaustion | Human embryonic stem cell therapy might serve as a new optimistic treatment approach for Crohn's disease. | 26923312 |
| Hodgkin Disease | Stem Cell Exhaustion | Engraftment and outcomes following autologous stem cell transplantation in Hodgkin lymphoma patients mobilized with plerixafor. | 26928577 |
| Hodgkin Disease, Childhood Non-Hodgkin Lymphoma, Multiple Myeloma, LIPC gene | Stem Cell Exhaustion | Plerixafor has been used to improve peripheral blood stem cell (PBSC) mobilization in multiple myeloma, non-Hodgkin lymphoma, and very recently in Hodgkin lymphoma (HL) patients. | 26928577 |
| Autoimmune Diseases, Specialty Type - cancer, Primary immune deficiency disorder | Stem Cell Exhaustion | In addition, we computed the prevalence of certain conditions associated with immune dysregulation (stem cell or bone marrow transplantation, solid organ transplantation, HIV infection, primary immunodeficiency, any cancer, and autoimmune diseases). | 26932311 |
| Hyperparathyroidism | Stem Cell Exhaustion | Previous studies have demonstrated that recipient mice of this stem cell-based FGF2 therapy developed secondary hyperparathyroidism and increased bone resorption. | 26934099 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | The lung function score and its components as predictors of overall survival and chronic graft-vs-host disease after allogeneic stem cell transplantation. | 26935611 |
| Li-Fraumeni Syndrome | Stem Cell Exhaustion | We evaluated 241 patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT) at the University of Regensburg Transplant Center between June 1998 and July 2005 in relation to their LFS, FEV1 and cDLCO, before and after HSCT. | 26935611 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | p53 determines prognostic significance of the carbohydrate stem cell marker TF1 (CD176) in ovarian cancer. | 26935926 |
| Specialty Type - cancer | Stem Cell Exhaustion | The oncofoetal Thomsen-Friedenreich (TF1, CD176) epitope is a carbohydrate cancer stem cell (CSC) antigen, and TF1-mediated cancer progression can be widely reversed by anti-TF1 antibodies. | 26935926 |
| Amyotrophic Lateral Sclerosis | Stem Cell Exhaustion | Intraspinal delivery of bone marrow stromal cell-derived neural stem cells in patients with amyotrophic lateral sclerosis: A safety and feasibility study. | 26944143 |
| Antilymphocyte Serum | Stem Cell Exhaustion | Stem cells have been used in several studies with different methodologies to treat patients with ALS. | 26944143 |
| Streptococcal Infections | Stem Cell Exhaustion | Viridans Group Streptococcal Infections in Children After Chemotherapy or Stem Cell Transplantation: A 10-year Review From a Tertiary Pediatric Hospital. | 26945409 |
| Malignant Neoplasms | Stem Cell Exhaustion | The aim of this study was to describe the characteristics, outcome, and resistance patterns of children with VGS bacteremia (VGSB) undergoing treatment of malignancy or hematopoietic stem cell transplant. | 26945409 |
| Specialty Type - cancer, Carcinoma, Transitional Cell | Stem Cell Exhaustion | Expression of Cancer Stem Cell Markers OCT4 and CD133 in Transitional Cell Carcinomas. | 26945449 |
| Failure, Neoplasms, Secondary Neoplasm, Malignant neoplasm of urinary bladder | Stem Cell Exhaustion | Treatment failure, recurrence, and metastasis in bladder cancer are attributed to a subset of tumor cells expressing cancer stem cell (CSC) markers. | 26945449 |
| Malignant Neoplasms | Stem Cell Exhaustion | Further research is needed to determine whether these malignancies originate from two different cell clones or arise from the same pluripotent hematopoietic stem cell. | 26946772 |
| Hepatitis C Virus Positive, Multiple Myeloma | Stem Cell Exhaustion | Outcomes in hepatitis C virus seropositive lymphoma and myeloma patients after autologous stem cell transplantation. | 26950376 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Kinetics of versican-expressing macrophages in bone marrow after cord blood stem cell transplantation for treatment of acute myelogenous leukaemia. | 26951084 |
| Gain, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | To determine versican-producing cells in normocellular bone marrow and to evaluate chronological alteration in the number of versican-producing macrophages in bone marrow of patients with acute myelogenous leukaemia (AML) after cord blood stem cell transplantation (CBSCT) to gain insight in the significance of versican in recovery of haematopoiesis. | 26951084 |
| Hematologic Neoplasms | Stem Cell Exhaustion | The Immediacy of Illness and Existential Crisis: Patients' lived experience of under-going allogeneic stem cell transplantation for haematological malignancy. | 26952683 |
| Hematologic Neoplasms | Stem Cell Exhaustion | This paper reports a study exploring the lived experience of fifteen men and women treated with allogeneic stem cell transplant (SCT) for haematological malignancy. | 26952683 |
| Neoplasms | Stem Cell Exhaustion | Thereby we measured levels of angiogenic growth factors, tumor perfusion, circulating endothelial cells (CEC), circulating endothelial progenitor cells (CEP) and tumor endothelial markers (TEM) in patients during the course of therapy with antiangiogenic agents, and correlated them with the time to antiangiogenic progression (aTTP). | 26956051 |
| Relapsing course, Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | Relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) in those unfit or ineligible for autologous stem cell transplantation is associated with a poor outcome and new treatment approaches are needed. | 26956150 |
| RAPH1 gene | Stem Cell Exhaustion | Most cases of EBV-related LPD after hematopoietic stem cell transplantation consist of EBV-positive B-cell LPD, and, to our knowledge, de novo EBV-positive T-cell LPD subsequent to transplantation has not been previously reported. | 26960588 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | HMAs are currently the first therapeutic choice for MDS patients who are not candidates for allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 26960675 |
| Aspergillus Galactomannan Antigen Test, Aspergillosis | Stem Cell Exhaustion | Changes of serum aspergillus galactomannan during hematopoietic stem cell transplantation in children with prior invasive aspergillosis. | 26960808 |
| Multiple Myeloma | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplantation (auto-HCT) is considered a standard therapy for transplant-eligible patients with multiple myeloma, while allogeneic HCT (allo-HCT) is controversial. | 26961137 |
| Li-Fraumeni Syndrome | Stem Cell Exhaustion | LFS was superior with MSD (P < .001), BM as graft source (P = .001), and performance scores > 90 (P = .03) compared with unrelated or mismatched peripheral blood stem cells donors and recipients with lower performance scores. | 26964698 |
| Philadelphia chromosome positive chronic myelogenous leukemia, BCR gene, Myeloid Leukemia, Chronic, Acute lymphocytic leukemia | Stem Cell Exhaustion | Concomitant use after hematopoietic stem cell transplantation (HSCT) for chronic myeloid leukemia (CML) or Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (ALL) may therefore result in a pharmacokinetic interaction. | 26965514 |
| Multiple Myeloma | Stem Cell Exhaustion | Granulocyte-like myeloid derived suppressor cells (G-MDSC) are increased in multiple myeloma and are driven by dysfunctional mesenchymal stem cells (MSC). | 26967390 |
| Juvenile Xanthogranuloma, Histiocytosis, Langerhans-Cell | Stem Cell Exhaustion | Langerhans cell histiocytosis (LCH) and juvenile xanthogranuloma (JXG) are thought to originate from a common stem cell precursor, with divergent differentiation under different microenvironmental conditions. | 26968131 |
| Neutropenia, Hematologic Neoplasms | Stem Cell Exhaustion | We performed a monocentric retrospective study including all patients with hematological malignancy in a ten-year period, to identify factors related to the outcome for the whole cohort and for patients with allogeneic hematopoietic stem cell transplantation (HSCT), neutropenia, or those requiring invasive mechanical ventilation (IMV). | 26968953 |
| Acute leukemia | Stem Cell Exhaustion | However, the risk of such complications in childhood acute leukemia survivors who received either central nervous system irradiation or hematopoietic stem cell transplantation is less described. | 26969082 |
| Experimental Organism Malignant Hepatocholangiocellular Carcinoma | Stem Cell Exhaustion | The expression of arginase-1, keratin (K) 8 and K18 in combined hepatocellular-cholangiocarcinoma, subtypes with stem-cell features, intermediate-cell type. | 26969740 |
| Neoplasms, Experimental Organism Malignant Hepatocholangiocellular Carcinoma | Stem Cell Exhaustion | The WHO classification describes that combined hepatocellular-cholangiocarcinoma, subtypes with stem-cell features, intermediate-cell subtype (CHC-INT) is composed of tumour cells with features intermediate between hepatocytes and cholangiocytes. | 26969740 |
| Nephroblastoma, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Wilms Tumor 1 Expression and Pre-emptive Immunotherapy in Patients with Acute Myeloid Leukemia Undergoing an Allogeneic Hemopoietic Stem Cell Transplantation. | 26970379 |
| Nephroblastoma, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Minimal residual disease (MRD) was monitored by Wilms tumor 1 (WT1) expression in 207 patients with acute myeloid leukemia (AML) after an allogeneic hemopoietic stem cell transplantation (HSCT) as a trigger to initiate pre-emptive immunotherapy (IT) with cyclosporin discontinuation and/or donor lymphocyte infusion. | 26970379 |
| Primary Myelofibrosis | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation remains the sole curative option for myelofibrosis. | 26970380 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Risk of graft-versus-host disease with rituximab-containing conditioning regimens in allogeneic hematopoietic stem cell transplant. | 26970572 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease represents a major cause of morbidity and mortality in allogeneic hematopoietic stem cell transplant patients. | 26970572 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | The purpose of this retrospective cohort study was to evaluate the efficacy of rituximab-containing conditioning regimens in decreasing graft-versus-host disease in allogeneic hematopoietic stem cell transplant patients who received standardized tacrolimus-based graft-versus-host disease prophylaxis regimens. | 26970572 |
| Cessation of life, Acute GVH disease | Stem Cell Exhaustion | When restricting the analysis to recipients of peripheral blood hematopoietic stem cell transplants, the RTX group had a higher incidence of grade II-IV acute graft-versus-host disease, relapse, or death prior to day 100 (55% vs. 36%, p = 0.037). | 26970572 |
| Acute GVH disease | Stem Cell Exhaustion | Inhibition of antigen presentation by B cells with rituximab-based conditioning regimens does not appear to reduce the incidence of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplant recipients. | 26970572 |
| Multiple Myeloma | Stem Cell Exhaustion | Health-related physical fitness in patients with multiple myeloma or lymphoma recently treated with autologous stem cell transplantation. | 26971299 |
| Decompensated cirrhosis of liver | Stem Cell Exhaustion | Phase 1-2 pilot clinical trial in patients with decompensated liver cirrhosis treated with bone marrow-derived endothelial progenitor cells. | 26972567 |
| Decompensated cirrhosis of liver | Stem Cell Exhaustion | The aim of this nonrandomized, open label, phase 1 clinical trial was to evaluate the safety and the feasibility of the treatment with autologous bone marrow-derived endothelial progenitor cells (EPC) in decompensated liver cirrhosis. | 26972567 |
| Hematologic Neoplasms | Stem Cell Exhaustion | A novel reduced intensity conditioning regimen for patients with high-risk hematological malignancies undergoing allogeneic stem cell transplantation. | 26974271 |
| Thyroid dysfunction | Stem Cell Exhaustion | Poor growth, thyroid dysfunction and vitamin D deficiency remain prevalent despite reduced intensity chemotherapy for hematopoietic stem cell transplantation in children and young adults. | 26974276 |
| Congenital Abnormality, HIV Infections | Stem Cell Exhaustion | Hematopoietic stem cells (HSCs) and multipotent hematopoietic progenitor cells (HPCs) give rise to all blood and immune cells, and in HIV infection, hematological abnormalities frequently occur in patients. | 26974413 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Aldehyde dehydrogenase 1 (ALDH1) has been identified as a breast cancer stem cell marker, but its value as a predictor of prognosis and chemoresistance is controversial. | 26975188 |
| Primary central nervous system lymphoma, Failure, Graft failure | Stem Cell Exhaustion | Immunocompetent adults with histologically confirmed PCNSL after experiencing high-dose methotrexate-based chemotherapy failure who were not eligible for or had experienced high-dose chemotherapy with autologous stem-cell transplant failure were included. | 26976424 |
| Acute leukemia | Stem Cell Exhaustion | Impact of conditioning intensity in T-replete haplo-identical stem cell transplantation for acute leukemia: a report from the acute leukemia working party of the EBMT. | 26980295 |
| Complement Membrane Attack Complex, Acute leukemia | Stem Cell Exhaustion | Increasing numbers of patients are receiving haplo-identical stem cell transplantation (haplo-SCT) for treatment of acute leukemia with reduced intensity (RIC) or myeloablative (MAC) conditioning regimens. | 26980295 |
| Huntingtons Disease Pathway | Stem Cell Exhaustion | Genomic Instability Associated with p53 Knockdown in the Generation of Huntington's Disease Human Induced Pluripotent Stem Cells. | 26982737 |
| HD Term Type | Stem Cell Exhaustion | We generated induced pluripotent stem cells (iPSC) from primary dermal fibroblasts of 5 patients with HD and 5 control subjects. | 26982737 |
| Prostate carcinoma | Stem Cell Exhaustion | Prostate Stem Cell Antigen Expression in Radical Prostatectomy Specimens Predicts Early Biochemical Recurrence in Patients with High Risk Prostate Cancer Receiving Neoadjuvant Hormonal Therapy. | 26982980 |
| Lymphohistiocytosis, Hemophagocytic | Stem Cell Exhaustion | When evaluating the efficacy of steroid pulse therapy according to the ferritin level and proportion of hemophagocytic macrophages among patients undergoing bone marrow or peripheral blood stem cell transplantation, both values were higher in responders than in non-responders. | 26984072 |
| Lymphohistiocytosis, Hemophagocytic | Stem Cell Exhaustion | Thus, our results imply that the use of ferritin levels in combination with the proportion of hemophagocytic macrophages may be useful for the early detection of potential hemophagocytic syndrome after hematopoietic stem cell transplantation. | 26984072 |
| Specialty Type - cancer, Squamous cell carcinoma of esophagus | Stem Cell Exhaustion | p75 neurotrophin receptor expression is a characteristic of the mitotically quiescent cancer stem cell population present in esophageal squamous cell carcinoma. | 26984177 |
| Extrapulmonary Small Cell Carcinoma, CD44 Positive | Stem Cell Exhaustion | Real-time PCR analysis of sorted fractions of ESCC cell lines (KYSE cells) revealed that stem cell-related genes (Nanog, p63 and Bmi-1) and epithelial-mesenchymal transition (EMT)-related genes (N-cadherin and fibronectin) were expressed at significantly higher levels in the p75NTR-positive fractions than in the CD44-positive or CD90-positive fractions. | 26984177 |
| Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | Mitotically quiescent cancer stem cells (CSC) are hypothesized to exhibit a more aggressive phenotype involving greater therapeutic resistance and metastasis. | 26984177 |
| Transplant-Related Squamous Cell Carcinoma, Multiple Myeloma | Stem Cell Exhaustion | Edentulism and transplant-associated complications in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation. | 26984247 |
| Graft-vs-Host Disease, Acute GVH disease, Herpes | Stem Cell Exhaustion | Human herpes virus type 6 can reactivate in patients after allogeneic stem cell transplantation and has been associated with serious sequelae such as delayed engraftment and an increased risk of developing acute graft-versus-host disease (GVHD). | 26984480 |
| Herpesviridae | Stem Cell Exhaustion | This study investigated human herpes virus type 6 (HHV-6) reactivation within 60 days of transplantation in stem cell transplants utilizing single umbilical cord blood, double umbilical cord blood, or umbilical cord blood plus haploidentical stem cells. | 26984480 |
| Diabetes | Stem Cell Exhaustion | Pluripotent stem cell therapy for diabetes relies on the safety as well as the quality of derived insulin-producing cells. | 26987352 |
| Neutropenia, Poikiloderma | Stem Cell Exhaustion | Generation of poikiloderma with neutropenia (PN) induced pluripotent stem cells (iPSCs). | 26987923 |
| Adult T-Cell Lymphoma/Leukemia, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Stem Cell Exhaustion | There are few therapeutic options for patients with T-cell acute lymphoblastic leukemia (T-ALL) who have recurrent disease after initial matched sibling hematopoietic stem cell transplantation. | 26990138 |
| Adult T-Cell Lymphoma/Leukemia, leukemia | Stem Cell Exhaustion | While a second hematopoietic stem cell transplant (HSCT) from a haploidentical donor offers the conceptual possibility of greater graft versus leukemia effect, there is minimal literature to describe the efficacy of this approach in recurrent pediatric T-ALL. | 26990138 |
| Hyperplasia | Stem Cell Exhaustion | Cyclosporine-induced sebaceous hyperplasia in a hematopoetic stem cell transplant patient: delayed onset of a common adverse event. | 26990469 |
| Saint Helena Islands, Hyperplasia | Stem Cell Exhaustion | Cyclosporine-induced sebaceous hyperplasia (SH) is a well-documented entity, occurring in up to 30% of renal transplant patients treated with cyclosporine and has also been reported to occur following heart or hematopoetic stem cell transplantation (HCST). | 26990469 |
| Communicable Diseases | Stem Cell Exhaustion | We describe an outbreak of respiratory syncytial virus (RSV) infection on a hematology ward without allogeneic stem cell transplant patients. | 26990584 |
| Kounis Syndrome | Stem Cell Exhaustion | In the case of a 46-year-old male patient who - for the first time in his life - had two episodes of oral allergic syndrome upon kiwi consumption after having received myeloablative hematopoietic stem cell transplantation (HCT) from his kiwi-allergic sister, we aimed to clarify the origin of allergen reactive cells in the donor. | 26990607 |
| Low-grade intraurothelial neoplasia, Carcinoma, Transitional Cell | Stem Cell Exhaustion | Flat Intraurothelial Neoplasia Exhibiting Diffuse Immunoreactivity for CD44 and Cytokeratin 5 (Urothelial Stem Cell/Basal Cell Markers): A Variant of Intraurothelial Neoplasia Commonly Associated With Muscle-invasive Urothelial Carcinoma. | 26990746 |
| Multiple Myeloma | Stem Cell Exhaustion | Single versus tandem high-dose melphalan followed by autologous blood stem cell transplantation in multiple myeloma: long-term results from the phase III GMMG-HD2 trial. | 26990892 |
| Colorectal Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Role of cancer stem cells in racial disparity in colorectal cancer. | 26990997 |
| Specialty Type - cancer | Stem Cell Exhaustion | Totally implanted access ports (PACs) are valuable tools for the treatment of patients with cancer because they ease the administration of chemotherapy, stem cells, and supportive care by reducing the rate of peripheral vein punctures. | 26991711 |
| Post-Treatment Lyme Disease Syndrome | Stem Cell Exhaustion | All solid organ or allogeneic stem cell transplant recipients with PTLDs and exfoliative cytology specimens from 1987 to 2011 were identified. | 26992116 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | The achievement of complete response (CR) significantly correlates with a better clinical outcome in multiple myeloma (MM) patients treated with autologous stem cell transplant (ASCT). | 26992692 |
| Neoplasms, Squamous cell carcinoma of the head and neck, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Stem Cell Exhaustion | Significance of endothelial progenitor cells (EPC) for tumorigenesis of head and neck squamous cell carcinoma (HNSCC): possible marker of tumor progression and neovascularization? | 26993659 |
| Neoplasms | Stem Cell Exhaustion | The aim of our study was to investigate the neovascularization capacity by endothelial progenitor cells (EPC) in tumor patient as a possible predictor for tumor progression and tumor stage. | 26993659 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Gastrointestinal graft-versus-host-disease (GI-GVHD) is a major cause of nonrelapse mortality after hematopoietic stem cell transplantation (HSCT) necessitating endoscopic examinations and biopsies for diagnosis. | 26995779 |
| Meningitis | Stem Cell Exhaustion | A 35-day-old female with severe combined immunodeficiency developed cytomegalovirus (CMV) meningitis before undergoing hematopoietic stem cell transplantation. | 26996725 |
| Secondary malignant neoplasm of liver, Neoplasms | Stem Cell Exhaustion | The biliary/stem cell marker-positive group exhibited poor tumor differentiation, increased frequency of portal vein invasion and/or intrahepatic metastasis, and highly proliferative activity. | 26997435 |
| Secondary malignant neoplasm of liver, Neoplasms | Stem Cell Exhaustion | In contrast, the biliary/stem cell marker-negative and Wnt/b-catenin signaling-related marker-negative group exhibited better tumor differentiation, a decreased frequency of portal vein invasion and/or intrahepatic metastasis, and less proliferative activity. | 26997435 |
| palladium | Stem Cell Exhaustion | Our results suggest that the simultaneous administration of E2B with stem cell-derived DA progenitors can enhance the efficacy of cell transplantation therapy for PD. | 26997644 |
| Aspergillosis | Stem Cell Exhaustion | Pulmonary invasive aspergillosis (IA) is a major clinical problem in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 26998687 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | Does quality of life impact the decision to pursue stem cell transplantation for elderly patients with advanced MDS? | 26999469 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | The factors that influence utilization of reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (HCT) among medically fit older patients with advanced myelodysplastic syndromes (MDS) are largely unknown. | 26999469 |
| Multiple Myeloma | Stem Cell Exhaustion | The Intergroupe Francophone du Myelome conducted a randomized trial to compare bortezomib-thalidomide-dexamethasone (VTD) with bortezomib-cyclophosphamide-dexamethasone (VCD) as induction before high-dose therapy and autologous stem cell transplantation (ASCT) in patients with newly diagnosed multiple myeloma. | 27002117 |
| Schistosoma mansoni | Stem Cell Exhaustion | Here, we demonstrate that somatic stem cells in Schistosoma mansoni are biased towards generating a population of cells expressing factors associated exclusively with the schistosome host-parasite interface, a structure called the tegument. | 27003592 |
| Asherman Syndrome, Atrophic endometrium | Stem Cell Exhaustion | Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman's syndrome and endometrial atrophy: a pilot cohort study. | 27005892 |
| Asherman Syndrome, Atrophic endometrium | Stem Cell Exhaustion | Could cell therapy using autologous peripheral blood CD133+ bone marrow-derived stem cells (BMDSCs) offer a safe and efficient therapeutic approach for patients with refractory Asherman's syndrome (AS) and/or endometrial atrophy (EA) and a wish to conceive? | 27005892 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Leukemic Stem Cell Quantification in Newly Diagnosed Patients With Chronic Myeloid Leukemia Predicts Response to Nilotinib Therapy. | 27006491 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Leukemic stem cells (LSCs) may harbor important resistance to tyrosine kinase inhibitors in chronic myelogenous leukemia (CML). | 27006491 |
| Hodgkin Disease | Stem Cell Exhaustion | Updated Efficacy and Safety Data From the AETHERA Trial of Consolidation With Brentuximab Vedotin After Autologous Stem Cell Transplant (ASCT) in Hodgkin Lymphoma Patients at High Risk of Relapse. | 27007008 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Resistance of leukemia stem cells (LSCs) to chemotherapy in patients with acute myeloid leukemia (AML) causes relapse of disease. | 27008269 |
| Specialty Type - cancer | Stem Cell Exhaustion | Hedgehog (Hh) signaling plays a critical role in the maintenance and differentiation of cancer stem cells. | 27008269 |
| leukemia | Stem Cell Exhaustion | Targeting GLI1 Suppresses Cell Growth and Enhances Chemosensitivity in CD34+ Enriched Acute Myeloid Leukemia Progenitor Cells. | 27008269 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The purpose of the present study is to investigate the role of GLI1, the transcriptional activator of Hh signaling, in AML progenitor cells and to explore the anti-AML effects of GLI small-molecule inhibitor GANT61. | 27008269 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The expression of GLI1 mRNA and protein were examined in AML progenitor cells and normal cells. | 27008269 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The proliferation, colony formation, apoptosis and differentiation of AML progenitor cells were also analyzed in the presence of GANT61. | 27008269 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The present findings suggested that Hh signaling was activated in AML progenitor cells. | 27008269 |
| Malignant neoplasm of stomach, Specialty Type - cancer | Stem Cell Exhaustion | Antitumor activity and inhibitory effects on cancer stem cell-like properties of Adeno-associated virus (AAV) -mediated Bmi-1 interference driven by Bmi-1 promoter for gastric cancer. | 27009837 |
| Neoplasms | Stem Cell Exhaustion | These results suggest that Ad-Bmi-1i not only inhibits tumor growth and stem cell-like phenotype by inducing cellular senescence directly, but also has an indirect anti-tumor activity by anti-angiogenesis effects via regulating PTEN/AKT/VEGF pathway. | 27009837 |
| Malignant Neoplasms | Stem Cell Exhaustion | Bmi-1 is aberrantly activated in various cancers and plays a vital role in maintaining the self-renewal of stem cells. | 27009837 |
| Tissue injury | Stem Cell Exhaustion | Fibrocytes are bone marrow-derived progenitor cells that co-express markers of leukocytes and fibroblasts and are released into the circulation in the context of tissue injury. | 27012475 |
| Kaposi Sarcoma | Stem Cell Exhaustion | A case report of immunosuppression-related Kaposi's sarcoma after autologous stem cell transplantation. | 27012530 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | Autologous stem cell transplantation in first complete remission may not extend progression-free survival in patients with peripheral T cell lymphomas. | 27012928 |
| Acute GVH disease, Lymphoma | Stem Cell Exhaustion | Circulating miRNA panel for prediction of acute graft-versus-host disease in lymphoma patients undergoing matched unrelated hematopoietic stem cell transplantation. | 27013207 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Acute graft-versus-host disease (aGVHD) results in significant morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 27013207 |
| Neoplasms, leukemia | Stem Cell Exhaustion | Aldehyde dehydrogenase 1 (ALDH1) consists of a family of intracellular enzymes, highly expressed in stem cells populations of leukemia and some solid tumors. | 27015121 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Long-term follow-up of patients with acute myeloid leukemia surviving and free of disease recurrence for at least 2 years after autologous stem cell transplantation: A report from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. | 27018549 |
| Failure, leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Leukemia recurrence is a major cause of treatment failure after autologous stem cell transplantation for acute myeloid leukemia (AML). | 27018549 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The results of the current analysis indicate that late recurrences remain a major concern after autologous stem cell transplantation among patients with AML, indicating the need for close monitoring of minimal residual disease and additional leukemic control measures after transplantation. | 27018549 |
| Lung Injury, Type-II Pneumocytes | Stem Cell Exhaustion | Alveolar type II (ATII) cells act as progenitor cells in the adult lung, contributing to alveolar repair during pulmonary injury. | 27020420 |
| Diabetes, Dilated Cardiomyopathy Pathway | Stem Cell Exhaustion | Efficacy of CD34+ Stem Cell Therapy in Nonischemic Dilated Cardiomyopathy Is Absent in Patients With Diabetes but Preserved in Patients With Insulin Resistance. | 27025690 |
| Dilated Cardiomyopathy Pathway | Stem Cell Exhaustion | The present study is the first clinical study directly evaluating the effects of altered glucose metabolism on the efficacy of CD34(+) stem cell therapy in patients with nonischemic dilated cardiomyopathy. | 27025690 |
| Heart failure | Stem Cell Exhaustion | The results offer critical insights into the physiology of stem cell mobilization in heart failure and possibly an explanation for the often conflicting results obtained with stem cell therapy for heart failure. | 27025690 |
| Heart failure | Stem Cell Exhaustion | This finding could serve as a useful tool when selecting heart failure patients for future clinical studies in the field of stem cell therapy. | 27025690 |
| Primary Myelofibrosis | Stem Cell Exhaustion | Thirty consecutive patients underwent hematopoietic stem cell transplantation for myelofibrosis (MF) at our institution. | 27025789 |
| Late Relapse of Acute Myeloid Leukemia, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Chemotherapy versus Hypomethylating Agents for the Treatment of Relapsed Acute Myeloid Leukemia and Myelodysplastic Syndrome after Allogeneic Stem Cell Transplant. | 27026249 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Allogeneic stem cell transplantation (allo-SCT) is a potentially curative treatment for high-risk acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). | 27026249 |
| Heart Diseases | Stem Cell Exhaustion | Four patients proceeded to an allogeneic stem cell transplant including two with pre-existing cardiac disease. | 27028202 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Allogeneic stem cell transplantation (allo-SCT) has the potential to induce long-term remission in multiple myeloma (MM), but the role of allo-SCT in MM is controversial due to the high rate of treatment-related mortality (TRM). | 27028304 |
| Neoplasms | Stem Cell Exhaustion | Tumor tissue samples were obtained intra-operatively and cultured in neural stem cell conditions containing growth factors. | 27028405 |
| hepatotoxin | Stem Cell Exhaustion | SOS rates were 3% when GO was administered at doses <=6 mg/m(2) as monotherapy or with non-hepatotoxic agents; 28% when administered with 6-thioguanine, a hepatotoxic agent; 15% when administered as monotherapy at doses at a dose of 9 mg/m(2), and between 15% and 40% if a stem cell transplant (SCT) was performed within 3 months of GO administration. | 27030962 |
| Neoplasms | Stem Cell Exhaustion | Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation for Atypical Teratoid/Rhabdoid Tumor. | 27034140 |
| Atypical Teratoid Rhabdoid Tumor | Stem Cell Exhaustion | We prospectively evaluated the effectiveness of tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT) in improving the survival of patients with atypical teratoid/rhabdoid tumors while reducing the risks of late adverse effects from radiotherapy (RT). | 27034140 |
| Hepatic Veno-Occlusive Disease, Spondylo-ocular syndrome | Stem Cell Exhaustion | Hepatic sinusoidal obstruction syndrome (SOS) is a life-threatening syndrome that generally occurs as a complication after hematopoietic stem cell transplantation or, less commonly, after conventional chemotherapy. | 27034141 |
| Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | Cancer stem cells are responsible for the development, metastasis, recurrence, and drug resistance of cancer. | 27034262 |
| Multiple Myeloma | Stem Cell Exhaustion | Here, we profiled the myeloma B-cell immunome both to explore its predictive role in the context of autologous and allogeneic hematopoietic stem cell transplantation (HSCT) and to identify novel immunotherapeutic targets. | 27034429 |
| Graft-vs-Host Disease, leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | High CD3+ and CD34+ peripheral blood stem cell grafts content is associated with increased risk of graft-versus-host disease without beneficial effect on disease control after reduced-intensity conditioning allogeneic transplantation from matched unrelated donors for acute myeloid leukemia - an analysis from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. | 27036034 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Inconsistent results have been reported regarding the influence of graft composition on the incidence of graft versus host disease (GVHD), disease control and survival after reduced-intensity conditioning (RIC) allogeneic peripheral blood stem cell transplantation (allo-PBSCT). | 27036034 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Alternatively, novel graft-versus-host disease prophylaxis regimens are needed to substantially impact graft-versus-host disease-free, relapse-free survival with the use of peripheral blood stem cell. | 27036159 |
| Tumor necrosis, Trial Disease Assessments Domain, melphalan/prednisone protocol | Stem Cell Exhaustion | We here aimed to explore associations among gene polymorphisms of tumor necrosis factor alpha (TNFa), nitric oxide synthesis 3 (NOS3) and multi-drug resistance 1 (MDR1), clinical parameters, prognosis and survival in MM patients treated with VAD (vincristine-adriamycine-dexamethasone), MP (mephalane-prednisolone), autolougus stem cell transplantation (ASCT), BODEC (bortezomib-dexamethasone-cyclophosphamide) and TD (thalidomide-dexamethasone). | 27039718 |
| PAFAH1B1 wt Allele, Cytopenia, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Primary myelodysplastic syndrome (MDS) is an acquired clonal disorder of myeloid progenitor cells, characterized by peripheral cytopenias in the presence of hypercellular marrow with dysplastic features. | 27039802 |
| Hematological Disease, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Acute myeloid leukemia (AML) is a clonal hematopoietic disorder resulting from genetic alterations in normal hematopoietic stem cells. | 27039804 |
| Lymphoma | Stem Cell Exhaustion | Efficacy of Pharmacokinetics-Directed Busulfan, Cyclophosphamide, and Etoposide Conditioning and Autologous Stem Cell Transplantation for Lymphoma: Comparison of a Multicenter Phase II Study and CIBMTR Outcomes. | 27040394 |
| Childhood Breast Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Triple negative breast cancer (TNBC) is a heterogeneous disease and is associated with the cancer stem cell (CSC), basal-like, and BRCA1 function deficient (BRCAness) subtypes. | 27041672 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Autologous stem cell transplantation is a standard treatment in multiple myeloma (MM). | 27041692 |
| Hodgkin Disease | Stem Cell Exhaustion | Autologous stem cell transplantation for patients aged 60 years or older with refractory or relapsed classical Hodgkin's lymphoma: a retrospective analysis from the French Society of Bone Marrow Transplantation and Cell Therapies (SFGM-TC). | 27042842 |
| Hodgkin Disease | Stem Cell Exhaustion | This report retrospectively analyzed the outcome of 91 patients aged 60 years or older with refractory/relapsed (R/R) classical Hodgkin's lymphoma (cHL) who underwent autologous stem cell transplantation (ASCT) between 1992 and 2013 and were reported to the French Society of Bone Marrow Transplantation and Cell Therapies registry. | 27042842 |
| Chronic graft-versus-host disease | Stem Cell Exhaustion | Accelerated bone mineral density loss (BMDL) occurs early after allogeneic stem cell transplantation (SCT) and is related to factors such as steroids and chronic GvHD. | 27042843 |
| Acute lymphocytic leukemia, BCR gene | Stem Cell Exhaustion | The prognostic relevance of cytogenetics at diagnosis on the outcome of allogeneic hematopoietic stem cell transplantation (alloHCT) for adult acute lymphoblastic leukemia (ALL) remains unclear. | 27044907 |
| Lupus Erythematosus | Stem Cell Exhaustion | Rapamycin reverses the senescent phenotype and improves immunoregulation of mesenchymal stem cells from MRL/lpr mice and systemic lupus erythematosus patients through inhibition of the mTOR signaling pathway. | 27048648 |
| Encephalitis, St. Louis, Adolescent Behavior | Stem Cell Exhaustion | We have shown that bone marrow (BM)-derived mesenchymal stem cells (BM-MSCs) from SLE patients exhibit senescent behavior and are involved in the pathogenesis of SLE. | 27048648 |
| Multiple Myeloma | Stem Cell Exhaustion | The clinical impact of thalidomide maintenance after autologous stem cell transplantation in patients with newly diagnosed multiple myeloma in real clinical practice of Korea. | 27052989 |
| Malignant neoplasm of stomach, Specialty Type - cancer | Stem Cell Exhaustion | Dose-escalation study for the targeting of CD44v+ cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205). | 27055559 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells (CSCs) have enhanced mechanisms of protection from oxidative stress. | 27055559 |
| Haiti | Stem Cell Exhaustion | The patient group consisted of 80 renal transplant (RT) recipients, 35 stem cell transplant (SCT) recipients, 13 newborns, seven heart transplant (HT) recipients and one pregnant woman. | 27058329 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We compared postremission treatment with chemotherapy and hematopoietic stem cell transplantation (HSCT) in 169 FLT3-ITDmut intermediate cytogenetic risk AML patients with allelic ratio evaluable at diagnosis who achieved first complete remission (CR1) with induction therapy. | 27058617 |
| Blindness, Limbal stem cell deficiency | Stem Cell Exhaustion | Corneal blindness due to limbal stem-cell deficiency can be treated by transplantation of cultivated limbal epithelial stem cells (LESCs). | 27058829 |
| Liver carcinoma, Specialty Type - cancer, Hollings Cancer Center | Stem Cell Exhaustion | However, the role of miR-452, especially in regulating cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) remains ambiguous. | 27058905 |
| Encephalitis, St. Louis | Stem Cell Exhaustion | IFNa, IFNb, IL-12p40, and stem cell factor/c-Kit ligand were increased in SLE patients only (P < 0.05). | 27059145 |
| Encephalitis, St. Louis | Stem Cell Exhaustion | ANA-positive healthy individuals exhibit dysregulation in multiple immune pathways yet differ from SLE patients by the absence of elevated IFNs, BLyS, IL-12p40, and stem cell factor/c-Kit ligand. | 27059145 |
| Lymphoma | Stem Cell Exhaustion | Efficient Stem Cell Collection after Modified Cisplatin-Based Mobilization Chemotherapy in Patients with Diffuse Large B Cell Lymphoma. | 27060439 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | We retrospectively analyzed clinical characteristics, PBSC collection and autologous stem cell transplantation parameters, and hematologic reconstitution data for 65 patients with relapsed or refractory DLBCL who underwent PBSC collection after mobilization with the modified R-DHAP protocol at our institution between 2002 and 2013. | 27060439 |
| B-Cell Lymphomas, Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | In patients with relapsed or refractory diffuse large B cell lymphoma (DLBCL), R-DHAP (rituximab, dexamethasone, cytarabine, and cisplatin) is a commonly used regimen for salvage therapy and for mobilization of peripheral blood stem cells (PBSCs). | 27060439 |
| Acute leukemia | Stem Cell Exhaustion | Factors affecting survival in acute leukemia with donor lymphocyte infusion in the first relapse after allogeneic stem cell transplantation. | 27061552 |
| leukemia | Stem Cell Exhaustion | Relapse of leukemia relapsing after allogeneic (allo) stem cell transplantation (SCT) remains an important problem. | 27061552 |
| Viremia | Stem Cell Exhaustion | After stem cell transplant (SCT), 48% of patients developed at least 1 episode of viremia. | 27061703 |
| Cytomegalovirus Infections, Southern Sotho language, Viremia | Stem Cell Exhaustion | In contrast with SOT patients, where 58/74 (78%) D+R- patients had viremia, a low risk of CMV infection was seen after stem cell transplantation (1/27; 3.7%). | 27061703 |
| Specialty Type - cancer, Malignant tumor of colon, Neoplasms, Carcinogenesis | Stem Cell Exhaustion | Multiple stages of carcinogenesis in colon cancer encompass subpopulations of cancer stem cells (CSC), responsible for tumor cell transformation, growth and proliferation. | 27062566 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | The results indicate that the tumorigenesis of MDS is likely to originate at the stem cell level, suggesting that the WT1 mRNA level measurement in the BM is an effective prognostic marker in patients with MDS. | 27062571 |
| Arteriovenous fistula | Stem Cell Exhaustion | The association of endothelial progenitor cell markers with arteriovenous fistula maturation in hemodialysis patients. | 27068816 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Evaluations of efficacy of treatment modality in analyses on patients with acute myeloid leukemia (AML) often combine chemotherapy and stem cell transplantation (SCT). | 27069151 |
| Secondary malignant neoplasm of liver, Portal vein structure | Stem Cell Exhaustion | Predictive Value of Growth Factors and Interleukins for Future Liver Remnant Volume and Colorectal Liver Metastasis Volume Growth Following Portal Vein Embolization and Autologous Stem Cell Application. | 27069178 |
| Inflammation Mediators, Specialty Type - cancer | Stem Cell Exhaustion | Our results suggest that BE columnar epithelial cells with CD133 expression in apical surface undergo inflammation-mediated DNA damage, and mutated cells acquire the property of cancer stem cells with cytoplasmic CD133 expression. | 27069317 |
| Inflammation, Tissue damage | Stem Cell Exhaustion | Chronic inflammation and following tissue damage may activate progenitor cells under reactive oxygen/nitrogen species-rich environment. | 27069317 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | In Vitro Effects of Adipose-Derived Stem Cells on Breast Cancer Cells Harvested From the Same Patient. | 27070671 |
| Chronic skin ulcer | Stem Cell Exhaustion | Adipose-derived Stem Cells Added to Platelet-rich Plasma for Chronic Skin Ulcer Therapy. | 27071140 |
| Liver carcinoma | Stem Cell Exhaustion | Large intergenic non-coding RNA ribonucleic acids-ROR (lincRNA-ROR) has been reported to exert impacts on the maintenance of induced pluripotent stem cells and embryonic stem cells, and play important roles in human hepatocellular cancer. | 27071407 |
| Lymphoma | Stem Cell Exhaustion | Outcomes of MYC-associated lymphomas after R-CHOP with and without consolidative autologous stem cell transplant: subset analysis of randomized trial intergroup SWOG S9704. | 27072903 |
| Lymphoma | Stem Cell Exhaustion | Double hit lymphoma (DHL) and double protein-expressing (MYC, BCL2) lymphomas (DPL) fare poorly with R-CHOP (rituximab + cyclophosphamide, doxorubicin, vincristine, prednisolone); consolidative autologous stem cell transplant (ASCT) may improve outcomes. | 27072903 |
| Hypercholesterolemia | Stem Cell Exhaustion | We demonstrated in experimental studies that hypercholesterolaemia enhances the proliferation of haematopoietic stem cells and the subsequent differentiation to neutrophils, whereas HDL-cholesterol inhibits these processes. | 27073920 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Persisting AML blasts became more phenotypically distinct from stem and progenitor cells due to expression of novel marker patterns that differed from pre-treatment AML cells and from all cell types observed in healthy bone marrow. | 27074138 |
| Secondary Neoplasm, Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Cancer stem cells (CSCs) have gained much attention due to their roles in the invasion and metastasis of numerous kinds of human cancers. | 27074560 |
| Hematological Disease | Stem Cell Exhaustion | Cord blood (CB) has been an alternative stem cell source for patients with a wide variety of hematological diseases. | 27076239 |
| Graft acceptance | Stem Cell Exhaustion | Although higher rates of engraftment failure as compared to other stem cell sources after cord blood transplantation (CBT) have been a serious concern, the mechanisms underlying these failures have gradually been clarified by analyzing accumulated clinical data, thereby contributing to improvement of engraftment. | 27076239 |
| Specialty Type - cancer | Stem Cell Exhaustion | Enrichment of Cells with Cancer Stem Cell-Like Markers in Relapses of Chemoresistant Patients with Locally Advanced Head and Neck Squamous Cell Carcinoma. | 27077749 |
| Tissue Engineering | Stem Cell Exhaustion | In Vivo Functional Evaluation of Tissue-Engineered Vascular Grafts Fabricated Using Human Adipose-Derived Stem Cells from High Cardiovascular Risk Populations. | 27079751 |
| Huntingtons Disease Pathway | Stem Cell Exhaustion | Manifestation of Huntington's disease pathology in human induced pluripotent stem cell-derived neurons. | 27080129 |
| Adult Glioblastoma, Specialty Type - cancer | Stem Cell Exhaustion | Moreover, NUAK2 regulated cancer stem cell (CSC)-related gene expression in the glioblastoma cells. | 27081712 |
| leukemia | Stem Cell Exhaustion | Leukemia stem cells are in a hypoxic condition, which induces the expression of HIF-1a. | 27082496 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | Hematopoietic stem cell transplantation for pediatric mature B-cell acute lymphoblastic leukemia with non-L3 morphology and MLL-AF9 gene fusion: three case reports and review of the literature. | 27084248 |
| Infancy, Leukocytosis, BCR gene | Stem Cell Exhaustion | All patients achieved complete remission after conventional chemotherapy and subsequently underwent hematopoietic stem cell transplantation as high-risk ALL; patient 3 for infantile ALL with MLL rearrangement and the others for ALL with MLL rearrangement and hyperleukocytosis (white blood cell count at diagnosis >50 x 10(9)/L). | 27084248 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | To evaluate the efficacy and feasibility of upfront high-dose chemotherapy (HDCT) and rituximab (R) followed by autologous peripheral blood stem cell transplantation (auto-PBSCT) in patients with newly diagnosed high-intermediate(HI)-, and high(H)-risk diffuse large B-cell lymphoma (DLBCL), we conducted a multicenter prospective phase II trial. | 27084252 |
| Toxic effect, Infertility | Stem Cell Exhaustion | Conditioning regimens that include cyclophosphamide (CY) and total body irradiation (TBI) induce severe gonadal toxicity and permanent infertility in approximately 90 % of female patients who undergo hematopoietic stem cell transplantation (HSCT). | 27084256 |
| Multiple Myeloma | Stem Cell Exhaustion | A phase II, single-arm, prospective study of bendamustine plus melphalan conditioning for second autologous stem cell transplantation in de novo multiple myeloma patients through a tandem transplant strategy. | 27088375 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | This phase II trial evaluates, for the first time, the safety and efficacy of bendamustine plus high-dose melphalan (HDM) as a conditioning regimen before the second autologous stem cell transplantation (ASCT) in previously untreated multiple myeloma (MM) patients. | 27088375 |
| Primary Myelofibrosis | Stem Cell Exhaustion | Incidence and risk factors of poor graft function after allogeneic stem cell transplantation for myelofibrosis. | 27088376 |
| Primary Myelofibrosis | Stem Cell Exhaustion | Allogeneic hematopoieteic stem cell transplantation (HSCT) is the only curative treatment for myelofibrosis (MF), but it is still associated with significant risks and complications. | 27088376 |
| Hematologic Neoplasms, Mycoses | Stem Cell Exhaustion | Association of mannose-binding lectin levels and invasive fungal disease in hematologic malignancy patients receiving myelosuppressive chemotherapy or allogeneic hematopoietic stem cell transplantation. | 27088382 |
| Hematologic Neoplasms, Intrinsic Factor Deficiency, Mannose-Binding Protein Deficiency, Mycoses | Stem Cell Exhaustion | In this study, we investigated the association between MBL deficiency and invasive fungal disease (IFD) in hematologic malignancy patients receiving myelosuppressive chemotherapy or hematopoietic stem cell transplant. | 27088382 |
| Cardiotoxicity, Childhood Breast Carcinoma | Stem Cell Exhaustion | Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity. | 27089514 |
| Acute leukemia | Stem Cell Exhaustion | Impact of Donor Epstein-Barr Virus Serostatus on the Incidence of Graft-Versus-Host Disease in Patients With Acute Leukemia After Hematopoietic Stem-Cell Transplantation: A Study From the Acute Leukemia and Infectious Diseases Working Parties of the European Society for Blood and Marrow Transplantation. | 27091716 |
| B-Cell Lymphomas | Stem Cell Exhaustion | We describe the rationale and design of the ongoing randomized, active-controlled, multicenter, Phase III study evaluating the efficacy of pixantrone and rituximab versus gemcitabine and rituximab in patients with diffuse large B-cell lymphoma or follicular grade 3 lymphoma, who are ineligible for high-dose chemotherapy and stem cell transplantation, and who failed front-line regimens containing rituximab. | 27093976 |
| Malignant Peripheral Nerve Sheath Tumor, Myeloproliferative disease | Stem Cell Exhaustion | Myeloproliferative neoplasms (MPNs) share common clonal stem cells but show significant differences in their clinical courses. | 27094255 |
| Eosinophil count raised (finding) | Stem Cell Exhaustion | Retrospective Study of Incidence and Prognostic Significance of Eosinophilia after Allogeneic Hematopoietic Stem Cell Transplantation: Influence of Corticosteroid Therapy. | 27094383 |
| Eosinophil count raised (finding) | Stem Cell Exhaustion | The clinical significance of eosinophilia after allogeneic hematopoietic stem cell transplantation is controversial. | 27094383 |
| Eosinophil count raised (finding) | Stem Cell Exhaustion | This study aimed to retrospectively study the impact of eosinophilia on the outcome of allogeneic hematopoietic stem cell transplantation by taking into account the influence of corticosteroid therapy. | 27094383 |
| Acute lymphocytic leukemia, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | We retrospectively studied 204 patients with acute myeloid leukemia, acute lymphoblastic leukemia, and myelodysplastic syndrome who underwent allogeneic hematopoietic stem cell transplantation from January 2001 to December 2010. | 27094383 |
| Eosinophil count raised (finding) | Stem Cell Exhaustion | These results suggest that the clinical significance of eosinophilia in patients receiving allogeneic hematopoietic stem cell transplantation should be assessed with consideration of systemic corticosteroid administration. | 27094383 |
| Burkitt Lymphoma | Stem Cell Exhaustion | Many studies reported an improved prognosis in patients with Burkitt's lymphoma obviating the need of stem cell transplantation. | 27094615 |
| Acute lymphocytic leukemia, BCR gene | Stem Cell Exhaustion | The aim of this study is to compare the prognoses of BCL patients with similarly treated and nontransplanted patients with other types of acute lymphoblastic leukemia (ALL) and with ALL patients that underwent allogeneic stem cell transplantation (ASCT) in their first remissions. | 27094615 |
| Neutropenia, Acquired Immunodeficiency Syndrome | Stem Cell Exhaustion | Clinical uses of G-CSF includes mobilization of peripheral blood progenitor cells from healthy donors before hematopoietic stem cell transplantation, acceleration of neutrophil recovery following chemotherapy, and in the management of neutropenia due to other causes including AIDS and genetic disorders of granulocyte production. | 27094941 |
| Stem Cell Factor | Stem Cell Exhaustion | We analyzed lymph nodes from 22 patients with CHL, of which eight were of the NSCHL and 14 of the non-NSCHL subtype, using immunohistochemical staining of forkhead box P3 (FOXP3), transforming growth factor (TGF)-b, interleukin (IL)-3, IL-13, and stem cell factor (SCF). | 27095287 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | High-dose chemotherapy and autologous stem cell transplant compared with conventional chemotherapy for consolidation in newly diagnosed primary CNS lymphoma--a randomized phase III trial (MATRix). | 27098429 |
| X-linked inheritance, Combined immunodeficiency | Stem Cell Exhaustion | Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiency. | 27099176 |
| Immune System Diseases | Stem Cell Exhaustion | We used a lentiviral gene therapy approach to treat five SCID-X1 patients with persistent immune dysfunction despite haploidentical hematopoietic stem cell (HSC) transplant in infancy. | 27099176 |
| Relapsing course, Central neuroblastoma | Stem Cell Exhaustion | Remission With Donor Lymphocyte Infusion in a Child With Marrow Relapse After Haploidentical Stem Cell Transplantation for Relapsed Stage 4 Neuroblastoma. | 27100283 |
| Disseminated neuroblastoma, Bone Marrow Diseases | Stem Cell Exhaustion | A 7-year-old male with Stage 4 neuroblastoma was treated with chemotherapy and autologous hematopoietic stem cell transplantation (HSCT), resulting in partial response with residual bone and marrow disease. | 27100283 |
| neurological disability | Stem Cell Exhaustion | The patient received lenalidomide-based chemotherapy and consolidated by autologous stem cell transplantation for his POEMS syndrome, which improved the neurological disability. | 27100445 |
| Myeloid-Lymphoid Leukemia Protein | Stem Cell Exhaustion | Maintenance of hematopoietic stem cells and their potential to give rise to progenitors of differentiated lymphoid and myeloid cells are accomplished by a network of regulatory processes. | 27100840 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | GABP is necessary for stem/progenitor cell maintenance and myeloid differentiation in human hematopoiesis and chronic myeloid leukemia. | 27100840 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Moreover, drastically reduced clonogenic capacity of leukemic stem/progenitor cells isolated from bone marrow aspirates of chronic myeloid leukemia (CML) patients underlines the importance of GABP on stem/progenitor cell maintenance and confirms the relevance of GABP for human myelopoiesis in healthy and diseased states. | 27100840 |
| Myeloid | Stem Cell Exhaustion | Ectopic overexpression of a dominant-negative acting GABP mutant led to impaired myeloid differentiation of CD34(+) hematopoietic stem/progenitor cells obtained from healthy donors. | 27100840 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Correlations were identified between these genes, their expression patterns, and several classical clinical and pathologic parameters, molecular subtypes, and patient outcomes, as well as with proliferation, epithelial-mesenchymal transition, and breast cancer stem cell markers. | 27102007 |
| methyldopa, Glaucoma, CTCAE, Retinitis Pigmentosa | Stem Cell Exhaustion | The eye also has many potential target diseases amenable to stem cell-based treatment, such as corneal limbal stem cell deficiency, glaucoma, age-related macular degeneration (AMD), and retinitis pigmentosa (RP). | 27102165 |
| Disease | Stem Cell Exhaustion | The recent Zhongshan Ophthalmic Center Ocular Stem Cell Symposium discussed the potential applications of various stem cell types in stem cell-based therapies, drug discoveries and tissue engineering for treating ocular diseases. | 27102165 |
| Disease, Degenerative disorder | Stem Cell Exhaustion | Stem cells hold promise for treating a wide variety of diseases, including degenerative disorders of the eye. | 27102165 |
| Stargardts disease | Stem Cell Exhaustion | Recent results on the clinical trial of retinal pigment epithelial (RPE) cells from human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) in treating dry AMD and Stargardt's disease in the US, Japan, England, and China have generated great excitement and hope. | 27102165 |
| Failure, Acute GVH disease | Stem Cell Exhaustion | Both high and low levels of cellular Epstein-Barr virus DNA in blood identify failure after hematologic stem cell transplantation in conjunction with acute GVHD and type of conditioning. | 27102298 |
| Cessation of life, Specialty Type - cancer | Stem Cell Exhaustion | Heterogeneity within each PPCL persisted in culture for the frequency of cells expressing the cancer stem cell markers CD44, CD133, and c-Met and the immunologic markers human leukocyte antigen class II and programmed death ligand 1. | 27102771 |
| Bacteremia | Stem Cell Exhaustion | Characteristics comparisons of bacteremia in allogeneic and autologous hematopoietic stem cell-transplant recipients with levofloxacin prophylaxis and influence on resistant bacteria emergence. | 27103500 |
| Bacteremia | Stem Cell Exhaustion | The aim of this study was to compare the risk factors and clinical outcomes of bacteremia in allogeneic and autologous hematopoietic stem cell transplant (allo-HSCT and auto-HSCT) recipients with levofloxacin prophylaxis during the early period after transplantation. | 27103500 |
| Graft-vs-Host Disease, Lymphoma | Stem Cell Exhaustion | Donor T-cell immune responses can eradicate lymphomas after allogeneic hematopoietic stem cell transplantation (AHSCT), but can also damage healthy tissues resulting in harmful graft-versus-host disease (GVHD). | 27103745 |
| Neoplasms, Childhood Breast Carcinoma | Stem Cell Exhaustion | Furthermore, inhibition of expression of miR-200c or miR-141 overcomes tumor suppressive effects of PTC-209 including induction of cellular senescence and downregulation of breast cancer stem cell phenotype. | 27105531 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Tumor initiating cells (TICs), responsible for tumor initiation, and cancer stem cells (CSCs), responsible for tumor expansion and propagation, are often resistant to chemotherapeutic agents. | 27105533 |
| Sarcoma - category (morphologic abnormality), Liposarcoma, Myxoid, Giant cell sarcoma | Stem Cell Exhaustion | To find therapeutic targets against sarcoma initiating and propagating cells we used models of myxoid liposarcoma (MLS) and undifferentiated pleomorphic sarcoma (UPS) developed from human mesenchymal stromal/stem cells (hMSCs), which constitute the most likely cell-of-origin for sarcoma. | 27105533 |
| Cessation of life, Traumatic | Stem Cell Exhaustion | Human Traumatic Brain Injury Results in Oligodendrocyte Death and Increases the Number of Oligodendrocyte Progenitor Cells. | 27105664 |
| Neoplasms | Stem Cell Exhaustion | Here, we identified the cytokine receptor OSMR as a direct target gene of the transcription factor STAT3 in mouse astrocytes and human brain tumor stem cells (BTSCs). | 27110918 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Allogeneic stem cell transplantation for patients with mantle cell lymphoma who failed autologous stem cell transplantation: a national survey of the SFGM-TC. | 27111043 |
| Medial collateral ligament, Mantle cell lymphoma | Stem Cell Exhaustion | Poly-chemotherapy plus rituximab followed by autologous stem cell transplantation (auto-SCT) is standard care for untreated young patients with mantle cell lymphoma (MCL). | 27111043 |
| Nephroblastoma, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | This non-randomized single-center study evaluated medical costs and survival for acute myeloid leukemia between 2005 and 2010 in 50 patients: patients treated with induction and consolidation chemotherapy (ICT) alone; patients treated with ICT plus allogeneic hematopoietic stem cell transplantation (HCT), which is the current preferred post-remission therapy in patients with intermediate- and poor-risk AML with few co-morbidities, and patients treated with ICT plus immunotherapy using autologous dendritic cells (DC) engineered to express the Wilms' tumor protein (WT1). | 27111858 |
| methyldopa | Stem Cell Exhaustion | Replacement of diseased RPE with healthy, stem cell-derived RPE is a potential therapeutic strategy for treating AMD. | 27112176 |
| Multiple Myeloma | Stem Cell Exhaustion | Rationale and design of the German-Speaking Myeloma Multicenter Group (GMMG) trial ReLApsE: a randomized, open, multicenter phase III trial of lenalidomide/dexamethasone versus lenalidomide/dexamethasone plus subsequent autologous stem cell transplantation and lenalidomide maintenance in patients with relapsed multiple myeloma. | 27114074 |
| Primary Myelofibrosis | Stem Cell Exhaustion | A thrombopoietin receptor antagonist is capable of depleting myelofibrosis hematopoietic stem and progenitor cells. | 27114459 |
| leukemia | Stem Cell Exhaustion | Bortezomib, Doxorubicin, Cyclophosphamide, Dexamethasone Induction Followed by Stem Cell Transplantation for Primary Plasma Cell Leukemia: A Prospective Phase II Study of the Intergroupe Francophone du Myelome. | 27114594 |
| Clinical Observations Supplemental Qualifiers Dataset | Stem Cell Exhaustion | We conducted a prospective phase II trial in patients with pPCL to assess the efficacy of an alternate regimen that combines standard chemotherapy, a proteasome inhibitor, and high-dose melphalan and autologous stem cell transplantation (HDM/ASCT) followed by either allogeneic transplantation or bortezomib/lenalidomide maintenance. | 27114594 |
| Retinal Degeneration | Stem Cell Exhaustion | Retinal Structure Measurements as Inclusion Criteria for Stem Cell-Based Therapies of Retinal Degenerations. | 27116670 |
| Retinal Diseases | Stem Cell Exhaustion | Treatment Paradigms for Retinal and Macular Diseases Using 3-D Retina Cultures Derived From Human Reporter Pluripotent Stem Cell Lines. | 27116668 |
| Macular degeneration | Stem Cell Exhaustion | We discuss the use of pluripotent stem cell lines carrying fluorescent reporters driven by retinal promoters to derive three-dimensional (3-D) retina in culture and how this system can be exploited for elucidating human retinal biology, creating disease models in a dish, and designing targeted drug screens for retinal and macular degeneration. | 27116668 |
| Neoplasms, Malignant Neoplasms | Stem Cell Exhaustion | All MM cases from 2008 to 2013 were analyzed across 4 risk groups: stem cell transplantation (SCT), hematologic malignancy, solid tumors, and others. | 27117516 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | We describe the use and outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for multiple myeloma (MM) in Europe between January 1990 and December 2012. | 27118410 |
| Lymphoma, Non-Hodgkin, Familial, B-Cell Lymphomas | Stem Cell Exhaustion | Myeloablative autologous hematopoietic stem cell transplantation (HSCT) is a mainstay of therapy for relapsed intermediate-grade B-cell non-Hodgkin lymphoma (NHL); however, relapse rates are high. | 27118452 |
| Stable chronic Graft vs Host Disease, Osteoporosis | Stem Cell Exhaustion | We hypothesized that the prevalence of osteoporosis is high in a cohort of 258 patients with moderate to severe cGVHD because of prolonged exposure to risk factors for osteoporosis after allogeneic hematopoietic stem cell transplantation. | 27118572 |
| Stable chronic Graft vs Host Disease, Osteoporosis | Stem Cell Exhaustion | The association of higher platelet count in patients with cGVHD and osteoporosis has not been reported previously and represents a new area of interest in the study of osteoporosis after allogeneic hematopoietic stem cell transplantation. | 27118572 |
| Lymphoma | Stem Cell Exhaustion | Background This study examined employment patterns and associated factors in lymphoma survivors treated with high-dose chemotherapy with autologous stem cell transplantation (HDT-ASCT) from diagnosis to a follow-up survey at a mean of 10 years after HDT-ASCT. | 27123741 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Effectivity of a strategy in elderly AML patients to reach allogeneic stem cell transplantation using intensive chemotherapy: Long-term survival is dependent on complete remission after first induction therapy. | 27123833 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Intensive chemotherapy followed by allogeneic stem cell transplantation (alloSCT) can cure AML. | 27123833 |
| Cervical Intraepithelial Neoplasia, Granulocyte differentiation, Adult chronic idiopathic neutropenia, Acquired disorder | Stem Cell Exhaustion | Chronic idiopathic neutropenia (CIN) is an acquired disorder of granulopoiesis characterized by increased apoptosis of the bone marrow (BM) granulocytic progenitor cells under the influence of pro-inflammatory mediators and oligoclonal/monoclonal T-lymphocytes. | 27124520 |
| Osteosarcoma | Stem Cell Exhaustion | These stem cells and committed osteoblast precursors are the cell of origin in osteosarcoma, and RB1 gene mutations have a strong role in its pathogenesis. | 27124644 |
| Muscular Dystrophy, Duchenne | Stem Cell Exhaustion | Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Duchenne Muscular Dystrophy: Safety and Feasibility Study in India. | 27125141 |
| Muscular Dystrophy, Duchenne | Stem Cell Exhaustion | Given the regenerative and anti-inflammatory properties of mesenchymal stem cells (MSCs), here we investigated its role in the cellular therapy of DMD patients. | 27125141 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | These 65 had another 4 SNPs associated with gastric cancer susceptibility: PSCA (prostate stem cell antigen) rs2294008, PLCE1 (phospholipase C epsilon 1) rs2274223, PTGER4/PRKAA1 (prostaglandin E receptor 4/ protein kinase AMP-activated catalytic subunit alpha 1) rs13361707, and TYMS (thymidylate synthetase) rs2790. | 27127881 |
| Aortic Valve Stenosis | Stem Cell Exhaustion | Dysregulation of ossification-related miRNAs in circulating osteogenic progenitor cells obtained from patients with aortic stenosis. | 27129184 |
| Congenital bilateral aplasia of vas deferens | Stem Cell Exhaustion | The present study aimed to determine whether expression of ossification-related miRNAs is related to differentiation intro COPCs (circulating osteogenic progenitor cells) in patients with CAVD. | 27129184 |
| Dysgeusia | Stem Cell Exhaustion | Evaluation of the risk factors associated with high-dose chemotherapy-induced dysgeusia in patients undergoing autologous hematopoietic stem cell transplantation: possible usefulness of cryotherapy in dysgeusia prevention. | 27129837 |
| Dysgeusia | Stem Cell Exhaustion | The aim of this study was to retrospectively identify the risk factors related with dysgeusia in patients undergoing autologous hematopoietic stem cell transplantation (AHSCT). | 27129837 |
| Haiti | Stem Cell Exhaustion | For these reasons, RIT consolidation after chemoimmunotherapy induction has been our standard treatment approach at the University of Rochester for patients with HT who were ineligible for autologous stem cell transplantation. | 27130328 |
| Malignant neoplasm of lung | Stem Cell Exhaustion | Polymorphisms of the Stem Cell Marker Gene CD133 and the Risk of Lung Cancer in Chinese Population. | 27130457 |
| Tendon Injuries | Stem Cell Exhaustion | Tendon-derived stem cells (TDSCs) are a type of stem cells which may be used in the treatment of tendon injuries. | 27130678 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cells (CSC) have been observed and isolated from different solid tumours based on the expression of stem cell markers. | 27131799 |
| Aggressive behavior | Stem Cell Exhaustion | The stem cell markers CD44, Bmi1, Oct4 and Nanog are frequently expressed in MEC in relation to normal salivary gland and Oct4 and Nanog expression may contribute to aggressiveness and worst prognosis in MEC patients. | 27131799 |
| Perineural spread, Mucoepidermoid carcinoma of salivary gland | Stem Cell Exhaustion | Embryonic stem cells markers Oct4 and Nanog correlate with perineural invasion in human salivary gland mucoepidermoid carcinoma. | 27131799 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | In this trial, we addressed the tolerability and efficacy of adding rituximab with or without thiotepa to methotrexate-cytarabine combination therapy (the MATRix regimen), followed by a second randomisation comparing consolidation with whole-brain radiotherapy or autologous stem cell transplantation in patients with primary CNS lymphoma. | 27132696 |
| Whole brain radiation therapy | Stem Cell Exhaustion | Patients with responsive or stable disease after the first stage were then randomly allocated between whole-brain radiotherapy and autologous stem cell transplantation. | 27132696 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | The variant isoforms of CD44 (CD44v), which has been associated with treatment resistance and tumor recurrence, are contributed to the feature of some of the new cell surface markers for cancer stem cells. | 27133224 |
| Cachexia, Muscular Atrophy | Stem Cell Exhaustion | By using transcriptomics and cytokine profiling of human muscle stem cell-based models and human cancer-induced cachexia models in mice, we found that cachectic cancer cells secreted many inflammatory factors that rapidly led to high levels of fatty acid metabolism and to the activation of a p38 stress-response signature in skeletal muscles, before manifestation of cachectic muscle atrophy occurred. | 27135739 |
| Neoplasms | Stem Cell Exhaustion | Tumor stem cells have been found in a variety of neoplasms and stated to have a role in tumor progression. | 27136105 |
| Procedures on Peripheral Nervous System, Globoid cell leukodystrophy | Stem Cell Exhaustion | Evaluation of Krabbe disease burden and eligibility for hematopoietic stem cell transplantation are often based on neuroimaging findings using the modified Loes scoring system, which encompasses central but not peripheral nervous system changes. | 27137647 |
| VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | Stem Cell Exhaustion | This study aims to investigate the expression of CK15 and CK19 as possible stem cell markers in vitiligo during phototherapy. | 27139521 |
| VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | Stem Cell Exhaustion | This expression of cytokeratins was significantly correlated to improvement and can be considered valuable tool to monitor stem cells stimulation for the sake of the repigmentation process in vitiligo. | 27139521 |
| Neoplasms | Stem Cell Exhaustion | Ganglioneuromas are rare, benign neoplasms derived from sympathetic neural crest progenitor cells. | 27140023 |
| Amyloidosis | Stem Cell Exhaustion | Stem cell transplantation compared with melphalan plus dexamethasone in the treatment of immunoglobulin light-chain amyloidosis. | 27142462 |
| Primary amyloidosis | Stem Cell Exhaustion | Autologous stem cell transplantation (SCT) is a common management strategy for select patients with immunoglobulin light-chain amyloidosis, but no trials have documented improved overall survival. | 27142462 |
| Encephalomyelitis, Acute Disseminated, Neurologic Symptoms | Stem Cell Exhaustion | Seven years after disease onset, the patient developed severe neurological symptoms resembling acute disseminated encephalomyelitis, prompting allogeneic hematopoietic stem cell transplantation (HSCT) with the HLA-identical mother as donor. | 27146671 |
| Malignant Neoplasms | Stem Cell Exhaustion | Children were eligible if they were <22 years old and had a high-risk malignancy, recurrence, or required hematopoietic stem cell transplantation (HSCT). | 27148856 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | The clonally expansion of an abnormal pluripotent hematopoetic stem cell could be responsible for both, PV and DLBCL. | 27151728 |
| Embryonic Mosaic | Stem Cell Exhaustion | Personalized Stem Cell Therapy to Correct Corneal Defects Due to a Unique Homozygous-Heterozygous Mosaicism of Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome. | 27151912 |
| ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 1 | Stem Cell Exhaustion | This study supports the rationale for the development of cultured autologous oral mucosal epithelial stem cell sheets obtained by selected heterozygous R311K-p63 stem cells, as an effective and personalized therapy for reconstructing the ocular surface of this unique case of EEC syndrome, thus bypassing gene therapy approaches. | 27151912 |
| Corneal degeneration | Stem Cell Exhaustion | No definitive treatments are available to counteract and resolve the progressive corneal degeneration due to a premature aging of limbal epithelial stem cells. | 27151912 |
| Somatic mosaicism | Stem Cell Exhaustion | A detailed analysis of the degree of somatic mosaicism in leukocytes from peripheral blood and oral mucosal epithelial stem cells (OMESCs) from biopsies of buccal mucosa showed that approximately 80% were homozygous mutant cells and 20% were heterozygous. | 27151912 |
| Rudiger syndrome 1 | Stem Cell Exhaustion | The heterozygous mutant R311K-p63 stem cells can be isolated by means of clonal analysis and given their good regenerative capacity, they may be used to successfully correct the corneal defects present in this unique case of ectrodactyly-ectodermal dysplasia-clefting syndrome. | 27151912 |
| Congenital Heart Defects | Stem Cell Exhaustion | Stem cell therapy for children with congenital heart defects is moving forward, with several completed and ongoing clinical trials. | 27151913 |
| Heart failure | Stem Cell Exhaustion | Age-Dependent Effect of Pediatric Cardiac Progenitor Cells After Juvenile Heart Failure. | 27151913 |
| Heart failure | Stem Cell Exhaustion | Here we investigate the role of age of human pediatric cardiac progenitor cells (hCPCs) on ventricular remodeling in a model of juvenile heart failure. | 27151913 |
| Heart failure | Stem Cell Exhaustion | This study using human cardiac progenitor cells shows age-related changes in the reparative ability of cells in a model of pediatric heart failure and uses computational and systems biology to elucidate potential mechanisms. | 27151913 |
| Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease, Periodicity | Stem Cell Exhaustion | Two-hundred and sixty-nine females aged <=42 and undergoing an allogeneic stem cell transplant were retrospectively studied to assess the effect of age, conditioning regimen and chronic graft-versus-host disease (cGVHD) on resumption of stable menstrual cyclicity. | 27153290 |
| Skeletal muscle atrophy | Stem Cell Exhaustion | Expression of a klotho transgene in mdx mice restored their longevity, reduced muscle wasting, improved function and greatly increased the pool of muscle-resident stem cells required for regeneration. | 27154199 |
| Lung Injury | Stem Cell Exhaustion | Proteome Profiling in Lung Injury after Hematopoietic Stem Cell Transplantation. | 27155584 |
| Pulmonary Complication, Communicable Diseases, Lung Injury, Idiopathic pneumonia syndrome | Stem Cell Exhaustion | Pulmonary complications due to infection and idiopathic pneumonia syndrome (IPS), a noninfectious lung injury in hematopoietic stem cell transplant (HSCT) recipients, are frequent causes of transplantation-related mortality and morbidity. | 27155584 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | In seven patients, more than two (2-6) different therapies were registered; four were exposed to fludarabine-based therapy, three to radiotherapy and two to autologous stem-cell transplantation, and in the RIT cohort, two patients developed myelodysplastic syndrome. | 27157440 |
| Cryptococcus, Injury of kidney | Stem Cell Exhaustion | Disseminated cryptococcal infection in allogeneic stem cell transplant patients: a rare cause of acute kidney injury. | 27159179 |
| Hematological Disease | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (HSCT) can be lifesaving for some of the deadliest hematologic diseases. | 27159179 |
| Epithelial ovarian cancer, Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | To investigate the role of cancer stem cell marker CD44 variant 6 in the development of distant metastasis in patients with epithelial ovarian cancer. | 27159753 |
| Childhood Craniopharyngioma, Pituitary Adenoma | Stem Cell Exhaustion | Differential Expression of Stem Cell Markers in Human Adamantinomatous Craniopharyngioma and Pituitary Adenoma. | 27161333 |
| Pituitary Adenoma | Stem Cell Exhaustion | Our aim was to characterize the expression pattern of ABCG2, CD44, DLL4, NANOG, NOTCH2, POU5F1/OCT4, SOX2, and SOX9 stem cell markers in human ACP and pituitary adenoma. | 27161333 |
| Adenoma, Pituitary Neoplasms, American College of Physicians | Stem Cell Exhaustion | Our results confirm the presence of stem cell markers in human pituitary tumours as well as the different expression patterns of ACP and adenoma. | 27161333 |
| American College of Physicians | Stem Cell Exhaustion | Adamantinomatous CP (ACP) was associated with an activating mutation in b-catenin, and it has been postulated that pituitary stem cells might play a role in oncogenesis in human ACP. | 27161333 |
| Pituitary Adenoma | Stem Cell Exhaustion | Stem cells have also been identified in pituitary adenoma. | 27161333 |
| Liver carcinoma, Neoplasms | Stem Cell Exhaustion | Immunohistochemical study of hepatocyte, cholangiocyte and stem cell markers of hepatocellular carcinoma: the second report: relationship with tumor size and cell differentiation. | 27161394 |
| Liver carcinoma, HCCS gene, Neoplasms | Stem Cell Exhaustion | The purpose of this study is to investigate whether ordinary hepatocellular carcinomas (HCCs) show positivity of stem/progenitor cell markers and cholangiocyte markers during the process of tumor progression. | 27161394 |
| Hollings Cancer Center | Stem Cell Exhaustion | Ninety-four HCC lesions no larger than 8 cm from 94 patients were immuno-histochemically studied using two hepatocyte markers (Hep par 1 and a-fetoprotein), five cholangiocyte markers (cytokeratin CK7, CK19, Muc1, epithelial membrane antigen and carcinoembryonic antigen) and three hepatic stem/progenitor cell markers (CD56, c-Kit and EpCAM). | 27161394 |
| Neoplasms | Stem Cell Exhaustion | The positive ratios of stem/progenitor cell markers tended to be higher in larger sized and more poorly differentiated tumors (except for c-Kit). | 27161394 |
| Hollings Cancer Center, Neoplasms | Stem Cell Exhaustion | Ordinary HCC can acquire the characteristic of positivity of cholangiocyte and stem/progenitor cell markers during the process of tumor progression. | 27161394 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | High-dose melphalan 200 mg/m(2) (MEL 200) is the standard of care as a conditioning regimen for autologous hematopoietic stem cell transplantation (AHSCT) for multiple myeloma (MM). | 27164062 |
| Herpes Simplex Infections | Stem Cell Exhaustion | Complex management of resistant oral herpes simplex virus infection following hematopoietic stem cell transplantation: potential role of topical cidofovir. | 27165053 |
| Herpes Simplex Infections, Simplexvirus, Communicable Diseases | Stem Cell Exhaustion | Herpes simplex virus (HSV) infection commonly occurs during the immunosuppression associated with hematopoietic stem cell transplantation (HSCT). | 27165053 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Leukemic stem cell persistence in chronic myeloid leukemia patients in deep molecular response induced by tyrosine kinase inhibitors and the impact of therapy discontinuation. | 27167108 |
| Aplastic Anemia, Communicable Diseases | Stem Cell Exhaustion | [Successful treatment of an overwhelming infection with granulocyte transfusion in severe aplastic anemia patient undergoing allogeneic peripheral blood stem cell transplantation]. | 27169447 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | We tested the hypothesis that proliferative activity of hematopoietic stem cells has impact on survival in newly diagnosed patients with myelodysplastic syndrome (MDS) and secondary acute myeloid leukemia (AML). | 27170453 |
| Simian immunodeficiency virus | Stem Cell Exhaustion | Initiation of Antiretroviral Therapy Restores CD4+ T Memory Stem Cell Homeostasis in Simian Immunodeficiency Virus-Infected Macaques. | 27170752 |
| SLITRK1 wt Allele, Acupuncture and Oriental Medicine, Memory | Stem Cell Exhaustion | T memory stem cells (TSCM) are a unique memory T cell subset with enhanced self-renewal capacity and the ability to differentiate into other memory T cell subsets, such as central and transitional memory T cells (TCM and TTM, respectively). | 27170752 |
| Glioblastoma Multiforme Pathway, Neoplasms | Stem Cell Exhaustion | Glioma Cells in the Tumor Periphery Have a Stem Cell Phenotype. | 27171431 |
| Glioma, Neoplasms | Stem Cell Exhaustion | The results showed that tumor cells in the periphery of patient gliomas expressed stem cell markers, however for most markers at a significantly lower level than in the tumor core. | 27171431 |
| Glioma, Neoplasms | Stem Cell Exhaustion | In conclusion tumor cells in the periphery of patient gliomas have a stem cell phenotype, although it is less pronounced than in the tumor core. | 27171431 |
| Adult Glioblastoma | Stem Cell Exhaustion | Migrating cells in orthotopic glioblastoma xenografts preserve expression and stem cell markers. | 27171431 |
| Retinitis Pigmentosa | Stem Cell Exhaustion | A retrospective case report of a retinitis pigmentosa patient who underwent vitrectomy for epiretinal membrane after intravitreal autologous stem cell implantation. | 27171917 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | Phase 2 study of intensified chemotherapy and allogeneic hematopoietic stem cell transplantation for older patients with acute lymphoblastic leukemia. | 27171984 |
| Toxoplasmosis | Stem Cell Exhaustion | A matched case-control study of toxoplasmosis after allogeneic haematopoietic stem cell transplantation: still a devastating complication. | 27172809 |
| Toxoplasmosis | Stem Cell Exhaustion | Toxoplasmosis (TXP) is a life-threatening complication of allogeneic haematopoietic stem cell transplantation (AHSCT). | 27172809 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | The CXCL12/CXCR4 axis is involved in regulation of proliferation, survival and trafficking of hematopoietic stem cells, including B lymphocytes and disruption within this signaling pathway has been implicated in pathogenesis of chronic lymphocytic leukemia (CLL). | 27173875 |
| Acute GVH disease | Stem Cell Exhaustion | Administration of 81 mesenchymal stromal cell end-products to 26 patients with severe steroid-resistant acute graft-versus-host disease in 7 stem cell transplant centers who were refractory to many lines of treatment, induced a 77% overall response at the primary end point (day 28). | 27175026 |
| Chromosome Aberrations | Stem Cell Exhaustion | Autologous stem cell transplantation could improve, but not overcome the adverse prognostic effect of high-risk cytogenetic abnormalities. | 27175647 |
| Specialty Type - cancer | Stem Cell Exhaustion | The benchmarking of the experimental data with the clinical course highlights that patients with prevalence of circulating cancer stem cells (CD45(neg)CD133(pos)) have a lower overall survival. | 27176720 |
| leukemia | Stem Cell Exhaustion | ABCG2, Cytogenetics, and Age Predict Relapse after Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia in Complete Remission. | 27178373 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Few data are available in patients with AML undergoing allogeneic stem cell transplantation (SCT), particularly when in complete remission (CR). | 27178373 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | Significant morbidity and mortality was observed among hematopoietic stem cell transplant patients (7.3%, 60-day mortality), solid organ transplant patients (13.3%, 60-day mortality), and COPD patients (12.8%, 60-day mortality). | 27179369 |
| Secondary Neoplasm, Malignant Neoplasms | Stem Cell Exhaustion | Bmi-1 acts as an oncogene by controlling cell cycle and self-renewal of adult stem cells, and its overexpression correlates with metastasis and poor prognosis in several cancers. | 27180058 |
| Tumor necrosis | Stem Cell Exhaustion | Relative to OLHDF, HFR was associated with greater indoxyl sulfate removal and lesser abnormalities in all other study variables, namely circulating interleukin-6, tumor necrosis factor-alpha, proportions of activated proinflammatory (CD14+CD16+, CD14++CD16+) monocytes, endothelial progenitor cells, apoptotic endothelial microparticles, vascular endothelial growth factor, vascular cellular adhesion molecule, angiopoietins 2 and 1, annexin V, and superoxide dismutase. | 27182679 |
| Multiple Myeloma | Stem Cell Exhaustion | We evaluated the impact of RI on outcomes of patients with multiple myeloma treated with melphalan 200 mg/m2 (Mel200) and autologous stem cell transplantation. | 27183094 |
| Specialty Type - cancer, REG1CP gene, Multiple Myeloma | Stem Cell Exhaustion | We analysed relative survival (RS) of patients diagnosed in 1998-2011 and treated with ASCT within 12 months after diagnosis in Germany (n = 3591; German Registry of Stem Cell Transplantation) and compare RS with survival of myeloma patients diagnosed in the same years in Germany (n = 13,903; population-based German Cancer Registries). | 27185572 |
| Mucopolysaccharidosis II | Stem Cell Exhaustion | X-Chromosome Inactivation Analysis in Different Cell Types and Induced Pluripotent Stem Cells Elucidates the Disease Mechanism in a Rare Case of Mucopolysaccharidosis Type II in a Female. | 27187040 |
| Childhood Non-Hodgkin Lymphoma, Relapsing course | Stem Cell Exhaustion | Comparison of Total Body Irradiation (TBI) Conditioning with Non-TBI for Autologous Stem Cell Transplantation in Newly Diagnosed or Relapsed Mature T- and NK-Cell Non-Hodgkin Lymphoma. | 27188204 |
| Toxic effect, Lymphoma | Stem Cell Exhaustion | This retrospective study was conducted for comparison of survival outcomes and toxicities of autologous stem cell transplantation (ASCT) based on the use of total body irradiation (TBI) as a part of the conditioning regimen in patients with mature T- and natural killer (NK)-cell lymphomas. | 27188204 |
| Embryonic Mosaic, Hereditary Diffuse Leukoencephalopathy with Spheroids | Stem Cell Exhaustion | Our findings suggest that expression of wild-type CSF1R in some cells, whether achieved by mosaicism or chimerism, may confer benefit in hereditary diffuse leukoencephalopathy with axonal spheroids and suggest that haematopoietic stem cell transplantation might have a therapeutic role for this disorder. | 27190017 |
| Liver carcinoma | Stem Cell Exhaustion | De novo HAPLN1 expression hallmarks Wnt-induced stem cell and fibrogenic networks leading to aggressive human hepatocellular carcinomas. | 27191501 |
| Aggressive course | Stem Cell Exhaustion | Both networks were linked by Hyaluronan And Proteoglycan Link Protein 1 (HAPLN1), that appeared de novo in aggressive HCCs expressing cytoplasmic b-catenin and stem cell markers. | 27191501 |
| Liver carcinoma, HCCS gene, Hollings Cancer Center | Stem Cell Exhaustion | About 20% hepatocellular carcinomas (HCCs) display wild-type b-catenin, enhanced Wnt signaling, hepatocyte dedifferentiation and bad outcome, suggesting a specific impact of Wnt signals on HCC stem/progenitor cells. | 27191501 |
| Peripheral Blood Stem Cells, PAFAH1B1 wt Allele | Stem Cell Exhaustion | A 17-year-old patient was diagnosed with MDS and required initiation of peripheral blood stem cell transplantation within a maximum of 3 weeks and was in the luteal phase of the menstrual cycle when the possibility of attempting preservation of fertility was presented to her. | 27191608 |
| Necrosis, Adult Glioblastoma | Stem Cell Exhaustion | Transforming growth factor-b and stem cell markers are highly expressed around necrotic areas in glioblastoma. | 27193555 |
| Necrosis | Stem Cell Exhaustion | In addition, the stem cell markers CD133 and alkaline phosphatase (ALPL) were also highly expressed around necrotic foci in GBM tissues. | 27193555 |
| Hypoxia | Stem Cell Exhaustion | These results collectively support the hypothesis that tissue hypoxia induces the stem cell phenotype through TGF-b-related EMT and contributes to the poor outcome of GBM patients. | 27193555 |
| Degenerative polyarthritis | Stem Cell Exhaustion | We sought to establish the in-vivo immune response in collagenase-induced OA and investigate the ability of human mesenchymal stem cells (hMSCs) overexpressing viral interleukin 10 (vIL-10) to modulate immune populations and delay/prevent disease progression. | 27194025 |
| Carcinosarcoma, Carcinoma, Spindle-Cell | Stem Cell Exhaustion | We believe trichoblastic carcinosarcoma is an authentic carcinosarcoma derived from multiple progenitor cells whereas epidermal carcinosarcomas are derived from a single progenitor cell that undergoes epithelial to mesenchymal transition, and are better considered as sarcomatoid carcinomas. | 27194674 |
| Wasting, Antilymphocyte Serum | Stem Cell Exhaustion | Our results on Pax7 and MyoD protein expression suggest that proliferation and differentiation of skeletal muscle stem cells are affected in ALS patients, and the myogenic processes cannot overcome the denervation-induced wasting. | 27195289 |
| Specialty Type - cancer | Stem Cell Exhaustion | However, a recent study has been interpreted to suggest that random mutations during stem cell divisions are the major contributor to human cancer. | 27196525 |
| Vestibular Diseases | Stem Cell Exhaustion | Regenerative therapy for vestibular disorders using human induced pluripotent stem cells (iPSCs): neural differentiation of human iPSC-derived neural stem cells after in vitro transplantation into mouse vestibular epithelia. | 27196942 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Unrelated donors are associated with improved relapse-free survival compared to related donors in patients with myelodysplastic syndrome undergoing reduced intensity allogeneic stem cell transplantation. | 27197602 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Reduced intensity allogeneic stem cell transplantation (RI alloSCT) is a potentially curative treatment approach for patients with myelodysplastic syndrome (MDS). | 27197602 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Exercise-induced endothelial progenitor cell mobilization is attenuated in impaired glucose tolerance and type 2 diabetes. | 27197857 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Circulating endothelial progenitor cells (EPCs) contribute to vascular homeostasis and are fewer in those with type 2 diabetes mellitus (T2DM) compared with normal glucose tolerance (NGT), suggesting a link between EPCs and T2DM-associated vasculopathies. | 27197857 |
| Morular Metaplasia of the Endometrium, Malignant Neoplasms, Multiple Myeloma | Stem Cell Exhaustion | Aldehyde dehydrogenase (ALDH) is highly active in physiological stem cells as well as in tumor-initiating cells of some malignancies including multiple myeloma (MM). | 27199264 |
| Toxoplasmosis | Stem Cell Exhaustion | After a cluster of fatal toxoplasmosis among stem cell transplant recipients at 2 hospitals, surveillance with polymerase chain reaction (PCR) (blood) was instituted. | 27199460 |
| Lymphoma, Follicular, Lymphoma | Stem Cell Exhaustion | Prognostic impact of history of follicular lymphoma, induction regimen and stem cell transplant in patients with MYC/BCL2 double hit lymphoma. | 27203548 |
| Sepsis, Hematological Disease, Malignant Neoplasms | Stem Cell Exhaustion | The current quality improvement project embedded sepsis best practices into routine care for ambulatory clinic patients receiving chemotherapy or undergoing hematopoietic stem cell transplantation for hematologic disease or malignancies. | 27206294 |
| Scleromyxedema | Stem Cell Exhaustion | High-dose melphalan with autologous stem cell transplantation appears to be a safe and effective long-term treatment in patients with scleromyxedema. | 27207484 |
| physiopathological, Metabolic Diseases, Peripheral Arterial Diseases | Stem Cell Exhaustion | Plasma Levels of Proprotein Convertase Subtilisin/Kexin Type 9 Are Elevated in Patients With Peripheral Artery Disease and Associated With Metabolic Disorders and Dysfunction in Circulating Progenitor Cells. | 27207972 |
| Hepatobiliary System, Choledocholithiasis, Venoocclusive disease, Cholecystitis, Graft-vs-Host Disease, Cholangitis | Stem Cell Exhaustion | To determine whether gallbladder sonographic findings in hematopoietic stem cell (HSC) transplant patients can distinguish among hepatobiliary complications of HSC transplants (graft-versus-host disease [GVHD] and veno-occlusive disease) and biliary events (cholecystitis, cholangitis, and choledocholithiasis). | 27208200 |
| Rheumatoid Arthritis, Inflammation | Stem Cell Exhaustion | Arterial wall inflammation, bone marrow and splenic activity (index of progenitor cell activity) was assessed with (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) in RA patients in remission (disease activity score (DAS28) <2.6 for >6 months) and healthy controls. | 27209093 |
| Restenosis | Stem Cell Exhaustion | The Combo stent combines an abluminal biodegradable coating eluting sirolimus and a luminal anti-CD34(+) antibody layer to attract endothelial progenitor cells in order to promote vessel healing, thus preventing neointima formation and restenosis. | 27209254 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Outcomes for patients with multiple myeloma (MM) have improved in recent years owing to use of novel agents and high-dose therapy followed by autologous stem cell transplant (ASCT). | 27211270 |
| Weight decreased | Stem Cell Exhaustion | Weight Loss Upregulates the Small GTPase DIRAS3 in Human White Adipose Progenitor Cells, Which Negatively Regulates Adipogenesis and Activates Autophagy via Akt-mTOR Inhibition. | 27211557 |
| Clostridium difficile colitis | Stem Cell Exhaustion | Fecal microbiota transplantation for recurrent Clostridium difficile infection in hematopoietic stem cell transplant recipients. | 27214585 |
| Clostridium difficile colitis, Central Diabetes Insipidus, Intestinal dysbiosis | Stem Cell Exhaustion | Recurrent Clostridium difficile infection (CDI) is a consequence of intestinal dysbiosis and is particularly common following hematopoietic stem cell transplantation (HSCT). | 27214585 |
| Injury of kidney | Stem Cell Exhaustion | Effects of CYP3A5 polymorphism on the pharmacokinetics of a once-daily modified-release tacrolimus formulation and acute kidney injury in hematopoietic stem cell transplantation. | 27217047 |
| Osteoarthritis, Knee | Stem Cell Exhaustion | Although this phase I study included a limited number of patients without a placebo arm, it showed that local injection of autologous adipose-derived stem cells was safe and well tolerated in patients with knee osteoarthritis. | 27217345 |
| Degenerative disorder | Stem Cell Exhaustion | This information can be used in future studies to potentially enhance or predict responses to hNPC and other stem cell therapies for retinal degenerative diseases. | 27217715 |
| Unspecified visual loss | Stem Cell Exhaustion | Although treatment options for RDDs are limited, stem and progenitor cell-based therapies have great potential to halt or slow the progression of vision loss. | 27217715 |
| Retinal Degeneration | Stem Cell Exhaustion | Gene expression changes in the retina following subretinal injection of human neural progenitor cells into a rodent model for retinal degeneration. | 27217715 |
| Behavioral Symptoms Index Composite Score (BASC-2), Infection of bloodstream | Stem Cell Exhaustion | Bloodstream infections (BSI) are frequent and potentially severe complications in allogeneic hematopoietic stem cell transplant (AHSCT) recipients. | 27218243 |
| Pertussis, Specialty Type - cancer, Pneumonia | Stem Cell Exhaustion | We illustrate 2 cases of pneumonia associated with Bordetella pertussis infection in 72-year-old and 61-year-old patients with cancer receiving myelosuppressive therapy after hematopoietic stem cell transplantation. | 27218794 |
| Bacterial Infections, Specialty Type - cancer | Stem Cell Exhaustion | Bacterial infections are a significant cause of morbidity and mortality in patients with cancer, and those receiving hematopoietic stem cell transplant, solid organ transplant, or myelosuppressive therapy are at increased risk. | 27218794 |
| Toxic effect, Multiple Myeloma | Stem Cell Exhaustion | Effect of melphalan 140 mg/m(2) vs 200 mg/m(2) on toxicities and outcomes in multiple myeloma patients undergoing single autologous stem cell transplantation-a single center experience. | 27219740 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Although melphalan at a dose of 140 mg/m(2) (MEL140) is an acceptable conditioning regimen for autologous stem cell transplantation (ASCT) in multiple myeloma (MM) patients, very few studies compared it to the most commonly used dose of 200 mg/m(2) (MEL200). | 27219740 |
| Diabetic Foot | Stem Cell Exhaustion | Clinical Evaluation of Human Umbilical Cord Mesenchymal Stem Cell Transplantation After Angioplasty for Diabetic Foot. | 27219884 |
| Ulcer | Stem Cell Exhaustion | Aims: The multilineage differentiation potential of human umbilical cord mesenchymal stem cells (HUCMSCs) holds therapeutic promise for non-healing ulcers and tissue regeneration. | 27219884 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Because CCR4 is expressed on normal regulatory T cells as well as on ATLL cells, MOG may accelerate graft-versus-host disease (GVHD) by eradicating regulatory T cells in patients with allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 27220263 |
| Unknown (origin) (qualifier value), palladium | Stem Cell Exhaustion | Additionally, idiopathic PD but not LRRK2-associated PD patients showed increased levels of the pro-inflammatory marker interleukin-12-p40 as well as the anti-inflammatory species interleukin-10, brain-derived neurotrophic factor, and stem cell factor. | 27220776 |
| neurological complication | Stem Cell Exhaustion | Neurological complications (NC) after hematopoietic stem cell transplantation (HSCT) are rare events. | 27222935 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | Cytomegalovirus infection in autologous stem cell transplant recipients in the era of rituximab. | 27225264 |
| Malignant Neoplasms | Stem Cell Exhaustion | This clinical-grade platform provides the basis for a phase 1 trial evaluating the activity of CD19-CAR-modified CD8(+) TSCM in patients with B-cell malignancies refractory to prior allogeneic hematopoietic stem cell transplantation. | 27226436 |
| Neoplasms | Stem Cell Exhaustion | Long-lived, self-renewing, multipotent T memory stem cells (TSCM) can trigger profound and sustained tumor regression but their rareness poses a major hurdle to their clinical application. | 27226436 |
| Multiple Myeloma | Stem Cell Exhaustion | Although allogeneic stem cell transplantation is not a standard therapy for multiple myeloma, some patients can benefit from this intense therapy. | 27229716 |
| Primary Myelofibrosis | Stem Cell Exhaustion | Serial 18F-FDG PET for Monitoring Treatment Response After Allogeneic Stem Cell Transplantation for Myelofibrosis. | 27230931 |
| Primary Myelofibrosis | Stem Cell Exhaustion | Our objective was to assess the feasibility of 18F-FDG PET/CT for noninvasive monitoring of treatment response after allogeneic stem cell transplantation (SCT) for myelofibrosis. | 27230931 |
| melphalan/prednisone protocol | Stem Cell Exhaustion | Therefore, we studied effect of LVAD on three circulating vascular biomarkers: stem cells (SC), endothelial progenitor cells (EPC) and microparticles (MP). | 27232919 |
| Central neuroblastoma | Stem Cell Exhaustion | Individuals eligible for our cohort were aged <20 yr when diagnosed with high-risk neuroblastoma and received cancer-directed therapy including stem cell transplantation at Hospital de Ninos Sor Maria Ludovica between February 1999 and February 2015. | 27235336 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Autologous haematopoietic progenitor cell (HPC) transplantation is indicated to treat some haematological malignancies. | 27237104 |
| Pleural effusion disorder | Stem Cell Exhaustion | Incidence, etiology, and outcome of pleural effusions in allogeneic hematopoietic stem cell transplantation. | 27238902 |
| Pleural effusion disorder, Pleural Effusion, CTCAE | Stem Cell Exhaustion | Pleural effusion is a known entity in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT); however, the incidence, risk factors, and morbidity-mortality outcomes associated with pleural effusions remain unknown. | 27238902 |
| Acute GVH disease, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Increase of endothelial progenitor cells in acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia. | 27239737 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | 47 patients with acute myeloid leukaemia (AML) who were in complete remission as they underwent allogeneic hematopoietic stem cell transplantation with myeloablative conditioning with PBSC as stem cell source were enrolled in the study. | 27239737 |
| Graft-vs-Host Disease, Acute GVH disease, Endothelial dysfunction | Stem Cell Exhaustion | Circulating endothelial progenitor cells (EPCs; CD31+ CD34(bright)CD133+ CD45(dim) cells) are novel markers of endothelial dysfunction and related to inflammatory processes such as acute graft-versus-host disease (aGvHD). | 27239737 |
| leukemia | Stem Cell Exhaustion | Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) is considered the mainstay of the treatment for both subtypes of leukemia due to their refractoriness to chemotherapy and high rates of relapse, it remains unclear whether allo-HSCT is curative in such cases due to their scarcity. | 27244257 |
| Specialty Type - cancer | Stem Cell Exhaustion | The Distribution of Human Stem Cell-like Memory T Cell in Lung Cancer. | 27244531 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Autologous stem cell transplantation remains important in the treatment of myeloma and relapsed lymphoma. | 27245311 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | A total of 277 patients with myeloma and lymphoma had stem cell mobilization; 97.5% were successfully mobilized, including 41.5% who received plerixafor. | 27245311 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Rescue plerixafor was more effective in patients with myeloma than lymphoma as after 1 dose of plerixafor; 85% versus 55% collected a minimum number of stem cells (2 x 10E6 CD34 cells/kg) for 1 transplant and 51% versus 15% collected > 5 x 10E6 CD34 cells/kg. | 27245311 |
| Nerve Degeneration | Stem Cell Exhaustion | More recently, efforts have shifted to the development of a more accurate model to decipher the precise mechanisms of neurodegeneration, using induced pluripotent stem cells derived from SA SCA7 patients. | 27245542 |
| Multiple Sclerosis | Stem Cell Exhaustion | A cohort of patients with poor-prognosis multiple sclerosis (MS) underwent chemotherapy-based immune ablation followed by immune reconstitution with an autologous hematopoietic stem cell transplant (IA/aHSCT). | 27246142 |
| Cessation of life | Stem Cell Exhaustion | Late Mortality and Causes of Death among Long-Term Survivors after Allogeneic Stem Cell Transplantation. | 27246369 |
| Cessation of life | Stem Cell Exhaustion | We sought to assess the late mortality risks and causes of death among long-term survivors of allogeneic hematopoietic stem cell transplantation (HCT). | 27246369 |
| Observation of attack, Bone marrow hypocellularity | Stem Cell Exhaustion | These data suggest that HLA-LLs are a useful marker of the presence of immune pathophysiology in AA and that T-cell attacks against hematopoietic progenitor cells, rather than against hematopoietic stem cells, can trigger bone marrow failure in AA patients. | 27250585 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | The most ubiquitous, CD44 standard, has been used as a cancer stem cell marker in ovarian and other cancers. | 27253518 |
| Diabetes | Stem Cell Exhaustion | The mobilization of hematopoietic stem cells (HSCs) and EPCs in response to G-CSF is impaired by diabetes, owing to CXCL12 dysregulation. | 27255499 |
| Diabetes | Stem Cell Exhaustion | We re-analysed data gathered in the NCT02056210 trial, wherein patients with (n = 10) and without diabetes (n = 10) received plerixafor to test stem/progenitor cell mobilization. | 27255499 |
| Diabetes Mellitus | Stem Cell Exhaustion | Diabetes damages the endothelium and reduces the availability of bone marrow (BM)-derived endothelial progenitor cells (EPCs). | 27255499 |
| Tissue damage | Stem Cell Exhaustion | After birth, tissue stem cells maintain properly functioning tissues and organs under homeostasis as well as promote regeneration after tissue damage or injury. | 27256386 |
| Cerebrovascular accident | Stem Cell Exhaustion | Clinical Outcomes of Transplanted Modified Bone Marrow-Derived Mesenchymal Stem Cells in Stroke: A Phase 1/2a Study. | 27256670 |
| Cerebrovascular accident | Stem Cell Exhaustion | Eighteen patients with stable, chronic stroke were enrolled in a 2-year, open-label, single-arm study to evaluate the safety and clinical outcomes of surgical transplantation of modified bone marrow-derived mesenchymal stem cells (SB623). | 27256670 |
| Amyloidosis | Stem Cell Exhaustion | This long-term follow-up study aimed to assess the prognosis of systemic light chain amyloidosis (AL) patients treated with high-dose melphalan (HDM) chemotherapy and autologous stem cell transplantation, depending on iFISH results. | 27257181 |
| Diffuse alveolar hemorrhage, Vasculitis, Pulmonary Complication | Stem Cell Exhaustion | The diffuse alveolar hemorrhage (DAH) syndrome is a life-threatening pulmonary complication related to systemic vasculitides, posthematopoietic stem cell transplantation, drugs, or toxins. | 27261934 |
| MYELODYSPLASTIC SYNDROME, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Comparison of Intensive Chemotherapy and Hypomethylating Agents before Allogeneic Stem Cell Transplantation for Advanced Myelodysplastic Syndromes: A Study of the Myelodysplastic Syndrome Subcommittee of the Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplant Research. | 27264633 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | The European Society for Blood and Marrow Transplant Research data set was used to retrospectively analyze the outcomes of hypomethylating therapy (HMA) compared with those of conventional chemotherapy (CC) before hematopoietic stem cell transplantation (HSCT) in 209 patients with advanced myelodysplastic syndromes. | 27264633 |
| Lymphoma | Stem Cell Exhaustion | Effect of the addition of rituximab to salvage chemotherapy prior to autologous stem cell transplant in aggressive CD20+ lymphoma: a cohort comparison from the NCIC Clinical Trials Group Study LY.12. | 27266754 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | Circulating Progenitor Cells Identify Peripheral Arterial Disease in Patients With Coronary Artery Disease. | 27267067 |
| Atherosclerosis | Stem Cell Exhaustion | Decline in the number of bone marrow-derived circulating progenitor cells (PCs) is thought to contribute to the pathogenesis of atherosclerosis. | 27267067 |
| Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Ocular involvement of chronic graft-versus-host disease (cGVHD) is a complication that occurs in up to 60% of patients after allogeneic hematopoietic stem cell transplantation. | 27269196 |
| Rheumatoid Arthritis | Stem Cell Exhaustion | Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis (Cx611): results of a multicentre, dose escalation, randomised, single-blind, placebo-controlled phase Ib/IIa clinical trial. | 27269294 |
| Rheumatoid Arthritis | Stem Cell Exhaustion | To evaluate the safety and tolerability of the intravenous administration of Cx611, a preparation of allogeneic expanded adipose-derived stem cells (eASCs), in patients with refractory rheumatoid arthritis (RA), as well as to obtain preliminary clinical efficacy data in this population. | 27269294 |
| selenium | Stem Cell Exhaustion | Intensive chemotherapy and stem cell transplantation in MRD-based high-risk patients resulted in a significantly better 5-year EFS rate (78%, SE 8% v 16%, SE 8% in controls). | 27269950 |
| Werner Syndrome | Stem Cell Exhaustion | Vitamin C alleviates aging defects in a stem cell model for Werner syndrome. | 27271327 |
| ELN wt Allele | Stem Cell Exhaustion | We have recently developed a novel human WS model using WRN-deficient human mesenchymal stem cells (MSCs). | 27271327 |
| pulmonary toxicity, Neoplasms | Stem Cell Exhaustion | Aggressive Metastatic Inflammatory Myofibroblastic Tumor After Allogeneic Stem Cell Transplant With Fatal Pulmonary Toxicity From Crizotinib. | 27271810 |
| Neoplasm Metastasis | Stem Cell Exhaustion | IMTs are uncommon secondary malignancies after hematopoietic stem cell transplant. | 27271810 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | Sex-determining region Y-box binding protein-2 (SOX2) and aldehyde dehydrogenase-1 (ALDH1) are known cancer stem-cell markers, and represent candidate predictors for breast cancer prognosis. | 27272809 |
| Childhood Breast Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Backgroung/Aim: Breast cancer resistance protein [BCRP/ATP-binding cassette subfamily G member 2 (ABCG2)] is a member of the ATP-binding cassette transporter family, used as a maker of cancer stem cells (CSCs) and thought to be responsible for drug resistance by pumping them out of cells. | 27272814 |
| Somatic mosaicism | Stem Cell Exhaustion | Amplicon-based deep sequencing revealed somatic NLRP3 mosaicism restricted to myeloid cells (31.8% in monocytes, 24.6% in neutrophils, and 11.2% in circulating CD34+ common myeloid progenitor cells) and its complete absence in lymphoid cells. | 27273849 |
| Myeloproliferative disease, Primary Myelofibrosis, Fibrosis Assessment, Splenomegaly, PMF Regimen | Stem Cell Exhaustion | Primary myelofibrosis (PMF) is a Philadelphia-negative (Ph-) myeloproliferative disorder, showing abnormal CD34+ progenitor cell trafficking, splenomegaly, marrow fibrosis leading to extensive extramedullary haematopoiesis, and abnormal neoangiogenesis in either the bone marrow or the spleen. | 27281335 |
| Lymphoma | Stem Cell Exhaustion | Twenty Years of Autologous Stem Cell Transplantation in Diffuse Large B-Cell Lymphoma: A Single Portuguese Center Experience. | 27285096 |
| Adenocarcinoma of lung (disorder) | Stem Cell Exhaustion | Prognostic significance of stem cell-related marker expression and its correlation with histologic subtypes in lung adenocarcinoma. | 27285762 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cells (CSCs) are a small subset of tumor cells that exhibit stem cell-like properties and contribute in treatment failure. | 27285762 |
| Specialty Type - cancer | Stem Cell Exhaustion | Novel cancer stem cell targets during epithelial to mesenchymal transition in PTEN-deficient trastuzumab-resistant breast cancer. | 27285982 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Continued use of trastuzumab in PTEN-deficient HER2+ breast cancer induces the epithelial-to-mesenchymal transition (EMT), transforms HER2+ to triple negative breast cancer, and expands breast cancer stem cells (BCSCs). | 27285982 |
| Prostate | Stem Cell Exhaustion | Prostate tumor-induced angiogenesis is blocked by exosomes derived from menstrual stem cells through the inhibition of reactive oxygen species. | 27286448 |
| Neoplasms | Stem Cell Exhaustion | Mesenchymal stem cells (MSCs) secrete exosomes that are capable of modifying the tumor environment through different mechanisms including changes in the cancer-cell secretome. | 27286448 |
| Neoplasms | Stem Cell Exhaustion | Hence, we studied the angiogenic activity of menstrual stem cells (MenSCs)-secreted exosomes on prostate PC3 tumor cells. | 27286448 |
| Neurodevelopmental Disorders | Stem Cell Exhaustion | A Dichotomy of Information-Seeking and Information-Trusting: Stem Cell Interventions and Children with Neurodevelopmental Disorders. | 27286955 |
| Atrial Septal Defects | Stem Cell Exhaustion | The potential of stem cell technologies as an interventional strategy for CP and ASD has gained attention in the last decade. | 27286955 |
| Atrial Septal Defects | Stem Cell Exhaustion | In this study, we surveyed individuals who considered taking their child with ASD or CP abroad for stem cell interventions on their use of different sources of stem cell related health information and their level of trust in these sources. | 27286955 |
| Hematologic Neoplasms, Vancomycin-Resistant Enterococci | Stem Cell Exhaustion | Room contamination, patient colonization pressure, and the risk of vancomycin-resistant Enterococcus colonization on a unit dedicated to the treatment of hematologic malignancies and hematopoietic stem cell transplantation. | 27287734 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Whether these apply to modern units dedicated to the care of hematologic malignancies and hematopoietic stem cell transplant (HSCT) procedures is unknown. | 27287734 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Safety and efficacy of autologous thymosin b4 pre-treated endothelial progenitor cell transplantation in patients with acute ST segment elevation myocardial infarction: A pilot study. | 27288307 |
| Neoplasms | Stem Cell Exhaustion | Stromal cells in phyllodes tumors of the breast are enriched for EZH2 and stem cell marker expression. | 27290698 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Enhancer of Zeste 2 (EZH2) epigenetically regulates cell-type identity, cellular differentiation, and breast cancer stem cells. | 27290698 |
| Neoplasms | Stem Cell Exhaustion | Our study also suggests that PTs contain mesenchymal stem cells, shedding light into the pathogenesis of these tumors. | 27290698 |
| Multiple Sclerosis, Chronic Progressive | Stem Cell Exhaustion | Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial. | 27291994 |
| MS gene | Stem Cell Exhaustion | Strong immunosuppression, including chemotherapy and immune-depleting antibodies followed by autologous haemopoietic stem-cell transplantation (aHSCT), has been used to treat patients with multiple sclerosis, improving control of relapsing disease. | 27291994 |
| Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Outcome of allogeneic stem cell transplantation for AML and myelodysplastic syndrome in elderly patients (60 years). | 27295269 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Allogeneic stem cell transplantation (SCT) remains the best curative option for patients with refractory AML or with high-risk myelodysplastic syndrome (MDS). | 27295269 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Rituximab maintenance after autologous stem cell transplantation prolongs response duration in non-naive rituximab follicular lymphoma patients: a single institution experience. | 27297970 |
| Lymphoma, Follicular | Stem Cell Exhaustion | We retrospectively evaluated the role of rituximab (R) in maintenance treatment after autologous stem cell transplantation performed in patients with relapsed follicular lymphoma. | 27297970 |
| Haiti | Stem Cell Exhaustion | Autologous stem cell transplantation improved the outcomes of patients with HT (median overall survival, not reached v 1.7 years) but not of patients with persistent FL histology. | 27298402 |
| Haiti | Stem Cell Exhaustion | HT in patients with FL who previously responded to immunochemotherapy is an early event associated with a poor outcome that may deserve intensive salvage with autologous stem cell transplantation. | 27298402 |
| Teratoma | Stem Cell Exhaustion | By controlling telomere length of ES cells through telomerase inactivation, we can inhibit teratoma formation and potentially improve the safety of cell therapies involving terminally differentiated cells as well as specific progenitor cells that do not require sustained cellular proliferation in vivo, and thus sustained telomerase activity. | 27299710 |
| Osteoporosis | Stem Cell Exhaustion | Histone modification enzyme is chemically modifiable; therefore, PCAF may represent a novel therapeutic target for stem cell-mediated regenerative medicine and the treatment of osteoporosis. | 27300495 |
| Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | Reduced survival in patients with early-stage non-small-cell lung cancer is associated with high pleural endothelial progenitor cell levels. | 27301385 |
| Congestive heart failure, Pleural Effusion, CTCAE, Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | Pleural endothelial progenitor cell levels were quantified by fluorescence-activated cell sorting analysis in pleural effusion of 15 patients with late-stage non-small-cell lung cancer with pleural involvement and in 15 control patients with congestive heart failure. | 27301385 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer recurrence and survival was evaluated in patients with high pleural-drainage endothelial progenitor cell levels. | 27301385 |
| Lung diseases, Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | Also, pleural-drainage endothelial progenitor cell levels were higher in patients with non-small-cell lung cancer than in patients with benign lung disease undergoing pulmonary resection (P < 0.05). | 27301385 |
| Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | Non-small-cell lung cancer patients with high pleural-drainage endothelial progenitor cell levels had a significantly 4.9 higher rate of cancer recurrence/death than patients with lower pleural-drainage endothelial progenitor cell levels, irrespective of confounders. | 27301385 |
| Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | Endothelial progenitor cell levels are higher in the post-surgery pleural drainage of patients with non-small-cell lung cancer than in non-neoplastic pleural-drainage fluid. | 27301385 |
| Cessation of life, Non-Small Cell Lung Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | High pleural-drainage endothelial progenitor cell levels in patients undergoing pulmonary resection for early non-small-cell lung cancer predict an increased risk of cancer recurrence and death. | 27301385 |
| Neoplasms | Stem Cell Exhaustion | Endothelial progenitor cells are capable of contributing to neovascularization in tumours. | 27301385 |
| Pleural Effusion, CTCAE | Stem Cell Exhaustion | In patients with either malignant or transudative pleural effusion, we tested the presence of pleural endothelial progenitor cells. | 27301385 |
| Lung diseases, Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | We also measured the number of endothelial progenitor cells in post-surgery pleural drainage of either patients with early non-small-cell lung cancer or control patients with benign lung disease undergoing pulmonary resection. | 27301385 |
| Specialty Type - cancer | Stem Cell Exhaustion | The prospective influence of post-surgery pleural-drainage endothelial progenitor cells on cancer recurrence/survival was investigated. | 27301385 |
| Lung diseases, Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | Also, pleural-drainage endothelial progenitor cells were measured in pleural-drainage fluid 48 h after surgery in 64 patients with early-stage non-small-cell lung cancer and 20 benign lung disease patients undergoing pulmonary resection. | 27301385 |
| Pleural Effusion, CTCAE | Stem Cell Exhaustion | The number of pleural endothelial progenitor cells was higher in non-small-cell lung cancer pleural effusion than in transudative pleural effusion. | 27301385 |
| Congestive heart failure, Pleural Effusion, CTCAE, Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | Endothelial progenitor cells are present in the pleural effusion and are higher in patients with late-stage non-small-cell lung cancer with pleural involvement than in congestive heart failure patients. | 27301385 |
| leukemia, Multiple Myeloma | Stem Cell Exhaustion | On the basis of data showing KIR-ligand mismatched natural killer (NK) cells reduce the risk of leukemia and multiple myeloma relapse following allogeneic hematopoietic stem cell transplantation, investigators have developed a checkpoint inhibition antibody that blocks KIR on NK cells. | 27307594 |
| palladium | Stem Cell Exhaustion | In preparation for the clinical study we performed a cell tissue culture study with human embryonic stem cell (hESC)-derived midbrain dopamine (mDA) neurons that were treated with rotenone as a model for PD. | 27309537 |
| Autoimmune Diseases | Stem Cell Exhaustion | A Preliminary Online Study on Menstruation Recovery in Women After Autologous Hematopoietic Stem Cell Transplant for Autoimmune Diseases. | 27310497 |
| Autoimmune Diseases | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplant has become a successful treatment option in aggressive autoimmune diseases. | 27310497 |
| Autoimmune Diseases | Stem Cell Exhaustion | The aim of our study was to analyze information on menstruation recovery after autologous hematopoietic stem cell transplant for autoimmune diseases. | 27310497 |
| Autoimmune Diseases | Stem Cell Exhaustion | An anonymous online questionnaire was distributed among members of an international Web forum of patients who had autologous hematopoietic stem cell transplant for autoimmune disease. | 27310497 |
| Autoimmune Diseases | Stem Cell Exhaustion | However, a significant number of responders who underwent autologous hematopoietic stem cell transplant for autoimmune diseases already had children before transplant and indicated no desire for pregnancy after transplant; the data on pregnancy occurrence in this group should be interpreted in this context. | 27310497 |
| Erythema Infectiosum, Multiple Myeloma | Stem Cell Exhaustion | Chronic persistent parvovirus B19 bone marrow infection resulting in transfusion-dependent pure red cell aplasia in multiple myeloma after allogeneic haematopoietic stem cell transplantation and severe graft versus host disease. | 27311084 |
| Graft-vs-Host Disease, Steroid-Refractory Pneumonitis, human parvovirus B19 virus, Communicable Diseases | Stem Cell Exhaustion | We report a chronic persistent Parvovirus B19 (PVB19) infection despite long-term immunoglobulin substitution intravenous immunoglobulin (IVIG) and tapering of immune-suppressive therapy in a 41-year-old patient after allogeneic haematopoietic stem cell transplantation (alloHSCT) and long-term immune-suppressive therapy due to a steroid-refractory graft versus host disease (GvHD). | 27311084 |
| Pure Red-Cell Aplasia | Stem Cell Exhaustion | After 30 months, a bone marrow (BM) examination still revealed a highly dysplastic erythropoiesis without any cellular maturation, and a high-grade expression of PVB19 within the dysplastic erythropoietic progenitor cells, consistent with a PRCA due to a PVB19 infection of the BM. | 27311084 |
| Infection | Stem Cell Exhaustion | Invasive mold infections (IMIs) are major complications after allogeneic hematopoietic stem cell transplantation (HSCT) with high mortality. | 27311967 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Risk factors for a new IMI in multivariate analysis were older age, grades II to IV acute graft-versus-host disease (GVHD) (risk hazard, 4.1; 95% CI, 1.9 to 8.8; P < .001), treatment with mesenchymal stromal cells (risk hazard, 4.0; 95% CI, 2.1 to 7.8; P < .001), transplantation with female donor to male recipient (risk hazard, 2.2; 95% CI, 1.1 to 4.3; P = .02), and hematopoietic stem cell transplantation-specific comorbidity index over 5 (risk hazard, 2.8; 95% CI, 1.1 to 6.8; P = .03). | 27311967 |
| Medial collateral ligament, Mantle cell lymphoma | Stem Cell Exhaustion | Addition of high-dose cytarabine to immunochemotherapy before autologous stem-cell transplantation in patients aged 65 years or younger with mantle cell lymphoma (MCL Younger): a randomised, open-label, phase 3 trial of the European Mantle Cell Lymphoma Network. | 27313086 |
| Mantle cell lymphoma | Stem Cell Exhaustion | The European Mantle Cell Lymphoma Network aimed to investigate whether the introduction of high-dose cytarabine to immunochemotherapy before autologous stem-cell transplantation (ASCT) improves outcome. | 27313086 |
| Neoplasms, Malignant Neoplasms | Stem Cell Exhaustion | Notch signaling abnormalities are reported to be involved in the acceleration of malignancy in solid tumors and stem cell formation or regeneration in various organs. | 27315779 |
| Malignant neoplasm of liver | Stem Cell Exhaustion | The g-secretase inhibitors suppressed cell growth of the epithelial cell adhesion molecule-positive fraction in hepatoma cells, indicating that Notch inhibitors could suppress the stem cell features of liver cancer cells. | 27315779 |
| B-Cell Lymphomas | Stem Cell Exhaustion | The different roles of molecular classification according to upfront autologous stem cell transplantation in advanced-stage diffuse large B cell lymphoma patients with elevated serum lactate dehydrogenase. | 27324387 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | To investigate the role of molecular classification according to upfront autologous hematopoietic stem cell transplantation (ASCT), we retrospectively evaluated 219 newly diagnosed high-risk DLBCL patients. | 27324387 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Imatinib mesylate and new TKIs along with allogeneic stem cell transplantation and other factors have contributed to the life expectancy in patients with CML approaching that of the general population today. | 27325849 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Purpose This analysis of the FIRST trial in patients with newly diagnosed multiple myeloma (MM) ineligible for stem-cell transplantation examined updated outcomes and impact of patient age. | 27325857 |
| Dystrophy, "Stargardts disease | Stem Cell Exhaustion | A 60-year-old man with Stargardt's macular dystrophy and visual acuity of 20/400 in the right eye and 20/60 in the left eye underwent a subretinal injection of autologous bone marrow-derived stem cells in the right eye. | 27327294 |
| Retinal Detachment | Stem Cell Exhaustion | Retinal detachment may occur after subretinal injection of stem cells. | 27327294 |
| Cell Differentiation process, Teratoma | Stem Cell Exhaustion | An advantage of somatic cell differentiation without first generating induced pluripotent stem cells (iPSCs) is that it avoids contamination of the differentiated cells with residual iPSCs, which may cause teratoma. | 27328768 |
| Neoplasms | Stem Cell Exhaustion | Biomarker studies included immune subsets, circulating tumor cells (CTCs), circulating endothelial cells (CECs), circulating endothelial progenitor cells (CEPs), and osteopontin. | 27328856 |
| Liver carcinoma, Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Prognostic value of the expression of cancer stem cell-related markers CD133 and CD44 in hepatocellular carcinoma: From patients to patient-derived tumor xenograft models. | 27329727 |
| Liver carcinoma, Specialty Type - cancer, Hollings Cancer Center | Stem Cell Exhaustion | High expression of cancer stem cell (CSC) markers is related to poor prognosis of patients with hepatocellular carcinoma (HCC). | 27329727 |
| Graft-vs-Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Haplo-cord stem cell transplantation combines the infusion of CD34 selected hematopoietic progenitors from a haplo-identical donor with an umbilical cord blood (UCB) graft from an unrelated donor and allows faster count recovery, with low rates of disease recurrence and chronic graft-versus-host disease (GVHD). | 27333804 |
| Cataract | Stem Cell Exhaustion | The aging of lens progenitor cell has been repeatedly proposed to play a key role in age-related cataracts (ARCs), but the mechanism is far from being understood. | 27336873 |
| Cataract | Stem Cell Exhaustion | Only cortical cataract classification was found to be strongly related to the percentage of SA-b-gal and senescent HLECs.Our study gave the initial evidence on the dynamical change of lens stem/progenitor cells in human lens capsule with age and suggested that lens progenitor/epithelial cell aging is important in the severity of cortical cataracts. | 27336873 |
| Osteoporosis, Postmenopausal | Stem Cell Exhaustion | MiR-27a is Essential for the Shift from Osteogenic Differentiation to Adipogenic Differentiation of Mesenchymal Stem Cells in Postmenopausal Osteoporosis. | 27337099 |
| Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis | Stem Cell Exhaustion | Endothelial progenitor cells are differentially impaired in ANCA-associated vasculitis compared to healthy controls. | 27338585 |
| Crohn Disease | Stem Cell Exhaustion | Circulating Bone Marrow-Derived CD45-/CD34+/CD133+/VEGF+ Endothelial Progenitor Cells in Adults with Crohn's Disease. | 27339637 |
| Osteosarcoma | Stem Cell Exhaustion | Mesenchymal stem cells promote osteosarcoma cell survival and drug resistance through activation of STAT3. | 27340780 |
| Osteosarcoma, Neoplasms | Stem Cell Exhaustion | In this study, we tried to determine whether the mesenchymal stem cells (MSCs) in the tumor microenvironment contribute to the increased chemoresistance of osteosarcoma. | 27340780 |
| Specialty Type - cancer | Stem Cell Exhaustion | Identifying the CETC subset with cancer stem cell properties may provide more clinically useful prognostic information. | 27340862 |
| Specialty Type - cancer | Stem Cell Exhaustion | This population is termed cancer stem cells (CSCs). | 27340862 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | We have developed a simple method for identification and characterization of circulating cancer stem cells among circulating epithelial tumor cells (CETCs). | 27340862 |
| Specialty Type - cancer | Stem Cell Exhaustion | Analysis of surface marker expression profile of tumorspheres showed that cells in the spheres had typical phenotype of cancer stem cells. | 27340862 |
| Neoplasms | Stem Cell Exhaustion | Epstein-Barr virus-associated smooth muscle tumor of the cavernous sinus: a delayed complication of allogenic peripheral blood stem cell transplantation: case report. | 27341041 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | She had a prior history of acute myelogenous leukemia requiring allogenic peripheral blood stem cell transplantation 2 years earlier, but she was in a remission phase. | 27341041 |
| Specialty Type - cancer, Malignant neoplasm of liver | Stem Cell Exhaustion | The network of stemness genes and oncogenes in human patient-specific reprogrammed cancer stem cells (CSCs) remains elusive, especially in liver cancer. | 27341307 |
| Amyloidosis | Stem Cell Exhaustion | Induction therapy pre-autologous stem cell transplantation in immunoglobulin light chain amyloidosis: a retrospective evaluation. | 27341539 |
| Amyloidosis | Stem Cell Exhaustion | There is no consensus on whether patients with immunoglobulin light chain amyloidosis (AL) should receive induction therapy prior to an autologous stem cell transplant (ASCT). | 27341539 |
| Mycoses | Stem Cell Exhaustion | Baseline cytokine profiling identifies novel risk factors for invasive fungal disease among haematology patients undergoing intensive chemotherapy or haematopoietic stem cell transplantation. | 27343564 |
| Lymphoma | Stem Cell Exhaustion | Daily Weight-Based Busulfan with Cyclophosphamide and Etoposide Produces Comparable Outcomes to Four-Times-Daily Busulfan Dosing for Lymphoma Patients Undergoing Autologous Stem Cell Transplantation. | 27343718 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | To facilitate a therapeutic dose-monitoring protocol, we transitioned from Bu6 to daily Bu dosing for patients with Hodgkin and non-Hodgkin lymphoma undergoing autologous stem cell transplantation (ASCT). | 27343718 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Hematopoietic Progenitor Cell Mobilization with Ifosfamide, Carboplatin, and Etoposide Chemotherapy versus Plerixafor-Based Strategies in Patients with Hodgkin and Non-Hodgkin Lymphoma. | 27345140 |
| Lymphoma | Stem Cell Exhaustion | We analyzed hematopoietic progenitor cell mobilization outcomes in lymphoma patients undergoing chemo-mobilization with ICE (n = 35) compared with either routine plerixafor (n = 30) or "just in time" (JIT) plerixafor-based mobilization (n = 33). | 27345140 |
| Pick Disease of the Brain | Stem Cell Exhaustion | Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a P301L mutation in microtubule-associated protein tau (MAPT). | 27345788 |
| LIN28A wt Allele | Stem Cell Exhaustion | Induced pluripotent stem cells (iPSCs) were established by electroporation with episomal plasmids containing hOCT4, hSOX2, hKLF2, hL-MYC, hLIN-28 and shP53. | 27345788 |
| LIN28A wt Allele | Stem Cell Exhaustion | Induced pluripotent stem cell (iPSCs) were established by electroporation with episomal plasmids containing hOCT4, hSOX2, hKLF2, hL-MYC, hLIN-28 and shP53. | 27345791 |
| Pick Disease of the Brain | Stem Cell Exhaustion | Induced pluripotent stem cells (iPSCs) derived from a pre-symptomatic carrier of a R406W mutation in microtubule-associated protein tau (MAPT) causing frontotemporal dementia. | 27345791 |
| EN1 wt Allele, "Alzheimers Disease | Stem Cell Exhaustion | Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying a L150P mutation in PSEN-1. | 27345792 |
| Up, "Alzheimers Disease | Stem Cell Exhaustion | Induced pluripotent stem cells (iPSCs) were generated from skin fibroblasts isolated from a 58-year old male with a L150P mutation in the presenilin 1 (PSEN-1) gene, which is responsible for the majority of familial cases of Alzheimer's disease (AD). | 27345792 |
| Alzheimers Disease | Stem Cell Exhaustion | Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying an A79V mutation in PSEN1. | 27345973 |
| Alzheimers Disease | Stem Cell Exhaustion | Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying a M146I mutation in PSEN1. | 27345998 |
| Cerebral Hemorrhage | Stem Cell Exhaustion | Increased Endothelial Progenitor Cell Levels are Associated with Good Outcome in Intracerebral Hemorrhage. | 27346699 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | Within the transplant-eligible population, 52% of patients with DLBCL and 96% of patients with HL proceeded to stem cell transplantation. | 27347845 |
| Aplastic Anemia | Stem Cell Exhaustion | Comparable outcomes between younger (40 years) and older (>40 years) adult patients with severe aplastic anemia after HLA-matched sibling stem cell transplantation using fludarabine-based conditioning. | 27348538 |
| Aplastic Anemia | Stem Cell Exhaustion | Allogeneic stem cell transplantation from HLA-matched siblings (MSD-SCT) for elderly patients with severe aplastic anemia (SAA) is not a widely accepted first-line treatment. | 27348538 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Younger children are considered to be more vulnerable to late effects (LE), which prompted us to study LE in patients after haematopoietic stem cell transplantation (HSCT) for a haematological malignancy before the age of 3. | 27348540 |
| Choroid Diseases | Stem Cell Exhaustion | Cellular senescence as a result of organismal aging or progeroid diseases leads to stem cell pool exhaustion hindering tissue regeneration and contributing to the progression of age related disorders. | 27350449 |
| Lymphoma | Stem Cell Exhaustion | We compared VO2peak among lymphoma survivors (LSs) with reference data from healthy sedentary subjects, after a 10.2-year (mean) follow-up post high-dose chemotherapy with autologous stem cell transplantation (HDT-ASCT). | 27351215 |
| Colorectal Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | A Study on the Mechanism of Low-Expressed Cancer Stem Cell Marker Lgr5 in Inhibition of the Proliferation and Invasion of Colorectal Carcinoma. | 27352328 |
| Colorectal Carcinoma, Neoplasms, Cytogenetic Complete Response | Stem Cell Exhaustion | The present study intends to explore the influence of Lgr5 as a marker of tumor stem cells after siRNA interference on the proliferation and invasion of colorectal carcinoma (CRC) and its mechanism. | 27352328 |
| Leukemia, Myelomonocytic, Chronic | Stem Cell Exhaustion | The frequencies of TET2/DNMT3A and SRSF2 variants could support the hypothesis that TET2/DNMT3A mutations occurred in an early progenitor cell, which later progressed to both the AITL and CMML clones. | 27353473 |
| Malignant neoplasm of ovary, Specialty Type - cancer, Resistance Process | Stem Cell Exhaustion | Cancer Stem Cell Properties as Factors Predictive of Chemoresistance in Neoadjuvantly-treated Patients with Ovarian Cancer. | 27354603 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | The nuclear factor erytheroid 2-related factor 2-kelch-like ECH-associated protein (NRF2-KEAP1) system and stem cell-like cancer cells are associated with platinum resistance in ovarian cancer. | 27354603 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | Our objective was to investigate the possible association between platinum resistance, cellular redox-state regulation and stem cell properties in ovarian cancer. | 27354603 |
| Multiple Myeloma | Stem Cell Exhaustion | We identified 641 patients with multiple myeloma who had been treated using novel agents and/or autologous stem cell transplantation with high-dose chemotherapy between January 2006 and June 2014 at nine Japanese hospitals. | 27358178 |
| Small cell carcinoma of lung, Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Cancer Stem Cells, Epithelial to Mesenchymal Markers, and Circulating Tumor Cells in Small Cell Lung Cancer. | 27363902 |
| Neoplasms, Small cell carcinoma of lung, Specialty Type - cancer | Stem Cell Exhaustion | Elevated levels of circulating tumor cells (CTCs) have been associated with a worse prognosis, and markers of cancer stem cells (CSCs) and epithelial to mesenchymal transition have been associated with increased chemoresistance and metastatic spread in SCLC. | 27363902 |
| Lymphoma | Stem Cell Exhaustion | Retrospective evaluation of the MEAM regimen as a conditioning regimen before autologous peripheral blood stem cell transplantation for lymphoma in two centers with different dosing schedules of melphalan. | 27365141 |
| Lymphoma | Stem Cell Exhaustion | The BEAM regimen consisting of carmustine (BCNU), etoposide, cytarabine, and melphalan (MEL) is widely used before autologous hematopoietic stem cell transplantation (auto-HSCT) for lymphoma. | 27365141 |
| Hypertensive (finding), Chronic Kidney Disease, CTCAE | Stem Cell Exhaustion | Our aim was to characterize the endothelial progenitor cells (EPCs) in normotensive controls and treated hypertensive individuals within the vascular endothelial growth factor (VEGF) -460 C/T polymorphism as well as to investigate whether this polymorphism predisposes to hypertension-related chronic kidney disease. | 27367286 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | Differences in expression of the cancer stem cell marker aldehyde dehydrogenase 1 among estrogen receptor-positive/human epidermal growth factor receptor type 2-negative breast cancer cases with early, late, and no recurrence. | 27368476 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | The significance of the expression of aldehyde dehydrogenase 1 (ALDH1), a cancer stem cell marker, for predicting the recurrence of estrogen receptor (ER)-positive/human epidermal growth factor receptor type 2 (HER2)-negative breast cancer is still poorly understood. | 27368476 |
| Specialty Type - cancer | Stem Cell Exhaustion | Further study is needed to clarify the prognostic significance of the heterogeneity of cancer stem cells and to confirm their role in resistance to chemotherapy. | 27368476 |
| Functional Laterality | Stem Cell Exhaustion | Human neural progenitor cell applied treatment modalities may be an effective strategy to help maintain retinal functionality in neurodegenerative pathologies. | 27369448 |
| Photoreceptor degeneration | Stem Cell Exhaustion | Human neural progenitor cells decrease photoreceptor degeneration, normalize opsin distribution and support synapse structure in cultured porcine retina. | 27369448 |
| KMT2A gene, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The Superiority of Allogeneic Hematopoietic Stem Cell Transplantation Over Chemotherapy Alone in the Treatment of Acute Myeloid Leukemia Patients with Mixed Lineage Leukemia (MLL) Rearrangements. | 27373985 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Infusion of a non-HLA-matched ex-vivo expanded cord blood progenitor cell product after intensive acute myeloid leukaemia chemotherapy: a phase 1 trial. | 27374466 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Infusion of the expanded progenitor cell product seemed safe and might provide a promising treatment method for patients with acute myeloid leukaemia. | 27374466 |
| Infection | Stem Cell Exhaustion | We investigated the use of non-HLA-matched ex-vivo expanded cord blood progenitor cells to accelerate haemopoietic recovery and reduce infections after chemotherapy. | 27374466 |
| Toxic effect, Hypersensitivity | Stem Cell Exhaustion | We observed one case of acute infusional toxicity (attributed to an allergic reaction to dimethyl sulfoxide) in the 29 patients enrolled, who received 42 infusions of expanded progenitor cells. | 27374466 |
| Multiple Myeloma | Stem Cell Exhaustion | The effect of salvage autologous stem-cell transplantation on overall survival in patients with relapsed multiple myeloma (final results from BSBMT/UKMF Myeloma X Relapse [Intensive]): a randomised, open-label, phase 3 trial. | 27374467 |
| Multiple Myeloma | Stem Cell Exhaustion | The Myeloma X trial previously reported improved durability of response (time to disease progression) in patients with relapsed multiple myeloma with salvage autologous stem-cell transplantation (ASCT) compared with oral cyclophosphamide in patients with multiple myeloma relapsing after a first ASCT. | 27374467 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Allogeneic Hematopoietic Stem Cell Transplantation after Conditioning Regimens with Fludarabine/melphalan or Fludarabine/busulfan for Patients with Hematological Malignancies: A Single-center Analysis. | 27374671 |
| Fetal Measurements Domain | Stem Cell Exhaustion | Objective Fludarabine plus melphalan (FM) and fludarabine plus busulfan (FB) are two major conditioning regimens for allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 27374671 |
| Multiple Myeloma | Stem Cell Exhaustion | Autologous stem cell transplant for multiple myeloma patients 70 years or older. | 27376447 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Autologous stem cell transplant (Auto-SCT) is increasingly used in older patients with multiple myeloma (MM), despite lack of phase 3 trials in this age-defined population. | 27376447 |
| Lymphoma | Stem Cell Exhaustion | Risk factors predicting outcomes for primary refractory hodgkin lymphoma patients treated with salvage chemotherapy and autologous stem cell transplantation. | 27377168 |
| Hodgkin Disease, LIPC gene | Stem Cell Exhaustion | We aimed to identify risk factors that predict functional imaging (FI) response to salvage chemotherapy and evaluate outcomes following autologous stem cell transplant (ASCT) in primary refractory Hodgkin Lymphoma (HL). | 27377168 |
| Toxic nephropathy | Stem Cell Exhaustion | Their lack of renal toxicity makes them attractive regimens, which may be interesting for patients eligible for autologous stem cell transplantation. | 27377614 |
| Medial collateral ligament, Mantle cell lymphoma | Stem Cell Exhaustion | In recent decades, the prognosis of Mantle Cell Lymphoma (MCL) has been significantly improved by intensified first-line regimens containing cytarabine, rituximab and consolidation with high-dose-therapy and autologous stem cell transplantation. | 27378674 |
| Symptoms | Stem Cell Exhaustion | A retrospective chart review of 35 patients with a history of ocular GVHD following hematopoietic stem cell transplantation that used ASED to alleviate dry eye symptoms was performed. | 27380960 |
| Hematological Disease | Stem Cell Exhaustion | It is important for maintenance of stem cell homeostasis and its aberrant activation has been implicated in a wide array of malignant hematological disorders. | 27381374 |
| Corneal Scar, Corneal graft failure, Impaired T cell function | Stem Cell Exhaustion | The most common indication for surgery was corneal graft failure (n=23; 52.3%) followed by corneal scar (n=8; 18.2%) and limbal stem cell dysfunction (n=8; 18.2%). | 27381593 |
| Hodgkin Disease, Relapsing course | Stem Cell Exhaustion | Bendamustine in Combination With Gemcitabine and Vinorelbine Is an Effective Regimen As Induction Chemotherapy Before Autologous Stem-Cell Transplantation for Relapsed or Refractory Hodgkin Lymphoma: Final Results of a Multicenter Phase II Study. | 27382096 |
| Hodgkin Disease, LIPC gene | Stem Cell Exhaustion | This multicenter, open-label, phase II study evaluated the combination of bendamustine, gemcitabine, and vinorelbine (BeGEV) as induction therapy before autologous stem-cell transplantation (ASCT) in patients with relapsed or refractory Hodgkin lymphoma (HL). | 27382096 |
| Toxic effect | Stem Cell Exhaustion | Secondary end points were: overall response rate, stem-cell mobilization activity, and toxicity. | 27382096 |
| Hypertensive (finding) | Stem Cell Exhaustion | In addition, higher number of immature endothelial progenitor cells with CD34(+)CD133(+), CD34(+)CD133(-) markers was observed in GG hypertensive carriers while in normotensive individuals no differences were found. | 27382979 |
| Multiple Myeloma | Stem Cell Exhaustion | We evaluated 1070 patients with newly diagnosed multiple myeloma, who completed a single line of induction therapy followed by autologous stem cell transplantation. | 27390076 |
| Myeloid, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Mesenchymal Stem Cells (MSC) Regulate Activation of Granulocyte-Like Myeloid Derived Suppressor Cells (G-MDSC) in Chronic Myeloid Leukemia Patients. | 27391078 |
| Neoplasms, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | It is well known that mesenchymal stem cells (MSC) have a role in promotion of tumor growth, survival and drug-resistance in chronic myeloid leukemia (CML). | 27391078 |
| Malignant Head and Neck Neoplasm, leukemia | Stem Cell Exhaustion | Notch pathway plays a complex role depending on cellular contexts: promotes stem cell maintenance or induces terminal differentiation in potential cancer-initiating cells; acts as an oncogene in lymphocytes and mammary tissue or plays a growth-suppressive role in leukemia, liver, skin, and head and neck cancer. | 27391340 |
| Neurodegenerative Disorders | Stem Cell Exhaustion | Taken together, our data suggest that neonate NOG mice could be a sensitive animal platform to test tumorigenic potential of stem cell therapeutics and that ahMNCs could be a genetically stable stem cell source with little tumorigenic activity to develop regenerative treatments for neurodegenerative diseases. | 27391353 |
| Neurodegenerative Disorders | Stem Cell Exhaustion | Stem cells and therapeutic genes are emerging as a new therapeutic approach to treat various neurodegenerative diseases with few effective treatment options. | 27391353 |
| Neoplasms | Stem Cell Exhaustion | However, potential formation of tumors by stem cells has hampered their clinical application. | 27391353 |
| Multiple Myeloma, Osteomyelitis | Stem Cell Exhaustion | We present a case of fungal osteomyelitis caused by Lasiodiplodia species in a patient with multiple myeloma after autologous stem cell transplant. | 27391908 |
| Specialty Type - cancer | Stem Cell Exhaustion | We evaluated the relationships between PD-L1 positivity, several clinical factors and the immunohistochemical expression of epithelial-mesenchymal transition (EMT), cancer stem cell and proliferative markers. | 27393509 |
| Stem Cell Factor, Tumor necrosis | Stem Cell Exhaustion | We compare serum interleukin (IL)-3, IL-6, IL-11, thrombopoietin (Tpo), stem cell factor (SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF), tumour necrosis factor-a (TNFa), and spleen size between these two groups. | 27396368 |
| Inflammation | Stem Cell Exhaustion | Intradialytic aerobic cycling exercise alleviates inflammation and improves endothelial progenitor cell count and bone density in hemodialysis patients. | 27399127 |
| Metachromatic leukodystrophy, juvenile type | Stem Cell Exhaustion | Long-term Outcome of Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Juvenile Metachromatic Leukodystrophy Compared With Nontransplanted Control Patients. | 27400410 |
| ARSA wt Allele, Metachromatic leukodystrophy, juvenile type | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (HSCT) has been the only treatment option clinically available during the last 20 years for juvenile metachromatic leukodystrophy (MLD), reported with variable outcome and without comparison with the natural course of the disease. | 27400410 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Selective depletion (SD) of alloreactive T cells from allogeneic hematopoeitic stem cell transplants to prevent graft-versus-host disease (GVHD) without compromising immune reconstitution and antitumor responses remains a challenge. | 27401140 |
| Cardiovascular Diseases | Stem Cell Exhaustion | Cilostazol Enhances Mobilization of Circulating Endothelial Progenitor Cells and Improves Endothelium-Dependent Function in Patients at High Risk of Cardiovascular Disease. | 27401788 |
| Cardiovascular Diseases, Cyclophosphamide/Vincristine/Dacarbazine Regimen | Stem Cell Exhaustion | This is the first study to investigate the vasculoangiogenic effects of cilostazol on endothelial progenitor cells (EPCs) and flow-mediated dilatation (FMD) in patients at high risk of cardiovascular disease (CVD). | 27401788 |
| Alexander Disease | Stem Cell Exhaustion | We established induced pluripotent stem cells from Alexander disease patients, and differentiated induced pluripotent stem cells into astrocytes. | 27402089 |
| Alexander Disease | Stem Cell Exhaustion | Astrocytes, differentiated from induced pluripotent stem cells of Alexander disease, could be a cellular model for future translational medicine. | 27402089 |
| BONE MARROW FAILURE SYNDROME 1, Aplastic Anemia | Stem Cell Exhaustion | Aplastic anaemia (AA) is a rare acquired bone marrow failure syndrome resulting from the immune-mediated destruction of haemopoietic stem cells. | 27404498 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Results of a 2-arm, phase 2 clinical trial using post-transplantation cyclophosphamide for the prevention of graft-versus-host disease in haploidentical donor and mismatched unrelated donor hematopoietic stem cell transplantation. | 27404668 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | High-dose, post-transplantation cyclophosphamide (PTCy) to prevent graft-versus-host disease (GVHD) has improved outcomes in haploidentical (HAPLO) stem cell transplantation (SCT). | 27404668 |
| Mucopolysaccharidoses, Mucopolysaccharidosis I | Stem Cell Exhaustion | Hematopoietic stem cell transplants, alongside enzyme replacement therapy and good multi-disciplinary care, have dramatically improved the life expectancy in children with Mucopolysaccharidosis (MPS) I, with better objective and functional outcomes. | 27406185 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Loss of donor-mediated immune antitumor activity after allogeneic hematopoietic stem-cell transplantation (HSCT) permits relapse of hematologic cancers. | 27410923 |
| Colorectal Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer. | 27411517 |
| Specialty Type - cancer | Stem Cell Exhaustion | Using our in vitro model, we found that SOX2 expressing cells displayed several characteristics of cancer stem cells; such as a decreased proliferative rate, a spheroid growth pattern, and increased expression of stem cell markers CD24 and CD44. | 27411517 |
| Chronic heart failure | Stem Cell Exhaustion | Prognostic relevance of circulating endothelial progenitor cells in patients with chronic heart failure. | 27412580 |
| Endothelium | Stem Cell Exhaustion | Endothelial progenitor cells (EPCs) are an important endogenous repair mechanism with the ability to counteract endothelial injury and the possibility of new vessel formation. | 27412580 |
| Hypertensive (finding) | Stem Cell Exhaustion | Taurine and magnesium supplementation enhances the function of endothelial progenitor cells through antioxidation in healthy men and spontaneously hypertensive rats. | 27412799 |
| Cardiovascular Diseases | Stem Cell Exhaustion | Endothelial damage is repaired by endothelial progenitor cells (EPCs), which are pivotal in preventing cardiovascular diseases and prolonging lifespan. | 27412799 |
| Specialty Type - cancer, Adenocarcinoma of pancreas | Stem Cell Exhaustion | Co-Expression of Cancer Stem Cell Markers Corresponds to a Pro-Tumorigenic Expression Profile in Pancreatic Adenocarcinoma. | 27414409 |
| Specialty Type - cancer | Stem Cell Exhaustion | Its dismal prognosis is often attributed to the presence of cancer stem cells (CSCs) that have been identified in PDAC using various markers. | 27414409 |
| Best Case Imputation Technique, Therapy-related myelodysplastic syndrome | Stem Cell Exhaustion | We found elevated t-MDS risk especially among younger BC patients with stem cell transplantation the only observed curative treatment. | 27414978 |
| Dyslipidemias | Stem Cell Exhaustion | We studied the effect of rosuvastatin monotherapy or its combination with omega-3 polyunsaturated fatty acids (o-3 PUFAs) on progenitor cell number and function in patients with mixed dyslipidaemia. | 27415612 |
| Dyslipidemias | Stem Cell Exhaustion | Effect of rosuvastatin or its combination with omega-3 fatty acids on circulating CD34(+) progenitor cells and on endothelial colony formation in patients with mixed dyslipidaemia. | 27415612 |
| Hypercholesterolemia | Stem Cell Exhaustion | Hypercholesterolaemia is associated with a reduced number of circulating progenitor cells, a defect that is restored by statin therapy. | 27415612 |
| Bacteremia, Specialty Type - cancer | Stem Cell Exhaustion | All episodes of bacteraemia occurring in hospitalized patients with cancer, including haematopoietic stem cell transplant recipients, from January 2006 to April 2015 were included. | 27417156 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Myelodysplastic syndrome (MDS) is a clonal stem cell disorder frequently associated with inefficient granulopoiesis showing dysplastic polymorphonuclear neutrophils (PMNs). | 27417453 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | These findings suggest that polaprezinc lozenge is simple to apply and highly effective for prevention of oral mucositis associated with high-dose chemotherapy for hematopoietic stem cell transplantation. | 27418192 |
| Polycystic Kidney, Autosomal Dominant | Stem Cell Exhaustion | We here generated induced pluripotent stem cells (iPSCs) from seven ADPKD patients, including four with ICAs. | 27418197 |
| Restenosis, Thrombosis | Stem Cell Exhaustion | With additional endothelial progenitor cell-capturing technology, the Combo stent exhibits a unique late neointimal regression (from 9 to 24 months) that has not been reported in any drug-eluting stents, translating into good 36-month clinical results with minimal restenosis and no late stent thrombosis. | 27418609 |
| Multiple Myeloma | Stem Cell Exhaustion | Outcomes in patients with multiple myeloma with TP53 deletion after autologous hematopoietic stem cell transplant. | 27420405 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Evolution of acute myelogenous leukemia stem cell properties after treatment and progression. | 27421961 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We prospectively characterized leukemia stem cell populations (LSCs) from a well-defined cohort of patients with acute myelogenous leukemia (AML) at diagnosis and relapse to assess the effect of the disease course on these critical populations. | 27421961 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells have been postulated to represent a therapy-refractory reservoir for relapse, but formal proof of this model is lacking. | 27421961 |
| Thrombocytosis, Polycythemia Vera, Primary Myelofibrosis | Stem Cell Exhaustion | To get further insight in the dynamics of the mutant clone, we assessed the mutant allele burden in hematopoietic stem cells (HSCs), hematopoietic progenitor cells (HPCs) and granulocytes from 138 patients [51 polycythemia vera (PV), 58 essential thrombocythemia (ET) and 29 myelofibrosis (MF)]. | 27427771 |
| JAK2 NP_004963.1:p.V617F, Myeloproliferative disease | Stem Cell Exhaustion | Characterization of CD34+ hematopoietic progenitor cells in JAK2V617F and CALR-mutated myeloproliferative neoplasms. | 27427771 |
| Failure | Stem Cell Exhaustion | A multicenter trial of myeloablative clofarabine and busulfan conditioning for relapsed or primary induction failure AML not in remission at the time of allogeneic hematopoietic stem cell transplantation. | 27427921 |
| Amyotrophic Lateral Sclerosis, Antilymphocyte Serum | Stem Cell Exhaustion | Modeling amyotrophic lateral sclerosis (ALS) with human induced pluripotent stem cells (iPSCs) aims to reenact embryogenesis, maturation and aging of spinal motor neurons (spMNs) in vitro. | 27428653 |
| Adenovirus Infections | Stem Cell Exhaustion | Occurrence, risk factors and outcome of adenovirus infection in adult recipients of allogeneic hematopoietic stem cell transplantation. | 27428881 |
| Adenovirus Infections, Hematological Disease | Stem Cell Exhaustion | We retrospectively analyzed occurrence and risk factors of ADV infection in 399 adults with hematological disorders undergoing hematopoietic stem cell transplantation (allo-HSCT), focusing on alternative donor transplantation (ADT) and disseminated disease. | 27428881 |
| MS gene | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplantation in combination with immunoablative protocol in secondary progressive multiple sclerosis--A 10-year follow-up of the first transplanted patient. | 27430119 |
| Infection | Stem Cell Exhaustion | An increase in respiratory syncytial virus type B (RSV-B) infections was detected on an adult hematology/oncology and stem cell transplant unit during March 2015. | 27430734 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | The role of ELAM-1 gene in mediating the adhesion of tumor cells to endothelial cells by binding to ELAM-1 ligands expressed by eosinophils, neutrophils, monocytes, natural killer cell effectors, T lymphocyte cells, and cancer (progenitor/stem) cells is well studied. | 27433816 |
| Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Cord blood (CB) offers a number of advantages over other sources of hematopoietic stem cells, including a lower rate of chronic graft-versus-host disease (cGVHD) in the presence of increased HLA disparity. | 27439912 |
| B-Cell Lymphomas | Stem Cell Exhaustion | Clinical impact of early recovery of peripheral blood absolute lymphocyte count after frontline autologous stem cell transplantation for diffuse large B-cell lymphoma. | 27440113 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | We conducted a retrospective study to evaluate the clinical impact of an early recovery of posttransplant absolute lymphocyte count (ALC) on the outcome of frontline autologous stem cell transplantation (ASCT) for diffuse large B-cell lymphoma (DLBCL). | 27440113 |
| Cerebral Infarction | Stem Cell Exhaustion | In an animal model of transient cerebral ischemia, application of oligodendrocyte progenitor cells (OPCs) has not yet been reported. | 27442084 |
| Social security number, Neoplasms | Stem Cell Exhaustion | To describe the utility of simple limbal epithelial transplantation (SLET) along with tumor excision in the management of extensive ocular surface squamous neoplasia (OSSN) to avoid limbal stem cell deficiency (LSCD). | 27442321 |
| Post-transplant lymphoproliferative disorder | Stem Cell Exhaustion | Post-transplant lymphoproliferative disorder arose after hematopoietic stem cell transplant in five and solid organ transplant in 27 patients, a median of 4 and 96 months after transplant, respectively (overall median latency 71 months, range 2-295). | 27443517 |
| Cardiotoxicity | Stem Cell Exhaustion | The human amniotic fluid stem cell secretome effectively counteracts doxorubicin-induced cardiotoxicity. | 27444332 |
| Cardiotoxicity | Stem Cell Exhaustion | These results support the concept that hAFS are a valuable source of cardioprotective factors and lay the foundations for the development of a stem cell-based paracrine treatment of chemotherapy-related cardiotoxicity. | 27444332 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | The secretome of human amniotic fluid-derived stem cells (hAFS) has previously been demonstrated to significantly reduce ischemic cardiac damage. | 27444332 |
| Malignant Peripheral Nerve Sheath Tumor, Myeloproliferative disease | Stem Cell Exhaustion | Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by the proliferation of one or more myeloid lineages. | 27444979 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | Dysregulation of Vascular Endothelial Progenitor Cells Lung-Homing in Subjects with COPD. | 27445517 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | We investigated the hypothesis that lower circulating numbers of vascular endothelial progenitor cells (VEPCs) are a consequence of increased lung-sequestration in COPD. | 27445517 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | Increased migrational responsiveness of progenitor cells may promote lung-homing of VEPC in COPD which may disrupt maintenance and repair of the airways and contribute to COPD disease pathogenesis. | 27445517 |
| Toxic effect, Fanconi Anemia | Stem Cell Exhaustion | Hematopoietic Stem Cell Transplant in Adolescent and Young Adults With Fanconi Anemia Is Feasible With Acceptable Toxicity, With Those Surviving 100 Days Posttransplant Having Excellent Outcomes. | 27447289 |
| Bone marrow hypocellularity, Fanconi Anemia | Stem Cell Exhaustion | Hematopoietic stem cell transplant is a potentially curative modality for bone marrow failure in Fanconi anemia patients. | 27447289 |
| Fanconi Anemia | Stem Cell Exhaustion | Here, we report our center's experience regarding adolescent and young adult patients with Fanconi anemia and hematopoietic stem cell transplant. | 27447289 |
| Fanconi Anemia | Stem Cell Exhaustion | We included patients greater than 14 years old with confirmed Fanconi anemia based on positive chromosome breakage study and who underwent hematopoietic stem cell transplant at our institution. | 27447289 |
| Fanconi Anemia | Stem Cell Exhaustion | Our study group comprised 12 patients with Fanconi anemia who underwent hematopoietic stem cell transplant at our institution. | 27447289 |
| Acute GVH disease, Pregnancy Complications, Infectious | Stem Cell Exhaustion | Three patients (25%) died early before day 100 after hematopoietic stem cell transplant due to infectious complications, with 1 patient having steroid refractory acute graft-versus-host disease. | 27447289 |
| Fanconi Anemia | Stem Cell Exhaustion | Our findings support the feasibility of reduced intensity conditioning allogeneic hematopoietic stem cell transplant in older and more heavily pretreated patients with Fanconi anemia, especially for those who are engrafted. | 27447289 |
| Malignant neoplasm of liver | Stem Cell Exhaustion | Overexpression of FGF19/FGFR4 significantly correlated with EpCAM as a marker of hepatic cancer stem cells within the fatty liver-steatosis-cirrhosis-HCC sequence. | 27447573 |
| Coronary Arteriosclerosis, Vascular System Injuries, Corneal Endothelial Cell Loss | Stem Cell Exhaustion | Circulating endothelial progenitor cells (EPCs), which have the ability to differentiate into mature endothelial cells, can elicit angiogenesis, vasculogenesis and vessel repair in cardiac ischemia and vascular injuries caused by endothelial damage. | 27447811 |
| Prostate carcinoma, Secondary Neoplasm | Stem Cell Exhaustion | Aromatic Hydrocarbon Receptor Suppresses Prostate Cancer Bone Metastasis Cells-Induced Vasculogenesis of Endothelial Progenitor Cells under Hypoxia. | 27448695 |
| Secondary malignant neoplasm of prostate | Stem Cell Exhaustion | The purpose of this study was to explore whether AHR can suppress hypoxia-induced VEGF production in prostate bone metastasis cells and repress neovascularization in endothelial progenitor cells (EPCs), and, if so, through what mechanisms. | 27448695 |
| Malignant tumor of colon | Stem Cell Exhaustion | Pregnane X-receptor promotes stem cell-mediated colon cancer relapse. | 27448961 |
| Colorectal Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Colorectal cancer lethality usually results from post-treatment relapse in the majority of stage II-IV patients, due to the enhanced resistance of Cancer Stem Cells (CSCs). | 27448961 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | There is increasing evidence supporting the cancer stem cell (CSC) hypothesis, which suggests that a population of tumor cells with stem cell characteristics is responsible for tumor growth, resistance, and recurrence as well as drug resistance. | 27449042 |
| Glioblastoma | Stem Cell Exhaustion | Immunohistochemical expression of stem cell markers CD44 and nestin in glioblastomas: Evaluation of their prognostic significance. | 27450656 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | The response to therapy is variable and may be affected by the presence, within the tumor, of a proportion of cancer stem cells, implicated in chemo- and radioresistance. | 27450656 |
| Hodgkin Disease, Failure | Stem Cell Exhaustion | Nivolumab for classical Hodgkin's lymphoma after failure of both autologous stem-cell transplantation and brentuximab vedotin: a multicentre, multicohort, single-arm phase 2 trial. | 27451390 |
| Hodgkin Disease, Failure | Stem Cell Exhaustion | We aimed to assess the clinical benefit and safety of nivolumab monotherapy in patients with classical Hodgkin's lymphoma after failure of both autologous stem-cell transplantation and brentuximab vedotin. | 27451390 |
| Hodgkin Disease | Stem Cell Exhaustion | In this ongoing, single-arm phase 2 study, adult patients (aged >=18 years) with recurrent classical Hodgkin's lymphoma who had failed to respond to autologous stem-cell transplantation and had either relapsed after or failed to respond to brentuximab vedotin, and with an Eastern Cooperative Oncology Group performance status score of 0 or 1, were enrolled from 34 hospitals and academic centres across Europe and North America. | 27451390 |
| Hodgkin Disease | Stem Cell Exhaustion | Nivolumab resulted in frequent responses with an acceptable safety profile in patients with classical Hodgkin's lymphoma who progressed after autologous stem-cell transplantation and brentuximab vedotin. | 27451390 |
| Bone necrosis | Stem Cell Exhaustion | A 21-year-old man, allogeneic hematopoietic stem cell transplantation recipient, was referred to our nuclear medicine department for a suspicion of knee osteonecrosis. | 27454596 |
| Heart failure, Ischemic cardiomyopathy, Coronary Arteriosclerosis, Myocardial Ischemia | Stem Cell Exhaustion | To determine whether the presence of ischemic heart disease (IHD) per se, or rather the co-presence of heart failure (HF), is the primum movens for less effective stem cell products in autologous stem cell therapy, we assessed numbers and function of bone marrow (BM)-derived progenitor cells in patients with coronary artery disease (n = 17), HF due to ischemic cardiomyopathy (n = 8), non-ischemic HF (n = 7), and control subjects (n = 11). | 27456951 |
| Cardiomyopathies, Myocardial Ischemia | Stem Cell Exhaustion | Hence, IHD, with or without associated cardiomyopathy, is an important determinant of progenitor cell function. | 27456951 |
| Heart Diseases | Stem Cell Exhaustion | Bone Marrow-Derived Progenitor Cells Are Functionally Impaired in Ischemic Heart Disease. | 27456951 |
| Myocardial Ischemia | Stem Cell Exhaustion | No depletion of hematopoietic and endothelial progenitor cells (EPC) within the BM was observed, while circulating EPC numbers were increased in the presence of IHD, suggesting active recruitment. | 27456951 |
| Neoplasms | Stem Cell Exhaustion | Xenograft PDAC tumor models were established in mice by inoculation of CD133+ stem cells isolated from PDAC tumors. | 27458977 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | A useful method of gastric cancer stem cell (CSC) characterization is spheroid colony formation. | 27459100 |
| Behavior of tumor, Childhood Breast Carcinoma | Stem Cell Exhaustion | Spindle-shaped stromal cells, like carcinoma-associated fibroblasts and mesenchymal stem cells, influence tumor behavior and can serve as parameters in the clinical diagnosis, therapy, and prognosis of early breast cancer. | 27460086 |
| Degenerative polyarthritis | Stem Cell Exhaustion | We assessed the clinical outcomes through osteoarthritis outcome score (KOOS) and the inflammatory response by quantifying mesenchymal stem cells in synovial fluid. | 27462609 |
| Osteoarthritis, Knee, Usual Severity Pain | Stem Cell Exhaustion | Intra-articular injections combined with intraosseous infiltrations of platelet rich plasma reduce pain and mesenchymal stem cells in synovial fluid, besides significantly improving knee joint function in patients with severe knee osteoarthritis. | 27462609 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease after radiation therapy in patients who have undergone allogeneic stem cell transplantation: two case reports. | 27465468 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Patients who undergo allogeneic stem cell transplantation and subsequent radiation therapy uncommonly develop graft-versus-host disease within the irradiated area. | 27465468 |
| Hodgkin Disease | Stem Cell Exhaustion | The first patient is a 37-year-old white man who had Hodgkin lymphoma; he underwent allogeneic stem cell transplantation from a matched unrelated donor and received radiation therapy for an abdominal and pelvic nodal recurrence. | 27465468 |
| Acute leukemia | Stem Cell Exhaustion | The other patient is a 24-year-old white man who had acute leukemia; he underwent allogeneic stem cell transplantation from a matched related donor and received craniospinal irradiation for a central nervous system relapse. | 27465468 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | We conclude that graft-versus-host disease within irradiated tissues is an uncommon but potentially serious complication that may follow radiation therapy in patients who have undergone allogeneic stem cell transplantation. | 27465468 |
| Inflammation | Stem Cell Exhaustion | Patients who have undergone allogeneic stem cell transplantation represent a unique population that may offer novel insight into the pathways involved in radiation-related inflammation. | 27465468 |
| FLT3 Internal Tandem Duplication, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | FLT3/ITD+ AML cases were sorted into two putative LSC populations according to the expression of CD123 and analyzed for FLT3/ITD again in the stem cell fractions CD34+/CD38-/CD123+ and CD34+/CD38-/CD123-. | 27465508 |
| leukemia | Stem Cell Exhaustion | Xenograft transplantation studies have demonstrated a rare population of leukemia-initiating cells called leukemic stem cells (LSCs) capable of propagating leukemia that are enriched in the CD34+/CD38- fraction. | 27465508 |
| Broca Aphasia | Stem Cell Exhaustion | Severe motor aphasia after reinfusion of cryopreserved autologous stem cells after myeloablative conditioning. | 27465621 |
| Specialty Type - cancer, Pancreatic carcinoma | Stem Cell Exhaustion | Double cortin-like kinase 1 (DCLK1) is a promising therapeutic target and cancer stem cell marker, predominantly investigated in pancreatic and colorectal cancer. | 27470117 |
| Malignant neoplasm of salivary gland, Specialty Type - cancer | Stem Cell Exhaustion | Therefore, little is known about biomarkers and cancer stem cells in salivary gland malignancies. | 27470117 |
| Cytomegalovirus Infections, Graft-vs-Host Disease | Stem Cell Exhaustion | Therefore, we retrospectively studied the impact of latent or active CMV infections on the outcome and occurrence of graft-versus-host disease (GVHD) after reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (SCT) in 294 patients during the period from 2004 to 2010. | 27470287 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We carried out post-transplantation cyclophosphamide (PTCy)-based haploidentical peripheral blood stem cell transplantation in 51 patients with refractory/relapsed acute myeloid leukemia not in remission. | 27470289 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Our study shows that early administration of G-DLI is feasible after PTCy-based haploidentical hematopoietic stem cell transplantation for refractory/relapsed acute myeloid leukemia and might be associated with improved survival after MAC. | 27470289 |
| Decreased platelet count | Stem Cell Exhaustion | Platelet-Derived Growth Factor-BB Protects Mesenchymal Stem Cells (MSCs) Derived From Immune Thrombocytopenia Patients Against Apoptosis and Senescence and Maintains MSC-Mediated Immunosuppression. | 27471307 |
| Impaired | Stem Cell Exhaustion | Mesenchymal stem cells (MSCs) from ITP patients (MSC-ITP) do not exhibit conventional proliferative abilities and thus exhibit defects in immunoregulation, suggesting that MSC impairment might be a mechanism involved in ITP. | 27471307 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Pretransplant NPM1 MRD levels predict outcome after allogeneic hematopoietic stem cell transplantation in patients with acute myeloid leukemia. | 27471865 |
| Acute myeloid leukemia with mutated NPM1 | Stem Cell Exhaustion | The objective was to evaluate the prognostic impact of pre-transplant minimal residual disease (MRD) as determined by real-time quantitative polymerase chain reaction in 67 adult NPM1-mutated acute myeloid leukemia patients receiving allogeneic hematopoietic stem cell transplantation (HSCT). | 27471865 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | First-line therapy of peripheral T-cell lymphoma: extension and long-term follow-up of a study investigating the role of autologous stem cell transplantation. | 27471868 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | Current guidelines recommend consolidation with autologous stem cell transplantation (autoSCT) after induction chemotherapy for most patients with peripheral T-cell lymphoma (PTCL). | 27471868 |
| Hodgkin Disease | Stem Cell Exhaustion | Brentuximab vedotin in relapsed/refractory Hodgkin lymphoma post-autologous stem cell transplant: a cost-effectiveness analysis in Scotland. | 27472034 |
| Hodgkin Disease | Stem Cell Exhaustion | To evaluate cost-effectiveness of brentuximab vedotin in patients with relapsed/refractory Hodgkin lymphoma who have received autologous stem cell transplantation, from a Scottish healthcare payer perspective. | 27472034 |
| Chronic Lymphocytic Leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment approach for patients with acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL). | 27473564 |
| Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | Cancer stem cells (CSCs) play a pivotal role in progression, metastasis and recurrence of cancer. | 27473646 |
| Failure, Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | To evaluate the location and timing of initial recurrence in patients with diffuse large B-cell lymphoma (DLBCL) who subsequently underwent high-dose chemotherapy with autologous stem cell transplant (HDC/ASCT), to direct approaches for disease surveillance, elucidate the patterns of failure of contemporary treatment strategies, and guide adjuvant treatment decisions. | 27473813 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Epigenetic alteration may play a role in age-associated dysfunction of stem cells and predispose to the development of hematological cancers. | 27475703 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | High-dose chemotherapy with autologous haemopoietic stem cell transplantation for newly diagnosed primary CNS lymphoma: a prospective, single-arm, phase 2 trial. | 27476790 |
| Crohn Disease, Perianal fistula | Stem Cell Exhaustion | Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial. | 27477896 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Clinical Utility of Next-Generation Sequencing for Oncogenic Mutations in Patients with Acute Myeloid Leukemia Undergoing Allogeneic Stem Cell Transplantation. | 27478011 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | To determine the association of somatic mutations in acute myeloid leukemia (AML) with risk of relapse after allogeneic hematopoietic stem cell transplantation (alloHSCT), we retrospectively studied pre-transplantation genetic profiles obtained from next-generation sequencing of 26 genes in 112 adult patients with AML who underwent alloHSCT. | 27478011 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Protein kinase CK2 regulates AKT, NF-kB and STAT3 activation, stem cell viability and proliferation in acute myeloid leukemia. | 27479180 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Protein kinase CK2 sustains acute myeloid leukemia cell growth, but its role in leukemia stem cells is largely unknown. | 27479180 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Here, we discovered that the CK2 catalytic a and regulatory b subunits are consistently expressed in leukemia stem cells isolated from acute myeloid leukemia patients and cell lines. | 27479180 |
| leukemia | Stem Cell Exhaustion | CK2 inactivation with the selective inhibitor CX-4945 or RNA interference induced an accumulation of leukemia stem cells in the late S-G2-M phases of the cell cycle and triggered late-onset apoptosis. | 27479180 |
| leukemia | Stem Cell Exhaustion | As a result, leukemia stem cells displayed an increased sensitivity to the chemotherapeutic agent doxorubicin. | 27479180 |
| leukemia | Stem Cell Exhaustion | Notably, combined CK2 and either NF-kB or STAT3 inhibition resulted in a superior cytotoxic effect on leukemia stem cells. | 27479180 |
| Bacterial Infections | Stem Cell Exhaustion | Bacterial infections in pediatric hematopoietic stem cell transplantation recipients: incidence, epidemiology, and spectrum of pathogens: report of the Polish Pediatric Group for Hematopoietic Stem Cell Transplantation. | 27479544 |
| Graft-vs-Host Disease, Failure | Stem Cell Exhaustion | Infectious complications are a significant cause of hematopoietic stem cell transplantation (HSCT) failure, especially allogeneic HSCT (allo-HSCT) because of delayed immune reconstitution and graft-versus-host disease (GVHD) occurrence. | 27479544 |
| Viral respiratory infection | Stem Cell Exhaustion | Universal Mask Usage for Reduction of Respiratory Viral Infections After Stem Cell Transplant: A Prospective Trial. | 27481873 |
| Viral respiratory infection | Stem Cell Exhaustion | Respiratory viral infections (RVIs) are frequent complications of hematopoietic stem cell transplant (HSCT). | 27481873 |
| Multiple Myeloma | Stem Cell Exhaustion | Cost analysis of a randomized stem cell mobilization study in multiple myeloma. | 27485453 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Upfront autologous stem cell transplantation (ASCT) is the standard therapy for younger multiple myeloma (MM) patients. | 27485453 |
| Specialty Type - cancer | Stem Cell Exhaustion | Children with a history of cancer and/or hematopoietic stem cell transplant had higher mortality (47% vs 11%; p < 0.001). | 27487912 |
| Respiratory Distress Syndrome, Newborn | Stem Cell Exhaustion | In the PICU, oxygenation index and cancer/hematopoietic stem cell transplant history can be used on acute respiratory distress syndrome day 1 or day 3 to predict hospital mortality without the need for more complex models. | 27487912 |
| Leukemia, Myelocytic, Acute, Acute leukemia | Stem Cell Exhaustion | The impact of HLA-matching on reduced intensity conditioning regimen unrelated donor allogeneic stem cell transplantation for acute myeloid leukemia in patients above 50 years-a report from the EBMT acute leukemia working party. | 27488518 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Data comparing fully matched and mismatched-unrelated-donor (M- and mM-URD) allogeneic hematopoietic stem cell transplant (allo-SCT) following reduced intensity conditioning regimens for acute myeloid leukemia are limited. | 27488518 |
| Non-Small Cell Lung Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | The prognostic value of cancer stem cells (CSCs) marker CD133 in non-small-cell lung cancer (NSCLC) remains controversial. | 27489355 |
| Concomitant Medication Submission Domain, Degenerative polyarthritis | Stem Cell Exhaustion | We have investigated whether the conditioned medium (CM) from adipose-derived mesenchymal stem cells may regulate senescence features induced by inflammatory stress in OA chondrocytes. | 27490266 |
| Refractory angina | Stem Cell Exhaustion | RENEW (Efficacy and Safety of Targeted Intramyocardial Delivery of Auto CD34+ Stem Cells for Improving Exercise Capacity in Subjects With Refractory Angina) was a randomized, double-blind, multicenter trial comparing IM CD34(+) administration with no intervention (open-label standard of care) or IM placebo injections (active control). | 27491607 |
| Refractory angina | Stem Cell Exhaustion | (Efficacy and Safety of Targeted Intramyocardial Delivery of Auto CD34(+) Stem Cells for Improving Exercise Capacity in Subjects With Refractory Angina [RENEW]: NCT01508910). | 27491607 |
| leukemia | Stem Cell Exhaustion | Achieving Molecular Remission before Allogeneic Stem Cell Transplantation in Adult Patients with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Impact on Relapse and Long-Term Outcome. | 27492792 |
| Acute lymphocytic leukemia, BCR gene | Stem Cell Exhaustion | Allogeneic stem cell transplantation (alloHSCT) in first complete remission (CR1) remains the consolidation therapy of choice in Philadelphia-positive (Ph+) acute lymphoblastic leukemia (ALL). | 27492792 |
| Streptococcus viridans, Allogeneic Hematopoietic Stem Cell Transplant Recipient | Stem Cell Exhaustion | Breakthrough viridans streptococcal bacteremia in allogeneic hematopoietic stem cell transplant recipients receiving levofloxacin prophylaxis in a Japanese hospital. | 27495798 |
| T-Cell Large Granular Lymphocyte, Large granular lymphocyte, leukemia | Stem Cell Exhaustion | T-cell large granular lymphocytic (T-LGL) leukemia after hematopoietic stem cell transplantation (SCT) is rare and its natural history and clinical outcome have not been well described. | 27496109 |
| leukemia | Stem Cell Exhaustion | Azacitidine Use After Allogeneic Stem Cell Transplantation-Results From the Polish Adult Leukemia Group. | 27496495 |
| Failure, Hematological Disease | Stem Cell Exhaustion | Relapse of primary hematologic disease constitutes an important reason for failure of allogeneic hematopoietic stem cell transplantation (alloHSCT). | 27496495 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Autologous Hematopoietic Stem Cell Transplantation for Adults With Acute Myeloid Leukemia. | 27496498 |
| Acute leukemia | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (HSCT) remains the most efficacious therapy in patients with acute leukemia. | 27496498 |
| Keratopathy, Corneal leukoma, Keratitis, Fuchs Endothelial Dystrophy, Keratoconus | Stem Cell Exhaustion | The major indications and their respective overall percentage were corneal leucoma (24%), pseudophakic/aphakic bullous keratopathy (22%), Fuchs dystrophy (13%), keratoconus (13%), re-graft (11%), keratitis (9%), and limbal stem cell deficiency (8%), with changes in relative frequency of the leading indications over the following time intervals. | 27496499 |
| Malignant Neoplasms, Hereditary | Stem Cell Exhaustion | Identifying Inherited and Acquired Genetic Factors Involved in Poor Stem Cell Mobilization and Donor-Derived Malignancy. | 27497531 |
| Hematological Disease | Stem Cell Exhaustion | Analysis of the clinical characteristics of hematopoietic stem cell transplant (HSCT) donors has proven beneficial for identifying cases of heritable hematopoietic disorders. | 27497531 |
| Myeloid neoplasm | Stem Cell Exhaustion | This study examines poor peripheral blood hematopoietic stem cell mobilization after granulocyte colony-stimulating factor administration among 328 donors as a potential marker for suspected familial predisposition to myeloid malignancies. | 27497531 |
| Ischemic stroke | Stem Cell Exhaustion | Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study. | 27497862 |
| Dermatomyositis, Polymyositis | Stem Cell Exhaustion | Dysfunction of endothelial progenitor cells is associated with the type I IFN pathway in patients with polymyositis and dermatomyositis. | 27498356 |
| Atrial Fibrillation by ECG Finding | Stem Cell Exhaustion | Reduction of c-kit positive cardiac stem cells in patients with atrial fibrillation. | 27499271 |
| Atrial Fibrillation by ECG Finding | Stem Cell Exhaustion | We aimed to determine expression patterns of cardiac stem cells in the left atrium (LA) tissue from patients with atrial fibrillation. | 27499271 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (HSCT) is potentially curative in a variety of hematological malignancies. | 27502249 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | Accurate determination of recipient cytomegalovirus (CMV) serostatus before allogeneic hematopoietic stem cell transplantation (HSCT) is critical, as it is the most important predictor of post-transplant CMV infection and remains associated with non-relapse mortality. | 27502917 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Phase I study of azacitidine following donor lymphocyte infusion for relapsed acute myeloid leukemia post allogeneic stem cell transplantation. | 27505705 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Donor lymphocyte infusion (DLI) without prophylactic immunosuppression has been used for relapsed AML after allogeneic stem cell transplant (allo-SCT). | 27505705 |
| Limbal stem cell deficiency | Stem Cell Exhaustion | The present study aimed to investigate the clinical outcomes of autologous cultivated oral mucosal epithelial transplantation (COMET) on human amniotic membrane (AM) for corneal limbal stem cell deficiency (LSCD). | 27507558 |
| Adult T-Cell Lymphoma/Leukemia | Stem Cell Exhaustion | Allogeneic hematopoietic stem-cell transplantation (allo-HSCT) is one important treatment option for patients with aggressive adult T-cell leukemia/lymphoma (ATLL). | 27507878 |
| Multiple Myeloma | Stem Cell Exhaustion | The expression of 10 HDACs (including HDAC class I and II) was studied by quantitative reverse transcriptionPCR (qRTPCR) in a cohort of mesenchymal stem cells (MMMSCs) from 10 multiple myeloma patients with a median age 60y. | 27510016 |
| Atherosclerosis | Stem Cell Exhaustion | At baseline, at the end of treatment and six months after atorvastatin withdrawal, disease activity, subclinical atherosclerosis -assessed by measuring carotid-femoral pulse wave velocity (PWV) - and quantification of circulating endothelial progenitor cells (EPC) - as a surrogate biological marker of subclinical atherosclerosis - were carried out. | 27510602 |
| Scleroderma | Stem Cell Exhaustion | Establishment and gene expression analysis of disease-derived induced pluripotent stem cells of scleroderma. | 27510999 |
| Osteoporosis | Stem Cell Exhaustion | KDM5A controls bone morphogenic protein 2-induced osteogenic differentiation of bone mesenchymal stem cells during osteoporosis. | 27512956 |
| JAK2 NP_004963.1:p.V617F, Adenocarcinoma, MYELOPROLIFERATIVE SYNDROME, TRANSIENT | Stem Cell Exhaustion | During her clinical history, she had received an allogeneic, HLA-identical stem cell transplant for myeloproliferative syndrome with a JAK2V617F mutation and lobectomy of the pulmonary right lower lobe for adenocarcinoma. | 27513936 |
| Inflammation, "Alzheimers Disease | Stem Cell Exhaustion | Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer's disease. | 27514990 |
| Up | Stem Cell Exhaustion | Here we have used a human induced pluripotent stem cell (iPSC) model of familial and sporadic AD, in addition to healthy controls, to assess the neuroprotective activity of apigenin. | 27514990 |
| Memory Loss, Up, Cerebral atrophy, "Alzheimers Disease | Stem Cell Exhaustion | Activin A secreted by human mesenchymal stem cells induces neuronal development and neurite outgrowth in an in vitro model of Alzheimer's disease: neurogenesis induced by MSCs via activin A. Alzheimer's disease (AD) is characterized by progressive loss of memory in addition to cortical atrophy. | 27515053 |
| Up | Stem Cell Exhaustion | The aim of this study was to activate the neurogenesis in the SVZ of AD brains by human mesenchymal stem cells (hMSCs). | 27515053 |
| Metabolic Syndrome X, Acute leukemia | Stem Cell Exhaustion | Metabolic syndrome in long-term survivors of childhood acute leukemia treated without hematopoietic stem cell transplantation: an L.E.A. | 27515247 |
| Cardiovascular Diseases, Metabolic Syndrome X | Stem Cell Exhaustion | However, few studies have investigated the risk of metabolic syndrome, a known predictor of cardiovascular disease, in patients treated without hematopoietic stem cell transplantation. | 27515247 |
| Acute leukemia | Stem Cell Exhaustion | (Leucemie de l'Enfant et de l'Adolescent) French cohort of childhood acute leukemia survivors treated without hematopoietic stem cell transplantation. | 27515247 |
| Metabolic Syndrome X, Acute leukemia | Stem Cell Exhaustion | Survivors of childhood acute leukemia are at risk of metabolic syndrome, even when treated without hematopoietic stem cell transplantation or central nervous system irradiation. | 27515247 |
| Neoplasms | Stem Cell Exhaustion | Double immunostaining for CK5/6 and Ki-67 revealed that most of Ki-67-positive proliferating tumor cells were CK5/6-positive, suggesting that CK5/6-positive population contained proliferative progenitor cells of the tumor. | 27516039 |
| Adenolymphoma, Neoplasms, Multinodular oncocytic hyperplasia | Stem Cell Exhaustion | These findings imply that the regional difference in the distribution pattern and proliferative activity of CK5/6-positive putative progenitor cells along with the difference in the pattern of vascular network occurred during the tumorigenic process of the tumor and determined one region to become conventional Warthin's tumor morphology and the other to become nodular oncocytic hyperplasia. | 27516039 |
| T-Cell Prolymphocytic Leukemia | Stem Cell Exhaustion | He had been diagnosed with T-cell prolymphocytic leukemia 4 years earlier and had undergone matched-unrelated-donor stem cell transplant 2 years earlier; on admission, he had relapsed disease. | 27516534 |
| Neoplasms, Multiple Myeloma | Stem Cell Exhaustion | Although several transcriptome analyses of myeloma patient-derived mesenchymal stem cells have displayed differences compared to their healthy counterparts, these analyses insufficiently reflect the signatures mediated by tumor cell contact, vary due to different methodologies, and lack results in lineage-committed precursors. | 27519972 |
| Neoplasms | Stem Cell Exhaustion | To determine tumor cell contact-mediated changes on skeletal precursors, we performed transcriptome analyses of mesenchymal stem cells and osteogenic precursor cells cultured in contact with the myeloma cell line INA-6. | 27519972 |
| Chronic myeloproliferative disorder | Stem Cell Exhaustion | The effects of hematopoietic stem cell transplant on splenic extramedullary hematopoiesis in patients with myeloproliferative neoplasm-associated myelofibrosis. | 27521149 |
| Chronic myeloproliferative disorder | Stem Cell Exhaustion | Hematopoietic stem cell transplant (HSCT) is the only curative treatment for myeloproliferative neoplasm-associated myelofibrosis (MPN-MF). | 27521149 |
| Lymphoma | Stem Cell Exhaustion | The Prognostic Significance of Elevated Serum Ferritin Levels Prior to Transplantation in Patients With Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation (autoHSCT): Role of Iron Overload. | 27521313 |
| Lymphoma | Stem Cell Exhaustion | Hematopoietic stem cell transplantation is a common and preferred treatment of lymphomas in many centers. | 27521313 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Comparative Outcomes after Haploidentical or Unrelated Donor Bone Marrow or Blood Stem Cell Transplantation in Adult Patients with Hematological Malignancies. | 27522040 |
| Primary Myelofibrosis, PMF Regimen | Stem Cell Exhaustion | A combination of low-dose thalidomide and corticosteroids is a treatment option for anaemic patients with primary myelofibrosis (PMF) who are not eligible for allogeneic hematopoietic stem cell transplantation. | 27526305 |
| Specialty Type - cancer | Stem Cell Exhaustion | IVE might express a cancer stem cell (CSC) phenotype. | 27528226 |
| Adult Glioblastoma | Stem Cell Exhaustion | Sox2, a stemness gene, regulates tumor-initiating and drug-resistant properties in CD133-positive glioblastoma stem cells. | 27530866 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | These cancer stem cells (CSCs) promote the potency of tumor initiation. | 27530866 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | As a result, targeting of glioma stem cells has become the dominant way of improving the therapeutic outcome against GBM and extending the life span of patients. | 27530866 |
| Toxoplasmosis | Stem Cell Exhaustion | Clinical characteristics and computed tomography findings of pulmonary toxoplasmosis after hematopoietic stem cell transplantation. | 27531150 |
| Toxoplasmosis | Stem Cell Exhaustion | The prognosis of pulmonary toxoplasmosis, including disseminated toxoplasmosis involving the lungs, following hematopoietic stem cell transplantation (HSCT) is extremely poor due to the difficulties associated with early diagnosis and the rapidly progressive deterioration of multiorgan function. | 27531150 |
| Adult Glioblastoma | Stem Cell Exhaustion | Sensitivity to PRIMA-1MET is associated with decreased MGMT in human glioblastoma cells and glioblastoma stem cells irrespective of p53 status. | 27533246 |
| leukemia, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | We report a clinical observation of TKIs cessation in Chinese CML patients and a probable connection between CML leukemia stem cells (LSCs) and relapse. | 27533462 |
| Adenoma | Stem Cell Exhaustion | Our findings showed the existence of cells that are phenotypically intermediate between ganglion cells and adenoma cells, and the existence of stem cell-like cells, which support the hypothesis that adenoma cells can transform into ganglion cells or that both ganglion and adenoma cells derive from common stem cells. | 27535625 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | The cumulative incidence of neutrophil and platelet engraftment of the study cohort was compared to that of a cohort of 95 allogeneic peripheral blood stem cell transplant recipients treated during the same period of time and who received similar conditioning and graft-versus-host disease prophylaxis. | 27535663 |
| Neuroendocrine Tumors, Paraganglioma, Adrenal Gland Pheochromocytoma, SDHD wt Allele | Stem Cell Exhaustion | Pheochromocytomas (PCC) and paragangliomas (PGL) are neuroendocrine tumours arising from pluripotent neural crest stem cells and are associated with neurons of the autonomic nervous system. | 27535829 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | An operational definition of primary refractory acute myeloid leukemia allowing early identification of patients who may benefit from allogeneic stem cell transplantation. | 27540133 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Furthermore, these data demonstrate that allogeneic stem cell transplantation represents an effective therapeutic modality in selected patients with primary refractory acute myeloid leukemia. | 27540133 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Our aim was to improve outcome prediction after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia by combining cytogenetic and molecular data at diagnosis with minimal residual disease assessment by multicolor flow-cytometry at transplantation. | 27540139 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Assessment of minimal residual disease at transplantation in combination with cytogenetic and molecular findings provides powerful independent prognostic information in acute myeloid leukemia, lending support to the incorporation of minimal residual disease detection to refine risk stratification and develop a more individualized approach during hematopoietic stem cell transplantation. | 27540139 |
| Specialty Type - cancer | Stem Cell Exhaustion | The current treatment regimens are ineffective against the small population of cancer stem cells residing in the tumourigenic niche; however, a new therapeutic approach could involve the removal of these cells from the microenvironment that maintains the cancer stem cell phenotype. | 27541285 |
| Specialty Type - cancer | Stem Cell Exhaustion | GSCs adherence on fibronectin is mediated by a5b1 integrin, where fibronectin further promotes GSC migration and is an effective candidate for in vivo cancer stem cell migration out of the tumourigenic niche. | 27541285 |
| Specialty Type - cancer | Stem Cell Exhaustion | Our results suggest that therapies against ADAM10 and ADAM17 may promote cancer stem cell migration away from the tumourigenic niche resulting in a differentiated phenotype that is more susceptible to treatment. | 27541285 |
| Avascular necrosis, tacrine, Avascular Necrosis, CTCAE, Degenerative polyarthritis | Stem Cell Exhaustion | As patients who receive hematopoietic stem cell transplantation are at increased risk of avascular necrosis (AVN) and subsequent degenerative arthritis, THA may be considered in some of these patients, particularly as overall patient survival improves for patients undergoing stem-cell transplants. | 27542147 |
| GDC Comorbidity Terminology, Communicable Diseases | Stem Cell Exhaustion | Patients receiving hematopoietic stem cell transplantation theoretically are at increased risk of experiencing complications, infection, and poorer implant survivorship owing to the high prevalence of comorbid conditions, immunosuppressive therapy regimens including corticosteroids, and often low circulating hematopoietic cell lines; however, there is a paucity of studies elucidating these risks. | 27542147 |
| Disease, Lymphoma, Amyloidosis, leukemia, primary disorders | Stem Cell Exhaustion | Underlying primary diseases leading to hematopoietic stem cell transplantation included lymphoma (14/42; 33%), plasma cell disorders (10/42; 24%), leukemia (9/42; 21%), and amyloidosis (3/42; 7%). | 27542147 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Antineoplastic effects and mechanisms of micheliolide in acute myelogenous leukemia stem cells. | 27542251 |
| leukemia | Stem Cell Exhaustion | Leukemic stem cells (LSCs) greatly contribute to the initiation, relapse, and multidrug resistance of leukemia. | 27542251 |
| Limbal stem cell deficiency | Stem Cell Exhaustion | This study addresses important issues regarding possible risks associated with disarray of the ocular surface homeostasis following autologous CLET in patients with limbal stem cell deficiency, despite the fact that the majority of patients experienced a favourable long-term benefit. | 27543289 |
| Fibrosis, Liver | Stem Cell Exhaustion | HuR mediates motility of human bone marrow-derived mesenchymal stem cells triggered by sphingosine 1-phosphate in liver fibrosis. | 27543493 |
| fibrogenesis | Stem Cell Exhaustion | Sphingosine 1-phosphate (S1P) participates in migration of bone marrow (BM)-derived mesenchymal stem cells (BMSCs) toward damaged liver via upregulation of S1P receptor 3 (S1PR3) during mouse liver fibrogenesis. | 27543493 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease (GVHD) remains a major problem of allogeneic hematopoietic-stem cell transplantation (HSCT) and an obstacle for successful outcome. | 27546540 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | We compared overall survival (OS) of 1017 patients with newly diagnosed multiple myeloma (MM) who were treated with different novel agent-based induction regimens and who underwent early autologous stem cell transplant (ASCT). | 27548464 |
| Aplastic Anemia | Stem Cell Exhaustion | The Latin American experience of allografting patients with severe aplastic anaemia: real-world data on the impact of stem cell source and ATG administration in HLA-identical sibling transplants. | 27548465 |
| melanoma, Neoplasms | Stem Cell Exhaustion | Ipi-Bev also augmented humoral immune responses recognizing targets in melanoma, tumor endothelial, and tumor mesenchymal stem cells. | 27549123 |
| Carcinogenic Chlorinated Hydrocarbon, Hollings Cancer Center | Stem Cell Exhaustion | Consistent with this finding, immunohistochemical analysis revealed that hepatocyte markers (Hep Par 1 and GPC3) and cholangiocyte markers (CK7 and CK19) were simultaneously expressed in both the HCC and ICC components in 52.9% of CHC specimens, suggesting that the two components shared a similar phenotype with hepatic progenitor cells (HPCs). | 27552844 |
| Malignant neoplasm of stomach, Specialty Type - cancer | Stem Cell Exhaustion | Clinical significance of putative markers of cancer stem cells in gastric cancer: A retrospective cohort study. | 27557490 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cells (CSCs) are thought as the source of tumor maintaining and many CSCs markers have been identified. | 27557490 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | RhoGDIa suppresses self-renewal and tumorigenesis of glioma stem cells. | 27557508 |
| Glioblastoma Multiforme Pathway, Neoplasms | Stem Cell Exhaustion | Glioma stem cells (GSCs) are a subset of tumor cells that drive glioma initiation and progression. | 27557508 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | RhoGDIa was down-regulated in glioma stem cells. | 27557508 |
| Respiratory Failure | Stem Cell Exhaustion | Respiratory Failure in a Woman 8 Months After an Allogeneic Stem Cell Transplant. | 27559706 |
| Corneal Endothelial Cell Loss | Stem Cell Exhaustion | Although rare, circulating endothelial and progenitor cells could be considered as markers of endothelial damage and repair potential, possibly predicting the severity of cardiovascular manifestations. | 27560136 |
| Ectopic calcification, "cytidylyl-(3-5)-cytidine | Stem Cell Exhaustion | Circulating mature cells (CMC, CD45-, CD34+, CD133-) and circulating progenitor cells (CPC, CD45dim, CD34bright, CD133+) were investigated by polychromatic high-speed flow cytometry to detect the expression of endothelial (CD309+) or osteogenic (BAP+) differentiation markers in healthy subjects and in patients affected by peripheral vascular manifestations associated with ectopic calcification. | 27560136 |
| Hemopoietic stem cell transplant | Stem Cell Exhaustion | Moreover, the patients with >10^-4 MRD level before the start of HSCT (hematopoietic stem cell transplantation) had worse prognosis and higher risk of relapse compared to patients with <=10^-4 before the start of HSCT. | 27561414 |
| Lymphoma | Stem Cell Exhaustion | Relapse risk after autologous stem cell transplantation in patients with lymphoma based on CD34+ cell dose. | 27561733 |
| Carcinogenesis | Stem Cell Exhaustion | Canonical Wnt/b-catenin signalling is essential for maintaining intestinal stem cells, and its constitutive activation has been implicated in colorectal carcinogenesis. | 27562646 |
| Colorectal Carcinoma | Stem Cell Exhaustion | TNIK is required for the tumour-initiating function of colorectal cancer stem cells. | 27562646 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Preclinical investigation of ibrutinib, a Bruton's kinase tyrosine (Btk) inhibitor, in suppressing glioma tumorigenesis and stem cell phenotypes. | 27564106 |
| Acute GVH disease | Stem Cell Exhaustion | This secondary analysis of a large, multicenter Blood and Marrow Transplant Clinical Trials Network randomized trial assessed whether patient-reported outcomes (PROs) and socioeconomic status (SES) before hematopoietic stem cell transplantation (HCT) are associated with each other and predictive of clinical outcomes, including time to hematopoietic recovery, acute graft-versus-host disease, hospitalization days, and overall survival (OS) among 646 allogeneic and autologous HCT recipients. | 27565521 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: multicenter randomized controlled clinical trial (phase I/II). | 27565858 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplantation (AuHSCT) is standard in treating eligible multiple myeloma (MM) patients. | 27566569 |
| Specialty Type - cancer, Gastritis | Stem Cell Exhaustion | In this study, we report the significance of an elevation of the stem cell regulator SOX9 in bacteria-infected human gastritis and cancer samples, paralleling increased levels of TNFa SOX9 elevation was more intense in specimens containing the pathogenically significant cagA+ strains of H. pylori Notably, we found that SOX9 was required for bacteria-induced gastric cancer cell proliferation, increased levels of b-catenin, and acquisition of stem cell-like properties. | 27569216 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | The patient, a 52-year-old woman, received chemotherapy and autologous peripheral blood stem cell transplantation for relapsed diffuse large B-cell lymphoma (DLBCL). | 27569297 |
| Lymphoma, Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | This was the first case of EBVMCU characterized by both an association with autologous peripheral blood stem cell transplantation and subsequent emergence of malignant lymphoma in a patient with relapsed DLBCL. | 27569297 |
| leukemia | Stem Cell Exhaustion | RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML. | 27570067 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Age-related human hematopoietic stem cell (HSC) exhaustion and myeloid-lineage skewing promote oncogenic transformation of hematopoietic progenitor cells into therapy-resistant leukemia stem cells (LSCs) in secondary acute myeloid leukemia (AML). | 27570067 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Comprehensive RNA sequencing and splice-isoform-specific PCR uncovered characteristic RNA splice isoform expression patterns that distinguished normal young and aged human stem and progenitor cells (HSPCs) from malignant myelodysplastic syndrome (MDS) and AML progenitors. | 27570067 |
| Multiple Myeloma | Stem Cell Exhaustion | Treatment response evaluation with 18F-FDG PET/CT and 18F-NaF PET/CT in multiple myeloma patients undergoing high-dose chemotherapy and autologous stem cell transplantation. | 27573638 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | The aim of this study was to assess the combined use of the radiotracers 18F-FDG and 18F-NaF in treatment response evaluation of a group of multiple myeloma (MM) patients undergoing high-dose chemotherapy (HDT) followed by autologous stem cell transplantation (ASCT) by means of static (whole-body) and dynamic PET/CT (dPET/CT). | 27573638 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | In this context, pretransplant treatment with MOG may induce severe graft-versus-host disease (GVHD) in allogeneic hematopoietic stem-cell transplantation (HSCT). | 27573760 |
| Burn injury | Stem Cell Exhaustion | As part of the strategies for the management of severe cases, there is an ongoing research and development protocol on 'Translational Clinical Trial phases I/II to evaluate the safety and efficacy of adult mesenchymal stem cells from bone marrow for the treatment of large burns and radiological lesions'. | 27574323 |
| Hepatic Veno-Occlusive Disease | Stem Cell Exhaustion | Hepatic veno-occlusive disease, also called sinusoidal obstruction syndrome (VOD/SOS), is an unpredictable, potentially life-threatening complication of hematopoietic stem cell transplant conditioning. | 27574402 |
| Lymphoma | Stem Cell Exhaustion | Phase II Study of Propylene Glycol-Free Melphalan Combined with Carmustine, Etoposide, and Cytarabine for Myeloablative Conditioning in Lymphoma Patients Undergoing Autologous Stem Cell Transplantation. | 27575541 |
| Lymphoma | Stem Cell Exhaustion | These results demonstrate that PG-free melphalan can be used in place of the standard, lyophilized formulation of melphalan in the BEAM regimen for lymphoma patients undergoing autologous stem cell transplantation. | 27575541 |
| Thalassemia | Stem Cell Exhaustion | One-year results from a prospective randomized trial comparing phlebotomy with deferasirox for the treatment of iron overload in pediatric patients with thalassemia major following curative stem cell transplantation. | 27576370 |
| Hypernatremia, Thalassemia | Stem Cell Exhaustion | Iron overload is well documented in patients with b-thalassemia major, and patients who have undergone hematopoietic stem cell transplantation (HSCT) remain at risk as a result of pre- and immediate post-HSCT transfusions. | 27576370 |
| methyldopa | Stem Cell Exhaustion | We found that interactions between SNPs with highest AMD association were epigenetically active in the liver, adipocytes, and mesenchymal stem cells. | 27576376 |
| Evans syndrome, Hodgkin Disease | Stem Cell Exhaustion | Evans syndrome after autologous peripheral blood stem cell transplantation for recurrent Hodgkin lymphoma. | 27577012 |
| Evans syndrome, Hodgkin Disease | Stem Cell Exhaustion | We describe a rare case of Evans syndrome (ES) that developed in a 16-year-old patient >1 year after autologous peripheral blood stem cell transplantation for recurrent Hodgkin lymphoma. | 27577012 |
| Specialty Type - cancer | Stem Cell Exhaustion | Gender, cancer diagnosis, radiation therapy, anthracycline exposure, and hematopoietic stem cell transplant were not significantly associated with adherence. | 27578608 |
| Amyloidosis | Stem Cell Exhaustion | Combination therapy with high-dose melphalan and autologous stem cell transplantation was performed according to the regimen for AL amyloidosis. | 27580556 |
| Cancer/Testis Antigen | Stem Cell Exhaustion | The expression of cancer testis antigen MAGE C1 has been linked to the malignant stem cell in this disease, and thus, we investigated the use of both flow cytometric and qRTPCR approaches to monitor its expression as an alternative monitoring methodology in this pilot study. | 27581737 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer testis antigen MAGE C1 can be used to monitor levels of circulating malignant stem cells in the peripheral blood of multiple myeloma patients. | 27581737 |
| Multiple Myeloma | Stem Cell Exhaustion | Evaluation of in vitro effects of various targeted drugs on plasma cells and putative neoplastic stem cells in patients with multiple myeloma. | 27582537 |
| Fever, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Skin Lesions and Recurrent Fever in Acute Myeloid Leukemia Patient Treated With Allogeneic Stem Cell Transplant. | 27583691 |
| Social security number, Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cell markers are not much explored in the cases of OSSN. | 27584160 |
| Social security number | Stem Cell Exhaustion | In the present study, we aim to evaluate the expression of stem cells using stem cell markers mainly p63, ABCG2, c-KIT (CD117) and CD44 in OSSN tissue, which could have prognostic significance. | 27584160 |
| Specialty Type - cancer, Neoplasms, CDISC SDTM Lesion Complexity Terminology | Stem Cell Exhaustion | Recent findings on cancer stem cells theory indicate that population of stem-like cell as in neoplasia determines its heterogeneity and complexity leading to varying tumor development of metastatic behavior and recurrence. | 27584160 |
| Social security number | Stem Cell Exhaustion | Our results show for the first time that these four stem cells especially the limbal epithelium stem cells play a vital role in the genesis of OSSN but we need to explore more cases before establishing its clinical and biological significance. | 27584160 |
| Multiple Myeloma | Stem Cell Exhaustion | Outcome with lenalidomide plus dexamethasone followed by early autologous stem cell transplantation in patients with newly diagnosed multiple myeloma on the ECOG-ACRIN E4A03 randomized clinical trial: long-term follow-up. | 27588519 |
| Multiple Myeloma | Stem Cell Exhaustion | In Eastern Cooperative Oncology Group-ACRIN E4A03, on completion of four cycles of therapy, newly diagnosed multiple myeloma patients had the option of proceeding to autologous peripheral blood stem cell transplant (ASCT) or continuing on their assigned therapy lenalidomide plus low-dose dexamethasone (Ld) or lenalidomide plus high-dose dexamethasone (LD). | 27588519 |
| Neoplasms | Stem Cell Exhaustion | Within GBM exists a subpopulation of cells, glioblastoma-initiating cells (GIC), which possess the characteristics of progenitor cells, have the ability to initiate tumour growth and resist to current treatment strategies. | 27589691 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Matched and mismatched unrelated donor compared to autologous stem cell transplantation for acute myeloid leukemia in first complete remission: a retrospective, propensity score-weighted analysis from the ALWP of the EBMT. | 27589849 |
| Neoplasms | Stem Cell Exhaustion | The current study was planned to gain insight into its molecular genetics using a targeted next-generation sequencing approach and to explore the status of epithelial-mesenchymal transition (EMT)-associated markers (E-/P-/N-cadherins, MMP-2/-9 and caveolin-1), downstream transcriptional regulators of EMT-related signaling pathways (ZEB-1/-2, Slug), stem cell factors (Oct3/4, LIN28, SOX2, SO17, NANOG, CD133, nestin), and markers of adrenocortical origin/tumorigenesis (SF-1, b-catenin, p53) in phenotypically diverse tumor components of 6 cases. | 27589897 |
| Neoplasms | Stem Cell Exhaustion | These tumors are enriched for EMT-related markers and stem cell factors, potentially conferring a poor prognosis, which might be exploited as novel therapeutic targets. | 27589897 |
| Multiple Myeloma | Stem Cell Exhaustion | Escalating doses of bortezomib with high-dose melphalan was evaluated as as a conditioning regimen for autologous stem cell transplantation (ASCT) in patients with relapsed or refractory multiple myeloma (MM). | 27590107 |
| Pathology | Stem Cell Exhaustion | Cell replacement and regenerative therapy using embryonic stem cell-derived material holds promise for the treatment of several pathologies. | 27590276 |
| Experimental Organism Basal Cell Carcinoma, Malignant Neoplasms, Squamous cell carcinoma | Stem Cell Exhaustion | Evidence suggests that progenitor cells of keratinocyte cancers (basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)) may originate from epidermal stem cells including hair follicle stem cells. | 27590883 |
| Neoplasms | Stem Cell Exhaustion | Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) is a putative intestinal stem cell marker that is also expressed in various tumors. | 27593551 |
| Stomach Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | In intramucosal SRCC, the low mitotic activity of Lgr5-positive cells suggests that they may represent cancer stem cells as seen in other types of stomach carcinomas. | 27593551 |
| AIDS-Related Hodgkin Lymphoma | Stem Cell Exhaustion | Outcomes of autologous stem cell transplantation (ASCT) in patients with relapsed/refractory HIV-associated lymphoma. | 27595283 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | This study investigated the long-term effect of adding bendamustine to a conditioning regimen on survival, rate of engraftment, immune recovery and GvHD after allogeneic stem cell transplantation (alloSCT) in CLL patients. | 27595282 |
| Acute leukemia | Stem Cell Exhaustion | Prevalence and risk factors of iron overload after hematopoietic stem cell transplantation for childhood acute leukemia: a LEA study. | 27595286 |
| Myeloid neoplasm | Stem Cell Exhaustion | Reduced-intensity conditioning (RIC) has been shown to have similar overall survival (OS) but higher relapse rates compared with myeloablative (MAC) regimens in patients with myeloid malignancies undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 27596129 |
| Primary Myelofibrosis | Stem Cell Exhaustion | Outcome of Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Chronic and Advanced Phase Myelofibrosis. | 27596130 |
| Coronary microvascular dysfunction | Stem Cell Exhaustion | Circulating progenitor cells and coronary microvascular dysfunction: Results from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation - Coronary Vascular Dysfunction Study (WISE-CVD). | 27596135 |
| Ischemia | Stem Cell Exhaustion | Ischemia stimulates a reparative response resulting in mobilization of circulating progenitor cells (CPCs). | 27596135 |
| Specialty Type - cancer | Stem Cell Exhaustion | We then evaluated the expression levels of epithelial-mesenchymal transition (EMT)-related molecules (E-cadherin, S100A4), invasion-related molecules (laminin-5, ezrin), stem-cell-related molecules (ALDH-1), and growth factor receptors (c-Met, EGFR) in cancer cells of each group (n=20). | 27597281 |
| Intestinal Motility, Dominica, Diabetes Mellitus, Microcirculation disorders, Inflammation | Stem Cell Exhaustion | Clinical and experimental research has revealed that diabetes mellitus (DM) is characterized by intestinal hypomotility, gut microbial dysbiosis, increased gut permeability, microcirculation disorders, circulatory changes, and dysfunction of intestinal stem cells, which may be linked to inflammation of intestinal mucosa. | 27598308 |
| Epithelioma | Stem Cell Exhaustion | CD44, a major surface receptor for hyaluronic acid, has multiple isoforms and represents a major cancer stem cell marker for various epithelial tumors. | 27599396 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Posaconazole Tablet Formulation at 400 Milligrams Daily Achieves Desired Minimum Serum Concentrations in Adult Patients with a Hematologic Malignancy or Stem Cell Transplant. | 27600035 |
| Hematologic Neoplasms, Mycoses | Stem Cell Exhaustion | We describe our experience using the posaconazole 400-mg delayed-release tablet formulation once daily in 20 patients with hematologic malignancy or hematopoietic stem cell transplant who were unable to attain prespecified target minimum serum (trough) concentrations for treatment or prophylaxis of invasive fungal infection. | 27600035 |
| Diabetes | Stem Cell Exhaustion | The present work investigates whether and by which mechanism diabetes negatively impacts on functional properties of muscular pericytes (MPs), which are resident stem cells committed to reparative angiomyogenesis. | 27600065 |
| Malignant neoplasm of stomach, Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | Recent progress in gastric cancer research has demonstrated the crucial roles of cancer stem cells (CSCs) in the development, metastasis, and drug resistance of this disease. | 27602437 |
| Lymphocyte Culture Test, Mixed, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | To enlighten interactions between autologous, allogeneic or T-cells from patients after stem cell transplantation with leukaemia-derived-dendritic-cells containing dendritic cells or blast containing mononuclear cells (n = 21, respectively), we determined cytokine-concentrations (interleukin 2, 4, 6, 10, tumor-necrosis-factor-a, interferon-g) in supernatants of mixed-lymphocyte-culture and in serum (n = 16) of 20 patients with acute myeloid leukaemia and three patients with myelodysplastic syndromes by cytometric-bead-assay. | 27602789 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Leukemia stem cells (LSC) are responsible for the initiation and maintenance of AML due to their stem-cell properties. | 27604463 |
| Anemia | Stem Cell Exhaustion | Sf3b1K700E/+ animals had impaired erythropoiesis and progressive anemia without ringed sideroblasts, as well as reduced hematopoietic stem cell numbers and host-repopulating fitness. | 27604819 |
| Cryptorchidism, Stem Cell Factor | Stem Cell Exhaustion | Materials and Methods Histology sections from 373 testicular biopsies from 289 boys aged 1 month to 2 years operated for cryptorchidism were incubated with primary antibodies including anti-placental-like-alkaline phosphatase, antiOct-3/4, anti-C-kit, anti-D2-40, and in case of repeat biopsy with anti-stem cell factor (SCF) receptor. | 27606906 |
| Cerebrovascular accident | Stem Cell Exhaustion | Granulocyte Colony Stimulating Factor and Physiotherapy after Stroke: Results of a Feasibility Randomised Controlled Trial: Stem Cell Trial of Recovery EnhanceMent after Stroke-3 (STEMS-3 ISRCTN16714730). | 27610616 |
| Cerebrovascular accident | Stem Cell Exhaustion | Granulocyte-colony stimulating factor (G-CSF) mobilises endogenous haematopoietic stem cells and enhances recovery in experimental stroke. | 27610616 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | Cytomegalovirus Infection and Treatment in Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective Study from a Single Institution in an Endemic Area. | 27610628 |
| Failure, Communicable Diseases | Stem Cell Exhaustion | Although Cytomegalovirus (CMV) infection is a major complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT), the risk factors for CMV reactivation and treatment failure in CMV endemic areas have remained unclear. | 27610628 |
| leukemia | Stem Cell Exhaustion | Aldehyde dehydrogenases inhibition eradicates leukemia stem cells while sparing normal progenitors. | 27611922 |
| Specialty Type - cancer, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Unravelling the relevance of CLEC12A as a cancer stem cell marker in myelodysplastic syndrome. | 27612176 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | Due to the absence of CLEC12A on normal haematopoietic stem cells, CLEC12A stem cell immunophenotyping may contribute to diagnosing and monitoring MDS patients and could furthermore add knowledge about disease propagating cells in MDS. | 27612176 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Evidence of distinct disease propagating stem cells in myelodysplastic syndrome (MDS) has emerged in recent years. | 27612176 |
| Specialty Type - cancer | Stem Cell Exhaustion | However, immunophenotypic characterization of these cancer stem cells remains sparse. | 27612176 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Furthermore, CLEC12A has been proposed as a promising marker of leukaemic stem cells in AML. | 27612176 |
| PAFAH1B1 wt Allele, Specialty Type - cancer, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | As opposed to reported findings in AML, we showed that cancer stem cells from MDS samples derived from both CLEC12A positive and negative CD34+ CD38- subpopulations. | 27612176 |
| Atherosclerosis, Hypoxia | Stem Cell Exhaustion | Adipose-derived mesenchymal stem cells from patients with atherosclerotic renovascular disease have increased DNA damage and reduced angiogenesis that can be modified by hypoxia. | 27612459 |
| CLU protein, human, Ischemia | Stem Cell Exhaustion | DM was highly prevalent in two recently conducted randomized controlled trials in CLI patients, the PADI (Percutaneous Transluminal Balloon Angioplasty [PTA] and Drug Eluting Stents for Infrapopliteal Lesions in Critical Limb Ischemia) and JUVENTAS (Rejuvenating Endothelial Progenitor Cells via Transcutaneous Intra-Arterial Supplementation) trials. | 27612499 |
| Multiple Myeloma | Stem Cell Exhaustion | Upfront autologous stem cell transplantation for newly diagnosed elderly multiple myeloma patients: a prospective multicenter study. | 27612987 |
| Multiple Myeloma | Stem Cell Exhaustion | The feasibility and efficacy of high-dose melphalan followed by autologous hematopoietic stem cell transplantation in newly diagnosed elderly patients with multiple myeloma was analyzed prospectively. | 27612987 |
| Multiple Myeloma | Stem Cell Exhaustion | This prospective study provides evidence for the safety and efficacy of autologous hematopoietic stem cell transplantation as a first-line treatment approach in elderly multiple myeloma patients. | 27612987 |
| Specialty Type - cancer, Thrombomodulin Alfa | Stem Cell Exhaustion | Immunohistochemical results from clinical tissue microarray (TMA) suggested that the expression concordance rates of cancer stem cells (CSCs) and drug resistance relative proteins between lymph-node metastatic and primary CRC foci were low. | 27613840 |
| Lymphoma | Stem Cell Exhaustion | Prospective noninterventional study on peripheral blood stem cell mobilization in patients with relapsed lymphomas. | 27614935 |
| Lymphoma | Stem Cell Exhaustion | High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) to rescue hematopoiesis is considered standard care for patients with a relapsed chemosensitive lymphoma, but diagnosis of lymphoma has been a risk factor for poor mobilization in several studies. | 27614935 |
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Stem Cell Exhaustion | Multi-center analysis of the effect of T-cell acute lymphoblastic leukemia subtype and minimal residual disease on allogeneic stem cell transplantation outcomes. | 27618682 |
| Adult T-Cell Lymphoma/Leukemia, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Stem Cell Exhaustion | This study aims to provide a detailed analysis of allogeneic stem cell transplantation (allo-SCT) outcomes in a large T-cell acute lymphoblastic leukemia (T-ALL) cohort with a specific emphasis on the effects of pre-transplant minimal residual disease (MRD) and disease subtype, including the aggressive early-thymic precursor (ETP) subtype. | 27618682 |
| Specialty Type - cancer, Squamous cell carcinoma of the head and neck | Stem Cell Exhaustion | Identification, expansion and characterization of cancer cells with stem cell properties from head and neck squamous cell carcinomas. | 27619333 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Recent data indicate the presence of cancer stem cells (CSC) in many solid tumors, including HNSCC. | 27619333 |
| Graft-vs-Host Disease, Anteroventral Thalamic Nucleus | Stem Cell Exhaustion | NV (59%), RV (74%) and AV (78%) were identified in hematopoietic stem cell transplant (HSCT) recipients; and in patients with graft versus host disease (GVHD): NV (34%), RV (46%) and AV (57%). | 27620005 |
| Stomach Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma. | 27620279 |
| Stomach Carcinoma, Specialty Type - cancer, Neoplasms, Primary Neoplasm | Stem Cell Exhaustion | This study aimed to characterize biomarkers allowing the detection of cancer stem cells (CSC) in human gastric carcinoma of different histologic types.Experimental Design: The primary tumors from 37 patients with intestinal- or diffuse-type noncardia gastric carcinoma were studied, and patient-derived tumor xenograft (PDX) models in immunodeficient mice were developed. | 27620279 |
| Alzheimers Disease | Stem Cell Exhaustion | Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes. | 27622770 |
| Up | Stem Cell Exhaustion | The advent of induced pluripotent stem cells (iPSCs) allows us to model pathology and study disease mechanisms directly in human neural cells from healthy individual as well as AD patients. | 27622770 |
| Up | Stem Cell Exhaustion | We report brain organoids that use pluripotent stem cells derived from AD patients and recapitulate AD-like pathologies such as amyloid aggregation, hyperphosphorylated tau protein, and endosome abnormalities. | 27622770 |
| MS gene | Stem Cell Exhaustion | In a group of 19 consecutive patients with multiple sclerosis given autografts, we employed granulocyte colony-stimulating factors to mobilize stem cells from the bone marrow to the peripheral blood, either the original granulocyte colony-stimulating factor (n = 10) or a Mexican granulocyte colony-stimulating factor biosimilar (n = 9). | 27623036 |
| leukemia | Stem Cell Exhaustion | The Total Body Irradiation Schedule Affects Acute Leukemia Relapse After Matched T Cell-Depleted Hematopoietic Stem Cell Transplantation. | 27623308 |
| Acute leukemia | Stem Cell Exhaustion | We sought to determine whether the total body irradiation (TBI) schedule affected outcome in patients with acute leukemia in complete remission who received T cell-depleted allogeneic hematopoietic stem cell transplantation from HLA identical siblings. | 27623308 |
| Acute leukemia | Stem Cell Exhaustion | In patients with acute leukemia, HTBI is more efficacious than STBI in eradicating minimal residual disease after HLA-matched T cell-depleted hematopoietic stem cell transplantation, thus affecting DFS. | 27623308 |
| Specialty Type - cancer | Stem Cell Exhaustion | Moreover, CST-Abl expression enabled 4T1 cells to persist innocuously in the mammary glands of mice, doing so by exhausting their supply of cancer stem cells. | 27626309 |
| Acanthamoeba, Sinusitis | Stem Cell Exhaustion | Successful Treatment of Sinusitis by Acanthamoeba in a Pediatric Patient After Allogeneic Stem Cell Transplantation. | 27626919 |
| Hematoma | Stem Cell Exhaustion | The early human fracture hematoma is characterized by maturation of granulocytes and migration of monocytes/macrophages and hematopoietic stem cells. | 27629117 |
| Disease, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Cytopenia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell disorders characterized by ineffective hematopoiesis, cytopenias and a risk of progression to acute myeloid leukemia (AML). | 27629836 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft versus host disease (GVHD) is an important complication of peripheral blood stem cell transplantation. | 27631185 |
| Specialty Type - cancer | Stem Cell Exhaustion | Finally, we describe the TBX3-dependency of cancer stem cells that perpetuate themselves through an autocrine TBX3-ACTIVIN/NODAL signalling loop to sustain stemness. | 27632063 |
| Encephalitis, Opportunistic Infections | Stem Cell Exhaustion | An emerging opportunistic infection: fatal astrovirus (VA1/HMO-C) encephalitis in a pediatric stem cell transplant recipient. | 27632248 |
| Osteoporotic Fractures | Stem Cell Exhaustion | Real-Time H2 O2 Measurements in Bone Marrow Mesenchymal Stem Cells (MSCs) Show Increased Antioxidant Capacity in Cells From Osteoporotic Women. | 27632788 |
| Osteoporosis, Postmenopausal, Cocaine-Related Disorders | Stem Cell Exhaustion | It has also been associated with several age-related disorders, like postmenopausal osteoporosis of Mesenchymal stem cells (MSCs). | 27632788 |
| Malignant Neoplasms | Stem Cell Exhaustion | High-dose therapy and autologous stem cell transplantation in patients with POEMS syndrome: a retrospective study of the Plasma Cell Disorder sub-committee of the Chronic Malignancy Working Party of the European Society for Blood & Marrow Transplantation. | 27634201 |
| Engraftment syndrome | Stem Cell Exhaustion | Engraftment was seen in 97% patients and engraftment syndrome was documented in 23% of autologous stem cell transplantation recipients. | 27634201 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | This analysis reports on 72 patients with relapsed or refractory non-Hodgkin lymphoma who were treated with R-DHAP salvage chemotherapy regimen followed by high-dose chemotherapy and stem cell transplantation. | 27635469 |
| Stargardts disease", methyldopa | Stem Cell Exhaustion | This paper describes some of the recent advances in the use of human stem cells, particularly those made in the area of ophthalmology, and more specifically, in Stargardt's disease and age-related macular degeneration (AMD). | 27637197 |
| Disease, Retinal Pigments | Stem Cell Exhaustion | We also present promising studies with induced pluripotent stem cells (iPS), aimed at obtaining retinal pigmented epithelium and light-sensitive retinal rods in the aforementioned ocular diseases, with encouraging preclinical and clinical results. | 27637197 |
| Neoplasms | Stem Cell Exhaustion | From a medical point of view, we must not forget that the transplanted retinal epithelium cells may cause tumours, since they have been obtained from Embryonic Stem cells, and may trigger immune rejection problems since they are heterologous. | 27637197 |
| Globoid cell leukodystrophy | Stem Cell Exhaustion | Hematopoietic Stem cell transplantation and lentiviral vector-based gene therapy for Krabbe's disease: Present convictions and future prospects. | 27638600 |
| Central Nervous System, Globoid cell leukodystrophy | Stem Cell Exhaustion | Currently, presymtomatic hematopoietic stem and progenitor cell transplantation (HSPCT) is the only therapeutic modality that alleviates Krabbe's disease (KD)-induced central nervous system damage. | 27638600 |
| Malignant neoplasm of kidney, Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | Reduced expression of CXCR4, a novel renal cancer stem cell marker, is associated with high-grade renal cell carcinoma. | 27638770 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells (CSCs) represent a population with tumour-initiating, self-renewal, and differentiation potential. | 27638770 |
| SLC25A20 gene | Stem Cell Exhaustion | In univariate analysis, those positive for tissue factor, ICAM-1, stem cells, and adipocytes (P16-set) antigens associated with CAC in the PE group. | 27639028 |
| Hepatobiliary System, Bile duct structure | Stem Cell Exhaustion | Biliary-committed progenitor cells (small mouse cholangiocytes; SMCCs) from small bile ducts are more resistant to hepatobiliary injury than large mouse cholangiocytes (LGCCs) from large bile ducts. | 27639079 |
| Injury of liver | Stem Cell Exhaustion | The definitive endoderm marker and the positive regulator of biliary development, FoxA2, mediates the therapeutic effect of biliary-committed progenitor cells during cholestatic liver injury. | 27639079 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Allogeneic stem cell transplantation is the only curative option for patients with acute myeloid leukemia (AML) experiencing relapse. | 27639553 |
| NES gene | Stem Cell Exhaustion | The collective expression of stem cell-related genes SOX2, OCT4, LGR5, TP63 (p63), as well as neural crest marker genes PSIP1 (p75(NTR)), PAX3, SOX9, AP2B1 (AP-2b), and NES, generated a phenotypic footprint of endothelial NCDPs. | 27639969 |
| Dystrophy | Stem Cell Exhaustion | Existence of Neural Crest-Derived Progenitor Cells in Normal and Fuchs Endothelial Dystrophy Corneal Endothelium. | 27639969 |
| Nephroblastoma | Stem Cell Exhaustion | Re-implantation of cryopreserved ovarian cortex resulting in restoration of ovarian function, natural conception and successful pregnancy after haematopoietic stem cell transplantation for Wilms tumour. | 27639996 |
| Nephroblastoma | Stem Cell Exhaustion | A 32-year-old woman had ovarian cortex cryopreserved 10 years previously before commencing high-dose chemotherapy and undergoing a haematopoietic stem cell transplant for recurrent adult Wilms tumour, which resulted in POI. | 27639996 |
| Multiple Myeloma | Stem Cell Exhaustion | Comparison of two dose levels of cyclophosphamide for successful stem cell mobilization in myeloma patients. | 27640002 |
| Multiple Myeloma | Stem Cell Exhaustion | Even in the era of proteasome inhibitors and immunomodulatory drugs, the autologous stem cell transplantation after high-dose melphalan continues to represent a standard approach for myeloma patients in first-line therapy. | 27640002 |
| Multiple Myeloma | Stem Cell Exhaustion | We retrospectively analyzed the impact of "intermediate-dose" (ID-CY, 2.5 g/m2) versus "high-dose" (HD-CY, 4 g/m2) cyclophosphamide in 101 (48 vs. 53) consecutively evaluable myeloma patients (median age 59 years, range 32-72 years) who underwent stem cell mobilization after induction chemotherapy. | 27640002 |
| Toxic effect, Multiple Myeloma | Stem Cell Exhaustion | ID-CY is safe and highly effective for stem cell mobilization in patients with newly diagnosed myeloma and associated with a reduced toxicity compared to HD-CY. | 27640002 |
| Neoplasms | Stem Cell Exhaustion | Mesenchymal stromal cells (MSCs) are multipotent progenitor cells and there is much interest in how MSCs contribute to the regulation of the tumor microenvironment. | 27641212 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Expression of migration-related genes in fast-migrating glioma cells is not only regulated in a progression-dependent manner, but these cells are also characterized by specific stem cell-like features. | 27641619 |
| Aplastic Anemia | Stem Cell Exhaustion | Effect of Recipient Age and Stem Cell Source on the Association between Donor Telomere Length and Survival after Allogeneic Unrelated Hematopoietic Cell Transplantation for Severe Aplastic Anemia. | 27641680 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | This study evaluated the safety and efficacy of thiotepa-based regimens before allogeneic stem cell transplantation in 310 adult patients with AML. | 27643865 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | In the CORAL study, 255 chemosensitive relapses with diffuse large B-cell lymphoma (DLBCL) were consolidated with autologous stem cell transplantation (ASCT), and 75 of them relapsed thereafter. | 27643872 |
| Degenerative polyarthritis, Cartilage | Stem Cell Exhaustion | While autologous chondrocyte or mesenchymal stem cell (MSC) implantation can be applied to repair cartilage defects in young patients, no appropriate long-lasting treatment alternative is available for elderly patients with osteoarthritis (OA). | 27644879 |
| Degenerative polyarthritis | Stem Cell Exhaustion | We therefore analyzed chondrocyte- and stem cell-related markers, cell growth rate, and multipotency in OA chondrocytes (OACs) and bone marrow-derived MSCs, along with normal articular chondrocytes (ACs) as a control. | 27644879 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Multipotent progenitor cells are reported to present in adult human articular cartilage, with a preponderance in OA cartilage. | 27644879 |
| Degenerative polyarthritis | Stem Cell Exhaustion | We conclude that chondrogenic capacity is not significantly affected by OA, and OACs could be a potential source of multipotent progenitor cells for cartilage tissue engineering. | 27644879 |
| Hepatitis C, Malignant Neoplasms, Communicable Diseases | Stem Cell Exhaustion | Exclusion criteria included previous exposure to HDAC inhibitors; previous allogeneic stem-cell transplantation; previous autologous stem-cell transplantation within 12 weeks of baseline; active systemic infection; malignancy within the last 5 years; known or suspected HIV, hepatitis B, or hepatitis C infection; a QTc Fridericia of more than 480 ms; and substantial cardiovascular, gastrointestinal, psychiatric, or other medical disorders. | 27646843 |
| mecarzole, Childhood Breast Carcinoma | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplantation (auto-HSCT) remains an experimental therapy for metastatic breast cancer (MBC) and there is no established protocol for cluster of differentiation 34+ (CD34+ ) hematopoietic progenitor cell (HPC) mobilization with historic studies using growth factors with or without chemotherapy. | 27649817 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Feasibility and kinetics of CD34+ hematopoietic progenitor cell mobilization in response to a single administration of docetaxel chemotherapy and pegfilgrastim in a contemporary cohort of patients with metastatic breast cancer. | 27649817 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Prognostic pre-transplant factors in myelodysplastic syndromes primarily treated by high dose allogeneic hematopoietic stem cell transplantation: a retrospective study of the MDS subcommittee of the CMWP of the EBMT. | 27650829 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Many pre-transplant factors are known to influence the outcome of allogeneic stem cell transplantation (SCT) treatment in myelodysplastic syndromes (MDS). | 27650829 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | Use of sodium hyaluronate and synthetic amino acid precursors of collagen for the symptomatic treatment of mucositis in patients undergoing haematopoietic stem cell transplants. | 27655517 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | Oral mucositis (OM) may occur in up to 100% of patients undergoing condition regimen to hematopoietic stem cell transplant (HSCT). | 27655517 |
| Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Patients treated with allogeneic hematopoietic stem cell transplantation (HSCT) may experience oral complications associated with chronic graft-versus-host disease (cGVHD). | 27655559 |
| Non-Malignant | Stem Cell Exhaustion | Hematopoietic stem cell transplantation is an established treatment for many malignant and non-malignant haematological disorders. | 27658169 |
| Hodgkin Disease | Stem Cell Exhaustion | In the current case report, we describe the first haploidentical stem cell transplantation, used for the first time in Romania, the case of a 33 year-old young woman diagnosed with Hodgkin's lymphoma that has underwent a haploSCT after she relapsed from several chemotherapy regimens, as well as after an autologous stem cell transplantation. | 27658169 |
| Infection | Stem Cell Exhaustion | Absent T-cell immunity resulting in life-threatening infections provides a clear rationale for hematopoetic stem cell transplantation (HSCT) in patients with severe combined immunodeficiency (SCID). | 27658761 |
| Primary Myelofibrosis | Stem Cell Exhaustion | Splenic pooling and loss of VCAM-1 causes an engraftment defect in patients with myelofibrosis after allogeneic hematopoietic stem cell transplantation. | 27662011 |
| Primary Myelofibrosis | Stem Cell Exhaustion | Improved engraftment in myelofibrosis might be achieved by approaches that reduce spleen size and cleavage of VCAM-1 in these patients prior to hematopoietic stem cell transplantation. | 27662011 |
| Primary Myelofibrosis | Stem Cell Exhaustion | In conclusion, our data suggest that reduced engraftment and graft failure in myelofibrosis patients is caused by an early pooling of CD34+ hematopoietic stem cells in the spleen and a bone marrow homing defect caused by the loss of VCAM-1. | 27662011 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | A prospective randomized trial comparing cyclosporine/methotrexate and tacrolimus/sirolimus as graft-versus-host disease prophylaxis after allogeneic hematopoietic stem cell transplantation. | 27662016 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Improvement of graft-versus-host disease prophylaxis remains an important goal in allogeneic hematopoietic stem cell transplantation. | 27662016 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Based on reports of possibly preferential properties of sirolimus, we compared the standard regimen of cyclosporine and methotrexate (n=106) with a combination of tacrolimus and sirolimus (n=103) as graft-versus-host disease prophylaxis after allogeneic hematopoietic stem cell transplantation in a prospective, open, randomized trial. | 27662016 |
| Graft-vs-Host Disease, tacrolimus | Stem Cell Exhaustion | We conclude that tacrolimus/sirolimus remains a valid and safe alternative to cyclosporine/methotrexate as graft-versus-host disease prophylaxis after allogeneic hematopoietic stem cell transplantation, with comparable transplant-related outcomes. | 27662016 |
| melanoma | Stem Cell Exhaustion | In malignant melanoma (MM), the proteins SOX10, ABCB5 and CD271 are strongly expressed, and are associated with tumour-initiating potential and stem cell-like properties. | 27663144 |
| Liver carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Identification of Keratin 19-Positive Cancer Stem Cells Associating Human Hepatocellular Carcinoma Using 18F-Fluorodeoxyglucose Positron Emission Tomography. | 27663597 |
| Liver carcinoma, Specialty Type - cancer, Hollings Cancer Center | Stem Cell Exhaustion | Purpose: The current lack of tools for easy assessment of cancer stem cells (CSC) prevents the development of therapeutic strategies for hepatocellular carcinoma (HCC). | 27663597 |
| TP53 gene | Stem Cell Exhaustion | Homozygous inactivation of Keap1 or Trp53 promoted airway basal stem cell (ABSC) self-renewal, suggesting that mutations in these genes lead to expansion of mutant stem cell clones. | 27663899 |
| Central Nervous System Infection | Stem Cell Exhaustion | Central nervous system infection following allogeneic hematopoietic stem cell transplantation. | 27664550 |
| Infection | Stem Cell Exhaustion | Here, we described the clinical characteristics and outcomes of central nervous system (CNS) infections occurring after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in a single institution over the previous 6 years. | 27664550 |
| Ischemic cardiomyopathy | Stem Cell Exhaustion | The IMPACT-CABG trial: A multicenter, randomized clinical trial of CD133+ stem cell therapy during coronary artery bypass grafting for ischemic cardiomyopathy. | 27665225 |
| Cardiomyopathies | Stem Cell Exhaustion | The IMPACT-CABG trial is the first North American multicenter phase II randomized study of intramyocardial delivery of autologous CD133+ stem cells in patients with chronic ischemic cardiomyopathy undergoing coronary artery bypass grafting. | 27665225 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Long-Lasting Protective Effect of Posaconazole Prophylaxis in Patients with Acute Myeloid Leukemia Receiving Allogeneic Hematopoietic Stem Cell Transplantation. | 27667012 |
| Leukemia, Myelocytic, Acute, Mycoses | Stem Cell Exhaustion | Patients with acute myeloid leukemia (AML) during induction chemotherapy and those who receive allogeneic hematopoietic stem cell transplantation (HSCT) are at higher risk of invasive fungal infections (IFI). | 27667012 |
| Aspects of mortality statistics | Stem Cell Exhaustion | Control of infectious mortality due to carbapenemase-producing Klebsiella pneumoniae in hematopoietic stem cell transplantation. | 27668762 |
| Cessation of life, Infection | Stem Cell Exhaustion | Carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) infections are an emerging cause of death after hematopoietic stem cell transplantation (HSCT). | 27668762 |
| leukemia | Stem Cell Exhaustion | Thiotepa-based conditioning for allogeneic stem cell transplantation in acute lymphoblastic leukemia-A survey from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. | 27673280 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | In this study, we analyzed a thiotepa-based conditioning regimen for allogeneic stem cell transplantation in adults with acute lymphoblastic leukemia, using the EBMT database. | 27673280 |
| Chronic graft-versus-host disease | Stem Cell Exhaustion | The proteome pattern cGvHD_MS14 allows early and accurate prediction of chronic GvHD after allogeneic stem cell transplantation. | 27677743 |
| Lymphoma | Stem Cell Exhaustion | Y90 -Ibritumomab tiuxetan (Y90 -IT) and high-dose melphalan as conditioning regimen before autologous stem cell transplantation for elderly patients with lymphoma in relapse or resistant to chemotherapy: a feasibility trial (SAKK 37/05). | 27677906 |
| Multiple Myeloma | Stem Cell Exhaustion | Prolonged survival with a longer duration of maintenance lenalidomide after autologous hematopoietic stem cell transplantation for multiple myeloma. | 27680710 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Although lenalidomide maintenance therapy has demonstrated improved outcomes after autologous hematopoietic stem cell transplantation (auto-HCT) for patients with multiple myeloma (MM), the impact of the duration of this therapy is not clearly known. | 27680710 |
| Squamous cell carcinoma of esophagus, Esophageal Neoplasms | Stem Cell Exhaustion | Gli1, a potential regulator of esophageal cancer stem cell, is identified as an independent adverse prognostic factor in esophageal squamous cell carcinoma. | 27680978 |
| Neoplasms, Cancer Stem Cells | Stem Cell Exhaustion | The hedgehog (Hh) pathway is involved in cancer stem cell (CSC) maintenance in various tumors. | 27680978 |
| Extrapulmonary Small Cell Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Gene set enrichment analysis revealed that the Gli1-high-expressing ESCC patients' group was strongly enriched for gene expression signature of Hh signaling pathway, epithelial-mesenchymal transition, and cancer stem cell. | 27680978 |
| Extrapulmonary Small Cell Carcinoma | Stem Cell Exhaustion | Targeting Gli1, a potential diagnostic marker of ESCC stem cells, will have a profound therapeutic and prognostic value. | 27680978 |
| Acquired disease | Stem Cell Exhaustion | Genetic inborn along with acquired diseases arise due to the lesions in genome of multipotent hematopoietic stem cells. | 27685529 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Absence of translocation t(9;22)(q34;q11) in blast transformed T-lymphocytes at diagnosis of CML evidences that this translocation may appear not only at the level of multipotent haemopoietic cell progenitors but also may have oligo lineage myeloid origin. | 27685529 |
| Malignant neoplasm of breast, Childhood Breast Carcinoma | Stem Cell Exhaustion | Low expression of galectin-3 is associated with poor survival in node-positive breast cancers and mesenchymal phenotype in breast cancer stem cells. | 27687248 |
| Neoplasms, Specialty Type - cancer, Transcription Initiation | Stem Cell Exhaustion | Galectin-3 (Gal3) plays diverse roles in cancer initiation, progression, and drug resistance depending on tumor type characteristics that are also associated with cancer stem cells (CSCs). | 27687248 |
| Lymphoma, Non-Hodgkin, Familial, Mature B-Lymphocyte, Natural Killer Cells, Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | A preventive effect of early human cytomegalovirus (HCMV) replication was evaluated in 136 non-Hodgkin lymphoma (NHL) patients with mature B-cell NHLs (n = 94), and mature T- and NK-cell NHLs (n = 42) after allogeneic stem cell transplantation (alloSCT). | 27687578 |
| Myelodysplastic-Myeloproliferative Diseases | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplant in adult patients with myelodysplastic syndrome/myeloproliferative neoplasm (MDS/MPN) overlap syndromes. | 27687869 |
| Myelodysplastic-Myeloproliferative Diseases, Myeloid neoplasm | Stem Cell Exhaustion | MDS/MPN (myelodysplastic syndrome/myeloproliferative neoplasm) overlap syndromes are myeloid malignancies for which allogeneic hematopoietic stem cell transplant (allo-HSCT) is potentially curative. | 27687869 |
| Hypoxia | Stem Cell Exhaustion | Furthermore, physiological O2 levels increased migration (P < 0.05) compared with room air and hypoxia, and treatment with mesenchymal stem cell-conditioned media rescued CSC migration under hypoxia to levels comparable to physiological O2 migration (2-fold, P < 0.05 relative to CSC media control). | 27694215 |
| Heart failure | Stem Cell Exhaustion | Cardiac stem cells (CSCs) are being evaluated for their efficacy in the treatment of heart failure. | 27694215 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Although the role of cancer stem cells (CSCs), a subset of tumor cells with the self-renewal and differentiation capabilities, in therapeutic resistance is beginning to be better understood, the significance of epigenetic regulatory mechanisms responsible for integrating the stemness with drug resistance remain poorly understood. | 27694900 |
| FAP protein, human | Stem Cell Exhaustion | To improve this situation, clinical application of pluripotent stem cell-derived MLs may be useful as an approach for FAP therapy. | 27695122 |
| leukemia | Stem Cell Exhaustion | In addition, patients receiving hematopoietic stem cell transplants for leukemia may do better if their donor has more activating KIR genes (i.e., KIR haplotype-B). | 27695964 |
| Neoplasms | Stem Cell Exhaustion | Recently aldehyde dehydrogenase 1A1 (ALDH1A1) was proposed as a stem cell marker for malignant PT but its expression has not been studied in benign and borderline tumours. | 27696244 |
| Histoplasmosis, Multiple Myeloma | Stem Cell Exhaustion | Gastrointestinal histoplasmosis in a patient after autologous stem cell transplant for multiple myeloma. | 27696648 |
| Post-transplant lymphoproliferative disorder, Lymphoproliferative Disorders | Stem Cell Exhaustion | Notably, hematopoietic stem cell transplantation (HSCT) recipients with a detectable blood EBV viral load (BEBVL) are considered at higher risk of post-transplant lymphoproliferative diseases (PTLD). | 27696681 |
| Primary Myelofibrosis, Thrombus, Hemorrhagic, Polycythemia Vera, Acute leukemia | Stem Cell Exhaustion | Polycythemia vera (PV) is an acquired clonal hematopoietic stem cell disorder characterized by an overproduction of red blood cells, white blood cells, and platelets; thrombotic and hemorrhagic complications; and an increased risk of transformation to myelofibrosis and acute leukemia. | 27697978 |
| Specialty Type - cancer | Stem Cell Exhaustion | The gradual accumulation of genetic mutations in human adult stem cells (ASCs) during life is associated with various age-related diseases, including cancer. | 27698416 |
| Lymphoma | Stem Cell Exhaustion | Outpatient administration of BEAM conditioning prior to autologous stem cell transplantation for lymphoma is safe, feasible, and cost-effective. | 27699999 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | High-dose BEAM chemotherapy (BCNU, etoposide, Ara-C, and melphalan) followed by autologous hematopoietic stem cell transplantation is frequently used as consolidative therapy for patients with recurrent or refractory Hodgkin or non-Hodgkin lymphoma. | 27699999 |
| Tissue damage | Stem Cell Exhaustion | Early hematopoietic stem cell transplantation is advisable before tissue damage is irreversible. | 27701760 |
| Epithelial, Inflammation, Photophobia, Usual Severity Pain | Stem Cell Exhaustion | Patients with limbal stem cell deficiency (LSCD) often experience pain and photophobia due to recurrent epithelial defects and chronic inflammation of the cornea. | 27702552 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | Novel population of small tumour-initiating stem cells in the ovaries of women with borderline ovarian cancer. | 27703207 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | Here, we show that a comparable population of small stem cells can be found in the ovarian tissue of women with borderline ovarian cancer, which, in contrast to small stem cells in "healthy" ovaries, formed spontaneous tumour-like structures and expressed some markers related to pluripotency and germinal lineage. | 27703207 |
| Malignant neoplasm of ovary, Specialty Type - cancer | Stem Cell Exhaustion | The gene expression profile of these small putative cancer stem cells differed from similar cells sorted from "healthy" ovaries by 132 upregulated and 97 downregulated genes, including some important forkhead box and homeobox genes related to transcription regulation, developmental processes, embryogenesis, and ovarian cancer. | 27703207 |
| Specialty Type - cancer | Stem Cell Exhaustion | These putative cancer stem cells are suggested to be a novel population of ovarian tumour-initiating cells in humans. | 27703207 |
| Specialty Type - cancer, Carcinoma, Transitional Cell | Stem Cell Exhaustion | Risk stratification by epithelial-mesenchymal transition and cancer stem cell-regulated genes, such as Snail and Bmi-1, might be useful prognostic markers for upper tract urothelial carcinoma. | 27704680 |
| Neoplasms | Stem Cell Exhaustion | Spontaneous tumour regression after high-dose therapy and autologous stem cell transplantation is associated with the aplastic anaemia-like syndrome and the presence of polyclonal autoantibodies against carbonic anhydrase I (CA I). | 27704726 |
| Bone necrosis | Stem Cell Exhaustion | The critical roles of IGFBP3 in regulating the osteogenic and adipogenic differentiation of bone marrow mesenchymal stem cells strongly indicate its potential effects on the pathogenesis of osteonecrosis of the femoral head (ONFH). | 27704894 |
| Adult Glioblastoma, Specialty Type - cancer | Stem Cell Exhaustion | Analysis of angiogenesis related factors in glioblastoma, peritumoral tissue and their derived cancer stem cells. | 27705944 |
| Specialty Type - cancer, Glioblastoma | Stem Cell Exhaustion | In this study, we evaluated by immunohistochemistry, and/or Western blotting and/or quantitative real time-PCR the expression of HIF1a, HIF2a, VEGF, VEGFR1 and VEGFR2 in surgical glioblastoma multiforme (GBM) and peritumoral tissue samples obtained from 50 patients as well as in cancer stem cells (CSCs) isolated from GBM (GCSCs) and peritumoral tissue (PCSCs) of 5 patients. | 27705944 |
| Columnar Metaplasia | Stem Cell Exhaustion | Most interestingly, it is a clinical example showcasing the origin of columnar metaplasia from stem cells located within the esophageal epithelium. | 27708180 |
| Neoplasms, Lymphoma | Stem Cell Exhaustion | Next-generation sequencing-based detection of circulating tumour DNA After allogeneic stem cell transplantation for lymphoma. | 27711974 |
| Lymphoma | Stem Cell Exhaustion | We evaluated whether the presence of ctDNA was associated with outcome after allogeneic haematopoietic stem cell transplantation (HSCT) in lymphoma patients. | 27711974 |
| Toxic effect | Stem Cell Exhaustion | A Comprehensive Assessment of Toxicities in Patients with Central Nervous System Lymphoma Undergoing Autologous Stem Cell Transplantation Using Thiotepa, Busulfan, and Cyclophosphamide Conditioning. | 27713090 |
| Primary central nervous system lymphoma, Toxic effect | Stem Cell Exhaustion | High-dose therapy and autologous stem cell transplantation (ASCT) with thiotepa, busulfan, and cyclophosphamide (TBC) conditioning has emerged as an effective postinduction treatment strategy for patients with primary central nervous system lymphoma (PCNSL) or secondary central nervous system lymphoma (SCNSL), but it is associated with considerable toxicity and transplantation-related mortality (TRM) in the modern era. | 27713090 |
| Specialty Type - cancer | Stem Cell Exhaustion | Variation in cancer risk among somatic tissues has been attributed to variations in the underlying rate of stem cell division. | 27716309 |
| Specialty Type - cancer | Stem Cell Exhaustion | For a given tissue type, variable cancer risk between individuals is thought to be influenced by extrinsic factors which modulate this rate of stem cell division. | 27716309 |
| Specialty Type - cancer | Stem Cell Exhaustion | To date, no molecular mitotic clock has been developed to approximate the number of stem cell divisions in a tissue of an individual and which is correlated with cancer risk. | 27716309 |
| Post-Traumatic Stress Disorder | Stem Cell Exhaustion | Cancer-and-treatment-specific distress and its impact on posttraumatic stress in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). | 27718504 |
| Post-Traumatic Stress Disorder | Stem Cell Exhaustion | In this prospective multicenter study, we investigated cancer-and-treatment-specific distress (CTXD) and its impact on symptoms of posttraumatic stress disorder (PTSD) in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). | 27718504 |
| Impaired cognition, "Alzheimers Disease | Stem Cell Exhaustion | Human Umbilical Cord Stem Cell Xenografts Improve Cognitive Decline and Reduce the Amyloid Burden in a Mouse Model of Alzheimer's Disease. | 27719629 |
| Neurodegenerative Disorders | Stem Cell Exhaustion | Over the past 20 years, stem cell technologies have become an increasingly attractive option to both study and potentially treat neurodegenerative diseases. | 27719629 |
| Up | Stem Cell Exhaustion | We aimed to explore the possible therapeutic potential of human umbilical cord mesenchymal stem cell xenografts in a transgenic (Tg) mouse model of AD. | 27719629 |
| Up | Stem Cell Exhaustion | APP/PS1 Tg AD model mice received human umbilical cord stem cells, directly injected into the carotid artery. | 27719629 |
| Up | Stem Cell Exhaustion | To test the efficacy of the umbilical cord stem cells in this AD model, behavioral tasks (sensorimotor and cognitive tests) and immunohistochemical quantitation of the pathology was performed. | 27719629 |
| Up, Cognitive | Stem Cell Exhaustion | Treatment of the APP/PS1 AD model mice, with human umbilical cord stem cells, produced a reduction of the amyloid beta burden in the cortex and the hippocampus which correlated with a reduction of the cognitive loss. | 27719629 |
| Up, Dental Plaque | Stem Cell Exhaustion | Human umbilical cord mesenchymal stem cells appear to reduce AD pathology in a transgenic mouse model as documented by a reduction of the amyloid plaque burden compared to controls. | 27719629 |
| Up | Stem Cell Exhaustion | Several investigators reported a beneficial effect of different types of stem or progenitor cells on the pathology and cognitive function in AD models. | 27719629 |
| Amyotrophic Lateral Sclerosis | Stem Cell Exhaustion | Intraspinal stem cell transplantation for amyotrophic lateral sclerosis: Ready for efficacy clinical trials? | 27720637 |
| Amyotrophic Lateral Sclerosis, Antilymphocyte Serum | Stem Cell Exhaustion | Intraspinal stem cell (SC) transplantation represents a new therapeutic approach for amyotrophic lateral sclerosis (ALS) clinical trials. | 27720637 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Allogeneic Stem Cell Transplantation for Patients Age >= 70 Years with Myelodysplastic Syndrome: A Retrospective Study of the MDS Subcommittee of the Chronic Malignancies Working Party of the EBMT. | 27720995 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | In this retrospective analysis we evaluated the outcome of 313 patients aged >= 70 years in the registry of the European Group for Blood and Marrow Transplantation with myelodysplastic syndrome (MDS; n = 221) and secondary acute myeloid leukemia (n = 92) who underwent allogeneic hematopoietic stem cell transplantation (HSCT) from related (n = 79) or unrelated (n = 234) donors. | 27720995 |
| Steroid-Refractory Pneumonitis | Stem Cell Exhaustion | Jak1/2 inhibitor ruxolitinib is a promising agent for treating steroid-refractory GvHD after allogeneic hematopoietic stem cell transplantation (SCT) to produce quick and durable responses. | 27721370 |
| Kidney Diseases | Stem Cell Exhaustion | Hematopoietic Stem Cell Transplantation Nephropathy Associated with Chronic Graft-versus-Host Disease without Extrarenal Involvement. | 27725545 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | A 30-year-old woman with myelodysplastic syndrome underwent allogeneic hematopoietic stem cell transplantation (HSCT) derived from her HLA-matched sister six years previously. | 27725545 |
| Cytomegalovirus Infections, Hematological Disease | Stem Cell Exhaustion | Cytomegalovirus infection in patients with haematological diseases and after autologous stem cell transplantation as consolidation: a single-centre study. | 27730340 |
| Myeloid, Myeloid Leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Accordingly, we addressed the applicability of human myeloid inhibitory C-lectin (hMICL) by flow cytometry as a specific leukemic myeloid stem cell marker for the diagnosis of AML in CD34+ and CD34- cases and evaluated the stability of hMICL during the course of the disease. | 27734526 |
| Muscular Dystrophy | Stem Cell Exhaustion | Small Fractions of Muscular Dystrophy Embryonic Stem Cells Yield Severe Cardiac and Skeletal Muscle Defects in Adult Mouse Chimeras. | 27734557 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | Hematopoietic stem cells can be separated from leukemic cells in a subgroup of adult acute lymphoblastic leukemia patients. | 27734718 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | In B-cell acute lymphoblastic leukemia (B-ALL) separation of normal hematopoietic stem cells (HSC) has so far been limited to a subgroup of patients. | 27734718 |
| Multiple Myeloma | Stem Cell Exhaustion | Upfront use of plerixafor and granulocyte-colony stimulating factor (GCSF) for stem cell mobilization in patients with multiple myeloma: efficacy and analysis of risk factors associated with poor stem cell collection efficiency. | 27735212 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Plerixafor (P), an agent that selectively and reversibly binds to the chemokine receptor CXCR4, has been approved in combination with G-CSF (P + G-CSF) for stem cell (SC) mobilization in patients with multiple myeloma (MM). | 27735212 |
| Multiple Myeloma | Stem Cell Exhaustion | Autologous stem cell transplantation in elderly patients with multiple myeloma: evaluation of its safety and efficacy. | 27736269 |
| Malignant tumor of colon | Stem Cell Exhaustion | CD24 is a membrane protein that acts as the ligand for P-selectin and has been defined as a stem cell marker of colonic cancer. | 27738793 |
| Specialty Type - cancer | Stem Cell Exhaustion | The role of cancer stem cells in the initiation and progression of cancer has become a well-studied area of emerging research, and stem cells with different surface markers have been identified in various types of cancer. | 27738793 |
| Chemotherapy-induced nausea and vomiting | Stem Cell Exhaustion | A randomized trial of olanzapine versus palonosetron versus infused ondansetron for the treatment of breakthrough chemotherapy-induced nausea and vomiting in patients undergoing hematopoietic stem cell transplantation. | 27738796 |
| Chemotherapy-induced nausea and vomiting, Chemotherapy-induced Nausea and Vomiting Questionnaire | Stem Cell Exhaustion | The primary aim of this study was to compare the effectiveness of olanzapine, palonosetron and ondansetron infusion (standard of care) for the treatment of breakthrough chemotherapy-induced nausea and vomiting (CINV) in patients undergoing hematopoietic stem cell transplantation (HSCT). | 27738796 |
| Endocrine Disruptors, Fibroid Tumor | Stem Cell Exhaustion | Developmental Exposure to Endocrine Disruptors Expands Murine Myometrial Stem Cell Compartment as a Prerequisite to Leiomyoma Tumorigenesis. | 27739139 |
| LMNA wt Allele | Stem Cell Exhaustion | A High Throughput Phenotypic Screening reveals compounds that counteract premature osteogenic differentiation of HGPS iPS-derived mesenchymal stem cells. | 27739443 |
| LMNA wt Allele | Stem Cell Exhaustion | Thanks to the pluripotency and self-renewal properties of induced pluripotent stem cells (iPSC), HGPS iPSC-based modeling opens up the possibility of access to different relevant cell types for pharmacological approaches. | 27739443 |
| LMNA wt Allele | Stem Cell Exhaustion | In this study, 2800 small molecules were explored using high-throughput screening, looking for compounds that could potentially reduce the alkaline phosphatase activity of HGPS mesenchymal stem cells (MSCs) committed into osteogenic differentiation. | 27739443 |
| Prostate carcinoma | Stem Cell Exhaustion | In addition, we investigated a non-dioxin-like PCB153-induced cell invasion and related markers in normal prostate stem cells (WPE-stem) and in three different prostate cancer cell lines (PC3, DU145 and 22RV1) at exposure levels relevant to humans. | 27742691 |
| Prostate carcinoma | Stem Cell Exhaustion | Cell invasion and related markers, including MMP9, MMP2, Slug and Snail, were significantly increased in human prostate cancer cells as well as in prostate stem cells after exposure to PCB153. | 27742691 |
| Gastrointestinal infection | Stem Cell Exhaustion | Gastrointestinal infections by cytomegalovirus (CMV) and adenovirus may complicate hematopoietic stem cell transplantation (HSCT). | 27744342 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We have retrospectively compared survivals between acute myeloid leukemia (AML)/myelodysplastic syndrome (MDS) patients who received either a clofarabine/busulfan (CloB2A2) or a fludarabine/busulfan (FB2A2) RIC regimen for allogeneic stem cell transplantation. | 27748046 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells (CSCs) have self-renewal and pluripotency capabilities and contribute to cancer progression and chemoresistance. | 27748881 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | Promising treatment results with blood brain barrier disruption (BBBD) based immunochemotherapy combined with autologous stem cell transplantation (ASCT) in patients with primary central nervous system lymphoma (PCNSL). | 27752883 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Severe graft-versus-host disease is a major barrier for non-T-cell-depleted haploidentical stem cell transplantation. | 27758821 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | AML-LTC are established by isolating mononuclear cells from peripheral blood samples of AML patients followed by selection of CD34+ progenitor cells. | 27761818 |
| Toxic effect | Stem Cell Exhaustion | Overall, combination fludarabine-melphalan with low-dose TBI after haplocord stem cell transplant assures good engraftment and leads to acceptable toxicity and disease control in the setting of high risk, heavily pretreated patients. | 27764032 |
| Tachycardia, Ventricular | Stem Cell Exhaustion | Patient-Specific Human Induced Pluripotent Stem Cell Model Assessed with Electrical Pacing Validates S107 as a Potential Therapeutic Agent for Catecholaminergic Polymorphic Ventricular Tachycardia. | 27764147 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Clinical sample sets of throat swab, EDTA-blood and blood sera from 50 patients with severe haematological malignancies, including haematopoietic stem cell transfer (HSCT), and samples from 30 healthy individuals were then analysed. | 27765533 |
| Hypovolemic Shock | Stem Cell Exhaustion | Pediatric apheresis for peripheral blood stem cell transplantation should be carried out with due concern for low corporeal blood volume and vulnerability to hypocalcemia-related complications, hypovolemic shock, and hypervolemic cardiac overload. | 27765663 |
| Malignant neoplasm of lung, Pneumonia | Stem Cell Exhaustion | The aims of this study were to describe the computed tomographic features of organizing pneumonia (OP) in an oncologic patient population and to also identify features associated with lung cancer and patients undergoing hematopoietic stem cell transplant (HSCT). | 27768620 |
| pM category, Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | Combination of Cancer Stem Cell Markers CD44 and CD24 Is Superior to ALDH1 as a Prognostic Indicator in Breast Cancer Patients with Distant Metastases. | 27768764 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | The combination of CD44 and CD24, or aldehyde dehydrogenase 1 (ALDH1) alone, is a widely used cancer stem cell marker in breast cancer. | 27768764 |
| Specialty Type - cancer | Stem Cell Exhaustion | Immunohistochemical evaluation using cancer stem cell markers is clearly less common clinically than in basic experiments and how the expressions of these markers relate to patient outcomes remains controversial. | 27768764 |
| Retinal Pigments | Stem Cell Exhaustion | Several cell types in culture generate TA4 from ambient thyroxine, including fibrocytes, HELA cells, human Muller stem cells, and retinal pigmented epithelial cells. | 27768856 |
| Chronic graft-versus-host disease | Stem Cell Exhaustion | We applied TCR-a-NGS to samples from two patients with chronic GVHD who received comparable doses of stem cell donor derived expanded Treg . | 27774628 |
| Multiple Myeloma | Stem Cell Exhaustion | Peripheral blood stem cell mobilization in multiple myeloma comparison of two consecutive regimens in a limited resources country. | 27775695 |
| Toxic effect | Stem Cell Exhaustion | This study compared retrospectively the effectiveness, toxicity and hematopoietic recovery after autologous peripheral blood stem cell transplantation (ASCT) of two consecutive peripheral blood stem cell mobilization regimens in newly diagnosed MM patients. | 27775695 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients with Myelodysplastic Syndrome Harboring Trisomy 8. | 27777139 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | However, the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) in adult patients with MDS harboring +8 remains unclear. | 27777139 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Outcome of FLT3-ITD-positive acute myeloid leukemia: impact of allogeneic stem cell transplantation and tyrosine kinase inhibitor treatment. | 27778197 |
| FLT3 Internal Tandem Duplication | Stem Cell Exhaustion | In particular, FLT3 internal tandem duplications (FLT3-ITD) are characterized by an unfavorable prognosis and allogeneic stem cell transplantation (allogeneic SCT) in first complete remission is recommended. | 27778197 |
| Hypertension, CTCAE | Stem Cell Exhaustion | This randomized study evaluates the effects of lercanidipine - as well as its antihypertensive efficacy - on the number of circulating endothelial progenitor cells (EPCs) in elderly patients with hypertension. | 27779456 |
| Neoplasms, Specialty Type - cancer, Childhood Breast Carcinoma, Secondary Neoplasm | Stem Cell Exhaustion | Cancer stem cells (CSCs) have been suggested to serve an important role in tumor recurrence and metastasis in breast cancer. | 27779682 |
| Colorectal Carcinoma | Stem Cell Exhaustion | Effect of colorectal cancer on the number of normal stem cells circulating in peripheral blood. | 27779706 |
| Inflammation, Traumatic AND/OR non-traumatic injury | Stem Cell Exhaustion | Bone marrow (BM) residing stem cells are mobilized from their BM niches into peripheral blood (PB) in several pathological situations including tissue organ injury and systemic inflammation. | 27779706 |
| Pancreatic carcinoma | Stem Cell Exhaustion | We recently reported that the number of BM-derived stem cells (SCs) increases in patients with pancreatic and stomach cancer. | 27779706 |
| Negative Regulation of Cell Cycle, Stem cells | Stem Cell Exhaustion | Overexpression of miRNA148a in ATC-CSCs induced cell cycle arrest and loss of stem cell characteristics. | 27779717 |
| Neoplasms | Stem Cell Exhaustion | Overexpression of miRNA-148a and knockdown of INO80 acted synergistically to decrease the expression of stem cell marker genes as well as to attenuate stem cell-specific properties including the ability to form tumors. | 27779717 |
| Malignant neoplasm of thyroid | Stem Cell Exhaustion | miR-148a inhibits self-renewal of thyroid cancer stem cells via repressing INO80 expression. | 27779717 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells (CSCs) are proposed to be responsible for high recurrence rate in ATC. | 27779717 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Fibulin 3 regulates differentiation of adult progenitor cells, and its aging-related decline is an early event in the pathogenesis of OA. | 27780308 |
| Arteriovenous fistula, Thrombosis | Stem Cell Exhaustion | Circulating Progenitor Cells Affect Thrombosis of Dialysis Arteriovenous Fistulas. | 27784005 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | Endothelial progenitor cells (EPCs) are mobilized into circulation under various pathophysiological conditions, and are thought to play an important role in tissue repair in chronic obstructive lung disease (COPD). | 27784320 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | Therefore, Sirt1 and EPC-associated mRNAs were measured in blood samples from patients with COPD and from cultured CD34+ progenitor cells to examine whether these genes are associated with COPD development. | 27784320 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Outcome differences between children and adolescents and young adults with non-Hodgkin lymphoma following stem cell transplantation. | 27787746 |
| Leukemia, Myelocytic, Acute, Acute lymphocytic leukemia | Stem Cell Exhaustion | Several studies of patients with acute lymphoblastic leukemia and acute myeloid leukemia who received stem cell transplantation (SCT) have reported that adolescents and young adults (AYAs) experience higher transplant-related mortality than that in younger children. | 27787746 |
| Lymphoma, Non-Hodgkin, Familial | Stem Cell Exhaustion | We analyzed 918 patients aged 30 years and younger who received their first stem cell transplantation for NHL. | 27787746 |
| Malignant tumor of colon | Stem Cell Exhaustion | Identification of High-Risk Aberrant Crypt Foci and Mucin-Depleted Foci in the Human Colon With Study of Colon Cancer Stem Cell Markers. | 27789195 |
| Specialty Type - cancer | Stem Cell Exhaustion | Detailed topographic analyses, with immunohistochemical staining for b-catenin and cancer stem cell (CSC) markers (CD44, CD24, and CD166) were performed. | 27789195 |
| Mucopolysaccharidosis II | Stem Cell Exhaustion | Generation of Mucopolysaccharidosis type II (MPS II) human induced pluripotent stem cell (iPSC) line from a 7-year-old male with pathogenic IDS mutation. | 27789394 |
| Mucopolysaccharidosis II | Stem Cell Exhaustion | Generation of Mucopolysaccharidosis type II (MPS II) human induced pluripotent stem cell (iPSC) line from a 3-year-old male with pathogenic IDS mutation. | 27789398 |
| Mucopolysaccharidosis II | Stem Cell Exhaustion | Generation of Mucopolysaccharidosis type II (MPS II) human induced pluripotent stem cell (iPSC) line from a 1-year-old male with pathogenic IDS mutation. | 27789399 |
| Spastic Paraplegia, Hereditary, HSP90B2P wt Allele | Stem Cell Exhaustion | Establishment of SPAST mutant induced pluripotent stem cells (iPSCs) from a hereditary spastic paraplegia (HSP) patient. | 27789400 |
| Mucopolysaccharidosis II | Stem Cell Exhaustion | Generation of human induced pluripotent stem cell (iPSC) line from an unaffected female carrier of Mucopolysaccharidosis type II (MPS II) disorder. | 27789401 |
| Autistic Disorder, KLEEFSTRA SYNDROME 1, Kaposi Sarcoma | Stem Cell Exhaustion | Establishment of EHMT1 mutant induced pluripotent stem cell (iPSC) line from a 11-year-old Kleefstra syndrome (KS) patient with autism and normal intellectual performance. | 27789404 |
| Up, "Alzheimers Disease | Stem Cell Exhaustion | Human lymphoblast cells from a female patient diagnosed with Alzheimer's disease (AD) possessing the missense mutation TREM2 p.R47H were used to generate integration-free induced pluripotent stem cells (iPSCs) employing episomal plasmids expressing OCT4, SOX2, NANOG, LIN28, c-MYC and L-MYC. | 27789408 |
| Pick Disease of the Brain | Stem Cell Exhaustion | Induced pluripotent stem cells (iPSCs) derived from a symptomatic carrier of a S305I mutation in the microtubule-associated protein tau (MAPT)-gene causing frontotemporal dementia. | 27789411 |
| Ischemic cardiomyopathy | Stem Cell Exhaustion | An exploratory randomized control study of combination cytokine and adult autologous bone marrow progenitor cell administration in patients with ischaemic cardiomyopathy: the REGENERATE-IHD clinical trial. | 27790824 |
| Infection, Specialty Type - cancer | Stem Cell Exhaustion | Participants completed a 402-item questionnaire regarding the use of CAM, medical complications, specialist referrals, medications and therapies, infections, vaccinations, cancer screening, lifestyle, and occupational issues and relationship status following stem cell transplantation. | 27790858 |
| Sepsis | Stem Cell Exhaustion | Diagnostic value of sepsis biomarkers in hematopoietic stem cell transplant recipients in a condition of high prevalence of gram-negative pathogens. | 27793578 |
| Febrile Neutropenia, Communicable Diseases | Stem Cell Exhaustion | A decision about the need for antimicrobial therapy in a patient with febrile neutropenia after hematopoietic stem cell transplantation (HSCT) is often complicated because of the low frequency of culture isolation and reduced clinical manifestation of infection. | 27793578 |
| ACVR1 wt Allele | Stem Cell Exhaustion | Contrary to a previous study, here we show that FOP fibroblasts showed an increased efficiency of induced pluripotent stem cell (iPSC) generation. | 27794120 |
| Infection | Stem Cell Exhaustion | We analyzed the incidence, clinical characteristics, prognostic factors, and outcome of central nervous system (CNS) infections in consecutive patients with receiving umbilical cord blood transplantation (UCBT) (n = 343) or HLA-matched sibling donor stem cell transplantation (MST) (n = 366). | 27794456 |
| Infection | Stem Cell Exhaustion | In conclusion, our study showed that CNS infections are a significant clinical problem after stem cell transplantation associated with poor survival. | 27794456 |
| Parkinson Disease | Stem Cell Exhaustion | The Transcriptional Changes of trim Genes Associated with Parkinson's Disease on a Model of Human Induced Pluripotent Stem Cells. | 27796756 |
| Neurodegenerative Disorders | Stem Cell Exhaustion | Over the last few years, in vitro models, based on patient-derived induced pluripotent stem cells (iPSCs), have received considerable attention for modeling different neurodegenerative disorders. | 27796756 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Imatinib Mesylate Versus Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Chronic Myelogenous Leukemia. | 27797264 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | To compare the relative merits of imatinib and allogeneic hematopoietic stem cell transplantation (allo-HSCT) for chronic myelogenous leukemia (CML). | 27797264 |
| CARCINOMA OF VULVA, Specialty Type - cancer | Stem Cell Exhaustion | Immunological and Clinical Impact of Cancer Stem Cells in Vulvar Cancer: Role of CD133/CD24/ABCG2-Expressing Cells. | 27798870 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells (CSCs) are tumour-initiating cells with self-renewal properties and chemo/radio-resistance. | 27798870 |
| Leukemia, Myelocytic, Acute, NPM1 wt Allele | Stem Cell Exhaustion | Pre-transplant Quantitative Determination of NPM1 Mutation Significantly Predicts Outcome of AIlogeneic Hematopoietic Stem Cell Transplantation in Patients with Normal Karyotype AML in Complete Remission. | 27798920 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Minimal residual disease (MRD) in patients with acute myeloid leukemia (AML) before allogeneic hematopoietic stem cell transplantation (alloHSCT) can influence the results of therapy. | 27798920 |
| Colorectal Carcinoma | Stem Cell Exhaustion | Evaluation of circulating cellular DCLK1 protein, as the most promising colorectal cancer stem cell marker, using immunoassay based methods. | 27802206 |
| Colorectal Carcinoma | Stem Cell Exhaustion | DCLK1, as the most potential colorectal cancer stem cell (CSC) marker has been the core of many recent investigations. | 27802206 |
| Ataxia, Spinocerebellar | Stem Cell Exhaustion | Fusion of Human Fetal Mesenchymal Stem Cells with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice. | 27802273 |
| ovarian neoplasm | Stem Cell Exhaustion | Here, we demonstrate that EGFL6, a stem cell regulatory factor expressed in ovarian tumor cells and vasculature, regulates ALDH+ ovarian CSC. | 27803106 |
| Encephalitis, Hematologic Neoplasms, Pregnancy Complications, Infectious | Stem Cell Exhaustion | Toxoplasmic encephalitis is a rare infectious complication in patients with hematological malignancy except for allogeneic hematopoietic stem cell transplantation (HSCT). | 27803415 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Leptin Level in Patients with Type 2 Diabetes Mellitus after Fetal Pancreatic Stem Cell Transplant. | 27805510 |
| Pancreas Transplantation, Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | We aimed to determine leptin level in patients with type 2 diabetes mellitus after fetal pancreatic stem cell transplant. | 27805510 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | In patients with type 2 diabetes mellitus, fetal pancreatic stem cell transplant led to a significant increase in leptin levels, from 11.01 ng/mL to 16.29 ng/mL, after 3 months (P < .05). | 27805510 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Leptin level increase significantly within 3 months after fetal pancreatic stem cell transplant in patients with type 2 diabetes mellitus. | 27805510 |
| Colorectal Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | A comparison of cancer stem cell markers and nonclassical major histocompatibility complex antigens in colorectal tumor and noncancerous tissues. | 27806848 |
| Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | Cancer stem cells (CSCs) are associated with poor prognosis, metastasis, and recurrence, as well as chemotherapy and radiotherapy resistance. | 27806848 |
| Barrett Esophagus, Adenocarcinoma Of Esophagus | Stem Cell Exhaustion | Goblet Cell Ratio in Combination with Differentiation and Stem Cell Markers in Barrett Esophagus Allow Distinction of Patients with and without Esophageal Adenocarcinoma. | 27807078 |
| Neoplasms | Stem Cell Exhaustion | Increasing stem cell marker LGR5 and niche cell marker DCLK1 and decreasing differentiation marker (secretory mucus cells, TFF2+ cells) correlated with elevated tumor score in the mouse. | 27807078 |
| Graft-vs-Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | CD4+ regulatory T cells (CD4Tregs) play a critical role in the maintenance of immune tolerance and prevention of chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation. | 27812545 |
| Febrile Neutropenia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We retrospectively evaluated the use of computed tomography abdomen and pelvis (CTAP) in febrile neutropenic autologous stem cell transplant (ASCT) and acute myeloid leukaemia (AML) patients. | 27813352 |
| Colorectal Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | The CEA-/lo colorectal cancer cell population harbors cancer stem cells and metastatic cells. | 27813496 |
| Colorectal Carcinoma | Stem Cell Exhaustion | In this study, 454 primary colorectal carcinomas were analyzed histologically and immunohistochemically for CD274, mismatch repair (MMR) proteins, intestinal differentiation marker (CDX2), and stem cell markers (ALCAM, ALDH1A1, and SALL4). | 27813511 |
| Exocrine pancreas | Stem Cell Exhaustion | Pancreatic duct glands (PDGs) have been proposed as a source of regeneration in response to exocrine pancreas injury, and thus may serve as an organ stem cell niche. | 27813705 |
| Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8 | Stem Cell Exhaustion | To investigate the PDG compartment of the pancreas in humans with T1D for evidence of an active regenerative signature (presence of progenitor cells and increased proliferation) and, in particular, as a potential source of b-cells. | 27813705 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | In this study we evaluated the ability of circulating stem cell levels to predict future cardiovascular outcomes and improve risk discrimination in patients with type 2 diabetes. | 27815289 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Long-term Prediction of Cardiovascular Outcomes by Circulating CD34+ and CD34+CD133+ Stem Cells in Patients With Type 2 Diabetes. | 27815289 |
| Cessation of life, Diabetes | Stem Cell Exhaustion | Circulating stem cells predict future cardiovascular events and death, but data for the population with diabetes are scant. | 27815289 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | In patients with type 2 diabetes, a reduced baseline level of circulating CD34+ stem cells predicts adverse cardiovascular outcomes up to 6 years later and improves risk stratification. | 27815289 |
| leukemia | Stem Cell Exhaustion | Sequential Intensified Conditioning Regimen Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients with Intermediate- or High-Risk Acute Myeloid Leukemia in Complete Remission: A Study from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation. | 27816650 |
| Failure, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Post-transplant relapse is the leading cause of treatment failure in acute myeloid leukemia (AML) patients after reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 27816650 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | Clofarabine Plus Busulfan is an Effective Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Acute Lymphoblastic Leukemia: Long-Term Study Results. | 27816651 |
| Acute lymphocytic leukemia, BCR gene | Stem Cell Exhaustion | busulfan (Bu) combined with clofarabine (Clo) in patients with acute lymphoblastic leukemia (ALL) undergoing allogeneic hematopoietic stem cell transplantation (HSCT). | 27816651 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Consequently, patients can be offered hematopoietic stem cell transplantation (HSCT) from alternative donors, including mismatched unrelated donors (MMURD), known to cause a higher incidence of acute GVHD (aGVHD) and chronic GVHD. | 27819684 |
| Extrahepatic Cholangiocarcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Aberrant activation of Notch signaling in extrahepatic cholangiocarcinoma: clinicopathological features and therapeutic potential for cancer stem cell-like properties. | 27821106 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Notch signaling has been reported to be related to cancer stem cell (CSC) like properties in some malignancies. | 27821106 |
| Leukemia, Myelocytic, Acute, Acute leukemia | Stem Cell Exhaustion | Long-term survival and late events after allogeneic stem cell transplantation from HLA-matched siblings for acute myeloid leukemia with myeloablative compared to reduced-intensity conditioning: a report on behalf of the acute leukemia working party of European group for blood and marrow transplantation. | 27821187 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Myeloablative (MAC) and reduced-intensity conditioning (RIC) are established approaches for allogeneic stem cell transplantation (SCT) in acute myeloid leukemia (AML). | 27821187 |
| Infection | Stem Cell Exhaustion | Risk Factors and Outcomes of Infections by Multidrug-Resistant Gram-Negative Bacteria in Patients Undergoing Hematopoietic Stem Cell Transplantation. | 27826061 |
| Infection, Multi-Drug Resistance | Stem Cell Exhaustion | The objective of this study was to determine risk factors and outcomes of infections by multidrug-resistant gram-negative (MDR GN) bacteria in 241 recipients of hematopoietic stem cell transplantation (HSCT). | 27826061 |
| Aggressive natural killer-cell leukemia | Stem Cell Exhaustion | Achievement of disease control with donor-derived EB virus-specific cytotoxic T cells after allogeneic peripheral blood stem cell transplantation for aggressive NK-cell leukemia. | 27830541 |
| Brain Diseases, Metabolic, Inborn, Degenerative disorder, Single organ dysfunction | Stem Cell Exhaustion | Different types of stem cells with hepatic differentiation potential are eligible for generating large numbers of functional hepatocytes for liver cell therapy to treat degenerative disorders, inborn hepatic metabolic diseases, and organ failure. | 27830543 |
| Hematologic Neoplasms, Malignant Neoplasms, Diabetes Mellitus | Stem Cell Exhaustion | Underlying conditions were haematological malignancies (46 %), other malignancies (6.3 %), haematopoietic stem cell transplantation (15.9 %), solid organ transplantation, trauma/surgery and diabetes mellitus (4.8 % each) and a variety of other diseases (7.9 %); in 9.5%, no underlying medical condition was found. | 27832748 |
| Cessation of life | Stem Cell Exhaustion | In regression analysis, disseminated disease and prior haematopoietic stem cell transplantation were associated with increased odds of death, whereas the combination of systemic antifungal therapy with surgery was associated with improved survival. | 27832748 |
| Specialty Type - cancer, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Aldehyde dehydrogenase 1 (ALDH1), a marker of cancer stem cells, is also associated with metastasis and poor prognosis in many tumors. | 27832750 |
| Liver carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | miR-589-5p inhibits MAP3K8 and suppresses CD90+ cancer stem cells in hepatocellular carcinoma. | 27835990 |
| Liver carcinoma, Specialty Type - cancer, Hollings Cancer Center | Stem Cell Exhaustion | Cancer stem cells (CSCs) are important in the tumorigenesis and progression of hepatocellular carcinoma (HCC). | 27835990 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | Circulating osteogenic endothelial progenitor cell counts: new biomarker for the severity of coronary artery disease. | 27836295 |
| Atherosclerosis | Stem Cell Exhaustion | There is increasing evidence implying that the early and functionally highly active circulating endothelial progenitor cell (CEPC) phenotype (CD34-/CD133+/KDR+) with osteogenic potential (OCN+) might link between vascular atherosclerotic calcification and mechanisms of bone metabolism. | 27836295 |
| VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | Stem Cell Exhaustion | Subsequent vitiligo after hematopoietic stem cell transplantation: A nationwide population-based cohort study from Korea. | 27836331 |
| VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | Stem Cell Exhaustion | Subsequent vitiligo after hematopoietic stem cell transplantation (HSCT) has been described sporadically in case series. | 27836331 |
| VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | Stem Cell Exhaustion | Allogeneic HSCT (OR 5.593, 95% CI 1.628-19.213) and bone marrow-sourced stem cells (as compared with peripheral blood-sourced stem cells; OR 2.492, 95% CI 1.114-5.576) were independently associated with the development of vitiligo after HSCT. | 27836331 |
| Hematopoietic stem cells, PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The myelodysplastic syndromes (MDS) are a heterogeneous group of clonal haematopoietic stem cell disorders characterised by inefficient haematopoiesis and risk of progression to acute myeloid leukaemia. | 27836923 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | The distribution of CD44+/CD24- cancer stem cells in breast cancer and its relationship with prognostic factors. | 27837613 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | The purpose of this study was to investigate the correlation between the percentages of CD44+/CD24- cancer stem cells (CSCs) and the clinicopathological and prognostic factors in breast cancer patients. | 27837613 |
| Specialty Type - cancer | Stem Cell Exhaustion | Pupose: Nestin and CD133 are regarded as putative markers of cancer stem cells (CSCs) and related to poor prognosis in various cancer sites. | 27837619 |
| Peripheral Blood Stem Cells | Stem Cell Exhaustion | Although autologous stem cell transplantation can achieve excellent responses in patients with POEMS syndrome, the optimal regimen for peripheral blood stem cell (PBSC) collection is still controversial. | 27840209 |
| Cessation of life, HCK gene | Stem Cell Exhaustion | Herein, we describe a new specific pharmacological hematopoietic cell kinase (HCK) inhibitor (iHCK-37) that was able to reduce PI3K/AKT and MAPK/ERK pathways activation after erythropoietin induction in cells with high HCK expression: iHCK-37 treatment increased leukemic cells death and, very importantly, did not affect normal hematopoietic stem cells. | 27840303 |
| MYELODYSPLASTIC SYNDROME, PAFAH1B1 wt Allele, HCK gene, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Notably, HCK levels were highly increased in stem cells from patients with some diseases, as Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML), that are associated with ineffective erythropoiesis These discoveries support the exploration of the new pharmacological iHCK-37 in future preclinical and clinical studies. | 27840303 |
| Reperfusion Injury | Stem Cell Exhaustion | The cell type that survives and maintains stem cell characteristics in the adverse microenvironment following ischemia-reperfusion injury is presumed to be ideal for transplantation. | 27844250 |
| Microbiological, Communicable Diseases | Stem Cell Exhaustion | Rates of Microbiologically Diagnosed Infection and Pathogen Detection in Hematopoietic Stem Cell Transplant Patients. | 27849508 |
| Infection | Stem Cell Exhaustion | Infections remain a significant cause of mortality in hematopoietic stem cell transplant patients. | 27849508 |
| Communicable Diseases | Stem Cell Exhaustion | We performed a retrospective analysis of infection rates and microbiologic testing yield, or percent of tests ordered to diagnose an infection, in the first 100 days of 30 allogeneic and 56 autologous stem cell transplants performed at San Antonio Military Medical Center from July 2011 to April 2014. | 27849508 |
| Communicable Diseases | Stem Cell Exhaustion | Improved diagnostic tests and methods are needed to increase yield of detection of infection in hematopoietic stem cell transplant patients. | 27849508 |
| Fibrosis Assessment, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Early Improvement in Marrow Fibrosis Following Haploidentical Stem Cell Transplantation for a Patient with Myelodysplastic Syndrome with Bone Marrow Fibrosis. | 27853082 |
| Myeloproliferative disease | Stem Cell Exhaustion | Myeloproliferative neoplasms are clonal hematopoietic stem cell disorders characterized by aberrant proliferation and an increased tendency toward leukemic transformation. | 27855276 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Comprehensive recommendations for maintenance therapy after autologous stem cell transplantation (ASCT) for patients with multiple myeloma (MM) have yet to be defined. | 27856369 |
| Colonization, Communicable Diseases | Stem Cell Exhaustion | Chlorhexidine bathing for the prevention of colonization and infection with multidrug-resistant microorganisms in a hematopoietic stem cell transplantation unit over a 9-year period: Impact on chlorhexidine susceptibility. | 27861350 |
| Infection, Thais (Population Group) | Stem Cell Exhaustion | Health care associated infections (HAIs) are currently among the major challenges to the care of hematopoietic stem cell transplantation (HSCT) patients. | 27861350 |
| Disseminated, Candidiasis | Stem Cell Exhaustion | Thalidomide for steroid-dependent chronic disseminated candidiasis after stem cell transplantation: A case report. | 27862711 |
| Hepatic Vein Thrombosis | Stem Cell Exhaustion | Number and function of circulating endothelial progenitor cells in patients with primary Budd-Chiari syndrome. | 27863925 |
| Endothelium | Stem Cell Exhaustion | Circulating endothelial progenitor cells (EPCs) provide an endogenous mechanism to repair endothelial injury. | 27863925 |
| leukemia | Stem Cell Exhaustion | The long-term outcome of reduced-intensity allogeneic stem cell transplantation from a matched related or unrelated donor, or haploidentical family donor in patients with leukemia: a retrospective analysis of data from the China RIC Cooperative Group. | 27864604 |
| Precapillary pulmonary hypertension | Stem Cell Exhaustion | Effect of targeted therapy on circulating progenitor cells in precapillary pulmonary hypertension. | 27865192 |
| Endothelial dysfunction, Pulmonary Hypertension | Stem Cell Exhaustion | Endothelial dysfunction is key in the development of pulmonary hypertension (PH) and is associated with reduced number of circulating progenitor cells. | 27865192 |
| Pulmonary Hypertension | Stem Cell Exhaustion | PAH-targeted therapy increases levels of progenitors in PAH but not in CTEPH, suggesting different involvement of progenitor cells in the pathobiology of these pulmonary hypertensive disorders. | 27865192 |
| White matter lesions | Stem Cell Exhaustion | To understand how the microenvironment within white matter lesions plays a role in repair we have focused on neural progenitor cells (NPCs) since these are found in lesions in PPMS and have been found to influence oligodendrocyte progenitor cell maturation (OPCs). | 27865736 |
| Traumatic AND/OR non-traumatic injury | Stem Cell Exhaustion | iPS-derived neural progenitor cells from PPMS patients reveal defect in myelin injury response. | 27865736 |
| Stomach Carcinoma | Stem Cell Exhaustion | However, peripheral levels of IL-23 were correlated with the absolute numbers of circulating populations of bone marrow-derived mesenchymal and very small embryonic/epiblast-like stem cells in patients with gastric carcinoma. | 27869179 |
| Multiple Myeloma | Stem Cell Exhaustion | Absence of spontaneous response improvement beyond day +100 after autologous stem cell transplantation in multiple myeloma. | 27869809 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | The response evaluation after autologous stem-cell transplantation (ASCT) is usually performed at day +100 in patients with multiple myeloma (MM). | 27869809 |
| Neoplasms, Relapsing course | Stem Cell Exhaustion | High-Dose Chemotherapy and Autologous Peripheral-Blood Stem-Cell Transplantation for Relapsed Metastatic Germ Cell Tumors: The Indiana University Experience. | 27870561 |
| Hypoxia, Reperfusion Injury | Stem Cell Exhaustion | We evaluated the role of donor age and hypoxia of human pediatric cardiac progenitor cell (CPC)-derived exosomes in a rat model of ischemia-reperfusion injury. | 27872050 |
| Morular Metaplasia of the Endometrium, Chemotherapy-induced nausea and vomiting, Multiple Myeloma, Chemotherapy-induced Nausea and Vomiting Questionnaire | Stem Cell Exhaustion | Chemotherapy-induced nausea and vomiting (CINV) is a significant side effect in multiple myeloma (MM) patients receiving high-dose melphalan treatment followed by autologous stem cell transplantation (ASCT). | 27873176 |
| Bone Marrow | Stem Cell Exhaustion | Furthermore, triplet regimen downregulated the expression of CXCR4, a chemokine receptor essential for bone marrow retention, on CD34+ cells, suggesting an unexpected effect on normal hematopoietic stem/progenitor cells through the reduced interaction with the bone marrow microenvironment. | 27873175 |
| Neoplasms | Stem Cell Exhaustion | There was no significant difference in MRI findings between pathologic tumor types (classical type versus stem cell feature type, P = 0.324-1.0). | 27875000 |
| NOTCH3 wt Allele | Stem Cell Exhaustion | We assessed plasma levels of von Willebrand factor (vWF) and thrombomodulin (TM) and the blood levels of endothelial progenitor cells (EPCs) and circulating progenitor cells (CPCs) in 49 CADASIL patients and 49 age-matched controls and their association with clinical/functional and neuroimaging features. | 27876311 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Using microbeads, CD133+ cells were isolated and were found to possess glioma stem cell properties. | 27878295 |
| Glioblastoma Multiforme Pathway, Neoplasms, Malignant Neoplasms | Stem Cell Exhaustion | Long non-coding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) significantly contributes to the progression of many human cancers, while glioma stem cells (GSCs) are believed to be responsible for tumor progression. | 27878295 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | We found higher NEAT1 RNA expression in CD133+ human glioma primary culture stem cells and CD133+ U87 cells via RT-PCR. | 27878295 |
| Primary amyloidosis | Stem Cell Exhaustion | Pre-transplantation novel agent induction predicts progression-free survival for patients with immunoglobulin light-chain amyloidosis undergoing high-dose melphalan and autologous stem cell transplantation. | 27879147 |
| Amyloidosis | Stem Cell Exhaustion | High-dose melphalan and autologous stem cell transplantation (HDM/SCT) is an effective treatment modality for immunoglobulin light-chain (AL) amyloidosis; however, its application remains restricted to patients with good performance status and limited organ involvement. | 27879147 |
| Ataxia Telangiectasia Mutated Proteins | Stem Cell Exhaustion | Integration-free erythroblast-derived human induced pluripotent stem cells (iPSCs) from an individual with Ataxia-Telangiectasia (A-T). | 27879207 |
| BCL2L1 gene | Stem Cell Exhaustion | Blood erythroid cells were briefly expanded in vitro and induced pluripotent stem cells (iPSCs) were generated via transfection with episomal vectors carrying hOCT4, hSOX2, hKLF4, hMYC and hBCL2L1. | 27879207 |
| Spastic Paraplegia, Hereditary | Stem Cell Exhaustion | Generation of induced pluripotent stem cells (iPSCs) from a hereditary spastic paraplegia patient carrying a homozygous R486C mutation in CYP7B1 (SPG5). | 27879216 |
| Optic Atrophy | Stem Cell Exhaustion | Generation of optic atrophy 1 patient-derived induced pluripotent stem cells (iPS-OPA1-BEHR) for disease modeling of complex optic atrophy syndromes (Behr syndrome). | 27879217 |
| Xanthomatosis | Stem Cell Exhaustion | Induced pluripotent stem cells (iPSCs) derived from cerebrotendinous xanthomatosis (CTX) patient's fibroblasts carrying a R395S mutation. | 27879219 |
| Xanthomatosis | Stem Cell Exhaustion | Induced pluripotent stem cells (iPSCs) were generated from dermal fibroblasts from a 60-year-old cerebrotendinous xanthomatosis (CTX) patient, carrying a homozygous mutation c. [1183C>A]; p. R395S in CYP27A1. | 27879219 |
| Spastic Paraplegia, Hereditary | Stem Cell Exhaustion | Generation of induced pluripotent stem cells (iPSCs) from a hereditary spastic paraplegia patient carrying a homozygous Y275X mutation in CYP7B1 (SPG5). | 27879220 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Sequential chemotherapy followed by reduced-intensity conditioning and allogeneic haematopoietic stem cell transplantation in adult patients with relapse or refractory acute myeloid leukaemia: a survey from the Acute Leukaemia Working Party of EBMT. | 27879990 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | This study analysed the outcome of 267 patients with relapse/refractory acute myeloid leukaemia (AML) who received sequential chemotherapy including fludarabine, cytarabine and amsacrine followed by reduced-intensity conditioning (RIC) and allogeneic haematopoietic stem cell transplantation (HSCT). | 27879990 |
| Disease remission | Stem Cell Exhaustion | Active disease came under control with this; however, the patient gradually developed limbal stem cell deficiency. | 27881591 |
| Anemia, Hemolytic, Decreased platelet count | Stem Cell Exhaustion | TA-TMA is a post-hematopoietic stem cell transplant complication with clinical features of hemolytic anemia and thrombocytopenia. | 27882637 |
| Mediastinal (Thymic) Large B-Cell Lymphoma | Stem Cell Exhaustion | Our aim was to retrospectively investigate the data from our institute the response rate and outcome in patients with primary mediastinal B-cell lymphoma (PMBL) who received the rituximab in combination with CHOP (RCHOP) followed by autologous stem cell transplantation (ASCT) or RCHOP followed by involved field radiation therapy (IFRT). | 27884092 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | Here, trophoblast cell surface antigen 2 (TROP2), a protein implicated in the regulation of stem cell activity, was examined in lung tissue samples from COPD patients. | 27887617 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | Abnormal airway regeneration observed in COPD is thought to originate in the stem/progenitor cells of the airway epithelium, the basal cells (BCs). | 27887617 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | Co-infusion of haplo-identical CD19-chimeric antigen receptor T cells and stem cells achieved full donor engraftment in refractory acute lymphoblastic leukemia. | 27887660 |
| BCR gene | Stem Cell Exhaustion | We treated a 71-year-old female with relapsed and refractory ALL who received co-infusion of haplo-identical donor-derived CD19-directed CAR-T cells and mobilized peripheral blood stem cells (PBSC) following induction chemotherapy. | 27887660 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | We previously completed a "first-in-human" clinical trial using in vitro expanded umbilical cord blood (UCB)-derived tTreg to prevent GVHD in patients undergoing UCB hematopoietic stem cell transplantation (HSCT). | 27887864 |
| Non-Neoplastic Hematologic and Lymphocytic Disorder | Stem Cell Exhaustion | Haploidentical stem cell transplantation (SCT) is increasingly used to treat pediatric patients with malignant or nonmalignant hematological disorders. | 27888540 |
| Bacteremia | Stem Cell Exhaustion | Vancomycin-Resistant Enterococcus Colonization and Bacteremia and Hematopoietic Stem Cell Transplantation Outcomes. | 27890428 |
| Vancomycin-Resistant Enterococci, Colonization | Stem Cell Exhaustion | The association between pre-hematopoietic stem cell transplantation (HSCT) vancomycin-resistant Enterococcus (VRE) colonization, HSCT-associated VRE bacteremia, and HSCT mortality is disputed. | 27890428 |
| Idiopathic Pulmonary Fibrosis | Stem Cell Exhaustion | Allogeneic Human Mesenchymal Stem Cells in Patients With Idiopathic Pulmonary Fibrosis via Intravenous Delivery (AETHER): A Phase I Safety Clinical Trial. | 27890713 |
| Idiopathic Pulmonary Fibrosis | Stem Cell Exhaustion | The Allogeneic Human Cells (hMSC) in patients with Idiopathic Pulmonary Fibrosis via Intravenous Delivery (AETHER) trial was the first study designed to evaluate the safety of a single infusion of bone marrow-derived mesenchymal stem cells in patients with idiopathic pulmonary fibrosis. | 27890713 |
| Idiopathic Pulmonary Fibrosis | Stem Cell Exhaustion | Nine patients with mild to moderate IPF were sequentially assigned to 1 of 3 cohorts and dosed with a single IV infusion of 20, 100, or 200 x 106 human bone marrow-derived mesenchymal stem cells per infusion from young, unrelated, men. | 27890713 |
| Idiopathic Pulmonary Fibrosis | Stem Cell Exhaustion | Data from this trial support the safety of a single infusion of human mesenchymal stem cells in patients with mild-moderate IPF. | 27890713 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease (GVHD) is a complication of allogeneic hematopoietic stem cell transplantation with high morbidity and mortality. | 27891662 |
| Dysautonomia, Familial | Stem Cell Exhaustion | To clarify the influence of exposure to a male fetus during a female donor's (FD) pregnancy in allogeneic hematopoietic stem cell transplantation (HSCT), we retrospectively examined 292 HSCT patients. | 27892749 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | This study aimed to analyze the use of the revised International Prognostic Scoring System (IPSS-R) assessed after hypomethylating treatment (HMT) for patients with myelodysplastic syndrome (MDS) undergoing an allogeneic stem cell transplantation (SCT). | 27892952 |
| Prostate carcinoma, Passive Cutaneous Anaphylaxis, Secondary malignant neoplasm of prostate | Stem Cell Exhaustion | Here we demonstrate for the first time that a microRNA component of this region-miR-383-is frequently downregulated in prostate cancer, has a critical role in determining tumor-initiating potential and is involved in prostate cancer metastasis via direct regulation of CD44, a ubiquitous marker of PCa tumor-initiating cells (TICs)/stem cells. | 27893706 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate. | 27894093 |
| Transcription Initiation, Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | Cancer stem cells (CSCs) play major roles in cancer initiation, metastasis, recurrence and therapeutic resistance. | 27894093 |
| Pituitary Adenoma | Stem Cell Exhaustion | Using a nanoString-based 80-gene custom codeset specific for developmental pathways, we identified a differential stem cell gene expression profile within human pituitary adenomas. | 27894339 |
| Adenoma | Stem Cell Exhaustion | Prospective functional characterization of stem cell properties in patient-derived adenomas representing all hormonal subtypes yielded a subtype-dependent self-renewal profile, which was enriched within the CD15+ cell fraction. | 27894339 |
| BRAF NP_004324.2:p.V600E, Disease | Stem Cell Exhaustion | Both diseases seem to be linked by a mutation in oncogenic BRAFV600E, probably an early event which occurs in bone marrow progenitor cells. | 27898473 |
| Virus Reactivation, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Prognostic impact of viral reactivations in acute myeloid leukemia patients undergoing allogeneic stem cell transplantation in first complete response. | 27902595 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Cytomegalovirus (CMV) serological status of donor and recipient as well as CMV reactivation have been associated with a lower risk of relapse in acute myeloid leukemia (AML) patients after allogeneic stem cell transplantation (alloSCT). | 27902595 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | To investigate the incidence, risk factors and survival of conjunctival acute graft-versus-host disease (aGVHD) in adult patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). | 27902756 |
| Paroxysmal nocturnal hemoglobinuria, PIGA gene | Stem Cell Exhaustion | We investigate clonal relationships of various NK-cell subsets, including the adaptive population, by taking advantage of naturally occurring X-linked somatic PIGA mutations in hematopoietic stem and progenitor cells (HSPCs) from patients with paroxysmal nocturnal hemoglobinuria (PNH). | 27903532 |
| Chronic active Epstein-Barr virus infection | Stem Cell Exhaustion | Successful Cord Blood Stem Cell Transplantation for an Adult Case of Chronic Active Epstein-Barr Virus Infection. | 27904117 |
| Chronic Epstein-Barr virus infection syndrome | Stem Cell Exhaustion | Chronic active Epstein-Barr virus (CAEBV) was diagnosed based on the findings of elevated EBV antibody titers and positive EBV-DNA in the peripheral blood, and cord blood stem cell transplantation (CBT) was performed. | 27904117 |
| Specialty Type - cancer | Stem Cell Exhaustion | Among studied proteins, there are some that are anti-apoptotic, pro-proliferative, cancer stem cell markers and the Vitamin D Receptor. | 27905097 |
| hepcidin, Hematologic Neoplasms | Stem Cell Exhaustion | We previously reported dynamic changes of serum hepcidin-25 levels in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 27905193 |
| Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Combination of anti-retroviral therapy, high-dose chemotherapy (HCT) and autologous stem cell transplantation (ASCT) has led to an improved survival of HIV+ non-Hodgkin lymphoma (NHL) patients. | 27905485 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Autologous stem cell transplantation for adult acute myelocytic leukemia in first remission-Better outcomes after busulfan and melphalan compared with busulfan and cyclophosphamide: A retrospective study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT). | 27906458 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Autologous stem cell transplantation (ASCT) for adult acute myelogenous leukemia (AML) is a valid therapeutic option for patients with good-risk and intermediate-risk disease. | 27906458 |
| Neoplasms | Stem Cell Exhaustion | The NOTCH signaling pathway may be involved in the survival of stem cell-like tumor-initiating cells and contribute to tumor growth. | 27906684 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Similar outcome after allogeneic stem cell transplantation with a modified FLAMSA conditioning protocol substituting 4 Gy TBI with treosulfan in an elderly population with high-risk AML. | 27909887 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The fludarabine, amsacrine, and cytarabine (FLAMSA)-reduced-intensity conditioning (RIC) protocol has been described to be effective in patients with high-risk and refractory acute myeloic leukemia (AML) undergoing allogeneic hematopoietic stem cell transplantation (aSCT). | 27909887 |
| Neutropenia, Infection | Stem Cell Exhaustion | Few studies have been performed to identify factors that are associated with an increased risk of infections during the neutropenic period in patients undergoing allogeneic stem cell transplantation (allo-SCT). | 27910184 |
| Deficiency | Stem Cell Exhaustion | Transplantation of in vitro cultured limbal epithelial stem cells (LESCs) is a treatment widely used for LESC deficiency. | 27911610 |
| Specialty Type - cancer, Neoplasms, Hypoxia | Stem Cell Exhaustion | HPV status, cancer stem cell marker expression, hypoxia gene signatures and tumour volume identify good prognosis subgroups in patients with HNSCC after primary radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG). | 27913065 |
| Hypoxia, Squamous cell carcinoma of the head and neck, Neoplasms, Specialty Type - cancer, NCI CTEP SDC Head and Neck Squamous Cell Carcinoma Sub-Category Terminology | Stem Cell Exhaustion | To investigate the impact of the tumour volume, HPV status, cancer stem cell (CSC) marker expression and hypoxia gene signatures, as potential markers of radiobiological mechanisms of radioresistance, in a contemporary cohort of patients with locally advanced head and neck squamous cell carcinoma (HNSCC), who received primary radiochemotherapy (RCTx). | 27913065 |
| Inflammation | Stem Cell Exhaustion | Patients presented inflammation syndrome and high levels of CXCL12, soluble stem cell factor and granulocyte colony-stimulating factor, whereas granulocyte macrophage colony-stimulating factor was low. | 27914820 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (HSCT) represents the cornerstone of treatment in pediatric high-risk and relapsed acute myeloid leukemia (AML). | 27916512 |
| 440 | Stem Cell Exhaustion | For 440 patients, bone marrow was used as stem cell source, and 191 patients received peripheral blood stem cells. | 27916512 |
| Tuberculosis | Stem Cell Exhaustion | Intestinal Pneumatosis Associated with Tuberculosis after Allogeneic Hematopoietic Stem Cell Transplantation. | 27923223 |
| Abdominal symptom, Fever, Multiple Myeloma | Stem Cell Exhaustion | Here, we report on a 56-year-old female with multiple myeloma who presented with undulating fever, fluctuating abdominal symptoms, and a distended abdomen 5 months after allogeneic hematopoietic stem cell transplantation (HSCT). | 27923223 |
| Disease remission, Specialty Type - cancer, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Outcomes of allogeneic stem cell transplantation among patients with acute myeloid leukemia presenting active disease: Experience of a single European Comprehensive Cancer Center. | 27925043 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (ASCT) representes a potentially curative approach for patients with relapsed or refractory acute myeloid leukemia (AML). | 27925043 |
| Malignant neoplasm of liver | Stem Cell Exhaustion | HBx drives alpha fetoprotein expression to promote initiation of liver cancer stem cells through activating PI3K/AKT signal pathway. | 27925189 |
| Hollings Cancer Center | Stem Cell Exhaustion | Altogether, HBx stimulates AFP expression to induce natural reprogramming of liver cells, and AFP plays a critical role in promoting the initiation of HCC progenitor/stem cells. | 27925189 |
| Up | Stem Cell Exhaustion | Here, we used induced pluripotent stem cells (iPSCs) derived from somatic cells of familial AD patients carrying PSEN1 mutations to study the early pathogenic event of AD. | 27926491 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | Prognosis of patients with peripheral T cell lymphoma who achieve complete response after CHOP/CHOP-like chemotherapy without autologous stem cell transplantation as an initial treatment. | 27928587 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | Because the long-term outcome of patients with PTCL, especially those achieving complete response (CR), has not been fully elucidated, we retrospectively analyzed 78 consecutive patients initially treated with CHOP/CHOP-like chemotherapy, without high-dose chemotherapy followed by autologous stem cell transplantation (HDC/auto-SCT). | 27928587 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | A 19-year-old male patient with acute myeloid leukemia received a human leukocyte antigen-haploidentical stem cell transplant as a second transplant while in second complete remission. | 27930567 |
| Pancreatitis | Stem Cell Exhaustion | After a second stem cell transplant, obstructive pancreatitis accompanied by a mass in the pancreatic head was observed. | 27930567 |
| Specialty Type - cancer, Malignant neoplasm of stomach, Neoplasms | Stem Cell Exhaustion | We examined the relationship between the presence of cancer stem cells (CSCs) at the invasive tumour front and prognosis in gastric cancer (GC). | 27931044 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Survival for transformed follicular lymphoma (tFL) has improved in the rituximab era and the need for upfront stem cell transplantation (SCT) is unclear. | 27931133 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | A 65-year-old man underwent peripheral blood stem cell transplantation (PBSCT) from his human leukocyte antigen (HLA)-haploidentical son for the treatment of acute myeloid leukemia, which had evolved from a myelodysplastic syndrome (MDS). | 27932186 |
| Moyamoya Disease | Stem Cell Exhaustion | Establishment of induced pluripotent stem cell (iPSC) line from 55-year old male patient with hemorrhagic Moyamoya disease. | 27934594 |
| Leukoencephalopathy | Stem Cell Exhaustion | Sequential Onset of Varicella-Zoster Virus Encephalomeningitis and Progressive Multifocal Leukoencephalopathy in an Allogeneic Hematopoietic Stem Cell Transplant Recipient. | 27938314 |
| herpesvirus 3, human, Leukoencephalopathy | Stem Cell Exhaustion | Here, we describe a case of sequential varicella-zoster virus encephalomeningitis and progressive multifocal leukoencephalopathy following an allogeneic hematopoietic stem cell transplant procedure. | 27938314 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | The gold standard in the diagnosis of gastrointestinal graft-versus-host disease (GVHD) after allogenic hematopoietic stem cell transplantation is conventional endoscopy with histopathological assessment. | 27941359 |
| Fatigue, Depression, CTCAE, Cognitive problems | Stem Cell Exhaustion | Cognitive problems following hematopoietic stem cell transplant: relationships with sleep, depression and fatigue. | 27941775 |
| Cognitive problems | Stem Cell Exhaustion | Cognitive problems are a significant, persistent concern for patients undergoing hematopoietic stem cell transplant (HSCT). | 27941775 |
| Prolymphocytic Leukemia | Stem Cell Exhaustion | Allogeneic stem cell transplantation (alloSCT) is used for treating patients with T-prolymphocytic leukemia (T-PLL). | 27941777 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Pre-transplant persistence of minimal residual disease does not contraindicate allogeneic stem cell transplantation for adult patients with acute myeloid leukemia. | 27941782 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | To test the feasibility of mycophenolate mofetil (MMF) for graft-versus-host disease (GVHD) prophylaxis in Japanese patients, we conducted two multicenter prospective phase II trials of allogeneic hematopoietic stem-cell transplantation (HSCT) from HLA-matched related donors (MRD group) with MMF and cyclosporine or HLA 7-8/8 allele-matched unrelated bone-marrow donors (URD group) with MMF and tacrolimus. | 27943166 |
| Clostridium difficile colitis | Stem Cell Exhaustion | Risk factors and epidemiology of Clostridium difficile infection in hematopoietic stem cell transplant recipients during the peritransplant period. | 27943501 |
| Clostridium difficile, Central Diabetes Insipidus, Communicable Diseases | Stem Cell Exhaustion | Hematopoietic stem cell transplant (HSCT) recipients represent a high-risk group for developing Clostridium difficile (CD) infection (CDI). | 27943501 |
| Ulcer | Stem Cell Exhaustion | The medial ulcer was treated with transplantation of autologous adipose mesenchymal stem cell (AMSC)-enriched, high-density lipoaspirate (HDL) on OASIS wound matrix and compression therapy. | 27943665 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | Although shorter LTL is associated with decreased regenerative capacity, both LTL and circulating progenitor cell levels are independent and additive predictors of adverse cardiovascular outcomes in coronary artery disease patients. | 27956416 |
| Neurodegenerative Disorders | Stem Cell Exhaustion | Engulfment of synapses and neural progenitor cells (NPCs) by microglia is critical for the development and maintenance of proper brain circuitry, and has been implicated in neurodevelopmental as well as neurodegenerative disease etiology. | 27956744 |
| Chronic heart failure | Stem Cell Exhaustion | The effect of serum on the proliferation of bone marrow-derived mesenchymal stem cells from aged donors and donors with or without chronic heart failure. | 27957821 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Bismuth adjuvant ameliorates adverse effects of high-dose chemotherapy in patients with multiple myeloma and malignant lymphoma undergoing autologous stem cell transplantation: a randomised, double-blind, prospective pilot study. | 27966023 |
| Neutropenia, Bacteremia, Gastrointestinal mucositis | Stem Cell Exhaustion | High-dose chemotherapy prior to autologous stem cell transplantation (ASCT) leads to adverse effects including mucositis, neutropenia and bacteremia. | 27966023 |
| glycation | Stem Cell Exhaustion | Pre-existing Kr5+ progenitor cells produced squamous alveolar cells expressing receptor for advanced glycation endproducts, aquaporin 5, and T1a in alveoli devoid of AEC2s. | 27967234 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Consolidation with autologous stem cell transplantation in first remission is safe and effective in AML patients above 65 years. | 27978458 |
| Neuromuscular, Injury of sciatic nerve | Stem Cell Exhaustion | Human Induced Pluripotent Stem Cell-Derived Motor Neuron Transplant for Neuromuscular Atrophy in a Mouse Model of Sciatic Nerve Injury. | 27978547 |
| gastrointestinal, Communicable Diseases | Stem Cell Exhaustion | Objective Conditioning regimens for hematopoietic stem cell transplantation (HSCT) are well known to cause severe gastrointestinal toxicities that often disturb the oral intake of the patients followed by poor nutrition and life-threatening infection. | 27980254 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Relevance of prognostic factors in the decision-making of stem cell transplantation in Myelodysplastic Syndromes. | 27982317 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | The hematopoietic stem cell transplantation (HSCT) is the only curative alternative for Myelodysplastic Syndrome (MDS), but many patients are not eligible for this treatment, as there are several limiting factors, especially in the case of patients with low-risk MDS. | 27982317 |
| Chemosensitivity, Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | Rituximab-containing salvage chemotherapy followed by high-dose therapy and autologous stem cell transplant (ASCT) in chemosensitive patients remains the standard of care for patients with relapsed and refractory diffuse large B-cell lymphoma (DLBCL). | 27982423 |
| Fracture, Degenerative polyarthritis | Stem Cell Exhaustion | Differential analysis of genome-wide methylation and gene expression in mesenchymal stem cells of patients with fractures and osteoarthritis. | 27982725 |
| Multiple Myeloma | Stem Cell Exhaustion | Risk stratification in myeloma by detection of circulating plasma cells prior to autologous stem cell transplantation in the novel agent era. | 27983726 |
| Multiple Myeloma | Stem Cell Exhaustion | The impact of circulating plasma cells (CPCs) prior to autologous stem cell transplantation (ASCT) for multiple myeloma has not been defined in the novel agent era. | 27983726 |
| leukemia | Stem Cell Exhaustion | Graft-Versus-Host Disease in Adolescents and Young Adults (15-24 Years Old) After Allogeneic Hematopoietic Stem Cell Transplantation for Acute Leukemia in First Complete Remission. | 27983886 |
| Graft-vs-Host Disease, Acute leukemia | Stem Cell Exhaustion | This study aims to correlate the risk of graft-versus-host disease (GvHD) and age in a population of children and young adults with acute leukemia undergoing hematopoietic stem cell transplantation (HSCT) in first complete remission (CR). | 27983886 |
| Hodgkin Disease | Stem Cell Exhaustion | A multi-institutional analysis of peritransplantation radiotherapy in patients with relapsed/refractory Hodgkin lymphoma undergoing autologous stem cell transplantation. | 27984652 |
| Hodgkin Disease, LIPC gene | Stem Cell Exhaustion | No consensus exists regarding the use of radiotherapy (RT) in conjunction with high-dose chemotherapy and autologous stem cell transplantation (HDC/ASCT) for patients with relapsed/refractory classical Hodgkin lymphoma (HL). | 27984652 |
| Rhizomucor | Stem Cell Exhaustion | Cerebral Rhizomucor Infection Treated by Posaconazole Delayed-Release Tablets in an Allogeneic Stem Cell Transplant Recipient. | 27988409 |
| Zygomycosis, Mycoses | Stem Cell Exhaustion | Mucormycosis (zygomycosis) is an emerging fungal disease in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients. | 27988409 |
| Angioendotheliomatosis | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplantation for intravascular large B-cell lymphoma: the European Society for Blood and Marrow Transplantation experience. | 27991887 |
| Neoplasms | Stem Cell Exhaustion | Tissue-based chimerism analysis enhances detection of donor-derived neoplasia in allogeneic stem cell transplant patients. | 27991892 |
| Childhood Breast Carcinoma, Secondary Neoplasm | Stem Cell Exhaustion | The expression of EVI1 and SOX9 is associated with stem cell-like and metastasis signatures, and their depletion impairs the metastatic potential of breast cancer cells. | 27991928 |
| Medial collateral ligament, Mantle cell lymphoma | Stem Cell Exhaustion | Aggressive induction chemotherapy followed by autologous haematopoietic stem cell transplant (auto-HCT) is effective for younger patients with mantle cell lymphoma (MCL). | 27992063 |
| Aggressive behavior, Neoplasms | Stem Cell Exhaustion | Furthermore, activation of this latter lipid network has been recently demonstrated to confer invasive and stem cell properties to tumor cells promoting tumor aggressiveness and patient relapse. | 27992526 |
| Hyperglycemia, Diabetes | Stem Cell Exhaustion | Impact of Hyperglycemia and Low Oxygen Tension on Adipose-Derived Stem Cells Compared with Dermal Fibroblasts and Keratinocytes: Importance for Wound Healing in Type 2 Diabetes. | 27992567 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Adipose-derived stem cells (ASC) are currently proposed for wound healing in those with type 2 diabetes mellitus (T2DM). | 27992567 |
| Aggressive Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Treatment outcomes for older patients with relapsed/refractory aggressive lymphoma receiving salvage chemotherapy and autologous stem cell transplantation are similar to younger patients: a subgroup analysis from the phase III CCTG LY.12 trial. | 27993811 |
| Aggressive Non-Hodgkin Lymphoma | Stem Cell Exhaustion | High-dose therapy and autologous stem cell transplantation (ASCT) is often considered for older patients (age >60 years) with relapsed/refractory aggressive lymphomas. | 27993811 |
| Childhood Breast Carcinoma, Triple-Negative Breast Cancer Finding | Stem Cell Exhaustion | Evaluation of Breast Cancer Stem Cells and Intratumor Stemness Heterogeneity in Triple-negative Breast Cancer as Prognostic Factors. | 27994520 |
| Aggressive behavior, Childhood Breast Carcinoma | Stem Cell Exhaustion | Breast cancer stem cells (BCSCs) have been suggested to have tumor-initiating properties, but it remains unclear whether their presence contributes to the increased aggressiveness and poor prognosis of TNBC. | 27994520 |
| Lymphoma | Stem Cell Exhaustion | Late Relapses After High-dose Chemotherapy and Autologous Stem Cell Transplantation in Patients With Diffuse Large B-cell Lymphoma in the Rituximab Era. | 27998707 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | The standard of care for diffuse large B-cell lymphoma (DLBCL) relapsing after front-line therapy is high-dose chemotherapy and autologous stem cell transplantation (ASCT). | 27998707 |
| Non-Small Cell Lung Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | CD133 is a widely used cancer stem cell (CSC) marker, and CD133-positive cancer cells are thought to be tumor-initiating cells with CSC characteristics, while CXCR4, a stromal-derived-factor-1 specific chemokine receptor, is highly expressed in NSCLC tissues and participates in cancer progression by regulating cell anti-apoptosis. | 28000861 |
| Acute Promyelocytic Leukemia | Stem Cell Exhaustion | Here, the mechanism of TSY-1 on cellular Telomerase activity was further investigated using HL60, a promyelocytic leukemia cell line, normal peripheral blood mononuclear cells, and CD34+ hematopoietic stem cells derived from umbilical cord blood. | 28002788 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Central Nervous System Involvement at the Time of Allogeneic Hematopoietic Stem Cell Transplantation Is Associated with a Poor Outcome in Patients with Acute Myeloid Leukemia. | 28004352 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Recent reports suggested that central nervous system (CNS) involvement (CNS+) in patients with acute myeloid leukemia (AML) before allogeneic hematopoietic stem cell transplantation (allo-HSCT) is not an independent predictor of survival after allo-HSCT. | 28004352 |
| physiopathological, Chronic Kidney Disease, CTCAE | Stem Cell Exhaustion | Indoxyl Sulfate Impairs Endothelial Progenitor Cells and Might Contribute to Vascular Dysfunction in Patients with Chronic Kidney Disease. | 28006782 |
| Hodgkin Disease, Lymphoma | Stem Cell Exhaustion | Myeloablative versus reduced intensity allogeneic stem cell transplantation for relapsed/refractory Hodgkin's lymphoma in recent years: a retrospective analysis of the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation. | 28007754 |
| Hodgkin Disease, LIPC gene | Stem Cell Exhaustion | To evaluate long-term outcome of myeloablative allogeneic stem cell transplantation (allo-SCT) (MAC) versus reduced-intensity allo-SCT (RIC) in patients with relapsed/refractory Hodgkin's lymphoma (HL) in recent years. | 28007754 |
| Specialty Type - cancer | Stem Cell Exhaustion | Spheroid colony formation is used to characterize cancer stem cell (CSCs). | 28011472 |
| Specialty Type - cancer, Squamous cell carcinoma | Stem Cell Exhaustion | Podoplanin is a candidate cancer stem cell marker in squamous cell carcinoma (SCC). | 28011493 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Stable breast cancer cell (BCC) lines are valuable tools for the identification of breast cancer stem cell (BCSC) phenotypes that develop in response to several stimuli as well as for studying the basic mechanisms associated with the initiation and maintenance of BCSCs. | 28012234 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | We isolated BCSCs with high ALDH activity (CD44+ /CD24- /Aldefluorpos ) from a primary culture of human breast cancer tissue and observed that the cells had stem cell properties compared to BCSCs with no ALDH activity (CD44+ /CD24- /Aldefluorneg ). | 28012234 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Hypoxia promotes the phenotypic change of aldehyde dehydrogenase activity of breast cancer stem cells. | 28012234 |
| Aplastic Anemia, CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology | Stem Cell Exhaustion | Severe aplastic anemia (SAA) is a life-threatening hematopoietic stem cell disorder that is treated with bone marrow transplantation (BMT) or immunosuppressive therapy (IST). | 28013015 |
| Multiple Myeloma | Stem Cell Exhaustion | Comparison of engraftment following different stem cell mobilization modalities in patients with multiple myeloma treated with a uniform induction regimen containing bortezomib, cyclophosphamide and dexamethasone. | 28013359 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Bortezomib-based induction followed by autologous stem cell transplantation is a common treatment for multiple myeloma (MM). | 28013359 |
| Multiple Myeloma | Stem Cell Exhaustion | Bortezomib with lenalidomide and dexamethasone versus lenalidomide and dexamethasone alone in patients with newly diagnosed myeloma without intent for immediate autologous stem-cell transplant (SWOG S0777): a randomised, open-label, phase 3 trial. | 28017406 |
| Multiple Myeloma | Stem Cell Exhaustion | We aimed to study whether the addition of bortezomib to lenalidomide and dexamethasone would improve progression-free survival and provide better response rates in patients with previously untreated multiple myeloma who were not planned for immediate autologous stem-cell transplant. | 28017406 |
| Infection | Stem Cell Exhaustion | The occurrence of infections after allogeneic hematopoietic stem cell transplantation (HCT) is nearly universal. | 28017733 |
| leukemia, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Ex Vivo CD34+-Selected T Cell-Depleted Peripheral Blood Stem Cell Grafts for Allogeneic Hematopoietic Stem Cell Transplantation in Acute Leukemia and Myelodysplastic Syndrome Is Associated with Low Incidence of Acute and Chronic Graft-versus-Host Disease and High Treatment Response. | 28017734 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Ex vivo CD34+-selected T cell depletion (TCD) has been developed as a strategy to reduce the incidence of graft-versus-host disease (GVHD) after allogeneic (allo) hematopoietic stem cell transplantation (HSCT). | 28017734 |
| Heart failure | Stem Cell Exhaustion | Patients with symptomatic ischaemic heart failure on guideline-directed therapy (n = 484) were screened; n = 348 underwent bone marrow harvest and mesenchymal stem cell expansion. | 28025189 |
| Shock, Cardiogenic | Stem Cell Exhaustion | Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. | 28025189 |
| Alzheimers Disease | Stem Cell Exhaustion | Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. | 28025562 |
| Neurodegenerative Disorders, Up, "Alzheimers Disease | Stem Cell Exhaustion | Mesenchymal stem cells (MSCs) have emerged as a promising tool for the treatment of several neurodegenerative disorders, including Alzheimer's disease (AD). | 28025562 |
| Dental Surface Disorder | Stem Cell Exhaustion | Allogenic cultivated limbal stem cell transplantation versus cadaveric keratolimbal allograft in ocular surface disorder: 1-year outcome. | 28025793 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | We recently reported that peroxisome proliferator-activated receptor g agonists target chronic myeloid leukemia (CML) quiescent stem cells in vitro by decreasing transcription of STAT5. | 28026860 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Adipocytes are derived from adipose-derived stem cells and express adipocytokines that can facilitate active breast cancer cells in laboratory models. | 28027219 |
| Hepatitis B | Stem Cell Exhaustion | Hepatitis B reactivation in occult viral carriers undergoing hematopoietic stem cell transplantation: A prospective study. | 28027590 |
| Hepatitis B | Stem Cell Exhaustion | Hepatitis B virus (HBV) reactivation in hepatitis B surface antigen (HBsAg)-negative, antibody to hepatitis B core antigen (anti-HBc)-positive patients after allogeneic hematopoietic stem cell transplantation (HSCT) has not been prospectively studied. | 28027590 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | Purpose We compared the efficacy of ofatumumab (O) versus rituximab (R) in combination with cisplatin, cytarabine, and dexamethasone (DHAP) salvage treatment, followed by autologous stem-cell transplantation (ASCT) in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). | 28029326 |
| Hypertrophy, Specialty Type - cancer | Stem Cell Exhaustion | growth arrest, hypertrophy, poliploidization and secretory phenotype) and certain properties of cancer stem cells (increased NANOG expression, percentages of CD24+ cells and side population). | 28030837 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Stem cell gene signatures predict poor prognosis in AML patients; however, with few exceptions, these deregulated molecular pathways cannot be targeted therapeutically. | 28031480 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | CD70/CD27 signaling in AML cells activates stem cell gene expression programs, including the Wnt pathway, and promotes symmetric cell divisions and proliferation. | 28031480 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | In this study, we demonstrate that the TNF superfamily ligand-receptor pair CD70/CD27 is expressed on AML blasts and AML stem/progenitor cells. | 28031480 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Blocking the CD70/CD27 interaction by mAb induced asymmetric cell divisions and differentiation in AML blasts and AML stem/progenitor cells, inhibited cell growth and colony formation, and significantly prolonged survival in murine AML xenografts. | 28031480 |
| Infection | Stem Cell Exhaustion | Infections due to alphaherpesviruses in early post-transplant period after allogeneic haematopoietic stem cell transplantation: Results of a 5-year survey. | 28033514 |
| Lymphoma, Relapsing course | Stem Cell Exhaustion | Relapsed or Refractory Double-Expressor and Double-Hit Lymphomas Have Inferior Progression-Free Survival After Autologous Stem-Cell Transplantation. | 28034071 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Molecular Monitoring after Autologous Stem Cell Transplantation and Preemptive Rituximab Treatment of Molecular Relapse; Results from the Nordic Mantle Cell Lymphoma Studies (MCL2 and MCL3) with Median Follow-Up of 8.5 Years. | 28039078 |
| Lymphoma | Stem Cell Exhaustion | Among the patients enrolled in 2 prospective trials by the Nordic Lymphoma Group, 183 who had completed autologous stem cell transplantation (ASCT) and in whom an MRD marker had been obtained were included in our analysis. | 28039078 |
| Fatigue, Specialty Type - cancer | Stem Cell Exhaustion | Intensive cancer treatment followed by hematopoietic stem cell transplantation (HCT) results in moderate to severe fatigue and physical inactivity, leading to diminished functional ability. | 28042020 |
| Anterior Cruciate Ligament Injuries | Stem Cell Exhaustion | Viable stem cells are mobilized to the postinjury effusion at the time of cruciate ligament injury and can be found in the byproduct waste of cruciate ligament surgery. | 28043750 |
| RAB27A gene, Malignant neoplasm of ovary | Stem Cell Exhaustion | MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A. | 28043921 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | One of these miRNAs is miR-134-3p, and its expression changes significantly in human ovarian cancer stem cells (OCSCs) and in CD44-/CD133- ovarian cancer. | 28043921 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | Topical Recombinant Human Epidermal Growth Factor for Oral Mucositis Induced by Intensive Chemotherapy with Hematopoietic Stem Cell Transplantation: Final Analysis of a Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial. | 28045958 |
| Gastrointestinal mucositis, Oman | Stem Cell Exhaustion | The aim of this study was to evaluate the efficacy and safety of recombinant human epidermal growth factor (rhEGF) oral spray for oral mucositis (OM) induced by intensive chemotherapy with hematopoietic stem cell transplantation. | 28045958 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells (CSCs) are thought to be the "root" of cancer. | 28046028 |
| Specialty Type - cancer | Stem Cell Exhaustion | Assessments were made from the pretreatment phase of transplantation to after the end of parenteral nutrition in 51 patients who underwent allogeneic stem cell transplantation at Shizuoka Cancer Center between 2007 and 2012. | 28050676 |
| Weight decreased | Stem Cell Exhaustion | Early and customized nutritional intervention may be optimal for all patients who undergo allogeneic stem cell transplantation to ameliorate body weight loss associated with nutrition-related adverse events. | 28050676 |
| Multiple Myeloma | Stem Cell Exhaustion | Autologous stem cell transplantation for multiple myeloma: Long-term results. | 28050994 |
| Polyneuropathy | Stem Cell Exhaustion | In vitro modelling of familial amyloidotic polyneuropathy allows quantitative detection of transthyretin amyloid fibril-like structures in hepatic derivatives of patient-specific induced pluripotent stem cells. | 28051995 |
| Leukemia, Myelocytic, Acute, Acute leukemia | Stem Cell Exhaustion | Impact of FAB classification on predicting outcome in acute myeloid leukemia, not otherwise specified, patients undergoing allogeneic stem cell transplantation in CR1: An analysis of 1690 patients from the acute leukemia working party of EBMT. | 28052366 |
| Leukemia, Myelocytic, Acute, NPM1 wt Allele | Stem Cell Exhaustion | While recent data proposes that FAB classification does not provide additional prognostic information for patients for whom NPM1 status is available, it is unknown whether FAB still retains a current prognostic role in predicting outcome of AML patients undergoing allogeneic stem cell transplantation. | 28052366 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Relapse risk and survival in patients with FLT3 mutated acute myeloid leukemia undergoing stem cell transplantation. | 28052408 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | In patients with AML with FMS-like tyrosine kinase 3 (FLT3) mutations, the significance of minimal residual disease (MRD) detected by PCR before allogeneic stem cell transplantation (SCT) on outcomes after transplant remains unclear. | 28052408 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Acute graft-versus-host disease (GVHD) is the major treatment-related complication after stem-cell transplantation (SCT) from unrelated-donors. | 28052467 |
| Chronic heart failure | Stem Cell Exhaustion | Safety, feasibility and effectiveness of first in-human administration of muscle-derived stem/progenitor cells modified with connexin-43 gene for treatment of advanced chronic heart failure. | 28052545 |
| Heart failure | Stem Cell Exhaustion | To assess the safety and efficacy of transendocardial delivery of muscle-derived stem/progenitor cells with connexin-43 overexpression (Cx-43-MDS/PC) in advanced heart failure (HF). | 28052545 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Patients ranged in age from 2 months to 71 years and 80% had hematologic malignancy or were bone marrow or hematopoietic stem cell transplant recipients. | 28054734 |
| PAFAH1B1 wt Allele, REG1CP gene | Stem Cell Exhaustion | Significant better RS was found for younger compared to older higher-risk MDS patients (48% vs. 17%), reflecting the effect of allogeneic hematopoietic stem-cell transplantation. | 28056392 |
| Sarcoma, Myeloid | Stem Cell Exhaustion | Clinical outcome of myeloid sarcoma in adult patients and effect of allogeneic stem cell transplantation. | 28056398 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 28057639 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Outcome of allogeneic hematopoietic stem cell transplantation in adult patients with acute myeloid leukemia harboring trisomy 8. | 28058493 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | However, the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) in adult patients with AML harboring +8 remains unclear. | 28058493 |
| Hematologic Neoplasms, Diabetes, Acute leukemia | Stem Cell Exhaustion | Maximum glucose was a predictor of hospital length of stay among patients without diabetes (but not those with diabetes), and with acute leukemia or stem cell transplant (but not other hematologic malignancies). | 28058528 |
| Hematologic Neoplasms, Diabetes | Stem Cell Exhaustion | Maximum glucose was a predictor of length of stay but this was only significant for patients without diabetes, those with acute hematologic malignancy or stem cell transplant. | 28058528 |
| spinal defect | Stem Cell Exhaustion | Omniscan (gadodiamide) magnetic resonance imaging tractography was analyzed to assess the spinal defects and the improvement by human embryonic stem cell treatment. | 28058985 |
| Spinal Cord Injuries | Stem Cell Exhaustion | Magnetic resonance imaging tractography as a diagnostic tool in patients with spinal cord injury treated with human embryonic stem cells. | 28058985 |
| Spinal Cord Diseases | Stem Cell Exhaustion | Spinal disorders have been treated with human embryonic stem cells. | 28058985 |
| Spinal Cord Injuries | Stem Cell Exhaustion | The present study was conducted to evaluate the diagnostic modality of magnetic resonance imaging tractography to determine the efficacy of human embryonic stem cells in chronic spinal cord injury. | 28058985 |
| Malignant neoplasm of liver | Stem Cell Exhaustion | Shp2 promotes liver cancer stem cell expansion by augmenting b-catenin signaling and predicts chemotherapeutic response of patients. | 28059452 |
| Specialty Type - cancer | Stem Cell Exhaustion | Src-homology 2 domain-containing phosphatase 2 (Shp2) has been reported to play an important role in the maintenance and self-renewal of embryonic and adult stem cells, but its role in cancer stem cells (CSCs) remains obscure. | 28059452 |
| Graft-vs-Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | To validate the International Chronic Ocular GVHD Consensus Group (ICCGVHD) diagnostic criteria for chronic ocular chronic graft-versus-host disease (GVHD), by comparing results with comprehensive ophthalmic evaluation after allogeneic hematopoietic stem cell transplantation. | 28060078 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Increased Proangiogenic Activity of Mobilized CD34+ Progenitor Cells of Patients With Acute ST-Segment-Elevation Myocardial Infarction: Role of Differential MicroRNA-378 Expression. | 28062497 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Proangiogenic effects of mobilized bone marrow-derived stem/progenitor cells are essential for cardiac repair after myocardial infarction. | 28062497 |
| Electrocardiogram: myocardial infarction (finding), Coronary Arteriosclerosis | Stem Cell Exhaustion | We investigated the differential regulation of angio-miRs, that is, miRNAs regulating neovascularization, in mobilized CD34+ progenitor cells obtained from patients with an acute ST-segment-elevation myocardial infarction (STEMI) as compared with those with stable coronary artery disease or healthy subjects. | 28062497 |
| Coronary Arteriosclerosis | Stem Cell Exhaustion | CD34+ progenitor cells were isolated from patients with STEMI (on day 0 and day 5), stable coronary artery disease, and healthy subjects (n=27). | 28062497 |
| Acute myocardial infarction | Stem Cell Exhaustion | The increased proangiogenic activity of these cells in patients with STEMI and the observation that in particular miR-378 regulates the angiogenic capacity of CD34+ progenitor cells in vivo suggest that this unique miRNA expression pattern represents a novel endogenous repair mechanism activated in acute myocardial infarction. | 28062497 |
| Comorbidity | Stem Cell Exhaustion | Outcome after allogeneic hematopoietic stem cell transplantation is influenced by patient comorbidity, disease type, and status before treatment. | 28063962 |
| Hematologic Neoplasms | Stem Cell Exhaustion | We performed a retrospective study involving 521 consecutive adult hematopoietic stem cell transplantation patients who underwent transplantation for hematological malignancy at our center from 2000 to 2012 to compare the predictive value of the hematopoietic cell transplantation-specific comorbidity index (HCT-CI) and the disease risk index (DRI) for overall survival and transplantation-related mortality. | 28063962 |
| Hepatitis B | Stem Cell Exhaustion | Impact of Hepatitis B Core Antibody Seropositivity on the Outcome of Autologous Hematopoietic Stem Cell Transplantation for Multiple Myeloma. | 28063964 |
| skeletal muscle cell proliferation | Stem Cell Exhaustion | Furthermore, Ang II inhibits skeletal muscle stem cell proliferation, leading to lowered muscle regenerative capacity. | 28066057 |
| Lymphoma | Stem Cell Exhaustion | In an otherwise eligible patient with relapsed lymphoma, inadequate mobilization of hematopoietic stem cells (HSCs) is a limiting factor to proceeding with an autologous hematopoietic cell transplantation (auto-HCT). | 28067870 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The clinical outcome of primary refractory (PRF) AML patients is poor and only a minor proportion of patients is rescued by allogenic hematopoietic stem cell transplantation (HSCT). | 28067875 |
| Lymphoma | Stem Cell Exhaustion | Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma. | 28068180 |
| Therapy-related acute myeloid leukemia and myelodysplastic syndrome, Lymphoma, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | We hypothesized that in patients undergoing autologous stem-cell transplantation (ASCT) for lymphoma, CHIP at the time of ASCT would be associated with an increased risk of myelodysplastic syndrome and acute myeloid leukemia, collectively termed therapy-related myeloid neoplasm (TMN), and other adverse outcomes. | 28068180 |
| Hodgkin Disease, Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Methods We performed whole-exome sequencing on pre- and post-ASCT samples from 12 patients who developed TMN after autologous transplantation for Hodgkin lymphoma or non-Hodgkin lymphoma and targeted sequencing on cryopreserved aliquots of autologous stem-cell products from 401 patients who underwent ASCT for non-Hodgkin lymphoma between 2003 and 2010. | 28068180 |
| Keratitis, DLST wt Allele, Photophobia | Stem Cell Exhaustion | The first DLT, grade 3 photophobia, occurred at 4.34 mg/kg and two additional DLTs, grade 2 keratitis and grade 1 limbal stem cell deficiency (> 2-week dosing delay), at 6.5 mg/kg. | 28070718 |
| Pituitary Adenoma | Stem Cell Exhaustion | The histogenesis of the adipose element in pituitary adenoma is not well understood, and could be a result of a metaplastic change or divergent differentiation from a common progenitor cell. | 28070930 |
| Graft-vs-Host Disease, Communicable Diseases | Stem Cell Exhaustion | Infection, relapse, and GVHD can complicate allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 28073320 |
| Lymphoma | Stem Cell Exhaustion | Safety and efficacy of allogeneic hematopoietic stem cell transplant after PD-1 blockade in relapsed/refractory lymphoma. | 28073785 |
| Mycosis Fungoides | Stem Cell Exhaustion | Donor-derived mycosis fungoides following reduced intensity haematopoietic stem cell transplantation from a matched unrelated donor. | 28073814 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | A 46-year-old woman with a history of dasatinib-resistant chronic myeloid leukaemia, clonal evolution and monosomy 7 underwent reduced intensity conditioned in vivo T-cell-depleted allogeneic haematopoietic stem cell transplantation (HSCT) from a matched unrelated donor. | 28073814 |
| PAFAH1B1 wt Allele, Dysplasia, Cytopenia, Myeloid, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | The myelodysplastic syndrome (MDS) comprises a group of clonal hematopoietic stem cell diseases characterized by cytopenia, dysplasia in one or more of the major myeloid lineages, ineffective hematopoiesis, and increased risk of development of acute myeloid leukemia (AML). | 28074192 |
| Neoplasms | Stem Cell Exhaustion | We speculate that migration of defective neural crest stem cells along both upper limb buds during embryogenesis may have allowed these essentially identical tumors to arise in similar locations bilaterally simultaneously. | 28075051 |
| Malignant neoplasm of lung | Stem Cell Exhaustion | We demonstrate miR-410 increases the levels of stem cells marker Sox2, Oct4, Nanog, CXCR4 as well as lung cancer stem cells surface marker CD44 and CD166. | 28076327 |
| Secondary Neoplasm | Stem Cell Exhaustion | MiR-410 promotes stem cells-like properties such as proliferation, sphere formation, metastasis and chemoresistance. | 28076327 |
| Specialty Type - cancer | Stem Cell Exhaustion | We demonstrated that PDHA1 gene KO significantly decreased mitochondrial OXPHOS and promoted anaerobic glycolysis, accompanied with higher stemness phenotype including resistance to chemotherapy, enhanced migration ability and increased expression of cancer stem cell markers. | 28076853 |
| Lymphoma | Stem Cell Exhaustion | Few studies have assessed bone health in lymphoma survivors treated with high-dose therapy with autologous stem cell transplantation (HDT-ASCT). | 28077016 |
| Febrile Neutropenia, Malignant Neoplasms | Stem Cell Exhaustion | Patients were >18 years old with febrile neutropenia (neutrophil count <500 cells/mm3 and temperature >38.0oC) and received chemotherapy or stem cell transplant as treatment for malignancy. | 28077047 |
| Respiratory Syncytial Virus Infections, Allogeneic Hematopoietic Stem Cell Transplant Recipient | Stem Cell Exhaustion | Effective use of oral ribavirin for respiratory syncytial viral infections in allogeneic haematopoietic stem cell transplant recipients. | 28077243 |
| Viral respiratory infection | Stem Cell Exhaustion | Respiratory syncytial virus (RSV) is a frequent cause of respiratory viral infections, increasing the morbidity and mortality in allogeneic haematopoietic stem cell transplantation (HSCT) recipients. | 28077243 |
| Pituitary Adenoma | Stem Cell Exhaustion | In this sense, it is proposed that stem cell could be involved in pituitary adenoma tumorigenesis. | 28078618 |
| Blast Injuries | Stem Cell Exhaustion | Traumatized muscle, such as that debrided from blast injury sites, is considered a promising and convenient tissue source for multipotent progenitor cells (MPCs), a population of adult mesenchymal stem cell (MSC)-like cells. | 28078807 |
| Fabry Disease | Stem Cell Exhaustion | Energy utilization of induced pluripotent stem cell-derived cardiomyocyte in Fabry disease. | 28082092 |
| Cardiomyopathies, Fabry Disease, Dysautonomia, Familial | Stem Cell Exhaustion | We aimed to generate patient-specific induced pluripotent stem cells (iPSC) from FD patients presenting cardiomyopathy to determine whether the model could recapitulate key features of the disease phenotype and to investigate the energy metabolism in Fabry disease. | 28082092 |
| Prostate carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Co-Expression of Putative Cancer Stem Cell Markers CD44 and CD133 in Prostate Carcinomas. | 28083789 |
| Specialty Type - cancer, Secondary Neoplasm, Neoplastic Cell Transformation | Stem Cell Exhaustion | Cancer stem cells (CSCs) are the main players of prostate tumorigenesis thus; characterization of CSCs can pave the way for understanding the early detection, drug resistance, metastasis and relapse. | 28083789 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | Stem-like subpopulations of cancer cells show high migratory and metastatic capacity, thus we hypothesize that breast cancer stem cell markers evaluation in metastasized lymph nodes could provide a more accurate prediction of patient's prognosis. | 28084338 |
| Childhood Breast Carcinoma, Neoplasms | Stem Cell Exhaustion | Therefore, the expression profile of P-cadherin, CD44, and CD49f, which have been already associated to stem cell properties in breast cancer, has been evaluated by immunohistochemistry in a series of 135 primary tumors and matched axillary lymph node metastases from 135 breast cancer patients. | 28084338 |
| FLT3 Internal Tandem Duplication | Stem Cell Exhaustion | Our data identified that old age, pre-HCT markers for MRD, and high post-HCT WT1, high dose of CD34+ stem cell (>=4.5 x 106/kg) infusion, and c-kit or FLT3-ITD mutations were associated with higher relapse rate and poor DFS. | 28089879 |
| Infectious Lung Disorder | Stem Cell Exhaustion | Suspected Pulmonary Infection with Trichoderma longibrachiatum after Allogeneic Stem Cell Transplantation. | 28090056 |
| Aplastic Anemia, Infectious Lung Disorder | Stem Cell Exhaustion | We herein report a case of isolated suspected invasive pulmonary infection with T. longibrachiatum in a 29-year-old man with severe aplastic anemia who underwent allogeneic stem cell transplantation. | 28090056 |
| Secondary malignant neoplasm of liver, Portal vein structure | Stem Cell Exhaustion | Portal Vein Embolization with Contralateral Application of Stem Cells Facilitates Increase of Future Liver Remnant Volume in Patients with Liver Metastases. | 28091729 |
| Secondary malignant neoplasm of liver | Stem Cell Exhaustion | This study aimed to evaluate the progress of future liver remnant volume (FLRV) in patients with liver metastases after portal vein embolization (PVE) with the application of hematopoietic stem cells (HSCs) and compare it with a patients control group after PVE only. | 28091729 |
| Hodgkin Disease, LIPC gene | Stem Cell Exhaustion | We investigated the use of haploidentical hematopoietic stem cell transplantation (haplo-HSCT) in the treatment of advanced Hodgkin lymphoma (HL). | 28092347 |
| Nephrotoxic | Stem Cell Exhaustion | Calcineurin inhibitor (CNI)-sparing T-cell depleted (TCD) hematopoietic stem cell transplants (HSCTs) are presumed to be less nephrotoxic than conventional HSCTs. | 28092350 |
| Hepatic Veno-Occlusive Disease, leukemia | Stem Cell Exhaustion | Risk of sinusoidal obstruction syndrome in allogeneic stem cell transplantation after prior gemtuzumab ozogamicin treatment: a retrospective study from the Acute Leukemia Working Party of the EBMT. | 28092357 |
| Hepatic Veno-Occlusive Disease, Spondylo-ocular syndrome | Stem Cell Exhaustion | Gemtuzumab ozogamicin (GO) may increase the risk of sinusoidal obstruction syndrome (SOS) when used prior to allogeneic stem cell transplantation (HSCT). | 28092357 |
| Specialty Type - cancer | Stem Cell Exhaustion | In addition, enforced expression of miR-215 suppressed the cancer stem cell signature through downregulation of intestinal stem cell markers including Lgr5. | 28092415 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Tumor stem cells with self-renewal and multipotent capacity play critical roles in the initiation and progression of cancer. | 28092415 |
| Ischemic stroke | Stem Cell Exhaustion | Changes in serum vascular endothelial growth factor and endostatin concentrations associated with circulating endothelial progenitor cells after acute ischemic stroke. | 28093678 |
| Chemical injury | Stem Cell Exhaustion | Circulating endothelial progenitor cells (EPCs) also play an important role as an endogenous repair mechanism for ischemic injury. | 28093678 |
| Extrapulmonary Small Cell Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | When siRNA was used to knockdown Numb in ESCC cell lines, there was a consistent increase in caspase-3 dependent apoptosis and inhibition of cellular proliferation, as well as downregulation of expression of the cancer stem cell markers Oct-4, SOX-2 and Nanog. | 28095111 |
| Infection | Stem Cell Exhaustion | After allogeneic hematopoietic stem cell transplantation (HSCT), recovery of humoral immunity is essential to protect from life-threatening infections. | 28095438 |
| Musculoskeletal Diseases | Stem Cell Exhaustion | Stem cell-based therapies are being considered for the treatment of musculoskeletal diseases, but the presence of these inflammatory cytokines will have similar deleterious action on therapeutic cells delivered to these environments. | 28095751 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | CD25 has been reported to be highly expressed in leukemia stem cells and correlated with adverse outcomes in young patients with acute myeloid leukemia (AML). | 28097942 |
| Dysautonomia, Familial | Stem Cell Exhaustion | Given the systemic nature of enzyme deficiency, we hypothesized that the stem cell compartment of GD and FD patients might be also affected. | 28098348 |
| Lysosomal Storage Diseases | Stem Cell Exhaustion | Impact of lysosomal storage disorders on biology of mesenchymal stem cells: Evidences from in vitro silencing of glucocerebrosidase (GBA) and alpha-galactosidase A (GLA) enzymes. | 28098348 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Allogeneic stem cell transplantation in adult patients with acute myeloid leukaemia and 17p abnormalities in first complete remission: a study from the Acute Leukemia Working Party (ALWP) of the European Society for Blood and Marrow Transplantation (EBMT). | 28100265 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Acute myeloid leukaemia (AML) with 17p abnormalities (abn(17p)) carries a very poor prognosis due to high refractoriness to conventional chemotherapy, and allogeneic stem cell transplantation (allo-SCT) appears as the only potential curative option. | 28100265 |
| Depression, CTCAE | Stem Cell Exhaustion | Impact of pre-transplant depression on outcomes of allogeneic and autologous hematopoietic stem cell transplantation. | 28102896 |
| Acute leukemia | Stem Cell Exhaustion | A comparison between allogeneic stem cell transplantation from unmanipulated haploidentical and unrelated donors in acute leukemia. | 28103944 |
| Acute leukemia | Stem Cell Exhaustion | In the absence of a HLA-matched related or matched unrelated donor, allogeneic stem cell transplantation (allo-SCT) from mismatched unrelated donors or haploidentical donors are potential alternatives for patients with acute leukemia with an indication to allo-SCT. | 28103944 |
| Multiple Myeloma | Stem Cell Exhaustion | Efficacy and safety of high-dose chemotherapy with autologous stem cell transplantation in senior versus younger adults with newly diagnosed multiple myeloma. | 28105753 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | We retrospectively studied 340 fit patients with multiple myeloma (MM) who underwent autologous stem cell transplantation (ASCT). | 28105753 |
| Esophageal Small Cell Carcinoma | Stem Cell Exhaustion | In addition, SOX2 overexpression observed in esophageal and lung small-cell carcinoma as well as in the embryonic esophagus indicated that esophageal small-cell carcinoma may arise from embryonic-like stem cells in the esophageal epithelium. | 28106103 |
| Esophageal Small Cell Carcinoma | Stem Cell Exhaustion | The two distinct differentiation patterns (neuroendocrine and glandular) of esophageal small-cell carcinoma further support the fact that SOX2 has a pivotal role in the differentiation of pluripotent stem cells into esophageal small-cell carcinoma cells. | 28106103 |
| Malignant Neoplasms | Stem Cell Exhaustion | Aldehyde dehydrogenase 1 (ALDH1) has been proposed as biomarker of stem cells for certain human cancers. | 28106104 |
| Multiple Myeloma | Stem Cell Exhaustion | Chorioretinal folds in a patient with multiple myeloma treated with stem cell transplant. | 28106236 |
| Multiple Myeloma | Stem Cell Exhaustion | Subsequently, she was treated with stem cell transplant for myeloma, which resulted in remission of her disease. | 28106236 |
| Cerebral Palsy | Stem Cell Exhaustion | Neuroregenerative potential of intravenous G-CSF and autologous peripheral blood stem cells in children with cerebral palsy: a randomized, double-blind, cross-over study. | 28109298 |
| Multiple Myeloma | Stem Cell Exhaustion | Bortezomib and thalidomide maintenance after stem cell transplantation for multiple myeloma: a PETHEMA/GEM trial. | 28111466 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | The phase III trial GEM05MENOS65 randomized 390 patients 65 years old or younger with newly diagnosed symptomatic multiple myeloma (MM) to receive induction with thalidomide/dexamethasone, bortezomib/thalidomide/dexamethasone and Vincristine, BCNU, melphalan, cyclophosphamide, prednisone/vincristine, BCNU, doxorubicin, dexamethasone bortezomib (VBMCP/VBAD/B) followed by autologous stem cell transplantation (ASCT) with MEL-200. | 28111466 |
| Clear cell adenocarcinoma of ovary, Specialty Type - cancer | Stem Cell Exhaustion | Low uptake of fluorodeoxyglucose in positron emission tomography/computed tomography in ovarian clear cell carcinoma may reflect glutaminolysis of its cancer stem cell-like properties. | 28112360 |
| Specialty Type - cancer | Stem Cell Exhaustion | We obtained cancer stem cell (CSC)-like properties from CCC cell lines, and compared the expression levels of transporters between non-CSCs and CSCs. | 28112360 |
| Specialty Type - cancer | Stem Cell Exhaustion | MicroRNA (miR)-145 has been reported to induce cancer stem cell (CSC) differentiation through down-regulation of the stem cell transcription factors (TFs) that maintain CSC pluripotency. | 28112371 |
| Malignant tumor of cervix | Stem Cell Exhaustion | MicroRNA-145 inhibits tumorigenesis and invasion of cervical cancer stem cells. | 28112371 |
| Malignant tumor of cervix, Specialty Type - cancer | Stem Cell Exhaustion | High expression of miR-145 indicates a good prognosis in cancer patients, but its role in cervical cancer stem cells (CCSCs) is not known. | 28112371 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | For young patients with high-risk CLL, BTK-/PI3K-inhibitors or allogeneic stem cell transplantation (alloHCT) are considered. | 28112746 |
| Specialty Type - cancer, Aggressive behavior, Neoplasms | Stem Cell Exhaustion | Cancer stem cells (CSCs), a subset of tumor cells, contribute to an aggressive biological behavior, which is also affected by the tumor stroma. | 28114366 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Mesenchymal stem cells (MSCs) are promising candidates as a cell-based therapy for osteoarthritis (OA), although current results are modest. | 28114800 |
| Cyclic neutropenia | Stem Cell Exhaustion | Episodes of BSI due to ESBL-GNB occurring in haematological patients and haematopoietic stem cell transplant recipients with neutropaenia from 1 January 2006 to 31 March 2015 will be analysed. | 28115333 |
| Candidemia | Stem Cell Exhaustion | Clinical and Microbiological Characteristics of Breakthrough Candidemia in Allogeneic Hematopoietic Stem Cell Transplant Recipients in a Japanese Hospital. | 28115352 |
| Candidemia | Stem Cell Exhaustion | Few data on breakthrough candidemia (BC), defined as candidemia that develops on administration of antifungal agents (AFAs), in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients are available. | 28115352 |
| Burn, CTCAE | Stem Cell Exhaustion | This work aims to standardize the isolation of amniotic stem cells and the selection of the optimal time of transplantation and cell application methods in burn patients according to the guidelines of the Good Manufacturing Practice. | 28117628 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Impact of in vivo T cell depletion in HLA-identical allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission conditioned with a fludarabine iv-busulfan myeloablative regimen: a report from the EBMT Acute Leukemia Working Party. | 28118857 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We retrospectively analyzed 566 patients who underwent a first HLA-identical allogeneic stem cell transplantation with this conditioning regimen for acute myeloid leukemia in first complete remission between 2006 and 2013 and compared the outcomes of 145 (25.6%) patients who received ATG (ATG group) to 421 (74.4%) who did not (no-ATG group). | 28118857 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | These results suggest that the use of ATG with fludarabine and 4 days intravenous busulfan followed by HLA-identical sibling donor allogeneic stem cell transplantation for acute myeloid leukemia improves overall transplant outcomes due to reduced incidence of chronic GVHD without increased relapse risk. | 28118857 |
| Acute leukemia | Stem Cell Exhaustion | Impact of recommended weight-based dosing of granulocyte-colony stimulating factors in acute leukemia and stem cell transplant patients. | 28120115 |
| Acute leukemia | Stem Cell Exhaustion | A retrospective chart review of patients with acute leukemia or stem cell transplant recipients who received G-CSF from May 2009 to September 2015 was conducted. | 28120115 |
| Hematopoietic | Stem Cell Exhaustion | Mice homozygous for a null Brca1 mutation in the embryonic hematopoietic system (Vav1-iCre;Brca1F22-24/F22-24) developed hematopoietic defects in early adulthood that included reduced hematopoietic stem cells (HSCs). | 28122244 |
| Hematopoietic stem cells, Hematopoietic | Stem Cell Exhaustion | Although mice homozygous for a huBRCA1 knockin allele (Brca1BRCA1/BRCA1) were normal, mice with a mutant huBRCA1/5382insC allele and a null allele (Mx1-Cre;Brca1F22-24/5382insC) had severe hematopoietic defects marked by a complete loss of hematopoietic stem and progenitor cells. | 28122244 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | We find that GBM induced in neural stem-cell-like glial fibrillary acidic protein (GFAP)-expressing cells in the subventricular zone of adult mice shows accelerated tumor development and produces more malignant GCs (mGC1GFAP) that are less resistant to cancer drugs, compared with those originating from more differentiated nestin- (mGC2NES) or 2,'3'-cyclic nucleotide 3'-phosphodiesterase (mGC3CNP)-expressing cells. | 28122246 |
| Carcinoma | Stem Cell Exhaustion | Integrative genomic analysis of HCC-CCAs revealed that cholangiolocellular carcinoma (CLC) represents a distinct biliary-derived entity compared with the stem-cell and classical types. | 28126467 |
| Neoplasms | Stem Cell Exhaustion | Stem-cell tumors were characterized by spalt-like transcription factor 4 (SALL4) positivity (6/8 vs. 0/10, p<0.001), enrichment of progenitor-like signatures, activation of specific oncogenic pathways (i.e., MYC and insulin-like growth factor [IGF]), and signatures related to poor clinical outcome. | 28126467 |
| Neoplasms, Hollings Cancer Center | Stem Cell Exhaustion | Mixed HCC-CCA represents a heterogeneous group of tumors, with the stem-cell type characterized by features of poor prognosis, and the classical type with common lineage for HCC and iCCA components. | 28126467 |
| Intrahepatic Route of Drug Administration, Neoplasms, Hollings Cancer Center | Stem Cell Exhaustion | However, within mixed HCC-CCA, stem-cell type tumors shared an aggressive nature and poor outcome, whereas the classic type showed a common cell lineage for both the HCC and the intrahepatic CCA component. | 28126467 |
| Multiple Myeloma | Stem Cell Exhaustion | Recovery of polyclonal immunoglobulins one year after autologous stem cell transplantation as a long-term predictor marker of progression and survival in multiple myeloma. | 28126960 |
| Atrial Fibrillation by ECG Finding | Stem Cell Exhaustion | Permanent atrial fibrillation impairs the function of circulating endothelial progenitor cells. | 28128678 |
| Atrial Fibrillation by ECG Finding | Stem Cell Exhaustion | to determine whether functions of endothelial progenitor cells (EPCs) were impaired in patients with permanent atrial fibrillation (AF). | 28128678 |
| Doctor of Chiropractic, Dilated Cardiomyopathy Pathway | Stem Cell Exhaustion | Here, we show that treatment of human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) and neonatal rat ventricular myocytes (NRVMs) with serum from pediatric dilated cardiomyopathy (DCM) patients induces pathological changes in gene expression, which occur independently of the RAAS and adrenergic systems, suggesting that serum circulating factors play an important role in cardiac remodeling. | 28130338 |
| Graft-vs-Host Disease, Myeloid neoplasm | Stem Cell Exhaustion | We conducted a pilot study on the feasibility of CD56-enriched donor cell infusion after post-transplantation cyclophosphamide (PTCy) for 10 patients with advanced myeloid malignancies undergoing haploidentical peripheral blood stem cell transplantation with cyclosporine alone as graft-versus-host disease (GVHD) prophylaxis and compared the outcome and immune reconstitution with a control group of 20 patients undergoing the same without CD56-enriched donor cell infusion. | 28131632 |
| methyldopa | Stem Cell Exhaustion | We report the derivation of human-induced pluripotent stem cells (hiPSCs) from patients with diagnosed AMD, including two donors with the rare ARMS2/HTRA1 homozygous genotype. | 28132833 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Prognostic impact of the CD34+/CD38- cell burden in patients with acute myeloid leukemia receiving allogeneic stem cell transplantation. | 28133783 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Here we evaluated clinical and biological associations and the prognostic impact of a high diagnostic CD34+/CD38- cell burden in 169 AML patients receiving an allogeneic stem cell transplantation in complete remission. | 28133783 |
| Toxic nephropathy | Stem Cell Exhaustion | Allogeneic hemopoietic stem cell transplantation (allo-HSCT) poses a significant challenge to renal function due to multiple drug- and complication-related renal toxicity. | 28135776 |
| Dementia, Vascular | Stem Cell Exhaustion | Umbilical cord-derived mesenchymal stem cell transplantation for treating elderly vascular dementia. | 28138805 |
| VAD I protocol, Dementia, Vascular | Stem Cell Exhaustion | This study aimed to determine the efficacy and safety of human umbilical cord-derived mesenchymal stem cell (HUC-MSC) transplantation for treating elderly vascular dementia (VaD). | 28138805 |
| Cerebrovascular accident | Stem Cell Exhaustion | Attitudes to Stem Cell Therapy Among Ischemic Stroke Survivors in the Lund Stroke Recovery Study. | 28142330 |
| Multiple Myeloma | Stem Cell Exhaustion | Polymorphism in ANRIL is associated with relapse in patients with multiple myeloma after autologous stem cell transplant. | 28150872 |
| Aplastic Anemia, Dry cough | Stem Cell Exhaustion | A 23-year-old man who had previously undergone allogeneic hematopoietic stem cell transplantation (allo-HSCT) for severe aplastic anemia was diagnosed with invasive laryngeal-tracheobronchial-pulmonary aspergillosis after presenting with a persistent dry cough at six months post-transplantation based on the findings of laryngoscopy and fiberoptic bronchoscopy. | 28154281 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | BACKGROUND Acute graft-versus-host disease (aGVHD) remains the most common and challenging complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 28154370 |
| Icterus | Stem Cell Exhaustion | In this study, we transplanted human neural progenitor cells differentiated toward propriospinal interneurons into the striatum of 20-day-old spontaneously jaundiced (jj) Gunn rats and nonjaundiced (Nj) littermates. | 28155818 |
| Malignant Neoplasms | Stem Cell Exhaustion | Zinc finger protein X-linked (ZFX) is frequently upregulated in multiple human malignancies and also plays a critical role in the maintenance of self-renewal in embryonic stem cells. | 28156061 |
| Malignant neoplasm of liver | Stem Cell Exhaustion | However, the role of ZFX in liver cancer stem cells (CSCs) remains obscure. | 28156061 |
| Cessation of life | Stem Cell Exhaustion | Treatment, when reported (n = 136), included explantation [n = 125 (91.9 percent)], chemotherapy [n = 42 (30.8 percent)], radiation therapy [n = 25 (18.4 percent)], and/or stem cell transplant [n = 9 (6.6 percent)], and five deaths were reported. | 28157770 |
| Prediabetes syndrome, Neurologic Deficits | Stem Cell Exhaustion | Therefore, we tested the hypothesis that metformin, an AMPK activator, protects against diabetic AGE induced neuronal impairment in human neural stem cells (hNSCs). | 28159472 |
| Hemorrhagic cystitis | Stem Cell Exhaustion | Nationwide survey of BK polyomavirus associated hemorrhagic cystitis in adult allogeneic stem cell transplantation among haematologists and urologists. | 28160087 |
| Hemorrhagic cystitis | Stem Cell Exhaustion | There are no epidemiological data on BK virus associated hemorrhagic cystitis (BKHC) in adult allogeneic stem cell transplantation in Germany available and associations with clinical conditions like GvHD are controversially discussed. | 28160087 |
| Toxic effect, Gastrointestinal mucositis, Multiple Myeloma | Stem Cell Exhaustion | High-dose melphalan followed by autologous stem cell transplantation remains the standard of care for eligible patients with multiple myeloma, but disease response and toxicity, including severe mucositis, varies among patients. | 28160288 |
| diabetic | Stem Cell Exhaustion | p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo. | 28163043 |
| Diabetes Mellitus | Stem Cell Exhaustion | Therefore our results provide a support for bFGF as a potential therapeutic agent for improving stem cell-based approaches for the treatment of diabetes mellitus and its complications. | 28168007 |
| Lymphoma, Non-Hodgkin | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation for non-Hodgkin's lymphomas: a retrospective analysis of 77 cases. | 28168350 |
| Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (allo-SCT) is a therapeutic option for relapsed, advanced, and otherwise incurable non-Hodgkin's lymphomas (NHL) suggested by the existence of a graft-versus-lymphoma effect. | 28168350 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | 4 PATIENT: A 59-year-old man underwent stem cell transplantation for acute myeloid leukemia. | 28168387 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer cells use alternate energetic pathways; however, cancer stem cell (CSC) metabolic energetic pathways are unknown. | 28168879 |
| Aplastic Anemia | Stem Cell Exhaustion | Allogeneic haematopoietic stem cell transplantation is curative for severe aplastic anaemia (SAA) unresponsive to immunosuppressive therapy. | 28169418 |
| Graft-vs-Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | To reduce chronic graft-versus-host disease (GVHD), which occurs more frequently after peripheral blood stem cell (PBSC) transplantation compared to bone-marrow transplantation (BMT), and to prevent graft rejection, we developed a novel partial T-cell depleted transplant that infuses high numbers of granulocyte colony-stimulating factor-mobilized CD34+ selected PBSCs combined with a BMT-equivalent dose of non-mobilized donor T-cells. | 28169418 |
| Aplastic Anemia | Stem Cell Exhaustion | Allogeneic transplantation using CD34+ selected peripheral blood progenitor cells combined with non-mobilized donor T cells for refractory severe aplastic anaemia. | 28169418 |
| Lupus Erythematosus | Stem Cell Exhaustion | JAK-STAT signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients. | 28177455 |
| Lupus Erythematosus, Encephalitis, St. Louis | Stem Cell Exhaustion | Previous studies have revealed that bone marrow-mesenchymal stem cells (BM-MSCs) from systemic lupus erythematosus (SLE) patients exhibited early signs of senescence, which may participate in the development of SLE. | 28177455 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Prognostic Mutations in Myelodysplastic Syndrome after Stem-Cell Transplantation. | 28177873 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | Genetic profiling revealed that molecular subgroups of patients undergoing allogeneic hematopoietic stem-cell transplantation for MDS may inform prognostic stratification and the selection of conditioning regimen. | 28177873 |
| Keratopathy | Stem Cell Exhaustion | On her last follow-up 14 years after PK in 2016, her vision in the left eye was 20/40 with lipid keratopathy and her right eye showed no signs of focal limbal stem cell deficiency. | 28179383 |
| Specialty Type - cancer, Neoplasms, Central neuroblastoma | Stem Cell Exhaustion | These findings suggest the possibility of developing novel therapeutic strategies against PNETs by targeting DCLK1.Implications: Evidence here reveals that human PNETs diffusely and robustly express the cancer stem cell marker DCLK1, which drives SLUG-mediated EMT, and suggests that NETs share biological features for druggable targets with other tumors, including neuroblastoma that also highly expresses DCLK1. | 28179411 |
| Neuroblastoma, Pancreatic carcinoma | Stem Cell Exhaustion | Doublecortin-like kinase 1 (DCLK1), a marker for intestinal and pancreatic cancer stem cells, is highly expressed in neuroblastomas. | 28179411 |
| Fatigue | Stem Cell Exhaustion | On univariate analysis fatigue, QOL, physician-reported performance status, autologous stem cell transplant (ASCT), and Mayo stage were prognostic for survival. | 28181278 |
| Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Patient age and number of apheresis days may predict development of secondary myelodysplastic syndrome and acute myelogenous leukemia after high-dose chemotherapy and autologous stem cell transplantation for lymphoma. | 28185276 |
| Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | The goal of our study was to find predictors for the development of secondary myelodysplastic syndrome or acute myelogenous leukemia (s-MDS/AML) in patients with relapsed or refractory lymphoma who received high-dose chemotherapy and autologous stem cell transplantation (ASCT). | 28185276 |
| Lymphoma | Stem Cell Exhaustion | We conducted a retrospective review of 295 patients with relapsed or refractory lymphoma who had undergone their first stem cell collection and ASCT. | 28185276 |
| Spinal Cord Injuries | Stem Cell Exhaustion | Clinical Study of NeuroRegen Scaffold Combined With Human Mesenchymal Stem Cells for the Repair of Chronic Complete Spinal Cord Injury. | 28185615 |
| Stanford Cancer Institute | Stem Cell Exhaustion | In this study, eight patients with chronic complete SCI were enrolled to examine the safety and efficacy of implanting NeuroRegen scaffold with human umbilical cord mesenchymal stem cells (hUCB-MSCs). | 28185615 |
| Malignant neoplasm of liver | Stem Cell Exhaustion | In this study, we investigated the functional role of HBx-DC1 in regulating liver cancer stem cell (CSC) properties. | 28186991 |
| Injury of liver | Stem Cell Exhaustion | Using a murine model of liver injury, we previously identified the importance of canonical Hh signaling within the Pc+ liver progenitor cell (LPC) population and noted that SMO-independent, GLI-mediated signals were important in multiple Pc-ve GLI2+ intrahepatic populations. | 28187190 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | In addition, the regenerative potential of purified stem cells was assessed 3 weeks after transplantation in immunodeficient mice which had been subjected to experimental myocardial infarction. | 28187777 |
| Adult Glioblastoma | Stem Cell Exhaustion | High-dose Neural Stem Cell Radiation May Not Improve Survival in Glioblastoma. | 28188088 |
| Adult Glioblastoma, Chemoradiotherapy | Stem Cell Exhaustion | To evaluate the effect of radiotherapy dose-volume parameters of neural stem cell (NSC) compartment on progression-free survival (PFS) and overall survival after post-resection chemoradiation in newly diagnosed glioblastoma. | 28188088 |
| Cessation of life, Ann Arbor Stage I Nasal Type NK/T-Cell Lymphoma | Stem Cell Exhaustion | Seven male patients with NK/T-cell lymphoma (median age, 49 years; range, 31-68 years) for whom a median of 2 (range, 1-5) regimens (including l-asparaginase regimens and allogeneic hematopoietic stem-cell transplantation [HSCT] in 2 cases) failed were treated with the anti-programmed death 1 (PD1) antibody pembrolizumab. | 28188133 |
| Specialty Type - cancer | Stem Cell Exhaustion | Stem Cell Reviews and Reports: Cancer Stem Cells and Aging Section. | 28188496 |
| Malignant Neoplasms | Stem Cell Exhaustion | Sex-determining region Y-box 2 (SOX2) is an essential factor involved in the self-renewal and pluripotency of embryonic stem cells and has functions in cell survival and progression in many types of cancers. | 28188685 |
| leukemia | Stem Cell Exhaustion | Decitabine before Low-Dose Cytarabine-Based Chemotherapy Combined with Human Leukocyte Antigen-Mismatched Stem Cell Microtransplantation Improved Outcomes in Elderly Patients with Newly Diagnosed Acute Myeloid Leukemia. | 28189902 |
| Graft-vs-Host Disease, Toxic effect, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We conducted a prospective study of 23 elderly patients (median age, 68 years; range, 60 to 87 years) with newly diagnosed AML to evaluate the efficacy and toxicity of decitabine plus granulocyte colony-stimulating factor priming, low-dose aclarubicin, and cytarabine (DCAG) chemotherapy combined with HLA-mismatched stem cell microtransplantation (SC-MST) without graft-versus-host disease (GVHD) prophylaxis. | 28189902 |
| Neoplasms, Carcinogenesis | Stem Cell Exhaustion | Expression of the stem cell marker CD133 is related to tumor development in colorectal carcinogenesis. | 28190751 |
| Colorectal Carcinoma | Stem Cell Exhaustion | CD133 is currently considered the most robust surface marker for colorectal cancer stem cells. | 28190751 |
| Doctor of Chiropractic, Dilated Cardiomyopathy Pathway | Stem Cell Exhaustion | Stem cell therapy has shown therapeutic benefit in dilated cardiomyopathy (DCM), but doubt remains about the most appropriate stem cell subpopulation. | 28190794 |
| Doctor of Chiropractic | Stem Cell Exhaustion | There were no differences in MACE among the 3 groups (P = 0.817).Intracoronary bone marrow stem cell transplantation in DCM is safe and effective, while BMSC and BMMC infusion possess comparable effectiveness. | 28190794 |
| Dilated Cardiomyopathy Pathway | Stem Cell Exhaustion | A Randomized Comparative Study on the Efficacy of Intracoronary Infusion of Autologous Bone Marrow Mononuclear Cells and Mesenchymal Stem Cells in Patients With Dilated Cardiomyopathy. | 28190794 |
| Doctor of Chiropractic | Stem Cell Exhaustion | The current study compared the efficacy of intracoronary administration of bone marrow mononuclear cells (BMMC) or mesenchymal stem cells (BMSC) in patients with DCM.Fifty-three patients with DCM and reduced (< 40%) left ventricular ejection fraction (LVEF), were randomized to intracoronary infusion of BMMC (BMMC group, n = 16) or BMSC (BMSC group, n = 17) or equal volume normal saline (CTRL group, n = 20). | 28190794 |
| Benign prostatic hypertrophy | Stem Cell Exhaustion | Aberrant Transforming Growth Factor-b Activation Recruits Mesenchymal Stem Cells During Prostatic Hyperplasia. | 28191756 |
| Benign prostatic hypertrophy | Stem Cell Exhaustion | In this study, we show that aberrant activation of transforming growth factor-b (TGF-b) mobilizes mesenchymal/stromal stem cells (MSCs) in circulating blood, which are recruited for the prostatic stromal hyperplasia. | 28191756 |
| Osteosarcoma | Stem Cell Exhaustion | Generation of Osteosarcomas from a Combination of Rb Silencing and c-Myc Overexpression in Human Mesenchymal Stem Cells. | 28191765 |
| Play | Stem Cell Exhaustion | Suppression of Transforming Growth Factor-b Signaling Delays Cellular Senescence and Preserves the Function of Endothelial Cells Derived from Human Pluripotent Stem Cells. | 28191769 |
| Vascular Diseases | Stem Cell Exhaustion | Transplantation of vascular cells derived from human pluripotent stem cells (hPSCs) offers an attractive noninvasive method for repairing the ischemic tissues and for preventing the progression of vascular diseases. | 28191769 |
| Neurotoxicity Syndromes | Stem Cell Exhaustion | The neurons derived for the human induced pluripotent stem cells (hiPSCs) provide a relevant and powerful tool for the research in pharmaceutical and environmental neurotoxicity. | 28193519 |
| Nerve Degeneration | Stem Cell Exhaustion | In this study, we for the first time used human induced pluripotent stem cells (hiPSCs)-derived neurons (iCell neurons) to investigate the mechanisms of TD-induced neurodegeneration. | 28193519 |
| Specialty Type - cancer | Stem Cell Exhaustion | Recently, it was suggested that tissue variation in cancer risk originates from differences in the number of stem-cell divisions underlying each tissue, leading to different mutation loads. | 28193856 |
| Secondary Neoplasm, Esophageal Neoplasms | Stem Cell Exhaustion | Stem cell autocrine CXCL12/CXCR4 stimulates invasion and metastasis of esophageal cancer. | 28193907 |
| Neoplasms, Secondary Neoplasm, Esophageal Neoplasms | Stem Cell Exhaustion | Esophageal cancer stem cells are considered the source for recurrence and metastasis of the tumors. | 28193907 |
| Esophageal Neoplasms | Stem Cell Exhaustion | This study found that esophageal cancer stem cells not only autocrine a great amount of CXCL12, but also high expression of its corresponding receptor CXCR4. | 28193907 |
| Esophageal Neoplasms | Stem Cell Exhaustion | Most importantly, the ability of esophageal cancer stem cells to spread and metastasize could be inhibited by blockage of CXCR4 with inhibitors or shRNA approaches both in vivo and in vitro studies. | 28193907 |
| Secondary Neoplasm, Esophageal Neoplasms | Stem Cell Exhaustion | The important role of CXCL12 in the invasion and metastasis of esophageal cancer stem cells was also confirmed by loss-of-function and gain-of-function strategies. | 28193907 |
| Secondary Neoplasm, Esophageal Neoplasms | Stem Cell Exhaustion | Mechanistically, we demonstrated that CXCL12/CXCR4 activated the ERK1/2 pathway and thereby ultimately maintained the characteristics of high-level invasion and metastasis of esophageal cancer stem cells. | 28193907 |
| Esophageal Neoplasms | Stem Cell Exhaustion | Taken together, our findings suggested that autocrine CXCL12/CXCR4 was one of the major mechanisms underlying the metastatic property of esophageal cancer stem cells through ERK1/2 signaling pathway, and might serve as a therapeutic target for esophageal cancer patients. | 28193907 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Inhibition of serotonin receptor type 1 in acute myeloid leukemia impairs leukemia stem cell functionality: a promising novel therapeutic target. | 28193998 |
| Neoplasms, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Acute myeloid leukemia (AML) is a clinically and molecularly heterogeneous neoplasia with poor outcome, organized as a hierarchy initiated and maintained by a sub-population with differentiation and self-renewal capacities called leukemia stem cells (LSCs). | 28193998 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Hematopoietic stem cell remobilization with vinorelbine and filgrastim in AML. | 28194031 |
| Ataxia, Spinocerebellar | Stem Cell Exhaustion | Treatment of Spinocerebellar Ataxia With Mesenchymal Stem Cells: A Phase I/IIa Clinical Study. | 28195034 |
| Neurodegenerative Disorders | Stem Cell Exhaustion | Mesenchymal stem cells (MSCs) have shown promise in treating neurodegenerative diseases. | 28195034 |
| Specialty Type - cancer | Stem Cell Exhaustion | All three models demonstrate substantial variation in cancer risks, by at least 20 orders of magnitude, depending on the assumed number of critical mutations required for cancer, and the stem-cell and transition-cell mutation rates. | 28196079 |
| Malignant Neoplasms | Stem Cell Exhaustion | However, for cancers with 2 or 3 critical mutations, a substantial proportion of cancers, in some cases 100%, have at least one mutation derived from a mutated stem cell. | 28196079 |
| Specialty Type - cancer | Stem Cell Exhaustion | The probability of a cancer being mutagen-induced correlates across cancer sites with the estimated cumulative number of stem cell divisions in the associated tissue (p<0.05), although in some cases there is sensitivity of findings to removal of high-leverage outliers and in some cases only modest variation in probability, but these issues do not affect the validity of the findings. | 28196079 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cairns suggested that renewing tissues may reduce cancer risk by partitioning the dividing cell populations into lineages comprising infrequently-dividing long-lived stem cells and frequently-dividing short-lived daughter transit cells. | 28196079 |
| Malignant Neoplasms | Stem Cell Exhaustion | Very few cancers, generally <0.5%, arise from mutations occurring solely in stem cells rather than in a combination of stem and transit cells. | 28196079 |
| Malignant Neoplasms | Stem Cell Exhaustion | Little difference is made to relative risks if competing processes of proliferation and differentiation in the partially transformed stem and transit cell population are allowed for, nor is any difference made if one assumes that transit cells require an extra mutation to confer malignancy from the number required by stem cells. | 28196079 |
| Acute lymphocytic leukemia, BCR gene | Stem Cell Exhaustion | Allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia who had central nervous system involvement: a study from the Adult ALL Working Group of the Japan Society for Hematopoietic Cell Transplantation. | 28197965 |
| Acute lymphocytic leukemia, BCR gene | Stem Cell Exhaustion | The prognosis for adult acute lymphoblastic leukemia (ALL) patients with central nervous system (CNS) involvement (CNS+) who received allogeneic hematopoietic stem cell transplantation (allo-SCT) remains unclear. | 28197965 |
| Lymphoma | Stem Cell Exhaustion | Purpose The benefit of high-dose chemotherapy with autologous stem-cell transplantation (ASCT) as first-line treatment in patients with diffuse large B-cell lymphomas is still a matter of debate. | 28199143 |
| Hematological Disease | Stem Cell Exhaustion | In this study, we analyzed the safety of PICC placement in patients with hematologic diseases where PICCs had been placed to perform blood collection, blood transfusion, drug administration, and hematopoietic stem cell transplantation. | 28202859 |
| Cerebrovascular accident | Stem Cell Exhaustion | Spontaneous Recovery of Upper Extremity Motor Impairment After Ischemic Stroke: Implications for Stem Cell-Based Therapeutic Approaches. | 28205065 |
| Cerebrovascular accident | Stem Cell Exhaustion | Preclinical studies suggest that stem cell therapy (SCT) may improve sensorimotor recovery after stroke. | 28205065 |
| Lymphoma | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplantation in lymphoma patients is associated with a decrease in the double strand break repair capacity of peripheral blood lymphocytes. | 28207808 |
| Lymphoma, MLF1 gene | Stem Cell Exhaustion | Patients who undergo autologous hematopoietic stem cell transplantation (aHCT) for treatment of a relapsed or refractory lymphoma are at risk of developing therapy related- myelodysplasia/acute myeloid leukemia (t-MDS/AML). | 28207808 |
| Graft-vs-Host Disease, Engraftment syndrome | Stem Cell Exhaustion | Multivariate analysis showed that CBT, mycophenolate mofetil (MMF) for graft-versus-host disease prophylaxis, history of allogeneic hematopoietic stem cell transplantation (allo-HSCT), and engraftment syndrome (ES) were significantly associated with incidence of HHV-6 encephalitis/myelitis (P=.025, P=.017, P=.017, and P=.014, respectively). | 28207973 |
| Multiple Myeloma | Stem Cell Exhaustion | Impact of induction treatment before autologous stem cell transplantation on long-term outcome in patients with newly diagnosed multiple myeloma. | 28208219 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Clinical trials for patients with multiple myeloma (MM) using novel agent (NA)-based regimens before autologous stem cell transplantation (SCT) have shown improvement in response rates and progression-free survival (PFS); however they have failed to identify a significant overall survival (OS) benefit. | 28208219 |
| Encephalitis, Neurogenic Inflammation | Stem Cell Exhaustion | Mesenchymal stem cells alleviate Japanese encephalitis virus-induced neuroinflammation and mortality. | 28209182 |
| Inflammation | Stem Cell Exhaustion | Mesenchymal stem cells (MSCs) have been demonstrated to have a therapeutic effect on many central nervous system (CNS) diseases by regulating inflammation and other mechanisms. | 28209182 |
| LMNA wt Allele | Stem Cell Exhaustion | Interestingly, SMCs derived from human induced pluripotent stem cells of HGPS donors (HGPS iPS-SMCs), but not from healthy donors, show an exacerbated inflammatory response to strain. | 28211642 |
| Malignant tumor of colon, Specialty Type - cancer | Stem Cell Exhaustion | Expression of the cancer stem cell markers ABCG2 and OCT-4 in right-sided colon cancer predicts recurrence and poor outcomes. | 28212529 |
| Specialty Type - cancer, Secondary Neoplasm, Refractory Cytopenia of Childhood | Stem Cell Exhaustion | Like cancer stem cells (CSCs), RCC cells cannot be fully eradicated and are often involved in relapse or metastasis. | 28212529 |
| Specialty Type - cancer, Adenocarcinoma Of Esophagus | Stem Cell Exhaustion | Expression profiles of cancer stem cell markers: CD133, CD44, Musashi-1 and EpCAM in the cardiac mucosa-Barrett's esophagus-early esophageal adenocarcinoma-advanced esophageal adenocarcinoma sequence. | 28216140 |
| Specialty Type - cancer | Stem Cell Exhaustion | A new hypothesis suggests that cancer is a disease of stem cells, however, their expression and pathways in BE - EAC sequence are not fully elucidated yet. | 28216140 |
| Specialty Type - cancer | Stem Cell Exhaustion | We used a panel of putative cancer stem cells markers to identify stem cells in consecutive steps of BE-related cancer progression. | 28216140 |
| Liver Cirrhosis, Autoimmune Diseases | Stem Cell Exhaustion | Effects of allogeneic mesenchymal stem cell transplantation in the treatment of liver cirrhosis caused by autoimmune diseases. | 28217916 |
| End Stage Liver Disease | Stem Cell Exhaustion | There has been great interest in recent years to take advantage of mesenchymal stem cells (MSCs) to treat end-stage liver disease. | 28217916 |
| Febrile Neutropenia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | This prospective study included 87 adult hematological patients with febrile neutropenia after an intensive chemotherapy for acute myeloid leukemia (AML) or after an autologous stem cell transplantation (ASCT). | 28218011 |
| leukemia | Stem Cell Exhaustion | Leukemia microvesicles affect healthy hematopoietic stem cells. | 28218044 |
| leukemia | Stem Cell Exhaustion | In this study, we investigate the effect of leukemia microvesicles on healthy umbilical cord blood hematopoietic stem cells to find evidence of cell information transferring. | 28218044 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Leukemia microvesicles were isolated from acute myeloid leukemia patients and were co-incubated with healthy hematopoietic stem cells. | 28218044 |
| leukemia | Stem Cell Exhaustion | Data showed a higher number of hematopoietic stem cells after being treated with leukemia microvesicles compared with control (treated with no microvesicles) and normal (treated with normal microvesicles) groups. | 28218044 |
| leukemia | Stem Cell Exhaustion | Our results suggest that leukemia microvesicles are able to induce some effects on healthy hematopoietic stem cells such as promoting cell survival and some microRNAs deregulation, while stemness is maintained. | 28218044 |
| Keratoconjunctivitis Sicca | Stem Cell Exhaustion | Chronic GvHD-related keratoconjunctivitis sicca (cGvHD-related KCS) can significantly alter the quality of life of patients after allogeneic hematopoietic stem cell transplantation. | 28218751 |
| Pneumonia | Stem Cell Exhaustion | CMV viral load in bronchoalveolar lavage for diagnosis of pneumonia in allogeneic hematopoietic stem cell transplantation. | 28218754 |
| Refractory Disease | Stem Cell Exhaustion | Sixty-seven patients received BV after autologous stem cell transplantation failure, whereas 28 patients were treated with BV without a prior autologous stem cell transplantation, due to advanced age/comorbidities or chemorefractory disease. | 28219112 |
| Pulmonary Complication, LYST gene, Chediak-Higashi Syndrome, Lymphohistiocytosis, Hemophagocytic | Stem Cell Exhaustion | An 8-year-old girl with Chediak-Higashi syndrome (CHS) had pulmonary complications after hematopoietic stem cell transplantation (HSCT) for hemophagocytic lymphohistiocytosis (HLH) and eventually underwent single living-donor lobar lung transplantation (LDLLT). | 28219570 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | Patients with relapsed diffuse large B-cell lymphoma (DLBCL) not eligible for autologous stem cell transplantation (ASCT) or having relapse after ASCT have a low likelihood of cure. | 28219694 |
| Bone necrosis | Stem Cell Exhaustion | Treatment of stage II medication-related osteonecrosis of the jaw with necrosectomy and autologous bone marrow mesenchymal stem cells. | 28220264 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | For refractory or relapsed acute myeloid leukemia patients, allogeneic hematopoietic stem cell transplantation is the only curative treatment option, but the disease must be in remission before this can be attempted. | 28220349 |
| Rhodococcus | Stem Cell Exhaustion | Rhodococcus Infection in Solid Organ and Hematopoietic Stem Cell Transplant Recipients1. | 28221102 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Patients and Methods Patients age 18 to 59 years old with intermediate- or unfavorable-risk AML in first remission and no identified donor for allogeneic stem-cell transplantation (SCT) were eligible. | 28221862 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | Autologous stem cell transplantation as frontline strategy for peripheral T-cell lymphoma: A single-centre experience. | 28222648 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | Objective To determine the efficacy and prognosis of autologous hematopoietic stem cell transplantation (ASCT) as frontline treatment for peripheral T cell lymphoma (PTCL). | 28222648 |
| Fecal Incontinence | Stem Cell Exhaustion | A new method for treating fecal incontinence by implanting stem cells derived from human adipose tissue: preliminary findings of a randomized double-blind clinical trial. | 28222801 |
| Fecal Incontinence | Stem Cell Exhaustion | Because human adipose-derived stromal/stem cells (hADSCs) are easier and safer to access, secrete high levels of growth factor, and have the potential to differentiate into muscle cells, we investigated the ability of hADSCs to improve anal sphincter incontinence. | 28222801 |
| MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Genetic abnormalities in myelodysplasia and secondary acute myeloid leukemia: impact on outcome of stem cell transplantation. | 28223278 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Genetic alterations, including mutations and copy-number alterations, are central to the pathogenesis of myelodysplastic syndromes and related diseases (myelodysplasia), but their roles in allogeneic stem cell transplantation have not fully been studied in a large cohort of patients. | 28223278 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Myelodysplastic syndrome (MDS) is a clonal stem cell disorder characterized by ineffective hematopoiesis with a high risk of transformation to acute myeloid leukemia (AML). | 28224273 |
| Neoplasms, Malignant Neoplasms | Stem Cell Exhaustion | miRNAs function as tumor suppressors and oncogenes in various cancers and regulate the differentiation potential of hematopoietic stem and progenitor cells (HSPCs). | 28224273 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Multivariable Cox analysis showed that old age, higher International Prognostic Scoring System (IPSS) subtypes, transformation to AML, no history of hematopoietic stem cell transplantation and short average interphase TL (<433 TL) as independent prognostic factors for poorer survival (P=0.003, 0.001, 0.005, 0.005, and 0.013, respectively). | 28224765 |
| Specialty Type - cancer, Gastrointestinal mucositis | Stem Cell Exhaustion | Oral mucositis is a common and often debilitating complication among cancer patients receiving radiation therapy to the head and neck or chemotherapy agents, or undergoing hematopoietic stem cell transplantation. | 28226414 |
| Clostridium difficile colitis | Stem Cell Exhaustion | Evaluation of Risk Factors for Clostridium difficile Infection in Hematopoietic Stem Cell Transplant Recipients. | 28226419 |
| Clostridium difficile colitis, Hematologic Neoplasms, Central Diabetes Insipidus | Stem Cell Exhaustion | The primary objective was to determine the impact of hematologic malignancies and/or conditioning regimens on the risk of developing Clostridium difficile infection (CDI) in patients undergoing hematopoietic stem cell transplantation (HSCT). | 28226419 |
| Multiple Myeloma | Stem Cell Exhaustion | High-dose chemotherapy and autologous stem cell transplantation of patients with multiple myeloma in an outpatient setting. | 28228122 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | High-dose (HD) chemotherapy with melphalan and autologous blood stem cell transplantation (ABSCT) for treatment of symptomatic multiple myeloma (MM) on an outpatient basis has been well established in the USA and Canada, whereas in Germany and Western Europe an inpatient setting is the current standard. | 28228122 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | Supersaturated Calcium Phosphate Rinse in Prevention and Treatment of Mucositis in Patients Undergoing Hematopoietic Stem Cell Transplant. | 28229803 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | Here, we assessed the efficacy of supersaturated calcium phosphate rinses in prevention and treatment of oral mucositis in patients undergoing hematopoietic stem cell transplant. | 28229803 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | In this retrospective study, we evaluated the records of 80 patients who underwent hematopoietic stem cell transplant and received supersaturated calcium phosphate rinses for preVention of mucositis from April 2012 to January 2016. | 28229803 |
| Specialty Type - cancer | Stem Cell Exhaustion | Given the current hypothesis that cancer arises from cancer stem cells (CSCs), targeting the critical signaling pathways that support CSC self-renewal appears to be a useful approach for cancer therapy. | 28230774 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Vildagliptin, but not glibenclamide, increases circulating endothelial progenitor cell number: a 12-month randomized controlled trial in patients with type 2 diabetes. | 28231835 |
| Diabetes | Stem Cell Exhaustion | Trial registration Clinical Trials number: NCT01822548; name: Effect of Vildagliptin vs. Glibenclamide on Circulating Endothelial Progenitor Cell Number Type 2 Diabetes. | 28231835 |
| Peripheral Blood Stem Cells | Stem Cell Exhaustion | We analyzed the impact of various graft sources and type of ABO mismatch on transplant outcomes for 1502 patients who underwent HCT at the University of Minnesota between 2000 and 2014: 312 receiving marrow (BM), 475 filgrastim-mobilized blood (peripheral blood stem cell [PBSC]), and 715 umbilical cord blood (UCB) grafts. | 28232088 |
| Hematologic Neoplasms | Stem Cell Exhaustion | To explore the lived experiences of patients with haematological malignancies who had been in protective isolation during their hospital stay for autologous haematopoietic stem cell transplantation. | 28233359 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Nine patients with haematological malignancies who had been in protective isolation for autologous haematopoietic stem cell transplantation were enrolled. | 28233359 |
| Parkinson Disease | Stem Cell Exhaustion | Idiopathic Parkinson's disease patient-derived induced pluripotent stem cells function as midbrain dopaminergic neurons in rodent brains. | 28233934 |
| Adult Myelodysplastic Syndrome, Leukemia, Myelocytic, Acute, Organ Dysfunction Scores | Stem Cell Exhaustion | Patients with GATA2 (Emberger syndrome) deficiency needs early hematopoietic stem cell transplant (HSCT) before evolving in to myelodysplastic syndrome or acute myeloid leukemia and with time given compromised organ dysfunction leads to increase regimen-related toxicities. | 28234738 |
| Specialty Type - cancer | Stem Cell Exhaustion | Furthermore, new evidence on the existence of tumour-specific cancer stem cells that are long-lived and more quiescent and radioresistant than non-stem cancer cells can raise questions about their association with SMN risk. | 28236557 |
| Malignant Neoplasms | Stem Cell Exhaustion | Associations were stronger for rarer cancers and at tissue sites with lower rates of stem cell division. | 28241208 |
| MS gene | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplantation (AHSCT) may be effective in aggressive forms of multiple sclerosis (MS) that fail to respond to standard therapies. | 28241268 |
| Specialty Type - cancer, Chromosome Aberrations | Stem Cell Exhaustion | Centrosome aberrations and changes in stem cell numbers were examined to assess cancer susceptibility. | 28245431 |
| Carcinoma, Neuroendocrine, Tubular adenoma | Stem Cell Exhaustion | Coexisting tubular adenoma with a neuroendocrine carcinoma of colon allowing early surgical intervention and implicating a shared stem cell origin. | 28246485 |
| Carcinoma, Neuroendocrine | Stem Cell Exhaustion | In addition, the finding of a high-grade NEC within a large TA in this case suggests a link between the two lesions and could represent a shared stem cell origin. | 28246485 |
| Specialty Type - cancer, leukemia | Stem Cell Exhaustion | Leukemia inhibitory factor (LIF) has multiple functions in stem cell biology, the immune response, and cancer, and is potentially a key molecule that allows cancer stem cells to self-renew. | 28247842 |
| Chordoma, Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cells, which are known to exist in chordomas, have extensive proliferative and self-renewal potential and are responsible for maintaining tumor heterogeneity along with chemotherapy and radiotherapy resistance. | 28247842 |
| Chordoma, Specialty Type - cancer | Stem Cell Exhaustion | Results indicate that LIF plays a role in maintaining cancer stem cells in chordomas. | 28247842 |
| Carcinoma, Neuroendocrine, Adenocarcinoma, Specialty Type - cancer | Stem Cell Exhaustion | The findings of this case suggest that adenocarcinoma and neuroendocrine carcinoma may be derived from a single cancer stem cell. | 28248881 |
| allergic inflammation | Stem Cell Exhaustion | Haemopoietic progenitor cells (HPC) migrate to sites of allergic inflammation where, upon stimulation with epithelial cytokines, they produce Th2 cytokines and differentiate into mature eosinophils and basophils. | 28252235 |
| Ischemic cardiomyopathy | Stem Cell Exhaustion | Effects of Transendocardial Stem Cell Injection on Ventricular Proarrhythmia in Patients with Ischemic Cardiomyopathy: Results from the POSEIDON and TAC-HFT Trials. | 28252842 |
| Ischemic cardiomyopathy, Ventricular arrhythmia, between breakfast and lunch | Stem Cell Exhaustion | Transendocardial stem cell injection in patients with ischemic cardiomyopathy (ICM) improves left ventricular function and structure but has ill-defined effects on ventricular arrhythmias. | 28252842 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | Rituximab with dose-adjusted EPOCH as first-line treatment in patients with highly aggressive diffuse large B-cell lymphoma and autologous stem cell transplantation in selected patients. | 28252874 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | To assess the benefit of rituximab with dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (R-DA-EPOCH) regimen as a first-line treatment for patients with diffuse large B-cell lymphoma (DLBCL) presenting with unfavorable or aggressive features, and autologous stem cell transplantation (ASCT) as a part of the first-line treatment for selected DLBCL patients with additional aggressive features. | 28252874 |
| V-Series Nerve Agent VM, Malignant Neoplasms, Specialty Type - cancer, Neoplasm Metastasis, Aggressive course, Secondary Neoplasm | Stem Cell Exhaustion | Vasculogenic mimicry (VM; blood supply development often seen in highly aggressive cancers), aldehyde dehydrogenase 1 (ALDH1, cancer stem cell biomarker), KiSS-1 (suppressor of tumor metastasis), and metastasis associated in colon cancer-1 (MACC1) are all useful predictive factors for metastasis and prognosis in various cancers. | 28253891 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Impact of ABO incompatibility on patients' outcome after haploidentical hematopoietic stem cell transplantation for acute myeloid leukemia - a report from the Acute Leukemia Working Party of the EBMT. | 28255020 |
| Acute GVH disease | Stem Cell Exhaustion | Focused analysis on stem cell source showed that patients with minor mismatching transplanted with bone marrow grafts experienced increased grade II-IV acute graft-versus-host disease rates (HR 2.03; 95% CI: 1.00-4.10; P=0.04). | 28255020 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Lactobacillus rhamnosus GG probiotic enteric regimen does not appreciably alter the gut microbiome or provide protection against GVHD after allogeneic hematopoietic stem cell transplantation. | 28256022 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease (GVHD) is a major adverse effect associated with allogeneic stem cell transplant. | 28256022 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Previous studies in mice indicated that administration of the probiotic Lactobacillus rhamnosus GG can reduce the incidence of GVHD after hematopoietic stem cell transplant. | 28256022 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Additional studies are necessary to determine whether probiotics can alter the incidence of GVHD after allogeneic stem cell transplant. | 28256022 |
| Liver and Intrahepatic Biliary Tract Carcinoma, Genotype | Stem Cell Exhaustion | This straightforward concept however, is increasing imperiled by the recognition of primary liver carcinomas that do not subscribe to a dichotomous paradigm of differentiation, and instead demonstrate biphenotypic differentiation, stem/progenitor cell like features or other variant patterns of differentiation. | 28256363 |
| Genotype, Intrahepatic Cholangiocarcinoma, Primary Neoplasm, Chronic liver disease, Liver carcinoma | Stem Cell Exhaustion | Similar to hepatocellular carcinoma and in contrast with intrahepatic cholangiocarcinoma, primary liver tumors showing biphenotypic differentiation, stem/progenitor cell features or variant differentiation occur mainly, but not always, on a background of chronic liver disease. | 28256363 |
| Neoplasms | Stem Cell Exhaustion | Tumour neovessels are mostly lined by endothelial cells sprouting from nearby capillaries, but they could also be contributed by circulating endothelial progenitor cells (EPCs). | 28258798 |
| Hollings Cancer Center | Stem Cell Exhaustion | Data analysis of stem cells related genes in CD133+ cells of the HCC group compared to the control group showed that; CCND2, COL1A1, CTNNA1, DLL3, JAG1, KRT15, MYC, NOTCH2, T and TERT were up-regulated (fold change=80, 68.6, 6.67, 7.22, 3.8, 15.2, 14.5, 105.6, 26.6 and 99 respectively while only CD3D was down-regulated (fold change=0.055) in HCC patients. | 28258914 |
| Erectile dysfunction | Stem Cell Exhaustion | Li-ESWT activation of local penile progenitor cells might be one of the mechanisms that contribute to the beneficial effects of shockwave treatment for erectile dysfunction, which represents a non-invasive alternative to exogenous stem cell therapy. | 28258952 |
| Mandibular Fractures | Stem Cell Exhaustion | This study aimed to assess the advantages of autologous stem cell use for atrophic mandibular fracture treatment in comparison to standard technique. | 28259617 |
| Cortical Dysplasia, Epilepsy | Stem Cell Exhaustion | Induced pluripotent stem cells from patients with focal cortical dysplasia and refractory epilepsy. | 28260047 |
| nervous system disorder, Disease | Stem Cell Exhaustion | The generation of induced pluripotent stem cells (iPSCs) from the cells of patients with neurological diseases, and their subsequent tissue-specific differentiation, serves as an invaluable source for testing and studying the initial development and subsequent progression of diseases associated with the central nervous system. | 28260047 |
| Hodgkin Disease, Lymphoma, Multiple Myeloma, Rhabdomyosarcoma, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Among 16 patients who received hematopoietic stem cell transplant between January 2003 and January 2010, one patient underwent allogeneic bone marrow transplant for acute myeloid leukemia and 15 patients received autologous bone marrow transplant for the following indications: 5 had multiple myeloma, 9 had lymphoma (8 with Hodgkin disease and 1 with non- Hodgkin lymphoma), and 1 had rhabdomyosarcoma. | 28260453 |
| Hodgkin Disease | Stem Cell Exhaustion | Our results show that high-dose chemotherapy followed by autologous stem cell transplant can induce long-term disease control in this cohort of patients with refractory or advanced Hodgkin disease; progression-free survival for our cohort was 50%, with survival comparable to those reported in the literature. | 28260453 |
| Diabetes Mellitus, Insulin-Dependent | Stem Cell Exhaustion | Leptin Levels in Patients with Type 1 Diabetes Mellitus After Fetal Pancreatic Stem Cell Transplant. | 28260466 |
| Diabetes Mellitus, Insulin-Dependent, Pancreas Transplantation | Stem Cell Exhaustion | Our objective was to determine leptin levels in patients with type 1 diabetes mellitus after fetal pancreatic stem cell transplant. | 28260466 |
| Diabetes Mellitus, Insulin-Dependent | Stem Cell Exhaustion | Seven patients, aged 20 to 42 years, with type 1 diabetes mellitus received a fetal pancreatic stem cell transplant by intravenous infusion. | 28260466 |
| Diabetes Mellitus, Insulin-Dependent | Stem Cell Exhaustion | Leptin levels increase significantly within 3 months of fetal pancreatic stem cell transplant in patients with type 1 diabetes mellitus. | 28260466 |
| Herpes Simplex Infections | Stem Cell Exhaustion | Acyclovir-resistant herpes simplex virus 1 infection early after allogeneic hematopoietic stem cell transplantation with T-cell depletion. | 28262533 |
| Herpes Simplex Infections, Infection | Stem Cell Exhaustion | We previously reported that oral low-dose acyclovir (200 mg/day) for the prevention of herpes simplex virus (HSV) infections after allogenic hematopoietic stem cell transplantation (HSCT) is effective without the emergence of acyclovir-resistant HSV infections. | 28262533 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Standard-dose 90yttrium-ibritumomab tiuxetan (.4 mci/kg) together with high-dose BEAM (BCNU, etoposide, cytarabine, and melphalan) (Z-BEAM) has been shown to be a well-tolerated autologous hematopoietic stem cell transplantation preparative regimen for non-Hodgkin lymphoma. | 28267593 |
| Myeloid Leukemia, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Although overexpression/activation of focal adhesion kinase (FAK) is widely known in solid tumors to control cell growth, survival, invasion, metastasis, gene expression, and stem cell self-renewal, its expression and function in myeloid leukemia are not well investigated. | 28270436 |
| Endometrial Carcinoma, Neoplasms | Stem Cell Exhaustion | There are few clinicopathologic studies with detailed immunohistochemical analysis regarding UCE/DCEs.We evaluated the diagnostic value of a selected tumor stem-cell marker and epithelial-mesenchymal transition (EMT) markers, in addition to previously studied markers in identifying UCE/DCEs from other types of high-grade endometrial carcinomas.Eleven cases of UCE/DCEs with complete clinical follow-up that were diagnosed between 2006 and 2015 were included in the study. | 28272224 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Patients with high TACC3 expression showed CD133+ stem cell properties, glioma plasticity and shorter overall survival time under chemo-/radio-therapy. | 28273854 |
| Tuberculosis | Stem Cell Exhaustion | The demanding attention of tuberculosis in allogeneic hematopoietic stem cell transplantation recipients: High incidence compared with general population. | 28278166 |
| Tuberculosis | Stem Cell Exhaustion | The risk of developing tuberculosis (TB) in allogeneic hematopoietic stem cell transplantation (HSCT) recipients is expected to be relatively high in an intermediate TB burden country. | 28278166 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Here, we report the first-in-human study exploiting a unique scalable NK-cell product generated ex vivo from CD34+ hematopoietic stem and progenitor cells (HSPC) from partially HLA-matched umbilical cord blood units.Experimental Design: Ten older AML patients in morphologic complete remission received an escalating HSPC-NK cell dose (between 3 and 30 x 106/kg body weight) after lymphodepleting chemotherapy without cytokine boosting.Results: HSPC-NK cell products contained a median of 75% highly activated NK cells, with <1 x 104 T cells/kg and <3 x 105 B cells/kg body weight. | 28280089 |
| Nasal Polyps | Stem Cell Exhaustion | During gene expression analysis and immunohistochemistry, we were able to detect different stem cell markers, like Oct-4, Sox2, Klf4, c-Myc, ABCG2, Nanog, CD133, and Nestin, which confirmed the existence of stem cell like cells within nasal polyps. | 28280847 |
| Nasal Polyps | Stem Cell Exhaustion | Our study demonstrated the expression of stem cell-related markers in nasal polyps. | 28280847 |
| Nasal Polyps | Stem Cell Exhaustion | Therefore, we investigated the stemness to determine the role of stem cells in nasal polyps, with additional analysis of the neuronal differentiation potential of nasal polyp cells. | 28280847 |
| Nasal Polyps | Stem Cell Exhaustion | We determined gene and protein expression profiles of stem cells in nasal polyp tissues, using whole genome microarray, quantitative real-time PCR (qPCR), immunohistochemistry, and flow cytometry. | 28280847 |
| Relapsing course | Stem Cell Exhaustion | A Phase I Trial of High-Dose Lenalidomide and Melphalan as Conditioning for Autologous Stem Cell Transplantation in Relapsed or Refractory Multiple Myeloma. | 28285081 |
| Multiple Myeloma | Stem Cell Exhaustion | Autologous stem cell transplantation (ASCT) conditioned with high-dose chemotherapy has long been established as the standard of care for eligible patients with newly diagnosed multiple myeloma. | 28285081 |
| Pulmonary Hypertension | Stem Cell Exhaustion | Very Small Embryonic-like Stem Cells Are Mobilized in Human Peripheral Blood during Hypoxemic COPD Exacerbations and Pulmonary Hypertension. | 28285391 |
| Squamous cell carcinoma of lung, Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Glioma-associated oncogene homolog 1 (Gli1) is involved in cancer stem cell (CSC) maintenance in various tumors; however, its expression and clinical significance in lung squamous cell carcinoma (LSCC) has not been reported. | 28286162 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplantation (auto-HSCT) has improved survival in patients with multiple myeloma (MM) and is increasingly used in elderly patients. | 28286198 |
| Steroid-Refractory Pneumonitis | Stem Cell Exhaustion | Mesenchymal stromal cell infusion to treat steroid-refractory acute GvHD III/IV after hematopoietic stem cell transplantation. | 28287644 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Acute GvHD (aGvHD) is a life-threatening complication of hematopoietic stem cell transplantation. | 28287644 |
| Periapical Diseases | Stem Cell Exhaustion | Expression of the stem cell factor in fibroblasts, endothelial cells, and macrophages in periapical tissues in human chronic periapical diseases. | 28290616 |
| Autosomal recessive inheritance, Pancytopenia | Stem Cell Exhaustion | In severe cases, usually inherited in an autosomal recessive pattern, the medullary cavity important in the production of normal blood cell progenitors is replaced by defective endochondral bone, leading to pancytopenia and consequential extramedullary hematopoiesis. | 28290981 |
| Lymphoma | Stem Cell Exhaustion | Patients with lymphoma that is chemotherapy refractory or relapsed after autologous stem-cell transplantation have a grim prognosis, and new treatments for these patients are clearly needed. | 28291388 |
| Chronic Obstructive Airway Disease, Pulmonary Emphysema | Stem Cell Exhaustion | We hypothesized that endothelial progenitor cell populations would be decreased in COPD and emphysema and that circulating endothelial cells would be increased. | 28291826 |
| Chronic Obstructive Airway Disease | Stem Cell Exhaustion | Among 257 participants, both endothelial progenitor cell populations, and particularly CD34+KDR+ endothelial progenitor cells, were reduced in COPD. | 28291826 |
| Panacinar Emphysema | Stem Cell Exhaustion | Both endothelial progenitor cell populations were associated inversely with extent of panlobular emphysema and positively with diffusing capacity. | 28291826 |
| Chronic Obstructive Airway Disease, Pulmonary Emphysema | Stem Cell Exhaustion | Endothelial progenitor cells in chronic obstructive pulmonary disease and emphysema. | 28291826 |
| Chronic Obstructive Airway Disease, Pulmonary Emphysema | Stem Cell Exhaustion | Endothelial injury is implicated in the pathogenesis of COPD and emphysema; however the role of endothelial progenitor cells (EPCs), a marker of endothelial cell repair, and circulating endothelial cells (CECs), a marker of endothelial cell injury, in COPD and its subphenotypes is unresolved. | 28291826 |
| Pulmonary Emphysema | Stem Cell Exhaustion | The CD34+KDR+CD133+ endothelial progenitor cells were associated inversely with emphysema extent. | 28291826 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Long-term follow-up of patients receiving allogeneic stem cell transplant for chronic lymphocytic leukaemia: mixed T-cell chimerism is associated with high relapse risk and inferior survival. | 28295181 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | There is limited information regarding the immunological predictors of post-allogeneic stem cell transplant (alloSCT) outcome in chronic lymphocytic leukaemia (CLL), such as mixed T-cell chimerism. | 28295181 |
| Multiple Myeloma | Stem Cell Exhaustion | Phase I study of cord blood-derived natural killer cells combined with autologous stem cell transplantation in multiple myeloma. | 28295190 |
| Gastric Carcinoid Tumor, Acute lymphocytic leukemia | Stem Cell Exhaustion | Development of a gastric carcinoid tumor following allogeneic hematopoietic stem cell transplantation for early T-cell precursor acute lymphoblastic leukemia. | 28295914 |
| Viral respiratory infection | Stem Cell Exhaustion | Respiratory virus infection after allogeneic hematopoietic stem cell transplant in a tropical center: Predictive value of the immunodeficiency scoring index. | 28295964 |
| Viral respiratory infection, Communicable Diseases | Stem Cell Exhaustion | Respiratory virus infection (RVI) is a prevalent infection in patients after allogeneic hematopoietic stem cell transplant (allo-HSCT) and can result in significant morbidity and mortality. | 28295964 |
| Hematologic Neoplasms, BK Virus, Hemorrhagic cystitis | Stem Cell Exhaustion | Nosocomial BK Polyomavirus Infection Causing Hemorrhagic Cystitis Among Patients With Hematological Malignancies After Hematopoietic Stem Cell Transplantation. | 28295968 |
| Hemorrhagic cystitis, Nephritis | Stem Cell Exhaustion | BK polyomavirus (BKPyV) is recognized as a pathogen that causes diseases such as hemorrhagic cystitis and nephritis after allogeneic hematopoietic stem cell transplantation (HSCT) or renal transplantation. | 28295968 |
| Phaeohyphomycosis | Stem Cell Exhaustion | Cutaneous phaeohyphomycosis in a hematopoietic stem cell transplant patient caused by Alternaria rosae: First case report. | 28295973 |
| Mycoses, Communicable Diseases | Stem Cell Exhaustion | Alternaria species have been reported as a rare cause of fungal infection in organ and stem cell transplant recipients, but to date, no reports have been published of infection in humans caused by Alternaria rosae. | 28295973 |
| Primary Myelofibrosis, Communicable Diseases | Stem Cell Exhaustion | Here, we report cutaneous A. rosae infection in a 66-year-old farmer with a history of primary myelofibrosis who had undergone allogeneic unrelated donor hematopoietic stem cell transplantation. | 28295973 |
| Prostate carcinoma, Secondary Neoplasm | Stem Cell Exhaustion | In vitro data suggest that adipose stromal/stem cells (ASCs) can increase production of cytokines and growth factors resulting in invasive growth and metastasis in prostate cancer. | 28296186 |
| methyldopa | Stem Cell Exhaustion | Vision Loss after Intravitreal Injection of Autologous "Stem Cells" for AMD. | 28296617 |
| Abnormal vision | Stem Cell Exhaustion | We evaluated three patients in whom severe bilateral visual loss developed after they received intravitreal injections of autologous adipose tissue-derived "stem cells" at one such clinic in the United States. | 28296617 |
| Hematologic Neoplasms, Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | There were 4 adult patients, of which 1 was actively receiving chemotherapy for chronic lymphocytic leukemia and 2 had undergone hematopoietic stem cell transplantation for hematologic malignancies. | 28296681 |
| Adult Glioblastoma | Stem Cell Exhaustion | Here, we show that m6A mRNA modification is critical for glioblastoma stem cell (GSC) self-renewal and tumorigenesis. | 28297667 |
| Adult Glioblastoma, Neoplastic Cell Transformation | Stem Cell Exhaustion | m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells. | 28297667 |
| Specialty Type - cancer | Stem Cell Exhaustion | However, the functions of N6-methyladenosine (m6A) mRNA modification in cancer biology and cancer stem cells remain largely unknown. | 28297667 |
| Intraepithelial Neoplasia, Intraductal Hyperplasia | Stem Cell Exhaustion | Multicolor immunofluorescence reveals that p63- and/or K5-positive progenitor cells contribute to normal breast epithelium and usual ductal hyperplasia but not to low-grade intraepithelial neoplasia of the breast. | 28303349 |
| Usual ductal hyperplasia | Stem Cell Exhaustion | Usual ductal hyperplasia showed striking similarity to normal luminal breast epithelium including p63+ and/or K5+ luminal progenitor cells and the full spectrum of luminal progeny cells. | 28303349 |
| Intraepithelial Neoplasia, Intraductal Hyperplasia | Stem Cell Exhaustion | From our data we conclude that p63+ and/or K5+ progenitor cells contribute to maintenance of normal epithelium and usual ductal hyperplasia, but not to low-grade intraepithelial neoplasia of the breast. | 28303349 |
| Aplastic Anemia | Stem Cell Exhaustion | Vascular and perivascular niches, but not the osteoblastic niche, are numerically restored following allogeneic hematopoietic stem cell transplantation in patients with aplastic anemia. | 28303517 |
| Squamous cell carcinoma | Stem Cell Exhaustion | Induced Pluripotent-stem-cell Related Genes Contribute to De-differentiation in Oral Squamous Cell Carcinoma. | 28314267 |
| Malignant Neoplasms | Stem Cell Exhaustion | Hypoxia affects cell differentiation and induces stem-cell-like characteristics in malignancies. | 28314267 |
| Specialty Type - cancer, Neoplasms, Malignant Neoplasms | Stem Cell Exhaustion | Cancer stem cells are suspected to contribute to malignancy in tumors. | 28314267 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We used a targeted 28-gene NGS panel to detect mutations and different-from-normal 10-color MFC to measure MRD in AML patients before allogeneic hematopoietic stem cell transplantation (HCT). | 28315400 |
| FLT3 Internal Tandem Duplication | Stem Cell Exhaustion | FLT3-ITD mutations were detected in 33% of patients (2/6); 80% (4/5) of mutant patients died even after hematopoietic stem cell transplantation. | 28318095 |
| FLT3 Internal Tandem Duplication, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The retrospective study included 60 de novo adult AML patients diagnosed at our institution with normal karyotype, no FLT3-ITD or NPM1 mutations, and who did not receive allogeneic hematopoietic stem cell transplantations. | 28318150 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We report an autopsied case showing PRES-like neuroradiological findings associated with premedication including tacrolimus for autologous peripheral blood stem cell transplantation in a 28-year-old woman with a 2-year history of acute myeloid sarcoma/acute myeloid leukemia. | 28320172 |
| Sample Size Calculation | Stem Cell Exhaustion | Enhanced numbers of EMPs, CFU-ECs and non-haematopoietic CD34+CD45- endothelial progenitor cells (EPCs) were observed in patients with SSc. | 28320472 |
| Allergic Reaction | Stem Cell Exhaustion | There were no infusional or allergic reactions and no difference in treatment-emergent adverse events between the groups (64 [99%] of 65 patients in the multipotent adult progenitor cell group vs 59 [97%] of 61 in the placebo group). | 28320635 |
| Cerebrovascular accident | Stem Cell Exhaustion | There was no difference between the multipotent adult progenitor cell group and placebo groups in global stroke recovery at day 90 (odds ratio 1*08 [95% CI 0*55-2*09], p=0*83). | 28320635 |
| Ischemic stroke | Stem Cell Exhaustion | Safety and efficacy of multipotent adult progenitor cells in acute ischaemic stroke (MASTERS): a randomised, double-blind, placebo-controlled, phase 2 trial. | 28320635 |
| Acute Cerebrovascular Accidents | Stem Cell Exhaustion | Multipotent adult progenitor cells are a bone marrow-derived, allogeneic, cell therapy product that modulates the immune system, and represents a promising therapy for acute stroke. | 28320635 |
| Cerebrovascular accident | Stem Cell Exhaustion | We aimed to identify the highest, well-tolerated, and safest single dose of multipotent adult progenitor cells, and if they were efficacious as a treatment for stroke recovery. | 28320635 |
| Ischemic stroke, Cerebrovascular accident | Stem Cell Exhaustion | We used a computer-generated randomisation sequence and interactive voice and web response system to assign patients aged 18-83 years with moderately severe acute ischaemic stroke and a National Institutes of Health Stroke Scale (NIHSS) score of 8-20 to treatment with intravenous multipotent adult progenitor cells (400 million or 1200 million cells) or placebo between 24 h and 48 h after symptom onset. | 28320635 |
| Ischemic stroke | Stem Cell Exhaustion | Administration of multipotent adult progenitor cells was safe and well tolerated in patients with acute ischaemic stroke. | 28320635 |
| Cerebrovascular accident | Stem Cell Exhaustion | Although no significant improvement was observed at 90 days in neurological outcomes with multipotent adult progenitor cells treatment, further clinical trials evaluating the efficacy of the intervention in an earlier time window after stroke (<36 h) are planned. | 28320635 |
| Aplastic Anemia | Stem Cell Exhaustion | Epstein-Barr virus (EBV)-associated lymphoproliferative disorders (LPDs) sometimes occur following Anti-thymocyte globulin (ATG) administration for allogenic stem cell transplantation but are rare in aplastic anemia (AA) patients. | 28321074 |
| Liver carcinoma, Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | AURKA promotes cancer metastasis by regulating epithelial-mesenchymal transition and cancer stem cell properties in hepatocellular carcinoma. | 28322787 |
| Specialty Type - cancer, Hollings Cancer Center | Stem Cell Exhaustion | While overexpression of AURKA induced epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) behaviors though PI3K/AKT pathway, silencing AURKA suppressed radiation-enhanced cell invasiveness of HCC. | 28322787 |
| Cerebrovascular accident | Stem Cell Exhaustion | However, it is essential to understand the traits of iSCs in the poststroke human brain for possible applications in stem cell-based therapies for stroke patients. | 28323540 |
| Cerebrovascular accident | Stem Cell Exhaustion | Identification of Multipotent Stem Cells in Human Brain Tissue Following Stroke. | 28323540 |
| Ischemia | Stem Cell Exhaustion | We previously demonstrated that brain pericytes near blood vessels also develop multipotency following experimental ischemia in mice and these ischemia-induced multipotent stem cells (iSCs) can contribute to neurogenesis. | 28323540 |
| Pancytopenia | Stem Cell Exhaustion | Given that TPO receptors are reportedly expressed in not only megakaryocyte progenitor cells but also hematopoietic progenitors, lusutrombopag may potentially improve pancytopenia caused by LC and can be used for the recovery of blood counts before other treatments. | 28324272 |
| Comorbidity, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Cytogenetics and comorbidity predict outcomes in older myelodysplastic syndrome patients after allogeneic stem cell transplantation using reduced intensity conditioning. | 28324640 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only treatment with a curative potential for myelodysplastic syndrome (MDS) patients. | 28324640 |
| Hollings Cancer Center | Stem Cell Exhaustion | The aim of this study was to evaluate the diagnostic value of serum Wisteria Floribunda agglutinin-positive sialylated mucin 1 (WFA-sialylated MUC1), which is a novel biliary marker, as a marker of HCC with hepatic progenitor cell (HPC)/biliary features and of prognosis. | 28325920 |
| Malignant neoplasm of stomach, Specialty Type - cancer | Stem Cell Exhaustion | Polymorphisms of cancer stem cell marker gene CD133 are associated with susceptibility and prognosis of gastric cancer. | 28326835 |
| Malignant neoplasm of stomach, Specialty Type - cancer | Stem Cell Exhaustion | This study was aimed to investigate the associations between single nucleotide polymorphisms of cancer stem cell marker genes, CD44 and CD133, and susceptibility and prognosis of gastric cancer. | 28326835 |
| Hodgkin Disease | Stem Cell Exhaustion | Risk factors and a prognostic score for survival after autologous stem-cell transplantation for relapsed or refractory Hodgkin lymphoma. | 28327958 |
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Stem Cell Exhaustion | We present a case study of a 3-year-old girl with precursor T-cell acute lymphoblastic leukemia who received intravenous busulfan before hematopoietic stem cell transplantation. | 28328762 |
| Bone marrow hypocellularity, Anemia, Hemolytic, Thromboembolism, Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0 | Stem Cell Exhaustion | Paroxysmal nocturnal hemoglobinuria (PNH) is a nonmalignant acquired hematopoietic stem cell disease, which can be revealed by hemolytic anemia, thromboembolism, or bonemarrow failure. | 28328837 |
| Clostridium difficile colitis | Stem Cell Exhaustion | Evaluating Risk Factors for Clostridium difficile Infection In Stem Cell Transplant Recipients: A National Study. | 28330512 |
| Clostridium difficile colitis, Dysentery, Central Diabetes Insipidus | Stem Cell Exhaustion | OBJECTIVE Large-scale studies evaluating risk factors for Clostridium difficile infection (CDI), a leading cause of infectious diarrhea among patients undergoing stem cell transplantation (SCT), are lacking. | 28330512 |
| Lymphoma, Follicular, Mucosa-associated lymphoid tissue (MALT) lymphoma of orbit | Stem Cell Exhaustion | Orbital MALT Lymphoma after Autologous Stem Cell Transplantation for Follicular Lymphoma as Relapse of Diffuse Large B-Cell Lymphoma. | 28331132 |
| Lymphoma, Follicular, B-Cell Lymphomas, Mucosa-associated lymphoid tissue (MALT) lymphoma of orbit | Stem Cell Exhaustion | We report a patient who developed orbital MALT lymphoma after autologous peripheral blood stem cell transplantation for follicular lymphoma as relapse of diffuse large B-cell lymphoma. | 28331132 |
| Lymphoma, Mucosa-Associated Lymphoid Tissue Lymphoma | Stem Cell Exhaustion | Relapse as MALT lymphoma after hematopoietic stem cell transplantation for relapsed and refractory lymphoma may not be a poor prognostic sign. | 28331132 |
| Chronic granulomatous disease | Stem Cell Exhaustion | Disseminated Lichtheimia ramosa Infection After Hematopoietic Stem Cell Transplantation in a Child With Chronic Granulomatous Disease. | 28333712 |
| Chronic granulomatous disease, Thrombosis | Stem Cell Exhaustion | We report a 7-year-old boy with X-linked CGD and absent oxidative burst who developed fatal Lichtheimia ramosa infection with fungal thrombosis of the kidneys, spleen and other organs after hematopoietic stem cell transplantation. | 28333712 |
| Malignant Peripheral Nerve Sheath Tumor, Myeloproliferative disease | Stem Cell Exhaustion | Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell (HSC) disorders that can be classified on the basis of genetic, clinical, phenotypic features. | 28335073 |
| Limbal stem cell deficiency | Stem Cell Exhaustion | Paediatric idiopathic limbal stem cell deficiency. | 28336223 |
| Inflammation, Trauma, Hypersensitivity | Stem Cell Exhaustion | Acquired limbal stem cell deficiency (LSCD) describes a condition in which the corneal limbal stem cells are altered or destroyed, typically due to ocular trauma, chronic allergy or inflammation. | 28336223 |
| Failure | Stem Cell Exhaustion | Idiopathic LSCD is a term used to describe limbal stem cell failure in the absence of any identifiable causative factor. | 28336223 |
| Unknown (origin) (qualifier value) | Stem Cell Exhaustion | While several cases of adult-onset LSCD have been identified previously, this case report describes a rare presentation of bilateral asymmetric idiopathic paediatric limbal stem cell deficiency in a sixteen-year-old male with an otherwise unremarkable ocular history. | 28336223 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Allogeneic Hematopoietic Stem Cell Transplantation Is Underutilized in Older Patients with Myelodysplastic Syndromes. | 28336325 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (HCT) is the only curative treatment for myelodysplastic syndrome (MDS). | 28336325 |
| Thrombosis of blood vessel | Stem Cell Exhaustion | Deficiency of circulating progenitor cells associated with vascular thrombosis of hemodialysis patients. | 28339557 |
| HD Term Type | Stem Cell Exhaustion | Endothelial progenitor cells (EPCs), which function in vascular repair, are deficient in HD patients. | 28339557 |
| Adult T-Cell Lymphoma/Leukemia | Stem Cell Exhaustion | Although allogeneic stem cell transplantation after chemotherapy is a recommended treatment option for patients with aggressive adult T-cell leukemia-lymphoma, there is no consensus about indications for allogeneic stem cell transplantation because there is no established risk stratification system for transplant eligible patients. | 28341734 |
| Adult T-Cell Lymphoma/Leukemia | Stem Cell Exhaustion | We developed a promising new risk stratification system to identify patients aged 70 years or younger with aggressive adult T-cell leukemia-lymphoma who may benefit from upfront allogeneic stem cell transplantation. | 28341734 |
| Leukemic Hematopoietic Stem Cell | Stem Cell Exhaustion | Gene set enrichment analysis showed higher HOPX expression was associated with both hematopoietic and leukemia stem cell signatures. | 28341738 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | While HOPX and HOX family genes showed concordant expression patterns in normal hematopoietic stem/progenitor cells, their expression patterns and associated clinical and biological features were distinctive in AML settings, demonstrating HOPX to be a unique homeobox gene. | 28341738 |
| Shwachman syndrome | Stem Cell Exhaustion | First experience of hematopoietic stem cell transplantation treatment of Shwachman-Diamond syndrome using unaffected HLA-matched sibling donor produced through preimplantation HLA typing. | 28346418 |
| Allogeneic Hematopoietic Stem Cell Transplantation, Bone marrow hypocellularity, Shwachman syndrome | Stem Cell Exhaustion | The only proven cure for Shwachman-Diamond syndrome (SDS) bone marrow failure is allogeneic hematopoietic stem cell transplantation (HSCT). | 28346418 |
| Retinal Diseases | Stem Cell Exhaustion | Retina tissue engineering by conjunctiva mesenchymal stem cells encapsulated in fibrin gel: Hypotheses on novel approach to retinal diseases treatment. | 28351499 |
| Disease, physiopathological, methyldopa | Stem Cell Exhaustion | Our hypothesis suggests that using human conjunctiva stem cells (as the source for increasing the number of human stem cells progenitor cells in retina dysfunction diseases) with fibrin gel and also assessing its relating in vitro (cellular and molecular processes) and in vivo (vision tests and pathology) could be a promising strategy for treatment of AMD and RP disorders. | 28351499 |
| Reticulon-4 Receptor-Like 1, Human | Stem Cell Exhaustion | In this idea, we describe a novel approach for retina tissue engineering with differentiation of conjunctiva mesenchymal stem cells (CJMSCs) into photoreceptor-like cells in fibrin gel with induction medium contain taurine. | 28351499 |
| Retinal Degeneration | Stem Cell Exhaustion | In retinal transplantation studies, stem and progenitor cells inject into the sub retinal space or vitreous and then these cells can be migrate to the site of retinal degeneration and locate in the host retina and restitute vision. | 28351499 |
| Acute leukemia | Stem Cell Exhaustion | Endoglin (CD105), a receptor of the transforming growth factor-b superfamily, has been reported to identify functional long-term repopulating hematopoietic stem cells, and has been detected in certain subtypes of acute leukemias. | 28351936 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | In multiple myeloma (MM), relapse is a problem after autologous hematopoietic stem cell transplantation (ASCT). | 28355602 |
| Neutropenia, B-Cell Lymphomas | Stem Cell Exhaustion | Incidence of late onset neutropenia associated with rituximab use in B cell lymphoma patients undergoing autologous stem cell transplantation. | 28358279 |
| Neutropenia, B-Cell Lymphomas | Stem Cell Exhaustion | Reversible late onset neutropenia associated with rituximab has been reported with incidence rates varying from 15 to 70% in B cell lymphoma patients receiving autologous stem cell transplantation. | 28358279 |
| B-Cell Lymphomas | Stem Cell Exhaustion | We conducted a retrospective descriptive study at one tertiary care center in adult B cell lymphoma patients treated with rituximab and autologous stem cell transplantation between 1 January 2004 and 30 June 2014. | 28358279 |
| Neutropenia | Stem Cell Exhaustion | Late onset neutropenia was defined as an absolute neutrophil count <1.0 x 109 cells/L after neutrophil engraftment and less than six months post autologous stem cell transplantation. | 28358279 |
| Neutropenia | Stem Cell Exhaustion | In conclusion, rituximab with mobilization or high dose chemotherapy may increase the risk of late onset neutropenia post autologous stem cell transplantation. | 28358279 |
| Non-Small Cell Lung Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Nestin is a class VI intermediate filament protein expressed in neural stem cells and several cancer cells including NSCLC. | 28358810 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | The aim of this study was to analyze the influence of dietary supplementation with whey protein concentrate (WPC) in the incidence of oral mucositis (OM) in patients undergoing hematopoietic stem cell transplantation (HSCT). | 28359354 |
| Agranulocytosis lab result | Stem Cell Exhaustion | The observation of colony forming units of progenitor cells in dishes that contained the patient's serum, provided inconclusive explanation of the possible mechanism of DFP-induced agranulocytosis. | 28361596 |
| Somatic mosaicism, Nevoid, Basal Cell Nevus Syndrome | Stem Cell Exhaustion | Somatic mosaicism containing double mutations in PTCH1 revealed by generation of induced pluripotent stem cells from nevoid basal cell carcinoma syndrome. | 28363938 |
| Multiple Myeloma | Stem Cell Exhaustion | Multiple myeloma patients in long-term complete response after autologous stem cell transplantation express a particular immune signature with potential prognostic implication. | 28368375 |
| Multiple Myeloma | Stem Cell Exhaustion | The proportion of multiple myeloma patients in long-term complete response (LTCR-MM) for more than 6 years after autologous stem cell transplantation (ASCT) is small. | 28368375 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Prognostic impact of the European LeukemiaNet standardized reporting system in older AML patients receiving stem cell transplantation after non-myeloablative conditioning. | 28368377 |
| Neoplasm Metastasis | Stem Cell Exhaustion | Significant risk factors for the development of t-AML/MDS after autologous and allogeneic HCT were high-stage risk at HCT (P=0.04) or secondary malignancies (P<0.001) and receiving cord blood stem cell (P=0.03) or involved field radiotherapy (P=0.002), respectively. | 28368379 |
| Congenital infectious disease, Milk (body substance), Vitreous humor | Stem Cell Exhaustion | Next-generation sequencing was performed on target enriched sequence libraries prepared directly from a variety of clinical specimens (blood, urine, breast milk, respiratory samples, biopsies, and vitreous humor) obtained longitudinally or from different anatomical compartments from 20 HCMV-infected patients (renal transplant recipients, stem cell transplant recipients, and congenitally infected children). | 28368496 |
| MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Feasibility of allogeneic stem-cell transplantation after azacitidine bridge in higher-risk myelodysplastic syndromes and low blast count acute myeloid leukemia: results of the BMT-AZA prospective study. | 28368509 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Allogeneic stem-cell transplantation (HSCT) is the only curative treatment in myelodysplastic syndromes (MDS). | 28368509 |
| Infection of bloodstream | Stem Cell Exhaustion | Prediction of Bloodstream Infection Due to Vancomycin-Resistant Enterococcus in Patients Undergoing Leukemia Induction or Hematopoietic Stem-Cell Transplantation. | 28369204 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Allogeneic stem cell transplantation in patients with atypical chronic myeloid leukaemia: a retrospective study from the Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation. | 28369779 |
| Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative, Aggressive course, Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Atypical chronic myeloid leukaemia (aCML) is an aggressive malignancy for which allogeneic haematopoietic stem cell transplantation (allo-HSCT) represents the only curative option. | 28369779 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | High-dose chemotherapy with thiotepa, busulfan, and cyclophosphamide and autologous stem cell transplantation for patients with primary central nervous system lymphoma in first complete remission. | 28369839 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | High-dose chemotherapy and autologous stem cell transplantation (HDC-ASCT) is a therapeutic option for patients with primary central nervous system lymphoma (PCNSL). | 28369839 |
| Primary Myelofibrosis | Stem Cell Exhaustion | Is allogeneic stem cell transplantation for myelofibrosis still indicated at the time of molecular markers and JAK inhibitors era? | 28370306 |
| Primary Myelofibrosis | Stem Cell Exhaustion | The role of allogenic stem cell transplantation (ASCT) is still debated in myelofibrosis (MF). | 28370306 |
| Acute leukemia, Leukemia, Myelocytic, Acute, Leukocytosis | Stem Cell Exhaustion | Long term impact of hyperleukocytosis in newly diagnosed acute myeloid leukemia patients undergoing allogeneic stem cell transplantation: An analysis from the acute leukemia working party of the EBMT. | 28370339 |
| Leukemia, Myelocytic, Acute, Leukocytosis | Stem Cell Exhaustion | Yet, it is unknown whether hyperleukocytosis still retains prognostic value for AML patients undergoing hematopoietic stem cell transplantation (HSCT). | 28370339 |
| Multiple Myeloma | Stem Cell Exhaustion | Cyclophosphamide-based stem cell mobilization in relapsed multiple myeloma patients: A subgroup analysis from the phase III trial ReLApsE. | 28370401 |
| Toxic effect, Multiple Myeloma | Stem Cell Exhaustion | Analysis of the efficiency and toxicity of cyclophosphamide-based stem cell mobilization in patients with relapsed multiple myeloma (RMM). | 28370401 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Since a study published in 2002 showed a survival advantage of melphalan-only conditioning for stem cell transplantation (HSCT) over melphalan-total body irradiation (mel-TBI) in patients with multiple myeloma (MM), most centers abandoned mel-TBI. | 28370630 |
| Specialty Type - cancer | Stem Cell Exhaustion | Finally, we observed that increased stromal TILs and PDL1 expression were significantly associated with cancer stem cell (CSC) markers, basal cell markers and vimentin expression. | 28373294 |
| Vaginal Hemorrhage | Stem Cell Exhaustion | Continuation of hormonal intrauterine devices (IUDs) - widely used and highly effective contraceptives that also decrease menstrual flow - is controversial during hematopoietic stem cell transplants (SCTs) due to infectious and vaginal bleeding concerns. | 28373471 |
| Malignant tumor of colon, Specialty Type - cancer | Stem Cell Exhaustion | Cancer Stem Cell Gene Variants in CD44 Predict Outcome in Stage II and Stage III Colon Cancer Patients. | 28373475 |
| Mastocytosis, Specialty Type - cancer, Malignant Neoplasms, Malignant tumor of colon | Stem Cell Exhaustion | Growing evidence suggests that human cancers are stem cell diseases and recent data support the existence of cancer stem cells (CSCs) in a variety of malignancies, including colon cancer. | 28373475 |
| Malignant tumor of colon | Stem Cell Exhaustion | The purpose of the present study was to assess the impact of single-nucleotide polymorphisms (SNPs) in stem cell-related genes on clinical outcome in a large cohort of colon cancer patients with clinical stage II and III. | 28373475 |
| Malignant tumor of colon | Stem Cell Exhaustion | Germline variants rs13347 and rs187115 in the stem cell gene CD44 are prognostically relevant in stage II and III colon cancer patients. | 28373475 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Enumeration and Localization of Mesenchymal Progenitor Cells and Macrophages in Synovium from Normal Individuals and Patients with Pre-Osteoarthritis or Clinically Diagnosed Osteoarthritis. | 28379175 |
| Cartilage damage | Stem Cell Exhaustion | Few studies have examined the cellular composition (inflammatory cells and/or progenitor cells) in the synovium of patients with pre-OA (asymptomatic with cartilage damage). | 28379175 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Therefore, in the current study, mesenchymal progenitor cells (MPCs) and macrophages were enumerated within normal, pre-OA and OA synovium. | 28379175 |
| Multiple Myeloma | Stem Cell Exhaustion | High-dose chemotherapy plus autologous stem-cell transplantation has been the standard treatment for newly diagnosed multiple myeloma in adults up to 65 years of age. | 28379796 |
| Multiple Myeloma | Stem Cell Exhaustion | We randomly assigned 700 patients with multiple myeloma to receive induction therapy with three cycles of RVD and then consolidation therapy with either five additional cycles of RVD (350 patients) or high-dose melphalan plus stem-cell transplantation followed by two additional cycles of RVD (350 patients). | 28379796 |
| Malignant Neoplasms | Stem Cell Exhaustion | Expression of mesenchymal stem cell markers contributed to the inherent heterogeneity in the malignant tumors. | 28380418 |
| Carcinogenesis | Stem Cell Exhaustion | Overall, we found that progastrin binds to GPR56 expressing colonic stem cells, which in turn promotes their expansion, and that this GPR56-dependent pathway is an important driver and potential new target in colorectal carcinogenesis. | 28380450 |
| Specialty Type - cancer | Stem Cell Exhaustion | Dicer1 and cancer stem cells play important roles in cell motility and survival. | 28381177 |
| Cardiomyopathies | Stem Cell Exhaustion | Phase I Clinical Trial of Autologous Stem Cell-Sheet Transplantation Therapy for Treating Cardiomyopathy. | 28381469 |
| Specialty Type - cancer, Intestinal Neoplasms, Malignant neoplasm of prostate | Stem Cell Exhaustion | Recently, DCLK1 has been reported to act as an intestinal tumor stem cell marker and has been shown to be expressed in cancer cells and in the stroma of breast, colon, pancreatic, and prostate cancers. | 28382517 |
| Bone Diseases | Stem Cell Exhaustion | This phase II study explored the effects of bortezomib consolidation versus observation on myeloma-related bone disease in patients who had a partial response or better after frontline high-dose therapy and autologous stem cell transplantation. | 28382618 |
| LACRIMAL DUCT DEFECT | Stem Cell Exhaustion | Cardiac involvement by LCDD was seen in one-third of our patients and was associated with shorter overall survival; such patients also had a significantly higher risk of treatment-related mortality (TRM) after stem cell transplant (SCT) compared to LCDD patients without cardiac involvement. | 28383130 |
| Aggressive behavior, Specialty Type - cancer | Stem Cell Exhaustion | Meanwhile, cancer stem cells (CSCs) are also characterized by a strong tumorigenic potential, which might be partly responsible for the aggressive behavior of TNBC. | 28383433 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | SRT1720 promotes survival of aged human mesenchymal stem cells via FAIM: a pharmacological strategy to improve stem cell-based therapy for rat myocardial infarction. | 28383554 |
| Humor | Stem Cell Exhaustion | We have shown previously that transplantation of induced pluripotent stem cell (iPSC) derived TM cells restores aqueous humor dynamics in young transgenic mice expressing a pathogenic form of human myocilin (Tg-MYOCY437H). | 28384726 |
| Glaucoma, CTCAE | Stem Cell Exhaustion | This type of stem cell-based therapy is a promising possibility for restoration of IOP control in some glaucoma patients. | 28384726 |
| Myeloid Leukemia, Chronic, BCR gene | Stem Cell Exhaustion | The objective of this study was to compare overall survival (OS) between patients with CML and those with Ph+ ALL who received treatment with ponatinib versus allogeneic stem cell transplantation (allo-SCT). | 28387926 |
| Primary Myelofibrosis | Stem Cell Exhaustion | Impact of Molecular Genetics on Outcome in Myelofibrosis Patients after Allogeneic Stem Cell Transplantation. | 28389256 |
| Primary Myelofibrosis, Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase | Stem Cell Exhaustion | To determine the impact of molecular genetics on outcome after allogeneic stem cell transplantation, we screened 169 patients with primary myelofibrosis (n = 110), post-essential thrombocythemia/polycythemia vera myelofibrosis (n = 46), and myelofibrosis in transformation (n = 13) for mutations in 16 frequently mutated genes. | 28389256 |
| Primary Myelofibrosis | Stem Cell Exhaustion | Molecular genetics, especially CALR, IDH2, and ASXL1 mutations, may thus be useful to predict outcome independently from known clinical risk factors after allogeneic stem cell transplantation for myelofibrosis. | 28389256 |
| Central Nervous System, graft loss, Vertigo , Diplopia | Stem Cell Exhaustion | Seven months later, he developed central nervous system PTLD, presenting with vertigo and diplopia; immunosuppression was discontinued, resulting in graft loss, and he was given high-dose methotrexate and underwent consolidative autologous stem cell transplantation. | 28390107 |
| Lymphoma | Stem Cell Exhaustion | Allogeneic Stem Cell Transplantation for Relapsed/Refractory B Cell Lymphomas: Results of a Multicenter Phase II Prospective Trial including Rituximab in the Reduced-Intensity Conditioning Regimen. | 28390983 |
| S100A4 protein, human | Stem Cell Exhaustion | The prevention of oncogene-induced DNA damage precludes induction of the oncosuppressive p53-dependent DNA-damage response, thereby increasing stem cells' intrinsic susceptibility to malignant transformation. | 28394329 |
| Amyloidosis | Stem Cell Exhaustion | Revisiting conditioning dose in newly diagnosed light chain amyloidosis undergoing frontline autologous stem cell transplant: impact on response and survival. | 28394369 |
| Amyloidosis | Stem Cell Exhaustion | Autologous stem cell transplantation (ASCT) is an important treatment modality in light chain (AL) amyloidosis. | 28394369 |
| Amyloidosis | Stem Cell Exhaustion | Stem cell transplantation in patients with systemic AL amyloidosis referred for transplant after suboptimal responses to bortezomib-based initial therapy. | 28394371 |
| Blood Vessel | Stem Cell Exhaustion | Endothelial progenitor cells (EPCs) play a role in vascular repair, while circulating endothelial cells (CECs) are biomarkers of vascular damage and regeneration. | 28394933 |
| Neoplasms | Stem Cell Exhaustion | High-dose chemotherapy with autologous stem cell rescue is commonly used for the treatment of relapsed germ cell tumors. | 28395668 |
| Rhabdomyolysis, Myalgia | Stem Cell Exhaustion | His course was complicated by muscle pain and rhabdomyolysis after cycle 4 on day +12 after infusion of autologous stem cells. | 28395668 |
| Rett Syndrome | Stem Cell Exhaustion | Generation of a clonal induced pluripotent stem cell (iPSC) line expressing the mutant MECP2 allele from a Rett Syndrome patient fibroblast line. | 28395743 |
| Hypertrophic Cardiomyopathy | Stem Cell Exhaustion | Peripheral blood derived induced pluripotent stem cells (iPSCs) from a female with familial hypertrophic cardiomyopathy. | 28395744 |
| Hypertrophic Cardiomyopathy, Health maintenance | Stem Cell Exhaustion | Induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells (PBMCs) obtained from a 62-year-old female with familial hypertrophic cardiomyopathy (HCM). | 28395744 |
| alpha-Thalassemia | Stem Cell Exhaustion | In this study the MUi009-A human induced pluripotent stem cell line was successfully generated from peripheral blood CD34+ haematopoietic progenitors of a 32year old male who had coinherited a homozygous bdeg-thalassemia mutation at codon 41/42 (-TCTT) and a heterozygous a-thalassemia 4.2 deletion. | 28395745 |
| alpha-Thalassemia | Stem Cell Exhaustion | Establishment of MUi009 - A human induced pluripotent stem cells from a 32year old male with homozygous bdeg-thalassemia coinherited with heterozygous a-thalassemia 2. | 28395745 |
| Hypertrophic Cardiomyopathy | Stem Cell Exhaustion | Generation of induced pluripotent stem cells (iPSCs) from a hypertrophic cardiomyopathy patient with the pathogenic variant p.Val698Ala in beta-myosin heavy chain (MYH7) gene. | 28395747 |
| Hypertrophic Cardiomyopathy, Health maintenance | Stem Cell Exhaustion | Induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells (PBMCs) isolated from the whole blood of a 43-year-old male with hypertrophic cardiomyopathy (HCM) who carries the pathogenic variant p.Val698Ala in beta-myosin heavy chain (MYH7). | 28395747 |
| Parkinson Disease | Stem Cell Exhaustion | Reprogramming of a human induced pluripotent stem cell (iPSC) line from a Parkinson's disease patient with a R1628P variant in the LRRK2 gene. | 28395802 |
| Parkinson Disease | Stem Cell Exhaustion | Derivation of human induced pluripotent stem cell (iPSC) line with LRRK2 gene R1398H variant in Parkinson's disease. | 28395803 |
| Parkinson Disease | Stem Cell Exhaustion | Development of a human induced pluripotent stem cell (iPSC) line from a Parkinson's disease patient carrying the N551K variant in LRRK2 gene. | 28395804 |
| Parkinson Disease | Stem Cell Exhaustion | Generation of a human induced pluripotent stem cell (iPSC) line carrying the Parkinson's disease linked LRRK2 variant S1647T. | 28395805 |
| Multiple Endocrine Neoplasia | Stem Cell Exhaustion | Generation of non-integrated induced pluripotent stem cells from a 59-year-old female with multiple endocrine neoplasia type 1 syndrome. | 28395808 |
| Multiple Endocrine Neoplasia | Stem Cell Exhaustion | Generation of non-integrated induced pluripotent stem cells from a 23-year-old male with multiple endocrine neoplasia type 1 syndrome. | 28395810 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Ex vivo T-cell-depleted allogeneic stem cell transplantation for hematologic malignancies: The search for an optimum transplant T-cell dose and T-cell add-back strategy. | 28395942 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | T-cell depletion (TCD) of allogeneic stem cell transplants (SCT) can reduce graft-versus-host disease but may negatively affect transplant outcome by delaying immune recovery. | 28395942 |
| Injury of kidney | Stem Cell Exhaustion | A Time-to-Event Model for Acute Kidney Injury after Reduced-Intensity Conditioning Stem Cell Transplantation Using a Tacrolimus- and Sirolimus-based Graft-versus-Host Disease Prophylaxis. | 28396159 |
| Kidney Failure, Acute | Stem Cell Exhaustion | There is a paucity of data evaluating acute kidney injury (AKI) incidence and its relationship with the tacrolimus-sirolimus (Tac-Sir) concentrations in the setting of reduced-intensity conditioning (RIC) after allogeneic stem cell transplantation (allo-HSCT). | 28396159 |
| leukemia | Stem Cell Exhaustion | Isolated Extramedullary Relapse of Acute Leukemia after Allogeneic Stem Cell Transplantation: Different Kinetics and Better Prognosis than Systemic Relapse. | 28396161 |
| Acute leukemia, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Allogeneic stem cell transplantation (SCT) is curative treatment in patients with acute leukemia and myelodysplastic syndrome. | 28396161 |
| Malignant neoplasm of ovary, Specialty Type - cancer | Stem Cell Exhaustion | Proliferation and maturation of intratumoral blood vessels in women with malignant ovarian tumors assessed with cancer stem cells marker nestin and platelet derived growth factor PDGF-B. | 28397199 |
| Gastrointestinal Stromal Tumors | Stem Cell Exhaustion | This study ascertained the regulation of the stem cell marker CD133 and its potential applicability for prognostication of gastrointestinal stromal tumors (GISTs). | 28398518 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Sequential monitoring of lymphocyte subsets and of T-and-B cell neogenesis indexes to identify time-varying immunologic profiles in relation to graft-versus-host disease and relapse after allogeneic stem cell transplantation. | 28399164 |
| Graft-vs-Host Disease, Hematologic Neoplasms | Stem Cell Exhaustion | T and B lymphocyte subsets have been not univocally associated to Graft-versus-host disease (GVHD) and relapse of hematological malignancies after stem cell transplantation (SCT). | 28399164 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Within this retrospective single-center study, we analyzed the survival of 320 multiple myeloma (MM) patients receiving melphalan high-dose chemotherapy (HDCT) and either single (n = 286) or tandem (n = 34) autologous stem cell transplantation (ASCT) from 1996 to 2012. | 28399522 |
| Metastatic Malignant Neoplasm to the Leptomeninges | Stem Cell Exhaustion | Overexpression of syndecan-1, MUC-1, and putative stem cell markers in breast cancer leptomeningeal metastasis: a cerebrospinal fluid flow cytometry study. | 28399903 |
| Neoplasms, Childhood Breast Carcinoma | Stem Cell Exhaustion | We focused on one of the most aggressive circulating tumor cells (CTCs) which, from the primitive tumor, spreads to the central nervous system (CNS), evaluating the expression of prognostic and putative cancer stem cell markers in breast cancer (BC) leptomeningeal metastasis (LM). | 28399903 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Syndecan-1 (CD138), MUC-1 (CD227) CD45, CD34, and the putative cancer stem cell markers CD15, CD24, CD44, and CD133 surface expression were evaluated on CSF floating tumor cells. | 28399903 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | This in vivo study documents that CSF floating BC cells overexpress prognostic and putative cancer stem cell biomarkers related to tumor invasiveness, potentially representing a molecular target for circulating tumor cell detection and LM treatment monitoring, as well as a primary target for innovative treatment strategies. | 28399903 |
| Hemorrhagic cystitis | Stem Cell Exhaustion | Dynamics of BKPyV reactivation and risk of hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation. | 28401591 |
| craniofacial, Retinal defect | Stem Cell Exhaustion | The objective of this case study was to demonstrate the feasibility of a novel cell therapy treatment for localized jaw bone defects with tissue repair cells composed of a mixture of bone marrow-derived cells, including CD90+ mesenchymal stem cells and CD105+ monocytes/macrophages, and xenograft blocks, in what would be a safe and efficacious approach to the regeneration of localized craniofacial bone defects. | 28402346 |
| Multiple Myeloma | Stem Cell Exhaustion | A prospective, open-label, multicenter, observational study to evaluate the efficacy and safety of bortezomib-melphalan-prednisone as initial treatment for autologous stem cell transplantation-ineligible patients with multiple myeloma. | 28402945 |
| Thalassemia | Stem Cell Exhaustion | Of the thalassemia major patients, 5.8% had match-related hemopoietic stem cell transplantation with a success rate of 77%. | 28404539 |
| Extrapulmonary Small Cell Carcinoma | Stem Cell Exhaustion | Taken together, these results demonstrate that Lgr5 activation of Wnt/b-catenin signaling is a potential mechanism to promote the progression of ESCC and ESCC stem cell renewal, and Lgr5 may be used as a molecular target for the development of treatments for ESCC. | 28404917 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Cancer stem cells (CSCs) are defined as a rare subpopulation of undifferentiated cells with biological characteristics that include the capacity for self-renewal, differentiation into various lineages, and tumor initiation. | 28404917 |
| Extrapulmonary Small Cell Carcinoma, Squamous cell carcinoma of esophagus, Malignant Neoplasms | Stem Cell Exhaustion | To explore the mechanism of CSCs in esophageal squamous cell carcinoma (ESCC), we focused on Leucine-rich repeat containing G protein-coupled receptor 5 (Lgr5), a target gene of the Wnt signaling pathway, which has been identified as a marker of intestinal stem cells and shown to be overexpressed in several human malignancies. | 28404917 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Further analyses indicate elevated GLI1 expression is associated with an increase in tumor sphere formation, side population and cell surface markers for putative cancer stem cells. | 28404967 |
| Specialty Type - cancer | Stem Cell Exhaustion | We have evidence to support that GLI1 is critical for maintenance of putative cancer stem cells through direct regulation of ABCG2. | 28404967 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Iron overload may promote alteration of NK cells and hematopoietic stem/progenitor cells by JNK and P38 pathway in myelodysplastic syndromes. | 28405919 |
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | The objective of the study was to examine levels of intracellular iron, reactive oxygen species (ROS) and the expression of JNK and p38MAPK in NK cells and hematopoietic stem/progenitor cells (HSPCs) in MDS patients, and explore potential mechanisms by which iron overload (IOL) promotes MDS progression. | 28405919 |
| Cessation of life, Hemopoietic stem cell transplant | Stem Cell Exhaustion | The salvage chemotherapy period was defined as the first chemotherapy hospitalization after the index date to the earliest of death, loss to follow-up, last chemotherapy dose plus 30 days, or initiation of hematological stem cell transplantation (HSCT). | 28406385 |
| diabetic | Stem Cell Exhaustion | Effect of Saxagliptin on Circulating Endothelial Progenitor Cells and Endothelial Function in Newly Diagnosed Type 2 Diabetic Patients. | 28407661 |
| Antilymphocyte Serum | Stem Cell Exhaustion | Endothelial and Astrocytic Support by Human Bone Marrow Stem Cell Grafts into Symptomatic ALS Mice towards Blood-Spinal Cord Barrier Repair. | 28408761 |
| Specialty Type - cancer | Stem Cell Exhaustion | We investigated if cancer stem cells (CSCs) may have a role in pathogenesis of PTCSC. | 28411177 |
| Alzheimers Disease | Stem Cell Exhaustion | Characterization of human induced pluripotent stem cell (iPSC) line from a 72year old male patient with later onset Alzheimer's disease. | 28413002 |
| Central Diabetes Insipidus, Autosome | Stem Cell Exhaustion | Induced pluripotent stem cells derived from a patient with autosomal dominant familial neurohypophyseal diabetes insipidus caused by a variant in the AVP gene. | 28413003 |
| Parkinson Disease | Stem Cell Exhaustion | Derivation of human induced pluripotent stem cell (iPSC) line from a 79year old sporadic male Parkinson's disease patient. | 28413004 |
| Specialty Type - cancer | Stem Cell Exhaustion | Differential Ob-R mRNA expression and correlation with cancer stem cell (CSC) markers was evaluated, and correlated with severity. | 28414093 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Correlations of the expression levels with the presence of aberrant vessels were analyzed by confocal laser microscopy analysis, using FVIII as endothelial cell marker, CD133 and nestin as cancer stem cell (CSC) marker, CD20 as tumor cell marker, and Stat3. | 28415725 |
| Primary central nervous system lymphoma, Neoplasms | Stem Cell Exhaustion | Results showed that in PCNSL, putative endothelial cells lining the vessels are heterogeneous, expressing FVIII/ pStat3/CD133 (presumably originally they are vascular progenitor cells), as well as FVIII/CD20/CD133 (presumably originally they are tumor cells). | 28415725 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cluster of differentiation 44 (CD44), an indicator of cancer stem cells, can be specifically targeted by molecular probes and detected in tissues of GC in a large quantity. | 28415792 |
| Febrile Neutropenia | Stem Cell Exhaustion | Risk Adapted Management of Febrile Neutrepenia and Early Cessation of Empirical Antibiotherapy in Hematopoietic Stem Cell Transplantation Setting. | 28418340 |
| Hematological Disease | Stem Cell Exhaustion | Haematopoietic stem cell transplantation is a curative treatment option for many haematological disorders. | 28418340 |
| Communicable Diseases | Stem Cell Exhaustion | Infection following haematopoietic stem cell transplantation is one of the major causes of mortality. | 28418340 |
| Neutropenia | Stem Cell Exhaustion | To investigate the outcomes of early cessation of empirical antibiotic treatment per protocol in febrile neutropenia patients who have undergone haematopoietic stem cell transplantation at our clinic. | 28418340 |
| Febrile Neutropenia | Stem Cell Exhaustion | The present study retrospectively evaluated febrile neutropenia attacks in haematopoietic stem cell transplantation recipients during the period June 2014 - January 2015 at our haematopoietic stem cell transplantation clinic. | 28418340 |
| Childhood Non-Hodgkin Lymphoma, Malignant Neoplasms | Stem Cell Exhaustion | Long-term outcomes, secondary malignancies and stem cell collection following bendamustine in patients with previously treated non-Hodgkin lymphoma. | 28419413 |
| Hepatobiliary Disorder | Stem Cell Exhaustion | Liver stem cell therapy (SCT) has been suggested as a promising means to improve liver regeneration in advanced liver disease. | 28420441 |
| Protein secretory trypsin inhibitor | Stem Cell Exhaustion | Immunohistochemistry (Ki67, K7, and CD68), in situ hybridization (SPINK1), and global gene expression analysis were performed on liver biopsies (30 control patients and 28 patients with transarterial administration of bone marrow-derived stem cells) both at baseline and after 4 weeks of follow-up. | 28420441 |
| Protein secretory trypsin inhibitor, Inflammation, Fibrosis Assessment | Stem Cell Exhaustion | Transcriptome data revealed changes in genes linked with inflammation (CD68 and SAA), regeneration (SPINK1 and HGF), fibrosis (COL1A1), and stem cells (CD45). | 28420441 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Of the former, 12 patients underwent allogeneic hematopoietic stem cell transplantation, and 9 of these patients had graft-versus-host disease (GVHD) before undergoing esophagogastroduodenoscopy (EGD). | 28420890 |
| Kidney Failure | Stem Cell Exhaustion | We excluded pregnant women and patients with terminal renal insufficiency or past allogeneic stem cell transplantation. | 28421565 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Expression of embryonal stem cell transcription factors in breast cancer: Oct4 as an indicator for poor clinical outcome and tamoxifen resistance. | 28422735 |
| Neoplasms, Childhood Breast Carcinoma | Stem Cell Exhaustion | The relationship between the expression of these markers and clinicopathologic features of the tumors, including breast cancer stem cell phenotype and epithelial-mesenchymal transition marker expression, and their prognostic value in breast cancer, were analyzed. | 28422735 |
| Neoplasms | Stem Cell Exhaustion | The transcription factors of embryonic stem cells, such as Oct4, Sox2, Nanog, Bmi1, and Klf4, are known to be associated with stemness, epithelial-mesenchymal transition and aggressive tumor behavior. | 28422735 |
| Pleural effusion disorder, Secondary Neoplasm | Stem Cell Exhaustion | Pleural effusions have been shown to be a useful source for studying metastasis and for isolating cells with putative cancer stem cell (CSC) properties. | 28423035 |
| Specialty Type - cancer | Stem Cell Exhaustion | Patient-derived aspirates were cultured under sphere forming conditions and isolated primary cultures were further sorted for cancer stem cell subpopulations ALDH1+ and CD44+CD24-/low. | 28423035 |
| Childhood Breast Carcinoma, Pleural Effusion, Malignant | Stem Cell Exhaustion | Genetic profiling of putative breast cancer stem cells from malignant pleural effusions. | 28423035 |
| Specialty Type - cancer | Stem Cell Exhaustion | However, sequencing based molecular characterization is impeded due to insufficient sensitivity along with a high number of normal contaminating cells, which are masking genetic alterations of rare cancer (stem) cells. | 28423035 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Although PRDM14 is elevated in several cancers, it is unclear if and how PRDM14 confers stem cell-like properties and epigenetic changes to cancer cells. | 28423353 |
| Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | PRDM14 conferred stem cell-like phenotypes to cancer cells and regulated the expression of genes involved in cancer stemness, metastasis, and chemoresistance. | 28423353 |
| Specialty Type - cancer | Stem Cell Exhaustion | Our findings suggest that PRDM14 inhibition may be an effective and novel therapy for cancer stem cells. | 28423353 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | This results in a decreased proliferation of stem/progenitor cells; therefore, the Wnt signaling pathway may represent a potential target for breast cancer prevention in humans. | 28423605 |
| Glioblastoma Multiforme Pathway, Malignant Neoplasms | Stem Cell Exhaustion | Here, we investigated the NOS2 mRNA expression by reverse transcription-PCR in human glioma primary cultures at several grade of malignancy and glioma stem cell (GSC) derived neurospheres. | 28424427 |
| Glioblastoma Multiforme Pathway, Neoplasms, Aggressive course, Specialty Type - cancer | Stem Cell Exhaustion | NOS2 (inducible nitric oxide synthase) have been proposed as a component of molecular profile of several tumors, including glioma, one of the most aggressive primary brain tumor featuring local cancer stem cells responsible for enhanced resistance to therapies and for tumor recurrence. | 28424427 |
| Adenoid Cystic Carcinoma, Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Unlocking the chromatin of adenoid cystic carcinomas using HDAC inhibitors sensitize cancer stem cells to cisplatin and induces tumor senescence. | 28426972 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The total sample of 44 AML patients was analyzed on the basis of age <55 and >=55 years, sex, WBC count <50x10/9/l and >=50x10/9/l, the Hb concentration <100 g/l and >=100 g/l, PLT count <100x10/9/l and >=100x10/9/l, Karnofsky score <60% and >60%, cytogenetics, CD56 expression, morphological type and types of treatment (standard and reduced induction chemotherapy, high-dose chemotherapy/stem cell transplantation - autologous and HLA matched, related, allogeneic, together and separately). | 28428668 |
| palladium, dendritic lamellar body | Stem Cell Exhaustion | A computational analysis of SNCA 3' untranslated region to identify potential microRNA (miRNA) binding sites and quantitative real-time polymerase chain reaction (PCR) to determine their expression in isogenic induced pluripotent stem cell-derived dopaminergic and cholinergic neurons as a model of PD and DLB, respectively, were performed. | 28431219 |
| V-Series Nerve Agent VM, Specialty Type - cancer, Neoplasm Metastasis, Aggressive course, Secondary Neoplasm | Stem Cell Exhaustion | Vasculogenic mimicry (VM, blood supply formation often seen in highly aggressive tumors), Aldehyde dehydrogenase 1 (ALDH1, a biomarker of cancer stem cells), KAI1 (a suppressor gene of tumor metastasis) are all valuable factors for metastasis and prognosis in diverse human cancers. | 28431527 |
| Experimental Organism Malignant Hepatocholangiocellular Carcinoma | Stem Cell Exhaustion | Clinicopathological, radiologic, and molecular study of 23 combined hepatocellular-cholangiocarcinomas with stem cell features, cholangiolocellular type. | 28431889 |
| Experimental Organism Malignant Hepatocholangiocellular Carcinoma, Carcinoma | Stem Cell Exhaustion | According to the 2010 World Health Organization classification, this carcinoma is a combined hepatocellular-cholangiocarcinoma with stem cell features, cholangiolocellular type (CHC-SC-CLC). | 28431889 |
| Glioblastoma Multiforme Pathway, Neoplasms | Stem Cell Exhaustion | Since glioma stem cells (GSCs) have been shown to be more resistant than bulk tumor cells to anti-cancer therapies and to express high levels of these proteins, we also sought to determine if ABCG2 and XIAP have functional roles in GSCs. | 28432589 |
| Malignant Neoplasms | Stem Cell Exhaustion | Subsequent malignancies after allogeneic hematopoietic stem cell transplantation. | 28432802 |
| Post-transplant lymphoproliferative disorder, Malignant Neoplasms, Lymphoproliferative Disorders | Stem Cell Exhaustion | We evaluated 979 patients for the development of post-transplant lymphoproliferative disease (PTLD) and solid malignancies after allogeneic hematopoietic stem cell transplantations (allo-HSCT) as a late complication. | 28432802 |
| Myocardial Ischemia | Stem Cell Exhaustion | Bone marrow (BM)-derived progenitor cells are functionally impaired in patients with ischemic heart disease (IHD), thereby hampering the outcome of autologous stem cell therapy. | 28434530 |
| Myocardial Ischemia | Stem Cell Exhaustion | Accelerated replicative senescence is associated with a functional impairment of BM-derived progenitor cells in IHD and could be targeted to improve efficacy of stem cell therapy. | 28434530 |
| Myeloid Cell Differentiation, Myocardial Ischemia, Impaired T cell function | Stem Cell Exhaustion | This telomere shortening was associated with reduced myeloid differentiation capacity of BM-MNC, suggesting accelerated senescence as underlying cause for progenitor cell dysfunction in IHD. | 28434530 |
| Myocardial Ischemia | Stem Cell Exhaustion | Accelerated cellular senescence as underlying mechanism for functionally impaired bone marrow-derived progenitor cells in ischemic heart disease. | 28434530 |
| Primary amyloidosis | Stem Cell Exhaustion | Impact of Autologous Stem Cell Transplantation on the Incidence and Outcome of Oligoclonal Bands in Patients with Light-Chain Amyloidosis. | 28434927 |
| Multiple Myeloma | Stem Cell Exhaustion | The emergence of oligoclonal bands (OB) in patients with multiple myeloma achieving a complete remission (CR) after autologous stem cell transplantation (ASCT) and the use of novel agents is a well-recognized event. | 28434927 |
| Medial collateral ligament | Stem Cell Exhaustion | We examined our database of 181 consecutive MCL patients who received upfront therapy from 2005 to 2015 with either R-hyperCVAD or less intense chemotherapy (R-bendamustine and R-CHOP only) regimens to assess impact of frontline chemotherapy on collection of hematopoietic cell progenitors before autologous stem cell transplantation (ASCT). | 28434928 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Hyperfractionated Cyclophosphamide, Vincristine, Doxorubicin, and Dexamethasone Chemotherapy in Mantle Cell Lymphoma Patients Is Associated with Higher Rates of Hematopoietic Progenitor Cell Mobilization Failure despite Plerixafor Rescue. | 28434928 |
| Gigantism | Stem Cell Exhaustion | Dedifferentiation into blastomere-like cancer stem cells via formation of polyploid giant cancer cells. | 28436947 |
| Specialty Type - cancer | Stem Cell Exhaustion | Taken together, our findings demonstrate that PGCCs represent somatic equivalents of blastomeres, the most primitive cancer stem cells reported to date. | 28436947 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | High-dose thiotepa-based chemotherapy with autologous stem cell support in elderly patients with primary central nervous system lymphoma: a European retrospective study. | 28436974 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | In this retrospective multicentre study, we investigated the outcomes of elderly primary central nervous system lymphoma (PCNSL) patients (65 years) who underwent high-dose chemotherapy followed by autologous stem cell transplantation (HDT-ASCT) at 11 centres between 2003 and 2016. | 28436974 |
| Specialty Type - cancer | Stem Cell Exhaustion | Prominin-1 (Prom1) is a transmembrane glycoprotein, which is expressed in stem cell lineages, and has recently been implicated in cancer stem cell survival. | 28437526 |
| Multiple Myeloma | Stem Cell Exhaustion | Efficacy and safety of carfilzomib regimens in multiple myeloma patients relapsing after autologous stem cell transplant: ASPIRE and ENDEAVOR outcomes. | 28439109 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Autologous stem cell transplantation (ASCT) is a standard treatment for eligible multiple myeloma (MM) patients, but many patients will relapse after ASCT and require subsequent therapy. | 28439109 |
| Multiple Myeloma | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplantation (aHSCT) is the recommended standard upfront treatment for transplant eligible myeloma patients. | 28439700 |
| Multiple Myeloma | Stem Cell Exhaustion | Filgrastim-alone versus pegylated filgrastim-alone for autologous peripheral blood stem cells mobilization in newly diagnosed multiple myeloma patients. | 28439700 |
| Acute lymphocytic leukemia, BCR gene | Stem Cell Exhaustion | The efficacy of high-dose cytarabine (HDCA) plus cyclophosphamide/total-body irradiation (CY/TBI) has been proved in cord blood transplantation (CBT) for acute lymphoblastic leukaemia (ALL), but not in bone marrow or peripheral blood stem cell transplantation (BMT/PBSCT). | 28439877 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Thus, Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells, suggesting a novel TET2 loss-mediated mechanism of haematological malignancy pathogenesis. | 28440315 |
| Myocarditis, CTCAE 5.0 | Stem Cell Exhaustion | Human umbilical cord mesenchymal stem cells alleviate acute myocarditis by modulating endoplasmic reticulum stress and extracellular signal regulated 1/2-mediated apoptosis. | 28440472 |
| Myocarditis, CTCAE 5.0 | Stem Cell Exhaustion | Mesenchymal stem cells (MSCs) can alleviate myosin-induced myocarditis; however, the mechanism has not been clearly elucidated. | 28440472 |
| Lymphoma | Stem Cell Exhaustion | Methods KEYNOTE-087 ( ClinicalTrials.gov identifier, NCT02453594) was a single-arm phase II study of pembrolizumab in three cohorts of patients with rrHL, defined on the basis of lymphoma progression after (1) autologous stem cell transplantation (ASCT) and subsequent brentuximab vedotin (BV); (2) salvage chemotherapy and BV, and thus, ineligible for ASCT because of chemoresistant disease; and (3) ASCT, but without BV after transplantation. | 28441111 |
| Dental Plaque | Stem Cell Exhaustion | Endothelial progenitor cells and plaque burden in stented coronary artery segments: an optical coherence tomography study six months after elective PCI. | 28441929 |
| Neoplasms | Stem Cell Exhaustion | Recently, partitioning defective 3-like protein has been demonstrated with tumor-promoting function by disrupting tight junction, inhibiting tumor suppressor liver kinase B1, and maintaining mammary stem cells. | 28443499 |
| Sepsis | Stem Cell Exhaustion | Adipose-derived mesenchymal stem cells modulate CD14++CD16+ expression on monocytes from sepsis patients in vitro via prostaglandin E2. | 28446249 |
| Sepsis, Inflammation | Stem Cell Exhaustion | Mesenchymal stem cells (MSCs) have been shown to reduce sepsis-induced inflammation and improve survival in mouse models of sepsis. | 28446249 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease (GvHD) still belongs to the major challenges after allogeneic hematopoietic stem cell transplantation (HSCT). | 28447161 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Consecutive patients, aged 0-18 years, either diagnosed with B cell non-Hodgkin lymphoma (B-NHL) or scheduled for autologous stem cell transplantation (SCT) between April 2015 and September 2016 were included in this study. | 28447222 |
| Tears body substance | Stem Cell Exhaustion | The mesenchymal stem cell (MSC)-based tissue engineering approach has been developed to improve the treatment of rotator cuff tears. | 28448728 |
| Malignant tumor of cervix | Stem Cell Exhaustion | Hematopoietic stem cell transplant (HSCT) recipients have a higher risk of cervical cancer. | 28450182 |
| Adult Glioblastoma | Stem Cell Exhaustion | 3a-acetonyltabersonine was cytotoxic to glioblastoma cell lines (U87 and T98G) and stem cells at low concentrations. | 28452946 |
| Adult Glioblastoma, Neoplasms | Stem Cell Exhaustion | We verified 3a-acetonyltabersonine could suppress tumor cell proliferation and cause apoptosis in glioblastoma stem cells (GSCs). | 28452946 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Percentage of mesenchymal stem cells in high-grade glioma tumor samples correlates with patient survival. | 28453745 |
| Glioma | Stem Cell Exhaustion | Human mesenchymal stem cells (hMSCs) have been shown to reside as stromal cells in human gliomas as glioma-associated hMSCs (GA-hMSCs), but their biological role remains unclear. | 28453745 |
| herpesvirus 1, human, Forecast of outcome | Stem Cell Exhaustion | Association of the Emergence of Acyclovir-Resistant Herpes Simplex Virus Type 1 With Prognosis in Hematopoietic Stem Cell Transplantation Patients. | 28453848 |
| Herpes Simplex Infections | Stem Cell Exhaustion | Antiviral-resistant herpes simplex virus type 1 (HSV-1) has been recognized as an emerging clinical problem among patients undergoing hematopoietic stem cell transplantation (HSCT). | 28453848 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We retrospectively analyzed a Japanese nationwide database to elucidate the impact of abnormalities in the short arm of chromosome 17 (abnl[17p]) on the outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with acute myeloid leukemia. | 28455005 |
| MS gene | Stem Cell Exhaustion | To summarize the evidence on immunoablative therapy followed by autologous hematopoietic stem cell transplantation (aHSCT) to manage severe and treatment-refractory multiple sclerosis (MS). | 28455383 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Moreover, TrkC increased the ability to form tumor spheroids, a property associated with cancer stem cells. | 28455963 |
| Bacteremia, Clostridium difficile | Stem Cell Exhaustion | Comparison of the rates of Clostridium difficile and bacteremia after delaying fluoroquinolone prophylaxis from day 0 to day +3 post autologous stem cell transplantation. | 28456140 |
| Clostridium difficile colitis, Bacterial Infections, Immunocompromised Host | Stem Cell Exhaustion | Prophylactic fluoroquinolones are routinely administered after stem cell transplantation (SCT) to prevent bacterial infection; however, fluoroquinolones may increase the risk of Clostridium difficile infection, particularly in immunocompromised patients. | 28456140 |
| Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | NDRG1 promoted stem-like properties of LTICs in NSCLC including iPSC (induced pluripotent stem cell) factors (OCT4, SOX2, KLF4, and C-MYC), the spheres-forming ability and the tumorigenicity of NSCLC. | 28456659 |
| Childhood Breast Carcinoma, Neoplasms, Tetranitromethane | Stem Cell Exhaustion | The aim of the study was to evaluate the number of circulating endothelial progenitor cells (circulating EPCs) in the blood of patients diagnosed with breast cancer and to make an attempt at finding associations with the number of circulating EPCs and selected clinic-pathological factors; TNM and histological grading, molecular subtype of breast cancer, hormonal status, the expression of Ki-67 and the size of tumour. | 28456778 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Furthermore, our results indicated that verapamil treatment, in combination with carmustine and irradiation, rendered U87MG glioma cells and several patient-derived glioma stem cells more sensitive to therapy-induced senescence than individual or dual-combination treatments. | 28459217 |
| Hepatitis B | Stem Cell Exhaustion | Hepatitis B infection acquired after haematopioetic stem cell transplant through horizontal mode. | 28460154 |
| Ovarian failure | Stem Cell Exhaustion | Human Mesenchymal Stem Cells Partially Reverse Infertility in Chemotherapy-Induced Ovarian Failure. | 28460567 |
| Renal vascular disorder | Stem Cell Exhaustion | Autologous Mesenchymal Stem Cells Increase Cortical Perfusion in Renovascular Disease. | 28461553 |
| Angina Pectoris | Stem Cell Exhaustion | Association between echocardiographic epicardial fat thickness and circulating endothelial progenitor cell level in patients with stable angina pectoris. | 28464274 |
| Endothelial dysfunction | Stem Cell Exhaustion | Circulating endothelial progenitor cell (EPC) level represents a marker of endothelial dysfunction and vascular health. | 28464274 |
| Pancreatitis, Acute | Stem Cell Exhaustion | Endothelial progenitor cells in peripheral blood may serve as a biological marker to predict severe acute pancreatitis. | 28465644 |
| Pancreatitis | Stem Cell Exhaustion | To investigate the significance of endothelial progenitor cells (EPCs) in predicting severe acute pancreatitis (SAP). | 28465644 |
| Malignant neoplasm of stomach, Specialty Type - cancer, Atypical Glandular Cell | Stem Cell Exhaustion | A previous dose-escalation study of sulfasalazine (SSZ), an inhibitor of cystine-glutamate exchange transporter xc (-), in the variant form of CD44 (CD44v)-positive cancer stem cells (CSCs) suggested that administration of SSZ induces the reduction of CD44v-positive cells and intracellular reduced glutathione (GSH) levels in patients with advanced gastric cancer (AGC). | 28466360 |
| Pregnancy Complications, Infectious | Stem Cell Exhaustion | Functionality testing of stem cell grafts to predict infectious complications after allogeneic hematopoietic stem cell transplantation. | 28466551 |
| Hematologic Neoplasms, Metabolic Diseases, Primary immune deficiency disorder | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (HSCT) is a routine clinical procedure performed to treat patients with haematological malignancies, primary immune deficiencies or metabolic disorders. | 28466551 |
| aggressive cancer | Stem Cell Exhaustion | The transcription factor TCF7L1 is an embryonic stem cell signature gene that is upregulated in multiple aggressive cancer types, but its role in skin tumorigenesis has not yet been defined. | 28467300 |
| Malignant tumor of colon, Specialty Type - cancer | Stem Cell Exhaustion | Overexpression of IL-37 in colon cancer cell suppressed cell migration, invasion, proliferation, colony formation and cancer stem cells through suppressing b-catenin. | 28467774 |
| Specialty Type - cancer | Stem Cell Exhaustion | We performed immunohistochemistry for b-catenin, the hallmark of Wnt activation, and aldehyde dehydrogenase 1 (ALDH1), a putative cancer stem cell marker. | 28467793 |
| palladium | Stem Cell Exhaustion | Here, we show that activation of dopamine D1-class receptors elicits a large rhythmic bursting of spontaneous excitatory postsynaptic currents (sEPSCs) in midbrain neurons differentiated from induced pluripotent stem cells (iPSCs) of PD patients with parkin mutations, but not normal subjects. | 28467897 |
| Hypercholesterolemia | Stem Cell Exhaustion | Microvascular Function and Endothelial Progenitor Cells in Patients with Severe Hypercholesterolemia and the Familial Hypercholesterolemia Phenotype. | 28467991 |
| Family history, Hypercholesterolemia | Stem Cell Exhaustion | To evaluate endothelial progenitor cells (EPCs) and systemic microvascular function in patients with severe hypercholesterolemia, comparing patients with the definite familial hypercholesterolemia (FH) phenotype (DFH) or probable/possible FH phenotype (PFH). | 28467991 |
| Neutropenia, Candida (fungus) | Stem Cell Exhaustion | Patients with a history of chemotherapy or stem cell transplantation (SCT) and prolonged neutropenia are at risk for hepatic and/or splenic seeding of Candida. | 28469041 |
| Neoplasms | Stem Cell Exhaustion | HSC is not strictly limited to hematologic patients and might also occur in patients with solid tumors treated with intensive chemotherapy or stem cell transplantation. | 28469041 |
| Craniosynostosis | Stem Cell Exhaustion | Using a reversible immortalization system expressing SV40 T flanked with FRT sites, we demonstrate that primary human suture progenitor cells derived from the patent sutures of craniosynostosis patients can be efficiently immortalized. | 28470873 |
| Lupus Vulgaris | Stem Cell Exhaustion | Bone Marrow-Derived Mesenchymal Stem Cells From Patients With Systemic Lupus Erythematosus Have a Senescence-Associated Secretory Phenotype Mediated by a Mitochondrial Antiviral Signaling Protein-Interferon-b Feedback Loop. | 28471483 |
| Lupus Erythematosus, Encephalitis, St. Louis | Stem Cell Exhaustion | Bone marrow-derived mesenchymal stem cells (BM-MSCs) create a special microenvironment for hematopoiesis and immunity and display robust immunomodulatory properties that are impaired in systemic lupus erythematosus (SLE). | 28471483 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | We have generated lncRNA expression profiles from the CD34+ haematopoietic stem and progenitor cells (HSPCs) from patients with Myelodysplastic syndromes (MDS) and healthy donors. | 28472271 |
| Anaplastic Oligodendroglioma | Stem Cell Exhaustion | Multicenter phase II study of temozolomide and myeloablative chemotherapy with autologous stem cell transplant for newly diagnosed anaplastic oligodendroglioma. | 28472509 |
| Multiple Myeloma | Stem Cell Exhaustion | Hispanics have the lowest stem cell transplant utilization rate for autologous hematopoietic cell transplantation for multiple myeloma in the United States: A CIBMTR report. | 28472539 |
| Specialty Type - cancer | Stem Cell Exhaustion | By using data from the National Cancer Institute's Surveillance, Epidemiology, and End Results 18 registries, the incidence of MM was calculated, and a stem cell transplantation utilization rate (STUR) was derived. | 28472539 |
| Wiskott-Aldrich Syndrome | Stem Cell Exhaustion | Allogeneic stem cell transplant is the only curative treatment for Wiskott-Aldrich syndrome. | 28474594 |
| Dengue Fever, Viremia, Hematologic Neoplasms | Stem Cell Exhaustion | Prolonged viremia in dengue virus infection in hematopoietic stem cell transplant recipients and patients with hematological malignancies. | 28475281 |
| infectious - Entity Risk | Stem Cell Exhaustion | However, these symptoms are frequently observed in infectious and non-infectious complications of hematopoietic stem cell transplant recipients and oncohematological patients. | 28475281 |
| Acute GVH disease, Gastrointestinal tract structure, Therapy-Related Acute Myeloid Leukemia | Stem Cell Exhaustion | We report the case of a 35-year-old man who underwent allogenic stem cell transplantation for a therapy-associated acute myeloid leukemia and developed an acute GvHD with involvement of skin and gastrointestinal tract. | 28475513 |
| Extrapulmonary Small Cell Carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Overexpression of CPA4 was closely associated with the putative cancer stem cell marker ALDH1A1 and might be used as an independent prognostic factor in ESCC. | 28475748 |
| Specialty Type - cancer | Stem Cell Exhaustion | Nucleostemin (NS)/GNL3 protein has been recently documented to be a nucleolar protein that was abundantly expressed in stem cells and cancer cells. | 28476378 |
| Lymphoma | Stem Cell Exhaustion | Phase I/II Study of Intravenous Plerixafor Added to a Mobilization Regimen of Granulocyte Colony-Stimulating Factor in Lymphoma Patients Undergoing Autologous Stem Cell Collection. | 28476490 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Plerixafor, given subcutaneously with granulocyte colony-stimulating factor (G-CSF), improves autologous stem cell collection in patients with lymphoma and multiple myeloma. | 28476490 |
| Lymphoma | Stem Cell Exhaustion | plerixafor is well tolerated and effective when added to G-CSF for the mobilization of stem cells from patients with lymphoma, with mobilization kinetics and stem cell collections that compare favorably with subcutaneous dosing. | 28476490 |
| Osteoporotic Fractures | Stem Cell Exhaustion | Autophagy promotes osteogenic differentiation of human bone marrow mesenchymal stem cell derived from osteoporotic vertebrae. | 28476617 |
| Osteoporosis, Senile | Stem Cell Exhaustion | Reduced bone formation caused by senescence is a main cause for senile osteoporosis, however, how to improve the osteogenic differentiation of osteoporotic bone marrow mesenchymal stem cells (BMSCs) remains a challenge. | 28476617 |
| Specialty Type - cancer | Stem Cell Exhaustion | The Clinical Significance of Cancer Stem Cell Markers ALDH1A1 and CD133 in Lung Adenocarcinoma. | 28476825 |
| Specialty Type - cancer | Stem Cell Exhaustion | Aldehyde dehydrogenase-1A1 (ALDH1A1) and CD133 have been identified as markers of cancer stem cells (CSCs). | 28476825 |
| Communicable Diseases | Stem Cell Exhaustion | Dental status does not predict infection during stem cell transplantation: a single-center survey. | 28481351 |
| Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Biological markers for risk stratification of chronic GvHD (cGvHD) could improve the care of patients undergoing allogeneic hematopoietic stem cell transplantation. | 28481353 |
| Degenerative polyarthritis | Stem Cell Exhaustion | A consistent and potentially exploitable response during chondrogenesis of mesenchymal stem cells from osteoarthritis patients to the protein encoded by the susceptibility gene GDF5. | 28481944 |
| HD Term Type, FAP protein, human | Stem Cell Exhaustion | HD-derived CD14 + monocytes and induced pluripotent stem cell-derived myeloid lineage cells from a HD and FAP patient dose-dependently produced IL-6 under mutated and aggregated TTR conditions, compared with wild-type TTR. | 28484271 |
| Aggressive Adult Non-Hodgkin Lymphoma | Stem Cell Exhaustion | A randomized phase II study of standard-dose versus high-dose rituximab with BEAM in autologous stem cell transplantation for relapsed aggressive B-cell non-hodgkin lymphomas: long term results. | 28485023 |
| Aggressive Adult Non-Hodgkin Lymphoma | Stem Cell Exhaustion | High-dose rituximab (HD-R) combined with carmustine, cytarabine, etoposide and melphalan (BEAM) and autologous stem cell transplant (ASCT) was effective and tolerable in a single-arm prospective study of relapsed aggressive B-cell non-Hodgkin lymphoma (R-NHL). | 28485023 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Myelodysplastic syndrome is characterized by stem-cell-derived clonal myelopoiesis with an alteration in proliferation and differentiation. | 28488979 |
| Malignant Neoplasms | Stem Cell Exhaustion | CPAM type 2-derived mesenchymal stem cells: Malignancy risk study in a 14-month-old boy. | 28493304 |
| Neoplasms | Stem Cell Exhaustion | Interactions between the tumor, immune, and mesenchymal stromal/stem cells (MSCs) have been recognized as crucial for understanding tumorigenesis. | 28493304 |
| Prostate carcinoma | Stem Cell Exhaustion | Mesenchymal Stem Cells (MSCs) have been identified in prostate cancer, raising the critical question of their physical and temporal source. | 28493842 |
| Prostate carcinoma | Stem Cell Exhaustion | In contrast to lineage-restricted Mesenchymal Progenitor Cells (MPCs) found in normal prostate tissue, MSCs with tri-lineage differentiation potential (adipogenesis, osteogenesis, and chondrogenesis) are identified in prostate tissue from a subset of men with prostate cancer, consistent with an influx of more stem-like progenitors (i.e. | 28493842 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | In patients with chronic lymphocytic leukemia (CLL), persistence of disease after allogeneic stem cell transplantation (alloSCT) can result in poor outcomes. | 28495642 |
| Crohn Disease | Stem Cell Exhaustion | Autologous stem-cell transplantation in treatment-refractory Crohn's disease: an analysis of pooled data from the ASTIC trial. | 28497755 |
| Gastrointestinal inflammation, Crohn Disease | Stem Cell Exhaustion | The randomised controlled ASTIC trial showed no benefit of mobilisation and autologous haematopoietic stem-cell transplantation (HSCT) compared with mobilisation followed by conventional therapy using a stringent primary endpoint (steroid-free clinical remission for 3 months with no endoscopic or radiological evidence of intestinal inflammation) in patients with treatment-refractory Crohn's disease. | 28497755 |
| Endometrial Carcinoma | Stem Cell Exhaustion | Increased Endothelial Progenitor Cell Number in Early Stage of Endometrial Cancer. | 28498245 |
| Endometrial Carcinoma | Stem Cell Exhaustion | Endothelial progenitor cell numbers (CD34, VEGFR2/KDR) in the peripheral blood of women with endometrial carcinoma were significantly augmented as compared with those of control healthy women and CEC numbers (CD31, CD45) were similar in both groups. | 28498245 |
| Tissue damage | Stem Cell Exhaustion | With this background, the aim of this study is firstly to examine the impact of a selective centrifugation on existing adipose stem cells (ASCs) in terms of stemness profile maintenance and, secondly, to investigate the effect of restoring volume in reconstruction on patients affected by soft tissue damage. | 28498335 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Allogeneic Hematopoietic Stem Cell Transplantation for Adolescents and Young Adults with Acute Myeloid Leukemia. | 28501543 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Few reports have focused on adolescent and young adult (AYA) patients with acute myeloid leukemia (AML) treated with hematopoietic stem cell transplantation (HSCT). | 28501543 |
| Encephalitis, Hyponatremia | Stem Cell Exhaustion | Hyponatremia associated with human herpesvirus-6 (HHV-6) encephalitis after allogeneic hematopoietic stem cell transplantation: A presentation different from HHV-6 myelitis. | 28501929 |
| Encephalitis, Myelitis | Stem Cell Exhaustion | Human herpesvirus-6 (HHV-6) encephalitis and myelitis following allogeneic hematopoietic stem cell transplantation (HSCT) is frequently life-threatening. | 28501929 |
| Antiphospholipid Syndrome, Mucosa-Associated Lymphoid Tissue Lymphoma | Stem Cell Exhaustion | Successful Treatment of Catastrophic Antiphospholipid Antibody Syndrome Associated with MALT Lymphoma by Autologous Hematopoietic Stem Cell Transplantation. | 28502938 |
| Lymphoma | Stem Cell Exhaustion | One month later, the CAPS and lymphoma relapsed, and the patient underwent autologous hematopoietic stem cell transplantation. | 28502938 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We studied the effect of IA on mortality in 167 consecutive patients starting with remission-induction therapy for AML or of whom most patients continued to haematopoietic stem cell transplantation (HSCT). | 28504663 |
| Specialty Type - cancer | Stem Cell Exhaustion | Recent advances in single-cell transcriptomics are ideally placed to unravel intratumoral heterogeneity and selective resistance of cancer stem cell (SC) subpopulations to molecularly targeted cancer therapies. | 28504724 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia. | 28504724 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | Immunohistochemical analysis of a panel of primitive phenotypic markers, including embryonic stem cell markers (OCT4, NANOG, SALL4, CLDN6, and LIN28) and known oncofetal proteins (AFP and GPC3), was performed using tissue microarray on 386 gastric cancers. | 28505005 |
| SLC26A3 wt Allele, Specialty Type - cancer, Chronic lung disease, Hematologic Neoplasms, HIV Infections | Stem Cell Exhaustion | The study population included 116 patients, 37.9% of whom had haematological malignancy or underwent haematological stem cell transplantation (HSCT), 22.4% had HIV infection, 16.4% had chronic lung diseases (CLD), 7.8% had a solid cancer, and 3.4% underwent a solid organ transplant (SOT). | 28505159 |
| Graft-vs-Host Disease, Chronic graft-versus-host disease, Autoimmune Disorder, CTCAE | Stem Cell Exhaustion | Chronic graft-versus-host disease (GVHD) appears several months following allogenic hematopoietic stem cell transplantation (HSCT) and is clinically analogous to autoimmune disorder. | 28506261 |
| Carcinoma, Specialty Type - cancer, Neoplasms, Secondary Neoplasm, Carcinogenesis | Stem Cell Exhaustion | As a cancer stem cell marker, CD44 variant 6 (CD44v6) has been implicated in carcinogenesis, tumor progression, and metastasis in a variety of human carcinomas. | 28507278 |
| herpesvirus 3, human | Stem Cell Exhaustion | Duration of Antiviral Prophylaxis and Risk of Herpes Zoster among Patients Receiving Autologous Hematopoietic Stem Cell Transplants: A Retrospective, Observational Study. | 28508307 |
| herpesvirus 3, human | Stem Cell Exhaustion | There are no real-world data on antiviral prophylaxis (AP) duration and risk of herpes zoster (HZ) given AP duration in patients receiving autologous hematopoietic stem cell transplants (auto-HSCT). | 28508307 |
| HLA Mismatch, Hematologic Neoplasms | Stem Cell Exhaustion | No effect of HLA-C mismatch after allogeneic hematopoietic stem cell transplantation with unrelated donors and T-cell depletion in patients with hematological malignancies. | 28510343 |
| HLA Mismatch | Stem Cell Exhaustion | HLA-C mismatch in unrelated donor's hematopoietic stem cell transplantation (HSCT) has been associated with poor patient outcome. | 28510343 |
| Rheumatoid Arthritis, Degenerative polyarthritis | Stem Cell Exhaustion | Yields and chondrogenic potential of primary synovial mesenchymal stem cells are comparable between rheumatoid arthritis and osteoarthritis patients. | 28511664 |
| Chromothripsis | Stem Cell Exhaustion | We also found a novel fusion involving USP9X-ERAS formed by chromothripsis and leading to high expression of ERAS, a constitutively active RAS protein normally expressed only in embryonic stem cells. | 28512242 |
| Hodgkin Disease | Stem Cell Exhaustion | Outcomes of patients with relapsed/refractory Hodgkin lymphoma progressing after autologous stem cell transplant in the current era of novel therapeutics: A retrospective analysis. | 28512788 |
| Hodgkin Disease | Stem Cell Exhaustion | Patients with relapsed/refractory Hodgkin lymphoma (RR-HL) who progress or relapse following autologous stem cell transplantation (ASCT) have historically had a poor prognosis. | 28512788 |
| Multiple Myeloma | Stem Cell Exhaustion | Outcome of autologous hematopoietic stem cell transplantation in refractory multiple myeloma. | 28513828 |
| Multiple Myeloma | Stem Cell Exhaustion | Patients with refractory myeloma who underwent first autologous hematopoietic stem cell transplantation (auto-HCT) between March 2000 and October 2015 were retrospectively analyzed. | 28513828 |
| Neoplasms | Stem Cell Exhaustion | We established the neuroendocrine tumor sphere cell line ANI-27S, which displayed stable exponential growth, virtually unlimited expansion in vitro, and expression of stem-cell markers such as CD133, nestin, Sox2, and aldehyde dehydrogenase. | 28516286 |
| Liver Neuroendocrine Tumor | Stem Cell Exhaustion | For the first time, we demonstrated the presence of a sphere-forming, stem cell-like population in brain metastases from a primary neuroendocrine tumor. | 28516286 |
| Neuroendocrine Tumors, Specialty Type - cancer | Stem Cell Exhaustion | Neuroendocrine tumors are rare, and little is known about the existence of cancer stem cells in this disease. | 28516286 |
| leukemia | Stem Cell Exhaustion | Disulfiram/copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-kB and Nrf2. | 28518151 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Leukemia stem cells (LSCs) is the major cause of the recurrence of AML even after aggressive treatment making, promoting development of LSC-targeted agents is an urgent clinical need. | 28518151 |
| Hematologic Neoplasms, Neoplasms, Specialty Type - cancer, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Although the antitumor activity of disulfiram (DS), an approved anti-alcoholism drug, has been demonstrated in multiple types of tumors including hematological malignancies such as AML, it remains unknown whether this agent would also be able to target cancer stem cells like LSCs. | 28518151 |
| Pseudomonas aeruginosa | Stem Cell Exhaustion | Control of Multidrug-Resistant Pseudomonas aeruginosa in Allogeneic Hematopoietic Stem Cell Transplant Recipients by a Novel Bundle Including Remodeling of Sanitary and Water Supply Systems. | 28520856 |
| Pseudomonas aeruginosa, Infection | Stem Cell Exhaustion | Infections by multidrug-resistant Pseudomonas aeruginosa (MDRPa) are an important cause of morbidity and mortality in patients after allogeneic hematopoietic stem cell transplantation (HSCT). | 28520856 |
| Meibomian gland dysfunction | Stem Cell Exhaustion | Evaluation of endocrine and metabolic dysfunctions after hematopoietic stem cell transplantation in children: a study from Turkey. | 28525352 |
| Complication Aspects | Stem Cell Exhaustion | The objective of the study was to evaluate endocrine and metabolic complications after hematopoietic stem cell transplantation (HSCT) in children. | 28525352 |
| Multiple Myeloma | Stem Cell Exhaustion | Efficacy and safety of plerixafor for the mobilization/collection of peripheral hematopoietic stem cells for autologous transplantation in Japanese patients with multiple myeloma. | 28527129 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | To evaluate the efficacy and safety of plerixafor for the mobilization/collection of peripheral hematopoietic stem cells (HSCs) for autologous transplantation in Japanese patients with multiple myeloma (MM). | 28527129 |
| Specialty Type - cancer | Stem Cell Exhaustion | Between September 2011 and February 2014, 126 pediatric cancer patients were admitted to our center for chemotherapy and/or hematopoietic stem cell transplantation and were included in this study. | 28527651 |
| Comorbidity, Relapsing course | Stem Cell Exhaustion | Long-Term Follow-Up and Impact of Comorbidity before Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Relapsed or Refractory Acute Myeloid Leukemia-Lessons Learned from the Prospective BRIDGE Trial. | 28527985 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | In patients with relapsed or refractory (r/r) acute myeloid leukemia (AML), allogeneic hematopoietic stem cell transplantation (HSCT) is considered to be the only treatment providing long-term disease control. | 28527985 |
| Colonization | Stem Cell Exhaustion | Clinical Impact of Colonization with Multidrug-Resistant Organisms on Outcome after Autologous Stem Cell Transplantation: A Retrospective Single-Center Study. | 28528711 |
| Multi-Drug Resistant Organism | Stem Cell Exhaustion | To determine the impact of colonization with MDRO on overall survival, we retrospectively analyzed data from patients undergoing autologous hematopoietic stem cell transplantation at our institution. | 28528711 |
| Hematologic | Stem Cell Exhaustion | 139 haematological cancer patients who underwent a stem cell transplantation completed a longitudinal questionnaire according to 3 phases of the treatment: short-term (pre-transplant), medium-term (1st year post-transplant) and long-term (2nd-6th year post-transplant). | 28529098 |
| Specialty Type - cancer | Stem Cell Exhaustion | Tumour-initiating cells, or cancer stem cells (CSCs), possess stem-cell-like properties observed in normal adult tissue stem cells. | 28530657 |
| Lymphoma, Follicular, Lymphoma | Stem Cell Exhaustion | Radioimmunotherapy-augmented BEAM chemotherapy vs BEAM alone as the high-dose regimen for autologous stem cell transplantation (ASCT) in relapsed follicular lymphoma (FL): a retrospective study of the EBMT Lymphoma Working Party. | 28530668 |
| Lymphoma, Follicular, Failure | Stem Cell Exhaustion | Relapse remains the most common cause of treatment failure in patients receiving autologous stem cell transplantation (ASCT) for follicular lymphoma (FL). | 28530668 |
| Hematologic Neoplasms | Stem Cell Exhaustion | High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is frequently performed in patients with hematologic malignancies. | 28533058 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Autologous Stem Cell Transplantation for Follicular Lymphoma: Favorable Long-Term Survival Irrespective of Pretransplantation Rituximab Exposure. | 28533060 |
| Lymphoma, Follicular | Stem Cell Exhaustion | High-dose chemotherapy supported by autologous stem cell transplantation (HDT/ASCT) has contributed to modify the natural history of follicular lymphoma (FL); however, an overall survival (OS) benefit has been demonstrated at relapse only after a rituximab-free chemotherapy regimen. | 28533060 |
| Huntingtons Disease Pathway | Stem Cell Exhaustion | KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients. | 28533375 |
| Specialty Type - cancer, Squamous cell carcinoma of esophagus | Stem Cell Exhaustion | Enhanced cancer stem cell properties of a mitotically quiescent subpopulation of p75NTR-positive cells in esophageal squamous cell carcinoma. | 28534989 |
| Specialty Type - cancer | Stem Cell Exhaustion | Mitotically quiescent cancer stem cells (CSCs) possess higher malignant potential than other CSCs, indicating their higher contribution to therapeutic resistance than that of other CSCs. | 28534989 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Autologous stem cell transplantation (ASCT) in patients with mantle cell lymphoma: a retrospective study of the Spanish lymphoma group (GELTAMO). | 28536895 |
| Left ventricular aneurysm, Perforation (observation) | Stem Cell Exhaustion | As the field of stem cell therapy evolves and the use of this technique increases, operators must be aware that the presence of an LV aneurysm may increase the risk of perforation during a NOGA mapping procedure. | 28539211 |
| Left ventricular aneurysm, Perforation (observation) | Stem Cell Exhaustion | We present the case of a woman who developed a perforation at the site of an LV aneurysm during NOGA mapping prior to the transendocardial injection of stem cells, as part of a multicenter clinical trial. | 28539211 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Purpose: Chemokine receptor 1 (CXCR1) is recognized as an actionable receptor selectively expressed by breast cancer stem cells (BCSCs). | 28539464 |
| leukemia, Myeloid-Lymphoid Leukemia Protein | Stem Cell Exhaustion | Because of the poor prognosis linked to these leukemias, the patient benefited from chemotherapy targeting both myeloid and lymphoid components, followed by allogeneic hematopoietic stem cell transplantation. | 28540857 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Clinical impact of pretransplant use of multiple tyrosine kinase inhibitors on the outcome of allogeneic hematopoietic stem cell transplantation for chronic myelogenous leukemia. | 28543934 |
| Failure | Stem Cell Exhaustion | Therefore, allogeneic hematopoietic stem cell transplantation (allo-HSCT) is considered only for patients with disease progression or for patients after treatment failure with multiple TKIs. | 28543934 |
| Disease, Malignant Peripheral Nerve Sheath Tumor, Primary Myelofibrosis, leukemia | Stem Cell Exhaustion | BCR-ABL1-negative myeloproliferative neoplasms (MPNs) are clonal stem cell disorders defined by proliferation of one or more myeloid lineages, and carry an increased risk of vascular events and progression to myelofibrosis and leukemia. | 28543980 |
| Inflammation, Hypertensive (finding), Vascular System Injuries | Stem Cell Exhaustion | Kallistatin, an endogenous protein, protects against vascular injury by inhibiting oxidative stress and inflammation in hypertensive rats and enhancing the mobility and function of endothelial progenitor cells (EPCs). | 28544111 |
| Viral respiratory infection | Stem Cell Exhaustion | Here we report the applicability of a protocol based on clinical conditions and risk factors (RFs) for managing 35 allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients who developed a total of 52 episodes of respiratory viral infections (RVIs) caused by respiratory syncytial virus (RSV; n=19), human parainfluenza virus (HPIV; n=29), or both (n=4) over a 2-year study period. | 28544152 |
| Specialty Type - cancer | Stem Cell Exhaustion | Emergence of CD26+ Cancer Stem Cells with Metastatic Properties in Colorectal Carcinogenesis. | 28545226 |
| Colorectal Carcinoma, Secondary Neoplasm | Stem Cell Exhaustion | A subpopulation of CD26+ colorectal cancer stem cells are known to be implicated in metastasis. | 28545226 |
| Specialty Type - cancer, Neoplasms, Carcinogenesis | Stem Cell Exhaustion | We hypothesized that this subpopulation of cancer stem cells arises in the late stage of carcinogenesis from the bulk of tumor daughter cells which are CD26-. | 28545226 |
| Colorectal Carcinoma, Neoplasms | Stem Cell Exhaustion | These findings shed light to the origin of colorectal cancer stem cells with metastatic properties, which has an implication on conventional treatments by surgery or adjuvant chemotherapy for tumor debulking. | 28545226 |
| Neoplasms, Central neuroblastoma | Stem Cell Exhaustion | Neuroblastoma is the most common solid tumor in childhood and develops from undifferentiated progenitor cells of the sympathetic nervous system. | 28545464 |
| Specialty Type - cancer, Carcinoma, Ovarian Epithelial, Neoplasms | Stem Cell Exhaustion | The existence of cancer stem cells (CSCs) within a tumor bulk has been demonstrated for many solid tumors including epithelial ovarian carcinoma (EOC). | 28545541 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease (GvHD) is a major complication of allogeneic stem cell transplantation. | 28547857 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | Haploidentical allogeneic hematopoietic stem cell transplantation compared to matched unrelated transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. | 28549237 |
| B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1, BCR gene | Stem Cell Exhaustion | To investigate the effect of haploidentical allogeneic hematopoietic stem cell transplantation (Haplo-HCT) in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL), the outcome of 58 patients with Ph+ ALL who received Haplo-HCT (n=42) or matched unrelated donor transplantation (MUD-HCT) (n=16) during the same period were analyzed retrospectively. | 28549237 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease (GVHD) hampers the utility of allogeneic hematopoietic stem cell transplantation (AHSCT). | 28549771 |
| Fever | Stem Cell Exhaustion | HHV-6 reactivation as a cause of fever in autologous hematopoietic stem cell transplant recipients. | 28551368 |
| Lymphoma | Stem Cell Exhaustion | We report the biological and clinical impacts possibly associated with HHV-6 reactivation in autologous hematopoietic stem cell transplant (AHSCT) recipients after intensive chemotherapy regimen for lymphoma. | 28551368 |
| Neoplasms | Stem Cell Exhaustion | Stem cell marker MELK was noted to stain both the neoplastic ependymal and ganglionic components, possibly suggesting a stem cell/progenitor origin for the tumor with subsequent divergent differentiation. | 28554236 |
| Photoreceptor degeneration | Stem Cell Exhaustion | Pluripotent stem cells and their utility in treating photoreceptor degenerations. | 28554397 |
| retinal development | Stem Cell Exhaustion | Driven in large part by the requirement for renewable cell sources, stem cells have emerged not only as a promising source of replacement photoreceptors but also to provide in vitro systems with which to study retinal development and disease processes and to test therapeutic agents. | 28554397 |
| Diabetes | Stem Cell Exhaustion | Electrical Muscle Stimulation Induces an Increase of VEGFR2 on Circulating Hematopoietic Stem Cells in Patients With Diabetes. | 28554530 |
| physiopathological, Hyperglycemia, Inflammation | Stem Cell Exhaustion | The inflammation and oxidative stress of bone marrow-derived proangiogenic cells (PACs), also named endothelial progenitor cells, triggered by hyperglycemia contributes significantly to vascular dysfunction. | 28555162 |
| Multiple Myeloma | Stem Cell Exhaustion | Poor peripheral blood stem cell mobilization affects long-term outcomes in multiple myeloma patients undergoing autologous stem cell transplantation. | 28556233 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Peripheral blood stem cell (PBSC) mobilization is routinely undertaken prior to autologous stem cell transplantation (ASCT) in patients with multiple myeloma (MM). | 28556233 |
| leukemia, Acute lymphocytic leukemia | Stem Cell Exhaustion | Unmanipulated haploidentical stem cell transplantation in adults with acute lymphoblastic leukemia: a study on behalf of the Acute Leukemia Working Party of the EBMT. | 28558762 |
| Acute lymphocytic leukemia, BCR gene | Stem Cell Exhaustion | Allogenic hematopoietic stem cell transplantation (allo-SCT) is the most effective post-remission treatment for adults with high-risk acute lymphoblastic leukemia (ALL). | 28558762 |
| Glioblastoma Multiforme Pathway, Adult Glioblastoma | Stem Cell Exhaustion | Stemness Marker Detection in the Periphery of Glioblastoma and Ability of Glioblastoma to Generate Glioma Stem Cells: Clinical Correlations. | 28559081 |
| Glioblastoma Multiforme Pathway, Glioblastoma | Stem Cell Exhaustion | Recent studies suggested glioma stem cells (GSCs) are key contributors to therapeutic resistance of glioblastoma multiforme (GBM) and are responsible for GBM recurrence. | 28559081 |
| Hemorrhagic cystitis | Stem Cell Exhaustion | Viral-induced Hemorrhagic Cystitis After Allogeneic Hematopoietic Stem Cell Transplant. | 28559150 |
| CLTC gene, Hemorrhagic cystitis | Stem Cell Exhaustion | Hemorrhagic cystitis (HC) is a well-recognized problem that is regularly observed after hematopoietic stem cell transplantation (HSCT). | 28559150 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | High-dose chemotherapy with autologous haematopoietic stem cell support for relapsed or refractory primary CNS lymphoma: a prospective multicentre trial by the German Cooperative PCNSL study group. | 28559537 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | To investigate safety and efficacy of high-dose chemotherapy followed by autologous stem cell transplantation (HCT-ASCT) in relapsed/refractory (r/r) primary central nervous system lymphoma (PCNSL), we conducted a single-arm multicentre study for immunocompetent patients (<66 years) with PCNSL failing high-dose methotrexate)-based chemotherapy. | 28559537 |
| Hepatic Veno-Occlusive Disease, Spondylo-ocular syndrome | Stem Cell Exhaustion | Sinusoidal obstruction syndrome (SOS) is a life-threatening complication of hematopoietic stem cell transplantation (HSCT) associated with significant morbidity and mortality. | 28562132 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | For relapsed or elderly MDS and AML patients ineligible for hematopoietic stem cell transplantation, epigenetic therapies, including DNA methyltransferase inhibitors and histone deacetylase inhibitors, have been utilized as palliative therapy, offering a well-tolerated approach to disease stabilization, prolonged survival, and quality of life. | 28562519 |
| Bone Marrow Diseases, Neoplasms | Stem Cell Exhaustion | Both patients were ineligible for hematopoietic stem cell transplantation due to concurrent solid tumor relapse, but were treated with the epigenetic combination therapy, decitabine and vorinostat, and achieved stabilization of marrow disease, outpatient palliation, and family-reported reasonable quality of life. | 28562519 |
| Liver carcinoma, Hepatitis B | Stem Cell Exhaustion | Hepatitis B virus X protein induces hepatic stem cell-like features in hepatocellular carcinoma by activating KDM5B. | 28566884 |
| Liver carcinoma, Hollings Cancer Center, Hepatitis B | Stem Cell Exhaustion | To determine the role of hepatitis B virus X protein (HBx), HBx in regulating hepatic progenitor cell (HPC)-like features in hepatocellular carcinoma (HCC) and the underlying molecular mechanisms. | 28566884 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | The aim of this study was to evaluate whether blood transfusions affect overall survival (OS) and progression-free survival (PFS) in newly diagnosed multiple myeloma (MM) patients without hematopoietic stem cell transplantation. | 28567420 |
| Cartilage | Stem Cell Exhaustion | In vitro cultured autologous mesenchymal stem cells (MSCs) within passage 5 have been approved for clinical application in stem cell-based treatment of cartilage defects. | 28569773 |
| Cartilage | Stem Cell Exhaustion | In vitro expansion impaired the stemness of early passage mesenchymal stem cells for treatment of cartilage defects. | 28569773 |
| teratologic | Stem Cell Exhaustion | This result indicates that telomerase and chromosome anomalies might originate from expansion, leading to impaired stemness and pluripotency of stem cells. | 28569773 |
| Anemia, Sickle Cell, Toxic effect | Stem Cell Exhaustion | Reduced toxicity, myeloablative HLA-haploidentical hematopoietic stem cell transplantation with post-transplantation cyclophosphamide for sickle cell disease. | 28573314 |
| Anemia, Sickle Cell, Renal carnitine transport defect | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (HSCT) offers the possibility of cure for sickle cell disease (SCD) patients. | 28573314 |
| Failure | Stem Cell Exhaustion | Failure to achieve CR with induction therapy, and age >65 years are associated with poor outcomes in MS. Allogeneic stem-cell transplant in first remission appears to be the most effective modality for achieving long-term remissions. | 28574302 |
| Aleukemic leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Despite the heterogeneity of acute myeloid leukemia (AML), overexpression of the interleukin-3 receptor-a (CD123) on both the more differentiated leukemic blast and leukemic stem cells (LSCs) provides a therapeutic target for antibody treatment. | 28574487 |
| Squamous cell carcinoma | Stem Cell Exhaustion | Chemokine (CC motif) ligand 18 upregulates Slug expression to promote stem-cell like features by activating the mammalian target of rapamycin pathway in oral squamous cell carcinoma. | 28574664 |
| Specialty Type - cancer | Stem Cell Exhaustion | In conclusion, our data suggested that CCL18 upregulated Slug expression to promote EMT and stem cell-like features by activating the mTOR pathway in oral cancer. | 28574664 |
| Specialty Type - cancer, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | The cancer stem cell (CSC) hypothesis considers CSCs to be the main culprits in driving tumor initiation, metastasis, and resistance to conventional therapy. | 28574829 |
| Malignant tumor of colon | Stem Cell Exhaustion | Previous evidence has shown that high-calorie diet (HCD) enhances colonic stem cell numbers and expansion of the proliferative zone, an important biomarker for colon cancer. | 28576788 |
| Zygomycosis, Cunninghamella bertholletiae, Communicable Diseases | Stem Cell Exhaustion | Infection caused by Cunninghamella bertholletiae carries one of the highest mortality rates among mucormycosis, and there are no reported cases that survived from the infection in allogeneic hematopoietic stem cell transplantation recipients occurring before neutrophil engraftment. | 28577122 |
| Osteoporosis | Stem Cell Exhaustion | A biophysical approach to quantify skeletal stem cells trans-differentiation as a model for the study of osteoporosis. | 28578832 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | When should preemptive antiviral therapy for active CMV infection be withdrawn from allogeneic stem cell transplant recipients? | 28581458 |
| Leukemia, Myelocytic, Acute, NPM1 wt Allele | Stem Cell Exhaustion | Dynamics of molecular response in AML patients with NPM1 and FLT3 mutations undergoing allogeneic stem cell transplant. | 28581462 |
| Neurotoxicity Syndromes | Stem Cell Exhaustion | Attempts to improve efficacy and reduce neurotoxicity of consolidation therapy have included thiotepa-based high-dose chemotherapy and autologous stem cell transplant (HDC-ASCT). | 28581466 |
| Neoplasms | Stem Cell Exhaustion | Administration of high-dose chemotherapy with stem cell support in patients 40 years of age or older with advanced germ cell tumours: a retrospective study from the European Society for Blood and Marrow Transplantation database. | 28581469 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Allogeneic stem cell transplantation (allo-SCT) with or without donor lymphocyte infusions (DLI) is the only curative option for several hematological malignancies. | 28581468 |
| Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Chronic GvHD (cGvHD) is the leading cause of late non-relapse mortality (NRM) and morbidity after allogeneic hematopoietic stem cell transplant (AHSCT). | 28581472 |
| Hodgkin Disease | Stem Cell Exhaustion | Brentuximab vedotin consolidation post-autologous stem cell transplant in Hodgkin lymphoma patients at risk of residual disease: number needed to treat. | 28583027 |
| NNT gene | Stem Cell Exhaustion | The number needed to treat (NNT) with brentuximab vedotin consolidation therapy post-autologous stem cell transplant (ASCT) versus placebo in the phase 3 AETHERA trial to avoid one additional event of disease progression/death was evaluated. | 28583027 |
| Medial collateral ligament, Mantle cell lymphoma | Stem Cell Exhaustion | The pivotal LYM-3002 study compared frontline rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) with bortezomib, rituximab, cyclophosphamide, doxorubicin and prednisone (VR-CAP) in newly diagnosed mantle cell lymphoma (MCL) patients for whom stem cell transplantation was not an option. | 28583031 |
| Lymphoma, Non-Hodgkin, Multiple Myeloma | Stem Cell Exhaustion | Patients who underwent hematopoietic stem cell transplantation for multiple myeloma had a significantly higher 5-year mortality rate (100%) compared with patients who had an underlying diagnosis of non-Hodgkin's lymphoma (0%) (P=.008). | 28585995 |
| Perianal abscess | Stem Cell Exhaustion | Perianal abscess developed in various phases of treatment and in the stem cell transplantation period. | 28586772 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Extracorporeal photopheresis for GVHD prophylaxis after reduced intensity conditioning allogeneic hematopoietic stem cell transplantation: a prospective multicenter phase 2 study. | 28587506 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | The best approach for allogeneic haematopoietic stem cell transplantations (alloHCT) in patients with chronic lymphocytic leukaemia (CLL) is unknown. | 28589551 |
| Opportunistic Infections | Stem Cell Exhaustion | Are the Polyomaviruses BK and JC Associated with Opportunistic Infections, Graft-versus-Host Disease, or Worse Outcomes in Adult Patients Receiving Their First Allogeneic Stem Cell Transplantation with Low-Dose Alemtuzumab? | 28591758 |
| Graft-vs-Host Disease, Opportunistic Infections | Stem Cell Exhaustion | The association of polyomaviruses BK and JC with other opportunistic infections and graft-versus-host disease (GvHD) in allogeneic stem cell transplantation is controversially discussed. | 28591758 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplantation for acute myeloid leukemia - single center experience. | 28592126 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We aimed to determine the effect of autologous hematopoietic stem cell transplantation (auto-HSCT) on acute myeloid leukemia (AML) patients as a valid alternative therapeutic option for patients without HLA-compatible donor. | 28592126 |
| Malignant neoplasm of stomach, Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | Predictive value for lymph node metastasis of epithelial-mesenchymal transition and cancer stem cell marker expression in early gastric cancer. | 28595915 |
| Malignant neoplasm of stomach, Secondary Neoplasm | Stem Cell Exhaustion | In the present study, the significance of epithelial mesenchymal transition and stem cell marker expression in lymph node metastasis in early gastric cancer was investigated. | 28595915 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | We evaluated the significance of the expression of 5 epithelial mesenchymal transition-related markers (E-cadherin, MMP7, S100A, Snail-1, and HGF) and 6 stem cell markers (ALDH1, SOX2, CD24, CD44, CD54, and CD133) in 119 early gastric cancer specimens using immunohistochemistry. | 28595915 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | In chronic myeloid leukemia, resistance against BCR-ABL1 tyrosine kinase inhibitors can develop because of BCR-ABL1 mutations, activation of additional pro-oncogenic pathways, and stem cell resistance. | 28596283 |
| Sample Size Calculation | Stem Cell Exhaustion | We treated them by fat grafting, rich in adipose stem cells, and we evaluated through time clinical, functional and aesthetic evaluation of oral pathology associated with SSc. | 28597066 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease was reported in 25/42 patients who received mogamulizumab before allogeneic hematopoietic stem cell transplantation. | 28597329 |
| Hodgkin Disease | Stem Cell Exhaustion | We report on a 30-year-old man with stage IVB Hodgkin lymphoma, who failed nine lines of treatments including high-dose chemotherapy and autologous stem cell transplantation and brentuximab vedotin. | 28597713 |
| GCLC protein, human, Lymphoma, Non-Hodgkin, Shock, Respiratory Failure | Stem Cell Exhaustion | By multivariate analysis, factors independently associated with higher hospital mortality were poor performance status (odds ratio [OR], 3.99; 95%CI, 1.82-9.39; P = 0.0009), non-Hodgkin's lymphoma (OR, 2.60; 95%CI, 1.35-5.15; P = 0.005), shock (OR, 1.95; 95%CI, 1.04-3.72; P = 0.04), and respiratory failure (OR, 2.18; 95%CI, 1.14-4.25; P = 0.02); and factors independently associated with lower hospital mortality were GCS score on day 1 (OR, 0.88/point; 95%CI, 0.81-0.95; P = 0.0009) and autologous stem cell transplantation (OR, 0.25; 95%CI, 0.07-0.75; P = 0.02). | 28598990 |
| Teratoma | Stem Cell Exhaustion | Brief Report: External Beam Radiation Therapy for the Treatment of Human Pluripotent Stem Cell-Derived Teratomas. | 28600830 |
| Teratoma | Stem Cell Exhaustion | Taken together, these results provide proof of concept for the use of EBRT in the treatment of existing teratomas and highlight a strategy to increase the safety of stem cell-based therapies. | 28600830 |
| Virus Diseases | Stem Cell Exhaustion | Impact of stem cell graft on early viral infections and immune reconstitution after allogeneic transplantation in adults. | 28601677 |
| Virus Diseases | Stem Cell Exhaustion | Viral infections are well-known complications after allogeneic stem cell transplant (allo-SCT). | 28601677 |
| Migration, Cell | Stem Cell Exhaustion | Furthermore, we found that overexpressing FZD8 promoted, whereas silencing FZD8 suppressed, PCa cell migration, invasion and stem cell-like phenotypes in vitro, through the activation of canonical Wnt/b-catenin signaling. | 28602974 |
| Multiple Myeloma | Stem Cell Exhaustion | Although outpatient autologous stem cell transplantation (ASCT) is safe and feasible in most instances, some patients undergoing planned outpatient transplantation for multiple myeloma (MM) will need inpatient admission for transplantation-related complications. | 28603071 |
| Malignant tumor of colon | Stem Cell Exhaustion | The characterization of colon cancer stem cells (CSCs) may help to develop novel diagnostic and therapeutic procedures. | 28604612 |
| Specialty Type - cancer | Stem Cell Exhaustion | Emerging evidence has emphasized the importance of cancer therapies targeting an abnormal metabolic state of tumor-initiating cells (TICs) in which they retain stem cell-like phenotypes and nicotinamide adenine dinucleotide (NAD+) metabolism. | 28604662 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Eighty-one patients with high-risk hematological malignancies received unmanipulated haploidentical stem cell transplants (haploSCT) using the same protocol at four Spanish institutions. | 28604667 |
| Negative Regulation of Cell Cycle, Specialty Type - cancer | Stem Cell Exhaustion | Knockdown of SOX9 induced apoptosis, cell-cycle arrest, as well as decreased expression of cancer stem cell markers were determined by Western blot and flow cytometric assays. | 28606919 |
| FBXO8 gene, diabetic | Stem Cell Exhaustion | Compared to data from FBS and normal serum, diabetic serum reduced the stem cell survival and chemotaxis toward VEGF and SDF-1a (P < 0.05). | 28608561 |
| Diabetes Mellitus | Stem Cell Exhaustion | Angiogenic and Restorative Abilities of Human Mesenchymal Stem Cells Were Reduced Following Treatment With Serum From Diabetes Mellitus Type 2 Patients. | 28608561 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | This experiment investigated the impact of serum from patients with type 2 diabetes mellitus on the angiogenic behavior of human mesenchymal stem cells in vitro. | 28608561 |
| diabetic | Stem Cell Exhaustion | Paracrine restorative effect of diabetic stem cells was tested on pancreatic b cells. | 28608561 |
| diabetic | Stem Cell Exhaustion | The paracrine angiogenic potential of diabetic stem cells was disturbed via the changes in the dynamic of Ang-1, Ang-2, and VEGF. | 28608561 |
| Diabetes | Stem Cell Exhaustion | Surface plasmon resonance analysis showed that diabetes could induce an aberrant increase in the interaction of stem cells with endothelial cells. | 28608561 |
| diabetic | Stem Cell Exhaustion | Conditioned media prepared from diabetic stem cells were unable to decrease fatty acid accumulation in b-cells (P < 0.05). | 28608561 |
| diabetic | Stem Cell Exhaustion | The level of insulin secreted by b-cells was not affected after exposure to supernatant from diabetic or non-diabetic mesenchymal stem cells. | 28608561 |
| Diabetes | Stem Cell Exhaustion | Data suggest diabetes could decrease angiogenic and restorative effect of stem cells in vitro. | 28608561 |
| Osteoporotic Fractures | Stem Cell Exhaustion | The present study was designed to evaluate the in vivo effects of zoledronic acid (ZA) on the proliferation and osteoblastic commitment of mesenchymal stem cells (MSC) in osteoporotic patients. | 28608802 |
| Hypoxia | Stem Cell Exhaustion | Enhanced chondrogenesis of bone marrow-derived stem cells by using a combinatory cell therapy strategy with BMP-2/TGF-b1, hypoxia, and COL1A1/HtrA1 siRNAs. | 28611369 |
| Keratopathy | Stem Cell Exhaustion | A 41-year-old man with a history of aniridic keratopathy and limbal stem cell deficiency underwent KLAL in his right eye. | 28614157 |
| Lymphoma, Non-Hodgkin, Familial, Aggressive Adult Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Patients with relapsed aggressive non-Hodgkin lymphoma (NHL) are often treated with platinum-based chemoimmunotherapy regimens in preparation for autologous stem cell transplant. | 28614905 |
| MS gene, White matter atrophy | Stem Cell Exhaustion | Impact of immunoablation and autologous hematopoietic stem cell transplantation on gray and white matter atrophy in multiple sclerosis. | 28617152 |
| Atrophic, MS gene | Stem Cell Exhaustion | Immunoablation and autologous hematopoietic stem cell transplantation (IA/aHSCT) halts relapses, white matter (WM) lesion formation, and pathological whole-brain (WB) atrophy in multiple sclerosis (MS) patients. | 28617152 |
| Histiocytosis, Non-Langerhans-Cell, Lymphoproliferative Disorders | Stem Cell Exhaustion | Non-Langerhans histiocytosis is a group of inflammatory lymphoproliferative disorders originating from non-clonal expansion of hematopoietic stem cells into cytokine-secreting dendritic cells or macrophages. | 28617889 |
| Specialty Type - cancer, Tumor necrosis | Stem Cell Exhaustion | Serum levels of several biomarkers were significantly (p <= 0.001) higher in cancer patients than in healthy controls, particularly alpha-fetoprotein, cancer antigen 15-3, cancer antigen 19-9, migration inhibitory factor, carcinoembryonic antigen, cancer antigen 125, hepatocyte growth factor, soluble Fas, tumor necrosis factor-a, stem cell factor, and osteopontin. | 28618926 |
| Hypertension, CTCAE | Stem Cell Exhaustion | Since HDL mediates important protective actions on the vascular endothelium by increasing the number of circulating endothelial progenitor cells (CD34-positive cells), the level of circulating CD34-positive cells should influence the association between HDL and hypertension. | 28619079 |
| Multiple Myeloma | Stem Cell Exhaustion | The importance of the number of transplanted cells with dipeptidyl peptidase-4 expression on the haematopoietic recovery and lymphocyte reconstitution in patients with multiple myeloma after autologous haematopoietic stem-cell transplantation. | 28620928 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Autologous haematopoietic stem cell transplantation (AHSCT) remains recommended treatment in the first remission in multiple myeloma (MM). | 28620928 |
| Impaired T cell function | Stem Cell Exhaustion | We report that subretinal transplantation of RPE stem cell (RPESC)-derived RPE cells (RPESC-RPE) preserved vision in a rat model of RPE cell dysfunction. | 28625537 |
| Neoplasms | Stem Cell Exhaustion | The levels of miR16 and its targeted genes in tumor tissue of GBM and GBM SGH44, U87, U251 cells as well as their stem cell counterparts were measured by qRT-PCR or western blot or immunohistochemistry. | 28628119 |
| Adult Glioblastoma, Secondary Neoplasm | Stem Cell Exhaustion | Differential expression of miR16 in glioblastoma and glioblastoma stem cells: their correlation with proliferation, differentiation, metastasis and prognosis. | 28628119 |
| Glioblastoma | Stem Cell Exhaustion | The function of miR16 in multiforme glioblastoma multiforme (GBM) and its stem cells (GSCs) remains elusive. | 28628119 |
| Toxic effect, PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Missing HLA C group 1 ligand in patients with AML and MDS is associated with reduced risk of relapse and better survival after allogeneic stem cell transplantation with fludarabine and treosulfan reduced toxicity conditioning. | 28631269 |
| Specialty Type - cancer, Squamous cell carcinoma | Stem Cell Exhaustion | Cancer stem cell markers in patterning differentiation and in prognosis of oral squamous cell carcinoma. | 28631562 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | This study aims to correlate cancer stem cell markers (CD44 and CD147) with tumor differentiation and evaluate their subsequent effect on prognosis. | 28631562 |
| Lip and Oral Cavity Carcinoma, Specialty Type - cancer, Squamous cell carcinoma | Stem Cell Exhaustion | Subsequently, relevance of these cancer stem cell markers in patterning the differentiation characteristics was evaluated in oral squamous cell carcinoma cell lines originating from different grades of oral cancer. | 28631562 |
| Specialty Type - cancer, Squamous cell carcinoma | Stem Cell Exhaustion | Expression profiling indicated higher expression of cancer stem cell and epithelial-mesenchymal transition markers in SCC029B (poorly differentiated squamous cell carcinoma originated; p <= 0.001), which was further translated into increased spheroid formation, migration, and invasion (p < 0.001) as compared to cell line of well-differentiated squamous cell carcinoma origin. | 28631562 |
| Aggressive behavior, Specialty Type - cancer | Stem Cell Exhaustion | Differentiation is a major histological parameter determining tumor aggressiveness and prognosis of the patient; cancer stem cells with their slow dividing and undifferentiated nature might be one of the factors determining the same. | 28631562 |
| Lymphoma, Non-Hodgkin | Stem Cell Exhaustion | He was known to have non-Hodgkin's lymphoma under remission following treatment with chemotherapy and stem cell transplantation, twice. | 28632962 |
| Primary central nervous system lymphoma | Stem Cell Exhaustion | R-MTX-ARA-C followed by autologous stem cell transplantation seems a promising strategy with high response rates in PCNSL. | 28633037 |
| Alzheimers Disease | Stem Cell Exhaustion | Sortilin-Related Receptor Expression in Human Neural Stem Cells Derived from Alzheimer's Disease Patients Carrying the APOE Epsilon 4 Allele. | 28634550 |
| Up | Stem Cell Exhaustion | Here, we analyzed SORL1 expression in neural stem cells (NSCs) from AD patients carrying null, one, or two copies of the APOE4 allele. | 28634550 |
| Retinal ischemia | Stem Cell Exhaustion | Protective Effect of Intravitreal Administration of Exosomes Derived from Mesenchymal Stem Cells on Retinal Ischemia. | 28636406 |
| Hodgkin Disease | Stem Cell Exhaustion | Cost-effectiveness analysis of consolidation with brentuximab vedotin for high-risk Hodgkin lymphoma after autologous stem cell transplantation. | 28640385 |
| Hodgkin Disease, LIPC gene | Stem Cell Exhaustion | In a recent randomized, placebo-controlled trial, consolidation treatment with brentuximab vedotin (BV) decreased the risk of Hodgkin lymphoma (HL) progression after autologous stem cell transplantation (ASCT). | 28640385 |
| Kidney Failure, Chronic, corticotropin-releasing factor, human | Stem Cell Exhaustion | The pathogenic events responsible for the reduction of endothelial progenitor cell (EPC) number and function seen in patients with chronic renal failure (CRF) are poorly understood. | 28641152 |
| Adult Glioblastoma, Glioblastoma | Stem Cell Exhaustion | Glioblastomas have a poor prognosis, possibly because of a subpopulation of therapy-resistant stem cells within the heterogeneous glioblastoma. | 28642175 |
| Adult Glioblastoma | Stem Cell Exhaustion | Because the subventricular zone is the main source of neural stem cells, we aimed at characterizing the subventricular zone using diffusion tensor imaging (DTI) to show subventricular zone involvement in glioblastoma. | 28642175 |
| Specialty Type - cancer | Stem Cell Exhaustion | A small subset of cells, cancer stem cells (CSCs), with self-renewal properties have become a major focus of current cancer research. | 28645102 |
| Hollings Cancer Center | Stem Cell Exhaustion | The eight disease groups we identified were: 1) CK19(-) HCC, 2) CK19(-) scirrhous HCC, 3) CK19(+) HCC, 4) stem cell feature of cHC-CCA, 5) classical cHC-CCA, 6) cholangiolocellular IHCCA, 7) non-cholangiolocellular IHCCA, and 8) EHBCA. | 28645247 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Comparison of matched sibling donors versus unrelated donors in allogeneic stem cell transplantation for primary refractory acute myeloid leukemia: a study on behalf of the Acute Leukemia Working Party of the EBMT. | 28646908 |
| Disease remission | Stem Cell Exhaustion | Allogeneic stem cell transplantation (HSCT) in active disease is an alternative therapeutic strategy. | 28646908 |
| Specialty Type - cancer | Stem Cell Exhaustion | The effect of HOXB7 on expression of cancer stem cell markers was evaluated. | 28646927 |
| Specialty Type - cancer | Stem Cell Exhaustion | Moreover, the cancer stem cell markers EPCAM and NANOG were up-regulated by HOXB7. | 28646927 |
| Healthcare Encounters Domain, Trauma | Stem Cell Exhaustion | HO is most commonly diagnosed in the setting of localized trauma, which results in improper differentiation of progenitor cells, leading to aberrant tissue formation. | 28647521 |
| Degenerative disorder of cartilage | Stem Cell Exhaustion | To clarify whether the peptide can inhibit cartilage degeneration without stimulating bone formation, we first performed a proliferation assay using C3H10T1/2 (the murine mesenchymal stem cell line), which is the common origin of both chondrocytes and osteoblasts. | 28648299 |
| Specialty Type - cancer | Stem Cell Exhaustion | Sam68 Allows Selective Targeting of Human Cancer Stem Cells. | 28648376 |
| Specialty Type - cancer | Stem Cell Exhaustion | Targeting of human cancer stem cells (CSCs) requires the identification of vulnerabilities unique to CSCs versus healthy resident stem cells (SCs). | 28648376 |
| Immune System Diseases | Stem Cell Exhaustion | Mesenchymal stem cells (MSCs) possess immunosuppressive effects, and are widely used for regenerative medicine and immune disorders. | 28648928 |
| Thrombomodulin Alfa | Stem Cell Exhaustion | TMA was retrospectively assessed in 771 patients after allogeneic stem cell transplantation (alloSCT). | 28650448 |
| Specialty Type - cancer, Malignant Meningioma | Stem Cell Exhaustion | It has been proposed that high recurrence rates of malignant meningiomas are linked to cancer stem cells. | 28651379 |
| Graft-vs-Host Disease, Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | BACKGROUND We identified risk factors for acute and chronic graft-versus-host disease (aGVHD and cGVHD, respectively) in recipients after hematopoietic stem cell transplantation (HSCT) from unrelated donors in the China Marrow Donor Program (CMDP). | 28652564 |
| Acute GVH disease | Stem Cell Exhaustion | This HLA-DPB1 GVL effect without induction of severe acute GVHD or deterioration of survival rate has not been reported in unrelated bone marrow or peripheral blood stem cell transplantations, suggesting apparent advantages of UR-CBT. | 28652579 |
| Multiple Myeloma | Stem Cell Exhaustion | Comparison of biosimilar filgrastim, originator filgrastim, and lenograstim for autologous stem cell mobilization in patients with multiple myeloma. | 28653421 |
| Somatic, Fresh Water | Stem Cell Exhaustion | Accumulating evidence indicates that a small RNA-based gene regulatory machinery, the Piwi-piRNA pathway, represents a shared feature of nonaging (potentially immortal) biological systems, including the germline, somatic cancer stem cells, and certain 'lower' eukaryotic organisms like the planarian flatworm and freshwater hydra. | 28653810 |
| Stomatitis | Stem Cell Exhaustion | Impressive tissue regeneration of severe oral mucositis post stem cell transplantation using cord blood platelet gel. | 28656652 |
| Cytomegalovirus Infections, Esophageal Mucositis, Neutropenia, Bacterial sepsis, Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | A patient with non-Hodgkin lymphoma who was undergoing autologous hematopoietic stem cell transplantation developed severe oral and esophageal mucositis with severe bacterial sepsis and cytomegalovirus infection, causing prolonged neutropenia. | 28656652 |
| Pancreatic Ductal Adenocarcinoma, Specialty Type - cancer, Pancreatitis | Stem Cell Exhaustion | Expression and Clinical Significance of Cancer Stem Cell Markers CD24, CD44, and CD133 in Pancreatic Ductal Adenocarcinoma and Chronic Pancreatitis. | 28659655 |
| Specialty Type - cancer, Carcinogenesis | Stem Cell Exhaustion | Cancer stem cells (CSC) play an important role in pancreatic carcinogenesis and prognosis. | 28659655 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Long-Term Outcome of Autologous Hematopoietic Stem Cell Transplantation (AHSCT) for Acute Myeloid Leukemia (AML)- Single Center Retrospective Analysis. | 28660547 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | For patients with acute myeloid leukemia (AML) in complete remission without an acceptable HLA donor, the autologous hematopoietic stem cell transplantation (AHSCT) may remain a therapeutic option as remission consolidation, however its role is still a subject of continued debate. | 28660547 |
| Lymphoproliferative Disorders | Stem Cell Exhaustion | Prior to transplantation of hematopoietic stem cells or solid organ, donor and recipient EBV serostatus has to be determined to assess risks of post-transplant lymphoproliferative disorders. | 28661055 |
| Toxoplasmosis, Cerebral | Stem Cell Exhaustion | Cerebral toxoplasmosis after haematopoietic stem cell transplantation. | 28664700 |
| Communicable Diseases | Stem Cell Exhaustion | The infection is severe and difficult to diagnose in patients receiving allogeneic haematopoietic stem cell transplantation (HSCT). | 28664700 |
| Toxoplasmosis, Cerebral, Fanconi Anemia | Stem Cell Exhaustion | The case is presented of cerebral toxoplasmosis in a 17-year-old youth with Fanconi anaemia treated with haematopoietic stem cell transplantation (HSCT). | 28664700 |
| Serous Cystadenocarcinoma, Carcinoma in situ of fallopian tube | Stem Cell Exhaustion | As many epithelial transitional regions contain stem cells, we also determined the expression of stem cell markers in the normal fallopian tube, tubal intraepithelial lesions and high-grade serous carcinomas. | 28664938 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Spliced variant isoforms of CD44 (CD44v) are a marker of cancer stem cells in solid tumors. | 28667792 |
| Cessation of life, Specialty Type - cancer | Stem Cell Exhaustion | The serum concentration of free CD44v protein was increased after the first cycle of treatment, possibly reflecting death of cancer stem cells. | 28667792 |
| diabetic | Stem Cell Exhaustion | Impact of statin therapy intensity on endothelial progenitor cells after percutaneous coronary intervention in diabetic patients. | 28668399 |
| diabetic | Stem Cell Exhaustion | A low number (that is, <=0.0038 per 100 peripheral mononuclear cells) of circulating endothelial progenitor cells (EPC) is common in diabetic patients. | 28668399 |
| Mycoses | Stem Cell Exhaustion | Epidemiology and Risk Factors for Invasive Fungal Diseases among Allogeneic Hematopoietic Stem Cell Transplant Recipients in Korea: Results of "RISK" Study. | 28668492 |
| Mycoses | Stem Cell Exhaustion | Incidence, epidemiology, and risk factors of invasive fungal diseases (IFDs) in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients can vary from different cohorts and countries. | 28668492 |
| Multiple Myeloma | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplantation (ASCT) is an established treatment for multiple myeloma (MM), yet the impact of transplanted CD34+ cell dose remains unresolved, especially in patients over the age of 65 years. | 28669690 |
| Graft-vs-Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Knowing the impact of chronic graft-versus-host disease (GVHD) on quality of life (QoL) after allogeneic hematopoietic stem cell transplantation (allo-HCT) by GVHD type and severity is critical for providing care to transplant survivors. | 28669922 |
| Comorbidity | Stem Cell Exhaustion | Hematopoietic Cell Transplantation-Specific Comorbidity Index Predicts Morbidity and Mortality in Autologous Stem Cell Transplantation. | 28669923 |
| Haiti | Stem Cell Exhaustion | Further investigations are necessary to establish whether this stem cell-based therapy approach in HT could avoid lifetime hormone replacement therapy by inducing T-cell education. | 28673339 |
| Hashimoto Disease | Stem Cell Exhaustion | Human limbal fibroblast-like stem cells induce immune-tolerance in autoreactive T lymphocytes from female patients with Hashimoto's thyroiditis. | 28673339 |
| Nephroblastoma, Myeloid neoplasm | Stem Cell Exhaustion | Clinical Utility of Wilms' Tumor 1 Monitoring in Patients with Myeloid Malignancy and Prior Allogeneic Hematopoietic Stem Cell Transplantation. | 28673850 |
| Myeloid neoplasm | Stem Cell Exhaustion | Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) is 1 of the standard treatments for myeloid malignancy, relapse remains a major obstacle to cure. | 28673850 |
| Leukemia, Myelocytic, Acute, Deficit | Stem Cell Exhaustion | Evidence for a pre-existing telomere deficit in non-clonal hematopoietic stem cells in patients with acute myeloid leukemia. | 28674830 |
| Multiple Myeloma | Stem Cell Exhaustion | Here, we present the results of an open-label single-arm pilot study in patients with multiple myeloma undergoing autologous stem cell transplantation (ASCT) to assess the safety and efficacy of desipramine combined with G-SCF to induce HSC mobilization. | 28675459 |
| Multiple Myeloma | Stem Cell Exhaustion | Stimulation of adrenergic activity by desipramine enhances hematopoietic stem and progenitor cell mobilization along with G-CSF in multiple myeloma: A pilot study. | 28675459 |
| Hematopoietic, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The successful immunotherapy of acute myeloid leukemia (AML) has been hampered because most potential antigenic targets are shared with normal hematopoietic stem cells (HSCs), increasing the risk of sustained and severe hematopoietic toxicity following treatment. | 28676343 |
| Charcot-Marie-Tooth Disease, Charcot-Marie-Tooth disease, X-linked, 1 | Stem Cell Exhaustion | Generation of induced pluripotent stem cell (iPSC) line from a 36-year-old Charcot-Marie-Tooth disease patient with GJB1 mutation (CMTX). | 28677541 |
| Charcot-Marie-Tooth disease, X-linked, 1 | Stem Cell Exhaustion | We generated induced pluripotent stem cell (iPSC) line from 36-year-old CMTX disease patient by electroporation of skin fibroblasts with episomal vectors encoding OCT4, SOX2, KLF4, L-MYC, LIN28 and shRNA-p53. | 28677541 |
| Multiple Myeloma | Stem Cell Exhaustion | Telomere length is positively associated with the expression of IL-6 and MIP-1a in bone marrow mesenchymal stem cells of multiple myeloma. | 28677723 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Potential roles of mesenchymal stem cells (MSCs) in the pathogenesis of multiple myeloma (MM) are largely unknown. | 28677723 |
| Specialty Type - cancer, Adenocarcinoma of large intestine | Stem Cell Exhaustion | Expression of epithelial-mesenchymal transition and cancer stem cell markers in colorectal adenocarcinoma: Clinicopathological significance. | 28677737 |
| Specialty Type - cancer, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Cancer stem cells (CSCs) display stemness features and might be implicated in tumor initiation, local recurrence and metastasis. | 28677737 |
| Hematologic Neoplasms | Stem Cell Exhaustion | To evaluate the cost-effectiveness of a lifestyle modification program targeting long-term survivors of hematological malignancy treated with hemopoietic stem cell transplantation, a multistate life table Markov model was used to calculate health outcomes for both the intervention and no intervention. | 28678411 |
| Chronic Lymphocytic Leukemia, Virus Diseases, Squamous cell carcinoma | Stem Cell Exhaustion | Prevalence of cutaneous viral infections in incident cutaneous squamous cell carcinoma detected among chronic lymphocytic leukemia and hematopoietic stem cell transplant patients. | 28679298 |
| Graft-vs-Host Disease, Cessation of life | Stem Cell Exhaustion | Graft-versus-host disease (GvHD)-free, relapse-free survival (GRFS) is a recently reported composite endpoint that allows to simultaneously estimate risk of death, relapse and GvHD after allogeneic hematopoietic stem cell transplantation (HSCT). | 28679328 |
| altretamine/cisplatin/cyclophosphamide protocol | Stem Cell Exhaustion | Analysis of differential expression of miR-223 in platelets of elderly CHD patients before and after the autologous stem cell transplantation. | 28682424 |
| Coronary heart disease, altretamine/cisplatin/cyclophosphamide protocol | Stem Cell Exhaustion | The aim of this study was to investigate the differential expression of miR-223 in the platelets of elderly patients with coronary heart disease (CHD) before and after autologous stem cell transplantation. | 28682424 |
| altretamine/cisplatin/cyclophosphamide protocol | Stem Cell Exhaustion | Compared to the levels before the treatment, the results of flow cytometry revealed that the phosphorylation levels of VASP in platelet of CHD patients who received the autologous stem cell transplantation was significantly increased (p<0.05). | 28682424 |
| altretamine/cisplatin/cyclophosphamide protocol | Stem Cell Exhaustion | The results of qRT-PCR showed that the expressions of Ago-2 and miR-223 in elderly CHD patients were significantly increased after autologous stem cell transplantation compared to those before the treatment with statistically significant differences (p<0.05). | 28682424 |
| altretamine/cisplatin/cyclophosphamide protocol | Stem Cell Exhaustion | Therefore, the miR-223 expression of platelets was significantly decreased after elderly CHD patients received autologous stem cell transplantation. | 28682424 |
| Anemia, Sickle Cell, GDC Comorbidity Terminology, Anemia, Ulcer | Stem Cell Exhaustion | Sickle Cell Anemia and Comorbid Leg Ulcer Treated With Curative Peripheral Blood Stem Cell Transplantation. | 28682672 |
| Anemia, Sickle Cell, Renal carnitine transport defect | Stem Cell Exhaustion | Allogeneic bone marrow transplantation or peripheral blood stem cell transplantation (PBSCT) are the only curative therapies for patients with sickle cell disease (SCD). | 28682672 |
| Multiple Myeloma | Stem Cell Exhaustion | High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) has a well-established role in the treatment of patients with multiple myeloma. | 28684379 |
| Liver carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | The effects of the location of cancer stem cell marker CD133 on the prognosis of hepatocellular carcinoma patients. | 28687090 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | CD133 (prominin-1) is widely believed to be a cancer stem cell marker in various solid tumor types, and CD133 has been correlated with tumor-initiating capacity. | 28687090 |
| Papillary thyroid carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Prognostic value of putative cancer stem cell markers (CD24, CD44, CD133, and ALDH1) in human papillary thyroid carcinoma. | 28687160 |
| Specialty Type - cancer | Stem Cell Exhaustion | We hypothesized that cancer stem cells (CSCs) are responsible for the poor outcome and aggressive clinicopathological factors. | 28687160 |
| Acute GVH disease | Stem Cell Exhaustion | Associations between acute GVHD-related biomarkers and endothelial cell activation after allogeneic hematopoietic stem cell transplantation. | 28687251 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (HSCT) can cause serious transplant-related complications such as graft-versus-host disease (GVHD). | 28687251 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | We show that the expression levels of SOX5, SOX6, and SOX21 (SOX5/6/21) transcription factors increase in stem cells of the subventricular zone (SVZ) upon oncogenic stress, whereas their expression in human glioma decreases during malignant progression. | 28687615 |
| Neoplasms | Stem Cell Exhaustion | Altogether, these results provide evidence that SOX5/6/21 play a central role in driving a tumor suppressor response in brain stem cells upon oncogenic insult. | 28687615 |
| Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Haploidentical Hematopoietic Cell Transplant with Post-Transplant Cyclophosphamide and Peripheral Blood Stem Cell Grafts in Older Adults with Acute Myeloid Leukemia or Myelodysplastic Syndrome. | 28688919 |
| Kidney Failure, Chronic | Stem Cell Exhaustion | Ninety-six percent received bortezomib and 44% stem cell transplantation as well as bortezomib, 68% achieved complete or very good partial hematologic response (CR/VGPR), 34% had ESRD, and 39% RR. | 28689003 |
| Cytomegalovirus Infections | Stem Cell Exhaustion | We previously showed that GSH levels in plasma, as measured by untargeted 1H nuclear magnetic resonance, are higher in allogeneic stem cell transplant (allo-SCT) recipients who subsequently develop CMV viraemia. | 28691896 |
| Eye Injuries | Stem Cell Exhaustion | Is there a role for stem cells in treating articular injury? | 28692374 |
| Cartilage injury | Stem Cell Exhaustion | Stem cells may hold the answer to the age-old problem of articular cartilage injury but more robust evidence is required. | 28692374 |
| Have Been Vomiting, Refractory Chemotherapy-Induced Nausea and Vomiting | Stem Cell Exhaustion | Olanzapine Reduces Chemotherapy-induced Nausea and Vomiting Compared With Aprepitant in Myeloma Patients Receiving High-dose Melphalan Before Stem Cell Transplantation: A Retrospective Study. | 28694084 |
| Chemotherapy-induced nausea and vomiting, Chemotherapy-induced Nausea and Vomiting Questionnaire | Stem Cell Exhaustion | Acute and delayed chemotherapy-induced nausea and vomiting (CINV) occurs in most patients who receive high-dose melphalan and significantly affects patients' quality of life during autologous stem cell transplantation. | 28694084 |
| Chemotherapy-induced Nausea and Vomiting Questionnaire | Stem Cell Exhaustion | A retrospective study was conducted to compare the effectiveness of olanzapine- versus aprepitant-based regimens for CINV prevention in adult hematopoietic stem cell recipients who received high-dose melphalan. | 28694084 |
| leukemia | Stem Cell Exhaustion | Allogeneic Hematopoietic Stem Cell Transplantation with Myeloablative Conditioning Is Associated with Favorable Outcomes in Mixed Phenotype Acute Leukemia. | 28694182 |
| Up | Stem Cell Exhaustion | The TRPC6 reduction in AD patients was further confirmed in blood RNA samples from The Australian Imaging, Biomarkers and Lifestyle Flagship Study of Aging, in post-mortem brain tissues from The Netherlands Brain Bank and in induced pluripotent stem cells-derived neurons from Chinese donors. | 28696436 |
| Fracture, Nonunion of Bone | Stem Cell Exhaustion | Atrophic and oligotrophic nonunions have poor biology at the fracture site to promote bone growth and would therefore benefit from autogenous iliac bone graft, as this technique is osteoinductive, osteoconductive, and osteogenic stem cells. | 28697075 |
| Adult T-Cell Lymphoma/Leukemia, Hypoxia | Stem Cell Exhaustion | Analyses of global gene expression profiles of ASXL1-mutated versus wild-type human leukemia cells as well as heterozygote versus wild-type mouse marrow precursor cells, with or without MN1 overexpression, highlighted the association of in vivo Asxl1 mutation to the expression of hypoxia, multipotent progenitors, hematopoietic stem cells, KRAS, and MEK gene sets. | 28697759 |
| Ischemia | Stem Cell Exhaustion | Improvement in asymmetric dimethylarginine and oxidative stress in patients with limb salvage after autologous mononuclear stem cell application for critical limb ischemia. | 28697789 |
| Malignant neoplasm of breast, Childhood Breast Carcinoma, Triple Negative Breast Neoplasms | Stem Cell Exhaustion | Here we immunohistochemically studied expression patterns of CLDNs in 222 primary invasive breast cancers including 68 triple-negative breast cancers (TNBCs), and examined their correlation with epithelial-to-mesenchymal transition (EMT)-related markers, breast cancer stem cell (BCSC) markers, and clinicopathological features including patients' clinical outcome. | 28699235 |
| Tissue damage, Amyloidosis | Stem Cell Exhaustion | Elevation of serum lactate dehydrogenase in AL amyloidosis reflects tissue damage and is an adverse prognostic marker in patients not eligible for stem cell transplantation. | 28699650 |
| Cessation of life | Stem Cell Exhaustion | Elevated LDH was an independent prognostic marker for overall survival and for death within 6 months of diagnosis, but this was restricted to patients not eligible for stem cell transplant. | 28699650 |
| Specialty Type - cancer | Stem Cell Exhaustion | Only ZEB1 was significantly associated with cancer stem cell (CSC) markers. | 28700115 |
| Malignant melanoma of conjunctiva | Stem Cell Exhaustion | A 69-year-old with conjunctival melanoma on her left eye developed total limbal stem cell deficiency (LSCD) after multiple cycles of topical mitomycin. | 28700252 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Dysregulation of a novel miR-23b/27b-p53 axis impairs muscle stem cell differentiation of humans with type 2 diabetes. | 28702332 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | In the current study, we describe an impaired myogenic capacity of muscle stem cells isolated from humans with type 2 diabetes (T2DM) and assess whether this phenotype is regulated by miRNAs. | 28702332 |
| Viremia | Stem Cell Exhaustion | Dynamics of Torque Teno virus viremia could predict risk of complications after allogeneic hematopoietic stem cell transplantation. | 28702856 |
| Hematological Disease | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an established treatment option for several hematological diseases. | 28702856 |
| Hemolysis (biological function) | Stem Cell Exhaustion | Transient hemolysis due to anti-D and anti-A1 produced by engrafted donor's lymphocytes after allogeneic unmanipulated haploidentical hematopoietic stem cell transplantation. | 28703860 |
| Immune-mediated | Stem Cell Exhaustion | Although rabbit anti-T-lymphocyte globulin (ATLG) is largely used for the prevention of immune-mediated complications in patients given allogeneic haemopoietic stem-cell transplantation (HSCT) from an unrelated donor, the optimum dose of this drug in children is still undefined. | 28705454 |
| Neoplasms | Stem Cell Exhaustion | b-catenin is a cell-cell adhesion protein, whose nuclear localization has been linked to the pathogenesis of adaCP: its nuclear accumulation is associated to the presence of a tumor stem cell subpopulation. | 28709442 |
| Craniopharyngioma | Stem Cell Exhaustion | In this study, we measured the immunohistochemical expression of b-catenin, stem cell markers (CD133, CD166), Ki67 and pATMin 45 craniopharyngiomas and correlated it with clinicopathologic features. | 28709442 |
| Specialty Type - cancer | Stem Cell Exhaustion | This fact, and the uncovering of the genetic basis of plasticity in somatic cells and cancer stem cells, open a door to a world where maintenance and regeneration of organ systems maintain health and extend life expectancy beyond its present limits. | 28710142 |
| Failure, leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Leukemia stem cells (LSCs) are considered to be the cause of treatment failure and relapse in acute myeloid leukemia (AML). | 28710745 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | As LSCs and hematopoietic stem cells (HSCs) are enriched in CD34+CD38- populations, CD34+CD38- cells from KG1a and Kasumi-1 cell lines as well as CD34+ blasts from AML patients were used as LSC models, while CD34+ cells from healthy donors were used as normal hematopoietic cells. | 28710745 |
| Myeloid neoplasm | Stem Cell Exhaustion | A Chemotherapy-Only Regimen of Busulfan, Melphalan, and Fludarabine, and Rabbit Antithymocyte Globulin Followed by Allogeneic T-Cell Depleted Hematopoietic Stem Cell Transplantations for the Treatment of Myeloid Malignancies. | 28711727 |
| Graft-vs-Host Disease, Toxic effect | Stem Cell Exhaustion | We sought to develop a myeloablative chemotherapeutic regimen to secure consistent engraftment of T-cell depleted (TCD) hematopoietic stem cell transplantations (HSCT) without the need for total body irradiation, thereby reducing toxicity while maintaining low rates of graft-versus-host disease (GVHD) and without increasing relapse. | 28711727 |
| Bone graft - material | Stem Cell Exhaustion | TCD was accomplished by CD34+-selection followed by E-rosette depletion for peripheral blood stem cell grafts and, for bone marrow grafts, by soybean agglutination followed by E-rosette depletion. | 28711727 |
| Relapsing course | Stem Cell Exhaustion | Phase II Study of Sequential Infusion of Donor Lymphocyte Infusion and Cytokine-Induced Killer Cells for Patients Relapsed after Allogeneic Hematopoietic Stem Cell Transplantation. | 28712935 |
| Stable chronic Graft vs Host Disease | Stem Cell Exhaustion | By multivariate analysis, the type of relapse, the presence of cGVHD, and a short (<6 months) time from allogeneic hematopoietic stem cell transplantation to relapse were the significant predictors of survival. | 28712935 |
| End Stage Liver Disease | Stem Cell Exhaustion | Effects of age on biological and functional characterization of adipose-derived stem cells from patients with end-stage liver disease. | 28713938 |
| Encephalitis | Stem Cell Exhaustion | Dengue encephalitis in allogenic hematopoietic stem cell transplantation recipient. | 28714943 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Expression profiling revealed 780 genes for which the expression level was affected by the loss of DIP2C, including the tumour-suppressor encoding CDKN2A gene, the epithelial-mesenchymal transition (EMT) regulator-encoding ZEB1, and CD44 and CD24 that encode breast cancer stem cell markers. | 28716088 |
| Wiskott-Aldrich Syndrome, WAS protein, human | Stem Cell Exhaustion | Until recently, hematopoietic stem cell transplantation was the only curative option for Wiskott-Aldrich syndrome (WAS). | 28716862 |
| Hemoglobinuria, Non-Malignant | Stem Cell Exhaustion | Paroxysmal nocturnal haemoglobinuria is a non-malignant stem cell disorder due to acquired somatic mutations in cell surface anchored proteins CD55 and CD59. | 28718265 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Expression of embryonic stem cell markers in acute myeloid leukemia. | 28718379 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The aim of our study was to evaluate the expression of embryonic antigens (OCT4, NANOG, SOX2, SSEA1, SSEA3) in hematopoietic stem cell subsets (CD34+CD38- and CD34+CD38+) from normal bone marrows and in samples from acute myeloid leukemia patients. | 28718379 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Acute myeloid leukemia is driven by leukemic stem cells which can be identified by cross lineage expression or arrest of differentiation compared to normal hematopoietic stem cells. | 28718379 |
| Sample Size Calculation | Stem Cell Exhaustion | Given the difficulty in treating SSc, we conducted this study to investigate the effect of combined plasmapheresis (PE) and allogeneic mesenchymal stem cells transplantation (MSCT) therapy on SSc. | 28724445 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Decrease in Vancomycin-Resistant Enterococcus Colonization After Extensive Renovation of a Unit Dedicated to the Treatment of Hematologic Malignancies and Hematopoietic Stem-Cell Transplantation. | 28724453 |
| Hemopoietic stem cell transplant | Stem Cell Exhaustion | SETTING A regional referral center for acute leukemia and hematopoietic stem-cell transplantation. | 28724453 |
| Acute leukemia | Stem Cell Exhaustion | PATIENTS Overall, 536 consecutive hospital admissions for newly diagnosed acute leukemia or a first autologous or allogeneic stem-cell transplantation were reviewed. | 28724453 |
| Malignant Neoplasms | Stem Cell Exhaustion | Randomized controlled trial on the effects of a supervised high intensity exercise program in patients with a hematologic malignancy treated with autologous stem cell transplantation: Results from the EXIST study. | 28727771 |
| Fatigue, Multiple Myeloma | Stem Cell Exhaustion | This single blind, multicenter randomized controlled trial aimed to evaluate the effectiveness of a supervised high intensity exercise program on physical fitness and fatigue in patients with multiple myeloma or lymphoma recently treated with autologous stem cell transplantation. | 28727771 |
| B-Cell Lymphomas, Myeloma cell | Stem Cell Exhaustion | Quantification of marrow hematogones following autologous stem cell transplant in adult patients with plasma cell myeloma or diffuse large B-cell lymphoma and correlation with outcome. | 28728454 |
| Myeloma cell | Stem Cell Exhaustion | In this retrospective study, we quantified the hematogone (normal B-lineage precursor) population by flow cytometric immunophenotyping in post-transplant bone marrow biopsy specimens from adult patients who received an autologous stem cell transplant for either plasma cell myeloma (n = 57) or diffuse large B-cell lymphoma (n = 73). | 28728454 |
| Diabetes | Stem Cell Exhaustion | Psychosocial Response to New-Onset Diabetes as a Long-Term Effect of Allogeneic Hematopoietic Stem Cell Transplantation. | 28728478 |
| Allogeneic Hematopoietic Stem Cell Transplantation, Diabetes, Hematologic Neoplasms | Stem Cell Exhaustion | Currently, little information is available to guide health care practitioners on how to facilitate positive outcomes in individuals who develop new-onset diabetes after allogeneic hematopoietic stem cell transplantation (allo HSCT) for treatment of hematological cancers. | 28728478 |
| Glaucoma, CTCAE | Stem Cell Exhaustion | Given its inherent population of stem cells, our hypothesis was that this highly replicative, biological tissue would provide an adequate means of glaucoma tube coverage. | 28731936 |
| HIV Infections | Stem Cell Exhaustion | However, CCR5-tropic HIV infection is limited to more differentiated progenitor cells with life spans that are less well understood. | 28732051 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Long-Term Results of High-Dose Therapy and Autologous Stem Cell Transplantation for Mantle Cell Lymphoma: Effectiveness of Maintenance Rituximab. | 28733266 |
| Medial collateral ligament, Mantle cell lymphoma | Stem Cell Exhaustion | High-dose therapy followed by autologous stem cell transplantation (ASCT) can improve outcomes for mantle cell lymphoma (MCL) but is associated with a high incidence of relapse. | 28733266 |
| Hematologic Neoplasms | Stem Cell Exhaustion | T Cell Depletion as an Alternative Approach for Patients 55 Years or Older Undergoing Allogeneic Stem Cell Transplantation as Curative Therapy for Hematologic Malignancies. | 28734876 |
| Graft-vs-Host Disease, Hematologic Neoplasms | Stem Cell Exhaustion | T cell-depleted (TCD) allogeneic hematopoietic stem cell transplantation (HSCT) is curative treatment for hematologic malignancies in adults, shown to reduce graft-versus-host disease (GVHD) without increased relapse. | 28734876 |
| Malignant Neoplasms | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (HSCT) has been used as treatment in different hematologic and solid malignancies. | 28736021 |
| Multiple Myeloma, Cytopenia | Stem Cell Exhaustion | Outcomes of salvage autologous stem cell transplantation for multiple myeloma with cytopenias and exposure to novel agents. | 28737774 |
| Degenerative polyarthritis | Stem Cell Exhaustion | The Stem-Cell Market for the Treatment of Knee Osteoarthritis: A Patient Perspective. | 28738432 |
| Degenerative polyarthritis | Stem Cell Exhaustion | The use of stem-cell therapies for the treatment of various musculoskeletal conditions, especially knee osteoarthritis (OA), is rapidly expanding, despite only low-level evidence to support its use. | 28738432 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Therefore, the purpose of this study was to determine the current marketed: (1) prices and (2) clinical efficacy of stem-cell therapies for knee OA. | 28738432 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Most American stem-cell centers offer therapies for knee OA. | 28738432 |
| Degenerative polyarthritis | Stem Cell Exhaustion | These findings offer both patients and physicians insight into the current stem-cell market for knee OA. | 28738432 |
| Fever, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We present a case of a 61-year-old Caucasian woman who was hospitalized with fever on day 176 after a matched unrelated stem cell transplant for acute myelogenous leukemia. | 28741746 |
| Multiple Myeloma | Stem Cell Exhaustion | Purpose Lenalidomide maintenance therapy after autologous stem-cell transplantation (ASCT) demonstrated prolonged progression-free survival (PFS) versus placebo or observation in several randomized controlled trials (RCTs) of patients with newly diagnosed multiple myeloma (NDMM). | 28742454 |
| Cessation of life | Stem Cell Exhaustion | In multivariate analysis, myeloid immunophenotype, prior TKI, age >=58 years, lactate dehydrogenase level >=1227 IU/L, platelet count < 102 K/mL, no history of stem cell transplantation, transition to BP from chronic phase/accelerated phase, and the presence of chromosome 15 aberrations predicted for a significantly increased risk of death. | 28743165 |
| Heart Diseases | Stem Cell Exhaustion | Mesenchymal stem cells from sternum: the type of heart disease, ischemic or valvular, does not influence the cell culture establishment and growth kinetics. | 28743269 |
| Heart Diseases | Stem Cell Exhaustion | To study the proliferative and differentiation potential of mesenchymal stem cells (MSC), isolated from bone marrow (BM) of sternum, we made a comparative analysis between samples of patients with ischemic (IHD) or non-ischemic valvular (VHD) heart diseases. | 28743269 |
| Hematologic Neoplasms, Aspergillosis | Stem Cell Exhaustion | Patients with hematologic malignancies as well as allogeneic hematopoietic stem cell transplantation (HSCT) patients are at high risk for invasive aspergillosis. | 28743702 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Acute myeloid leukemia is a hematopoietic stem cell neoplastic disease associated with high morbidity and mortality. | 28746590 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The report describes the outcomes of patients with FLT3 internal tandem duplication positive acute myeloid leukemia who relapsed after allogeneic hematopoietic stem cell transplantation and were treated with the combination of re-induction chemotherapy, donor lymphocyte infusion, sorafenib and azacitidine. | 28746590 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The combination of induction chemotherapy followed by donor lymphocyte infusion, and the maintenance with azacitidine and sorafenib can be effective approaches in the treatment of post-hematopoietic stem cell transplant and relapsed FLT3 internal tandem duplication positive acute myeloid leukemia patients. | 28746590 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Intra-articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A 2-Year Follow-up Study. | 28746812 |
| Degenerative polyarthritis, Nasal cartilage loss | Stem Cell Exhaustion | The intra-articular injection of mesenchymal stem cells (MSCs) into the knee has shown a potential for the treatment of generalized cartilage loss in osteoarthritis (OA). | 28746812 |
| Malignant Neoplasms | Stem Cell Exhaustion | Hospital mortality of patients initially not admitted was 29.7% and independently associated with malignancy progression[OR: 3.15(1.6-6.19)], allogeneic hematopoietic stem cell transplantation[OR: 2.5(1.06-5.89)], a request based on a clinical respiratory event[OR: 2.36(1.22-4.56)] and severe sepsis[OR: 0.27(0.08-0.99)]. | 28749989 |
| Premature Menopause | Stem Cell Exhaustion | Many reports have shown that various kinds of stem cells have the ability to recover premature ovarian aging (POA) function. | 28750654 |
| Graft-vs-Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Defective post-transplantation thymopoiesis is associated with chronic graft-versus-host disease (GVHD), a multiorgan pathology affecting up to 80% of patients after allogeneic hematopoietic stem cell transplantation (HSCT). | 28750779 |
| Neoplasms | Stem Cell Exhaustion | An increased grafting rate for tumours derived from patients with worse outcome (p = 0.006), higher stage (p = 0.038) and higher CD133+/CXCR4+/EpCAM- stem cell content (p = 0.019) was observed whereas a trend towards an association with SUVmax higher than 8 (p = 0.084) was detected. | 28751748 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Phase I/II study of the deacetylase inhibitor panobinostat after allogeneic stem cell transplantation in patients with high-risk MDS or AML (PANOBEST trial). | 28751769 |
| Degenerative polyarthritis, Usual Severity Pain | Stem Cell Exhaustion | The effect of intra-articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis. | 28752679 |
| Degenerative polyarthritis | Stem Cell Exhaustion | This was a prospective, open-label, phase I/II clinical trial to assess the safety and efficacy of a single intra-articular injection of autologous stimulated bone marrow stem cells (BM-SC) in patients with knee OA. | 28752679 |
| Amyloidosis | Stem Cell Exhaustion | Comparison of Different Stem Cell Mobilization Regimens in AL Amyloidosis Patients. | 28754546 |
| Amyloidosis | Stem Cell Exhaustion | High-dose melphalan (HDM) and autologous blood stem cell transplantation (ABSCT) is an effective treatment for transplantation-eligible patients with systemic light chain (AL) amyloidosis. | 28754546 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Adipose Progenitor Cell Secretion of GM-CSF and MMP9 Promotes a Stromal and Immunological Microenvironment That Supports Breast Cancer Progression. | 28754674 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | Some researchers thought that PROCR+ cells had cancer stem cell ability, which might contribute to progressive behavior in breast cancer. | 28756987 |
| Idiopathic pneumonia syndrome | Stem Cell Exhaustion | Idiopathic pneumonia syndrome (IPS) is a complication of allogeneic hematopoietic stem cell transplantation (HSCT) that typically occurs within the first 100 days after transplantation. | 28757436 |
| Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Higher rates of relapse in maternal recipients of haploidentical hematopoietic stem cell transplantation from adult offspring donors for AML and myelodysplastic syndrome. | 28759027 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | The eukaryotic gut virome in hematopoietic stem cell transplantation: new clues in enteric graft-versus-host disease. | 28759053 |
| Graft-vs-Host Disease, Inflammatory Bowel Diseases | Stem Cell Exhaustion | Although previously investigated in individuals with inflammatory bowel diseases or solid-organ transplants, virome dynamics in allogeneic hematopoietic stem cell transplantation (HSCT) and enteric graft-versus-host disease (GVHD) remain unexplored. | 28759053 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | The Dutch-Belgian Cooperative Trial Group for Hematology Oncology Group-65/German-speaking Myeloma Multicenter Group-HD4 (HOVON-65/GMMG-HD4) phase III trial compared bortezomib (BTZ) before and after high-dose melphalan and autologous stem cell transplantation (HDM, PAD arm) compared with classical cytotoxic agents prior and thalidomide after HDM (VAD arm) in multiple myeloma (MM) patients aged 18-65 years. | 28761118 |
| Irritable Bowel Syndrome | Stem Cell Exhaustion | This study examined whether the densities of stem- and enteroendocrine cell progenitors are abnormal in the ileum of patients with irritable bowel syndrome (IBS), and whether any abnormalities in ileal enteroendocrine cells are correlated with abnormalities in stem cells and enteroendocrine cell progenitors. | 28764761 |
| Periodontal Route of Administration | Stem Cell Exhaustion | Our findings provide evidence that periodontally affected dental tissue (both pulp and gingiva) can be used as a source of MSCs with intact stem cell properties. | 28764802 |
| Periodontal Route of Administration, Tooth structure | Stem Cell Exhaustion | In this study, we verified the ability of dental pulp mesenchymal stem cells (DPSCs) and gingival mesenchymal stem cells (GMSCs) harvested from periodontally affected teeth to produce new mineralized bone tissue in vitro, and compared this to cells from healthy teeth. | 28764802 |
| Malignant neoplasm of urinary bladder | Stem Cell Exhaustion | The KMT1A-GATA3-STAT3 Circuit Is a Novel Self-Renewal Signaling of Human Bladder Cancer Stem Cells. | 28765327 |
| Malignant neoplasm of urinary bladder, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Bladder cancer stem cells (BCSCs) play a crucial role in tumor initiation, metastasis, and drug resistance. | 28765327 |
| Malignant neoplasm of urinary bladder | Stem Cell Exhaustion | Here, we identified a novel signal, the KMT1A-GATA3-STAT3 circuit, which promoted the self-renewal and tumorigenicity of human BCSCs.Experimental Design: In a discovery step, human BCSCs and bladder cancer non-stem cells (BCNSCs) isolated from primary bladder cancer samples #1 and #2, and the bladder cancer cell line EJ were analyzed by transcriptome microarray. | 28765327 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | The cancer stem cell (CSC) theory of tumor growth indicates that CSCs within the tumor mass have great capacity to initiate and sustain tumor growth. | 28766682 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | Stathmin1 expression is associated with aggressive phenotypes and cancer stem cell marker expression in breast cancer patients. | 28766688 |
| Aggressive behavior, Specialty Type - cancer | Stem Cell Exhaustion | High STMN1 expression is a possible marker of breast cancer aggressiveness in association with proliferation, phenotype and cancer stem cell type. | 28766688 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Few clinical trials have investigated the safety and efficacy of mesenchymal stem cells for the management of post-traumatic osteoarthritis. | 28768528 |
| Glioblastoma Multiforme Pathway, Adult Glioblastoma | Stem Cell Exhaustion | The perivascular niche is critical for intercellular communication between resident cell types in glioblastoma (GBM), and it plays a vital role in maintaining the glioma stem cell (GSC) microenvironment. | 28771552 |
| Graft-vs-Host Disease, Tuberculosis, Hepatic | Stem Cell Exhaustion | Concurrent Hepatic Tuberculosis and Hepatic Graft-versus-host Disease in an Allogeneic Hematopoietic Stem Cell Transplant Recipient: A Case Report. | 28774674 |
| Graft-vs-Host Disease, Communicable Diseases | Stem Cell Exhaustion | Infection and graft-versus-host disease (GVHD) are among the most common complications after hematopoietic stem cell transplantation (HSCT). | 28774674 |
| Childhood Non-Hodgkin Lymphoma, Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | SCHOLAR-1, an international, multicohort retrospective non-Hodgkin lymphoma research study, retrospectively evaluated outcomes in patients with refractory DLBCL which, for this study, was defined as progressive disease or stable disease as best response at any point during chemotherapy (>4 cycles of first-line or 2 cycles of later-line therapy) or relapsed at <=12 months from autologous stem cell transplantation. | 28774879 |
| Compression of umbilical cord, Primary Myelofibrosis, PMF Regimen | Stem Cell Exhaustion | BACKGROUND In Primary Myelofibrosis (PMF; a clonal disorder arising from the neoplastic transformation of early hematopoietic stem cells) patients, spinal cord compression (SCC) is a common complication or even a presentation symptom due to extramedullary hematopoiesis (EMH). | 28775247 |
| Haiti | Stem Cell Exhaustion | Response to HT first-line therapy (HR 5*3, 95% CI: 2*4-12*0), autologous stem cell transplantation (HR 3*9, 95% CI: 1*5-10*1), and revised International Prognostic Index (HR 2*2, 95% CI: 1*1-4*2) were significantly associated with SFT. | 28782811 |
| Congestive heart failure, Ventricular Dysfunction | Stem Cell Exhaustion | Thereafter, she had refractory class IV congestive heart failure with severe right ventricular dysfunction, and was deemed unsuitable for stem-cell or heart transplantation. | 28784887 |
| Bronchiolitis Obliterans | Stem Cell Exhaustion | Bronchiolitis obliterans syndrome has been associated with increased morbidity and mortality after allogeneic hematopoietic stem cell transplant (HSCT). | 28787506 |
| Cardiovascular Diseases | Stem Cell Exhaustion | Endogenous regenerative capacity, assessed as circulating progenitor cell (PC) numbers, is an independent predictor of adverse outcomes in patients with cardiovascular disease. | 28790053 |
| Heart failure | Stem Cell Exhaustion | Progenitor Cells and Clinical Outcomes in Patients With Heart Failure. | 28790053 |
| NBN wt Allele | Stem Cell Exhaustion | Dermal-derived fibroblasts from NBS patients were reprogrammed into induced pluripotent stem cells (iPSCs) in order to bypass premature senescence. | 28790359 |
| Traumatic | Stem Cell Exhaustion | Endothelial Progenitor Cells Correlated with Oxidative Stress after Mild Traumatic Brain Injury. | 28792147 |
| Specialty Type - cancer, Refractory Cytopenia of Childhood | Stem Cell Exhaustion | In this study, we showed that Endoglin (CD105) expression not only demarcates a cancer stem cell subpopulation but also confers self-renewal ability and contributes to chemoresistance in RCC. | 28793246 |
| Malignant neoplasm of kidney, Resistance Process | Stem Cell Exhaustion | Endoglin Is Essential for the Maintenance of Self-Renewal and Chemoresistance in Renal Cancer Stem Cells. | 28793246 |
| Adult Glioblastoma | Stem Cell Exhaustion | The anti-vascular endothelial growth factor receptor-1 monoclonal antibody D16F7 inhibits invasiveness of human glioblastoma and glioblastoma stem cells. | 28797294 |
| Mycoses | Stem Cell Exhaustion | Cytomegalovirus Reactivation Is Associated with Increased Risk of Late-Onset Invasive Fungal Disease after Allogeneic Hematopoietic Stem Cell Transplantation: A Multicenter Study in the Current Era of Viral Load Monitoring. | 28797778 |
| Opportunistic Infections, Intrinsic Factor Deficiency, Mycoses | Stem Cell Exhaustion | Opportunistic infections such as cytomegalovirus (CMV) reactivation and invasive fungal disease (IFD) cause significant morbidity and mortality to recipients of hematopoietic stem cell transplant (HSCT). | 28797778 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Results of a Prospective Randomized, Open-Label, Noninferiority Study of Tbo-Filgrastim (Granix) versus Filgrastim (Neupogen) in Combination with Plerixafor for Autologous Stem Cell Mobilization in Patients with Multiple Myeloma and Non-Hodgkin Lymphoma. | 28797783 |
| Lymphoma, Non-Hodgkin, Familial, Morular Metaplasia of the Endometrium, Childhood Non-Hodgkin Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplantation (auto-HSCT) improves survival in patients with multiple myeloma (MM) and non-Hodgkin lymphoma (NHL). | 28797783 |
| Toxic effect | Stem Cell Exhaustion | In retrospective studies, stem cell mobilization with tbo-filgrastim has shown similar efficacy and toxicity as filgrastim, but no prospective studies have been published to date. | 28797783 |
| Lymphoma, Non-Hodgkin, Familial | Stem Cell Exhaustion | We have conducted the first prospective randomized trial comparing the safety and efficacy of tbo-filgrastim in combination with plerixafor with that of filgrastim in combination with plerixafor for stem cell mobilization in patients with MM and NHL. | 28797783 |
| Lymphoma, Non-Hodgkin, Familial, Morular Metaplasia of the Endometrium | Stem Cell Exhaustion | Tbo-filgrastim is not inferior in efficacy and has similar safety compared to reference filgrastim when used for stem cell mobilization in patients with MM and NHL. | 28797783 |
| Lymphoma, Non-Hodgkin, Familial, Morular Metaplasia of the Endometrium | Stem Cell Exhaustion | Granix can be safely used instead of Neupogen for stem cell collection in patients undergoing auto-HSCT for MM or NHL. | 28797783 |
| Immunocompromised Host, Communicable Diseases | Stem Cell Exhaustion | Recipients of allogeneic haematopoietic stem cell transplantation (allo-HSCT) are severely immunocompromised and are at increased risk of infection. | 28797807 |
| Anemia, Sickle Cell, Acute onset pain | Stem Cell Exhaustion | Acute pain crisis in a patient with sickle cell disease undergoing ovarian simulation for fertility preservation prior to curative stem cell transplantation: case report and literature review. | 28801781 |
| Anemia, Sickle Cell, Renal carnitine transport defect | Stem Cell Exhaustion | Hematopoietic stem cell transplantation (HSCT) is a cure for sickle cell disease (SCD) but frequently results in permanent sterility. | 28801781 |
| Malignant Neoplasms, Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | Cancer stem cells/cancer-initiating cells (CICs) and their microenvironmental niche play a vital role in malignant tumour recurrence and metastasis. | 28802057 |
| Somatic mutation | Stem Cell Exhaustion | Clonal hematopoiesis (CH), as evidenced by recurrent somatic mutations in leukemia-associated genes, commonly occurs among aging human hematopoietic stem cells. | 28803919 |
| Hematologic Neoplasms, Neoplasms | Stem Cell Exhaustion | These data suggest that CH occurs in an age-dependent manner and that specific perturbations can enhance fitness of clonal hematopoietic stem cells, which can impact outcome through progression to hematologic malignancies and through cell-non-autonomous effects on solid tumor biology. | 28803919 |
| Subependymal Glioma, Neoplasms | Stem Cell Exhaustion | Subependymomas demonstrate mixed populations of cells expressing glial lineage markers as well as putative stem cell markers, suggesting these tumors may arise from multipotent glial progenitors that reside in the subventricular zone. | 28804038 |
| Sample Size Calculation | Stem Cell Exhaustion | Gene candidates were identified through microarray experiments performed on Affymetrix GeneChip Human Exon 1.0 ST arrays in endothelial progenitor cell (EPC)-derived endothelial cells (ECs) obtained from patients with SSc-associated PH, patients with SSc without PH, and healthy control subjects. | 28805015 |
| Extramedullary, Multiple Myeloma | Stem Cell Exhaustion | Multiple myeloma with extramedullary disease: impact of autologous stem cell transplantation on outcome. | 28805789 |
| Multiple Myeloma, Infection, Morular Metaplasia of the Endometrium | Stem Cell Exhaustion | Patients with multiple myeloma (MM) who undergo autologous stem cell transplantation (ASCT) are susceptible to severe infections. | 28805791 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | MRP1 protein expression in leukemic stem cells as a negative prognostic marker in acute myeloid leukemia patients. | 28805931 |
| Eye | Stem Cell Exhaustion | we report a 13 years old asian male patient rare case of ocular KS that was initiated from the sclera and progressed into the cornea and conjunctiva without an human Immunodeificiency Virus (HIV) or HHV-8 infection after a peripheral blood stem cells transplantation. | 28806949 |
| Hair follicle structure | Stem Cell Exhaustion | Stem cells for the epidermis and hair follicle are located in the bulge area of the hair follicle with the potential to differentiate into multiple lineages. | 28809777 |
| Skin Squamous Cell Carcinoma or Other Skin Carcinomas TNM Finding v7, Squamous cell carcinoma of skin | Stem Cell Exhaustion | Multiple cutaneous carcinomas, including follicular cutaneous squamous cell carcinoma (FSCC), are thought to arise from stem cells in the follicular bulge. | 28809777 |
| Specialty Type - cancer | Stem Cell Exhaustion | Furthermore, ALCAM is considered one of the cancer stem cell markers such as ALDH1 (ALDH1A1) and SALL4. | 28811252 |
| Specialty Type - cancer, Malignant Pleural Mesothelioma | Stem Cell Exhaustion | In this study, 175 well-characterized primary diffuse pleural mesotheliomas, including the epithelioid (n = 148), biphasic (n = 15), and sarcomatoid (n = 12) histotypes, were evaluated immunohistochemically for cancer stem cell markers (ALCAM, ALDH1, and SALL4) and PD-L1 expression. | 28811252 |
| LMNA wt Allele | Stem Cell Exhaustion | To address this need, we produced a functional three-dimensional model of HGPS that replicates an arteriole-scale tissue engineered blood vessel (TEBV) using induced pluripotent stem cell (iPSC)-derived SMCs from an HGPS patient. | 28811655 |
| LMNA wt Allele | Stem Cell Exhaustion | To isolate the effect of the HGPS iSMCs, the endothelial layer consisted of human cord blood-derived endothelial progenitor cells (hCB-EPCs) from a separate, healthy donor. | 28811655 |
| Specialty Type - cancer, Ovarian Carcinoma | Stem Cell Exhaustion | CD44 as a cancer stem cell marker and its prognostic value in patients with ovarian carcinoma. | 28816557 |
| Epithelial ovarian cancer, Specialty Type - cancer | Stem Cell Exhaustion | The aim of our study was to clarify whether the CD44 adhesion molecule as a cancer stem cell marker could also serve as a prognostic factor in patients with epithelial ovarian cancer (EOC). | 28816557 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells (CSCs) are subpopulations of cells with typical characteristics of stem cells - i.e. | 28816557 |
| Central neuroblastoma | Stem Cell Exhaustion | The patient underwent treatment for high-risk neuroblastoma comprising chemotherapy including cisplatin, etoposide, vindesine, dacarbacine, ifosfamide, vincristine, adriamycine and autologous stem cell transplantation followed by maintenance therapy with 13-cis retinoic acid (GPOH NB2004 High Risk Trial Protocol) and is in complete long-term remission. | 28818093 |
| Takotsubo Cardiomyopathy | Stem Cell Exhaustion | Catecholamine-Dependent b-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy. | 28818208 |
| Medial collateral ligament | Stem Cell Exhaustion | In conclusion, we show that TP53 mutations identify a phenotypically distinct and highly aggressive form of MCL with poor or no response to regimens including cytarabine, rituximab, and autologous stem-cell transplant (ASCT). | 28819011 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Graft-versus-host disease (GVHD) is a leading cause of morbidity and mortality in allogeneic hematopoietic stem cell transplantation (alloHCT). | 28821454 |
| Chronic Kidney Disease, CTCAE | Stem Cell Exhaustion | Chronic Kidney Disease in Long-Term Survivors after Allogeneic Hematopoietic Stem Cell Transplantation: Retrospective Analysis at a Single Institute. | 28822830 |
| Chronic Kidney Diseases | Stem Cell Exhaustion | Conditioning regimen, stem cell source, or the presence of acute/chronic GVHD was not significantly associated with CKD in this study. | 28822830 |
| Sweet Syndrome, Primary Myelofibrosis | Stem Cell Exhaustion | Recurrent Subcutaneous Sweet's Disease in a Myelofibrosis Patient Treated with Ruxolitinib before Allogeneic Stem Cell Transplantation. | 28824063 |
| Treatment related secondary malignancy, Primary Myelofibrosis | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (allo-SCT) has a curative potential for myelofibrosis (MF) patients; however, its association with a high therapy-related mortality (TRM) remains a big obstacle that needs to be overcome. | 28824063 |
| Pregnancy Complications, Infectious, Multiple Myeloma | Stem Cell Exhaustion | Infectious complications in multiple myeloma receiving autologous stem cell transplantation in the past 10 years. | 28825207 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma, Communicable Diseases | Stem Cell Exhaustion | Infection is one of the main causes of early-treatment mortality in multiple myeloma (MM) patients during autologous stem cell transplantation (autoSCT). | 28825207 |
| COL4A2 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | We report a case of cutaneous ICH occurring after allogeneic hematopoietic stem-cell transplantation for a myelodysplastic syndrome in a 56-year-old man. | 28825606 |
| COL4A2 wt Allele, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | This case broadens the spectrum of complications after stem-cell transplantation and demonstrates that cutaneous ICH in the setting of myelodysplastic syndromes may have a nonrelated origin to dysplastic myeloid cells. | 28825606 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Minor histocompatibility antigen (miHA) mismatches have been related to graft-versus-host disease (GVHD) after allogeneic stem cell transplantation, but this association remains controversial due to the lack of consistency in the results obtained by different groups. | 28827064 |
| Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | Polymorphisms of the stem cell marker gene CD133 are associated the clinical outcome in a cohort of Chinese non-small cell lung cancer patients. | 28827262 |
| Parkinson Disease | Stem Cell Exhaustion | To examine the pathogenic role of a-synuclein (aS) in Parkinson's Disease, we have generated induced Pluripotent Stem Cell lines from early onset Parkinson's Disease patients with SNCA A53T and SNCA Triplication mutations, and in this study have differentiated them to PSC-macrophages (pMac), which recapitulate many features of their brain-resident cousins, microglia. | 28827786 |
| Fibrosis Assessment | Stem Cell Exhaustion | Multipotent mesenchymal stem cells in lung fibrosis. | 28827799 |
| Lung diseases | Stem Cell Exhaustion | Stem cells have been identified in the human lung; however, their role in lung disease is not clear. | 28827799 |
| Structure of parenchyma of lung | Stem Cell Exhaustion | We aimed to isolate mesenchymal stem cells (MSC) from human lung tissue and to study their in vitro properties. | 28827799 |
| Gastric Adenocarcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Systemic Inflammation Response Index (SIRI), cancer stem cells and survival of localised gastric adenocarcinoma after curative resection. | 28828692 |
| Malignant neoplasm of stomach, Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells (CSCs) can contribute to gastric cancer progression and recurrence. | 28828692 |
| methyldopa | Stem Cell Exhaustion | Extensive preclinical studies of stem cell replacement therapies for AMD involve the transplantation of stem cell-derived RPE cells into the subretinal space of animal models, in which the subretinal injection technique is applied. | 28829422 |
| Specialty Type - cancer | Stem Cell Exhaustion | We developed a panel of patient-derived mouse orthotopic xenografts (PDOX) for preclinical drug studies by implanting cancer stem cells (CSC) cultured from fresh surgical specimens intracranially into 8-wk-old female athymic nude mice. | 28830577 |
| Prostate carcinoma | Stem Cell Exhaustion | We aimed to investigate the immunohistochemical expression of epithelial-mesenchymal transition (EMT)-related molecules (Twist-1 and E-cadherin) and the stem cell marker EZH2 in prostate cancer and to assess their ability to identify the high-risk patients, in a trial to explore their prognostic implications. | 28832071 |
| Crabs | Stem Cell Exhaustion | Among 623 patients, the triplet group (n=146 [23%]) was younger (65.2 vs 69.8 years) and more likely to have high-risk relapse (67% vs 50%), CRAB symptoms (94.5% vs 81.1%), triplet first-line treatment (75% vs 51%) and frontline stem cell transplant (38% vs 20%) (P<0.001 for all). | 28833305 |
| Meningioma | Stem Cell Exhaustion | We detected c-Kit expression in a minority of the melanocytes as well as stem cell factor and basic fibroblast growth factor in the meningioma cells, suggesting that mechanisms implicated in normal melanocyte migration may be involved. | 28833600 |
| Hemophilia A | Stem Cell Exhaustion | Methods Using fibroblasts from skin biopsies of a previously identified hemophilic patient bearing the F9 c.278-3A>G mutation and his mother, we generated induced pluripotent stem cells (iPSCs). | 28834196 |
| Failure | Stem Cell Exhaustion | Relapse has emerged as the most important cause of treatment failure after allogeneic hematopoietic stem cell transplantation (HSCT). | 28835441 |
| Infection | Stem Cell Exhaustion | Two patients received autologous peripheral blood stem cell transplantation after bortezomib, which led to fatal infections. | 28836002 |
| diabetic | Stem Cell Exhaustion | Periodontal treatment modulates gene expression of endothelial progenitor cells in diabetic patients. | 28836285 |
| diabetic | Stem Cell Exhaustion | This study investigated the effects of periodontal treatment on immuno-inflammatory gene expression of endothelial progenitor cells (EPCs) in diabetic patients. | 28836285 |
| Cryptorchidism | Stem Cell Exhaustion | In nonsyndromic cryptorchidism PLAP-positive undifferentiated spermatogonial stem cells persisted in a significant proportion of nontreated undescended testes and they will be especially sensitive to long-lasting abnormally high temperature that may be the single most important cause facilitating the accumulation of mutations during cell replication and the development of ITGCN to be prevented by orchiopexy. | 28838001 |
| Inflammation, diabetic | Stem Cell Exhaustion | Comparison of Ticagrelor Versus Prasugrel for Inflammation, Vascular Function, and Circulating Endothelial Progenitor Cells in Diabetic Patients With Non-ST-Segment Elevation Acute Coronary Syndrome Requiring Coronary Stenting: A Prospective, Randomized, Crossover Trial. | 28838475 |
| Inflammation | Stem Cell Exhaustion | This study compared adenosine-associated pleiotropic effects of the 2 P2Y12 receptor antagonists on vascular function, systemic inflammation, and circulating endothelial progenitor cells (EPCs). | 28838475 |
| Arterial Stiffness, Inflammation, diabetic, Acute Coronary Syndrome | Stem Cell Exhaustion | (Comparison of Ticagrelor vs. Prasugrel on Inflammation, Arterial Stiffness, Endothelial Function, and Circulating Endothelial Progenitor Cells in Diabetic Patients With Non-ST Elevation Acute Coronary Syndrome [NSTE-ACS] Requiring Coronary Stenting; NCT02487732). | 28838475 |
| Multiple Myeloma | Stem Cell Exhaustion | We assessed the ability of a mass spectrometry-based technique, called monoclonal immunoglobulin rapid accurate mass measurement (miRAMM), to extend the analytical range of M-protein detection in serum samples obtained from myeloma patients in stringent complete response (sCR) post-autologous stem cell transplant (ASCT). | 28841203 |
| Lymphoma, Multiple Myeloma | Stem Cell Exhaustion | Cytomegalovirus reactivation in lymphoma and myeloma patients undergoing autologous peripheral blood stem cell transplantation. | 28843110 |
| Sepsis, Specialty Type - cancer, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Patients with AML had a higher sepsis incidence and higher mortality rates overall, especially in relation to stem-cell transplant recipients and those with other types of cancer. | 28844403 |
| Osteoporosis | Stem Cell Exhaustion | Transcriptional profiling of human femoral mesenchymal stem cells in osteoporosis and its association with adipogenesis. | 28844671 |
| BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 20, Osteoporosis | Stem Cell Exhaustion | Osteoblasts and adipocytes share a common origin, mesenchymal stem cells (MSCs), and their genetic determinants might be important in the relationship between osteoporosis and obesity. | 28844671 |
| Toxic effect | Stem Cell Exhaustion | Impact of Fluid Overload as New Toxicity Category on Hematopoietic Stem Cell Transplantation Outcomes. | 28844946 |
| Aplastic Anemia | Stem Cell Exhaustion | Outcome of Second Transplantation Using Umbilical Cord Blood for Graft Failure after Allogeneic Hematopoietic Stem Cell Transplantation for Aplastic Anemia. | 28844947 |
| Aplastic Anemia | Stem Cell Exhaustion | Graft failure (GF) is the most critical life-threatening complication of allogeneic hematopoietic stem cell transplantation (HSCT) for aplastic anemia, for which a second transplantation is the only effective treatment. | 28844947 |
| Aplastic Anemia | Stem Cell Exhaustion | Although further investigation is needed, umbilical cord blood could be an effective and promising option for stem cell source for urgent second transplantation in patients with aplastic anemia who develop GF after the first HSCT. | 28844947 |
| Neutropenia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | This prospective study included 87 adult hematological patients at the start of febrile neutropenia after intensive chemotherapy for acute myeloid leukemia or after autologous stem cell transplantation. | 28845081 |
| Degenerative disorder | Stem Cell Exhaustion | Induced pluripotent stem cells (iPSCs), which are used to produce transplantable tissues, may particularly benefit older patients, who are more likely to suffer from degenerative diseases. | 28846095 |
| Lymphoma | Stem Cell Exhaustion | Lack of a Prognostic Impact of the MyD88 L265P Mutation for Diffuse Large B Cell Lymphoma Patients Undergoing Autologous Stem Cell Transplantation. | 28847710 |
| Nausea, Chemotherapy-induced Nausea and Vomiting Questionnaire | Stem Cell Exhaustion | Our data indicated that the addition of aprepitant for CINV prophylaxis during HDCT reduced the incidence of severe nausea and might also provide economic benefit in the overall management of HDCT prior to autologous peripheral blood stem cell transplantation. | 28848220 |
| Multiple Myeloma | Stem Cell Exhaustion | Outcomes of maintenance therapy with lenalidomide or bortezomib in multiple myeloma in the setting of early autologous stem cell transplantation. | 28848227 |
| Specialty Type - cancer | Stem Cell Exhaustion | YAP signaling in gastric cancer-derived mesenchymal stem cells is critical for its promoting role in cancer progression. | 28848999 |
| Neoplasms | Stem Cell Exhaustion | Cancer-associated mesenchymal stem cells (MSCs) are critically involved in tumor development and progression. | 28848999 |
| Malignant neoplasm of stomach | Stem Cell Exhaustion | Herein, we reported that the expression of Yes-associated protein 1 (YAP) was higher in gastric cancer derived mesenchymal stem cells (GC-MSCs) than that in bone marrow derived MSCs (BM-MSCs). | 28848999 |
| Chronic Obstructive Airway Disease, Impaired T cell function | Stem Cell Exhaustion | Endothelial progenitor cell dysfunction in acute exacerbation of chronic obstructive pulmonary disease. | 28849108 |
| Chronic Obstructive Airway Disease, Cardiac dysfunction | Stem Cell Exhaustion | Endothelial progenitor cells (EPCs) are decreased in cardiac dysfunction morbidity associated with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). | 28849108 |
| Toxic effect | Stem Cell Exhaustion | We studied early potential treosulfan-related toxicity in 118 patients treated with treosulfan-based conditioning before allogeneic hematopoietic stem-cell transplantation. | 28849374 |
| Amyloidosis | Stem Cell Exhaustion | An observational study was conducted to assess health-related quality of life (HRQoL) in patients treated for AL amyloidosis between 1994 and 2014 with both high dose melphalan and stem cell transplantation (HDM/SCT) or non-SCT chemotherapy regimens. | 28850697 |
| CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology | Stem Cell Exhaustion | In the R/R setting, there was no survival difference between IST and allogeneic stem cell transplant groups, with a trend toward superior OS in the former. | 28850699 |
| Malignant neoplasm of ovary, Specialty Type - cancer | Stem Cell Exhaustion | Aldehyde dehydrogenase-1A1 (ALDH1A1), CD133, CD44, and CD24 have been reported as cancer stem cell markers in ovarian cancers. | 28851663 |
| Stable chronic Graft vs Host Disease | Stem Cell Exhaustion | We conducted ex vivo activation and signaling assays of 30 primary samples from hematopoietic stem cell transplantation patients with and without cGVHD. | 28851699 |
| Neoplasms | Stem Cell Exhaustion | Using paired differentiated and stem cell primary cultures, we investigated the association of SHP2 expression with the tumor stem cell compartment. | 28852935 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | SHP2 regulates proliferation and tumorigenicity of glioma stem cells. | 28852935 |
| Glioblastoma Multiforme Pathway | Stem Cell Exhaustion | Given the importance of SHP2 in developing neural stem cells, and the importance of glioma stem cells (GSCs) in GBM oncogenesis, we explored the functional role of SHP2 in GSCs. | 28852935 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | Pre-transplant PET/CT may be prognostic in diffuse large B-cell lymphoma (DLBCL) patients undergoing autologous stem cell transplantation (ASCT). | 28853617 |
| Hirschsprung Disease, Lymphohistiocytosis, Hemophagocytic | Stem Cell Exhaustion | There have not been any previously reported cases of near total intestinal aganglionosis complicated by concerns for hemophagocytic lymphohistiocytosis and need for both multivisceral organ transplant and hematopoietic stem cell transplant. | 28854959 |
| Lymphohistiocytosis, Hemophagocytic | Stem Cell Exhaustion | He presents a complex challenge creating difficulty with management of whether to proceed with bowel transplant as a result of near-total intestinal aganglionosis or hematopoietic stem cell transplant for treatment of hemophagocytic lymphohistiocytosis. | 28854959 |
| Ischemia | Stem Cell Exhaustion | Circulating GDF15 levels were measured using a multiplex immunoassay in patients with critical limb ischemia and PAD from 2 different patient cohorts that included patients with clinically manifest PAD: the JUVENTAS (Rejuvenating Endothelial Progenitor Cells via Transcutaneous Intra-Arterial Supplementation) trial (n=160, 67 major events; critical limb ischemia) and the Athero-Express Biobank (n=386, 64 major events; PAD). | 28855167 |
| Impaired, Impaired cognition, "Alzheimers Disease | Stem Cell Exhaustion | In this regard, new evidence linking Alzheimer's disease-related pathology and neuronal stem cells suggests that hippocampal neurogenesis impairment is an important factor underlying these cognitive deficits. | 28855626 |
| Specialty Type - cancer, Head and Neck Carcinoma | Stem Cell Exhaustion | The effect of targeted therapy on recruited cancer stem cells in a head and neck carcinoma model. | 28857306 |
| Malignant Head and Neck Neoplasm, Specialty Type - cancer, MMP8 protein, human | Stem Cell Exhaustion | Head and neck cancers (HNC) are known for their repopulation ability driven by cancer stem cells (CSCs). | 28857306 |
| Specialty Type - cancer | Stem Cell Exhaustion | The fate of both cycling and quiescent cancer stem cells is assessed. | 28857306 |
| Specialty Type - cancer | Stem Cell Exhaustion | The Linear Quadratic model is used to simulate radiotherapy, while cellular recruitment and the effects of ATRA on cancer stem cells are modelled based on literature data. | 28857306 |
| BCR gene | Stem Cell Exhaustion | Before consolidation or allogeneic stem cell transplantation (allo-HSCT), negative Flow-MRD was associated with improved survival (p = .019 and .041, respectively) for Ph- ALL patients, but not for Ph+ ALL (p = .111 and .812, respectively). | 28857648 |
| palladium, Parkinson Disease | Stem Cell Exhaustion | Induced pluripotent stem cells (iPS cells) are a promising source for a cell-based therapy to treat Parkinson's disease (PD), in which midbrain dopaminergic neurons progressively degenerate. | 28858313 |
| palladium | Stem Cell Exhaustion | Here we show that human iPS cell-derived dopaminergic progenitor cells survived and functioned as midbrain dopaminergic neurons in a primate model of PD (Macaca fascicularis) treated with the neurotoxin MPTP. | 28858313 |
| Thrombotic Microangiopathies | Stem Cell Exhaustion | Thrombotic Microangiopathy after Allogeneic Stem Cell Transplantation: A Comparison of Eculizumab Therapy and Conventional Therapy. | 28860002 |
| Acute GVH disease | Stem Cell Exhaustion | Soluble Interleukin-7 receptor levels and risk of acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation. | 28863969 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | The composite endpoint graft-versus-host disease (GVHD)-free, relapse-free survival (GRFS) has recently been introduced as a tool to assess the success of allogeneic hematopoietic stem cell transplantation (HSCT) and has been incorporated into recent randomized trials of GVHD prophylaxis by the Blood and Marrow Transplant Clinical Trials Network. | 28864140 |
| GJB2 wt Allele | Stem Cell Exhaustion | In the HID group, 86 patients (54%) received peripheral blood stem cells as the graft source. | 28864140 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Haploidentical Hematopoietic Stem Cell Transplantation for Myelodysplastic Syndrome. | 28865971 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | This study aimed to validate the capability of the Center for International Blood and Marrow Transplant Research (CIBMTR) prognostic scoring system to predict outcomes of patients with myelodysplastic syndromes (MDS) who had undergone HLA-haploidentical related donor hematopoietic stem cell transplantation (haplo-HSCT). | 28865971 |
| Amyloidosis | Stem Cell Exhaustion | High-Dose Melphalan and Stem Cell Transplantation in Patients on Dialysis Due to Immunoglobulin Light-Chain Amyloidosis and Monoclonal Immunoglobulin Deposition Disease. | 28865972 |
| Amyloidosis, Organ Dysfunction Scores | Stem Cell Exhaustion | High-dose melphalan and stem cell transplantation (HDM/SCT) is effective for selected patients with AL amyloidosis, with high rates of complete hematologic response and potential for improved organ dysfunction. | 28865972 |
| SERPINB3 wt Allele, Specialty Type - cancer, Squamous cell carcinoma | Stem Cell Exhaustion | The objective of this study was to explore the prognostic value of cancer stem cell markers, namely CD133, NANOG, and NOTCH1, in early stage oral squamous cell carcinoma (OSCC). | 28866747 |
| Lymphoma | Stem Cell Exhaustion | Prolonged hospitalization, primary refractory disease, performance status and age are prognostic factors for survival in patients with diffuse large B-cell lymphoma and transformed indolent lymphoma undergoing autologous stem cell transplantation. | 28868963 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | In patients with relapsed diffuse large B-cell lymphoma (DLBCL), high-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is standard treatment. | 28868963 |
| Skeletal muscle hypertrophy | Stem Cell Exhaustion | Likewise, aged individuals demonstrated an impaired response to re-loading reflected by attenuated gains in myofibre area, in parallel with smaller increases in satellite cell number despite no age-related differences were observed in factors known to promote skeletal muscle hypertrophy and myogenic stem cell proliferation (IGF-Ea, MGF, MyoD, myogenin, HGF). | 28869034 |
| Carcinogenesis | Stem Cell Exhaustion | The signature regulated signaling pathways including Calcium, MAPK, ErbB, mTOR and cell cycle involved in carcinogenesis from glial progenitor cell to primary GBM. | 28869437 |
| Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Age does not adversely influence outcomes among patients older than 60 years who undergo allogeneic hematopoietic stem cell transplant for AML and myelodysplastic syndrome. | 28869613 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplant (AHSCT) outcomes data of older AML/myelodysplastic syndrome (MDS) patients are limited. | 28869613 |
| Multiple Myeloma | Stem Cell Exhaustion | A phase 1 trial of 90Y-Zevalin radioimmunotherapy with autologous stem cell transplant for multiple myeloma. | 28869617 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | This phase 1 study (clinical trial NCT00477815) was conducted to determine the maximum tolerated dose (MTD) of yttrium-90 ibritumomab tiuxetan (90Y-Zevalin) with high dose melphalan (HDM) therapy in multiple myeloma (MM) patients undergoing autologous stem cell transplantation (ASCT). | 28869617 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | High-dose Thiotepa, Busulfan, Cyclophosphamide, and Autologous Stem Cell Transplantation as Upfront Consolidation for Systemic Non-Hodgkin Lymphoma With Synchronous Central Nervous System Involvement. | 28870642 |
| Liver carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Expression of Cancer Stem Cell-associated DKK1 mRNA Serves as Prognostic Marker for Hepatocellular Carcinoma. | 28870909 |
| Liver carcinoma, Specialty Type - cancer, Hollings Cancer Center | Stem Cell Exhaustion | Cancer stem cells (CSCs) are associated with prognosis of hepatocellular carcinoma (HCC). | 28870909 |
| Neoplasms | Stem Cell Exhaustion | Second neoplasms in adult patients submitted to haematopoietic stem cell transplantation. | 28874263 |
| Neoplasms | Stem Cell Exhaustion | Patients submitted to haematopoietic stem cell transplantation (HSCT) are at increased risk of late complications, such as second neoplasm (SN). | 28874263 |
| Glioblastoma Multiforme Pathway, Behavior | Stem Cell Exhaustion | Although the mechanistic aspects of GJIC have been extensively studied, the role of connexins in the regulation of the malignant behavior of glioma stem cells (GSCs) remains unclear. | 28875331 |
| Drusen, FUNDUS DYSTROPHY, PSEUDOINFLAMMATORY, OF SORSBY, Dopa-Responsive Dystonia, Autosome | Stem Cell Exhaustion | Here, we use human induced pluripotent stem cell-retinal pigment epithelium (hiPSC-RPE) derived from patients with three dominant MDs, Sorsby's fundus dystrophy (SFD), Doyne honeycomb retinal dystrophy/malattia Leventinese (DHRD), and autosomal dominant radial drusen (ADRD), and demonstrate that dysfunction of RPE cells alone is sufficient for the initiation of sub-RPE lipoproteinaceous deposit (drusen) formation and extracellular matrix (ECM) alteration in these diseases. | 28878022 |
| Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Filgrastim is usually combined with chemotherapy to mobilize hematopoietic progenitor cells in non-Hodgkin lymphoma (NHL) patients. | 28879595 |
| Heart failure, Myocardial Ischemia | Stem Cell Exhaustion | The present first-in-human clinical trial evaluated the safety and feasibility of a newly developed and cryopreserved Cardiology Stem Cell Centre adipose-derived stromal cell (CSCC_ASC) product from healthy donors for intramyocardial injection in ten patients with ischemic heart disease and ischemic heart failure (IHF). | 28880460 |
| Shock, Cardiogenic | Stem Cell Exhaustion | A dual therapy of off-pump temporary left ventricular extracorporeal device and amniotic stem cell for cardiogenic shock. | 28882138 |
| Shock, Cardiogenic | Stem Cell Exhaustion | Temporary mechanical circulatory support device without sternotomy has been highly advocated for severe cardiogenic shock patient but little is known when coupled with amniotic stem cell therapy. | 28882138 |
| Shock, Cardiogenic | Stem Cell Exhaustion | This case reports the first dual therapy of temporary left ventricular extracorporeal device CentriMag with distal banding technique and human amniotic stem cell injection for treating a severe refractory cardiogenic shock of an 68-year-old female patient. | 28882138 |
| Myocardial Reperfusion | Stem Cell Exhaustion | The concomitant use of the temporary minimally-invasive off-pump CentriMag placement and stem cell therapy not only provided an alternative to cardiopulmonary bypass and full-median sternotomy procedures but may have also synergistically enhanced myocardial reperfusion and regeneration. | 28882138 |
| Acute leukemia | Stem Cell Exhaustion | Human leukocyte antigen-E mismatch is associated with better hematopoietic stem cell transplantation outcome in acute leukemia patients. | 28883078 |
| Malignant lymphoma of testis | Stem Cell Exhaustion | High-dose chemotherapy with autologous stem cell transplantation following systemic chemotherapy, prophylactic intrathecal methotrexate, and radiotherapy prevents relapse and improves the outcome of advanced stage primary testicular lymphoma even with cardiac involvement. | 28883219 |
| ACAA1 gene | Stem Cell Exhaustion | We herein report an extremely rare case of advanced stage PTL with cardiac involvement, treated by high-dose chemotherapy with autologous stem cell transplantation (HDT-ASCT) followed by systemic chemotherapy, prophylactic intrathecal methotrexate (IT-MTX), and radiotherapy. | 28883219 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer may arise from dedifferentiation of mature cells or maturation-arrested stem cells. | 28883415 |
| Specialty Type - cancer | Stem Cell Exhaustion | The resected specimens were analyzed for associations with clinicopathological data, including DCLK1 expression, epithelial mesenchymal transition (EMT) marker expression, and cancer stem cell (CSC) marker expression. | 28883702 |
| TNF protein, human | Stem Cell Exhaustion | They also displayed higher expressions of embryonic stem cell marker OCT3/4 and osteogenic factors Wnt3a, b-catenin, and microRNA-29a (miR-29a), concomitant with lower expressions of joint-deleterious factors HDAC4, TGF-b1, IL-1b, TNF-a, and MMP3, in comparison with those of BMMSCs. | 28884332 |
| leukemia | Stem Cell Exhaustion | Severe Mucha-Habermann-Like Ulceronecrotic Skin Disease in T-Cell Acute Lymphoblastic Leukemia Responsive to Basiliximab and Stem Cell Transplant. | 28884915 |
| Leukemia, Myelomonocytic, Chronic, Myeloproliferation, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | Chronic myelomonocytic leukemia (CMML) is a hematopoietic stem cell neoplasm exhibiting both myelodysplastic and myeloproliferative features. | 28885734 |
| Anemia, Sickle Cell, Renal carnitine transport defect | Stem Cell Exhaustion | Novel curative therapies using genetic transfer of normal globin-producing genes into autologous hematopoietic stem cells (HSCs) are in clinical trials for patients with sickle cell disease (SCD). | 28887325 |
| Pulmonary Complication | Stem Cell Exhaustion | Late-onset non-infectious pulmonary complications (LONIPCs) contribute to higher morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 28888028 |
| Specialty Type - cancer | Stem Cell Exhaustion | The rate of CD44v9-positive cases, a cancer stem cell marker, was assessed in C-IV/C-V samples with immunohistochemical staining. | 28890117 |
| Specialty Type - cancer, Malignant neoplasm of stomach, Neoplasms | Stem Cell Exhaustion | These data suggest that cancer cells, including cancer stem cells, in early gastric cancers are easily detached via contact with the tumor surface. | 28890117 |
| Myopathy, Impaired T cell function | Stem Cell Exhaustion | In many muscle disorders, the repeated cycles of damage and repair lead to stem cell dysfunction. | 28890163 |
| MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Validation of the revised IPSS at transplant in patients with myelodysplastic syndrome/transformed acute myelogenous leukemia receiving allogeneic stem cell transplantation: a retrospective analysis of the EBMT chronic malignancies working party. | 28892084 |
| Corneal Endothelial Cell Loss | Stem Cell Exhaustion | Circulating endothelial cell count: a reliable marker of endothelial damage in patients undergoing hematopoietic stem cell transplantation. | 28892085 |
| Multiple Myeloma | Stem Cell Exhaustion | Allogeneic stem cell transplantation and subsequent treatments as a comprehensive strategy for long-term survival of multiple myeloma patients. | 28892086 |
| Crohn Disease | Stem Cell Exhaustion | Living with Crohn's disease: an exploratory cross-sectional qualitative study into decision-making and expectations in relation to autologous haematopoietic stem cell treatment (the DECIDES study). | 28893742 |
| Crohn Disease | Stem Cell Exhaustion | Decision-making and expectations of people with severe Crohn's disease in relation to autologous haematopoietic stem cell treatment is a complex process influenced by participants' histories of battling with their condition, a frequent willingness to consider novel treatment options despite potential risks and, in some cases, a raised level of expectation about the benefits of trial participation. | 28893742 |
| Malignant Neoplasms, Carcinoma of larynx | Stem Cell Exhaustion | NANOG is a master regulator of embryonic stem cell pluripotency, found to be frequently aberrantly expressed in a variety of cancers, including laryngeal carcinomas. | 28894270 |
| Multiple Myeloma | Stem Cell Exhaustion | Inpatient vs outpatient autologous hematopoietic stem cell transplantation for multiple myeloma. | 28895206 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | High-dose chemotherapy and autologous hematopoietic stem cell transplantation (auto-HCT) are commonly performed for multiple myeloma (MM) patients and may be as safe in the outpatient setting as in the inpatient setting. | 28895206 |
| Hodgkin Disease | Stem Cell Exhaustion | Prognostic Model to Predict Post-Autologous Stem-Cell Transplantation Outcomes in Classical Hodgkin Lymphoma. | 28898161 |
| Hodgkin Disease | Stem Cell Exhaustion | Purpose Our aim was to capture the biology of classical Hodgkin lymphoma (cHL) at the time of relapse and discover novel and robust biomarkers that predict outcomes after autologous stem-cell transplantation (ASCT). | 28898161 |
| Specialty Type - cancer | Stem Cell Exhaustion | After retrospective analysis of the cancer samples of patients who received esophagectomy, we found the relevance between ratio of either ALDH1 or CD133-positive cancer stem cells and 2-year recurrence. | 28902370 |
| Esophageal carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Higher ratios of cancer stem cells indicated later clinical stages, and Wnt signaling activation was more frequent in later esophageal carcinoma. | 28902370 |
| Esophageal Neoplasms | Stem Cell Exhaustion | Further in bench studies, we explored the suppressive roles and the mechanisms involved in Let-7 on self-renewal in ECA-109 and ECA-9706 esophageal cancer stem cells. | 28902370 |
| Specialty Type - cancer | Stem Cell Exhaustion | Isolated cancer stem cells naturally divide symmetrically and are therapy resistant. | 28902370 |
| Specialty Type - cancer | Stem Cell Exhaustion | Therapy of fluorouracil and docetaxel both enriched the stem cells, proving the resistant characteristics of cancer stem cells. | 28902370 |
| Specialty Type - cancer, Esophageal Neoplasms | Stem Cell Exhaustion | These results identified the crucial participation of stem cells in esophageal cancer occurrence and progression as the potent indicator, and also indicate the potential powerful agent of Let-7 nano-particles in treatment of cancer. | 28902370 |
| Drug-induced immune hemolytic anemia, Decreased platelet count, Drug-induced | Stem Cell Exhaustion | Drug-induced immune hemolytic anemia (DIIHA) and drug-induced immune thrombocytopenia (DIIT) are rare but dangerous complications of pharmacotherapy that may be underrecognized in hematopoietic stem cell transplant (HSCT) patients due to overlap of signs and symptoms with those of more common disease processes. | 28905389 |
| Specialty Type - cancer, Ovarian Serous Tumor | Stem Cell Exhaustion | Cancer Stem Cell-Related Marker NANOG Expression in Ovarian Serous Tumors: A Clinicopathological Study of 159 Cases. | 28906309 |
| Specialty Type - cancer, Ovarian Serous Adenocarcinoma, Ovarian Serous Tumor | Stem Cell Exhaustion | The objectives of this study were to assess cancer stem cell-related marker NANOG expression in ovarian serous tumors and to evaluate its prognostic significance in relation to ovarian serous carcinoma. | 28906309 |
| Lymphoma, Non-Hodgkin, Familial, Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Fludarabine/busulfan-based conditioning regimens are widely used to perform allogeneic stem-cell transplantation (allo-SCT) in high-risk non-Hodgkin lymphoma (NHL) patients. | 28911060 |
| methyldopa | Stem Cell Exhaustion | We have derived and characterized induced pluripotent stem cell (iPSC) lines from two subjects without AMD and low-risk genotype and two patients with advanced AMD and high-risk genotype and generated RPE cells that show local secretion of several proteins involved in the complement pathway including factor H, factor I, and factor H-like protein 1. | 28913923 |
| Ischemic stroke | Stem Cell Exhaustion | Age of donor of human mesenchymal stem cells affects structural and functional recovery after cell therapy following ischaemic stroke. | 28914133 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Allogeneic stem cell transplantation with HLA-matched donors is increasingly used for older patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). | 28918304 |
| Multiple Myeloma | Stem Cell Exhaustion | Symptom experience of multiple myeloma (syMMex) patients treated with autologous stem cell transplantation following high-dose melphalan: a descriptive longitudinal study. | 28918604 |
| Coronary Arteriosclerosis, Acute myocardial infarction | Stem Cell Exhaustion | Mobilization of endothelial progenitor cells (EPCs) into circulation from bone marrow in patients with acute myocardial infarction has strong scientific evidence; less is known about EPC mobilization in patients with stable coronary artery disease (CAD). | 28918896 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Resident platelet-derived growth factor receptor a-positive mesenchymal progenitor cells contributed to ectopic adipogenesis in vastus medialis muscles of OA patients. | 28919112 |
| Neutropenia | Stem Cell Exhaustion | Diagnostic value of sTREM-1, IL-8, PCT, and CRP in febrile neutropenia after autologous stem cell transplantation. | 28920169 |
| Infection, Febrile Neutropenia, Pregnancy Complications, Infectious | Stem Cell Exhaustion | Infections and infectious complications are the major cause of morbidity and mortality in febrile neutropenic patients after autologous stem cell transplantation. | 28920169 |
| Neutropenia, Febrile Neutropenia | Stem Cell Exhaustion | Here, to assess the utility of PCT, CRP, IL-8, and sTREM-1 in febrile neutropenia, 44 patients presenting with febrile neutropenia after autologous stem cell transplantation were recruited in a single-center prospective pilot study. | 28920169 |
| Malignant neoplasm of lung | Stem Cell Exhaustion | Maximized nanodrug-loaded mesenchymal stem cells by a dual drug-loaded mode for the systemic treatment of metastatic lung cancer. | 28920712 |
| Corneal Neovascularization | Stem Cell Exhaustion | Thus, we evaluated corneal neovascularization in patients with limbal stem cell deficiency using optical coherence tomography angiography (OCTA). | 28922332 |
| Cardiomyopathies | Stem Cell Exhaustion | Dose Comparison Study of Allogeneic Mesenchymal Stem Cells in Patients With Ischemic Cardiomyopathy (The TRIDENT Study). | 28923793 |
| Ischemic cardiomyopathy | Stem Cell Exhaustion | To compare the safety and efficacy of 2 doses of allogeneic bone marrow-derived human mesenchymal stem cells identically delivered in patients with ischemic cardiomyopathy. | 28923793 |
| Ischemic cardiomyopathy | Stem Cell Exhaustion | Thirty patients with ischemic cardiomyopathy received in a blinded manner either 20 million (n=15) or 100 million (n=15) allogeneic human mesenchymal stem cells via transendocardial injection (0.5 cc per injection x 10 injections per patient). | 28923793 |
| Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Chronic graft-versus-host disease (cGVHD) is a serious complication of allogeneic stem cell transplantation with few effective options available after failure of corticosteroids. | 28924018 |
| Infection | Stem Cell Exhaustion | Prospective evaluation of the SeptiFAST multiplex real-time PCR assay for surveillance and diagnosis of infections in haematological patients after allogeneic stem cell transplantation compared to routine microbiological assays and an in-house real-time PCR method. | 28925082 |
| Parkinson Disease | Stem Cell Exhaustion | Establishment of an induced pluripotent stem cell line ZZUi003-A from a 65-year-old male with sporadic Parkinson's disease. | 28925360 |
| Diabetes Mellitus, Non-Insulin-Dependent | Stem Cell Exhaustion | Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 13 (MODY13) with a the potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) mutation. | 28925365 |
| Study Day of Morphology Assessment | Stem Cell Exhaustion | We generated induced pluripotent stem cells (iPSCs) from a patient with KCNJ11p.Glu227Lys mutation who developed MODY at 13years old. | 28925365 |
| Marfan Syndrome | Stem Cell Exhaustion | A Marfan syndrome human induced pluripotent stem cell line with a heterozygous FBN1 c.4082G>A mutation, ISMMSi002-B, for disease modeling. | 28925368 |
| Brain Injuries, Seizures | Stem Cell Exhaustion | Nestin is expressed in immature neuroepithelial and progenitor cell types and transiently upregulated in proliferative neuroglial cells responding to acute brain injury, including following seizures. | 28925561 |
| Specialty Type - cancer | Stem Cell Exhaustion | Mesenchymal stem cells (MSCs) display pleiotropic functions, which include secretion of soluble factors with immunosuppressive activity implicated in cancer progression. | 28930684 |
| Malignant Neoplasms | Stem Cell Exhaustion | Patients receiving hematopoietic stem cell transplants (HSCT) 29/60 (48%) or with a hematologic malignancy 17/60 (28%) accounted for the majority of DEC cases. | 28931467 |
| Specialty Type - cancer | Stem Cell Exhaustion | BMI-1 plays a key role in biology of stem cells including cancer stem cells by regulation of their self-renewal and differentiation. | 28931748 |
| Specialty Type - cancer | Stem Cell Exhaustion | Taking into account significant role of BMI1 in tumorigenesis, especially associated with cancer stem cells, it seems that this gene may be a promising target of anticancer therapies. | 28931748 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | This study describes short-term and long-term healthcare resource utilization (HRU) and costs following an allogeneic hematopoietic stem cell transplant (HSCT) in adult patients with diffuse large B-cell lymphoma (DLBCL) in a real-world setting. | 28933643 |
| Chronic graft-versus-host disease | Stem Cell Exhaustion | Characteristics and risk of chronic graft-versus-host disease of liver in allogeneic hematopoietic stem cell transplant recipients. | 28934311 |
| Graft-vs-Host Disease, Stable chronic Graft vs Host Disease | Stem Cell Exhaustion | Chronic graft-versus-host-disease (cGvHD) is a serious complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). | 28934311 |
| Chronic graft-versus-host disease | Stem Cell Exhaustion | Because all donors received the identical filgrastim dosing schedule, this study allowed for a controlled evaluation of the impact of stem cell source on development of chronic graft-versus-host disease. | 28935847 |
| Transplantation | Stem Cell Exhaustion | Nutritional Status of Hematological Patients before Hematopoietic Stem Cell Transplantation and in Early Posttransplantation Period. | 28937794 |
| Specialty Type - cancer | Stem Cell Exhaustion | Aldehyde dehydrogenase 1 (ALDH1) is associated with tumorigenesis, and shown to identify cancer stem cells (CSC)-like cells. | 28939082 |
| Adult Glioblastoma | Stem Cell Exhaustion | Purpose: CD90 (Thy-1) is a glycophosphatidylinositol-anchored glycoprotein considered as a surrogate marker for a variety of stem cells, including glioblastoma (GBM) stem cells (GSC). | 28939749 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | Survival after stem-cell transplant in pediatric and young-adult patients with relapsed and refractory B-cell acute lymphoblastic leukemia. | 28945102 |
| Acute lymphocytic leukemia, BCR gene | Stem Cell Exhaustion | Allogeneic stem-cell transplant (allo-SCT) is the standard of care for pediatric patients with acute lymphoblastic leukemia (ALL) who relapse after frontline chemotherapy; however, for patients who relapse after allo-SCT, outcomes are very poor. | 28945102 |
| herpesvirus 3, human | Stem Cell Exhaustion | Herpes zoster incidence and cost in patients receiving autologous hematopoietic stem-cell transplant. | 28945107 |
| herpesvirus 3, human | Stem Cell Exhaustion | Among patients receiving autologous hematopoietic stem cell transplant (Auto-HSCT), this study estimated the incidence of herpes zoster (HZ), compared healthcare costs among patients with and without HZ, and evaluated antiviral prophylaxis (AP) use. | 28945107 |
| Specialty Type - cancer, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Cancer stem cells (CSCs) are a subpopulation of tumour cells capable of self-renewal and differentiation, likely responsible for the initiation, recurrence, metastasis and chemo/radio-resistance. | 28946555 |
| Decreased platelet count | Stem Cell Exhaustion | Impaired Function of Bone Marrow Mesenchymal Stem Cells from Immune Thrombocytopenia Patients in Inducing Regulatory Dendritic Cell Differentiation Through the Notch-1/Jagged-1 Signaling Pathway. | 28946811 |
| Hodgkin Disease | Stem Cell Exhaustion | Brentuximab vedotin in patients with relapsed or refractory Hodgkin lymphoma who are Ineligible for autologous stem cell transplant: A Germany and United Kingdom retrospective study. | 28949403 |
| Hodgkin Disease | Stem Cell Exhaustion | Brentuximab vedotin (BV) is an anti-CD30 antibody-drug conjugate licensed for the treatment of relapsed/refractory Hodgkin lymphoma (rrHL) following autologous stem cell transplant (ASCT) or at least two prior therapies when ASCT or multiagent chemotherapy is not an option. | 28949403 |
| Bacterial Infections | Stem Cell Exhaustion | Purpose Allogeneic hematopoietic cell transplant recipients undergo myelosuppressive chemotherapy to allow engraftment of stem cells and are at particularly high risk for bacterial infections and adverse outcomes. | 28950805 |
| Empyema, Pleural, Lymphoma, Nocardia farcinica | Stem Cell Exhaustion | An unusual case of pleural empyema related to Nocardia farcinica and Ureaplasma urealyticum, occurring after autologous haematopoietic stem cell transplantation in a 30-year-old patient with lymphoma, is reported. | 28951103 |
| Toxic effect | Stem Cell Exhaustion | Impact of Toxicity on Survival for Older Adult Patients after CD34+ Selected Allogeneic Hematopoietic Stem Cell Transplantation. | 28951193 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Ex vivo CD34+ selection before allogeneic hematopoietic stem cell transplantation (allo-HCT) reduces graft-versus-host disease without increasing relapse but usually requires myeloablative conditioning. | 28951193 |
| Malignant neoplasm of lung | Stem Cell Exhaustion | In the present study, we successfully generated lung cancer stem cell (CSC)-like cells by introducing a small set of transcription factors into a lung cancer cell line. | 28951614 |
| Malignant neoplasm of lung, Specialty Type - cancer | Stem Cell Exhaustion | Interleukin-6 blockade attenuates lung cancer tissue construction integrated by cancer stem cells. | 28951614 |
| Malignant neoplasm of lung | Stem Cell Exhaustion | In addition to properties that are conventionally referred to as CSC properties, the lung induced CSCs exhibited the ability to form lung cancer-like tissues in vitro with vascular cells and mesenchymal stem cells, which showed structures and immunohistological patterns that were similar to human lung cancer tissues. | 28951614 |
| Malignant neoplasm of lung | Stem Cell Exhaustion | We found that interleukin-6 (IL-6), which was expressed in the lung induced CSCs, facilitates the formation of lung cancer organoids via the conversion of mesenchymal stem cells into alpha-smooth muscle actin (aSMA)-positive cells. | 28951614 |
| Acute leukemia | Stem Cell Exhaustion | Patients admitted to the Haematology department during 7 months, and fulfilled inclusion criteria were divided into 4 groups: Group 1, patients with acute leukaemia; Group 2, patients after autologous stem cell transplantation (SCT); Group 3, patients after allogeneic SCT; and Group 4, patients given platelet transfusion prior to intervention. | 28952164 |
| Lymphoma | Stem Cell Exhaustion | Rituximab after Autologous Stem-Cell Transplantation in Mantle-Cell Lymphoma. | 28953447 |
| Neoplasms | Stem Cell Exhaustion | A First-in-Human Phase I Study of the Anticancer Stem Cell Agent Ipafricept (OMP-54F28), a Decoy Receptor for Wnt Ligands, in Patients with Advanced Solid Tumors. | 28954784 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Purpose: Wnt signaling is implicated in tumor cell dedifferentiation and cancer stem cell function. | 28954784 |
| Chronic disease, Paroxysmal nocturnal hemoglobinuria, Hemoglobinuria, CTCAE 3.0 | Stem Cell Exhaustion | Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hematopoietic stem cell disorder that must be correctly diagnose because it is a chronic disease with a real impact on the quality of life and the survival of the patients. | 28958970 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Clinical impact of colonization with multidrug-resistant organisms on outcome after allogeneic stem cell transplantation in patients with acute myeloid leukemia. | 28960264 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment option for patients with acute myeloid leukemia (AML). | 28960264 |
| Fulfill, Adult Glioblastoma, Neoplasms | Stem Cell Exhaustion | In this study we investigated ALK, ROS1, and MET status in nine glioblastoma stem cell lines and tumors from which they arise. | 28960893 |
| Adult Glioblastoma | Stem Cell Exhaustion | Crizotinib targets in glioblastoma stem cells. | 28960893 |
| Adult Glioblastoma, Neoplasms | Stem Cell Exhaustion | Glioblastoma stem cells (GSCs) are believed to be involved in the mechanisms of tumor resistance, therapeutic failures, and recurrences after conventional glioblastoma therapy. | 28960893 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Serum levels, safety and tolerability of new formulation SUBA-itraconazole prophylaxis in patients with haematological malignancy or undergoing allogeneic stem cell transplantation. | 28961894 |
| Hyalinosis, Systemic, Osteoporotic Fractures | Stem Cell Exhaustion | A unique heterologous fibrin sealant (HFS) as a candidate biological scaffold for mesenchymal stem cells in osteoporotic rats. | 28962655 |
| Osteoporotic Fractures | Stem Cell Exhaustion | The injection of mesenchymal stem cells (MSCs) directly into the bone of osteoporotic (OP) patients for rapid recovery has been studied worldwide. | 28962655 |
| Myeloid neoplasm | Stem Cell Exhaustion | Bone marrow mesenchymal stromal cells (MSCs), which support proliferation and differentiation of hematopoietic stem cells, may play a crucial role in the pathogenesis of myeloid neoplasms. | 28964959 |
| Thrombocytopenic purpura | Stem Cell Exhaustion | Effect of thrombopoietin receptor agonists on leukocyte and haematopoietic stem and progenitor cells in the peripheral blood of patients with immune thrombocytopenic purpura. | 28965224 |
| Primary Myelofibrosis, Leukocytosis | Stem Cell Exhaustion | Our results indicate that TPO-RAs may also mobilize haematopoietic stem and progenitor cells (HSPCs) in peripheral blood and the occurrence of such relative leukocytosis may signalize an early symptom of myelofibrosis due to treatment with TPO-RAs. | 28965224 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Efficacy of idelalisib as bridge to allogeneic stem cell transplant in relapsed follicular lymphoma: a case report. | 28967090 |
| Lymphoma, Follicular | Stem Cell Exhaustion | We describe the case of a 39-year-old patient with a diagnosis of grade 3a FL and a Follicular Lymphoma International Prognostic Index score of 2, who underwent several lines of therapy (including autologous stem cell transplant) with transient responses or no response at all. | 28967090 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | Are CD44+/CD24- cells the assumed cancer stem cells in breast cancer? | 28967636 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Identification and characterization of the population of cancer stem cells (CSC) depends on several cellular markers, which combination is specific for the phenotype of CSC in the corresponding tumor. | 28967636 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | To search for additional molecular-biological markers of cancer stem cell (CSC) involved in the development of intra-tumor heterogeneity for the detection of features of the breast cancer (BC) pathogenesis. | 28967645 |
| Malignant Neoplasms | Stem Cell Exhaustion | Cells of high-grade malignancy (HGM), MDA-MB-231 and MDA-MB-468 are characterized by high expression of stem cell markers compared to the cells of low-grade malignancy (LGM), T47D and MCF-7: CD44 levels in T47D and MCF-7 cells were in range of 72-79 points, which is significantly lower than in HGM cells (p < 0.05). | 28967645 |
| Bone Marrow Transplantation, Nodular Lymphocyte Predominant Hodgkin Lymphoma | Stem Cell Exhaustion | High dose chemotherapy and autologous stem cell transplantation in nodular lymphocyte-predominant Hodgkin lymphoma: A retrospective study by the European society for blood and marrow transplantation-lymphoma working party. | 28971503 |
| Hodgkin Disease, Nodular Lymphocyte Predominant Hodgkin Lymphoma | Stem Cell Exhaustion | Whilst autologous stem cell transplantation (auto-SCT) is considered standard of care for relapsed/refractory classical Hodgkin lymphoma, the role of auto-SCT in nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is not well defined due to limited data. | 28971503 |
| Leukemia, Myelocytic, Acute, Acute leukemia | Stem Cell Exhaustion | Relatively favorable outcome after allogeneic stem cell transplantation for BCR-ABL1-positive AML: A survey from the acute leukemia working party of the European Society for blood and marrow transplantation (EBMT). | 28971504 |
| Acute myeloid leukemia with BCR-ABL1, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The aim of the study was to assess the role of allogeneic stem cell transplantation (SCT) in patients diagnosed with BCR-ABL1-positive acute myeloid leukemia (AML). | 28971504 |
| Acute leukemia | Stem Cell Exhaustion | Mixed phenotype acute leukemia: outcomes with allogeneic stem cell transplantation. | 28971902 |
| leukemia, Acute leukemia | Stem Cell Exhaustion | In this study, we investigated 519 patients with mixed phenotype acute leukemia in first complete remission who underwent allogeneic hematopoietic stem cell transplantation between 2000 and 2014, and who were reported to the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT). | 28971902 |
| Acute leukemia | Stem Cell Exhaustion | Our study suggests that mixed phenotype acute leukemia is potentially sensitive to graft-versus-leukemia and thus can benefit from allogeneic hematopoietic stem cell transplantation with a potential for cure. | 28971902 |
| Toxic effect | Stem Cell Exhaustion | Nineteen CP patients, discontinued due to resistance (n = 13), toxicity (n = 5) and to pursue stem cell transplantation (n = 1). | 28972430 |
| Hyperplasia | Stem Cell Exhaustion | The aim of our study was to explore the age-related specificities of endometrial proliferative / stem cell index distribution under normal and hyperplasia conditions. | 28972492 |
| Endometrial Hyperplasia | Stem Cell Exhaustion | In the 2nd study group labeled as "endometrial hyperplasia", the proliferative/stem cell index markedly increases and ranges within the interval 15-23. | 28972492 |
| Endometrial Hyperplasia | Stem Cell Exhaustion | It was found that proliferative/stem cell index in the 1st study group labeled as "Norm" progressively decreases with aging, while in the 2nd study group labeled as "Endometrial Hyperplasia" it behaves opposite and increases with age. | 28972492 |
| Endometrial Hyperplasia | Stem Cell Exhaustion | Moreover, it must be noted that proliferative/stem cell index in endometrial hyperplasia cases with regard to norm increases significantly, namely in the subgroups 1.1/1.2 (which is reproductive age) it increases 1.5 times, and in the subgroups 1.2/2.2 (which is menopause age) it increases 2.5 times, while in the subgroups 1.3/2.3 (which is post-menopause age) it increases 18.5 times. | 28972492 |
| Endometrial Hyperplasia | Stem Cell Exhaustion | The high attention should be given to the fact that the mean average value of proliferative/stem cell index in endometrial hyperplasia most markedly differs from the norm in post-menopause period. | 28972492 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | The efficacy of conventional chemotherapy and allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been controversial as post-remission therapies for adult Philadelphia chromosome-negative acute lymphoblastic leukemia patients. | 28973362 |
| Vascular Diseases | Stem Cell Exhaustion | Lower levels of circulating progenitor cells (PCs) reflect impaired endogenous regenerative capacity and are associated with aging, vascular disease, and poor outcomes. | 28974500 |
| Heart failure, Heart Diseases | Stem Cell Exhaustion | Safety and Efficacy of the Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Patients With Heart Failure: A Phase 1/2 Randomized Controlled Trial (RIMECARD Trial [Randomized Clinical Trial of Intravenous Infusion Umbilical Cord Mesenchymal Stem Cells on Cardiopathy]). | 28974553 |
| Cardiovascular Diseases | Stem Cell Exhaustion | Umbilical cord-derived mesenchymal stem cells (UC-MSC) are easily accessible and expanded in vitro, possess distinct properties, and improve myocardial remodeling and function in experimental models of cardiovascular disease. | 28974553 |
| Heart failure | Stem Cell Exhaustion | Although bone marrow-derived mesenchymal stem cells have been previously assessed for their therapeutic potential in individuals with heart failure and reduced ejection fraction, no clinical trial has evaluated intravenous infusion of UC-MSCs in these patients. | 28974553 |
| Seizures, Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | A 61-year-old man with relapsing chronic lymphocytic leukaemia, status post allogeneic stem cell transplant and multiple chemotherapy regimens presented to the emergency room after suffering a grand mal seizure. | 28978601 |
| Heart failure | Stem Cell Exhaustion | Autologous cardiac progenitor cell (CPC) therapy is a promising approach for treatment of heart failure (HF). | 28980705 |
| Heart failure | Stem Cell Exhaustion | Autologous cardiac progenitor cell therapy is a promising alternative approach to current inefficient therapies for heart failure (HF). | 28980705 |
| Epstein-Barr virus | Stem Cell Exhaustion | NK/T-LAHS patients who underwent allogeneic hematopoietic stem cell transplantation (Allo-HSCT) (p = 0.000), exhibited peripheral blood Epstein-Barr virus (EBV)-positivity (p = 0.004), and achieved overall response (OR) remission after initial induction therapy (p = 0.007) had statistical significance. | 28982299 |
| Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | Association Between Endothelial Progenitor Cells and Treatment Response in Non-Squamous Non-small Cell Lung Cancer Treated with Bevacizumab. | 28982871 |
| Non-Small Cell Lung Carcinoma | Stem Cell Exhaustion | To investigate the association between the number of circulating endothelial progenitor cells (EPCs) in non-squamous non-small cell lung cancer (NSCLC) and disease outcome, in combination chemotherapy with and without bevacizumab. | 28982871 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Cancer stem cells (CSC) plays an important role in various kinds of cancers. | 28982889 |
| Acute lymphocytic leukemia, BCR gene | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (HSCT) with the conventional cyclophosphamide and total body irradiation (CY/TBI) regimen is an essential therapeutic strategy for acute lymphoblastic leukemia (ALL) in adults. | 28983949 |
| Hepatic Veno-Occlusive Disease, Lung Injury | Stem Cell Exhaustion | Hepatic Sinusoidal-obstruction Syndrome and Busulfan-induced Lung Injury in a Post-autologous Stem Cell Transplant Recipient. | 28984258 |
| Central neuroblastoma | Stem Cell Exhaustion | We illustrate the clinical and autopsy finings in a 2 1/2 -year-old boy who received autologous stem-cell transplantation following resection of stage IV neuroblastoma. | 28984258 |
| Esophageal carcinoma, Concomitant Medication Submission Domain | Stem Cell Exhaustion | We analyzed: (i) the peritumoral adipose tissue of rats following the induction of esophageal carcinogenesis; (ii) the peritumoral and distal (omental) adipose tissue of patients affected by EAC; (iii) adipose-derived stem cells (ADSC) isolated from healthy patients and treated with conditioned medium (CM), collected from tumoral and adipose tissue of patients with EAC. | 28985034 |
| Kidney Failure, Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Autologous stem cell transplantation (ASCT) reverses kidney failure in one-third of multiple myeloma (MM) patients, which may lead to blood pressure (BP) improvement. | 28987247 |
| Multiple Myeloma | Stem Cell Exhaustion | Before the introduction of "new drugs," we designed a trial in which 162 newly diagnosed myeloma patients were biologically randomized to receive either an autologous stem cell transplant (auto-SCT) followed by a nonmyeloablative allogeneic stem cell transplant (allo-SCT) or a double auto-SCT. | 28987930 |
| Aplastic Anemia | Stem Cell Exhaustion | Fludarabine-based reduced intensity regimen for matched related donor hematopoietic stem cell transplantation in acquired severe aplastic anemia. | 28988743 |
| Aplastic Anemia | Stem Cell Exhaustion | Different conditioning regimens have been evaluated in matched-related donor allogeneic hematopoietic stem cell transplantation (allo-HSCT) for acquired severe aplastic anemia (SAA) with varying results. | 28988743 |
| Specialty Type - cancer, Endometrial Endometrioid Adenocarcinoma | Stem Cell Exhaustion | Association between Morphological Patterns of Myometrial Invasion and Cancer Stem Cell Markers in Endometrial Endometrioid Carcinoma. | 28990139 |
| Specialty Type - cancer | Stem Cell Exhaustion | The present study investigated the association between MI patterns, cancer stem cell (CSC) phenotypes, and their clinicopathological significance in EEC. | 28990139 |
| Bacteremia | Stem Cell Exhaustion | Incidence, Risk Factors and Outcome of Pre-engraftment Gram-Negative Bacteremia After Allogeneic and Autologous Hematopoietic Stem Cell Transplantation: An Italian Prospective Multicenter Survey. | 29020286 |
| Bacteremia, Cessation of life | Stem Cell Exhaustion | Gram-negative bacteremia (GNB) is a major cause of illness and death after hematopoietic stem cell transplantation (HSCT), and updated epidemiological investigation is advisable. | 29020286 |
| Bacteremia | Stem Cell Exhaustion | Antimicrobial Resistance in Gram-Negative Rods Causing Bacteremia in Hematopoietic Stem Cell Transplant Recipients: Intercontinental Prospective Study of the Infectious Diseases Working Party of the European Bone Marrow Transplantation Group. | 29020364 |
| Specialty Type - cancer | Stem Cell Exhaustion | The meeting covered a plethora of rapidly evolving approaches and areas, such as organoid cultures modeling tissues and organs; stem cell-specific metabolites revealing new signaling pathways; single-cell technologies discovering new cell types and exploring stem cell niche interactions; novel methods studying stem cells in aging and cancer; lineage-tracing experiments exploring cell plasticity of tissues before and after injury; epigenetic studies illuminating cell reprogramming; new protocols improving cells for regenerative purposes; and several other timely and exciting topics. | 29020612 |
| Antilymphocyte Serum | Stem Cell Exhaustion | We generated and characterized induced pluripotent stem cells (iPSCs) from ALS patients with different FUS mutations, as well as from healthy controls. | 29021520 |
| Antilymphocyte Serum | Stem Cell Exhaustion | Using motor neurons derived from induced pluripotent stem cells from patients with ALS and FUS mutations, the authors demonstrate that axonal transport deficits that are observed in these cells can be rescued by HDAC6 inhibition. | 29021520 |
| Toxic effect | Stem Cell Exhaustion | Additionally, TAUP301L neither increased neural stem cell proliferation nor activated the expression of regenerative factor Interleukin-4, indicating that TAUP301L toxicity is prevented in the adult zebrafish brain. | 29021554 |
| Lipoma | Stem Cell Exhaustion | Comparison of clinical variables, histologic analyses and characterization of the lipoma adipose-derived stem cells (ASCs) between the two lipomas were performed. | 29022421 |
| Cerebrovascular accident | Stem Cell Exhaustion | Regenerative medicine: Stroke survivor and carer views and motivations towards a proposed stem cell clinical trial using placebo neurosurgery. | 29024214 |
| Cerebrovascular accident | Stem Cell Exhaustion | Few studies explore stroke survivor views and motivations towards stem cell therapy (SCT). | 29024214 |
| Cerebrovascular accident | Stem Cell Exhaustion | This qualitative study explores the views and motivations of both stroke survivors and their partners/carers towards a proposed 2-arm Phase III Randomised Controlled Trial (RCT) comparing intracerebral insertion of stem cells with placebo neurosurgery in stroke survivors with disability. | 29024214 |
| Ischemia | Stem Cell Exhaustion | Adipose-derived mesenchymal stem cells (ASCs) have been shown to produce vascular endothelial growth factor (VEGF) and can increase perfusion in patients with critical limb ischemia. | 29025216 |
| Myeloid Cell Differentiation, Neoplasms | Stem Cell Exhaustion | Neoplasms characterized by this fusion are pluripotent stem cell disorders that can show both myeloid and lymphoid differentiation. | 29025601 |
| ibudilast | Stem Cell Exhaustion | Stem cell therapy is promising, but little is known about the differences in adipose-derived stem cells (ADSCs) between IBD patients and healthy individuals. | 29027585 |
| Inflammatory Bowel Diseases | Stem Cell Exhaustion | The features of adipose-derived stem cells in patients with inflammatory bowel diseases. | 29027585 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Acute graft-versus-host disease (aGVHD) is a major complication of allogeneic haematopoietic stem cell transplantation (HSCT). | 29027756 |
| Metaplastic carcinoma of breast | Stem Cell Exhaustion | Nestin and CD146 expression in metaplastic breast cancer: stem-cell therapy in need? | 29028085 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | In the tissue sample stem cell markers, nestin and CD146 (MCAM) were expressed, enhancing the theory that cancer cells of this tumor could possibly harbor stem cell properties. | 29028085 |
| Metaplastic carcinoma of breast | Stem Cell Exhaustion | Metaplastic breast cancer consists of cells with stem cell properties. | 29028085 |
| Liver carcinoma, Neoplasms, Specialty Type - cancer, Chromosome Aberrations | Stem Cell Exhaustion | Quantified postsurgical small cell size CTCs and EpCAM+ circulating tumor stem cells with cytogenetic abnormalities in hepatocellular carcinoma patients determine cancer relapse. | 29031565 |
| Neoplasms | Stem Cell Exhaustion | The stemness marker EpCAM+ aneuploid circulating tumor stem cells (CTSCs), and EpCAM- small CTCs with trisomy 8, promote tumor growth. | 29031565 |
| Aplastic Anemia | Stem Cell Exhaustion | Effect of Antithymocyte Globulin Source on Outcomes of HLA-Matched Sibling Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Severe Aplastic Anemia. | 29032265 |
| Aplastic Anemia | Stem Cell Exhaustion | We wanted to evaluate efficacy of porcine antithymocyte globulin (ATG) in HLA-matched sibling donor allogeneic hematopoietic stem cell transplantation (MSD-HSCT) for patients with severe aplastic anemia (SAA). | 29032265 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | We report the long-term clinical outcomes of a retrospective multicenter study that enrolled 169 patients with multiple myeloma (MM) in first relapse after failing autologous stem cell transplantation (SCT). | 29032267 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Assessment of Impact of HLA Type on Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia. | 29032274 |
| Refractory Disease | Stem Cell Exhaustion | Chemorefractory disease, often characterized by deletion of chromosome 17p, has historically been associated with very poor outcomes, leading to the application of allogeneic hematopoietic stem cell transplantation (allo-HCT) for medically fit patients. | 29032274 |
| Lymphoma | Stem Cell Exhaustion | Treatment of patients with relapsed or refractory lymphoma may require allogenic hematopoietic stem cell transplant (HSCT), but treatment of post-transplant relapse disease remains very challenging. | 29032736 |
| Charcot-Marie-Tooth Disease | Stem Cell Exhaustion | Generation of induced pluripotent stem cell (iPSC) line from Charcot-Marie-Tooth disease patient with MPZ mutation (CMT1B). | 29034895 |
| Memory | Stem Cell Exhaustion | Recently identified T memory stem (Tscm) cells have stem-cell-like properties, including long lifespan, self-renewal capacity, and multipotency to differentiate into other memory T cell types. | 29035156 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Mixed cell therapy of bone marrow-derived mesenchymal stem cells and articular cartilage chondrocytes ameliorates osteoarthritis development. | 29035380 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Here we report of a series of experiments in which bone marrow-derived stem cells (BMSCs) and articular cartilage chondrocytes (ACCs) were mixed in a 1:1 ratio and tested for their ability to enhance cartilage regeneration in three different conditions: (1) in an in vitro differentiation model; (2) in an ex vivo cartilage defect model implanted subcutaneously in mice; and (3) as an intra-articular injection in a meniscectomy-induced OA model in rats. | 29035380 |
| Thalassemia | Stem Cell Exhaustion | Long-term outcome of mixed chimerism after stem cell transplantation for thalassemia major conditioned with busulfan and cyclophosphamide. | 29035392 |
| Thalassemia | Stem Cell Exhaustion | Mixed chimerism (MC) occurs frequently after allogeneic hematopoietic stem cell transplantation (HSCT) for thalassemia major (TM) and may be associated with rejection. | 29035392 |
| B-Cell Lymphomas | Stem Cell Exhaustion | Replacing carmustine by thiotepa and cyclophosphamide for autologous stem cell transplantation in Hodgkin's and non-Hodgkin's B-cell lymphoma. | 29035395 |
| Lymphoma, Non-Hodgkin, Familial, Lymphoma, Non-Hodgkin | Stem Cell Exhaustion | The infusion of autograft absolute lymphocyte count (A-ALC) and autograft natural killer cells (A-NKC) are prognostic factors for overall survival (OS) and PFS in non-Hodgkin's lymphoma (NHL) patients undergoing autologous peripheral blood hematopoietic stem cell transplantation (APBHSCT). | 29035394 |
| Multiple Myeloma | Stem Cell Exhaustion | Novel induction agents markedly improved remission rates in multiple myeloma (MM), and the continued use of chemotherapy for CD34+ stem cell mobilization (SCM) has been questioned. | 29037891 |
| Coma, Post-Head Injury | Stem Cell Exhaustion | Effect of autologous adipose-derived mesenchymal stem cell therapy in the treatment of a post-traumatic chondral defect of the knee. | 29038190 |
| Failure | Stem Cell Exhaustion | After failure to symptomatically improve 12 months following surgery, the patient received intra-articular autologous adipose-derived mesenchymal stem cell (ADMSC) therapy. | 29038190 |
| Kidney Failure, Acute | Stem Cell Exhaustion | Allogeneic Mesenchymal Stem Cells for Treatment of AKI after Cardiac Surgery. | 29038286 |
| Kidney Failure, Acute | Stem Cell Exhaustion | We conducted a phase 2, randomized, double-blind, placebo-controlled trial in 27 centers across North America to determine the safety and efficacy of allogeneic human mesenchymal stem cells (MSCs) in reducing the time to recovery from AKI after cardiac surgery. | 29038286 |
| Endometrial disorder, Endometriosis, Endometriosis of uterus | Stem Cell Exhaustion | Using N-cadherin as a marker, the molecular and cellular characteristics of epithelial progenitor cells and their role in endometrial proliferative disorders including endometriosis, adenomyosis and thin dysfunctional endometrium can be investigated. | 29040564 |
| Protein Deficiency | Stem Cell Exhaustion | Furthermore, both in PC12 neuronal cells and in patients' induced pluripotent stem cell-derived midbrain neurons, we observed that parkin deficiencies cause the fragmentation of stable MTs. | 29040870 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Consolidation therapy with decitabine and intermediate-dose cytarabine followed by HLA-mismatched peripheral blood stem cells infusion for older patients with acute myeloid leukemia in first remission. | 29043875 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | This retrospective study tested the feasibility of decitabine (DAC) plus intermediate-dose cytarabine (ID-AraC) followed by HLA-mismatched granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral donor blood stem cells (GPBSCs) infusion as consolidation treatment for older patients with acute myeloid leukemia (AML) in first complete remission (CR). | 29043875 |
| Retinal Detachment | Stem Cell Exhaustion | Induction of focal retinal detachment (RD) for subretinal delivery of stem cells and gene therapy is increasingly common. | 29049728 |
| Specialty Type - cancer, Refractory Cytopenia of Childhood | Stem Cell Exhaustion | The aim of this study was to investigate the expression patterns and prognostic significance of the cancer stem cell marker CD133 in different histological subtypes of RCC. | 29050853 |
| Specialty Type - cancer | Stem Cell Exhaustion | Prominin-1 (CD133) is one of the most commonly used markers for cancer stem cells (CSCs), which are characterized by their ability for self-renewal and tumorigenicity. | 29050853 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Impact of Allogeneic Stem Cell Transplantation in First Complete Remission in Acute Myeloid Leukemia: A National Population-Based Cohort Study. | 29051022 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | To examine the outcomes of allogeneic stem cell transplantation (HSCT) in first complete remission (CR1) compared with chemotherapy alone in a population-based setting, we identified a cohort of patients with acute myeloid leukemia (AML) aged 15 to 70 years diagnosed between 2000 and 2014 in Denmark. | 29051022 |
| Hepatotoxicity | Stem Cell Exhaustion | Busulfan-Dependent Hepatotoxicity of Antithymocyte Globulin Formulations During Conditioning for Hematopoietic Stem Cell Transplantation. | 29051024 |
| Cessation of life, Bone marrow hypocellularity | Stem Cell Exhaustion | In competing risk analyses the cumulative incidence of severe bone marrow failure, leading to stem cell transplantation or death, was more than 70% by age 60. | 29051281 |
| Dyskeratosis Congenita, Neoplasms, Fanconi Anemia | Stem Cell Exhaustion | The risk of solid tumors following stem cell transplantation in Fanconi anemia and in dyskeratosis congenita was significantly higher than in non-transplanted patients. | 29051281 |
| Primary central nervous system lymphoma, extranodal lymphoma | Stem Cell Exhaustion | Whole-brain radiotherapy or autologous stem-cell transplantation as consolidation strategies after high-dose methotrexate-based chemoimmunotherapy in patients with primary CNS lymphoma: results of the second randomisation of the International Extranodal Lymphoma Study Group-32 phase 2 trial. | 29054815 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Long-term survival of sorafenib-treated FLT3-ITD-positive acute myeloid leukaemia patients relapsing after allogeneic stem cell transplantation. | 29055209 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD)-positive acute myeloid leukaemia (AML) relapsing after allogeneic stem cell transplantation (allo-SCT) has a dismal prognosis with limited therapeutic options. | 29055209 |
| Polycystic Kidney, Autosomal Dominant | Stem Cell Exhaustion | Generation of an induced pluripotent stem cell line, IBMS-iPSC-014-05, from a female autosomal dominant polycystic kidney disease patient carrying a common mutation of R803X in PKD2. | 29055226 |
| Polycystic Kidney, Autosomal Dominant | Stem Cell Exhaustion | Here we generated an induced pluripotent stem cell (iPSC) line from the peripheral blood mononuclear cells (PBMCs) of a 63-year-old female ADPKD patient carrying an R803X mutation in the PKD2 gene using the Sendai-virus delivery system. | 29055226 |
| Sample Size Calculation | Stem Cell Exhaustion | Adipose-derived mesenchymal stem cells (AD-MSCs) and PRPs were purified from healthy donors and SSc patients. | 29058626 |
| Multiple Myeloma | Stem Cell Exhaustion | NSAID treatment with meloxicam enhances peripheral stem cell mobilization in myeloma. | 29058701 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Chemotherapy with G-CSF is used to mobilize peripheral stem cells in multiple myeloma (MM) patients, with plerixafor as a rescue strategy for poorly mobilizing patients. | 29058701 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Blocking lymphocyte trafficking after allogeneic hematopoietic stem cell transplantation is a promising strategy to prevent graft-versus-host disease (GVHD) while preserving the graft-versus-tumor response. | 29061535 |
| Mantle cell lymphoma | Stem Cell Exhaustion | Total Body Irradiation Is Safe and Similarly Effective as Chemotherapy-Only Conditioning in Autologous Stem Cell Transplantation for Mantle Cell Lymphoma. | 29061536 |
| Medial collateral ligament, Mantle cell lymphoma | Stem Cell Exhaustion | Autologous stem cell transplant (ASCT) consolidation has become a standard approach for patients with mantle cell lymphoma (MCL), yet there is little consensus on the role of total body irradiation (TBI) as part of high-dose transplantation conditioning. | 29061536 |
| Multiple Myeloma | Stem Cell Exhaustion | Novel agent-based salvage autologous stem cell transplantation for relapsed multiple myeloma. | 29063955 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is a standard frontline therapy for multiple myeloma (MM). | 29063955 |
| Tuberculosis | Stem Cell Exhaustion | Incidence and clinical profile of tuberculosis after allogeneic stem cell transplantation. | 29064140 |
| Tuberculosis | Stem Cell Exhaustion | Patients post allogeneic stem cell transplantation (alloSCT) are expected to be at high risk of tuberculosis (TB) owing to underlying immunosuppression. | 29064140 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | The aim of this study was to identify the percentage of CD34+CD38-CD123+ cells in AML blasts, AML CD34+CD38- stem cells, and normal and regenerating bone marrow CD34+CD38- stem cells from non-myeloid malignancies. | 29065396 |
| Multiple Myeloma | Stem Cell Exhaustion | A phase 1 trial of autologous stem cell transplantation conditioned with melphalan 200 mg/m2 and total marrow irradiation (TMI) in patients with relapsed/refractory multiple myeloma. | 29065747 |
| Multiple Myeloma | Stem Cell Exhaustion | In this phase 1 study, we tested increasing doses of total marrow irradiation (TMI) in addition to standard intravenous melphalan at 200 mg/m2 (Mel200) in the conditioning regimen prior to autologous stem cell transplant (ASCT) for multiple myeloma (NCT02043847). | 29065747 |
| Osteoporosis | Stem Cell Exhaustion | STRA6 as a possible candidate gene for pathogenesis of osteoporosis from RNA-seq analysis of human mesenchymal stem cells. | 29067460 |
| Osteopenia, Osteoporosis | Stem Cell Exhaustion | To identify novel candidate genes associated with osteoporosis, RNA-sequence analysis of human mesenchymal stem cells (hMSCs) from patients with osteoporosis (G3) and osteopenia (G2), and healthy controls (G1) was performed. | 29067460 |
| Glioblastoma Multiforme Pathway, Adult Glioblastoma | Stem Cell Exhaustion | Glucocorticoids promote a glioma stem cell-like phenotype and resistance to chemotherapy in human glioblastoma primary cells: Biological and prognostic significance. | 29067692 |
| Glioblastoma Multiforme Pathway, Adult Glioblastoma, Neoplasms | Stem Cell Exhaustion | Glioma stem cells (GSCs) are glioblastoma (GBM) cells that are resistant to therapy and can give rise to recurrent tumors. | 29067692 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Acute graft-versus-host disease (aGVHD) is an important complication of allogeneic stem cell transplantation (alloSCT). | 29073260 |
| senile | Stem Cell Exhaustion | Firstly, differences in proliferative capacity of adipocyte or adipogenic differentiation in mouse mesenchymal stem cells (MMSCs) and senile mouse model-derived bone marrow mesenchymal stem cells (SMMSCs), as well as mRNA expression of OGN and PPARg2 were observed. | 29073887 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Acute graft-versus-host disease (aGVHD) remains a cause of excessive morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). | 29074374 |
| MYELODYSPLASTIC SYNDROME, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Allogeneic haematopoietic stem-cell transplantation remains the only curative treatment for relapsed/refractory acute myeloid leukaemia (AML) and high-risk myelodysplasia but has previously been limited to patients who achieve remission before transplant. | 29076145 |
| Hemolysis (biological function) | Stem Cell Exhaustion | All eight (100%) hematopoietic stem cell and 52 (95%) organ transplants were associated with hemolysis. | 29076164 |
| Hemolysis (biological function) | Stem Cell Exhaustion | Antibody screens detected five cases of hematopoietic stem cell PLS before hemolysis was apparent and two cases of organ PLS with antibodies without hemolysis. | 29076164 |
| Lymphoma, Follicular | Stem Cell Exhaustion | Overall survival (OS) is the gold-standard end point for studies evaluating autologous stem cell transplantation (ASCT) in follicular lymphoma (FL), but assessment may be elusive due to the lengthy disease course. | 29076254 |
| Lymphoma, Relapsing course | Stem Cell Exhaustion | Consolidative Radiotherapy After Autologous Stem Cell Transplantation for Relapsed or Refractory Diffuse Large B-cell Lymphoma. | 29079283 |
| Diffuse Large B-Cell Lymphoma | Stem Cell Exhaustion | We evaluated the role of consolidative radiotherapy (RT) for patients undergoing high-dose chemotherapy (HDC) and autologous stem cell transplantation (ASCT) for relapsed or refractory diffuse large B-cell lymphoma (DLBCL). | 29079283 |
| Vascular System Injuries | Stem Cell Exhaustion | We characterized vascular injury and functional recovery to understand the role of circulating endothelial progenitor cells in vascular repair. | 29080864 |
| Rheumatism | Stem Cell Exhaustion | Mesenchymal stem cells, that develop into joint tissues, show immunosuppressive and anti-inflammatory qualities, in vitro and in vivo, indicating a potential role for tissue engineering approaches in the treatment of rheumatic diseases. | 29083361 |
| PAFAH1B1 wt Allele, MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | The purpose of this study was to evaluate the strategy of haploidentical (HID) stem cell combined with a small doses of umbilical cord blood (UCB) from a third-party donor transplantation (haplo-cord transplant) for treatment of myelodysplastic syndromes (MDS), by comparing with identical-sibling donor (ISD) transplantation. | 29084206 |
| Graft-vs-Host Disease, Hematologic Neoplasms | Stem Cell Exhaustion | A total of 157 patients receiving posaconazole tablet for prophylaxis during induction therapy for haematological malignancies and allogeneic stem cell transplant recipients with graft-versus-host disease were included for analysis. | 29091205 |
| Chronic cerebrovascular accident | Stem Cell Exhaustion | In this study, we investigated whether serum a2MG levels, endothelial function, and endothelial progenitor cell (EPC) number were associated in patients with chronic stroke or cardiovascular risk factors. | 29093276 |
| Rupture, Coma, Post-Head Injury, Amyloidosis | Stem Cell Exhaustion | Atraumatic Splenic Rupture Due to Ectopic Extramedullary Hematopoiesis after Autologous Stem Cell Transplantation in a Patient with AL Amyloidosis. | 29093392 |
| Splenic Rupture | Stem Cell Exhaustion | Splenic rupture was complicated during autologous stem cell transplantation (auto-SCT). | 29093392 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | High prognostic value of pre-allogeneic stem cell transplantation minimal residual disease detection by WT1 gene expression in AML transplanted in cytologic complete remission. | 29096332 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We analyzed the outcome of allogeneic stem cell transplantation (allo-SCT) in acute myeloid leukemia (AML) patients according to molecular Minimal Residual Disease (MRD) status prior to allo-SCT. | 29096332 |
| Inflammation | Stem Cell Exhaustion | We propose that suppression of inflammation through manipulation of Panx1 activity can stimulate epithelial cell progenitor (EPCP) engraftment. | 29098296 |
| Parkinson Disease | Stem Cell Exhaustion | Human Trials of Stem Cell-Derived Dopamine Neurons for Parkinson's Disease: Dawn of a New Era. | 29100010 |
| Parkinson Disease | Stem Cell Exhaustion | Stem cell-based therapies for Parkinson's disease are moving into a new and exciting era, with several groups pursuing clinical trials with pluripotent stem cell (PSC)-derived dopamine neurons. | 29100010 |
| Secondary Acute Myeloid Leukemia, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Outcome after relapse of myelodysplastic syndrome and secondary acute myeloid leukemia following allogeneic stem cell transplantation: a retrospective registry analysis on 698 patients by the Chronic Malignancies Working Party of the European Society of Blood and Marrow Transplantation. | 29101205 |
| Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | No standard exists for the treatment of myelodysplastic syndrome relapsing after allogeneic stem cell transplantation. | 29101205 |
| Malignant tumor of colon | Stem Cell Exhaustion | Immunohistochemistry was used to assess the expression of putative stem cell markers (ALDH1, CD44v6, CD133, Lgr5, SOX2) and immune cell related markers (CD3, CD8, FoxP3, PD-L1) in 104 patients with stage III colon cancer. | 29102042 |
| Leukemia, Myelocytic, Acute, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | DICER1 gene and miRNA dysregulation in mesenchymal stem cells of patients with myelodysplastic syndrome and acute myeloblastic leukemia. | 29102598 |
| Infection | Stem Cell Exhaustion | Poor Adherence Is Associated with More Infections after Pediatric Hematopoietic Stem Cell Transplant. | 29102720 |
| Injury of kidney | Stem Cell Exhaustion | Mesenchymal Stem Cells Contribute to Improvement of Renal Function in a Canine Kidney Injury Model. | 29102933 |
| Kidney Failure, Acute | Stem Cell Exhaustion | In the present study, mesenchymal stem cells derived from canine umbilical cord blood (cUCB-MSCs) were isolated and evaluated for their ability to improve renal function in a canine model of acute kidney injury (AKI). | 29102933 |
| Prostate carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Cancer Stem Cell Gene Variants Predict Disease Recurrence in Patients Treated with Radical Prostatectomy for Prostate Cancer. | 29104488 |
| Specialty Type - cancer, Neoplasms | Stem Cell Exhaustion | Background: Cancer stem cells (CSCs) are involved in tumor progression and drug resistance. | 29104488 |
| Endometrial Neoplasms | Stem Cell Exhaustion | To report a series of 11 ovarian and one endometrial neoplasm in elderly patients with mixed clear cell tumour and germ cell tumour (GCT) components, to compare their immunohistochemical profiles and demonstrate a putative stem cell population. | 29106744 |
| Embryonal Carcinoma | Stem Cell Exhaustion | However, there may also be undifferentiated stem cell areas with embryoid bodies, of the type seen in postpubertal testicular GCT, but lacking a complete embryonal carcinoma immunophenotype. | 29106744 |
| Adenocarcinoma, Clear Cell, Neoplasms | Stem Cell Exhaustion | Germ cell tumour growth patterns originating from clear cell carcinomas of the ovary and endometrium: a comparative immunohistochemical study favouring their origin from somatic stem cells. | 29106744 |
| Somatic | Stem Cell Exhaustion | We propose that OCT4-expressing somatic cancer cells differentiate into GCT and represent spontaneously induced pluripotent stem cells, possibly conditioned by age-related epigenetic factors. | 29106744 |
| Lichen disease | Stem Cell Exhaustion | Epithelial-to-Mesenchymal Stem Cell Transition in a Human Organ: Lessons from Lichen Planopilaris. | 29106928 |
| Alopecia, Lichen disease | Stem Cell Exhaustion | Here, we show that EMT also occurs within the bulge, the epithelial stem cell (eSC) niche of human scalp hair follicles, during the inflammatory permanent alopecia, lichen planopilaris. | 29106928 |
| Microcephaly | Stem Cell Exhaustion | ZIKV has been shown to infect neuronal progenitor cells of the fetal mouse brain, which is comparable to the first-trimester human fetal brain, and result in microcephaly. | 29107512 |
| Bone Marrow | Stem Cell Exhaustion | Univariate Cox model analysis showed that increased age, high white blood cell count, t (8;21) cytogenetic group, and high bone marrow blast percentage were associated with poor overall outcome, while stem cell transplant intervention was associated with better survival. | 29107583 |
| Cessation of life | Stem Cell Exhaustion | Multivariate Cox model analysis showed that t(8;21) cytogenetic group has more hazard of death after adjusting, age, marrow blast percentage, blood cell count, and stem cell transplant(hazard ratio 1.802; P = .02). | 29107583 |
| Malignant tumor of colon | Stem Cell Exhaustion | Using the stem cell markers CD133, CD166 and CD44, we found a subpopulation of highly tumorigenic human colon cancer cells. | 29110645 |
| Malignant tumor of colon | Stem Cell Exhaustion | Long intergenic non-protein-coding RNA 1567 (LINC01567) acts as a "sponge" against microRNA-93 in regulating the proliferation and tumorigenesis of human colon cancer stem cells. | 29110645 |
| Specialty Type - cancer, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Cancer stem cells (CSCs) are considered to be the major factor in tumor initiation, progression, metastasis, recurrence and chemoresistance. | 29110645 |
| Pneumocystis jiroveci pneumonia, Superinfection, Coinfection | Stem Cell Exhaustion | Influenza and Pneumocystis jirovecii pneumonia in an allogeneic hematopoietic stem cell transplantation recipient: Coinfection or superinfection? | 29111605 |
| Pneumocystis jiroveci pneumonia, Influenza, Infection | Stem Cell Exhaustion | Influenza infection and Pneumocystis jirovecii pneumonia (PJP) in hematopoietic stem cell transplant (HSCT) patients are well characterized; however, no dual infections have been reported in this patient population and little evidence of mechanisms of interaction between the two infections exists. | 29111605 |
| atherosclerotic, Coronary Arteriosclerosis | Stem Cell Exhaustion | Adipose-tissue derived mesenchymal stem cell (ADSC)-based therapy is a promising option for patients with atherosclerotic conditions, including coronary artery disease. | 29115374 |
| Temporomandibular Joint | Stem Cell Exhaustion | Synovial fluid-derived synovial fragments represent an improved source of synovial mesenchymal stem cells in the temporomandibular joint. | 29115378 |
| Dissection of aorta | Stem Cell Exhaustion | Transcriptome sequencing revealed candidate genes relevant to mesenchymal stem cells' role in aortic dissection patients. | 29115411 |
| Up | Stem Cell Exhaustion | Mesenchymal stem cells (MSCs) are known for anti-inflammatory and repairing effects and have therefore been studied for treatment for numerous diseases, including AD. | 29115411 |
| Fibrosis Assessment, Dilated Cardiomyopathy Pathway, Cardiac dysfunction | Stem Cell Exhaustion | Human umbilical cord mesenchymal stem cells alleviate interstitial fibrosis and cardiac dysfunction in a dilated cardiomyopathy rat model by inhibiting TNF-a and TGF-b1/ERK1/2 signaling pathways. | 29115435 |
| Doctor of Chiropractic | Stem Cell Exhaustion | In the present study, the beneficial role of human umbilical cord-derived mesenchymal stem cells (HuMSCs) derived from Wharton's jelly was evaluated in the myosin-induced rat model of DCM. | 29115435 |
| Pancytopenia, Bone marrow hypocellularity, Aplastic Anemia, primary disorders | Stem Cell Exhaustion | Severe aplastic anemia (SAA) is a primary disorder of severe bone marrow failure characterizing with extreme pancytopenia and a profound diminution of bone marrow progenitor cells, which is associated with T cell hyper-function. | 29115638 |
| Polycystic Kidney, Autosomal Dominant | Stem Cell Exhaustion | Induced pluripotent stem cells derived from an autosomal dominant polycystic kidney disease patient carrying a PKD1 Q533X mutation. | 29121521 |
| Kidney Failure, Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | We generated induced pluripotent stem cells (iPSCs) from a 37-year-old man carrying a PKD1 Q533X mutation who suffered from kidney failure and a myocardial infarction. | 29121521 |
| Liver carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | SOX9 is a proliferation and stem cell factor in hepatocellular carcinoma and possess widespread prognostic significance in different cancer types. | 29121666 |
| Specialty Type - cancer, Childhood Breast Carcinoma | Stem Cell Exhaustion | Functional SOX9 knock-down studies using siRNA and cancer stem cell models were generated in a panel of liver and breast cancer cell lines. | 29121666 |
| Chronic disease, Usual Severity Pain | Stem Cell Exhaustion | The effect of pre-transplant pain and chronic disease self-efficacy on quality of life domains in the year following hematopoietic stem cell transplantation. | 29124418 |
| Usual Severity Pain | Stem Cell Exhaustion | Pain is common for hematopoietic stem cell transplant (HSCT) patients and may be experienced pre-transplant, acutely post-transplant, and for months or years following transplant. | 29124418 |
| Specialty Type - cancer | Stem Cell Exhaustion | YKL-40 (also known as Chitinase 3-like 1) is a glycoprotein produced by inflammatory, cancer and stem cells. | 29126445 |
| Glioblastoma | Stem Cell Exhaustion | In the other two, adults with glioblastoma multiforme received neural progenitor cell sparing radiation or no sparing with extra dose delivered to subventricular zone. | 29128167 |
| Chronic Lymphocytic Leukemia, Lymphoma | Stem Cell Exhaustion | Combined Haploidentical and Umbilical Cord Blood Allogeneic Stem Cell Transplantation for High-Risk Lymphoma and Chronic Lymphoblastic Leukemia. | 29128555 |
| Malignant Neoplasms | Stem Cell Exhaustion | Limited studies have reported on outcomes for lymphoid malignancy patients receiving alternative donor allogeneic stem cell transplants. | 29128555 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | We analyzed 42 lymphoma and chronic lymphoblastic leukemia (CLL) patients who underwent haplo-cord allogeneic stem cell transplantation. | 29128555 |
| Dystonia 3, Torsion, X-Linked | Stem Cell Exhaustion | Generation of induced pluripotent stem cell line (ZZUi005-A) from a 21-year-old patient with a novel RAB39B gene mutation in X-linked juvenile parkinsonism. | 29128816 |
| Dystonia 3, Torsion, X-Linked | Stem Cell Exhaustion | Recently, a novel RAB39B mutation was identified in an X-linked juvenile parkinsonism family and the dermal fibroblasts of the patient were obtained and successfully induced to induced pluripotent stem cells (iPSCs) by the human OSKM transcription factors using the Sendai-virus delivery system. | 29128816 |
| Adrenoleukodystrophy | Stem Cell Exhaustion | Generation of induced pluripotent stem cell (iPSC) line from a 21-year-old X-linked adrenoleukodystrophy (X-ALD) patient. | 29128817 |
| Adrenoleukodystrophy | Stem Cell Exhaustion | We generated an induced pluripotent stem cell (iPSC) line from a 21-year-old male X-ALD patient-derived fibroblasts by Sendai virus mediated reprogramming. | 29128817 |
| Liver carcinoma, Primary Malignant Liver Neoplasm, Intrahepatic Cholangiocarcinoma, Hollings Cancer Center | Stem Cell Exhaustion | Recent animal studies indicate that disruption of NF2/Merlin function in oval cells, which are hepatic progenitor cells, may lead to the development of primary liver cancers including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC); however, its role in human primary liver cancer remains unclear. | 29130106 |
| Specialty Type - cancer | Stem Cell Exhaustion | Spheroid colony formation is a useful method of cancer stem cell (CSC) characterization. | 29131081 |
| neurological complication | Stem Cell Exhaustion | Neurologic complications after allogeneic hematopoietic stem cell transplantation: risk factors and impact. | 29131150 |
| Multiple Myeloma | Stem Cell Exhaustion | Elevated pre-transplant C-reactive protein identifies a high-risk subgroup in multiple myeloma patients undergoing delayed autologous stem cell transplantation. | 29131152 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | The significance of elevated C-reactive protein (CRP) prior to autologous stem cell transplantation (ASCT) in multiple myeloma (MM) has not been studied. | 29131152 |
| Renal Cell Carcinoma Pathway | Stem Cell Exhaustion | Impact of HLA-G polymorphism on the outcome of allogeneic hematopoietic stem cell transplantation for metastatic renal cell carcinoma. | 29131154 |
| Keratopathy | Stem Cell Exhaustion | To relate central corneal epithelial phenotype to degree of keratopathy in a limbal stem cell deficient population. | 29133179 |
| Angiomyolipoma of kidney, Neoplasms, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Renal angiomyolipomas (AML) contain an admixture of clonal tumour cells with features of several different mesenchymal lineages, implying the existence of an unidentified AML neoplastic stem cell. | 29133867 |
| Angiomyolipoma of kidney | Stem Cell Exhaustion | Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells. | 29133867 |
| Febrile Neutropenia | Stem Cell Exhaustion | Neutropenic fever during peripheral blood progenitor cell mobilization is associated with decreased CD34+ cell collection and increased apheresis collection days. | 29134688 |
| Febrile Neutropenia | Stem Cell Exhaustion | Peripheral blood progenitor cell (PBPC) mobilization with chemotherapy in addition to Granulocyte-Colony Stimulating Factor (G-CSF) improves cell collection compared to G-CSF alone; however, it is associated with increased risk of neutropenic fever (NF). | 29134688 |
| Exanthema | Stem Cell Exhaustion | Erythematous Rash Following Hematopoietic Stem Cell Transplantation. | 29136426 |
| Brain Damage, Chronic, Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplant reflects a complex immune response resulting in chronic damage to multiple tissues. | 29138220 |
| Ischemia | Stem Cell Exhaustion | Walking exercise may augment the effects of GM-CSF in PAD, since exercise-induced ischemia enhances progenitor cell release and may promote progenitor cell homing to ischemic calf muscle. | 29141087 |
| Stable chronic Graft vs Host Disease, Chronic graft-versus-host disease | Stem Cell Exhaustion | Growing numbers of allogeneic stem cell transplants and improved posttransplant care have led to an increase of individuals with chronic graft-versus-host disease (cGVHD). | 29141183 |
| Radiation injury of bone marrow | Stem Cell Exhaustion | Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice. | 29141658 |
| McMaster University Epidemiology Terms, Radiation injury | Stem Cell Exhaustion | Protection and/or mitigation of hematopoietic stem cells (HSCs) from radiation injury is an important goal in the development of medical countermeasure agents (MCM). | 29141658 |
| Cessation of life | Stem Cell Exhaustion | Neurogenic niches (SVZ and dentate gyrus) were analysed by confocal microscopy using markers of proliferation (Ki-67, PCNA), neuroblasts (PSA-NCAM, DCX, Tuj1), stem cells (Nestin, GFAPd, SOX2, PAX6, Musashi), astrocytes (GFAP, AQ4), oligodendrocytes (NG2, Olig), microglia and cell infiltrates (IBA-1, CD68, MHCII), and cell death (TUNEL). | 29141824 |
| Pancytopenia | Stem Cell Exhaustion | Long-term outcome in patients treated at home during the pancytopenic phase after allogeneic haematopoietic stem cell transplantation. | 29143281 |
| Pancytopenia | Stem Cell Exhaustion | Patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) were given the option to be treated at home during the pancytopenic phase. | 29143281 |
| Childhood Breast Carcinoma, Squamous metaplasia | Stem Cell Exhaustion | Meanwhile, it was positive for CD44 variant isoforms (CD44v), which is a breast cancer stem cell (CSC) marker, and expressed in LGASC, squamous metaplasia, and ASP. | 29145336 |
| Mantle cell lymphoma | Stem Cell Exhaustion | R-hyper-CVAD versus R-CHOP/cytarabine with high-dose therapy and autologous haematopoietic stem cell support in fit patients with mantle cell lymphoma: 20 years of single-center experience. | 29147847 |
| Medial collateral ligament | Stem Cell Exhaustion | At the University Hospital Zurich, advanced MCL in physically fit patients is treated either with rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone induction followed by consolidating high-dose chemotherapy and autologous stem cell support (R-CHOP/HD-ASCT), or with rituximab plus fractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone alternating with high-dose methotrexate-cytarabine (R-hyper-CVAD/MTX-AraC) without consolidating HD-ASCT upon physicians' and patients' choice. | 29147847 |
| Ischemic stroke | Stem Cell Exhaustion | Mobilization of endothelial progenitor cell in patients with acute ischemic stroke. | 29147957 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | Influence of Oral Anaerobic Bacteria on Hematopoietic Stem Cell Transplantation Patients: Oral Mucositis and General Condition. | 29149979 |
| PAFAH1B1 wt Allele, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Treatment of relapsed AML and MDS after allogeneic stem cell transplantation with decitabine and DLI-a retrospective multicenter analysis on behalf of the German Cooperative Transplant Study Group. | 29151133 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Autologous stem cell transplantation and stem cell mobilization kinetics in elderly patients with B cell non-Hodgkin lymphoma. | 29153347 |
| Aggressive Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplantation (HSCT) is the standard treatment modality in chemotherapy-sensitive relapsed or refractory aggressive lymphomas. | 29153347 |
| Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | Even in the modern era of targeted therapies, allogeneic hematopoietic stem cell transplantation (allo-HCT) can offer a chance of extended survival in B cell non-Hodgkin lymphoma (B-NHL) patients who relapse after or are deemed ineligible for autologous transplantation. | 29155319 |
| Non-Neoplastic Hematologic and Lymphocytic Disorder | Stem Cell Exhaustion | Haploidentical stem cell transplantation (haplo-SCT) provides an alternative method to cure patients with malignant and nonmalignant hematologic diseases who lack a human leukocyte antigen (HLA) matched related or unrelated donor. | 29155367 |
| Fibrosis Assessment | Stem Cell Exhaustion | Hepatic progenitor cells (HPCs) and hepatic stellate cells (HSCs) have been implicated in fibrosis progression in chronic HCV. | 29155473 |
| Fibrosis Assessment | Stem Cell Exhaustion | Hepatic progenitor cells and stellate cells play a significant role in the development and progression of fibrosis in chronic HCV. | 29155473 |
| Specialty Type - cancer, Adult Glioblastoma, Neoplasms | Stem Cell Exhaustion | The Invasive Region of Glioblastoma Defined by 5ALA Guided Surgery Has an Altered Cancer Stem Cell Marker Profile Compared to Central Tumour. | 29156557 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Modulation of Gene Expression in Infrapatellar Fat Pad-Derived Mesenchymal Stem Cells in Osteoarthritis. | 29156945 |
| Degenerative polyarthritis, Abnormal degeneration | Stem Cell Exhaustion | Conclusion OA of the knee also affects the mesenchymal stem cells of Hoffa fat, suggesting that Hoffa fat is a new actor in the OA degenerative process that can contribute to the origin, onset, and progression of the disease. | 29156945 |
| Neoplasms, Childhood Craniopharyngioma | Stem Cell Exhaustion | Stem cells have been discovered as key players in the genesis of different neoplasms including craniopharyngioma (CP), a rare tumour entity in the sellar region. | 29158570 |
| Neoplasms, Childhood Breast Carcinoma | Stem Cell Exhaustion | Claudin-6 (CLDN6), a critical tight junction protein acting as a tumor suppressor in breast cancer, is also considered to be a stem cell marker. | 29159771 |
| Triple-Negative Breast Cancer Finding, Childhood Breast Carcinoma | Stem Cell Exhaustion | Triple-negative breast cancer (TNBC) is a subtype of claudin-low and stem cell-like breast cancer which is chemoresistant to multiple anti-cancer drugs. | 29159771 |
| Specialty Type - cancer | Stem Cell Exhaustion | Together, we conclude that CLDN6 enhances the chemoresistance to ADM via activating the AF-6/ERK signaling pathway and up-regulating cancer stem cell characters in MDAMB231 cells. | 29159771 |
| Keratopathy, Aniridia | Stem Cell Exhaustion | Patients with aniridia often develop aniridia-related keratopathy (ARK), due to limbal stem cell insufficiency. | 29162348 |
| Hematopoietic Stem Cell Mobilization | Stem Cell Exhaustion | Biosimilar filgrastim (Leucostim(r)) was shown to be similar in terms of efficacy and safety in hematopoietic progenitor cell mobilization (HPCM) compared to originator filgrastim (Neupogen(r)) and lenograstim (Granocyte(r)) in healthy donors and chemomobilization settings. | 29162397 |
| Hematologic Neoplasms | Stem Cell Exhaustion | Allogeneic peripheral blood stem cell (APBSCs) transplantation is an effective treatment for hematological malignancies. | 29162400 |
| Adult Glioblastoma | Stem Cell Exhaustion | Dual-targeting immunoliposomes using angiopep-2 and CD133 antibody for glioblastoma stem cells. | 29162480 |
| Adult Glioblastoma, Neoplasms, Glioblastoma | Stem Cell Exhaustion | Glioblastoma stem cells (GSCs), which are identified as subpopulation of CD133+/ALDH1+, are known to show resistance to the most of chemotherapy and radiation therapy, leading to the recurrence of tumor in glioblastoma multiforme (GBM) patients. | 29162480 |
| Lymphoma, Non-Hodgkin, Familial, Hodgkin Disease, Childhood Non-Hodgkin Lymphoma | Stem Cell Exhaustion | The combination of carmustine, etoposide, aracytin, and melphalan(BEAM) conditioning regimen in autologous stem-cell transplantation (ASCT) is widely used in patients with relapsed/refractory non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma. | 29164977 |
| Dysplasia | Stem Cell Exhaustion | A combination of proteins mucin-5AC and prostate stem-cell antigen could identify high-grade dysplasia/cancer with an accuracy of 96% (95% CI, 90% to 99%), and detected 95% of malignant/severely dysplastic lesions, compared with 35% and 50% for carcinoembryonic antigen and cytology ( P < .001 and P = .003, respectively). | 29166170 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Gastrointestinal (GI) graft-versus-host-disease (GVHD) is a common and severe complication of allogeneic hematopoietic stem cell transplantation, but clinical and histological features are unspecific. | 29167990 |
| Infections, Hospital, Clostridium difficile | Stem Cell Exhaustion | Screening for Clostridium difficile colonization on admission to a hematopoietic stem cell transplant unit may reduce hospital-acquired C difficile infection. | 29169936 |
| Clostridium difficile colitis | Stem Cell Exhaustion | Clostridium difficile infection rates are higher in patients undergoing hematopoietic stem cell transplants. | 29169936 |
| Colonization | Stem Cell Exhaustion | In our study, patients undergoing hematopoietic stem cell transplants or chemotherapy were screened for C difficile colonization at admission and placed on contact precautions if they were positive. | 29169936 |
| Pulmonary Dysfunction | Stem Cell Exhaustion | Obstructive and restrictive pulmonary dysfunction in long-term lymphoma survivors after high-dose therapy with autologous stem cell transplantation. | 29171324 |
| physiopathological | Stem Cell Exhaustion | Obstructive and restrictive dysfunction in long-term lymphoma survivors (LSs) after high-dose therapy with autologous stem-cell transplantation (HDT-ASCT) has not been addressed systematically previously. | 29171324 |
| Glycogen Storage Disease Type IIb | Stem Cell Exhaustion | Characteristics of induced pluripotent stem cells from clinically divergent female monozygotic twins with Danon disease. | 29175505 |
| Glycogen Storage Disease Type IIb | Stem Cell Exhaustion | Induced pluripotent stem cells (iPSCs) have been generated from patients with various forms of disease, including Danon disease (DD); however, few reports exist regarding disease-specific iPSCs derived from clinically divergent monozygotic twins. | 29175505 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Minimal residual disease by either flow cytometry or cytogenetics prior to an allogeneic hematopoietic stem cell transplant is associated with poor outcome in acute myeloid leukemia. | 29176662 |
| Graft-vs-Host Disease, Communicable Diseases | Stem Cell Exhaustion | No indication of increased infection rates using low-dose alemtuzumab instead of anti-thymocyte globulin as graft-versus-host disease prophylaxis before allogeneic stem cell transplantation. | 29178248 |
| Cytomegalovirus, Fever, Toxoplasmosis, Communicable Diseases | Stem Cell Exhaustion | We performed a retrospective, single-center, case-control study analyzing the rates of neutropenic fever, cytomegalovirus (CMV) reactivation, Epstein-Barr virus (EBV) reactivation, clinical manifest toxoplasmosis, and clinical manifest human herpesvirus-6 (HHV6) infection using low-dose alemtuzumab in comparison with anti-thymocyte globulin (ATG) as GvHD prophylaxis before allogeneic stem cell transplantation. | 29178248 |
| Infection | Stem Cell Exhaustion | We saw no indication of increased infections rates when using low-dose alemtuzumab as GvHD prophylaxis before allogeneic stem cell transplantation in this retrospective analysis. | 29178248 |
| Adult Glioblastoma | Stem Cell Exhaustion | A stem cell marker, CD133, was reported to predict recurrence patterns in intracranial glioblastoma. | 29180077 |
| Pituitary Neoplasms, Childhood Craniopharyngioma | Stem Cell Exhaustion | Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma. | 29180744 |
| Neoplasms | Stem Cell Exhaustion | We show that expression of oncogenic b-catenin in Hesx1+ embryonic precursors also results in stem cell clusters and paracrine tumours. | 29180744 |
| Neoplasms | Stem Cell Exhaustion | Together, we provide evidence that senescence and a stem cell-associated SASP drive cell transformation and tumour initiation in vivo in an age-dependent fashion. | 29180744 |
| Neoplasms, American College of Physicians, Adamantinous Craniopharyngioma | Stem Cell Exhaustion | Expression of oncogenic b-catenin in Sox2+ young adult pituitary stem cells leads to formation of clusters of stem cells and induction of tumours resembling human adamantinomatous craniopharyngioma (ACP), derived from Sox2- cells in a paracrine manner. | 29180744 |
| HIV-1 Infection Pathway | Stem Cell Exhaustion | Notwithstanding 1 documented case of HIV-1 cure following allogeneic stem cell transplantation (allo-SCT), several subsequent cases of allo-SCT in HIV-1 positive individuals have failed to cure HIV-1 infection. | 29182633 |
| Subglottic stenosis | Stem Cell Exhaustion | The aim of this study was to evaluate the effect of human adipose tissue-derived mesenchymal stem cells (hAMSCs) in rat model of subglottic stenosis. | 29185355 |
| Kidney Failure, Chronic, Thoracic spinal cord structure | Stem Cell Exhaustion | Improvement of renal function after human umbilical cord mesenchymal stem cell treatment on chronic renal failure and thoracic spinal cord entrapment: a case report. | 29187247 |
| Kidney Failure, Chronic | Stem Cell Exhaustion | Mesenchymal stem cell studies in animal models of chronic renal failure have uncovered a unique potential of these cells for improving function and regenerating the damaged kidney. | 29187247 |
| Kidney Failure, Entrapment of Device | Stem Cell Exhaustion | Human umbilical cord mesenchymal stem cell implantations led to significant improvement for spinal cord entrapment and kidney failure. | 29187247 |
| Specialty Type - cancer, Malignant Neoplasms | Stem Cell Exhaustion | Conclusion: By considering these results as the fundamental information for MIS, our system could be applied to induce senescence in treatment-resistant cancers such as metastatic cancer or cancer stem cells. | 29187894 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | Although patient-sourced cardiac explant-derived stem cells (EDCs) provide an exogenous source of new cardiomyocytes post-myocardial infarction, poor long-term engraftment indicates that the benefits seen in clinical trials are likely paracrine-mediated. | 29187908 |
| Myocardial | Stem Cell Exhaustion | Silencing IL-6 in EDCs abrogated much of the benefits conferred by cell transplantation and revealed that IL-6 prompts cardiac fibroblasts and macrophages to reduce myocardial scarring while increasing the generation of new cardiomyocytes and recruitment of blood stem cells. | 29187908 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | 10-year complete remission in a Philadelphia chromosome-positive acute lymphoblastic leukemia patient using imatinib without high-intensity chemotherapy or allogeneic stem cell transplantation. | 29188580 |
| Adult Glioblastoma | Stem Cell Exhaustion | Determinants for Effective ALECSAT Immunotherapy Treatment on Autologous Patient-Derived Glioblastoma Stem Cells. | 29190492 |
| Specialty Type - cancer | Stem Cell Exhaustion | Here we performed a paired pre-clinical study to investigate the composition and in vitro effect of ALECSAT and identify determinants for the effect using autologous GBM-derived cancer stem cells (CSC), immunocytochemistry and flow cytometry. | 29190492 |
| Degenerative polyarthritis | Stem Cell Exhaustion | CD105+-mesenchymal stem cells migrate into osteoarthritis joint: An animal model. | 29190645 |
| Hypertensive (finding) | Stem Cell Exhaustion | Association of circulating progenitor cells with angiotensin II in newly diagnosed hypertensive patients. | 29192185 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | The histopathologic diagnosis of hepatic graft-versus-host disease post bone marrow and stem cell transplantation can be challenging, but timely and unambiguous diagnosis is essential for appropriate patient management. | 29192646 |
| Liver damage | Stem Cell Exhaustion | Direct thaw and administration of previously cryopreserved peripheral blood stem cell products is a commonly used practice and should be performed rapidly to reduce cellular damage caused by dimethyl sulfoxide exposure. | 29193156 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | Purification of a stem-cell like side-population (SP) from ovarian cancer cell lines was performed by flow cytometry/FACS. | 29194596 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | In conclusion, Vav3.1 is over-expressed in stem-cell like SP fractions and is clinically relevant in the pathophysiology of ovarian cancer. | 29194596 |
| Malignant neoplasm of ovary | Stem Cell Exhaustion | Truncated isoform Vav3.1 is highly expressed in ovarian cancer stem cells and clinically relevant in predicting prognosis and platinum-response. | 29194596 |
| Peripheral T-Cell Lymphoma | Stem Cell Exhaustion | Optimal salvage therapy for primary refractory peripheral T-cell lymphomas (PTCL) and the role of hematopoietic stem cell transplant (SCT) remain poorly defined. | 29194714 |
| Leukemia, Myelomonocytic, Chronic | Stem Cell Exhaustion | Prognostic Impact of Donor Source on Allogeneic Hematopoietic Stem Cell Transplantation Outcomes in Adults with Chronic Myelomonocytic Leukemia: A Nationwide Retrospective Analysis in Japan. | 29196081 |
| Leukemia, Myelomonocytic, Chronic | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapeutic option for patients with chronic myelomonocytic leukemia (CMML). | 29196081 |
| Lymphoma | Stem Cell Exhaustion | Outcomes after Allogeneic Stem Cell Transplantation in Patients with Double-Hit and Double-Expressor Lymphoma. | 29196080 |
| Lymphoma | Stem Cell Exhaustion | Double-hit lymphomas (DHLs) and double-expressor lymphomas (DELs) are associated with resistance to frontline and salvage immunochemotherapy, as well as autologous stem cell transplantation (SCT). | 29196080 |
| Neoplasms | Stem Cell Exhaustion | In B-CLL cells, some remarkable unique features like the loss of tumor suppressor molecules PNN and JARID2, the stress-related serotonin transporter SLC6A4, and high expression of ZNF207, CCDC88A, PIGR and ID3, otherwise associated with stem cell phenotype, were determined. | 29196338 |
| Neoplasms, Specialty Type - cancer | Stem Cell Exhaustion | Pathway enrichment, predicted drug response, tumor microenvironment infiltration, cancer immunotherapy antigen profiling, and miRNA target enrichment were assessed.Results: AA-enriched differential gene expression was characterized by stem cell and invasion pathways. | 29196495 |
| Congenital Abnormality, LMNA wt Allele, Cockayne Syndrome | Stem Cell Exhaustion | By using the redifferentiation of four patient-derived induced pluripotent stem cells as a model for the onset of progeroid syndromes, we tracked the progression of RT abnormalities during development, revealing altered RT of the TP63 gene as an early event in disease progression of both HGPS and RTS. | 29196523 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Acute graft-versus-host disease (aGVHD) is 1 of the main major complications of post-hematopoietic stem cell transplantation (HSCT). | 29197674 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Various approaches have been developed for ex vivo T cell depletion in allogeneic stem cell transplantation to prevent graft-versus-host disease (GVHD). | 29197677 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | Burden of oral mucositis in stem cell transplant patients-the patients' perspective. | 29197961 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | Purpose of this study was to determine the impact of Oral Mucositis (OM) on health-related quality of life (HRQoL) and quality of life associated symptoms and functions in patients undergoing hematopoietic stem cell transplantation (HSCT). | 29197961 |
| Nocardia Infections, Inappropriate ADH Syndrome | Stem Cell Exhaustion | The syndrome of inappropriate antidiuretic hormone secretion (SIADH) has been described thus far in lung and stem cell transplants with systemic nocardiosis. | 29198680 |
| Graft-vs-Host Disease | Stem Cell Exhaustion | Anti-thymocyte globulin (ATG) is often added to hematopoietic stem cell transplant conditioning regimens to prevent graft rejection and reduce graft-versus-host disease (GVHD). | 29199482 |
| Multiple Myeloma | Stem Cell Exhaustion | The mainstay of treatment of myeloma is induction treatment followed by consolidation with autologous stem cell transplant (ASCT). | 29199718 |
| Hyperkalemia, Nephrotoxic | Stem Cell Exhaustion | Of note, hyperkalemia was observed in more patients who received allogeneic hematopoietic stem cell transplantation (P=0.0303) and concomitant treatment with nephrotoxic drugs (P=0.0281). | 29203252 |
| Malignant Neoplasms, Neoplasms, Secondary Neoplasm | Stem Cell Exhaustion | Twist1 is a key transcription factor, which confers tumor cells with cancer stem cell (CSC)-like characteristics and enhances epithelial-mesenchymal transition in pathological conditions including tumor malignancy and metastasis. | 29204790 |
| Osteoporosis, Postmenopausal | Stem Cell Exhaustion | In vitro cell behaviors of bone mesenchymal stem cells derived from normal and postmenopausal osteoporotic rats. | 29207050 |
| Squamous cell carcinoma | Stem Cell Exhaustion | Adipose-derived stem cell conditioned medium attenuates cisplatin-triggered apoptosis in tongue squamous cell carcinoma. | 29207154 |
| Apoptosis | Stem Cell Exhaustion | Moreover, adipose-derived stem cell conditioned medium markedly inhibited cisplatin-induced apoptotic cell death (sub-G1 phase) in the CAL-27 cells. | 29207154 |
| Cessation of life | Stem Cell Exhaustion | Taken together, we provide evidence that adipose-derived stem cell conditioned medium protects CAL-27 cells from cisplatin-induced cell death, possibly through upregulation of the IGF-1R/AKT/ERK signaling pathway. | 29207154 |
| Specialty Type - cancer | Stem Cell Exhaustion | To evaluate the interaction of tongue cancer cells and adipose-derived stem cells, we performed a series of in vitro experiments. | 29207154 |
| Damage | Stem Cell Exhaustion | Mesenchymal stem cell (MSC)-based therapies have had positive outcomes in the treatment of DOXO-induced cardiac damage; however, DOXO exerts toxic effects on MSCs, decreasing the effectiveness of MSC therapy. | 29207187 |
| doxorubicin | Stem Cell Exhaustion | Macrophage migration inhibitory factor rescues mesenchymal stem cells from doxorubicin-induced senescence though the PI3K-Akt signaling pathway. | 29207187 |
| Cessation of life, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Treatment with combined VS-5584, SCH772984, and ABT-199 showed significant increase in cell death in AML cell lines and primary patient samples and significant reduction in AML colony formation in primary patient samples, while there was no significant effect on colony formation of normal human CD34+ hematopoietic progenitor cells. | 29208365 |
| Electrocardiogram: myocardial infarction (finding) | Stem Cell Exhaustion | TIME Trial: Effect of Timing of Stem Cell Delivery Following ST-Elevation Myocardial Infarction on the Recovery of Global and Regional Left Ventricular Function: Final 2-Year Analysis. | 29208679 |
| Rheumatoid Arthritis | Stem Cell Exhaustion | Articular and subcutaneous adipose tissues of rheumatoid arthritis patients represent equal sources of immunoregulatory mesenchymal stem cells. | 29212384 |
| TAO brand of troleandomycin, Thyroid associated opthalmopathies | Stem Cell Exhaustion | The purpose of this study was to characterize the intrinsic cellular properties of orbital adipose-derived stem cells (OASC) from patients with thyroid-associated orbitopathy (TAO) and healthy controls. | 29214313 |
| Toxic effect, Multiple Myeloma | Stem Cell Exhaustion | Melphalan at a dose of 200 mg/m2 is standard conditioning prior to autologous hematopoietic stem cell transplantation for multiple myeloma, but a dose of 140 mg/m2 is often used in clinical practice in patients perceived to be at risk of excess toxicity. | 29217776 |
| Neoplasms, Multiple Myeloma | Stem Cell Exhaustion | Prognostic significance of tumor burden assessed by whole-body magnetic resonance imaging in multiple myeloma patients treated with allogeneic stem cell transplantation. | 29217779 |
| Multiple Myeloma | Stem Cell Exhaustion | Allogeneic stem cell transplantation is a therapeutic option under dispute but nonetheless chosen with increasing frequency for patients suffering from multiple myeloma in Europe. | 29217779 |
| Neoplasms | Stem Cell Exhaustion | To study possible predictors of survival, 79 patients were investigated using whole-body magnetic resonance imaging to assess the visible tumor burden before and after allogeneic stem cell transplantation. | 29217779 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | As surrogate for changes in management, we found an increase of allogeneic haematopoietic stem cell transplantations (1.4 to 7%) and clinical trial activities (25 to 29%) for elderly AML patients during the observation period. | 29223104 |
| Amyloidosis | Stem Cell Exhaustion | Adverse Prognostic Factors for Morbidity and Mortality During Peripheral Blood Stem Cell Mobilization in Patients with Light Chain Amyloidosis. | 29223373 |
| Hematopoietic stem cells, Amyloidosis | Stem Cell Exhaustion | Patients with immunoglobulin light chain (AL) amyloidosis undergoing peripheral blood hematopoietic stem cell (PBSC) mobilization for autologous hematopoietic stem cell transplantation (auto-HCT) can experience significant morbidity and mortality. | 29223373 |
| Rhabdoid Tumor | Stem Cell Exhaustion | We report a 7-week-old female with metastatic AT/RT and synchronous malignant rhabdoid tumor of the kidney who received an intensive multimodal approach combining surgical resection, intrathecal chemotherapy, and high-dose chemotherapy with autologous peripheral blood stem cell transplant (PBSCT). | 29223518 |
| Tachypnea | Stem Cell Exhaustion | In a multivariate analysis, history of autologous stem cell transplantation (HR, 31.151; 95% CI, 5.447-178.145; P < 0.001) and tachypnea at ED (HR, 4.392; 95% CI, 1.402-13.761; P = 0.011) were significantly associated with MERS-CoV infection. | 29223614 |
| Pancreatic carcinoma | Stem Cell Exhaustion | Doublecortin-like kinase 1 (DCLK1) is emerging as a tumor-specific stem cell marker in pancreatic cancer (PC). | 29224010 |
| Histiocytic Disorders, Malignant, Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cell and its niche in malignant progression of oral potentially malignant disorders. | 29224811 |
| Histiocytic Disorders, Malignant, Specialty Type - cancer | Stem Cell Exhaustion | The purpose of this study was to determine association between cancer stem cells (CSCs) and their niche with progression of oral potentially malignant disorders. | 29224811 |
| Lymphohistiocytosis, Hemophagocytic | Stem Cell Exhaustion | A 16-year-old boy with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (HLH) underwent allogeneic hematopoietic stem cell transplantation after conditioning with fludarabine, melphalan, total body irradiation, and rabbit antithymocyte globulin (ATG). | 29225252 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Adipose-derived mesenchymal stem cells (ASC) are attractive candidates in the search of novel strategies for OA treatment and exert anti-inflammatory and cytoprotective effects on cartilage. | 29230269 |
| Multiple Myeloma | Stem Cell Exhaustion | The combination of bortezomib, melphalan, and prednisone is a standard treatment for patients with newly diagnosed multiple myeloma who are ineligible for autologous stem-cell transplantation. | 29231133 |
| Multiple Myeloma | Stem Cell Exhaustion | In this phase 3 trial, we randomly assigned 706 patients with newly diagnosed multiple myeloma who were ineligible for stem-cell transplantation to receive nine cycles of bortezomib, melphalan, and prednisone either alone (control group) or with daratumumab (daratumumab group) until disease progression. | 29231133 |
| Cessation of life, Multiple Myeloma | Stem Cell Exhaustion | Among patients with newly diagnosed multiple myeloma who were ineligible for stem-cell transplantation, daratumumab combined with bortezomib, melphalan, and prednisone resulted in a lower risk of disease progression or death than the same regimen without daratumumab. | 29231133 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Consequently, OA has been associated with defects in the chondrocitic differentiation of progenitor stem cells (PSCs). | 29236045 |
| Degenerative polyarthritis | Stem Cell Exhaustion | To evaluate the effects of the non-amino bisphosphonate clodronate in OA patients we investigated SOX9 gene expression in circulating progenitor cells (CPCs) and in an in vitro OA model. | 29236045 |
| Aplastic Anemia | Stem Cell Exhaustion | Prognosis of hepatitis-associated aplastic anaemia (HAAA) was improved with haematopoietic stem cell transplantation (HSCT) and immunosuppression, but the long-term outcome remains undefined. | 29237659 |
| Cerebrovascular accident | Stem Cell Exhaustion | Endothelial progenitor cells enhance blood-brain barrier permeability in subacute stroke. | 29237797 |
| Ischemic stroke | Stem Cell Exhaustion | To study the association among endothelial progenitor cells (EPCs), subacute blood-brain barrier (BBB) permeability, and clinical outcome after ischemic stroke, determining the micro RNAs of EPCs responsible for good clinical outcome. | 29237797 |
| Lymphoma, Non-Hodgkin | Stem Cell Exhaustion | Adults (ages 18-75 years) with non-Hodgkin's lymphoma in first or second complete or partial remission, without previous hematopoietic stem cell mobilization or autologous transplant, were included. | 29238988 |
| Lymphoma, Non-Hodgkin | Stem Cell Exhaustion | Plerixafor and granulocyte-colony-stimulating factor for mobilization of hematopoietic stem cells for autologous transplantation in Chinese patients with non-Hodgkin's lymphoma: a randomized Phase 3 study. | 29238988 |
| Lymphoma, Non-Hodgkin | Stem Cell Exhaustion | This Phase 3 randomized, double-blind study evaluated the efficacy and safety of plerixafor plus granulocyte-colony-stimulating factor for the mobilization of hematopoietic stem cells in Chinese patients with non-Hodgkin's lymphoma. | 29238988 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | A substantial proportion of patients with acute graft-versus-host disease (aGVHD) respond to cell therapy with culture-expanded human bone marrow mesenchymal stromal/stem cells (BM-MSCs). | 29239062 |
| Neutropenia, Hematologic Neoplasms | Stem Cell Exhaustion | A total of 152 febrile neutropenia (FEN) patients with hematological malignancies aged over 18 years and receiving high-dose chemotherapy or stem cell transplant between January 1, 2010, and December 31, 2012 were included in the study. | 29239468 |
| Degenerative polyarthritis | Stem Cell Exhaustion | Progenitor cells from different zones of human cartilage and their correlation with histopathological osteoarthritis progression. | 29240251 |
| Degenerative polyarthritis | Stem Cell Exhaustion | This study focused on quantitative assessment of the concentration and biological potential of stem and progenitor cells resident in different zones of cartilage displaying macroscopic Outerbridge grade 1-2 OA, and their correlation with OA progression based on established histologic scoring system. | 29240251 |
| leukemia, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Allogeneic stem cell transplantation benefits for patients >= 60 years with acute myeloid leukemia and FLT3 internal tandem duplication: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. | 29242299 |
| FLT3 Internal Tandem Duplication, Cytogenetically normal acute myeloid leukemia | Stem Cell Exhaustion | Intermediate-risk cytogenetic acute myeloid leukemia with an internal tandem duplication of FLT3 (FLT3-ITD) is associated with a high risk of relapse, and is now a standard indication for allogeneic stem cell transplantation. | 29242299 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Prospective randomization of post-remission therapy comparing autologous peripheral blood stem cell transplantation versus high-dose cytarabine consolidation for acute myelogenous leukemia in first remission. | 29243031 |
| International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) Criteria - Favorable-Risk Group, Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | We prospectively compared outcomes of autologous stem cell transplantation (ASCT) versus high-dose cytarabine (HiDAC) consolidation as post-remission therapy for favorable- and intermediate-risk acute myelogenous leukemia (AML) in first complete remission (CR1). | 29243031 |
| Specialty Type - cancer, Refractory Cytopenia of Childhood | Stem Cell Exhaustion | Thus, the present study was conducted to evaluate the expression and prognostic significance of CD44 as a cancer stem cell marker in different histological subtypes of RCC. | 29243496 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cell marker CD44 may be a promising target for cancer treatment only in ccRCC. | 29243496 |
| Atrial Fibrillation by ECG Finding | Stem Cell Exhaustion | Preferential myofibroblast differentiation of cardiac mesenchymal progenitor cells in the presence of atrial fibrillation. | 29245016 |
| Myeloid Leukemia, Chronic | Stem Cell Exhaustion | Copper-associated hepatitis in a patient with chronic myeloid leukemia following hematopoietic stem cell transplantation: A case report. | 29245301 |
| Alport Syndrome, Autosomal Recessive | Stem Cell Exhaustion | Integration-free induced pluripotent stem cells derived from a patient with autosomal recessive Alport syndrome (ARAS). | 29246570 |
| Alzheimers Disease | Stem Cell Exhaustion | Generation and characterization of human induced pluripotent stem cell (hiPSC) lines from an Alzheimer's disease (ASUi003-A) and non-demented control (ASUi004-A) patient homozygous for the Apolipoprotein e4 (APOE4) risk variant. | 29246571 |
| Up, Nested Diagnostic Context | Stem Cell Exhaustion | Here, we generated human induced pluripotent stem cell (hiPSC) lines from the peripheral blood mononuclear cells (PBMCs) of a clinically diagnosed AD patient [ASUi003-A] and a non-demented control (NDC) patient [ASUi004-A] homozygous for the APOE4 risk allele. | 29246571 |
| Carcinoma of larynx | Stem Cell Exhaustion | Development of one control and one tumor-specific induced pluripotent stem cell line from laryngeal carcinoma patient. | 29246575 |
| Neoplasms | Stem Cell Exhaustion | Control and tumor specific induced pluripotent stem cells were reprogrammed with 5 reprogramming factors, Klf-4, c-Myc, Oct-4, Sox-2, and Lin-28, using the messenger RNA reprogramming system. | 29246575 |
| Multiple Myeloma | Stem Cell Exhaustion | Vinorelbine combined with filgrastim at a dose of 10 ug/kg of body weight (BW) per day is a reliable and well-tolerated regimen for mobilization of hematopoietic progenitor cells (HPCs) in patients with multiple myeloma. | 29246820 |
| Vascular smooth muscle cell, Vascular System Injuries | Stem Cell Exhaustion | MicroRNA-22 (miR-22) has recently been reported to play a regulatory role during vascular smooth muscle cell (VSMC) differentiation from stem cells, but little is known about its target genes and related pathways in mature VSMC phenotypic modulation or its clinical implication in neointima formation following vascular injury. | 29246895 |
| Malignant Neoplasms | Stem Cell Exhaustion | Ipilimumab plus Lenalidomide after Allogeneic and Autologous Stem Cell Transplantation for Patients with Lymphoid Malignancies. | 29246938 |
| Malignant Neoplasms | Stem Cell Exhaustion | Purpose: Prevention or treatment of relapsed lymphoid malignancies after hematopoietic stem cell transplantation (HSCT) requires novel strategies. | 29246938 |
| leukemia | Stem Cell Exhaustion | Allogeneic Stem Cell Transplantation versus Tyrosine Kinase Inhibitors Combined with Chemotherapy in Patients with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia. | 29247779 |
| B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1, BCR gene | Stem Cell Exhaustion | Here we compare outcomes between the tyrosine kinase inhibitors (TKIs) plus chemotherapy regimen and allogeneic hematopoietic stem cell transplantation (transplantation cohort) in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) and explore factors associated with prognosis. | 29247779 |
| BCR gene | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation confers significant survival advantages for Ph+ ALL patients compared with TKIs plus chemotherapy, especially in intermediate- and high-risk patients. | 29247779 |
| leukemia | Stem Cell Exhaustion | Intravenous Busulfan Compared with Treosulfan-Based Conditioning for Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia: A Study on Behalf of the Acute Leukemia Working Party of European Society for Blood and Marrow Transplantation. | 29247780 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Dose intensity of the conditioning regimen has significant impact on the outcomes after stem cell transplantation (SCT) for acute myeloid leukemia. | 29247780 |
| Hematological Disease | Stem Cell Exhaustion | We evaluated the impact of unidirectional donor versus recipient killer cell immunoglobulin-like receptor (KIR)-ligand mismatch (KIR-Lmm) on the outcomes of T cell-replete haploidentical stem cell transplantation (Haplo-SCT) with post-transplant cyclophosphamide (PT-Cy) in a cohort of 144 patients treated for various hematologi diseases. | 29247781 |
| Hematologic Neoplasms, Hematopoiesis | Stem Cell Exhaustion | Imaging of subclinical haemopoiesis after stem-cell transplantation in patients with haematological malignancies: a prospective pilot study. | 29248669 |
| leukemia | Stem Cell Exhaustion | National Institutes of Health, Ben's Run/Ben's Gift, Albert and Elizabeth Tucker Foundation, Mex Frates Leukemia Fund, Jones Family fund, and Oklahoma Center for Adult Stem Cell Research. | 29248669 |
| Childhood Breast Carcinoma, Resistance Process | Stem Cell Exhaustion | JAK/STAT3-Regulated Fatty Acid b-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance. | 29249690 |
| Specialty Type - cancer | Stem Cell Exhaustion | Cancer stem cells (CSCs) are critical for cancer progression and chemoresistance. | 29249690 |
| Nephrotic Syndrome | Stem Cell Exhaustion | Nephrotic syndrome after autologous hematopoietic stem cell transplantation: a case report. | 29250696 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Expression of multiple leukemic stem cell markers is associated with poor prognosis in de novo acute myeloid leukemia. | 29251166 |
| Leukemia, Myelocytic, Acute | Stem Cell Exhaustion | Leukemic stem cells (LSCs) play a crucial role in chemotherapy resistance in acute myeloid leukemia (AML). | 29251166 |
| Liver carcinoma, Hollings Cancer Center, Malignant neoplasm of liver | Stem Cell Exhaustion | Cluster of differentiation (CD)90 (Thy-1) was proposed as a marker for the liver cancer stem cells that are responsible for tumorigenic activity, however its involvement in the progression of hepatocellular carcinoma (HCC) remains unknown. | 29251325 |
| Lymphoma | Stem Cell Exhaustion | Bone Marrow Versus Peripheral Blood Stem Cell Transplant in Lymphoma: A Systematic Review and Meta-Analysis. | 29251579 |
| Lymphoma | Stem Cell Exhaustion | Studies that compared bone marrow transplant versus peripheral blood stem cell transplant in lymphoma patients were searched. | 29251579 |
| Hematologic Neoplasms | Stem Cell Exhaustion | High-dose chemotherapy alongside peripheral blood stem cell (PBSC) infusion has become the standard of care in different hematologic malignancies. | 29255168 |
| Chronic Lymphocytic Leukemia, Malignant Neoplasms | Stem Cell Exhaustion | Outcomes of haploidentical stem cell transplantation for chronic lymphocytic leukemia: a retrospective study on behalf of the chronic malignancies working party of the EBMT. | 29255169 |
| Chronic Lymphocytic Leukemia | Stem Cell Exhaustion | Allogeneic hematopoietic stem cell transplantation (HCT) may result in long-term disease control in high-risk chronic lymphocytic leukemia (CLL). | 29255169 |
| Muscular Dystrophy, Duchenne | Stem Cell Exhaustion | This enrichment and maturation strategy restored dystrophin in hundreds of dystrophin-deficient myofibres after engraftment of CRISPR-Cas9-corrected Duchenne muscular dystrophy human induced pluripotent stem cell-SMPCs. | 29255171 |
| Systemic Scleroderma | Stem Cell Exhaustion | Safety profile of autologous hematopoietic stem cell mobilization and transplantation in patients with systemic sclerosis. | 29256111 |
| Toxic effect | Stem Cell Exhaustion | Autologous hematopoietic stem cell transplantation (AHSCT) is thought to be effective therapeutic approach in patients with poor prognosis systemic sclerosis; however, the toxicity remains a challenge. | 29256111 |
| Diabetes Mellitus, Insulin-Dependent | Stem Cell Exhaustion | We were the first to demonstrate that stem cells obtained from the pulp of natal teeth could be differentiated into insulinproducing cells, which might prove useful in the stem cell therapy for type 1 diabetes. | 29256855 |
| Diabetes Mellitus | Stem Cell Exhaustion | Mesenchymal stem cells have the ability to differentiate into insulin-producing cells, raising the hope for diabetes mellitus treatment. | 29256855 |
| Palmar-plantar erythrodysesthesia syndrome | Stem Cell Exhaustion | Here we investigated whether chemotherapy-induced senescence could change stem-cell-related properties of malignant cells. | 29258294 |
| Lymphoma | Stem Cell Exhaustion | Gene expression and functional analyses comparing senescent and non-senescent B-cell lymphomas from Em-Myc transgenic mice revealed substantial upregulation of an adult tissue stem-cell signature, activated Wnt signalling, and distinct stem-cell markers in senescence. | 29258294 |
| Leukemia, Myelocytic, Acute, Acute lymphocytic leukemia | Stem Cell Exhaustion | Notably, the temporary enforcement of senescence in p53-regulatable models of acute lymphoblastic leukaemia and acute myeloid leukaemia was found to reprogram non-stem bulk leukaemia cells into self-renewing, leukaemia-initiating stem cells. | 29258294 |
| Multiple Myeloma, BDI - Functional Impairment | Stem Cell Exhaustion | Utility of a patient-reported outcome in measuring functional impairment during autologous stem cell transplant in patients with multiple myeloma. | 29260444 |
| Multiple Myeloma | Stem Cell Exhaustion | We aimed to determine the utility of a patient-reported outcome (PRO) as it relates to patient performed testing (PPT) for measuring functional status in multiple myeloma patients after autologous hematopoietic stem cell transplantation (auto-HCT). | 29260444 |
| Childhood Breast Carcinoma | Stem Cell Exhaustion | Our results suggest that 2-14 mutations in the genome of breast stem cells are required for normal breast stem cells to become a malignant cell, and 3 gene mutations are most likely to occur in the development of female breast cancer. | 29265879 |
| Specialty Type - cancer, Extraocular Cutaneous Sebaceous Carcinoma, Squamous cell carcinoma | Stem Cell Exhaustion | We herein describe the first case of extraocular sebaceous carcinoma accompanied by invasive squamous cell carcinoma, which might have arisen from biphasic differentiation of cancer stem cells. | 29266386 |
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Allogeneic stem cell transplantation (ASCT) represents the only option with a potential cure rate of 30% to 50% in myelodysplastic syndrome (MDS); however, < 5% of patients are optimal candidates for this management. | 29268959 |
| Reticulosarcoma, Pneumonia | Stem Cell Exhaustion | A 60-year-old man developed pneumonia after undergoing autologous peripheral blood stem cell transplantation for diffuse large-B cell lymphoma. | 29269681 |
| Amyloidosis | Stem Cell Exhaustion | Impact of prior melphalan exposure on stem cell collection in light chain amyloidosis. | 29269795 |
| Multiple Myeloma | Stem Cell Exhaustion | Use of melphalan in multiple myeloma was observed to have a deleterious effect on stem cell collection in older studies. | 29269795 |
| Amyloidosis | Stem Cell Exhaustion | We retrospectively evaluated stem cell mobilization in 610 patients with AL amyloidosis, of which 79 had prior exposure to melphalan, 167 to other chemotherapeutics, while 364 had no chemotherapy exposure. | 29269795 |
| Pneumocystis jiroveci pneumonia | Stem Cell Exhaustion | A prospective study of intravenous pentamidine for PJP prophylaxis in adult patients undergoing intensive chemotherapy or hematopoietic stem cell transplant. | 29269796 |
| Pneumocystis jiroveci pneumonia | Stem Cell Exhaustion | Prophylaxis for Pneumocystis jirovecii pneumonia (PJP) is recommended for patients undergoing hematopoietic stem cell transplantation (HSCT) or intensive chemotherapy. | 29269796 |
| Fatigue | Stem Cell Exhaustion | Deconditioning, fatigue and impaired quality of life in long-term survivors after allogeneic hematopoietic stem cell transplantation. | 29269801 |
| Fatigue | Stem Cell Exhaustion | Long-term survivors after allogeneic hematopoietic stem cell transplantation (allo-HSCT) are at high risk for treatment-related adverse events, that may worsen physical capacity and may induce fatigue and disability. | 29269801 |
| Experimental Organism Malignant Hepatocholangiocellular Carcinoma | Stem Cell Exhaustion | Look into hepatic progenitor cell associated trait: Histological heterogeneity of hepatitis B-related combined hepatocellular-cholangiocarcinoma. | 29270746 |
| Fibrous Dysplasia, Hodgkin Disease, Retinoblastoma | Stem Cell Exhaustion | Three patients had previous irradiation (2 for retinoblastoma, 1 for fibrous dysplasia) and 1 patient had chemotherapy and stem cell transplantation for Hodgkin lymphoma. | 29270859 |
| Degenerative disorder | Stem Cell Exhaustion | Stem cell transplantation has been considered a promising therapy for retinal degenerative diseases. | 29273085 |
| Retinal Degeneration | Stem Cell Exhaustion | Adult human periodontal ligament-derived stem cells delay retinal degeneration and maintain retinal function in RCS rats. | 29273085 |
| BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 20 | Stem Cell Exhaustion | Our findings suggest that programmed differences in infant stem cell metabolism correspond with differences in body composition in early life, a known contributor to obesity risk. | 29273781 |
| adiposity | Stem Cell Exhaustion | Altered gene expression and metabolism in fetal umbilical cord mesenchymal stem cells correspond with differences in 5-month-old infant adiposity gain. | 29273781 |
| Specialty Type - cancer | Stem Cell Exhaustion | Studying laboratory cell lines as well as clinical specimens indicate that PTC may follow the cancer stem cell (CSC) model. | 29274322 |
| Papillary thyroid carcinoma, Specialty Type - cancer | Stem Cell Exhaustion | Subpopulations of cancer stem cells found in papillary thyroid carcinoma. | 29274322 |
| Myotonic Dystrophy, IGHD1-7 gene | Stem Cell Exhaustion | Human immortalized Epstein-Barr virus (EBV) lymphoblastoids cells line (LCLs) from a 26-year- old male affected by an adult form of myotonic dystrophy type 1 (DM1) disease and carrying 200 CTG repeats mutation in the blood was used to generate induced pluripotent stem cells (iPSCs) using the Sendai virus expressing KLF4, OCT4, SOX2 and C-MYC. | 29274549 |
| Ki-1+ Anaplastic Large Cell Lymphoma, Hodgkin Disease | Stem Cell Exhaustion | Brentuximab vedotin is currently approved for patients with relapsed or refractory Hodgkin's lymphoma who previously received an autologous stem cell transplant or two previous multiagent chemotherapy regimens, and for patients with relapsed or refractory systemic anaplastic large-T-cell lymphoma who previously received at least one chemotherapy regimen. | 29276022 |
| Lymphoma | Stem Cell Exhaustion | Management of Advanced and Relapsed/Refractory Extranodal Natural Killer T-Cell Lymphoma: An Analysis of Stem Cell Transplantation and Chemotherapy Outcomes. | 29277360 |
| Small cell carcinoma of lung, Neoplasms | Stem Cell Exhaustion | Preclinical studies in small cell lung cancer (SCLC) have shown that hyaluronic acid (HA) can be effectively used to deliver chemotherapy and selectively decrease CD44 expressing (stem cell-like) tumour cells. | 29277856 |
| Gastrointestinal mucositis | Stem Cell Exhaustion | Impact of Oral and Gastrointestinal Mucositis on Body Weight Alterations during Hematopoietic Stem Cell Transplantation. | 29278934 |
| Gastrointestinal tract structure | Stem Cell Exhaustion | The aim of this study was to evaluate whether digestive tract mucositis is a predictive factor for body weight (BW) alterations during hematopoietic stem cell transplantation (HSCT). | 29278934 |
| Infections, Hospital, Forecast of outcome | Stem Cell Exhaustion | Human Parainfluenza Virus Type 3 Infections in Patients with Hematopoietic Stem Cell Transplants: the Mode of Nosocomial Infections and Prognosis. | 29279454 |
| Virus Diseases | Stem Cell Exhaustion | There have been a few prospective and comprehensive surveillance studies on the respiratory viral infections (RVIs) among patients undergoing hematopoietic stem cell transplantation (HSCT). | 29279454 |
| Antiphospholipid Syndrome, Chronic graft-versus-host disease | Stem Cell Exhaustion | The patient had previously undergone allogeneic hematopoietic stem cell transplantation and had been diagnosed with antiphospholipid syndrome (APS) during the development of chronic graft-versus-host disease. | 29279512 |
| Multiple Myeloma | Stem Cell Exhaustion | Analysis of long-term survival in multiple myeloma after first-line autologous stem cell transplantation: impact of clinical risk factors and sustained response. | 29282899 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | The widespread use of high-dose therapy and autologous stem cell transplantation (ASCT) as well as the introduction of novel agents have significantly improved outcomes in multiple myeloma (MM) enabling long-term survival. | 29282899 |
| Malignant Neoplasms | Stem Cell Exhaustion | Patients had to have continuous membership with drug benefit eligibility and no prior history of stem cell transplant (SCT) or other cancers during the 12 months prior to the index date. | 29284347 |
| Cessation of life | Stem Cell Exhaustion | All patients were followed from index TKI therapy until end of study time period (12 December 2014), death, stem cell transplant, or disenrollment from the health plan unless one of the following occurred first: a patient switched their index therapy, or a patient discontinued their index therapy. | 29284347 |
| Toxic effect, Multiple Myeloma | Stem Cell Exhaustion | Comparison of conditioning regimen toxicities among autologous stem cell transplantation eligible multiple myeloma patients: High-dose melphalan versus high-dose melphalan and bortezomib. | 29284356 |
| Morular Metaplasia of the Endometrium, Multiple Myeloma | Stem Cell Exhaustion | Background Autologous hematopoietic stem cell transplantation (AHSCT) remains the standard of care for younger patients with multiple myeloma (MM). | 29284356 |
| Thromboembolic stroke | Stem Cell Exhaustion | Human Neural Stem Cell Extracellular Vesicles Improve Tissue and Functional Recovery in the Murine Thromboembolic Stroke Model. | 29285679 |
| Infarction | Stem Cell Exhaustion | Neural stem cell (NSC) and mesenchymal stem cell (MSC) EVs derived from the same pluripotent stem cell (PSC) line were evaluated for changes in infarct volume as well as sensorimotor function. | 29285679 |
"
| PAFAH1B1 wt Allele, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Utility of 5-Methylcytosine Immunohistochemical Staining to Assess Global DNA Methylation and Its Prognostic Impact in MDS Patients Background: DNA methylation plays a vital role in the pathogenesis of the myelodysplastic syndrome (MDS),
a heterogeneous group of clonal hematopoietic stem cell (HSC) disorders. | 29286224 | "
| Cardiovascular Diseases | Stem Cell Exhaustion | It is a great resource for discovery of novel predictive factors for cardiovascular disease outcomes, including genomics, transcriptomics, protein biomarkers, oxidative stress markers and circulating progenitor cells. | 29288185 |
| leukemia, Adult Myelodysplastic Syndrome | Stem Cell Exhaustion | Reduced-Intensity Allogeneic Transplant for Acute Myeloid Leukemia and Myelodysplastic Syndrome Using Combined CD34-Selected Haploidentical Graft and a Single Umbilical Cord Unit Compared with Matched Unrelated Donor Stem Cells in Older Adults. | 29288821 |
| Myoclonic Epilepsy, MERRF Syndrome | Stem Cell Exhaustion | Generation of an induced pluripotent stem cell (iPSC) line from a 40-year-old patient with the A8344G mutation of mitochondrial DNA and MERRF (myoclonic epilepsy with ragged red fibers) syndrome. | 29288969 |
| Hodgkin Disease, LIPC gene | Stem Cell Exhaustion | Based on promising pilot data a phase II tandem autologous hematopoietic stem cell transplant (AHSCT) trial for relapsed/refractory Hodgkin lymphoma (HL) was performed in the US intergroup setting to determine if long-term progression-free survival (PFS) could be improved. | 29289757 |
| Hypertensive (finding), Hypertension, CTCAE | Stem Cell Exhaustion | Objective The aim of this study was to investigate the relationship between peripheral plasma stem cell factor (SCF)/c-kit levels and the types of dipper and non-dipper hypertension in hypertensive patients. | 29301598 |
| Alzheimers Disease | Stem Cell Exhaustion | Establishment of induced pluripotent stem cell line (ZZUi009-A) from an Alzheimer's disease patient carrying a PSEN1 gene mutation. | 29304399 |
| Fibroid Tumor, Hypoxia | Stem Cell Exhaustion | These hypotheses include the loss of telocytes' functions as "sex hormone sensors" and regulators of smooth muscle cells cycle; the role of telocytes as progenitor cells for the development of leiomyomas; and the hypothesis of decreased angiogenesis after telocytes' loss with subsequent hypoxia (as a key factor for leiomyomas development). | 29317071 |
| Scleroderma | Stem Cell Exhaustion | However, subcutaneous injections of autologous adipose tissue-derived stromal vascular fraction (ADSVF), which is known to contain mesenchymal stem cells, in hands of Patients with scleroderma for enhancing their impaired hand function is still in an experimental stage, although there are already promising results of the therapy. | 29324934 |
| Prostate carcinoma | Stem Cell Exhaustion | This study explored the association between a single-nucleotide polymorphism of prostate stem cell antigen and prostate cancer in Chinese patients undergoing prostate biopsy. | 29332451 |
| Prostate carcinoma | Stem Cell Exhaustion | Men with the rs1045531 AC genotype of prostate stem cell antigen were at higher risk of prostate cancer in Chinese patients undergoing prostate biopsy. | 29332451 |
| Impaired cognition | Stem Cell Exhaustion | Hippocampal avoidance during whole-brain radiotherapy is performed to prevent neural stem cell injury causing neurocognitive dysfunction. | 29332467 |
| Neoplastic Post-Transplant Lymphoproliferative Disorder, Thalassemia | Stem Cell Exhaustion | Diagnosis and treatment of neoplastic post-transplant lymphoproliferative disorder following hematopoietic stem cell transplant in b-thalassemia: A pediatric case report. | 29384898 |
| Post-transplant lymphoproliferative disorder | Stem Cell Exhaustion | In this report we reviewed the case of a pediatric patient who experienced PTLD after allogeneic hematopoietic stem cell transplantation (HSCT) from a human leukocyte antigen (HLA)-identical sibling. | 29384898 |
| Post-transplant lymphoproliferative disorder | Stem Cell Exhaustion | The status of stem cell implantation after transplantation, and graft versus host disease should be evaluated jointly, and rituximab therapy and chemotherapy with BFM-95 may be used for treatment of pediatric PTLD after HSCT. | 29384898 |
| Acute lymphocytic leukemia | Stem Cell Exhaustion | Efficacy and safety of autologous peripheral blood stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia: A study protocol for a multicenter exploratory prospective study (Auto-Ph17 study). | 29384978 |
| Multiple Myeloma | Stem Cell Exhaustion | Recombinant human thrombopoietin improves the efficacy of intermediate-dose cyclophosphamide plus granulocyte colony-stimulating factor in mobilizing peripheral blood stem cells in patients with multiple myeloma: A cohort study. | 29390394 |
| Multiple Myeloma | Stem Cell Exhaustion | The combination of intermediate-dose cyclophosphamide (ID-CTX) and granulocyte colony-stimulating factor (G-CSF) fails to mobilize peripheral blood stem cells (PBSCs) in approximately 20% of treated patients with multiple myeloma (MM).In this cohort study, patients with MM underwent PBSC mobilization with either an ID-CTX plus G-CSF plus recombinant human thrombopoietin (rhTPO) regimen (72 patients; TPO group), or an ID-CTX plus G-CSF regimen (70 patients; non-TPO group).In the TPO group, the median CD34+ harvest was 5.36 x 10 per kg of body weight (0.50-22.39 x 10 per kg of body weight), with a harvest success rate of 91.7% (66/72), and an excellence rate of 55.6% (40/72). | 29390394 |
| Cutaneous | Stem Cell Exhaustion | The patient attained partial remission after undergoing 2 rounds of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP regimen) before autologous stem cell transplantation, however, he quickly relapsed and developed new cutaneous lesions. | 29390581 |
| Unmedicated Sponge Dosage Form, Dementia | Stem Cell Exhaustion | Late-stage progenitor cells were quantified in the subgranular zone (SGZ) of the hippocampal dentate gyrus of DLB/PDD patients (n = 41) and controls without dementia (n = 15) and compared between treatment groups (unmedicated, SSRIs, acetyl cholinesterase inhibitors [AChEIs], combined SSRIs and AChEIs). | 29393203 |
| Cerebrovascular accident | Stem Cell Exhaustion | Endothelial Progenitor Cells influence acute and subacute stroke hemodynamics. | 29406889 |
| MYELODYSPLASTIC SYNDROME | Stem Cell Exhaustion | To investigate the frequencies and biological characteristics of CD25 positive hematopoietic stem cells (HSC) in myelodysplastic syndromes. | 29407181 |
| Stevens-Johnson Syndrome, Keratitis, Facial paralysis, Keratoconus, Special Handling Code - Dry | Stem Cell Exhaustion | Indications for fitting included limbal stem cell deficiency, post-photorefractive keratectomy (PRK) decentred ablation, pellucid marginal degeneration, Stevens-Johnson syndrome, keratoconus, dry eye, neurotrophic keratitis, exposure keratitis from facial nerve paralysis, and post-radial keratotomy (RK) symptoms. | 29426444 |
| Sarcoma, Specialty Type - cancer | Stem Cell Exhaustion | Alterations in cancer stem-cell marker CD44 expression predict oncologic outcome in soft-tissue sarcomas. | 29433875 |
| Specialty Type - cancer, Secondary Neoplasm | Stem Cell Exhaustion | Cancer stem cells (CSCs) have been shown to resist chemotherapy and promote metastasis after cytotoxic therapies. | 29433875 |
| Adult Glioblastoma | Stem Cell Exhaustion | Upstream stimulating factor1 (USF1) enhances the proliferation of glioblastoma stem cells mainly by activating the transcription of mucin13 (MUC13). | 29441861 |
| Adult Glioblastoma | Stem Cell Exhaustion | Firstly, the expression of MUC13 was explored in glioblastoma stem cells (GSCs) and we found that MUC13 was significantly enhanced in GSCs. | 29441861 |
| Cutaneous Precancerous Condition, Malignant neoplasm of stomach, Specialty Type - cancer | Stem Cell Exhaustion | Expression of Cancer Stem Cell Marker CD44 and Its Polymorphisms in Patients with Chronic Gastritis, Precancerous Gastric Lesion, and Gastric Cancer: A Cross-Sectional Multicenter Study in Thailand. | 29445738 |
| Graft-vs-Host Disease, Acute GVH disease | Stem Cell Exhaustion | Acute graft-versus-host disease (GvHD) is a process that classically has been defined as occurring less than 100 days after stem cell transplant. | 29469783 |
| Septic Shock | Stem Cell Exhaustion | A 50-year-old man with diffuse large B-cell lymphoma who had undergone an allogeneic stem cell transplant 20 months previously was admitted for neutropenic septic shock. | 29469783 |
| Acute GVH disease | Stem Cell Exhaustion | This case provides particular insight into the diagnosis and management of late-presenting acute GvHD given that it is the first reported case of Stage IV cutaneous acute GvHD more than 12 months after stem cell transplant. | 29469783 |
| Acute GVH disease | Stem Cell Exhaustion | In the setting of decreased immunosuppression in a patient with a history of a stem cell transplant, acute graft-versus-host disease must be considered regardless of the time that has elapsed since transplant. | 29469783 |
| Specialty Type - cancer | Stem Cell Exhaustion | Nestin is considered to be a cancer stem cell marker. | 29517198 |
| Motor retardation | Stem Cell Exhaustion | Allogeneic fetal stem cell transplantation to child with psychomotor retardation - A case report. | 29652457 |
"
| malignant disease, leukemia | Stem Cell Exhaustion | The consequences of autologous and allogeneic stem cell transplantation (stem cells of
hematopoiesis), applied in adults and children suffering from leukemia or some other malignant disease,
are well-known and sufficiently recognizable in pediatric clinical practice regardless of the indication
for the treatment. | 29652457 | "
"
| Motor retardation, Epilepsy | Stem Cell Exhaustion | However, the efficacy of fetal stem cell transplantation is unrecognizable when the
indications are psychomotor retardation and epilepsy. | 29652457 | "
"
| Motor retardation, Epilepsy | Stem Cell Exhaustion | The main aim of allogeneic fetal
stem cell transplantation was treatment of psychomotor retardation and epilepsy. | 29652457 | "
"
| Psychiatric service | Stem Cell Exhaustion | With the exception of neurological psychiatric problems, a boy aged 9.5 years was in good
general health before transplantation with allogeneic fetal stem cells. | 29652457 | "
| PAFAH1B1 wt Allele | Stem Cell Exhaustion | The only curative treatment for MDS is allogeneic stem cell transplantation (SCT). | 29668469 |
"
| Coronary Arteriosclerosis | Stem Cell Exhaustion | The aim of the study was to
evaluate long-term outcome of patients
with diffuse coronary artery disease,
treated with autologous stem cells injections
combined with transmyocardial
laser revascularization. | 29694766 | "
| Hypertensive (finding) | Stem Cell Exhaustion | EFFICACY OF MESENCHYMAL STEM CELLS USED FOR THE IMPROVEMENT CEREBRAL MICROCIRCULATION IN SPONTANEOUSLY HYPERTENSIVE RATS. | 30188091 |
| Hypertensive (finding) | Stem Cell Exhaustion | We studied influence of intracerebral transplantation of human mesenchymal stem cells (MSCh) to cerebral microcirculation in young (4 months) and aged (12 months) spontaneously hypertensive rats (SHR). | 30188091 |